742941
stoichiometry: 1.0
species: metaid_0000105
type: SpeciesReference

743073
stoichiometry: 1.0
species: metaid_0000085
type: SpeciesReference

metaid_0000062
constant: true
value: 0.001
name: k_24
type: Parameter

metaid_0000162
kinetic law: 743387
product: 743375
reactant: 743363
reactant: 743351
fast: false
reversible: true
type: Reaction

742796
stoichiometry: 1.0
species: metaid_0000088
type: SpeciesReference

metaid_0000176
constant: false
value: NaN
name: C3 fraction
type: Parameter

metaid_0000037
constant: true
value: 1.0E-6
name: k14
type: Parameter

metaid_0000189
is version of: Q07812
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: metaid_0000188
name: Baxm
type: Species

metaid_0000076
constant: false
notes: TRAIL receptor : for experiments without siRNA R = 200
is version of: REACT 2540
type: Species
has only substance units: false
initial concentration: NaN
is version of: O14763
name: R
in compartment: metaid_0000074
initial amount: 200.0
boundary condition: false

metaid_0000123
is version of: REACT 5375
type: Species
initial concentration: NaN
name: Smac released
constant: false
has only substance units: false
initial amount: 0.0
in compartment: metaid_0000188
boundary condition: false
notes: Smac released into the mitochondrial intermembrane space
is version of: Q9NR28

metaid_0000094
in compartment: metaid_0000074
initial amount: 0.0
has only substance units: false
constant: false
boundary condition: false
initial concentration: NaN
type: Species
notes: activated Bax
is version of: Q07812
name: Bax#

metaid_0000023
constant: true
value: 0.1
name: kc8
type: Parameter

743777
stoichiometry: 1.0
species: metaid_0000126
type: SpeciesReference

metaid_0000137
kinetic law: 742196
product: 742184
product: 742172
reactant: 742160
is part of: REACT 961
fast: false
reversible: false
type: Reaction

metaid_0000133
kinetic law: 742016
product: 742004
reactant: 741992
reactant: 741980
is version of: GO:0045569
fast: false
reversible: true
type: Reaction

743375
stoichiometry: 1.0
species: metaid_0000116
type: SpeciesReference

743279
stoichiometry: 1.0
species: metaid_0000190
type: SpeciesReference

metaid_0000175
constant: false
value: NaN
name: pC3 fraction
type: Parameter

metaid_0000063
constant: true
value: 5.0E-9
name: k25
type: Parameter

742280
stoichiometry: 1.0
species: metaid_0000080
type: SpeciesReference

metaid_0000161
kinetic law: 743339
product: 743327
reactant: 743315
reactant: 743303
fast: false
reversible: true
type: Reaction

742232
stoichiometry: 1.0
species: metaid_0000101
type: SpeciesReference

metaid_0000036
constant: true
value: 0.01
name: k_13
type: Parameter

metaid_0000124
in compartment: metaid_0000188
boundary condition: false
name: CytoC_m
initial amount: 500000.0
is version of: REACT_14114
is version of: P99999
constant: false
has only substance units: false
initial concentration: NaN
type: Species

742712
stoichiometry: 1.0
species: metaid_0000080
type: SpeciesReference

742412
stoichiometry: 1.0
species: metaid_0000079
type: SpeciesReference

metaid_0000109
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: metaid_0000074
name: PARP:C3
type: Species

metaid_0000022
constant: true
value: 0.001
name: k_8
type: Parameter

742953
stoichiometry: 1.0
species: metaid_0000110
type: SpeciesReference

743448
stoichiometry: 1.0
species: metaid_0000115
type: SpeciesReference

742004
stoichiometry: 1.0
species: metaid_0000097
type: SpeciesReference

metaid_0000077
in compartment: metaid_0000074
has only substance units: false
is described by: http://identifiers.org/omim/603599
is version of: REACT 2438
initial amount: 100.0
initial concentration: NaN
boundary condition: false
is version of: O15519
constant: false
type: Species
name: flip

741992
stoichiometry: 1.0
species: metaid_0000076
type: SpeciesReference

metaid_0000134
kinetic law: 742052
product: 742040
reactant: 742028
fast: false
reversible: false
type: Reaction

metaid_0000138
kinetic law: 742244
product: 742232
reactant: 742220
reactant: 742208
fast: false
reversible: true
type: Reaction

