148269
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148650
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species: metaid_0000099
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147797
stoichiometry: 1.0
species: metaid_0000084
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191600
units: metaid_0000012
value: 5.0
type: LocalParameter

146928
exponent: -1.0
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multipler: 1.0
kind: SECOND
type: SBMLUnit

146592
exponent: 1.0
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multipler: 0.001
kind: DIMENSIONLESS
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metaid_0000102
has part: O95267
initial amount: NaN
has only substance units: false
has part: CHEBI:29108
initial concentration: 0.0
boundary condition: false
constant: false
has part: C00076
substance units: metaid_0000006
type: Species
in compartment: metaid_0000051

147122
stoichiometry: 1.0
species: metaid_0000073
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146676
exponent: -1.0
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multipler: 1.0
kind: SECOND
type: SBMLUnit

191560
units: metaid_0000011
value: 0.0
type: LocalParameter

191570
units: metaid_0000014
value: 600.0
type: LocalParameter

metaid_0000152
kinetic law: 148626
reactant: 148614
is: GO:0046340
fast: false
reversible: true
name: reaction7
type: Reaction

191620
value: 0.27
type: LocalParameter

147435
stoichiometry: 1.0
species: metaid_0000082
type: SpeciesReference

metaid_0000101
is version of: O95267
constant: false
boundary condition: false
has only substance units: false
substance units: metaid_0000006
initial concentration: 30.1
initial amount: NaN
in compartment: metaid_0000051
type: Species

148256
stoichiometry: 1.0
species: metaid_0000067
type: SpeciesReference

191588
units: metaid_0000016
value: 15.0
type: LocalParameter

146616
exponent: 1.0
scale: 0
multipler: 1.0
kind: MOLE
type: SBMLUnit

148204
stoichiometry: 1.0
species: metaid_0000066
type: SpeciesReference

metaid_0000151
kinetic law: 148602
product: 148589
reactant: 148577
reactant: 148565
is version of: GO:0005509
fast: false
reversible: true
name: Ca_binds_IP3R
type: Reaction

191601
units: metaid_0000011
value: 0.0
type: LocalParameter

191598
units: metaid_0000018
value: 10.0
type: LocalParameter

191621
units: metaid_0000011
value: 0.0
type: LocalParameter

146916
exponent: 1.0
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multipler: 1.0
kind: MOLE
type: SBMLUnit

146580
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146904
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multipler: 1.0
kind: METRE
type: SBMLUnit

metaid_0000100
has part: P62070
constant: false
boundary condition: false
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substance units: metaid_0000006
initial concentration: 400.0
initial amount: NaN
in compartment: metaid_0000054
type: Species

147700
stoichiometry: 1.0
species: metaid_0000078
type: SpeciesReference

191572
units: metaid_0000010
value: 1.0
type: LocalParameter

146519
exponent: -2.0
scale: 0
multipler: 1.0
kind: METRE
type: SBMLUnit

191585
units: metaid_0000012
value: 1.0
type: LocalParameter

metaid_0000154
name: flux1
is: GO:0006816
type: Reaction
kinetic law: 148734
fast: false
modifier: 148710
reversible: true
reactant: 148686
modifier: 148722
product: 148698

146664
exponent: -1.0
scale: 0
multipler: 1.0
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148295
stoichiometry: 1.0
species: metaid_0000073
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148614
stoichiometry: 1.0
species: metaid_0000080
type: SpeciesReference

146700
exponent: -3.0
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multipler: 1.0
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147134
stoichiometry: 1.0
species: metaid_0000059
type: SpeciesReference

147447
stoichiometry: 1.0
species: metaid_0000064
type: SpeciesReference

191586
units: metaid_0000011
value: 0.0
type: LocalParameter

W3 CDTF: Tue Jan 29 10:13:13 GMT 2008

metaid_0000153
kinetic law: 148674
modifier: 148662
product: 148650
reactant: 148638
is version of: GO:0003924
fast: false
reversible: true
name: Sos act RasPM
type: Reaction

146604
exponent: -3.0
scale: 0
multipler: 1.0
kind: METRE
type: SBMLUnit

148217
stoichiometry: 1.0
species: metaid_0000063
type: SpeciesReference

metaid_0000060
constant: false
boundary condition: false
has only substance units: false
substance units: metaid_0000006
initial concentration: 45.0
initial amount: NaN
in compartment: metaid_0000055
type: Species

146652
exponent: 3.0
scale: 0
multipler: 1.0
kind: METRE
type: SBMLUnit

metaid_0000142
kinetic law: 148191
product: 148178
reactant: 148166
is version of: GO:0003924
fast: false
reversible: true
name: RasGM basal GAP
type: Reaction

metaid_0000070
constant: false
boundary condition: false
has only substance units: false
substance units: metaid_0000006
initial concentration: 100.0
initial amount: NaN
in compartment: metaid_0000054
type: Species

metaid_0000031
constant: false
units: metaid_0000012
value: NaN
type: Parameter

146892
exponent: -2.0
scale: 0
multipler: 1.0
kind: ITEM
type: SBMLUnit

147001
exponent: -1.0
scale: 0
multipler: 1.0
kind: ITEM
type: SBMLUnit

191610
units: metaid_0000012
value: 0.25
type: LocalParameter

metaid_0000061
boundary condition: false
is: CHEBI:17526
has only substance units: false
in compartment: metaid_0000054
initial concentration: 2857.0
is: C01277
constant: false
initial amount: NaN
substance units: metaid_0000006
type: Species

metaid_0000141
kinetic law: 148153
product: 148140
reactant: 148128
reactant: 148116
fast: false
reversible: true
name: calcium buffer
type: Reaction

