800692
stoichiometry: 1.0
species: metaid_0000013
type: SpeciesReference

800318
units: dimensionless
value: 3.93
type: LocalParameter

800173
units: metaid_0000024
value: 0.144
type: LocalParameter

799847
units: metaid_0000024
value: 0.97
type: LocalParameter

800040
stoichiometry: 1.0
species: metaid_0000004
type: SpeciesReference

799677
exponent: -1.0
scale: 0
multipler: 60.0
kind: SECOND
type: SBMLUnit

metaid_0000022
unit: 799569
name: millimole
type: SBMLUnitsDef

800474
stoichiometry: 1.0
species: metaid_0000007
type: SpeciesReference

799581
exponent: 1.0
scale: 0
multipler: 60.0
kind: SECOND
type: SBMLUnit

800570
units: metaid_0000024
value: 4.7
type: LocalParameter

800728
units: metaid_0000027
value: 4.1E-5
type: LocalParameter

799714
exponent: -1.0
scale: 0
multipler: 60.0
kind: SECOND
type: SBMLUnit

metaid_0000015
product: 799774
reactant: 799750
reactant: 799762
is version of: GO:0004072
fast: false
name: Aspartate Kinase
modifier: 799799
is: R00480
type: Reaction
product: 799787
is version of: http://identifiers.org/ec-code/2.7.2.4
kinetic law: 799811
reversible: true

metaid_0000009
is: CHEBI:16857
constant: false
initial concentration: 2.0
type: Species
initial amount: NaN
has only substance units: false
in compartment: metaid_0000003
is: C00188
name: Threonine
boundary condition: false

799992
units: metaid_0000024
value: 0.017
type: LocalParameter

800281
units: dimensionless
value: 3162.27766016838
type: LocalParameter

800486
stoichiometry: 1.0
species: metaid_0000013
type: SpeciesReference

800125
units: metaid_0000024
value: 0.022
type: LocalParameter

799762
stoichiometry: 1.0
species: metaid_0000010
type: SpeciesReference

800342
units: metaid_0000024
value: 3.39
type: LocalParameter

metaid_0000023
unit: 799581
name: min
type: SBMLUnitsDef

800294
units: metaid_0000024
value: 0.097
type: LocalParameter

799629
exponent: -1.0
scale: 0
multipler: 1.0
kind: LITRE
type: SBMLUnit

800269
units: metaid_0000025
value: 1.001
type: LocalParameter

metaid_0000008
has only substance units: false
name: Phos
is: C00009
constant: false
in compartment: metaid_0000003
is: CHEBI:18367
boundary condition: false
type: Species
initial concentration: 0.0
initial amount: NaN

metaid_0000014
type: Species
in compartment: metaid_0000003
initial concentration: 10.0
is: CHEBI:15422
name: ATP
is: C00002
has only substance units: false
boundary condition: false
constant: false
initial amount: NaN

799689
exponent: 1.0
scale: -3
multipler: 1.0
kind: MOLE
type: SBMLUnit

799968
units: dimensionless
value: 2.8
type: LocalParameter

metaid_0000020
kinetic law: 800643
product: 800631
reactant: 800619
is version of: GO:0006739
fast: false
reversible: true
name: Endogenous consumption of NADPH
type: Reaction

799835
units: dimensionless
value: 6.4E-4
type: LocalParameter

800161
units: metaid_0000024
value: 0.029
type: LocalParameter

799702
exponent: -1.0
scale: -3
multipler: 1.0
kind: GRAM
type: SBMLUnit

799980
units: metaid_0000024
value: 0.32
type: LocalParameter

metaid_0000003
is: GO:0005623
constant: true
size: 1.0
spatial dimensions: 3.0
type: Compartment

799593
exponent: 1.0
scale: -3
multipler: 1.0
kind: MOLE
type: SBMLUnit

metaid_0000013
constant: false
is: CHEBI:16761
is: C00008
type: Species
initial amount: NaN
name: ADP
boundary condition: false
initial concentration: 0.0
has only substance units: false
in compartment: metaid_0000003

799896
units: metaid_0000024
value: 0.017
type: LocalParameter

metaid_0000028
unit: 799738
unit: 799726
name: mg_per_litre
type: SBMLUnitsDef

800354
units: metaid_0000024
value: 0.037
type: LocalParameter

800004
units: metaid_0000024
value: 0.22
type: LocalParameter

800655
units: metaid_0000026
value: 5.4E-6
type: LocalParameter

metaid_0000021
kinetic law: 800716
product: 800704
product: 800692
reactant: 800679
is: GO:0016887
fast: false
reversible: true
name: ATPase
type: Reaction

799641
exponent: -1.0
scale: 0
multipler: 60.0
kind: SECOND
type: SBMLUnit

800221
stoichiometry: 1.0
species: metaid_0000011
type: SpeciesReference

800137
units: metaid_0000024
value: 0.11
type: LocalParameter

800522
units: metaid_0000025
value: 0.1
type: LocalParameter

799774
stoichiometry: 1.0
species: metaid_0000004
type: SpeciesReference

799617
exponent: 1.0
scale: -3
multipler: 1.0
kind: MOLE
type: SBMLUnit

metaid_0000012
in compartment: metaid_0000003
type: Species
initial amount: NaN
is: C00005
has only substance units: false
name: NADPH
boundary condition: false
initial concentration: 2.0
constant: false
is: CHEBI:16474

