192122
is version of: GO:0051019
fast: false
reversible: false
name: binding of MAPK-P and MAPK phosphatase
type: Reaction

191862
type: Reaction
is homolog to: REACT 614
fast: false
is version of: GO:0006468
is version of: GO:0004709
reversible: false
name: phosphorylation of MEK
is version of: http://identifiers.org/ec-code/2.7.11.25

http://identifiers.org/biomodels.db/BIOMD0000000011#_4c8cdcc8_81f2_4769_9ff5_4dfe9018b263
stoichiometry: 1.0
species: 191301
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000011#a7c5b03c_c796_4385_b818_15899e4bfd19
stoichiometry: 1.0
species: 191521
type: SpeciesReference

972037
value: 0.4
type: LocalParameter

http://identifiers.org/biomodels.db/BIOMD0000000011#_1df91187_f25b_4db1_867f_16980e077efd
stoichiometry: 1.0
species: 191501
type: SpeciesReference

191962
is version of: GO:0043241
fast: false
reversible: false
name: dissociation of MEK-P_RAF-P
type: Reaction

972043
value: 0.5
type: LocalParameter

http://identifiers.org/biomodels.db/BIOMD0000000011#eb27fc68_9837_4e12_996a_cb26ab997ca8
stoichiometry: 1.0
species: 191501
type: SpeciesReference

192102
is homolog to: REACT 2247
is version of: GO:0006468
is version of: GO:0004708
is homolog to: REACT 136
name: phosphorylation of MAPK
reversible: false
type: Reaction
fast: false
is version of: http://identifiers.org/ec-code/2.7.12.2

972085
value: 0.6
type: LocalParameter

http://identifiers.org/biomodels.db/BIOMD0000000011#_1f6acff8_3a09_45a5_9131_e6b3b1d7b382
stoichiometry: 1.0
species: 191561
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000011#_4d7a4eed_b074_47ab_9e17_8c7a8e9e1d07
stoichiometry: 1.0
species: 191641
type: SpeciesReference

972057
value: 0.1
type: LocalParameter

http://identifiers.org/biomodels.db/BIOMD0000000011#_9163254e_c480_4c29_b5f7_7493000ecfe7
stoichiometry: 1.0
species: 191541
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000011#_2aeba255_b065_44c3_8ed2_e74c59ee90ce
stoichiometry: 1.0
species: 191401
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000011#c23c39e7_8eee_45d0_88e1_5c27e8c1ab19
stoichiometry: 1.0
species: 191501
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000011#_215075a5_1d22_4566_8346_3ed1c56d81d3
stoichiometry: 1.0
species: 191621
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000011#e3911e41_7dec_41e1_8bfc_1222c2d82577
stoichiometry: 1.0
species: 191661
type: SpeciesReference

191983
reversible: false
name: phosphorylation of MEK-P
is homolog to: REACT 614
is version of: GO:0000186
is version of: http://identifiers.org/ec-code/2.7.11.25
is version of: GO:0004709
fast: false
is version of: GO:0006468
type: Reaction

http://identifiers.org/biomodels.db/BIOMD0000000011#_7196460d_30b3_446b_aa7f_ca4c22280039
stoichiometry: 1.0
species: 191621
type: SpeciesReference

972075
value: 0.1
type: LocalParameter

972065
value: 10.0
type: LocalParameter

http://identifiers.org/biomodels.db/BIOMD0000000011#_56b2b9ff_7222_44bf_8a67_d508a056d8b4
stoichiometry: 1.0
species: 191581
type: SpeciesReference

192182
name: binding of MAPK-P and MEK-PP
fast: false
is version of: GO:0051019
type: Reaction
is homolog to: REACT 495
reversible: false
is version of: GO:0031434
is homolog to: REACT 1780

metaid_0000030
name: micromole
type: SBMLUnitsDef

191763
is version of: GO:0031435
fast: false
reversible: false
name: binding of RAF-P and RAF phosphatase
type: Reaction

972035
value: 1.0
type: LocalParameter

972063
value: 0.1
type: LocalParameter

http://identifiers.org/biomodels.db/BIOMD0000000011#_15746a2a_a0d8_470f_aa80_e7a19095bfc8
stoichiometry: 1.0
species: 191261
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000011#_3fb03245_76c0_4f89_9e10_4460dd937309
stoichiometry: 1.0
species: 191441
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000011#fa9eb5a3_ff62_4991_adf4_7756c3571836
stoichiometry: 1.0
species: 191341
type: SpeciesReference

