metaid_0000196
constant: true
value: 0.0791
name: kon37
type: Parameter

metaid_0000083
constant: true
value: 2.225
name: koff25
type: Parameter

840995
stoichiometry: 1.0
species: metaid_0000335
type: SpeciesReference

W3 CDTF: Tue Apr 21 21:13:48 BST 2009

839837
stoichiometry: 1.0
species: metaid_0000267
type: SpeciesReference

836523
stoichiometry: 1.0
species: metaid_0000260
type: SpeciesReference

metaid_0000443
kinetic law: 841707
modifier: 841695
product: 841683
reactant: 841671
fast: false
reversible: true
name: Net E_E1 S/T Phosphorylation
type: Reaction

840331
stoichiometry: 1.0
species: metaid_0000326
type: SpeciesReference

metaid_0000121
constant: true
value: 1.2237
name: koff77
type: Parameter

842327
stoichiometry: 1.0
species: metaid_0000304
type: SpeciesReference

842631
stoichiometry: 1.0
species: metaid_0000360
type: SpeciesReference

metaid_0000423
kinetic law: 840403
modifier: 840391
product: 840379
reactant: 840367
fast: false
reversible: true
name: Net E14 Phosphorylation
type: Reaction

metaid_0000101
constant: true
value: 3.5195
name: koff42
type: Parameter

839789
stoichiometry: 1.0
species: metaid_0000314
type: SpeciesReference

836776
stoichiometry: 1.0
species: metaid_0000270
type: SpeciesReference

metaid_0000044
constant: true
value: 545.4408
name: Kmf52
type: Parameter

836197
stoichiometry: 1.0
species: metaid_0000253
type: SpeciesReference

841236
stoichiometry: 1.0
species: metaid_0000336
type: SpeciesReference

837127
stoichiometry: 1.0
species: metaid_0000294
type: SpeciesReference

metaid_0000084
constant: true
value: 0.0103
name: koff26
type: Parameter

837995
stoichiometry: 1.0
species: metaid_0000285
type: SpeciesReference

840295
stoichiometry: 1.0
species: metaid_0000325
type: SpeciesReference

metaid_0000444
kinetic law: 841755
modifier: 841743
product: 841731
reactant: 841719
fast: false
reversible: true
name: Net H_E4 S/T Phosphorylation
type: Reaction

metaid_0000197
constant: true
value: 0.0076
name: kon78
type: Parameter

metaid_0000120
constant: true
value: 2.1542
name: koff76
type: Parameter

841321
stoichiometry: 1.0
species: metaid_0000345
type: SpeciesReference

metaid_0000424
reactant: 840415
type: Reaction
fast: false
reversible: true
product: 840439
kinetic law: 840500
modifier: 840463
modifier: 840487
product: 840451
name: Net E13/Grb2 Binding
modifier: 840475
reactant: 840427

839595
stoichiometry: 1.0
species: metaid_0000294
type: SpeciesReference

metaid_0000100
constant: true
value: 7.0487
name: koff41
type: Parameter

837187
stoichiometry: 1.0
species: metaid_0000275
type: SpeciesReference

836571
stoichiometry: 1.0
species: metaid_0000261
type: SpeciesReference

metaid_0000043
constant: true
value: 199.2773
name: Vmaxr52
type: Parameter

840054
stoichiometry: 1.0
species: metaid_0000268
type: SpeciesReference

841527
stoichiometry: 1.0
species: metaid_0000244
type: SpeciesReference

839103
stoichiometry: 1.0
species: metaid_0000293
type: SpeciesReference

metaid_0000081
constant: true
value: 2.3619
name: koff23
type: Parameter

metaid_0000194
constant: true
value: 0.0602
name: kon35
type: Parameter

836849
stoichiometry: 1.0
species: metaid_0000266
type: SpeciesReference

metaid_0000441
kinetic law: 841611
modifier: 841599
product: 841587
reactant: 841575
fast: false
reversible: true
name: Net E2 S/T Phosphorylation
type: Reaction

841886
stoichiometry: 1.0
species: metaid_0000336
type: SpeciesReference

metaid_0000421
kinetic law: 840307
product: 840295
reactant: 840283
reactant: 840271
fast: false
reversible: true
name: ErbB1/ErbB4 Heterodimerization
type: Reaction

metaid_0000042
constant: true
value: 0.7745
name: kf52
type: Parameter

841188
stoichiometry: 1.0
species: metaid_0000339
type: SpeciesReference

metaid_0000082
constant: true
value: 4.4226
name: koff24
type: Parameter

W3 CDTF: Thu Jul 17 14:46:08 BST 2008

metaid_0000195
constant: true
value: 0.0043
name: kon36
type: Parameter

metaid_0000442
kinetic law: 841659
modifier: 841647
product: 841635
reactant: 841623
fast: false
reversible: true
name: Net E4 S/T Phosphorylation
type: Reaction

840693
stoichiometry: 1.0
species: metaid_0000294
type: SpeciesReference

metaid_0000239
constant: true
value: 0.1993
name: kon95
type: Parameter

metaid_0000041
constant: true
value: 988.4496
name: Kmrb51
type: Parameter

841990
stoichiometry: 1.0
species: metaid_0000291
type: SpeciesReference

metaid_0000259
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: metaid_0000243
name: E23_p
type: Species

metaid_0000422
kinetic law: 840355
modifier: 840343
product: 840331
reactant: 840319
fast: false
reversible: true
name: Net E13 Phosphorylation
type: Reaction

842224
stoichiometry: 1.0
species: metaid_0000353
type: SpeciesReference

836173
stoichiometry: 1.0
species: metaid_0000249
type: SpeciesReference

metaid_0000125
constant: true
value: 83.4465
name: kPTP38
type: Parameter

metaid_0000020
constant: true
value: 486.1398
name: KmPY
type: Parameter

841819
stoichiometry: 1.0
species: metaid_0000348
type: SpeciesReference

837826
stoichiometry: 1.0
species: metaid_0000291
type: SpeciesReference

ORG:
  orgname: EMBL-EBI
n:
  given: Lukas
  family: Endler

838778
stoichiometry: 1.0
species: metaid_0000268
type: SpeciesReference

840971
stoichiometry: 1.0
species: metaid_0000327
type: SpeciesReference

836318
stoichiometry: 1.0
species: metaid_0000250
type: SpeciesReference

metaid_0000040
constant: true
value: 346.4779
name: Kmr51
type: Parameter

metaid_0000447
kinetic law: 841925
product: 841912
product: 841899
reactant: 841886
reactant: 841872
fast: false
reversible: true
name: PTP1B binding to SigAP
type: Reaction

metaid_0000238
constant: true
value: 0.9966
name: kcat94
type: Parameter

metaid_0000124
constant: true
value: 2.9373
name: koff80
type: Parameter

metaid_0000237
constant: true
value: 100.0037
name: koff93
type: Parameter

837163
stoichiometry: 1.0
species: metaid_0000259
type: SpeciesReference

837488
stoichiometry: 1.0
species: metaid_0000263
type: SpeciesReference

840078
stoichiometry: 1.0
species: metaid_0000295
type: SpeciesReference

metaid_0000210
constant: true
value: 0.0148
name: kon46
type: Parameter

metaid_0000080
constant: true
value: 3.6962
name: koff22
type: Parameter

837103
stoichiometry: 1.0
species: metaid_0000266
type: SpeciesReference

metaid_0000060
constant: true
value: 389.1061
name: kf50
type: Parameter

838356
stoichiometry: 1.0
species: metaid_0000266
type: SpeciesReference

840271
stoichiometry: 1.0
species: metaid_0000250
type: SpeciesReference

metaid_0000420
kinetic law: 840259
product: 840247
reactant: 840235
reactant: 840223
fast: false
reversible: true
name: ErbB1/ErbB3 Heterodimerization
type: Reaction

metaid_0000448
kinetic law: 841964
product: 841951
reactant: 841938
fast: false
reversible: false
name: E11P Degradation
type: Reaction

839067
stoichiometry: 1.0
species: metaid_0000297
type: SpeciesReference

metaid_0000123
constant: true
value: 1.1852
name: koff79
type: Parameter

metaid_0000198
constant: true
value: 0.0078
name: kon79
type: Parameter

metaid_0000236
constant: true
value: 0.2003
name: kon93
type: Parameter

837271
stoichiometry: 1.0
species: metaid_0000264
type: SpeciesReference

metaid_0000445
kinetic law: 841806
modifier: 841793
product: 841780
reactant: 841767
fast: false
reversible: true
name: EGF binding to E1-PT
type: Reaction

840826
stoichiometry: 1.0
species: metaid_0000327
type: SpeciesReference

838417
stoichiometry: 1.0
species: metaid_0000292
type: SpeciesReference

840911
stoichiometry: 1.0
species: metaid_0000327
type: SpeciesReference

metaid_0000122
constant: true
value: 0.2007
name: koff78
type: Parameter

metaid_0000199
constant: true
value: 0.0123
name: kon65
type: Parameter

metaid_0000446
kinetic law: 841858
modifier: 841845
product: 841832
reactant: 841819
fast: false
reversible: true
name: HRG binding to E4-PT
type: Reaction

metaid_0000235
constant: true
value: 0.2004
name: kcat92
type: Parameter

841164
stoichiometry: 1.0
species: metaid_0000259
type: SpeciesReference

837911
stoichiometry: 1.0
species: metaid_0000284
type: SpeciesReference

839379
stoichiometry: 1.0
species: metaid_0000307
type: SpeciesReference

840525
stoichiometry: 1.0
species: metaid_0000264
type: SpeciesReference

842133
stoichiometry: 1.0
species: metaid_0000337
type: SpeciesReference

metaid_0000129
constant: true
value: 1.361
name: kf81
type: Parameter

metaid_0000310
initial concentration: NaN
name: RasGTP
in compartment: metaid_0000243
initial amount: 0.0
constant: false
has version: IPR013753
type: Species
has part: CHEBI:15996
has only substance units: false
boundary condition: false
has part: P01112

metaid_0000254
initial concentration: NaN
has only substance units: false
boundary condition: false
type: Species
has part: P21860
has part: Q02297
has part: Q15303
constant: false
initial amount: 0.0
in compartment: metaid_0000243
name: (HRG-ErbB3/4)2

metaid_0000063
constant: true
value: 0.5194
name: koff46
type: Parameter

840862
stoichiometry: 1.0
species: metaid_0000292
type: SpeciesReference

840319
stoichiometry: 1.0
species: metaid_0000324
type: SpeciesReference

metaid_0000276
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: metaid_0000243
name: E23-Shc
type: Species

metaid_0000213
constant: true
value: 1.1994E-4
name: kon60
type: Parameter

835932
stoichiometry: 1.0
species: metaid_0000244
type: SpeciesReference

839740
stoichiometry: 1.0
species: metaid_0000312
type: SpeciesReference

841369
stoichiometry: 1.0
species: metaid_0000342
type: SpeciesReference

metaid_0000177
constant: true
value: 0.0133
name: kon74
type: Parameter

metaid_0000234
constant: true
value: 99.9983
name: koff91
type: Parameter

metaid_0000109
constant: true
value: 29.8531
name: kPTP10
type: Parameter

842764
stoichiometry: 1.0
species: metaid_0000359
type: SpeciesReference

metaid_0000311
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: metaid_0000243
name: Sum RasGAP_p
type: Species