191625
units: metaid_0000022
value: 4.69
type: LocalParameter

148308
stoichiometry: 1.0
species: metaid_0000094
type: SpeciesReference

metaid_0000071
initial concentration: 1072.0
is: C04637
is: CHEBI:18348
constant: false
initial amount: NaN
type: Species
substance units: metaid_0000006
in compartment: metaid_0000054
has only substance units: false
boundary condition: false

metaid_0000030
constant: false
units: metaid_0000012
value: NaN
type: Parameter

147411
stoichiometry: 1.0
species: metaid_0000100
type: SpeciesReference

146399
exponent: 2.0
scale: -6
multipler: 1.0
kind: METRE
type: SBMLUnit

147772
stoichiometry: 1.0
species: metaid_0000086
type: SpeciesReference

146712
exponent: 1.0
scale: 0
multipler: 1.0
kind: MOLE
type: SBMLUnit

147859
stoichiometry: 1.0
species: metaid_0000077
type: SpeciesReference

metaid_0000140
kinetic law: 148103
reactant: 148090
is version of: GO:0007176
fast: false
reversible: true
name: EGF_internalization
type: Reaction

191612
units: metaid_0000010
value: 0.0
type: LocalParameter

148698
stoichiometry: 1.0
species: metaid_0000091
type: SpeciesReference

147760
stoichiometry: 1.0
species: metaid_0000069
type: SpeciesReference

metaid_0000072
is version of: P00533
constant: false
boundary condition: false
has only substance units: false
substance units: metaid_0000006
initial concentration: 0.0
initial amount: NaN
in compartment: metaid_0000054
type: Species

148347
stoichiometry: 1.0
species: metaid_0000057
type: SpeciesReference

148140
stoichiometry: 1.0
species: metaid_0000096
type: SpeciesReference

146640
exponent: 1.0
scale: 0
multipler: 1000.0
kind: DIMENSIONLESS
type: SBMLUnit

metaid_0000130
kinetic law: 147676
product: 147664
reactant: 147652
reactant: 147640
is version of: GO:0005515
fast: false
reversible: true
name: sos grb2 binding
type: Reaction

metaid_0000033
constant: false
units: metaid_0000010
value: NaN
type: Parameter

148409
stoichiometry: 1.0
species: metaid_0000085
type: SpeciesReference

metaid_0000150
kinetic law: 148553
modifier: 148541
product: 148529
reactant: 148517
fast: false
reversible: true
name: EGF act PLCgamma
type: Reaction

147195
stoichiometry: 1.0
species: metaid_0000084
type: SpeciesReference

191613
units: metaid_0000011
value: 0.0
type: LocalParameter

metaid_0000073
is: CHEBI:29108
initial concentration: 0.0
has only substance units: false
boundary condition: false
is: C00076
constant: false
substance units: metaid_0000006
type: Species
in compartment: metaid_0000051
initial amount: NaN

146628
exponent: -1.0
scale: 0
multipler: 1.0
kind: SECOND
type: SBMLUnit

191623
units: metaid_0000017
value: 0.8
type: LocalParameter

147847
stoichiometry: 1.0
species: metaid_0000080
type: SpeciesReference

metaid_0000032
constant: false
units: metaid_0000010
value: NaN
type: Parameter

146387
exponent: 1.0
scale: 0
multipler: 1.0E-21
kind: MOLE
type: SBMLUnit

146724
exponent: 1.0
scale: 0
multipler: 1.0E15
kind: DIMENSIONLESS
type: SBMLUnit

148638
stoichiometry: 1.0
species: metaid_0000100
type: SpeciesReference

191578
units: metaid_0000011
value: 0.0
type: LocalParameter

metaid_0000054
is: GO:0005886
constant: true
units: metaid_0000008
size: 0.6
spatial dimensions: 2.0
name: PM
type: Compartment

147835
stoichiometry: 1.0
species: metaid_0000089
type: SpeciesReference

metaid_0000044
constant: true
units: metaid_0000017
value: 0.11
type: Parameter

147074
stoichiometry: 1.0
species: metaid_0000063
type: SpeciesReference

191608
units: metaid_0000011
value: 0.0
type: LocalParameter

148481
stoichiometry: 1.0
species: metaid_0000073
type: SpeciesReference

147170
stoichiometry: 1.0
species: metaid_0000077
type: SpeciesReference

191540
units: metaid_0000012
value: 0.0
type: LocalParameter

191492
units: metaid_0000011
value: 0.0
type: LocalParameter

191568
units: metaid_0000011
value: 0.0
type: LocalParameter

191628
units: metaid_0000023
value: 3.16E-5
type: LocalParameter

metaid_0000064
has only substance units: false
boundary condition: false
substance units: metaid_0000006
constant: false
initial concentration: 0.0
type: Species
initial amount: NaN
has part: C00076
in compartment: metaid_0000054
has part: CHEBI:29108

metaid_0000074
constant: false
boundary condition: false
has only substance units: false
substance units: metaid_0000006
initial concentration: 9.056
initial amount: NaN
in compartment: metaid_0000055
type: Species

146856
exponent: 1.0
scale: 0
multipler: 1.0
kind: MOLE
type: SBMLUnit

146543
exponent: 1.0
scale: 0
multipler: 1.0
kind: SECOND
type: SBMLUnit

191550
units: metaid_0000011
value: 0.0
type: LocalParameter

191590
units: metaid_0000012
value: 1.0
type: LocalParameter

191577
units: metaid_0000012
value: 0.0
type: LocalParameter

147255
stoichiometry: 1.0
species: metaid_0000102
type: SpeciesReference

metaid_0000055
is: GO:0005789
constant: true
units: metaid_0000008
size: 0.0456
spatial dimensions: 2.0
name: erMembrane
type: Compartment

metaid_0000119
kinetic law: 147219
product: 147207
reactant: 147195
is version of: GO:0006886
fast: false
reversible: true
name: RasGTP depal translocate
type: Reaction

metaid_0000045
constant: false
units: metaid_0000012
value: NaN
type: Parameter

147736
stoichiometry: 1.0
species: metaid_0000069
type: SpeciesReference

191567
units: metaid_0000012
value: 10.0
type: LocalParameter

191580
units: metaid_0000016
value: 1.0
type: LocalParameter

metaid_0000065
constant: false
boundary condition: false
has only substance units: false
substance units: metaid_0000006
initial concentration: 2.264
initial amount: NaN
in compartment: metaid_0000055
type: Species

