metaid_0000016
constant: true
units: metaid_0000063
value: 0.02
type: Parameter

metaid_0000006
constant: false
units: metaid_0000065
value: 0.0
type: Parameter

metaid_0000026
constant: true
units: metaid_0000066
value: 0.025
type: Parameter

metaid_0000012
constant: true
units: metaid_0000065
value: 0.1
type: Parameter

312650
exponent: 1.0
scale: -6
multipler: 1.0
kind: MOLE
type: SBMLUnit

312722
exponent: -1.0
scale: 0
multipler: 60.0
kind: SECOND
type: SBMLUnit

312830
stoichiometry: 1.0
species: metaid_0000040
type: SpeciesReference

metaid_0000011
constant: false
units: metaid_0000065
value: 0.0
type: Parameter

metaid_0000063
unit: 312662
unit: 312650
name: uM
type: SBMLUnitsDef

metaid_0000041
substance units: dimensionless
initial concentration: NaN
constant: false
is version of: P24941
has only substance units: true
name: cdk2
type: Species
in compartment: metaid_0000035
boundary condition: false
initial amount: 0.0

metaid_0000003
constant: false
units: metaid_0000065
value: 0.0
type: Parameter

metaid_0000031
constant: true
units: dimensionless
value: 0.01
type: Parameter

312638
exponent: 1.0
scale: 0
multipler: 60.0
kind: SECOND
type: SBMLUnit

metaid_0000021
constant: true
units: dimensionless
value: 0.01
type: Parameter

metaid_0000007
constant: true
units: metaid_0000065
value: 0.1
type: Parameter

metaid_0000017
constant: true
units: metaid_0000065
value: 0.001
type: Parameter

metaid_0000023
constant: true
units: dimensionless
value: 0.01
type: Parameter

312686
exponent: -1.0
scale: 0
multipler: 60.0
kind: SECOND
type: SBMLUnit

metaid_0000027
constant: true
units: metaid_0000063
value: 0.02
type: Parameter

metaid_0000013
constant: true
units: metaid_0000066
value: 0.05
type: Parameter

metaid_0000047
kinetic law: 312758
modifier: 312746
product: 312734
is version of: GO:0004693
fast: false
reversible: false
name: cdk2 mediated cyclinB synthesis
type: Reaction

metaid_0000054
kinetic law: 312854
modifier: 312842
product: 312830
fast: false
reversible: false
name: cyclinE synthesis
type: Reaction

312662
exponent: -1.0
scale: 0
multipler: 1.0
kind: LITRE
type: SBMLUnit

312806
stoichiometry: 1.0
species: metaid_0000037
type: SpeciesReference

metaid_0000042
is version of: Q9UBT2
boundary condition: false
type: Species
initial concentration: NaN
in compartment: metaid_0000035
name: Ubiquitin ligase 2
has only substance units: true
initial amount: 0.0
substance units: dimensionless
constant: false

metaid_0000064
unit: 312674
name: micromole
type: SBMLUnitsDef

metaid_0000032
constant: true
units: dimensionless
value: 0.01
type: Parameter

metaid_0000037
name: cyclinB
type: Species
constant: false
substance units: metaid_0000064
is version of: Q8WWL7
initial concentration: 2.0
has only substance units: false
boundary condition: false
initial amount: NaN
in compartment: metaid_0000035

metaid_0000022
constant: true
units: metaid_0000065
value: 0.05
type: Parameter

312866
stoichiometry: 1.0
species: metaid_0000040
type: SpeciesReference

metaid_0000014
constant: true
units: dimensionless
value: 0.03
type: Parameter

metaid_0000024
constant: true
units: metaid_0000066
value: 0.05
type: Parameter

metaid_0000008
constant: false
units: metaid_0000065
value: 0.0
type: Parameter

metaid_0000033
constant: true
units: metaid_0000065
value: 0.05
type: Parameter

312734
stoichiometry: 1.0
species: metaid_0000037
type: SpeciesReference

metaid_0000028
constant: true
units: metaid_0000065
value: 0.001
type: Parameter

metaid_0000056
kinetic law: 312914
reactant: 312902
is version of: GO:0008054
fast: false
reversible: false
name: cyclinE degradation
type: Reaction

metaid_0000038
boundary condition: false
in compartment: metaid_0000035
is version of: P06493
substance units: dimensionless
has only substance units: true
type: Species
initial amount: 1.0
name: cdk1
constant: false
initial concentration: NaN

metaid_0000055
kinetic law: 312890
modifier: 312878
reactant: 312866
is version of: GO:0008054
fast: false
reversible: false
name: Ubiquitin ligase mediated cyclinE degradation
type: Reaction

metaid_0000048
kinetic law: 312794
modifier: 312782
reactant: 312770
is version of: GO:0008054
fast: false
reversible: false
name: Ubiquitin ligase mediated cyclinB degradation
type: Reaction

