metaid_0000188
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product: 332292
product: 332280
reactant: 332268
is version of: GO:0043241
fast: false
reversible: false
name: Shc_pTrkA_endo_degradation
type: Reaction

629420
value: 0.05
type: LocalParameter

metaid_0000175
is version of: GO:0051425
type: Reaction
reactant: 331691
name: binding_Shc_to_pTrkA_endo
is version of: GO:0042169
product: 331715
reactant: 331703
reversible: true
kinetic law: 331727
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629783
value: 0.8
type: LocalParameter

629484
value: 0.05
type: LocalParameter

330824
stoichiometry: 1.0
species: metaid_0000031
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629444
value: 10.0
type: LocalParameter

334060
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species: metaid_0000031
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629647
value: 4.2E-4
type: LocalParameter

metaid_0000248
kinetic law: 335249
product: 335237
product: 335225
reactant: 335213
is version of: GO:0004709
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reversible: false
type: Reaction

329873
stoichiometry: 1.0
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629464
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331596
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species: metaid_0000016
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629533
value: 10.0
type: LocalParameter

331089
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629846
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type: LocalParameter

334732
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species: metaid_0000086
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331125
stoichiometry: 1.0
species: metaid_0000069
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metaid_0000176
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reversible: true
reactant: 331739
name: binding_pShc_to_pTrkA_endo
is version of: GO:0051425
kinetic law: 331775
type: Reaction
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is version of: GO:0042169

332532
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species: metaid_0000076
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332472
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metaid_0000187
kinetic law: 332256
product: 332244
product: 332232
reactant: 332220
is version of: GO:0043241
fast: false
reversible: false
name: FRS2_pTrkA_endo_degradation
type: Reaction

629483
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type: LocalParameter

330211
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species: metaid_0000028
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metaid_0000249
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product: 335297
product: 335285
is version of: GO:0043241
product: 335273
type: Reaction
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reactant: 335261
reversible: false

331896
stoichiometry: 1.0
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328521
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335285
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328461
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331739
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629465
value: 1.0
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metaid_0000177
kinetic law: 331812
product: 331800
reactant: 331787
is version of: GO:0006468
fast: false
reversible: false
name: Shc_pTrkA_endo_phosphorylation
type: Reaction

335213
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333111
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332364
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629446
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329452
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329054
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629621
value: 6.3E-4
type: LocalParameter

334276
stoichiometry: 1.0
species: metaid_0000088
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629535
value: 0.075
type: LocalParameter

629487
value: 0.05
type: LocalParameter

330523
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metaid_0000178
kinetic law: 331848
product: 331836
reactant: 331824
is version of: GO:0006468
fast: false
reversible: false
name: Shc_pTrkA_phosphorylation
type: Reaction

629786
value: 6.25
type: LocalParameter

629423
value: 0.001
type: LocalParameter

metaid_0000189
kinetic law: 332352
product: 332340
product: 332328
reactant: 332316
is version of: GO:0043241
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reversible: false
name: pShc_pTrkA_endo_degradation
type: Reaction

333423
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629571
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629447
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type: LocalParameter

334792
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333760
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330583
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629467
value: 0.2
type: LocalParameter

629732
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type: LocalParameter

629536
value: 1.667E-4
type: LocalParameter

334120
stoichiometry: 1.0
species: metaid_0000020
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331836
stoichiometry: 1.0
species: metaid_0000075
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metaid_0000058
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boundary condition: false
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331920
stoichiometry: 1.0
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331065
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629480
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629557
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type: LocalParameter

metaid_0000184
kinetic law: 332112
product: 332100
product: 332088
reactant: 332076
is version of: GO:0043241
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reversible: false
name: pFRS2_pTrkA_degradation
type: Reaction

331101
stoichiometry: 1.0
species: metaid_0000034
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333508
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species: metaid_0000069
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metaid_0000150
type: Reaction
is version of: GO:0043161
product: 330547
name: pFRS2_dpEGFR_c_Cbl_ubiq_dissociation
product: 330523
reversible: false
kinetic law: 330559
fast: false
product: 330535
reactant: 330511

metaid_0000151
kinetic law: 330607
product: 330595
reactant: 330583
reactant: 330571
is part of: GO:0046580
fast: false
reversible: true
name: binding_RasGAP_to_pDOK
type: Reaction

metaid_0000183
kinetic law: 332064
product: 332052
product: 332040
reactant: 332028
is version of: GO:0043241
fast: false
reversible: false
name: FRS2_pTrkA_degradation
type: Reaction

629518
value: 60.0
type: LocalParameter

metaid_0000170
kinetic law: 331486
product: 331474
reactant: 331462
is version of: GO:0043241
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reversible: false
name: pTrkA_degradation
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329560
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333952
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629468
value: 1.0
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629592
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type: LocalParameter

331715
stoichiometry: 1.0
species: metaid_0000074
type: SpeciesReference

metaid_0000059
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initial amount: NaN
initial concentration: 0.0
type: Species
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has part: Q8K4S7
has part: Q9QX70
boundary condition: false

331161
stoichiometry: 1.0
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331510
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species: metaid_0000067
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328545
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metaid_0000182
kinetic law: 332016
product: 332004
reactant: 331992
is version of: GO:0006468
fast: false
reversible: false
name: FRS2_pTrkA_endo_phosphorylation
type: Reaction

metaid_0000152
kinetic law: 330655
modifier: 330643
product: 330631
reactant: 330619
is version of: GO:0006468
fast: false
reversible: false
name: SOS_Grb2_phosphorylation
type: Reaction

629517
value: 0.5
type: LocalParameter

metaid_0000171
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is version of: GO:0042169
name: binding_Shc_to_pTrkA
reactant: 331498
reactant: 331510
is version of: GO:0051425
kinetic law: 331535
reversible: true
type: Reaction
product: 331523

332496
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species: metaid_0000083
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330235
stoichiometry: 1.0
species: metaid_0000026
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629440
value: 0.2
type: LocalParameter

629622
value: 6.3E-4
type: LocalParameter

629593
value: 0.0022
type: LocalParameter

333171
stoichiometry: 1.0
species: metaid_0000017
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629559
value: 0.2
type: LocalParameter

metaid_0000186
kinetic law: 332208
product: 332196
product: 332184
reactant: 332172
is version of: GO:0043241
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reversible: false
name: pShc_pTrkA_degradation
type: Reaction