BIOMD0000000011
type: SBMLModel
reaction: 192162
reaction: 192083
is derived from: http://identifiers.org/pubmed/6501300
species: 191361
reaction: 191902
species: 191421
species: 191401
species: 191561
species: 191541
reaction: 192063
species: 191621
reaction: 192122
species: 191341
reaction: 192042
reaction: 192223
volume units: volume
is homolog to: REACT 634
species: 191601
reaction: 191983
species: 191501
area units: area
reaction: 192262
is: MODEL6615234250
length unit: length
reaction: 191943
species: 191301
reaction: 192142
modified:
  W3 CDTF: Mon Jun 03 14:36:09 BST 2013
reaction: 191763
species: 191441
reaction: 192102
curated: true
creator:
  ORG:
    orgname: NASA Jet Propulsion Laboratory
  n:
    given: Bruce
    family: Shapiro
reaction: 191823
reaction: 192182
time units: metaid_0000018
reaction: 192022
occurs in: http://identifiers.org/taxonomy/8355
reaction: 191803
species: 191641
reaction: 191702
reaction: 191923
reaction: 191883
is described by: http://identifiers.org/pubmed/10823939
is derived from: http://identifiers.org/pubmed/6947258
species: 191321
reaction: 191743
notes: MAPK cascade in solution (no scaffold) Description This model describes a basic 3- stage Mitogen Activated Protein Kinase (MAPK) cascade in solution. This cascade is typically expressed as RAF= =>MEK==>MAPK (alternative forms are K3==>K2==> K1 and KKK==>KK==>K) . The input signal is RAFK (RAF Kinase) and the output signal is MAPKpp ( doubly phosphorylated form of MAPK) . RAFK phosphorylates RAF once to RAFp. RAFp, the phosphorylated form of RAF induces two phoshporylations of MEK, to MEKp and MEKpp. MEKpp, the doubly phosphorylated form of MEK, induces two phosphorylations of MAPK to MAPKp and MAPKpp. Rate constant Reaction a10 = 5. MAPKPH + MAPKpp -> MAPKppMAPKPH a1 = 1. RAF + RAFK -> RAFRAFK a2 = 0.5 RAFp + RAFPH -> RAFpRAFPH a3 = 3.3 MEK + RAFp -> MEKRAFp a4 = 10. MEKp + MEKPH -> MEKpMEKPH a5 = 3.3 MEKp + RAFp -> MEKpRAFp a6 = 10. MEKPH + MEKpp -> MEKppMEKPH a7 = 20. MAPK + MEKpp -> MAPKMEKpp a8 = 5. MAPKp + MAPKPH -> MAPKpMAPKPH a9 = 20. MAPKp + MEKpp -> MAPKpMEKpp d10 = 0.4 MAPKppMAPKPH -> MAPKPH + MAPKpp d1 = 0.4 RAFRAFK -> RAF + RAFK d2 = 0.5 RAFpRAFPH -> RAFp + RAFPH d3 = 0.42 MEKRAFp -> MEK + RAFp d4 = 0.8 MEKpMEKPH -> MEKp + MEKPH d5 = 0.4 MEKpRAFp -> MEKp + RAFp d6 = 0.8 MEKppMEKPH -> MEKPH + MEKpp d7 = 0.6 MAPKMEKpp -> MAPK + MEKpp d8 = 0.4 MAPKpMAPKPH -> MAPKp + MAPKPH d9 = 0.6 MAPKpMEKpp -> MAPKp + MEKpp k10 = 0.1 MAPKppMAPKPH -> MAPKp + MAPKPH k1 = 0.1 RAFRAFK -> RAFK + RAFp k2 = 0.1 RAFpRAFPH -> RAF + RAFPH k3 = 0.1 MEKRAFp -> MEKp + RAFp k4 = 0.1 MEKpMEKPH -> MEK + MEKPH k5 = 0.1 MEKpRAFp -> MEKpp + RAFp k6 = 0.1 MEKppMEKPH -> MEKp + MEKPH k7 = 0.1 MAPKMEKpp -> MAPKp + MEKpp k8 = 0.1 MAPKpMAPKPH -> MAPK + MAPKPH k9 = 0.1 MAPKpMEKpp -> MAPKpp + MEKpp Variable IC ODE MAPK 0.3 MAPK'[t] == d7*MAPKMEKpp[t] + k8*MAPKpMAPKPH[t] - a7*MAPK[t]*MEKpp[t] MAPKMEKpp 0 MAPKMEKpp'[t] == -(d7*MAPKMEKpp[t]) - k7*MAPKMEKpp[t] + a7*MAPK[t]*MEKpp[t] MAPKp 0 MAPKp'[t] == k7*MAPKMEKpp[t] - a8*MAPKp[t]*MAPKPH[t] + d8*MAPKpMAPKPH[t] + d9*MAPKpMEKpp[t] + k10* MAPKppMAPKPH[t]…
species: 191521
is version of: GO:0000165
reaction: 191843
reaction: 192203
is derived from: BIOMD0000000009
reaction: 192283
species: 191481
reaction: 191783
reaction: 192002
species: 191381
reaction: 191722
name: Levchenko2000_MAPK_noScaffold
species: 191281
compartment: 191248
substance units: metaid_0000030
units def: metaid_0000030
reaction: 192243
species: 191461
reaction: 191962
species: 191681
species: 191661
species: 191581
created:
  W3 CDTF: Tue Feb 15 00:12:30 GMT 2005
reaction: 191862
species: 191261

