063341
stoichiometry: 1.0
species: metaid_0000008
type: SpeciesReference

metaid_0000043
constant: true
value: 0.47
name: h8
type: Parameter

metaid_0000014
initial amount: NaN
in compartment: metaid_0000004
constant: false
has only substance units: false
type: Species
boundary condition: false
name: MAPK-PY_MKP_Y
initial concentration: 0.0
has part: Q90W58
has part: P26696

metaid_0000024
constant: true
value: 15.0
name: k4
type: Parameter

metaid_0000033
constant: true
value: 0.092
name: h2
type: Parameter

metaid_0000009
is: Q05116
constant: false
boundary condition: false
has only substance units: false
initial concentration: 180.0
initial amount: NaN
in compartment: metaid_0000004
name: MAPKK
type: Species

metaid_0000054
kinetic law: 063605
product: 063593
reactant: 063581
reactant: 063569
is version of: GO:0051019
fast: false
reversible: true
name: binding of MKP on Tyr site of MAPK-PP
type: Reaction

063967
stoichiometry: 1.0
species: metaid_0000008
type: SpeciesReference

064063
stoichiometry: 1.0
species: metaid_0000006
type: SpeciesReference

063847
stoichiometry: 1.0
species: metaid_0000010
type: SpeciesReference

063521
stoichiometry: 1.0
species: metaid_0000012
type: SpeciesReference

metaid_0000044
constant: true
value: 0.14
name: h9
type: Parameter

metaid_0000013
has only substance units: false
initial amount: NaN
constant: false
name: MAPK-PP_MKP_T
type: Species
in compartment: metaid_0000004
boundary condition: false
initial concentration: 0.0
has part: P26696
has part: Q90W58

063473
stoichiometry: 1.0
species: metaid_0000007
type: SpeciesReference

063293
stoichiometry: 1.0
species: metaid_0000009
type: SpeciesReference

metaid_0000034
constant: true
value: 1.0
name: h3
type: Parameter

metaid_0000023
constant: true
value: 1.0
name: k_3
type: Parameter

063786
stoichiometry: 1.0
species: metaid_0001000
type: SpeciesReference

metaid_0001054
kinetic law: 064003
product: 063991
reactant: 063979
reactant: 063967
is version of: GO:0051019
fast: false
reversible: true
name: binding of MKP on Thr site of MAPK-PP
type: Reaction

063653
stoichiometry: 1.0
species: metaid_0000017
type: SpeciesReference

metaid_0000053
product: 063533
is homolog to: REACT 2247
name: tyr phosphorylation of MAPK
kinetic law: 063557
is version of: GO:0018108
is version of: GO:0004708
product: 063545
is version of: GO:0000187
is homolog to: REACT 136
is version of: http://identifiers.org/ec-code/2.7.12.2
reversible: false
reactant: 063521
type: Reaction
fast: false

metaid_0000063
kinetic law: 063955
product: 063943
product: 063931
reactant: 063919
is version of: GO:0043241
fast: false
reversible: true
name: Dissociation MAPK and MKP
type: Reaction

063701
stoichiometry: 1.0
species: metaid_0000007
type: SpeciesReference

063449
stoichiometry: 1.0
species: metaid_0000009
type: SpeciesReference

metaid_0000045
constant: true
value: 0.0018
name: h_9
type: Parameter

063329
stoichiometry: 1.0
species: metaid_0000011
type: SpeciesReference

metaid_0000059
kinetic law: 063907
product: 063895
reactant: 063883
is version of: GO:0006470
is version of: http://identifiers.org/ec-code/3.1.3.16
fast: false
reversible: false
name: dephosphorylation of MAPK-PY
type: Reaction

metaid_0000012
in compartment: metaid_0000004
has only substance units: false
initial amount: NaN
boundary condition: false
constant: false
type: Species
initial concentration: 0.0
has part: Q05116
name: MAPK-PT_MAPKK
has part: P26696

