102974
units: dimensionless
value: 1.7299
name: ratio
type: LocalParameter

121297
kinetic law: 097187
product: 097175
reactant: 097163
reactant: 097151
is: GO:0005515
fast: false
reversible: true
name: B1-1
type: Reaction

100655
units: metaid_0000224
value: 3.94
name: Vmax
type: LocalParameter

096448
exponent: 3.0
scale: 0
multipler: 1.0
kind: LITRE
type: SBMLUnit

099007
units: metaid_0000224
value: 1.0
name: kf
type: LocalParameter

121620
kinetic law: 102517
product: 102505
reactant: 102493
is: GO:0006470
is: GO:0017020
fast: false
reversible: false
name: F1-1
type: Reaction

103947
stoichiometry: 1.0
species: 120932
type: SpeciesReference

121646
product: 103022
reactant: 102998
type: Reaction
is: GO:0032027
reversible: true
kinetic law: 103034
is part of: R03150
reactant: 103010
name: F2-5.3.1
fast: false

121247
is version of: O14974
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.4941
initial amount: NaN
in compartment: 120775
name: MYPT1_PPase
type: Species

120781
is: GO:0005783
constant: true
size: 0.1
spatial dimensions: 3.0
name: ER
type: Compartment

121308
kinetic law: 097415
product: 097403
reactant: 097391
reactant: 097379
is: GO:0035024
fast: false
reversible: true
name: B2-3.1
type: Reaction

121207
name: PKC.Ca_super_2_plus__endsuper_.DAG
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boundary condition: false
type: Species
initial concentration: 0.0
has only substance units: false
has part: CHEBI:29108
has part: C00165
in compartment: 120775
has part: CHEBI:18035
initial amount: NaN
has part: P17252
constant: false

101967
units: metaid_0000224
value: 1.95
name: Vmax
type: LocalParameter

097439
units: dimensionless
value: 13.246
name: ratio
type: LocalParameter

099790
stoichiometry: 1.0
species: 120947
type: SpeciesReference

121434
kinetic law: 099271
product: 099259
reactant: 099247
reactant: 099235
is: GO:0005509
fast: false
reversible: true
name: D1-5
type: Reaction

096594
stoichiometry: 1.0
species: 121040
type: SpeciesReference

103526
stoichiometry: 1.0
species: 120941
type: SpeciesReference

121227
has part: P29992
has part: CHEBI:29108
type: Species
in compartment: 120775
boundary condition: false
constant: false
has part: C00076
has part: CHEBI:15996
has part: C00044
initial amount: NaN
name: PLC_beta_.G_sub_q_endsub_.GTP.Ca.PIP2
initial concentration: 0.0
has only substance units: false
has part: Q9NQ66

103478
units: dimensionless
value: 1.7299
name: ratio
type: LocalParameter

103082
stoichiometry: 1.0
species: 121008
type: SpeciesReference

099645
units: metaid_0000224
value: 50.0
name: kb
type: LocalParameter

097691
units: metaid_0000224
value: 0.0117
name: kf
type: LocalParameter

097343
units: metaid_0000227
value: 2.0
name: Km
type: LocalParameter

120899
type: Species
constant: false
in compartment: 120775
has part: P61586
boundary condition: false
has part: CHEBI:17552
has only substance units: false
initial concentration: 0.09
name: Rho.GDP
has part: C00035
initial amount: NaN

121265
is: GO:0031684
product: 096582
is: GO:0015057
fast: false
product: 096594
product: 096618
product: 096606
reactant: 096558
reactant: 096570
is: GO:0003924
kinetic law: 096630
name: A1-2
reversible: false
type: Reaction

097777
stoichiometry: 1.0
species: 120910
type: SpeciesReference

103790
units: metaid_0000224
value: 3.67
name: Vmax
type: LocalParameter

metaid_0000223
unit: 096375
unit: 096363
unit: 096349
name: per_uM_per_sec
type: SBMLUnitsDef

096522
units: metaid_0000227
value: 5.0
name: Km
type: LocalParameter

101343
stoichiometry: 1.0
species: 121119
type: SpeciesReference

098815
units: metaid_0000224
value: 2.5
name: kf
type: LocalParameter

097813
units: metaid_0000224
value: 0.5
name: kb
type: LocalParameter

103394
units: dimensionless
value: 1.7299
name: ratio
type: LocalParameter

121506
reactant: 100438
is: http://identifiers.org/ec-code/2.7.11.13
reversible: true
is: GO:0004698
reactant: 100450
is: GO:0005080
fast: false
kinetic law: 100474
name: E2-1.1.2
product: 100462
type: Reaction

102292
units: metaid_0000224
value: 1.95
name: Vmax
type: LocalParameter

098549
units: metaid_0000227
value: 5.0
name: Km
type: LocalParameter

102149
stoichiometry: 1.0
species: 121127
type: SpeciesReference

096845
stoichiometry: 1.0
species: 121045
type: SpeciesReference

098694
stoichiometry: 1.0
species: 121202
type: SpeciesReference

101751
stoichiometry: 1.0
species: 120910
type: SpeciesReference

099922
stoichiometry: 1.0
species: 121054
type: SpeciesReference

121382
fast: false
type: Reaction
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is: GO:0005546
reactant: 098513
kinetic law: 098537
is part of: GO:0004435
reactant: 098501
name: C2-2.1
is part of: R03435
reversible: true

102674
units: metaid_0000227
value: 148.08
name: Km
type: LocalParameter

102914
stoichiometry: 1.0
species: 121008
type: SpeciesReference

102481
units: metaid_0000224
value: 9.317
name: Vmax
type: LocalParameter

102818
units: metaid_0000224
value: 3.67
name: Vmax
type: LocalParameter

metaid_0000225
unit: 096424
unit: 096412
unit: 096400
name: per_uM2_per_sec
type: SBMLUnitsDef

103923
stoichiometry: 1.0
species: 121181
type: SpeciesReference

121562
reversible: false
type: Reaction
name: F2-3.2
is: http://identifiers.org/ec-code/2.7.11.1
is: GO:0004674
product: 101511
product: 101499
fast: false
reactant: 101487
kinetic law: 101523

099439
units: metaid_0000224
value: 0.01
name: kb
type: LocalParameter

098730
stoichiometry: 1.0
species: 120876
type: SpeciesReference

097655
stoichiometry: 1.0
species: 121077
type: SpeciesReference

121543
kinetic law: 101151
product: 101139
reactant: 101127
reactant: 101115
is: GO:0032027
fast: false
reversible: true
name: F2-2.1
type: Reaction

102998
stoichiometry: 1.0
species: 121008
type: SpeciesReference

121437
kinetic law: 099343
product: 099331
reactant: 099319
reactant: 099307
is: GO:0019901
fast: false
reversible: true
name: D1-10
type: Reaction