http://identifiers.org/biomodels.db/BIOMD0000000011#_7710a8e8_7870_4d01_9286_78b3491916ba
stoichiometry: 1.0
species: 191441
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000011#cbc099ed_dfbc_42d5_a5f2_1df1f065444c
stoichiometry: 1.0
species: 191501
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000011#_65c456b9_8cc3_4835_b18a_37a023acf44e
stoichiometry: 1.0
species: 191481
type: SpeciesReference

972045
value: 0.1
type: LocalParameter

972083
value: 20.0
type: LocalParameter

http://identifiers.org/biomodels.db/BIOMD0000000011#_66b9da2f_b3bc_4543_b862_d168fffc7e9e
stoichiometry: 1.0
species: 191641
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000011#_899522a9_ca1e_4d99_b7f0_bcc1621cd6c4
stoichiometry: 1.0
species: 191341
type: SpeciesReference

972055
value: 0.8
type: LocalParameter

http://identifiers.org/biomodels.db/BIOMD0000000011#bbcd650d_2fcf_4688_86e5_4543f6f100c1
stoichiometry: 1.0
species: 191661
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000011#_8577ea4e_2644_4023_b39b_6e6c4aeded3e
stoichiometry: 1.0
species: 191501
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000011#_8dac4f2b_6c16_4de1_9c42_e2e3cecd7443
stoichiometry: 1.0
species: 191681
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000011#_11cd2721_3bd7_4a5e_bf30_f6aeb90a901f
stoichiometry: 1.0
species: 191561
type: SpeciesReference

192142
is version of: GO:0043241
fast: false
reversible: false
name: dissociation of MAPK-P_MAPKPase
type: Reaction

972077
value: 5.0
type: LocalParameter

192162
is version of: http://identifiers.org/ec-code/3.1.3.16
name: dephosphorylation of MAPK-P
reversible: false
is version of: GO:0006470
fast: false
type: Reaction

http://identifiers.org/biomodels.db/BIOMD0000000011#_65bdcf07_bd09_4843_bb9c_190d451a0657
stoichiometry: 1.0
species: 191301
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000011#_7e80b205_5e24_409c_9070_b01d77cedb6f
stoichiometry: 1.0
species: 191621
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000011#_470174bf_b814_48e1_8dca_2e8941962768
stoichiometry: 1.0
species: 191581
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000011#a32b7dee_83ff_43b5_bb3b_a2d3c0244d59
stoichiometry: 1.0
species: 191681
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000011#aaf1fb12_b585_441a_be07_dfef4c3b5e65
stoichiometry: 1.0
species: 191461
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000011#dd2b0185_62fb_43b6_8416_cb1499764388
stoichiometry: 1.0
species: 191421
type: SpeciesReference