743686
stoichiometry: 1.0
species: metaid_0000124
type: SpeciesReference

742184
stoichiometry: 1.0
species: metaid_0000098
type: SpeciesReference

742784
stoichiometry: 1.0
species: metaid_0000108
type: SpeciesReference

metaid_0000174
kinetic law: 743949
product: 743937
reactant: 743925
reactant: 743913
fast: false
reversible: true
type: Reaction

742893
stoichiometry: 1.0
species: metaid_0000090
type: SpeciesReference

metaid_0000049
constant: true
value: 1.0
name: kc19
type: Parameter

metaid_0000060
constant: true
value: 1.0
name: kc23
type: Parameter

743460
stoichiometry: 1.0
species: metaid_0000118
type: SpeciesReference

742328
stoichiometry: 1.0
species: metaid_0000102
type: SpeciesReference

metaid_0000050
constant: true
value: 2.0E-6
name: k20
type: Parameter

743608
stoichiometry: 1.0
species: metaid_0000123
type: SpeciesReference

743841
stoichiometry: 1.0
species: metaid_0000129
type: SpeciesReference

metaid_0000039
constant: true
value: 1.0E-6
name: k15
type: Parameter

743937
stoichiometry: 1.0
species: metaid_0000105
type: SpeciesReference

metaid_0000164
kinetic law: 743484
product: 743472
reactant: 743460
reactant: 743448
fast: false
reversible: true
type: Reaction

metaid_0000021
constant: true
value: 2.0E-6
name: k8
type: Parameter

metaid_0000011
constant: true
value: 1.0E-6
name: k4
type: Parameter

743673
stoichiometry: 1.0
species: metaid_0000120
type: SpeciesReference

metaid_0000149
kinetic law: 742772
product: 742760
reactant: 742748
reactant: 742736
fast: false
reversible: true
type: Reaction

742809
stoichiometry: 1.0
species: metaid_0000087
type: SpeciesReference

metaid_0000121
initial concentration: NaN
type: Species
initial amount: 100000.0
has only substance units: false
constant: false
name: Smac_m
in compartment: metaid_0000188
is version of: Q9NR28
boundary condition: false
is version of: REACT 5499

metaid_0000088
type: Species
initial concentration: NaN
constant: false
notes: ubiquitinylated caspase 3
boundary condition: false
has version: P62988
name: Ub C3
in compartment: metaid_0000074
has only substance units: false
initial amount: 0.0
has version: P42574

metaid_0000092
has only substance units: false
in compartment: metaid_0000074
boundary condition: false
is version of: REACT 3598
initial concentration: NaN
constant: false
is version of: P10415
name: cytosolic Bcl-2
type: Species
initial amount: 20000.0

742496
stoichiometry: 1.0
species: metaid_0000106
type: SpeciesReference

metaid_0000139
kinetic law: 742292
product: 742280
product: 742268
reactant: 742256
fast: false
reversible: false
type: Reaction

metaid_0000135
kinetic law: 742100
product: 742088
reactant: 742076
reactant: 742064
fast: false
reversible: true
type: Reaction

metaid_0000078
has only substance units: false
is version of: Q14790
name: proC8
constant: false
initial concentration: NaN
boundary condition: false
type: Species
is version of: REACT 4998.1
initial amount: 20000.0
in compartment: metaid_0000074

metaid_0000048
constant: true
value: 0.001
name: k_19
type: Parameter

metaid_0000173
kinetic law: 743901
product: 743889
product: 743877
reactant: 743865
fast: false
reversible: false
type: Reaction

metaid_0000061
constant: true
value: 5.0E-8
name: k24
type: Parameter

743725
stoichiometry: 1.0
species: metaid_0000125
type: SpeciesReference

743363
stoichiometry: 1.0
species: metaid_0000190
type: SpeciesReference

metaid_0000051
constant: true
value: 0.001
name: k_20
type: Parameter

metaid_0000163
kinetic law: 743435
product: 743423
reactant: 743411
reactant: 743399
fast: false
reversible: true
type: Reaction

metaid_0000038
constant: true
value: 0.001
name: k_14
type: Parameter

741980
stoichiometry: 1.0
species: metaid_0000075
type: SpeciesReference

metaid_0000020
constant: true
value: 0.001
name: k_7
type: Parameter

metaid_0000089
is version of: P09874
in compartment: metaid_0000074
initial amount: 1000000.0
has only substance units: false
initial concentration: NaN
boundary condition: false
type: Species
name: PARP
notes: EC substrate
constant: false

metaid_0000122
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: metaid_0000188
name: M#:Smac_m
type: Species

metaid_0000093
is version of: Q07812
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 100000.0
in compartment: metaid_0000074
name: Bax
type: Species

metaid_0000079
is version of: REACT 4185
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: metaid_0000074
name: casp8
type: Species

metaid_0000136
kinetic law: 742148
product: 742136
reactant: 742124
reactant: 742112
is part of: REACT 961
fast: false
reversible: true
type: Reaction

