metaid_0000010
constant: true
value: 2.0
type: Parameter

metaid_0000024
constant: true
value: 0.1
type: Parameter

818409
stoichiometry: 1.0
species: metaid_0000042
type: SpeciesReference

metaid_0000043
type: Species
in compartment: metaid_0000037
has part: IPR015454
initial concentration: 0.0
name: Thr161-Tyr15 phosphorylated dimer
constant: false
initial amount: NaN
boundary condition: false
has only substance units: false
has part: P35567

metaid_0000006
constant: true
value: 1.0
type: Parameter

metaid_0000076
kinetic law: 818769
modifier: 818757
product: 818745
is: http://identifiers.org/ec-code/2.7.11.22
is version of: GO:0004674
fast: false
reversible: false
name: cdc25 activation
type: Reaction

metaid_0000077
kinetic law: 818793
reactant: 818781
is version of: GO:0044257
fast: false
reversible: false
name: cdc25 deactivation
type: Reaction

metaid_0000044
is version of: P30311
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: metaid_0000037
name: phosphorylated cdc25
type: Species

818962
stoichiometry: 1.0
species: metaid_0000047
type: SpeciesReference

818313
stoichiometry: 1.0
species: metaid_0000039
type: SpeciesReference

metaid_0000086
unit: 818252
name: minutes
type: SBMLUnitsDef

metaid_0000011
constant: false
value: 0.0
type: Parameter

metaid_0000067
kinetic law: 818481
reactant: 818469
is version of: GO:0008054
fast: false
reversible: false
name: cyclin degradation
type: Reaction

818673
stoichiometry: 1.0
species: metaid_0000041
type: SpeciesReference

metaid_0000065
is version of: GO:0045736
product: 818409
name: Tyr15 phosphorylation
reactant: 818397
type: Reaction
reversible: false
kinetic law: 818421
is version of: REACT 6178
fast: false
is: http://identifiers.org/ec-code/2.7.10.2

metaid_0000039
is: IPR015454
constant: false
boundary condition: false
has only substance units: false
initial concentration: 100.0
initial amount: NaN
in compartment: metaid_0000037
name: cyclin
type: Species

818240
exponent: 1.0
scale: -9
multipler: 1.0
kind: MOLE
type: SBMLUnit

818589
stoichiometry: 1.0
species: metaid_0000043
type: SpeciesReference

818901
stoichiometry: 1.0
species: metaid_0000046
type: SpeciesReference

metaid_0000030
constant: true
value: 0.01
type: Parameter

W3 CDTF: Thu Apr 05 09:42:03 BST 2007

metaid_0000025
constant: true
value: 0.0133
type: Parameter

metaid_0000075
kinetic law: 818733
reactant: 818721
is version of: GO:0008054
fast: false
reversible: false
name: cyclin degradation
type: Reaction

metaid_0000007
constant: true
value: 1.0
type: Parameter

818601
stoichiometry: 1.0
species: metaid_0000042
type: SpeciesReference

metaid_0000045
is version of: P47817
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: metaid_0000037
name: phosphorylated wee1
type: Species

metaid_0000050
is version of: P47817
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: metaid_0000037
name: wee1
type: Species

818805
stoichiometry: 1.0
species: metaid_0000045
type: SpeciesReference

metaid_0000136
constant: false
value: 0.0
type: Parameter

818373
stoichiometry: 1.0
species: metaid_0000040
type: SpeciesReference

metaid_0000066
kinetic law: 818457
product: 818445
reactant: 818433
is version of: GO:0045737
fast: false
reversible: false
name: Thr161 phosphorylation
type: Reaction

metaid_0000036
constant: true
value: 0.01
type: Parameter

818433
stoichiometry: 1.0
species: metaid_0000040
type: SpeciesReference

metaid_0000064
kinetic law: 818385
product: 818373
reactant: 818361
is version of: GO:0045736
fast: false
reversible: false
name: Thr161 dephosphorylation
type: Reaction

metaid_0000004
constant: true
value: 1.0
type: Parameter

metaid_0000026
constant: true
value: 0.3
type: Parameter

818745
stoichiometry: 1.0
species: metaid_0000044
type: SpeciesReference

W3 CDTF: Thu Jul 05 15:43:50 BST 2012

818505
stoichiometry: 1.0
species: metaid_0000040
type: SpeciesReference

818325
stoichiometry: 1.0
species: metaid_0000040
type: SpeciesReference

metaid_0000046
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: metaid_0000037
name: phosphorylated intermediary enzyme
type: Species