800740
units: metaid_0000028
value: 202.0
name: Protein
type: LocalParameter

metaid_0000026
unit: 799677
unit: 799665
unit: 799653
name: litre_per_mg_per_min
type: SBMLUnitsDef

800366
units: metaid_0000024
value: 0.067
type: LocalParameter

799883
units: dimensionless
value: 2.47
type: LocalParameter

800704
stoichiometry: 1.0
species: metaid_0000008
type: SpeciesReference

800402
stoichiometry: 1.0
species: metaid_0000008
type: SpeciesReference

metaid_0000005
name: Aspartate beta-semialdehyde
is: C00441
constant: false
is: CHEBI:18051
boundary condition: false
type: Species
initial concentration: 0.0
in compartment: metaid_0000003
initial amount: NaN
has only substance units: false

799823
units: metaid_0000025
value: 0.15
type: LocalParameter

metaid_0000011
constant: false
is: CHEBI:18009
boundary condition: false
initial amount: NaN
type: Species
initial concentration: 0.0
has only substance units: false
is: C00006
name: NADP
in compartment: metaid_0000003

800197
stoichiometry: 1.0
species: metaid_0000005
type: SpeciesReference

799956
units: metaid_0000024
value: 0.391
type: LocalParameter

800607
units: metaid_0000024
value: 4.35
type: LocalParameter

800113
units: dimensionless
value: 56.4150334574039
type: LocalParameter

800064
stoichiometry: 1.0
species: metaid_0000008
type: SpeciesReference

799750
stoichiometry: 1.0
species: metaid_0000014
type: SpeciesReference

metaid_0000019
is version of: GO:0004413
product: 800486
type: Reaction
product: 800474
reversible: true
name: Homoserine kinase
is: R01771
reactant: 800462
is version of: http://identifiers.org/ec-code/2.7.1.39
fast: false
reactant: 800450
modifier: 800498
kinetic law: 800510

799920
units: metaid_0000024
value: 0.25
type: LocalParameter

800076
stoichiometry: 1.0
species: metaid_0000005
type: SpeciesReference

800450
stoichiometry: 1.0
species: metaid_0000006
type: SpeciesReference

metaid_0000027
unit: 799714
unit: 799702
unit: 799689
name: millimole_per_mg_per_min
type: SBMLUnitsDef

799605
exponent: -1.0
scale: 0
multipler: 1.0
kind: LITRE
type: SBMLUnit

metaid_0000018
name: Threonine synthase
product: 800402
product: 800390
kinetic law: 800414
type: Reaction
fast: false
reversible: true
reactant: 800378
is version of: GO:0004795
is version of: http://identifiers.org/ec-code/4.2.3.1
is: R01466

799738
exponent: -1.0
scale: 0
multipler: 1.0
kind: LITRE
type: SBMLUnit

800438
units: metaid_0000024
value: 0.31
type: LocalParameter

metaid_0000004
boundary condition: false
initial amount: NaN
has only substance units: false
initial concentration: 0.0
constant: false
in compartment: metaid_0000003
is: C03082
type: Species
is: CHEBI:15836
name: Aspartyl phosphate

BIOMD0000000066
modified:
  W3 CDTF: Wed May 16 11:20:51 BST 2012
species: metaid_0000007
units def: metaid_0000028
reaction: metaid_0000020
reaction: metaid_0000018
compartment: metaid_0000003
reaction: metaid_0000019
area units: area
creator:
  ORG:
    orgname: Stellenbosh University
  n:
    given: Jacky L
    family: Snoep
notes: . . . SBML level 2 code generated for the JWS Online project by Jacky Snoep using PySCeS Run this model online at http://jjj.biochem.sun.ac.za To cite JWS Online please refer to: Olivier, B.G. and Snoep, J.L. (2004) Web-based modelling using JWS Online , Bioinformatics, 20:2143-2144 . . . . . . Biomodels Curation: The model reproduces Fig 2f of the paper. The Vmax values for different reactions are obtained by multiplying the specific activites given in Table 3 of the paper with the protein concentration and an assay correction factor that was provided by the authors. The protein concentration is 202 mg/litre. The specific activities that need to be taken into consideration are those given for "variable threonine" in Table 3. The following are the assay correction factors provided by the authors: vak1=1.49; vak3=1.12; vasd=1.14; vhsd=1.42; vts=1.15; vhk=1.13. The model was successfully tested on MathSBML and Jarnac
species: metaid_0000008
species: metaid_0000010
units def: metaid_0000022
creator:
  ORG:
    orgname: California Institute of Technology
  n:
    given: Harish
    family: Dharuri
species: metaid_0000011
units def: metaid_0000025
species: metaid_0000014
species: metaid_0000005
type: SBMLModel
reaction: metaid_0000016
reaction: metaid_0000017
occurs in: http://identifiers.org/taxonomy/83333
time units: metaid_0000023
reaction: metaid_0000015
species: metaid_0000009
units def: metaid_0000027
species: metaid_0000012
units def: metaid_0000024
is: MODEL6624131052
species: metaid_0000006
substance units: metaid_0000022
name: Chassagnole2001_Threonine Synthesis
curated: true
volume units: metaid_0000323
has part: GO:0006531
length unit: length
created:
  W3 CDTF: Tue Aug 29 11:11:33 BST 2006
reaction: metaid_0000021
units def: metaid_0000023
has part: GO:0009088
is version of: map00260
is described by: http://identifiers.org/pubmed/11368770
units def: metaid_0000026
species: metaid_0000013
species: metaid_0000004