metaid_0000128
constant: true
value: 96.5716
name: kPTP50
type: Parameter

metaid_0000253
in compartment: metaid_0000243
has part: P04626
has only substance units: false
initial concentration: NaN
type: Species
has part: Q02297
boundary condition: false
has part: P21860
constant: false
initial amount: 0.0
name: HRG-ErbB3-ErbB2

metaid_0000064
constant: true
value: 0.0175
name: EGF_off
type: Parameter

BIOMD0000000175
parameter: metaid_0000234
reaction: metaid_0000405
parameter: metaid_0000115
reaction: metaid_0000426
parameter: metaid_0000136
species: metaid_0000360
species: metaid_0000354
parameter: metaid_0000215
reaction: metaid_0000379
species: metaid_0000258
parameter: metaid_0000179
parameter: metaid_0000072
parameter: metaid_0000109
parameter: metaid_0000151
species: metaid_0000333
parameter: metaid_0000172
species: metaid_0000276
parameter: metaid_0000053
reaction: metaid_0000412
species: metaid_0000263
parameter: metaid_0000145
reaction: metaid_0000388
reaction: metaid_0000427
parameter: metaid_0000026
parameter: metaid_0000137
parameter: metaid_0000216
parameter: metaid_0000207
parameter: metaid_0000237
parameter: metaid_0000081
species: metaid_0000348
parameter: metaid_0000118
reaction: metaid_0000421
parameter: metaid_0000173
reaction: metaid_0000442
species: metaid_0000346
species: metaid_0000281
parameter: metaid_0000054
parameter: metaid_0000075
species: metaid_0000327
parameter: metaid_0000154
reaction: metaid_0000462
parameter: metaid_0000027
species: metaid_0000325
parameter: metaid_0000048
parameter: metaid_0000238
species: metaid_0000351
species: metaid_0000301
species: metaid_0000255
parameter: metaid_0000119
species: metaid_0000296
parameter: metaid_0000182
parameter: metaid_0000020
parameter: metaid_0000210
reaction: metaid_0000443
reaction: metaid_0000402
parameter: metaid_0000112
species: metaid_0000330
species: metaid_0000294
parameter: metaid_0000076
parameter: metaid_0000155
parameter: metaid_0000176
species: metaid_0000289
parameter: metaid_0000057
reaction: metaid_0000368
reaction: metaid_0000463
type: SBMLModel
species: metaid_0000317
species: metaid_0000273
parameter: metaid_0000149
species: metaid_0000260
parameter: metaid_0000240
species: metaid_0000309
reaction: metaid_0000403
parameter: metaid_0000085
reaction: metaid_0000364
species: metaid_0000465
rule: metaid_0000466
reaction: metaid_0000385
parameter: metaid_0000113
species: metaid_0000343

840018
stoichiometry: 1.0
species: metaid_0000323
type: SpeciesReference

metaid_0000275
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: metaid_0000243
name: E23-Grb2
type: Species

metaid_0000214
constant: true
value: 33.3
name: VeVc
type: Parameter

842679
stoichiometry: 1.0
species: metaid_0000356
type: SpeciesReference

837597
stoichiometry: 1.0
species: metaid_0000280
type: SpeciesReference

841309
stoichiometry: 1.0
species: metaid_0000341
type: SpeciesReference

837718
stoichiometry: 1.0
species: metaid_0000260
type: SpeciesReference

metaid_0000176
constant: true
value: 0.0114
name: kon21
type: Parameter

metaid_0000233
constant: true
value: 0.1966
name: kon91
type: Parameter

metaid_0000108
constant: true
value: 500.0
name: PTP1B_Abund
type: Parameter

metaid_0000252
name: EGF-ErbB1-ErbB2
initial amount: 0.0
initial concentration: NaN
has only substance units: false
has part: P00533
has part: P01133
boundary condition: false
type: Species
in compartment: metaid_0000243
has part: P04626
constant: false

842619
stoichiometry: 1.0
species: metaid_0000317
type: SpeciesReference

841140
stoichiometry: 1.0
species: metaid_0000345
type: SpeciesReference

metaid_0000278
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: metaid_0000243
name: E23-RasGAP
type: Species

metaid_0000391
product: 837826
name: Net E24P/Grb2 binding
modifier: 837862
fast: false
type: Reaction
reactant: 837790
reactant: 837802
modifier: 837850
modifier: 837838
kinetic law: 837874
product: 837814
reversible: true

metaid_0000061
constant: true
value: 0.0849
name: a98
type: Parameter

metaid_0000175
constant: true
value: 0.0478
name: kon20
type: Parameter

metaid_0000211
constant: true
value: 0.0215
name: kon58
type: Parameter

metaid_0000371
kinetic law: 836402
modifier: 836390
product: 836378
reactant: 836366
is version of: GO:0006468
fast: false
reversible: true
name: Net E11 Phosphorylation
type: Reaction

840935
stoichiometry: 1.0
species: metaid_0000334
type: SpeciesReference

metaid_0000089
constant: true
value: 1.2204
name: koff31
type: Parameter

metaid_0000232
constant: true
value: 20.0037
name: kcat90
type: Parameter

metaid_0000107
constant: true
value: 2.8871
name: koff68
type: Parameter

836619
stoichiometry: 1.0
species: metaid_0000262
type: SpeciesReference

metaid_0000127
constant: true
value: 3.9255
name: koff88
type: Parameter

837670
stoichiometry: 1.0
species: metaid_0000265
type: SpeciesReference

836041
stoichiometry: 1.0
species: metaid_0000250
type: SpeciesReference

metaid_0000390
kinetic law: 837778
fast: false
type: Reaction
reversible: true
product: 837742
name: Net E34P/RasGAP binding
product: 837754
reactant: 837730
modifier: 837766
reactant: 837718

metaid_0000277
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: metaid_0000243
name: E23-PI-3K
type: Species

metaid_0000251
initial amount: 0.0
name: (EGF-ErbB1)2
initial concentration: NaN
constant: false
in compartment: metaid_0000243
has only substance units: false
boundary condition: false
type: Species
has part: P00533
has part: P01133

metaid_0000062
constant: true
value: 0.1833
name: b98
type: Parameter

837658
stoichiometry: 1.0
species: metaid_0000260
type: SpeciesReference

metaid_0000212
constant: true
value: 0.0077
name: kon59
type: Parameter

metaid_0000370
kinetic law: 836354
product: 836342
reactant: 836330
reactant: 836318
is version of: GO:0046983
fast: false
reversible: true
name: ErbB4 Homodimerization
type: Reaction

metaid_0000106
constant: true
value: 9.172
name: koff59
type: Parameter

842583
stoichiometry: 1.0
species: metaid_0000317
type: SpeciesReference

metaid_0000231
constant: true
value: 99.9637
name: koff89
type: Parameter

metaid_0000174
constant: true
value: 0.0896
name: kon19
type: Parameter

metaid_0000126
constant: true
value: 79.6132
name: kPTP39
type: Parameter

metaid_0000393
kinetic law: 838019
product: 838007
product: 837995
reactant: 837983
reactant: 837971
fast: false
reversible: true
name: Net E24P/PI3K binding
type: Reaction

metaid_0000400
modifier: 838658
modifier: 838670
reactant: 838561
reversible: true
modifier: 838646
modifier: 838682
fast: false
product: 838574
modifier: 838634
name: Net Gab1 Phosphorylation
modifier: 838610
type: Reaction
modifier: 838622
kinetic law: 838694
modifier: 838586
modifier: 838598

metaid_0000153
constant: true
value: 0.0334
name: kon3
type: Parameter

metaid_0000217
constant: true
value: 0.8048
name: kon61
type: Parameter

841345
stoichiometry: 1.0
species: metaid_0000262
type: SpeciesReference

metaid_0000105
constant: true
value: 6.3059
name: koff58
type: Parameter

metaid_0000314
is version of: Q02750
in compartment: metaid_0000243
is described by: http://identifiers.org/omim/176872
initial concentration: NaN
initial amount: 772.0
is version of: A4QPA9
constant: false
name: MEK
has only substance units: false
boundary condition: false
type: Species

metaid_0000258
has part: P00533
has part: P04626
has only substance units: false
boundary condition: false
has version: C00562
initial concentration: NaN
type: Species
initial amount: 0.0
name: E12_p
in compartment: metaid_0000243
constant: false

842788
stoichiometry: 1.0
species: metaid_0000360
type: SpeciesReference

metaid_0000067
constant: true
value: 0.1717
name: koff4
type: Parameter

837971
stoichiometry: 1.0
species: metaid_0000261
type: SpeciesReference

metaid_0000173
constant: true
value: 0.0116
name: kon73
type: Parameter

metaid_0000230
constant: true
value: 0.1997
name: kon89
type: Parameter

839535
stoichiometry: 1.0
species: metaid_0000310
type: SpeciesReference

metaid_0000087
constant: true
value: 2.0148
name: koff29
type: Parameter

metaid_0000192
constant: true
value: 0.0101
name: kon77
type: Parameter

metaid_0000328
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: metaid_0000243
name: E13-Grb2
type: Species

838224
stoichiometry: 1.0
species: metaid_0000288
type: SpeciesReference

metaid_0000279
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: metaid_0000243
name: E34-Grb2
type: Species

metaid_0000392
modifier: 837947
type: Reaction
product: 837923
modifier: 837935
reactant: 837887
name: Net E24P/Shc binding
fast: false
product: 837911
reversible: true
kinetic law: 837959
reactant: 837899

metaid_0000218
constant: true
value: 1.782
name: kon62
type: Parameter

841683
stoichiometry: 1.0
species: metaid_0000349
type: SpeciesReference

metaid_0000152
constant: true
value: 0.0059
name: kon2
type: Parameter

metaid_0000257
name: E11_p
has part: P00533
type: Species
boundary condition: false
initial amount: 0.0
initial concentration: NaN
has version: C00562
constant: false
in compartment: metaid_0000243
has only substance units: false

metaid_0000104
constant: true
value: 3.9967
name: koff45
type: Parameter

metaid_0000068
constant: true
value: 4.3985
name: koff5
type: Parameter

metaid_0000172
constant: true
value: 0.0117
name: kon18
type: Parameter

metaid_0000088
constant: true
value: 4.9936
name: koff30
type: Parameter

metaid_0000440
kinetic law: 841563
modifier: 841551
product: 841539
reactant: 841527
fast: false
reversible: true
name: Net E1 S/T Phosphorylation
type: Reaction