100631
stoichiometry: 1.0
species: 121021
type: SpeciesReference

121243
is version of: O14974
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.7
initial amount: NaN
in compartment: 120775
name: MYPT1_PPase
type: Species

121458
is: GO:0008426
reactant: 099669
product: 099681
reversible: true
is: GO:0019992
type: Reaction
is: GO:0005080
kinetic law: 099693
fast: false
reactant: 099657
name: E1-3

099535
stoichiometry: 1.0
species: 120928
type: SpeciesReference

metaid_0000224
unit: 096388
name: per_sec
type: SBMLUnitsDef

102396
stoichiometry: 1.0
species: 121247
type: SpeciesReference

121294
kinetic law: 097127
product: 097115
reactant: 097103
reactant: 097091
is: GO:0031684
fast: false
reversible: false
name: A1-9
type: Reaction

121181
type: Species
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has part: P05976
has only substance units: false
initial amount: NaN
name: MLCK.Ca_super_2_plus__endsuper_.CaM.MLC
constant: false
has part: C00391
has part: Q9H1R3
has part: CHEBI:29108
has part: P62158
boundary condition: false
initial concentration: 0.0
in compartment: 120775

120817
name: RGS
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initial concentration: 0.2
is: IPR000342
initial amount: NaN
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in compartment: 120775
has only substance units: false
boundary condition: false
is version of: O94810

121119
has part: CHEBI:15996
initial amount: NaN
has part: P05976
has part: Q13464
has part: C00044
has only substance units: false
has part: P61586
type: Species
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in compartment: 120775
boundary condition: false
constant: false
name: Rho.GTP.Rho-kinase.MLC

102357
units: metaid_0000224
value: 9.317
name: Vmax
type: LocalParameter

121583
type: Reaction
name: F2-13.2
product: 101859
reactant: 101835
reversible: false
is: http://identifiers.org/ec-code/2.7.11.1
is: GO:0004674
product: 101847
is: GO:0017020
kinetic law: 101871
fast: false

098839
stoichiometry: 3.0
species: 120883
type: SpeciesReference

metaid_0000227
unit: 096337
unit: 096325
name: microMolar
type: SBMLUnitsDef

103322
units: metaid_0000224
value: 3.67
name: Vmax
type: LocalParameter

121202
constant: false
name: PLC_beta_.G_sub_q_endsub__alpha_.GTP.Ca_super_2_plus__endsuper_
boundary condition: false
type: Species
initial amount: NaN
has part: C00044
has only substance units: false
has part: Q9NQ66
in compartment: 120775
initial concentration: 0.0
has part: CHEBI:15996
has part: C00076
has part: P29992
has part: CHEBI:29108

098791
stoichiometry: 1.0
species: 120825
type: SpeciesReference

101367
units: metaid_0000227
value: 2.47
name: Km
type: LocalParameter

098585
stoichiometry: 1.0
species: 121232
type: SpeciesReference

101259
stoichiometry: 1.0
species: 121016
type: SpeciesReference

101451
units: metaid_0000227
value: 2.47
name: Km
type: LocalParameter

098284
stoichiometry: 1.0
species: 121049
type: SpeciesReference

121580
is: GO:0019901
is: GO:0017049
type: Reaction
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is: GO:0017020
product: 101775
name: F2-13.1
reversible: true
reactant: 101763
kinetic law: 101787
fast: false

097367
units: metaid_0000224
value: 0.04
name: Vmax
type: LocalParameter

101415
stoichiometry: 1.0
species: 121127
type: SpeciesReference

097028
stoichiometry: 1.0
species: 120841
type: SpeciesReference

121503
is: GO:0005080
reversible: true
product: 100378
reactant: 100354
type: Reaction
name: E2-1.1.3
kinetic law: 100390
is: GO:0004697
reactant: 100366
fast: false
is: http://identifiers.org/ec-code/2.7.11.13

metaid_0000226
unit: 096313
name: micromoles
type: SBMLUnitsDef

100571
units: metaid_0000227
value: 0.0014
name: Km
type: LocalParameter

097067
units: dimensionless
value: 23.51
name: ratio
type: LocalParameter

121492
kinetic law: 100246
product: 100234
reactant: 100222
is: GO:0030163
fast: false
reversible: false
name: E1-2
type: Reaction

102305
stoichiometry: 1.0
species: 121136
type: SpeciesReference

103190
stoichiometry: 1.0
species: 121178
type: SpeciesReference

102698
units: metaid_0000224
value: 3.67
name: Vmax
type: LocalParameter

100210
units: metaid_0000224
value: 4.63E-5
name: kf
type: LocalParameter

097001
stoichiometry: 1.0
species: 120817
type: SpeciesReference

098670
stoichiometry: 1.0
species: 120876
type: SpeciesReference

100378
stoichiometry: 1.0
species: 120984
type: SpeciesReference

120896
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 120775
name: PC
type: Species

121520
type: Reaction
product: 100739
is: GO:0004699
kinetic law: 100763
product: 100751
reversible: false
reactant: 100727
is: http://identifiers.org/ec-code/2.7.11.13
fast: false
name: E2-1.2.1

099946
stoichiometry: 1.0
species: 121105
type: SpeciesReference

103046
units: metaid_0000227
value: 10.019
name: Km
type: LocalParameter

099283
units: metaid_0000223
value: 10.0
name: kf
type: LocalParameter

100102
units: metaid_0000224
value: 1.0
name: kf
type: LocalParameter

121414
fast: false
type: Reaction
is: GO:0005509
kinetic law: 099055
product: 099043
name: D1-3
reversible: true
is: GO:0005516
reactant: 099031
reactant: 099019

099511
units: metaid_0000224
value: 0.45
name: kb
type: LocalParameter

103646
stoichiometry: 1.0
species: 120938
type: SpeciesReference

098887
units: metaid_0000224
value: 10.0
name: kb
type: LocalParameter

103983
stoichiometry: 1.0
species: 121190
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098018
stoichiometry: 1.0
species: 120812
type: SpeciesReference

121453
kinetic law: 099621
product: 099609
reactant: 099596
is: GO:0007205
fast: false
reversible: true
name: E1-1
type: Reaction

121566
fast: false
kinetic law: 101583
reversible: false
product: 101559
type: Reaction
product: 101571
name: F2-4.2
is: http://identifiers.org/ec-code/2.7.11.1
is: GO:0004674
reactant: 101547

100523
stoichiometry: 1.0
species: 120950
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097475
stoichiometry: 1.0
species: 120889
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121115
initial amount: NaN
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boundary condition: false
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name: Rho.GTP.Rho-kinase.MLC
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100426
units: metaid_0000224
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name: Vmax
type: LocalParameter

103706
stoichiometry: 1.0
species: 120938
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099139
units: metaid_0000223
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name: kf
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103430
stoichiometry: 1.0
species: 120941
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099572
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type: LocalParameter