335369
stoichiometry: 1.0
species: metaid_0000021
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metaid_0000173
kinetic law: 331632
product: 331620
reactant: 331608
reactant: 331596
is version of: GO:0051425
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reversible: true
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type: Reaction

330547
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332894
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332340
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333135
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metaid_0000172
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kinetic law: 331584
is version of: GO:0042169
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product: 331571
reversible: true
type: Reaction
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reactant: 331559

629381
value: 0.03
type: LocalParameter

metaid_0000153
kinetic law: 330703
modifier: 330691
product: 330679
reactant: 330667
is version of: GO:0006468
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reversible: false
name: SOS_phosphorylation
type: Reaction

629780
value: 6.25
type: LocalParameter

629625
value: 6.3E-4
type: LocalParameter

629441
value: 0.5
type: LocalParameter

329476
stoichiometry: 1.0
species: metaid_0000023
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629539
value: 1.166E-4
type: LocalParameter

629644
value: 0.0022
type: LocalParameter

330631
stoichiometry: 1.0
species: metaid_0000018
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329668
stoichiometry: 1.0
species: metaid_0000013
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629596
value: 0.0022
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629443
value: 0.2
type: LocalParameter

metaid_0000185
kinetic law: 332160
product: 332148
product: 332136
reactant: 332124
is version of: GO:0043241
fast: false
reversible: false
name: Shc_pTrkA_degradation
type: Reaction

629481
value: 0.5
type: LocalParameter

metaid_0000174
kinetic law: 331679
product: 331667
reactant: 331656
reactant: 331644
is version of: GO:0051425
fast: false
reversible: true
name: binding_pFRS2_to_pTrkA
type: Reaction

629849
value: 0.3
type: LocalParameter

331005
stoichiometry: 1.0
species: metaid_0000042
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629762
value: 15.625
type: LocalParameter

metaid_0000154
kinetic law: 330752
product: 330740
reactant: 330727
reactant: 330715
is version of: GO:0000185
fast: false
reversible: true
name: binding_c_Raf_to_Ras_GTP
type: Reaction

629380
value: 0.02
type: LocalParameter

333784
stoichiometry: 1.0
species: metaid_0000032
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330957
stoichiometry: 1.0
species: metaid_0000071
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330451
stoichiometry: 1.0
species: metaid_0000043
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629514
value: 0.5
type: LocalParameter

metaid_0000042
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has part: P63086
constant: false
boundary condition: false
has only substance units: false
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initial amount: NaN
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334048
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species: metaid_0000024
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332724
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species: metaid_0000068
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metaid_0000240
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is version of: GO:0004709
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reversible: false
type: Reaction

330259
stoichiometry: 1.0
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629597
value: 0.0022
type: LocalParameter

330174
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species: metaid_0000028
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329584
stoichiometry: 1.0
species: metaid_0000028
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629578
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type: LocalParameter

331401
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species: metaid_0000040
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metaid_0000043
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type: Species
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boundary condition: false
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629626
value: 6.3E-4
type: LocalParameter

332052
stoichiometry: 1.0
species: metaid_0000016
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629714
value: 0.6
type: LocalParameter

metaid_0000241
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product: 334900
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reactant: 334876
is version of: GO:0004709
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reversible: false
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328594
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331944
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species: metaid_0000040
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329186
stoichiometry: 1.0
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629867
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type: LocalParameter

333844
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629579
value: 2.0
type: LocalParameter

629825
value: 0.5
type: LocalParameter

metaid_0000130
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product: 329500
reactant: 329488
reactant: 329476
is version of: GO:0042169
fast: false
reversible: true
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type: Reaction

333904
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species: metaid_0000065
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metaid_0000044
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has part: Q9QYV3
boundary condition: false
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has part: Q8K4S7

629629
value: 6.3E-4
type: LocalParameter

metaid_0000181
kinetic law: 331980
product: 331968
reactant: 331956
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is version of: GO:0051425
fast: false
reversible: true
name: binding_pFRS2_to_pTrkA_endo
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metaid_0000242
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fast: false
reversible: false
type: Reaction

629668
value: 0.2
type: LocalParameter

329307
stoichiometry: 1.0
species: metaid_0000052
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629711
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type: LocalParameter

330367
stoichiometry: 1.0
species: metaid_0000026
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629864
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type: LocalParameter

629515
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type: LocalParameter

333243
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species: metaid_0000025
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metaid_0000045
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metaid_0000180
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product: 331920
reactant: 331908
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is version of: GO:0051425
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name: binding_FRS2_to_pTrkA_endo
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331317
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629669
value: 10.0
type: LocalParameter

332148
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species: metaid_0000017
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331462
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335093
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metaid_0000243
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is version of: GO:0004709
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reversible: false
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330740
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328836
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species: metaid_0000009
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333195
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species: metaid_0000053
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335261
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331908
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335177
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333892
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329259
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629572
value: 10.0
type: LocalParameter

332424
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species: metaid_0000075
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metaid_0000244
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product: 335045
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is version of: GO:0004709
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reversible: false
type: Reaction

331872
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species: metaid_0000076
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332700
stoichiometry: 1.0
species: metaid_0000083
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629717
value: 16.304
type: LocalParameter

334984
stoichiometry: 1.0
species: metaid_0000064
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330415
stoichiometry: 1.0
species: metaid_0000044
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629488
value: 1.0
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629822
value: 0.5
type: LocalParameter

629738
value: 10.0
type: LocalParameter

331233
stoichiometry: 1.0
species: metaid_0000034
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629843
value: 0.2
type: LocalParameter

334168
stoichiometry: 1.0
species: metaid_0000058
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629574
value: 0.2
type: LocalParameter

332076
stoichiometry: 1.0
species: metaid_0000076
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334756
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species: metaid_0000065
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331968
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329981
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328412
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metaid_0000245
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is version of: GO:0004709
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329897
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species: metaid_0000055
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329295
stoichiometry: 1.0
species: metaid_0000011
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629840
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629512
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type: LocalParameter

331571
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species: metaid_0000075
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330343
stoichiometry: 1.0
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328800
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species: metaid_0000018
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629575
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629735
value: 1.0
type: LocalParameter

333315
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species: metaid_0000028
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629461
value: 0.005
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metaid_0000246
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reactant: 335117
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reversible: false
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metaid_0000020
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boundary condition: false
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629801
value: 1.2
type: LocalParameter

333928
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species: metaid_0000063
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332124
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metaid_0000041
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329380
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328812
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334252
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629511
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629861
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metaid_0000247
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is version of: GO:0004709
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629462
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type: LocalParameter

