012269
stoichiometry: 1.0
species: metaid_0000024
type: SpeciesReference

011980
stoichiometry: 1.0
species: metaid_0000026
type: SpeciesReference

metaid_0000034
product: 012004
reactant: 011980
fast: false
is version of: GO:0006468
is homolog to: REACT 136
type: Reaction
kinetic law: 012016
is version of: GO:0004708
is homolog to: REACT 2247
is version of: http://identifiers.org/ec-code/2.7.12.2
product: 011992
reversible: false
is version of: GO:0000187
name: phosphorylation of P-MAPK

metaid_0000013
constant: true
value: 0.01
type: Parameter

012185
stoichiometry: 1.0
species: metaid_0000029
type: SpeciesReference

metaid_0000003
constant: true
value: 0.02
type: Parameter

011895
stoichiometry: 1.0
species: metaid_0000021
type: SpeciesReference

011943
stoichiometry: 1.0
species: metaid_0000023
type: SpeciesReference

metaid_0000035
reactant: 012041
reversible: true
type: Reaction
name: binding MKP and PP-MAPK
kinetic law: 012065
product: 012053
fast: false
is version of: GO:0031434
reactant: 012029
is version of: GO:0051019

metaid_0000012
constant: true
value: 1.0
type: Parameter

012125
stoichiometry: 1.0
species: metaid_0000021
type: SpeciesReference

011823
exponent: 1.0
scale: -9
multipler: 1.0
kind: MOLE
type: SBMLUnit

metaid_0000009
constant: true
value: 0.045
type: Parameter

012077
stoichiometry: 1.0
species: metaid_0000027
type: SpeciesReference

metaid_0000029
has only substance units: false
in compartment: metaid_0000019
initial concentration: NaN
name: Mp_MKP*
initial amount: 0.0
boundary condition: false
has part: P26696
constant: false
has part: Q90W58
type: Species

012173
stoichiometry: 1.0
species: metaid_0000024
type: SpeciesReference

metaid_0000032
is homolog to: REACT 136
reactant: 011883
kinetic law: 011919
is version of: GO:0004708
is version of: GO:0006468
name: phosphorylation of MAPK
is homolog to: REACT 2247
type: Reaction
product: 011907
fast: false
is version of: http://identifiers.org/ec-code/2.7.12.2
product: 011895
reversible: false

BIOMD0000000026
species: metaid_0000029
type: SBMLModel
species: metaid_0000025
reaction: metaid_0000039
reaction: metaid_0000031
parameter: metaid_0000009
reaction: metaid_0000036
area units: area
reaction: metaid_0000034
parameter: metaid_0000014
units def: metaid_0000041
compartment: metaid_0000019
parameter: metaid_0000007
parameter: metaid_0000017
parameter: metaid_0000011
species: metaid_0000023
species: metaid_0000028
parameter: metaid_0000004
species: metaid_0000024
created:
  W3 CDTF: Mon May 23 13:47:22 BST 2005
modified:
  W3 CDTF: Tue May 15 22:41:59 BST 2012
species: metaid_0000027
substance units: metaid_0000041
reaction: metaid_0000037
reaction: metaid_0000035
parameter: metaid_0000015
volume units: metaid_0000323
reaction: metaid_0000032
parameter: metaid_0000012
is version of: GO:0000165
parameter: metaid_0000018
time units: metaid_0000017
species: metaid_0000022
is: MODEL6618379269
occurs in: http://identifiers.org/taxonomy/8355
creator:
  ORG:
    orgname: EMBL-EBI
  n:
    given: Nicolas
    family: Le Novère
curated: true
parameter: metaid_0000005
species: metaid_0000021
reaction: metaid_0000038
species: metaid_0000026
reaction: metaid_0000040
parameter: metaid_0000008
name: Markevich2004_MAPK_orderedElementary
is described by: http://identifiers.org/pubmed/14744999
reaction: metaid_0000033
parameter: metaid_0000003
parameter: metaid_0000013
creator:
  ORG:
    orgname: University of Vienna
  n:
    given: Rainer
    family: Machne
species: metaid_0000030
parameter: metaid_0000006
parameter: metaid_0000016
parameter: metaid_0000010
notes: The model corresponds to the schemas 1 and 2 of Markevich et al 2004, as described in the figure 1 and the supplementary table S1. Phosphorylations and dephosphorylations follow distributive ordered kinetics. The phosphorylations are modeled with three elementary reactions: E+S<=>ES->E+P The dephosphorylations are modeled with five elementary reactions: E+S<=>ES->EP<=>E+P
length unit: length
species: metaid_0000020

metaid_0000015
constant: true
value: 1.0
type: Parameter

metaid_0000008
constant: true
value: 15.0
type: Parameter

011859
stoichiometry: 1.0
species: metaid_0000025
type: SpeciesReference

metaid_0000028
boundary condition: false
type: Species
has only substance units: false
has part: Q90W58
initial amount: 0.0
in compartment: metaid_0000019
constant: false
name: Mp_MKP
has part: P26696
initial concentration: NaN

