metaid_0000027
kinetic law: 422360
product: 422348
reactant: 422336
reactant: 422324
is version of: GO:0019901
fast: false
reversible: false
name: D34_CK1_binding
type: Reaction

426211
stoichiometry: 1.0
species: metaid_0000049
type: SpeciesReference

427906
stoichiometry: 1.0
species: metaid_0000161
type: SpeciesReference

424367
stoichiometry: 1.0
species: metaid_0000076
type: SpeciesReference

422348
stoichiometry: 1.0
species: metaid_0000028
type: SpeciesReference

428511
stoichiometry: 1.0
species: metaid_0000161
type: SpeciesReference

metaid_0000172
kinetic law: 428171
product: 428159
product: 428147
reactant: 428135
fast: false
reversible: false
name: cAMP4_R2C2_unbinding
type: Reaction

metaid_0000102
kinetic law: 425365
product: 425353
reactant: 425341
reactant: 425328
is version of: GO:0051721
fast: false
reversible: false
name: D75:137_PP2A_binding
type: Reaction

metaid_0000122
kinetic law: 426283
product: 426271
reactant: 426259
reactant: 426247
is version of: GO:0019903
fast: false
reversible: false
name: D34:137_PP2C_binding
type: Reaction

423911
stoichiometry: 1.0
species: metaid_0000019
type: SpeciesReference

425624
value: 10.0
name: kcat25
type: LocalParameter

421964
stoichiometry: 1.0
species: metaid_0000015
type: SpeciesReference

426908
stoichiometry: 1.0
species: metaid_0000138
type: SpeciesReference

427137
stoichiometry: 1.0
species: metaid_0000143
type: SpeciesReference

metaid_0000152
kinetic law: 427449
product: 427437
reactant: 427425
is version of: http://identifiers.org/ec-code/3.1.3.16
fast: false
reversible: false
name: PP2AP_dephospho
type: Reaction

422997
stoichiometry: 1.0
species: metaid_0000049
type: SpeciesReference

429173
persistant: true
initial value: true
type: Trigger

424500
stoichiometry: 1.0
species: metaid_0000080
type: SpeciesReference

426511
stoichiometry: 1.0
species: metaid_0000066
type: SpeciesReference

428014
stoichiometry: 1.0
species: metaid_0000164
type: SpeciesReference

426427
stoichiometry: 1.0
species: metaid_0000053
type: SpeciesReference

422684
stoichiometry: 1.0
species: metaid_0000030
type: SpeciesReference

metaid_0000103
type: Species
initial concentration: 0.0
has part: IPR006186
in compartment: metaid_0000003
constant: false
has part: Q9UD71
boundary condition: false
has only substance units: false
initial amount: NaN
name: D75:137_PP2A

metaid_0000173
fast: false
reactant: 428195
name: cAMP4_R2C_PKA_binding
is version of: GO:0034237
is version of: GO:0034236
product: 428219
reactant: 428207
reversible: false
type: Reaction
kinetic law: 428231

426055
value: 40.0
name: koff23
type: LocalParameter

427882
value: 7.5E7
name: kon39
type: LocalParameter

metaid_0000123
has only substance units: false
has part: IPR015655
in compartment: metaid_0000003
initial concentration: 0.0
initial amount: NaN
has part: Q9UD71
boundary condition: false
name: D34:137_PP2C
type: Species
constant: false

423659
stoichiometry: 1.0
species: metaid_0000066
type: SpeciesReference

metaid_0000153
kinetic law: 427509
product: 427497
reactant: 427485
reactant: 427473
is version of: GO:0005509
fast: false
reversible: false
name: PP2Binactive_Ca_binding
type: Reaction

metaid_0000028
initial amount: NaN
has only substance units: false
type: Species
has part: Q99PS2
has part: Q9UD71
initial concentration: 0.0
boundary condition: false
in compartment: metaid_0000003
name: D34_CK1
constant: false

428087
stoichiometry: 1.0
species: metaid_0000164
type: SpeciesReference

426187
stoichiometry: 1.0
species: metaid_0000119
type: SpeciesReference

424452
stoichiometry: 1.0
species: metaid_0000083
type: SpeciesReference

428378
stoichiometry: 1.0
species: metaid_0000174
type: SpeciesReference

427545
stoichiometry: 2.0
species: metaid_0000154
type: SpeciesReference

metaid_0000174
initial concentration: 0.0
constant: false
has part: CHEBI:17489
has part: PIRSF000582
in compartment: metaid_0000003
type: Species
boundary condition: false
initial amount: NaN
has part: PIRSF000548
name: cAMP4_R2C
has only substance units: false
is version of: GO:0043234

427088
stoichiometry: 1.0
species: metaid_0000145
type: SpeciesReference

424656
value: 1.0E7
name: kon17
type: LocalParameter

metaid_0000100
product: 425232
is version of: http://identifiers.org/ec-code/3.1.3.16
reversible: false
is version of: GO:0004722
kinetic law: 425244
fast: false
reactant: 425208
type: Reaction
name: D34:75_dephospho_by_PP2A_on_75
product: 425220

426271
stoichiometry: 1.0
species: metaid_0000123
type: SpeciesReference

424992
stoichiometry: 1.0
species: metaid_0000094
type: SpeciesReference

metaid_0000120
kinetic law: 426163
product: 426151
reactant: 426139
reactant: 426127
is version of: GO:0051721
fast: false
reversible: false
name: D34:75:137_PP2AP_binding
type: Reaction

427028
stoichiometry: 1.0
species: metaid_0000019
type: SpeciesReference

422624
stoichiometry: 1.0
species: metaid_0000028
type: SpeciesReference

metaid_0000154
is: CHEBI:29108
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: metaid_0000003
name: Ca
type: Species

metaid_0000029
is version of: PIRSF000911
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: metaid_0000003
name: PP2B
type: Species

426235
value: 40.0
name: koff26
type: LocalParameter

metaid_0000175
kinetic law: 428293
product: 428281
product: 428268
reactant: 428255
fast: false
reversible: false
name: cAMP4_R2C2_PKA_unbinding
type: Reaction

metaid_0000101
kinetic law: 425304
product: 425292
product: 425280
reactant: 425268
fast: false
reversible: false
name: D34:75_PP2A_unbinding
type: Reaction

429029
persistant: true
initial value: true
type: Trigger

423034
value: 1.7E7
name: kon10
type: LocalParameter

425510
stoichiometry: 1.0
species: metaid_0000080
type: SpeciesReference

426800
stoichiometry: 1.0
species: metaid_0000029
type: SpeciesReference

424079
stoichiometry: 1.0
species: metaid_0000014
type: SpeciesReference

429365
persistant: true
initial value: true
type: Trigger

metaid_0000121
kinetic law: 426223
product: 426211
product: 426199
reactant: 426187
fast: false
reversible: false
name: D34:75:137_PP2AP_unbinding
type: Reaction

metaid_0000155
type: Species
has only substance units: false
constant: false
name: PP2BinactiveCa2
in compartment: metaid_0000003
initial amount: NaN
boundary condition: false
initial concentration: 0.0
is version of: PIRSF000911
is version of: CHEBI:29108

426595
value: 12.0
name: koff24
type: LocalParameter

metaid_0000023
is version of: Q9UD71
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: metaid_0000003
name: D34
type: Species

metaid_0000176
reactant: 428330
reversible: false
type: Reaction
kinetic law: 428354
fast: false
is version of: GO:0034236
is version of: GO:0034237
product: 428342
reactant: 428317
name: cAMP4_R2_PKA_binding

metaid_0000003
is version of: GO:0043197
constant: true
size: 1.0E-15
spatial dimensions: 3.0
name: Spine
type: Compartment

427617
stoichiometry: 2.0
species: metaid_0000154
type: SpeciesReference

425947
stoichiometry: 1.0
species: metaid_0000115
type: SpeciesReference

424259
stoichiometry: 1.0
species: metaid_0000034
type: SpeciesReference

421856
stoichiometry: 1.0
species: metaid_0000007
type: SpeciesReference

428305
value: 60.0
name: koff41
type: LocalParameter

metaid_0000126
has only substance units: false
initial amount: NaN
boundary condition: false
type: Species
constant: false
has part: Q9UD71
has part: IPR015655
name: D75:137_PP2C
in compartment: metaid_0000003
initial concentration: 0.0

426607
stoichiometry: 1.0
species: metaid_0000080
type: SpeciesReference

metaid_0000127
is version of: IPR000396
constant: false
boundary condition: false
has only substance units: false
initial concentration: 2.0E-6
initial amount: NaN
in compartment: metaid_0000003
name: PDE
type: Species

427581
value: 3.0E15
name: kon36
type: LocalParameter

426031
stoichiometry: 1.0
species: metaid_0000049
type: SpeciesReference

423635
value: 5600000.0
name: kon12
type: LocalParameter

metaid_0000177
name: cAMP4_R2
boundary condition: false
initial amount: NaN
is version of: GO:0043234
is version of: CHEBI:17489
initial concentration: 0.0
constant: false
type: Species
has only substance units: false
in compartment: metaid_0000003
is version of: PIRSF000548

metaid_0000024
product: 422228
name: D_Phospho_by_PKA_on_34
reversible: false
is version of: http://identifiers.org/ec-code/2.7.11.11
product: 422216
type: Reaction
fast: false
reactant: 422204
kinetic law: 422240
is version of: GO:0004691

426956
value: 6.0
name: kcat29
type: LocalParameter

metaid_0000004
is version of: Q9UD71
constant: false
boundary condition: false
has only substance units: false
initial concentration: 4.98E-6
initial amount: NaN
in compartment: metaid_0000003
name: D
type: Species

427702
value: 1.0
name: koff36
type: LocalParameter

metaid_0000025
type: Species
initial concentration: 0.0
initial amount: NaN
boundary condition: false
has part: Q03114
in compartment: metaid_0000003
name: D34_CDK5
has only substance units: false
has part: Q9UD71
constant: false

metaid_0000178
kinetic law: 428414
product: 428402
product: 428390
reactant: 428378
fast: false
reversible: false
name: cAMP4_R2C_PKA_unbinding
type: Reaction

425292
stoichiometry: 1.0
species: metaid_0000045
type: SpeciesReference

424319
stoichiometry: 1.0
species: metaid_0000080
type: SpeciesReference

metaid_0000005
is: Q03114
constant: false
boundary condition: false
has only substance units: false
initial concentration: 2.0E-7
initial amount: NaN
in compartment: metaid_0000003
name: CDK5
type: Species

metaid_0000150
kinetic law: 427341
product: 427329
product: 427317
reactant: 427305
fast: false
reversible: false
name: PP2A_PKA_unbinding
type: Reaction

