865146
stoichiometry: 1.0
species: metaid_0000030
type: SpeciesReference

865339
stoichiometry: 1.0
species: metaid_0000014
type: SpeciesReference

861184
stoichiometry: 1.0
species: metaid_0000031
type: SpeciesReference

metaid_0000026
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: metaid_0000005
name: EGF-EGFRi*^2-GAP-Grb2-Sos-Ras-GTP
type: Species

861123
stoichiometry: 1.0
species: metaid_0000048
type: SpeciesReference

861789
stoichiometry: 1.0
species: metaid_0000020
type: SpeciesReference

864978
stoichiometry: 1.0
species: metaid_0000065
type: SpeciesReference

metaid_0000232
kinetic law: 861148
product: 861135
reactant: 861123
reactant: 861111
fast: false
reversible: true
name: v20
type: Reaction

860696
stoichiometry: 1.0
species: metaid_0000021
type: SpeciesReference

metaid_0000161
constant: true
units: metaid_0000324
value: 360.0
type: Parameter

metaid_0000212
constant: true
units: metaid_0000324
value: 0.01002
type: Parameter

861837
stoichiometry: 1.0
species: metaid_0000029
type: SpeciesReference

862732
stoichiometry: 1.0
species: metaid_0000056
type: SpeciesReference

metaid_0000276
kinetic law: 863216
product: 863204
reactant: 863192
reactant: 863180
fast: false
reversible: true
name: v64
type: Reaction

metaid_0000025
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: metaid_0000005
name: EGF-EGFRi*^2-GAP-Grb2-Sos-Ras-GDP
type: Species

860358
stoichiometry: 2.0
species: metaid_0000008
type: SpeciesReference

861874
stoichiometry: 1.0
species: metaid_0000045
type: SpeciesReference

861437
stoichiometry: 1.0
species: metaid_0000041
type: SpeciesReference

metaid_0000274
kinetic law: 863119
product: 863107
reactant: 863095
fast: false
reversible: false
name: v62
type: Reaction

860177
exponent: 1.0
scale: 0
multipler: 1.0
kind: ITEM
type: SBMLUnit

metaid_0000231
kinetic law: 861099
product: 861087
product: 861074
reactant: 861061
fast: false
reversible: true
name: v19
type: Reaction

metaid_0000079
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: metaid_0000005
name: MEKi-Rafi*
type: Species

metaid_0000230
kinetic law: 861049
product: 861037
reactant: 861025
reactant: 861012
fast: false
reversible: true
name: v18
type: Reaction

metaid_0000162
constant: true
units: metaid_0000324
value: 36.0
type: Parameter

862455
stoichiometry: 1.0
species: metaid_0000058
type: SpeciesReference

metaid_0000211
constant: true
units: metaid_0000324
value: 0.04002
type: Parameter

861400
stoichiometry: 1.0
species: metaid_0000040
type: SpeciesReference

metaid_0000275
kinetic law: 863167
product: 863155
reactant: 863143
reactant: 863131
fast: false
reversible: true
name: v63
type: Reaction

metaid_0000028
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: metaid_0000005
name: EGF-EGFR*^2-GAP-Grb2
type: Species

metaid_0000234
kinetic law: 861244
product: 861232
reactant: 861220
reactant: 861208
fast: false
reversible: true
name: v22
type: Reaction

864132
stoichiometry: 1.0
species: metaid_0000049
type: SpeciesReference

metaid_0000078
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: metaid_0000005
name: Rafi*-P'ase
type: Species

metaid_0000214
fast: false
reversible: true
kinetic law: 860382
reactant: 860358
is version of: REACT 9397
is version of: GO:0046983
type: Reaction
is version of: GO:0007171
product: 860370
name: v2

metaid_0000163
constant: true
units: metaid_0000326
value: 0.001
type: Parameter

metaid_0000278
kinetic law: 863313
product: 863301
product: 863289
reactant: 863277
fast: false
reversible: true
name: v66
type: Reaction

862843
stoichiometry: 1.0
species: metaid_0000065
type: SpeciesReference

861220
stoichiometry: 1.0
species: metaid_0000020
type: SpeciesReference

860503
stoichiometry: 1.0
species: metaid_0000014
type: SpeciesReference

864047
stoichiometry: 1.0
species: metaid_0000022
type: SpeciesReference

metaid_0000027
boundary condition: false
is described by: http://identifiers.org/omim/108355
is version of: P62993
constant: false
initial amount: 11000.0
type: Species
initial concentration: NaN
in compartment: metaid_0000005
name: Grb2
has only substance units: true

865424
stoichiometry: 1.0
species: metaid_0000017
type: SpeciesReference

metaid_0000076
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: metaid_0000005
name: Rasi-GTP*
type: Species

metaid_0000233
kinetic law: 861196
product: 861184
product: 861172
reactant: 861160
fast: false
reversible: true
name: v21
type: Reaction

metaid_0000165
constant: true
units: metaid_0000324
value: 1.284
type: Parameter

863795
stoichiometry: 1.0
species: metaid_0000076
type: SpeciesReference

862116
stoichiometry: 1.0
species: metaid_0000038
type: SpeciesReference

863807
stoichiometry: 1.0
species: metaid_0000071
type: SpeciesReference

metaid_0000164
constant: true
units: metaid_0000324
value: 33.0
type: Parameter

864761
stoichiometry: 1.0
species: metaid_0000087
type: SpeciesReference

metaid_0000213
is version of: REACT 9481
kinetic law: 860346
name: v1
reactant: 860310
reversible: true
product: 860334
fast: false
is version of: GO:0005154
type: Reaction
reactant: 860322
is version of: GO:0048408

metaid_0000077
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: metaid_0000005
name: Rafi*
type: Species

864543
stoichiometry: 1.0
species: metaid_0000084
type: SpeciesReference

metaid_0000277
kinetic law: 863265
product: 863253
reactant: 863241
reactant: 863229
fast: false
reversible: true
name: v65
type: Reaction

862491
stoichiometry: 1.0
species: metaid_0000057
type: SpeciesReference

metaid_0000236
kinetic law: 861328
product: 861316
reactant: 861304
reactant: 861292
fast: false
reversible: true
name: v24
type: Reaction

metaid_0000185
constant: true
units: metaid_0000324
value: 3.84
type: Parameter

860732
stoichiometry: 2.0
species: metaid_0000015
type: SpeciesReference

metaid_0000166
constant: true
units: metaid_0000326
value: 0.001
type: Parameter

metaid_0000290
kinetic law: 863879
product: 863867
product: 863855
reactant: 863843
fast: false
reversible: true
name: v78
type: Reaction

metaid_0000009
is version of: REACT 9820
boundary condition: false
initial concentration: NaN
in compartment: metaid_0000005
has only substance units: true
initial amount: 0.0
name: EGF-EGFR^2
type: Species
constant: false
has version: P00533
has version: P01133

metaid_0000271
kinetic law: 863011
product: 862999
product: 862987
reactant: 862975
fast: false
reversible: true
name: v59
type: Reaction

metaid_0000251
kinetic law: 862043
product: 862030
product: 862018
reactant: 862006
fast: false
reversible: true
name: v39
type: Reaction

865122
stoichiometry: 1.0
species: metaid_0000024
type: SpeciesReference

861160
stoichiometry: 1.0
species: metaid_0000034
type: SpeciesReference

860491
stoichiometry: 1.0
species: metaid_0000023
type: SpeciesReference

865086
stoichiometry: 1.0
species: metaid_0000069
type: SpeciesReference

metaid_0000186
constant: true
units: metaid_0000324
value: 2.574
type: Parameter

metaid_0000235
kinetic law: 861280
product: 861268
reactant: 861256
fast: false
reversible: true
name: v23
type: Reaction

metaid_0000167
constant: true
units: metaid_0000326
value: 1.0E-4
type: Parameter

metaid_0000291
kinetic law: 863927
product: 863915
product: 863903
reactant: 863891
fast: false
reversible: true
name: v79
type: Reaction

metaid_0000029
in compartment: metaid_0000005
constant: false
type: Species
is described by: http://identifiers.org/omim/182530
has only substance units: true
boundary condition: false
name: Sos
initial amount: 26300.0
is version of: Q07889
initial concentration: NaN

metaid_0000270
kinetic law: 862963
product: 862951
reactant: 862939
reactant: 862927
fast: false
reversible: true
name: v58
type: Reaction

metaid_0000250
kinetic law: 861994
product: 861982
reactant: 861970
reactant: 861958
fast: false
reversible: true
name: v38
type: Reaction

865460
stoichiometry: 1.0
species: metaid_0000095
type: SpeciesReference

metaid_0000049
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 40000.0
in compartment: metaid_0000005
name: Phosphotase1
type: Species

865736
stoichiometry: 1.0
species: metaid_0000014
type: SpeciesReference

metaid_0000187
constant: true
units: metaid_0000326
value: 0.003
type: Parameter

metaid_0000292
kinetic law: 863975
product: 863963
product: 863951
reactant: 863939
fast: false
reversible: true
name: v80
type: Reaction

metaid_0000168
constant: true
units: metaid_0000324
value: 0.318
type: Parameter

metaid_0000238
kinetic law: 861425
product: 861413
reactant: 861400
reactant: 861388
fast: false
reversible: true
name: v26
type: Reaction

metaid_0000254
kinetic law: 862188
product: 862176
reactant: 862164
reactant: 862152
fast: false
reversible: true
name: v42
type: Reaction

