metaid_0000007
is version of: GO:0005615
is: SBO:0000290
constant: true
size: 1.0
spatial dimensions: 3.0
type: Compartment

968586
is: SBO:0000048
value: 2.5
type: LocalParameter

968592
is: SBO:0000498
value: 0.1
type: LocalParameter

968576
is: SBO:0000162
value: 1.0
type: LocalParameter

metaid_0000020
is version of: GO:0051481
is: SBO:0000185
fast: false
reversible: false
type: Reaction

http://identifiers.org/biomodels.db/BIOMD0000000044#_844085cc_10ec_4bf3_afd3_5ce889a78a9d
exponent: 1.0
scale: 0
multipler: 60.0
kind: SECOND
type: SBMLUnit

968581
is: SBO:0000424
value: 0.2
type: LocalParameter

968577
is: SBO:0000186
value: 6.5
type: LocalParameter

http://identifiers.org/biomodels.db/BIOMD0000000044#_67774250_bd6c_452b_892c_2f508e1896cd
stoichiometry: 1.0
species: metaid_0000009
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000044#_143d4cd8_9097_4f6a_838b_04a377f6fb9e
stoichiometry: 1.0
species: metaid_0000011
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000044#_06ee764c_b812_45d5_b937_53eda70f0f4d
stoichiometry: 1.0
species: metaid_0000010
type: SpeciesReference

metaid_0000017
is version of: GO:0051481
is: SBO:0000185
fast: false
reversible: false
type: Reaction

metaid_0000003
name: micromole (default)
type: SBMLUnitsDef

http://identifiers.org/biomodels.db/BIOMD0000000044#_849b7746_2e1a_4bfb_9440_2f790ed62491
stoichiometry: 1.0
species: metaid_0000008
type: SpeciesReference

metaid_0000006
is version of: GO:0005829
is: SBO:0000290
constant: true
size: 1.0
spatial dimensions: 3.0
type: Compartment

http://identifiers.org/biomodels.db/BIOMD0000000044#bd598d9a_7fee_4183_8c5a_6a70ddcc21a2
stoichiometry: 1.0
species: metaid_0000011
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000044#_70a3f13b_355b_436b_a5fa_c16d6c3385eb
stoichiometry: 1.0
species: metaid_0000009
type: SpeciesReference

metaid_0000021
is version of: GO:0007200
is version of: GO:0006021
is: SBO:0000393
fast: false
reversible: false
name: Agonist stimulated production of IP3
type: Reaction

968575
is: SBO:0000485
value: 2.0
type: LocalParameter

968591
is: SBO:0000190
value: 4.0
type: LocalParameter

968582
is: SBO:0000423
value: 0.3
type: LocalParameter

metaid_0000016
is version of: GO:0006816
fast: false
type: Reaction
is: SBO:0000185
is version of: GO:0007204
reversible: false

http://identifiers.org/biomodels.db/BIOMD0000000044#ac378bc4_ee6b_40de_a1c2_3cffa06157e2
stoichiometry: 1.0
species: metaid_0000011
type: SpeciesReference

metaid_0000022
is version of: GO:0019310
is: SBO:0000179
fast: false
reversible: false
name: Ca dependent IP3 degradation
type: Reaction

http://identifiers.org/biomodels.db/BIOMD0000000044#b3d31ee0_175e_4021_b036_d233322ecb1d
stoichiometry: 1.0
species: metaid_0000008
type: SpeciesReference

968590
is: SBO:0000194
value: 0.4
type: LocalParameter

968584
is: SBO:0000035
value: 10.0
type: LocalParameter

http://identifiers.org/biomodels.db/BIOMD0000000044#_080a9679_dd76_4ab0_a157_a3e7f16c643d
stoichiometry: 1.0
species: metaid_0000010
type: SpeciesReference

metaid_0000019
is version of: GO:0007204
is: SBO:0000185
fast: false
reversible: false
type: Reaction

metaid_0000015
is: SBO:0000498
constant: true
value: 0.5
type: Parameter

968579
is: SBO:0000186
value: 19.5
type: LocalParameter

metaid_0000005
is version of: GO:0005790
is: SBO:0000290
constant: true
size: 1.0
spatial dimensions: 3.0
type: Compartment

metaid_0000011
in compartment: metaid_0000005
is: C00076
is: SBO:0000327
initial concentration: 0.36
has only substance units: false
initial amount: NaN
boundary condition: false
constant: false
is: CHEBI:29108
type: Species

http://identifiers.org/biomodels.db/BIOMD0000000044#a2cd746b_9874_48fa_a0e8_fbff30051500
stoichiometry: 1.0
species: metaid_0000009
type: SpeciesReference

metaid_0000009
is: CHEBI:29108
type: Species
in compartment: metaid_0000006
is: C00076
has only substance units: false
is: SBO:0000327
constant: false
initial amount: NaN
initial concentration: 0.0
boundary condition: false

http://identifiers.org/biomodels.db/BIOMD0000000044#c484780e_569a_4fe2_a0d0_3932c2d10953
stoichiometry: 1.0
species: metaid_0000009
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000044#caae2b17_bd25_4b5b_baf8_049548b5e054
exponent: 1.0
scale: -6
multipler: 1.0
kind: MOLE
type: SBMLUnit

metaid_0000023
is version of: GO:0019310
is: SBO:0000179
fast: false
reversible: false
name: Ca independent IP3 degradation
type: Reaction