836861
stoichiometry: 1.0
species: metaid_0000271
type: SpeciesReference

metaid_0000315
constant: false
is version of: A4QPA9
initial amount: 0.0
type: Species
in compartment: metaid_0000243
is version of: Q02750
has only substance units: false
initial concentration: NaN
is described by: http://identifiers.org/omim/176872
boundary condition: false
is version of: C00562
name: MEK*

metaid_0000193
constant: true
value: 1.0E-4
name: kon34
type: Parameter

metaid_0000329
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: metaid_0000243
name: E13-Shc
type: Species

metaid_0000299
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: metaid_0000243
name: Sum Grb2-Gab1
type: Species

839945
stoichiometry: 1.0
species: metaid_0000305
type: SpeciesReference

836463
stoichiometry: 1.0
species: metaid_0000253
type: SpeciesReference

840609
stoichiometry: 1.0
species: metaid_0000265
type: SpeciesReference

841297
stoichiometry: 1.0
species: metaid_0000336
type: SpeciesReference

metaid_0000395
product: 838127
type: Reaction
modifier: 838175
kinetic law: 838187
product: 838139
reactant: 838115
fast: false
reversible: true
reactant: 838103
name: Net E44P/RasGAP binding
modifier: 838151
modifier: 838163

metaid_0000065
constant: true
value: 9.0E-4
name: HRGoff_3
type: Parameter

metaid_0000256
constant: false
name: (HRG-Erb4)2
has only substance units: false
boundary condition: false
has part: Q02297
has part: Q15303
initial concentration: NaN
type: Species
initial amount: 0.0
in compartment: metaid_0000243

metaid_0000312
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 743.0
in compartment: metaid_0000243
name: Raf
type: Species

metaid_0000151
constant: true
value: 0.0038
name: kon86
type: Parameter

metaid_0000103
constant: true
value: 0.4265
name: koff44
type: Parameter

metaid_0000171
constant: true
value: 0.0049
name: kon17
type: Parameter

838730
stoichiometry: 1.0
species: metaid_0000298
type: SpeciesReference

841418
stoichiometry: 1.0
species: metaid_0000336
type: SpeciesReference

metaid_0000190
constant: true
value: 9.0E-4
name: kon32
type: Parameter

metaid_0000085
constant: true
value: 1.8922
name: koff27
type: Parameter

metaid_0000215
constant: true
value: 4.9981
name: koff60
type: Parameter

metaid_0000216
constant: true
value: 5.229
name: koff61
type: Parameter

metaid_0000394
product: 838055
reactant: 838031
modifier: 838079
fast: false
reactant: 838043
reversible: true
product: 838067
kinetic law: 838091
name: Net E24P/RasGAP binding
type: Reaction

836101
stoichiometry: 1.0
species: metaid_0000251
type: SpeciesReference

metaid_0000066
constant: true
value: 0.0973
name: HRGoff_4
type: Parameter

metaid_0000255
type: Species
has only substance units: false
in compartment: metaid_0000243
has part: P04626
has part: Q02297
has part: Q15303
constant: false
initial concentration: NaN
initial amount: 0.0
name: HRG-Erb4-ErbB2
boundary condition: false

metaid_0000313
is version of: C00562
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: metaid_0000243
name: Raf*
type: Species

metaid_0000102
constant: true
value: 0.5441
name: koff43
type: Parameter

842055
stoichiometry: 1.0
species: metaid_0000264
type: SpeciesReference

metaid_0000150
constant: true
value: 1.0086E-4
name: kon1
type: Parameter

metaid_0000170
constant: true
value: 0.0097
name: kon16
type: Parameter

841503
stoichiometry: 1.0
species: metaid_0000345
type: SpeciesReference

837694
stoichiometry: 1.0
species: metaid_0000293
type: SpeciesReference

metaid_0000191
constant: true
value: 0.0335
name: kon33
type: Parameter

metaid_0000086
constant: true
value: 4.6432
name: koff28
type: Parameter

metaid_0000337
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: metaid_0000243
name: E11-PTP-1B
type: Species

metaid_0000462
kinetic law: 842752
product: 842740
reactant: 842727
reactant: 842715
fast: false
reversible: true
name: pERK binding to Phosphatase
type: Reaction

metaid_0000357
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: metaid_0000243
name: ERK-MEK*
type: Species

836294
stoichiometry: 1.0
species: metaid_0000255
type: SpeciesReference

837379
stoichiometry: 1.0
species: metaid_0000293
type: SpeciesReference

metaid_0000307
initial amount: 0.0
type: Species
boundary condition: false
has only substance units: false
initial concentration: NaN
is: CHEBI:16618
in compartment: metaid_0000243
constant: false
is: C05981
name: PIP3

metaid_0000376
kinetic law: 836643
modifier: 836631
product: 836619
reactant: 836607
fast: false
reversible: true
name: Net E44 Phosphorylation
type: Reaction

metaid_0000295
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: metaid_0000243
name: Sum Gab1
type: Species

metaid_0000396
fast: false
type: Reaction
name: Net E44P/Shc binding
product: 838224
kinetic law: 838272
reversible: true
product: 838236
modifier: 838260
modifier: 838248
reactant: 838199
reactant: 838212

838127
stoichiometry: 1.0
species: metaid_0000287
type: SpeciesReference

836125
stoichiometry: 1.0
species: metaid_0000248
type: SpeciesReference

metaid_0000156
constant: true
value: 2.5427
name: kon5
type: Parameter

840597
stoichiometry: 1.0
species: metaid_0000326
type: SpeciesReference

840223
stoichiometry: 1.0
species: metaid_0000249
type: SpeciesReference

metaid_0000461
kinetic law: 842703
product: 842691
product: 842679
reactant: 842667
fast: false
reversible: false
name: ERKstar dephosphorylation
type: Reaction

metaid_0000296
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: metaid_0000243
name: Sum Shc_p
type: Species

838067
stoichiometry: 1.0
species: metaid_0000294
type: SpeciesReference

841587
stoichiometry: 1.0
species: metaid_0000347
type: SpeciesReference

metaid_0000356
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: metaid_0000243
name: p_ERK
type: Species

metaid_0000306
constant: false
initial concentration: NaN
in compartment: metaid_0000243
type: Species
name: PIP2
has only substance units: false
is: C04637
is: CHEBI:28910
initial amount: 197.0
boundary condition: false

841248
stoichiometry: 1.0
species: metaid_0000340
type: SpeciesReference

metaid_0000377
product: 836679
modifier: 836728
modifier: 836703
kinetic law: 836740
fast: false
reactant: 836655
type: Reaction
product: 836691
modifier: 836715
name: Net E11P/Grb2 binding
reversible: true
reactant: 836667

metaid_0000397
kinetic law: 838332
product: 838320
product: 838308
reactant: 838296
reactant: 838284
fast: false
reversible: true
name: Net E44P/PI3K binding
type: Reaction

metaid_0000336
boundary condition: false
initial concentration: NaN
initial amount: 500.0
is described by: http://identifiers.org/omim/176885
has only substance units: false
is version of: P18031
constant: false
type: Species
name: PTP-1B
in compartment: metaid_0000243

metaid_0000209
constant: true
value: 0.0108
name: kon88
type: Parameter

metaid_0000157
constant: true
value: 0.2283
name: kon6
type: Parameter

840537
stoichiometry: 1.0
species: metaid_0000329
type: SpeciesReference

metaid_0000297
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: metaid_0000243
name: Sum Gab1_p
type: Species

metaid_0000464
constant: false
boundary condition: true
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: metaid_0000243
name: normalized Akt*
type: Species

842534
stoichiometry: 1.0
species: metaid_0000315
type: SpeciesReference

metaid_0000339
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: metaid_0000243
name: E23-PTP-1B
type: Species

metaid_0000378
modifier: 836813
modifier: 836801
reactant: 836764
type: Reaction
product: 836788
name: Net E11P/Shc binding
kinetic law: 836825
reversible: true
fast: false
reactant: 836752
product: 836776

839019
stoichiometry: 1.0
species: metaid_0000292
type: SpeciesReference

836679
stoichiometry: 1.0
species: metaid_0000269
type: SpeciesReference

metaid_0000305
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: metaid_0000243
name: PIP3-Gab1
type: Species

836933
stoichiometry: 1.0
species: metaid_0000272
type: SpeciesReference

metaid_0000398
product: 838368
kinetic law: 838405
reversible: true
product: 838380
reactant: 838356
reactant: 838344
modifier: 838392
name: Net E44P/RasGAP binding
type: Reaction
fast: false

837730
stoichiometry: 1.0
species: metaid_0000266
type: SpeciesReference

metaid_0000154
constant: true
value: 8.0E-4
name: kon87
type: Parameter

metaid_0000359
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: metaid_0000243
name: p_ERK-ERKpase
type: Species

metaid_0000029
constant: true
value: 693.5786
name: PTEN
type: Parameter

metaid_0000208
constant: true
value: 0.0028
name: kon45
type: Parameter

metaid_0000358
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: metaid_0000243
name: p_ERK-MEK*
type: Species

836221
stoichiometry: 1.0
species: metaid_0000249
type: SpeciesReference

metaid_0000298
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: metaid_0000243
name: Sum Grb2-SOS
type: Species

metaid_0000338
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: metaid_0000243
name: E12-PTP-1B
type: Species

839331
stoichiometry: 1.0
species: metaid_0000351
type: SpeciesReference

metaid_0000463
kinetic law: 842800
product: 842788
product: 842776
reactant: 842764
fast: false
reversible: false
name: pERK dephosphorylation
type: Reaction

metaid_0000379
reversible: true
name: Net E11P/RasGAP binding
reactant: 836837
fast: false
type: Reaction
product: 836873
kinetic law: 836897
modifier: 836885
reactant: 836849
product: 836861

metaid_0000304
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: metaid_0000243
name: Empty
type: Species

838308
stoichiometry: 1.0
species: metaid_0000289
type: SpeciesReference

metaid_0000069
constant: true
value: 2.6619
name: koff6
type: Parameter

840042
stoichiometry: 1.0
species: metaid_0000298
type: SpeciesReference

metaid_0000270
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: metaid_0000243
name: E11-Shc
type: Species

metaid_0000399
modifier: 838525
name: Net Shc Phosphorylation
modifier: 838489
fast: false
type: Reaction
modifier: 838465
kinetic law: 838549
modifier: 838501
reversible: true
modifier: 838537
reactant: 838417
modifier: 838477
modifier: 838453
modifier: 838513
product: 838429
modifier: 838441

metaid_0000207
constant: true
value: 0.0122
name: kon44
type: Parameter

metaid_0000155
constant: true
value: 0.5005
name: kon4
type: Parameter

metaid_0000291
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: metaid_0000243
name: Sum Grb2
type: Species

838718
stoichiometry: 1.0
species: metaid_0000267
type: SpeciesReference

838380
stoichiometry: 1.0
species: metaid_0000294
type: SpeciesReference

838296
stoichiometry: 1.0
species: metaid_0000265
type: SpeciesReference

840247
stoichiometry: 1.0
species: metaid_0000324
type: SpeciesReference

metaid_0000372
kinetic law: 836451
modifier: 836438
product: 836426
reactant: 836414
is version of: GO:0006468
fast: false
reversible: true
name: Net E12 Phosphorylation
type: Reaction

metaid_0000333
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: metaid_0000243
name: E14-Shc
type: Species