818661
stoichiometry: 1.0
species: metaid_0000043
type: SpeciesReference

metaid_0000079
kinetic law: 818853
reactant: 818841
fast: false
reversible: false
name: wee1 activation
type: Reaction

818289
stoichiometry: 1.0
species: metaid_0000039
type: SpeciesReference

metaid_0000084
unit: 818240
name: nanomole
type: SBMLUnitsDef

metaid_0000037
is: GO:0005737
constant: true
size: 1.0
spatial dimensions: 3.0
name: cytoplasm
type: Compartment

metaid_0000063
kinetic law: 818349
modifier: 818337
product: 818325
reactant: 818313
is version of: GO:0030332
fast: false
reversible: false
name: cyclin-cdc2 dimer formation
type: Reaction

metaid_0000027
constant: true
value: 0.1
type: Parameter

metaid_0000005
constant: true
value: 1.0
type: Parameter

818565
stoichiometry: 1.0
species: metaid_0000042
type: SpeciesReference

818252
exponent: 1.0
scale: 0
multipler: 60.0
kind: SECOND
type: SBMLUnit

818445
stoichiometry: 1.0
species: metaid_0000041
type: SpeciesReference

818926
stoichiometry: 1.0
species: metaid_0000047
type: SpeciesReference

metaid_0000047
is version of: GO:0031371
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: metaid_0000037
name: ubiquitin conjugating enzyme
type: Species

metaid_0000078
kinetic law: 818829
modifier: 818817
product: 818805
is version of: GO:0044257
is: http://identifiers.org/ec-code/2.7.11.22
fast: false
reversible: false
name: wee1 deactivation
type: Reaction

metaid_0000083
kinetic law: 818974
reactant: 818962
fast: false
reversible: false
name: ubiquitin conjugating enzyme deactivation
type: Reaction

818865
stoichiometry: 1.0
species: metaid_0000046
type: SpeciesReference

metaid_0000070
kinetic law: 818577
reactant: 818565
is version of: GO:0008054
fast: false
reversible: false
name: cyclin degradation
type: Reaction

metaid_0000081
kinetic law: 818913
reactant: 818901
is version of: GO:0044257
fast: false
reversible: false
name: intermediary enzyme deactivation
type: Reaction

metaid_0000072
type: Reaction
fast: false
name: Tyr15 phosphorylation
is: http://identifiers.org/ec-code/2.7.10.2
reversible: false
kinetic law: 818649
is version of: GO:0045736
reactant: 818625
product: 818637
is version of: REACT 6178

metaid_0000062
kinetic law: 818302
reactant: 818289
is version of: GO:0008054
fast: false
reversible: false
name: cyclin degradation
type: Reaction

818697
stoichiometry: 1.0
species: metaid_0000043
type: SpeciesReference

metaid_0000034
constant: true
value: 0.01
type: Parameter

metaid_0000015
constant: true
value: 0.015
type: Parameter

metaid_0000017
constant: true
value: 1.0
type: Parameter

818637
stoichiometry: 1.0
species: metaid_0000043
type: SpeciesReference

metaid_0000048
is version of: P35567
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: metaid_0000037
name: cdc2
type: Species

metaid_0000082
kinetic law: 818950
modifier: 818938
product: 818926
fast: false
reversible: false
name: ubiquitin conjugating enzyme activation
type: Reaction