330764
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331608
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metaid_0000040
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333267
stoichiometry: 1.0
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metaid_0000021
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metaid_0000023
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328582
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335418
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335129
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metaid_0000223
type: Reaction
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product: 334012
is version of: GO:0043241
fast: false
name: B_Raf_Ras_GTP_dissociation
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modifier: 334024
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328376
stoichiometry: 1.0
species: metaid_0000005
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metaid_0000135
kinetic law: 329885
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reactant: 329861
is version of: GO:0006470
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reversible: false
name: pShc_dephosphorylation
type: Reaction

629870
value: 0.24
type: LocalParameter

332100
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334648
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629699
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332028
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metaid_0000022
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629807
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type: LocalParameter

335032
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metaid_0000222
type: Reaction
reversible: false
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product: 333940
reactant: 333928
modifier: 333964
kinetic law: 333976
name: c_Raf_Ras_GTP_dissociation
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330271
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629759
value: 2.0
type: LocalParameter

metaid_0000136
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reversible: false
name: pFRS2_dephosphorylation
type: Reaction

629609
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type: LocalParameter

335478
stoichiometry: 1.0
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333339
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328776
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629698
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332942
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334360
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metaid_0000025
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331389
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metaid_0000221
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product: 333904
product: 333892
reactant: 333880
is version of: GO:0043241
fast: false
reversible: false
name: ppMEK_ERK_dissociation
type: Reaction

328861
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species: metaid_0000027
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629804
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type: LocalParameter

629606
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type: LocalParameter

334840
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metaid_0000137
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product: 329957
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is version of: GO:0006461
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reversible: true
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629672
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type: LocalParameter

330138
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333050
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334000
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332172
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metaid_0000024
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333736
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metaid_0000110
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reactant: 328594
reactant: 328582
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reversible: true
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type: Reaction

metaid_0000220
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reactant: 333844
reactant: 333832
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fast: false
reversible: true
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629520
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629607
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type: LocalParameter

333676
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332785
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metaid_0000138
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629671
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type: LocalParameter

metaid_0000111
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type: Reaction
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reactant: 328643
kinetic law: 328667
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product: 328655

metaid_0000070
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metaid_0000027
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332833
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metaid_0000006
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629675
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330872
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metaid_0000047
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332088
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metaid_0000098
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335394
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331691
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metaid_0000131
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product: 329536
reactant: 329524
is version of: GO:0016567
fast: false
reversible: false
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type: Reaction

333375
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metaid_0000112
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product: 328691
reactant: 328679
is version of: GO:0006470
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reversible: true
name: pDOKdephosphorylation
type: Reaction

334552
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metaid_0000026
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333520
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metaid_0000007
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629674
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type: LocalParameter

332004
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metaid_0000046
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metaid_0000099
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629569
value: 10.0
type: LocalParameter

metaid_0000132
is: GO:0043161
reactant: 329560
kinetic law: 329608
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reversible: false
type: Reaction
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fast: false
product: 329572
name: Grb2_SOS_pShc_dpEGFR_c_Cbl_ubiq_degradation

332280
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metaid_0000029
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333279
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metaid_0000113
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product: 328739
name: binding_cCbl_pShc_dpEGFR
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kinetic law: 328751
reactant: 328715
is: GO:0017124
is: GO:0031625

332328
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metaid_0000072
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boundary condition: false
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metaid_0000008
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629677
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type: LocalParameter

334900
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species: metaid_0000058
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metaid_0000049
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331365
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328885
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332749
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629828
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type: LocalParameter

metaid_0000133
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product: 329644
product: 329632
reactant: 329620
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reversible: false
name: Grb2_SOS_pShc_Dissociation
type: Reaction

metaid_0000028
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metaid_0000071
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331426
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335502
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metaid_0000114
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reactant: 328763
is version of: GO:0006470
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fast: false
reversible: false
name: SOSdephosphorylation
type: Reaction

329211
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metaid_0000009
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328934
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332196
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629603
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metaid_0000048
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331353
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species: metaid_0000070
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metaid_0000134
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modifier: 329716
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product: 329680
type: Reaction
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330053
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species: metaid_0000039
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metaid_0000075
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type: Species

metaid_0000156
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product: 330836
reactant: 330824
reactant: 330812
is version of: GO:0000185
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reversible: true
name: binding_B_Raf_to_Ras_GTP
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metaid_0000203
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kinetic law: 332978
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type: Reaction
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product: 332942

629600
value: 4.2E-4
type: LocalParameter

metaid_0000093
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metaid_0000115
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reactant: 328800
is version of: GO:0006470
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fast: false
reversible: false
name: pSOS_Grb2_dephosphorylation
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629566
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type: LocalParameter

335430
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species: metaid_0000032
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metaid_0000055
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329114
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629650
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330113
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metaid_0000202
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fast: false
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kinetic law: 332918
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name: Crk_C3G_pFRS2_pTrkA_degradation

334600
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metaid_0000074
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333099
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species: metaid_0000103
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metaid_0000155
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629383
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334456
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330307
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629416
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metaid_0000094
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629565
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332906
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331763
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species: metaid_0000078
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metaid_0000116
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metaid_0000073
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328643
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metaid_0000003
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size: 1.0
spatial dimensions: 3.0
type: Compartment

metaid_0000054
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335345
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329632
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329945
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metaid_0000077
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metaid_0000201
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metaid_0000096
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629384
value: 0.03
type: LocalParameter

330077
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metaid_0000158
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type: Reaction
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name: pMEK_dephosphorylation
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334300
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metaid_0000229
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type: Reaction

334660
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metaid_0000117
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reactant: 328885
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type: Reaction

629568
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metaid_0000095
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629419
value: 0.2
type: LocalParameter

metaid_0000057
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metaid_0000004
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type: Compartment

334924
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metaid_0000076
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metaid_0000200
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330511
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metaid_0000097
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metaid_0000157
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330005
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329150
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629753
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331656
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metaid_0000118
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332652
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metaid_0000005
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329006
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metaid_0000228
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334516
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332232
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629653
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334888
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metaid_0000056
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330715
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629386
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629756
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metaid_0000207
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reversible: true
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629542
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type: LocalParameter

metaid_0000139
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reversible: true
name: binding_pFRS2_to_L_dpEGFR
type: Reaction

333568
stoichiometry: 1.0
species: metaid_0000014
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metaid_0000079
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has part: D4A244
constant: false
boundary condition: false
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type: Species

metaid_0000050
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has part: Q8K4S7
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boundary condition: false
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type: Species

