080038
stoichiometry: 1.0
species: metaid_0000071
type: SpeciesReference

metaid_0000093
is version of: GO:0004051
type: Reaction
reactant: 079471
is version of: http://identifiers.org/ec-code/1.13.11.34
reversible: true
modifier: 079544
kinetic law: 079556
modifier: 079532
modifier: 079520
modifier: 079508
product: 079483
name: 5-HPETE production
modifier: 079495
fast: false

metaid_0000108
kinetic law: 080086
reactant: 080074
is version of: GO:0044248
fast: false
reversible: false
name: TAX2 decay
type: Reaction

079942
stoichiometry: 1.0
species: metaid_0000072
type: SpeciesReference

metaid_0000095
modifier: 079664
modifier: 079688
is version of: http://identifiers.org/ec-code/1.13.11.34
name: LTA4 production
modifier: 079640
type: Reaction
kinetic law: 079700
product: 079628
reversible: true
modifier: 079676
modifier: 079652
is version of: GO:0004051
reactant: 079616
fast: false

079568
stoichiometry: 1.0
species: metaid_0000060
type: SpeciesReference

metaid_0000118
kinetic law: 080302
modifier: 080290
reactant: 080278
is version of: GO:0043086
fast: false
reversible: false
name: 5-LOX inhibition by x10
type: Reaction

ORG:
  orgname: Beijing National Laboratory for Molecular Sciences
n:
  given: Kun
  family: Yang

079483
stoichiometry: 1.0
species: metaid_0000060
type: SpeciesReference

079219
stoichiometry: 1.0
species: metaid_0000079
type: SpeciesReference

metaid_0000096
reactant: 079712
kinetic law: 079748
modifier: 079736
product: 079724
type: Reaction
fast: false
is version of: http://identifiers.org/ec-code/3.3.2.6
is version of: GO:0004463
name: LTB4 production
reversible: true

metaid_0000094
fast: false
kinetic law: 079604
is version of: GO:0047066
reversible: true
type: Reaction
name: 5-HETE production
modifier: 079592
is version of: http://identifiers.org/ec-code/1.11.1.12
product: 079580
reactant: 079568

metaid_0000107
kinetic law: 080062
modifier: 080050
reactant: 080038
is version of: GO:0043086
fast: false
reversible: false
name: TXAS inhibition by PGH2
type: Reaction

metaid_0000117
kinetic law: 080266
modifier: 080254
reactant: 080242
is version of: GO:0043086
fast: false
reversible: false
name: 5-LOX inhibition by x12
type: Reaction

metaid_0000056
constant: true
value: 500.0
type: Parameter

metaid_0000080
has only substance units: false
initial amount: NaN
is: CHEBI:15554
in compartment: metaid_0000058
constant: false
is: C00427
boundary condition: false
type: Species
name: PGH2
initial concentration: 0.001

080098
stoichiometry: 1.0
species: metaid_0000063
type: SpeciesReference

079580
stoichiometry: 1.0
species: metaid_0000061
type: SpeciesReference

metaid_0000106
kinetic law: 080026
reactant: 080014
is version of: GO:0044248
fast: false
reversible: false
name: TXB2 decay
type: Reaction

metaid_0000097
kinetic law: 079821
is version of: http://identifiers.org/ec-code/1.14.13.30
type: Reaction
product: 079772
modifier: 079809
modifier: 079784
reversible: true
reactant: 079760
modifier: 079796
is version of: GO:0050051
fast: false
name: 20-OH-LTB4 production

metaid_0000069
is: Q9H7Z7
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.5
initial amount: NaN
in compartment: metaid_0000058
name: PGES
type: Species

metaid_0000091
fast: false
is version of: GO:0004796
kinetic law: 079423
reversible: true
type: Reaction
reactant: 079387
product: 079399
is version of: http://identifiers.org/ec-code/5.3.99.5
name: TXA2 production
modifier: 079411

metaid_0000081
is: CHEBI:15551
type: Species
initial concentration: 0.001
initial amount: NaN
constant: false
boundary condition: false
in compartment: metaid_0000058
has only substance units: false
name: PGE2
is: C00584

metaid_0000059
boundary condition: false
initial amount: NaN
is: C00219
constant: false
is: CHEBI:15843
has only substance units: false
name: AA
in compartment: metaid_0000058
initial concentration: 0.001
type: Species