427064
value: 6000000.0
name: kon31
type: LocalParameter

metaid_0000124
product: 426331
name: D34:137_dephospho_by_PP2C_on_137
reversible: false
type: Reaction
is version of: GO:0004722
product: 426319
is version of: http://identifiers.org/ec-code/3.1.3.16
fast: false
reactant: 426307
kinetic law: 426343

424956
value: 0.12
name: koff19
type: LocalParameter

425534
stoichiometry: 1.0
species: metaid_0000107
type: SpeciesReference

423671
stoichiometry: 1.0
species: metaid_0000065
type: SpeciesReference

423707
stoichiometry: 1.0
species: metaid_0000061
type: SpeciesReference

metaid_0000179
kinetic law: 428474
product: 428462
reactant: 428450
reactant: 428438
is version of: GO:0030552
fast: false
reversible: false
name: cAMP_PDE_binding
type: Reaction

425498
value: 24.0
name: koff22
type: LocalParameter

423587
stoichiometry: 1.0
species: metaid_0000018
type: SpeciesReference

426571
stoichiometry: 1.0
species: metaid_0000066
type: SpeciesReference

metaid_0000026
kinetic law: 422300
product: 422288
reactant: 422276
reactant: 422264
is version of: GO:0019901
fast: false
reversible: false
name: D34_CDK5_binding
type: Reaction

metaid_0000006
boundary condition: false
has part: Q9UD71
in compartment: metaid_0000003
initial amount: NaN
constant: false
has only substance units: false
type: Species
initial concentration: 0.0
name: D_CDK5
has part: Q03114

422084
stoichiometry: 1.0
species: metaid_0000004
type: SpeciesReference

422384
stoichiometry: 1.0
species: metaid_0000023
type: SpeciesReference

metaid_0000190
constant: true
boundary condition: true
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: metaid_0000003
name: Empty
type: Species

425220
stoichiometry: 1.0
species: metaid_0000023
type: SpeciesReference

metaid_0000125
kinetic law: 426403
product: 426391
product: 426379
reactant: 426367
fast: false
reversible: false
name: D34:137_PP2C_unbinding
type: Reaction

metaid_0000151
reactant: 427365
product: 427389
type: Reaction
is version of: GO:0004691
fast: false
reversible: false
product: 427377
kinetic law: 427401
is version of: http://identifiers.org/ec-code/2.7.11.11
name: PP2A_phospho_by_PKA

422216
stoichiometry: 1.0
species: metaid_0000023
type: SpeciesReference

427654
stoichiometry: 1.0
species: metaid_0000029
type: SpeciesReference

425838
stoichiometry: 1.0
species: metaid_0000034
type: SpeciesReference

426559
stoichiometry: 1.0
species: metaid_0000053
type: SpeciesReference

428572
stoichiometry: 1.0
species: metaid_0000183
type: SpeciesReference

423875
value: 10.8
name: koff12
type: LocalParameter

423371
stoichiometry: 1.0
species: metaid_0000045
type: SpeciesReference

422852
value: 4400000.0
name: kon7
type: LocalParameter

427726
stoichiometry: 1.0
species: metaid_0000161
type: SpeciesReference

metaid_0000007
is version of: Q9UD71
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: metaid_0000003
name: D75
type: Species

424848
stoichiometry: 1.0
species: metaid_0000091
type: SpeciesReference

426932
stoichiometry: 1.0
species: metaid_0000029
type: SpeciesReference

metaid_0000048
kinetic law: 423021
product: 423009
reactant: 422997
reactant: 422985
is version of: GO:0051721
fast: false
reversible: false
name: D75_PP2AP_binding
type: Reaction

metaid_0000255
event assignment: 429257
trigger: 429245
use values from trigger time: true
name: ca_off5
type: Event

425778
stoichiometry: 1.0
species: metaid_0000023
type: SpeciesReference

426872
stoichiometry: 1.0
species: metaid_0000029
type: SpeciesReference

421748
stoichiometry: 1.0
species: metaid_0000006
type: SpeciesReference

metaid_0000236
constant: false
value: 2.5E-8
name: ca_in
type: Parameter

422864
stoichiometry: 1.0
species: metaid_0000007
type: SpeciesReference

424031
stoichiometry: 1.0
species: metaid_0000066
type: SpeciesReference

424235
value: 12.0
name: koff18
type: LocalParameter

metaid_0000008
kinetic law: 421760
product: 421748
reactant: 421736
reactant: 421724
is version of: GO:0019901
fast: false
reversible: false
name: D_CDK5_binding
type: Reaction

425690
value: 24.0
name: koff25
type: LocalParameter

metaid_0000256
event assignment: 429281
trigger: 429269
use values from trigger time: true
name: ca_off6
type: Event

424860
stoichiometry: 1.0
species: metaid_0000018
type: SpeciesReference

metaid_0000047
has only substance units: false
name: D75_PP2A
boundary condition: false
has part: Q9UD71
has part: IPR006186
in compartment: metaid_0000003
constant: false
initial amount: NaN
initial concentration: 0.0
type: Species

428644
stoichiometry: 1.0
species: metaid_0000185
type: SpeciesReference

424608
stoichiometry: 1.0
species: metaid_0000034
type: SpeciesReference

metaid_0000108
name: D34:75:137_dephospho_by_PP2A_on_75
type: Reaction
product: 425585
kinetic law: 425611
is version of: http://identifiers.org/ec-code/3.1.3.16
fast: false
reactant: 425573
is version of: GO:0004722
reversible: false
product: 425598

421808
stoichiometry: 1.0
species: metaid_0000005
type: SpeciesReference

427678
stoichiometry: 2.0
species: metaid_0000154
type: SpeciesReference

423118
stoichiometry: 1.0
species: metaid_0000014
type: SpeciesReference

423479
stoichiometry: 1.0
species: metaid_0000007
type: SpeciesReference

425438
value: 10.0
name: kcat22
type: LocalParameter

427978
stoichiometry: 1.0
species: metaid_0000161
type: SpeciesReference

426848
stoichiometry: 1.0
species: metaid_0000138
type: SpeciesReference

metaid_0000128
is version of: PIRSF000911
constant: false
boundary condition: false
has only substance units: false
initial concentration: 3.32E-7
initial amount: NaN
in compartment: metaid_0000003
name: PP2Binactive
type: Species

metaid_0000253
event assignment: 429209
trigger: 429197
use values from trigger time: true
name: ca_off3
type: Event

422924
stoichiometry: 1.0
species: metaid_0000007
type: SpeciesReference

424271
stoichiometry: 1.0
species: metaid_0000014
type: SpeciesReference

metaid_0000109
kinetic law: 425677
product: 425664
product: 425650
reactant: 425637
fast: false
reversible: false
name: D34:75:137_PP2A_unbinding
type: Reaction

423167
stoichiometry: 1.0
species: metaid_0000043
type: SpeciesReference

427040
stoichiometry: 1.0
species: metaid_0000143
type: SpeciesReference

422276
stoichiometry: 1.0
species: metaid_0000005
type: SpeciesReference

425389
stoichiometry: 1.0
species: metaid_0000103
type: SpeciesReference

metaid_0000049
is version of: IPR006186
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: metaid_0000003
name: PP2AP
type: Species

427269
stoichiometry: 1.0
species: metaid_0000149
type: SpeciesReference

metaid_0000129
kinetic law: 426463
product: 426451
reactant: 426439
reactant: 426427
is version of: GO:0019903
fast: false
reversible: false
name: D75:137_PP2C_binding
type: Reaction

metaid_0000254
event assignment: 429233
trigger: 429221
use values from trigger time: true
name: ca_off4
type: Event

423767
stoichiometry: 1.0
species: metaid_0000061
type: SpeciesReference

428063
value: 33.0
name: koff38
type: LocalParameter

421796
stoichiometry: 1.0
species: metaid_0000004
type: SpeciesReference

426896
value: 24.0
name: koff29
type: LocalParameter

metaid_0000106
kinetic law: 425547
product: 425534
reactant: 425522
reactant: 425510
is version of: GO:0051721
fast: false
reversible: false
name: D34:75:137_PP2A_binding
type: Reaction

metaid_0000259
event assignment: 429353
trigger: 429341
use values from trigger time: true
name: ca_off9
type: Event

428620
stoichiometry: 1.0
species: metaid_0000161
type: SpeciesReference

422949
stoichiometry: 1.0
species: metaid_0000047
type: SpeciesReference

427245
stoichiometry: 1.0
species: metaid_0000045
type: SpeciesReference

425814
value: 24.0
name: kcat16
type: LocalParameter

425088
stoichiometry: 1.0
species: metaid_0000094
type: SpeciesReference

426535
value: 3.0
name: kcat24
type: LocalParameter

428438
stoichiometry: 1.0
species: metaid_0000161
type: SpeciesReference

425316
value: 24.0
name: koff15
type: LocalParameter

423851
stoichiometry: 1.0
species: metaid_0000019
type: SpeciesReference

423395
value: 24.0
name: koff9
type: LocalParameter

425160
stoichiometry: 1.0
species: metaid_0000045
type: SpeciesReference

metaid_0000107
has part: IPR006186
has only substance units: false
in compartment: metaid_0000003
type: Species
initial concentration: 0.0
boundary condition: false
name: D34:75:137_PP2A
has part: Q9UD71
constant: false
initial amount: NaN

426091
stoichiometry: 1.0
species: metaid_0000049
type: SpeciesReference

424788
stoichiometry: 1.0
species: metaid_0000037
type: SpeciesReference

421724
stoichiometry: 1.0
species: metaid_0000004
type: SpeciesReference

422888
stoichiometry: 1.0
species: metaid_0000043
type: SpeciesReference

425754
value: 1.7E7
name: kon16
type: LocalParameter

424055
value: 12.0
name: koff13
type: LocalParameter

428486
value: 2520000.0
name: kon44
type: LocalParameter

422324
stoichiometry: 1.0
species: metaid_0000023
type: SpeciesReference

424211
stoichiometry: 1.0
species: metaid_0000005
type: SpeciesReference

427954
stoichiometry: 1.0
species: metaid_0000162
type: SpeciesReference

423455
value: 24.0
name: kcat10
type: LocalParameter

429004
persistant: true
initial value: true
type: Trigger

422252
value: 2.7
name: kcat3
type: LocalParameter

427521
value: 1.0E15
name: kon35
type: LocalParameter

425716
stoichiometry: 1.0
species: metaid_0000049
type: SpeciesReference

metaid_0000257
event assignment: 429305
trigger: 429293
use values from trigger time: true
name: ca_off7
type: Event

metaid_0000170
kinetic law: 428051
product: 428038
product: 428026
reactant: 428014
fast: false
reversible: false
name: cAMP2_R2C2_unbinding
type: Reaction

metaid_0000104
product: 425413
product: 425401
reversible: false
is version of: GO:0004722
reactant: 425389
name: D75:137_dephospho_by_PP2A_on_75
type: Reaction
kinetic law: 425426
is version of: http://identifiers.org/ec-code/3.1.3.16
fast: false

