294677
is: SBO:0000247
in compartment: 394597
initial concentration: NaN
has only substance units: true
name: bound intracellular BSP
initial amount: 0.0
boundary condition: false
type: Species
constant: false
is: C11363

metaid_0000026
constant: true
units: metaid_0000042
value: 0.0827
type: Parameter

059526
exponent: 1.0
scale: 0
multipler: 60.0
kind: SECOND
type: SBMLUnit

059815
stoichiometry: 1.0
species: 294637
type: SpeciesReference

294757
kinetic law: 059695
product: 059683
reactant: 059671
is version of: GO:0006810
is: SBO:0000185
fast: false
reversible: false
name: endogenous basolateral import
type: Reaction

metaid_0000041
unit: 059526
name: min
type: SBMLUnitsDef

059587
exponent: -1.0
scale: 0
multipler: 60.0
kind: SECOND
type: SBMLUnit

metaid_0000032
constant: true
units: metaid_0000042
value: 1.6
type: Parameter

294897
kinetic law: 059948
product: 059936
reactant: 059924
is version of: GO:0006810
is: SBO:0000185
fast: false
reversible: true
name: paracellular transport
type: Reaction

059598
stoichiometry: 1.0
species: 294617
type: SpeciesReference

059791
stoichiometry: 1.0
species: 294637
type: SpeciesReference

294697
has only substance units: true
in compartment: 494597
is: C11363
constant: false
initial amount: 0.0
type: Species
initial concentration: NaN
name: apical BSP
boundary condition: false
is: SBO:0000247

059779
stoichiometry: 1.0
species: 294617
type: SpeciesReference

059899
stoichiometry: 1.0
species: 294657
type: SpeciesReference

metaid_0000029
constant: true
units: metaid_0000042
value: 0.0397
type: Parameter

294877
kinetic law: 059912
product: 059899
reactant: 059887
is: SBO:0000180
fast: false
reversible: false
name: cellular BSP dissoc
type: Reaction

294797
kinetic law: 059767
product: 059755
reactant: 059743
is version of: GO:0006810
is: SBO:0000185
fast: false
reversible: false
name: endogenous apical export
type: Reaction

294817
kinetic law: 059803
product: 059791
reactant: 059779
is version of: GO:0005488
is: SBO:0000177
fast: false
reversible: false
name: basolateral BSP binding
type: Reaction

metaid_0000039
unit: 059502
name: nmole
type: SBMLUnitsDef

059755
stoichiometry: 1.0
species: 294697
type: SpeciesReference

294617
name: free basolateral BSP
type: Species
initial amount: 88.0
initial concentration: NaN
is: C11363
boundary condition: false
constant: false
is: SBO:0000247
in compartment: 294597
has only substance units: true

metaid_0000042
unit: 059538
name: permin
type: SBMLUnitsDef

294777
kinetic law: 059731
product: 059719
reactant: 059707
is version of: GO:0006810
is: SBO:0000185
fast: false
reversible: false
name: endogenous basolateral export
type: Reaction

059574
exponent: -1.0
scale: -9
multipler: 1.0
kind: MOLE
type: SBMLUnit

059924
stoichiometry: 1.0
species: 294617
type: SpeciesReference

059647
stoichiometry: 1.0
species: 294697
type: SpeciesReference

metaid_0010024
constant: true
units: metaid_0000042
value: 0.0013
type: Parameter

059719
stoichiometry: 1.0
species: 294617
type: SpeciesReference

059502
exponent: 1.0
scale: -9
multipler: 1.0
kind: MOLE
type: SBMLUnit

294597
is: GO:0005615
is: SBO:0000290
constant: true
size: 1.0
spatial dimensions: 3.0
name: basolateral extrocellular space
type: Compartment

metaid_0000031
constant: true
units: metaid_0000044
value: 0.0098
type: Parameter

059550
exponent: 1.0
scale: -3
multipler: 1.0
kind: LITRE
type: SBMLUnit

294837
kinetic law: 059839
product: 059827
reactant: 059815
is: SBO:0000180
fast: false
reversible: false
name: basolateral BSP dissoc
type: Reaction

294857
kinetic law: 059875
product: 059863
reactant: 059851
is version of: GO:0005488
is: SBO:0000177
fast: false
reversible: false
name: cellular BSP binding
type: Reaction

059683
stoichiometry: 1.0
species: 294657
type: SpeciesReference

metaid_0000024
constant: true
units: metaid_0000042
value: 0.0784
type: Parameter

059827
stoichiometry: 1.0
species: 294617
type: SpeciesReference

059863
stoichiometry: 1.0
species: 294677
type: SpeciesReference

059514
exponent: 1.0
scale: -3
multipler: 1.0
kind: LITRE
type: SBMLUnit

294888
in compartment: 494597
is: SBO:0000247
is: C11363
boundary condition: true
initial amount: NaN
has only substance units: true
constant: false
initial concentration: NaN
name: total BSP
type: Species

059611
stoichiometry: 1.0
species: 294657
type: SpeciesReference

059887
stoichiometry: 1.0
species: 294677
type: SpeciesReference

metaid_0000034
constant: true
units: metaid_0000043
value: 3.0E-4
type: Parameter

metaid_0000044
unit: 059587
unit: 059574
name: per_nmole_per_ml
type: SBMLUnitsDef

metaid_0000028
constant: true
units: metaid_0000044
value: 6.4E-5
type: Parameter

059538
exponent: -1.0
scale: 0
multipler: 60.0
kind: SECOND
type: SBMLUnit

metaid_0000023
constant: true
units: metaid_0000042
value: 0.0025
type: Parameter