743025
stoichiometry: 1.0
species: metaid_0000085
type: SpeciesReference

742424
stoichiometry: 1.0
species: metaid_0000083
type: SpeciesReference

metaid_0000010
constant: true
value: 1.0
name: kc3
type: Parameter

743634
stoichiometry: 1.0
species: metaid_0000123
type: SpeciesReference

metaid_0000052
constant: true
value: 10.0
name: kc20
type: Parameter

metaid_0000066
constant: true
value: 0.01
name: k26
type: Parameter

743699
stoichiometry: 1.0
species: metaid_0000125
type: SpeciesReference

743423
stoichiometry: 1.0
species: metaid_0000117
type: SpeciesReference

metaid_0000033
constant: true
value: 0.001
name: k_12
type: Parameter

metaid_0000047
constant: true
value: 1.0E-6
name: k19
type: Parameter

metaid_0000172
kinetic law: 743853
product: 743841
reactant: 743829
reactant: 743816
fast: false
reversible: true
type: Reaction

743097
stoichiometry: 1.0
species: metaid_0000113
type: SpeciesReference

metaid_0000086
is version of: P55212
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 10000.0
in compartment: metaid_0000074
name: proC6
type: Species

metaid_0000027
constant: true
value: 1.0E-7
name: k10
type: Parameter

metaid_0000152
kinetic law: 742917
product: 742905
product: 742893
reactant: 742881
fast: false
reversible: false
type: Reaction

742076
stoichiometry: 1.0
species: metaid_0000077
type: SpeciesReference

742881
stoichiometry: 1.0
species: metaid_0000109
type: SpeciesReference

metaid_0000013
constant: true
value: 1.0E-7
name: k5
type: Parameter

742316
stoichiometry: 1.0
species: metaid_0000081
type: SpeciesReference

743472
stoichiometry: 1.0
species: metaid_0000119
type: SpeciesReference

metaid_0000072
constant: true
value: 1.0
name: kc7
type: Parameter

metaid_0000067
constant: true
value: 0.01
name: k_26
type: Parameter

743647
stoichiometry: 1.0
species: metaid_0000091
type: SpeciesReference

743133
stoichiometry: 1.0
species: metaid_0000085
type: SpeciesReference

metaid_0000100
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: metaid_0000074
name: R#:pC8
type: Species

742568
stoichiometry: 1.0
species: metaid_0000104
type: SpeciesReference

metaid_0000053
constant: true
value: 2.0E-6
name: k21
type: Parameter

743037
stoichiometry: 1.0
species: metaid_0000092
type: SpeciesReference

742112
stoichiometry: 1.0
species: metaid_0000098
type: SpeciesReference

metaid_0000090
type: Species
is version of: P09874
initial amount: 0.0
in compartment: metaid_0000074
initial concentration: NaN
name: cPARP
has only substance units: false
boundary condition: false
notes: cleaved PARP
constant: false

742977
stoichiometry: 1.0
species: metaid_0000087
type: SpeciesReference

742028
stoichiometry: 1.0
species: metaid_0000097
type: SpeciesReference

metaid_0000171
kinetic law: 743803
product: 743790
reactant: 743777
fast: false
reversible: true
type: Reaction

742604
stoichiometry: 1.0
species: metaid_0000083
type: SpeciesReference

metaid_0000032
constant: true
value: 1.0E-7
name: k12
type: Parameter

metaid_0000046
constant: true
value: 0.001
name: k_18
type: Parameter

metaid_0000110
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: metaid_0000074
name: Apop:XIAP
type: Species

742160
stoichiometry: 1.0
species: metaid_0000100
type: SpeciesReference

742905
stoichiometry: 1.0
species: metaid_0000083
type: SpeciesReference

743399
stoichiometry: 1.0
species: metaid_0000096
type: SpeciesReference

metaid_0000026
constant: true
value: 1.0
name: kc9
type: Parameter

metaid_0000120
notes: opened inner mitochondrial membrane pore
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: metaid_0000188
name: M#
type: Species

metaid_0000151
kinetic law: 742869
product: 742857
reactant: 742845
reactant: 742833
fast: false
reversible: true
type: Reaction

metaid_0000087
initial concentration: NaN
is version of: P98170
constant: false
type: Species
has only substance units: false
boundary condition: false
initial amount: 100000.0
name: XIAP
is version of: REACT 5246
in compartment: metaid_0000074

metaid_0000073
constant: true
value: 0.07
name: v
type: Parameter

metaid_0000091
is version of: Q9NR28
boundary condition: false
in compartment: metaid_0000074
has only substance units: false
type: Species
initial concentration: NaN
is version of: REACT 5375
initial amount: 0.0
name: Smac
constant: false

metaid_0000130
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: metaid_0000074
name: Apaf#
type: Species

