metaid_0000062
is version of: IPR003577
constant: false
boundary condition: false
has only substance units: false
initial concentration: 120000.0
initial amount: NaN
in compartment: metaid_0000051
type: Species

metaid_0000089
fast: false
modifier: 915972
reactant: 915948
name: SOS activation by NGF
is version of: GO:0004716
reversible: true
product: 915960
type: Reaction
is version of: http://identifiers.org/ec-code/2.7.1.37
kinetic law: 915984

metaid_0000075
boundary condition: false
has only substance units: false
initial concentration: 120000.0
type: Species
constant: false
in compartment: metaid_0000051
has version: Q63484
has version: P47197
has version: P47196
initial amount: NaN

916924
stoichiometry: 1.0
species: metaid_0000067
type: SpeciesReference

915755
stoichiometry: 1.0
species: metaid_0000055
type: SpeciesReference

BIOMD0000000033
species: metaid_0000071
reaction: metaid_0000100
parameter: metaid_0000007
units def: metaid_0000110
species: metaid_0000075
parameter: metaid_0000031
parameter: metaid_0000019
occurs in: http://identifiers.org/taxonomy/131567
species: metaid_0000083
species: metaid_0000074
species: metaid_0000078
parameter: metaid_0000018
is version of: GO:0048011
species: metaid_0000063
species: metaid_0000054
area units: area
parameter: metaid_0000005
parameter: metaid_0000006
parameter: metaid_0000027
parameter: metaid_0000047
parameter: metaid_0000028
reaction: metaid_0000098
parameter: metaid_0000048
species: metaid_0000062
name: Brown2004_NGF_EGF_signaling
reaction: metaid_0000089
compartment: metaid_0000051
species: metaid_0000066
parameter: metaid_0000012
species: metaid_0000057
parameter: metaid_0000013
reaction: metaid_0000085
parameter: metaid_0000035
reaction: metaid_0000086
parameter: metaid_0000034
reaction: metaid_0000108
reaction: metaid_0000109
reaction: metaid_0000104
is: MODEL6619514794
species: metaid_0000069
parameter: metaid_0000030
reaction: metaid_0000092
reaction: metaid_0000105
reaction: metaid_0000093
parameter: metaid_0000020
is version of: rno04010
curated: true
species: metaid_0000081
species: metaid_0000072
species: metaid_0000076
type: SBMLModel
parameter: metaid_0000016
parameter: metaid_0000017
parameter: metaid_0000039
species: metaid_0000052
is version of: GO:0007173
parameter: metaid_0000003
parameter: metaid_0000004
species: metaid_0000079
reaction: metaid_0000096
reaction: metaid_0000097
species: metaid_0000060
reaction: metaid_0000088
parameter: metaid_0000045
species: metaid_0000064
parameter: metaid_0000046
species: metaid_0000055
parameter: metaid_0000011
reaction: metaid_0000084
species: metaid_0000059
parameter: metaid_0000041
parameter: metaid_0000042
parameter: metaid_0000009
parameter: metaid_0000033
species: metaid_0000067
species: metaid_0000058
reaction: metaid_0000091
parameter: metaid_0000038
is version of: GO:0000165
substance units: metaid_0000110

metaid_0000108
name: BRaf activation by Rap1
reactant: 916862
product: 916874
modifier: 916886
type: Reaction
kinetic law: 916898
reversible: true
is version of: http://identifiers.org/ec-code/2.7.1.37
fast: false
is version of: GO:0000185

916104
stoichiometry: 1.0
species: metaid_0000062
type: SpeciesReference

916188
stoichiometry: 1.0
species: metaid_0000069
type: SpeciesReference

metaid_0000037
constant: true
value: 15.1212
type: Parameter

metaid_0000023
constant: true
value: 2.83243
type: Parameter

916380
stoichiometry: 1.0
species: metaid_0000072
type: SpeciesReference

metaid_0000076
type: Species
constant: false
in compartment: metaid_0000051
boundary condition: false
has version: P47197
has version: P47196
initial concentration: 0.0
initial amount: NaN
has only substance units: false
has version: Q63484

metaid_0000061
has version: Q63531
has version: Q9Z1I2
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: metaid_0000051
type: Species

