241032
stoichiometry: 1.0
species: metaid_0000048
type: SpeciesReference

metaid_0000019
constant: true
value: 0.5
name: k8
type: Parameter

240706
stoichiometry: 1.0
species: metaid_0000045
type: SpeciesReference

metaid_0000061
kinetic law: 240658
modifier: 240646
reactant: 240634
is version of: GO:0008054
is version of: REACT 6761.1
fast: false
reversible: false
name: CycBt degradation via Cdh1
type: Reaction

metaid_0000009
constant: true
value: 10.0
name: k3pp
type: Parameter

metaid_0000071
kinetic law: 241044
reactant: 241032
is version of: GO:0030163
fast: false
reversible: false
name: IEP degradation
type: Reaction

metaid_0000011
constant: true
value: 35.0
name: k4
type: Parameter

metaid_0000080
unit: 240562
name: normalized
type: SBMLUnitsDef

metaid_0000041
is version of: GO:0000307
initial amount: 0.001
has version: P24871
boundary condition: false
has version: P30283
has version: P32943
has version: P24868
type: Species
constant: false
initial concentration: NaN
has version: P24869
has only substance units: true
in compartment: metaid_0000040
has version: P24870
has version: P00546
has part: IPR015454
name: CycBt
has part: P00546

metaid_0000051
type: Species
has only substance units: true
constant: false
is version of: P20437
initial concentration: NaN
in compartment: metaid_0000040
name: SK
boundary condition: false
initial amount: 0.001
is version of: P20438
is version of: IPR014399

metaid_0000031
constant: true
value: 1.0
name: k14
type: Parameter

metaid_0000029
constant: true
value: 1000.0
name: Keq
type: Parameter

metaid_0000039
constant: true
value: 0.04
name: J4
type: Parameter

240960
stoichiometry: 1.0
species: metaid_0000043
type: SpeciesReference

241164
stoichiometry: 1.0
species: metaid_0000050
type: SpeciesReference

metaid_0000021
constant: true
value: 0.1
name: k9
type: Parameter

metaid_0000062
kinetic law: 240694
modifier: 240682
reactant: 240670
is version of: REACT 6820.1
fast: false
reversible: false
name: CycBt degradation via Cdc20a
type: Reaction

metaid_0000072
kinetic law: 241068
product: 241056
is version of: GO:0016049
fast: false
reversible: false
name: growth
type: Reaction

metaid_0000012
constant: true
value: 0.005
name: k5p
type: Parameter

metaid_0000059
kinetic law: 240598
product: 240586
is version of: GO:0010467
fast: false
reversible: false
name: CycBt synthesis
type: Reaction

241080
stoichiometry: 1.0
species: metaid_0000050
type: SpeciesReference

metaid_0000032
constant: true
value: 1.5
name: k15p
type: Parameter

metaid_0000042
name: CycB
has part: IPR015454
type: Species
constant: false
has part: P00546
in compartment: metaid_0000040
initial amount: NaN
boundary condition: false
initial concentration: NaN
has only substance units: true

metaid_0000079
event assignment: 241285
delay: 241273
trigger: 241261
is: GO:0000910
use values from trigger time: true
name: Cell division
type: Event

metaid_0000069
kinetic law: 240972
reactant: 240960
is version of: GO:0030163
fast: false
reversible: false
name: Cdc20a degradation
type: Reaction