743534
stoichiometry: 1.0
species: metaid_0000120
type: SpeciesReference

743327
stoichiometry: 1.0
species: metaid_0000115
type: SpeciesReference

metaid_0000012
constant: true
value: 0.001
name: k_4
type: Parameter

metaid_0000035
constant: true
value: 0.01
name: k13
type: Parameter

metaid_0000190
initial concentration: NaN
constant: false
name: Bax2
has only substance units: false
boundary condition: false
has part: Q07812
in compartment: metaid_0000188
initial amount: 0.0
notes: dimeric Bax
type: Species

metaid_0000160
kinetic law: 743291
product: 743279
reactant: 743267
reactant: 743255
fast: false
reversible: true
type: Reaction

metaid_0000054
constant: true
value: 0.001
name: k_21
type: Parameter

metaid_0000064
constant: true
value: 0.001
name: k_25
type: Parameter

742472
stoichiometry: 1.0
species: metaid_0000106
type: SpeciesReference

metaid_0000111
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: metaid_0000074
name: Smac:XIAP
type: Species

743411
stoichiometry: 1.0
species: metaid_0000115
type: SpeciesReference

metaid_0000170
kinetic law: 743764
product: 743751
product: 743738
reactant: 743725
fast: false
reversible: false
type: Reaction

metaid_0000045
constant: true
value: 1.0E-6
name: k18
type: Parameter

metaid_0000180
constant: false
value: NaN
name: total Caspase 3
type: Parameter

742088
stoichiometry: 1.0
species: metaid_0000099
type: SpeciesReference

metaid_0000150
kinetic law: 742821
product: 742809
product: 742796
reactant: 742784
fast: false
reversible: false
type: Reaction

metaid_0000084
initial amount: 40000.0
in compartment: metaid_0000074
boundary condition: false
is version of: P55957
name: Bid
is described by: http://identifiers.org/omim/601997
initial concentration: NaN
has only substance units: false
is version of: REACT 3224
constant: false
type: Species

742304
stoichiometry: 1.0
species: metaid_0000079
type: SpeciesReference

metaid_0000025
constant: true
value: 0.01
name: k_9
type: Parameter

742640
stoichiometry: 1.0
species: metaid_0000083
type: SpeciesReference

743085
stoichiometry: 1.0
species: metaid_0000093
type: SpeciesReference

metaid_0000131
is version of: P55211
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 100000.0
in compartment: metaid_0000074
name: proC9
type: Species

metaid_0000140
kinetic law: 742340
product: 742328
reactant: 742316
reactant: 742304
fast: false
reversible: true
type: Reaction

metaid_0000015
constant: true
value: 1.0
name: kc5
type: Parameter

metaid_0000074
is: GO:0005829
constant: true
size: 1.0
spatial dimensions: 3.0
name: cell
type: Compartment

metaid_0000034
constant: true
value: 1.0
name: kc12
type: Parameter

742989
stoichiometry: 1.0
species: metaid_0000091
type: SpeciesReference

742592
stoichiometry: 1.0
species: metaid_0000104
type: SpeciesReference

742172
stoichiometry: 1.0
species: metaid_0000079
type: SpeciesReference

742616
stoichiometry: 1.0
species: metaid_0000105
type: SpeciesReference

743121
stoichiometry: 1.0
species: metaid_0000113
type: SpeciesReference

metaid_0000055
constant: true
value: 10.0
name: kc21
type: Parameter

metaid_0000065
constant: true
value: 1.0
name: kc25
type: Parameter

743049
stoichiometry: 1.0
species: metaid_0000112
type: SpeciesReference

metaid_0000112
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: metaid_0000074
name: Bcl2c:tBid
type: Species

