198764
stoichiometry: 1.0
species: metaid_0000031
type: SpeciesReference

metaid_0000012
constant: true
units: metaid_0000056
value: 0.0
type: Parameter

198186
exponent: -1.0
scale: 0
multipler: 1.0
kind: LITRE
type: SBMLUnit

198306
stoichiometry: 1.0
species: metaid_0000024
type: SpeciesReference

metaid_0000054
unit: 198162
name: hour
type: SBMLUnitsDef

198452
stoichiometry: 1.0
species: metaid_0000026
type: SpeciesReference

metaid_0000022
is: GO:0005623
constant: true
size: 1.0
spatial dimensions: 3.0
name: Cell
type: Compartment

198222
exponent: -1.0
scale: 0
multipler: 3600.0
kind: SECOND
type: SBMLUnit

metaid_0000003
constant: false
units: metaid_0000055
value: 0.0
type: Parameter

198644
stoichiometry: 1.0
species: metaid_0000029
type: SpeciesReference

metaid_0000013
constant: true
units: metaid_0000057
value: 0.1177
type: Parameter

metaid_0000033
kinetic law: 198270
modifier: 198258
product: 198246
is version of: GO:0006355
is version of: GO:0009299
fast: false
reversible: false
name: Transcription
type: Reaction

metaid_0000055
unit: 198186
unit: 198174
name: nM
type: SBMLUnitsDef

BIOMD0000000185
reaction: metaid_0000037
parameter: metaid_0000011
occurs in: http://identifiers.org/taxonomy/40674
name: Locke2008_Circadian_Clock
reaction: metaid_0000036
parameter: metaid_0000010
reaction: metaid_0000048
units def: metaid_0000053
parameter: metaid_0000007
units def: metaid_0000057
is described by: http://identifiers.org/pubmed/18312618
reaction: metaid_0000040
area units: metaid_0000005
species: metaid_0000028
parameter: metaid_0000016
is version of: GO:0048512
reaction: metaid_0000047
species: metaid_0000025
parameter: metaid_0000004
parameter: metaid_0000015
reaction: metaid_0000039
species: metaid_0000030
reaction: metaid_0000051
is: MODEL9223733527
parameter: metaid_0000021
parameter: metaid_0000014
notes: The model reproduces Fig 2A of the paper. Model successfully reproduced using Jarnac and MathSBML. To the extent possible under law, all copyright and related or neighbouring rights to this encoded model have been dedicated to the public domain worldwide. Please refer to CC0 Public Domain Dedication for more information. In summary, you are entitled to use this encoded model in absolutely any manner you deem suitable, verbatim, or with modification, alone or embedded it in a larger context, redistribute it, commercially or not, in a restricted way or not. To cite BioModels Database, please use: Li C, Donizelli M, Rodriguez N, Dharuri H, Endler L, Chelliah V, Li L, He E, Henry A, Stefan MI, Snoep JL, Hucka M, Le Novère N, Laibe C (2010) BioModels Database: An enhanced, curated and annotated resource for published quantitative kinetic models. BMC Syst Biol., 4:92.
reaction: metaid_0000050
species: metaid_0000031
parameter: metaid_0000019
units def: metaid_0000055
parameter: metaid_0000018
units def: metaid_0000056
curated: true
parameter: metaid_0000006
reaction: metaid_0000043
length unit: length
species: metaid_0000029
created:
  W3 CDTF: Wed Aug 20 09:10:29 BST 2008
type: SBMLModel
reaction: metaid_0000045
reaction: metaid_0000035
parameter: metaid_0000013
reaction: metaid_0000034
reaction: metaid_0000046
parameter: metaid_0000012
modified:
  W3 CDTF: Wed Jul 11 18:47:04 BST 2012
parameter: metaid_0000009
species: metaid_0000026
parameter: metaid_0000020
parameter: metaid_0000017
time units: metaid_0000054
units def: metaid_0000054
reaction: metaid_0000049
reaction: metaid_0000038
reaction: metaid_0000041
rule: metaid_0000032
reaction: metaid_0000033
reaction: metaid_0000052
reaction: metaid_0000042
is version of: GO:0032922
creator:
  ORG:
    orgname: California Institute of Technology
  n:
    given: Harish
    family: Dharuri
reaction: metaid_0000044
parameter: metaid_0000005
substance units: metaid_0000053
species: metaid_0000024
species: metaid_0000027
parameter: metaid_0000008
volume units: metaid_0000004
parameter: metaid_0000003
compartment: metaid_0000022

metaid_0000049
kinetic law: 198728
modifier: 198716
product: 198704
fast: false
reversible: false
name: Transcriptional repressor synthesis
type: Reaction