080352
stoichiometry: 1.0
species: metaid_0000059
type: SpeciesReference

080146
stoichiometry: 1.0
species: metaid_0000077
type: SpeciesReference

079207
stoichiometry: 1.0
species: metaid_0000078
type: SpeciesReference

metaid_0000099
kinetic law: 079858
modifier: 079845
product: 079833
is version of: GO:0045893
fast: false
reversible: false
name: 15-LOX upregulation
type: Reaction

metaid_0000068
is version of: P35354
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.2
initial amount: NaN
in compartment: metaid_0000058
name: COX-2
type: Species

metaid_0000092
kinetic law: 079459
modifier: 079447
product: 079435
fast: false
reversible: false
name: TXB2 production
type: Reaction

metaid_0000058
is version of: GO:0005623
constant: true
size: 1.0
spatial dimensions: 3.0
name: cell
type: Compartment

metaid_0000082
name: TXA2
initial concentration: 0.001
initial amount: NaN
constant: false
in compartment: metaid_0000058
has only substance units: false
is: CHEBI:15627
boundary condition: false
is: C02198
type: Species

metaid_0000119
kinetic law: 080340
modifier: 080328
reactant: 080315
is version of: GO:0043086
fast: false
reversible: false
name: 5-LOX inhibition by x2
type: Reaction

metaid_0000105
kinetic law: 080002
modifier: 079990
reactant: 079978
is version of: GO:0043086
fast: false
reversible: false
name: LTA4H inhibition
type: Reaction

metaid_0000019
constant: true
value: 20.0
name: Km(LTA4H)
type: Parameter

metaid_0000029
constant: true
value: 0.07
type: Parameter

metaid_0000104
kinetic law: 079966
modifier: 079954
product: 079942
is version of: GO:0043085
fast: false
reversible: false
name: 5-LOX upregulation
type: Reaction

079616
stoichiometry: 1.0
species: metaid_0000060
type: SpeciesReference

079267
stoichiometry: 1.0
species: metaid_0000080
type: SpeciesReference

metaid_0000114
unit: 078953
name: minute
type: SBMLUnitsDef

metaid_0000040
constant: true
value: 0.175
type: Parameter

metaid_0000070
boundary condition: false
initial concentration: 0.001
is: C05966
has only substance units: false
in compartment: metaid_0000058
constant: false
name: 15-HPETE
type: Species
is: CHEBI:15628
initial amount: NaN

metaid_0000028
constant: true
value: 0.001
type: Parameter

metaid_0000018
constant: true
value: 125.0
name: Kcat(LTA4H)
type: Parameter

079255
stoichiometry: 1.0
species: metaid_0000059
type: SpeciesReference

079098
stoichiometry: 1.0
species: metaid_0000070
type: SpeciesReference

080218
stoichiometry: 1.0
species: metaid_0000061
type: SpeciesReference

metaid_0000030
constant: true
value: 0.01
type: Parameter

metaid_0000103
kinetic law: 079930
modifier: 079918
reactant: 079906
is version of: GO:0043086
fast: false
reversible: false
name: TXAS inhibition
type: Reaction

metaid_0000090
name: PGE2 production
modifier: 079339
modifier: 079363
is version of: http://identifiers.org/ec-code/5.3.99.3
type: Reaction
product: 079327
reversible: true
reactant: 079315
is version of: GO:0050220
kinetic law: 079375
fast: false
modifier: 079351

metaid_0000113
kinetic law: 080182
reactant: 080170
is version of: GO:0044248
fast: false
reversible: false
name: 15-HPETE decay
type: Reaction