metaid_0000065
unit: 312686
name: min_1
type: SBMLUnitsDef

metaid_0000034
constant: true
units: dimensionless
value: 0.01
type: Parameter

metaid_0000019
constant: true
units: metaid_0000065
value: 0.15
type: Parameter

312710
exponent: -1.0
scale: 0
multipler: 1.0
kind: LITRE
type: SBMLUnit

metaid_0000005
constant: true
units: metaid_0000065
value: 0.3
type: Parameter

metaid_0000020
constant: true
units: dimensionless
value: 0.01
type: Parameter

BIOMD0000000207
parameter: metaid_0000030
parameter: metaid_0000025
parameter: metaid_0000010
parameter: metaid_0000013
parameter: metaid_0000004
parameter: metaid_0000008
parameter: metaid_0000033
parameter: metaid_0000028
species: metaid_0000042
parameter: metaid_0000016
units def: metaid_0000065
reaction: metaid_0000049
name: Romond1999_CellCycle
reaction: metaid_0000054
units def: metaid_0000064
length unit: length
rule: metaid_0000070
parameter: metaid_0000021
curated: true
parameter: metaid_0000024
rule: metaid_0000043
compartment: metaid_0000035
parameter: metaid_0000012
substance units: metaid_0000044
parameter: metaid_0000003
is: MODEL1111382868
parameter: metaid_0000007
is version of: hsa04110
parameter: metaid_0000032
parameter: metaid_0000027
parameter: metaid_0000015
parameter: metaid_0000019
notes: The model reproduces Fig 3 of the paper. Model successfully reproduced using MathSBML and Jarnac. To the extent possible under law, all copyright and related or neighbouring rights to this encoded model have been dedicated to the public domain worldwide. Please refer to CC0 Public Domain Dedication for more information. In summary, you are entitled to use this encoded model in absolutely any manner you deem suitable, verbatim, or with modification, alone or embedded it in a larger context, redistribute it, commercially or not, in a restricted way or not. To cite BioModels Database, please use: Li C, Donizelli M, Rodriguez N, Dharuri H, Endler L, Chelliah V, Li L, He E, Henry A, Stefan MI, Snoep JL, Hucka M, Le Novère N, Laibe C (2010) BioModels Database: An enhanced, curated and annotated resource for published quantitative kinetic models. BMC Syst Biol., 4:92.
is described by: http://identifiers.org/pubmed/10415827
reaction: metaid_0000048
creator:
  ORG:
    orgname: California Institute of Technology
  n:
    given: Harish
    family: Dharuri
created:
  W3 CDTF: Wed Sep 10 14:58:58 BST 2008
species: metaid_0000038
reaction: metaid_0000056
rule: metaid_0000071
units def: metaid_0000063
parameter: metaid_0000020
rule: metaid_0000046
units def: metaid_0000062
parameter: metaid_0000023
rule: metaid_0000044
species: metaid_0000037
parameter: metaid_0000006
rule: metaid_0000073
parameter: metaid_0000031
parameter: metaid_0000026
parameter: metaid_0000011
volume units: metaid_0000059
parameter: metaid_0000034
parameter: metaid_0000014
parameter: metaid_0000018
parameter: metaid_0000005
parameter: metaid_0000009
reaction: metaid_0000047
species: metaid_0000041
parameter: metaid_0000029
units def: metaid_0000066
occurs in: http://identifiers.org/taxonomy/2759
parameter: metaid_0000017
time units: metaid_0000062
type: SBMLModel
modified:
  W3 CDTF: Thu Jul 05 17:48:46 BST 2012
area units: metaid_0000005
species: metaid_0000039
is version of: GO:0000278
reaction: metaid_0000055
rule: metaid_0000045
species: metaid_0000040
parameter: metaid_0000022
rule: metaid_0000075

metaid_0000015
constant: true
units: metaid_0000066
value: 0.025
type: Parameter

metaid_0000025
constant: true
units: dimensionless
value: 0.03
type: Parameter

metaid_0000009
constant: true
units: metaid_0000063
value: 0.5
type: Parameter

metaid_0000029
constant: true
units: dimensionless
value: 0.01
type: Parameter

312902
stoichiometry: 1.0
species: metaid_0000040
type: SpeciesReference

312770
stoichiometry: 1.0
species: metaid_0000037
type: SpeciesReference

312698
exponent: 1.0
scale: -6
multipler: 1.0
kind: MOLE
type: SBMLUnit

metaid_0000049
kinetic law: 312818
reactant: 312806
is version of: GO:0008054
fast: false
reversible: false
name: cyclinB degradation
type: Reaction

metaid_0000010
constant: true
units: metaid_0000065
value: 0.3
type: Parameter

metaid_0000062
unit: 312638
name: minute
type: SBMLUnitsDef

metaid_0000039
initial concentration: NaN
initial amount: 0.0
substance units: dimensionless
type: Species
boundary condition: false
constant: false
name: ubiquitin ligase
has only substance units: true
in compartment: metaid_0000035
is version of: Q9UBT2

metaid_0000018
constant: true
units: dimensionless
value: 0.01
type: Parameter

metaid_0000066
unit: 312722
unit: 312710
unit: 312698
name: uM_min_1
type: SBMLUnitsDef

metaid_0000035
constant: true
size: 1.0
spatial dimensions: 3.0
type: Compartment

metaid_0000030
constant: true
units: metaid_0000065
value: 0.15
type: Parameter

metaid_0000004
constant: true
units: metaid_0000063
value: 0.5
type: Parameter

metaid_0000040
initial amount: NaN
type: Species
in compartment: metaid_0000035
boundary condition: false
substance units: metaid_0000064
constant: false
is version of: P24864
has only substance units: false
initial concentration: 0.0
name: cyclinE

312674
exponent: 1.0
scale: -6
multipler: 1.0
kind: MOLE
type: SBMLUnit