178674
stoichiometry: 1.0
species: metaid_0000038
type: SpeciesReference

metaid_0000025
constant: true
units: metaid_0000055
value: 0.5
type: Parameter

178394
exponent: 1.0
scale: 0
multipler: 3600.0
kind: SECOND
type: SBMLUnit

metaid_0000051
kinetic law: 178686
reactant: 178674
is version of: GO:0032961
fast: false
reversible: false
name: Ca independent IP3 degradation
type: Reaction

178575
stoichiometry: 1.0
species: metaid_0000036
type: SpeciesReference

metaid_0000031
constant: true
units: metaid_0000055
value: 10000.0
type: Parameter

178334
exponent: 1.0
scale: -6
multipler: 1.0
kind: MOLE
type: SBMLUnit

metaid_0000059
constant: true
units: dimensionless
value: 2.0
type: Parameter

metaid_0000012
constant: true
units: metaid_0000055
value: 0.5
type: Parameter

178503
stoichiometry: 1.0
species: metaid_0000036
type: SpeciesReference

metaid_0000045
kinetic law: 178479
product: 178467
reactant: 178455
is version of: GO:0051481
is version of: GO:0032470
fast: false
reversible: false
name: Calcium transport to internal store
type: Reaction

178467
stoichiometry: 1.0
species: metaid_0000042
type: SpeciesReference

178636
stoichiometry: 1.0
species: metaid_0000038
type: SpeciesReference

metaid_0000024
constant: true
value: 0.1
type: Parameter

metaid_0000038
boundary condition: false
initial concentration: 0.45
has only substance units: false
initial amount: NaN
is: C01245
type: Species
in compartment: metaid_0000032
name: IP3
constant: false
is: CHEBI:16595

metaid_0000050
kinetic law: 178661
modifier: 178649
reactant: 178636
is version of: GO:0032961
fast: false
reversible: false
name: Ca-dependant IP3 degradation
type: Reaction

178418
stoichiometry: 1.0
species: metaid_0000035
type: SpeciesReference

metaid_0000030
constant: true
value: 0.2
type: Parameter

metaid_0000013
constant: true
units: metaid_0000058
value: 1.0
type: Parameter

metaid_0000058
unit: 178406
name: min_inv
type: SBMLUnitsDef

metaid_0000044
kinetic law: 178443
product: 178430
reactant: 178418
is version of: GO:0006816
is version of: GO:0007204
fast: false
reversible: false
name: Calcium Influx
type: Reaction

metaid_0000003
constant: true
units: metaid_0000056
value: 2.0
type: Parameter

metaid_0000027
constant: true
units: dimensionless
value: 9.0
type: Parameter

178611
stoichiometry: 1.0
species: metaid_0000038
type: SpeciesReference

178382
exponent: -1.0
scale: 0
multipler: 3600.0
kind: SECOND
type: SBMLUnit

metaid_0000014
constant: true
units: metaid_0000058
value: 10.0
type: Parameter

178430
stoichiometry: 1.0
species: metaid_0000036
type: SpeciesReference

178455
stoichiometry: 1.0
species: metaid_0000036
type: SpeciesReference

metaid_0000009
constant: true
units: dimensionless
value: 2.0
type: Parameter

metaid_0000057
unit: 178394
name: minutes
type: SBMLUnitsDef

metaid_0000047
kinetic law: 178563
product: 178551
reactant: 178539
is version of: GO:0007204
fast: false
reversible: false
name: Calcium leak
type: Reaction

178539
stoichiometry: 1.0
species: metaid_0000042
type: SpeciesReference

178406
exponent: -1.0
scale: 0
multipler: 3600.0
kind: SECOND
type: SBMLUnit

metaid_0000026
constant: true
units: metaid_0000058
value: 0.6
type: Parameter

178318
exponent: 1.0
scale: -6
multipler: 1.0
kind: MOLE
type: SBMLUnit

metaid_0000036
in compartment: metaid_0000032
type: Species
is: CHEBI:29108
name: Cytosolic Calcium
boundary condition: false
initial amount: NaN
constant: false
has only substance units: false
initial concentration: 0.0
is: C00076

