metaid_0000012
is: Q00987
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.2
initial amount: NaN
in compartment: metaid_0000009
name: Mdm2
type: Species

metaid_0000018
kinetic law: 842659
product: 842646
reactant: 842633
is version of: GO:0006412
fast: false
reversible: false
name: Mdm2 synthesis from precursor
type: Reaction

metaid_0000016
kinetic law: 842620
modifier: 842607
product: 842595
is version of: GO:0006351
fast: false
reversible: false
name: p53 dependent Mdm2 precursor production
type: Reaction

metaid_0000006
constant: true
value: 3.7
type: Parameter

metaid_0000004
constant: true
value: 1.0
type: Parameter

metaid_0000008
constant: true
value: 0.9
type: Parameter

842672
stoichiometry: 1.0
species: metaid_0000012
type: SpeciesReference

metaid_0000025
constant: true
value: 2.0
type: Parameter

842595
stoichiometry: 1.0
species: metaid_0000022
type: SpeciesReference

842633
stoichiometry: 1.0
species: metaid_0000022
type: SpeciesReference

842520
exponent: 1.0
scale: 0
multipler: 3600.0
kind: SECOND
type: SBMLUnit

842507
exponent: 1.0
scale: 0
multipler: 1.0
kind: ITEM
type: SBMLUnit

metaid_0000023
constant: true
value: 1.1
type: Parameter

842533
stoichiometry: 1.0
species: metaid_0000011
type: SpeciesReference

842557
stoichiometry: 1.0
species: metaid_0000011
type: SpeciesReference

metaid_0000011
is version of: P04637
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.02
initial amount: NaN
in compartment: metaid_0000009
name: p53
type: Species

metaid_0000015
kinetic law: 842582
modifier: 842570
reactant: 842557
is version of: GO:0042176
fast: false
reversible: false
name: Mdm2 dependent p53 degradation
type: Reaction

metaid_0000005
constant: true
value: 0.0
type: Parameter

metaid_0000013
kinetic law: 842545
product: 842533
is version of: GO:0006412
fast: false
reversible: false
name: p53 production
type: Reaction

metaid_0000007
constant: true
value: 1.5
type: Parameter

842646
stoichiometry: 1.0
species: metaid_0000012
type: SpeciesReference

metaid_0000024
kinetic law: 842685
reactant: 842672
is version of: GO:0044257
fast: false
reversible: true
name: Mdm2 degradation
type: Reaction

metaid_0000009
is: GO:0005623
constant: true
size: 1.0
spatial dimensions: 3.0
name: cell
type: Compartment

metaid_0000022
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.5
initial amount: NaN
in compartment: metaid_0000009
name: precursor Mdm2
type: Species

metaid_0000019
unit: 842507
name: dimensionless
type: SBMLUnitsDef

BIOMD0000000156
parameter: metaid_0000005
curated: true
units def: metaid_0000020
parameter: metaid_0000006
parameter: metaid_0000007
species: metaid_0000011
substance units: metaid_0000019
volume units: metaid_0000084
parameter: metaid_0000008
creator:
  ORG:
    orgname: California Institute of Technology
  n:
    given: Harish
    family: Dharuri
reaction: metaid_0000013
is: MODEL0076384106
is part of: hsa04115
parameter: metaid_0000025
reaction: metaid_0000015
type: SBMLModel
occurs in: http://identifiers.org/taxonomy/9606
reaction: metaid_0000016
notes: The model reproduces time profile of p53 and Mdm2 as depicted in Fig 6B of the paper for Model 5. Results obtained using MathSBML. To the extent possible under law, all copyright and related or neighbouring rights to this encoded model have been dedicated to the public domain worldwide. Please refer to CC0 Public Domain Dedication for more information. In summary, you are entitled to use this encoded model in absolutely any manner you deem suitable, verbatim, or with modification, alone or embedded it in a larger context, redistribute it, commercially or not, in a restricted way or not. To cite BioModels Database, please use: Li C, Donizelli M, Rodriguez N, Dharuri H, Endler L, Chelliah V, Li L, He E, Henry A, Stefan MI, Snoep JL, Hucka M, Le Novère N, Laibe C (2010) BioModels Database: An enhanced, curated and annotated resource for published quantitative kinetic models. BMC Syst Biol., 4:92.
species: metaid_0000022
time units: metaid_0000020
name: Zatorsky2006_p53_Model5
is part of: GO:0042771
area units: metaid_0000005
parameter: metaid_0000023
is described by: http://identifiers.org/pubmed/16773083
reaction: metaid_0000018
species: metaid_0000012
compartment: metaid_0000009
modified:
  W3 CDTF: Thu Jul 05 15:44:40 BST 2012
reaction: metaid_0000024
parameter: metaid_0000004
units def: metaid_0000019
created:
  W3 CDTF: Thu Jan 10 17:38:04 GMT 2008
length unit: length

metaid_0000020
unit: 842520
name: hours
type: SBMLUnitsDef