836270
stoichiometry: 1.0
species: metaid_0000250
type: SpeciesReference

metaid_0000271
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: metaid_0000243
name: E11-RasGAP
type: Species

841478
stoichiometry: 1.0
species: metaid_0000336
type: SpeciesReference

metaid_0000373
kinetic law: 836499
modifier: 836487
product: 836475
reactant: 836463
is version of: GO:0006468
fast: false
reversible: true
name: Net E23 Phosphorylation
type: Reaction

metaid_0000292
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: metaid_0000243
name: Sum Shc
type: Species

metaid_0000332
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: metaid_0000243
name: E14-Grb2
type: Species

metaid_0000250
name: HRG-ErbB4
has part: Q15303
in compartment: metaid_0000243
has only substance units: false
has part: Q02297
type: Species
initial concentration: NaN
initial amount: 0.0
boundary condition: false
constant: false

838043
stoichiometry: 1.0
species: metaid_0000266
type: SpeciesReference

836149
stoichiometry: 1.0
species: metaid_0000252
type: SpeciesReference

metaid_0000272
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: metaid_0000243
name: E12-Grb2
type: Species

metaid_0000309
constant: false
is version of: IPR013753
type: Species
has part: P01112
in compartment: metaid_0000243
has part: CHEBI:17552
initial concentration: NaN
name: RasGDP
initial amount: 95.7
boundary condition: false
has only substance units: false

metaid_0000460
kinetic law: 842655
product: 842643
reactant: 842631
reactant: 842619
fast: false
reversible: true
name: ERKstar binding to Phosphatase
type: Reaction

metaid_0000293
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: metaid_0000243
name: Sum PI-3K
type: Species

837029
stoichiometry: 1.0
species: metaid_0000273
type: SpeciesReference

metaid_0000374
kinetic law: 836547
modifier: 836535
product: 836523
reactant: 836511
is version of: GO:0006468
fast: false
reversible: true
name: Net E34 Phosphorylation
type: Reaction

837754
stoichiometry: 1.0
species: metaid_0000294
type: SpeciesReference

837512
stoichiometry: 1.0
species: metaid_0000291
type: SpeciesReference

840621
stoichiometry: 1.0
species: metaid_0000330
type: SpeciesReference

metaid_0000178
constant: true
value: 7.0E-4
name: kon22
type: Parameter

835981
stoichiometry: 1.0
species: metaid_0000246
type: SpeciesReference

metaid_0000158
constant: true
value: 1.0606
name: kon7
type: Parameter

metaid_0000335
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: metaid_0000243
name: E14-RasGAP
type: Species

836655
stoichiometry: 1.0
species: metaid_0000257
type: SpeciesReference

metaid_0000273
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: metaid_0000243
name: E12-Shc
type: Species

836330
stoichiometry: 1.0
species: metaid_0000250
type: SpeciesReference

837091
stoichiometry: 1.0
species: metaid_0000258
type: SpeciesReference

metaid_0000294
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: metaid_0000243
name: Sum RasGAP
type: Species

837572
stoichiometry: 1.0
species: metaid_0000260
type: SpeciesReference

842486
stoichiometry: 1.0
species: metaid_0000356
type: SpeciesReference

metaid_0000308
in compartment: metaid_0000243
is described by: http://identifiers.org/omim/611223
has only substance units: false
constant: false
initial concentration: NaN
type: Species
initial amount: 444.0
name: Akt
boundary condition: false
is version of: Q9Y243

metaid_0000375
kinetic law: 836595
modifier: 836583
product: 836571
reactant: 836559
is version of: GO:0006468
fast: false
reversible: true
name: Net E24 Phosphorylation
type: Reaction

841623
stoichiometry: 1.0
species: metaid_0000247
type: SpeciesReference

metaid_0000179
constant: true
value: 0.0138
name: kon23
type: Parameter

842740
stoichiometry: 1.0
species: metaid_0000359
type: SpeciesReference

metaid_0000159
constant: true
value: 1.0259
name: kon8
type: Parameter

836245
stoichiometry: 1.0
species: metaid_0000254
type: SpeciesReference

metaid_0000334
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: metaid_0000243
name: E14-PI-3K
type: Species

metaid_0000274
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: metaid_0000243
name: E12-RasGAP
type: Species

837428
stoichiometry: 1.0
species: metaid_0000278
type: SpeciesReference

838922
stoichiometry: 1.0
species: metaid_0000291
type: SpeciesReference

842198
stoichiometry: 1.0
species: metaid_0000355
type: SpeciesReference

839163
stoichiometry: 1.0
species: metaid_0000294
type: SpeciesReference

842727
stoichiometry: 1.0
species: metaid_0000360
type: SpeciesReference

840199
stoichiometry: 1.0
species: metaid_0000323
type: SpeciesReference

841068
stoichiometry: 1.0
species: metaid_0000337
type: SpeciesReference

839223
stoichiometry: 1.0
species: metaid_0000305
type: SpeciesReference

metaid_0000023
constant: true
value: 590.5058
name: Vmaxr47
type: Parameter

838886
stoichiometry: 1.0
species: metaid_0000296
type: SpeciesReference

840174
stoichiometry: 1.0
species: metaid_0000267
type: SpeciesReference

metaid_0000439
kinetic law: 841515
product: 841503
product: 841490
reactant: 841478
reactant: 841466
fast: false
reversible: true
name: Net E14/PTP1B Binding
type: Reaction

842159
stoichiometry: 1.0
species: metaid_0000336
type: SpeciesReference

metaid_0000024
constant: true
value: 698.6022
name: Kmf47
type: Parameter

metaid_0000419
kinetic law: 840211
product: 840199
product: 840186
reactant: 840174
reactant: 840162
fast: false
reversible: true
name: SOS binding to SigG-A
type: Reaction

841116
stoichiometry: 1.0
species: metaid_0000336
type: SpeciesReference

metaid_0000438
kinetic law: 841454
product: 841442
product: 841430
reactant: 841418
reactant: 841405
fast: false
reversible: true
name: Net E13/PTP1B Binding
type: Reaction

838199
stoichiometry: 1.0
species: metaid_0000262
type: SpeciesReference

metaid_0000049
constant: true
value: 944.7692
name: Kmr53
type: Parameter

837404
stoichiometry: 1.0
species: metaid_0000259
type: SpeciesReference

metaid_0000331
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: metaid_0000243
name: E13-RasGAP
type: Species

836752
stoichiometry: 1.0
species: metaid_0000257
type: SpeciesReference

metaid_0000021
constant: true
value: 0.0259
name: kdeg
type: Parameter

metaid_0000351
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: metaid_0000243
name: Aktstar
type: Species

metaid_0000418
name: Gab1 binding to SigG-O
kinetic law: 840150
reversible: true
modifier: 840138
modifier: 840102
product: 840066
product: 840078
reactant: 840054
modifier: 840114
type: Reaction
reactant: 840042
modifier: 840090
modifier: 840126
fast: false

metaid_0000437
kinetic law: 841393
product: 841381
product: 841369
reactant: 841357
reactant: 841345
fast: false
reversible: true
name: Net E44/PTP1B Binding
type: Reaction

836691
stoichiometry: 1.0
species: metaid_0000291
type: SpeciesReference

840379
stoichiometry: 1.0
species: metaid_0000327
type: SpeciesReference

metaid_0000330
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: metaid_0000243
name: E13-PI-3K
type: Species

metaid_0000022
constant: true
value: 24.6048
name: kf47
type: Parameter

837802
stoichiometry: 1.0
species: metaid_0000263
type: SpeciesReference

842107
stoichiometry: 1.0
species: metaid_0000266
type: SpeciesReference

metaid_0000350
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: metaid_0000243
name: H_E4_p-PTP-1B
type: Species

839981
stoichiometry: 1.0
species: metaid_0000321
type: SpeciesReference

metaid_0000417
kinetic law: 840030
product: 840018
product: 840006
reactant: 839994
reactant: 839981
fast: false
reversible: true
name: SOS binding to SigA-G
type: Reaction

metaid_0000290
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: metaid_0000243
name: E44-RasGAP
type: Species

836414
stoichiometry: 1.0
species: metaid_0000252
type: SpeciesReference

838994
stoichiometry: 1.0
species: metaid_0000264
type: SpeciesReference

841043
stoichiometry: 1.0
species: metaid_0000257
type: SpeciesReference

840427
stoichiometry: 1.0
species: metaid_0000263
type: SpeciesReference

metaid_0000047
constant: true
value: 59.2314
name: Vmaxr53
type: Parameter

838320
stoichiometry: 1.0
species: metaid_0000293
type: SpeciesReference

837354
stoichiometry: 1.0
species: metaid_0000265
type: SpeciesReference

metaid_0000416
kinetic law: 839969
product: 839957
reactant: 839945
reactant: 839933
fast: false
reversible: true
name: Grb2 binding to P3_A
type: Reaction

837899
stoichiometry: 1.0
species: metaid_0000264
type: SpeciesReference

metaid_0000353
initial concentration: NaN
type: Species
is version of: http://identifiers.org/omim/131530
is version of: P01133
initial amount: 10.0
has only substance units: false
name: EGF
boundary condition: false
constant: false
in compartment: metaid_0000243

841731
stoichiometry: 1.0
species: metaid_0000350
type: SpeciesReference

metaid_0000027
constant: true
value: 715.5688
name: Kmf48
type: Parameter

841832
stoichiometry: 1.0
species: metaid_0000350
type: SpeciesReference

838103
stoichiometry: 1.0
species: metaid_0000262
type: SpeciesReference

metaid_0000048
constant: true
value: 812.254
name: Kmf53
type: Parameter

metaid_0000415
kinetic law: 839921
modifier: 839909
product: 839897
reactant: 839885
fast: false
reversible: true
name: Net Gab1 S/T Phosphorylation
type: Reaction

841080
stoichiometry: 1.0
species: metaid_0000345
type: SpeciesReference

837887
stoichiometry: 1.0
species: metaid_0000261
type: SpeciesReference

839127
stoichiometry: 1.0
species: metaid_0000297
type: SpeciesReference

metaid_0000352
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: metaid_0000243
name: SumGab1_p-PTP-1B
type: Species

841430
stoichiometry: 1.0
species: metaid_0000343
type: SpeciesReference

metaid_0000028
constant: true
value: 324.9294
name: Kmr48
type: Parameter

metaid_0000465
constant: false
boundary condition: true
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: metaid_0000243
name: normalized Erk*
type: Species