103262
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species: 120935
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099391
stoichiometry: 1.0
species: 120928
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097583
stoichiometry: 1.0
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096655
stoichiometry: 1.0
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121166
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099211
units: metaid_0000223
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121186
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has only substance units: false
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initial amount: NaN
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100595
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name: Vmax
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101163
units: metaid_0000227
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name: Km
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097607
stoichiometry: 1.0
species: 120817
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101883
units: metaid_0000224
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name: Vmax
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098223
stoichiometry: 1.0
species: 121101
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097307
stoichiometry: 1.0
species: 120899
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101799
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096313
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scale: -6
multipler: 1.0
kind: MOLE
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121133
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has only substance units: false
constant: false
type: Species
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boundary condition: false

120910
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type: Species
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name: Rho.GTP.Rho-kinase
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098260
units: metaid_0000223
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name: kf
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121411
kinetic law: 098995
product: 098983
product: 098971
reactant: 098959
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reversible: false
name: D1-2
type: Reaction

104091
units: metaid_0000223
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type: LocalParameter

101739
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name: Vmax
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097897
stoichiometry: 1.0
species: 121073
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097945
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102541
stoichiometry: 1.0
species: 121008
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098561
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100993
stoichiometry: 1.0
species: 120993
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104031
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name: g
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101475
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name: Vmax
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097271
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name: Km
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121160
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boundary condition: false
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has only substance units: false
has part: CHEBI:29108
name: MLCK.3Ca_super_2_plus__endsuper_.CaM.MLC
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103622
stoichiometry: 1.0
species: 121160
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121021
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boundary condition: false
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099669
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100126
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species: 120961
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121110
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type: Species
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initial amount: NaN
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101943
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096794
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121430
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reversible: true
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100402
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099850
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121139
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121036
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101607
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121450
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reversible: true
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101187
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121136
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boundary condition: false
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121588
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102650
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species: 121145
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BIOMD0000000088
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curated: true
species: 120955
species: 121021
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reaction: 121411
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substance units: metaid_0000226
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species: 121237
reaction: 121434
notes: The model reproduces Fig 2B, D, F, and 2H. The dynamics correspond to a stimulus of 1 U/ml of thrombin which is equal to 0.01 uM. Phosphorylated MLC is the sum of pMLC (s359) and ppMLC (s360). A slight discrepancy in peak values of species between the figure in the paper and simulation result might be due to different initial conditions in the two sets. The model was successfully tested on MathSBML. It is possible to simulate the model on other software that do not support "Events" at this time by removing the "listOfEvents" and substituting a value of 0.01 for thrombin (s2). This does not change the model very much. With the latter format, the model was also successfully tested on Copasi. To the extent possible under law, all copyright and related or neighbouring rights to this encoded model have been dedicated to the public domain worldwide. Please refer to CC0 Public Domain Dedication for more information. In summary, you are entitled to use this encoded model in absolutely any manner you deem suitable, verbatim, or with modification, alone or embedded it in a larger context, redistribute it, commercially or not, in a restricted way or not. To cite BioModels Database, please use: Li C, Donizelli M, Rodriguez N, Dharuri H, Endler L, Chelliah V, Li L, He E, Henry A, Stefan MI, Snoep JL, Hucka M, Le Novère N, Laibe C (2010) BioModels Database: An enhanced, curated and annotated resource for published quantitative kinetic models. BMC Syst Biol., 4:92.
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units: metaid_0000224
value: 8.66
name: Vmax
type: LocalParameter

102878
units: metaid_0000227
value: 10.019
name: Km
type: LocalParameter

099499
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type: LocalParameter

121623
reactant: 102541
reversible: true
name: F2-7.1
kinetic law: 102577
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product: 102565
is: GO:0019901
type: Reaction
reactant: 102553

120862
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initial concentration: 0.0
name: 3IP3.IP3R
boundary condition: false
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has part: CHEBI:16595
initial amount: NaN
type: Species
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098959
stoichiometry: 1.0
species: 121105
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102938
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species: 121175
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099043
stoichiometry: 1.0
species: 120913
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101595
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value: 8.66
name: Vmax
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101211
stoichiometry: 1.0
species: 121127
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102162
stoichiometry: 1.0
species: 121243
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101847
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species: 120910
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121604
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reversible: false
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kinetic law: 102279
type: Reaction
product: 102266
reactant: 102240
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121461
kinetic law: 099754
product: 099742
reactant: 099730
is: GO:0007205
fast: false
reversible: true
name: E1-5
type: Reaction

120841
constant: false
name: RGS
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initial amount: NaN
in compartment: 120775
type: Species
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is: IPR000342
initial concentration: 0.0
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103887
stoichiometry: 1.0
species: 120932
type: SpeciesReference

103574
stoichiometry: 1.0
species: 121127
type: SpeciesReference

099681
stoichiometry: 1.0
species: 120955
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097753
stoichiometry: 1.0
species: 120869
type: SpeciesReference

121336
is: GO:0035025
reactant: 097753
reversible: true
reactant: 097765
name: B1-4
is: EBI-876651
type: Reaction
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product: 097777
kinetic law: 097789

121374
kinetic law: 098392
product: 098380
product: 098368
reactant: 098356
is: GO:0003924
fast: false
reversible: false
name: C1-5
type: Reaction

121643
reactant: 102914
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type: Reaction
reactant: 102926
kinetic law: 102950
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product: 102938
is: GO:0032027
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096897
stoichiometry: 1.0
species: 121077
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103502
stoichiometry: 1.0
species: 121157
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096570
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102266
stoichiometry: 1.0
species: 121247
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121601
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product: 102175
type: Reaction
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reactant: 102162
kinetic law: 102188
is: GO:0017018
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reversible: true
is: GO:0032027

103226
units: dimensionless
value: 1.7299
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121274
type: Reaction
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is: GO:0015057
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reactant: 096716
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kinetic law: 096742
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121684
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fast: false
product: 103646
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kinetic law: 103658
product: 103634
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type: Reaction
is: GO:0004687
reactant: 103622

121322
kinetic law: 097559
product: 097547
product: 097535
reactant: 097523
is: GO:0035024
fast: false
reversible: false
name: B2-3.2
type: Reaction

098513
stoichiometry: 1.0
species: 120893
type: SpeciesReference

121062
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has only substance units: false
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has part: P62873
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has part: P63211
in compartment: 120775
type: Species
constant: false
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100957
units: metaid_0000223
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121488
kinetic law: 100198
product: 100186
reactant: 100174
is: GO:0030163
fast: false
reversible: false
name: E1-6
type: Reaction

100342
units: metaid_0000224
value: 4.9
name: Vmax
type: LocalParameter

098465
units: metaid_0000227
value: 19.841
name: Km
type: LocalParameter

098139
stoichiometry: 1.0
species: 121049
type: SpeciesReference

096424
exponent: -1.0
scale: 0
multipler: 1.0
kind: SECOND
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103682
stoichiometry: 1.0
species: 121166
type: SpeciesReference