063749
stoichiometry: 1.0
species: metaid_0000018
type: SpeciesReference

metaid_0000031
constant: true
value: 0.045
name: h1
type: Parameter

063353
stoichiometry: 1.0
species: metaid_0000009
type: SpeciesReference

metaid_0000026
constant: true
value: 1.0
name: k_5
type: Parameter

metaid_0001045
constant: true
value: 0.045
name: h10
type: Parameter

063859
stoichiometry: 1.0
species: metaid_0000014
type: SpeciesReference

metaid_0000007
is version of: P26696
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: metaid_0000004
name: MAPK-PT
type: Species

metaid_0000052
type: Reaction
reactant: 063485
kinetic law: 063509
reversible: true
name: binding MAPK-PT and MAPKK
reactant: 063473
is version of: GO:0051019
fast: false
is homolog to: REACT 495
product: 063497
is homolog to: REACT 1780

metaid_0001014
constant: false
has only substance units: false
initial amount: NaN
name: MAPK-PY_MKP_T
initial concentration: 0.0
in compartment: metaid_0000004
has part: P26696
has part: Q90W58
boundary condition: false
type: Species

064051
stoichiometry: 1.0
species: metaid_0001014
type: SpeciesReference

063485
stoichiometry: 1.0
species: metaid_0000009
type: SpeciesReference

metaid_0000046
is homolog to: REACT 495
type: Reaction
product: 063208
is homolog to: REACT 1780
kinetic law: 063220
is version of: GO:0051019
reactant: 063184
name: binding MAPKK on Tyr site of MAPK
reversible: true
reactant: 063196
is version of: GO:0031434
fast: false

metaid_0000011
has part: P26696
initial amount: NaN
in compartment: metaid_0000004
has only substance units: false
has part: Q05116
initial concentration: 0.0
name: MAPK-PY_MAPKK
constant: false
type: Species
boundary condition: false

BIOMD0000000030
is version of: GO:0000165
parameter: metaid_0001047
parameter: metaid_0000020
species: metaid_0000015
species: metaid_0000005
species: metaid_0000007
species: metaid_0000009
parameter: metaid_0001048
parameter: metaid_0000028
parameter: metaid_0000021
curated: true
occurs in: http://identifiers.org/taxonomy/8355
parameter: metaid_0000029
parameter: metaid_0000035
species: metaid_0000016
reaction: metaid_0000050
parameter: metaid_0000030
parameter: metaid_0000036
reaction: metaid_0000056
parameter: metaid_0000038
compartment: metaid_0000004
parameter: metaid_0001045
reaction: metaid_0000063
parameter: metaid_0000026
reaction: metaid_0000051
parameter: metaid_0000031
reaction: metaid_0000053
species: metaid_0000010
parameter: metaid_0000039
reaction: metaid_0001055
parameter: metaid_0000032
reaction: metaid_0000054
species: metaid_0000014
name: Markevich2004_MAPK_AllRandomElementary
parameter: metaid_0000034
reaction: metaid_0000060
species: metaid_0001014
reaction: metaid_0000047
reaction: metaid_0000049
reaction: metaid_0000061
parameter: metaid_0000041
parameter: metaid_0000019
parameter: metaid_0001049
parameter: metaid_0000022
notes: This model originates from BioModels Database: A Database of Annotated Published Models. It is copyright (c) 2005-2009 The BioModels Team. For more information see the terms of use . To cite BioModels Database, please use Le Novère N., Bornstein B., Broicher A., Courtot M., Donizelli M., Dharuri H., Li L., Sauro H., Schilstra M., Shapiro B., Snoep J.L., Hucka M. (2006) BioModels Database: A Free, Centralized Database of Curated, Published, Quantitative Kinetic Models of Biochemical and Cellular Systems Nucleic Acids Res., 34: D689-D691.
length unit: length
type: SBMLModel
reaction: metaid_0001054
reaction: metaid_0000055
parameter: metaid_0000023
parameter: metaid_0000037
species: metaid_0000018
reaction: metaid_0000046
reaction: metaid_0000057
species: metaid_0001001
reaction: metaid_0000058
parameter: metaid_0000043
parameter: metaid_0000045
is described by: http://identifiers.org/pubmed/14744999
species: metaid_0000011
species: metaid_0000013
species: metaid_0001013
units def: metaid_0000003
volume units: metaid_0000323
parameter: metaid_0000033
reaction: metaid_0001056
reaction: metaid_0000059
reaction: metaid_0000048
parameter: metaid_0000027
parameter: metaid_0000040
species: metaid_0000006
species: metaid_0000008
parameter: metaid_0000042
substance units: metaid_0000003
time units: metaid_0000017
area units: area
species: metaid_0000017
species: metaid_0001000
parameter: metaid_0000024
parameter: metaid_0001046