BIOMD0000000044
is: MODEL6622948601
species: metaid_0000009
is part of: rno04020
reaction: metaid_0000020
units def: metaid_0000003
notes: Borghans1997 - Calcium Oscillation - Model 2 A theoretical expoloration of possible mechanisms of intracellular calcium oscillations has been studied, considering three hypothesis (see below). This model corresponds to the second hypothesis. This model is described in the article: Complex intracellular calcium oscillations. A theoretical exploration of possible mechanisms. Borghans JM, Dupont G, Goldbeter A. Biophys. Chem. 1997 May; 66(1): 25-41 Abstract: Intracellular Ca(2+) oscillations are commonly observed in a large number of cell types in response to stimulation by an extracellular agonist. In most cell types the mechanism of regular spiking is well understood and models based on Ca(2+)-induced Ca(2+) release (CICR) can account for many experimental observations. However, cells do not always exhibit simple Ca(2+) oscillations. In response to given agonists, some cells show more complex behaviour in the form of bursting, i.e. trains of Ca(2+) spikes separated by silent phases. Here we develop several theoretical models, based on physiologically plausible assumptions, that could account for complex intracellular Ca(2+) oscillations. The models are all based on one- or two-pool models based on CICR. We extend these models by (i) considering the inhibition of the Ca(2+)-release channel on a unique intracellular store at high cytosolic Ca(2+) concentrations, (ii) taking into account the Ca(2+)-activated degradation of inositol 1,4,5-trisphosphate (IP(3)), or (iii) considering explicity the evolution of the Ca(2+) concentration in two different pools, one sensitive and the other one insensitive to IP(3). Besides simple periodic oscillations, these three models can all account for more complex oscillatory behaviour in the form of bursting. Moreover, the model that takes the kinetics of IP(3) into account shows chaotic behaviour. This model is hosted on BioModels Database and identified by: MODEL6622948601 . To cite BioModels Database, please use: BioModels Database: …
substance units: metaid_0000003
reaction: metaid_0000023
is version of: GO:0048016
length unit: length
area units: area
reaction: metaid_0000022
compartment: metaid_0000005
reaction: metaid_0000019
time units: metaid_0000004
parameter: metaid_0000015
reaction: metaid_0000018
volume units: metaid_0000323
curated: true
compartment: metaid_0000007
created:
  W3 CDTF: Fri Jul 08 14:06:45 BST 2005
type: SBMLModel
species: metaid_0000008
is described by: http://identifiers.org/pubmed/17029867
name: Borghans1997 - Calcium Oscillation - Model 2
compartment: metaid_0000006
reaction: metaid_0000017
modified:
  W3 CDTF: Mon Jun 03 17:03:27 BST 2013
units def: metaid_0000004
creator:
  ORG:
    orgname: Keck Graduate Institute
  n:
    given: Harish
    family: Dharuri
species: metaid_0000011
is version of: GO:0019722
reaction: metaid_0000021
reaction: metaid_0000016
species: metaid_0000010
occurs in: http://identifiers.org/taxonomy/10114

968587
is: SBO:0000324
value: 80.0
type: LocalParameter

968583
is: SBO:0000035
value: 1.0
type: LocalParameter

metaid_0000018
is version of: GO:0051482
reversible: false
fast: false
is version of: GO:0006816
type: Reaction
is: SBO:0000185

metaid_0000010
in compartment: metaid_0000006
boundary condition: false
constant: false
is: CHEBI:16595
type: Species
is: C01245
initial amount: NaN
has only substance units: false
is: SBO:0000327
initial concentration: 0.45

968578
is: SBO:0000424
value: 0.1
type: LocalParameter

968580
is: SBO:0000194
value: 0.2
type: LocalParameter

http://identifiers.org/biomodels.db/BIOMD0000000044#d7e6d701_8ce4_4a2f_9c52_904a667cb09b
stoichiometry: 1.0
species: metaid_0000010
type: SpeciesReference

968588
is: SBO:0000424
value: 1.0
type: LocalParameter

metaid_0000004
name: minute (default)
type: SBMLUnitsDef

http://identifiers.org/biomodels.db/BIOMD0000000044#facbe4c3_d666_4b18_8b59_aeebeb54f9b7
stoichiometry: 1.0
species: metaid_0000009
type: SpeciesReference

metaid_0000008
initial amount: NaN
is: SBO:0000327
initial concentration: 1000.0
type: Species
boundary condition: false
is: C00076
is: CHEBI:29108
has only substance units: false
constant: false
in compartment: metaid_0000007