742700
stoichiometry: 1.0
species: metaid_0000083
type: SpeciesReference

742400
stoichiometry: 1.0
species: metaid_0000103
type: SpeciesReference

metaid_0000044
constant: true
value: 0.001
name: k_17
type: Parameter

743509
stoichiometry: 1.0
species: metaid_0000120
type: SpeciesReference

metaid_0000085
initial concentration: NaN
name: tBid
has only substance units: false
is version of: REACT 385
constant: false
boundary condition: false
type: Species
is version of: P55957
initial amount: 0.0
in compartment: metaid_0000074

742220
stoichiometry: 1.0
species: metaid_0000078
type: SpeciesReference

metaid_0000024
constant: true
value: 1.0E-6
name: k9
type: Parameter

metaid_0000014
constant: true
value: 0.001
name: k_5
type: Parameter

metaid_0000075
initial concentration: NaN
is version of: P50591
notes: TRAIL : L = 3000 correspond to 50 ng/ml SuperKiller TRAIL for experiments under saturating conditions use L = 60000
constant: false
is version of: REACT 3803
has only substance units: false
boundary condition: false
initial amount: 3000.0
type: Species
name: L
in compartment: metaid_0000074

metaid_0000156
kinetic law: 743109
product: 743097
reactant: 743085
reactant: 743073
fast: false
reversible: true
type: Reaction

metaid_0000142
kinetic law: 742436
product: 742424
product: 742412
reactant: 742400
is version of: http://identifiers.org/ec-code/3.4.22.61
fast: false
reversible: false
type: Reaction

743303
stoichiometry: 1.0
species: metaid_0000190
type: SpeciesReference

742364
stoichiometry: 1.0
species: metaid_0000079
type: SpeciesReference

metaid_0000004
constant: true
value: 0.001
name: k_1
type: Parameter

743231
stoichiometry: 1.0
species: metaid_0000114
type: SpeciesReference

metaid_0000018
constant: true
value: 1.0
name: kc6
type: Parameter

metaid_0000083
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: metaid_0000074
name: casp3
type: Species

743816
stoichiometry: 1.0
species: metaid_0000127
type: SpeciesReference

metaid_0000102
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: metaid_0000074
name: BAR:C8
type: Species

742136
stoichiometry: 1.0
species: metaid_0000100
type: SpeciesReference

metaid_0000056
constant: true
value: 0.01
name: k22
type: Parameter

742064
stoichiometry: 1.0
species: metaid_0000098
type: SpeciesReference

742544
stoichiometry: 1.0
species: metaid_0000082
type: SpeciesReference

742833
stoichiometry: 1.0
species: metaid_0000089
type: SpeciesReference

742929
stoichiometry: 1.0
species: metaid_0000087
type: SpeciesReference

metaid_0000043
constant: true
value: 1.0E-6
name: k17
type: Parameter

metaid_0000155
kinetic law: 743061
product: 743049
reactant: 743037
reactant: 743025
fast: false
reversible: true
type: Reaction

742664
stoichiometry: 1.0
species: metaid_0000107
type: SpeciesReference

metaid_0000141
kinetic law: 742388
product: 742376
reactant: 742364
reactant: 742352
fast: false
reversible: true
type: Reaction

743889
stoichiometry: 1.0
species: metaid_0000130
type: SpeciesReference

metaid_0000005
constant: true
value: 1.0E-5
name: kc1
type: Parameter

742208
stoichiometry: 1.0
species: metaid_0000080
type: SpeciesReference

743738
stoichiometry: 1.0
species: metaid_0000126
type: SpeciesReference

metaid_0000082
is version of: P42574
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 10000.0
in compartment: metaid_0000074
name: proC3
type: Species

metaid_0000169
kinetic law: 743712
product: 743699
reactant: 743686
reactant: 743673
fast: false
reversible: true
type: Reaction

metaid_0000129
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: metaid_0000074
name: CytoC:Apaf
type: Species

metaid_0000101
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: metaid_0000074
name: C6:pC8
type: Species

metaid_0000057
constant: true
value: 0.01
name: k_22
type: Parameter

metaid_0000019
constant: true
value: 3.0E-8
name: k7
type: Parameter

743583
stoichiometry: 1.0
species: metaid_0000122
type: SpeciesReference

metaid_0000119
has part: Q07812
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: metaid_0000188
name: Bax4:M
type: Species

metaid_0000042
constant: true
value: 0.001
name: k_16
type: Parameter

743219
stoichiometry: 1.0
species: metaid_0000096
type: SpeciesReference

metaid_0000006
constant: true
value: 1.0E-6
name: k2
type: Parameter

metaid_0000071
constant: true
value: 0.001
name: k_28
type: Parameter

metaid_0000154
kinetic law: 743013
product: 743001
reactant: 742989
reactant: 742977
fast: false
reversible: true
type: Reaction

metaid_0000081
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 1000.0
in compartment: metaid_0000074
name: BAR
type: Species

metaid_0000144
kinetic law: 742532
product: 742520
product: 742508
reactant: 742496
is version of: http://identifiers.org/ec-code/3.4.22.61
fast: false
reversible: false
type: Reaction

