030338
value: 0.1
type: LocalParameter

030446
stoichiometry: 1.0
species: metaid_0000010
type: SpeciesReference

030350
stoichiometry: 1.0
species: metaid_0000006
type: SpeciesReference

030205
stoichiometry: 1.0
species: metaid_0000004
type: SpeciesReference

030542
value: 1.0
type: LocalParameter

metaid_0000004
is: CHEBI:35569
constant: false
boundary condition: false
has only substance units: false
initial concentration: 3.1E-5
initial amount: NaN
in compartment: metaid_0000003
name: D
type: Species

metaid_0000018
kinetic law: 030530
product: 030518
product: 030506
reactant: 030494
is version of: GO:0043241
fast: false
reversible: false
name: G protein activation
type: Reaction

metaid_0000008
has part: P18825
initial amount: NaN
has only substance units: false
initial concentration: 0.0
name: DRG
in compartment: metaid_0000003
has part: CHEBI:35569
constant: false
has part: P18089
boundary condition: false
has part: P08913
type: Species
has part: GO:0005834

030494
stoichiometry: 1.0
species: metaid_0000010
type: SpeciesReference

metaid_0000014
kinetic law: 030241
product: 030229
reactant: 030217
reactant: 030205
is version of: GO:0031690
fast: false
reversible: true
name: Forming DR
type: Reaction

metaid_0000010
has part: P18089
in compartment: metaid_0000003
boundary condition: false
has part: CHEBI:35569
initial concentration: 0.0
name: DRG_GTP
has part: P08913
has part: P18825
has part: CHEBI:15996
initial amount: NaN
has part: GO:0005834
type: Species
constant: false
has only substance units: false

metaid_0000011
is: CHEBI:15996
constant: false
boundary condition: false
has only substance units: false
initial concentration: 1.0E-5
initial amount: NaN
in compartment: metaid_0000003
name: GTP
type: Species

030566
stoichiometry: 1.0
species: metaid_0000007
type: SpeciesReference

030518
stoichiometry: 1.0
species: metaid_0000005
type: SpeciesReference

030590
value: 2.0
type: LocalParameter

030277
stoichiometry: 1.0
species: metaid_0000005
type: SpeciesReference

metaid_0000005
has part: P18089
has part: P18825
in compartment: metaid_0000003
has only substance units: false
constant: false
boundary condition: false
has part: P08913
name: DR
has part: CHEBI:35569
initial concentration: 0.0
initial amount: NaN
type: Species

030362
stoichiometry: 1.0
species: metaid_0000009
type: SpeciesReference

030470
value: 5000000.0
type: LocalParameter

metaid_0000009
is: CHEBI:17552
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: metaid_0000003
name: GDP
type: Species

030422
stoichiometry: 1.0
species: metaid_0000008
type: SpeciesReference

030253
value: 5000000.0
type: LocalParameter

metaid_0000019
kinetic law: 030578
product: 030566
reactant: 030554
is version of: GO:0003924
fast: false
reversible: false
name: Hydrolysis of GTP to GDP
type: Reaction

metaid_0000015
kinetic law: 030314
product: 030302
reactant: 030289
reactant: 030277
is version of: GO:0001664
fast: false
reversible: true
name: DR Binding with G_GDP produce DRG_GDP
type: Reaction

030217
stoichiometry: 1.0
species: metaid_0000013
type: SpeciesReference

metaid_0000012
type: Species
in compartment: metaid_0000003
has part: GO:0005834
boundary condition: false
initial amount: NaN
initial concentration: 0.0
has only substance units: false
has part: CHEBI:15996
name: G_GTP
constant: false