863746
stoichiometry: 1.0
species: metaid_0000075
type: SpeciesReference

861740
stoichiometry: 1.0
species: metaid_0000045
type: SpeciesReference

metaid_0000273
kinetic law: 863083
product: 863071
reactant: 863059
fast: false
reversible: false
name: v61
type: Reaction

861037
stoichiometry: 1.0
species: metaid_0000032
type: SpeciesReference

862539
stoichiometry: 1.0
species: metaid_0000058
type: SpeciesReference

860527
stoichiometry: 1.0
species: metaid_0000007
type: SpeciesReference

864193
stoichiometry: 1.0
species: metaid_0000046
type: SpeciesReference

metaid_0000188
constant: true
units: metaid_0000326
value: 0.0071
type: Parameter

metaid_0000210
constant: true
units: metaid_0000324
value: 18.0
type: Parameter

864785
stoichiometry: 1.0
species: metaid_0000082
type: SpeciesReference

860612
stoichiometry: 1.0
species: metaid_0000019
type: SpeciesReference

metaid_0000293
kinetic law: 864023
product: 864011
product: 863999
reactant: 863987
fast: false
reversible: true
name: v81
type: Reaction

metaid_0000237
kinetic law: 861376
product: 861364
reactant: 861352
reactant: 861340
fast: false
reversible: true
name: v25
type: Reaction

metaid_0000169
constant: true
units: metaid_0000324
value: 60.0
type: Parameter

metaid_0000253
kinetic law: 862140
product: 862128
reactant: 862116
reactant: 862103
fast: false
reversible: true
name: v41
type: Reaction

864567
stoichiometry: 1.0
species: metaid_0000084
type: SpeciesReference

metaid_0000272
kinetic law: 863047
product: 863035
reactant: 863023
fast: false
reversible: false
name: v60
type: Reaction

metaid_0000252
kinetic law: 862091
product: 862079
reactant: 862067
reactant: 862055
fast: false
reversible: true
name: v40
type: Reaction

metaid_0000189
constant: true
units: metaid_0000324
value: 12.0
type: Parameter

865484
stoichiometry: 1.0
species: metaid_0000026
type: SpeciesReference

metaid_0000142
constant: true
units: metaid_0000324
value: 60.0
type: Parameter

865556
stoichiometry: 1.0
species: metaid_0000017
type: SpeciesReference

metaid_0000143
constant: true
units: metaid_0000325
value: 130.2
type: Parameter

865206
stoichiometry: 1.0
species: metaid_0000014
type: SpeciesReference

metaid_0000294
kinetic law: 864072
product: 864059
product: 864047
reactant: 864035
fast: false
reversible: true
name: v82
type: Reaction

862587
stoichiometry: 1.0
species: metaid_0000059
type: SpeciesReference

metaid_0000071
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: metaid_0000005
name: EGF-EGFRi*^2-GAP-Shc*-Grb2-Sos
type: Species

860563
stoichiometry: 1.0
species: metaid_0000010
type: SpeciesReference

metaid_0000181
constant: true
units: metaid_0000321
value: 2.0E14
type: Parameter

metaid_0000005
is: GO:0005737
constant: true
size: 1.0
spatial dimensions: 3.0
name: cytoplasm
type: Compartment

860841
stoichiometry: 1.0
species: metaid_0000019
type: SpeciesReference

metaid_0000098
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: metaid_0000005
name: EGF-EGFR*^2-GAP-Shc*-Grb2-Sos-Ras-GDP-Prot
type: Species

861982
stoichiometry: 1.0
species: metaid_0000044
type: SpeciesReference

865278
stoichiometry: 1.0
species: metaid_0000032
type: SpeciesReference

860225
exponent: 1.0
scale: 0
multipler: 1.0
kind: ITEM
type: SBMLUnit

metaid_0000141
constant: true
units: metaid_0000324
value: 0.6
type: Parameter

metaid_0000219
kinetic law: 860588
product: 860575
reactant: 860563
is version of: GO:0031623
fast: false
reversible: false
name: v7
type: Reaction

861606
stoichiometry: 1.0
species: metaid_0000042
type: SpeciesReference

metaid_0000239
kinetic law: 861474
product: 861461
product: 861449
reactant: 861437
fast: false
reversible: true
name: v27
type: Reaction

metaid_0000070
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: metaid_0000005
name: EGF-EGFRi*^2-GAP-Shc*-Grb2
type: Species

metaid_0000099
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: metaid_0000005
name: EGF-EGFR*^2-GAP-Shc*-Grb2-Sos-Ras-GTP-Prot
type: Species

metaid_0000295
kinetic law: 864120
product: 864108
reactant: 864096
reactant: 864084
fast: false
reversible: true
name: v83
type: Reaction

861703
stoichiometry: 1.0
species: metaid_0000043
type: SpeciesReference

metaid_0000182
constant: true
units: metaid_0000324
value: 18.0
type: Parameter

metaid_0000006
notes: 4962 molecules correspond roughly to 50 ng/ml, concentration used throughout the article (MW~6045 Da, vol=1e-12l)
constant: false
boundary condition: true
has only substance units: true
initial concentration: NaN
initial amount: 4962.0
in compartment: metaid_0000003
name: EGF
type: Species

metaid_0000297
kinetic law: 864217
product: 864205
product: 864193
reactant: 864180
fast: false
reversible: true
name: v85
type: Reaction

metaid_0000097
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: metaid_0000005
name: EGF-EGFR*^2-GAP-Shc*-Grb2-Sos-Prot
type: Species

BIOMD0000000019
parameter: metaid_0000191
reaction: metaid_0000213
reaction: metaid_0000335
parameter: metaid_0000189
parameter: metaid_0000137
species: metaid_0000047
units def: metaid_0000327
parameter: metaid_0000154
reaction: metaid_0000236
parameter: metaid_0000203
reaction: metaid_0000297
reaction: metaid_0000256
parameter: metaid_0000178
reaction: metaid_0000271
species: metaid_0000019
parameter: metaid_0000126
reaction: metaid_0000225
reaction: metaid_0000240
reaction: metaid_0000245
reaction: metaid_0000254
parameter: metaid_0000211
reaction: metaid_0000260
reaction: metaid_0000309
species: metaid_0000054
species: metaid_0000042
species: metaid_0000016
species: metaid_0000083
parameter: metaid_0000160
parameter: metaid_0000149
species: blabla 2
reaction: metaid_0000220
species: metaid_0000035
reaction: metaid_0000336
species: metaid_0000018
species: metaid_0000085
time units: metaid_0000322
reaction: metaid_0000268
parameter: metaid_0000140
reaction: metaid_0000283
parameter: metaid_0000138
is version of: GO:0007173
parameter: metaid_0000164
reaction: metaid_0000331
reaction: metaid_0000237
reaction: metaid_0000257
reaction: metaid_0000266
reaction: metaid_0000272
species: blabla 1
substance units: metaid_0000321
reaction: metaid_0000320
species: metaid_0000071
species: metaid_0000089
parameter: metaid_0000172
reaction: metaid_0000232
species: metaid_0000006
species: metaid_0000073
parameter: metaid_0000152
reaction: metaid_0000295
reaction: metaid_0000221
reaction: metaid_0000343
reaction: metaid_0000305
rule: metaid_0000465
species: metaid_0000070
parameter: metaid_0000141
reaction: metaid_0000269
reaction: metaid_0000278
reaction: metaid_0000284
species: metaid_0000066
species: metaid_0000061
rule: metaid_0000352
reaction: metaid_0000332
species: metaid_0000077
species: metaid_0000072
parameter: metaid_0000184
species: metaid_0000059
species: metaid_0000088
parameter: metaid_0000134
parameter: metaid_0000158
reaction: metaid_0000233
reaction: metaid_0000242

metaid_0000145
constant: true
units: metaid_0000324
value: 12.0
type: Parameter

865604
stoichiometry: 1.0
species: metaid_0000014
type: SpeciesReference

metaid_0000007
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 50000.0
in compartment: metaid_0000003
name: EGFR
type: Species

861012
stoichiometry: 1.0
species: metaid_0000031
type: SpeciesReference

metaid_0000296
kinetic law: 864168
product: 864156
reactant: 864144
reactant: 864132
fast: false
reversible: true
name: v84
type: Reaction

metaid_0000183
constant: true
units: metaid_0000326
value: 9.0E-5
type: Parameter

metaid_0000096
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: metaid_0000005
name: EGF-EGFR*^2-GAP-Shc*-Grb2-Prot
type: Species

863662
stoichiometry: 1.0
species: metaid_0000071
type: SpeciesReference

metaid_0000298
kinetic law: 864265
product: 864253
reactant: 864241
reactant: 864229
fast: false
reversible: true
name: v86
type: Reaction

metaid_0000144
constant: true
units: metaid_0000326
value: 1.0E-4
type: Parameter

metaid_0000008
is version of: REACT 9893
initial concentration: NaN
has version: P00533
boundary condition: false
initial amount: 0.0
constant: false
has only substance units: true
type: Species
has version: P01133
name: EGF-EGFR
in compartment: metaid_0000005

863722
stoichiometry: 1.0
species: metaid_0000075
type: SpeciesReference

860201
exponent: 1.0
scale: -12
multipler: 1.0
kind: LITRE
type: SBMLUnit

862515
stoichiometry: 1.0
species: metaid_0000058
type: SpeciesReference

863325
stoichiometry: 1.0
species: metaid_0000076
type: SpeciesReference

metaid_0000184
constant: true
units: metaid_0000326
value: 0.003
type: Parameter

861728
stoichiometry: 1.0
species: metaid_0000043
type: SpeciesReference

metaid_0000216
kinetic law: 860467
product: 860455
reactant: 860443
reactant: 860430
fast: false
reversible: true
name: v4
type: Reaction

metaid_0000095
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: metaid_0000005
name: EGF-EGFR*^2-GAP-Grb2-Sos-Ras-GTP-Prot
type: Species

metaid_0000299
kinetic law: 864313
product: 864301
product: 864289
reactant: 864277
fast: false
reversible: true
name: v87
type: Reaction