916536
stoichiometry: 1.0
species: metaid_0000074
type: SpeciesReference

916488
stoichiometry: 1.0
species: metaid_0000061
type: SpeciesReference

metaid_0000109
kinetic law: 916949
modifier: 916937
product: 916924
reactant: 916911
is version of: http://identifiers.org/ec-code/3.1.3.16
fast: false
reversible: true
name: BRaf deactivation by PPase
type: Reaction

metaid_0000110
unit: 915682
name: item (default)
type: SBMLUnitsDef

metaid_0000038
constant: true
value: 119355.0
type: Parameter

metaid_0000020
constant: true
value: 4768350.0
type: Parameter

metaid_0000010
constant: true
value: 2112.66
type: Parameter

metaid_0000024
constant: true
value: 518753.0
type: Parameter

916620
stoichiometry: 1.0
species: metaid_0000075
type: SpeciesReference

metaid_0000060
has version: Q63531
has version: Q9Z1I2
constant: false
boundary condition: false
has only substance units: false
initial concentration: 120000.0
initial amount: NaN
in compartment: metaid_0000051
type: Species

916200
stoichiometry: 1.0
species: metaid_0000070
type: SpeciesReference

metaid_0000077
is version of: Q9QYV3
constant: false
boundary condition: false
has only substance units: false
initial concentration: 120000.0
initial amount: NaN
in compartment: metaid_0000051
type: Species

metaid_0000087
kinetic law: 915888
product: 915876
product: 915864
reactant: 915852
is version of: GO:0051395
fast: false
reversible: false
name: NGF unbinding
type: Reaction

metaid_0000050
constant: true
value: 1.08795E7
type: Parameter

metaid_0000021
constant: true
value: 125.089
type: Parameter

916524
stoichiometry: 1.0
species: metaid_0000073
type: SpeciesReference

metaid_0000035
constant: true
value: 0.0566279
type: Parameter

metaid_0000025
constant: true
value: 9.85367
type: Parameter

915996
stoichiometry: 1.0
species: metaid_0000059
type: SpeciesReference

metaid_0000088
type: Reaction
is version of: GO:0004716
name: SOS activation by EGF
modifier: 915924
kinetic law: 915936
is version of: http://identifiers.org/ec-code/2.7.1.37
reversible: true
fast: false
reactant: 915900
product: 915912

916476
stoichiometry: 1.0
species: metaid_0000060
type: SpeciesReference

915682
exponent: 1.0
scale: 0
multipler: 1.0
kind: ITEM
type: SBMLUnit

metaid_1000110
unit: 915694
name: minute (default)
type: SBMLUnitsDef

915730
stoichiometry: 1.0
species: metaid_0000055
type: SpeciesReference

metaid_0000078
is version of: Q9QYV3
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: metaid_0000051
type: Species

metaid_0000036
constant: true
value: 653951.0
type: Parameter

metaid_0000026
constant: true
value: 1007340.0
type: Parameter

metaid_0000022
constant: true
value: 157948.0
type: Parameter

916874
stoichiometry: 1.0
species: metaid_0000068
type: SpeciesReference

916814
stoichiometry: 1.0
species: metaid_0000080
type: SpeciesReference

metaid_0000079
has version: Q62636
has version: P10113
constant: false
boundary condition: false
has only substance units: false
initial concentration: 120000.0
initial amount: NaN
in compartment: metaid_0000051
type: Species

915960
stoichiometry: 1.0
species: metaid_0000059
type: SpeciesReference

metaid_0000047
constant: true
value: 0.126329
type: Parameter

metaid_0000027
constant: true
value: 8.8912
type: Parameter

915948
stoichiometry: 1.0
species: metaid_0000058
type: SpeciesReference

metaid_0000099
kinetic law: 916464
modifier: 916452
product: 916440
reactant: 916428
is version of: http://identifiers.org/ec-code/3.1.3.16
fast: false
reversible: true
name: Raf1 deactivation by PPase
type: Reaction

metaid_0000104
kinetic law: 916705
modifier: 916693
product: 916681
reactant: 916669
is version of: http://identifiers.org/ec-code/2.7.1.37
fast: false
reversible: true
name: Raf1 deactivation by Akt
type: Reaction

915779
stoichiometry: 1.0
species: metaid_0000054
type: SpeciesReference

metaid_0000009
constant: true
value: 389.428
type: Parameter

916862
stoichiometry: 1.0
species: metaid_0000067
type: SpeciesReference

916572
stoichiometry: 1.0
species: metaid_0000073
type: SpeciesReference

metaid_0000048
constant: true
value: 1061.71
type: Parameter

metaid_0000019
constant: true
value: 185.759
type: Parameter

metaid_0000028
constant: true
value: 3496490.0
type: Parameter

916777
stoichiometry: 1.0
species: metaid_0000080
type: SpeciesReference

metaid_0000105
is version of: GO:0004716
kinetic law: 916753
reversible: true
is version of: http://identifiers.org/ec-code/2.7.1.37
modifier: 916741
reactant: 916717
product: 916729
fast: false
type: Reaction
name: C3G activation

