772069
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species: metaid_0000018
type: SpeciesReference

771997
stoichiometry: 1.0
species: metaid_0000323
type: SpeciesReference

metaid_0000045
constant: true
units: dimensionless
value: 1.0
type: Parameter

metaid_0000225
is version of: GO:0043623
reactant: 772057
reversible: true
reactant: 772069
kinetic law: 772093
type: Reaction
fast: false
product: 772081
is version of: GO:0007092

771721
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species: metaid_0000015
type: SpeciesReference

metaid_0000025
kinetic law: 771793
product: 771781
product: 771769
reactant: 771757
is version of: GO:0043241
fast: false
reversible: false
type: Reaction

771697
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species: metaid_0000017
type: SpeciesReference

metaid_1000007
notes: u = 0 : kinetochore unattached u = 1 : kinetochore attached
constant: false
units: dimensionless
value: 0.0
type: Parameter

771637
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scale: 0
multipler: 1.0
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type: SBMLUnit

metaid_0000006
constant: true
units: metaid_0000042
value: 0.2
type: Parameter

metaid_0000015
name: Mad1:C-Mad2
is version of: GO:0043234
initial concentration: 5.0E-8
boundary condition: false
in compartment: metaid_0000014
type: Species
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substance units: mole
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has part: Q9Y6D9

771865
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species: metaid_0000018
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species: metaid_0000020
type: SpeciesReference

772081
stoichiometry: 1.0
species: metaid_0000324
type: SpeciesReference

772009
stoichiometry: 1.0
species: metaid_0000016
type: SpeciesReference

metaid_0000812
constant: true
units: metaid_0000042
value: 0.08
type: Parameter

771661
stoichiometry: 1.0
species: metaid_0000016
type: SpeciesReference

metaid_0000224
reactant: 771997
is version of: GO:0007092
fast: false
is version of: GO:0043624
type: Reaction
product: 772009
product: 772021
product: 772033
kinetic law: 772045
reversible: false

metaid_0000044
constant: true
units: dimensionless
value: 0.0
type: Parameter

771925
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species: metaid_0000019
type: SpeciesReference

771591
exponent: -1.0
scale: 0
multipler: 1.0
kind: SECOND
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metaid_0000024
reversible: false
kinetic law: 771745
product: 771721
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fast: false
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reactant: 771709
is version of: GO:0032092
product: 771733

771769
stoichiometry: 1.0
species: metaid_0000018
type: SpeciesReference

metaid_0000014
is: GO:0005737
constant: true
size: 1.0
spatial dimensions: 3.0
name: Cytoplasm
type: Compartment

metaid_0000007
notes: u = 1 : kinetochore unattached u = 0 : kinetochore attached
constant: false
units: dimensionless
value: 1.0
type: Parameter

771709
stoichiometry: 1.0
species: metaid_0000018
type: SpeciesReference

771649
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species: metaid_0000015
type: SpeciesReference

metaid_0000223
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product: 771973
is version of: GO:0051436
is version of: GO:0043623
kinetic law: 771985
type: Reaction
reversible: false
reactant: 771961

771805
stoichiometry: 1.0
species: metaid_0000019
type: SpeciesReference

metaid_0000027
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type: Reaction
fast: false
kinetic law: 771889
reversible: true
product: 771877
reactant: 771853
reactant: 771865
is version of: GO:0043241

metaid_0000004
constant: true
units: metaid_0000043
value: 1000.0
type: Parameter

771733
stoichiometry: 1.0
species: metaid_0000019
type: SpeciesReference

metaid_0000322
has part: Q9UM13
has part: P30260
has part: Q9UJX3
is version of: GO:0005680
has part: Q9UJX6
name: APC
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initial concentration: 9.0E-8
has only substance units: false
initial amount: NaN
has part: Q9BS18
has part: Q9UJX2
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substance units: mole
constant: false
type: Species
has part: Q13042

771673
stoichiometry: 1.0
species: metaid_0000017
type: SpeciesReference

metaid_0000712
constant: true
units: metaid_0000043
value: 5000000.0
type: Parameter

metaid_0000031
event assignment: 772129
event assignment: 772117
trigger: 772105
use values from trigger time: true
name: Microtubule attachment
type: Event