428680
stoichiometry: 1.0
species: metaid_0000185
type: SpeciesReference

423058
stoichiometry: 1.0
species: metaid_0000007
type: SpeciesReference

425028
stoichiometry: 1.0
species: metaid_0000094
type: SpeciesReference

425401
stoichiometry: 1.0
species: metaid_0000018
type: SpeciesReference

metaid_0000105
kinetic law: 425486
product: 425474
product: 425462
reactant: 425450
fast: false
reversible: false
name: D75:137_PP2A_unbinding
type: Reaction

422648
stoichiometry: 1.0
species: metaid_0000014
type: SpeciesReference

metaid_0000171
kinetic law: 428111
product: 428099
product: 428087
reactant: 428075
fast: false
reversible: false
name: cAMP3_R2C2_unbinding
type: Reaction

metaid_0000258
event assignment: 429329
trigger: 429317
use values from trigger time: true
name: ca_off8
type: Event

424560
stoichiometry: 1.0
species: metaid_0000053
type: SpeciesReference

425353
stoichiometry: 1.0
species: metaid_0000103
type: SpeciesReference

428812
stoichiometry: 1.0
species: metaid_0000154
type: SpeciesReference

426295
value: 7500000.0
name: kon20
type: LocalParameter

metaid_0000260
event assignment: 429377
trigger: 429365
use values from trigger time: true
name: ca_off10
type: Event

metaid_0000051
kinetic law: 423082
product: 423070
product: 423058
reactant: 423046
fast: false
reversible: false
name: D75_CK1_unbinding
type: Reaction

427894
stoichiometry: 1.0
species: metaid_0000165
type: SpeciesReference

426655
value: 7500000.0
name: kon28
type: LocalParameter

421892
value: 3.0
name: kcat1
type: LocalParameter

422708
stoichiometry: 1.0
species: metaid_0000029
type: SpeciesReference

metaid_0000079
kinetic law: 424343
product: 424331
product: 424319
reactant: 424307
is version of: http://identifiers.org/ec-code/2.7.11.1
fast: false
reversible: false
name: D34:75_phospho_by_CK1_on_137
type: Reaction

422732
value: 4.0
name: kcat6
type: LocalParameter

427161
stoichiometry: 1.0
species: metaid_0000019
type: SpeciesReference

metaid_0000240
event assignment: 428896
trigger: 428884
use values from trigger time: true
name: cAMP_pulse
type: Event

422432
value: 1.0E7
name: kon6
type: LocalParameter

422985
stoichiometry: 1.0
species: metaid_0000007
type: SpeciesReference

426439
stoichiometry: 1.0
species: metaid_0000066
type: SpeciesReference

metaid_0000052
kinetic law: 423143
product: 423130
product: 423118
reactant: 423106
is version of: http://identifiers.org/ec-code/2.7.11.1
fast: false
reversible: false
name: D75_Phospho_by_CK1_on_137
type: Reaction

429101
persistant: true
initial value: true
type: Trigger

423947
stoichiometry: 1.0
species: metaid_0000065
type: SpeciesReference

424716
value: 1600.0
name: koff17
type: LocalParameter

423347
stoichiometry: 1.0
species: metaid_0000047
type: SpeciesReference

422048
stoichiometry: 1.0
species: metaid_0000014
type: SpeciesReference

426499
stoichiometry: 1.0
species: metaid_0000007
type: SpeciesReference

422192
value: 10.8
name: koff3
type: LocalParameter

427858
stoichiometry: 1.0
species: metaid_0000165
type: SpeciesReference

425995
value: 24.0
name: kcat23
type: LocalParameter

424091
stoichiometry: 1.0
species: metaid_0000074
type: SpeciesReference

422792
value: 16.0
name: koff6
type: LocalParameter

428183
value: 32.5
name: koff40
type: LocalParameter

metaid_0000053
is version of: Q9UD71
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: metaid_0000003
name: D75:137
type: Species

426715
value: 3.0
name: kcat28
type: LocalParameter

428980
persistant: true
initial value: true
type: Trigger

427209
stoichiometry: 1.0
species: metaid_0000127
type: SpeciesReference

422132
value: 5600000.0
name: kon3
type: LocalParameter

424007
stoichiometry: 1.0
species: metaid_0000065
type: SpeciesReference

425256
value: 10.0
name: kcat15
type: LocalParameter

metaid_0000054
kinetic law: 423203
product: 423191
product: 423179
reactant: 423167
is version of: http://identifiers.org/ec-code/2.7.11.11
fast: false
reversible: false
name: D75_Phospho_by_PKA_on_34
type: Reaction

425462
stoichiometry: 1.0
species: metaid_0000053
type: SpeciesReference

424800
stoichiometry: 1.0
species: metaid_0000029
type: SpeciesReference

426127
stoichiometry: 1.0
species: metaid_0000080
type: SpeciesReference

424151
stoichiometry: 1.0
species: metaid_0000076
type: SpeciesReference

427485
stoichiometry: 2.0
species: metaid_0000154
type: SpeciesReference

424175
value: 5600000.0
name: kon18
type: LocalParameter

422456
stoichiometry: 1.0
species: metaid_0000023
type: SpeciesReference

428450
stoichiometry: 1.0
species: metaid_0000127
type: SpeciesReference

metaid_0000264
constant: true
value: 2.0
name: spike_duration
type: Parameter

metaid_0000055
kinetic law: 423263
product: 423251
product: 423239
reactant: 423227
fast: false
reversible: false
name: D75_PKA_unbinding
type: Reaction

422816
stoichiometry: 1.0
species: metaid_0000014
type: SpeciesReference

428268
stoichiometry: 1.0
species: metaid_0000174
type: SpeciesReference

425886
stoichiometry: 1.0
species: metaid_0000053
type: SpeciesReference

422756
stoichiometry: 1.0
species: metaid_0000023
type: SpeciesReference

425573
stoichiometry: 1.0
species: metaid_0000107
type: SpeciesReference

424752
stoichiometry: 1.0
species: metaid_0000029
type: SpeciesReference

metaid_0000075
kinetic law: 424163
product: 424151
reactant: 424139
reactant: 424127
is version of: GO:0019901
fast: false
reversible: false
name: D34:137_CDK5_binding
type: Reaction

426679
stoichiometry: 1.0
species: metaid_0000034
type: SpeciesReference

metaid_0000263
constant: true
value: 6.6E-6
name: kon_high
type: Parameter

metaid_0000056
type: Reaction
reversible: false
is version of: GO:0004722
product: 423299
reactant: 423287
kinetic law: 423323
name: D75_dephospho_by_PP2A
is version of: http://identifiers.org/ec-code/3.1.3.16
product: 423311
fast: false

425971
stoichiometry: 1.0
species: metaid_0000049
type: SpeciesReference

428752
stoichiometry: 1.0
species: metaid_0000183
type: SpeciesReference

427317
stoichiometry: 1.0
species: metaid_0000045
type: SpeciesReference

423239
stoichiometry: 1.0
species: metaid_0000007
type: SpeciesReference

429125
persistant: true
initial value: true
type: Trigger

metaid_0000076
boundary condition: false
has only substance units: false
has part: Q03114
type: Species
name: D34:137_CDK5
has part: Q9UD71
initial amount: NaN
initial concentration: 0.0
in compartment: metaid_0000003
constant: false

422528
stoichiometry: 1.0
species: metaid_0000005
type: SpeciesReference

metaid_0000262
constant: true
value: 50.0
name: cAMP_Ca_delay
type: Parameter

425232
stoichiometry: 1.0
species: metaid_0000045
type: SpeciesReference

metaid_0000057
kinetic law: 423383
product: 423371
product: 423359
reactant: 423347
fast: false
reversible: false
name: D75_PP2A_unbinding
type: Reaction

427425
stoichiometry: 1.0
species: metaid_0000049
type: SpeciesReference

428668
value: 5040000.0
name: kon45
type: LocalParameter

426019
stoichiometry: 1.0
species: metaid_0000053
type: SpeciesReference

426740
stoichiometry: 1.0
species: metaid_0000080
type: SpeciesReference

423539
stoichiometry: 1.0
species: metaid_0000005
type: SpeciesReference

425703
stoichiometry: 1.0
species: metaid_0000034
type: SpeciesReference

426475
value: 7500000.0
name: kon24
type: LocalParameter

metaid_0000077
kinetic law: 424223
product: 424211
product: 424199
reactant: 424187
fast: false
reversible: false
name: D34:137_CDK5_unbinding
type: Reaction

427461
value: 5.0
name: kcat34
type: LocalParameter

metaid_0000058
name: D75_dephospho_by_PP2AP
product: 423419
product: 423431
fast: false
reactant: 423407
is version of: http://identifiers.org/ec-code/3.1.3.16
is version of: GO:0004722
kinetic law: 423443
reversible: false
type: Reaction

424199
stoichiometry: 1.0
species: metaid_0000037
type: SpeciesReference

427377
stoichiometry: 1.0
species: metaid_0000049
type: SpeciesReference

metaid_0000261
constant: true
value: 400.0
name: cAMP_delay
type: Parameter

425148
stoichiometry: 1.0
species: metaid_0000034
type: SpeciesReference

425040
stoichiometry: 1.0
species: metaid_0000080
type: SpeciesReference

424115
value: 4400000.0
name: kon14
type: LocalParameter

422156
stoichiometry: 1.0
species: metaid_0000004
type: SpeciesReference

metaid_0000078
kinetic law: 424283
product: 424271
product: 424259
reactant: 424247
fast: false
reversible: false
name: D34:75_CK1_unbinding
type: Reaction

