105208
stoichiometry: 1.0
species: metaid_0000007
type: SpeciesReference

105135
stoichiometry: 1.0
species: metaid_0000005
type: SpeciesReference

105304
value: 0.3
type: LocalParameter

metaid_0000003
is: GO:0005829
constant: true
size: 1.0
spatial dimensions: 3.0
name: Cytosol
type: Compartment

105584
value: 1.0
type: LocalParameter

105608
value: 1.0
type: LocalParameter

105512
value: 1.0
type: LocalParameter

metaid_0000007
is version of: P04049
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: metaid_0000003
type: Species

metaid_0000013
kinetic law: 105159
product: 105147
reactant: 105135
is version of: GO:0045741
fast: false
reversible: true
name: Receptor activation
type: Reaction

metaid_0000017
kinetic law: 105428
product: 105415
reactant: 105403
is: GO:0051389
fast: false
reversible: true
name: Kinase-2 inactivation
type: Reaction

105183
value: 0.1
type: LocalParameter

105403
stoichiometry: 1.0
species: metaid_0000009
type: SpeciesReference

105123
value: 0.1
type: LocalParameter

105257
value: 0.1
type: LocalParameter

105440
value: 0.3
type: LocalParameter

105536
stoichiometry: 1.0
species: metaid_0000011
type: SpeciesReference

105342
stoichiometry: 1.0
species: metaid_0000009
type: SpeciesReference

105147
stoichiometry: 1.0
species: metaid_0000004
type: SpeciesReference

105075
stoichiometry: 1.0
species: metaid_0000004
type: SpeciesReference

metaid_0000012
kinetic law: 105099
product: 105087
reactant: 105075
is version of: GO:0007175
fast: false
reversible: true
name: Receptor inactivation
type: Reaction

metaid_0000006
is version of: P04049
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 1.0
in compartment: metaid_0000003
type: Species

105316
value: 1.0
type: LocalParameter

105464
stoichiometry: 1.0
species: metaid_0000010
type: SpeciesReference

metaid_0000016
type: Reaction
modifier: 105354
is: http://identifiers.org/ec-code/2.7.11.1
kinetic law: 105366
fast: false
is: GO:0000186
name: Kinase-2 activation
is: GO:0004709
reversible: true
reactant: 105329
product: 105342

105379
value: 1.0
type: LocalParameter

105596
value: 0.0
type: LocalParameter

105391
value: 0.1
type: LocalParameter

105524
value: 0.1
type: LocalParameter

105329
stoichiometry: 1.0
species: metaid_0000008
type: SpeciesReference

105195
stoichiometry: 1.0
species: metaid_0000006
type: SpeciesReference

metaid_0000005
is version of: Q9QX70
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: metaid_0000003
type: Species

metaid_0000019
kinetic law: 105560
product: 105548
reactant: 105536
is version of: GO:0043407
fast: false
reversible: true
name: Kinase-3 inactivation
type: Reaction

metaid_0000015
kinetic law: 105292
product: 105280
reactant: 105268
is: GO:0051390
fast: false
reversible: true
name: Kinase-1 inactivation
type: Reaction

metaid_0000009
is version of: Q02750
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: metaid_0000003
type: Species

105572
value: 0.3
type: LocalParameter

BIOMD0000000084
reaction: metaid_0000015
reaction: metaid_0000013
modified:
  W3 CDTF: Mon May 14 13:15:35 BST 2012
species: metaid_0000005
created:
  W3 CDTF: Mon Dec 11 10:48:55 GMT 2006
type: SBMLModel
is: GO:0000165
species: metaid_0000004
reaction: metaid_0000018
is described by: http://identifiers.org/pubmed/15634347
is: GO:0007173
time units: metaid_0000007
name: Hornberg2005_ERKcascade
species: metaid_0000007
reaction: metaid_0000017
species: metaid_0000009
species: metaid_0000011
reaction: metaid_0000019
species: metaid_0000006
species: metaid_0000008
creator:
  ORG:
    orgname: California Institute of Technology
  n:
    given: Harish
    family: Dharuri
curated: true
notes: SBML level 2 code generated for the JWS Online project by Jacky Snoep using PySCeS Run this model online at http://jjj.biochem.sun.ac.za To cite JWS Online please refer to: Olivier, B.G. and Snoep, J.L. (2004) Web-based modelling using JWS Online , Bioinformatics, 20:2143-2144 Biomodels Curation The model reproduces the time series depicted in Fig 2 of the paper. Also, by varying the values of Vmax for the second kinase (k5) the time series of X3P as shown in Fig3 can be reproduced. The model was successfully tested on MathSBML and Jarnac.
volume units: metaid_0000004
area units: metaid_0000005
is: MODEL6623610941
occurs in: http://identifiers.org/taxonomy/40674
reaction: metaid_0000012
units def: metaid_0000020
reaction: metaid_0000014
compartment: metaid_0000003
has part: rno04010
substance units: metaid_0000020
species: metaid_0000010
length unit: length
reaction: metaid_0000016

metaid_0000011
is version of: P28482
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: metaid_0000003
type: Species

105548
stoichiometry: 1.0
species: metaid_0000010
type: SpeciesReference

105452
value: 1.0
type: LocalParameter

metaid_0000014
kinetic law: 105232
modifier: 105220
product: 105208
reactant: 105195
is: GO:0000185
fast: false
reversible: true
name: Kinase-1 activation
type: Reaction

105171
value: 0.01
type: LocalParameter

105111
value: 1.0
type: LocalParameter

105063
exponent: 1.0
scale: 0
multipler: 1.0
kind: ITEM
type: SBMLUnit

metaid_0000020
unit: 105063
name: dimensionless
type: SBMLUnitsDef

105415
stoichiometry: 1.0
species: metaid_0000008
type: SpeciesReference

105280
stoichiometry: 1.0
species: metaid_0000006
type: SpeciesReference

105244
value: 1.0
type: LocalParameter

metaid_0000018
name: Kinase-3 activation
kinetic law: 105500
modifier: 105488
type: Reaction
is: http://identifiers.org/ec-code/2.7.12.2
is: GO:0004708
fast: false
reactant: 105464
is: GO:0000187
reversible: true
product: 105476

metaid_0000004
is version of: Q9QX70
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.5
in compartment: metaid_0000003
type: Species

105476
stoichiometry: 1.0
species: metaid_0000011
type: SpeciesReference

105268
stoichiometry: 1.0
species: metaid_0000007
type: SpeciesReference

metaid_0000008
is version of: Q02750
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 1.0
in compartment: metaid_0000003
type: Species

metaid_0000010
is version of: P28482
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 1.0
in compartment: metaid_0000003
type: Species

105087
stoichiometry: 1.0
species: metaid_0000005
type: SpeciesReference