839897
stoichiometry: 1.0
species: metaid_0000319
type: SpeciesReference

840754
stoichiometry: 1.0
species: metaid_0000332
type: SpeciesReference

metaid_0000045
constant: true
value: 675.2994
name: Kmr52
type: Parameter

837440
stoichiometry: 1.0
species: metaid_0000294
type: SpeciesReference

metaid_0000414
kinetic law: 839873
modifier: 839861
product: 839849
reactant: 839837
fast: false
reversible: true
name: Net SOS S/T Phosphorylation
type: Reaction

metaid_0000025
constant: true
value: 483.8622
name: Kmr47
type: Parameter

metaid_0000355
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: metaid_0000243
name: fint
type: Species

metaid_0000468
unit: 835920
name: nanomole
type: SBMLUnitsDef

842425
stoichiometry: 1.0
species: metaid_0000316
type: SpeciesReference

841381
stoichiometry: 1.0
species: metaid_0000345
type: SpeciesReference

metaid_0000046
constant: true
value: 0.6094
name: kf53
type: Parameter

metaid_0000413
kinetic law: 839825
modifier: 839813
product: 839801
reactant: 839789
fast: false
reversible: true
name: Net MEK Activation
type: Reaction

837283
stoichiometry: 1.0
species: metaid_0000276
type: SpeciesReference

836378
stoichiometry: 1.0
species: metaid_0000257
type: SpeciesReference

metaid_0000026
constant: true
value: 16.833
name: kf48
type: Parameter

metaid_0000354
type: Species
initial amount: 10.0
initial concentration: NaN
has only substance units: false
constant: false
is version of: http://identifiers.org/omim/142445
name: HRG
boundary condition: false
is version of: Q02297
in compartment: metaid_0000243

metaid_0000131
constant: true
value: 485.2626
name: Kmf81
type: Parameter

836837
stoichiometry: 1.0
species: metaid_0000257
type: SpeciesReference

metaid_0000182
constant: true
value: 0.0137
name: kon75
type: Parameter

839319
stoichiometry: 1.0
species: metaid_0000308
type: SpeciesReference

metaid_0000111
constant: true
value: 11.4211
name: kPTP12
type: Parameter

metaid_0000030
constant: true
value: 44.3501
name: kf49
type: Parameter

841284
stoichiometry: 1.0
species: metaid_0000261
type: SpeciesReference

metaid_0000430
kinetic law: 840959
product: 840947
product: 840935
reactant: 840923
reactant: 840911
fast: false
reversible: true
name: Net E14/PI3K Binding
type: Reaction

840681
stoichiometry: 1.0
species: metaid_0000331
type: SpeciesReference

metaid_0000070
constant: true
value: 8.0557
name: koff7
type: Parameter

837923
stoichiometry: 1.0
species: metaid_0000292
type: SpeciesReference

metaid_0000183
constant: true
value: 0.0355
name: kon26
type: Parameter

838742
stoichiometry: 1.0
species: metaid_0000323
type: SpeciesReference

metaid_0000130
constant: true
value: 242.6034
name: Vmaxr81
type: Parameter

842042
stoichiometry: 1.0
species: metaid_0000292
type: SpeciesReference

metaid_0000110
constant: true
value: 78.204
name: kPTP11
type: Parameter

836475
stoichiometry: 1.0
species: metaid_0000259
type: SpeciesReference

metaid_0000410
name: Net RasGTP Production
type: Reaction
kinetic law: 839583
reversible: true
fast: false
modifier: 839559
modifier: 839547
reactant: 839523
modifier: 839571
product: 839535

842315
stoichiometry: 1.0
species: metaid_0000354
type: SpeciesReference

metaid_0000133
constant: true
value: 6.9987
name: kf82
type: Parameter

metaid_0000431
reactant: 840983
product: 841007
reactant: 840971
type: Reaction
kinetic law: 841031
name: Net E14/RasGAP Binding
reversible: true
fast: false
product: 840995
modifier: 841019

839933
stoichiometry: 1.0
species: metaid_0000263
type: SpeciesReference

839849
stoichiometry: 1.0
species: metaid_0000318
type: SpeciesReference

metaid_0000184
constant: true
value: 0.0201
name: kon27
type: Parameter

metaid_0000071
constant: true
value: 9.1034
name: koff8
type: Parameter

metaid_0000032
constant: true
value: 343.2483
name: Kmf49
type: Parameter

841224
stoichiometry: 1.0
species: metaid_0000260
type: SpeciesReference

metaid_0000113
constant: true
value: 57.7506
name: kPTP14
type: Parameter

metaid_0000411
modifier: 839667
product: 839607
reactant: 839595
modifier: 839716
modifier: 839643
kinetic law: 839728
name: Net RasGAP Phosphorylation
fast: false
modifier: 839619
modifier: 839655
modifier: 839679
modifier: 839691
modifier: 839704
type: Reaction
modifier: 839631
reversible: true

metaid_0000432
kinetic law: 841092
product: 841080
product: 841068
reactant: 841056
reactant: 841043
fast: false
reversible: true
name: Net E11/PTP1B Binding
type: Reaction

metaid_0000132
constant: true
value: 323.4012
name: Kmr81
type: Parameter

837983
stoichiometry: 1.0
species: metaid_0000265
type: SpeciesReference

metaid_0000185
constant: true
value: 0.0074
name: kon28
type: Parameter

metaid_0000072
constant: true
value: 5.5425
name: koff9
type: Parameter

838368
stoichiometry: 1.0
species: metaid_0000290
type: SpeciesReference

840729
stoichiometry: 1.0
species: metaid_0000327
type: SpeciesReference

841899
stoichiometry: 1.0
species: metaid_0000352
type: SpeciesReference

840066
stoichiometry: 1.0
species: metaid_0000320
type: SpeciesReference

metaid_0000412
kinetic law: 839777
modifier: 839764
product: 839752
reactant: 839740
fast: false
reversible: true
name: Net Raf Activation
type: Reaction

metaid_0000031
constant: true
value: 552.6746
name: kr49
type: Parameter

metaid_0000112
constant: true
value: 55.2104
name: kPTP13
type: Parameter

837175
stoichiometry: 1.0
species: metaid_0000263
type: SpeciesReference

840838
stoichiometry: 1.0
species: metaid_0000264
type: SpeciesReference

841176
stoichiometry: 1.0
species: metaid_0000336
type: SpeciesReference

835945
stoichiometry: 1.0
species: metaid_0000248
type: SpeciesReference

839079
stoichiometry: 1.0
species: metaid_0000265
type: SpeciesReference

metaid_0000186
constant: true
value: 0.0346
name: kon29
type: Parameter

metaid_0000433
kinetic law: 841152
product: 841140
product: 841128
reactant: 841116
reactant: 841104
fast: false
reversible: true
name: Net E12/PTP1B Binding
type: Reaction

metaid_0000248
type: Species
constant: false
initial amount: 0.0
has part: P01133
has part: P00533
has only substance units: false
name: EGF-ErbB1
boundary condition: false
initial concentration: NaN
in compartment: metaid_0000243

metaid_0000135
constant: true
value: 781.4374
name: Kmf82
type: Parameter

838429
stoichiometry: 1.0
species: metaid_0000296
type: SpeciesReference

841490
stoichiometry: 1.0
species: metaid_0000344
type: SpeciesReference

841539
stoichiometry: 1.0
species: metaid_0000346
type: SpeciesReference

metaid_0000220
constant: true
value: 0.0045
name: kon68
type: Parameter

metaid_0000187
constant: true
value: 0.0053
name: kon76
type: Parameter

metaid_0000134
constant: true
value: 398.1931
name: Vmaxr82
type: Parameter

840923
stoichiometry: 1.0
species: metaid_0000265
type: SpeciesReference

metaid_0000434
kinetic law: 841212
product: 841200
product: 841188
reactant: 841176
reactant: 841164
fast: false
reversible: true
name: Net E23/PTP1B Binding
type: Reaction

metaid_0000247
is version of: Q15303
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 399.0
in compartment: metaid_0000243
name: ErbB4
type: Species

841260
stoichiometry: 1.0
species: metaid_0000345
type: SpeciesReference

838766
stoichiometry: 1.0
species: metaid_0000291
type: SpeciesReference

841200
stoichiometry: 1.0
species: metaid_0000345
type: SpeciesReference

metaid_0000221
constant: true
value: 0.0084
name: kon69
type: Parameter

836185
stoichiometry: 1.0
species: metaid_0000245
type: SpeciesReference

837814
stoichiometry: 1.0
species: metaid_0000283
type: SpeciesReference

metaid_0000435
kinetic law: 841272
product: 841260
product: 841248
reactant: 841236
reactant: 841224
fast: false
reversible: true
name: Net E34/PTP1B Binding
type: Reaction

metaid_0000137
constant: true
value: 1.7628
name: kf83
type: Parameter

metaid_0000188
constant: true
value: 0.002
name: kon30
type: Parameter

842643
stoichiometry: 1.0
species: metaid_0000361
type: SpeciesReference

836559
stoichiometry: 1.0
species: metaid_0000255
type: SpeciesReference

841912
stoichiometry: 1.0
species: metaid_0000345
type: SpeciesReference

840983
stoichiometry: 1.0
species: metaid_0000266
type: SpeciesReference

metaid_0000449
kinetic law: 842016
product: 842003
reactant: 841990
reactant: 841977
fast: false
reversible: false
name: E11G Degradation
type: Reaction

837476
stoichiometry: 1.0
species: metaid_0000260
type: SpeciesReference

metaid_0000222
constant: true
value: 3.97
name: koff69
type: Parameter

metaid_0000136
constant: true
value: 595.8395
name: Kmr82
type: Parameter

metaid_0000189
constant: true
value: 0.0032
name: kon31
type: Parameter

841007
stoichiometry: 1.0
species: metaid_0000294
type: SpeciesReference

840283
stoichiometry: 1.0
species: metaid_0000248
type: SpeciesReference

metaid_0000249
constant: false
initial amount: 0.0
has only substance units: false
name: HRG-ErbB3
type: Species
boundary condition: false
has part: P21860
initial concentration: NaN
in compartment: metaid_0000243
has part: Q02297

metaid_0000436
kinetic law: 841333
product: 841321
product: 841309
reactant: 841297
reactant: 841284
fast: false
reversible: true
name: Net E24/PTP1B Binding
type: Reaction

837115
stoichiometry: 1.0
species: metaid_0000274
type: SpeciesReference

838344
stoichiometry: 1.0
species: metaid_0000262
type: SpeciesReference

838031
stoichiometry: 1.0
species: metaid_0000261
type: SpeciesReference

metaid_0000203
constant: true
value: 0.0191
name: kon40
type: Parameter

metaid_0000264
constant: false
is described by: http://identifiers.org/omim/605217
has only substance units: false
type: Species
name: Shc
boundary condition: false
initial amount: 11.5
is version of: P98077
in compartment: metaid_0000243
initial concentration: NaN

metaid_0000139
constant: true
value: 609.4766
name: Kmf83
type: Parameter

metaid_0000119
constant: true
value: 1.4323
name: koff75
type: Parameter

metaid_0000244
is version of: P00533
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 274.0
in compartment: metaid_0000243
name: ErbB1
type: Species

metaid_0000077
constant: true
value: 2.3361
name: koff19
type: Parameter

metaid_0000163
constant: true
value: 0.3721
name: kf11
type: Parameter

842094
stoichiometry: 1.0
species: metaid_0000294
type: SpeciesReference

metaid_0000223
constant: true
value: 0.0116
name: kon70
type: Parameter

840947
stoichiometry: 1.0
species: metaid_0000293
type: SpeciesReference

metaid_0000050
constant: true
value: 0.0538
name: kf54
type: Parameter

metaid_0000204
constant: true
value: 0.0051
name: kon41
type: Parameter

metaid_0000289
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: metaid_0000243
name: E44-PI-3K
type: Species