198596
stoichiometry: 1.0
species: metaid_0000028
type: SpeciesReference

metaid_0000014
constant: true
units: metaid_0000056
value: 1.0841
type: Parameter

metaid_0000008
constant: true
units: metaid_0000055
value: 0.291
type: Parameter

metaid_0000034
kinetic law: 198294
reactant: 198282
is version of: GO:0006402
fast: false
reversible: false
name: mRNA degradation
type: Reaction

metaid_0000028
in compartment: metaid_0000022
has only substance units: false
initial concentration: 0.0
constant: false
initial amount: NaN
type: Species
name: clock gene mRNA
is version of: CHEBI:33699
boundary condition: false
encodes: O15516

198330
stoichiometry: 1.0
species: metaid_0000024
type: SpeciesReference

198174
exponent: 1.0
scale: -9
multipler: 1.0
kind: MOLE
type: SBMLUnit

metaid_0000052
kinetic law: 198813
reactant: 198801
is version of: GO:0044257
fast: false
reversible: false
name: Neuropeptide degradation
type: Reaction

198620
stoichiometry: 1.0
species: metaid_0000028
type: SpeciesReference

metaid_0000020
constant: true
units: metaid_0000056
value: 3.5216
type: Parameter

metaid_0000048
kinetic law: 198692
reactant: 198680
is version of: GO:0044257
fast: false
reversible: false
name: Protein degradation
type: Reaction

198536
stoichiometry: 1.0
species: metaid_0000028
type: SpeciesReference

198234
exponent: -1.0
scale: 0
multipler: 3600.0
kind: SECOND
type: SBMLUnit

metaid_0000015
constant: true
units: metaid_0000055
value: 8.1343
type: Parameter

metaid_0000009
constant: true
units: metaid_0000056
value: 6.7924
type: Parameter

metaid_0000053
unit: 198150
name: nano mole
type: SBMLUnitsDef

198740
stoichiometry: 1.0
species: metaid_0000030
type: SpeciesReference

metaid_0000029
is homolog to: O15516
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: metaid_0000022
name: clock protein
type: Species

metaid_0000035
kinetic law: 198318
product: 198306
is version of: GO:0045893
fast: false
reversible: false
name: Neuropeptide dependent transcription activation
type: Reaction

metaid_0000021
constant: true
units: metaid_0000055
value: 7.4519
type: Parameter

metaid_0000006
constant: true
units: dimensionless
value: 5.6645
type: Parameter

198162
exponent: 1.0
scale: 0
multipler: 3600.0
kind: SECOND
type: SBMLUnit

metaid_0000057
unit: 198234
name: hr_1
type: SBMLUnitsDef

metaid_0000031
boundary condition: false
in compartment: metaid_0000022
initial amount: NaN
name: Neuropeptide
constant: false
has version: GO:0005184
has only substance units: false
is homolog to: Q9VET0
type: Species
initial concentration: 0.0

metaid_0000041
kinetic law: 198500
modifier: 198488
product: 198476
is version of: GO:0006412
fast: false
reversible: false
name: Neuropeptide synthesis
type: Reaction

198390
stoichiometry: 1.0
species: metaid_0000025
type: SpeciesReference

metaid_0000047
kinetic law: 198668
modifier: 198656
product: 198644
is version of: GO:0006412
fast: false
reversible: false
name: Translation
type: Reaction

metaid_0000016
constant: true
units: metaid_0000057
value: 0.3352
type: Parameter

metaid_0000050
kinetic law: 198752
reactant: 198740
is version of: GO:0044257
fast: false
reversible: false
name: Transcriptional repressor degradation
type: Reaction

metaid_0000026
constant: false
boundary condition: false
has only substance units: false
initial concentration: 2.25
initial amount: NaN
in compartment: metaid_0000022
name: Transcriptional repressor
type: Species

metaid_0000036
kinetic law: 198342
product: 198330
is version of: GO:0045893
fast: false
reversible: false
name: Light dependent transcription activation
type: Reaction