metaid_0000041
constant: true
value: 0.01
type: Parameter

metaid_0000017
constant: true
value: 5.0
name: Km(5-LOX)
type: Parameter

080315
stoichiometry: 1.0
species: metaid_0000072
type: SpeciesReference

metaid_0000003
constant: true
value: 12.0
name: lin
type: Parameter

080074
stoichiometry: 1.0
species: metaid_0000082
type: SpeciesReference

metaid_0000116
kinetic law: 080230
reactant: 080218
is version of: GO:0044248
fast: false
reversible: false
name: 5-HETE decay
type: Reaction

metaid_0000042
constant: true
value: 15.0
type: Parameter

metaid_0000016
constant: true
value: 5000.0
name: Kcat(5-LOX)
type: Parameter

metaid_0000043
constant: true
value: 6.3
type: Parameter

080122
stoichiometry: 1.0
species: metaid_0000062
type: SpeciesReference

metaid_0000115
kinetic law: 080206
reactant: 080194
is version of: GO:0030163
fast: false
reversible: false
name: 15-LOX decay
type: Reaction

metaid_0000044
constant: true
value: 0.2
type: Parameter

079870
stoichiometry: 1.0
species: metaid_0000067
type: SpeciesReference

metaid_0000034
constant: true
value: 30.0
type: Parameter

079906
stoichiometry: 1.0
species: metaid_0000071
type: SpeciesReference

079110
stoichiometry: 1.0
species: metaid_0000077
type: SpeciesReference

metaid_0000077
in compartment: metaid_0000058
has only substance units: false
constant: false
initial concentration: 0.001
is: C04742
is: CHEBI:15558
name: 15-HETE
type: Species
initial amount: NaN
boundary condition: false

metaid_0000014
constant: true
value: 1599.0
name: Kcat(TXAS)
type: Parameter

metaid_0000004
notes: upper case K
constant: true
value: 3600.0
name: Kcat(PLA2)
type: Parameter

metaid_0000062
is: CHEBI:15651
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.001
initial amount: NaN
in compartment: metaid_0000058
name: LTA4
type: Species

079435
stoichiometry: 1.0
species: metaid_0000083
type: SpeciesReference

metaid_0000024
constant: true
value: 0.05
type: Parameter

079724
stoichiometry: 1.0
species: metaid_0000063
type: SpeciesReference

metaid_0000110
kinetic law: 080134
reactant: 080122
is version of: GO:0044248
fast: false
reversible: false
name: LTA4 decay
type: Reaction

metaid_0000045
constant: true
value: 0.86
type: Parameter

080170
stoichiometry: 1.0
species: metaid_0000070
type: SpeciesReference

metaid_0000035
constant: true
value: 0.6
type: Parameter

metaid_0000100
kinetic law: 079894
modifier: 079882
reactant: 079870
is version of: GO:0043086
fast: false
reversible: false
name: 12-LOX inhibition
type: Reaction