840669
stoichiometry: 1.0
species: metaid_0000266
type: SpeciesReference

metaid_0000263
initial amount: 82.4
is version of: P62993
boundary condition: false
constant: false
has only substance units: false
in compartment: metaid_0000243
type: Species
initial concentration: NaN
is described by: http://identifiers.org/omim/108355
name: Grb2

837682
stoichiometry: 1.0
species: metaid_0000281
type: SpeciesReference

metaid_0000118
constant: true
value: 1.2496
name: koff74
type: Parameter

metaid_0000243
is: GO:0005886
constant: true
size: 1.0
spatial dimensions: 2.0
name: membrane
type: Compartment

metaid_0000078
constant: true
value: 0.6761
name: koff20
type: Parameter

metaid_0000162
constant: true
value: 0.6496
name: kf10
type: Parameter

metaid_0000138
constant: true
value: 534.0531
name: Vmaxr83
type: Parameter

metaid_0000224
constant: true
value: 2.6069
name: koff70
type: Parameter

837005
stoichiometry: 1.0
species: metaid_0000258
type: SpeciesReference

metaid_0000051
constant: true
value: 588.2671
name: Vmaxr54
type: Parameter

838574
stoichiometry: 1.0
species: metaid_0000297
type: SpeciesReference

838236
stoichiometry: 1.0
species: metaid_0000292
type: SpeciesReference

838802
stoichiometry: 1.0
species: metaid_0000295
type: SpeciesReference

metaid_0000288
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: metaid_0000243
name: E44-Shc
type: Species

842595
stoichiometry: 1.0
species: metaid_0000315
type: SpeciesReference

840513
stoichiometry: 1.0
species: metaid_0000326
type: SpeciesReference

metaid_0000266
initial concentration: NaN
is version of: IPR001936
is version of: P20936
type: Species
has only substance units: false
boundary condition: false
initial amount: 93.6
is described by: http://identifiers.org/omim/139150
constant: false
name: RasGAP
in compartment: metaid_0000243

metaid_0000246
is version of: P21860
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 294.0
in compartment: metaid_0000243
name: ErbB3
type: Species

841872
stoichiometry: 1.0
species: metaid_0000297
type: SpeciesReference

metaid_0000079
constant: true
value: 4.7291
name: koff21
type: Parameter

839752
stoichiometry: 1.0
species: metaid_0000313
type: SpeciesReference

835920
exponent: 1.0
scale: -9
multipler: 1.0
kind: MOLE
type: SBMLUnit

837584
stoichiometry: 1.0
species: metaid_0000264
type: SpeciesReference

metaid_0000225
constant: true
value: 0.0078
name: kon71
type: Parameter

837041
stoichiometry: 1.0
species: metaid_0000292
type: SpeciesReference

metaid_0000205
constant: true
value: 0.0023
name: kon42
type: Parameter

metaid_0000165
constant: true
value: 0.8875
name: kf13
type: Parameter

841357
stoichiometry: 1.0
species: metaid_0000336
type: SpeciesReference

842029
stoichiometry: 1.0
species: metaid_0000270
type: SpeciesReference

metaid_0000052
constant: true
value: 457.9645
name: Kmf54
type: Parameter

metaid_0000287
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: metaid_0000243
name: E44-Grb2
type: Species

840006
stoichiometry: 1.0
species: metaid_0000322
type: SpeciesReference

metaid_0000265
constant: false
name: PI-3K
has version: P42336
boundary condition: false
has version: Q8WYR1
type: Species
in compartment: metaid_0000243
initial amount: 46.4
initial concentration: NaN
has only substance units: false

839801
stoichiometry: 1.0
species: metaid_0000315
type: SpeciesReference

metaid_0000245
is version of: P04626
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 158.0
in compartment: metaid_0000243
name: ErbB2
type: Species

metaid_0000226
constant: true
value: 2.2988
name: koff71
type: Parameter

842571
stoichiometry: 1.0
species: metaid_0000358
type: SpeciesReference

842667
stoichiometry: 1.0
species: metaid_0000361
type: SpeciesReference

metaid_0000164
constant: true
value: 1.8012
name: kf12
type: Parameter

metaid_0000206
constant: true
value: 0.0127
name: kon43
type: Parameter

metaid_0000300
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: metaid_0000243
name: Sum Shc_p-Grb2
type: Species

metaid_0000115
constant: true
value: 7.4766
name: kPTP63
type: Parameter

metaid_0000268
is version of: Q13480
constant: false
has only substance units: false
initial concentration: NaN
boundary condition: false
name: Gab1
type: Species
in compartment: metaid_0000243
is described by: http://identifiers.org/omim/604439
initial amount: 43.1

metaid_0000227
constant: true
value: 0.0355
name: kon72
type: Parameter

metaid_0000053
constant: true
value: 336.183
name: Kmr54
type: Parameter

metaid_0000383
modifier: 837235
reactant: 837163
modifier: 837223
kinetic law: 837247
product: 837199
reversible: true
type: Reaction
modifier: 837211
reactant: 837175
fast: false
name: Net E23P/Grb2 binding
product: 837187

metaid_0000318
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: metaid_0000243
name: SOS_p
type: Species

841938
stoichiometry: 1.0
species: metaid_0000257
type: SpeciesReference

metaid_0000073
constant: true
value: 0.4526
name: koff57
type: Parameter

metaid_0000240
constant: true
value: 100.0023
name: koff95
type: Parameter

metaid_0000054
constant: true
value: 0.2256
name: kf55
type: Parameter

metaid_0000114
constant: true
value: 60.2628
name: kPTP15
type: Parameter

metaid_0000301
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: metaid_0000243
name: Sum Gab1_p-Shc
type: Species

metaid_0000267
initial concentration: NaN
boundary condition: false
name: SOS
is described by: http://identifiers.org/omim/182530
constant: false
has only substance units: false
initial amount: 82.3
in compartment: metaid_0000243
is version of: Q07889
type: Species

metaid_0000200
constant: true
value: 1.9264E-4
name: kon66
type: Parameter

839607
stoichiometry: 1.0
species: metaid_0000311
type: SpeciesReference

metaid_0000228
constant: true
value: 0.907
name: koff72
type: Parameter

metaid_0000382
name: Net E12P/RasGAP binding
product: 837127
reactant: 837103
fast: false
product: 837115
reactant: 837091
modifier: 837139
kinetic law: 837151
reversible: true
type: Reaction

841405
stoichiometry: 1.0
species: metaid_0000326
type: SpeciesReference

836077
stoichiometry: 1.0
species: metaid_0000248
type: SpeciesReference

metaid_0000074
constant: true
value: 0.5737
name: koff16
type: Parameter

metaid_0000319
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: metaid_0000243
name: Gab1_p
type: Species

837790
stoichiometry: 1.0
species: metaid_0000261
type: SpeciesReference

metaid_0000302
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: metaid_0000243
name: Sum Gab1_p-PI-3K
type: Species

metaid_0000141
constant: true
value: 4.6894
name: kf84
type: Parameter

metaid_0000055
constant: true
value: 646.9003
name: Vmaxr55
type: Parameter

842776
stoichiometry: 1.0
species: metaid_0000316
type: SpeciesReference

metaid_0000201
constant: true
value: 6.6667E-5
name: kon67
type: Parameter

metaid_0000381
modifier: 837066
product: 837041
modifier: 837054
reversible: true
reactant: 837005
product: 837029
type: Reaction
fast: false
reactant: 837017
kinetic law: 837079
name: Net E12P/Shc binding

837199
stoichiometry: 1.0
species: metaid_0000291
type: SpeciesReference

836511
stoichiometry: 1.0
species: metaid_0000254
type: SpeciesReference

metaid_0000229
constant: true
value: 1.0E-16
name: eps
type: Parameter

838212
stoichiometry: 1.0
species: metaid_0000264
type: SpeciesReference

metaid_0000075
constant: true
value: 4.6874
name: koff17
type: Parameter

840850
stoichiometry: 1.0
species: metaid_0000333
type: SpeciesReference

metaid_0000316
in compartment: metaid_0000243
initial concentration: NaN
boundary condition: false
is version of: P28482
is described by: http://identifiers.org/omim/176948
name: ERK
constant: false
has only substance units: false
initial amount: 750.0
type: Species

metaid_0000180
constant: true
value: 0.005
name: kon24
type: Parameter

metaid_0000161
constant: true
value: 0.0039
name: kon57
type: Parameter

metaid_0000242
constant: true
value: 35.005
name: ERKPpase_Abund
type: Parameter

839523
stoichiometry: 1.0
species: metaid_0000309
type: SpeciesReference

metaid_0000117
constant: true
value: 3.0048
name: koff73
type: Parameter

metaid_0000140
constant: true
value: 653.5184
name: Kmr83
type: Parameter

842237
stoichiometry: 1.0
species: metaid_0000304
type: SpeciesReference

metaid_0000269
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: metaid_0000243
name: E11-Grb2
type: Species

metaid_0000303
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: metaid_0000243
name: Sum Gab1_p-RasGAP
type: Species

836788
stoichiometry: 1.0
species: metaid_0000292
type: SpeciesReference

metaid_0000116
constant: true
value: 48.6335
name: kPTP64
type: Parameter

metaid_0000056
constant: true
value: 460.9446
name: Kmf55
type: Parameter

838790
stoichiometry: 1.0
species: metaid_0000299
type: SpeciesReference

metaid_0000380
type: Reaction
kinetic law: 836993
reactant: 836909
product: 836933
modifier: 836969
name: Net E12P/Grb2 binding
fast: false
reactant: 836921
modifier: 836957
modifier: 836981
reversible: true
product: 836945

metaid_0000202
constant: true
value: 2.0E-4
name: kon80
type: Parameter

839957
stoichiometry: 1.0
species: metaid_0000321
type: SpeciesReference

metaid_0000181
constant: true
value: 0.0995
name: kon25
type: Parameter

metaid_0000317
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: metaid_0000243
name: ERK*
type: Species

metaid_0000160
constant: true
value: 2.2868
name: kon9
type: Parameter

metaid_0000076
constant: true
value: 2.2768
name: koff18
type: Parameter

metaid_0000241
constant: true
value: 19.9851
name: kcat96
type: Parameter

metaid_0000366
kinetic law: 836161
product: 836149
reactant: 836137
reactant: 836125
is version of: GO:0046983
fast: false
reversible: true
name: ErbB1/ErbB2 Heterodimerization
type: Reaction