332966
stoichiometry: 1.0
species: metaid_0000055
type: SpeciesReference

629437
value: 0.2
type: LocalParameter

629413
value: 0.001
type: LocalParameter

metaid_0000119
kinetic law: 328994
product: 328982
product: 328970
reactant: 328958
is: GO:0043161
fast: false
reversible: false
name: dpEGFR_cCbl_degrad
type: Reaction

metaid_0000227
kinetic law: 334240
product: 334228
reactant: 334216
reactant: 334204
is version of: GO:0019899
fast: false
reversible: true
type: Reaction

629387
value: 4.0
type: LocalParameter

331703
stoichiometry: 1.0
species: metaid_0000017
type: SpeciesReference

metaid_0000206
kinetic law: 333123
product: 333111
product: 333099
reactant: 333087
is version of: GO:0043241
fast: false
reversible: false
name: pFRS2_pTrkA_endo_degradation
type: Reaction

328328
stoichiometry: 1.0
species: metaid_0000102
type: SpeciesReference

629560
value: 10.0
type: LocalParameter

334492
stoichiometry: 1.0
species: metaid_0000024
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metaid_0000078
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has part: Q5M824
constant: false
boundary condition: false
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initial concentration: 0.0
initial amount: NaN
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type: Species

335321
stoichiometry: 1.0
species: metaid_0000021
type: SpeciesReference

metaid_0000159
kinetic law: 330993
product: 330969
name: ppMEK_ERK
fast: false
is part of: GO:0051389
type: Reaction
reversible: false
is version of: http://identifiers.org/ec-code/3.1.3.16
reactant: 330957
modifier: 330981
is version of: GO:0006470

332436
stoichiometry: 1.0
species: metaid_0000082
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335237
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species: metaid_0000071
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332388
stoichiometry: 1.0
species: metaid_0000084
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metaid_0000179
kinetic law: 331884
product: 331872
reactant: 331860
is version of: GO:0006468
fast: false
reversible: false
name: pFRS2_pTrkA_phosphorylation
type: Reaction

629540
value: 0.024
type: LocalParameter

331787
stoichiometry: 1.0
species: metaid_0000074
type: SpeciesReference

333880
stoichiometry: 1.0
species: metaid_0000071
type: SpeciesReference

metaid_0000226
kinetic law: 334192
product: 334180
reactant: 334168
reactant: 334156
is version of: GO:0019899
fast: false
reversible: true
type: Reaction

metaid_0000090
constant: false
has only substance units: false
type: Species
boundary condition: false
initial concentration: 0.0
has part: IPR003577
has part: Q01986
initial amount: NaN
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has part: Q99MC6

629412
value: 0.05
type: LocalParameter

330667
stoichiometry: 1.0
species: metaid_0000008
type: SpeciesReference

metaid_0000205
kinetic law: 333075
product: 333062
product: 333050
reactant: 333038
is version of: GO:0043241
fast: false
reversible: false
name: Grb2_SOS_pShc_pTrkA_endo_degradation
type: Reaction

334180
stoichiometry: 1.0
species: metaid_0000086
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334684
stoichiometry: 1.0
species: metaid_0000085
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metaid_0000053
type: Species
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has part: Q9QX70
boundary condition: false
has only substance units: false
constant: false
has part: Q5M824
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331498
stoichiometry: 1.0
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332616
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species: metaid_0000078
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328727
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species: metaid_0000022
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334324
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species: metaid_0000089
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metaid_0000091
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type: Species
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constant: false
has part: Q99MC6
boundary condition: false
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has part: Q01986
has part: IPR003577
has only substance units: false

629389
value: 0.001
type: LocalParameter

metaid_0000225
kinetic law: 334144
product: 334132
reactant: 334120
reactant: 334108
is version of: GO:0019899
fast: false
reversible: false
type: Reaction

334228
stoichiometry: 1.0
species: metaid_0000087
type: SpeciesReference

629543
value: 2.0
type: LocalParameter

332676
stoichiometry: 1.0
species: metaid_0000068
type: SpeciesReference

629562
value: 0.2
type: LocalParameter

329344
stoichiometry: 1.0
species: metaid_0000052
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metaid_0000204
kinetic law: 333026
product: 333014
product: 333002
reactant: 332990
is version of: GO:0043241
fast: false
reversible: false
name: Grb2_SOS_pShc_pTrkA_degradation
type: Reaction

333147
stoichiometry: 1.0
species: metaid_0000037
type: SpeciesReference

331559
stoichiometry: 1.0
species: metaid_0000067
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metaid_0000051
is version of: GO:0000502
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: metaid_0000004
name: proteasome
type: Species

metaid_0000224
type: Reaction
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name: B_Raf_Rap1_GTP_dissociation
reversible: false
product: 334072
reactant: 334048
product: 334060
fast: false
is version of: GO:0043241
kinetic law: 334096

metaid_0000052
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has part: Q9Z1I1
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type: Species
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initial amount: NaN
initial concentration: 0.0
has only substance units: false
constant: false
boundary condition: false

629438
value: 10.0
type: LocalParameter

334948
stoichiometry: 1.0
species: metaid_0000065
type: SpeciesReference

629777
value: 0.8
type: LocalParameter

629563
value: 5.0
type: LocalParameter

329680
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species: metaid_0000014
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330029
stoichiometry: 1.0
species: metaid_0000009
type: SpeciesReference

metaid_0000092
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boundary condition: false
constant: false
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has part: IPR003577
initial amount: NaN
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initial concentration: 0.0
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has only substance units: false

629458
value: 0.005
type: LocalParameter

329440
stoichiometry: 1.0
species: metaid_0000054
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metaid_0000238
kinetic law: 334768
product: 334756
product: 334744
reactant: 334732
is version of: GO:0004709
fast: false
reversible: false
type: Reaction

629582
value: 5.0
type: LocalParameter

335225
stoichiometry: 1.0
species: metaid_0000024
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332376
stoichiometry: 1.0
species: metaid_0000078
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329909
stoichiometry: 1.0
species: metaid_0000016
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629434
value: 0.2
type: LocalParameter

metaid_0000165
name: Ras_GDP_phosphorylation
modifier: 331281
type: Reaction
is version of: GO:0005085
product: 331245
fast: false
modifier: 331269
is version of: GO:0006468
kinetic law: 331293
reversible: false
modifier: 331257
reactant: 331233