011955
stoichiometry: 1.0
species: metaid_0000026
type: SpeciesReference

011883
stoichiometry: 1.0
species: metaid_0000025
type: SpeciesReference

012004
stoichiometry: 1.0
species: metaid_0000023
type: SpeciesReference

012113
stoichiometry: 1.0
species: metaid_0000028
type: SpeciesReference

metaid_0000014
constant: true
value: 0.01
type: Parameter

metaid_0000033
is homolog to: REACT 1780
reversible: true
is homolog to: REACT 495
reactant: 011943
product: 011955
type: Reaction
kinetic law: 011967
is version of: GO:0031434
name: binding PP-MAPKK and P-MAPK
reactant: 011931
is version of: GO:0051019
fast: false

metaid_0000010
constant: true
value: 1.0
type: Parameter

metaid_0000027
boundary condition: false
type: Species
in compartment: metaid_0000019
name: Mpp_MKP
has part: P26696
initial amount: 0.0
has part: Q90W58
constant: false
has only substance units: false
initial concentration: NaN

metaid_0000037
kinetic law: 012149
product: 012137
product: 012125
reactant: 012113
is version of: GO:0043241
fast: false
reversible: true
name: dissociation of MKP from P-MAPK
type: Reaction

012161
stoichiometry: 1.0
species: metaid_0000021
type: SpeciesReference

metaid_0000020
is version of: P26696
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 500.0
in compartment: metaid_0000019
type: Species

012089
stoichiometry: 1.0
species: metaid_0000028
type: SpeciesReference

metaid_0000017
constant: true
value: 0.086
type: Parameter

metaid_0000040
kinetic law: 012281
product: 012269
product: 012257
reactant: 012245
is version of: GO:0043241
fast: false
reversible: true
name: dissociation of MKP from MAPK
type: Reaction

011907
stoichiometry: 1.0
species: metaid_0000023
type: SpeciesReference

012245
stoichiometry: 1.0
species: metaid_0000030
type: SpeciesReference

metaid_0000030
initial amount: 0.0
in compartment: metaid_0000019
constant: false
has part: Q90W58
boundary condition: false
has only substance units: false
type: Species
name: M_MKP
has part: P26696
initial concentration: NaN

metaid_0000007
constant: true
value: 1.0
type: Parameter

metaid_0000036
fast: false
is version of: http://identifiers.org/ec-code/3.1.3.16
reversible: false
kinetic law: 012101
name: dephosphorylation of PP-MAPK
is version of: GO:0006470
product: 012089
type: Reaction
reactant: 012077
is version of: GO:0000188

metaid_0000026
has part: P26696
has part: Q05116
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: metaid_0000019
type: Species

metaid_0000011
constant: true
value: 0.092
type: Parameter

metaid_0000021
is version of: P26696
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: metaid_0000019
type: Species

metaid_0000016
constant: true
value: 0.5
type: Parameter

011847
stoichiometry: 1.0
species: metaid_0000023
type: SpeciesReference

012053
stoichiometry: 1.0
species: metaid_0000027
type: SpeciesReference

metaid_0000041
unit: 011823
name: nanomole (default)
type: SBMLUnitsDef

metaid_0000031
kinetic law: 011871
is homolog to: REACT 495
is version of: GO:0051019
product: 011859
name: binding MAPK and PP-MAPKK
fast: false
is version of: GO:0031434
type: Reaction
reactant: 011847
reversible: true
is homolog to: REACT 1780
reactant: 011835

metaid_0000006
constant: true
value: 0.032
type: Parameter

metaid_0000022
is version of: P26696
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: metaid_0000019
type: Species

metaid_0000039
kinetic law: 012233
product: 012221
reactant: 012209
is version of: http://identifiers.org/ec-code/3.1.3.16
fast: false
reversible: false
name: dephosphorylation of P-MAPK
type: Reaction

metaid_0000025
has part: Q05116
has part: P26696
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: metaid_0000019
type: Species

metaid_0000019
constant: true
size: 1.0
spatial dimensions: 3.0
type: Compartment

011992
stoichiometry: 1.0
species: metaid_0000022
type: SpeciesReference

metaid_0000005
constant: true
value: 0.01
type: Parameter

012209
stoichiometry: 1.0
species: metaid_0000029
type: SpeciesReference

012257
stoichiometry: 1.0
species: metaid_0000020
type: SpeciesReference

012029
stoichiometry: 1.0
species: metaid_0000022
type: SpeciesReference

012137
stoichiometry: 1.0
species: metaid_0000024
type: SpeciesReference

metaid_0000024
is: Q90W58
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 100.0
in compartment: metaid_0000019
name: MKP
type: Species

012221
stoichiometry: 1.0
species: metaid_0000030
type: SpeciesReference

metaid_0000023
is: Q05116
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 50.0
in compartment: metaid_0000019
type: Species

metaid_0000038
kinetic law: 012197
product: 012185
reactant: 012173
reactant: 012161
is version of: GO:0051019
fast: false
reversible: true
name: binding MKP and P-MAPK
type: Reaction

metaid_0000018
constant: true
value: 0.0011
type: Parameter

011835
stoichiometry: 1.0
species: metaid_0000020
type: SpeciesReference

metaid_0000004
constant: true
value: 1.0
type: Parameter

012041
stoichiometry: 1.0
species: metaid_0000024
type: SpeciesReference

011931
stoichiometry: 1.0
species: metaid_0000021
type: SpeciesReference