674490
units: dimensionless
value: 1.92
type: LocalParameter

metaid_0000008
is: P00895
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: metaid_0000007
name: Anthranilate synthase
type: Species

metaid_0000014
kinetic law: 743149
reactant: 743137
fast: false
reversible: true
name: Enzyme dilution due to cell growth
type: Reaction

metaid_0000010
name: Total tryptophan
has only substance units: false
is: CHEBI:27897
boundary condition: false
type: Species
is: C00806
initial amount: NaN
constant: false
initial concentration: 0.0
in compartment: metaid_0000007

674498
units: metaid_0000023
value: 25.0
type: LocalParameter

674494
units: metaid_0000024
value: 25.0
type: LocalParameter

metaid_0000004
constant: true
units: metaid_0000022
value: 0.14
type: Parameter

743210
stoichiometry: 1.0
species: metaid_0000009
type: SpeciesReference

743029
exponent: 1.0
scale: -6
multipler: 1.0
kind: MOLE
type: SBMLUnit

674488
units: metaid_0000024
value: 65.0
type: LocalParameter

674500
units: metaid_0000022
value: 0.2
type: LocalParameter

metaid_0000020
kinetic law: 743246
reactant: 743234
fast: false
reversible: true
name: Tryptophan dilution due to cell growth
type: Reaction

metaid_0000024
unit: 743089
name: per_min
type: SBMLUnitsDef

743005
exponent: 1.0
scale: -6
multipler: 1.0
kind: MOLE
type: SBMLUnit

metaid_0000028
constant: false
units: dimensionless
value: NaN
name: Tt_norm
type: Parameter

metaid_0000009
type: Species
has only substance units: false
initial amount: NaN
constant: false
in compartment: metaid_0000007
boundary condition: false
initial concentration: 0.0
is: CHEBI:27897
is: C00806
name: Synthesized tryptophan

743161
stoichiometry: 1.0
species: metaid_0000009
type: SpeciesReference

743065
exponent: -1.0
scale: 0
multipler: 1.0
kind: LITRE
type: SBMLUnit

metaid_0000019
kinetic law: 743222
reactant: 743210
is version of: GO:0006412
fast: false
reversible: true
name: Tryptophan consumption for protein synthesis
type: Reaction

metaid_0000005
constant: true
units: metaid_0000022
value: 0.9
type: Parameter

metaid_0000021
unit: 743017
name: minutes
type: SBMLUnitsDef

743089
exponent: -1.0
scale: 0
multipler: 60.0
kind: SECOND
type: SBMLUnit

BIOMD0000000062
units def: metaid_0000017
units def: metaid_0000022
parameter: metaid_0000003
reaction: metaid_0000013
reaction: metaid_0000015
compartment: metaid_0000007
creator:
  ORG:
    orgname: California Institute of Technology
  n:
    given: Harish
    family: Dharuri
modified:
  W3 CDTF: Wed May 16 11:21:54 BST 2012
rule: metaid_0000033
reaction: metaid_0000020
parameter: metaid_0000026
name: Bhartiya2003_Tryptophan_operon
is described by: http://identifiers.org/pubmed/12787031
units def: metaid_0000023
substance units: metaid_0000017
units def: metaid_0000021
type: SBMLModel
curated: true
rule: metaid_0000018
time units: metaid_0000021
is version of: GO:0000162
rule: metaid_0000031
occurs in: http://identifiers.org/taxonomy/562
reaction: metaid_0000014
species: metaid_0000009
parameter: metaid_0000028
area units: area
parameter: metaid_0000004
parameter: metaid_0000027
species: metaid_0000010
creator:
  ORG:
    orgname: Stellenbosh University
  n:
    given: Jacky L
    family: Snoep
reaction: metaid_0000019
notes: SBML level 2 code originaly generated for the JWS Online project by Jacky Snoep using PySCeS Run this model online at http://jjj.biochem.sun.ac.za To cite JWS Online please refer to: Olivier, B.G. and Snoep, J.L. (2004) Web-based modelling using JWS Online , Bioinformatics, 20:2143-2144 BioModels Curation : The model reproduces Fig 3 of the publication. By substituting a value of 1.4 for Tex it is possible to reproduce Fig 3C and 3D(iii), Fig 3A and 3D(i), are obtained by setting Tex=0. Also, note that the tryptophan concentrations have been normalized by 82 micromolar in the figures; the normalized concetrations can be obtained via the parameters To/s/t_norm. The model was successfully tested on MathSBML and Copasi. This model originates from BioModels Database: A Database of Annotated Published Models. It is copyright (c) 2005-2010 The BioModels Team. For more information see the terms of use . To cite BioModels Database, please use Le Novère N., Bornstein B., Broicher A., Courtot M., Donizelli M., Dharuri H., Li L., Sauro H., Schilstra M., Shapiro B., Snoep J.L., Hucka M. (2006) BioModels Database: A Free, Centralized Database of Curated, Published, Quantitative Kinetic Models of Biochemical and Cellular Systems Nucleic Acids Res., 34: D689-D691.
rule: metaid_0000030
length unit: length
rule: metaid_0000034
volume units: metaid_0000323
is: MODEL6624111460
parameter: metaid_0000029
units def: metaid_0000024
species: metaid_0000025
rule: metaid_0000032
species: metaid_0000008
created:
  W3 CDTF: Thu Feb 04 17:43:13 GMT 2010
parameter: metaid_0000005
parameter: metaid_0000006