839007
stoichiometry: 1.0
species: metaid_0000301
type: SpeciesReference

metaid_0000017
constant: true
value: 772.0
name: MEK_Abund
type: Parameter

metaid_0000347
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: metaid_0000243
name: E2_p-PTP-1B
type: Species

metaid_0000006
constant: true
value: 399.0
name: ErbB4_Abund
type: Parameter

836873
stoichiometry: 1.0
species: metaid_0000294
type: SpeciesReference

metaid_0000452
kinetic law: 842172
product: 842159
reactant: 842146
reactant: 842133
fast: false
reversible: false
name: E11T Degradation
type: Reaction

metaid_0000327
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: metaid_0000243
name: ErbB1-ErbB3_p
type: Species

metaid_0000142
constant: true
value: 634.1626
name: Vmaxr84
type: Parameter

metaid_0000281
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: metaid_0000243
name: E34-PI-3K
type: Species

metaid_0000058
constant: true
value: 279.9929
name: kf38
type: Parameter

840657
stoichiometry: 1.0
species: metaid_0000326
type: SpeciesReference

836921
stoichiometry: 1.0
species: metaid_0000263
type: SpeciesReference

841671
stoichiometry: 1.0
species: metaid_0000248
type: SpeciesReference

metaid_0000386
fast: false
product: 837440
modifier: 837452
reversible: true
kinetic law: 837464
reactant: 837416
reactant: 837404
type: Reaction
product: 837428
name: Net E23P/RasGAP binding

metaid_0000367
kinetic law: 836209
product: 836197
reactant: 836185
reactant: 836173
is version of: GO:0046983
fast: false
reversible: true
name: ErbB2/ErbB3 Heterodimerization
type: Reaction

metaid_0000346
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: metaid_0000243
name: E1_p-PTP-1B
type: Species

metaid_0000099
constant: true
value: 3.1051
name: koff40
type: Parameter

metaid_0000451
kinetic law: 842120
product: 842107
reactant: 842094
reactant: 842081
fast: false
reversible: false
name: E11R Degradation
type: Reaction

842547
stoichiometry: 1.0
species: metaid_0000358
type: SpeciesReference

metaid_0000326
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: metaid_0000243
name: ErbB1-ErbB3_p
type: Species

metaid_0000005
constant: true
value: 294.0
name: ErbB3_Abund
type: Parameter

metaid_0000018
constant: true
value: 749.9716
name: ERK_Abund
type: Parameter

metaid_0000219
constant: true
value: 5.5142
name: koff62
type: Parameter

metaid_0000143
constant: true
value: 622.3847
name: Kmf84
type: Parameter

metaid_0000282
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: metaid_0000243
name: E34-RasGAP
type: Species

metaid_0000387
modifier: 837536
product: 837512
reversible: true
modifier: 837524
fast: false
name: Net E34P/Grb2 binding
kinetic law: 837560
modifier: 837548
type: Reaction
product: 837500
reactant: 837488
reactant: 837476

metaid_0000057
constant: true
value: 643.9247
name: Kmr55
type: Parameter

842081
stoichiometry: 1.0
species: metaid_0000271
type: SpeciesReference

metaid_0000364
kinetic law: 836065
modifier: 836053
product: 836041
reactant: 836029
fast: false
reversible: true
name: HRG Binding to ErbB4
type: Reaction

842450
stoichiometry: 1.0
species: metaid_0000357
type: SpeciesReference

839885
stoichiometry: 1.0
species: metaid_0000268
type: SpeciesReference

metaid_0000450
kinetic law: 842068
product: 842055
reactant: 842042
reactant: 842029
fast: false
reversible: false
name: E11S Degradation
type: Reaction

metaid_0000098
constant: true
value: 1.6142
name: koff67
type: Parameter

837367
stoichiometry: 1.0
species: metaid_0000277
type: SpeciesReference

metaid_0000345
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: metaid_0000243
name: Sig-PTP-1B
type: Species

837294
stoichiometry: 1.0
species: metaid_0000292
type: SpeciesReference

836282
stoichiometry: 1.0
species: metaid_0000245
type: SpeciesReference

metaid_0000144
constant: true
value: 258.4637
name: Kmr84
type: Parameter

metaid_0000019
constant: true
value: 223.8776
name: VmaxPY
type: Parameter

metaid_0000325
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: metaid_0000243
name: ErbB1-ErbB4
type: Species

840235
stoichiometry: 1.0
species: metaid_0000248
type: SpeciesReference

metaid_0000008
constant: true
value: 11.5
name: Shc_Abund
type: Parameter

838139
stoichiometry: 1.0
species: metaid_0000291
type: SpeciesReference

metaid_0000384
modifier: 837318
type: Reaction
fast: false
modifier: 837306
kinetic law: 837330
name: Net E23P/Shc binding
reactant: 837259
reversible: true
product: 837283
reactant: 837271
product: 837294

840741
stoichiometry: 1.0
species: metaid_0000263
type: SpeciesReference

842003
stoichiometry: 1.0
species: metaid_0000263
type: SpeciesReference

836137
stoichiometry: 1.0
species: metaid_0000245
type: SpeciesReference

metaid_0000365
kinetic law: 836113
product: 836101
reactant: 836089
reactant: 836077
is version of: GO:0046983
fast: false
reversible: true
name: ErbB1 Dimerization
type: Reaction

metaid_0000097
constant: true
value: 2.2988
name: koff66
type: Parameter

841575
stoichiometry: 1.0
species: metaid_0000245
type: SpeciesReference

842691
stoichiometry: 1.0
species: metaid_0000360
type: SpeciesReference

metaid_0000344
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: metaid_0000243
name: E14-PTP-1B
type: Species

metaid_0000145
constant: true
value: 6.7591
name: kf85
type: Parameter

metaid_0000007
constant: true
value: 82.4
name: Grb2_Abund
type: Parameter

metaid_0000324
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: metaid_0000243
name: ErbB1-ErbB3
type: Species

840549
stoichiometry: 1.0
species: metaid_0000292
type: SpeciesReference

metaid_0000280
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: metaid_0000243
name: E34-Shc
type: Species

metaid_0000385
kinetic law: 837392
product: 837379
product: 837367
reactant: 837354
reactant: 837342
fast: false
reversible: true
name: Net E23P/PI3K binding
type: Reaction

837017
stoichiometry: 1.0
species: metaid_0000264
type: SpeciesReference

metaid_0000059
constant: true
value: 385.7428
name: kf39
type: Parameter

841977
stoichiometry: 1.0
species: metaid_0000269
type: SpeciesReference

840633
stoichiometry: 1.0
species: metaid_0000293
type: SpeciesReference

835993
stoichiometry: 1.0
species: metaid_0000249
type: SpeciesReference

837500
stoichiometry: 1.0
species: metaid_0000279
type: SpeciesReference

metaid_0000166
constant: true
value: 6.1726
name: kf14
type: Parameter

836945
stoichiometry: 1.0
species: metaid_0000291
type: SpeciesReference

836089
stoichiometry: 1.0
species: metaid_0000248
type: SpeciesReference

837742
stoichiometry: 1.0
species: metaid_0000282
type: SpeciesReference

metaid_0000362
kinetic law: 835969
modifier: 835957
product: 835945
reactant: 835932
is version of: GO:0006461
fast: false
reversible: true
name: EGF Binding to ErbB1
type: Reaction

836667
stoichiometry: 1.0
species: metaid_0000263
type: SpeciesReference

836909
stoichiometry: 1.0
species: metaid_0000258
type: SpeciesReference

metaid_0000146
constant: true
value: 369.2261
name: Vmaxr85
type: Parameter

metaid_0000323
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: metaid_0000243
name: Sum SOS
type: Species

metaid_0000285
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: metaid_0000243
name: E24-PI-3K
type: Species

839091
stoichiometry: 1.0
species: metaid_0000302
type: SpeciesReference

metaid_0000167
constant: true
value: 1.3565
name: kf15
type: Parameter

841951
stoichiometry: 1.0
species: metaid_0000304
type: SpeciesReference

metaid_0000409
reversible: true
modifier: 839475
product: 839379
modifier: 839415
modifier: 839439
modifier: 839391
fast: false
modifier: 839487
type: Reaction
modifier: 839403
modifier: 839463
reactant: 839367
modifier: 839427
kinetic law: 839511
name: Net PIP3 Production
modifier: 839499
modifier: 839451

842474
stoichiometry: 1.0
species: metaid_0000357
type: SpeciesReference

metaid_0000363
kinetic law: 836017
modifier: 836005
product: 835993
reactant: 835981
fast: false
reversible: true
name: HRG Binding to ErbB3
type: Reaction

841635
stoichiometry: 1.0
species: metaid_0000348
type: SpeciesReference

837416
stoichiometry: 1.0
species: metaid_0000266
type: SpeciesReference

metaid_0000260
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: metaid_0000243
name: E34_p
type: Species

metaid_0000322
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: metaid_0000243
name: Sum PIP3-Gab1-Grb2_SOS
type: Species

metaid_0000009
constant: true
value: 46.4
name: PI3K_Abund
type: Parameter

836233
stoichiometry: 1.0
species: metaid_0000250
type: SpeciesReference

metaid_0000147
constant: true
value: 179.6486
name: Kmf85
type: Parameter

839367
stoichiometry: 1.0
species: metaid_0000306
type: SpeciesReference

metaid_0000286
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: metaid_0000243
name: E24-RasGAP
type: Species

838284
stoichiometry: 1.0
species: metaid_0000262
type: SpeciesReference

metaid_0000168
constant: true
value: 0.9297
name: kf63
type: Parameter

metaid_0000360
is version of: P28562
name: ERKpase
initial amount: 0.0
is described by: http://identifiers.org/omim/602747
boundary condition: false
constant: false
has only substance units: false
is version of: Q16828
is described by: http://identifiers.org/omim/600714
in compartment: metaid_0000243
is version of: Q13115
initial concentration: NaN
is described by: http://identifiers.org/omim/602748
type: Species

838706
stoichiometry: 1.0
species: metaid_0000291
type: SpeciesReference

metaid_0000388
reversible: true
name: Net E34P/Shc binding
reactant: 837572
fast: false
modifier: 837634
kinetic law: 837646
modifier: 837621
product: 837609
reactant: 837584
product: 837597
type: Reaction

