metaid_0000007
is version of: P26696
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: metaid_0000004
name: ERK-PT
type: Species

metaid_0000017
constant: true
value: 300.0
name: Km4
type: Parameter

metaid_0000003
unit: 051390
name: nanomole (default)
type: SBMLUnitsDef

051414
stoichiometry: 1.0
species: metaid_0000006
type: SpeciesReference

metaid_0000023
constant: true
value: 34.0
name: Km7
type: Parameter

metaid_0000013
constant: true
value: 40.0
name: Km2
type: Parameter

metaid_0000026
is homolog to: REACT 136
name: phosphorylation of ERK on Tyr
is version of: GO:0018108
modifier: 051438
reversible: false
is version of: http://identifiers.org/ec-code/2.7.12.2
product: 051414
kinetic law: 051450
type: Reaction
is homolog to: REACT 2247
is version of: GO:0004708
fast: false
modifier: 051426
reactant: 051402

051813
stoichiometry: 1.0
species: metaid_0000006
type: SpeciesReference

metaid_0000032
reactant: 051813
product: 051825
type: Reaction
reversible: false
name: dephosphorylation of ERK-PY
kinetic law: 051873
is version of: http://identifiers.org/ec-code/3.1.3.16
modifier: 051837
fast: false
modifier: 051861
is version of: GO:0006470
modifier: 051849

metaid_0000016
constant: true
value: 0.008
name: kcat3
type: Parameter

BIOMD0000000029
species: metaid_0000005
compartment: metaid_0000004
units def: metaid_0000003
modified:
  W3 CDTF: Tue May 15 22:42:56 BST 2012
reaction: metaid_0000029
parameter: metaid_0000022
parameter: metaid_0000014
reaction: metaid_0000032
volume units: metaid_0000323
notes: The model corresponds to the schema 3 of Markevich et al 2004, as described in the figure 2 and the supplementary table S3, and modelled using Michaelis-Menten like kinetics. Phosphorylations follow distributive random kinetics, while dephosphorylations follow an ordered mechanism. This model originates from BioModels Database: A Database of Annotated Published Models. It is copyright (c) 2005-2007 The BioModels Team. For more information see theterms of use .
type: SBMLModel
species: metaid_0000006
time units: metaid_0000017
parameter: metaid_0000017
reaction: metaid_0000028
area units: area
parameter: metaid_0000021
reaction: metaid_0000031
parameter: metaid_0000025
name: Markevich2004_MAPK_phosphoRandomMM
creator:
  ORG:
    orgname: EMBL-EBI
  n:
    given: Nicolas
    family: Le Novère
is: MODEL6618620128
parameter: metaid_0000013
species: metaid_0000007
reaction: metaid_0000027
curated: true
parameter: metaid_0000019
parameter: metaid_0000016
is version of: GO:0000165
reaction: metaid_0000030
length unit: length
occurs in: http://identifiers.org/taxonomy/8355
parameter: metaid_0000023
parameter: metaid_0000024
species: metaid_0000008
species: metaid_0000010
substance units: metaid_0000003
parameter: metaid_0000011
parameter: metaid_0000020
parameter: metaid_0000015
species: metaid_0000009
parameter: metaid_0000012
is described by: http://identifiers.org/pubmed/14744999
reaction: metaid_0000026
parameter: metaid_0000018
created:
  W3 CDTF: Tue May 24 11:57:06 BST 2005

051474
stoichiometry: 1.0
species: metaid_0000008
type: SpeciesReference

metaid_0000012
constant: true
value: 1.08
name: kcat1
type: Parameter

metaid_0000006
is version of: P26696
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: metaid_0000004
name: ERK-PY
type: Species