743315
stoichiometry: 1.0
species: metaid_0000190
type: SpeciesReference

ORG:
  orgname: Institut Curie
n:
  given: Simon
  family: Fourquet

742376
stoichiometry: 1.0
species: metaid_0000103
type: SpeciesReference

metaid_0000016
constant: true
value: 1.0E-6
name: k6
type: Parameter

743181
stoichiometry: 1.0
species: metaid_0000189
type: SpeciesReference

metaid_0000104
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: metaid_0000074
name: pC3:Apop
type: Species

metaid_0000058
constant: true
value: 5.0E-7
name: k23
type: Parameter

742556
stoichiometry: 1.0
species: metaid_0000105
type: SpeciesReference

metaid_0000031
constant: true
value: 0.001
name: k_11
type: Parameter

742124
stoichiometry: 1.0
species: metaid_0000078
type: SpeciesReference

metaid_0000041
constant: true
value: 1.0E-6
name: k16
type: Parameter

metaid_0000118
notes: binding sites for activated Bax on the inner mitochondrial membrane
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 500000.0
in compartment: metaid_0000188
name: M
type: Species

743145
stoichiometry: 1.0
species: metaid_0000094
type: SpeciesReference

metaid_0000068
constant: true
value: 2.0E-6
name: k27
type: Parameter

metaid_0000007
constant: true
value: 0.001
name: k_2
type: Parameter

metaid_0000003
constant: true
value: 4.0E-7
name: k1
type: Parameter

metaid_0000070
constant: true
value: 7.0E-6
name: k28
type: Parameter

metaid_0000117
name: Bax4:Bcl2
type: Species
has only substance units: false
initial concentration: NaN
initial amount: 0.0
constant: false
has part: Q07812
in compartment: metaid_0000188
boundary condition: false
has part: P10415

metaid_0000143
kinetic law: 742484
product: 742472
reactant: 742460
reactant: 742448
fast: false
reversible: true
type: Reaction

metaid_0000080
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: metaid_0000074
name: casp6
type: Species

743877
stoichiometry: 1.0
species: metaid_0000127
type: SpeciesReference

742652
stoichiometry: 1.0
species: metaid_0000086
type: SpeciesReference

metaid_0000153
kinetic law: 742965
product: 742953
reactant: 742941
reactant: 742929
fast: false
reversible: true
type: Reaction

metaid_0000017
constant: true
value: 0.001
name: k_6
type: Parameter

metaid_0000103
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: metaid_0000074
name: C8:pC3
type: Species

743497
stoichiometry: 1.0
species: metaid_0000119
type: SpeciesReference

metaid_0000184
constant: false
value: NaN
name: free C3 fraction
type: Parameter

metaid_0000059
constant: true
value: 0.001
name: k_23
type: Parameter

metaid_0000030
constant: true
value: 1.0E-6
name: k11
type: Parameter

metaid_0000040
constant: true
value: 0.001
name: k_15
type: Parameter

metaid_0000069
constant: true
value: 0.001
name: k_27
type: Parameter

742736
stoichiometry: 1.0
species: metaid_0000083
type: SpeciesReference

742508
stoichiometry: 1.0
species: metaid_0000085
type: SpeciesReference

743546
stoichiometry: 1.0
species: metaid_0000121
type: SpeciesReference

metaid_0000146
kinetic law: 742628
product: 742616
product: 742604
reactant: 742592
fast: false
reversible: false
type: Reaction

metaid_0000126
constant: false
has only substance units: false
is version of: REACT 3942
type: Species
notes: cytochrom C released into the mitochondrial intermembrane space
boundary condition: false
name: CytoC released
in compartment: metaid_0000188
initial concentration: NaN
initial amount: 0.0
is version of: P99999

metaid_0000099
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: metaid_0000074
name: flip:R#
type: Species

metaid_0000116
has only substance units: false
type: Species
boundary condition: false
name: Bax2:Bcl2
has part: P10415
initial amount: 0.0
in compartment: metaid_0000188
has part: Q07812
constant: false
initial concentration: NaN