BIOMD0000000106
parameter: metaid_0000032
parameter: metaid_0000027
parameter: metaid_0000012
reaction: metaid_0000111
species: metaid_0000070
parameter: metaid_0000054
parameter: metaid_0000056
reaction: metaid_0000109
species: metaid_0000072
parameter: metaid_0000035
species: metaid_0000071
parameter: metaid_0000015
reaction: metaid_0000092
species: metaid_0000082
reaction: metaid_0000095
units def: metaid_0000112
parameter: metaid_0000004
parameter: metaid_0000028
is version of: GO:0019369
parameter: metaid_0000007
name: Yang2007_ArachidonicAcid
species: metaid_0000069
species: metaid_0000068
length unit: length
notes: This model is according to the paper Dynamic Simulation on the Arachidonic Acid Metabolic Network . Figure 2A has been reproduced by SBML ode solver on line. In the original model, all the reactions are presented as ODE directly. So curator rewrite each reaction according to the semantics of the paper. In this paper, the authors used quict complex kinetics law to describe the catalysis in the network, curators did not necessarily know all the complete meanings of the paper. To the extent possible under law, all copyright and related or neighbouring rights to this encoded model have been dedicated to the public domain worldwide. Please refer to CC0 Public Domain Dedication for more information. In summary, you are entitled to use this encoded model in absolutely any manner you deem suitable, verbatim, or with modification, alone or embedded it in a larger context, redistribute it, commercially or not, in a restricted way or not. To cite BioModels Database, please use: Li C, Donizelli M, Rodriguez N, Dharuri H, Endler L, Chelliah V, Li L, He E, Henry A, Stefan MI, Snoep JL, Hucka M, Le Novère N, Laibe C (2010) BioModels Database: An enhanced, curated and annotated resource for published quantitative kinetic models. BMC Syst Biol., 4:92.
parameter: metaid_0000020
species: metaid_0000065
parameter: metaid_0000038
parameter: metaid_0000016
reaction: metaid_0000117
parameter: metaid_0000023
species: metaid_0000077
parameter: metaid_0000050
parameter: metaid_0000019
reaction: metaid_0000105
time units: metaid_0000114
parameter: metaid_0000011
reaction: metaid_0000110
is described by: http://identifiers.org/pubmed/17381237
reaction: metaid_0000108
reaction: metaid_0000086
species: metaid_0000060
parameter: metaid_0000041
species: metaid_0000078
reaction: metaid_0000089
parameter: metaid_0000046
parameter: metaid_0000031
parameter: metaid_0000026
parameter: metaid_0000053
species: metaid_0000061
parameter: metaid_0000049
parameter: metaid_0000034
parameter: metaid_0000014
reaction: metaid_0000113
reaction: metaid_0000091
species: metaid_0000074
parameter: metaid_0000037
species: metaid_0000073
reaction: metaid_0000121
reaction: metaid_0000116
reaction: metaid_0000094
reaction: metaid_0000097
reaction: metaid_0000104
parameter: metaid_0000006
is: MODEL8610058649
substance units: metaid_0000112
parameter: metaid_0000009
parameter: metaid_0000040
parameter: metaid_0000022
species: metaid_0000067
species: metaid_0000066
parameter: metaid_0000018
reaction: metaid_0000119
species: metaid_0000063
parameter: metaid_0000043
parameter: metaid_0000045
parameter: metaid_0000025
parameter: metaid_0000010
species: metaid_0000079
occurs in: http://identifiers.org/taxonomy/9606

metaid_0000075
is: P36969
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.8
initial amount: NaN
in compartment: metaid_0000058
name: PHGPx
type: Species

metaid_0000076
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: metaid_0000058
name: exo-AA
type: Species

metaid_0000005
notes: lower case k
constant: true
value: 2600.0
name: Km(PLA2)
type: Parameter

metaid_0000015
constant: true
value: 4.0
name: Km(TXAS)
type: Parameter

079159
stoichiometry: 1.0
species: metaid_0000078
type: SpeciesReference

metaid_0000061
in compartment: metaid_0000058
type: Species
is: CHEBI:28209
initial concentration: 0.001
is: C04805
boundary condition: false
name: 5-HETE
has only substance units: false
constant: false
initial amount: NaN

metaid_0000025
constant: true
value: 0.01
type: Parameter

metaid_0000111
kinetic law: 080158
reactant: 080146
is version of: GO:0044248
fast: false
reversible: false
name: 15-HETE decay
type: Reaction

metaid_0000046
constant: true
value: 10.0
type: Parameter

079760
stoichiometry: 1.0
species: metaid_0000063
type: SpeciesReference

metaid_0000032
constant: true
value: 0.3
type: Parameter

080278
stoichiometry: 1.0
species: metaid_0000072
type: SpeciesReference

metaid_0000006
constant: true
value: 1000.0
name: Kcat(15-LOX)
type: Parameter

metaid_0000031
constant: true
value: 0.01
type: Parameter

metaid_0000050
constant: true
value: 200.0
type: Parameter

metaid_0000079
boundary condition: false
in compartment: metaid_0000058
is: CHEBI:34146
has only substance units: false
initial concentration: 0.001
name: 12-HETE
is: C14777
initial amount: NaN
type: Species
constant: false

metaid_0000012
constant: true
value: 3000.0
name: Kcat(PGES)
type: Parameter

metaid_0000060
name: 5-HPETE
is: C05356
boundary condition: false
in compartment: metaid_0000058
constant: false
type: Species
initial concentration: 0.001
has only substance units: false
initial amount: NaN
is: CHEBI:15632

metaid_0000089
modifier: 079279
fast: false
type: Reaction
product: 079267
is version of: http://identifiers.org/ec-code/1.14.99.1
kinetic law: 079303
modifier: 079291
reversible: true
reactant: 079255
is version of: GO:0004666
name: PGH2 production

