metaid_0000006
initial amount: NaN
name: A
type: Species
has only substance units: false
is version of: IPR000342
initial concentration: 0.0
in compartment: metaid_0000005
notes: GAP
boundary condition: false
constant: false

metaid_0000031
is version of: GO:0005102
is version of: GO:0001664
name: G*T binding Receptor
type: Reaction
fast: false
kinetic law: 143230
reactant: 143194
product: 143218
reversible: true
reactant: 143206

metaid_0000045
reversible: true
product: 144000
product: 144012
reactant: 143988
is version of: GO:0003924
fast: false
has version: REACT 348
name: RG*AT hydrolysis
type: Reaction
kinetic law: 144024

143399
value: 0.95
type: LocalParameter

metaid_0000039
kinetic law: 143736
product: 143724
product: 143712
reactant: 143700
is version of: GO:0043241
fast: false
reversible: true
name: GAD dissociation
type: Reaction

143784
stoichiometry: 1.0
species: metaid_0000010
type: SpeciesReference

143038
value: 9.03E-7
type: LocalParameter

metaid_0000019
has part: GO:0043235
has part: GO:0005834
initial amount: NaN
in compartment: metaid_0000005
boundary condition: false
type: Species
has part: CHEBI:17552
initial concentration: 0.0
constant: false
name: RGD
has only substance units: false

143820
value: 3.96E9
type: LocalParameter

143964
value: 6300000.0
type: LocalParameter

143543
value: 2.22E-9
type: LocalParameter

143098
value: 1.0E-4
type: LocalParameter

143676
value: 25.0
type: LocalParameter

143062
stoichiometry: 1.0
species: metaid_0000007
type: SpeciesReference

metaid_0000011
in compartment: metaid_0000005
type: Species
name: G*T
has only substance units: false
notes: active G protein
has part: CHEBI:15996
constant: false
has part: GO:0005834
boundary condition: false
initial amount: NaN
initial concentration: 0.0

143134
stoichiometry: 1.0
species: metaid_0000009
type: SpeciesReference

143411
stoichiometry: 1.0
species: metaid_0000012
type: SpeciesReference

143579
stoichiometry: 1.0
species: metaid_0000014
type: SpeciesReference

metaid_0000007
initial concentration: 1.0E-8
constant: false
initial amount: NaN
type: Species
notes: inactive G protein
has only substance units: false
is version of: GO:0005834
in compartment: metaid_0000005
boundary condition: false
name: G

143327
value: 0.0408
type: LocalParameter

143267
stoichiometry: 1.0
species: metaid_0000011
type: SpeciesReference

metaid_0000030
is version of: GO:0032403
name: RG binding GTP
reactant: 143122
reversible: true
product: 143146
is version of: GO:0005525
fast: false
type: Reaction
reactant: 143134
kinetic law: 143158

metaid_0000044
reactant: 143928
is version of: GO:0032403
reversible: true
fast: false
reactant: 143916
kinetic law: 143952
is version of: GO:0005102
product: 143940
type: Reaction
name: RG*T binding GAP

metaid_0000038
product: 143640
is version of: GO:0003924
fast: false
kinetic law: 143664
type: Reaction
reversible: true
product: 143652
name: G*AT hydrolysis
has version: REACT 348
reactant: 143628

142954
value: 529000.0
type: LocalParameter

143616
value: 1470000.0
type: LocalParameter

143868
stoichiometry: 1.0
species: metaid_0000021
type: SpeciesReference

metaid_0000018
has part: IPR000342
type: Species
constant: false
has only substance units: false
boundary condition: false
has part: CHEBI:17552
initial concentration: 0.0
has part: GO:0005834
name: GAD
initial amount: NaN
in compartment: metaid_0000005

143194
stoichiometry: 1.0
species: metaid_0000011
type: SpeciesReference

metaid_0000010
in compartment: metaid_0000005
is version of: GO:0043235
type: Species
has version: IPR000337
boundary condition: false
has only substance units: false
constant: false
notes: Receptor
initial concentration: 1.0E-5
name: R
initial amount: NaN