332882
stoichiometry: 1.0
species: metaid_0000103
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329392
stoichiometry: 1.0
species: metaid_0000011
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629523
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type: LocalParameter

334264
stoichiometry: 1.0
species: metaid_0000042
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330535
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species: metaid_0000028
type: SpeciesReference

629499
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type: LocalParameter

629478
value: 0.5
type: LocalParameter

333411
stoichiometry: 1.0
species: metaid_0000023
type: SpeciesReference

metaid_0000239
kinetic law: 334816
product: 334804
product: 334792
reactant: 334780
is version of: GO:0004709
fast: false
reversible: false
type: Reaction

629636
value: 10.0
type: LocalParameter

334780
stoichiometry: 1.0
species: metaid_0000087
type: SpeciesReference

330595
stoichiometry: 1.0
species: metaid_0000057
type: SpeciesReference

629399
value: 0.5
type: LocalParameter

629774
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type: LocalParameter

629435
value: 10.0
type: LocalParameter

metaid_0000166
reversible: true
kinetic law: 331341
reactant: 331317
type: Reaction
fast: false
product: 331329
name: binding_NGF_to_NGFR
is version of: GO:0048406
reactant: 331305
is version of: GO:0051396

629524
value: 3.0
type: LocalParameter

629498
value: 0.001
type: LocalParameter

629720
value: 0.6
type: LocalParameter

629549
value: 1.0
type: LocalParameter

334072
stoichiometry: 1.0
species: metaid_0000019
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330836
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species: metaid_0000064
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328424
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species: metaid_0000007
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metaid_0000236
kinetic law: 334672
product: 334660
reactant: 334648
reactant: 334636
is version of: GO:0019899
fast: false
reversible: true
type: Reaction

329861
stoichiometry: 1.0
species: metaid_0000038
type: SpeciesReference

629635
value: 0.2
type: LocalParameter

metaid_0000163
kinetic law: 331149
product: 331137
reactant: 331125
is version of: GO:0006470
is version of: http://identifiers.org/ec-code/3.1.3.16
fast: false
reversible: false
name: Rap1_GTP_dephosphorylation
type: Reaction

629521
value: 3.0
type: LocalParameter

331523
stoichiometry: 1.0
species: metaid_0000073
type: SpeciesReference

331137
stoichiometry: 1.0
species: metaid_0000019
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332508
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species: metaid_0000081
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329500
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331800
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629834
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type: LocalParameter

329356
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species: metaid_0000054
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330295
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species: metaid_0000059
type: SpeciesReference

330223
stoichiometry: 1.0
species: metaid_0000039
type: SpeciesReference

334408
stoichiometry: 1.0
species: metaid_0000041
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metaid_0000237
kinetic law: 334720
product: 334708
product: 334696
reactant: 334684
is version of: GO:0004709
fast: false
reversible: false
type: Reaction

629457
value: 0.1
type: LocalParameter

metaid_0000164
is version of: GO:0006468
reactant: 331161
is version of: GO:0005085
product: 331173
fast: false
modifier: 331209
modifier: 331197
reversible: false
type: Reaction
modifier: 331185
name: Rap1_GTP_phosphorylation
kinetic law: 331221

metaid_0000199
kinetic law: 332761
product: 332749
reactant: 332736
reactant: 332724
is version of: GO:0042169
fast: false
reversible: true
name: binding_Crk_C3G_to_pFRS2_pTrkA_endo
type: Reaction

629495
value: 0.05
type: LocalParameter

331992
stoichiometry: 1.0
species: metaid_0000079
type: SpeciesReference

332604
stoichiometry: 1.0
species: metaid_0000075
type: SpeciesReference

629771
value: 2.0
type: LocalParameter

629509
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type: LocalParameter

629477
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type: LocalParameter

328473
stoichiometry: 1.0
species: metaid_0000011
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335297
stoichiometry: 1.0
species: metaid_0000068
type: SpeciesReference

328631
stoichiometry: 1.0
species: metaid_0000009
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629494
value: 0.2
type: LocalParameter

metaid_0000198
kinetic law: 332712
product: 332700
reactant: 332688
reactant: 332676
is version of: GO:0042169
fast: false
reversible: true
name: binding_Crk_C3G_to_pFRS2_pTrkA
type: Reaction

metaid_0000208
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fast: false
kinetic law: 333207
reactant: 333171
name: binding_Shc_to_dpEGFR_c_Cbl
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type: Reaction
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reversible: true
is version of: GO:0042169

333183
stoichiometry: 1.0
species: metaid_0000023
type: SpeciesReference

629633
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type: LocalParameter

328958
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species: metaid_0000050
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629454
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type: LocalParameter

629395
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type: LocalParameter

331329
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species: metaid_0000070
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629527
value: 3.0
type: LocalParameter

329066
stoichiometry: 1.0
species: metaid_0000049
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metaid_0000160
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is version of: GO:0006470
product: 331017
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type: Reaction
kinetic law: 331041
is part of: GO:0051389
modifier: 331029
is version of: http://identifiers.org/ec-code/3.1.3.16

metaid_0000141
kinetic law: 330150
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reactant: 330126
reactant: 330113
is version of: GO:0042169
fast: false
reversible: true
name: binding_Crk_C3G_to_pFRS2_pRTK
type: Reaction

629508
value: 25.641
type: LocalParameter

629548
value: 6.4E-5
type: LocalParameter

metaid_0000197
kinetic law: 332664
product: 332652
reactant: 332640
is version of: GO:0016567
fast: false
reversible: false
name: Shc_pTrkA_ubiquitination
type: Reaction

metaid_0000209
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reactant: 333219
name: binding_pShc_to_dpEGFR_c_Cbl
type: Reaction
kinetic law: 333255
is version of: GO:0051425
reactant: 333231
is version of: GO:0042169
product: 333243
fast: false

metaid_0000162
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is part of: GO:0046580
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kinetic law: 331113
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reversible: false
reactant: 331089
is version of: http://identifiers.org/ec-code/3.1.3.16
product: 331101

629431
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type: LocalParameter

334204
stoichiometry: 1.0
species: metaid_0000063
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334348
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species: metaid_0000064
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629632
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type: LocalParameter

629612
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type: LocalParameter

333435
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species: metaid_0000026
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330571
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333796
stoichiometry: 1.0
species: metaid_0000058
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metaid_0000161
kinetic law: 331077
product: 331065
reactant: 331053
is version of: GO:0005154
fast: false
reversible: true
name: ppERK_dimerization
type: Reaction

