metaid_0000083
kinetic law: 806511
name: PI 3,4,5 P3 generation
reversible: true
is version of: GO:0016314
product: 806499
is: http://identifiers.org/ec-code/2.7.1.153
fast: false
is: R04545
reactant: 806487
is: http://identifiers.org/ec-code/3.1.3.67
type: Reaction

806451
stoichiometry: 1.0
species: metaid_0000053
type: SpeciesReference

metaid_0000053
is version of: P35568
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: metaid_0000042
name: Phosphorylated IRS1
type: Species

metaid_0000063
initial concentration: 0.29
type: Species
constant: false
has only substance units: false
boundary condition: false
name: PI3,4P2
initial amount: NaN
is: CHEBI:16152
in compartment: metaid_0000042
is: C11554

metaid_0000043
is: P01308
constant: false
boundary condition: false
has only substance units: false
initial concentration: 1.0E8
initial amount: NaN
in compartment: metaid_0000097
name: Insulin
type: Species

metaid_0000025
constant: true
value: 2.77
type: Parameter

metaid_0000012
constant: true
value: 2.1E-4
type: Parameter

metaid_0000039
constant: true
value: 1.0
type: Parameter

metaid_0000093
event assignment: 806751
trigger: 806739
notes: This is the condition to assign values to k5 as given in the appendix
use values from trigger time: true
type: Event

806439
stoichiometry: 1.0
species: metaid_0000059
type: SpeciesReference

metaid_0000032
constant: false
value: 0.0
type: Parameter

metaid_0000019
constant: true
value: 10.0
type: Parameter

806487
stoichiometry: 1.0
species: metaid_0000054
type: SpeciesReference

metaid_0000072
kinetic law: 806103
modifier: 806091
product: 806079
reactant: 806067
is version of: GO:0043559
fast: false
reversible: true
name: Insulin Binding
type: Reaction

metaid_0000005
constant: true
value: 6.0E-8
type: Parameter

metaid_0000062
is version of: P41743
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: metaid_0000042
name: Activated PKC
type: Species

806523
stoichiometry: 1.0
species: metaid_0000063
type: SpeciesReference

805959
exponent: 1.0
scale: -15
multipler: 1.0
kind: MOLE
type: SBMLUnit

806079
stoichiometry: 1.0
species: metaid_0000047
type: SpeciesReference

metaid_0000082
fast: false
name: IRS1-PI3K complex formation
is version of: GO:0005515
product: 806463
is version of: GO:0043548
kinetic law: 806475
type: Reaction
reactant: 806451
reversible: true
reactant: 806439

metaid_0000054
has only substance units: false
is: CHEBI:18348
initial concentration: 99.4
initial amount: NaN
is: C04637
in compartment: metaid_0000042
constant: false
type: Species
name: PI4,5P2
boundary condition: false

metaid_0000064
is version of: P14672
constant: false
boundary condition: false
has only substance units: false
initial concentration: 4.0
initial amount: NaN
in compartment: metaid_0000097
name: Cell surface GLUT4
type: Species

806655
stoichiometry: 1.0
species: metaid_0000058
type: SpeciesReference

806235
stoichiometry: 1.0
species: metaid_0000050
type: SpeciesReference

805983
stoichiometry: 1.0
species: metaid_0000044
type: SpeciesReference

metaid_0000011
constant: true
value: 0.0021
type: Parameter

metaid_0000074
kinetic law: 806175
product: 806163
reactant: 806151
is version of: GO:0031623
fast: false
reversible: true
name: Receptor endocytosis
type: Reaction

metaid_0000092
event assignment: 806727
trigger: 806715
notes: When time is greater than or equal to 15 minutes Insulin input is set to zero
use values from trigger time: true
type: Event

metaid_0000026
constant: false
value: 0.0
type: Parameter

metaid_0000044
is version of: P06213
constant: false
boundary condition: false
has only substance units: false
initial concentration: 900.0
initial amount: NaN
in compartment: metaid_0000097
name: Unbound Insulin Receptor
type: Species

metaid_0000031
constant: true
value: 0.167
type: Parameter

metaid_0000073
kinetic law: 806139
product: 806127
reactant: 806115
is version of: GO:0006470
fast: false
reversible: false
name: Receptor dephosphorylation
type: Reaction

