metaid_0000011
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: metaid_0000007
name: E2
type: Species

metaid_0000015
kinetic law: 893487
modifier: 893475
product: 893463
reactant: 893451
fast: false
reversible: false
name: X1->P
type: Reaction

893511
persistant: true
initial value: true
type: Trigger

893391
stoichiometry: 1.0
species: metaid_0000008
type: SpeciesReference

893451
stoichiometry: 1.0
species: metaid_0000009
type: SpeciesReference

893523
notes: at time=1, E1=0.4
variable: metaid_0000010
type: EventAssignment

metaid_0000008
constant: false
boundary condition: false
has only substance units: false
initial concentration: 1.0
initial amount: NaN
in compartment: metaid_0000007
name: S
type: Species

893463
stoichiometry: 1.0
species: metaid_0000012
type: SpeciesReference

metaid_0000018
notes: Etot=E1+E2 is constant.
constant: true
boundary condition: false
has only substance units: false
initial concentration: 1.0
initial amount: NaN
in compartment: metaid_0000007
name: Etot
type: Species

893439
value: 1.0
type: LocalParameter

metaid_0000010
constant: false
boundary condition: false
has only substance units: false
initial concentration: 1.0
initial amount: NaN
in compartment: metaid_0000007
name: E1
type: Species

metaid_0000012
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: metaid_0000007
name: P
type: Species

metaid_0000014
kinetic law: 893427
modifier: 893415
product: 893403
reactant: 893391
fast: false
reversible: false
name: S->X1
type: Reaction

BIOMD0000000104
species: metaid_0000011
species: metaid_0000012
curated: true
is version of: GO:0040029
substance units: metaid_0000113
type: SBMLModel
occurs in: http://identifiers.org/taxonomy/131567
is: MODEL4931762955
time units: metaid_0000037
species: metaid_0000009
creator:
  ORG:
    orgname: BNMC
  n:
    given: Enuo
    family: He
creator:
  ORG:
    orgname: EMBL-EBI
  n:
    given: Nicolas
    family: Le Novère
species: metaid_0000010
created:
  W3 CDTF: Mon Mar 26 10:35:54 BST 2007
rule: 785523
is version of: GO:0003824
reaction: metaid_0000014
modified:
  W3 CDTF: Thu Jul 05 15:44:59 BST 2012
area units: metaid_0000005
reaction: metaid_0000015
name: Klipp2002_MetabolicOptimization_linearPathway(n=2)
compartment: metaid_0000007
species: metaid_0000008
event: metaid_0000017
notes: This model is according to the paper Prediction of temporal gene expression metabolic optimization by re-distribution of enzyme activities. The model describe optimal enzyme profiles and meatbolite time courses for the linear metabolic pathway (n=2). Figure1 has been reproduced by roadRunner. The value for k1 and k2 have not explicitly given in the paper, but calculations were performed for equal catalytic efficiencies of the enzymes (ki=k). So curator gave k1=k2=1. Also enzyme concentrations are given in units of Etot; times are given in units of 1/(k*Etot) in the papaer, for simplicity , we use defalut units of the SBML to present the concentration and time. To the extent possible under law, all copyright and related or neighbouring rights to this encoded model have been dedicated to the public domain worldwide. Please refer to CC0 Public Domain Dedication for more information. In summary, you are entitled to use this encoded model in absolutely any manner you deem suitable, verbatim, or with modification, alone or embedded it in a larger context, redistribute it, commercially or not, in a restricted way or not. To cite BioModels Database, please use: Li C, Donizelli M, Rodriguez N, Dharuri H, Endler L, Chelliah V, Li L, He E, Henry A, Stefan MI, Snoep JL, Hucka M, Le Novère N, Laibe C (2010) BioModels Database: An enhanced, curated and annotated resource for published quantitative kinetic models. BMC Syst Biol., 4:92.
length unit: length
species: metaid_0000018
volume units: metaid_0000004
is described by: http://identifiers.org/pubmed/12423338

893499
value: 1.0
type: LocalParameter

893403
stoichiometry: 1.0
species: metaid_0000009
type: SpeciesReference

metaid_0000007
is version of: GO:0005623
constant: true
size: 1.0
spatial dimensions: 3.0
name: cell
type: Compartment

metaid_0000017
event assignment: 893523
trigger: 893511
notes: During the initial phase, t smaller than T1 (T1=1), the whole amount of protein is allocated to the first reaction(E1=Etot, E2=0). At the beginning of the second phase the concentration E2 undergoes an abrupt switch from zero to a finite vaule whereas the concentration E1 is descreased by the same extent.
use values from trigger time: true
name: single switch
type: Event

metaid_0000009
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: metaid_0000007
name: X1
type: Species