ORG:
  orgname: California Institute of Technology
n:
  given: Harish
  family: Dharuri

metaid_0000071
kinetic law: 818613
product: 818601
reactant: 818589
is version of: GO:0000079
fast: false
reversible: false
name: Thr161 dephosphorylation
type: Reaction

metaid_0000061
kinetic law: 818277
product: 818264
is version of: GO:0006412
fast: false
reversible: false
name: cyclin synthesis
type: Reaction

metaid_0000137
constant: false
value: 0.0
type: Parameter

metaid_0000035
constant: true
value: 0.095
type: Parameter

metaid_0000016
constant: true
value: 1.0
type: Parameter

metaid_0000014
constant: false
value: 0.0
type: Parameter

metaid_0000040
initial concentration: 0.0
type: Species
in compartment: metaid_0000037
has part: P35567
has part: IPR015454
name: cyclin-cdc2 dimer
constant: false
initial amount: NaN
boundary condition: false
has only substance units: false

818781
stoichiometry: 1.0
species: metaid_0000044
type: SpeciesReference

metaid_0000049
is version of: P30311
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: metaid_0000037
name: cdc25
type: Species

metaid_0000020
constant: true
value: 0.25
type: Parameter

metaid_0000074
kinetic law: 818709
reactant: 818697
is version of: GO:0008054
fast: false
reversible: false
name: cyclin degradation
type: Reaction

metaid_0000069
kinetic law: 818553
product: 818541
reactant: 818529
is version of: GO:0000079
fast: false
reversible: false
name: Thr161 phosphorylation
type: Reaction

BIOMD0000000107
parameter: metaid_0000003
substance units: metaid_0000084
notes: The model reproduces the time profile of active MPF at cyclin concentration of 100nM as depicted in Fig 4A of the paper. Please note that active MPF and cyclin concentrations in the paper are given relative to total cdc2 concentration (100nM). Active MPF (dimer_p) is the cyclin-cdc2 complex that is phosphorylated at Thr161. The model was successfully tested on MathSBML and Jarnac. To the extent possible under law, all copyright and related or neighbouring rights to this encoded model have been dedicated to the public domain worldwide. Please refer to CC0 Public Domain Dedication for more information. In summary, you are entitled to use this encoded model in absolutely any manner you deem suitable, verbatim, or with modification, alone or embedded it in a larger context, redistribute it, commercially or not, in a restricted way or not. To cite BioModels Database, please use: Li C, Donizelli M, Rodriguez N, Dharuri H, Endler L, Chelliah V, Li L, He E, Henry A, Stefan MI, Snoep JL, Hucka M, Le Novère N, Laibe C (2010) BioModels Database: An enhanced, curated and annotated resource for published quantitative kinetic models. BMC Syst Biol., 4:92.
species: metaid_0000045
units def: metaid_0000084
parameter: metaid_0000027
reaction: metaid_0000074
species: metaid_0000046
rule: metaid_0000057
parameter: metaid_0000004
reaction: metaid_0000078
rule: metaid_0000056
species: metaid_0000041
reaction: metaid_0000082
is version of: GO:0000278
reaction: metaid_0000062
parameter: metaid_0000008
parameter: metaid_0000028
occurs in: http://identifiers.org/taxonomy/8292
reaction: metaid_0000066
species: metaid_0000042
parameter: metaid_0000011
parameter: metaid_0000016
parameter: metaid_0000031
parameter: metaid_0000007
reaction: metaid_0000065
parameter: metaid_0000035
reaction: metaid_0000069
parameter: metaid_0000010
parameter: metaid_0000023
parameter: metaid_0000014
reaction: metaid_0000070
species: metaid_0000048
is homolog to: REACT 152
parameter: metaid_0000026
reaction: metaid_0000073
rule: metaid_0000059
rule: metaid_0000058
reaction: metaid_0000077
time units: metaid_0000086
reaction: metaid_0000081
reaction: metaid_0000061
length unit: length
species: metaid_0000047
species: metaid_0000051
reaction: metaid_0000076
parameter: metaid_0000006
rule: metaid_0000053
reaction: metaid_0000064
parameter: metaid_0000019
curated: true
parameter: metaid_0000034
reaction: metaid_0000068
parameter: metaid_0000022
parameter: metaid_0000013
parameter: metaid_0000018
species: metaid_0000050
parameter: metaid_0000021
species: metaid_0000049
units def: metaid_0000086
parameter: metaid_0000025
type: SBMLModel
rule: metaid_0000060
reaction: metaid_0000072
species: metaid_0000044
species: metaid_0000043
reaction: metaid_0000080
parameter: metaid_0000136
species: metaid_0000040
is: MODEL5876465734
reaction: metaid_0000075
rule: metaid_0000055
is described by: http://identifiers.org/pubmed/8126097
volume units: metaid_0000004
parameter: metaid_0000005
reaction: metaid_0000079
rule: metaid_0000054
species: metaid_0000052
parameter: metaid_0000137
reaction: metaid_0000083