metaid_0000039
constant: true
value: 0.086
name: h6
type: Parameter

metaid_0000032
constant: true
value: 1.0
name: h_1
type: Parameter

063172
exponent: 1.0
scale: -9
multipler: 1.0
kind: MOLE
type: SBMLUnit

063629
stoichiometry: 1.0
species: metaid_0000017
type: SpeciesReference

metaid_0001046
constant: true
value: 1.0
name: h_10
type: Parameter

063389
stoichiometry: 1.0
species: metaid_0000009
type: SpeciesReference

063811
stoichiometry: 1.0
species: metaid_0000010
type: SpeciesReference

metaid_0000025
constant: true
value: 0.02
name: k5
type: Parameter

metaid_0000019
constant: true
value: 0.02
name: k1
type: Parameter

metaid_0000008
is version of: P26696
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: metaid_0000004
name: MAPK-PP
type: Species

063256
stoichiometry: 1.0
species: metaid_0000009
type: SpeciesReference

metaid_0001013
initial concentration: 0.0
type: Species
constant: false
has only substance units: false
initial amount: NaN
in compartment: metaid_0000004
has part: Q90W58
boundary condition: false
name: MAPK-PP_MKP_Y
has part: P26696

metaid_0000051
reversible: false
is homolog to: REACT 136
kinetic law: 063461
is homolog to: REACT 2247
is version of: GO:0004708
fast: false
product: 063437
reactant: 063425
product: 063449
is version of: GO:0018107
type: Reaction
is version of: http://identifiers.org/ec-code/2.7.12.2
name: thr phosphorylation of MAPK

063581
stoichiometry: 1.0
species: metaid_0000010
type: SpeciesReference

metaid_0000050
kinetic law: 063413
type: Reaction
name: binding of MAPKK on Thr site of MAPK
fast: false
reactant: 063377
reactant: 063389
is homolog to: REACT 1780
is version of: GO:0031434
is homolog to: REACT 495
product: 063401
reversible: true
is version of: GO:0051019

metaid_0001047
constant: true
value: 0.092
name: h11
type: Parameter

063991
stoichiometry: 1.0
species: metaid_0001013
type: SpeciesReference

063545
stoichiometry: 1.0
species: metaid_0000009
type: SpeciesReference

metaid_0000038
constant: true
value: 0.5
name: h5
type: Parameter

063232
stoichiometry: 1.0
species: metaid_0000015
type: SpeciesReference

metaid_0000005
is version of: P26696
constant: false
boundary condition: false
has only substance units: false
initial concentration: 800.0
initial amount: NaN
in compartment: metaid_0000004
name: MAPK
type: Species

metaid_0000060
kinetic law: 063823
product: 063811
product: 063798
reactant: 063786
is version of: GO:0043241
fast: false
reversible: true
name: dissociation MAPK and MKP
type: Reaction

metaid_0000018
boundary condition: false
initial concentration: 0.0
has only substance units: false
constant: false
has part: Q90W58
name: MAPK-PT_MKP_T
in compartment: metaid_0000004
type: Species
has part: P26696
initial amount: NaN