860708
stoichiometry: 1.0
species: metaid_0000015
type: SpeciesReference

metaid_0000075
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: metaid_0000005
name: Rafi-Rasi-GTP
type: Species

862683
stoichiometry: 1.0
species: metaid_0000061
type: SpeciesReference

metaid_0000215
name: v3
is version of: GO:0046777
product: 860406
reactant: 860394
is version of: REACT 9388
reversible: true
is version of: GO:0004713
is version of: GO:0007171
fast: false
type: Reaction
kinetic law: 860418

metaid_0000094
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: metaid_0000005
name: EGF-EGFR*^2-GAP-Grb2-Sos-Ras-GDP-Prot
type: Species

ORG:
  orgname: University of Vienna
n:
  given: Rainer
  family: Machne

863517
stoichiometry: 1.0
species: metaid_0000069
type: SpeciesReference

metaid_0000074
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: metaid_0000005
name: Rasi-GTP
type: Species

865254
stoichiometry: 1.0
species: metaid_0000025
type: SpeciesReference

864495
stoichiometry: 1.0
species: metaid_0000058
type: SpeciesReference

861352
stoichiometry: 1.0
species: metaid_0000039
type: SpeciesReference

864435
stoichiometry: 1.0
species: metaid_0000058
type: SpeciesReference

863613
stoichiometry: 1.0
species: metaid_0000071
type: SpeciesReference

metaid_0000218
kinetic law: 860551
product: 860539
reactant: 860527
is version of: GO:0031623
fast: false
reversible: true
name: v6
type: Reaction

862406
stoichiometry: 1.0
species: metaid_0000056
type: SpeciesReference

metaid_0000140
constant: true
units: metaid_0000326
value: 0.001
type: Parameter

ORG:
  orgname: EMBL-EBI
n:
  given: Lukas
  family: Endler

metaid_0000093
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: metaid_0000005
name: EGF-EGFR*^2-GAP-Grb2-Sos-Prot
type: Species

metaid_0000073
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: metaid_0000005
name: EGF-EGFRi*^2-GAP-Shc*-Grb2-Sos-Ras-GTP
type: Species

metaid_0000003
is: GO:0005615
constant: true
size: 1.0
spatial dimensions: 3.0
name: extracellular volume
type: Compartment

862006
stoichiometry: 1.0
species: metaid_0000039
type: SpeciesReference

865592
stoichiometry: 1.0
species: metaid_0000096
type: SpeciesReference

metaid_0000217
kinetic law: 860515
product: 860503
product: 860491
reactant: 860479
fast: false
reversible: true
name: v5
type: Reaction

863301
stoichiometry: 1.0
species: metaid_0000024
type: SpeciesReference

metaid_0000160
constant: true
units: metaid_0000324
value: 6.0
type: Parameter

metaid_0000092
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: metaid_0000005
name: EGF-EGFRi*^2deg
type: Species

metaid_0000180
constant: true
units: metaid_0000325
value: 61200.0
type: Parameter

metaid_0000004
is: GO:0005768
constant: true
size: 4.3E-6
spatial dimensions: 3.0
name: endosomal volume
type: Compartment

862793
stoichiometry: 1.0
species: metaid_0000064
type: SpeciesReference

862939
stoichiometry: 1.0
species: metaid_0000062
type: SpeciesReference

metaid_0000072
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: metaid_0000005
name: EGF-EGFRi*^2-GAP-Shc*-Grb2-Sos-Ras-GDP
type: Species

860976
stoichiometry: 1.0
species: metaid_0000028
type: SpeciesReference

864156
stoichiometry: 1.0
species: metaid_0000078
type: SpeciesReference

861691
stoichiometry: 1.0
species: metaid_0000020
type: SpeciesReference

860430
stoichiometry: 1.0
species: metaid_0000028
type: SpeciesReference

metaid_0000138
constant: true
units: metaid_0000324
value: 0.66
type: Parameter

blabla 4
constant: false
boundary condition: true
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: metaid_0000005
name: t_ERK_PP
type: Species

865904
stoichiometry: 1.0
species: metaid_0000042
type: SpeciesReference

862805
stoichiometry: 1.0
species: metaid_0000056
type: SpeciesReference

metaid_0000090
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: metaid_0000005
name: ERKi-P-P'ase3i
type: Species

865351
stoichiometry: 1.0
species: metaid_0000025
type: SpeciesReference

861594
stoichiometry: 1.0
species: metaid_0000048
type: SpeciesReference

864712
stoichiometry: 1.0
species: metaid_0000082
type: SpeciesReference

863433
stoichiometry: 1.0
species: metaid_0000022
type: SpeciesReference

blabla 3
constant: false
boundary condition: true
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: metaid_0000005
name: t_MEK_PP
type: Species

metaid_0000139
constant: true
units: metaid_0000324
value: 6.0
type: Parameter

861922
stoichiometry: 1.0
species: metaid_0000020
type: SpeciesReference

861087
stoichiometry: 1.0
species: metaid_0000030
type: SpeciesReference

864627
stoichiometry: 1.0
species: metaid_0000082
type: SpeciesReference

metaid_0000091
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: metaid_0000005
name: EGFRideg
type: Species

862369
stoichiometry: 1.0
species: metaid_0000055
type: SpeciesReference

metaid_0000050
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: metaid_0000005
name: Raf*
type: Species

blabla 2
constant: false
boundary condition: true
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: metaid_0000005
name: t_Ras_GTP
type: Species

metaid_0000012
type: Species
boundary condition: false
initial concentration: NaN
has only substance units: true
has version: GO:0030119
has version: P00533
name: EGF-EGFR*^2-GAP-Grb2-Prot
has version: P20936
initial amount: 0.0
in compartment: metaid_0000005
constant: false
has version: P62993
has version: P01133

861486
stoichiometry: 1.0
species: metaid_0000033
type: SpeciesReference

864059
stoichiometry: 1.0
species: metaid_0000044
type: SpeciesReference

860940
stoichiometry: 1.0
species: metaid_0000028
type: SpeciesReference

864387
stoichiometry: 1.0
species: metaid_0000077
type: SpeciesReference

865676
stoichiometry: 1.0
species: metaid_0000040
type: SpeciesReference

863023
stoichiometry: 1.0
species: metaid_0000011
type: SpeciesReference

863855
stoichiometry: 1.0
species: metaid_0000071
type: SpeciesReference

863241
stoichiometry: 1.0
species: metaid_0000024
type: SpeciesReference

864737
stoichiometry: 1.0
species: metaid_0000087
type: SpeciesReference

metaid_0000051
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: metaid_0000005
name: Raf*-P'ase
type: Species

864470
stoichiometry: 1.0
species: metaid_0000083
type: SpeciesReference

blabla 1
constant: false
boundary condition: true
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: metaid_0000005
name: t_Raf*
type: Species

metaid_0000011
is version of: P00533
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: metaid_0000005
name: EGFRi
type: Species

862055
stoichiometry: 1.0
species: metaid_0000029
type: SpeciesReference

860928
stoichiometry: 1.0
species: metaid_0000020
type: SpeciesReference

metaid_0000010
is version of: C00562
has version: P00533
constant: false
has version: P01133
type: Species
initial concentration: NaN
in compartment: metaid_0000005
name: EGF-EGFR*^2
boundary condition: false
initial amount: 0.0
has only substance units: true

860250
exponent: -1.0
scale: 0
multipler: 60.0
kind: SECOND
type: SBMLUnit

865388
stoichiometry: 1.0
species: metaid_0000026
type: SpeciesReference

864096
stoichiometry: 1.0
species: metaid_0000069
type: SpeciesReference

861643
stoichiometry: 1.0
species: metaid_0000040
type: SpeciesReference

metaid_0000134
constant: true
units: metaid_0000324
value: 0.003
type: Parameter

864277
stoichiometry: 1.0
species: metaid_0000079
type: SpeciesReference

863192
stoichiometry: 1.0
species: metaid_0000023
type: SpeciesReference

862212
stoichiometry: 1.0
species: metaid_0000046
type: SpeciesReference

860322
stoichiometry: 1.0
species: metaid_0000007
type: SpeciesReference

865508
stoichiometry: 1.0
species: metaid_0000039
type: SpeciesReference

metaid_0000336
kinetic law: 865664
product: 865652
reactant: 865640
fast: false
reversible: true
name: v117
type: Reaction

865376
stoichiometry: 1.0
species: metaid_0000034
type: SpeciesReference

metaid_0000135
constant: true
units: metaid_0000326
value: 1.0E-4
type: Parameter

865820
stoichiometry: 1.0
species: metaid_0000017
type: SpeciesReference

metaid_0000337
kinetic law: 865712
product: 865700
reactant: 865688
reactant: 865676
fast: false
reversible: true
name: v118
type: Reaction

860964
stoichiometry: 1.0
species: metaid_0000029
type: SpeciesReference

metaid_0000136
constant: true
units: metaid_0000324
value: 12.0
type: Parameter

865652
stoichiometry: 1.0
species: metaid_0000071
type: SpeciesReference

862951
stoichiometry: 1.0
species: metaid_0000067
type: SpeciesReference

862164
stoichiometry: 1.0
species: metaid_0000050
type: SpeciesReference

metaid_0000338
kinetic law: 865760
product: 865748
product: 865736
reactant: 865724
fast: false
reversible: true
name: v119
type: Reaction

metaid_0000311
kinetic law: 864894
product: 864882
product: 864870
reactant: 864858
fast: false
reversible: true
name: v99
type: Reaction

