119328
stoichiometry: 1.0
species: metaid_0000006
type: SpeciesReference

119460
persistant: true
initial value: true
type: Trigger

metaid_0000026
constant: false
value: NaN
type: Parameter

metaid_0000009
constant: true
value: 8.314
name: gas constant
type: Parameter

metaid_0000012
constant: true
value: 5.4
name: extracellular K
type: Parameter

metaid_0000045
kinetic law: 119448
product: 119436
reactant: 119424
is version of: GO:0015459
is version of: GO:0043266
fast: false
reversible: true
name: c1-i transition
type: Reaction

metaid_0000005
name: ClosedState_2
initial concentration: 0.0
is version of: GO:0008076
type: Species
boundary condition: false
initial amount: NaN
in compartment: metaid_0000003
is version of: IPR003967
has only substance units: false
constant: false

119279
stoichiometry: 1.0
species: metaid_0000004
type: SpeciesReference

metaid_0000025
constant: false
value: NaN
type: Parameter

119484
persistant: true
initial value: true
type: Trigger

metaid_0000051
event assignment: 119496
trigger: 119484
notes: when t > 300, v=vhold.
use values from trigger time: true
type: Event

metaid_0000021
constant: false
value: NaN
type: Parameter

metaid_0000041
kinetic law: 119304
product: 119292
reactant: 119279
is version of: GO:0043266
is version of: GO:0015459
fast: false
reversible: true
name: c3-c2 transition
type: Reaction

metaid_0000027
constant: false
value: NaN
type: Parameter

metaid_0000008
name: InactivationState
constant: false
is version of: GO:0008076
in compartment: metaid_0000003
initial amount: NaN
initial concentration: 0.0
boundary condition: false
type: Species
has only substance units: false
is version of: IPR003967

metaid_0000048
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.1
initial amount: NaN
in compartment: metaid_0000003
name: cardiac delayed rectifier current
type: Species

metaid_0000013
constant: true
value: 140.0
name: introcellular K
type: Parameter

metaid_0000044
kinetic law: 119412
product: 119400
reactant: 119388
is version of: GO:0043266
is version of: GO:0015459
fast: false
reversible: true
name: o-i transition
type: Reaction

BIOMD0000000121
parameter: metaid_0000020
parameter: metaid_0000019
length unit: length
compartment: metaid_0000003
units def: metaid_0000049
species: metaid_0000007
parameter: metaid_0000025
parameter: metaid_0000015
volume units: metaid_0000084
is: MODEL2898180293
rule: metaid_0000038
reaction: metaid_0000042
parameter: metaid_0000014
species: metaid_0000004
occurs in: http://identifiers.org/taxonomy/10141
event: metaid_0000051
substance units: metaid_0000050
rule: metaid_0000053
rule: metaid_0000034
area units: metaid_0000005
rule: metaid_0000030
curated: true
rule: metaid_0000037
parameter: metaid_0000033
reaction: metaid_0000045
parameter: metaid_0000024
parameter: metaid_0000013
parameter: metaid_0000028
species: metaid_0000005
rule: metaid_0000039
parameter: metaid_0000023
parameter: metaid_0000012
parameter: metaid_0000027
notes: This model is according to the paper Cellular consequences of HEGR mutations in the long QT syndrome: precursors to sudden cardiac death. The author used Markovian model of cardiac Ikr in the paper. Figure4B in the paper has been reproduced using CellDesigner3.5.1. The cell is depolarized to the indicated test potential for 250ms (from 50ms to 300ms) from a holding potential of -40mV and then repolarized to -40mV. Change the value for vtest from -30,-20,-10,0,10,20,30,40 for each simulation in order to produce the different cureve in the paper. To the extent possible under law, all copyright and related or neighbouring rights to this encoded model have been dedicated to the public domain worldwide. Please refer to CC0 Public Domain Dedication for more information. In summary, you are entitled to use this encoded model in absolutely any manner you deem suitable, verbatim, or with modification, alone or embedded it in a larger context, redistribute it, commercially or not, in a restricted way or not. To cite BioModels Database, please use: Li C, Donizelli M, Rodriguez N, Dharuri H, Endler L, Chelliah V, Li L, He E, Henry A, Stefan MI, Snoep JL, Hucka M, Le Novère N, Laibe C (2010) BioModels Database: An enhanced, curated and annotated resource for published quantitative kinetic models. BMC Syst Biol., 4:92.
time units: metaid_0000047
is homolog to: http://identifiers.org/omim/152427
parameter: metaid_0000018
is version of: GO:0005251
rule: metaid_0000035
species: metaid_0000008
name: Clancy2001_Kchannel
rule: metaid_0000031
units def: metaid_0000047
parameter: metaid_0000021
parameter: metaid_0000009
units def: metaid_0000050
reaction: metaid_0000044
species: metaid_0000006
reaction: metaid_0000043
modified:
  W3 CDTF: Thu Jul 05 17:45:33 BST 2012
type: SBMLModel
parameter: metaid_0000022
parameter: metaid_0000011
parameter: metaid_0000026
is described by: http://identifiers.org/pubmed/11334834
parameter: metaid_0000010
creator:
  ORG:
    orgname: BNMC
  n:
    given: Enuo
    family: He
created:
  W3 CDTF: Wed Jun 20 10:51:21 BST 2007
species: metaid_0000048
rule: metaid_0000036
event: metaid_0000046
reaction: metaid_0000041
rule: metaid_0000032
is version of: GO:0043266