097909
stoichiometry: 1.0
species: 120812
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121549
is: GO:0004674
product: 101211
reversible: false
reactant: 101199
type: Reaction
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kinetic law: 101235
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fast: false
product: 101223

097235
stoichiometry: 1.0
species: 120889
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101427
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species: 121115
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097716
stoichiometry: 1.0
species: 120899
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102052
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name: Vmax
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096474
stoichiometry: 1.0
species: 120797
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101907
stoichiometry: 1.0
species: 121247
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096716
stoichiometry: 1.0
species: 120812
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100679
stoichiometry: 1.0
species: 120958
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102370
stoichiometry: 1.0
species: 121139
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099970
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value: 30.0
name: kf
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121529
kinetic law: 100872
product: 100860
reactant: 100848
reactant: 100836
is: GO:0017020
fast: false
reversible: true
name: E1-11
type: Reaction

097861
stoichiometry: 1.0
species: 120797
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097355
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name: ratio
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103826
stoichiometry: 1.0
species: 120935
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097801
units: metaid_0000223
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name: kf
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097091
stoichiometry: 1.0
species: 121045
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121630
is: GO:0004687
type: Reaction
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product: 102734
name: F2-7.2
kinetic law: 102746
is: http://identifiers.org/ec-code/2.7.11.18
is: R03150
fast: false
product: 102722
reversible: false

103382
units: metaid_0000227
value: 10.019
name: Km
type: LocalParameter

103310
units: dimensionless
value: 1.7299
name: ratio
type: LocalParameter

103058
units: dimensionless
value: 1.7299
name: ratio
type: LocalParameter

102926
stoichiometry: 1.0
species: 120935
type: SpeciesReference

121532
kinetic law: 100945
product: 100932
reactant: 100920
reactant: 100908
is: GO:0017020
fast: false
reversible: true
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type: Reaction

121278
reactant: 096794
type: Reaction
reversible: false
is: GO:0003924
fast: false
name: A1-4
product: 096845
product: 096832
kinetic law: 096858
product: 096820
product: 096807
is: GO:0031684
reactant: 096781

102686
units: dimensionless
value: 39.349
name: ratio
type: LocalParameter

121190
boundary condition: true
initial concentration: 4000.0
is: CHEBI:29108
in compartment: 120770
constant: true
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is: C00076
type: Species
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initial amount: NaN

101763
stoichiometry: 1.0
species: 121243
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098404
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type: LocalParameter

121573
reactant: 101607
kinetic law: 101643
reversible: true
reactant: 101619
name: F2-14.1
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product: 101631
is: GO:0019901
fast: false
type: Reaction

098090
stoichiometry: 1.0
species: 121202
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121237
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constant: false
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initial amount: NaN
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initial concentration: 0.15
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type: Species
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121420
kinetic law: 099127
product: 099115
reactant: 099103
reactant: 099091
is: GO:0005509
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reversible: true
name: D1-4
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099910
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102986
units: metaid_0000224
value: 3.67
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120806
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initial concentration: 0.42
boundary condition: false
constant: false
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type: Species
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121397
kinetic law: 098754
product: 098742
reactant: 098730
is: GO:0046340
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reversible: false
name: C1-6
type: Reaction

098742
stoichiometry: 1.0
species: 120896
type: SpeciesReference

120889
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has only substance units: false
constant: false
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type: Species
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099548
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species: 120932
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103935
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species: 121127
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metaid_0000232
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trigger: 104103
use values from trigger time: true
type: Event

101955
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value: 28.795
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096729
stoichiometry: 1.0
species: 121090
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100138
stoichiometry: 1.0
species: 120964
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121657
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is: GO:0032027
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reactant: 103250
is: R03150
kinetic law: 103286
reversible: true
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103070
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name: Vmax
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121597
kinetic law: 102100
is: GO:0032027
fast: false
reactant: 102076
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reversible: true
reactant: 102064
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099633
units: metaid_0000224
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121482
kinetic law: 100090
product: 100078
reactant: 100066
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reversible: true
name: E1-8
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121219
in compartment: 120775
type: Species
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constant: false
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has part: P17252

097427
units: metaid_0000227
value: 2.83
name: Km
type: LocalParameter

103514
stoichiometry: 1.0
species: 121002
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096582
stoichiometry: 1.0
species: 121082
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098597
stoichiometry: 1.0
species: 120883
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120883
type: Species
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initial amount: NaN
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is: CHEBI:16595
boundary condition: false
in compartment: 120775
has only substance units: false
name: IP3
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101379
units: dimensionless
value: 0.4261
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101463
units: dimensionless
value: 0.4261
name: ratio
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097054
units: metaid_0000227
value: 0.05
name: Km
type: LocalParameter

098827
stoichiometry: 1.0
species: 120858
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121101
has only substance units: false
initial concentration: 0.0
constant: false
initial amount: NaN
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type: Species
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has part: P62873
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103334
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species: 121127
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121391
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kinetic law: 098706
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reversible: false

097379
stoichiometry: 1.0
species: 120872
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101403
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species: 120910
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096667
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098682
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species: 120883
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100366
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species: 120997
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121195
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is: C00076
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102902
units: metaid_0000224
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name: Vmax
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121444
kinetic law: 099487
product: 099475
reactant: 099463
reactant: 099451
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reversible: true
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100848
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species: 121021
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097981
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species: 121086
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096923
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100222
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099934
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099079
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120770
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spatial dimensions: 3.0
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097667
stoichiometry: 1.0
species: 120866
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099730
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species: 121219
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103911
units: metaid_0000224
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099019
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species: 121030
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097151
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101091
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120829
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120886
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initial amount: NaN
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103094
stoichiometry: 1.0
species: 120941
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098006
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099523
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098899
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101559
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101979
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120809
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initial concentration: 0.0
initial amount: NaN
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097015
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121510
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type: Reaction
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121400
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098163
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species: 121101
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099223
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099295
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104043
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121178
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097595
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120923
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121552
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121105
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098211
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121049
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096325
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097079
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096962
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100583
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101175
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101895
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121145
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102028
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096642
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100739
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098573
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101487
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097283
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102553
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096558
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121440
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121232
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100042
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100799
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103995
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098875
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103634
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097487
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098271
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120797
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098971
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120920
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100511
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096988
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103442
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121555
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120938
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102493
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100438
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121127
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101283
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097319
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100691
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101199
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097571
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099247
stoichiometry: 1.0
species: 121026
type: SpeciesReference