BIOMD0000000152
reaction: metaid_0000146
reaction: metaid_0000125
species: metaid_0000145
reaction: metaid_0000067
reaction: metaid_0000100
event: metaid_0000244
species: metaid_0000161
reaction: metaid_0000070
species: metaid_0000049
reaction: metaid_0000036
reaction: metaid_0000178
reaction: metaid_0000153
reaction: metaid_0000147
species: metaid_0000018
reaction: metaid_0000089
reaction: metaid_0000122
reaction: metaid_0000068
reaction: metaid_0000101
event: metaid_0000245
species: metaid_0000066
reaction: metaid_0000085
species: metaid_0000137
reaction: metaid_0000017
species: metaid_0000025
reaction: metaid_0000012
reaction: metaid_0000175
event: metaid_0000251
species: metaid_0000174
reaction: metaid_0000051
event: metaid_0000241
reaction: metaid_0000171
species: metaid_0000190
species: metaid_0000005
species: metaid_0000133
reaction: metaid_0000129
species: metaid_0000154
reaction: metaid_0000044
event: metaid_0000256
species: metaid_0000138
reaction: metaid_0000013
reaction: metaid_0000027
curated: true
reaction: metaid_0000159
reaction: metaid_0000130
species: metaid_0000074
reaction: metaid_0000139
has part: GO:0007212
species: metaid_0000006
species: metaid_0000166
reaction: metaid_0000113
reaction: metaid_0000173
area units: metaid_0000005
reaction: metaid_0000105
reaction: metaid_0000062
reaction: metaid_0000096
species: metaid_0000034
species: metaid_0000162
reaction: metaid_0000135
species: metaid_0000126
species: metaid_0000050
reaction: metaid_0000114
occurs in: http://identifiers.org/taxonomy/9606
species: metaid_0000014
reaction: metaid_0000042
reaction: metaid_0000056
species: metaid_0000087
reaction: metaid_0000156
species: metaid_0000030
species: metaid_0000019
reaction: metaid_0000167
reaction: metaid_0000142
species: metaid_0000127
species: metaid_0000083
event: metaid_0000259
reaction: metaid_0000078
reaction: metaid_0000057
reaction: metaid_0000150
reaction: metaid_0000117
reaction: metaid_0000032
species: metaid_0000107

423899
stoichiometry: 1.0
species: metaid_0000037
type: SpeciesReference

426788
stoichiometry: 1.0
species: metaid_0000137
type: SpeciesReference

423215
value: 0.0
name: kcat8
type: LocalParameter

429149
persistant: true
initial value: true
type: Trigger

metaid_0000071
type: Reaction
name: D137_dephospho_by_PP2C
reversible: false
product: 423959
is version of: GO:0004722
kinetic law: 423983
fast: false
product: 423971
reactant: 423947
is version of: http://identifiers.org/ec-code/3.1.3.16

422504
stoichiometry: 1.0
species: metaid_0000025
type: SpeciesReference

423815
value: 3.0
name: kcat11
type: LocalParameter

metaid_0000169
kinetic law: 427990
product: 427978
product: 427966
reactant: 427954
fast: false
reversible: false
name: cAMP_R2C2_unbinding
type: Reaction

428159
stoichiometry: 1.0
species: metaid_0000161
type: SpeciesReference

metaid_0000149
constant: false
has part: IPR006186
boundary condition: false
initial amount: NaN
has part: PIRSF000582
has only substance units: false
in compartment: metaid_0000003
initial concentration: 0.0
name: PP2A_PKA
type: Species

metaid_0000032
kinetic law: 422480
product: 422468
product: 422456
reactant: 422444
is version of: GO:0019901
fast: false
reversible: false
name: D34_CDK5_unbinding
type: Reaction

424512
stoichiometry: 1.0
species: metaid_0000019
type: SpeciesReference

424932
stoichiometry: 1.0
species: metaid_0000029
type: SpeciesReference

428243
value: 1.8E7
name: kon41
type: LocalParameter

425598
stoichiometry: 1.0
species: metaid_0000045
type: SpeciesReference

metaid_0000072
kinetic law: 424043
product: 424031
product: 424019
reactant: 424007
fast: false
reversible: false
name: D137_PP2C_unbinding
type: Reaction

427149
stoichiometry: 1.0
species: metaid_0000127
type: SpeciesReference

metaid_0000148
kinetic law: 427281
product: 427269
reactant: 427257
reactant: 427245
is version of: GO:0034236
fast: false
reversible: false
name: PP2A_PKA_binding
type: Reaction

metaid_0000168
fast: false
product: 427918
name: cAMP3_R2C2_binding_by_cAMP
is version of: GO:0034237
reactant: 427906
type: Reaction
reversible: false
reactant: 427894
is version of: GO:0030552
kinetic law: 427930

424427
stoichiometry: 1.0
species: metaid_0000053
type: SpeciesReference

metaid_0000031
kinetic law: 422420
product: 422408
reactant: 422396
reactant: 422384
is version of: GO:0030346
fast: false
reversible: false
name: D34_PP2B_binding
type: Reaction

427293
value: 1.0E7
name: kon33
type: LocalParameter

425650
stoichiometry: 1.0
species: metaid_0000080
type: SpeciesReference

424139
stoichiometry: 1.0
species: metaid_0000005
type: SpeciesReference

metaid_0000073
kinetic law: 424103
product: 424091
reactant: 424079
reactant: 424067
is version of: GO:0019901
fast: false
reversible: false
name: D34:75_CK1_binding
type: Reaction

428884
persistant: true
initial value: true
type: Trigger

metaid_0000034
is version of: Q9UD71
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: metaid_0000003
name: D34:75
type: Species

423611
stoichiometry: 1.0
species: metaid_0000063
type: SpeciesReference

424680
stoichiometry: 1.0
species: metaid_0000034
type: SpeciesReference

427353
value: 16.0
name: koff33
type: LocalParameter

426367
stoichiometry: 1.0
species: metaid_0000123
type: SpeciesReference

423515
value: 40.0
name: koff10
type: LocalParameter

427762
value: 5.4E7
name: kon37
type: LocalParameter

421832
value: 12.0
name: koff1
type: LocalParameter

426451
stoichiometry: 1.0
species: metaid_0000126
type: SpeciesReference

metaid_0000074
in compartment: metaid_0000003
has part: Q9UD71
initial concentration: 0.0
initial amount: NaN
has only substance units: false
name: D34:75_CK1
boundary condition: false
type: Species
has part: Q99PS2
constant: false

426307
stoichiometry: 1.0
species: metaid_0000123
type: SpeciesReference

metaid_0000033
product: 422516
name: D34_Phospho_by_CDK5_on_75
is version of: GO:0004693
kinetic law: 422540
is version of: http://identifiers.org/ec-code/2.7.11.22
type: Reaction
fast: false
reversible: false
product: 422528
reactant: 422504

424620
stoichiometry: 1.0
species: metaid_0000029
type: SpeciesReference

422564
stoichiometry: 1.0
species: metaid_0000028
type: SpeciesReference

423287
stoichiometry: 1.0
species: metaid_0000047
type: SpeciesReference

428135
stoichiometry: 1.0
species: metaid_0000166
type: SpeciesReference

427786
stoichiometry: 1.0
species: metaid_0000161
type: SpeciesReference

metaid_0000145
is version of: IPR000396
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: metaid_0000003
name: PDEP
type: Species

423791
stoichiometry: 1.0
species: metaid_0000005
type: SpeciesReference

429341
persistant: true
initial value: true
type: Trigger

427834
stoichiometry: 1.0
species: metaid_0000164
type: SpeciesReference

424536
value: 0.0
name: kcat21
type: LocalParameter

424476
value: 5600000.0
name: kon21
type: LocalParameter

metaid_0000131
kinetic law: 426583
product: 426571
product: 426559
reactant: 426547
fast: false
reversible: false
name: D75:137_PP2C_unbinding
type: Reaction

426259
stoichiometry: 1.0
species: metaid_0000066
type: SpeciesReference

422024
stoichiometry: 1.0
species: metaid_0000015
type: SpeciesReference

423839
stoichiometry: 1.0
species: metaid_0000018
type: SpeciesReference

421916
stoichiometry: 1.0
species: metaid_0000014
type: SpeciesReference

423009
stoichiometry: 1.0
species: metaid_0000050
type: SpeciesReference

metaid_0000144
type: Reaction
product: 427101
fast: false
product: 427088
kinetic law: 427113
is version of: GO:0004691
reversible: false
reactant: 427076
is version of: http://identifiers.org/ec-code/2.7.11.11
name: PDE_phospho_by_PKA

425100
stoichiometry: 1.0
species: metaid_0000053
type: SpeciesReference

427185
value: 36.0
name: koff31
type: LocalParameter

metaid_0000130
reactant: 426487
kinetic law: 426523
is version of: http://identifiers.org/ec-code/3.1.3.16
product: 426511
name: D75:137_dephospho_by_PP2C_137
reversible: false
fast: false
type: Reaction
is version of: GO:0004722
product: 426499

421784
stoichiometry: 1.0
species: metaid_0000006
type: SpeciesReference

426631
stoichiometry: 1.0
species: metaid_0000133
type: SpeciesReference

429053
persistant: true
initial value: true
type: Trigger

metaid_0000147
kinetic law: 427221
product: 427209
reactant: 427197
is version of: http://identifiers.org/ec-code/3.1.3.16
fast: false
reversible: false
name: PDEP_dephospho
type: Reaction

428848
stoichiometry: 1.0
species: metaid_0000190
type: SpeciesReference

422372
value: 4400000.0
name: kon5
type: LocalParameter

423551
stoichiometry: 1.0
species: metaid_0000061
type: SpeciesReference

metaid_0000030
has only substance units: false
in compartment: metaid_0000003
initial concentration: 0.0
type: Species
initial amount: NaN
boundary condition: false
has part: Q9UD71
has part: PIRSF000911
name: D34_PP2B
constant: false

428038
stoichiometry: 1.0
species: metaid_0000161
type: SpeciesReference

423070
stoichiometry: 1.0
species: metaid_0000014
type: SpeciesReference

metaid_0000070
kinetic law: 423923
product: 423911
product: 423899
reactant: 423887
is version of: http://identifiers.org/ec-code/2.7.11.11
fast: false
reversible: false
name: D137_phospho_by_PKA_on_34
type: Reaction

421988
stoichiometry: 1.0
species: metaid_0000014
type: SpeciesReference

metaid_0000146
kinetic law: 427173
product: 427161
product: 427149
reactant: 427137
fast: false
reversible: false
name: PDE_PKA_unbinding
type: Reaction

422588
stoichiometry: 1.0
species: metaid_0000014
type: SpeciesReference

metaid_0000050
type: Species
boundary condition: false
in compartment: metaid_0000003
initial concentration: 0.0
has only substance units: false
constant: false
has part: IPR006186
initial amount: NaN
has part: Q9UD71
name: D75_PP2AP

