334116
stoichiometry: 1.0
species: metaid_0000019
type: SpeciesReference

metaid_0000025
kinetic law: 334153
product: 334141
product: 334128
reactant: 334116
is version of: GO:0043241
fast: false
reversible: false
type: Reaction

metaid_0000019
name: Cdc20:C-Mad2
type: Species
initial concentration: 0.0
substance units: mole
is: SBO:0000297
constant: false
has only substance units: false
in compartment: metaid_0000014
initial amount: NaN
has part: Q12834
has part: Q13257
boundary condition: false

metaid_0000015
has part: Q13257
boundary condition: false
name: Mad1:C-Mad2
has part: Q9Y6D9
substance units: mole
type: Species
initial amount: NaN
initial concentration: 5.0E-8
constant: false
is: SBO:0000297
in compartment: metaid_0000014
has only substance units: false

334092
stoichiometry: 1.0
species: metaid_0000019
type: SpeciesReference

metaid_0000009
is: SBO:0000339
constant: true
units: metaid_0000043
value: 200000.0
type: Parameter

333982
exponent: -1.0
scale: 0
multipler: 1.0
kind: MOLE
type: SBMLUnit

333994
exponent: -1.0
scale: 0
multipler: 1.0
kind: SECOND
type: SBMLUnit

334067
stoichiometry: 1.0
species: metaid_0000018
type: SpeciesReference

metaid_0000016
name: O-Mad2
in compartment: metaid_0000014
boundary condition: false
initial concentration: 1.5E-7
constant: false
notes: Open conformation of Mad2
has only substance units: false
is version of: Q13257
substance units: mole
type: Species
initial amount: NaN

333958
exponent: -1.0
scale: 0
multipler: 1.0
kind: SECOND
type: SBMLUnit

334018
stoichiometry: 1.0
species: metaid_0000016
type: SpeciesReference

metaid_0000031
event assignment: 334177
trigger: 334165
is: GO:0008608
use values from trigger time: true
name: Microtubule attachment
type: Event

334080
stoichiometry: 1.0
species: metaid_0000015
type: SpeciesReference

metaid_0000045
constant: true
units: dimensionless
value: 1.0
type: Parameter

BIOMD0000000194
compartment: metaid_0000014
is version of: REACT 2137.2
creator:
  ORG:
    orgname: Friedrich-Schiller-University Jena, Germany
  n:
    given: Peter
    family: Dittrich
units def: metaid_0000042
units def: metaid_0000043
is part of: hsa04110
species: metaid_0000016
notes: Biophysical Chemistry 134 (2008) 93-100 Mad2 binding is not sufficient for complete Cdc20 sequestering in mitotic transition control (an in silico study) Bashar Ibrahim, Peter Dittrich, Stephan Diekmann, Eberhard Schmitt This model originates from BioModels Database: A Database of Annotated Published Models. It is copyright (c) 2005-2009 The BioModels Team. For more information see the terms of use . To cite BioModels Database, please use Le Novère N., Bornstein B., Broicher A., Courtot M., Donizelli M., Dharuri H., Li L., Sauro H., Schilstra M., Shapiro B., Snoep J.L., Hucka M. (2006) BioModels Database: A Free, Centralized Database of Curated, Published, Quantitative Kinetic Models of Biochemical and Cellular Systems Nucleic Acids Res., 34: D689-D691.
volume units: metaid_0000004
area units: metaid_0000005
created:
  W3 CDTF: Thu Sep 11 21:58:11 BST 2008
parameter: metaid_0000008
reaction: metaid_0000023
parameter: metaid_0000044
substance units: metaid_0000040
reaction: metaid_0000024
species: metaid_0000018
species: metaid_0000015
event: metaid_0000031
type: SBMLModel
curated: true
creator:
  ORG:
    orgname: Fritz Lipmann Institute, Jena, Germany
  n:
    given: Stephan
    family: Diekmann
creator:
  ORG:
    orgname: EMBL-EBI
  n:
    given: Lukas
    family: Endler
time units: metaid_0000008
is: MODEL1667525941
parameter: metaid_0000009
modified:
  W3 CDTF: Wed Sep 23 18:09:50 BST 2009
parameter: metaid_0000045
reaction: metaid_0000025
creator:
  ORG:
    orgname: Fritz Lipmann Institute, Jena, Germany
  n:
    given: Eberhard
    family: Schmitt
parameter: metaid_0000007
occurs in: http://identifiers.org/taxonomy/9606
parameter: metaid_0000003
species: metaid_0000017
creator:
  ORG:
    orgname: German Cancer Research Center, Heidelberg
  n:
    given: Bashar
    family: Ibrahim
is version of: GO:0007094
is described by: http://identifiers.org/pubmed/18295960
species: metaid_0000019
parameter: metaid_0000010
length unit: length
name: Ibrahim2008_Cdc20_Sequestring_Template_Model

334165
persistant: true
initial value: true
type: Trigger

metaid_0000023
is version of: GO:0006461
reversible: true
is version of: GO:0032092
product: 334030
reactant: 334006
type: Reaction
fast: false
reactant: 334018
is version of: GO:0043241
kinetic law: 334042

334128
stoichiometry: 1.0
species: metaid_0000018
type: SpeciesReference

metaid_0000003
is: SBO:0000338
constant: true
units: metaid_0000042
value: 0.01
type: Parameter

metaid_0000017
has only substance units: false
initial amount: NaN
has part: Q13257
boundary condition: false
initial concentration: 0.0
type: Species
substance units: mole
has part: Q9Y6D9
constant: false
is: SBO:0000297
in compartment: metaid_0000014
name: Mad1:C-Mad2:O-Mad2*

333970
exponent: 1.0
scale: 0
multipler: 1.0
kind: LITRE
type: SBMLUnit

334141
stoichiometry: 1.0
species: metaid_0000016
type: SpeciesReference

metaid_0000007
notes: u = 1 : kinetochore unattached u = 0 : kinetochore attached
constant: false
units: dimensionless
value: 1.0
type: Parameter

metaid_0000044
constant: true
units: dimensionless
value: 0.0
type: Parameter

metaid_0000010
is: SBO:0000338
constant: true
units: metaid_0000042
value: 0.2
type: Parameter

metaid_0000024
reactant: 334067
is version of: GO:0006461
product: 334092
reversible: false
reactant: 334055
kinetic law: 334104
is version of: GO:0032092
fast: false
product: 334080
type: Reaction

334006
stoichiometry: 1.0
species: metaid_0000015
type: SpeciesReference

metaid_0000042
unit: 333958
name: per second
type: SBMLUnitsDef

334030
stoichiometry: 1.0
species: metaid_0000017
type: SpeciesReference

metaid_0000014
is: GO:0005737
constant: true
size: 1.0
spatial dimensions: 3.0
name: Cytoplasm
type: Compartment

metaid_0000018
in compartment: metaid_0000014
constant: false
boundary condition: false
initial concentration: 2.2E-7
name: Cdc20
has only substance units: false
is version of: Q12834
initial amount: NaN
type: Species
substance units: mole

metaid_0000043
unit: 333994
unit: 333982
unit: 333970
name: liter per mole per second
type: SBMLUnitsDef

334055
stoichiometry: 1.0
species: metaid_0000017
type: SpeciesReference

metaid_0000008
is: SBO:0000036
constant: true
units: metaid_0000043
value: 1.0E9
type: Parameter