096349
exponent: -1.0
scale: -6
multipler: 1.0
kind: MOLE
type: SBMLUnit

099584
units: metaid_0000224
value: 0.5
name: kb
type: LocalParameter

103274
stoichiometry: 1.0
species: 121172
type: SpeciesReference

103166
stoichiometry: 1.0
species: 121127
type: SpeciesReference

121577
fast: false
kinetic law: 101727
is: GO:0004674
is: GO:0017020
type: Reaction
reactant: 101691
product: 101703
reversible: false
product: 101715
is: http://identifiers.org/ec-code/2.7.11.1
name: F2-14.2

121371
is part of: GO:0007202
product: 098307
name: C1-1
reactant: 098284
is: GO:0005509
reactant: 098295
type: Reaction
fast: false
kinetic law: 098320
reversible: true

100715
units: metaid_0000224
value: 3.94
name: Vmax
type: LocalParameter

121026
initial amount: NaN
name: Ca_super_2_plus__endsuper_
in compartment: 120775
boundary condition: false
has only substance units: false
is: C00076
type: Species
initial concentration: 0.0833
is: CHEBI:29108
constant: false

121175
boundary condition: false
name: MLCK.2Ca_super_2_plus__endsuper_.CaM.MLC
has part: C00076
has part: P62158
has part: P05976
initial concentration: 0.0
has part: CHEBI:29108
has only substance units: false
has part: C00391
type: Species
initial amount: NaN
has part: Q9H1R3
constant: false
in compartment: 120775

099319
stoichiometry: 1.0
species: 120928
type: SpeciesReference

100499
units: dimensionless
value: 4.0
name: ratio
type: LocalParameter

100186
stoichiometry: 1.0
species: 120967
type: SpeciesReference

100981
stoichiometry: 1.0
species: 120989
type: SpeciesReference

101139
stoichiometry: 1.0
species: 121016
type: SpeciesReference

101331
stoichiometry: 1.0
species: 121008
type: SpeciesReference

099259
stoichiometry: 1.0
species: 120920
type: SpeciesReference

097885
units: metaid_0000224
value: 15.0
name: Vmax
type: LocalParameter

096832
stoichiometry: 1.0
species: 120851
type: SpeciesReference

096534
units: dimensionless
value: 4.0
name: ratio
type: LocalParameter

102601
units: dimensionless
value: 39.349
name: ratio
type: LocalParameter

103610
units: metaid_0000224
value: 3.67
name: Vmax
type: LocalParameter

099657
stoichiometry: 1.0
species: 120947
type: SpeciesReference

103971
units: metaid_0000224
value: 3.67
name: Vmax
type: LocalParameter

102457
stoichiometry: 1.0
species: 121243
type: SpeciesReference

096781
stoichiometry: 1.0
species: 121090
type: SpeciesReference

121172
initial concentration: 0.0
in compartment: 120775
boundary condition: false
has part: CHEBI:29108
has only substance units: false
name: MLCK.2Ca_super_2_plus__endsuper_.CaM.MLC
initial amount: NaN
has part: P05976
has part: Q9H1R3
has part: C00391
type: Species
has part: C00076
has part: P62158
constant: false

098851
stoichiometry: 1.0
species: 120862
type: SpeciesReference

097403
stoichiometry: 1.0
species: 120886
type: SpeciesReference

100114
units: metaid_0000224
value: 0.1
name: kb
type: LocalParameter

103466
units: metaid_0000227
value: 10.019
name: Km
type: LocalParameter

101619
stoichiometry: 1.0
species: 121243
type: SpeciesReference

098766
units: metaid_0000224
value: 0.15
name: kf
type: LocalParameter

103106
stoichiometry: 1.0
species: 121163
type: SpeciesReference

100414
units: dimensionless
value: 4.0
name: ratio
type: LocalParameter

099862
stoichiometry: 1.0
species: 121110
type: SpeciesReference

098295
stoichiometry: 1.0
species: 121026
type: SpeciesReference

121559
reactant: 101403
is: GO:0032027
kinetic law: 101439
reversible: false
product: 101427
name: F2-4.1
is: GO:0017049
reactant: 101415
type: Reaction
fast: false

096871
units: metaid_0000223
value: 0.01
name: kf
type: LocalParameter

098368
stoichiometry: 1.0
species: 121237
type: SpeciesReference

103250
stoichiometry: 1.0
species: 121127
type: SpeciesReference

098609
stoichiometry: 1.0
species: 120876
type: SpeciesReference

102962
units: metaid_0000227
value: 10.019
name: Km
type: LocalParameter

096704
stoichiometry: 1.0
species: 121097
type: SpeciesReference

121073
initial concentration: 0.5
has part: P63211
name: G_sub_12_endsub__alpha__beta__gamma_
constant: false
has part: P62873
type: Species
has part: Q03113
has only substance units: false
in compartment: 120775
initial amount: NaN
boundary condition: false

096618
stoichiometry: 1.0
species: 120834
type: SpeciesReference

121054
initial concentration: 0.5
initial amount: NaN
boundary condition: false
has only substance units: false
is: CHEBI:29108
is: C00076
name: Ca_super_2_plus__endsuper_ trunsp
in compartment: 120775
constant: false
type: Species

098344
units: metaid_0000224
value: 1.0
name: kb
type: LocalParameter

121407
is: GO:0015085
reactant: 098899
kinetic law: 098935
is: GO:0005220
type: Reaction
modifier: 098923
name: D3-1
product: 098911
fast: false
reversible: true

101391
units: metaid_0000224
value: 8.66
name: Vmax
type: LocalParameter

097523
stoichiometry: 1.0
species: 120886
type: SpeciesReference

121703
product: 103814
kinetic law: 103838
is: http://identifiers.org/ec-code/2.7.11.18
is: GO:0004687
type: Reaction
fast: false
reversible: false
product: 103826
reactant: 103802
is: R03150
name: F2-5.2.2

098658
stoichiometry: 1.0
species: 121227
type: SpeciesReference

103694
stoichiometry: 1.0
species: 121127
type: SpeciesReference

097837
stoichiometry: 1.0
species: 120812
type: SpeciesReference

103850
units: metaid_0000224
value: 3.67
name: Vmax
type: LocalParameter

102770
stoichiometry: 1.0
species: 121145
type: SpeciesReference

120941
has only substance units: false
has version: Q9H1R3
initial amount: NaN
has version: CHEBI:29108
has version: C00076
initial concentration: 0.0
in compartment: 120775
constant: false
type: Species
has version: P62158
name: MLCK.4Ca_super_2_plus__endsuper_.CaM
has version: C00391
boundary condition: false

096755
units: metaid_0000223
value: 1.0
name: kf
type: LocalParameter

102433
stoichiometry: 1.0
species: 121142
type: SpeciesReference

102710
stoichiometry: 1.0
species: 121151
type: SpeciesReference

100751
stoichiometry: 1.0
species: 121021
type: SpeciesReference

104055
stoichiometry: 1.0
species: 121026
type: SpeciesReference

121362
name: C1-3
reactant: 098151
reversible: true
is: GO:0001965
kinetic law: 098175
product: 098163
reactant: 098139
fast: false
is part of: GO:0007200
type: Reaction

