481171
type: Species
has part: CHEBI:16480
initial concentration: 0.0
in compartment: 481131
has part: P16068
has part: P19687
is: SBO:0000297
has only substance units: false
constant: false
boundary condition: false
initial amount: NaN

metaid_0000030
unit: 389673
name: micromole
type: SBMLUnitsDef

metaid_0020046
notes: micromolar extinction coefficient of the 5-coordinate ferrous species at 431 nm
constant: true
units: metaid_0020031
value: 0.11
name: ext_5coord
type: Parameter

metaid_0000045
constant: true
units: metaid_0000035
value: 1.6
name: k11
type: Parameter

metaid_0300046
notes: micromolar extinction coefficient of the 5-coordinate ferrous nitrosyl species at 431 nm
constant: true
units: metaid_0020031
value: 0.025
name: ext_5coord_NO
type: Parameter

389939
stoichiometry: 1.0
species: 481351
type: SpeciesReference

metaid_0000039
constant: true
units: metaid_0000035
value: 0.2
name: k5
type: Parameter

metaid_0000050
kinetic law: 389963
product: 389951
reactant: 389939
reactant: 389927
is: SBO:0000177
fast: false
reversible: true
name: r1slow
type: Reaction

481191
has part: CHEBI:16480
has part: P16068
has part: P19687
boundary condition: false
type: Species
has only substance units: false
initial concentration: 0.0
in compartment: 481131
is: SBO:0000297
initial amount: NaN
constant: false

390061
stoichiometry: 1.0
species: 481291
type: SpeciesReference

389758
exponent: 1.0
scale: 0
multipler: 1.0
kind: LITRE
type: SBMLUnit

389685
exponent: 1.0
scale: 0
multipler: 1.0
kind: LITRE
type: SBMLUnit

metaid_0000043
constant: true
units: metaid_0000031
value: 5.0
name: k9
type: Parameter

389709
exponent: -1.0
scale: 0
multipler: 1.0
kind: SECOND
type: SBMLUnit

481211
has version: P16068
in compartment: 481131
has version: P19687
boundary condition: false
initial amount: NaN
type: Species
has only substance units: false
initial concentration: 0.112
constant: false
is: SBO:0000297

481271
type: Species
boundary condition: false
initial concentration: 0.0
has part: P19687
initial amount: NaN
constant: false
is: SBO:0000297
has part: P16068
has only substance units: false
has part: CHEBI:16480
in compartment: 481131