143435
stoichiometry: 1.0
species: metaid_0000019
type: SpeciesReference

metaid_0000033
kinetic law: 143375
product: 143363
reactant: 143351
reactant: 143339
is version of: GO:0032403
fast: false
reversible: true
name: GD binding GAP
type: Reaction

metaid_0000008
boundary condition: false
type: Species
has only substance units: false
initial concentration: 0.0
in compartment: metaid_0000005
name: GA
has part: IPR000342
constant: false
initial amount: NaN
has part: GO:0005834

143387
value: 64100.0
type: LocalParameter

143254
value: 1.28
type: LocalParameter

143724
stoichiometry: 1.0
species: metaid_0000014
type: SpeciesReference

144012
stoichiometry: 1.0
species: metaid_0000013
type: SpeciesReference

143976
value: 0.478
type: LocalParameter

143688
value: 0.244
type: LocalParameter

143495
stoichiometry: 1.0
species: metaid_0000019
type: SpeciesReference

143122
stoichiometry: 1.0
species: metaid_0000015
type: SpeciesReference

142978
stoichiometry: 1.0
species: metaid_0000011
type: SpeciesReference

143796
stoichiometry: 1.0
species: metaid_0000020
type: SpeciesReference

143555
stoichiometry: 1.0
species: metaid_0000019
type: SpeciesReference

metaid_0000013
is: CHEBI:18367
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0044
initial amount: NaN
in compartment: metaid_0000005
name: Pi
type: Species

metaid_0000032
kinetic law: 143303
product: 143291
reactant: 143279
reactant: 143267
is version of: GO:0032403
fast: false
reversible: true
name: G*T binding GAP
type: Reaction

metaid_0000009
notes: GTP
has only substance units: false
is: C00044
constant: false
in compartment: metaid_0000005
boundary condition: false
type: Species
is: CHEBI:15996
name: T
initial concentration: 4.68E-4
initial amount: NaN

144084
stoichiometry: 1.0
species: metaid_0000014
type: SpeciesReference

143206
stoichiometry: 1.0
species: metaid_0000010
type: SpeciesReference

143423
stoichiometry: 1.0
species: metaid_0000010
type: SpeciesReference

143291
stoichiometry: 1.0
species: metaid_0000017
type: SpeciesReference

142966
value: 8.38E-6
type: LocalParameter

143074
stoichiometry: 1.0
species: metaid_0000014
type: SpeciesReference

143567
stoichiometry: 1.0
species: metaid_0000015
type: SpeciesReference

143351
stoichiometry: 1.0
species: metaid_0000006
type: SpeciesReference

143339
stoichiometry: 1.0
species: metaid_0000012
type: SpeciesReference

144000
stoichiometry: 1.0
species: metaid_0000022
type: SpeciesReference

metaid_0000042
product: 143868
is version of: GO:0032403
reactant: 143856
reversible: true
fast: false
is version of: GO:0005525
reactant: 143844
name: RGA binding GTP
kinetic law: 143880
type: Reaction

143002
stoichiometry: 1.0
species: metaid_0000013
type: SpeciesReference

metaid_0000022
initial amount: NaN
in compartment: metaid_0000005
has part: IPR000342
type: Species
boundary condition: false
initial concentration: 0.0
name: RGAD
has part: CHEBI:17552
has only substance units: false
constant: false
has part: GO:0043235
has part: GO:0005834