864688
stoichiometry: 1.0
species: metaid_0000082
type: SpeciesReference

864870
stoichiometry: 1.0
species: metaid_0000086
type: SpeciesReference

862563
stoichiometry: 1.0
species: metaid_0000059
type: SpeciesReference

metaid_0000137
constant: true
units: metaid_0000326
value: 3.25581
type: Parameter

864821
stoichiometry: 1.0
species: metaid_0000065
type: SpeciesReference

862018
stoichiometry: 1.0
species: metaid_0000020
type: SpeciesReference

metaid_0000310
kinetic law: 864846
product: 864834
reactant: 864821
reactant: 864809
fast: false
reversible: true
name: v98
type: Reaction

metaid_0000339
kinetic law: 865796
product: 865784
reactant: 865772
fast: false
reversible: true
name: v120
type: Reaction

864301
stoichiometry: 1.0
species: metaid_0000077
type: SpeciesReference

863397
stoichiometry: 1.0
species: metaid_0000031
type: SpeciesReference

862079
stoichiometry: 1.0
species: metaid_0000043
type: SpeciesReference

metaid_0000332
kinetic law: 865496
product: 865484
product: 865472
reactant: 865460
fast: false
reversible: true
name: v113
type: Reaction

metaid_0000351
constant: false
value: NaN
name: C_internalization
type: Parameter

862321
stoichiometry: 1.0
species: metaid_0000050
type: SpeciesReference

866012
stoichiometry: 1.0
species: metaid_0000014
type: SpeciesReference

metaid_0000057
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: metaid_0000005
name: MEK-PP-P'ase2
type: Species

metaid_0000313
kinetic law: 864990
product: 864978
product: 864966
reactant: 864954
is described by: http://identifiers.org/omim/164760
fast: false
reversible: true
name: v101
type: Reaction

metaid_0000243
kinetic law: 861667
product: 861655
product: 861643
reactant: 861631
fast: false
reversible: true
name: v31
type: Reaction

861461
stoichiometry: 1.0
species: metaid_0000033
type: SpeciesReference

863481
stoichiometry: 1.0
species: metaid_0000069
type: SpeciesReference

865170
stoichiometry: 1.0
species: metaid_0000093
type: SpeciesReference

metaid_0000159
constant: true
units: metaid_0000326
value: 0.0021
type: Parameter

860479
stoichiometry: 1.0
species: metaid_0000012
type: SpeciesReference

861534
stoichiometry: 1.0
species: metaid_0000047
type: SpeciesReference

862635
stoichiometry: 1.0
species: metaid_0000060
type: SpeciesReference

metaid_0000333
kinetic law: 865532
product: 865520
reactant: 865508
fast: false
reversible: true
name: v114
type: Reaction

865784
stoichiometry: 1.0
species: metaid_0000072
type: SpeciesReference

862611
stoichiometry: 1.0
species: metaid_0000058
type: SpeciesReference

metaid_0000312
kinetic law: 864942
product: 864930
reactant: 864918
reactant: 864906
is described by: http://identifiers.org/omim/164760
fast: false
reversible: true
name: v100
type: Reaction

metaid_0000058
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 40000.0
in compartment: metaid_0000005
name: Phosphatase2
type: Species

metaid_0000244
kinetic law: 861715
product: 861703
product: 861691
reactant: 861679
fast: false
reversible: true
name: v32
type: Reaction

863565
stoichiometry: 1.0
species: metaid_0000070
type: SpeciesReference

metaid_0000353
constant: true
units: metaid_0000321
value: 50000.0
name: total_Receptors
type: Parameter

864253
stoichiometry: 1.0
species: metaid_0000079
type: SpeciesReference

861304
stoichiometry: 1.0
species: metaid_0000038
type: SpeciesReference

861268
stoichiometry: 1.0
species: metaid_0000038
type: SpeciesReference

metaid_0000158
constant: true
units: metaid_0000326
value: 2.2E-5
type: Parameter

864531
stoichiometry: 1.0
species: metaid_0000080
type: SpeciesReference

metaid_0000334
kinetic law: 865580
product: 865568
reactant: 865556
reactant: 865544
fast: false
reversible: true
name: v115
type: Reaction

863289
stoichiometry: 1.0
species: metaid_0000074
type: SpeciesReference

863373
stoichiometry: 1.0
species: metaid_0000026
type: SpeciesReference

metaid_0000315
kinetic law: 865062
product: 865050
reactant: 865038
fast: false
reversible: true
name: v103
type: Reaction

863939
stoichiometry: 1.0
species: metaid_0000024
type: SpeciesReference

863987
stoichiometry: 1.0
species: metaid_0000069
type: SpeciesReference

864325
stoichiometry: 1.0
species: metaid_0000077
type: SpeciesReference

865002
stoichiometry: 1.0
species: metaid_0000020
type: SpeciesReference

metaid_0000059
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: metaid_0000005
name: MEK-P-P'ase2
type: Species

metaid_0000030
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: metaid_0000005
name: EGF-EGFR*^2-GAP-Grb2-Sos
type: Species

864918
stoichiometry: 1.0
species: metaid_0000086
type: SpeciesReference

metaid_0000245
kinetic law: 861764
product: 861752
product: 861740
reactant: 861728
fast: false
reversible: true
name: v33
type: Reaction

860298
exponent: -1.0
scale: 0
multipler: 60.0
kind: SECOND
type: SBMLUnit

metaid_0000335
kinetic law: 865628
product: 865616
product: 865604
reactant: 865592
fast: false
reversible: true
name: v116
type: Reaction

862975
stoichiometry: 1.0
species: metaid_0000067
type: SpeciesReference

metaid_0000314
kinetic law: 865026
product: 865014
reactant: 865002
fast: false
reversible: true
name: v102
type: Reaction

metaid_0000031
initial amount: 72000.0
has part: CHEBI:17552
name: Ras-GDP
has only substance units: true
constant: false
type: Species
boundary condition: false
initial concentration: NaN
has part: P01112
in compartment: metaid_0000005

metaid_0000246
kinetic law: 861813
product: 861801
product: 861789
reactant: 861777
fast: false
reversible: true
name: v34
type: Reaction

863229
stoichiometry: 1.0
species: metaid_0000031
type: SpeciesReference

864930
stoichiometry: 1.0
species: metaid_0000090
type: SpeciesReference

863155
stoichiometry: 1.0
species: metaid_0000023
type: SpeciesReference

metaid_0000267
kinetic law: 862817
product: 862805
product: 862793
reactant: 862781
fast: false
reversible: true
name: v55
type: Reaction

865242
stoichiometry: 1.0
species: metaid_0000032
type: SpeciesReference

metaid_0000032
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: metaid_0000005
name: EGF-EGFR*^2-GAP-Grb2-Sos-Ras-GDP
type: Species

865194
stoichiometry: 1.0
species: metaid_0000093
type: SpeciesReference

865748
stoichiometry: 1.0
species: metaid_0000071
type: SpeciesReference

metaid_0000317
kinetic law: 865134
product: 865122
reactant: 865110
fast: false
reversible: true
name: v105
type: Reaction

860455
stoichiometry: 1.0
species: metaid_0000012
type: SpeciesReference

865868
stoichiometry: 1.0
species: metaid_0000014
type: SpeciesReference

861510
stoichiometry: 1.0
species: metaid_0000047
type: SpeciesReference

862345
stoichiometry: 1.0
species: metaid_0000054
type: SpeciesReference

metaid_0000052
in compartment: metaid_0000005
is described by: http://identifiers.org/omim/176872
type: Species
is version of: Q02750
boundary condition: false
name: MEK
has only substance units: true
initial concentration: NaN
initial amount: 2.2E7
constant: false
is version of: A4QPA9

metaid_0000033
has only substance units: true
has part: CHEBI:15996
constant: false
boundary condition: false
type: Species
in compartment: metaid_0000005
name: Ras-GTP
initial concentration: NaN
initial amount: 0.0
has part: P01112

metaid_0000247
kinetic law: 861861
product: 861849
product: 861837
reactant: 861825
fast: false
reversible: true
name: v35
type: Reaction

metaid_0000268
kinetic law: 862867
product: 862855
reactant: 862843
reactant: 862830
fast: false
reversible: true
name: v56
type: Reaction

metaid_0000316
kinetic law: 865098
product: 865086
reactant: 865074
fast: false
reversible: true
name: v104
type: Reaction

862659
stoichiometry: 1.0
species: metaid_0000061
type: SpeciesReference

metaid_0000053
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: metaid_0000005
name: MEK-Raf*
type: Species

metaid_0000248
kinetic law: 861898
product: 861886
reactant: 861874
fast: false
reversible: false
name: v36
type: Reaction

metaid_0000034
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: metaid_0000005
name: EGF-EGFR*^2-GAP-Grb2-Sos-Ras-GTP
type: Species

metaid_0000055
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: metaid_0000005
name: MEK-P-Raf*
type: Species

metaid_0000269
kinetic law: 862915
product: 862903
product: 862891
reactant: 862879
fast: false
reversible: true
name: v57
type: Reaction