079049
stoichiometry: 1.0
species: metaid_0000059
type: SpeciesReference

metaid_0000026
constant: true
value: 0.1
type: Parameter

metaid_0000112
unit: 078941
name: micromole
type: SBMLUnitsDef

metaid_0000047
constant: true
value: 10.0
type: Parameter

079712
stoichiometry: 1.0
species: metaid_0000062
type: SpeciesReference

metaid_0000033
constant: true
value: 30.0
type: Parameter

078965
stoichiometry: 1.0
species: metaid_0000059
type: SpeciesReference

metaid_0000013
constant: true
value: 160.0
name: Km(PGES)
type: Parameter

metaid_0000078
initial amount: NaN
is: C05965
type: Species
constant: false
in compartment: metaid_0000058
name: 12-HPETE
is: CHEBI:15626
has only substance units: false
initial concentration: 0.001
boundary condition: false

metaid_0000088
type: Reaction
reactant: 079207
modifier: 079231
name: 12-HETE production
kinetic law: 079243
is version of: http://identifiers.org/ec-code/1.11.1.12
reversible: true
fast: false
is version of: GO:0047066
product: 079219

079978
stoichiometry: 1.0
species: metaid_0000073
type: SpeciesReference

metaid_0000007
constant: true
value: 70.0
name: Km(15-LOX)
type: Parameter

metaid_0000027
constant: true
value: 0.001
type: Parameter

metaid_0000038
constant: true
value: 30.0
type: Parameter

metaid_0000072
is: P09917
constant: false
boundary condition: false
has only substance units: false
initial concentration: 5.0
initial amount: NaN
in compartment: metaid_0000058
name: 5-LOX
type: Species

metaid_0000086
reactant: 079098
is version of: GO:0047066
name: 15-HETE production
fast: false
reversible: true
modifier: 079122
kinetic law: 079134
is version of: http://identifiers.org/ec-code/1.11.1.12
type: Reaction
product: 079110

metaid_0000048
constant: true
value: 10.0
type: Parameter

079833
stoichiometry: 1.0
species: metaid_0000066
type: SpeciesReference

metaid_0000067
is: P18054
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.5
initial amount: NaN
in compartment: metaid_0000058
name: 12-LOX
type: Species

metaid_0000008
constant: true
value: 1000.0
name: Kcat(12-LOX)
type: Parameter

metaid_0000087
type: Reaction
is version of: GO:0004052
fast: false
product: 079159
name: 12-HPETE production
modifier: 079183
modifier: 079171
is version of: http://identifiers.org/ec-code/1.13.11.31
reactant: 079146
kinetic law: 079195
reversible: true

metaid_0000010
constant: true
value: 1000.0
name: Kcat(COX-2)
type: Parameter

metaid_0000052
constant: true
value: 500.0
type: Parameter

079315
stoichiometry: 1.0
species: metaid_0000080
type: SpeciesReference

079772
stoichiometry: 1.0
species: metaid_0000064
type: SpeciesReference

metaid_0000071
is: P24557
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.5
initial amount: NaN
in compartment: metaid_0000058
name: TXAS
type: Species

079628
stoichiometry: 1.0
species: metaid_0000062
type: SpeciesReference

metaid_0000039
constant: true
value: 4.0
type: Parameter

metaid_0000049
constant: true
value: 500.0
type: Parameter

080194
stoichiometry: 1.0
species: metaid_0000066
type: SpeciesReference

metaid_0000020
constant: true
value: 150.0
name: Kcat(CYP4F3)
type: Parameter

metaid_0000085
reactant: 079049
type: Reaction
fast: false
is version of: GO:0050473
kinetic law: 079086
modifier: 079073
name: 15-HPETE production
is version of: http://identifiers.org/ec-code/1.13.11.33
product: 079061
reversible: true

metaid_0000066
is: P16050
constant: false
boundary condition: false
has only substance units: false
initial concentration: 1.5
initial amount: NaN
in compartment: metaid_0000058
name: 15-LOX
type: Species