191629
units: metaid_0000011
value: 0.0
type: LocalParameter

metaid_0000075
constant: false
boundary condition: false
has only substance units: false
substance units: metaid_0000006
initial concentration: 7.7825
initial amount: NaN
in compartment: metaid_0000055
type: Species

148686
stoichiometry: 1.0
species: metaid_0000073
type: SpeciesReference

146423
exponent: -1.0
scale: 0
multipler: 1.0
kind: ITEM
type: SBMLUnit

191615
units: metaid_0000014
value: 600.0
type: LocalParameter

metaid_0000056
is: GO:0000139
constant: true
units: metaid_0000008
size: 0.048
spatial dimensions: 2.0
name: GM
type: Compartment

191591
units: metaid_0000011
value: 0.0
type: LocalParameter

147086
stoichiometry: 1.0
species: metaid_0000066
type: SpeciesReference

147279
stoichiometry: 1.0
species: metaid_0000078
type: SpeciesReference

metaid_0000042
constant: false
units: metaid_0000012
value: NaN
type: Parameter

metaid_0000062
initial concentration: 142857.0
has only substance units: false
boundary condition: false
is: C01194
substance units: metaid_0000006
is: CHEBI:16749
constant: false
type: Species
in compartment: metaid_0000054
initial amount: NaN

191626
units: metaid_0000011
value: 0.0
type: LocalParameter

146531
exponent: -1.0
scale: 0
multipler: 1.0
kind: SECOND
type: SBMLUnit

191552
units: metaid_0000019
value: 1.188
type: LocalParameter

191494
units: metaid_0000012
value: 0.2
type: LocalParameter

148589
stoichiometry: 1.0
species: metaid_0000065
type: SpeciesReference

146844
exponent: -2.0
scale: 0
multipler: 1.0
kind: METRE
type: SBMLUnit

191616
units: metaid_0000011
value: 0.0
type: LocalParameter

metaid_0000076
initial concentration: 3.5375
has only substance units: false
boundary condition: false
in compartment: metaid_0000055
substance units: metaid_0000006
constant: false
type: Species
has part: C00076
has part: CHEBI:29108
initial amount: NaN

metaid_0000057
has part: P62070
constant: false
boundary condition: false
has only substance units: false
substance units: metaid_0000006
initial concentration: 0.0
initial amount: NaN
in compartment: metaid_0000056
type: Species

metaid_0000043
constant: true
units: metaid_0000016
value: 2.1
type: Parameter

191565
units: metaid_0000016
value: 50.0
type: LocalParameter

191607
units: metaid_0000016
value: 1000.0
type: LocalParameter

191491
units: metaid_0000012
value: 0.01
type: LocalParameter

metaid_0000063
is version of: P98077
constant: false
boundary condition: false
has only substance units: false
substance units: metaid_0000006
initial concentration: 186.0
initial amount: NaN
in compartment: metaid_0000054
type: Species

146435
exponent: 1.0
scale: 0
multipler: 1.0
kind: MOLE
type: SBMLUnit

metaid_0000077
initial amount: NaN
constant: false
has only substance units: false
type: Species
initial concentration: 0.0
substance units: metaid_0000006
is: CHEBI:16595
in compartment: metaid_0000051
boundary condition: false
is: C01245

191604
units: metaid_0000014
value: 410.0
type: LocalParameter

191631
units: metaid_0000012
value: 1.0E-4
type: LocalParameter

148577
stoichiometry: 1.0
species: metaid_0000073
type: SpeciesReference

metaid_0000116
kinetic law: 147110
modifier: 147098
product: 147086
reactant: 147074
is version of: GO:0006468
fast: false
reversible: true
name: Shc phosphorylation
type: Reaction

metaid_0000040
constant: true
units: metaid_0000013
value: 10.0
type: Parameter

146832
exponent: 1.0
scale: 0
multipler: 1.0E-9
kind: DIMENSIONLESS
type: SBMLUnit

191564
units: metaid_0000010
value: 0.0
type: LocalParameter

191593
units: metaid_0000012
value: 1.0E-4
type: LocalParameter

metaid_0000050
is: GO:0005576
constant: true
size: 1.0
spatial dimensions: 3.0
name: EC
type: Compartment

147231
stoichiometry: 1.0
species: metaid_0000073
type: SpeciesReference

191583
units: metaid_0000016
value: 3.0
type: LocalParameter

191618
units: metaid_0000021
value: 0.0664
type: LocalParameter

metaid_0000078
has part: P62070
constant: false
boundary condition: false
has only substance units: false
substance units: metaid_0000006
initial concentration: 50.0
initial amount: NaN
in compartment: metaid_0000056
type: Species

191496
units: metaid_0000012
value: 0.0
type: LocalParameter

147050
stoichiometry: 1.0
species: metaid_0000071
type: SpeciesReference

191532
units: metaid_0000012
value: 0.01
type: LocalParameter

metaid_0000068
constant: false
boundary condition: false
has only substance units: false
substance units: metaid_0000006
initial concentration: 0.0
initial amount: NaN
in compartment: metaid_0000054
type: Species