864349
stoichiometry: 1.0
species: metaid_0000081
type: SpeciesReference

863963
stoichiometry: 1.0
species: metaid_0000035
type: SpeciesReference

metaid_0000240
kinetic law: 861522
product: 861510
reactant: 861498
reactant: 861486
fast: false
reversible: true
name: v28
type: Reaction

860274
exponent: 1.0
scale: -12
multipler: 1.0
kind: LITRE
type: SBMLUnit

metaid_0000319
kinetic law: 865230
product: 865218
product: 865206
reactant: 865194
fast: false
reversible: true
name: v107
type: Reaction

metaid_0000330
kinetic law: 865400
product: 865388
reactant: 865376
fast: false
reversible: true
name: v111
type: Reaction

863915
stoichiometry: 1.0
species: metaid_0000043
type: SpeciesReference

blabla 6
constant: false
boundary condition: true
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: metaid_0000005
name: t_EGF_EGFR*
type: Species

metaid_0000249
kinetic law: 861946
product: 861934
product: 861922
reactant: 861910
fast: false
reversible: true
name: v37
type: Reaction

metaid_0000035
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 40000.0
in compartment: metaid_0000005
name: Grb2-Sos
type: Species

metaid_0000054
type: Species
in compartment: metaid_0000005
is version of: A4QPA9
is version of: Q02750
boundary condition: false
initial amount: 0.0
name: MEK-P
has only substance units: true
is version of: C00562
initial concentration: NaN
constant: false
is described by: http://identifiers.org/omim/176872

865952
stoichiometry: 1.0
species: metaid_0000017
type: SpeciesReference

metaid_0000056
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: metaid_0000005
name: MEK-PP
type: Species

863131
stoichiometry: 1.0
species: metaid_0000022
type: SpeciesReference

metaid_0000241
kinetic law: 861570
product: 861558
product: 861546
reactant: 861534
fast: false
reversible: true
name: v29
type: Reaction

metaid_0000331
kinetic law: 865448
product: 865436
reactant: 865424
reactant: 865412
fast: false
reversible: true
name: v112
type: Reaction

metaid_0000318
kinetic law: 865182
product: 865170
reactant: 865158
reactant: 865146
fast: false
reversible: true
name: v106
type: Reaction

862999
stoichiometry: 1.0
species: metaid_0000065
type: SpeciesReference

metaid_0000242
kinetic law: 861618
product: 861606
reactant: 861594
reactant: 861582
fast: false
reversible: true
name: v30
type: Reaction

864809
stoichiometry: 1.0
species: metaid_0000088
type: SpeciesReference

862030
stoichiometry: 1.0
species: metaid_0000044
type: SpeciesReference

blabla 5
constant: false
boundary condition: true
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: metaid_0000005
name: t_SHC_P_t
type: Species

metaid_0000036
initial concentration: NaN
is described by: http://identifiers.org/omim/605217
name: Shc
in compartment: metaid_0000005
has only substance units: true
is version of: P98077
boundary condition: false
initial amount: 101000.0
constant: false
type: Species

864954
stoichiometry: 1.0
species: metaid_0000090
type: SpeciesReference

863770
stoichiometry: 1.0
species: metaid_0000077
type: SpeciesReference

metaid_0000176
constant: true
units: metaid_0000326
value: 4.5E-4
type: Parameter

metaid_0000222
kinetic law: 860720
product: 860708
reactant: 860696
reactant: 860684
is version of: GO:0031623
fast: false
reversible: true
name: v10
type: Reaction

863698
stoichiometry: 1.0
species: metaid_0000074
type: SpeciesReference

862855
stoichiometry: 1.0
species: metaid_0000066
type: SpeciesReference

861752
stoichiometry: 1.0
species: metaid_0000035
type: SpeciesReference

863758
stoichiometry: 1.0
species: metaid_0000076
type: SpeciesReference

metaid_0000261
kinetic law: 862527
product: 862515
product: 862503
reactant: 862491
fast: false
reversible: true
name: v49
type: Reaction

862103
stoichiometry: 1.0
species: metaid_0000035
type: SpeciesReference

metaid_0000175
constant: true
units: metaid_0000324
value: 1.8
type: Parameter

metaid_0000202
constant: true
units: metaid_0000324
value: 1.98
type: Parameter

metaid_0000221
kinetic law: 860672
product: 860660
reactant: 860648
fast: false
reversible: false
name: v9
type: Reaction

metaid_0000177
constant: true
units: metaid_0000324
value: 0.09
type: Parameter

W3 CDTF: Mon Aug 15 07:36:38 BST 2005

864035
stoichiometry: 1.0
species: metaid_0000070
type: SpeciesReference

metaid_0000039
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: metaid_0000005
name: EGF-EGFR*^2-GAP-Shc*-Grb2
type: Species

865412
stoichiometry: 1.0
species: metaid_0000034
type: SpeciesReference

metaid_0000289
kinetic law: 863831
product: 863819
reactant: 863807
reactant: 863795
fast: false
reversible: true
name: v77
type: Reaction

metaid_0000260
kinetic law: 862479
product: 862467
reactant: 862455
reactant: 862443
fast: false
reversible: true
name: v48
type: Reaction

metaid_0000201
constant: true
units: metaid_0000326
value: 0.00534
type: Parameter

863819
stoichiometry: 1.0
species: metaid_0000073
type: SpeciesReference

863204
stoichiometry: 1.0
species: metaid_0000024
type: SpeciesReference

864773
stoichiometry: 1.0
species: metaid_0000088
type: SpeciesReference

metaid_0000089
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: metaid_0000005
name: ERKi-PP-P'ase3i
type: Species

861777
stoichiometry: 1.0
species: metaid_0000030
type: SpeciesReference

861135
stoichiometry: 1.0
species: metaid_0000034
type: SpeciesReference

metaid_0000220
kinetic law: 860636
product: 860624
reactant: 860612
reactant: 860600
fast: false
reversible: true
name: v8
type: Reaction

865158
stoichiometry: 1.0
species: metaid_0000017
type: SpeciesReference

metaid_0000038
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: metaid_0000005
name: EGF-EGFR*^2-GAP-Shc*
type: Species

861413
stoichiometry: 1.0
species: metaid_0000041
type: SpeciesReference

865808
stoichiometry: 1.0
species: metaid_0000041
type: SpeciesReference

metaid_0000288
kinetic law: 863782
product: 863770
product: 863758
reactant: 863746
fast: false
reversible: true
name: v76
type: Reaction

865327
stoichiometry: 1.0
species: metaid_0000094
type: SpeciesReference

864663
stoichiometry: 1.0
species: metaid_0000085
type: SpeciesReference

metaid_0000173
constant: true
units: metaid_0000324
value: 12.0
type: Parameter

860684
stoichiometry: 1.0
species: metaid_0000011
type: SpeciesReference

861825
stoichiometry: 1.0
species: metaid_0000035
type: SpeciesReference

860406
stoichiometry: 1.0
species: metaid_0000010
type: SpeciesReference

860780
stoichiometry: 1.0
species: metaid_0000013
type: SpeciesReference

metaid_0000037
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: metaid_0000005
name: EGF-EGFR*^2-GAP-Shc
type: Species

865700
stoichiometry: 1.0
species: metaid_0000097
type: SpeciesReference

metaid_0000287
kinetic law: 863734
product: 863722
reactant: 863710
reactant: 863698
fast: false
reversible: true
name: v75
type: Reaction

metaid_0000174
constant: true
units: metaid_0000326
value: 0.0021
type: Parameter

862467
stoichiometry: 1.0
species: metaid_0000057
type: SpeciesReference

860804
stoichiometry: 1.0
species: metaid_0000007
type: SpeciesReference

metaid_0000266
kinetic law: 862769
product: 862757
reactant: 862745
reactant: 862732
fast: false
reversible: true
name: v54
type: Reaction

861232
stoichiometry: 1.0
species: metaid_0000037
type: SpeciesReference

metaid_0000285
kinetic law: 863638
product: 863625
reactant: 863613
reactant: 863601
fast: false
reversible: true
name: v73
type: Reaction

862879
stoichiometry: 1.0
species: metaid_0000066
type: SpeciesReference

metaid_0000226
kinetic law: 860865
product: 860853
reactant: 860841
reactant: 860829
fast: false
reversible: true
name: v14
type: Reaction

metaid_0000286
kinetic law: 863686
product: 863674
product: 863662
reactant: 863650
fast: false
reversible: true
name: v74
type: Reaction

metaid_0000265
kinetic law: 862719
product: 862707
product: 862695
reactant: 862683
fast: false
reversible: true
name: v53
type: Reaction

865302
stoichiometry: 1.0
species: metaid_0000094
type: SpeciesReference

864579
stoichiometry: 1.0
species: metaid_0000052
type: SpeciesReference

metaid_0000284
kinetic law: 863589
product: 863577
reactant: 863565
reactant: 863553
fast: false
reversible: true
name: v72
type: Reaction

864519
stoichiometry: 1.0
species: metaid_0000058
type: SpeciesReference

860600
stoichiometry: 1.0
species: metaid_0000010
type: SpeciesReference

metaid_0000225
kinetic law: 860816
product: 860804
fast: false
reversible: false
name: v13
type: Reaction