198246
stoichiometry: 1.0
species: metaid_0000024
type: SpeciesReference

metaid_0000007
constant: true
units: metaid_0000056
value: 8.4297
type: Parameter

metaid_0000040
kinetic law: 198464
reactant: 198452
is version of: GO:0044257
fast: false
reversible: false
name: Transcriptional repressor degradation
type: Reaction

metaid_0000056
unit: 198222
unit: 198210
unit: 198198
name: nM_hr_1
type: SBMLUnitsDef

metaid_0000030
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: metaid_0000022
name: Transcriptional repressor
type: Species

metaid_0000017
constant: true
units: metaid_0000056
value: 4.6645
type: Parameter

metaid_0000046
kinetic law: 198632
product: 198620
is version of: GO:0045893
fast: false
reversible: false
name: Light dependent transcription activation
type: Reaction

metaid_0000051
kinetic law: 198788
modifier: 198776
product: 198764
is version of: GO:0006412
fast: false
reversible: false
name: Neuropeptide synthesis
type: Reaction

metaid_0000027
boundary condition: false
is homolog to: Q9VET0
has only substance units: false
constant: false
has version: GO:0005184
type: Species
initial amount: NaN
name: Neuropeptide
in compartment: metaid_0000022
initial concentration: 2.5

198572
stoichiometry: 1.0
species: metaid_0000028
type: SpeciesReference

metaid_0000037
kinetic law: 198378
modifier: 198366
product: 198354
is version of: GO:0006412
fast: false
reversible: false
name: Translation
type: Reaction

198414
stoichiometry: 1.0
species: metaid_0000026
type: SpeciesReference

metaid_0000010
constant: true
units: dimensionless
value: 1.0
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198801
stoichiometry: 1.0
species: metaid_0000031
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198354
stoichiometry: 1.0
species: metaid_0000025
type: SpeciesReference

metaid_0000018
constant: true
units: metaid_0000055
value: 9.9849
type: Parameter

198150
exponent: 1.0
scale: -9
multipler: 1.0
kind: MOLE
type: SBMLUnit

metaid_0000045
kinetic law: 198608
product: 198596
is version of: GO:0045893
fast: false
reversible: false
name: Neuropeptide dependent transcription activation
type: Reaction

metaid_0000043
kinetic law: 198560
modifier: 198548
product: 198536
is version of: GO:0006355
is version of: GO:0009299
fast: false
reversible: false
name: Transcription
type: Reaction

metaid_0000024
initial amount: NaN
encodes: O15516
in compartment: metaid_0000022
has only substance units: false
is version of: CHEBI:33699
name: clock gene mRNA
boundary condition: false
initial concentration: 4.25
constant: false
type: Species

metaid_0000004
constant: true
units: metaid_0000056
value: 6.8355
type: Parameter

metaid_0000038
kinetic law: 198402
reactant: 198390
is version of: GO:0044257
fast: false
reversible: false
name: Protein degradation
type: Reaction

metaid_0000011
constant: true
units: metaid_0000055
value: 4.8283
type: Parameter

198282
stoichiometry: 1.0
species: metaid_0000024
type: SpeciesReference

metaid_0000039
kinetic law: 198440
modifier: 198427
product: 198414
fast: false
reversible: false
name: Transcriptional repressor synthesis
type: Reaction

metaid_0000019
constant: true
units: metaid_0000057
value: 0.2282
type: Parameter

198476
stoichiometry: 1.0
species: metaid_0000027
type: SpeciesReference

198198
exponent: 1.0
scale: -9
multipler: 1.0
kind: MOLE
type: SBMLUnit

metaid_0000042
kinetic law: 198524
reactant: 198512
is version of: GO:0044257
fast: false
reversible: false
name: Neuropeptide degradation
type: Reaction

metaid_0000044
kinetic law: 198584
reactant: 198572
is version of: GO:0006402
fast: false
reversible: false
name: mRNA degradation
type: Reaction

198704
stoichiometry: 1.0
species: metaid_0000030
type: SpeciesReference

metaid_0000025
is homolog to: O15516
constant: false
boundary condition: false
has only substance units: false
initial concentration: 3.25
initial amount: NaN
in compartment: metaid_0000022
name: clock protein
type: Species

198680
stoichiometry: 1.0
species: metaid_0000029
type: SpeciesReference

198210
exponent: -1.0
scale: 0
multipler: 1.0
kind: LITRE
type: SBMLUnit

metaid_0000005
constant: true
units: metaid_0000055
value: 2.7266
type: Parameter

198512
stoichiometry: 1.0
species: metaid_0000027
type: SpeciesReference