192002
is version of: GO:0031434
fast: false
reversible: false
name: binding of MEK-PP and MEK phosphatase
type: Reaction

http://identifiers.org/biomodels.db/BIOMD0000000011#_6d47de5a_dc61_43f0_9711_57d53e5082c4
stoichiometry: 1.0
species: 191301
type: SpeciesReference

972071
value: 20.0
type: LocalParameter

191261
is version of: P26696
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.4
in compartment: 191248
name: MAPK
type: Species

972061
value: 0.4
type: LocalParameter

http://identifiers.org/biomodels.db/BIOMD0000000011#_80b6c489_0291_414f_9ce7_cd09dfd70a76
stoichiometry: 1.0
species: 191421
type: SpeciesReference

972047
value: 3.3
type: LocalParameter

http://identifiers.org/biomodels.db/BIOMD0000000011#_8e731583_9eb1_40e8_bf1d_dcca981eccdd
stoichiometry: 1.0
species: 191461
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000011#_018f6cfe_2b8a_4b92_b60f_706de500162e
stoichiometry: 1.0
species: 191681
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000011#_9a07be9f_b2dd_4b5c_89ef_f0dccf7c4aeb
stoichiometry: 1.0
species: 191281
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000011#_897eefeb_6f1f_4083_a689_50771f166cb3
stoichiometry: 1.0
species: 191361
type: SpeciesReference

191681
initial amount: 0.0
has only substance units: true
constant: false
initial concentration: NaN
has part: P09560
in compartment: 191248
has part: IPR003577
boundary condition: false
type: Species
name: RAF_RAFK

972089
value: 5.0
type: LocalParameter

http://identifiers.org/biomodels.db/BIOMD0000000011#_8ea6a3a5_3dcf_4273_9c8c_822be63b41dc
stoichiometry: 1.0
species: 191501
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000011#_591f4916_a28a_4338_92c1_9e403cb76e9d
stoichiometry: 1.0
species: 191521
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000011#f4be023a_0c16_4d16_aaeb_d2fc0545a1ad
stoichiometry: 1.0
species: 191321
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000011#d14a23dd_4907_4591_9575_7cae418f1782
stoichiometry: 1.0
species: 191461
type: SpeciesReference

192042
is version of: GO:0006470
is version of: GO:0051389
reversible: false
fast: false
type: Reaction
name: dephosphorylation of MEK-PP
is version of: http://identifiers.org/ec-code/3.1.3.16

http://identifiers.org/biomodels.db/BIOMD0000000011#_1a541711_e8d4_4ae4_833f_599bb0dd8f16
stoichiometry: 1.0
species: 191381
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000011#eb99a1a9_95c4_46c8_b210_2246a24e9ded
stoichiometry: 1.0
species: 191461
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000011#af2512de_407f_4da4_9ed1_dd84745c0937
stoichiometry: 1.0
species: 191321
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000011#e01c2e92_69dc_46e1_a3aa_88657b0e3ccb
stoichiometry: 1.0
species: 191401
type: SpeciesReference

191341
boundary condition: false
has part: P26696
has part: Q90W58
initial amount: 0.0
constant: false
initial concentration: NaN
in compartment: 191248
has only substance units: true
type: Species
name: MAPK-P_MAPKPase

191621
is version of: P09560
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 191248
name: RAF-P
type: Species

972073
value: 0.6
type: LocalParameter

http://identifiers.org/biomodels.db/BIOMD0000000011#_0f809334_a7dd_4376_af7a_1ca8fd21b03c
stoichiometry: 1.0
species: 191381
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000011#_0e9b0421_2a6a_429e_ad80_3469882ac6aa
stoichiometry: 1.0
species: 191301
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000011#be93d9bc_9f9b_4e7c_b009_44abf972e709
stoichiometry: 1.0
species: 191321
type: SpeciesReference

191321
is: Q90W58
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.3
in compartment: 191248
name: MAPK phosphatase
type: Species

191248
is: GO:0005737
constant: true
size: 1.0
spatial dimensions: 3.0
type: Compartment

191301
is version of: P26696
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 191248
name: MAPK-P
type: Species

972059
value: 3.3
type: LocalParameter

http://identifiers.org/biomodels.db/BIOMD0000000011#fd39b9fa_6c90_4a82_a283_0676d9e8a39f
stoichiometry: 1.0
species: 191301
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000011#e567c51e_5490_4cf5_bcc6_53558ddf12cd
stoichiometry: 1.0
species: 191501
type: SpeciesReference