metaid_0000008
constant: true
units: metaid_0000056
value: 20.0
type: Parameter

metaid_0000056
unit: 178382
unit: 178370
unit: 178358
name: uM_per_min
type: SBMLUnitsDef

metaid_0000015
constant: true
units: metaid_0000056
value: 2.0
type: Parameter

metaid_0000046
kinetic law: 178527
modifier: 178515
product: 178503
reactant: 178491
is version of: GO:0007204
fast: false
reversible: false
name: Calcium transport to cytosol
type: Reaction

metaid_0000007
constant: true
units: metaid_0000055
value: 0.1
type: Parameter

metaid_0000055
unit: 178346
unit: 178334
name: uM
type: SBMLUnitsDef

178358
exponent: 1.0
scale: -6
multipler: 1.0
kind: MOLE
type: SBMLUnit

metaid_0000021
constant: true
units: metaid_0000058
value: 1.5
type: Parameter

metaid_0000035
boundary condition: true
is: CHEBI:29108
has only substance units: false
type: Species
initial concentration: 1000.0
initial amount: NaN
constant: false
name: Extracellular Calcium
in compartment: metaid_0000034
is: C00076

metaid_0000017
constant: true
units: dimensionless
value: 4.0
type: Parameter

178551
stoichiometry: 1.0
species: metaid_0000036
type: SpeciesReference

178698
stoichiometry: 1.0
species: metaid_0000043
type: SpeciesReference

178370
exponent: -1.0
scale: 0
multipler: 1.0
kind: LITRE
type: SBMLUnit

metaid_0000049
kinetic law: 178624
product: 178611
is version of: GO:0032959
fast: false
reversible: false
name: Agonist stimulated production of IP3
type: Reaction

metaid_0000028
constant: true
units: metaid_0000055
value: 10000.0
type: Parameter

metaid_0000006
constant: true
units: metaid_0000056
value: 6.0
type: Parameter

metaid_0000054
unit: 178318
name: micromole
type: SBMLUnitsDef

metaid_0000034
is: GO:0005615
constant: true
size: 1.0
spatial dimensions: 3.0
type: Compartment

metaid_0000020
constant: true
units: metaid_0000058
value: 0.1
type: Parameter

metaid_0000016
constant: true
units: metaid_0000056
value: 30.0
type: Parameter

metaid_0000048
kinetic law: 178599
product: 178587
reactant: 178575
is version of: GO:0051481
fast: false
reversible: false
name: Calcium efflux
type: Reaction

178587
stoichiometry: 1.0
species: metaid_0000035
type: SpeciesReference

metaid_0000029
constant: true
units: metaid_0000055
value: 10000.0
type: Parameter

metaid_0000053
kinetic law: 178746
reactant: 178734
is: GO:0050196
is: http://identifiers.org/ec-code/3.1.3.17
fast: false
reversible: false
name: Phosphatase activity
type: Reaction

metaid_0000005
constant: true
units: dimensionless
value: 0.5
type: Parameter

metaid_0000019
constant: true
units: metaid_0000055
value: 0.4
type: Parameter

178346
exponent: -1.0
scale: 0
multipler: 1.0
kind: LITRE
type: SBMLUnit

metaid_0000043
is version of: P11216
constant: false
boundary condition: false
has only substance units: false
initial concentration: 1.0
initial amount: NaN
in compartment: metaid_0000032
name: Glycogen Phosphorylase
type: Species

metaid_0000033
is version of: GO:0005783
constant: true
size: 1.0
spatial dimensions: 3.0
type: Compartment

metaid_0000023
constant: true
units: metaid_0000055
value: 0.5
type: Parameter

178491
stoichiometry: 1.0
species: metaid_0000042
type: SpeciesReference

metaid_0000010
constant: true
units: metaid_0000055
value: 0.2
type: Parameter

metaid_0000004
constant: true
units: metaid_0000056
value: 2.0
type: Parameter

metaid_0000022
constant: true
units: dimensionless
value: 9.0
type: Parameter

metaid_0000052
kinetic law: 178722
modifier: 178710
product: 178698
is: GO:0004689
is: http://identifiers.org/ec-code/2.7.11.19
fast: false
reversible: false
name: Phosphorylase kinase activity
type: Reaction

metaid_0000042
is: CHEBI:29108
type: Species
in compartment: metaid_0000033
is: C00076
name: Intravesicular Calcium
boundary condition: false
has only substance units: false
initial amount: NaN
constant: false
initial concentration: 0.36

metaid_0000018
constant: true
units: metaid_0000055
value: 1.0
type: Parameter

metaid_0000032
is: GO:0005829
constant: true
size: 1.0
spatial dimensions: 3.0
type: Compartment