772033
stoichiometry: 1.0
species: metaid_0000324
type: SpeciesReference

771853
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species: metaid_0000020
type: SpeciesReference

metaid_0000026
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is version of: GO:0043241
type: Reaction
reactant: 771805
kinetic law: 771841
product: 771829
is version of: GO:0006461
reversible: true
is version of: REACT 36.2
fast: false

metaid_0000005
constant: true
units: metaid_0000043
value: 10000.0
type: Parameter

metaid_0000012
constant: true
units: metaid_0000042
value: 0.02
type: Parameter

771949
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species: metaid_0000021
type: SpeciesReference

metaid_0000021
type: Species
has part: O43684
has part: Q60566
substance units: mole
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is: GO:0033597
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metaid_0000042
unit: 771591
name: per second
type: SBMLUnitsDef

metaid_0000011
constant: true
units: metaid_0000043
value: 1.0E7
type: Parameter

metaid_0000324
has part: Q9UJX3
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type: Species
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in compartment: metaid_0000014
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boundary condition: false
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initial concentration: 0.0
name: APC:Cdc20
has part: Q9H1A4
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metaid_0000019
initial concentration: 0.0
has part: Q13257
type: Species
constant: false
has only substance units: false
name: Cdc20:C-Mad2
boundary condition: false
in compartment: metaid_0000014
substance units: mole
initial amount: NaN
has part: Q12834

metaid_0000003
constant: true
units: metaid_0000042
value: 0.01
type: Parameter

metaid_0000018
initial concentration: 2.2E-7
boundary condition: false
name: Cdc20
is: Q12834
type: Species
has only substance units: false
initial amount: NaN
substance units: mole
in compartment: metaid_0000014
constant: false

771817
stoichiometry: 1.0
species: metaid_0000020
type: SpeciesReference

metaid_0000028
kinetic law: 771937
product: 771925
reactant: 771913
reactant: 771901
is version of: GO:0006461
fast: false
reversible: false
type: Reaction

772105
persistant: true
initial value: true
type: Trigger

771613
exponent: 1.0
scale: 0
multipler: 1.0
kind: LITRE
type: SBMLUnit

metaid_0000020
name: Bub3:BubR1
type: Species
has part: Q60566
substance units: mole
initial concentration: 1.27E-7
has only substance units: false
initial amount: NaN
boundary condition: false
in compartment: metaid_0000014
constant: false
has part: O43684

metaid_0000043
unit: 771637
unit: 771625
unit: 771613
name: liter per mole per second
type: SBMLUnitsDef

metaid_0000323
has part: Q9BS18
has part: GO:0033597
has part: Q9UJX2
has part: Q9UJX5
name: MCC:APC
boundary condition: false
has part: Q13257
has part: Q9UJX6
type: Species
substance units: mole
constant: false
initial concentration: 0.0
has only substance units: false
has part: Q9H1A4
has part: Q9NYG5
has part: Q60566
has part: Q9UJX3
initial amount: NaN
has part: Q8NHZ8
has part: Q9UM13
has part: GO:0005680
has part: Q9UJX4
has part: Q13042
has part: Q12834
in compartment: metaid_0000014
has part: P30260
has part: O43684

771961
stoichiometry: 1.0
species: metaid_0000322
type: SpeciesReference

771901
stoichiometry: 1.0
species: metaid_0000016
type: SpeciesReference

metaid_0000010
constant: true
units: metaid_0000042
value: 0.2
type: Parameter

metaid_0000017
has part: Q9Y6D9
is version of: GO:0043234
constant: false
boundary condition: false
has part: Q13257
initial concentration: 0.0
in compartment: metaid_0000014
name: Mad1:C-Mad2:O-Mad2*
type: Species
has only substance units: false
initial amount: NaN
substance units: mole

metaid_0000008
constant: true
units: metaid_0000043
value: 1.0E8
type: Parameter

771757
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species: metaid_0000019
type: SpeciesReference

771781
stoichiometry: 1.0
species: metaid_0000016
type: SpeciesReference

metaid_0000023
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is version of: GO:0032092
type: Reaction
reactant: 771649
is version of: GO:0006461
product: 771673
reversible: true
fast: false
kinetic law: 771685
reactant: 771661

772057
stoichiometry: 1.0
species: metaid_0000322
type: SpeciesReference

metaid_0000016
constant: false
boundary condition: false
is: Q13257
has only substance units: false
name: O-Mad2
substance units: mole
type: Species
notes: Open conformation of Mad2
initial concentration: 1.3E-7
initial amount: NaN
in compartment: metaid_0000014

metaid_0000612
constant: true
units: metaid_0000042
value: 0.08
type: Parameter

771625
exponent: -1.0
scale: 0
multipler: 1.0
kind: MOLE
type: SBMLUnit

771829
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species: metaid_0000021
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771913
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species: metaid_0000018
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metaid_0000512
constant: true
units: metaid_0000043
value: 1.0E8
type: Parameter

metaid_0000009
constant: true
units: metaid_0000043
value: 200000.0
type: Parameter