099355
units: metaid_0000223
value: 10.0
name: kf
type: LocalParameter

102124
units: dimensionless
value: 28.795
name: ratio
type: LocalParameter

098066
stoichiometry: 1.0
species: 120848
type: SpeciesReference

120858
is: Q14643
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.008333
initial amount: NaN
in compartment: 120775
name: IP3R
type: Species

121090
has part: P25116
has part: P29992
constant: false
in compartment: 120775
type: Species
name: G_sub_q_endsub__alpha__beta__gamma__thrombinR active
has only substance units: false
initial amount: NaN
initial concentration: 0.0
boundary condition: false
has part: P62873
has part: P63211

121365
kinetic law: 098247
product: 098235
reactant: 098223
reactant: 098211
is part of: GO:0007200
fast: false
reversible: true
name: C1-4
type: Reaction

121002
is version of: P05976
boundary condition: false
constant: false
initial amount: NaN
initial concentration: 0.1
in compartment: 120775
name: MLC
has only substance units: false
is: C01003
type: Species

100162
units: metaid_0000224
value: 4.63E-5
name: kf
type: LocalParameter

101703
stoichiometry: 1.0
species: 120869
type: SpeciesReference

097451
units: metaid_0000224
value: 0.993
name: Vmax
type: LocalParameter

121151
boundary condition: false
has only substance units: false
has part: P05976
in compartment: 120775
has part: Q9H1R3
initial concentration: 0.0
type: Species
constant: false
initial amount: NaN
name: MLCK.MLC

101115
stoichiometry: 1.0
species: 120869
type: SpeciesReference

121130
initial amount: NaN
has part: O14974
boundary condition: false
type: Species
has only substance units: false
name: MYPT1.Rho-kinase
constant: false
has part: Q13464
initial concentration: 0.0
in compartment: 120775

103766
stoichiometry: 1.0
species: 120935
type: SpeciesReference

120917
in compartment: 120775
type: Species
initial concentration: 0.0
has version: CHEBI:29108
name: 2Ca_super_2_plus__endsuper_.CaM
has version: C00391
constant: false
initial amount: NaN
boundary condition: false
has only substance units: false
has version: C00076
has version: P62158

103418
stoichiometry: 1.0
species: 121127
type: SpeciesReference

099187
stoichiometry: 1.0
species: 120923
type: SpeciesReference

101691
stoichiometry: 1.0
species: 121130
type: SpeciesReference

100462
stoichiometry: 1.0
species: 120979
type: SpeciesReference

103298
units: metaid_0000227
value: 10.019
name: Km
type: LocalParameter

ORG:
  orgname: University of Tokyo
n:
  given: Hiroshi
  family: Kobayashi

103142
units: dimensionless
value: 1.7299
name: ratio
type: LocalParameter

101017
units: metaid_0000224
value: 0.5
name: kf
type: LocalParameter

101655
units: metaid_0000227
value: 0.18
name: Km
type: LocalParameter

098718
units: metaid_0000224
value: 48.0
name: Vmax
type: LocalParameter

100860
stoichiometry: 1.0
species: 120989
type: SpeciesReference

120964
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 120775
name: csa39_degraded
type: Species

121058
has only substance units: false
type: Species
constant: false
name: Ca_super_2_plus__endsuper_ pump
boundary condition: false
in compartment: 120775
is: CHEBI:29108
is: C00076
initial amount: NaN
initial concentration: 0.1

100920
stoichiometry: 1.0
species: 120997
type: SpeciesReference

101307
units: metaid_0000224
value: 1.28
name: Vmax
type: LocalParameter

098307
stoichiometry: 1.0
species: 121237
type: SpeciesReference

097957
units: metaid_0000224
value: 0.006
name: kb
type: LocalParameter

102004
stoichiometry: 1.0
species: 121136
type: SpeciesReference

121097
has only substance units: false
in compartment: 120775
constant: false
name: G_sub_q_endsub__alpha__beta__gamma_
initial amount: NaN
type: Species
has part: P29992
has part: P63211
boundary condition: false
has part: P62873
initial concentration: 0.5

121030
constant: false
boundary condition: false
in compartment: 120775
name: CaM
is: C00391
is: P62158
initial amount: NaN
initial concentration: 19.65
has only substance units: false
type: Species

097391
stoichiometry: 1.0
species: 120889
type: SpeciesReference

097547
stoichiometry: 1.0
species: 120872
type: SpeciesReference

100836
stoichiometry: 1.0
species: 121243
type: SpeciesReference

100535
stoichiometry: 1.0
species: 120997
type: SpeciesReference

100775
units: metaid_0000224
value: 3.94
name: Vmax
type: LocalParameter

102638
stoichiometry: 1.0
species: 120928
type: SpeciesReference

102734
stoichiometry: 1.0
species: 120928
type: SpeciesReference

120984
type: Species
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name: PKC active_3.CPI
initial concentration: 0.0
has part: P17252
initial amount: NaN
boundary condition: false
has only substance units: false
constant: false
in compartment: 120775

099379
stoichiometry: 1.0
species: 120920
type: SpeciesReference

100066
stoichiometry: 1.0
species: 121207
type: SpeciesReference

103346
stoichiometry: 1.0
species: 120938
type: SpeciesReference

102794
stoichiometry: 1.0
species: 120928
type: SpeciesReference

121404
kinetic law: 098863
product: 098851
reactant: 098839
reactant: 098827
is: GO:0005220
fast: false
reversible: true
name: C1-8
type: Reaction

101811
units: dimensionless
value: 0.028278
name: ratio
type: LocalParameter

100607
stoichiometry: 1.0
species: 120984
type: SpeciesReference

101079
units: metaid_0000227
value: 4.5099
name: Km
type: LocalParameter

099874
stoichiometry: 1.0
species: 121058
type: SpeciesReference

099838
units: metaid_0000223
value: 0.3
name: kf
type: LocalParameter

096375
exponent: -1.0
scale: 0
multipler: 1.0
kind: SECOND
type: SBMLUnit

101053
stoichiometry: 1.0
species: 121012
type: SpeciesReference

121709
kinetic law: 103899
is: http://identifiers.org/ec-code/2.7.11.18
type: Reaction
reactant: 103862
reversible: false
is: GO:0004687
is: R03150
product: 103874
product: 103887
name: F2-6.1.2
fast: false

120947
is: P17252
constant: false
boundary condition: false
has only substance units: false
initial concentration: 2.0
initial amount: NaN
in compartment: 120775
name: PKC
type: Species

