This model is according to the paper Toward a detailed computational model for the mammalian circadian clock . In this model only interlocked negative and positive regulation of Per, Cry, Bmal gene are involved. Some initial values were not provided, therefore they were chosen to fit the curve from the paper. Figure2A re-produced by Copasi 4.0.19 and roadRunner online. To the extent possible under law, all copyright and related or neighbouring rights to this encoded model have been dedicated to the public domain worldwide. Please refer to CC0 Public Domain Dedication for more information. In summary, you are entitled to use this encoded model in absolutely any manner you deem suitable, verbatim, or with modification, alone or embedded it in a larger context, redistribute it, commercially or not, in a restricted way or not. To cite BioModels Database, please use: Li C, Donizelli M, Rodriguez N, Dharuri H, Endler L, Chelliah V, Li L, He E, Henry A, Stefan MI, Snoep JL, Hucka M, Le Novère N, Laibe C (2010) BioModels Database: An enhanced, curated and annotated resource for published quantitative kinetic models. BMC Syst Biol., 4:92.
The initial concentration of Mb got from the curve in the paper at time=0
In order to get the similar shape of the plot,we assigned 2nM as initial concentration for Bc
Initial concentration for Mc got from the value of the curve at time=0 in the paper.
Initial concentration for Mp got from the value of curve at time=0 in the paper.
Per_Cry and Clock_Bmal form inactive complex