086268
stoichiometry: 1.0
species: metaid_0000013
type: SpeciesReference

metaid_0000013
has only substance units: false
in compartment: metaid_0000012
is version of: C00002
is version of: CHEBI:15422
type: Species
name: ATP
is: SBO:0000247
initial amount: NaN
initial concentration: 16.3
constant: false
boundary condition: false

metaid_0000006
constant: true
value: 25.0
name: Km2ATP
type: Parameter

086184
stoichiometry: 1.0
species: metaid_0000014
type: SpeciesReference

086318
stoichiometry: 1.0
species: metaid_0000017
type: SpeciesReference

metaid_0000016
is version of: IPR001697
is homolog to: O62619
name: Pyr
in compartment: metaid_0000012
constant: false
initial amount: NaN
type: Species
boundary condition: false
has only substance units: false
is: SBO:0000014
initial concentration: 0.0

metaid_0000020
kinetic law: 086244
product: 086232
reactant: 086220
reactant: 086208
is version of: R00127
fast: false
reversible: true
name: v2
type: Reaction

086220
stoichiometry: 1.0
species: metaid_0000014
type: SpeciesReference

metaid_0000009
constant: true
value: 65.0
name: Vmapp3
type: Parameter

metaid_0000019
kinetic law: 086196
product: 086184
reactant: 086172
is version of: R00086
fast: false
reversible: true
name: v1
type: Reaction

metaid_0000014
is: SBO:0000247
initial amount: NaN
boundary condition: false
in compartment: metaid_0000012
constant: false
initial concentration: 0.0
has only substance units: false
is version of: C00020
name: AMP
is version of: CHEBI:16027
type: Species

metaid_0000010
constant: true
value: 260.0
name: Kmapp3
type: Parameter

metaid_0000005
constant: true
value: 170.0
name: Vm2
type: Parameter

BIOMD0000000231
parameter: metaid_0000009
reaction: metaid_0000022
occurs in: http://identifiers.org/taxonomy/9913
parameter: metaid_0000011
parameter: metaid_0000010
parameter: metaid_0000005
species: metaid_0000015
reaction: metaid_0000020
parameter: metaid_0000007
is: MODEL5952687775
notes: This a model from the article: A kinetic study of a ternary cycle between adenine nucleotides. Valero E, Varón R, García-Carmona F FEBS J. [2006 Aug;273(15):3598-613 16884499 , Abstract: In the present paper, a kinetic study is made of the behavior of a moiety-conserved ternary cycle between the adenine nucleotides. The system contains the enzymes S-acetyl coenzyme A synthetase, adenylate kinase and pyruvate kinase, and converts ATP into AMP, then into ADP and finally back to ATP. L-Lactate dehydrogenase is added to the system to enable continuous monitoring of the progress of the reaction. The cycle cannot work when the only recycling substrate in the reaction medium is AMP. A mathematical model is proposed whose kinetic behavior has been analyzed both numerically by integration of the nonlinear differential equations describing the kinetics of the reactions involved, and analytically under steady-state conditions, with good agreement with the experimental results being obtained. The data obtained showed that there is a threshold value of the S-acetyl coenzyme A synthetase/adenylate kinase ratio, above which the cycle stops because all the recycling substrate has been accumulated as AMP, never reaching the steady state. In addition, the concept of adenylate energy charge has been applied to the system, obtaining the enabled values of the rate constants for a fixed adenylate energy charge value and vice versa.
species: metaid_0000016
parameter: metaid_0000008
reaction: metaid_0000019
substance units: metaid_0000077
species: metaid_0000017
time units: metaid_0000003
is version of: REACT 2124
area units: metaid_0000005
parameter: metaid_0000004
species: metaid_0000013
species: metaid_0000018
volume units: metaid_0000004
species: metaid_0000014
modified:
  W3 CDTF: Fri Mar 09 11:40:35 GMT 2012
is version of: GO:0046085
name: Valero2006_Adenine_TernaryCycle
compartment: metaid_0000012
is described by: http://identifiers.org/pubmed/16884499
curated: true
parameter: metaid_0000006
creator:
  ORG:
    orgname: EMBL-EBI
  n:
    given: Vijayalakshmi
    family: Chelliah
creator:
  ORG:
    orgname: University of Castilla-La Mancha, 02071 Albaceta, Spain.
  n:
    given: Edelmira
    family: Valero
type: SBMLModel
created:
  W3 CDTF: Wed Aug 19 17:30:30 BST 2009
length unit: length
reaction: metaid_0000021
parameter: metaid_0000003

metaid_0000015
in compartment: metaid_0000012
name: ADP
boundary condition: false
is: SBO:0000247
is version of: C00008
constant: false
initial concentration: 0.0
initial amount: NaN
type: Species
has only substance units: false
is version of: CHEBI:16761

metaid_0000008
constant: true
value: 71000.0
name: K
type: Parameter

metaid_0000021
kinetic law: 086292
product: 086280
product: 086268
reactant: 086256
is version of: R00200
fast: false
reversible: true
name: v3
type: Reaction

086208
stoichiometry: 1.0
species: metaid_0000013
type: SpeciesReference

metaid_0000011
constant: true
value: 5.0
name: k4
type: Parameter

metaid_0000004
constant: true
value: 700.0
name: Kmapp1
type: Parameter

metaid_0000018
initial concentration: 0.0
is version of: IPR011304
constant: true
initial amount: NaN
in compartment: metaid_0000012
type: Species
is: SBO:0000014
boundary condition: true
is version of: Q2KJG0
has only substance units: false
name: Lac

086256
stoichiometry: 1.0
species: metaid_0000015
type: SpeciesReference

086172
stoichiometry: 1.0
species: metaid_0000013
type: SpeciesReference

086280
stoichiometry: 1.0
species: metaid_0000016
type: SpeciesReference

metaid_0000022
kinetic law: 086342
product: 086330
reactant: 086318
reactant: 086305
is version of: R00703
fast: false
reversible: true
name: v4
type: Reaction

086232
stoichiometry: 2.0
species: metaid_0000015
type: SpeciesReference

metaid_0000012
constant: true
size: 1.0
spatial dimensions: 3.0
name: compartment
type: Compartment

086330
stoichiometry: 1.0
species: metaid_0000018
type: SpeciesReference

086305
stoichiometry: 1.0
species: metaid_0000016
type: SpeciesReference

metaid_0000003
constant: true
value: 2.3
name: Vmapp1
type: Parameter

metaid_0000017
has only substance units: false
in compartment: metaid_0000012
is: SBO:0000247
boundary condition: false
name: NADH
is version of: C00004
constant: false
initial amount: NaN
initial concentration: 256.0
type: Species
is version of: CHEBI:16908

metaid_0000007
constant: true
value: 110.0
name: Km2AMP
type: Parameter