051752
stoichiometry: 1.0
species: metaid_0000005
type: SpeciesReference

metaid_0000022
constant: true
value: 0.06
name: kcat6
type: Parameter

051680
stoichiometry: 1.0
species: metaid_0000007
type: SpeciesReference

051536
stoichiometry: 1.0
species: metaid_0000005
type: SpeciesReference

051596
stoichiometry: 1.0
species: metaid_0000007
type: SpeciesReference

metaid_0000027
is version of: GO:0004708
reversible: false
is version of: GO:0000187
is homolog to: REACT 2247
modifier: 051498
modifier: 051486
fast: false
is version of: GO:0018107
product: 051474
modifier: 051510
kinetic law: 051523
is version of: http://identifiers.org/ec-code/2.7.12.2
type: Reaction
is homolog to: REACT 136
reactant: 051462
name: phosphorylation of ERK-PY on Thr

metaid_0000031
fast: false
reversible: false
product: 051752
is version of: http://identifiers.org/ec-code/3.1.3.16
modifier: 051764
modifier: 051776
is version of: GO:0006470
kinetic law: 051800
name: dephosphorylation of ERK-PT
reactant: 051740
type: Reaction
modifier: 051788

051402
stoichiometry: 1.0
species: metaid_0000005
type: SpeciesReference

metaid_0000019
constant: true
value: 22.0
name: Km5
type: Parameter

metaid_0000021
constant: true
value: 18.0
name: Km6
type: Parameter

metaid_0000005
is version of: P26696
constant: false
boundary condition: false
has only substance units: false
initial concentration: 800.0
initial amount: NaN
in compartment: metaid_0000004
name: ERK
type: Species

metaid_0000015
constant: true
value: 20.0
name: Km3
type: Parameter

metaid_0000030
modifier: 051692
reversible: false
product: 051680
is version of: GO:0006470
is version of: GO:0000188
reactant: 051668
is version of: http://identifiers.org/ec-code/3.1.3.16
kinetic law: 051728
fast: false
modifier: 051716
name: dephosphorylation of ERK-PP on Tyr
type: Reaction
modifier: 051704

metaid_0000024
constant: true
value: 0.108
name: kcat7
type: Parameter

metaid_0000020
constant: true
value: 0.084
name: kcat5
type: Parameter

051608
stoichiometry: 1.0
species: metaid_0000008
type: SpeciesReference

metaid_0000010
is: Q90W58
constant: true
boundary condition: false
has only substance units: false
initial concentration: 100.0
initial amount: NaN
in compartment: metaid_0000004
name: MKP3
type: Species

metaid_0000028
reactant: 051536
modifier: 051572
reversible: false
is version of: http://identifiers.org/ec-code/2.7.12.2
is homolog to: REACT 2247
is version of: GO:0018107
kinetic law: 051584
type: Reaction
modifier: 051560
name: phosphorylation of ERK on Thr
fast: false
product: 051548
is version of: GO:0004708
is homolog to: REACT 136

metaid_0000009
is: Q05116
constant: true
boundary condition: false
has only substance units: false
initial concentration: 180.0
initial amount: NaN
in compartment: metaid_0000004
name: MEK
type: Species

051668
stoichiometry: 1.0
species: metaid_0000008
type: SpeciesReference

051462
stoichiometry: 1.0
species: metaid_0000006
type: SpeciesReference

051825
stoichiometry: 1.0
species: metaid_0000005
type: SpeciesReference

metaid_0000004
is: GO:0005623
constant: true
size: 1.0
spatial dimensions: 3.0
name: cell
type: Compartment

metaid_0000018
constant: true
value: 0.45
name: kcat4
type: Parameter

metaid_0000014
constant: true
value: 0.007
name: kcat2
type: Parameter

metaid_0000025
constant: true
value: 40.0
name: Km8
type: Parameter

051390
exponent: 1.0
scale: -9
multipler: 1.0
kind: MOLE
type: SBMLUnit

metaid_0000029
is version of: http://identifiers.org/ec-code/2.7.12.2
is homolog to: REACT 2247
reactant: 051596
kinetic law: 051656
is homolog to: REACT 136
modifier: 051644
reversible: false
is version of: GO:0004708
is version of: GO:0000187
type: Reaction
is version of: GO:0018108
name: phosphorylation of ERK-PT on Tyr
product: 051608
modifier: 051632
fast: false
modifier: 051620

051740
stoichiometry: 1.0
species: metaid_0000007
type: SpeciesReference

metaid_0000011
constant: true
value: 410.0
name: Km1
type: Parameter

051548
stoichiometry: 1.0
species: metaid_0000007
type: SpeciesReference

metaid_0000008
is version of: P26696
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: metaid_0000004
name: ERK-PP
type: Species