429077
persistant: true
initial value: true
type: Trigger

423407
stoichiometry: 1.0
species: metaid_0000050
type: SpeciesReference

426980
stoichiometry: 1.0
species: metaid_0000137
type: SpeciesReference

metaid_0000162
constant: false
has part: PIRSF000548
boundary condition: false
has part: CHEBI:17489
initial amount: NaN
initial concentration: 0.0
name: cAMP_R2C2
in compartment: metaid_0000003
type: Species
has part: PIRSF000582
has only substance units: false
is version of: GO:0043234

427076
stoichiometry: 1.0
species: metaid_0000143
type: SpeciesReference

metaid_0000183
is: CHEBI:16027
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: metaid_0000003
name: AMP
type: Species

426199
stoichiometry: 1.0
species: metaid_0000080
type: SpeciesReference

424307
stoichiometry: 1.0
species: metaid_0000074
type: SpeciesReference

427557
stoichiometry: 1.0
species: metaid_0000029
type: SpeciesReference

428366
value: 1.8E7
name: kon42
type: LocalParameter

427016
stoichiometry: 1.0
species: metaid_0000127
type: SpeciesReference

metaid_0000013
name: DPhospho_by_CDK5_on_75
is version of: GO:0004693
fast: false
is version of: http://identifiers.org/ec-code/2.7.11.22
kinetic law: 421880
reactant: 421844
reversible: false
product: 421856
type: Reaction
product: 421868

422636
stoichiometry: 1.0
species: metaid_0000037
type: SpeciesReference

metaid_0000142
kinetic law: 427052
product: 427040
reactant: 427028
reactant: 427016
is version of: GO:0034236
fast: false
reversible: false
name: PDE_PKA_binding
type: Reaction

metaid_0000098
in compartment: metaid_0000003
type: Species
name: D34:75_PP2A
initial concentration: 0.0
initial amount: NaN
constant: false
boundary condition: false
has only substance units: false
has part: IPR006186
has part: Q9UD71

425280
stoichiometry: 1.0
species: metaid_0000034
type: SpeciesReference

metaid_0000249
event assignment: 429137
trigger: 429125
use values from trigger time: true
name: ca_on9
type: Event

428692
stoichiometry: 1.0
species: metaid_0000161
type: SpeciesReference

423046
stoichiometry: 1.0
species: metaid_0000041
type: SpeciesReference

metaid_0000182
product: 428572
is version of: GO:0004112
type: Reaction
fast: false
is version of: GO:0006198
name: cAMP_PDE_degradation
product: 428584
reactant: 428560
reversible: false
kinetic law: 428596

422228
stoichiometry: 1.0
species: metaid_0000019
type: SpeciesReference

metaid_0000163
reactant: 427786
product: 427798
reactant: 427774
kinetic law: 427810
reversible: false
is version of: GO:0034237
fast: false
type: Reaction
name: cAMP_R2C2_binding_by_cAMP
is version of: GO:0030552

426247
stoichiometry: 1.0
species: metaid_0000037
type: SpeciesReference

metaid_0000014
is version of: Q99PS2
constant: false
boundary condition: false
has only substance units: false
initial concentration: 1.66E-7
initial amount: NaN
in compartment: metaid_0000003
name: CK1
type: Species

422096
stoichiometry: 1.0
species: metaid_0000019
type: SpeciesReference

metaid_0000097
fast: false
reactant: 425088
kinetic law: 425124
is version of: GO:0033192
is version of: http://identifiers.org/ec-code/3.1.3.16
type: Reaction
product: 425112
name: D34:75:137_dephospho_by_PP2B_on_34
reversible: false
product: 425100

metaid_0000143
has part: PIRSF000582
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: metaid_0000003
name: PDE_PKA
type: Species

423599
stoichiometry: 1.0
species: metaid_0000019
type: SpeciesReference

426812
stoichiometry: 1.0
species: metaid_0000138
type: SpeciesReference

427641
value: 1.0
name: koff35
type: LocalParameter

422336
stoichiometry: 1.0
species: metaid_0000014
type: SpeciesReference

425959
stoichiometry: 1.0
species: metaid_0000018
type: SpeciesReference

421868
stoichiometry: 1.0
species: metaid_0000005
type: SpeciesReference

metaid_0000160
has part: PIRSF000548
boundary condition: false
constant: false
initial amount: NaN
in compartment: metaid_0000003
has part: PIRSF000582
initial concentration: 6.64E-6
has only substance units: false
type: Species
is version of: GO:0043234
name: R2C2

428932
persistant: true
initial value: true
type: Trigger

424379
stoichiometry: 1.0
species: metaid_0000080
type: SpeciesReference

metaid_0000181
kinetic law: 428536
product: 428523
product: 428511
reactant: 428499
fast: false
reversible: false
name: cAMP_PDE_unbinding
type: Reaction

metaid_0000011
kinetic law: 421940
product: 421928
reactant: 421916
reactant: 421904
is version of: GO:0019901
fast: false
reversible: false
name: DCDK1_binding
type: Reaction

metaid_0000039
kinetic law: 422780
product: 422768
product: 422756
reactant: 422744
fast: false
reversible: false
name: D34_PP2B_unbinding
type: Reaction

421952
value: 4400000.0
name: kon2
type: LocalParameter

422396
stoichiometry: 1.0
species: metaid_0000029
type: SpeciesReference

metaid_0000110
kinetic law: 425742
product: 425729
reactant: 425716
reactant: 425703
is version of: GO:0051721
fast: false
reversible: false
name: D34:75_PP2AP_binding
type: Reaction

metaid_0000140
type: Reaction
is version of: http://identifiers.org/ec-code/3.1.3.16
product: 426920
reactant: 426908
name: CK1P_dephospho_by_PP2B
is version of: GO:0033192
product: 426932
kinetic law: 426944
reversible: false
fast: false

metaid_0000096
kinetic law: 425064
product: 425052
product: 425040
reactant: 425028
fast: false
reversible: false
name: D34:75:137_PP2B_unbinding
type: Reaction

426415
value: 12.0
name: koff20
type: LocalParameter

427125
value: 9.0
name: kcat31
type: LocalParameter

422696
stoichiometry: 1.0
species: metaid_0000004
type: SpeciesReference

metaid_0000161
is: CHEBI:17489
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: metaid_0000003
name: cAMP
type: Species

metaid_0000180
type: Species
in compartment: metaid_0000003
boundary condition: false
has part: IPR000396
constant: false
has part: CHEBI:17489
has only substance units: false
name: cAMP_PDE
initial concentration: 0.0
initial amount: NaN

422492
value: 12.0
name: koff4
type: LocalParameter

428026
stoichiometry: 1.0
species: metaid_0000162
type: SpeciesReference

425328
stoichiometry: 1.0
species: metaid_0000053
type: SpeciesReference

428426
value: 60.0
name: kon43
type: LocalParameter

423995
value: 3.0
name: kcat13
type: LocalParameter

metaid_0000141
kinetic law: 426992
product: 426980
reactant: 426968
is version of: http://identifiers.org/ec-code/2.7.11.1
fast: false
reversible: false
name: CK1_phosphorylation
type: Reaction

428099
stoichiometry: 1.0
species: metaid_0000161
type: SpeciesReference

metaid_0000012
kinetic law: 421820
product: 421808
product: 421796
reactant: 421784
fast: false
reversible: false
name: D_CDK5_unbinding
type: Reaction

429317
persistant: true
initial value: true
type: Trigger

426067
stoichiometry: 1.0
species: metaid_0000119
type: SpeciesReference

metaid_0000111
initial amount: NaN
constant: false
type: Species
has part: Q9UD71
name: D34:75_PP2AP
boundary condition: false
has part: IPR006186
in compartment: metaid_0000003
has only substance units: false
initial concentration: 0.0

425637
stoichiometry: 1.0
species: metaid_0000107
type: SpeciesReference

423647
stoichiometry: 1.0
species: metaid_0000018
type: SpeciesReference

metaid_0000095
kinetic law: 425004
product: 424992
reactant: 424980
reactant: 424968
is version of: GO:0030346
fast: false
reversible: false
name: D34:75:137_PP2B_binding
type: Reaction

metaid_0000037
is version of: Q9UD71
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: metaid_0000003
name: D34:137
type: Species

metaid_0000166
has part: CHEBI:17489
boundary condition: false
constant: false
has part: PIRSF000548
name: cAMP4_R2C2
is version of: GO:0043234
has only substance units: false
type: Species
initial concentration: 0.0
has part: PIRSF000582
initial amount: NaN
in compartment: metaid_0000003

metaid_0000017
kinetic law: 422000
product: 421988
product: 421976
reactant: 421964
fast: false
reversible: false
name: D_CDK1_unbinding
type: Reaction

428219
stoichiometry: 1.0
species: metaid_0000166
type: SpeciesReference

422612
value: 12.0
name: koff5
type: LocalParameter

424668
stoichiometry: 1.0
species: metaid_0000087
type: SpeciesReference

metaid_0000112
product: 425778
is version of: GO:0004722
type: Reaction
reversible: false
is version of: http://identifiers.org/ec-code/3.1.3.16
name: D34:75_dephospho_by_PP2AP_on_75
fast: false
reactant: 425766
product: 425790
kinetic law: 425802

metaid_0000094
name: D34:75:137_PP2B
has only substance units: false
has part: Q9UD71
constant: false
boundary condition: false
in compartment: metaid_0000003
initial amount: NaN
initial concentration: 0.0
type: Species
has part: PIRSF000911

428281
stoichiometry: 1.0
species: metaid_0000019
type: SpeciesReference

428342
stoichiometry: 1.0
species: metaid_0000174
type: SpeciesReference

426175
value: 1.7E7
name: kon26
type: LocalParameter

423575
value: 5600000.0
name: kon11
type: LocalParameter

metaid_0000167
reactant: 427834
is version of: GO:0030552
reversible: false
kinetic law: 427870
type: Reaction
is version of: GO:0034237
reactant: 427846
name: cAMP2_R2C2_binding_by_cAMP
product: 427858
fast: false

422072
value: 3.0
name: kcat2
type: LocalParameter

metaid_0000038
fast: false
kinetic law: 422720
reversible: false
type: Reaction
is version of: GO:0033192
reactant: 422684
product: 422708
is version of: http://identifiers.org/ec-code/3.1.3.16
product: 422696
name: D34_Dephospho_by_PP2B

metaid_0000018
is version of: Q9UD71
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: metaid_0000003
name: D137
type: Species