101679
units: metaid_0000224
value: 1.46
name: Vmax
type: LocalParameter

097139
units: metaid_0000223
value: 0.01
name: kf
type: LocalParameter

098235
stoichiometry: 1.0
species: 121202
type: SpeciesReference

099463
stoichiometry: 1.0
species: 120928
type: SpeciesReference

120913
has only substance units: false
initial amount: NaN
has version: C00391
in compartment: 120775
has version: C00076
has version: P62158
constant: false
initial concentration: 0.3
name: Ca_super_2_plus__endsuper_.CaM
type: Species
has version: CHEBI:29108
boundary condition: false

121154
name: MYPT1.Rho-kinase
has only substance units: false
has part: Q13464
boundary condition: false
initial concentration: 0.0
initial amount: NaN
in compartment: 120775
has part: O14974
type: Species
constant: false

101992
stoichiometry: 1.0
species: 121243
type: SpeciesReference

099163
stoichiometry: 1.0
species: 120920
type: SpeciesReference

120967
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 120775
name: csa36_degraded
type: Species

103742
stoichiometry: 1.0
species: 121172
type: SpeciesReference

100486
units: metaid_0000227
value: 0.0014
name: Km
type: LocalParameter

102040
units: dimensionless
value: 7.5865
name: ratio
type: LocalParameter

096460
exponent: -1.0
scale: 0
multipler: 1.0
kind: SECOND
type: SBMLUnit

098525
stoichiometry: 1.0
species: 121227
type: SpeciesReference

121008
type: Species
in compartment: 120775
initial amount: NaN
constant: false
name: MLC
has only substance units: false
initial concentration: 4.3
is version of: P05976
boundary condition: false
is: C03875

098477
units: dimensionless
value: 4.0
name: ratio
type: LocalParameter

100330
units: dimensionless
value: 4.0
name: ratio
type: LocalParameter

100258
units: metaid_0000224
value: 4.63E-5
name: kf
type: LocalParameter

097703
stoichiometry: 1.0
species: 120889
type: SpeciesReference

103238
units: metaid_0000224
value: 3.67
name: Vmax
type: LocalParameter

120989
in compartment: 120775
boundary condition: false
has only substance units: false
initial concentration: 0.0
type: Species
name: CPI-17.MYPT1_PPase
initial amount: NaN
has part: Q96A00
constant: false
has part: O14974

120876
initial amount: NaN
has only substance units: false
is: C00165
in compartment: 120775
boundary condition: false
name: DAG
type: Species
initial concentration: 0.0
constant: false
is: CHEBI:18035

098416
stoichiometry: 1.0
species: 121237
type: SpeciesReference

121637
type: Reaction
reversible: true
name: F2-5.1.1
fast: false
kinetic law: 102866
product: 102854
is: GO:0032027
is part of: R03150
reactant: 102830
reactant: 102842

096949
stoichiometry: 1.0
species: 121077
type: SpeciesReference

121513
reversible: false
fast: false
reactant: 100607
kinetic law: 100643
product: 100631
is: GO:0004697
type: Reaction
name: E2-1.2.3
is: http://identifiers.org/ec-code/2.7.11.13
product: 100619

097175
stoichiometry: 1.0
species: 121069
type: SpeciesReference

121722
kinetic law: 104079
modifier: 104067
product: 104055
reactant: 104043
is: GO:0006816
fast: false
reversible: true
name: D3-2
type: Reaction

099982
units: metaid_0000224
value: 3.0
name: kb
type: LocalParameter

121261
name: A2-1.1
is: GO:0005102
reversible: true
is: GO:0015057
fast: false
is: http://identifiers.org/ec-code/3.4.21.5
product: 096498
kinetic law: 096510
reactant: 096486
type: Reaction
reactant: 096474

100270
stoichiometry: 1.0
species: 121058
type: SpeciesReference

103814
stoichiometry: 1.0
species: 121127
type: SpeciesReference

099427
units: metaid_0000223
value: 10.0
name: kf
type: LocalParameter

102088
stoichiometry: 1.0
species: 121139
type: SpeciesReference

120775
is: GO:0005829
constant: true
size: 1.0
spatial dimensions: 3.0
name: cytosol
type: Compartment

121281
kinetic law: 096910
product: 096897
reactant: 096884
is: GO:0003924
fast: false
reversible: false
name: A1-6
type: Reaction

097643
stoichiometry: 1.0
species: 121069
type: SpeciesReference

097223
stoichiometry: 1.0
species: 120899
type: SpeciesReference

096412
exponent: 2.0
scale: 0
multipler: 1.0
kind: LITRE
type: SBMLUnit

098199
units: metaid_0000224
value: 1.0
name: kb
type: LocalParameter

102383
stoichiometry: 1.0
species: 121008
type: SpeciesReference

120961
is: P17252
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 120775
name: PKC active_3
type: Species

102318
stoichiometry: 1.0
species: 121127
type: SpeciesReference

102529
units: metaid_0000224
value: 0.2
name: kf
type: LocalParameter

100884
units: metaid_0000223
value: 100.0
name: kf
type: LocalParameter

099609
stoichiometry: 1.0
species: 120950
type: SpeciesReference

099115
stoichiometry: 1.0
species: 120917
type: SpeciesReference

121478
reversible: true
product: 100018
type: Reaction
reactant: 100006
reactant: 099994
kinetic law: 100030
name: E1-7
is: GO:0019992
is part of: GO:0007205
fast: false

103010
stoichiometry: 1.0
species: 120938
type: SpeciesReference

098947
units: metaid_0000223
value: 150.0
name: g
type: LocalParameter

097115
stoichiometry: 1.0
species: 121097
type: SpeciesReference

121611
fast: false
is: GO:0050115
product: 102383
reversible: false
reactant: 102370
name: F2-12.2
product: 102396
type: Reaction
is: http://identifiers.org/ec-code/3.1.3.53
kinetic law: 102408
is: R03151

121690
name: F2-6.2.2
type: Reaction
is: R03150
is: GO:0004687
fast: false
product: 103754
product: 103766
reactant: 103742
reversible: false
kinetic law: 103778
is: http://identifiers.org/ec-code/2.7.11.18

121316
kinetic law: 097499
product: 097487
product: 097475
reactant: 097463
is: GO:0005089
fast: false
reversible: false
name: B2-1.2
type: Reaction

102842
stoichiometry: 1.0
species: 120932
type: SpeciesReference

121677
kinetic law: 103538
fast: false
is: R03150
product: 103526
type: Reaction
reactant: 103502
reversible: false
is: http://identifiers.org/ec-code/2.7.11.18
name: F2-6.4.2
is: GO:0004687
product: 103514

097741
units: metaid_0000224
value: 3.667E-4
name: kf
type: LocalParameter

099814
stoichiometry: 1.0
species: 121219
type: SpeciesReference

103586
stoichiometry: 1.0
species: 120941
type: SpeciesReference

121650
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product: 103106
is part of: R03150
reactant: 103094
reversible: true
name: F2-5.4.1
reactant: 103082
kinetic law: 103118
type: Reaction
is: GO:0032027