143640
stoichiometry: 1.0
species: metaid_0000018
type: SpeciesReference

BIOMD0000000085
reaction: metaid_0000039
species: metaid_0000006
species: metaid_0000013
reaction: metaid_0000030
reaction: metaid_0000045
reaction: metaid_0000028
reaction: metaid_0000042
species: metaid_0000011
reaction: metaid_0000029
species: metaid_0000018
reaction: metaid_0000041
reaction: metaid_0000034
time units: metaid_0000007
notes: This model is according to the paper Reduced-order modeling of biochemical networks: application to the GTPase-cycle signalling module by Maurya et al 2006.The figure 4c is reproduced by Copasi 4.0.19 (development) .It is three-dimensional logarithmic plots show the output of simulations of Z at various concentrations of R and GAP. To the extent possible under law, all copyright and related or neighbouring rights to this encoded model have been dedicated to the public domain worldwide. Please refer to CC0 Public Domain Dedication for more information. In summary, you are entitled to use this encoded model in absolutely any manner you deem suitable, verbatim, or with modification, alone or embedded it in a larger context, redistribute it, commercially or not, in a restricted way or not. To cite BioModels Database, please use: Li C, Donizelli M, Rodriguez N, Dharuri H, Endler L, Chelliah V, Li L, He E, Henry A, Stefan MI, Snoep JL, Hucka M, Le Novère N, Laibe C (2010) BioModels Database: An enhanced, curated and annotated resource for published quantitative kinetic models. BMC Syst Biol., 4:92.
length unit: length
species: metaid_0000008
species: metaid_0000012
reaction: metaid_0000032
species: metaid_0000022
reaction: metaid_0000026
is: MODEL5317679037
reaction: metaid_0000044
species: metaid_0000010
reaction: metaid_0000031
species: metaid_0000017
created:
  W3 CDTF: Wed Nov 29 17:40:19 GMT 2006
parameter: metaid_0000003
modified:
  W3 CDTF: Thu Jul 05 17:29:16 BST 2012
species: metaid_0000015
area units: metaid_0000005
reaction: metaid_0000036
species: metaid_0000021
reaction: metaid_0000048
reaction: metaid_0000035
species: metaid_0000009
is described by: http://identifiers.org/pubmed/16986265
reaction: metaid_0000038
substance units: metaid_0000020
reaction: metaid_0000033
species: metaid_0000007
volume units: metaid_0000004
compartment: metaid_0000005
parameter: metaid_0000004
species: metaid_0000016
is version of: GO:0008277
rule: metaid_0000040
type: SBMLModel
curated: true
species: metaid_0000014
name: Maurya2005_GTPaseCycle_reducedOrder
rule: metaid_0000043
species: metaid_0000020
species: metaid_0000019
occurs in: http://identifiers.org/taxonomy/131567
creator:
  ORG:
    orgname: University of Oxford
  n:
    given: Enuo
    family: He

143628
stoichiometry: 1.0
species: metaid_0000017
type: SpeciesReference

143856
stoichiometry: 1.0
species: metaid_0000009
type: SpeciesReference

metaid_0000012
boundary condition: false
in compartment: metaid_0000005
is: CHEBI:17552
has only substance units: false
name: GD
initial concentration: 0.0
type: Species
initial amount: NaN
constant: false
is: GO:0005834

metaid_0000015
boundary condition: false
in compartment: metaid_0000005
has only substance units: false
initial concentration: 0.0
type: Species
has part: GO:0043235
has part: GO:0005834
initial amount: NaN
name: RG
constant: false

143652
stoichiometry: 1.0
species: metaid_0000013
type: SpeciesReference

metaid_0000035
product: 143495
name: RG*T hydrolysis
type: Reaction
reversible: true
has version: REACT 348
kinetic law: 143519
product: 143507
reactant: 143483
is version of: GO:0003924
fast: false

143892
value: 1620000.0
type: LocalParameter

142918
stoichiometry: 1.0
species: metaid_0000009
type: SpeciesReference

143988
stoichiometry: 1.0
species: metaid_0000021
type: SpeciesReference

143712
stoichiometry: 1.0
species: metaid_0000008
type: SpeciesReference

143483
stoichiometry: 1.0
species: metaid_0000016
type: SpeciesReference

144048
value: 0.00297
type: LocalParameter

metaid_0000029
kinetic law: 143086
product: 143074
product: 143062
reactant: 143050
is version of: GO:0043241
fast: false
reversible: true
name: GD dissociation
type: Reaction

metaid_0000021
boundary condition: false
initial concentration: 0.0
has part: IPR000342
has part: GO:0005834
initial amount: NaN
in compartment: metaid_0000005
name: RG*AT
type: Species
has part: CHEBI:15996
has part: GO:0043235
has only substance units: false
constant: false

143218
stoichiometry: 1.0
species: metaid_0000016
type: SpeciesReference

142904
stoichiometry: 1.0
species: metaid_0000007
type: SpeciesReference

143916
stoichiometry: 1.0
species: metaid_0000016
type: SpeciesReference

143748
value: 1.0E-4
type: LocalParameter

143904
value: 0.00875
type: LocalParameter

143760
value: 3.83
type: LocalParameter

metaid_0000014
initial amount: NaN
is: C00035
constant: false
is: CHEBI:17552
initial concentration: 1.49E-4
in compartment: metaid_0000005
has only substance units: false
notes: GDP
name: D
boundary condition: false
type: Species

metaid_0000048
kinetic law: 144096
product: 144084
product: 144072
reactant: 144060
is version of: GO:0043241
fast: false
reversible: true
name: RGAD dissociation
type: Reaction

