982689
exponent: 1.0
scale: 0
multipler: 60.0
kind: SECOND
type: SBMLUnit

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stoichiometry: 1.0
species: metaid_0000010
type: SpeciesReference

982773
stoichiometry: 2.0
species: metaid_0000008
type: SpeciesReference

metaid_0000012
has version: GO:0005834
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.1
initial amount: NaN
in compartment: metaid_0000006
name: GQ
type: Species

982737
stoichiometry: 1.0
species: metaid_0000009
type: SpeciesReference

367362
value: 2.0E7
type: LocalParameter

metaid_0000016
kinetic law: 982845
product: 982833
reactant: 982821
reactant: 982809
is version of: GO:0007202
fast: false
reversible: true
name: G protein react with dimer producing E
type: Reaction

367356
value: 5.0
type: LocalParameter

metaid_0000023
constant: true
units: metaid_0000024
value: 4.0
name: beta
type: Parameter

982857
stoichiometry: 1.0
species: metaid_0000013
type: SpeciesReference

metaid_0000006
is: GO:0005623
constant: true
size: 1.0
spatial dimensions: 3.0
name: cell
type: Compartment

metaid_0000019
event assignment: 982929
trigger: 982917
is version of: GO:0046888
use values from trigger time: true
name: removal of hormone
type: Event

367359
value: 4000.0
type: LocalParameter

BIOMD0000000077
species: metaid_0000020
rule: metaid_0000021
units def: metaid_0000005
event: metaid_0000019
reaction: metaid_0000014
species: metaid_0000007
created:
  W3 CDTF: Thu Nov 09 17:07:08 GMT 2006
reaction: metaid_0000015
species: metaid_0000011
creator:
  ORG:
    orgname: EMBL-EBI
  n:
    given: Enuo
    family: He
is described by: http://identifiers.org/pubmed/10662710
species: metaid_0000008
area units: metaid_0000005
volume units: metaid_0000004
species: metaid_0000012
notes: A mathematical model quantifying GnRH-induced LH secretion from gonadotropes by Blum et al (2000) This paper includes three stages, and the model does not include the third stage. Also an event is included which remove the hormone GnRH at time=5min. Figure 1 and Figure 2 of the paper are reproduced, using SBML odeSolver. We choose to encode the model with the concentration of GnRH equal to 1.0nM. This model originates from BioModels Database: A Database of Annotated Published Models. It is copyright (c) 2005-2009 The BioModels Team. For more information see the terms of use . To cite BioModels Database, please use Le Novère N., Bornstein B., Broicher A., Courtot M., Donizelli M., Dharuri H., Li L., Sauro H., Schilstra M., Shapiro B., Snoep J.L., Hucka M. (2006) BioModels Database: A Free, Centralized Database of Curated, Published, Quantitative Kinetic Models of Biochemical and Cellular Systems Nucleic Acids Res., 34: D689-D691.
is: MODEL3092061764
is part of: GO:0007200
substance units: metaid_0000005
time units: metaid_0000004
type: SBMLModel
reaction: metaid_0000018
parameter: metaid_0000022
species: metaid_0000010
compartment: metaid_0000006
units def: metaid_0000004
units def: metaid_0000024
curated: true
length unit: length
occurs in: http://identifiers.org/taxonomy/131567
is part of: GO:0032275
parameter: metaid_0000023
species: metaid_0000009
reaction: metaid_0000017
reaction: metaid_0000016
species: metaid_0000013
modified:
  W3 CDTF: Fri Apr 20 20:03:22 BST 2012
name: Blum2000_LHsecretion_1

metaid_0000009
has version: P30969
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.01
initial amount: NaN
in compartment: metaid_0000006
name: R
type: Species

367360
value: 200.0
type: LocalParameter

982833
stoichiometry: 1.0
species: metaid_0000011
type: SpeciesReference

982881
stoichiometry: 1.0
species: metaid_0000013
type: SpeciesReference

metaid_0000011
is: PIRSF005483
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: metaid_0000006
name: E
type: Species

metaid_0000015
kinetic law: 982797
product: 982785
reactant: 982773
is version of: GO:0006461
fast: false
reversible: true
name: HR forming HRRH
type: Reaction

metaid_0000020
is version of: IPR000699
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: metaid_0000006
name: CHO
type: Species

367361
value: 10.0
type: LocalParameter

metaid_0000024
unit: 982713
name: unit for beta
type: SBMLUnitsDef

982713
exponent: -1.0
scale: 0
multipler: 60.0
kind: SECOND
type: SBMLUnit

982917
persistant: true
initial value: true
type: Trigger

367358
value: 5.0
type: LocalParameter

982725
stoichiometry: 1.0
species: metaid_0000007
type: SpeciesReference

metaid_0000014
is version of: GO:0051428
fast: false
product: 982749
reversible: true
type: Reaction
is version of: GO:0004968
kinetic law: 982761
reactant: 982725
reactant: 982737
is version of: GO:0005102
name: H binding to R

metaid_0000008
has only substance units: false
in compartment: metaid_0000006
initial concentration: 0.0
initial amount: NaN
boundary condition: false
constant: false
type: Species
name: HR
has version: P30969
has version: P07490

metaid_0000010
is version of: GO:0043234
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: metaid_0000006
name: HRRH
type: Species

982785
stoichiometry: 1.0
species: metaid_0000010
type: SpeciesReference

982749
stoichiometry: 1.0
species: metaid_0000008
type: SpeciesReference

367354
value: 2.5
type: LocalParameter

metaid_0000018
kinetic law: 982905
modifier: 982893
product: 982881
is version of: GO:0004629
fast: false
reversible: false
name: Production of IP3
type: Reaction

metaid_0000013
constant: false
boundary condition: false
is version of: CHEBI:16595
type: Species
is version of: C01245
initial amount: NaN
has only substance units: false
in compartment: metaid_0000006
name: IP3
initial concentration: 0.0

367357
value: 2500.0
type: LocalParameter

982701
exponent: 1.0
scale: -9
multipler: 1.0
kind: MOLE
type: SBMLUnit

metaid_0000007
initial amount: NaN
boundary condition: false
type: Species
has version: P51924
has only substance units: false
in compartment: metaid_0000006
has version: P07490
initial concentration: 1.0
name: H
constant: false

982821
stoichiometry: 1.0
species: metaid_0000012
type: SpeciesReference

metaid_0000017
kinetic law: 982869
reactant: 982857
is version of: GO:0009056
fast: false
reversible: false
name: IP3 converted into inactive metabolites
type: Reaction

metaid_0000022
constant: true
units: metaid_0000005
value: 2.0
name: alpha
type: Parameter