424968
stoichiometry: 1.0
species: metaid_0000080
type: SpeciesReference

425522
stoichiometry: 1.0
species: metaid_0000045
type: SpeciesReference

metaid_0000093
kinetic law: 424944
product: 424932
product: 424920
reactant: 424908
fast: false
reversible: false
name: D34:137_PP2B_unbinding
type: Reaction

metaid_0000113
kinetic law: 425862
product: 425850
product: 425838
reactant: 425826
fast: false
reversible: false
name: D34:75_PP2AP_unbinding
type: Reaction

429221
persistant: true
initial value: true
type: Trigger

427666
stoichiometry: 1.0
species: metaid_0000155
type: SpeciesReference

422204
stoichiometry: 1.0
species: metaid_0000020
type: SpeciesReference

metaid_0000164
initial amount: NaN
boundary condition: false
has part: PIRSF000548
has only substance units: false
constant: false
is version of: GO:0043234
has part: PIRSF000582
initial concentration: 0.0
name: cAMP2_R2C2
type: Species
has part: CHEBI:17489
in compartment: metaid_0000003

metaid_0000035
kinetic law: 422600
product: 422588
product: 422576
reactant: 422564
fast: false
reversible: false
name: D34_CK1_unbinding
type: Reaction

metaid_0000092
fast: false
is version of: GO:0033192
reactant: 424848
type: Reaction
product: 424872
product: 424860
reversible: false
name: D34:137_dephospho_by_PP2B_on_34
is version of: http://identifiers.org/ec-code/3.1.3.16
kinetic law: 424884

424908
stoichiometry: 1.0
species: metaid_0000091
type: SpeciesReference

421844
stoichiometry: 1.0
species: metaid_0000006
type: SpeciesReference

425935
value: 1.7E7
name: kon23
type: LocalParameter

metaid_0000114
kinetic law: 425923
product: 425910
reactant: 425898
reactant: 425886
is version of: GO:0051721
fast: false
reversible: false
name: D75:137_PP2AP_binding
type: Reaction

428317
stoichiometry: 1.0
species: metaid_0000177
type: SpeciesReference

426619
stoichiometry: 1.0
species: metaid_0000066
type: SpeciesReference

424355
value: 3.0
name: kcat14
type: LocalParameter

428956
persistant: true
initial value: true
type: Trigger

metaid_0000015
has part: Q9UD71
initial concentration: 0.0
has part: Q99PS2
has only substance units: false
type: Species
boundary condition: false
constant: false
name: D_CK1
in compartment: metaid_0000003
initial amount: NaN

427918
stoichiometry: 1.0
species: metaid_0000166
type: SpeciesReference

427605
stoichiometry: 1.0
species: metaid_0000128
type: SpeciesReference

metaid_0000165
has part: PIRSF000582
initial amount: NaN
name: cAMP3_R2C2
is version of: GO:0043234
constant: false
has part: PIRSF000548
initial concentration: 0.0
has only substance units: false
has part: CHEBI:17489
in compartment: metaid_0000003
type: Species
boundary condition: false

metaid_0000036
kinetic law: 422660
product: 422648
product: 422636
reactant: 422624
is version of: http://identifiers.org/ec-code/2.7.11.1
fast: false
reversible: false
name: D34_Phospho_by_CK1_on_137
type: Reaction

426968
stoichiometry: 1.0
species: metaid_0000014
type: SpeciesReference

427593
stoichiometry: 1.0
species: metaid_0000155
type: SpeciesReference

427101
stoichiometry: 1.0
species: metaid_0000019
type: SpeciesReference

metaid_0000091
has part: PIRSF000911
constant: false
initial amount: NaN
in compartment: metaid_0000003
initial concentration: 0.0
has only substance units: false
boundary condition: false
has part: Q9UD71
type: Species
name: D34:137_PP2B

metaid_0000115
name: D75:137_PP2AP
in compartment: metaid_0000003
constant: false
has part: Q9UD71
boundary condition: false
type: Species
initial concentration: 0.0
has part: IPR006186
has only substance units: false
initial amount: NaN

423971
stoichiometry: 1.0
species: metaid_0000066
type: SpeciesReference

metaid_0000016
kinetic law: 422060
product: 422048
product: 422036
reactant: 422024
is version of: http://identifiers.org/ec-code/2.7.11.1
fast: false
reversible: false
name: D_Phospho_by_CK1_on_137
type: Reaction

428002
value: 33.0
name: koff37
type: LocalParameter

428402
stoichiometry: 1.0
species: metaid_0000019
type: SpeciesReference

428499
stoichiometry: 1.0
species: metaid_0000180
type: SpeciesReference

427329
stoichiometry: 1.0
species: metaid_0000019
type: SpeciesReference

metaid_0000116
kinetic law: 425983
fast: false
product: 425971
reversible: false
reactant: 425947
name: D75:137_dephospho_by_PP2AP_on_75
product: 425959
type: Reaction
is version of: GO:0004722
is version of: http://identifiers.org/ec-code/3.1.3.16

metaid_0000241
event assignment: 428920
trigger: 428908
use values from trigger time: true
name: ca_on1
type: Event

423467
stoichiometry: 1.0
species: metaid_0000050
type: SpeciesReference

427966
stoichiometry: 1.0
species: metaid_0000160
type: SpeciesReference

423719
stoichiometry: 1.0
species: metaid_0000018
type: SpeciesReference

423251
stoichiometry: 1.0
species: metaid_0000019
type: SpeciesReference

422288
stoichiometry: 1.0
species: metaid_0000025
type: SpeciesReference

428800
stoichiometry: 1.0
species: metaid_0000190
type: SpeciesReference

422912
value: 5600000.0
name: kon8
type: LocalParameter

426151
stoichiometry: 1.0
species: metaid_0000119
type: SpeciesReference

423179
stoichiometry: 1.0
species: metaid_0000034
type: SpeciesReference

metaid_0000117
kinetic law: 426043
product: 426031
product: 426019
reactant: 426007
fast: false
reversible: false
name: D75:137_PP2AP_unbinding
type: Reaction

metaid_0000242
event assignment: 428944
trigger: 428932
use values from trigger time: true
name: ca_on2
type: Event

427714
stoichiometry: 1.0
species: metaid_0000160
type: SpeciesReference

426547
stoichiometry: 1.0
species: metaid_0000126
type: SpeciesReference

425052
stoichiometry: 1.0
species: metaid_0000029
type: SpeciesReference

425826
stoichiometry: 1.0
species: metaid_0000111
type: SpeciesReference

427257
stoichiometry: 1.0
species: metaid_0000019
type: SpeciesReference

428632
stoichiometry: 1.0
species: metaid_0000145
type: SpeciesReference

428560
stoichiometry: 1.0
species: metaid_0000180
type: SpeciesReference

metaid_0000243
event assignment: 428992
trigger: 428980
use values from trigger time: true
name: Ca_on3
type: Event

metaid_0000118
product: 426079
is version of: GO:0004722
fast: false
is version of: http://identifiers.org/ec-code/3.1.3.16
name: D34:75:137_dephospho_by_PP2AP_on 75
reversible: false
reactant: 426067
product: 426091
type: Reaction
kinetic law: 426103

metaid_0000189
kinetic law: 428860
product: 428848
reactant: 428836
fast: false
reversible: false
name: Ca_destroy
type: Reaction

423779
stoichiometry: 1.0
species: metaid_0000053
type: SpeciesReference

424596
value: 10.8
name: koff21
type: LocalParameter

metaid_0000019
is version of: PIRSF000582
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: metaid_0000003
name: PKA
type: Species

422876
stoichiometry: 1.0
species: metaid_0000019
type: SpeciesReference

424247
stoichiometry: 1.0
species: metaid_0000074
type: SpeciesReference

421736
stoichiometry: 1.0
species: metaid_0000005
type: SpeciesReference

425729
stoichiometry: 1.0
species: metaid_0000111
type: SpeciesReference

ORG:
  orgname: EMBL-EBI
n:
  given: Lukas
  family: Endler

metaid_0000188
kinetic law: 428824
product: 428812
reactant: 428800
is version of: GO:0006816
fast: false
reversible: false
name: Ca_in
type: Reaction

metaid_0000119
in compartment: metaid_0000003
name: D34:75:137_PP2AP
boundary condition: false
has only substance units: false
has part: Q9UD71
constant: false
has part: IPR006186
type: Species
initial concentration: 0.0
initial amount: NaN

428788
value: 20.0
name: kcat45
type: LocalParameter

424872
stoichiometry: 1.0
species: metaid_0000029
type: SpeciesReference

metaid_0000244
event assignment: 429017
trigger: 429004
use values from trigger time: true
name: ca_on4
type: Event

metaid_0000059
kinetic law: 423503
product: 423491
product: 423479
reactant: 423467
fast: false
reversible: false
name: D75_PP2AP_unbinding
type: Reaction

425910
stoichiometry: 1.0
species: metaid_0000115
type: SpeciesReference

423106
stoichiometry: 1.0
species: metaid_0000041
type: SpeciesReference

427942
value: 7.5E7
name: kon40
type: LocalParameter

426691
stoichiometry: 1.0
species: metaid_0000066
type: SpeciesReference

426836
value: 3.0E7
name: kon29
type: LocalParameter

metaid_0000245
event assignment: 429041
trigger: 429029
use values from trigger time: true
name: ca_on5
type: Event

metaid_0000187
kinetic law: 428776
product: 428764
product: 428752
reactant: 428740
is version of: GO:0006198
fast: false
reversible: false
name: cAMP_PDEP_degradation
type: Reaction

423094
value: 12.0
name: koff7
type: LocalParameter

425377
value: 3800000.0
name: kon22
type: LocalParameter

425016
value: 75000.0
name: kon27
type: LocalParameter

425341
stoichiometry: 1.0
species: metaid_0000045
type: SpeciesReference

424572
stoichiometry: 1.0
species: metaid_0000019
type: SpeciesReference

422264
stoichiometry: 1.0
species: metaid_0000023
type: SpeciesReference

metaid_0000246
event assignment: 429065
trigger: 429053
use values from trigger time: true
name: ca_on6
type: Event

427533
stoichiometry: 1.0
species: metaid_0000155
type: SpeciesReference

423155
value: 3.0
name: kcat7
type: LocalParameter

metaid_0000186
kinetic law: 428716
product: 428704
product: 428692
reactant: 428680
fast: false
reversible: false
name: cAMP_PDEP_unbinding
type: Reaction