742040
stoichiometry: 1.0
species: metaid_0000098
type: SpeciesReference

742460
stoichiometry: 1.0
species: metaid_0000084
type: SpeciesReference

742520
stoichiometry: 1.0
species: metaid_0000079
type: SpeciesReference

742857
stoichiometry: 1.0
species: metaid_0000109
type: SpeciesReference

metaid_0000008
constant: true
value: 1.0E-6
name: k3
type: Parameter

metaid_0000028
constant: true
value: 0.001
name: k_10
type: Parameter

743255
stoichiometry: 1.0
species: metaid_0000189
type: SpeciesReference

742256
stoichiometry: 1.0
species: metaid_0000101
type: SpeciesReference

743207
stoichiometry: 1.0
species: metaid_0000189
type: SpeciesReference

743596
stoichiometry: 1.0
species: metaid_0000120
type: SpeciesReference

BIOMD0000000220
parameter: metaid_0000062
reaction: metaid_0000154
species: metaid_0000116
reaction: metaid_0000147
reaction: metaid_0000149
area units: metaid_0000005
parameter: metaid_0000056
parameter: metaid_0000007
species: metaid_0000104
species: metaid_0000131
reaction: metaid_0000159
parameter: metaid_0000072
reaction: metaid_0000143
species: metaid_0000094
rule: metaid_0000186
species: metaid_0000124
reaction: metaid_0000161
parameter: metaid_0000052
is version of: hsa04210
name: Albeck2008_extrinsic_apoptosis
reaction: metaid_0000155
parameter: metaid_0000057
species: metaid_0000086
species: metaid_0000130
species: metaid_0000112
parameter: metaid_0000073
reaction: metaid_0000173
species: metaid_0000093
species: metaid_0000079
parameter: metaid_0000069
rule: metaid_0000181
species: metaid_0000080
parameter: metaid_0000053
parameter: metaid_0000048
species: metaid_0000100
reaction: metaid_0000156
is version of: REACT 1059
species: metaid_0000085
reaction: metaid_0000174
parameter: metaid_0000065
volume units: metaid_0000069
parameter: metaid_0000044
parameter: metaid_0000177
parameter: metaid_0000058
species: metaid_0000106
reaction: metaid_0000166
parameter: metaid_0000024
reaction: metaid_0000170
parameter: metaid_0000061
compartment: metaid_0000188
parameter: metaid_0000040
reaction: metaid_0000163
parameter: metaid_0000054
reaction: metaid_0000146
reaction: metaid_0000150
parameter: metaid_0000178
time units: 809101
parameter: metaid_0000059
parameter: metaid_0000070
parameter: metaid_0000020
reaction: metaid_0000142
parameter: metaid_0000050
species: metaid_0000189
species: metaid_0000129
species: metaid_0000082
species: metaid_0000076
parameter: metaid_0000055
species: metaid_0000120
parameter: metaid_0000071
reaction: metaid_0000137
reaction: metaid_0000171
species: metaid_0000087
parameter: metaid_0000067
parameter: metaid_0000051
parameter: metaid_0000046
reaction: metaid_0000151
parameter: metaid_0000184
is: MODEL6964793701
parameter: metaid_0000028
species: metaid_0000081

metaid_0000106
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: metaid_0000074
name: C8:Bid
type: Species

metaid_0000166
kinetic law: 743570
product: 743558
reactant: 743546
reactant: 743534
fast: false
reversible: true
type: Reaction

metaid_0000125
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: metaid_0000188
name: M#:CytoC_m
type: Species

metaid_0000145
kinetic law: 742580
product: 742568
reactant: 742556
reactant: 742544
fast: false
reversible: true
type: Reaction

metaid_0000115
has only substance units: false
initial concentration: NaN
name: Bax4
type: Species
has part: Q07812
initial amount: 0.0
notes: Bax tetramer
boundary condition: false
constant: false
in compartment: metaid_0000188

metaid_0000098
initial concentration: NaN
constant: false
has only substance units: false
name: R#
initial amount: 0.0
notes: activated receptor
type: Species
in compartment: metaid_0000074
is version of: O14763
boundary condition: false

743351
stoichiometry: 1.0
species: metaid_0000096
type: SpeciesReference

metaid_0000159
kinetic law: 743243
product: 743231
reactant: 743219
reactant: 743207
fast: false
reversible: true
type: Reaction