063895
stoichiometry: 1.0
species: metaid_0001001
type: SpeciesReference

metaid_0000058
kinetic law: 063737
product: 063725
reactant: 063713
reactant: 063701
is version of: GO:0051019
fast: false
reversible: true
name: binding of MKP on Thr site of MAPK-PT
type: Reaction

metaid_0000048
fast: false
is version of: GO:0031434
reactant: 063281
reactant: 063293
type: Reaction
name: binding of MAPKK on MAPK-PY
product: 063305
kinetic law: 063317
is homolog to: REACT 495
is version of: GO:0051019
is homolog to: REACT 1780
reversible: true

metaid_0000028
constant: true
value: 0.032
name: k7
type: Parameter

063762
stoichiometry: 1.0
species: metaid_0001000
type: SpeciesReference

063208
stoichiometry: 1.0
species: metaid_0000015
type: SpeciesReference

063677
stoichiometry: 1.0
species: metaid_0000010
type: SpeciesReference

metaid_0000040
constant: true
value: 0.0011
name: h_6
type: Parameter

metaid_0001001
has only substance units: false
type: Species
initial concentration: 0.0
name: MAPK_MKP_Y
boundary condition: false
in compartment: metaid_0000004
has part: P26696
constant: false
has part: Q90W58
initial amount: NaN

064027
stoichiometry: 1.0
species: metaid_0001014
type: SpeciesReference

metaid_0001048
constant: true
value: 1.0
name: h12
type: Parameter

metaid_0000030
constant: true
value: 15.0
name: k8
type: Parameter

metaid_0000006
is version of: P26696
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: metaid_0000004
name: MAPK-PY
type: Species

063425
stoichiometry: 1.0
species: metaid_0000016
type: SpeciesReference

063184
stoichiometry: 1.0
species: metaid_0000005
type: SpeciesReference

metaid_0000017
constant: false
boundary condition: false
name: MAPK-PT_MKP_Y
initial concentration: 0.0
has part: P26696
has part: Q90W58
type: Species
in compartment: metaid_0000004
has only substance units: false
initial amount: NaN

063617
stoichiometry: 1.0
species: metaid_0000013
type: SpeciesReference

metaid_0000020
constant: true
value: 1.0
name: k_1
type: Parameter

metaid_0000037
constant: true
value: 1.0
name: h_4
type: Parameter

063725
stoichiometry: 1.0
species: metaid_0000018
type: SpeciesReference

063497
stoichiometry: 1.0
species: metaid_0000012
type: SpeciesReference

metaid_0000057
kinetic law: 063774
product: 063762
reactant: 063749
is version of: GO:0006470
is version of: http://identifiers.org/ec-code/3.1.3.16
fast: false
reversible: false
name: dephosphorylation of MAPK-PT
type: Reaction

metaid_0000047
reversible: false
is homolog to: REACT 136
is version of: GO:0018108
is homolog to: REACT 2247
kinetic law: 063269
product: 063244
product: 063256
name: tyr phosphorylation of MAPK
fast: false
is version of: http://identifiers.org/ec-code/2.7.12.2
type: Reaction
is version of: GO:0004708
reactant: 063232

063943
stoichiometry: 1.0
species: metaid_0000010
type: SpeciesReference

metaid_0000010
is: Q90W58
constant: false
boundary condition: false
has only substance units: false
initial concentration: 100.0
initial amount: NaN
in compartment: metaid_0000004
name: MKP
type: Species

metaid_0000027
constant: true
value: 0.01
name: k6
type: Parameter

metaid_0001049
constant: true
value: 0.01
name: h_12
type: Parameter

metaid_0001000
constant: false
name: MAPK_MKP_T
initial concentration: 0.0
initial amount: NaN
has only substance units: false
type: Species
boundary condition: false
has part: Q90W58
in compartment: metaid_0000004
has part: P26696

063835
stoichiometry: 1.0
species: metaid_0000006
type: SpeciesReference

063533
stoichiometry: 1.0
species: metaid_0000008
type: SpeciesReference

063593
stoichiometry: 1.0
species: metaid_0000013
type: SpeciesReference

063244
stoichiometry: 1.0
species: metaid_0000006
type: SpeciesReference

metaid_0000041
constant: true
value: 0.01
name: h7
type: Parameter

063305
stoichiometry: 1.0
species: metaid_0000011
type: SpeciesReference

063979
stoichiometry: 1.0
species: metaid_0000010
type: SpeciesReference

metaid_0001055
name: dephosphorylation of Thr on MAPKK-PP
reversible: false
kinetic law: 064039
fast: false
product: 064027
reactant: 064015
is version of: GO:0006470
type: Reaction
is version of: http://identifiers.org/ec-code/3.1.3.16
is version of: GO:0000188