629750
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type: LocalParameter

629837
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type: LocalParameter

metaid_0000142
kinetic law: 330199
product: 330186
reactant: 330174
reactant: 330162
is version of: GO:0031625
fast: false
reversible: true
name: binding_c_Cbl_to_FRS2_dpEGFR
type: Reaction

331053
stoichiometry: 2.0
species: metaid_0000066
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332268
stoichiometry: 1.0
species: metaid_0000074
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metaid_0000196
kinetic law: 332628
product: 332616
reactant: 332604
is version of: GO:0016567
fast: false
reversible: false
name: pShc_pTrkA_ubiquitination
type: Reaction

333856
stoichiometry: 1.0
species: metaid_0000071
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629858
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type: LocalParameter

629545
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type: LocalParameter

329524
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species: metaid_0000048
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629398
value: 1.0E-5
type: LocalParameter

331824
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species: metaid_0000073
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328448
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species: metaid_0000008
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333940
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629451
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type: LocalParameter

335490
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species: metaid_0000032
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629506
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type: LocalParameter

629491
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type: LocalParameter

335141
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species: metaid_0000065
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331173
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species: metaid_0000069
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metaid_0000195
kinetic law: 332592
product: 332580
reactant: 332568
is version of: GO:0016567
fast: false
reversible: false
name: FRS2_pTrkA_ubiquitination
type: Reaction

629546
value: 6.2
type: LocalParameter

629630
value: 1.0
type: LocalParameter

332568
stoichiometry: 1.0
species: metaid_0000077
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328497
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species: metaid_0000012
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629396
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type: LocalParameter

metaid_0000194
kinetic law: 332556
product: 332544
reactant: 332532
is version of: GO:0016567
fast: false
reversible: false
name: pFRS2_pTrkA_ubiquitination
type: Reaction

629505
value: 0.01
type: LocalParameter

metaid_0000140
kinetic law: 330101
product: 330089
reactant: 330077
is version of: GO:0004716
fast: false
reversible: false
name: FRS2_dpEGFRphsphorylation
type: Reaction

332544
stoichiometry: 1.0
species: metaid_0000080
type: SpeciesReference

629526
value: 15.657
type: LocalParameter

metaid_0000193
kinetic law: 332520
product: 332508
reactant: 332496
is version of: GO:0016567
fast: false
reversible: false
name: Crk_C3G_pFRS2_pTrkA_ubiquitination
type: Reaction

335081
stoichiometry: 1.0
species: metaid_0000024
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metaid_0000032
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boundary condition: false
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initial amount: NaN
in compartment: metaid_0000004
type: Species

330379
stoichiometry: 1.0
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629813
value: 1.2
type: LocalParameter

333014
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species: metaid_0000052
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629852
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type: LocalParameter

328849
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species: metaid_0000017
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331017
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629656
value: 4.2E-4
type: LocalParameter

metaid_0000230
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product: 334372
reactant: 334360
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is version of: GO:0019899
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reversible: true
type: Reaction

330908
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species: metaid_0000058
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333231
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metaid_0000033
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type: Species

331305
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metaid_0000192
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reactant: 332460
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reversible: false
name: Grb2_SOS_pShc_pTrkA_ubiquitination
type: Reaction

629450
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type: LocalParameter

629792
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type: LocalParameter

629470
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type: LocalParameter

333291
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species: metaid_0000048
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metaid_0000231
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reversible: true
type: Reaction

629615
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type: LocalParameter

334972
stoichiometry: 1.0
species: metaid_0000091
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metaid_0000030
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boundary condition: false
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629729
value: 0.15
type: LocalParameter

metaid_0000191
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product: 332436
reactant: 332424
reactant: 332412
is version of: GO:0005070
fast: false
reversible: true
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331860
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332736
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334708
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330969
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629529
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type: LocalParameter

629589
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type: LocalParameter

330463
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629502
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type: LocalParameter

335165
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329223
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330162
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metaid_0000031
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metaid_0000190
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reactant: 332376
reactant: 332364
is version of: GO:0005070
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name: binding_Grb2_SOS_to_pShc_pTrkA_endo
type: Reaction

328558
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333832
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329993
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329572
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629702
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329198
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629855
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334132
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332040
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629723
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type: LocalParameter

329283
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metaid_0000254
unit: 328316
name: microMole
type: SBMLUnitsDef

metaid_0000234
kinetic law: 334576
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reactant: 334540
is version of: GO:0019899
fast: false
reversible: true
type: Reaction

333038
stoichiometry: 1.0
species: metaid_0000084
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629798
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type: LocalParameter

629588
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331474
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332136
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328763
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metaid_0000235
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is version of: GO:0019899
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reversible: true
type: Reaction

629474
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type: LocalParameter

330776
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629585
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330186
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329247
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335273
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metaid_0000252
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is part of: GO:0000188
is part of: GO:0043241
type: Reaction
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kinetic law: 335454
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reversible: false

629678
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335189
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332412
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629639
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332460
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metaid_0000232
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is version of: GO:0019899
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type: Reaction

334996
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629705
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type: LocalParameter

629471
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334156
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629586
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type: LocalParameter

331956
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334744
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328691
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331245
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330427
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333988
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629726
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metaid_0000253
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metaid_0000233
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is version of: GO:0019899
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reversible: true
type: Reaction

629638
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type: LocalParameter

629659
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type: LocalParameter

329596
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629795
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629789
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334804
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330391
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329428
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329030
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metaid_0000013
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629689
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type: LocalParameter

metaid_0000251
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331620
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metaid_0000125
kinetic law: 329271
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reactant: 329247
is version of: GO:0006468
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name: Shc_dpEGFR_c_Cblphosphorylation
type: Reaction

metaid_0000060
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332316
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334012
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330041
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333219
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332184
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328715
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330126
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metaid_0000012
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330921
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metaid_0000126
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is version of: GO:0005070
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type: Reaction

332797
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metaid_0000250
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334696
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333002
stoichiometry: 1.0
species: metaid_0000103
type: SpeciesReference

W3 CDTF: Wed May 16 15:23:03 BST 2012

331438
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333688
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334420
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333471
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333387
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328388
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metaid_0000211
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335382
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629873
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metaid_0000011
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334636
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species: metaid_0000024
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W3 CDTF: Wed Dec 21 10:59:39 GMT 2005

metaid_0000123
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is version of: GO:0016567
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332869
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metaid_0000039
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629409
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metaid_0000210
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reactant: 333279
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335020
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metaid_0000010
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629686
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333327
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330331
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334108
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332954
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metaid_0000124
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629747
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type: LocalParameter