742688
stoichiometry: 1.0
species: metaid_0000107
type: SpeciesReference

metaid_0000009
constant: true
value: 0.001
name: k_3
type: Parameter

743829
stoichiometry: 1.0
species: metaid_0000128
type: SpeciesReference

742760
stoichiometry: 1.0
species: metaid_0000108
type: SpeciesReference

743925
stoichiometry: 1.0
species: metaid_0000131
type: SpeciesReference

metaid_0000029
constant: true
value: 1.0
name: kc10
type: Parameter

metaid_0000165
kinetic law: 743521
product: 743509
reactant: 743497
fast: false
reversible: false
type: Reaction

743865
stoichiometry: 1.0
species: metaid_0000129
type: SpeciesReference

metaid_0000105
has part: P99999
initial concentration: NaN
has only substance units: false
boundary condition: false
initial amount: 0.0
is version of: GO:0043293
has part: P55211
in compartment: metaid_0000074
notes: apoptosome
name: Apop
is version of: REACT 5647
type: Species
constant: false
has part: O14727

metaid_0000128
is version of: O14727
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 100000.0
in compartment: metaid_0000074
name: Apaf
type: Species

742448
stoichiometry: 1.0
species: metaid_0000079
type: SpeciesReference

743558
stoichiometry: 1.0
species: metaid_0000122
type: SpeciesReference

742845
stoichiometry: 1.0
species: metaid_0000083
type: SpeciesReference

metaid_0000148
kinetic law: 742724
product: 742712
product: 742700
reactant: 742688
fast: false
reversible: false
type: Reaction

metaid_0000108
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: metaid_0000074
name: XIAP:C3
type: Species

metaid_0000158
kinetic law: 743194
product: 743181
reactant: 743169
fast: false
reversible: true
type: Reaction

metaid_0000097
notes: TRAIL-receptor complex
has only substance units: false
constant: false
name: L:R
is version of: REACT 5556
type: Species
initial amount: 0.0
has version: P50591
in compartment: metaid_0000074
boundary condition: false
initial concentration: NaN
has version: O14763

743169
stoichiometry: 1.0
species: metaid_0000094
type: SpeciesReference

metaid_0000114
has only substance units: false
name: Baxm:Bcl2
boundary condition: false
type: Species
has part: P10415
in compartment: metaid_0000188
has part: Q07812
initial amount: 0.0
initial concentration: NaN
constant: false

742748
stoichiometry: 1.0
species: metaid_0000087
type: SpeciesReference

743001
stoichiometry: 1.0
species: metaid_0000111
type: SpeciesReference

742268
stoichiometry: 1.0
species: metaid_0000079
type: SpeciesReference

metaid_0000178
constant: false
value: NaN
name: cPARP fraction
type: Parameter

metaid_0000168
kinetic law: 743660
product: 743647
reactant: 743634
fast: false
reversible: true
type: Reaction

743267
stoichiometry: 1.0
species: metaid_0000189
type: SpeciesReference

742352
stoichiometry: 1.0
species: metaid_0000082
type: SpeciesReference

metaid_0000127
is version of: P99999
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: metaid_0000074
name: CytoC
type: Species

743790
stoichiometry: 1.0
species: metaid_0000127
type: SpeciesReference

metaid_0000107
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: metaid_0000074
name: C3:pC6
type: Species

metaid_0000147
kinetic law: 742676
product: 742664
reactant: 742652
reactant: 742640
fast: false
reversible: true
type: Reaction

metaid_0000113
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: metaid_0000074
name: Bax:tBid
type: Species

metaid_0000096
has only substance units: false
initial amount: 20000.0
constant: false
type: Species
notes: mitochondrial Bcl-2
is version of: P10415
in compartment: metaid_0000188
name: Bcl-2
boundary condition: false
initial concentration: NaN

metaid_0000157
kinetic law: 743157
product: 743145
product: 743133
reactant: 743121
fast: false
reversible: false
type: Reaction

743751
stoichiometry: 1.0
species: metaid_0000120
type: SpeciesReference

metaid_0000188
is: GO:0005739
constant: true
size: 1.0
spatial dimensions: 3.0
name: mitochondrion
type: Compartment

metaid_0000177
constant: false
value: NaN
name: degraded C3 fraction
type: Parameter

metaid_0000167
kinetic law: 743621
product: 743608
product: 743596
reactant: 743583
fast: false
reversible: false
type: Reaction

743913
stoichiometry: 1.0
species: metaid_0000130
type: SpeciesReference

ORG:
  orgname: EMBL-EBI
n:
  given: Lukas
  family: Endler

W3 CDTF: Thu Jul 05 15:42:40 BST 2012

W3 CDTF: Wed Jul 01 18:12:55 BST 2009