294717
kinetic law: 059622
product: 059611
reactant: 059598
is version of: GO:0006810
is: SBO:0000185
fast: false
reversible: false
name: OATP1B3 mediated import
type: Reaction

metaid_0000030
constant: true
units: metaid_0000039
value: 1000.0
type: Parameter

059707
stoichiometry: 1.0
species: 294657
type: SpeciesReference

059634
stoichiometry: 1.0
species: 294657
type: SpeciesReference

294637
name: basolateral bound BSP
initial amount: 0.0
is: C11363
has only substance units: true
boundary condition: false
in compartment: 294597
type: Species
initial concentration: NaN
is: SBO:0000247
constant: false

metaid_0000040
unit: 059514
name: ml
type: SBMLUnitsDef

294889
has only substance units: true
is: SBO:0000247
is: C11363
initial concentration: NaN
in compartment: 394597
name: intracellular BSP
boundary condition: true
initial amount: NaN
constant: false
type: Species

394597
is: GO:0005623
is: SBO:0000290
constant: true
size: 1.0
spatial dimensions: 3.0
name: intracellular
type: Compartment

294657
initial amount: 0.0
initial concentration: NaN
name: free intracellular BSP
is: SBO:0000247
constant: false
is: C11363
type: Species
in compartment: 394597
boundary condition: false
has only substance units: true

059851
stoichiometry: 1.0
species: 294657
type: SpeciesReference

BIOMD0000000197
rule: metaid_0000038
volume units: metaid_0000040
parameter: metaid_0000034
parameter: metaid_0000030
parameter: metaid_0000029
parameter: metaid_0000033
reaction: 294797
is described by: http://identifiers.org/pubmed/17548463
species: 294657
compartment: 394597
species: 294888
units def: metaid_0000040
creator:
  ORG:
    orgname: EMBL-EBI
  n:
    given: Lukas
    family: Endler
modified:
  W3 CDTF: Thu Jul 05 15:47:47 BST 2012
species: 294617
occurs in: http://identifiers.org/taxonomy/40674
notes: SBML model exported from PottersWheel on 2007-09-19 15:35:47. The values for parameters and the inital concentrations of this model where directly provided by the main author: Parameter values parameter value unit p1 0.0025 1/min p2 0.0784 1/min p3 0.0013 1/min p4 0.0827 1/min p5 0.0091 1/min p6 0.000064 1/(nmole*min) p7 0.0397 1/min p8 1000 nmole p9 0.0098 1/(nmole*min) p10 1.6 1/min p11 1000 nmole p12 0.0003 ml/min The basal chamber volume was taken as 1 ml, the apical as 1.5. As starting values x1 was set to 88 nmole, all other species to 0. To the extent possible under law, all copyright and related or neighbouring rights to this encoded model have been dedicated to the public domain worldwide. Please refer to CC0 Public Domain Dedication for more information. In summary, you are entitled to use this encoded model in absolutely any manner you deem suitable, verbatim, or with modification, alone or embedded it in a larger context, redistribute it, commercially or not, in a restricted way or not. To cite BioModels Database, please use: Li C, Donizelli M, Rodriguez N, Dharuri H, Endler L, Chelliah V, Li L, He E, Henry A, Stefan MI, Snoep JL, Hucka M, Le Novère N, Laibe C (2010) BioModels Database: An enhanced, curated and annotated resource for published quantitative kinetic models. BMC Syst Biol., 4:92.
reaction: 294757
species: 294697
parameter: metaid_0000024
type: SBMLModel
species: 294637
creator:
  ORG:
    orgname: Department for brain research, Anatomical Institute I, Hansastr. 9a, D-79104 Freiburg, Germany
  n:
    given: Kilian
    family: Bartholomé
parameter: metaid_0000032
parameter: metaid_0000031
substance units: metaid_0000039
species: 294889
units def: metaid_0000042
created:
  W3 CDTF: Thu Sep 25 17:51:05 BST 2008
species: 294677
reaction: 294777
compartment: 294597
parameter: metaid_0000028
reaction: 294817
reaction: 294837
units def: metaid_0000044
is version of: GO:0006810
rule: metaid_0000037
reaction: 294717
parameter: metaid_0000023
reaction: 294737
curated: true
parameter: metaid_0010024
units def: metaid_0000039
length unit: length
is: MODEL0212154960
reaction: 294897
units def: metaid_0000041
name: Bartholome2007_MDCKII
parameter: metaid_0000027
units def: metaid_0000043
reaction: 294857
reaction: 294877
area units: metaid_0000005
time units: metaid_0000041
compartment: 494597
parameter: metaid_0000026

metaid_0000033
constant: true
units: metaid_0000039
value: 1000.0
type: Parameter

059562
exponent: -1.0
scale: 0
multipler: 60.0
kind: SECOND
type: SBMLUnit

059671
stoichiometry: 1.0
species: 294617
type: SpeciesReference

059936
stoichiometry: 1.0
species: 294697
type: SpeciesReference

metaid_0000043
unit: 059562
unit: 059550
name: ml_per_min
type: SBMLUnitsDef

059743
stoichiometry: 1.0
species: 294657
type: SpeciesReference

494597
is: GO:0005615
is: SBO:0000290
constant: true
size: 1.5
spatial dimensions: 3.0
name: apical extracellular space
type: Compartment

294737
fast: false
name: ABCC2 mediated export
reversible: false
is: SBO:0000185
reactant: 059634
product: 059647
is version of: hsa02010
kinetic law: 059659
is version of: GO:0015415
type: Reaction

metaid_0000027
constant: true
units: metaid_0000042
value: 0.0091
type: Parameter