916428
stoichiometry: 1.0
species: metaid_0000066
type: SpeciesReference

916152
stoichiometry: 1.0
species: metaid_0000066
type: SpeciesReference

ORG:
  orgname: Cornell University
n:
  given: Ryan
  family: Gutenkunst

metaid_0000059
is version of: Q9Z1I1
is version of: ENSRNOP00000009359
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: metaid_0000051
type: Species

metaid_0000008
constant: true
value: 6086070.0
type: Parameter

916826
stoichiometry: 1.0
species: metaid_0000079
type: SpeciesReference

metaid_0000049
constant: true
value: 441.287
type: Parameter

915767
stoichiometry: 1.0
species: metaid_0000052
type: SpeciesReference

metaid_0000029
constant: true
value: 0.0213697
type: Parameter

metaid_0000039
constant: true
value: 146.912
type: Parameter

916729
stoichiometry: 1.0
species: metaid_0000078
type: SpeciesReference

metaid_0000106
kinetic law: 916801
modifier: 916789
product: 916777
reactant: 916765
is: GO:0046582
fast: false
reversible: true
name: Rap1 activation
type: Reaction

metaid_0000107
kinetic law: 916850
modifier: 916838
product: 916826
reactant: 916814
fast: false
reversible: true
name: Rap1 deactivation
type: Reaction

916765
stoichiometry: 1.0
species: metaid_0000079
type: SpeciesReference

metaid_0000007
constant: true
value: 694.731
type: Parameter

916092
stoichiometry: 1.0
species: metaid_0000063
type: SpeciesReference

916392
stoichiometry: 1.0
species: metaid_0000071
type: SpeciesReference

915864
stoichiometry: 1.0
species: metaid_0000053
type: SpeciesReference

metaid_0000100
modifier: 916500
product: 916488
reversible: true
is version of: GO:0004707
is version of: http://identifiers.org/ec-code/2.7.1.37
kinetic law: 916512
reactant: 916476
fast: false
type: Reaction
name: P90Rsk activation

metaid_0000006
constant: true
value: 0.00723811
type: Parameter

metaid_0000042
constant: true
value: 10965.6
type: Parameter

metaid_0000016
constant: true
value: 1432410.0
type: Parameter

metaid_0000095
reversible: true
fast: false
name: Mek activation by B-Raf
type: Reaction
is version of: GO:0000186
product: 916248
is version of: GO:0004709
kinetic law: 916272
is version of: http://identifiers.org/ec-code/2.7.1.37
modifier: 916260
reactant: 916236

metaid_0000056
is: P35739
constant: false
boundary condition: false
has only substance units: false
initial concentration: 10000.0
initial amount: NaN
in compartment: metaid_0000051
type: Species

metaid_0000081
is: P47736
constant: true
boundary condition: false
has only substance units: false
initial concentration: 120000.0
initial amount: NaN
in compartment: metaid_0000051
type: Species

916717
stoichiometry: 1.0
species: metaid_0000077
type: SpeciesReference

916681
stoichiometry: 1.0
species: metaid_0000065
type: SpeciesReference

metaid_0000005
constant: true
value: 1.38209E-7
type: Parameter

metaid_0000101
kinetic law: 916560
modifier: 916548
product: 916536
reactant: 916524
is version of: http://identifiers.org/ec-code/2.7.1.37
fast: false
reversible: true
name: PI3K activation by EGFR
type: Reaction

metaid_0000041
constant: true
value: 1.40145
type: Parameter

metaid_0000015
constant: true
value: 1509.36
type: Parameter

916236
stoichiometry: 1.0
species: metaid_0000069
type: SpeciesReference

metaid_0000096
product: 916296
is version of: http://identifiers.org/ec-code/2.7.1.37
reactant: 916284
modifier: 916308
type: Reaction
name: Erk activation
fast: false
is version of: GO:0004708
reversible: true
kinetic law: 916320
is version of: GO:0000187

916911
stoichiometry: 1.0
species: metaid_0000068
type: SpeciesReference

metaid_0000055
has part: P07522
has part: Q9QX70
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: metaid_0000051
type: Species

916044
stoichiometry: 1.0
species: metaid_0000062
type: SpeciesReference

915707
stoichiometry: 1.0
species: metaid_0000052
type: SpeciesReference

metaid_0000082
is: GO:0000159
constant: true
boundary condition: false
has only substance units: false
initial concentration: 120000.0
initial amount: NaN
in compartment: metaid_0000051
type: Species