191361
has part: Q05116
initial concentration: NaN
has part: P26696
type: Species
in compartment: 191248
initial amount: 0.0
has only substance units: true
constant: false
boundary condition: false
name: MAPK-P_MEK-PP

191601
is version of: IPR003577
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.2
in compartment: 191248
name: RAFK
type: Species

972049
value: 0.42
type: LocalParameter

191923
type: Reaction
fast: false
reversible: false
is version of: http://identifiers.org/ec-code/3.1.3.16
is version of: GO:0006470
name: dephosphorylation of MEK-P

http://identifiers.org/biomodels.db/BIOMD0000000011#_35792aaa_8124_4fca_8915_c6eb4f8aa31c
stoichiometry: 1.0
species: 191261
type: SpeciesReference

191661
has part: P09560
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 191248
name: RAF-P_RAFPase
type: Species

http://identifiers.org/biomodels.db/BIOMD0000000011#_066c4c9c_b27b_4ff4_b3c8_0c476ddbcfa6
stoichiometry: 1.0
species: 191481
type: SpeciesReference

972087
value: 0.1
type: LocalParameter

191641
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.3
in compartment: 191248
name: RAF phosphatase
type: Species

191722
is version of: GO:0043241
fast: false
reversible: false
name: dissociation of RAF_RAFK
type: Reaction

http://identifiers.org/biomodels.db/BIOMD0000000011#_3fa5c6d3_438b_4e36_90e1_42175153d4cf
stoichiometry: 1.0
species: 191321
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000011#_3ab8fbb1_cb9d_4874_8609_2e8dc580499f
stoichiometry: 1.0
species: 191441
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000011#_13d29e4d_cdb0_4759_b52a_b3c3f06a5b6d
stoichiometry: 1.0
species: 191341
type: SpeciesReference

191823
is version of: GO:0031435
is version of: GO:0031434
reversible: false
name: binding of MEK and RAF-P
type: Reaction
is homolog to: REACT 143
fast: false

http://identifiers.org/biomodels.db/BIOMD0000000011#_4cf5b8f3_6552_408b_a407_a76db1c80c01
stoichiometry: 1.0
species: 191621
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000011#_5fd82246_303a_45bd_82d6_2ae62c76aeb6
stoichiometry: 1.0
species: 191561
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000011#b4a66d0a_3ba8_4c52_9271_196877d1880f
stoichiometry: 1.0
species: 191441
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000011#_2fe6bebc_9e69_49ee_a025_3f3244778f2a
stoichiometry: 1.0
species: 191321
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000011#_080d440e_71dc_4be8_ba3f_878e51736698
stoichiometry: 1.0
species: 191641
type: SpeciesReference

191783
is version of: GO:0043241
fast: false
reversible: false
name: dissociation of RAF-P_RAFPase
type: Reaction

191702
fast: false
is homolog to: REACT 996
type: Reaction
name: binding of RAF and RAFK
reversible: false
is version of: GO:0031435

http://identifiers.org/biomodels.db/BIOMD0000000011#b16f3aae_396c_4494_925f_78868575a286
stoichiometry: 1.0
species: 191601
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000011#_63b9590a_323d_4fb0_bc76_f34539cea620
stoichiometry: 1.0
species: 191441
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000011#_9a1d162c_c4f6_4ad5_9c6e_ae8159532834
stoichiometry: 1.0
species: 191601
type: SpeciesReference

192063
fast: false
is homolog to: REACT 1780
is homolog to: REACT 495
is: GO:0031434
reversible: false
name: binding of MAPK and MEK-PP
type: Reaction
is: GO:0051019

192083
is version of: GO:0043241
fast: false
reversible: false
name: dissociation of MAPK_MEK-PP
type: Reaction

http://identifiers.org/biomodels.db/BIOMD0000000011#_7b5e6bc8_ee75_4316_b17e_04ebcf1532cf
stoichiometry: 1.0
species: 191441
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000011#f97c27c3_a98a_40f0_a447_9cc43d1a1e3d
stoichiometry: 1.0
species: 191481
type: SpeciesReference

