metaid_0000017
modifier: 397101
fast: false
modifier: 397114
type: Reaction
is: GO:0015326
reversible: false
is: SBO:0000185
reactant: 397088
name: Ornithine efflux
kinetic law: 397126

396852
exponent: 1.0
scale: -6
multipler: 1.0
kind: MOLE
type: SBMLUnit

397062
is: SBO:0000324
units: metaid_0000021
value: 420.0
type: LocalParameter

397242
is: SBO:0000324
units: metaid_0000021
value: 1.33
type: LocalParameter

396816
exponent: 1.0
scale: -6
multipler: 1.0
kind: MOLE
type: SBMLUnit

metaid_0000013
in compartment: metaid_0000011
initial amount: NaN
name: Ornithine
boundary condition: false
is: C00077
initial concentration: 1.0
type: Species
is: CHEBI:15729
constant: false
has only substance units: false
is: SBO:0000247

396876
exponent: -1.0
scale: 0
multipler: 60.0
kind: SECOND
type: SBMLUnit

metaid_0000020
unit: 396840
unit: 396828
name: microM
type: SBMLUnitsDef

396950
is: SBO:0000322
units: metaid_0000020
value: 1500.0
type: LocalParameter

397293
is: SBO:0000324
units: metaid_0000021
value: 0.013
type: LocalParameter

metaid_0000010
is: GO:0005615
is: SBO:0000290
constant: true
size: 1.0
spatial dimensions: 3.0
name: extracellular
type: Compartment

397190
is: SBO:0000322
units: metaid_0000020
value: 847.0
type: LocalParameter

BIOMD0000000191
reaction: metaid_0000015
units def: metaid_0000008
modified:
  W3 CDTF: Thu Jul 05 17:50:05 BST 2012
reaction: metaid_0000017
is described by: http://identifiers.org/pubmed/17520329
creator:
  ORG:
    orgname: University of Malaga
  n:
    given: Raul
    family: Montañez
is part of: GO:0006527
occurs in: http://identifiers.org/taxonomy/40674
name: Montañez2008_Arginine_catabolism
units def: metaid_0000009
creator:
  ORG:
    orgname: Universitat Pompeu Fabra
  n:
    given: Carlos
    family: Rodríguez-Caso
has version: GO:0006591
reaction: metaid_0000019
species: metaid_0000013
creator:
  ORG:
    orgname: University of Malaga
  n:
    given: Francisca
    family: Sánchez-Jiménez
is part of: map00330
substance units: metaid_0000009
species: metaid_0000012
area units: metaid_0000005
units def: metaid_0000021
units def: metaid_0000020
length unit: length
reaction: metaid_0000016
creator:
  ORG:
    orgname: University of M?laga. CIBERER (Enfermedades Raras)
  n:
    given: Armando
    family: Reyes-Palomares
curated: true
has version: GO:0006809
type: SBMLModel
compartment: metaid_0000011
compartment: metaid_0000010
created:
  W3 CDTF: Thu Nov 27 11:36:17 GMT 2008
notes: SBML creators: Armando Reyes-Palomares * , Raul Montañez *, Carlos Rodriguez-Caso +, Francisca Sanchez-Jimenez * , Miguel A. Medina * * ProCel Group, Department of Molecular Biology and Biochemistry, Faculty of Sciences, Campus de Teatinos, University of Malaga and CIBER de Enfermedades Raras (CIBER-ER). + Complex Systems Lab (ICREA-UPF), Barcelona Biomedical Research Park (PRBB-GRIB). http://asp.uma.es In silico analysis of arginine catabolism as a source of nitric oxide or polyamines in endothelial cells. Montañez, R et al.: Amino Acids. 2008 Feb;34(2):223-9. The model reproduces the dynamical behavior of the arginine catabolism and transport in relation to the nitric oxide production. In this model there are some additions and corrections to the publication. All perturbations and analysis have produced results very close to the published experiments. The model was successfully tested on CoPaSi v.4.4 (build 26). Erratum: parameters values modificated respect to the publication to reach the steady-state: Kmodc=90 µM (60 µM in the paper) Kiornhat (is equivalent to the parameter Kmefflhat Eq ) = 360 µM (380 µM in the paper) To the extent possible under law, all copyright and related or neighbouring rights to this encoded model have been dedicated to the public domain worldwide. Please refer to CC0 Public Domain Dedication for more information. In summary, you are entitled to use this encoded model in absolutely any manner you deem suitable, verbatim, or with modification, alone or embedded it in a larger context, redistribute it, commercially or not, in a restricted way or not. To cite BioModels Database, please use: Li C, Donizelli M, Rodriguez N, Dharuri H, Endler L, Chelliah V, Li L, He E, Henry A, Stefan MI, Snoep JL, Hucka M, Le Novère N, Laibe C (2010) BioModels Database: An enhanced, curated and annotated resource for published quantitative kinetic models. BMC Syst Biol., 4:92.
species: metaid_0000014
creator:
  ORG:
    orgname: EMBL-EBI
  n:
    given: Lukas
    family: Endler
is: MODEL7416883636
reaction: metaid_0000018
creator:
  ORG:
    orgname: University of Malaga
  n:
    given: Miguel A.
    family: Medina
volume units: metaid_0000004
time units: metaid_0000008