BIOMD0000000198
species: 481231
parameter: metaid_0000038
is version of: GO:0007263
rule: 481413
is described by: http://identifiers.org/pubmed/8573563
occurs in: http://identifiers.org/taxonomy/9913
parameter: metaid_0000045
area units: metaid_0000005
time units: metaid_0000041
species: 481211
parameter: metaid_0300046
is version of: GO:0031282
units def: metaid_0000031
units def: metaid_0000035
species: 481351
parameter: metaid_0000036
parameter: metaid_0000042
reaction: metaid_0000052
species: 481191
parameter: metaid_0500046
parameter: metaid_0000041
species: 481271
modified:
  W3 CDTF: Wed May 16 11:00:59 BST 2012
parameter: metaid_0000044
parameter: metaid_0000037
reaction: metaid_0000053
creator:
  ORG:
    orgname: EMBL-EBI
  n:
    given: Lukas
    family: Endler
is: MODEL4779732381
creator:
  ORG:
    orgname: Department of Biological Chemistry, University of Michigan, Michigan
  n:
    given: James R
    family: Stone
species: 482411
type: SBMLModel
creator:
  ORG:
    orgname: Department of Biological Chemistry, University of Michigan, Michigan
  n:
    given: Michael A
    family: Marletta
species: 481171
parameter: metaid_0000040
rule: 581413
parameter: metaid_0000043
species: 481391
reaction: metaid_0000051
reaction: metaid_0000049
units def: metaid_0010031
units def: metaid_0020031
name: Stone1996_NOsGC
rule: 481412
created:
  W3 CDTF: Tue Oct 21 16:19:25 BST 2008
species: 481331
substance units: metaid_0000030
compartment: 481131
creator:
  ORG:
    orgname: EMBL-EBI
  n:
    given: Vijayalakshmi
    family: Chelliah
species: 481411
reaction: metaid_0000050
units def: metaid_0000030
notes: This features the two step binding of NO to soluble Guanylyl Cyclase as proposed byStone JR, Marletta MA. Biochemistry (1996) 35(4):1093-9 . There is a fast step binding scheme and a slow step binding scheme. The difference lies in the binding of a NO to a non-heme site on sGC, which may not necessarily be the same site of binding during the initial binding. The rates have been directly used models. This model originates from BioModels Database: A Database of Annotated Published Models. It is copyright (c) 2005-2009 The BioModels Team. For more information see the terms of use . To cite BioModels Database, please use Le Novère N., Bornstein B., Broicher A., Courtot M., Donizelli M., Dharuri H., Li L., Sauro H., Schilstra M., Shapiro B., Snoep J.L., Hucka M. (2006) BioModels Database: A Free, Centralized Database of Curated, Published, Quantitative Kinetic Models of Biochemical and Cellular Systems Nucleic Acids Res., 34: D689-D691.
parameter: metaid_0000034
volume units: metaid_0000040
parameter: metaid_0020046
parameter: metaid_0400046
curated: true
length unit: length
parameter: metaid_0000039
units def: metaid_0000032
species: 481311
species: 481291
reaction: metaid_0000048
parameter: metaid_0010046
reaction: metaid_0000047

389951
stoichiometry: 1.0
species: 481331
type: SpeciesReference

metaid_0400046
notes: micromolar extinction coefficient of the 6-coordinate ferrous nitrosyl species at 431 nm
constant: true
units: metaid_0020031
value: 0.064
name: ext_6coord_NO
type: Parameter

metaid_0000034
constant: true
units: metaid_0000031
value: 700.0
name: k1
type: Parameter

389721
exponent: 1.0
scale: -6
multipler: 1.0
kind: MOLE
type: SBMLUnit

389903
stoichiometry: 1.0
species: 481231
type: SpeciesReference

390073
stoichiometry: 1.0
species: 481271
type: SpeciesReference

481231
boundary condition: false
initial concentration: 0.0
has part: P19687
has part: CHEBI:16480
constant: false
in compartment: 481131
initial amount: NaN
has part: P16068
type: Species
has only substance units: false
is: SBO:0000297

389854
stoichiometry: 1.0
species: 481171
type: SpeciesReference

metaid_0000044
constant: true
units: metaid_0000035
value: 25.0
name: k10
type: Parameter

389673
exponent: 1.0
scale: -6
multipler: 1.0
kind: MOLE
type: SBMLUnit

metaid_0000049
kinetic law: 389915
product: 389903
reactant: 389891
is: SBO:0000181
fast: false
reversible: true
name: r3fast
type: Reaction

481351
type: Species
initial concentration: 0.288
boundary condition: false
has only substance units: false
is: SBO:0000297
constant: false
initial amount: NaN
has part: P19687
in compartment: 481131
has part: P16068

389866
stoichiometry: 1.0
species: 481191
type: SpeciesReference

390025
stoichiometry: 1.0
species: 481311
type: SpeciesReference

389891
stoichiometry: 1.0
species: 481191
type: SpeciesReference

metaid_0000040
constant: true
units: metaid_0000031
value: 700.0
name: k6
type: Parameter

389733
exponent: -1.0
scale: 0
multipler: 1.0
kind: LITRE
type: SBMLUnit

metaid_0500046
notes: extinction at 431 nm
constant: false
units: metaid_0010031
value: NaN
name: extinction
type: Parameter

metaid_0010046
constant: true
units: metaid_0000035
value: 0.02
name: k12
type: Parameter

