361270
stoichiometry: 1.0
species: 060603
type: SpeciesReference

060591
is: GO:0005623
constant: true
units: volume
size: 1.0
spatial dimensions: 3.0
name: cell
type: Compartment

060823
kinetic law: 361464
product: 361452
reactant: 361440
fast: false
reversible: false
name: deactivation of cyclin protease
type: Reaction

873773
constant: false
value: NaN
name: V1
type: Parameter

060683
constant: false
boundary condition: false
has only substance units: false
substance units: substance
initial concentration: 0.99
initial amount: NaN
in compartment: 060591
name: Inactive Cyclin Protease
type: Species

060803
kinetic law: 361428
product: 361416
reactant: 361404
fast: false
reversible: false
name: activation of cyclin protease
type: Reaction

361416
stoichiometry: 1.0
species: 060643
type: SpeciesReference

060603
boundary condition: false
type: Species
has only substance units: false
initial amount: NaN
initial concentration: 0.01
name: Cyclin
substance units: substance
in compartment: 060591
constant: false
is version of: IPR006670

873776
constant: true
value: 3.0
name: VM1
type: Parameter

873774
constant: false
value: NaN
name: V3
type: Parameter

873760
value: 0.005
type: LocalParameter

361440
stoichiometry: 1.0
species: 060643
type: SpeciesReference

873755
value: 0.025
type: LocalParameter

873759
value: 0.02
type: LocalParameter

873765
value: 0.005
type: LocalParameter

873761
value: 1.5
type: LocalParameter

060783
reversible: false
is version of: GO:0045736
type: Reaction
kinetic law: 361392
reactant: 361368
product: 361380
is version of: http://identifiers.org/ec-code/2.7.10.2
is version of: GO:0006468
fast: false
name: deactivation of cdc2 kinase

873758
value: 0.25
type: LocalParameter

361332
stoichiometry: 1.0
species: 060663
type: SpeciesReference

873777
constant: true
value: 1.0
name: VM3
type: Parameter

361246
stoichiometry: 1.0
species: 060603
type: SpeciesReference

060763
is version of: http://identifiers.org/ec-code/3.1.3.16
is version of: GO:0006470
reversible: false
name: activation of cdc2 kinase
reactant: 361332
is version of: GO:0045737
fast: false
type: Reaction
kinetic law: 361356
product: 361344

873768
value: 0.5
type: LocalParameter

060623
type: Species
in compartment: 060591
has only substance units: false
initial concentration: 0.01
boundary condition: false
has version: P35567
has version: P24033
constant: false
name: Active CDC-2 Kinase
substance units: substance
initial amount: NaN

060643
constant: false
boundary condition: false
has only substance units: false
substance units: substance
initial concentration: 0.01
initial amount: NaN
in compartment: 060591
name: Active Cyclin Protease
type: Species

060723
kinetic law: 361282
reactant: 361270
is version of: GO:0008054
fast: false
reversible: false
name: default degradation of cyclin
type: Reaction

873762
value: 0.005
type: LocalParameter

060663
initial concentration: 0.99
initial amount: NaN
type: Species
has version: P35567
constant: false
in compartment: 060591
boundary condition: false
substance units: substance
name: Inactive CDC-2 Kinase
has only substance units: false
has version: P24033

361452
stoichiometry: 1.0
species: 060683
type: SpeciesReference

361404
stoichiometry: 1.0
species: 060683
type: SpeciesReference

060703
kinetic law: 361258
product: 361246
is version of: GO:0006412
fast: false
reversible: false
name: creation of cyclin
type: Reaction

BIOMD0000000004
parameter: 873774
length unit: length
type: SBMLModel
parameter: 873778
reaction: 060703
modified:
  W3 CDTF: Tue Dec 11 15:30:15 GMT 2012
reaction: 060743
created:
  W3 CDTF: Tue Feb 08 17:34:02 GMT 2005
reaction: 060763
species: 060603
substance units: substance
is homolog to: REACT 152
species: 060663
reaction: 060723
area units: area
volume units: volume
is: MODEL6614389071
parameter: 873776
is version of: GO:0000278
reaction: 060823
species: 060643
rule: rule2
parameter: 873773
species: 060623
name: Goldbeter1991 - Min Mit Oscil, Expl Inact
notes: Goldbeter1991 - Min Mit Oscil, Expl Inact This model represents the inactive forms of CDC-2 Kinase and Cyclin Protease as separate species, unlike the ODEs in the published paper, in which the equations for the inactive forms are substituted into the equations for the active forms using a mass conservation rule M+MI=1,X+XI=1. Mass is still conserved in this model through the explicit reactions M<->MI and X<->XI. The terms in the kinetic laws are identical to the corresponding terms in the kinetic laws in the published paper. This model has been generated by MathSBML 2.4.6 (14-January-2005) 14-January-2005 18:37:35.503857. This model is described in the article: A minimal cascade model for the mitotic oscillator involving cyclin and cdc2 kinase. Goldbeter A. Proc. Natl. Acad. Sci. USA 1991 Oct; 88(20):9107-11 Abstract: A minimal model for the mitotic oscillator is presented. The model, built on recent experimental advances, is based on the cascade of post-translational modification that modulates the activity of cdc2 kinase during the cell cycle. The model pertains to the situation encountered in early amphibian embryos, where the accumulation of cyclin suffices to trigger the onset of mitosis. In the first cycle ofthe bicyclic cascade model, cyclin promotes the activation of cdc2 kinase through reversible dephosphorylation, and in the second cycle, cdc2 kinase activates a cyclin protease by reversible phosphorylation. That cyclin activates cdc2 kinase while the kinase triggers the degradation of cyclin has suggested that oscillations may originate from such a negative feedback loop [Félix, M. A., Labbé, J. C., Dorée, M., Hunt, T. & Karsenti, E. (1990) Nature (London) 346, 379-382]. Thisconjecture is corroborated by the model, which indicates that sustained oscillations of the limit cycle type can arise in the cascade, provided that a threshold exists in the activation of cdc2 kinase by cyclin and in the activation of cyclinproteolysis by cdc2 kinase. The analysis sh…
parameter: 873777
curated: true
compartment: 060591
species: 060683
time units: time
reaction: 060803
is version of: hsa04110
reaction: 060783
creator:
  ORG:
    orgname: NASA Jet Propulsion Laboratory
  n:
    given: Bruce
    family: Shapiro
is described by: http://identifiers.org/pubmed/1833774
is derived from: BIOMD0000000003
rule: rule1
occurs in: http://identifiers.org/taxonomy/8292

873778
constant: true
value: 0.5
name: Kc
type: Parameter

060743
kinetic law: 361319
modifier: 361307
reactant: 361294
is version of: GO:0008054
fast: false
reversible: false
name: cdc2 kinase triggered degration of cyclin
type: Reaction

873763
value: 0.005
type: LocalParameter

873757
value: 0.01
type: LocalParameter

361368
stoichiometry: 1.0
species: 060623
type: SpeciesReference

361344
stoichiometry: 1.0
species: 060623
type: SpeciesReference

361380
stoichiometry: 1.0
species: 060663
type: SpeciesReference

361294
stoichiometry: 1.0
species: 060603
type: SpeciesReference