BIOMD0000000100
is version of: GO:0048016
curated: true
parameter: metaid_0000012
species: metaid_0000038
units def: metaid_0000055
created:
  W3 CDTF: Thu Mar 22 10:28:32 GMT 2007
is: MODEL4589754842
modified:
  W3 CDTF: Thu Jul 19 18:29:27 BST 2012
parameter: metaid_0000024
parameter: metaid_0000019
parameter: metaid_0000025
parameter: metaid_0000011
parameter: metaid_0000006
parameter: metaid_0000007
reaction: metaid_0000046
reaction: metaid_0000047
species: metaid_0000035
compartment: metaid_0000033
parameter: metaid_0000009
creator:
  ORG:
    orgname: California Institute of Technology
  n:
    given: Harish
    family: Dharuri
units def: metaid_0000058
notes: The model reproduces the temporal evolution of Glycogen phosphorylase for a vale of Vm5=30 as depicted in Fig 1a of the paper. The model makes use of calcium oscillations from the Borghans model to stimulate the activation of glycogen phosphorylase. Hence, this is a simple extension of the Borghans model. The model was succesfully tested on MathSBML and Jarnac. To the extent possible under law, all copyright and related or neighbouring rights to this encoded model have been dedicated to the public domain worldwide. Please refer to CC0 Public Domain Dedication for more information. In summary, you are entitled to use this encoded model in absolutely any manner you deem suitable, verbatim, or with modification, alone or embedded it in a larger context, redistribute it, commercially or not, in a restricted way or not. To cite BioModels Database, please use: Li C, Donizelli M, Rodriguez N, Dharuri H, Endler L, Chelliah V, Li L, He E, Henry A, Stefan MI, Snoep JL, Hucka M, Le Novère N, Laibe C (2010) BioModels Database: An enhanced, curated and annotated resource for published quantitative kinetic models. BMC Syst Biol., 4:92.
species: metaid_0000042
parameter: metaid_0000023
parameter: metaid_0000015
reaction: metaid_0000053
volume units: metaid_0000004
parameter: metaid_0000059
parameter: metaid_0000003
units def: metaid_0000054
parameter: metaid_0000018
species: metaid_0000036
parameter: metaid_0000010
units def: metaid_0000057
compartment: metaid_0000032
area units: metaid_0000005
parameter: metaid_0000031
parameter: metaid_0000017
type: SBMLModel
parameter: metaid_0000022
parameter: metaid_0000004
reaction: metaid_0000051
parameter: metaid_0000005
reaction: metaid_0000045
parameter: metaid_0000014
species: metaid_0000043
time units: metaid_0000057
reaction: metaid_0000052
substance units: metaid_0000054
has part: GO:0008607
name: Rozi2003_GlycogenPhosphorylase_Activation
parameter: metaid_0000013
length unit: length
parameter: metaid_0000026
parameter: metaid_0000027
has part: hsa04020
parameter: metaid_0000030
reaction: metaid_0000044
compartment: metaid_0000034
parameter: metaid_0000016
occurs in: http://identifiers.org/taxonomy/131567
units def: metaid_0000056
is version of: GO:0019722
reaction: metaid_0000050
parameter: metaid_0000028
parameter: metaid_0000029
parameter: metaid_0000020
is described by: http://identifiers.org/pubmed/14556891
parameter: metaid_0000021
parameter: metaid_0000008
reaction: metaid_0000048
reaction: metaid_0000049

178734
stoichiometry: 1.0
species: metaid_0000043
type: SpeciesReference

metaid_0000011
constant: true
units: metaid_0000055
value: 0.2
type: Parameter