165769
stoichiometry: 1.0
species: metaid_0000035
type: SpeciesReference

metaid_0000029
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: metaid_0000025
name: MisP
type: Species

metaid_0000055
kinetic law: 165697
product: 165685
reactant: 165673
is version of: GO:0043624
fast: false
reversible: false
name: deDimerisation
type: Reaction

165685
stoichiometry: 2.0
species: metaid_0000028
type: SpeciesReference

metaid_0000009
constant: true
value: 6.0E-7
name: k6
type: Parameter

metaid_0000060
kinetic law: 165925
product: 165913
reactant: 165901
fast: false
reversible: false
name: countTime
type: Reaction

165085
stoichiometry: 1.0
species: metaid_0000033
type: SpeciesReference

165865
stoichiometry: 1.0
species: metaid_0000039
type: SpeciesReference

metaid_0000021
constant: true
value: 12.0
name: k18
type: Parameter

165445
stoichiometry: 1.0
species: metaid_0000026
type: SpeciesReference

metaid_0000016
constant: true
value: 0.5
name: k13
type: Parameter

metaid_0000040
constant: false
boundary condition: false
name: ADP
initial concentration: NaN
type: Species
has only substance units: true
initial amount: 1000.0
is: C00008
in compartment: metaid_0000025
is: CHEBI:16761

metaid_0000041
constant: false
boundary condition: true
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: metaid_0000025
name: source
type: Species

165709
stoichiometry: 1.0
species: metaid_0000031
type: SpeciesReference

metaid_0000035
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 1.0
in compartment: metaid_0000025
name: HSE
type: Species

metaid_0000049
kinetic law: 165433
product: 165421
reactant: 165409
reactant: 165397
is version of: GO:0043623
fast: false
reversible: false
type: Reaction

165265
stoichiometry: 1.0
species: metaid_0000026
type: SpeciesReference

165109
stoichiometry: 1.0
species: metaid_0000029
type: SpeciesReference

metaid_0000056
kinetic law: 165745
product: 165733
reactant: 165721
reactant: 165709
is version of: GO:0043623
fast: false
reversible: false
name: HSETriHBinding
type: Reaction

166045
stoichiometry: 1.0
species: metaid_0000038
type: SpeciesReference

165721
stoichiometry: 1.0
species: metaid_0000035
type: SpeciesReference

metaid_0000022
constant: true
value: 0.02
name: k19
type: Parameter

metaid_0000015
constant: true
value: 0.5
name: k12
type: Parameter

metaid_0000042
kinetic law: 165073
product: 165061
reactant: 165048
is version of: GO:0009059
fast: false
reversible: false
name: proteinSynthesis
type: Reaction

165637
stoichiometry: 1.0
species: metaid_0000028
type: SpeciesReference

metaid_0000036
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: metaid_0000025
name: HSETriH
type: Species

165145
stoichiometry: 1.0
species: metaid_0000029
type: SpeciesReference

165937
stoichiometry: 1.0
species: metaid_0000040
type: SpeciesReference

165853
stoichiometry: 1.0
species: metaid_0000026
type: SpeciesReference

165097
stoichiometry: 1.0
species: metaid_0000038
type: SpeciesReference

165673
stoichiometry: 1.0
species: metaid_0000032
type: SpeciesReference

metaid_0000014
constant: true
value: 100.0
name: k11
type: Parameter

metaid_0000043
kinetic law: 165133
reversible: false
reactant: 165097
type: Reaction
has version: GO:0022417
product: 165121
reactant: 165085
fast: false
name: misfolding
product: 165109

165577
stoichiometry: 1.0
species: metaid_0000028
type: SpeciesReference

metaid_0000023
constant: true
value: 0.1
name: k20
type: Parameter

165373
stoichiometry: 1.0
species: metaid_0000034
type: SpeciesReference

metaid_0000033
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 6000000.0
in compartment: metaid_0000025
name: NatP
type: Species

metaid_0000004
constant: true
value: 10.0
name: k1
type: Parameter

165805
stoichiometry: 1.0
species: metaid_0000036
type: SpeciesReference

165985
stoichiometry: 1.0
species: metaid_0000040
type: SpeciesReference

metaid_0000053
kinetic law: 165613
product: 165601
reactant: 165589
reactant: 165577
is version of: GO:0043623
fast: false
reversible: false
name: trimerisation
type: Reaction