030398
value: 5.0
type: LocalParameter

030326
value: 1.0E8
type: LocalParameter

030434
stoichiometry: 1.0
species: metaid_0000011
type: SpeciesReference

030302
stoichiometry: 1.0
species: metaid_0000006
type: SpeciesReference

BIOMD0000000080
creator:
  ORG:
    orgname: University of Oxford
  n:
    given: Enuo
    family: He
reaction: metaid_0000017
species: metaid_0000005
reaction: metaid_0000019
species: metaid_0000006
curated: true
is version of: GO:0007194
type: SBMLModel
reaction: metaid_0000014
species: metaid_0000007
is: MODEL1173806337
notes: This model reproduces figure 5 and figure 4(B)of the paper, with Kinh represented by [G-GTP]. We arbitrarily chosed to set the initial concentration of D to 31 micorMolar based on legend of figure 4. [R] was not given anywhere in the paper and was chosen to calibrate the sigmoid response to an increased [GTP]. THe figure 5 in the model was successfully simulated on COPASI 4.0 ,the figure 4(B) was sucessfully simulated on both COPASI and SBML_odeSolver. There are two curves for Kinh in the absence and presence of NaCl in the figure obtained from simulations of the model using parameters of set C and set D.Here in the model the initial value given is from set D.The parameters in set C :k7=0.5, k10=1.0,k5=0.1,the others are the same with set D.
reaction: metaid_0000016
species: metaid_0000011
area units: metaid_0000005
compartment: metaid_0000003
name: Thomsen1989_AdenylateCyclase
species: metaid_0000012
length unit: length
modified:
  W3 CDTF: Fri Apr 20 20:09:08 BST 2012
occurs in: http://identifiers.org/taxonomy/9606
time units: metaid_0000021
reaction: metaid_0000015
reaction: metaid_0000018
species: metaid_0000013
is described by: http://identifiers.org/pubmed/2574993
is version of: GO:0031684
species: metaid_0000008
volume units: metaid_0000004
species: metaid_0000009
species: metaid_0000004
substance units: metaid_0000022
species: metaid_0000010
created:
  W3 CDTF: Wed Sep 27 11:07:57 BST 2006

030554
stoichiometry: 1.0
species: metaid_0000012
type: SpeciesReference

metaid_0000016
kinetic law: 030386
product: 030374
product: 030362
reactant: 030350
is version of: GO:0043241
fast: false
reversible: true
name: GDP Releasing
type: Reaction

metaid_0000006
has part: P18825
boundary condition: false
has part: P08913
constant: false
initial concentration: 0.0
in compartment: metaid_0000003
has part: GO:0005834
initial amount: NaN
type: Species
has part: P18089
has only substance units: false
has part: CHEBI:35569
name: DRG_GDP
has part: CHEBI:17552

030506
stoichiometry: 1.0
species: metaid_0000012
type: SpeciesReference

030289
stoichiometry: 1.0
species: metaid_0000007
type: SpeciesReference

metaid_0000013
has version: P08913
constant: false
has version: P18089
has version: P18825
type: Species
boundary condition: false
in compartment: metaid_0000003
initial concentration: 1.0E-10
initial amount: NaN
name: R
has only substance units: false

metaid_0000003
is version of: GO:0005623
constant: true
size: 1.0
spatial dimensions: 3.0
name: cell
type: Compartment

030265
value: 10.0
type: LocalParameter

030229
stoichiometry: 1.0
species: metaid_0000005
type: SpeciesReference

metaid_0000017
type: Reaction
fast: false
reversible: true
reactant: 030434
name: GTP binding with DRG
product: 030446
is version of: GO:0032403
is version of: GO:0005525
reactant: 030422
kinetic law: 030458

030374
stoichiometry: 1.0
species: metaid_0000008
type: SpeciesReference

030482
value: 55.0
type: LocalParameter

metaid_0000007
in compartment: metaid_0000003
initial concentration: 1.0E-6
has part: GO:0005834
has part: CHEBI:17552
initial amount: NaN
type: Species
has only substance units: false
boundary condition: false
constant: false
name: G_GDP

030410
value: 100000.0
type: LocalParameter