metaid_0000024
constant: false
value: NaN
type: Parameter

119243
exponent: 1.0
scale: -3
multipler: 1.0
kind: SECOND
type: SBMLUnit

metaid_0000004
name: ClosedState_3
has only substance units: false
boundary condition: false
constant: false
in compartment: metaid_0000003
is version of: IPR003967
type: Species
initial amount: NaN
initial concentration: 1.0
is version of: GO:0008076

metaid_0000020
constant: false
value: NaN
type: Parameter

metaid_0000050
unit: 119267
name: mM
type: SBMLUnitsDef

119364
stoichiometry: 1.0
species: metaid_0000007
type: SpeciesReference

119436
stoichiometry: 1.0
species: metaid_0000008
type: SpeciesReference

metaid_0000028
constant: false
value: NaN
type: Parameter

metaid_0000010
constant: true
value: 96.485
name: Faraday constant
type: Parameter

metaid_0000043
kinetic law: 119376
product: 119364
reactant: 119352
is version of: GO:0043266
is version of: GO:0015459
fast: false
reversible: true
name: c1-o transition
type: Reaction

metaid_0000018
constant: false
value: NaN
name: reversal potential for k
type: Parameter

metaid_0000047
unit: 119243
name: ms
type: SBMLUnitsDef

119400
stoichiometry: 1.0
species: metaid_0000008
type: SpeciesReference

119316
stoichiometry: 1.0
species: metaid_0000005
type: SpeciesReference

119292
stoichiometry: 1.0
species: metaid_0000005
type: SpeciesReference

metaid_0000014
constant: true
value: -40.0
name: holding_potential
type: Parameter

metaid_0000033
notes: when (t gt 0) and ( t lt 50), v=vhold=-40
constant: false
value: -40.0
name: membrane_potential
type: Parameter

metaid_0000003
is version of: GO:0005623
constant: true
size: 1.0
spatial dimensions: 3.0
type: Compartment

metaid_0000023
constant: true
value: 1.077
type: Parameter

119267
exponent: 1.0
scale: -3
multipler: 1.0
kind: MOLE
type: SBMLUnit

metaid_0000007
is version of: IPR003967
type: Species
is version of: GO:0008076
initial amount: NaN
initial concentration: 0.06
boundary condition: false
in compartment: metaid_0000003
constant: false
has only substance units: false
name: OpenState

metaid_0000042
kinetic law: 119340
product: 119328
reactant: 119316
is version of: GO:0043266
is version of: GO:0015459
fast: false
reversible: true
name: c2-c1 transition
type: Reaction

metaid_0000046
event assignment: 119472
trigger: 119460
notes: when ( t gt 50 ) and ( t lt 300 ), v=vtest
is version of: GO:0050981
use values from trigger time: true
type: Event

metaid_0000011
constant: true
value: 310.0
name: temperature
type: Parameter

metaid_0000015
constant: true
value: 0.0
name: test_potential
type: Parameter

119424
stoichiometry: 1.0
species: metaid_0000006
type: SpeciesReference

metaid_0000022
constant: true
value: 2.172
type: Parameter

119255
exponent: 1.0
scale: -3
multipler: 1.0
kind: VOLT
type: SBMLUnit

metaid_0000019
constant: false
value: NaN
name: membrane_conductance
type: Parameter

metaid_0000006
constant: false
initial concentration: 0.0
has only substance units: false
type: Species
boundary condition: false
in compartment: metaid_0000003
initial amount: NaN
is version of: IPR003967
name: ClosedState_1
is version of: GO:0008076

119352
stoichiometry: 1.0
species: metaid_0000006
type: SpeciesReference

119388
stoichiometry: 1.0
species: metaid_0000007
type: SpeciesReference