metaid_0000029
notes: auxiliary beta_h
constant: false
value: NaN
name: beta_h
type: Parameter

metaid_0000022
notes: maximum leakage conductance
is: SBO:0000257
constant: true
value: 0.3
name: g_L
type: Parameter

metaid_0000032
constant: true
size: 1.0
spatial dimensions: 3.0
name: unit_compartment
type: Compartment

metaid_0000019
notes: membrane capacitance
is: SBO:0000258
constant: true
value: 1.0
name: Cm
type: Parameter

metaid_0000039
notes: beta_h = 1.0 /(exp[0.1 * (V + 30.0)] + 1.0)

metaid_0000046
notes: dh/dt = alpha_h * (1.0 - h) - beta_h * h
is part of: GO:0005248

metaid_0000025
notes: leakage equilibrium potential
is: SBO:0000259
constant: true
units: metaid_0000050
value: -85.613
name: E_L
type: Parameter

BIOMD0000000020
rule: metaid_0000047
units def: metaid_0000050
compartment: metaid_0000032
modified:
  W3 CDTF: Wed Feb 02 23:00:36 GMT 2011
created:
  W3 CDTF: Thu Mar 31 14:09:21 BST 2005
is version of: GO:0019227
parameter: metaid_0000010
parameter: metaid_0000011
rule: metaid_0000036
rule: metaid_0000044
is version of: GO:0005249
parameter: metaid_0001023
parameter: metaid_0000023
rule: metaid_0000039
rule: metaid_0000034
rule: metaid_0000041
parameter: metaid_0000024
substance units: metaid_0000321
type: SBMLModel
parameter: metaid_0000014
parameter: metaid_0000015
creator:
  ORG:
    orgname: SBML Team - Science and Technology Research Institute - University of Hertfordshire
  n:
    given: Maria
    family: Schilstra
occurs in: GO:0042757
parameter: metaid_0000017
rule: metaid_0000042
is described by: http://identifiers.org/pubmed/12991237
creator:
  ORG:
    orgname: University of Auckland
  n:
    given: Catherine
    family: Lloyd
is version of: GO:0005248
rule: metaid_0000037
rule: metaid_0000045
parameter: metaid_0001011
parameter: metaid_0000021
parameter: metaid_0000022
rule: metaid_0000035
parameter: metaid_0000012
parameter: metaid_0000013
area units: area
rule: metaid_0000043
rule: metaid_0000135
rule: metaid_0001135
parameter: metaid_0000027
parameter: metaid_0001024
parameter: metaid_0001025
creator:
  ORG:
    orgname: EMBL-EBI
  n:
    given: Lukas
    family: Endler
parameter: metaid_0000029
length unit: length
rule: metaid_0000038
rule: metaid_0000048
parameter: metaid_0000030
is: MODEL6617668482
parameter: metaid_0000031
rule: metaid_0000046
curated: true
time units: metaid_0000003
parameter: metaid_0000016
parameter: metaid_0001010
notes: This is an implementation of the Hodgkin-Huxley model of the electrical behavior of the squid axon membrane from: A quantitative description of membrane current and its application to conduction and excitation in nerve. A. L. Hodgkin and A. F. Huxley. (1952 ) Journal of Physiology 119(4): pp 500-544; pmID: 12991237 . Abstract: This article concludes a series of papers concerned with the flow of electric current through the surface membrane of a giant nerve fibre (Hodgkin,Huxley & Katz, 1952; Hodgkin & Huxley, 1952 a-c). Its general object is to discuss the results of the preceding papers (Part I), to put them into mathematical form (Part II) and to show that they will account for conduction and excitation in quantitative terms (Part III). This SBML model uses the same formalism as the one described in the paper, contrary to modern versions: * V describes the the membrane depolarisation relative to the resting potential of the membrane * opposing to modern practice, depolarization is negative , not positive , so the sign of V is different * inward transmembrane currents are considered positive (inward current positive), contrary to modern use The changeable parameters are the equilibrium potentials( E_R, E_K, E_L, E_Na ), the membrane depolarization ( V ) and the initial sodium and potassium channel activation and inactivation coefficients ( m,h,n ). The initial values of m,h,n for the model were calculated for V = 0 using the equations from the article: n t=0 = α_n V=0 /(α_n V=0 + β_n V=0 ) and equivalent expressions for h and m . For single excitations apply a negative membrane depolarization (V < 0). To achieve oscillatory behavior either change the resting potential to a more positive value or apply a constant negative ionic current (I < 0). Two assignments for parameters in the model, alpha_n and alpha_m, are not defined at V=-10 resp. -25 mV. We did not change this to keep the formulas similar to the original publication and as most integrators seem not to have…
units def: metaid_0000003
parameter: metaid_0000020
volume units: metaid_0000323
name: hodgkin-huxley squid-axon 1952
rule: metaid_0000033
rule: metaid_0000040
parameter: metaid_0000025
occurs in: http://identifiers.org/taxonomy/6618
parameter: metaid_0000026
parameter: metaid_0000028
parameter: metaid_0000018
parameter: metaid_0000019

metaid_0000042
notes: i_Na = g_Na * m^3.0 * h * (V - V_Na)
is version of: GO:0006814