metaid_0000006
constant: true
value: 20.0
type: Parameter

806307
stoichiometry: 1.0
species: metaid_0000049
type: SpeciesReference

806355
stoichiometry: 1.0
species: metaid_0000048
type: SpeciesReference

806535
stoichiometry: 1.0
species: metaid_0000055
type: SpeciesReference

metaid_0000037
constant: true
value: 1.0
type: Parameter

806283
stoichiometry: 1.0
species: metaid_0000048
type: SpeciesReference

metaid_0000055
boundary condition: false
initial amount: NaN
in compartment: metaid_0000042
constant: false
type: Species
is: C05981
initial concentration: 0.31
is: CHEBI:16618
name: PI3,4,5P3
has only substance units: false

metaid_0000081
kinetic law: 806427
type: Reaction
reversible: true
is: GO:0004716
fast: true
modifier: 806403
is: http://identifiers.org/ec-code/2.7.10.1
name: IRS1 activation
product: 806391
modifier: 806415
reactant: 806379

metaid_0000027
constant: true
value: 6.9315
type: Parameter

metaid_0000095
constant: false
value: 0.0
type: Parameter

metaid_0000041
constant: true
value: 5.0
type: Parameter

metaid_0000075
kinetic law: 806211
product: 806199
reactant: 806187
is version of: GO:0031623
fast: false
reversible: true
name: Receptor transport
type: Reaction

806715
persistant: true
initial value: true
type: Trigger

metaid_0000010
constant: true
value: 0.003
type: Parameter

806199
stoichiometry: 1.0
species: metaid_0000049
type: SpeciesReference

metaid_0000017
constant: true
value: 1.396
type: Parameter

metaid_0000040
constant: true
value: 9.09091
type: Parameter

metaid_0000030
constant: true
value: 0.00696
type: Parameter

metaid_0000020
constant: false
value: 0.0
type: Parameter

metaid_0000007
constant: true
value: 2500.0
type: Parameter

metaid_0000060
is version of: Q9Y243
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: metaid_0000042
name: Activated Akt
type: Species

806679
stoichiometry: 1.0
species: metaid_0000058
type: SpeciesReference

806691
stoichiometry: 1.0
species: metaid_0000064
type: SpeciesReference

806499
stoichiometry: 1.0
species: metaid_0000055
type: SpeciesReference

metaid_0000056
is version of: Q9Y243
constant: false
boundary condition: false
has only substance units: false
initial concentration: 100.0
initial amount: NaN
in compartment: metaid_0000042
name: Unactivated Akt
type: Species

806223
stoichiometry: 1.0
species: metaid_0000046
type: SpeciesReference

805971
exponent: 1.0
scale: 0
multipler: 60.0
kind: SECOND
type: SBMLUnit

metaid_0000080
kinetic law: 806367
product: 806355
reactant: 806343
fast: false
reversible: false
name: Intracellular receptor dephosphorylation
type: Reaction

metaid_0000028
constant: false
value: 0.0
type: Parameter

806067
stoichiometry: 1.0
species: metaid_0000046
type: SpeciesReference

metaid_0000042
is: GO:0005622
constant: true
size: 1.0
spatial dimensions: 3.0
type: Compartment

metaid_0000038
constant: true
value: 1.0
type: Parameter

metaid_0000094
event assignment: 806775
trigger: 806763
use values from trigger time: true
type: Event

metaid_0000076
kinetic law: 806247
product: 806235
reactant: 806223
is version of: GO:0031623
fast: false
reversible: true
name: Receptor transport
type: Reaction

metaid_0000089
kinetic law: 806703
product: 806691
reactant: 806679
is version of: GO:0006886
fast: false
reversible: true
name: GLUT4 translocation
type: Reaction

806571
stoichiometry: 1.0
species: metaid_0000060
type: SpeciesReference

metaid_0000018
constant: true
value: 7.06E-4
type: Parameter

metaid_0000049
is version of: P06213
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: metaid_0000042
name: Phosphorylated twice bound intracellular receptor
type: Species

metaid_0000061
in compartment: metaid_0000042
name: IRS1- PI3 Kinase Complex
type: Species
boundary condition: false
has only substance units: false
initial amount: NaN
constant: false
has part: Q8WYR1
has part: P35568
initial concentration: 0.0

metaid_0000008
constant: true
value: 0.2
type: Parameter

metaid_0000047
is version of: P06213
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: metaid_0000097
name: Phosphorylated twice bound receptor
type: Species

metaid_0000009
constant: true
value: 3.3333334E-4
type: Parameter

metaid_0000029
constant: true
value: 6.9315
type: Parameter

806187
stoichiometry: 1.0
species: metaid_0000047
type: SpeciesReference

metaid_0000057
is version of: P41743
constant: false
boundary condition: false
has only substance units: false
initial concentration: 100.0
initial amount: NaN
in compartment: metaid_0000042
name: Unactivated PKC
type: Species