863891
stoichiometry: 1.0
species: metaid_0000071
type: SpeciesReference

866000
stoichiometry: 1.0
species: metaid_0000073
type: SpeciesReference

862128
stoichiometry: 1.0
species: metaid_0000040
type: SpeciesReference

864011
stoichiometry: 1.0
species: metaid_0000045
type: SpeciesReference

861849
stoichiometry: 1.0
species: metaid_0000027
type: SpeciesReference

metaid_0000283
kinetic law: 863541
product: 863529
reactant: 863517
reactant: 863505
fast: false
reversible: true
name: v71
type: Reaction

metaid_0000264
kinetic law: 862671
product: 862659
reactant: 862647
reactant: 862635
fast: false
reversible: true
name: v52
type: Reaction

metaid_0000197
constant: true
units: metaid_0000324
value: 3.48
type: Parameter

metaid_0000224
kinetic law: 860792
product: 860780
reactant: 860768
fast: false
reversible: true
name: v12
type: Reaction

860660
stoichiometry: 1.0
species: metaid_0000023
type: SpeciesReference

860744
stoichiometry: 1.0
species: metaid_0000016
type: SpeciesReference

metaid_0000308
kinetic law: 864749
product: 864737
reactant: 864724
reactant: 864712
fast: false
reversible: true
name: v96
type: Reaction

860829
stoichiometry: 1.0
species: metaid_0000013
type: SpeciesReference

metaid_0000178
constant: true
units: metaid_0000326
value: 4.5E-4
type: Parameter

861172
stoichiometry: 1.0
species: metaid_0000030
type: SpeciesReference

metaid_0000198
constant: true
units: metaid_0000324
value: 30.0
type: Parameter

865074
stoichiometry: 1.0
species: metaid_0000038
type: SpeciesReference

metaid_0000263
kinetic law: 862623
product: 862611
product: 862599
reactant: 862587
fast: false
reversible: true
name: v51
type: Reaction

865110
stoichiometry: 1.0
species: metaid_0000030
type: SpeciesReference

metaid_0000282
kinetic law: 863493
product: 863481
reactant: 863469
fast: false
reversible: true
name: v70
type: Reaction

860575
stoichiometry: 1.0
species: metaid_0000013
type: SpeciesReference

metaid_0000309
kinetic law: 864797
product: 864785
product: 864773
reactant: 864761
fast: false
reversible: true
name: v97
type: Reaction

metaid_0000223
kinetic law: 860756
product: 860744
reactant: 860732
fast: false
reversible: true
name: v11
type: Reaction

865218
stoichiometry: 1.0
species: metaid_0000024
type: SpeciesReference

metaid_0000199
constant: true
units: metaid_0000326
value: 2.5E-5
type: Parameter

861886
stoichiometry: 1.0
species: metaid_0000036
type: SpeciesReference

metaid_0000262
kinetic law: 862575
product: 862563
reactant: 862551
reactant: 862539
fast: false
reversible: true
name: v50
type: Reaction

864180
stoichiometry: 1.0
species: metaid_0000078
type: SpeciesReference

861449
stoichiometry: 1.0
species: metaid_0000040
type: SpeciesReference

865724
stoichiometry: 1.0
species: metaid_0000097
type: SpeciesReference

865616
stoichiometry: 1.0
species: metaid_0000070
type: SpeciesReference

metaid_0000081
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: metaid_0000005
name: MEKi-P-Rafi*
type: Species

metaid_0000195
constant: true
units: metaid_0000324
value: 48.0
type: Parameter

metaid_0000157
constant: true
units: metaid_0000324
value: 1.38
type: Parameter

860890
stoichiometry: 1.0
species: metaid_0000017
type: SpeciesReference

metaid_0000281
kinetic law: 863457
product: 863445
reactant: 863433
reactant: 863421
fast: false
reversible: true
name: v69
type: Reaction

864423
stoichiometry: 1.0
species: metaid_0000082
type: SpeciesReference

863625
stoichiometry: 1.0
species: metaid_0000072
type: SpeciesReference

860624
stoichiometry: 1.0
species: metaid_0000020
type: SpeciesReference

metaid_0000019
constant: false
is version of: IPR001936
is version of: P20936
boundary condition: false
in compartment: metaid_0000005
has only substance units: true
initial concentration: NaN
initial amount: 12000.0
is described by: http://identifiers.org/omim/139150
name: GAP
type: Species

metaid_0000209
constant: true
units: metaid_0000326
value: 5.0E-4
type: Parameter

863650
stoichiometry: 1.0
species: metaid_0000072
type: SpeciesReference

863337
stoichiometry: 1.0
species: metaid_0000024
type: SpeciesReference

863710
stoichiometry: 1.0
species: metaid_0000046
type: SpeciesReference

860213
exponent: -1.0
scale: 0
multipler: 60.0
kind: SECOND
type: SBMLUnit

861025
stoichiometry: 1.0
species: metaid_0000030
type: SpeciesReference

metaid_0000080
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: metaid_0000005
name: MEKi-P
type: Species

metaid_0000196
constant: true
units: metaid_0000326
value: 0.00143
type: Parameter

metaid_0000280
kinetic law: 863409
product: 863397
product: 863385
reactant: 863373
fast: false
reversible: true
name: v68
type: Reaction

metaid_0000156
constant: true
units: metaid_0000326
value: 2.1E-4
type: Parameter

metaid_0000229
kinetic law: 861000
product: 860988
reactant: 860976
reactant: 860964
fast: false
reversible: true
name: v17
type: Reaction

865544
stoichiometry: 1.0
species: metaid_0000039
type: SpeciesReference

metaid_0000208
constant: true
units: metaid_0000324
value: 30.0
type: Parameter

865472
stoichiometry: 1.0
species: metaid_0000014
type: SpeciesReference

metaid_0000083
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: metaid_0000005
name: MEKi-PP-P'ase2i
type: Species

862599
stoichiometry: 1.0
species: metaid_0000052
type: SpeciesReference

860853
stoichiometry: 1.0
species: metaid_0000022
type: SpeciesReference

metaid_0000017
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 81000.0
in compartment: metaid_0000005
name: Prot
type: Species

metaid_0000193
constant: true
units: metaid_0000324
value: 210.0
type: Parameter

metaid_0000228
kinetic law: 860952
product: 860940
reactant: 860928
reactant: 860915
fast: false
reversible: true
name: v16
type: Reaction

metaid_0000155
constant: true
units: metaid_0000324
value: 24.0
type: Parameter

860237
exponent: -1.0
scale: 0
multipler: 60.0
kind: SECOND
type: SBMLUnit

861970
stoichiometry: 1.0
species: metaid_0000045
type: SpeciesReference

metaid_0000153
constant: true
units: metaid_0000326
value: 1.0E-5
type: Parameter

861558
stoichiometry: 1.0
species: metaid_0000050
type: SpeciesReference

861364
stoichiometry: 1.0
species: metaid_0000040
type: SpeciesReference

metaid_0000207
constant: true
units: metaid_0000324
value: 16.2
type: Parameter

metaid_0000194
constant: true
units: metaid_0000324
value: 174.0
type: Parameter

metaid_0000227
kinetic law: 860902
product: 860890
reactant: 860877
fast: false
reversible: false
name: v15
type: Reaction

863059
stoichiometry: 1.0
species: metaid_0000021
type: SpeciesReference

metaid_0000082
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: metaid_0000005
name: MEKi-PP
type: Species

865880
stoichiometry: 1.0
species: metaid_0000072
type: SpeciesReference

metaid_0000018
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: metaid_0000004
name: EGFideg
type: Species

862695
stoichiometry: 1.0
species: metaid_0000056
type: SpeciesReference

862273
stoichiometry: 1.0
species: metaid_0000053
type: SpeciesReference

860768
stoichiometry: 1.0
species: metaid_0000016
type: SpeciesReference

metaid_0000154
constant: true
units: metaid_0000324
value: 30.0
type: Parameter

metaid_0000171
constant: true
units: metaid_0000326
value: 2.4E-5
type: Parameter

metaid_0000206
constant: true
units: metaid_0000326
value: 0.00145
type: Parameter

863601
stoichiometry: 1.0
species: metaid_0000031
type: SpeciesReference

metaid_0000133
constant: true
units: metaid_0000324
value: 0.3
type: Parameter

metaid_0000152
constant: true
units: metaid_0000326
value: 0.0015
type: Parameter

860648
stoichiometry: 1.0
species: metaid_0000028
type: SpeciesReference

metaid_0000191
constant: true
units: metaid_0000324
value: 1.0998
type: Parameter

metaid_0000015
in compartment: metaid_0000005
initial amount: 0.0
initial concentration: NaN
boundary condition: false
has version: P00533
has only substance units: true
name: EGF-EGFRi
has version: P01133
constant: false
type: Species

metaid_0000085
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: metaid_0000005
name: ERKi-MEKi-PP
type: Species

862830
stoichiometry: 1.0
species: metaid_0000064
type: SpeciesReference

864858
stoichiometry: 1.0
species: metaid_0000089
type: SpeciesReference

862503
stoichiometry: 1.0
species: metaid_0000054
type: SpeciesReference

metaid_0000172
constant: true
units: metaid_0000324
value: 6.0
type: Parameter

metaid_0000205
constant: true
units: metaid_0000324
value: 36.0
type: Parameter

metaid_0000132
constant: true
units: metaid_0000324
value: 0.003
type: Parameter

864446
stoichiometry: 1.0
species: metaid_0000083
type: SpeciesReference

862745
stoichiometry: 1.0
species: metaid_0000062
type: SpeciesReference

862419
stoichiometry: 1.0
species: metaid_0000050
type: SpeciesReference

metaid_0000151
constant: true
units: metaid_0000324
value: 78.0
type: Parameter

860988
stoichiometry: 1.0
species: metaid_0000030
type: SpeciesReference

865916
stoichiometry: 1.0
species: metaid_0000073
type: SpeciesReference

864144
stoichiometry: 1.0
species: metaid_0000077
type: SpeciesReference

metaid_0000131
constant: false
units: metaid_0000324
value: NaN
type: Parameter

metaid_0000084
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: metaid_0000005
name: MEKi-P-P'ase2i
type: Species