079061
stoichiometry: 1.0
species: metaid_0000070
type: SpeciesReference

078953
exponent: 1.0
scale: 0
multipler: 60.0
kind: SECOND
type: SBMLUnit

080014
stoichiometry: 1.0
species: metaid_0000083
type: SpeciesReference

metaid_0000009
constant: true
value: 50.0
name: Km(12-LOX)
type: Parameter

metaid_0000021
constant: true
value: 3.9
name: Km(CYP4F3)
type: Parameter

metaid_0000011
constant: true
value: 50.0
name: Km(COX-2)
type: Parameter

metaid_0000051
constant: true
value: 500.0
type: Parameter

W3 CDTF: Thu Jul 05 15:48:14 BST 2012

metaid_0000036
constant: true
value: 0.1
type: Parameter

metaid_0000074
is: Q08477
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.07
initial amount: NaN
in compartment: metaid_0000058
name: CYP4F3
type: Species

metaid_0000055
constant: true
value: 0.15
type: Parameter

079387
stoichiometry: 1.0
species: metaid_0000080
type: SpeciesReference

metaid_0000065
is: P04054
constant: false
boundary condition: false
has only substance units: false
initial concentration: 1.5
initial amount: NaN
in compartment: metaid_0000058
name: PLA2
type: Species

metaid_0000084
reversible: false
product: 078965
kinetic law: 079037
modifier: 079025
is version of: http://identifiers.org/ec-code/3.1.1.4
modifier: 078989
name: AA production
modifier: 079001
fast: false
modifier: 078977
is version of: GO:0004623
modifier: 079013
type: Reaction

metaid_0000022
constant: true
value: 500.0
name: Kcat(PHGPx)
type: Parameter

metaid_0000064
is: CHEBI:15646
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.001
initial amount: NaN
in compartment: metaid_0000058
name: w-LTB4
type: Species

079327
stoichiometry: 1.0
species: metaid_0000081
type: SpeciesReference

079471
stoichiometry: 1.0
species: metaid_0000059
type: SpeciesReference

079146
stoichiometry: 1.0
species: metaid_0000059
type: SpeciesReference

metaid_0000121
kinetic law: 080364
reactant: 080352
is version of: GO:0044248
fast: false
reversible: false
name: AA decay
type: Reaction

metaid_0000073
is: P09960
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.76
initial amount: NaN
in compartment: metaid_0000058
name: LTA4H
type: Species

079399
stoichiometry: 1.0
species: metaid_0000082
type: SpeciesReference

metaid_0000037
constant: true
value: 0.01
type: Parameter

metaid_0000054
constant: true
value: 2.3E-5
type: Parameter

080242
stoichiometry: 1.0
species: metaid_0000072
type: SpeciesReference

metaid_0000109
kinetic law: 080110
reactant: 080098
is version of: GO:0044248
fast: false
reversible: false
name: LTB4 decay
type: Reaction

metaid_0000083
constant: false
has only substance units: false
in compartment: metaid_0000058
is: C05963
is: CHEBI:28728
type: Species
initial amount: NaN
initial concentration: 0.001
boundary condition: false
name: TXB2

metaid_0000023
constant: true
value: 70.0
name: Km(PHGPx)
type: Parameter

metaid_0000063
is: CHEBI:15647
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.001
initial amount: NaN
in compartment: metaid_0000058
name: LTB4
type: Species

078941
exponent: 1.0
scale: -6
multipler: 1.0
kind: MOLE
type: SBMLUnit

metaid_0000053
constant: true
value: 0.053
type: Parameter

orgname: BNMC

n:
  given: Enuo
  family: He

W3 CDTF: Fri Jan 12 15:06:16 GMT 2007