422936
stoichiometry: 1.0
species: metaid_0000045
type: SpeciesReference

426920
stoichiometry: 1.0
species: metaid_0000014
type: SpeciesReference

428075
stoichiometry: 1.0
species: metaid_0000165
type: SpeciesReference

424836
value: 75000.0
name: kon19
type: LocalParameter

426115
value: 24.0
name: kcat26
type: LocalParameter

423755
value: 12.0
name: koff11
type: LocalParameter

424980
stoichiometry: 1.0
species: metaid_0000029
type: SpeciesReference

429293
persistant: true
initial value: true
type: Trigger

427738
stoichiometry: 1.0
species: metaid_0000162
type: SpeciesReference

427233
value: 0.1
name: kcat32
type: LocalParameter

metaid_0000185
initial amount: NaN
boundary condition: false
type: Species
initial concentration: 0.0
name: cAMP_PDEP
has only substance units: false
has part: CHEBI:17489
has part: IPR000396
constant: false
in compartment: metaid_0000003

425076
value: 120.0
name: koff27
type: LocalParameter

428584
stoichiometry: 1.0
species: metaid_0000127
type: SpeciesReference

metaid_0000247
event assignment: 429089
trigger: 429077
use values from trigger time: true
name: ca_on7
type: Event

metaid_0000248
event assignment: 429113
trigger: 429101
use values from trigger time: true
name: ca_on8
type: Event

424776
value: 4.0
name: kcat17
type: LocalParameter

424896
value: 0.03
name: kcat19
type: LocalParameter

metaid_0000099
kinetic law: 425184
product: 425172
reactant: 425160
reactant: 425148
is version of: GO:0051721
fast: false
reversible: false
name: D34:75_PP2A_binding
type: Reaction

425172
stoichiometry: 1.0
species: metaid_0000098
type: SpeciesReference

424067
stoichiometry: 1.0
species: metaid_0000034
type: SpeciesReference

422312
value: 5600000.0
name: kon4
type: LocalParameter

metaid_0000184
reversible: false
is version of: GO:0030552
type: Reaction
fast: false
reactant: 428620
product: 428644
kinetic law: 428656
name: cAMP_PDEP_binding
reactant: 428632
is version of: GO:0004112

425766
stoichiometry: 1.0
species: metaid_0000111
type: SpeciesReference

metaid_0000065
has part: IPR015655
in compartment: metaid_0000003
initial amount: NaN
boundary condition: false
initial concentration: 0.0
has part: Q9UD71
name: D137_PP2C
constant: false
has only substance units: false
type: Species

426331
stoichiometry: 1.0
species: metaid_0000066
type: SpeciesReference

423191
stoichiometry: 1.0
species: metaid_0000019
type: SpeciesReference

426007
stoichiometry: 1.0
species: metaid_0000115
type: SpeciesReference

427437
stoichiometry: 1.0
species: metaid_0000045
type: SpeciesReference

425196
value: 3800000.0
name: kon15
type: LocalParameter

425268
stoichiometry: 1.0
species: metaid_0000098
type: SpeciesReference

metaid_0000066
is: IPR015655
constant: false
boundary condition: false
has only substance units: false
initial concentration: 1.33E-7
initial amount: NaN
in compartment: metaid_0000003
name: PP2C
type: Species

425208
stoichiometry: 1.0
species: metaid_0000098
type: SpeciesReference

426728
stoichiometry: 1.0
species: metaid_0000133
type: SpeciesReference

427389
stoichiometry: 1.0
species: metaid_0000019
type: SpeciesReference

425450
stoichiometry: 1.0
species: metaid_0000103
type: SpeciesReference

427473
stoichiometry: 1.0
species: metaid_0000128
type: SpeciesReference

423731
stoichiometry: 1.0
species: metaid_0000005
type: SpeciesReference

424812
stoichiometry: 1.0
species: metaid_0000091
type: SpeciesReference

426139
stoichiometry: 1.0
species: metaid_0000049
type: SpeciesReference

428728
value: 80.0
name: koff45
type: LocalParameter

426667
stoichiometry: 1.0
species: metaid_0000133
type: SpeciesReference

metaid_0000063
has part: Q9UD71
has part: PIRSF000582
in compartment: metaid_0000003
has only substance units: false
constant: false
type: Species
initial concentration: 0.0
initial amount: NaN
boundary condition: false
name: D137_PKA

424740
stoichiometry: 1.0
species: metaid_0000007
type: SpeciesReference

425413
stoichiometry: 1.0
species: metaid_0000045
type: SpeciesReference

423130
stoichiometry: 1.0
species: metaid_0000053
type: SpeciesReference

429197
persistant: true
initial value: true
type: Trigger

422744
stoichiometry: 1.0
species: metaid_0000030
type: SpeciesReference

422973
value: 3800000.0
name: kon9
type: LocalParameter

422036
stoichiometry: 1.0
species: metaid_0000018
type: SpeciesReference

423335
value: 10.0
name: kcat9
type: LocalParameter

metaid_0000064
kinetic law: 423683
product: 423671
reactant: 423659
reactant: 423647
is version of: GO:0019903
fast: false
reversible: false
name: D137_PP2C_binding
type: Reaction

426752
stoichiometry: 1.0
species: metaid_0000066
type: SpeciesReference

424728
stoichiometry: 1.0
species: metaid_0000087
type: SpeciesReference

423935
value: 2.7
name: kcat12
type: LocalParameter

428764
stoichiometry: 1.0
species: metaid_0000145
type: SpeciesReference

421928
stoichiometry: 1.0
species: metaid_0000015
type: SpeciesReference

423491
stoichiometry: 1.0
species: metaid_0000049
type: SpeciesReference

426391
stoichiometry: 1.0
species: metaid_0000066
type: SpeciesReference

427846
stoichiometry: 1.0
species: metaid_0000161
type: SpeciesReference

427413
value: 4.0
name: kcat33
type: LocalParameter

metaid_0000250
event assignment: 429161
trigger: 429149
use values from trigger time: true
name: ca_on10
type: Event

metaid_0000069
kinetic law: 423863
product: 423851
product: 423839
reactant: 423827
fast: false
reversible: false
name: D137_PKA_unbinding
type: Reaction

426487
stoichiometry: 1.0
species: metaid_0000126
type: SpeciesReference

metaid_0000089
fast: false
reversible: false
product: 424740
kinetic law: 424764
product: 424752
reactant: 424728
is version of: GO:0033192
is version of: http://identifiers.org/ec-code/3.1.3.16
type: Reaction
name: D34:75_dephopsho_by_PP2B_on_34

428195
stoichiometry: 1.0
species: metaid_0000174
type: SpeciesReference

426860
stoichiometry: 1.0
species: metaid_0000137
type: SpeciesReference

424187
stoichiometry: 1.0
species: metaid_0000076
type: SpeciesReference

424692
stoichiometry: 1.0
species: metaid_0000029
type: SpeciesReference

427365
stoichiometry: 1.0
species: metaid_0000149
type: SpeciesReference

425474
stoichiometry: 1.0
species: metaid_0000045
type: SpeciesReference

428704
stoichiometry: 1.0
species: metaid_0000145
type: SpeciesReference

424019
stoichiometry: 1.0
species: metaid_0000018
type: SpeciesReference

423887
stoichiometry: 1.0
species: metaid_0000063
type: SpeciesReference

423431
stoichiometry: 1.0
species: metaid_0000049
type: SpeciesReference

422144
stoichiometry: 1.0
species: metaid_0000020
type: SpeciesReference

422804
stoichiometry: 1.0
species: metaid_0000007
type: SpeciesReference

metaid_0000266
constant: true
value: 2.5E-8
name: kon_low
type: Parameter

425898
stoichiometry: 1.0
species: metaid_0000049
type: SpeciesReference

422768
stoichiometry: 1.0
species: metaid_0000029
type: SpeciesReference

428462
stoichiometry: 1.0
species: metaid_0000180
type: SpeciesReference

422444
stoichiometry: 1.0
species: metaid_0000025
type: SpeciesReference

424415
value: 3.0
name: kcat18
type: LocalParameter

metaid_0000067
kinetic law: 423743
product: 423731
product: 423719
reactant: 423707
fast: false
reversible: false
name: D137_CDK5_unbinding
type: Reaction

metaid_0000252
event assignment: 429185
trigger: 429173
use values from trigger time: true
name: ca_off2
type: Event

423275
value: 10.8
name: koff8
type: LocalParameter

metaid_0000087
initial amount: NaN
constant: false
initial concentration: 0.0
has only substance units: false
type: Species
name: D34:75_PP2B
in compartment: metaid_0000003
has part: PIRSF000911
boundary condition: false
has part: Q9UD71

W3 CDTF: Tue Mar 28 16:55:39 BST 2006

428740
stoichiometry: 1.0
species: metaid_0000185
type: SpeciesReference

428255
stoichiometry: 1.0
species: metaid_0000166
type: SpeciesReference

427305
stoichiometry: 1.0
species: metaid_0000149
type: SpeciesReference

425560
value: 3800000.0
name: kon25
type: LocalParameter

metaid_0000265
constant: true
value: 2.0
name: spike_interval
type: Parameter

metaid_0000068
kinetic law: 423803
is version of: http://identifiers.org/ec-code/2.7.11.22
is version of: GO:0004693
reversible: false
product: 423791
product: 423779
name: D137_Phospho_by_CDK5_on_75
type: Reaction
fast: false
reactant: 423767

metaid_0000251
event assignment: 428968
trigger: 428956
use values from trigger time: true
name: ca_off
type: Event

423311
stoichiometry: 1.0
species: metaid_0000045
type: SpeciesReference

metaid_0000088
kinetic law: 424704
product: 424692
product: 424680
reactant: 424668
fast: false
reversible: false
name: D34:75_PP2B_unbinding
type: Reaction

422516
stoichiometry: 1.0
species: metaid_0000034
type: SpeciesReference

426776
value: 12.0
name: koff28
type: LocalParameter

423959
stoichiometry: 1.0
species: metaid_0000004
type: SpeciesReference

423227
stoichiometry: 1.0
species: metaid_0000043
type: SpeciesReference

428872
value: 1.7
name: k58
type: LocalParameter

metaid_0000085
kinetic law: 424584
product: 424572
product: 424560
reactant: 424548
fast: false
reversible: false
name: D75:137_PKA_unbinding
type: Reaction

425136
value: 0.03
name: kcat27
type: LocalParameter

424127
stoichiometry: 1.0
species: metaid_0000037
type: SpeciesReference

422408
stoichiometry: 1.0
species: metaid_0000030
type: SpeciesReference

422168
stoichiometry: 1.0
species: metaid_0000019
type: SpeciesReference

424331
stoichiometry: 1.0
species: metaid_0000014
type: SpeciesReference

427004
value: 1.0
name: kcat30
type: LocalParameter

426379
stoichiometry: 1.0
species: metaid_0000037
type: SpeciesReference

424295
value: 12.0
name: koff14
type: LocalParameter

metaid_0000139
kinetic law: 426884
product: 426872
product: 426860
reactant: 426848
fast: false
reversible: false
name: CK1P_PP2B_unbinding
type: Reaction