800149
units: metaid_0000024
value: 10.0
type: LocalParameter

800534
units: metaid_0000024
value: 0.46
type: LocalParameter

800390
stoichiometry: 1.0
species: metaid_0000009
type: SpeciesReference

metaid_0000010
is: CHEBI:17053
initial amount: NaN
constant: false
initial concentration: 2.0
is: C00049
name: Aspartate
in compartment: metaid_0000003
has only substance units: false
boundary condition: false
type: Species

800209
stoichiometry: 1.0
species: metaid_0000006
type: SpeciesReference

800016
units: metaid_0000024
value: 0.25
type: LocalParameter

799653
exponent: 1.0
scale: 0
multipler: 1.0
kind: LITRE
type: SBMLUnit

800667
units: metaid_0000028
value: 202.0
name: Protein
type: LocalParameter

metaid_0000024
unit: 799605
unit: 799593
name: mM
type: SBMLUnitsDef

799569
exponent: 1.0
scale: -3
multipler: 1.0
kind: MOLE
type: SBMLUnit

metaid_0000017
product: 800209
reversible: true
reactant: 800197
fast: false
modifier: 800245
is version of: http://identifiers.org/ec-code/1.1.1.3
is version of: GO:0004412
product: 800221
reactant: 800185
is: R01775
type: Reaction
kinetic law: 800257
name: Homoserine dehydrogenase
modifier: 800233

metaid_0000007
has only substance units: false
is: C01102
type: Species
boundary condition: false
initial concentration: 0.0
initial amount: NaN
is: CHEBI:15961
in compartment: metaid_0000003
name: O-Phospho-homoserine
constant: false

800558
units: metaid_0000024
value: 0.072
type: LocalParameter

800378
stoichiometry: 1.0
species: metaid_0000007
type: SpeciesReference

800582
units: metaid_0000024
value: 0.11
type: LocalParameter

799871
units: dimensionless
value: 4.09
type: LocalParameter

800100
units: metaid_0000025
value: 0.1812
type: LocalParameter

799908
units: metaid_0000024
value: 0.98
type: LocalParameter

799944
units: metaid_0000024
value: 0.46
type: LocalParameter

800330
units: metaid_0000024
value: 0.24
type: LocalParameter

800631
stoichiometry: 1.0
species: metaid_0000011
type: SpeciesReference

800052
stoichiometry: 1.0
species: metaid_0000011
type: SpeciesReference

799787
stoichiometry: 1.0
species: metaid_0000013
type: SpeciesReference

800306
units: dimensionless
value: 1.41
type: LocalParameter

800619
stoichiometry: 1.0
species: metaid_0000012
type: SpeciesReference

800185
stoichiometry: 1.0
species: metaid_0000012
type: SpeciesReference

800595
units: metaid_0000024
value: 1.09
type: LocalParameter

metaid_0000025
unit: 799641
unit: 799629
unit: 799617
name: mM_per_min
type: SBMLUnitsDef

800426
units: metaid_0000025
value: 0.0434
type: LocalParameter

799726
exponent: 1.0
scale: -3
multipler: 1.0
kind: GRAM
type: SBMLUnit

metaid_0000016
is version of: http://identifiers.org/ec-code/1.2.1.11
reactant: 800028
is version of: GO:0004073
product: 800064
product: 800052
product: 800076
kinetic law: 800088
fast: false
type: Reaction
is: R02291
reversible: true
reactant: 800040
name: Aspartate semialdehyde dehydrogenase

800462
stoichiometry: 1.0
species: metaid_0000014
type: SpeciesReference

799932
units: metaid_0000025
value: 0.0722
type: LocalParameter

metaid_0000006
boundary condition: false
constant: false
name: Homoserine
initial concentration: 0.0
has only substance units: false
in compartment: metaid_0000003
type: Species
is: CHEBI:15699
is: C00263
initial amount: NaN

799665
exponent: -1.0
scale: -3
multipler: 1.0
kind: GRAM
type: SBMLUnit

800028
stoichiometry: 1.0
species: metaid_0000012
type: SpeciesReference

800679
stoichiometry: 1.0
species: metaid_0000014
type: SpeciesReference

799859
units: metaid_0000024
value: 0.167
type: LocalParameter

800546
units: metaid_0000024
value: 9.45
type: LocalParameter