841466
stoichiometry: 1.0
species: metaid_0000327
type: SpeciesReference

metaid_0000283
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: metaid_0000243
name: E24-Grb2
type: Species

metaid_0000349
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: metaid_0000243
name: E_E1_p-PTP-1B
type: Species

metaid_0000321
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: metaid_0000243
name: Sum PIP3-Gab1-Grb2
type: Species

metaid_0000148
constant: true
value: 290.7667
name: Kmr85
type: Parameter

metaid_0000261
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: metaid_0000243
name: E24_p
type: Species

metaid_0000361
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 35.0
in compartment: metaid_0000243
name: ERK*-ERKpase
type: Species

metaid_0000169
constant: true
value: 1.2083
name: kf64
type: Parameter

836607
stoichiometry: 1.0
species: metaid_0000256
type: SpeciesReference

metaid_0000284
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: metaid_0000243
name: E24-Shc
type: Species

metaid_0000389
kinetic law: 837706
product: 837694
product: 837682
reactant: 837670
reactant: 837658
fast: false
reversible: true
name: Net E34P/PI3K binding
type: Reaction

metaid_0000320
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: metaid_0000243
name: Gab1_SumGrb2-SOS
type: Species

metaid_0000348
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: metaid_0000243
name: E4_p-PTP-1B
type: Species

metaid_0000262
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: metaid_0000243
name: E44_p
type: Species

metaid_0000149
constant: true
value: 9.9783
name: kcon49
type: Parameter

838055
stoichiometry: 1.0
species: metaid_0000286
type: SpeciesReference

metaid_0000037
constant: true
value: 0.0
name: kr51
type: Parameter

838910
stoichiometry: 1.0
species: metaid_0000300
type: SpeciesReference

841128
stoichiometry: 1.0
species: metaid_0000338
type: SpeciesReference

metaid_0000426
kinetic law: 840645
product: 840633
product: 840621
reactant: 840609
reactant: 840597
fast: false
reversible: true
name: Net E13/PI3K Binding
type: Reaction

metaid_0000406
reversible: true
product: 839163
reactant: 839139
modifier: 839175
fast: false
type: Reaction
name: Net Gab1/RasGAP binding
product: 839151
reactant: 839127
kinetic law: 839187

metaid_0000092
constant: true
value: 3.2036
name: koff34
type: Parameter

842498
stoichiometry: 1.0
species: metaid_0000315
type: SpeciesReference

metaid_0000038
constant: true
value: 16.737
name: Vmaxr51
type: Parameter

836342
stoichiometry: 1.0
species: metaid_0000256
type: SpeciesReference

metaid_0000459
kinetic law: 842607
product: 842595
product: 842583
reactant: 842571
fast: false
reversible: false
name: ERKstar production
type: Reaction

metaid_0000425
type: Reaction
name: Net E13/Shc Binding
product: 840537
reactant: 840525
modifier: 840573
kinetic law: 840585
reactant: 840513
fast: false
reversible: true
modifier: 840561
product: 840549

838561
stoichiometry: 1.0
species: metaid_0000295
type: SpeciesReference

metaid_0000405
kinetic law: 839115
product: 839103
product: 839091
reactant: 839079
reactant: 839067
fast: false
reversible: true
name: Net Gab1/PI3K binding
type: Reaction

838007
stoichiometry: 1.0
species: metaid_0000293
type: SpeciesReference

metaid_0000091
constant: true
value: 1.2817
name: koff33
type: Parameter

837259
stoichiometry: 1.0
species: metaid_0000259
type: SpeciesReference

metaid_0000010
constant: true
value: 93.6
name: RasGAP_Abund
type: Parameter

metaid_0000458
kinetic law: 842559
product: 842547
reactant: 842534
reactant: 842522
fast: false
reversible: true
name: ERK binding to MEKstar
type: Reaction

842146
stoichiometry: 1.0
species: metaid_0000345
type: SpeciesReference

841104
stoichiometry: 1.0
species: metaid_0000258
type: SpeciesReference

841056
stoichiometry: 1.0
species: metaid_0000336
type: SpeciesReference

metaid_0000039
constant: true
value: 599.7076
name: Kmf51
type: Parameter

841767
stoichiometry: 1.0
species: metaid_0000346
type: SpeciesReference

metaid_0000428
product: 840754
name: Net E14/Grb2 Binding
reactant: 840741
modifier: 840790
reversible: true
modifier: 840778
reactant: 840729
type: Reaction
modifier: 840802
fast: false
kinetic law: 840814
product: 840766

839151
stoichiometry: 1.0
species: metaid_0000303
type: SpeciesReference

842715
stoichiometry: 1.0
species: metaid_0000356
type: SpeciesReference

metaid_0000090
constant: true
value: 3.8752
name: koff32
type: Parameter

metaid_0000408
kinetic law: 839355
modifier: 839343
product: 839331
reactant: 839319
fast: false
reversible: true
name: Net Akt Activation
type: Reaction

840162
stoichiometry: 1.0
species: metaid_0000299
type: SpeciesReference

metaid_0000011
constant: true
value: 82.3
name: SOS_Abund
type: Parameter

839235
stoichiometry: 1.0
species: metaid_0000295
type: SpeciesReference

840415
stoichiometry: 1.0
species: metaid_0000326
type: SpeciesReference

841719
stoichiometry: 1.0
species: metaid_0000250
type: SpeciesReference

841442
stoichiometry: 1.0
species: metaid_0000345
type: SpeciesReference

840186
stoichiometry: 1.0
species: metaid_0000320
type: SpeciesReference

metaid_0000427
reactant: 840657
type: Reaction
modifier: 840705
product: 840681
fast: false
kinetic law: 840717
reversible: true
name: Net E13/RasGAP Binding
product: 840693
reactant: 840669

839139
stoichiometry: 1.0
species: metaid_0000266
type: SpeciesReference

842185
stoichiometry: 1.0
species: metaid_0000304
type: SpeciesReference

metaid_0000407
modifier: 839247
modifier: 839295
kinetic law: 839307
fast: false
type: Reaction
reactant: 839211
modifier: 839259
name: Net Gab1/PIP3 binding
modifier: 839271
reactant: 839199
modifier: 839283
product: 839223
product: 839235
reversible: true

metaid_0000012
constant: true
value: 43.1
name: Gab1_Abund
type: Parameter

metaid_0000457
kinetic law: 842510
product: 842498
product: 842486
reactant: 842474
fast: false
reversible: false
name: pERK production
type: Reaction

metaid_0000402
modifier: 838862
reactant: 838778
product: 838802
modifier: 838814
product: 838790
modifier: 838850
reactant: 838766
reversible: true
type: Reaction
modifier: 838826
fast: false
kinetic law: 838874
modifier: 838838
name: Net Grb2/Gab1 binding

840766
stoichiometry: 1.0
species: metaid_0000291
type: SpeciesReference

metaid_0000033
constant: true
value: 753.1667
name: Kmr49
type: Parameter

metaid_0000456
kinetic law: 842462
product: 842450
reactant: 842438
reactant: 842425
fast: false
reversible: true
name: ERK binding to MEKstar
type: Reaction

836764
stoichiometry: 1.0
species: metaid_0000264
type: SpeciesReference

metaid_0000343
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: metaid_0000243
name: E13-PTP-1B
type: Species

metaid_0000013
constant: true
value: 197.0
name: PIP2_Abund
type: Parameter

metaid_0000096
constant: true
value: 0.1185
name: koff65
type: Parameter

839199
stoichiometry: 1.0
species: metaid_0000307
type: SpeciesReference

metaid_0000401
kinetic law: 838754
product: 838742
product: 838730
reactant: 838718
reactant: 838706
fast: false
reversible: true
name: Net Grb2/SOS binding
type: Reaction

metaid_0000429
product: 840862
type: Reaction
reactant: 840838
reversible: true
modifier: 840874
name: Net E14/Shc Binding
modifier: 840887
kinetic law: 840899
product: 840850
reactant: 840826
fast: false

metaid_0000034
constant: true
value: 381.2208
name: Kmr49b
type: Parameter

840367
stoichiometry: 1.0
species: metaid_0000325
type: SpeciesReference

836366
stoichiometry: 1.0
species: metaid_0000251
type: SpeciesReference

metaid_0000014
constant: true
value: 444.2921
name: Akt_Abund
type: Parameter

metaid_0000455
fast: false
type: Reaction
reactant: 842315
modifier: 842365
modifier: 842352
modifier: 842377
reversible: true
modifier: 842389
modifier: 842339
name: HRG in EC compartment
product: 842327
modifier: 842401
kinetic law: 842413

metaid_0000342
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: metaid_0000243
name: E44-PTP-1B
type: Species

841780
stoichiometry: 1.0
species: metaid_0000349
type: SpeciesReference

842438
stoichiometry: 1.0
species: metaid_0000315
type: SpeciesReference

metaid_0000095
constant: true
value: 0.4059
name: koff37
type: Parameter

842522
stoichiometry: 1.0
species: metaid_0000356
type: SpeciesReference

838898
stoichiometry: 1.0
species: metaid_0000263
type: SpeciesReference

839211
stoichiometry: 1.0
species: metaid_0000268
type: SpeciesReference

metaid_0000035
constant: true
value: 640.8212
name: kr49b
type: Parameter

836426
stoichiometry: 1.0
species: metaid_0000258
type: SpeciesReference

840439
stoichiometry: 1.0
species: metaid_0000328
type: SpeciesReference

838982
stoichiometry: 1.0
species: metaid_0000297
type: SpeciesReference

metaid_0000004
constant: true
value: 158.0
name: ErbB2_Abund
type: Parameter

metaid_0000341
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: metaid_0000243
name: E24-PTP-1B
type: Species

metaid_0000454
modifier: 842276
kinetic law: 842302
modifier: 842289
type: Reaction
modifier: 842250
reactant: 842224
modifier: 842263
name: EGF in EC compartment
product: 842237
reversible: true
fast: false

metaid_0000015
constant: true
value: 95.7
name: Ras_Abund
type: Parameter

837342
stoichiometry: 1.0
species: metaid_0000259
type: SpeciesReference

839994
stoichiometry: 1.0
species: metaid_0000267
type: SpeciesReference

metaid_0000404
reversible: true
type: Reaction
fast: false
product: 839019
modifier: 839043
reactant: 838994
name: Net Gab1/Shc binding
reactant: 838982
modifier: 839031
product: 839007
kinetic law: 839055

836029
stoichiometry: 1.0
species: metaid_0000247
type: SpeciesReference

metaid_0000094
constant: true
value: 1.2567
name: koff36
type: Parameter

metaid_0000368
kinetic law: 836258
product: 836245
reactant: 836233
reactant: 836221
is version of: GO:0046983
fast: false
reversible: true
name: ErbB3/ErbB4 Heterodimerization
type: Reaction

838115
stoichiometry: 1.0
species: metaid_0000263
type: SpeciesReference

840451
stoichiometry: 1.0
species: metaid_0000291
type: SpeciesReference

metaid_0000036
constant: true
value: 3.6515
name: kf51
type: Parameter

metaid_0000340
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: metaid_0000243
name: E34-PTP-1B
type: Species

metaid_0000453
kinetic law: 842211
product: 842198
reactant: 842185
fast: false
reversible: false
name: 1-1 Dimer Internalization Fraction
type: Reaction

metaid_0000003
constant: true
value: 274.0
name: ErbB1_Abund
type: Parameter

metaid_0000016
constant: true
value: 743.0
name: Raf_Abund
type: Parameter

837609
stoichiometry: 1.0
species: metaid_0000292
type: SpeciesReference

metaid_0000093
constant: true
value: 1.8696
name: koff35
type: Parameter

metaid_0000403
fast: false
kinetic law: 838970
product: 838910
name: Net Shc/Grb2 binding
modifier: 838958
reversible: true
modifier: 838946
type: Reaction
modifier: 838934
reactant: 838886
product: 838922
reactant: 838898

metaid_0000369
kinetic law: 836306
product: 836294
reactant: 836282
reactant: 836270
is version of: GO:0046983
fast: false
reversible: true
name: ErbB2/ErbB4 Heterodimerization
type: Reaction