165601
stoichiometry: 1.0
species: metaid_0000031
type: SpeciesReference

165313
stoichiometry: 1.0
species: metaid_0000029
type: SpeciesReference

165733
stoichiometry: 1.0
species: metaid_0000036
type: SpeciesReference

BIOMD0000000091
species: metaid_0000032
species: metaid_0000041
parameter: metaid_0000006
parameter: metaid_0000024
reaction: metaid_0000050
reaction: metaid_0000062
species: metaid_0000026
is: MODEL2223638385
time units: metaid_0000039
area units: metaid_0000005
reaction: metaid_0000042
reaction: metaid_0000049
parameter: metaid_0000016
species: metaid_0000040
reaction: metaid_0000060
curated: true
length unit: length
reaction: metaid_0000047
reaction: metaid_0000059
notes: This is model is according to the paper Modelling the actions of chaperones and their role in ageing. This is a stochastic model coded in SBML. Figure 2A and Figure2B has been reproduced by Gillespie2 and Copasi4.0.19(development). To the extent possible under law, all copyright and related or neighbouring rights to this encoded model have been dedicated to the public domain worldwide. Please refer to CC0 Public Domain Dedication for more information. In summary, you are entitled to use this encoded model in absolutely any manner you deem suitable, verbatim, or with modification, alone or embedded it in a larger context, redistribute it, commercially or not, in a restricted way or not. To cite BioModels Database, please use: Li C, Donizelli M, Rodriguez N, Dharuri H, Endler L, Chelliah V, Li L, He E, Henry A, Stefan MI, Snoep JL, Hucka M, Le Novère N, Laibe C (2010) BioModels Database: An enhanced, curated and annotated resource for published quantitative kinetic models. BMC Syst Biol., 4:92.
type: SBMLModel
parameter: metaid_0000014
is described by: http://identifiers.org/pubmed/15610770
parameter: metaid_0000021
reaction: metaid_0000044
reaction: metaid_0000057
name: Proctor2005 - Actions of chaperones and their role in ageing
reaction: metaid_0000051
occurs in: http://identifiers.org/taxonomy/131567
species: metaid_0000033
reaction: metaid_0000064
species: metaid_0000028
species: metaid_0000037
species: metaid_0000027
parameter: metaid_0000010
parameter: metaid_0000005
created:
  W3 CDTF: Mon Feb 26 13:30:45 GMT 2007
parameter: metaid_0000023
parameter: metaid_0000018
is version of: GO:0051085
parameter: metaid_0000019
reaction: metaid_0000048
volume units: metaid_0000004
parameter: metaid_0000015
reaction: metaid_0000054
compartment: metaid_0000025
creator:
  ORG:
    orgname: University of Newcastle
  n:
    given: Carole
    family: Proctor
units def: metaid_0000003
parameter: metaid_0000012
reaction: metaid_0000046
parameter: metaid_0000013
modified:
  W3 CDTF: Mon Jul 22 14:20:25 BST 2013
parameter: metaid_0000020
substance units: metaid_0000003
reaction: metaid_0000056
species: metaid_0000035
species: metaid_0000034
species: metaid_0000039
species: metaid_0000038
is version of: GO:0009408
parameter: metaid_0000007
reaction: metaid_0000063
parameter: metaid_0000008
species: metaid_0000031
species: metaid_0000030
parameter: metaid_0000004
reaction: metaid_0000043
parameter: metaid_0000022
parameter: metaid_0000009
parameter: metaid_0000017
reaction: metaid_0000061
reaction: metaid_0000053
species: metaid_0000029
parameter: metaid_0000011
reaction: metaid_0000045
reaction: metaid_0000058
species: metaid_0000036
reaction: metaid_0000052
reaction: metaid_0000055
is version of: GO:0007569

metaid_0000044
kinetic law: 165181
product: 165169
reactant: 165157
reactant: 165145
is version of: GO:0051879
fast: false
reversible: false
name: Hsp90MisPBinding
type: Reaction

metaid_0000013
constant: true
value: 0.01
name: k10
type: Parameter

165649
stoichiometry: 1.0
species: metaid_0000032
type: SpeciesReference

165217
stoichiometry: 1.0
species: metaid_0000026
type: SpeciesReference

metaid_0000024
constant: true
value: 0.001
name: k21
type: Parameter

metaid_0000034
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: metaid_0000025
name: AggP
type: Species

