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fast: false
reversible: false
name: RI constitutive degradation
type: Reaction

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kinetic law: 943669
reactant: 943657
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fast: false
reversible: false
name: Ligand receptor complex constitutive degradation
type: Reaction

metaid_0000031
kinetic law: 943952
reactant: 943939
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fast: false
reversible: false
name: RII constitutive degradation
type: Reaction

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type: SpeciesReference

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BIOMD0000000101
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time units: metaid_0000037
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area units: metaid_0000005
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reaction: metaid_0000027
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type: SBMLModel
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curated: true
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occurs in: http://identifiers.org/taxonomy/131567
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notes: The model reproduces Fig 5A of the paper. The ligand concentration is increased from 3E-5 to 0.01 at time t=2500 to ensure that the system reaches steady state. Hence, the time t=0 of the paper corresponds to t=2500 in the model. The peak value of the active ligand receptor complex is off by a value of 1.25, the authors have stated that this discrepancy is due to the fact that the figure in the paper corresponds to a slightly different parameter set. The model was successfully tested on MathSBML. To the extent possible under law, all copyright and related or neighbouring rights to this encoded model have been dedicated to the public domain worldwide. Please refer to CC0 Public Domain Dedication for more information. In summary, you are entitled to use this encoded model in absolutely any manner you deem suitable, verbatim, or with modification, alone or embedded it in a larger context, redistribute it, commercially or not, in a restricted way or not. To cite BioModels Database, please use: Li C, Donizelli M, Rodriguez N, Dharuri H, Endler L, Chelliah V, Li L, He E, Henry A, Stefan MI, Snoep JL, Hucka M, Le Novère N, Laibe C (2010) BioModels Database: An enhanced, curated and annotated resource for published quantitative kinetic models. BMC Syst Biol., 4:92.
compartment: metaid_0000012
species: metaid_0000014
species: metaid_0000015
parameter: metaid_0000008
length unit: length
creator:
  ORG:
    orgname: California Institute of Technology
  n:
    given: Harish
    family: Dharuri
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reaction: metaid_0000025
species: metaid_0000020
reaction: metaid_0000033
has part: REACT 6844.3
volume units: metaid_0000004
parameter: metaid_0000006
has part: hsa04350
modified:
  W3 CDTF: Thu Jul 05 15:45:52 BST 2012
created:
  W3 CDTF: Tue Nov 28 18:39:38 GMT 2006
reaction: metaid_0000023
units def: metaid_0000037
units def: metaid_0000036
reaction: metaid_0000026
name: Vilar2006_TGFbeta
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reaction: metaid_0000029
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species: metaid_0000013
is described by: http://identifiers.org/pubmed/16446785

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metaid_0000030
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fast: false
reversible: false
name: RII synthesis
type: Reaction

metaid_0000027
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product: 943805
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value: 8.0
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fast: false
reversible: false
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metaid_0000011
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