192283
type: Reaction
is version of: http://identifiers.org/ec-code/3.1.3.16
is version of: GO:0000188
is version of: GO:0006470
name: dephosphorylation of MAPK-PP
fast: false
reversible: false

191743
is version of: GO:0000185
fast: false
reversible: false
is version of: GO:0006468
type: Reaction
is version of: GO:0008349
is version of: http://identifiers.org/ec-code/2.7.11.1
name: phosphorylation of RAF

http://identifiers.org/biomodels.db/BIOMD0000000011#d5cf7422_8558_4f0e_86b6_964dfd40721c
stoichiometry: 1.0
species: 191601
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000011#_045cae2d_22c3_49a3_a090_1cdcf4ad6c68
stoichiometry: 1.0
species: 191621
type: SpeciesReference

192243
is version of: GO:0051019
fast: false
reversible: false
name: binding of MAPK-PP and MAPK phosphatase
type: Reaction

192203
is version of: GO:0043241
fast: false
reversible: false
name: dissociation of MAPK-P_MEK-PP
type: Reaction

191381
is version of: P26696
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 191248
name: MAPK-PP
type: Species

http://identifiers.org/biomodels.db/BIOMD0000000011#_649b4de5_4777_44ed_be7c_07878128d747
stoichiometry: 1.0
species: 191621
type: SpeciesReference

192223
type: Reaction
is homolog to: REACT 2247
is version of: GO:0006468
reversible: false
is version of: http://identifiers.org/ec-code/2.7.12.2
is version of: GO:0004708
is homolog to: REACT 136
is version of: GO:0000187
fast: false
name: phosphorylation of MAPK-P

http://identifiers.org/biomodels.db/BIOMD0000000011#_01c0fbf6_3513_4ab0_b5bc_534e98e4f95d
stoichiometry: 1.0
species: 191421
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000011#_76a756c1_9b69_4295_ad1d_54d2ccf40f4f
stoichiometry: 1.0
species: 191261
type: SpeciesReference

191883
is version of: GO:0031434
fast: false
reversible: false
name: binding of MEK-P and MEK phosphatase
type: Reaction

http://identifiers.org/biomodels.db/BIOMD0000000011#_0d874bed_c034_429b_bd1f_1ec28936968e
stoichiometry: 1.0
species: 191581
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000011#ab5b51f2_d088_4b26_9df6_4e2d03c85cd1
stoichiometry: 1.0
species: 191661
type: SpeciesReference

972081
value: 0.1
type: LocalParameter

972053
value: 10.0
type: LocalParameter

http://identifiers.org/biomodels.db/BIOMD0000000011#aafab335_8be6_47a4_a985_f9e5729160c2
stoichiometry: 1.0
species: 191461
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000011#_0fc1497b_c76b_4900_9655_80a7d6470eb3
stoichiometry: 1.0
species: 191361
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000011#a4556bf5_9cc7_4f6d_b2df_62aa6027f691
stoichiometry: 1.0
species: 191361
type: SpeciesReference

192022
is version of: GO:0043241
fast: false
reversible: false
name: dissociation of MEK-PP_MEKPase
type: Reaction

http://identifiers.org/biomodels.db/BIOMD0000000011#_6fb40b4f_9209_467e_81e8_00c492096803
stoichiometry: 1.0
species: 191541
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000011#_4ca6c421_0ed5_4b91_9a97_086ee4fdb771
stoichiometry: 1.0
species: 191301
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000011#ded10df3_ac62_427b_a29c_8ef27f24c48e
stoichiometry: 1.0
species: 191521
type: SpeciesReference

191541
has only substance units: true
has part: Q05116
constant: false
boundary condition: false
in compartment: 191248
initial concentration: NaN
initial amount: 0.0
type: Species
has part: P09560
name: MEK-P_RAF-P

http://identifiers.org/biomodels.db/BIOMD0000000011#a98a6414_1c44_4051_9ff5_6aa6ffb9dd76
stoichiometry: 1.0
species: 191281
type: SpeciesReference

191843
is version of: GO:0043241
fast: false
reversible: false
name: dissociation of MEK_RAF-P
type: Reaction

191521
has part: Q05116
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 191248
name: MEK-PP_MEKPase
type: Species