099766
units: metaid_0000224
value: 1.2705
name: kf
type: LocalParameter

101835
stoichiometry: 1.0
species: 121154
type: SpeciesReference

101247
units: metaid_0000224
value: 1.28
name: Vmax
type: LocalParameter

096692
units: metaid_0000224
value: 0.00224
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type: LocalParameter

121497
kinetic law: 100306
product: 100294
reactant: 100282
reactant: 100270
is: GO:0051928
fast: false
reversible: true
name: D2-1.1
type: Reaction

100018
stoichiometry: 1.0
species: 121207
type: SpeciesReference

121633
product: 102794
is: http://identifiers.org/ec-code/2.7.11.18
type: Reaction
reactant: 102770
reversible: false
is: GO:0004687
fast: false
kinetic law: 102806
is: R03150
product: 102782
name: F2-8.2

099331
stoichiometry: 1.0
species: 120941
type: SpeciesReference

121386
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kinetic law: 098634
product: 098609
is: GO:0004435
product: 098622
is: http://identifiers.org/ec-code/3.1.4.11
type: Reaction
product: 098597
is: R03435
reversible: false
fast: false
reactant: 098585

121536
kinetic law: 101005
product: 100993
reactant: 100981
is: GO:0006470
fast: false
reversible: false
name: E1-13
type: Reaction

103214
units: metaid_0000227
value: 10.019
name: Km
type: LocalParameter

098501
stoichiometry: 1.0
species: 121202
type: SpeciesReference

103874
stoichiometry: 1.0
species: 121002
type: SpeciesReference

100969
units: metaid_0000224
value: 0.1
name: kb
type: LocalParameter

100354
stoichiometry: 1.0
species: 120961
type: SpeciesReference

098127
units: metaid_0000224
value: 1.0
name: kb
type: LocalParameter

W3 CDTF: Sat Sep 30 18:25:23 BST 2006

121516
name: E2-1.2.2
reversible: false
is: http://identifiers.org/ec-code/2.7.11.13
product: 100691
kinetic law: 100703
fast: false
type: Reaction
product: 100679
reactant: 100667
is: GO:0004698

100908
stoichiometry: 1.0
species: 121243
type: SpeciesReference

121077
initial amount: NaN
constant: false
has part: Q03113
type: Species
has part: CHEBI:17552
initial concentration: 0.0
has part: C00035
boundary condition: false
in compartment: 120775
has only substance units: false
name: G_sub_12_endsub__alpha_.GDP

100234
stoichiometry: 1.0
species: 120970
type: SpeciesReference

120872
initial concentration: 0.1
type: Species
has only substance units: false
boundary condition: false
initial amount: NaN
constant: false
is: Q9NRY4
in compartment: 120775
is: IPR008936
name: RhoGAP

121471
kinetic law: 099958
product: 099946
reactant: 099934
reactant: 099922
is: GO:0051928
fast: false
reversible: true
name: D1-1
type: Reaction

120851
type: Species
is: C00035
initial amount: NaN
has only substance units: false
is: CHEBI:17552
name: GDP
boundary condition: true
constant: false
initial concentration: 5.0
in compartment: 120775

102214
units: dimensionless
value: 7.5865
name: ratio
type: LocalParameter

102505
stoichiometry: 1.0
species: 121243
type: SpeciesReference

096884
stoichiometry: 1.0
species: 121082
type: SpeciesReference

120812
is: IPR000935
constant: false
initial amount: NaN
boundary condition: false
in compartment: 120775
type: Species
has only substance units: false
name: thrombinR active
is: P25116
initial concentration: 0.0

103670
units: metaid_0000224
value: 3.67
name: Vmax
type: LocalParameter

121346
reactant: 097909
name: A1-1
fast: false
is: GO:0015057
is: GO:0004930
reversible: true
product: 097921
reactant: 097897
type: Reaction
kinetic law: 097933

100667
stoichiometry: 1.0
species: 120979
type: SpeciesReference

096436
exponent: -3.0
scale: -6
multipler: 1.0
kind: MOLE
type: SBMLUnit

121614
reactant: 102433
is: http://identifiers.org/ec-code/3.1.3.53
kinetic law: 102469
fast: false
product: 102445
is: GO:0050115
is: R03151
type: Reaction
product: 102457
reversible: false
name: F2-10.2

099403
stoichiometry: 1.0
species: 120938
type: SpeciesReference

096486
stoichiometry: 1.0
species: 120806
type: SpeciesReference

102064
stoichiometry: 1.0
species: 121127
type: SpeciesReference

102253
stoichiometry: 1.0
species: 121127
type: SpeciesReference

100294
stoichiometry: 1.0
species: 121110
type: SpeciesReference

121285
kinetic law: 096975
product: 096962
reactant: 096949
reactant: 096936
is: GO:0031684
fast: false
reversible: false
name: A1-7
type: Reaction

097199
units: metaid_0000223
value: 20.0
name: kf
type: LocalParameter

101631
stoichiometry: 1.0
species: 121130
type: SpeciesReference

121653
reactant: 103166
is: GO:0032027
fast: false
reversible: true
product: 103190
reactant: 103178
kinetic law: 103202
is part of: R03150
name: F2-6.1.1
type: Reaction

102175
stoichiometry: 1.0
species: 121142
type: SpeciesReference

098380
stoichiometry: 1.0
species: 121086
type: SpeciesReference

101547
stoichiometry: 1.0
species: 121115
type: SpeciesReference

099705
units: metaid_0000223
value: 3.0E-4
name: kf
type: LocalParameter

121288
kinetic law: 097041
product: 097028
reactant: 097015
reactant: 097001
is: GO:0016299
fast: false
reversible: true
name: A2-2.1
type: Reaction

099031
stoichiometry: 1.0
species: 121026
type: SpeciesReference

121539
kinetic law: 101066
product: 101053
reactant: 101041
reactant: 101029
is: GO:0032027
fast: false
reversible: true
name: F2-1.1
type: Reaction

101223
stoichiometry: 1.0
species: 120869
type: SpeciesReference

101919
stoichiometry: 1.0
species: 121133
type: SpeciesReference

120834
initial amount: NaN
has only substance units: false
in compartment: 120775
is: P25116
type: Species
is: IPR000935
initial concentration: 0.0
boundary condition: false
constant: false
name: thrombinR

097765
stoichiometry: 1.0
species: 120889
type: SpeciesReference

099742
stoichiometry: 1.0
species: 120958
type: SpeciesReference

103562
stoichiometry: 1.0
species: 121163
type: SpeciesReference

101859
stoichiometry: 1.0
species: 121247
type: SpeciesReference

orgname: California Institute of Technology

given: Harish
family: Dharuri

W3 CDTF: Thu Jul 05 17:29:02 BST 2012