143844
stoichiometry: 1.0
species: metaid_0000020
type: SpeciesReference

143170
value: 853000.0
type: LocalParameter

143940
stoichiometry: 1.0
species: metaid_0000021
type: SpeciesReference

143507
stoichiometry: 1.0
species: metaid_0000013
type: SpeciesReference

metaid_0000034
is version of: GO:0001664
reactant: 143423
name: GD binding Receptor
is version of: GO:0005102
kinetic law: 143447
reactant: 143411
type: Reaction
product: 143435
fast: false
reversible: true

metaid_0000028
has version: REACT 348
is version of: GO:0003924
kinetic law: 143014
product: 143002
fast: false
product: 142990
type: Reaction
reactant: 142978
name: G*T hydrolysis
reversible: true

143363
stoichiometry: 1.0
species: metaid_0000018
type: SpeciesReference

142990
stoichiometry: 1.0
species: metaid_0000012
type: SpeciesReference

metaid_0000003
notes: fractional activity of G proteins
constant: false
value: 0.0
name: Z
type: Parameter

metaid_0000041
product: 143796
reactant: 143772
kinetic law: 143808
is version of: GO:0001664
reversible: true
is version of: GO:0005102
name: GA binding Receptor
type: Reaction
fast: false
reactant: 143784

142930
stoichiometry: 1.0
species: metaid_0000011
type: SpeciesReference

144072
stoichiometry: 1.0
species: metaid_0000020
type: SpeciesReference

metaid_0000020
boundary condition: false
initial concentration: 0.0
initial amount: NaN
in compartment: metaid_0000005
has part: IPR000342
has part: GO:0043235
has only substance units: false
type: Species
name: RGA
constant: false
has part: GO:0005834

144120
value: 2940.0
type: LocalParameter

144108
value: 2.75
type: LocalParameter

143531
value: 0.013
type: LocalParameter

144036
value: 25.0
type: LocalParameter

143050
stoichiometry: 1.0
species: metaid_0000012
type: SpeciesReference

143471
value: 0.00227
type: LocalParameter

143146
stoichiometry: 1.0
species: metaid_0000016
type: SpeciesReference

143700
stoichiometry: 1.0
species: metaid_0000018
type: SpeciesReference

metaid_0000004
notes: GTP hydrolytic rate
constant: false
value: 0.0
name: v
type: Parameter

143459
value: 9.47E7
type: LocalParameter

143928
stoichiometry: 1.0
species: metaid_0000006
type: SpeciesReference

metaid_0000017
type: Species
constant: false
name: G*AT
has part: GO:0005834
has part: IPR000342
boundary condition: false
initial concentration: 0.0
in compartment: metaid_0000005
has only substance units: false
initial amount: NaN
has part: CHEBI:15996

143026
value: 0.013
type: LocalParameter

143772
stoichiometry: 1.0
species: metaid_0000008
type: SpeciesReference

143110
value: 62.3
type: LocalParameter

metaid_0000026
type: Reaction
is version of: GO:0005525
name: G protein binding GTP
kinetic law: 142942
is version of: GO:0005515
reactant: 142904
reactant: 142918
reversible: true
product: 142930
fast: false

metaid_0000005
is version of: GO:0005623
constant: true
size: 1.0
spatial dimensions: 3.0
name: cell
type: Compartment

143832
value: 5.43E-5
type: LocalParameter

metaid_0000036
kinetic law: 143591
product: 143579
product: 143567
reactant: 143555
is version of: GO:0043241
fast: false
reversible: true
name: RGD dissociation
type: Reaction

143182
value: 0.00468
type: LocalParameter

143603
value: 2.0
type: LocalParameter

144060
stoichiometry: 1.0
species: metaid_0000022
type: SpeciesReference

143242
value: 1.32E8
type: LocalParameter

metaid_0000016
in compartment: metaid_0000005
has only substance units: false
initial amount: NaN
boundary condition: false
initial concentration: 0.0
has part: GO:0043235
type: Species
constant: false
has part: CHEBI:15996
has part: GO:0005834
name: RG*T

143315
value: 386000.0
type: LocalParameter

143279
stoichiometry: 1.0
species: metaid_0000006
type: SpeciesReference