806127
stoichiometry: 1.0
species: metaid_0000044
type: SpeciesReference

metaid_0000015
constant: true
value: 0.461
type: Parameter

metaid_0000077
kinetic law: 806271
product: 806259
is version of: GO:0032800
fast: false
reversible: false
name: Receptor synthesis
type: Reaction

metaid_0000022
constant: true
value: 0.13145
type: Parameter

metaid_0000088
kinetic law: 806667
reactant: 806655
is version of: GO:0044257
fast: false
reversible: false
name: GLUT4 degradation
type: Reaction

metaid_0000098
unit: 805959
name: femtomole
type: SBMLUnitsDef

metaid_0000036
constant: true
value: 897.0
type: Parameter

metaid_0000048
is version of: P06213
constant: false
boundary condition: false
has only substance units: false
initial concentration: 100.0
initial amount: NaN
in compartment: metaid_0000042
name: Unbound unphosphorylated intracellular receptor
type: Species

806379
stoichiometry: 1.0
species: metaid_0000052
type: SpeciesReference

metaid_0000058
is version of: P14672
constant: false
boundary condition: false
has only substance units: false
initial concentration: 96.0
initial amount: NaN
in compartment: metaid_0000042
name: Intracellular GLUT4
type: Species

806559
stoichiometry: 1.0
species: metaid_0000056
type: SpeciesReference

806607
stoichiometry: 1.0
species: metaid_0000062
type: SpeciesReference

806151
stoichiometry: 1.0
species: metaid_0000044
type: SpeciesReference

metaid_0000078
kinetic law: 806295
reactant: 806283
is version of: GO:0032801
fast: false
reversible: false
name: Receptor degradation
type: Reaction

806631
stoichiometry: 1.0
species: metaid_0000058
type: SpeciesReference

metaid_0000087
kinetic law: 806643
product: 806631
is version of: GO:0006417
fast: false
reversible: false
name: GLUT4 synthesis
type: Reaction

metaid_0000021
constant: true
value: 1.39
type: Parameter

metaid_0000097
is: GO:0009986
constant: true
size: 1.0
spatial dimensions: 3.0
type: Compartment

806259
stoichiometry: 1.0
species: metaid_0000048
type: SpeciesReference

metaid_0000035
constant: false
value: 0.0
type: Parameter

metaid_0000016
constant: true
value: 4.16
type: Parameter

metaid_0000050
is version of: P06213
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: metaid_0000042
name: Phosphorylated once bound intracellular receptor
type: Species

806031
stoichiometry: 1.0
species: metaid_0000045
type: SpeciesReference

metaid_0000045
is version of: P06213
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: metaid_0000097
name: Unphosphorylated once bound receptor
type: Species

metaid_0000059
is version of: Q8WYR1
constant: false
boundary condition: false
has only substance units: false
initial concentration: 100.0
initial amount: NaN
in compartment: metaid_0000042
name: PI3 Kinase
type: Species

806319
stoichiometry: 1.0
species: metaid_0000048
type: SpeciesReference

806391
stoichiometry: 1.0
species: metaid_0000053
type: SpeciesReference

805995
stoichiometry: 1.0
species: metaid_0000045
type: SpeciesReference

metaid_0000079
kinetic law: 806331
product: 806319
reactant: 806307
fast: false
reversible: false
name: Intracellular receptor dephosphorylation
type: Reaction

metaid_0000086
kinetic law: 806619
product: 806607
reactant: 806595
is: GO:0007205
fast: false
reversible: true
name: PKC activation
type: Reaction

metaid_0000013
constant: false
value: 0.0
type: Parameter

metaid_0000024
constant: true
value: 2.961
type: Parameter

806463
stoichiometry: 1.0
species: metaid_0000061
type: SpeciesReference

metaid_0000003
constant: true
value: 6.0E-8
type: Parameter

806115
stoichiometry: 1.0
species: metaid_0000046
type: SpeciesReference

metaid_0000070
kinetic law: 806019
modifier: 806007
product: 805995
reactant: 805983
is version of: GO:0043559
fast: false
reversible: true
name: Insulin binding
type: Reaction