862781
stoichiometry: 1.0
species: metaid_0000063
type: SpeciesReference

metaid_0000016
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: metaid_0000005
name: EGF-EGFRi^2
type: Species

metaid_0000192
constant: true
units: metaid_0000326
value: 0.00111
type: Parameter

863674
stoichiometry: 1.0
species: metaid_0000074
type: SpeciesReference

860877
stoichiometry: 1.0
species: metaid_0000014
type: SpeciesReference

metaid_0000204
constant: true
units: metaid_0000324
value: 342.0
type: Parameter

metaid_0000088
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: metaid_0000005
name: ERKi-PP
type: Species

metaid_0000150
constant: true
units: metaid_0000326
value: 0.001
type: Parameter

metaid_0000130
constant: true
units: metaid_0000324
value: 0.0996
type: Parameter

865520
stoichiometry: 1.0
species: metaid_0000070
type: SpeciesReference

metaid_0000013
initial concentration: NaN
has version: P00533
has version: P01133
name: EGF-EGFRi*^2
type: Species
initial amount: 0.0
constant: false
boundary condition: false
in compartment: metaid_0000005
has only substance units: true

metaid_0000087
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: metaid_0000005
name: ERKi-P-MEKi-PP
type: Species

metaid_0000203
constant: true
units: metaid_0000324
value: 960.0
type: Parameter

863035
stoichiometry: 1.0
species: metaid_0000091
type: SpeciesReference

metaid_0000170
constant: true
units: metaid_0000326
value: 7.0E-5
type: Parameter

862297
stoichiometry: 1.0
species: metaid_0000053
type: SpeciesReference

861801
stoichiometry: 1.0
species: metaid_0000035
type: SpeciesReference

861340
stoichiometry: 1.0
species: metaid_0000029
type: SpeciesReference

863529
stoichiometry: 1.0
species: metaid_0000070
type: SpeciesReference

metaid_0000014
is version of: GO:0030119
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: metaid_0000005
name: Proti
type: Species

metaid_0000190
constant: true
units: metaid_0000324
value: 60.0
type: Parameter

metaid_0000086
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: metaid_0000005
name: ERKi-P
type: Species

metaid_0000024
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: metaid_0000005
name: EGF-EGFRi*^2-GAP-Grb2-Sos
type: Species

862309
stoichiometry: 1.0
species: metaid_0000054
type: SpeciesReference

862152
stoichiometry: 1.0
species: metaid_0000049
type: SpeciesReference

metaid_0000062
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: metaid_0000005
name: ERK-P
type: Species

863505
stoichiometry: 1.0
species: metaid_0000027
type: SpeciesReference

865688
stoichiometry: 1.0
species: metaid_0000017
type: SpeciesReference

863349
stoichiometry: 1.0
species: metaid_0000026
type: SpeciesReference

862891
stoichiometry: 1.0
species: metaid_0000062
type: SpeciesReference

metaid_0000124
constant: true
units: metaid_0000324
value: 0.228
type: Parameter

860915
stoichiometry: 1.0
species: metaid_0000027
type: SpeciesReference

864399
stoichiometry: 1.0
species: metaid_0000082
type: SpeciesReference

862067
stoichiometry: 1.0
species: metaid_0000044
type: SpeciesReference

metaid_0000023
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: metaid_0000005
name: EGF-EGFRi*^2-GAP-Grb2
type: Species

865964
stoichiometry: 1.0
species: metaid_0000099
type: SpeciesReference

864108
stoichiometry: 1.0
species: metaid_0000071
type: SpeciesReference

865038
stoichiometry: 1.0
species: metaid_0000037
type: SpeciesReference

864205
stoichiometry: 1.0
species: metaid_0000049
type: SpeciesReference

863843
stoichiometry: 1.0
species: metaid_0000073
type: SpeciesReference

metaid_0000063
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: metaid_0000005
name: ERK-P-MEK-PP
type: Species

863903
stoichiometry: 1.0
species: metaid_0000022
type: SpeciesReference

864482
stoichiometry: 1.0
species: metaid_0000080
type: SpeciesReference

metaid_0000125
constant: true
units: metaid_0000324
value: 6.0
type: Parameter

860262
exponent: -1.0
scale: 0
multipler: 1.0
kind: ITEM
type: SBMLUnit

862551
stoichiometry: 1.0
species: metaid_0000054
type: SpeciesReference

metaid_0000022
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: metaid_0000005
name: EGF-EGFRi*^2-GAP
type: Species

862261
stoichiometry: 1.0
species: metaid_0000050
type: SpeciesReference

862200
stoichiometry: 1.0
species: metaid_0000051
type: SpeciesReference

metaid_0000060
is described by: http://identifiers.org/omim/176948
initial amount: 2.1E7
is version of: P28482
boundary condition: false
has only substance units: true
name: ERK
constant: false
initial concentration: NaN
in compartment: metaid_0000005
type: Species

862927
stoichiometry: 1.0
species: metaid_0000065
type: SpeciesReference

864834
stoichiometry: 1.0
species: metaid_0000089
type: SpeciesReference

863445
stoichiometry: 1.0
species: metaid_0000068
type: SpeciesReference

861582
stoichiometry: 1.0
species: metaid_0000040
type: SpeciesReference

864724
stoichiometry: 1.0
species: metaid_0000086
type: SpeciesReference

metaid_0000021
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: metaid_0000005
name: EGFi
type: Species

861074
stoichiometry: 1.0
species: metaid_0000033
type: SpeciesReference

860334
stoichiometry: 1.0
species: metaid_0000008
type: SpeciesReference

861679
stoichiometry: 1.0
species: metaid_0000040
type: SpeciesReference

863071
stoichiometry: 1.0
species: metaid_0000018
type: SpeciesReference

861910
stoichiometry: 1.0
species: metaid_0000038
type: SpeciesReference

metaid_0000061
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: metaid_0000005
name: ERK-MEK-PP
type: Species

metaid_0000123
constant: true
units: metaid_0000326
value: 0.003
type: Parameter

metaid_0000020
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: metaid_0000004
name: EGF-EGFR*^2-GAP
type: Species

864639
stoichiometry: 1.0
species: metaid_0000085
type: SpeciesReference

metaid_0000148
constant: true
units: metaid_0000326
value: 0.001
type: Parameter

861388
stoichiometry: 1.0
species: metaid_0000031
type: SpeciesReference

864882
stoichiometry: 1.0
species: metaid_0000065
type: SpeciesReference

861498
stoichiometry: 1.0
species: metaid_0000046
type: SpeciesReference

862176
stoichiometry: 1.0
species: metaid_0000051
type: SpeciesReference

metaid_0000323
unit: 860201
name: pl
type: SBMLUnitsDef

metaid_0000128
constant: true
units: metaid_0000324
value: 0.6
type: Parameter

861208
stoichiometry: 1.0
species: metaid_0000036
type: SpeciesReference

metaid_0000149
constant: true
units: metaid_0000324
value: 3.6
type: Parameter

864229
stoichiometry: 1.0
species: metaid_0000052
type: SpeciesReference

865988
stoichiometry: 1.0
species: metaid_0000099
type: SpeciesReference

865568
stoichiometry: 1.0
species: metaid_0000096
type: SpeciesReference

863999
stoichiometry: 1.0
species: metaid_0000022
type: SpeciesReference

863385
stoichiometry: 1.0
species: metaid_0000024
type: SpeciesReference

861061
stoichiometry: 1.0
species: metaid_0000032
type: SpeciesReference

metaid_0000129
constant: true
units: metaid_0000326
value: 1.038E-5
type: Parameter

metaid_0000322
unit: 860189
name: min
type: SBMLUnitsDef

metaid_0000146
constant: true
units: metaid_0000324
value: 600000.0
type: Parameter

864289
stoichiometry: 1.0
species: metaid_0000080
type: SpeciesReference

863553
stoichiometry: 1.0
species: metaid_0000029
type: SpeciesReference

861655
stoichiometry: 1.0
species: metaid_0000031
type: SpeciesReference

860310
stoichiometry: 1.0
species: metaid_0000006
type: SpeciesReference

865772
stoichiometry: 1.0
species: metaid_0000041
type: SpeciesReference

862903
stoichiometry: 1.0
species: metaid_0000065
type: SpeciesReference

863180
stoichiometry: 1.0
species: metaid_0000029
type: SpeciesReference

862224
stoichiometry: 1.0
species: metaid_0000049
type: SpeciesReference

metaid_0000321
unit: 860177
name: items
type: SBMLUnitsDef

863469
stoichiometry: 1.0
species: metaid_0000068
type: SpeciesReference

metaid_0000126
constant: true
units: metaid_0000326
value: 0.001
type: Parameter

metaid_0000147
constant: true
units: metaid_0000324
value: 16.5
type: Parameter

864374
stoichiometry: 1.0
species: metaid_0000081
type: SpeciesReference

863095
stoichiometry: 1.0
species: metaid_0000013
type: SpeciesReference

861934
stoichiometry: 1.0
species: metaid_0000045
type: SpeciesReference

metaid_0000320
kinetic law: 865266
product: 865254
reactant: 865242
fast: false
reversible: true
name: v108
type: Reaction

metaid_0000127
constant: true
units: metaid_0000324
value: 60.0
type: Parameter

864337
stoichiometry: 1.0
species: metaid_0000080
type: SpeciesReference

metaid_0000042
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: metaid_0000005
name: EGF-EGFR*^2-GAP-Shc*-Grb2-Sos-Ras-GTP
type: Species