191544
units: metaid_0000011
value: 0.0
type: LocalParameter

BIOMD0000000161
reaction: metaid_0000146
is part of: GO:0007173
compartment: metaid_0000056
units def: metaid_0000021
units def: metaid_0000018
parameter: metaid_0000040
parameter: metaid_0000030
species: metaid_0000095
rule: metaid_0000104
rule: metaid_0000114
parameter: metaid_0000034
curated: true
reaction: metaid_0000153
units def: metaid_0000006
reaction: metaid_0000116
parameter: metaid_0000033
reaction: metaid_0000131
rule: metaid_0000109
species: metaid_0000096
reaction: metaid_0000126
length unit: length
reaction: metaid_0000115
species: metaid_0000061
rule: metaid_0000105
parameter: metaid_0000039
reaction: metaid_0000134
reaction: metaid_0000124
reaction: metaid_0000152
occurs in: http://identifiers.org/taxonomy/131567
units def: metaid_0000009
parameter: metaid_0000028
reaction: metaid_0000118
reaction: metaid_0000144
species: metaid_0000083
reaction: metaid_0000141
parameter: metaid_0000048
parameter: metaid_0000038
rule: metaid_0000111
reaction: metaid_0000133
time units: metaid_0000120
name: Eungdamrong2007_Ras_Activation
species: metaid_0000069
reaction: metaid_0000151
units def: metaid_0000016
parameter: metaid_0000042
parameter: metaid_0000046
species: metaid_0000065
units def: metaid_0000004
species: metaid_0000057
reaction: metaid_0000154
reaction: metaid_0000157
units def: metaid_0000007
has part: GO:0007265
units def: metaid_0000015
reaction: metaid_0000138
reaction: metaid_0000128
reaction: metaid_0000132
species: metaid_0000087
is described by: http://identifiers.org/pubmed/17098795
parameter: metaid_0000026
reaction: metaid_0000121
reaction: metaid_0000148
species: metaid_0000081
units def: metaid_0000014
species: metaid_0000060
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units def: metaid_0000022
reaction: metaid_0000137
compartment: metaid_0000051
species: metaid_0000067
reaction: metaid_0000156
species: metaid_0000082
volume units: metaid_0000004
compartment: metaid_0000055
reaction: metaid_0000145
reaction: metaid_0000135
species: metaid_0000071
species: metaid_0000063
species: metaid_0000102
compartment: metaid_0000050

metaid_0000115
kinetic law: 147062
product: 147050
reactant: 147038
is: GO:0016308
fast: false
reversible: true
name: PIP2 synthesis
type: Reaction

191605
units: metaid_0000011
value: 0.0
type: LocalParameter

metaid_0000041
constant: false
units: metaid_0000012
value: NaN
type: Parameter

metaid_0000051
is: GO:0005829
constant: true
size: 0.976
spatial dimensions: 3.0
name: cyt
type: Compartment

191573
units: metaid_0000011
value: 0.0
type: LocalParameter

146507
exponent: 1.0
scale: 0
multipler: 1.0
kind: AMPERE
type: SBMLUnit

146447
exponent: 1.0
scale: 0
multipler: 1.0E12
kind: DIMENSIONLESS
type: SBMLUnit

147895
stoichiometry: 1.0
species: metaid_0000078
type: SpeciesReference

191553
units: metaid_0000011
value: 0.0
type: LocalParameter

metaid_0000079
boundary condition: false
has only substance units: false
in compartment: metaid_0000056
has part: O95267
has part: C00076
has part: CHEBI:29108
initial concentration: 0.0
substance units: metaid_0000006
initial amount: NaN
type: Species
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191497
units: metaid_0000011
value: 0.0
type: LocalParameter

metaid_0000069
has part: P62070
constant: false
boundary condition: false
has only substance units: false
substance units: metaid_0000006
initial concentration: 0.0
initial amount: NaN
in compartment: metaid_0000051
type: Species

191543
units: metaid_0000012
value: 0.0
type: LocalParameter

191595
units: metaid_0000018
value: 0.0
type: LocalParameter

147243
stoichiometry: 1.0
species: metaid_0000101
type: SpeciesReference

191562
units: metaid_0000012
value: 0.002
type: LocalParameter

191633
units: metaid_0000018
value: 0.0
type: LocalParameter

191602
units: metaid_0000011
value: 0.0
type: LocalParameter

metaid_0000118
kinetic law: 147183
reactant: 147170
fast: false
reversible: true
name: IP3 degradation
type: Reaction

148243
stoichiometry: 1.0
species: metaid_0000058
type: SpeciesReference

148565
stoichiometry: 1.0
species: metaid_0000074
type: SpeciesReference

metaid_0000052
is: GO:0005783
constant: true
size: 0.012
spatial dimensions: 3.0
name: er
type: Compartment

146820
exponent: -1.0
scale: 0
multipler: 1.0
kind: SECOND
type: SBMLUnit

191520
units: metaid_0000011
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type: LocalParameter

148493
stoichiometry: 1.0
species: metaid_0000076
type: SpeciesReference

191530
units: metaid_0000018
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type: LocalParameter

metaid_0000066
is version of: P98077
constant: false
boundary condition: false
has only substance units: false
substance units: metaid_0000006
initial concentration: 0.0
initial amount: NaN
in compartment: metaid_0000054
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148090
stoichiometry: 1.0
species: metaid_0000072
type: SpeciesReference

metaid_0000117
kinetic law: 147158
product: 147146
reactant: 147134
reactant: 147122
is version of: GO:0005509
fast: false
reversible: true
name: Ca bind CAPRI
type: Reaction

191596
units: metaid_0000011
value: 0.0
type: LocalParameter

146459
exponent: 1.0
scale: 0
multipler: 1.0
kind: ITEM
type: SBMLUnit

191582
units: metaid_0000012
value: 0.01
type: LocalParameter

191575
units: metaid_0000012
value: 0.5
type: LocalParameter

metaid_0000053
is: GO:0005794
constant: true
size: 0.012
spatial dimensions: 3.0
name: Golgi
type: Compartment