metaid_0000011
notes: applied current
constant: true
value: 0.0
name: I
type: Parameter

metaid_0000015
notes: sodium channel activation coefficient m t=0 = α_m V=0 /(α_m V=0 + β_m V=0 )
constant: false
value: 0.052932
name: m
type: Parameter

metaid_0000023
notes: sodium equilibrium potential
is: SBO:0000259
constant: true
units: metaid_0000050
value: -190.0
name: E_Na
type: Parameter

metaid_0000003
unit: 922669
name: millisecond
type: SBMLUnitsDef

metaid_0000028
notes: membrane depolarisation
constant: false
value: NaN
name: auxiliary alpha_h
type: Parameter

metaid_0000048
notes: dV/dt = (I - (i_Na + i_K + i_L))/Cm

metaid_0000038
notes: alpha_h = 0.07 * exp[V / 20.0]

metaid_0001023
notes: sodium potential displacement
is: SBO:0000259
constant: false
units: metaid_0000050
value: -115.0
name: V_Na
type: Parameter

metaid_0000033
notes: V_Na = E_Na - E_R

metaid_0000018
notes: resting membrane potential
is: SBO:0000259
constant: true
units: metaid_0000050
value: -75.0
name: E_R
type: Parameter

metaid_0001135
notes: V_neg = -V

metaid_0000024
notes: potassium equilibrium potential
is: SBO:0000259
constant: true
units: metaid_0000050
value: -63.0
name: E_K
type: Parameter

metaid_0000047
notes: dn/dt = alpha_n * (1.0 - n) - beta_n * n
is part of: GO:0005249

metaid_0000014
notes: leakage current
is version of: GO:0022840
constant: false
value: NaN
name: i_L
type: Parameter

metaid_0000010
notes: membrane depolarisation
is: SBO:0000259
constant: false
units: metaid_0000050
value: 0.0
name: V
type: Parameter

metaid_0000043
notes: i_K = g_K * n^4.0 * (V - V_K)
is version of: GO:0006813

922669
exponent: 1.0
scale: -3
multipler: 1.0
kind: SECOND
type: SBMLUnit

922681
exponent: 1.0
scale: -3
multipler: 1.0
kind: VOLT
type: SBMLUnit

metaid_0000020
notes: maximum sodium channel conductance
is: SBO:0000257
constant: true
value: 120.0
name: g_Na
type: Parameter

metaid_0001024
notes: potassium potential displacement
is: SBO:0000259
constant: false
units: metaid_0000050
value: 12.0
name: V_K
type: Parameter

metaid_0000050
unit: 922681
name: mV
type: SBMLUnitsDef

metaid_0000017
notes: potassium channel activation coefficient n t=0 = α_n V=0 /(α_n V=0 + β_n V=0 )
constant: false
value: 0.31768
name: n
type: Parameter

metaid_0000034
notes: V_K = E_K - E_R

metaid_0000030
notes: auxiliary alpha_n
constant: false
value: NaN
name: alpha_n
type: Parameter

metaid_0000037
notes: beta_m = 4.0 * exp[V / 18.0]

metaid_0001010
notes: transmembrane potential
is: SBO:0000259
constant: false
units: metaid_0000050
value: NaN
name: E
type: Parameter

metaid_0000027
notes: auxiliary beta_m
constant: false
value: NaN
name: beta_m
type: Parameter

metaid_0000040
notes: alpha_n = 0.01 * (V + 10.0)/(exp[0.1 * (V + 10.0)] - 1.0)

metaid_0000044
notes: i_L = g_L * (V - V_L)
is version of: GO:0006811

metaid_0000013
notes: potassium current
is version of: GO:0008076
constant: false
value: NaN
name: i_K
type: Parameter

metaid_0001025
notes: leakage potential displacement
is: SBO:0000259
constant: false
units: metaid_0000050
value: -10.613
name: V_L
type: Parameter

metaid_0000031
notes: auxiliary beta_n
constant: false
value: NaN
name: beta_n
type: Parameter

metaid_0000021
notes: maximum potassium channel conductance
is: SBO:0000257
constant: true
value: 36.0
name: g_K
type: Parameter

metaid_0000035
notes: V_L = E_L - E_R

metaid_0000036
notes: alpha_m = 0.1 * (V + 25.0)/(exp[0.1 * (V + 25.0)] - 1.0)

metaid_0000041
notes: beta_n = 0.125 * exp[V / 80.0]

metaid_0000026
notes: auxiliary alpha_m
constant: false
value: NaN
name: alpha_m
type: Parameter

metaid_0001011
notes: negative membrane depolarisation
is: SBO:0000259
constant: false
units: metaid_0000050
value: NaN
name: V_neg
type: Parameter

metaid_0000016
notes: sodium channel inactivation coefficient h t=0 = α_h V=0 /(α_h V=0 + β_h V=0 )
constant: false
value: 0.59612
name: h
type: Parameter

metaid_0000045
notes: dm/dt = alpha_m * (1.0 - m) - beta_m * m
is part of: GO:0005248

metaid_0000012
notes: sodium current
is version of: GO:0005248
constant: false
value: NaN
name: i_Na
type: Parameter

metaid_0000135
notes: E = V + E_R