BIOMD0000000195
is version of: map04111
parameter: metaid_0000022
species: metaid_0000049
reaction: metaid_0000061
is described by: http://identifiers.org/pubmed/11371178
parameter: metaid_0000019
parameter: metaid_0000028
species: metaid_0000051
species: metaid_0000042
notes: This model describes the budding yeast cell cycle model used in fig 8 a in Regulation of the eukaryotic cell cycle: molecular antagonism, hysteresis, and irreversible transitions. Tyson JJ and Novak B., J Theor Biol 2001 May;210(2):249-63. It consitsts of the equations (2)-(8), with mu=0.005 min -1 . It was taken from Cell Cycle DB ( file ) and only slightly altered. To the extent possible under law, all copyright and related or neighbouring rights to this encoded model have been dedicated to the public domain worldwide. Please refer to CC0 Public Domain Dedication for more information. In summary, you are entitled to use this encoded model in absolutely any manner you deem suitable, verbatim, or with modification, alone or embedded it in a larger context, redistribute it, commercially or not, in a restricted way or not. To cite BioModels Database, please use: Li C, Donizelli M, Rodriguez N, Dharuri H, Endler L, Chelliah V, Li L, He E, Henry A, Stefan MI, Snoep JL, Hucka M, Le Novère N, Laibe C (2010) BioModels Database: An enhanced, curated and annotated resource for published quantitative kinetic models. BMC Syst Biol., 4:92.
parameter: metaid_0000036
parameter: metaid_0000029
parameter: metaid_0000035
parameter: metaid_0000038
reaction: metaid_0000064
units def: metaid_0000080
parameter: metaid_0000005
parameter: metaid_0000012
parameter: metaid_0000026
reaction: metaid_0000072
reaction: metaid_0000071
reaction: metaid_0000065
species: metaid_0000047
reaction: metaid_0000074
name: Goldbeter Koshland Function
species: metaid_0000050
parameter: metaid_0000033
reaction: metaid_0000062
rule: metaid_0000056
function def: metaid_0000003
occurs in: http://identifiers.org/taxonomy/4932
time units: metaid_0000081
parameter: metaid_0000039
is version of: REACT 152.2
parameter: metaid_0000010
parameter: metaid_0000007
parameter: metaid_0000016
parameter: metaid_0000009
species: metaid_0000041
reaction: metaid_0000076
reaction: metaid_0000067
reaction: metaid_0000075
parameter: metaid_0000052
reaction: metaid_0000078
length unit: length
species: metaid_0000044
event: metaid_0000079
species: metaid_0000046
compartment: metaid_0000040
parameter: metaid_0000004
parameter: metaid_0000006
parameter: metaid_0000023
parameter: metaid_0000037
reaction: metaid_0000066
volume units: metaid_0000004
rule: metaid_0000054
curated: true
name: Tyson2001_Cell_Cycle_Regulation
parameter: metaid_0000011
type: SBMLModel
parameter: metaid_0000014
parameter: metaid_0000020
parameter: metaid_0000013
rule: metaid_0000058
reaction: metaid_0000073
reaction: metaid_0000070
substance units: metaid_0000080
parameter: metaid_0000021
parameter: metaid_0000008
reaction: metaid_0000059
parameter: metaid_0000027
reaction: metaid_0000068
area units: metaid_0000005
species: metaid_0000043
parameter: metaid_0000015
is: MODEL3897475441
parameter: metaid_0000018
parameter: metaid_0000024
parameter: metaid_0000017
reaction: metaid_0000077

240574
exponent: 1.0
scale: 0
multipler: 60.0
kind: SECOND
type: SBMLUnit

metaid_0000052
constant: false
value: NaN
name: TF
type: Parameter

metaid_0000049
is version of: P40957
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: NaN
in compartment: metaid_0000040
name: Mad
type: Species

metaid_0000022
constant: true
value: 0.02
name: k10
type: Parameter

240610
stoichiometry: 1.0
species: metaid_0000041
type: SpeciesReference

metaid_0000048
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.001
in compartment: metaid_0000040
name: IEP
type: Species

metaid_0000013
constant: true
value: 0.2
name: k5pp
type: Parameter

metaid_0000007
constant: true
value: 1.0
name: k2ppp
type: Parameter

240802
stoichiometry: 1.0
species: metaid_0000047
type: SpeciesReference

metaid_0000073
kinetic law: 241092
product: 241080
is version of: GO:0010467
fast: false
reversible: false
name: CKIt synthesis
type: Reaction

metaid_0000027
constant: true
value: 10.0
name: mmax
type: Parameter

metaid_0000033
constant: true
value: 0.05
name: k15pp
type: Parameter

240876
stoichiometry: 1.0
species: metaid_0000043
type: SpeciesReference

metaid_0000068
kinetic law: 240948
modifier: 240936
reactant: 240924
is version of: REACT 1041.2
fast: false
reversible: false
name: Cdc20a inhibition
type: Reaction

metaid_0000060
kinetic law: 240622
reactant: 240610
is version of: GO:0008054
fast: false
reversible: false
name: CycBt degradation
type: Reaction

metaid_0000074
kinetic law: 241116
reactant: 241104
is version of: GO:0030163
fast: false
reversible: false
name: CKIt degradation
type: Reaction

metaid_0000047
is version of: P26309
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.001
in compartment: metaid_0000040
name: Cdc20t
type: Species

metaid_0000008
constant: true
value: 1.0
name: k3p
type: Parameter

240742
stoichiometry: 1.0
species: metaid_0000045
type: SpeciesReference

metaid_0000014
constant: true
value: 0.3
name: J5
type: Parameter

metaid_0000081
unit: 240574
name: minutes
type: SBMLUnitsDef

metaid_0000034
constant: true
value: 1.0
name: k16p
type: Parameter

metaid_0000028
constant: true
value: 100.0
name: k12ppp
type: Parameter

240924
stoichiometry: 1.0
species: metaid_0000043
type: SpeciesReference

metaid_0000020
constant: true
value: 0.001
name: J8
type: Parameter

metaid_0000040
is: GO:0005623
constant: true
size: 1.0
spatial dimensions: 3.0
name: cell
type: Compartment

240586
stoichiometry: 1.0
species: metaid_0000041
type: SpeciesReference

241213
stoichiometry: 1.0
species: metaid_0000051
type: SpeciesReference

metaid_0000067
kinetic law: 240912
modifier: 240900
modifier: 240888
product: 240876
is version of: REACT 6954.1
fast: false
reversible: false
name: Cdc20 activation
type: Reaction

metaid_0000065
kinetic law: 240838
modifier: 240826
modifier: 240814
product: 240802
is version of: GO:0010467
fast: false
reversible: false
name: Cdc20t synthesis
type: Reaction