191499
units: metaid_0000012
value: 1.0E-4
type: LocalParameter

191555
units: metaid_0000016
value: 90.0
type: LocalParameter

147724
stoichiometry: 1.0
species: metaid_0000057
type: SpeciesReference

191541
units: metaid_0000012
value: 1.0E-4
type: LocalParameter

metaid_0000067
is version of: P00533
constant: false
boundary condition: false
has only substance units: false
substance units: metaid_0000006
initial concentration: 21.0
initial amount: NaN
in compartment: metaid_0000054
type: Species

191475
units: metaid_0000017
value: 0.0
type: LocalParameter

146988
exponent: 1.0
scale: 0
multipler: 1.0E-18
kind: DIMENSIONLESS
type: SBMLUnit

148529
stoichiometry: 1.0
species: metaid_0000068
type: SpeciesReference

146411
exponent: 1.0
scale: 0
multipler: 1.0E-21
kind: DIMENSIONLESS
type: SBMLUnit

metaid_0000087
in compartment: metaid_0000051
constant: false
substance units: metaid_0000006
type: Species
has part: C00076
initial concentration: 0.0
initial amount: NaN
has only substance units: false
boundary condition: false
has part: CHEBI:29108

146568
exponent: 1.0
scale: 0
multipler: 1.0
kind: ITEM
type: SBMLUnit

148469
stoichiometry: 1.0
species: metaid_0000075
type: SpeciesReference

146760
exponent: -1.0
scale: 0
multipler: 1.0
kind: MOLE
type: SBMLUnit

191501
units: metaid_0000012
value: 0.0
type: LocalParameter

147967
stoichiometry: 1.0
species: metaid_0000077
type: SpeciesReference

148003
stoichiometry: 1.0
species: metaid_0000097
type: SpeciesReference

191557
units: metaid_0000012
value: 0.1
type: LocalParameter

147604
stoichiometry: 1.0
species: metaid_0000086
type: SpeciesReference

146495
exponent: 1.0
scale: 0
multipler: 1.0
kind: DIMENSIONLESS
type: SBMLUnit

191535
units: metaid_0000012
value: 1.58489319246111E-4
type: LocalParameter

metaid_0000127
kinetic law: 147544
product: 147532
reactant: 147520
is version of: GO:0006886
fast: false
reversible: true
name: RasGDP pal
type: Reaction

191547
units: metaid_0000011
value: 0.0
type: LocalParameter

148116
stoichiometry: 1.0
species: metaid_0000095
type: SpeciesReference

191516
units: metaid_0000018
value: 1.0E-5
type: LocalParameter

146555
exponent: 1.0
scale: 0
multipler: 1.0E12
kind: DIMENSIONLESS
type: SBMLUnit

metaid_0000086
has part: P62070
constant: false
boundary condition: false
has only substance units: false
substance units: metaid_0000006
initial concentration: 0.0
initial amount: NaN
in compartment: metaid_0000051
type: Species

191522
units: metaid_0000018
value: 120.0
type: LocalParameter

191502
units: metaid_0000011
value: 0.0
type: LocalParameter

191484
units: metaid_0000011
value: 0.0
type: LocalParameter

147809
stoichiometry: 1.0
species: metaid_0000085
type: SpeciesReference

191558
units: metaid_0000011
value: 0.0
type: LocalParameter

148914
stoichiometry: 1.0
species: metaid_0000084
type: SpeciesReference

147520
stoichiometry: 1.0
species: metaid_0000078
type: SpeciesReference

metaid_0000128
kinetic law: 147592
modifier: 147580
product: 147568
reactant: 147556
is version of: GO:0003924
fast: false
reversible: true
name: CAPRI GAP
type: Reaction

191533
units: metaid_0000011
value: 0.0
type: LocalParameter

147484
stoichiometry: 1.0
species: metaid_0000101
type: SpeciesReference

metaid_0000089
is: CHEBI:18348
has only substance units: false
substance units: metaid_0000006
in compartment: metaid_0000056
initial amount: NaN
constant: false
initial concentration: 250.0
is: C04637
type: Species
boundary condition: true

146976
exponent: -1.0
scale: 0
multipler: 1.0
kind: SECOND
type: SBMLUnit

metaid_0000039
constant: true
units: metaid_0000013
value: 0.05
type: Parameter

191473
units: metaid_0000012
value: 0.5
type: LocalParameter

metaid_0000099
has part: P62070
constant: false
boundary condition: false
has only substance units: false
substance units: metaid_0000006
initial concentration: 0.0
initial amount: NaN
in compartment: metaid_0000054
type: Species

148517
stoichiometry: 1.0
species: metaid_0000070
type: SpeciesReference

191487
units: metaid_0000011
value: 0.0
type: LocalParameter

147146
stoichiometry: 1.0
species: metaid_0000082
type: SpeciesReference

metaid_0000139
kinetic law: 148078
product: 148065
reactant: 148052
is: GO:0004430
fast: false
reversible: true
name: PIP synthesis
type: Reaction

147955
stoichiometry: 1.0
species: metaid_0000083
type: SpeciesReference

147907
stoichiometry: 1.0
species: metaid_0000057
type: SpeciesReference

metaid_0000059
constant: false
boundary condition: false
has only substance units: false
substance units: metaid_0000006
initial concentration: 30.1
initial amount: NaN
in compartment: metaid_0000051
type: Species

metaid_0000129
kinetic law: 147628
product: 147616
reactant: 147604
is version of: GO:0006886
fast: false
reversible: true
name: RasGDPpal translocation
type: Reaction

147616
stoichiometry: 1.0
species: metaid_0000100
type: SpeciesReference

147291
stoichiometry: 1.0
species: metaid_0000057
type: SpeciesReference

metaid_0000058
constant: false
boundary condition: true
has only substance units: false
substance units: metaid_0000006
initial concentration: 4.02136
initial amount: NaN
in compartment: metaid_0000050
type: Species