428390
stoichiometry: 1.0
species: metaid_0000177
type: SpeciesReference

metaid_0000159
is version of: GO:0030552
type: Reaction
reactant: 427726
product: 427738
reversible: false
fast: false
is version of: GO:0034237
kinetic law: 427750
reactant: 427714
name: R2C2_cAMP_binding

427774
stoichiometry: 1.0
species: metaid_0000162
type: SpeciesReference

metaid_0000086
kinetic law: 424644
product: 424632
reactant: 424620
reactant: 424608
is version of: GO:0030346
fast: false
reversible: false
name: D34:75_PP2B_binding
type: Reaction

metaid_0000090
kinetic law: 424824
product: 424812
reactant: 424800
reactant: 424788
is version of: GO:0030346
fast: false
reversible: false
name: D34:137_PP2B_binding
type: Reaction

423527
stoichiometry: 1.0
species: metaid_0000018
type: SpeciesReference

422552
value: 3.0
name: kcat4
type: LocalParameter

metaid_0000138
initial concentration: 0.0
initial amount: NaN
name: CK1P_PP2B
has part: PIRSF000911
has only substance units: false
constant: false
has part: Q99PS2
boundary condition: false
type: Species
in compartment: metaid_0000003

426319
stoichiometry: 1.0
species: metaid_0000023
type: SpeciesReference

424632
stoichiometry: 1.0
species: metaid_0000087
type: SpeciesReference

metaid_0000045
is version of: IPR006186
constant: false
boundary condition: false
has only substance units: false
initial concentration: 2.0E-7
initial amount: NaN
in compartment: metaid_0000003
name: PP2A
type: Species

428548
value: 40.0
name: koff44
type: LocalParameter

metaid_0000158
kinetic law: 427690
product: 427678
product: 427666
reactant: 427654
fast: false
reversible: false
name: PP2B_inactivation
type: Reaction

metaid_0000137
is version of: Q99PS2
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: metaid_0000003
name: CK1P
type: Species

428608
value: 10.0
name: kcat44
type: LocalParameter

metaid_0000083
type: Species
initial concentration: 0.0
initial amount: NaN
boundary condition: false
name: D75:137_PKA
constant: false
has part: PIRSF000582
has part: Q9UD71
has only substance units: false
in compartment: metaid_0000003

429245
persistant: true
initial value: true
type: Trigger

426079
stoichiometry: 1.0
species: metaid_0000037
type: SpeciesReference

metaid_0000157
kinetic law: 427630
product: 427617
product: 427605
reactant: 427593
fast: false
reversible: false
name: PP2BinactiveCa2_Ca_unbinding
type: Reaction

428147
stoichiometry: 1.0
species: metaid_0000165
type: SpeciesReference

metaid_0000044
kinetic law: 422961
product: 422949
reactant: 422936
reactant: 422924
is version of: GO:0051721
fast: false
reversible: false
name: D75_PP2A_binding
type: Reaction

428908
persistant: true
initial value: true
type: Trigger

metaid_0000084
kinetic law: 424524
product: 424512
product: 424500
reactant: 424488
is version of: http://identifiers.org/ec-code/2.7.11.11
fast: false
reversible: false
name: D75:137_phospho_by_PKA_on_34
type: Reaction

metaid_0000136
kinetic law: 426824
product: 426812
reactant: 426800
reactant: 426788
is version of: GO:0030346
fast: false
reversible: false
name: CK1P_PP2B_binding
type: Reaction

424391
stoichiometry: 1.0
species: metaid_0000005
type: SpeciesReference

422828
stoichiometry: 1.0
species: metaid_0000041
type: SpeciesReference

425874
value: 40.0
name: koff16
type: LocalParameter

424439
stoichiometry: 1.0
species: metaid_0000019
type: SpeciesReference

425585
stoichiometry: 1.0
species: metaid_0000037
type: SpeciesReference

metaid_0000156
kinetic law: 427569
product: 427557
reactant: 427545
reactant: 427533
is version of: GO:0005509
fast: false
reversible: false
name: PP2B_activation
type: Reaction

422468
stoichiometry: 1.0
species: metaid_0000005
type: SpeciesReference

metaid_0000043
in compartment: metaid_0000003
initial concentration: 0.0
has part: PIRSF000582
name: D75_PKA
boundary condition: false
initial amount: NaN
has part: Q9UD71
constant: false
type: Species
has only substance units: false

428836
stoichiometry: 1.0
species: metaid_0000154
type: SpeciesReference

metaid_0000081
type: Reaction
product: 424391
is version of: GO:0004693
fast: false
kinetic law: 424403
product: 424379
reversible: false
reactant: 424367
is version of: http://identifiers.org/ec-code/2.7.11.22
name: D34:137_phospho_by_CDK5_on_75

metaid_0000022
kinetic law: 422180
product: 422168
product: 422156
reactant: 422144
fast: false
reversible: false
name: D_PKA_unbinding
type: Reaction

428523
stoichiometry: 1.0
species: metaid_0000127
type: SpeciesReference

427497
stoichiometry: 1.0
species: metaid_0000155
type: SpeciesReference

metaid_0000135
kinetic law: 426764
product: 426752
product: 426740
reactant: 426728
fast: false
reversible: false
name: D34:75:137_PP2C_unbinding
type: Reaction

422672
value: 3.0
name: kcat5
type: LocalParameter

metaid_0000042
kinetic law: 422900
product: 422888
reactant: 422876
reactant: 422864
is version of: GO:0034236
fast: false
reversible: false
name: D75_PKA_binding
type: Reaction

metaid_0000061
boundary condition: false
has only substance units: false
constant: false
initial concentration: 0.0
initial amount: NaN
has part: Q9UD71
in compartment: metaid_0000003
type: Species
name: D137_CDK5
has part: Q03114

423299
stoichiometry: 1.0
species: metaid_0000004
type: SpeciesReference

422576
stoichiometry: 1.0
species: metaid_0000023
type: SpeciesReference

428330
stoichiometry: 1.0
species: metaid_0000019
type: SpeciesReference

metaid_0000021
kinetic law: 422120
product: 422108
reactant: 422096
reactant: 422084
is version of: GO:0034236
fast: false
reversible: false
name: D_PKA_binding
type: Reaction

metaid_0000134
product: 426691
is version of: http://identifiers.org/ec-code/3.1.3.16
reversible: false
reactant: 426667
name: D34:75:137_dephospho_by_PP2C_on_137
kinetic law: 426703
fast: false
product: 426679
is version of: GO:0004722
type: Reaction

metaid_0000082
kinetic law: 424464
product: 424452
reactant: 424439
reactant: 424427
is version of: GO:0034236
fast: false
reversible: false
name: D75:137_PKA_binding
type: Reaction

421976
stoichiometry: 1.0
species: metaid_0000004
type: SpeciesReference

428207
stoichiometry: 1.0
species: metaid_0000019
type: SpeciesReference

423419
stoichiometry: 1.0
species: metaid_0000004
type: SpeciesReference

metaid_0000062
kinetic law: 423623
product: 423611
reactant: 423599
reactant: 423587
is version of: GO:0034236
fast: false
reversible: false
name: D137_PKA_binding
type: Reaction

422108
stoichiometry: 1.0
species: metaid_0000020
type: SpeciesReference

426355
value: 3.0
name: kcat20
type: LocalParameter

425790
stoichiometry: 1.0
species: metaid_0000049
type: SpeciesReference

metaid_0000041
has part: Q9UD71
constant: false
has part: Q99PS2
has only substance units: false
boundary condition: false
type: Species
name: D75_CK1
in compartment: metaid_0000003
initial concentration: 0.0
initial amount: NaN

424548
stoichiometry: 1.0
species: metaid_0000083
type: SpeciesReference

424488
stoichiometry: 1.0
species: metaid_0000083
type: SpeciesReference

424920
stoichiometry: 1.0
species: metaid_0000037
type: SpeciesReference

427822
value: 5.4E7
name: kon38
type: LocalParameter

428123
value: 110.0
name: koff39
type: LocalParameter

427798
stoichiometry: 1.0
species: metaid_0000164
type: SpeciesReference

metaid_0000133
has part: IPR015655
type: Species
constant: false
has part: Q9UD71
initial amount: NaN
name: D34:75:137_PP2C
in compartment: metaid_0000003
has only substance units: false
initial concentration: 0.0
boundary condition: false

metaid_0000020
has part: PIRSF000582
initial amount: NaN
initial concentration: 0.0
type: Species
has only substance units: false
in compartment: metaid_0000003
has part: Q9UD71
constant: false
boundary condition: false
name: D_PKA

423359
stoichiometry: 1.0
species: metaid_0000007
type: SpeciesReference

422012
value: 12.0
name: koff2
type: LocalParameter

423827
stoichiometry: 1.0
species: metaid_0000063
type: SpeciesReference

421904
stoichiometry: 1.0
species: metaid_0000004
type: SpeciesReference

429269
persistant: true
initial value: true
type: Trigger

metaid_0000040
kinetic law: 422840
product: 422828
reactant: 422816
reactant: 422804
is version of: GO:0019901
fast: false
reversible: false
name: D75_CK1_binding
type: Reaction

427197
stoichiometry: 1.0
species: metaid_0000145
type: SpeciesReference

425112
stoichiometry: 1.0
species: metaid_0000029
type: SpeciesReference

425850
stoichiometry: 1.0
species: metaid_0000049
type: SpeciesReference

metaid_0000132
kinetic law: 426643
product: 426631
reactant: 426619
reactant: 426607
is version of: GO:0019903
fast: false
reversible: false
name: D34:75:137_PP2C_binding
type: Reaction

metaid_0000080
is version of: Q9UD71
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: metaid_0000003
name: D34:75:137
type: Species

metaid_0000060
kinetic law: 423563
product: 423551
reactant: 423539
reactant: 423527
is version of: GO:0019901
fast: false
reversible: false
name: D137_CDK5_binding
type: Reaction

425664
stoichiometry: 1.0
species: metaid_0000045
type: SpeciesReference

423695
value: 7500000.0
name: kon13
type: LocalParameter

421772
value: 5600000.0
name: kon1
type: LocalParameter

orgname: EMBL-EBI

n:
  given: Nicolas
  family: Le Novère

W3 CDTF: Thu Jul 05 17:51:03 BST 2012