metaid_0000015
constant: true
units: 120190
value: 10600.0
name: AE50
type: Parameter

metaid_0000009
constant: true
units: 120099
value: 0.44359
name: Dose_Length
type: Parameter

120086
exponent: 1.0
scale: 0
multipler: 1.0
kind: DIMENSIONLESS
type: SBMLUnit

metaid_503042
constant: false
units: dimensionless
value: NaN
name: Effect
type: Parameter

metaid_0000019
constant: true
units: 120164
value: 6.66
name: Size_0
type: Parameter

120281
unit: 120307
unit: 120294
name: per_cm_per_week
type: SBMLUnitsDef

120242
exponent: 1.0
scale: 0
multipler: 604800.0
kind: SECOND
type: SBMLUnit

metaid_0000012
constant: true
units: 120125
value: 604800.0
name: conversion_factor
type: Parameter

BIOMD0000000234
units def: 120281
parameter: metaid_503042
rule: metaid_0000025
units def: 120190
parameter: metaid_0000008
is described by: http://identifiers.org/pubmed/18594002
parameter: metaid_0000011
units def: 120216
rule: metaid_0000028
rule: metaid_0000030
rule: metaid_0000024
created:
  W3 CDTF: Mon Nov 16 12:37:34 GMT 2009
rule: metaid_0000029
area units: metaid_0000005
notes: This a model from the article: Pharmacodynamic Model for the Time Course of Tumor Shrinkage by Gemcitabine + Carboplatin in Non–Small Cell Lung Cancer Patients Lai-San Tham1, Lingzhi Wang1, Ross A. Soo1, Soo-Chin Lee1, How-Sung Lee2, Wei-Peng Yong1, Boon-Cher Goh1 and Nicholas H.G. Holford3 Clinical Cancer Research July 1, 2008 14, 4213 18594002 , Abstract: PURPOSE: This tumor response pharmacodynamic model aims to describe primary lesion shrinkage in non-small cell lung cancer over time and determine if concentration-based exposure metrics for gemcitabine or that of its metabolites, 2',2'-difluorodeoxyuridine or gemcitabine triphosphate, are better than gemcitabine dose for prediction of individual response. EXPERIMENTAL DESIGN: Gemcitabine was given thrice weekly on days 1 and 8 in combination with carboplatin, which was given only on day 1 of every cycle. Gemcitabine amount in the body and area under the concentration-time curves of plasma gemcitabine, 2',2'-difluorodeoxyuridine, and intracellular gemcitabine triphosphate in white cells were compared to determine which best describes tumor shrinkage over time. Tumor growth kinetics were described using a Gompertz-like model. RESULTS: The apparent half-life for the effect of gemcitabine was 7.67 weeks. The tumor turnover time constant was 21.8 week.cm. Baseline tumor size and gemcitabine amount in the body to attain 50% of tumor shrinkage were estimated to be 6.66 cm and 10,600 mg. There was no evidence of relapse during treatment. CONCLUSIONS: Concentration-based exposure metrics for gemcitabine and its metabolites were no better than gemcitabine amount in predicting tumor shrinkage in primary lung cancer lesions. Gemcitabine dose-based models did marginally better than treatment-based models that ignored doses of drug administered to patients. Modeling tumor shrinkage in primary lesions can be used to quantify individual sensitivity and response to antitumor effects of anticancer drugs. This model originates fro…
parameter: metaid_0000006
parameter: metaid_0000016
species: 503043
parameter: metaid_0000020
parameter: metaid_0000009
parameter: metaid_0000019
units def: 120073
length unit: length
is version of: http://identifiers.org/omim/211980
units def: 120125
parameter: metaid_503040
modified:
  W3 CDTF: Fri Mar 09 15:47:44 GMT 2012
units def: 120320
units def: 120099
parameter: metaid_0000012
is version of: C34
parameter: metaid_0000017
type: SBMLModel
compartment: metaid_0000023
rule: metaid_0000027
is: MODEL0911120001
creator:
  ORG:
    orgname: Auckland Bioengineering Institute, The Auckland University
  n:
    given: Geoffrey
    family: Nunns
name: Tham2008_PDmodel_TumourShrinkage
parameter: metaid_0000021
creator:
  ORG:
    orgname: EMBL-EBI
  n:
    given: Vijayalakshmi
    family: Chelliah
occurs in: http://identifiers.org/taxonomy/9606
volume units: metaid_0000004
curated: true
parameter: metaid_503041
parameter: metaid_0000004
parameter: metaid_0000010
rule: metaid_0000026
time units: metaid_0000003
parameter: metaid_0000007
units def: 120255
substance units: 094936
rule: metaid_0000031
units def: 120164
is version of: GO:0002357
parameter: metaid_0000022
parameter: metaid_0000015
creator:
  ORG:
    orgname: Department of Hematology-Oncology, National University Hospital.
  n:
    given: Lai-San
    family: Tham

metaid_0000020
constant: false
units: 120255
value: NaN
name: RateIn
type: Parameter

metaid_0000016
constant: false
units: 120255
value: NaN
name: Keq
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120307
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120203
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120190
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metaid_503041
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name: Size
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metaid_0000006
constant: true
units: 120190
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name: Dose
type: Parameter

metaid_0000011
constant: true
units: dimensionless
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metaid_0000023
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spatial dimensions: 3.0
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120112
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120255
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name: per_week
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120333
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120268
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metaid_0000007
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name: Dose_Int1
type: Parameter

503043
is: SBO:0000247
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boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: metaid_0000023
name: Ce
type: Species

metaid_0000017
constant: true
units: 120099
value: 7.67
name: Teq
type: Parameter

120164
unit: 120177
name: cm
type: SBMLUnitsDef

120099
unit: 120112
name: week
type: SBMLUnitsDef

metaid_503040
constant: false
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value: NaN
name: Exposure
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metaid_0000022
constant: false
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value: NaN
name: Kover
type: Parameter

metaid_0000010
constant: true
units: 120099
value: 3.0
name: Cycle_Int
type: Parameter

120125
unit: 120151
unit: 120138
name: sec_per_week
type: SBMLUnitsDef

120216
unit: 120242
unit: 120229
name: cm_week
type: SBMLUnitsDef

120320
unit: 120333
name: m2
type: SBMLUnitsDef

120151
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120073
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name: normalised
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120294
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metaid_0000008
constant: true
units: 120099
value: 1.0
name: Dose_Int2
type: Parameter

metaid_0000004
constant: false
units: 120099
value: NaN
name: rem_time
type: Parameter

120229
exponent: 1.0
scale: -2
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kind: METRE
type: SBMLUnit

metaid_0000021
constant: true
units: 120216
value: 21.8
name: T_Turnover
type: Parameter

120138
exponent: 1.0
scale: 0
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kind: SECOND
type: SBMLUnit