629408
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type: LocalParameter

metaid_0000038
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330788
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330619
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629665
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334852
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metaid_0000017
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metaid_0000084
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332640
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metaid_0000101
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metaid_0000121
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is version of: GO:0016567
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metaid_0000085
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629816
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334828
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329404
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328606
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334372
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metaid_0000037
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629683
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metaid_0000016
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metaid_0000102
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metaid_0000083
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333748
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metaid_0000122
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kinetic law: 329138
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328982
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629684
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metaid_0000036
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330487
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328922
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332580
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331751
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332845
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332990
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333363
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335117
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328509
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334612
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629876
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type: LocalParameter

629662
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metaid_0000100
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334540
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335466
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332292
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629819
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type: LocalParameter

metaid_0000120
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kinetic law: 329042
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reactant: 329018
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332930
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species: metaid_0000081
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metaid_0000034
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330089
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331667
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334312
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metaid_0000146
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is version of: GO:0006468
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329933
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629390
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329620
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335045
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metaid_0000089
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335069
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metaid_0000069
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type: Species

metaid_0000105
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name: EGFbinding
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is part of: GO:0045741
reactant: 328376
kinetic law: 328400

330679
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629556
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type: LocalParameter

metaid_0000217
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reversible: false
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is version of: GO:0043241
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product: 333688
type: Reaction
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reactant: 333676
name: Grb1_SOS_pShc_dissociation

629680
value: 0.2
type: LocalParameter

BIOMD0000000049
reaction: metaid_0000252
species: metaid_0000016
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species: metaid_0000067

629402
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type: LocalParameter

329162
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type: SpeciesReference

629741
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type: LocalParameter

metaid_0000145
kinetic law: 330319
product: 330307
reactant: 330295
is version of: GO:0016567
fast: false
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name: FRS2_dpEGFR_c_Cbl_ubiquitination
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metaid_0000088
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334396
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334936
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629641
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332244
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329018
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334876
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metaid_0000068
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metaid_0000106
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is version of: GO:0005154
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type: Reaction

metaid_0000216
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reactant: 333556
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is version of: GO:0006468
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334504
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metaid_0000144
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is version of: GO:0016567
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333808
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629370
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629401
value: 0.2
type: LocalParameter

metaid_0000087
type: Species
initial concentration: 0.0
has part: P63086
in compartment: metaid_0000004
boundary condition: false
initial amount: NaN
constant: false
has part: IPR003577
has part: Q01986
has part: P11345
has only substance units: false

629392
value: 0.2
type: LocalParameter

metaid_0000067
is version of: P35739
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: metaid_0000003
type: Species

333556
stoichiometry: 1.0
species: metaid_0000013
type: SpeciesReference

metaid_0000103
constant: false
boundary condition: true
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: metaid_0000004
type: Species

metaid_0000019
has part: Q62636
has part: CHEBI:17552
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.2
initial amount: NaN
in compartment: metaid_0000004
type: Species

334564
stoichiometry: 1.0
species: metaid_0000094
type: SpeciesReference

metaid_0000219
kinetic law: 333820
product: 333808
reactant: 333796
reactant: 333784
is part of: GO:0000187
fast: false
reversible: true
name: binding_ERK_to_pMEK
type: Reaction

335442
stoichiometry: 1.0
species: metaid_0000021
type: SpeciesReference

629768
value: 15.625
type: LocalParameter

333459
stoichiometry: 1.0
species: metaid_0000061
type: SpeciesReference

328340
stoichiometry: 1.0
species: metaid_0000005
type: SpeciesReference

328898
stoichiometry: 1.0
species: metaid_0000022
type: SpeciesReference

629371
value: 1.0E-4
type: LocalParameter

metaid_0000143
kinetic law: 330247
product: 330235
reactant: 330223
reactant: 330211
is version of: GO:0031625
fast: false
reversible: true
name: binding_c_Cbl_to_pFRS2_dpEGFR
type: Reaction

334468
stoichiometry: 1.0
species: metaid_0000092
type: SpeciesReference

329488
stoichiometry: 1.0
species: metaid_0000052
type: SpeciesReference

329126
stoichiometry: 1.0
species: metaid_0000017
type: SpeciesReference

629393
value: 10.0
type: LocalParameter

metaid_0000086
initial concentration: 0.0
initial amount: NaN
constant: false
has only substance units: false
boundary condition: false
has part: IPR003577
has part: P36506
has part: P11345
type: Species
in compartment: metaid_0000004

333087
stoichiometry: 1.0
species: metaid_0000080
type: SpeciesReference

330860
stoichiometry: 1.0
species: metaid_0000065
type: SpeciesReference

metaid_0000066
is version of: P63086
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: metaid_0000004
type: Species

metaid_0000018
has part: P62994
has part: Q9Z1I1
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: metaid_0000004
type: Species

629428
value: 1.0
type: LocalParameter

328655
stoichiometry: 1.0
species: metaid_0000022
type: SpeciesReference

metaid_0000218
kinetic law: 333772
product: 333760
reactant: 333748
reactant: 333736
is part of: GO:0000187
fast: false
reversible: true
name: binding_MEK_to_ERK
type: Reaction

332821
stoichiometry: 1.0
species: metaid_0000052
type: SpeciesReference

metaid_0000104
kinetic law: 328352
product: 328340
reactant: 328328
is part of: GO:0045741
fast: false
reversible: true
name: form_EGFreceptor
type: Reaction

629553
value: 4.2E-4
type: LocalParameter

332773
stoichiometry: 1.0
species: metaid_0000052
type: SpeciesReference

metaid_0000129
type: Reaction
kinetic law: 329464
reversible: true
reactant: 329440
name: binding_c_Cbl_Grb2_SOS_pShc_dpEGFR
product: 329452
is: GO:0031625
is: GO:0017124
reactant: 329428
fast: false

329331
stoichiometry: 1.0
species: metaid_0000009
type: SpeciesReference

629532
value: 15.657
type: LocalParameter

333700
stoichiometry: 1.0
species: metaid_0000018
type: SpeciesReference

629377
value: 0.0029666
type: LocalParameter

629552
value: 6.3E-4
type: LocalParameter

metaid_0000109
kinetic law: 328570
product: 328558
reactant: 328545
is version of: GO:0004716
fast: false
reversible: true
name: EGFRphosphorylation
type: Reaction