863277
stoichiometry: 1.0
species: metaid_0000025
type: SpeciesReference

metaid_0000327
unit: 860298
unit: 860286
unit: 860274
name: plperitempermin
type: SBMLUnitsDef

metaid_0000307
kinetic law: 864700
product: 864688
product: 864675
reactant: 864663
fast: false
reversible: true
name: v95
type: Reaction

metaid_0000257
kinetic law: 862333
product: 862321
product: 862309
reactant: 862297
fast: false
reversible: true
name: v45
type: Reaction

865050
stoichiometry: 1.0
species: metaid_0000068
type: SpeciesReference

metaid_0000326
unit: 860262
unit: 860250
name: peritempermin
type: SBMLUnitsDef

metaid_0000043
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: metaid_0000005
name: Shc*-Grb2-Sos
type: Species

862987
stoichiometry: 1.0
species: metaid_0000060
type: SpeciesReference

metaid_0000306
kinetic law: 864651
product: 864639
reactant: 864627
reactant: 864615
fast: false
reversible: true
name: v94
type: Reaction

865640
stoichiometry: 1.0
species: metaid_0000040
type: SpeciesReference

metaid_0000258
kinetic law: 862381
product: 862369
reactant: 862357
reactant: 862345
fast: false
reversible: true
name: v46
type: Reaction

metaid_0000044
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: metaid_0000005
name: Shc*-Grb2
type: Species

863143
stoichiometry: 1.0
species: metaid_0000027
type: SpeciesReference

metaid_0000040
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: metaid_0000005
name: EGF-EGFR*^2-GAP-Shc*-Grb2-Sos
type: Species

metaid_0000325
unit: 860237
unit: 860225
name: itemspermin
type: SBMLUnitsDef

861958
stoichiometry: 1.0
species: metaid_0000027
type: SpeciesReference

metaid_0000069
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: metaid_0000005
name: EGF-EGFRi*^2-GAP-Shc*
type: Species

metaid_0000344
kinetic law: 866024
product: 866012
product: 866000
reactant: 865988
fast: false
reversible: true
name: v125
type: Reaction

865832
stoichiometry: 1.0
species: metaid_0000098
type: SpeciesReference

862394
stoichiometry: 1.0
species: metaid_0000055
type: SpeciesReference

metaid_0000305
kinetic law: 864603
product: 864591
product: 864579
reactant: 864567
fast: false
reversible: true
name: v93
type: Reaction

861546
stoichiometry: 1.0
species: metaid_0000048
type: SpeciesReference

862249
stoichiometry: 1.0
species: metaid_0000052
type: SpeciesReference

metaid_0000255
kinetic law: 862237
product: 862224
product: 862212
reactant: 862200
fast: false
reversible: true
name: v43
type: Reaction

860394
stoichiometry: 1.0
species: metaid_0000009
type: SpeciesReference

864675
stoichiometry: 1.0
species: metaid_0000086
type: SpeciesReference

861631
stoichiometry: 1.0
species: metaid_0000042
type: SpeciesReference

metaid_0000041
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: metaid_0000005
name: EGF-EGFR*^2-GAP-Shc*-Grb2-Sos-Ras-GDP
type: Species

metaid_0000324
unit: 860213
name: permin
type: SBMLUnitsDef

860539
stoichiometry: 1.0
species: metaid_0000011
type: SpeciesReference

861256
stoichiometry: 1.0
species: metaid_0000037
type: SpeciesReference

metaid_0000256
kinetic law: 862285
product: 862273
reactant: 862261
reactant: 862249
fast: false
reversible: true
name: v44
type: Reaction

864084
stoichiometry: 1.0
species: metaid_0000035
type: SpeciesReference

metaid_0000304
kinetic law: 864555
product: 864543
reactant: 864531
reactant: 864519
fast: false
reversible: true
name: v92
type: Reaction

863577
stoichiometry: 1.0
species: metaid_0000071
type: SpeciesReference

metaid_0000342
kinetic law: 865928
product: 865916
reactant: 865904
fast: false
reversible: true
name: v123
type: Reaction

860286
exponent: -1.0
scale: 0
multipler: 1.0
kind: ITEM
type: SBMLUnit

metaid_0000067
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: metaid_0000005
name: ERK-P-P'ase3
type: Species

862443
stoichiometry: 1.0
species: metaid_0000056
type: SpeciesReference

863951
stoichiometry: 1.0
species: metaid_0000022
type: SpeciesReference

865014
stoichiometry: 1.0
species: metaid_0000022
type: SpeciesReference

metaid_0000303
kinetic law: 864507
product: 864495
product: 864482
reactant: 864470
fast: false
reversible: true
name: v91
type: Reaction

metaid_0000047
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: metaid_0000005
name: Raf-Ras-GTP
type: Species

860189
exponent: 1.0
scale: 0
multipler: 60.0
kind: SECOND
type: SBMLUnit

865940
stoichiometry: 1.0
species: metaid_0000042
type: SpeciesReference

864906
stoichiometry: 1.0
species: metaid_0000065
type: SpeciesReference

863253
stoichiometry: 1.0
species: metaid_0000025
type: SpeciesReference

863867
stoichiometry: 1.0
species: metaid_0000031
type: SpeciesReference

863107
stoichiometry: 1.0
species: metaid_0000092
type: SpeciesReference

862757
stoichiometry: 1.0
species: metaid_0000063
type: SpeciesReference

metaid_0000343
kinetic law: 865976
product: 865964
reactant: 865952
reactant: 865940
fast: false
reversible: true
name: v124
type: Reaction

metaid_0000068
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: metaid_0000005
name: EGF-EGFRi*^2-GAP-Shc
type: Species

metaid_0000302
kinetic law: 864458
product: 864446
reactant: 864435
reactant: 864423
fast: false
reversible: true
name: v90
type: Reaction

861111
stoichiometry: 1.0
species: metaid_0000030
type: SpeciesReference

864966
stoichiometry: 1.0
species: metaid_0000060
type: SpeciesReference

864591
stoichiometry: 1.0
species: metaid_0000058
type: SpeciesReference

metaid_0000048
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: metaid_0000005
name: Ras-GTP*
type: Species

metaid_0000329
kinetic law: 865363
product: 865351
product: 865339
reactant: 865327
fast: false
reversible: true
name: v110
type: Reaction

865856
stoichiometry: 1.0
species: metaid_0000098
type: SpeciesReference

865290
stoichiometry: 1.0
species: metaid_0000017
type: SpeciesReference

861292
stoichiometry: 1.0
species: metaid_0000027
type: SpeciesReference

864615
stoichiometry: 1.0
species: metaid_0000060
type: SpeciesReference

860370
stoichiometry: 1.0
species: metaid_0000009
type: SpeciesReference

metaid_0000279
kinetic law: 863361
product: 863349
reactant: 863337
reactant: 863325
fast: false
reversible: true
name: v67
type: Reaction

862357
stoichiometry: 1.0
species: metaid_0000050
type: SpeciesReference

metaid_0000064
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: metaid_0000005
name: ERK-PP
type: Species

metaid_0000259
kinetic law: 862431
product: 862419
product: 862406
reactant: 862394
fast: false
reversible: true
name: v47
type: Reaction

metaid_0000045
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: metaid_0000005
name: Shc*
type: Species

metaid_0000301
kinetic law: 864411
product: 864399
product: 864387
reactant: 864374
fast: false
reversible: true
name: v89
type: Reaction

860443
stoichiometry: 1.0
species: metaid_0000017
type: SpeciesReference

865436
stoichiometry: 1.0
species: metaid_0000095
type: SpeciesReference

metaid_0000328
kinetic law: 865314
product: 865302
reactant: 865290
reactant: 865278
fast: false
reversible: true
name: v109
type: Reaction

metaid_0000341
kinetic law: 865892
product: 865880
product: 865868
reactant: 865856
fast: false
reversible: true
name: v122
type: Reaction

861316
stoichiometry: 1.0
species: metaid_0000039
type: SpeciesReference

863421
stoichiometry: 1.0
species: metaid_0000036
type: SpeciesReference

864241
stoichiometry: 1.0
species: metaid_0000077
type: SpeciesReference

metaid_0000066
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: metaid_0000005
name: ERK-PP-P'ase3
type: Species

metaid_0000065
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 1.0E7
in compartment: metaid_0000005
name: Phosphotase3
type: Species

862707
stoichiometry: 1.0
species: metaid_0000062
type: SpeciesReference

metaid_0000300
kinetic law: 864361
product: 864349
reactant: 864337
reactant: 864325
fast: false
reversible: true
name: v88
type: Reaction

metaid_0000046
is version of: P04049
name: Raf
has only substance units: true
initial amount: 40000.0
boundary condition: false
type: Species
is described by: http://identifiers.org/omim/164760
constant: false
initial concentration: NaN
in compartment: metaid_0000005

862647
stoichiometry: 1.0
species: metaid_0000056
type: SpeciesReference

metaid_0000340
kinetic law: 865844
product: 865832
reactant: 865820
reactant: 865808
fast: false
reversible: true
name: v121
type: Reaction

orgname: MIT

ORG:
  orgname: EMBL-EBI
n:
  given: Nicolas
  family: Le Novère

W3 CDTF: Tue May 17 17:40:56 BST 2011

ORG:
  orgname: Mt. Sinai Hospital/ Univ. of Toronto
n:
  given: Ken
  family: Lau

n:
  given: Birgit
  family: Schoeberl