916669
stoichiometry: 1.0
species: metaid_0000066
type: SpeciesReference

metaid_0000069
is version of: P36506
is version of: Q01986
constant: false
boundary condition: false
has only substance units: false
initial concentration: 600000.0
initial amount: NaN
in compartment: metaid_0000051
type: Species

metaid_0000030
constant: true
value: 763523.0
type: Parameter

metaid_0000102
is version of: GO:0008349
kinetic law: 916608
reversible: true
reactant: 916572
product: 916584
modifier: 916596
type: Reaction
is version of: http://identifiers.org/ec-code/2.7.1.37
fast: false
name: PI3K activation by Ras

metaid_0000004
constant: true
value: 0.0121008
type: Parameter

metaid_0000097
kinetic law: 916368
modifier: 916356
product: 916344
reactant: 916332
is version of: http://identifiers.org/ec-code/3.1.3.16
fast: false
reversible: true
name: Mek deactivation
type: Reaction

915852
stoichiometry: 1.0
species: metaid_0000057
type: SpeciesReference

metaid_0000018
constant: true
value: 62464.6
type: Parameter

metaid_0000040
constant: true
value: 12876.2
type: Parameter

metaid_0000058
is version of: Q9Z1I1
is version of: ENSRNOP00000009359
constant: false
boundary condition: false
has only substance units: false
initial concentration: 120000.0
initial amount: NaN
in compartment: metaid_0000051
type: Species

metaid_0000068
is version of: Q99MC6
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: metaid_0000051
type: Species

metaid_0000003
constant: true
value: 2.18503E-5
type: Parameter

metaid_0000103
kinetic law: 916656
modifier: 916644
product: 916632
reactant: 916620
is version of: GO:0045860
fast: false
reversible: true
name: Akt activation
type: Reaction

916248
stoichiometry: 1.0
species: metaid_0000070
type: SpeciesReference

metaid_0000098
name: Erk deactivation
type: Reaction
modifier: 916404
reactant: 916380
kinetic law: 916416
fast: false
product: 916392
is version of: GO:0000188
reversible: true
is version of: http://identifiers.org/ec-code/3.1.3.16

metaid_0000017
constant: true
value: 0.884096
type: Parameter

915719
stoichiometry: 1.0
species: metaid_0000054
type: SpeciesReference

metaid_0000070
is version of: P36506
is version of: Q01986
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: metaid_0000051
type: Species

915803
stoichiometry: 1.0
species: metaid_0000053
type: SpeciesReference

metaid_0000057
has part: P25427
has part: P35739
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: metaid_0000051
type: Species

metaid_0000080
has version: Q62636
has version: P10113
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: metaid_0000051
type: Species

916140
stoichiometry: 1.0
species: metaid_0000065
type: SpeciesReference

metaid_0000067
is version of: Q99MC6
constant: false
boundary condition: false
has only substance units: false
initial concentration: 120000.0
initial amount: NaN
in compartment: metaid_0000051
type: Species

916056
stoichiometry: 1.0
species: metaid_0000063
type: SpeciesReference

916344
stoichiometry: 1.0
species: metaid_0000069
type: SpeciesReference

915876
stoichiometry: 1.0
species: metaid_0000056
type: SpeciesReference

metaid_0000091
kinetic law: 916080
modifier: 916068
product: 916056
reactant: 916044
is: GO:0046579
fast: false
reversible: true
name: Ras activation
type: Reaction

metaid_0000012
constant: true
value: 896896.0
type: Parameter

metaid_0000046
constant: true
value: 1025460.0
type: Parameter

metaid_0000032
constant: true
value: 184912.0
type: Parameter

915816
stoichiometry: 1.0
species: metaid_0000056
type: SpeciesReference

metaid_0000085
kinetic law: 915791
product: 915779
product: 915767
reactant: 915755
is version of: GO:0007175
fast: false
reversible: false
name: EFG unbinding
type: Reaction

metaid_0000052
is: P07522
constant: false
boundary condition: false
has only substance units: false
initial concentration: 1.0002E7
initial amount: NaN
in compartment: metaid_0000051
type: Species

metaid_0000066
is version of: P11345
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: metaid_0000051
type: Species

metaid_0000071
is version of: P63086
is version of: P21708
constant: false
boundary condition: false
has only substance units: false
initial concentration: 600000.0
initial amount: NaN
in compartment: metaid_0000051
type: Species