240670
stoichiometry: 1.0
species: metaid_0000041
type: SpeciesReference

metaid_0000005
constant: true
value: 0.04
name: k2p
type: Parameter

metaid_0000046
is version of: GO:0016049
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.5
in compartment: metaid_0000040
name: m
type: Species

metaid_0000075
kinetic law: 241152
modifier: 241140
reactant: 241128
is version of: REACT 9003.1
fast: false
reversible: false
name: CKIt phosphorilation via SK
type: Reaction

metaid_0000025
constant: true
value: 0.2
name: k12p
type: Parameter

241056
stoichiometry: 1.0
species: metaid_0000046
type: SpeciesReference

metaid_0000015
constant: true
value: 0.1
name: k6
type: Parameter

metaid_0000035
constant: true
value: 3.0
name: k16pp
type: Parameter

241128
stoichiometry: 1.0
species: metaid_0000050
type: SpeciesReference

metaid_0000066
kinetic law: 240863
reactant: 240851
is version of: GO:0030163
fast: false
reversible: false
name: Cdc20t degradation
type: Reaction

metaid_0000006
constant: true
value: 1.0
name: k2pp
type: Parameter

metaid_0000016
constant: true
value: 4.0
name: n
type: Parameter

metaid_0000045
is version of: P53197
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.001
in compartment: metaid_0000040
name: Cdh1
type: Species

metaid_0000076
name: CKIt Trimer sequestred
reactant: 241164
is version of: REACT 9005.1
kinetic law: 241201
modifier: 241177
modifier: 241189
fast: false
is version of: GO:0045736
type: Reaction
reversible: false

metaid_0000026
constant: true
value: 50.0
name: k12pp
type: Parameter

metaid_0000036
constant: true
value: 0.01
name: J15
type: Parameter

metaid_0000063
kinetic law: 240730
modifier: 240718
product: 240706
is version of: GO:0010467
fast: false
reversible: false
name: Cdh1 synthesis
type: Reaction

240562
exponent: 1.0
scale: 0
multipler: 1.0
kind: DIMENSIONLESS
type: SBMLUnit

metaid_0000044
initial concentration: NaN
has part: P38634
boundary condition: false
name: Trimer
in compartment: metaid_0000040
type: Species
constant: false
has part: IPR015454
has only substance units: true
has part: P00546
initial amount: NaN

metaid_0000030
constant: true
value: 1.0
name: k13
type: Parameter

metaid_0000077
kinetic law: 241225
product: 241213
is version of: GO:0010467
fast: false
reversible: false
name: SK synthesis
type: Reaction

metaid_0000017
constant: true
value: 1.0
name: k7
type: Parameter

241104
stoichiometry: 1.0
species: metaid_0000050
type: SpeciesReference

metaid_0000023
constant: true
value: 0.005
name: mu
type: Parameter

metaid_0000037
constant: true
value: 0.01
name: J16
type: Parameter

240851
stoichiometry: 1.0
species: metaid_0000047
type: SpeciesReference

metaid_0000038
constant: true
value: 2.0
name: k4p
type: Parameter

metaid_0000010
constant: true
value: 0.04
name: J3
type: Parameter

metaid_0000064
fast: false
type: Reaction
modifier: 240778
reactant: 240742
kinetic law: 240790
reversible: false
is version of: GO:0030163
modifier: 240766
modifier: 240754
name: Cdh1 degradation

241237
stoichiometry: 1.0
species: metaid_0000051
type: SpeciesReference

241261
persistant: true
initial value: true
type: Trigger

metaid_0000043
is version of: P26309
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.001
in compartment: metaid_0000040
name: Cdc20a
type: Species

240984
stoichiometry: 1.0
species: metaid_0000048
type: SpeciesReference

metaid_0000018
constant: true
value: 0.001
name: J7
type: Parameter

metaid_0000078
kinetic law: 241249
reactant: 241237
is version of: GO:0008054
is version of: GO:0030163
fast: false
reversible: false
name: SK degradation
type: Reaction

metaid_0000070
kinetic law: 241020
modifier: 241008
modifier: 240996
product: 240984
is version of: GO:0010467
fast: false
reversible: false
name: IEP synthesis
type: Reaction

metaid_0000024
constant: true
value: 1.0
name: k11
type: Parameter

240634
stoichiometry: 1.0
species: metaid_0000041
type: SpeciesReference

metaid_0000004
constant: true
value: 0.04
name: k1
type: Parameter

metaid_0000050
is version of: P38634
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.001
in compartment: metaid_0000040
name: CKIt
type: Species

orgname: EMBL-EBI

W3 CDTF: Thu Feb 26 10:08:01 GMT 2009

W3 CDTF: Thu Jul 05 15:50:51 BST 2012

n:
  given: Lukas
  family: Endler