397164
is: SBO:0000324
units: metaid_0000021
value: 160.5
type: LocalParameter

metaid_0000018
is version of: http://identifiers.org/ec-code/1.14.13.39
reactant: 397216
name: Nitric oxide synthase
is version of: REACT 12443.1
reversible: false
type: Reaction
is version of: R00557
kinetic law: 397229
is: SBO:0000211
fast: false
is version of: GO:0004517

metaid_0000014
constant: false
in compartment: metaid_0000011
is: SBO:0000247
has only substance units: false
initial amount: NaN
name: Arginine in
is: CHEBI:16467
boundary condition: false
initial concentration: 1.0
type: Species
is: C00062

397305
is: SBO:0000322
units: metaid_0000020
value: 90.0
type: LocalParameter

396901
stoichiometry: 1.0
species: metaid_0000013
type: SpeciesReference

397088
is: SBO:0000015
stoichiometry: 1.0
species: metaid_0000013
type: SpeciesReference

397025
is: SBO:0000322
units: metaid_0000020
value: 70.0
type: LocalParameter

397151
is: SBO:0000261
units: metaid_0000020
value: 847.0
type: LocalParameter

397050
is: SBO:0000322
units: metaid_0000020
value: 847.0
type: LocalParameter

396840
exponent: -1.0
scale: 0
multipler: 1.0
kind: LITRE
type: SBMLUnit

397255
units: metaid_0000020
value: 16.0
type: LocalParameter

metaid_0000019
is version of: R00670
fast: false
reactant: 397268
is version of: REACT 1211.3
is version of: GO:0004586
kinetic law: 397280
name: Ornithine decarboxylase
type: Reaction
reversible: false
is: SBO:0000211
is version of: http://identifiers.org/ec-code/4.1.1.17

396804
exponent: 1.0
scale: 0
multipler: 60.0
kind: SECOND
type: SBMLUnit

metaid_0000015
name: Arginase
is version of: GO:0004053
is version of: R00551
is version of: http://identifiers.org/ec-code/3.5.3.1
modifier: 396914
is version of: REACT 394.2
product: 396901
type: Reaction
kinetic law: 396926
reactant: 396889
fast: false
is: SBO:0000211
reversible: false

metaid_0000011
is: GO:0005829
is: SBO:0000290
constant: true
size: 1.0
spatial dimensions: 3.0
name: cytosol
type: Compartment

396889
stoichiometry: 1.0
species: metaid_0000014
type: SpeciesReference

397177
is: SBO:0000324
units: metaid_0000021
value: 420.0
type: LocalParameter

396864
exponent: -1.0
scale: 0
multipler: 1.0
kind: LITRE
type: SBMLUnit

396962
is: SBO:0000261
units: metaid_0000020
value: 1000.0
type: LocalParameter

397075
is: SBO:0000261
units: metaid_0000020
value: 360.0
type: LocalParameter

397216
is: SBO:0000015
stoichiometry: 1.0
species: metaid_0000014
type: SpeciesReference

396987
is: SBO:0000011
stoichiometry: 1.0
species: metaid_0000014
type: SpeciesReference

396828
exponent: 1.0
scale: -6
multipler: 1.0
kind: MOLE
type: SBMLUnit

396938
is: SBO:0000324
units: metaid_0000021
value: 110.0
type: LocalParameter

397139
is: SBO:0000261
units: metaid_0000020
value: 70.0
type: LocalParameter

396974
is: SBO:0000015
stoichiometry: 1.0
species: metaid_0000012
type: SpeciesReference

metaid_0000016
reactant: 396974
product: 396987
is: GO:0015326
reversible: false
modifier: 397000
is: SBO:0000185
name: Arginine transport
type: Reaction
kinetic law: 397012
fast: false

metaid_0000012
is: C00062
has only substance units: false
initial concentration: 330.0
constant: true
is: SBO:0000247
in compartment: metaid_0000010
boundary condition: true
initial amount: NaN
is: CHEBI:16467
type: Species
name: Arginine ex

397268
is: SBO:0000015
stoichiometry: 1.0
species: metaid_0000013
type: SpeciesReference

397037
is: SBO:0000324
units: metaid_0000020
value: 160.5
type: LocalParameter

metaid_0000021
unit: 396876
unit: 396864
unit: 396852
name: microMpermin
type: SBMLUnitsDef

397203
is: SBO:0000261
units: metaid_0000020
value: 360.0
type: LocalParameter