metaid_0000034
constant: true
value: 0.001155
type: Parameter

806763
persistant: true
initial value: true
type: Trigger

806739
persistant: true
initial value: true
type: Trigger

W3 CDTF: Wed Jun 05 11:40:57 BST 2013

806595
stoichiometry: 1.0
species: metaid_0000057
type: SpeciesReference

BIOMD0000000137
parameter: metaid_0000016
parameter: metaid_0000007
species: metaid_0000050
curated: true
parameter: metaid_0000022
reaction: metaid_0000076
parameter: metaid_0000013
parameter: metaid_0000028
parameter: metaid_0000019
substance units: metaid_0000098
parameter: metaid_0000034
reaction: metaid_0000088
species: metaid_0000063
parameter: metaid_0000025
compartment: metaid_0000042
reaction: metaid_0000077
species: metaid_0000048
rule: metaid_0000068
reaction: metaid_0000085
area units: metaid_0000005
parameter: metaid_0000037
volume units: metaid_0000084
reaction: metaid_0000089
species: metaid_0000055
species: metaid_0000056
event: metaid_0000092
species: metaid_0000043
is described by: http://identifiers.org/pubmed/12376338
parameter: metaid_0000020
reaction: metaid_0000081
species: metaid_0000060
parameter: metaid_0000011
name: Sedaghat2002_InsulinSignalling_noFeedback
species: metaid_0000061
reaction: metaid_0000072
parameter: metaid_0000032
units def: metaid_0000099
type: SBMLModel
parameter: metaid_0000023
reaction: metaid_0000084
parameter: metaid_0000035
is part of: hsa04910
parameter: metaid_0000008
species: metaid_0000059
occurs in: http://identifiers.org/taxonomy/9606
parameter: metaid_0000014
parameter: metaid_0000095
parameter: metaid_0000005
rule: metaid_0000066
species: metaid_0000047
reaction: metaid_0000074
parameter: metaid_0000026
reaction: metaid_0000078
parameter: metaid_0000017
reaction: metaid_0000070
rule: metaid_0000067
reaction: metaid_0000086
parameter: metaid_0000038
is: MODEL6526728774
parameter: metaid_0000029
reaction: metaid_0000082
event: metaid_0000093
species: metaid_0000046
species: metaid_0000053
compartment: metaid_0000097
species: metaid_0000054
species: metaid_0000049
parameter: metaid_0000012
parameter: metaid_0000041
parameter: metaid_0000003
reaction: metaid_0000073
parameter: metaid_0000024
parameter: metaid_0000015
rule: metaid_0000096
parameter: metaid_0000030
parameter: metaid_0000021
parameter: metaid_0000036
reaction: metaid_0000075
parameter: metaid_0000027
reaction: metaid_0000079

metaid_0000046
is version of: P06213
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: metaid_0000097
name: Phosphorylated once bound receptor
type: Species

metaid_0000084
kinetic law: 806547
product: 806535
reactant: 806523
is version of: GO:0006661
fast: false
reversible: true
name: PI 3,4,5P3 generation
type: Reaction

metaid_0000085
kinetic law: 806583
product: 806571
reactant: 806559
is version of: GO:0006468
fast: false
reversible: true
name: Akt activation
type: Reaction

metaid_0000023
constant: true
value: 42.15
type: Parameter

metaid_0000014
constant: true
value: 1.67E-18
type: Parameter

806163
stoichiometry: 1.0
species: metaid_0000048
type: SpeciesReference

metaid_0000071
kinetic law: 806055
product: 806043
reactant: 806031
is version of: GO:0046777
fast: false
reversible: false
name: Receptor Autophosphorylation
type: Reaction

metaid_0000004
constant: true
value: 0.2
type: Parameter

806043
stoichiometry: 1.0
species: metaid_0000046
type: SpeciesReference

806343
stoichiometry: 1.0
species: metaid_0000050
type: SpeciesReference

metaid_0000033
constant: true
value: 0.11088
type: Parameter

metaid_0000099
unit: 805971
name: minute
type: SBMLUnitsDef

metaid_0000052
is version of: P35568
constant: false
boundary condition: false
has only substance units: false
initial concentration: 1000.0
initial amount: NaN
in compartment: metaid_0000042
name: Unphosphorylated IRS1
type: Species

given: Harish
family: Dharuri

W3 CDTF: Mon Aug 06 16:09:19 BST 2007

orgname: California Institute of Technology