metaid_0000022
constant: true
value: 0.1
type: Parameter

metaid_0000008
constant: false
value: 0.0
type: Parameter

818493
stoichiometry: 1.0
species: metaid_0000042
type: SpeciesReference

metaid_0000041
in compartment: metaid_0000037
boundary condition: false
initial concentration: 0.0
has part: P35567
constant: false
initial amount: NaN
has only substance units: false
name: Thr161 phosphorylated dimer(active MPF)
type: Species
has part: IPR015454

818625
stoichiometry: 1.0
species: metaid_0000041
type: SpeciesReference

metaid_0000013
constant: true
value: 1.0
type: Parameter

metaid_0000031
constant: true
value: 0.087
type: Parameter

818264
stoichiometry: 1.0
species: metaid_0000039
type: SpeciesReference

metaid_0000029
constant: true
value: 0.0065
type: Parameter

metaid_0000021
constant: true
value: 0.01
type: Parameter

metaid_0000019
constant: true
value: 0.025
type: Parameter

818529
stoichiometry: 1.0
species: metaid_0000042
type: SpeciesReference

metaid_0000051
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: metaid_0000037
name: intermediary enzyme
type: Species

metaid_0000003
constant: true
value: 100.0
type: Parameter

818721
stoichiometry: 1.0
species: metaid_0000041
type: SpeciesReference

metaid_0000068
type: Reaction
is version of: GO:0045737
kinetic law: 818517
reversible: false
name: Tyr15 dephosphorylation
is: http://identifiers.org/ec-code/3.1.3.48
fast: false
reactant: 818493
product: 818505
is version of: REACT 6257.1

metaid_0000073
reactant: 818661
reversible: false
type: Reaction
fast: false
kinetic law: 818685
is version of: GO:0045737
product: 818673
is version of: REACT 6257.1
is: http://identifiers.org/ec-code/3.1.3.48
name: Tyr15 dephosphorylation

metaid_0000023
constant: true
value: 0.125
type: Parameter

818361
stoichiometry: 1.0
species: metaid_0000041
type: SpeciesReference

metaid_0000080
kinetic law: 818889
modifier: 818877
product: 818865
is: http://identifiers.org/ec-code/2.7.11.22
fast: false
reversible: false
name: intermediary enzyme activation
type: Reaction

818469
stoichiometry: 1.0
species: metaid_0000040
type: SpeciesReference

818841
stoichiometry: 1.0
species: metaid_0000045
type: SpeciesReference

metaid_0000033
constant: true
value: 0.1
type: Parameter

metaid_0000009
constant: true
value: 0.1
type: Parameter

818397
stoichiometry: 1.0
species: metaid_0000040
type: SpeciesReference

metaid_0000042
initial concentration: 0.0
has only substance units: false
in compartment: metaid_0000037
has part: P35567
name: Tyr15 phosphorylated dimer
constant: false
initial amount: NaN
has part: IPR015454
boundary condition: false
type: Species

metaid_0000012
constant: true
value: 0.1
type: Parameter

metaid_0000018
constant: true
value: 0.01
type: Parameter

metaid_0000032
constant: true
value: 0.01
type: Parameter

metaid_0000028
constant: true
value: 0.3
type: Parameter

818541
stoichiometry: 1.0
species: metaid_0000043
type: SpeciesReference

metaid_0000052
is version of: GO:0031371
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: metaid_0000037
name: ubiquitin conjugating enzyme
type: Species

ORG:
  orgname: EMBL-EBI
n:
  given: Nicolas
  family: Le Novère