916584
stoichiometry: 1.0
species: metaid_0000074
type: SpeciesReference

metaid_0000090
kinetic law: 916032
modifier: 916020
product: 916008
reactant: 915996
is version of: http://identifiers.org/ec-code/2.7.1.37
fast: false
reversible: true
name: SOS deactivation
type: Reaction

metaid_0000092
kinetic law: 916128
modifier: 916116
product: 916104
reactant: 916092
is: GO:0046580
fast: false
reversible: true
name: Ras deactivation
type: Reaction

metaid_0000011
constant: true
value: 1611.97
type: Parameter

916332
stoichiometry: 1.0
species: metaid_0000070
type: SpeciesReference

metaid_0000045
constant: true
value: 2.20995
type: Parameter

metaid_0000031
constant: true
value: 10.6737
type: Parameter

916296
stoichiometry: 1.0
species: metaid_0000072
type: SpeciesReference

metaid_0000086
fast: false
reactant: 915803
name: NGF binding
is version of: GO:0051396
reversible: false
is: GO:0048406
kinetic law: 915840
reactant: 915816
product: 915828
type: Reaction

metaid_0000051
is: GO:0005623
constant: true
size: 1.0
spatial dimensions: 3.0
type: Compartment

915912
stoichiometry: 1.0
species: metaid_0000059
type: SpeciesReference

metaid_0000072
is version of: P63086
is version of: P21708
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: metaid_0000051
type: Species

metaid_0000065
is version of: P11345
constant: false
boundary condition: false
has only substance units: false
initial concentration: 120000.0
initial amount: NaN
in compartment: metaid_0000051
type: Species

metaid_0000014
constant: true
value: 35954.3
type: Parameter

metaid_0000093
is version of: http://identifiers.org/ec-code/2.7.1.37
name: Raf1 activation by Ras
is version of: GO:0008349
modifier: 916164
type: Reaction
reversible: true
is version of: GO:0000185
kinetic law: 916176
product: 916152
reactant: 916140
fast: false

915828
stoichiometry: 1.0
species: metaid_0000057
type: SpeciesReference

metaid_0000034
constant: true
value: 272056.0
type: Parameter

916440
stoichiometry: 1.0
species: metaid_0000065
type: SpeciesReference

metaid_0000044
constant: true
value: 295990.0
type: Parameter

metaid_0000054
is: Q9QX70
constant: false
boundary condition: false
has only substance units: false
initial concentration: 80000.0
initial amount: NaN
in compartment: metaid_0000051
type: Species

metaid_0000083
constant: true
boundary condition: false
has only substance units: false
initial concentration: 120000.0
initial amount: NaN
in compartment: metaid_0000051
type: Species

metaid_0000073
is version of: GO:0005942
has part: IPR015433
constant: false
boundary condition: false
has only substance units: false
initial concentration: 120000.0
initial amount: NaN
in compartment: metaid_0000051
type: Species

916008
stoichiometry: 1.0
species: metaid_0000058
type: SpeciesReference

metaid_0000064
is: P50904
constant: true
boundary condition: false
has only substance units: false
initial concentration: 120000.0
initial amount: NaN
in compartment: metaid_0000051
type: Species

915694
exponent: 1.0
scale: 0
multipler: 60.0
kind: SECOND
type: SBMLUnit

metaid_0000013
constant: true
value: 32.344
type: Parameter

metaid_0000033
constant: true
value: 0.0771067
type: Parameter

metaid_0000094
modifier: 916212
reactant: 916188
is version of: GO:0000186
type: Reaction
name: Mek activation by Raf1
fast: false
reversible: true
is version of: http://identifiers.org/ec-code/2.7.1.37
product: 916200
is version of: GO:0004709
kinetic law: 916224

metaid_0000043
constant: true
value: 27.265
type: Parameter

915900
stoichiometry: 1.0
species: metaid_0000058
type: SpeciesReference

metaid_0000053
is: P25427
constant: false
boundary condition: false
has only substance units: false
initial concentration: 456000.0
initial amount: NaN
in compartment: metaid_0000051
type: Species

metaid_0000084
is: GO:0048408
kinetic law: 915743
type: Reaction
is version of: GO:0045741
reactant: 915707
fast: false
reversible: false
name: EGF binding
product: 915730
reactant: 915719

metaid_0000074
is version of: GO:0005942
has part: IPR015433
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: metaid_0000051
type: Species

916284
stoichiometry: 1.0
species: metaid_0000071
type: SpeciesReference

916632
stoichiometry: 1.0
species: metaid_0000076
type: SpeciesReference

metaid_0000063
is version of: IPR003577
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: metaid_0000051
type: Species

given: Nicolas
family: Le Novère

W3 CDTF: Wed Jul 11 18:30:02 BST 2012

orgname: EMBL-EBI

W3 CDTF: Fri Jun 10 15:09:32 BST 2005