191514
units: metaid_0000012
value: 0.015
type: LocalParameter

191472
units: metaid_0000012
value: 0.5
type: LocalParameter

metaid_0000038
constant: true
units: metaid_0000012
value: 0.01
type: Parameter

metaid_0000088
type: Species
boundary condition: false
substance units: metaid_0000006
in compartment: metaid_0000056
has part: C00076
initial concentration: 0.0
has part: P62070
has only substance units: false
initial amount: NaN
constant: false
has part: CHEBI:29108

191486
units: metaid_0000014
value: 600.0
type: LocalParameter

191504
units: metaid_0000018
value: 120.0
type: LocalParameter

metaid_0000098
constant: false
boundary condition: false
has only substance units: false
substance units: metaid_0000006
initial concentration: 0.0
initial amount: NaN
in compartment: metaid_0000054
type: Species

147532
stoichiometry: 1.0
species: metaid_0000086
type: SpeciesReference

191524
units: metaid_0000012
value: 0.01
type: LocalParameter

191546
units: metaid_0000019
value: 1.18
type: LocalParameter

148866
stoichiometry: 1.0
species: metaid_0000091
type: SpeciesReference

148027
stoichiometry: 1.0
species: metaid_0000098
type: SpeciesReference

191481
units: metaid_0000016
value: 0.1
type: LocalParameter

148321
stoichiometry: 1.0
species: metaid_0000087
type: SpeciesReference

metaid_0000037
constant: true
units: metaid_0000012
value: 0.0015
type: Parameter

146471
exponent: -2.0
scale: 0
multipler: 1.0
kind: METRE
type: SBMLUnit

147943
stoichiometry: 1.0
species: metaid_0000071
type: SpeciesReference

191511
units: metaid_0000012
value: 0.1
type: LocalParameter

148445
stoichiometry: 1.0
species: metaid_0000079
type: SpeciesReference

147399
stoichiometry: 1.0
species: metaid_0000099
type: SpeciesReference

metaid_0000047
constant: true
units: metaid_0000012
value: 0.2
type: Parameter

146964
exponent: 5.0
scale: 0
multipler: 1.0
kind: METRE
type: SBMLUnit

191525
units: metaid_0000016
value: 0.025
type: LocalParameter

146868
exponent: -1.0
scale: 0
multipler: 1.0
kind: SECOND
type: SBMLUnit

191470
units: metaid_0000016
value: 0.1
type: LocalParameter

148397
stoichiometry: 1.0
species: metaid_0000100
type: SpeciesReference

191480
units: metaid_0000012
value: 0.01
type: LocalParameter

147688
stoichiometry: 1.0
species: metaid_0000085
type: SpeciesReference

146346
exponent: 3.0
scale: -6
multipler: 1.0
kind: METRE
type: SBMLUnit

147207
stoichiometry: 1.0
species: metaid_0000057
type: SpeciesReference

148065
stoichiometry: 1.0
species: metaid_0000061
type: SpeciesReference

147363
stoichiometry: 1.0
species: metaid_0000068
type: SpeciesReference

metaid_0000036
constant: true
units: metaid_0000014
value: 2857.0
type: Parameter

147339
stoichiometry: 1.0
species: metaid_0000099
type: SpeciesReference

191512
units: metaid_0000011
value: 0.0
type: LocalParameter

metaid_0000046
constant: false
units: metaid_0000010
value: NaN
type: Parameter

metaid_0000049
constant: false
units: metaid_0000010
value: NaN
type: Parameter

146483
exponent: -1.0
scale: 0
multipler: 1.0
kind: SECOND
type: SBMLUnit

191483
units: metaid_0000012
value: 0.5
type: LocalParameter

148052
stoichiometry: 1.0
species: metaid_0000062
type: SpeciesReference

148015
stoichiometry: 1.0
species: metaid_0000066
type: SpeciesReference

191549
units: metaid_0000014
value: 1200.0
type: LocalParameter

148433
stoichiometry: 1.0
species: metaid_0000102
type: SpeciesReference

metaid_0000035
constant: false
units: metaid_0000010
value: NaN
type: Parameter

191537
units: metaid_0000018
value: 1.0E-5
type: LocalParameter

146952
exponent: -2.0
scale: 0
multipler: 1.0
kind: ITEM
type: SBMLUnit

191527
units: metaid_0000012
value: 0.0168
type: LocalParameter

146358
exponent: 2.0
scale: -6
multipler: 1.0
kind: METRE
type: SBMLUnit

metaid_0000048
constant: false
units: metaid_0000012
value: NaN
type: Parameter

147471
stoichiometry: 1.0
species: metaid_0000080
type: SpeciesReference

metaid_0000034
constant: false
units: metaid_0000010
value: NaN
type: Parameter

191538
units: metaid_0000012
value: 1.0E-4
type: LocalParameter

147375
stoichiometry: 1.0
species: metaid_0000070
type: SpeciesReference

191528
units: metaid_0000011
value: 0.0
type: LocalParameter

147327
stoichiometry: 1.0
species: metaid_0000069
type: SpeciesReference

146748
exponent: 1.0
scale: 0
multipler: 1.0
kind: METRE
type: SBMLUnit

147025
exponent: -1.0
scale: 0
multipler: 1.0
kind: SECOND
type: SBMLUnit

metaid_0000147
kinetic law: 148421
product: 148409
reactant: 148397
is version of: GO:0006886
fast: false
reversible: true
name: RasGDP depal2
type: Reaction

metaid_0000093
is version of: P62993
constant: false
boundary condition: false
has only substance units: false
substance units: metaid_0000006
initial concentration: 502.67
initial amount: NaN
in compartment: metaid_0000051
type: Species