334216
stoichiometry: 1.0
species: metaid_0000041
type: SpeciesReference

629427
value: 0.001
type: LocalParameter

329644
stoichiometry: 1.0
species: metaid_0000011
type: SpeciesReference

333062
stoichiometry: 1.0
species: metaid_0000052
type: SpeciesReference

metaid_0000213
kinetic law: 333447
product: 333435
reactant: 333423
reactant: 333411
is version of: GO:0051425
fast: false
reversible: true
name: binding_pFRS2_to_dpEGFR_c_Cbl
type: Reaction

metaid_0000065
is version of: Q01986
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: metaid_0000004
type: Species

328739
stoichiometry: 1.0
species: metaid_0000025
type: SpeciesReference

329957
stoichiometry: 1.0
species: metaid_0000068
type: SpeciesReference

metaid_0000149
reactant: 330451
reversible: false
kinetic law: 330499
product: 330475
name: FRS2_dpEGFR_c_Cbl_ubiq_dissociation
type: Reaction
is version of: GO:0043161
fast: false
product: 330463
product: 330487

332220
stoichiometry: 1.0
species: metaid_0000079
type: SpeciesReference

629406
value: 10.0
type: LocalParameter

331547
stoichiometry: 1.0
species: metaid_0000038
type: SpeciesReference

332688
stoichiometry: 1.0
species: metaid_0000076
type: SpeciesReference

330812
stoichiometry: 1.0
species: metaid_0000061
type: SpeciesReference

629765
value: 2.0
type: LocalParameter

329090
stoichiometry: 1.0
species: metaid_0000049
type: SpeciesReference

629378
value: 10.0
type: LocalParameter

metaid_0000169
kinetic law: 331450
product: 331438
reactant: 331426
is version of: GO:0043241
fast: false
reversible: false
name: pTrkA_endo_degradation
type: Reaction

331644
stoichiometry: 1.0
species: metaid_0000055
type: SpeciesReference

metaid_0000212
kinetic law: 333399
product: 333387
reactant: 333375
reactant: 333363
is version of: GO:0051425
fast: false
reversible: true
name: binding_FRS2_to_dpEGFR_c_Cbl
type: Reaction

metaid_0000064
has part: IPR003577
has part: P28028
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: metaid_0000004
type: Species

metaid_0000062
in compartment: metaid_0000004
has part: Q8K4S7
constant: false
type: Species
initial amount: NaN
has part: Q9QYV3
has only substance units: false
initial concentration: 0.0
boundary condition: false
has part: Q9QX70
has part: Q63768
has part: D4A244

metaid_0000148
kinetic law: 330439
product: 330427
reactant: 330415
is version of: GO:0016567
fast: false
reversible: false
name: Crk_C3G_pFRS2_dpEGFR_c_Cbl_ubiquitination
type: Reaction

330727
stoichiometry: 1.0
species: metaid_0000061
type: SpeciesReference

629405
value: 0.002
type: LocalParameter

629374
value: 2.2833
type: LocalParameter

629530
value: 3.0
type: LocalParameter

metaid_0000127
kinetic law: 329368
product: 329356
reactant: 329344
reactant: 329331
is version of: GO:0042169
fast: false
reversible: true
name: binding_Grb2_SOS_pShc_dpEGFR
type: Reaction

334588
stoichiometry: 1.0
species: metaid_0000024
type: SpeciesReference

629744
value: 2.0
type: LocalParameter

metaid_0000215
name: RAP1_GTP_dephosphorylation
kinetic law: 333544
reversible: false
type: Reaction
is version of: http://identifiers.org/ec-code/3.1.3.16
fast: false
reactant: 333508
product: 333520
is version of: GO:0006470
modifier: 333532

metaid_0000168
kinetic law: 331414
product: 331401
reactant: 331389
is version of: GO:0031623
fast: false
reversible: false
name: pTrkA_intermalization
type: Reaction

metaid_0000107
name: binding_SOS_Grb2
is version of: GO:0005068
fast: false
reactant: 328448
reactant: 328461
type: Reaction
is version of: GO:0005070
product: 328473
kinetic law: 328485
is version of: GO:0017124
reversible: true

metaid_0000063
has part: IPR003577
has part: P11345
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: metaid_0000004
type: Species

metaid_0000061
is: IPR003577
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: metaid_0000004
type: Species

335333
stoichiometry: 1.0
species: metaid_0000072
type: SpeciesReference

328316
exponent: 1.0
scale: -6
multipler: 1.0
kind: MOLE
type: SBMLUnit

metaid_0000147
kinetic law: 330403
product: 330391
reactant: 330379
reactant: 330367
is version of: GO:0042169
fast: false
reversible: true
name: binding_Crk_C3G_to_pFRS2_pFRS2_dpEGFR_c_Cbl
type: Reaction

metaid_0000128
kinetic law: 329416
product: 329404
reactant: 329392
reactant: 329380
is version of: GO:0005070
fast: false
reversible: true
name: binding_Grb2_SOS_pShc_dpEGFR
type: Reaction

328679
stoichiometry: 1.0
species: metaid_0000014
type: SpeciesReference

328364
stoichiometry: 1.0
species: metaid_0000101
type: SpeciesReference

629424
value: 0.05
type: LocalParameter

metaid_0000108
product: 328521
reactant: 328509
is version of: GO:0017124
is version of: GO:0005070
name: binding_pSOS_Grb2
fast: false
is version of: GO:0005068
kinetic law: 328533
reactant: 328497
type: Reaction
reversible: true

metaid_0000214
reversible: false
name: Ras_GTP_dephosphorylation
modifier: 333484
fast: false
is version of: GO:0006470
reactant: 333459
kinetic law: 333496
product: 333471
type: Reaction
is version of: http://identifiers.org/ec-code/3.1.3.16

334444
stoichiometry: 1.0
species: metaid_0000064
type: SpeciesReference

metaid_0000167
kinetic law: 331377
product: 331365
reactant: 331353
is version of: GO:0006468
is version of: GO:0004716
fast: false
reversible: false
name: TrkA_phosphorylation
type: Reaction

329102
stoichiometry: 1.0
species: metaid_0000051
type: SpeciesReference

329536
stoichiometry: 1.0
species: metaid_0000047
type: SpeciesReference

ORG:
  orgname: Tokyo University
n:
  given: Shinya
  family: Kuroda

orgname: EMBL-EBI

given: Lu
family: Li