674489
units: metaid_0000022
value: 3.53
type: LocalParameter

metaid_0000025
constant: false
boundary condition: true
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: metaid_0000007
name: exog. Trp
type: Species

metaid_0000015
kinetic law: 743197
modifier: 743185
modifier: 743173
product: 743161
is version of: GO:0000162
fast: false
reversible: true
name: Tryptophan synthesis
type: Reaction

metaid_0000029
constant: false
units: dimensionless
value: NaN
name: Enz_norm
type: Parameter

metaid_0000026
constant: false
units: dimensionless
value: NaN
name: Ts_norm
type: Parameter

674492
units: metaid_0000024
value: 0.01
type: LocalParameter

metaid_0000006
constant: true
units: metaid_0000022
value: 380.0
type: Parameter

743041
exponent: -1.0
scale: 0
multipler: 1.0
kind: LITRE
type: SBMLUnit

674502
units: metaid_0000024
value: 0.01
type: LocalParameter

metaid_0000022
unit: 743041
unit: 743029
name: microM
type: SBMLUnitsDef

743017
exponent: 1.0
scale: 0
multipler: 60.0
kind: SECOND
type: SBMLUnit

metaid_0000013
kinetic law: 743125
modifier: 743113
product: 743101
is version of: GO:0006417
fast: false
reversible: true
name: Anthranilate synthase synthesis
type: Reaction

metaid_0000027
constant: false
units: dimensionless
value: NaN
name: To_norm
type: Parameter

743137
stoichiometry: 1.0
species: metaid_0000008
type: SpeciesReference

674491
units: metaid_0000022
value: 0.0033
type: LocalParameter

metaid_0000017
unit: 743005
name: micromole
type: SBMLUnitsDef

743053
exponent: 1.0
scale: -6
multipler: 1.0
kind: MOLE
type: SBMLUnit

metaid_0000007
is version of: GO:0005623
constant: true
size: 1.0
spatial dimensions: 3.0
name: cell
type: Compartment

metaid_0000003
constant: true
units: metaid_0000022
value: 100.0
type: Parameter

743101
stoichiometry: 1.0
species: metaid_0000008
type: SpeciesReference

metaid_0000023
unit: 743077
unit: 743065
unit: 743053
name: microM_per_min
type: SBMLUnitsDef

674496
units: metaid_0000022
value: 810.0
type: LocalParameter

743234
stoichiometry: 1.0
species: metaid_0000009
type: SpeciesReference

743077
exponent: -1.0
scale: 0
multipler: 60.0
kind: SECOND
type: SBMLUnit