165289
stoichiometry: 1.0
species: metaid_0000040
type: SpeciesReference

metaid_0000054
kinetic law: 165661
product: 165649
product: 165637
reactant: 165625
is version of: GO:0043624
fast: false
reversible: false
name: deTrimerisation
type: Reaction

165361
stoichiometry: 2.0
species: metaid_0000029
type: SpeciesReference

metaid_0000045
kinetic law: 165229
product: 165217
product: 165205
reactant: 165193
is version of: GO:0043624
fast: false
reversible: false
name: unsuccessfulRefolding
type: Reaction

metaid_0000039
boundary condition: false
is: C00002
type: Species
initial amount: 10000.0
name: ATP
has only substance units: true
in compartment: metaid_0000025
constant: false
is: CHEBI:15422
initial concentration: NaN

165973
stoichiometry: 1.0
species: metaid_0000039
type: SpeciesReference

165817
stoichiometry: 1.0
species: metaid_0000036
type: SpeciesReference

metaid_0000064
kinetic law: 166057
reactant: 166045
is version of: GO:0016209
fast: false
reversible: false
name: radicalScavenging
type: Reaction

metaid_0000031
constant: false
initial amount: 0.0
name: TriH
is version of: GO:0043234
type: Species
has only substance units: true
has part: IPR000232
in compartment: metaid_0000025
initial concentration: NaN
boundary condition: false

metaid_0000025
is version of: GO:0005623
constant: true
size: 1.0
spatial dimensions: 3.0
type: Compartment

metaid_0000059
name: Hsp90Degradation
is version of: GO:0044257
reactant: 165865
is version of: GO:0016887
type: Reaction
kinetic law: 165889
reversible: false
product: 165877
reactant: 165853
fast: false

165409
stoichiometry: 1.0
species: metaid_0000034
type: SpeciesReference

165589
stoichiometry: 1.0
species: metaid_0000032
type: SpeciesReference

metaid_0000050
kinetic law: 165481
product: 165469
reactant: 165457
reactant: 165445
is version of: GO:0051879
fast: false
reversible: false
name: Hsp90HSF1Binding
type: Reaction

metaid_0000012
constant: true
value: 1.0
name: k9
type: Parameter

metaid_0000006
constant: true
value: 50.0
name: k3
type: Parameter

165469
stoichiometry: 1.0
species: metaid_0000027
type: SpeciesReference

165157
stoichiometry: 1.0
species: metaid_0000026
type: SpeciesReference

165949
stoichiometry: 1.0
species: metaid_0000039
type: SpeciesReference

166009
stoichiometry: 0.0
species: metaid_0000041
type: SpeciesReference

metaid_0000046
is version of: GO:0042026
reversible: false
type: Reaction
reactant: 165253
reactant: 165241
is version of: GO:0016887
product: 165277
name: refolding
kinetic law: 165301
product: 165289
fast: false
product: 165265

165517
stoichiometry: 1.0
species: metaid_0000028
type: SpeciesReference

metaid_0000063
kinetic law: 166033
product: 166021
reactant: 166009
is part of: GO:0006800
fast: false
reversible: false
name: radicalFormation
type: Reaction

165277
stoichiometry: 1.0
species: metaid_0000033
type: SpeciesReference

165541
stoichiometry: 2.0
species: metaid_0000028
type: SpeciesReference

165493
stoichiometry: 1.0
species: metaid_0000027
type: SpeciesReference

metaid_0000032
name: DiH
type: Species
initial concentration: NaN
in compartment: metaid_0000025
boundary condition: false
is version of: GO:0043234
has only substance units: true
has part: IPR000232
constant: false
initial amount: 0.0

metaid_0000011
constant: true
value: 500.0
name: k8
type: Parameter

metaid_0000026
is: IPR001404
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 300000.0
in compartment: metaid_0000025
name: Hsp90
type: Species