389794
exponent: -1.0
scale: -2
multipler: 1.0
kind: METRE
type: SBMLUnit

482411
in compartment: 481131
has part: P19687
is: SBO:0000297
has part: P16068
boundary condition: false
has part: CHEBI:16480
initial amount: NaN
type: Species
has only substance units: false
constant: false
initial concentration: 0.0

481291
has part: P16068
constant: false
boundary condition: false
initial concentration: 0.0
has part: CHEBI:16480
has part: P19687
initial amount: NaN
has only substance units: false
type: Species
is: SBO:0000297
in compartment: 481131

metaid_0000036
constant: true
units: metaid_0000035
value: 800.0
name: k2
type: Parameter

389988
stoichiometry: 1.0
species: 481311
type: SpeciesReference

481391
has only substance units: false
constant: false
type: Species
initial concentration: 0.5
in compartment: 481131
is: CHEBI:16480
is: SBO:0000247
is: C00533
boundary condition: true
initial amount: NaN

metaid_0000053
kinetic law: 390085
product: 390073
reactant: 390061
is: SBO:0000181
fast: false
reversible: true
name: r4slow
type: Reaction

389818
stoichiometry: 1.0
species: 481211
type: SpeciesReference

390037
stoichiometry: 1.0
species: 481291
type: SpeciesReference

metaid_0000047
kinetic law: 389842
product: 389830
reactant: 389818
reactant: 389806
is: SBO:0000177
fast: false
reversible: true
name: r1fast
type: Reaction

481331
has part: P19687
has part: P16068
is: SBO:0000297
type: Species
in compartment: 481131
initial amount: NaN
boundary condition: false
has only substance units: false
initial concentration: 0.0
constant: false
has part: CHEBI:16480

389927
stoichiometry: 1.0
species: 481391
type: SpeciesReference

390012
stoichiometry: 1.0
species: 481391
type: SpeciesReference

389697
exponent: -1.0
scale: -6
multipler: 1.0
kind: MOLE
type: SBMLUnit

metaid_0000037
constant: true
units: metaid_0000035
value: 850.0
name: k3
type: Parameter

metaid_0000042
constant: true
units: metaid_0000035
value: 850.0
name: k8
type: Parameter

389770
exponent: -1.0
scale: -6
multipler: 1.0
kind: MOLE
type: SBMLUnit

481411
has part: CHEBI:16480
is: SBO:0000297
in compartment: 481131
has part: P19687
type: Species
initial concentration: 0.0
has only substance units: false
constant: false
boundary condition: false
initial amount: NaN
has part: P16068

481311
boundary condition: false
initial concentration: 0.0
has part: P19687
has part: P16068
constant: false
initial amount: NaN
has only substance units: false
is: SBO:0000297
type: Species
in compartment: 481131
has part: CHEBI:16480

metaid_0000052
kinetic law: 390049
product: 390037
reactant: 390025
reactant: 390012
is: SBO:0000177
fast: false
reversible: true
name: r3slow
type: Reaction

metaid_0000048
kinetic law: 389879
product: 389866
reactant: 389854
is: SBO:0000181
fast: false
reversible: false
name: r2fast
type: Reaction

389782
exponent: -1.0
scale: -2
multipler: 1.0
kind: METRE
type: SBMLUnit

389976
stoichiometry: 1.0
species: 481331
type: SpeciesReference

metaid_0000038
constant: true
units: metaid_0000035
value: 20.0
name: k4
type: Parameter

metaid_0000041
constant: true
units: metaid_0000035
value: 800.0
name: k7
type: Parameter

389746
exponent: -1.0
scale: 0
multipler: 1.0
kind: SECOND
type: SBMLUnit

389830
stoichiometry: 1.0
species: 481171
type: SpeciesReference

389806
stoichiometry: 1.0
species: 481391
type: SpeciesReference

metaid_0000051
kinetic law: 390000
product: 389988
reactant: 389976
is: SBO:0000181
fast: false
reversible: false
name: r2slow
type: Reaction

481131
is: GO:0005829
constant: true
size: 1.0
spatial dimensions: 3.0
type: Compartment