BIOMD0000000187
area units: metaid_0000005
species: metaid_0000015
substance units: metaid_0000053
creator:
  ORG:
    orgname: Friedrich-Schiller-University Jena, Germany
  n:
    given: Peter
    family: Dittrich
time units: metaid_0000054
is version of: GO:0007094
reaction: metaid_0000024
parameter: metaid_0000004
creator:
  ORG:
    orgname: German Cancer Research Center, Heidelberg
  n:
    given: Bashar
    family: Ibrahim
creator:
  ORG:
    orgname: Fritz Lipmann Institute, Jena, Germany
  n:
    given: Eberhard
    family: Schmitt
parameter: metaid_0000512
reaction: metaid_0000225
volume units: metaid_0000004
species: metaid_0000021
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species: metaid_0000324
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parameter: metaid_0000712
parameter: metaid_0000008
species: metaid_0000022
species: metaid_0000017
units def: metaid_0000042
parameter: metaid_0000612
length unit: length
created:
  W3 CDTF: Mon Sep 01 15:18:13 BST 2008
parameter: metaid_0000045
name: Ibrahim2008 - Mitotic Spindle Assembly Checkpoint - Convey variant
parameter: metaid_0000012
reaction: metaid_0000223
reaction: metaid_0000224
is version of: REACT 2137.2
reaction: metaid_0000027
parameter: metaid_0000007
parameter: metaid_0000812
occurs in: http://identifiers.org/taxonomy/9606
species: metaid_0000322
is described by: http://identifiers.org/pubmed/18253502
modified:
  W3 CDTF: Wed Jun 05 17:39:33 BST 2013
parameter: metaid_1000007
is: MODEL6655578762
event: metaid_0000031
species: metaid_0000018
parameter: metaid_0000044
reaction: metaid_0000025
reaction: metaid_0000026
parameter: metaid_0000005
parameter: metaid_0000006
compartment: metaid_0000014
species: metaid_0000019
curated: true
species: metaid_0000020
type: SBMLModel
parameter: metaid_0000003
notes: Ibrahim2008 - Mitotic Spindle Assembly Checkpoint - Convey variant The Mitotic Spindle Assembly Checkpoint ((M)SAC) is an evolutionary conserved mechanism. This model incorporates the perspectives of three central control pathways, namely Mad1/Mad2 induced Cdc20 sequestering based on the Template Model, MCC formation, and APC inhibition. MCC:APC dissociation is described by two alternatives models, namely the "Dissociation" and the "Convey" model variants. Both these model are available in BioModels Database. This model corresponds to the "Convey" variant. This model is described in the article: In-silico modeling of the mitotic spindle assembly checkpoint. Ibrahim B, Diekmann S, Schmitt E, Dittrich P PLoS One. 2008 Feb 6;3(2):e1555. Abstract: BACKGROUND: The Mitotic Spindle Assembly Checkpoint ((M)SAC) is an evolutionary conserved mechanism that ensures the correct segregation of chromosomes by restraining cell cycle progression from entering anaphase until all chromosomes have made proper bipolar attachments to the mitotic spindle. Its malfunction can lead to cancer. PRINCIPLE FINDINGS: We have constructed and validated for the human (M)SAC mechanism an in silico dynamical model, integrating 11 proteins and complexes. The model incorporates the perspectives of three central control pathways, namely Mad1/Mad2 induced Cdc20 sequestering based on the Template Model, MCC formation, and APC inhibition. Originating from the biochemical reactions for the underlying molecular processes, non-linear ordinary differential equations for the concentrations of 11 proteins and complexes of the (M)SAC are derived. Most of the kinetic constants are taken from literature, the remaining four unknown parameters are derived by an evolutionary optimization procedure for an objective function describing the dynamics of the APC:Cdc20 complex. MCC:APC dissociation is described by two alternatives, namely the "Dissociation" and the "Convey" model variants. The attachment of the kinetochore…
species: metaid_0000323
parameter: metaid_0000010
parameter: metaid_0000011
creator:
  ORG:
    orgname: Fritz Lipmann Institute, Jena, Germany
  n:
    given: Stephan
    family: Diekmann
is part of: hsa04110
species: metaid_0000016
parameter: metaid_0000009
creator:
  ORG:
    orgname: EMBL-EBI
  n:
    given: Lukas
    family: Endler
units def: metaid_0000043

metaid_0000022
has part: Q12834
has only substance units: false
constant: false
boundary condition: false
initial amount: NaN
substance units: mole
has part: Q60566
type: Species
name: Bub3:BubR1:Cdc20
initial concentration: 0.0
has part: O43684
in compartment: metaid_0000014

771877
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species: metaid_0000022
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771973
stoichiometry: 1.0
species: metaid_0000323
type: SpeciesReference