148373
stoichiometry: 1.0
species: metaid_0000088
type: SpeciesReference

191509
units: metaid_0000016
value: 0.5
type: LocalParameter

metaid_0000133
kinetic law: 147784
product: 147772
reactant: 147760
is version of: GO:0003924
fast: false
reversible: true
name: RasPal basal GAP
type: Reaction

147664
stoichiometry: 1.0
species: metaid_0000097
type: SpeciesReference

147568
stoichiometry: 1.0
species: metaid_0000100
type: SpeciesReference

146688
exponent: 1.0
scale: 0
multipler: 0.001
kind: DIMENSIONLESS
type: SBMLUnit

146940
exponent: 1.0
scale: 0
multipler: 1.0E-30
kind: DIMENSIONLESS
type: SBMLUnit

146333
exponent: 1.0
scale: 0
multipler: 1.0
kind: ITEM
type: SBMLUnit

148360
stoichiometry: 1.0
species: metaid_0000087
type: SpeciesReference

metaid_0000092
is version of: Q07889
constant: false
boundary condition: false
has only substance units: false
substance units: metaid_0000006
initial concentration: 81.27
initial amount: NaN
in compartment: metaid_0000051
type: Species

metaid_0000120
kinetic law: 147267
product: 147255
reactant: 147243
reactant: 147231
is version of: GO:0005509
fast: false
reversible: true
name: ca bind rasGRP
type: Reaction

metaid_0000148
kinetic law: 148457
product: 148445
reactant: 148433
is version of: GO:0006886
fast: false
reversible: true
name: CaRasGRP translocation
type: Reaction

metaid_0000134
kinetic law: 147822
product: 147809
reactant: 147797
is version of: GO:0003924
fast: false
reversible: true
name: basal cyt depal GEF
type: Reaction

191467
units: metaid_0000011
value: 0.0
type: LocalParameter

146736
exponent: 1.0
scale: 0
multipler: 1.0
kind: ITEM
type: SBMLUnit

metaid_0000024
constant: true
units: metaid_0000009
value: 0.00166112956810631
type: Parameter

metaid_0000149
kinetic law: 148505
product: 148493
reactant: 148481
reactant: 148469
is version of: GO:0005509
fast: false
reversible: true
name: reaction2
type: Reaction

146880
exponent: 1.0
scale: 0
multipler: 1.0E-33
kind: DIMENSIONLESS
type: SBMLUnit

metaid_0000091
has only substance units: false
initial concentration: 120400.0
constant: false
is: C00076
type: Species
initial amount: NaN
boundary condition: false
substance units: metaid_0000006
is: CHEBI:29108
in compartment: metaid_0000052

metaid_0000121
kinetic law: 147315
modifier: 147303
product: 147291
reactant: 147279
is version of: GO:0005085
fast: false
reversible: true
name: RasGRP_DAG GEF
type: Reaction

147652
stoichiometry: 1.0
species: metaid_0000093
type: SpeciesReference

148746
stoichiometry: 1.0
species: metaid_0000073
type: SpeciesReference

147013
exponent: 3.0
scale: 0
multipler: 1.0
kind: METRE
type: SBMLUnit

metaid_0000081
has part: O95267
constant: false
boundary condition: false
has only substance units: false
substance units: metaid_0000006
initial concentration: 0.0
initial amount: NaN
in compartment: metaid_0000056
type: Species

metaid_0000131
kinetic law: 147712
product: 147700
reactant: 147688
is version of: GO:0006886
fast: false
reversible: true
name: RasGDP depal translocate
type: Reaction

191466
units: metaid_0000011
value: 0.0
type: LocalParameter

146796
exponent: -1.0
scale: 0
multipler: 1.0
kind: ITEM
type: SBMLUnit

metaid_0000025
constant: true
units: metaid_0000012
value: 0.01
type: Parameter

metaid_0000090
constant: false
boundary condition: true
has only substance units: false
substance units: metaid_0000006
initial concentration: 2.0
initial amount: NaN
in compartment: metaid_0000055
type: Species

metaid_0000122
kinetic law: 147351
product: 147339
reactant: 147327
is version of: GO:0006886
fast: false
reversible: true
name: rasGTP pal translocation
type: Reaction

metaid_0000132
kinetic law: 147748
product: 147736
reactant: 147724
is version of: GO:0006886
fast: false
reversible: true
name: Ras GTP palm1
type: Reaction

metaid_0000080
has only substance units: false
constant: false
initial amount: NaN
is: CHEBI:18035
type: Species
in compartment: metaid_0000056
is: C00165
initial concentration: 0.0
boundary condition: false
substance units: metaid_0000006

metaid_0000143
kinetic law: 148230
product: 148217
reactant: 148204
fast: false
reversible: true
name: reaction0
type: Reaction

148758
stoichiometry: 1.0
species: metaid_0000091
type: SpeciesReference

148854
stoichiometry: 1.0
species: metaid_0000073
type: SpeciesReference

metaid_0000137
is: GO:0004435
type: Reaction
modifier: 147979
fast: false
product: 147955
reactant: 147943
name: PIP2 hydrolysis
reversible: true
kinetic law: 147991
product: 147967

147640
stoichiometry: 1.0
species: metaid_0000092
type: SpeciesReference

metaid_0000157
kinetic law: 148926
product: 148914
reactant: 148902
is: GO:0006886
fast: false
reversible: true
name: Ras PM depal1
type: Reaction

metaid_0000097
has only substance units: false
substance units: metaid_0000006
has part: P62993
constant: false
type: Species
initial concentration: 99.33
in compartment: metaid_0000051
boundary condition: false
has part: Q07889
initial amount: NaN

metaid_0000083
is: C00165
boundary condition: false
substance units: metaid_0000006
is: CHEBI:18035
constant: false
initial amount: NaN
initial concentration: 2000.0
type: Species
in compartment: metaid_0000054
has only substance units: false