063281
stoichiometry: 1.0
species: metaid_0000006
type: SpeciesReference

metaid_0000036
constant: true
value: 0.01
name: h4
type: Parameter

metaid_0000016
initial concentration: 0.0
initial amount: NaN
constant: false
in compartment: metaid_0000004
type: Species
has part: P26696
has part: Q05116
has only substance units: false
name: MAPK_MAPKK_T
boundary condition: false

063377
stoichiometry: 1.0
species: metaid_0000005
type: SpeciesReference

metaid_0000021
constant: true
value: 0.01
name: k2
type: Parameter

metaid_0000003
unit: 063172
name: nanomole (default)
type: SBMLUnitsDef

063401
stoichiometry: 1.0
species: metaid_0000016
type: SpeciesReference

063883
stoichiometry: 1.0
species: metaid_0000014
type: SpeciesReference

metaid_0000056
kinetic law: 063689
product: 063677
product: 063665
reactant: 063653
is version of: GO:0043241
fast: false
reversible: true
name: dissociation MAPK-PT and MKP
type: Reaction

063713
stoichiometry: 1.0
species: metaid_0000010
type: SpeciesReference

063919
stoichiometry: 1.0
species: metaid_0001001
type: SpeciesReference

metaid_0000049
kinetic law: 063365
fast: false
type: Reaction
is version of: http://identifiers.org/ec-code/2.7.12.2
is homolog to: REACT 2247
is homolog to: REACT 136
reactant: 063329
name: thr phosphorylation of MAPK
product: 063353
reversible: false
product: 063341
is version of: GO:0004708
is version of: GO:0000187
is version of: GO:0018107

063437
stoichiometry: 1.0
species: metaid_0000007
type: SpeciesReference

metaid_0000015
name: MAPK_MAPKK_Y
has only substance units: false
in compartment: metaid_0000004
has part: Q05116
boundary condition: false
initial concentration: 0.0
initial amount: NaN
constant: false
has part: P26696
type: Species

metaid_0000061
kinetic law: 063871
product: 063859
reactant: 063847
reactant: 063835
is version of: GO:0051019
fast: false
reversible: true
name: binding of MKP on the Tyr site of MAPK-PY
type: Reaction

064076
stoichiometry: 1.0
species: metaid_0000010
type: SpeciesReference

063665
stoichiometry: 1.0
species: metaid_0000007
type: SpeciesReference

metaid_0000042
constant: true
value: 1.0
name: h_7
type: Parameter

064015
stoichiometry: 1.0
species: metaid_0001013
type: SpeciesReference

metaid_0001056
kinetic law: 064088
product: 064076
product: 064063
reactant: 064051
is version of: GO:0043241
fast: false
reversible: true
name: dissociation MAPK-PY and MKP
type: Reaction

063931
stoichiometry: 1.0
species: metaid_0000005
type: SpeciesReference

metaid_0000035
constant: true
value: 0.01
name: h_3
type: Parameter

063798
stoichiometry: 1.0
species: metaid_0000005
type: SpeciesReference

metaid_0000004
is: GO:0005623
constant: true
size: 1.0
spatial dimensions: 3.0
name: cell
type: Compartment

metaid_0000022
constant: true
value: 0.032
name: k3
type: Parameter

metaid_0000029
constant: true
value: 1.0
name: k_7
type: Parameter

metaid_0000055
product: 063629
is version of: GO:0000188
is version of: http://identifiers.org/ec-code/3.1.3.16
kinetic law: 063641
name: dephosphorylation of Tyr on MAPKK-PP
is version of: GO:0006470
reversible: false
type: Reaction
fast: false
reactant: 063617

063569
stoichiometry: 1.0
species: metaid_0000008
type: SpeciesReference

063196
stoichiometry: 1.0
species: metaid_0000009
type: SpeciesReference

ORG:
  orgname: EMBL-EBI
n:
  given: Nicolas
  family: Le Novère

W3 CDTF: Thu May 26 09:51:45 BST 2005

W3 CDTF: Tue May 15 22:43:15 BST 2012