Set cAMPlow=0.2 for nM ET, and cAMPlow=0.5 for pM ET
At time 1 minute a nanomolar concentration of endothelin is added.
The model is according to the paper Endothelin Action on Pituitary Lactotrophs: One Receptor, Many GTP-Binding Proteins Figure 1 has been simulated by MathSBML. The figure for the [Ca2+]i and [Ca2+]ER have been normalized in the paper.Original model comes from http://www.math.fsu.edu/~bertram/software/pituitary The units for parameters and species are varied from one to another, so I omit the unit definition here . Conductances in pS; currents in fA; Ca concentrations in uM; time in ms To the extent possible under law, all copyright and related or neighbouring rights to this encoded model have been dedicated to the public domain worldwide. Please refer to CC0 Public Domain Dedication for more information. In summary, you are entitled to use this encoded model in absolutely any manner you deem suitable, verbatim, or with modification, alone or embedded it in a larger context, redistribute it, commercially or not, in a restricted way or not. To cite BioModels Database, please use: Li C, Donizelli M, Rodriguez N, Dharuri H, Endler L, Chelliah V, Li L, He E, Henry A, Stefan MI, Snoep JL, Hucka M, Le Novère N, Laibe C (2010) BioModels Database: An enhanced, curated and annotated resource for published quantitative kinetic models. BMC Syst Biol., 4:92.
variable for direct inhibition of secretion