191489
units: metaid_0000018
value: 120.0
type: LocalParameter

metaid_0000123
kinetic law: 147387
product: 147375
reactant: 147363
is version of: GO:0010519
fast: false
reversible: true
name: PLCg dephos
type: Reaction

191519
units: metaid_0000014
value: 1200.0
type: LocalParameter

metaid_0000026
constant: true
units: metaid_0000013
value: 0.05
type: Parameter

W3 CDTF: Thu Jul 05 17:46:42 BST 2012

metaid_0000144
kinetic law: 148282
product: 148269
reactant: 148256
reactant: 148243
is: GO:0045741
fast: false
reversible: true
name: EGFR_binding
type: Reaction

metaid_0000138
kinetic law: 148039
product: 148027
reactant: 148015
reactant: 148003
is version of: GO:0005515
fast: false
reversible: true
name: Sos activation
type: Reaction

191468
units: metaid_0000014
value: 1032.0
type: LocalParameter

metaid_0000096
constant: false
boundary condition: false
has only substance units: false
substance units: metaid_0000006
initial concentration: 0.0
initial amount: NaN
in compartment: metaid_0000051
type: Species

metaid_0000082
initial concentration: 0.0
boundary condition: false
substance units: metaid_0000006
type: Species
has part: CHEBI:29108
has only substance units: false
in compartment: metaid_0000051
has part: C00076
constant: false
initial amount: NaN

191506
units: metaid_0000012
value: 0.1
type: LocalParameter

metaid_0000124
kinetic law: 147423
product: 147411
reactant: 147399
is version of: GO:0005099
fast: false
reversible: true
name: basal GAP
type: Reaction

147496
stoichiometry: 1.0
species: metaid_0000081
type: SpeciesReference

metaid_0000027
constant: true
units: metaid_0000013
value: 10.0
type: Parameter

191478
units: metaid_0000018
value: 120.0
type: LocalParameter

148178
stoichiometry: 1.0
species: metaid_0000078
type: SpeciesReference

146784
exponent: 1.0
scale: 0
multipler: 1.0E-12
kind: DIMENSIONLESS
type: SBMLUnit

metaid_0000125
kinetic law: 147459
product: 147447
reactant: 147435
is version of: GO:0006886
fast: false
reversible: true
name: CAPRI translocation
type: Reaction

metaid_0000145
kinetic law: 148334
product: 148321
reactant: 148308
reactant: 148295
is version of: GO:0005509
fast: false
reversible: true
name: ca act PLCe
type: Reaction

147556
stoichiometry: 1.0
species: metaid_0000099
type: SpeciesReference

metaid_0000155
is: GO:0006816
type: Reaction
kinetic law: 148842
modifier: 148830
fast: false
reactant: 148746
modifier: 148806
modifier: 148818
modifier: 148782
modifier: 148770
modifier: 148794
reversible: true
product: 148758
name: flux0

146808
exponent: 2.0
scale: 0
multipler: 1.0
kind: METRE
type: SBMLUnit

148902
stoichiometry: 1.0
species: metaid_0000099
type: SpeciesReference

metaid_0000135
kinetic law: 147883
reactant: 147835
is: GO:0006651
product: 147859
name: caPLCe gen DAG
is: GO:0004435
type: Reaction
reversible: true
fast: false
product: 147847
modifier: 147871

146370
exponent: 1.0
scale: 0
multipler: 1.0
kind: ITEM
type: SBMLUnit

191507
units: metaid_0000011
value: 0.0
type: LocalParameter

metaid_0000095
constant: false
boundary condition: false
has only substance units: false
substance units: metaid_0000006
initial concentration: 120.4
initial amount: NaN
in compartment: metaid_0000051
type: Species

191517
units: metaid_0000011
value: 0.0
type: LocalParameter

metaid_0000028
constant: true
units: metaid_0000014
value: 1072.0
type: Parameter

metaid_0000085
has part: P62070
constant: false
boundary condition: false
has only substance units: false
substance units: metaid_0000006
initial concentration: 0.0
initial amount: NaN
in compartment: metaid_0000051
type: Species

148128
stoichiometry: 1.0
species: metaid_0000073
type: SpeciesReference

metaid_0000126
kinetic law: 147508
product: 147496
reactant: 147484
reactant: 147471
is version of: GO:0019992
fast: false
reversible: true
name: reaction5
type: Reaction

metaid_0000146
kinetic law: 148385
product: 148373
reactant: 148360
reactant: 148347
fast: false
reversible: true
name: ras_act_PLCe
type: Reaction

metaid_0000156
kinetic law: 148890
modifier: 148878
product: 148866
reactant: 148854
is: GO:0006816
fast: false
reversible: true
name: flux2
type: Reaction

147038
stoichiometry: 1.0
species: metaid_0000061
type: SpeciesReference

metaid_0000136
kinetic law: 147931
modifier: 147919
product: 147907
reactant: 147895
is version of: GO:0005085
fast: false
reversible: true
name: CaRasGRP act RasGM
type: Reaction

148166
stoichiometry: 1.0
species: metaid_0000057
type: SpeciesReference

146772
exponent: -1.0
scale: 0
multipler: 1.0
kind: SECOND
type: SBMLUnit

metaid_0000084
has part: P62070
constant: false
boundary condition: false
has only substance units: false
substance units: metaid_0000006
initial concentration: 0.0
initial amount: NaN
in compartment: metaid_0000051
type: Species

metaid_0000029
constant: true
units: metaid_0000012
value: 0.045
type: Parameter

191476
units: metaid_0000011
value: 0.0
type: LocalParameter

metaid_0000094
constant: false
boundary condition: false
has only substance units: false
substance units: metaid_0000006
initial concentration: 12.04
initial amount: NaN
in compartment: metaid_0000051
type: Species

given: Harish
family: Dharuri

orgname: California Institute of Technology