165241
stoichiometry: 1.0
species: metaid_0000030
type: SpeciesReference

metaid_0000005
constant: true
value: 2.0E-5
name: k2
type: Parameter

metaid_0000019
constant: true
value: 1000.0
name: k16
type: Parameter

166021
stoichiometry: 1.0
species: metaid_0000038
type: SpeciesReference

165901
stoichiometry: 0.0
species: metaid_0000041
type: SpeciesReference

165061
stoichiometry: 1.0
species: metaid_0000033
type: SpeciesReference

165421
stoichiometry: 2.0
species: metaid_0000034
type: SpeciesReference

165325
stoichiometry: 1.0
species: metaid_0000039
type: SpeciesReference

metaid_0000062
kinetic law: 165997
product: 165985
reactant: 165973
is version of: GO:0016887
fast: false
reversible: false
name: ATPconsumption
type: Reaction

metaid_0000037
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: metaid_0000025
name: X
type: Species

metaid_0000047
kinetic law: 165349
product: 165337
reactant: 165325
reactant: 165313
is version of: GO:0016887
fast: false
reversible: false
name: proteinDegradation
type: Reaction

metaid_0000027
is version of: GO:0043234
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 5900.0
in compartment: metaid_0000025
name: HCom
type: Species

metaid_0000057
kinetic law: 165793
product: 165781
product: 165769
reactant: 165757
is version of: GO:0043624
fast: false
reversible: false
name: HSETriHRelease
type: Reaction

165829
stoichiometry: 1.0
species: metaid_0000026
type: SpeciesReference

165205
stoichiometry: 1.0
species: metaid_0000029
type: SpeciesReference

165121
stoichiometry: 1.0
species: metaid_0000038
type: SpeciesReference

metaid_0000052
kinetic law: 165565
product: 165553
reactant: 165541
is version of: GO:0043623
fast: false
reversible: false
name: dimerisation
type: Reaction

165169
stoichiometry: 1.0
species: metaid_0000030
type: SpeciesReference

165457
stoichiometry: 1.0
species: metaid_0000028
type: SpeciesReference

165193
stoichiometry: 1.0
species: metaid_0000030
type: SpeciesReference

165757
stoichiometry: 1.0
species: metaid_0000036
type: SpeciesReference

metaid_0000010
constant: true
value: 1.0E-7
name: k7
type: Parameter

165781
stoichiometry: 1.0
species: metaid_0000031
type: SpeciesReference

metaid_0000018
constant: true
value: 0.08
name: k15
type: Parameter

metaid_0000008
constant: true
value: 4.0E-6
name: k5
type: Parameter

metaid_0000048
kinetic law: 165385
product: 165373
reactant: 165361
is version of: GO:0043623
fast: false
reversible: false
type: Reaction

165553
stoichiometry: 1.0
species: metaid_0000032
type: SpeciesReference

metaid_0000020
constant: true
value: 8.02E-9
name: k17
type: Parameter

165253
stoichiometry: 1.0
species: metaid_0000039
type: SpeciesReference

metaid_0000061
kinetic law: 165961
product: 165949
reactant: 165937
is version of: GO:0006757
fast: false
reversible: false
name: ATPformation
type: Reaction

metaid_0000038
is version of: CHEBI:26523
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 100.0
in compartment: metaid_0000025
name: ROS
type: Species

165036
exponent: 1.0
scale: 0
multipler: 1.0
kind: ITEM
type: SBMLUnit

metaid_0000028
is version of: IPR000232
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 100.0
in compartment: metaid_0000025
name: HSF1
type: Species

165397
stoichiometry: 1.0
species: metaid_0000029
type: SpeciesReference

metaid_0000058
kinetic law: 165841
product: 165829
product: 165817
reactant: 165805
is version of: GO:0006351
fast: false
reversible: false
name: Hsp90Transcription
type: Reaction

165505
stoichiometry: 1.0
species: metaid_0000026
type: SpeciesReference

metaid_0000051
kinetic law: 165529
product: 165517
product: 165505
reactant: 165493
is version of: GO:0043624
fast: false
reversible: false
name: Hsp90HSF1Release
type: Reaction

metaid_0000030
is version of: GO:0043234
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: metaid_0000025
name: MCom
type: Species

165625
stoichiometry: 1.0
species: metaid_0000031
type: SpeciesReference

165048
stoichiometry: 0.0
species: metaid_0000041
type: SpeciesReference

165913
stoichiometry: 1.0
species: metaid_0000037
type: SpeciesReference

165877
stoichiometry: 1.0
species: metaid_0000040
type: SpeciesReference

metaid_0000007
constant: true
value: 1.0E-5
name: k4
type: Parameter

165337
stoichiometry: 1.0
species: metaid_0000040
type: SpeciesReference

metaid_0000017
constant: true
value: 0.05
name: k14
type: Parameter

given: Enuo
family: He

orgname: BNMC