972093
value: 0.1
type: LocalParameter

972069
value: 0.1
type: LocalParameter

972079
value: 0.4
type: LocalParameter

http://identifiers.org/biomodels.db/BIOMD0000000011#_8106062d_5d4f_4a6f_9112_ec383728cdc3
stoichiometry: 1.0
species: 191281
type: SpeciesReference

191401
has part: P26696
initial concentration: NaN
has only substance units: true
initial amount: 0.0
boundary condition: false
type: Species
name: MAPK-PP_MAPKPase
has part: Q90W58
in compartment: 191248
constant: false

191281
has part: Q05116
has part: P26696
initial concentration: NaN
in compartment: 191248
has only substance units: true
type: Species
initial amount: 0.0
constant: false
name: MAPK_MEK-PP
boundary condition: false

191501
is version of: Q05116
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 191248
name: MEK-PP
type: Species

http://identifiers.org/biomodels.db/BIOMD0000000011#_72963df5_2143_466e_ac5e_c3832a7e1f95
stoichiometry: 1.0
species: 191621
type: SpeciesReference

192262
is version of: GO:0043241
fast: false
reversible: false
name: dissociation of MAPK-PP_MAPKPase
type: Reaction

191902
is version of: GO:0043241
fast: false
reversible: false
name: dissociation of MEK-P_MEKPase
type: Reaction

191581
is version of: P09560
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.3
in compartment: 191248
name: RAF
type: Species

191803
type: Reaction
name: dephosphorylation of RAF-P
is version of: http://identifiers.org/ec-code/3.1.3.16
reversible: false
fast: false
is version of: GO:0006470
is version of: GO:0051390

191481
has part: Q05116
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 191248
name: MEK-P_MEKPase
type: Species

http://identifiers.org/biomodels.db/BIOMD0000000011#_12e24e20_6562_4c4b_9d25_456fcbdf5e8a
stoichiometry: 1.0
species: 191501
type: SpeciesReference

191461
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.2
in compartment: 191248
name: MEK phosphatase
type: Species

http://identifiers.org/biomodels.db/BIOMD0000000011#_07eb2587_6ee8_4658_8151_f664e2f3b08f
stoichiometry: 1.0
species: 191401
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000011#c01fe4e9_ff2b_4975_a93f_6c1b60eaa720
stoichiometry: 1.0
species: 191381
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000011#_8a70cde2_1bca_4245_89b5_c24cf879196d
exponent: 1.0
scale: -6
multipler: 1.0
kind: MOLE
type: SBMLUnit

191561
type: Species
has only substance units: true
initial amount: 0.0
has part: P09560
has part: Q05116
in compartment: 191248
constant: false
boundary condition: false
initial concentration: NaN
name: MEK_RAF-P

191421
is version of: Q05116
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.2
in compartment: 191248
name: MEK
type: Species

http://identifiers.org/biomodels.db/BIOMD0000000011#_80c23361_7b2e_48be_94b6_a692f61f56a9
stoichiometry: 1.0
species: 191621
type: SpeciesReference

191441
is version of: Q05116
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 191248
name: MEK-P
type: Species

191943
is version of: GO:0031435
is version of: GO:0031434
fast: false
is homolog to: REACT 143
reversible: false
type: Reaction
name: binding of MEK-P and RAF-P

972091
value: 0.4
type: LocalParameter

972067
value: 0.8
type: LocalParameter

http://identifiers.org/biomodels.db/BIOMD0000000011#a7c82041_0810_4280_8178_e5744af95767
stoichiometry: 1.0
species: 191541
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000011#_29441386_39f1_464f_94a3_ee40d1aecd5b
stoichiometry: 1.0
species: 191461
type: SpeciesReference

972039
value: 0.1
type: LocalParameter

972041
value: 0.5
type: LocalParameter

http://identifiers.org/biomodels.db/BIOMD0000000011#_482d3fbe_023e_4339_ba5d_16420b52191b
stoichiometry: 1.0
species: 191321
type: SpeciesReference

http://identifiers.org/biomodels.db/BIOMD0000000011#_33dd5aeb_6530_40f8_abd9_709c983f3507
stoichiometry: 1.0
species: 191621
type: SpeciesReference

972051
value: 0.1
type: LocalParameter

http://identifiers.org/biomodels.db/BIOMD0000000011#_46e3a71e_39de_4688_9c70_c88e9e574ebc
stoichiometry: 1.0
species: 191501
type: SpeciesReference