961168
is: SBO:0000022
value: 0.01
type: LocalParameter

961170
is: SBO:0000186
value: 0.25
type: LocalParameter

230615
is version of: http://identifiers.org/ec-code/2.7.10.2
name: deactivation of cdc2 kinase
is version of: GO:0045736
reversible: false
type: Reaction
is: SBO:0000216
fast: false
kinetic law: 356086
is version of: GO:0006468
reactant: 356074

BIOMD0000000003
substance units: substance
is homolog to: REACT 152
reaction: 230535
reaction: 230635
time units: time
creator:
  ORG:
    orgname: NASA Jet Propulsion Laboratory
  n:
    given: Bruce
    family: Shapiro
parameter: 961185
species: 230495
reaction: 230615
occurs in: http://identifiers.org/taxonomy/8292
is described by: http://identifiers.org/pubmed/1833774
species: 230515
name: Goldbeter1991 - Min Mit Oscil
area units: area
is: MODEL6614271263
parameter: 961187
created:
  W3 CDTF: Sun Feb 06 23:39:40 GMT 2005
species: 230475
rule: rule2
parameter: 961186
creator:
  ORG:
    orgname: EMBL-EBI
  n:
    given: Vijayalakshmi
    family: Chelliah
reaction: 230595
is version of: GO:0000278
type: SBMLModel
is version of: hsa04110
length unit: length
reaction: 230655
reaction: 230575
reaction: 230555
notes: Goldbeter1991 - Min Mit Oscil Minimal cascade model for the mitotic oscillator involving cyclin and cdc2 kinase. This model has been generated by MathSBML 2.4.6 (14-January-2005) 14-January-2005 18:33:39.806932. This model is described in the article: A minimal cascade model for the mitotic oscillator involving cyclin and cdc2 kinase. Goldbeter A. Proc. Natl. Acad. Sci. U.S.A. 1991; 88(20):9107-11 Abstract: A minimal model for the mitotic oscillator is presented. The model, built on recent experimental advances, is based on the cascade of post-translational modification that modulates the activity of cdc2 kinase during the cell cycle. The model pertains to the situation encountered in early amphibian embryos, where the accumulation of cyclin suffices to trigger the onset of mitosis. In the first cycle of the bicyclic cascade model, cyclin promotes the activation of cdc2 kinase through reversible dephosphorylation, and in the second cycle, cdc2 kinase activates a cyclin protease by reversible phosphorylation. That cyclin activates cdc2 kinase while the kinase triggers the degradation of cyclin has suggested that oscillations may originate from such a negative feedback loop [Félix, M. A., Labbé, J. C., Dorée, M., Hunt, T. & Karsenti, E. (1990) Nature (London) 346, 379-382]. This conjecture is corroborated by the model, which indicates that sustained oscillations of the limit cycle type can arise in the cascade, provided that a threshold exists in the activation of cdc2 kinase by cyclin and in the activation of cyclin proteolysis by cdc2 kinase. The analysis shows how miototic oscillations may readily arise from time lags associated with these thresholds and from the delayed negative feedback provided by cdc2-induced cyclin degradation. A mechanism for the origin of the thresholds is proposed in terms of the phenomenon of zero-order ultrasensitivity previously described for biochemical systems regulated by covalent modification. This model is hosted on BioModels Databa…
curated: true
parameter: 961190
rule: rule1
compartment: 230461
modified:
  W3 CDTF: Thu May 16 15:38:01 BST 2013
volume units: volume
parameter: 961192

230575
kinetic law: 356038
modifier: 356026
reactant: 356014
is version of: GO:0008054
is: SBO:0000179
fast: false
reversible: false
name: cdc2 kinase triggered degration of cyclin
type: Reaction

961190
is: SBO:0000186
constant: true
value: 1.0
name: VM3
type: Parameter

230635
kinetic law: 356110
product: 356098
is: SBO:0000216
fast: false
reversible: false
name: activation of cyclin protease
type: Reaction

356098
stoichiometry: 1.0
species: 230515
type: SpeciesReference

961171
is: SBO:0000027
value: 0.02
type: LocalParameter

961174
is: SBO:0000027
value: 0.005
type: LocalParameter

961180
is: SBO:0000186
value: 0.5
type: LocalParameter

230475
in compartment: 230461
name: Cyclin
initial concentration: 0.01
is version of: IPR006670
constant: false
initial amount: NaN
boundary condition: false
is version of: Q4KLA0
type: Species
is: SBO:0000252
has only substance units: false
substance units: substance

230555
kinetic law: 356002
reactant: 355990
is version of: GO:0008054
is: SBO:0000179
fast: false
reversible: false
name: default degradation of cyclin
type: Reaction

230495
substance units: substance
initial concentration: 0.01
has version: P35567
boundary condition: false
has version: P24033
in compartment: 230461
has only substance units: false
name: CDC-2 Kinase
type: Species
initial amount: NaN
is: SBO:0000252
constant: false

961167
is: SBO:0000048
value: 0.025
type: LocalParameter

230461
is: GO:0005623
is: SBO:0000290
constant: true
units: volume
size: 1.0
spatial dimensions: 3.0
name: cell
type: Compartment

961177
is: SBO:0000027
value: 0.005
type: LocalParameter

230655
kinetic law: 356134
reactant: 356122
is: SBO:0000330
fast: false
reversible: false
name: deactivation of cyclin protease
type: Reaction

230595
is version of: GO:0006470
name: activation of cdc2 kinase
fast: false
is: SBO:0000330
is version of: http://identifiers.org/ec-code/3.1.3.16
product: 356050
is version of: GO:0045737
type: Reaction
reversible: false
kinetic law: 356062

961187
is: SBO:0000025
constant: true
value: 3.0
name: VM1
type: Parameter

356122
stoichiometry: 1.0
species: 230515
type: SpeciesReference

961173
is: SBO:0000186
value: 1.5
type: LocalParameter

961172
is: SBO:0000027
value: 0.005
type: LocalParameter

230535
kinetic law: 355978
product: 355966
is version of: GO:0006412
is: SBO:0000393
fast: false
reversible: false
name: creation of cyclin
type: Reaction

230515
name: Cyclin Protease
is: SBO:0000297
initial concentration: 0.01
has version: REACT 7165.1
initial amount: NaN
in compartment: 230461
substance units: substance
has only substance units: false
constant: false
is version of: GO:0005680
boundary condition: false
type: Species

961186
is: SBO:0000186
constant: false
value: NaN
name: V3
type: Parameter

961192
is: SBO:0000027
constant: true
value: 0.5
name: Kc
type: Parameter

355990
stoichiometry: 1.0
species: 230475
type: SpeciesReference

356014
stoichiometry: 1.0
species: 230475
type: SpeciesReference

356074
stoichiometry: 1.0
species: 230495
type: SpeciesReference

355966
stoichiometry: 1.0
species: 230475
type: SpeciesReference

961185
is: SBO:0000186
constant: false
value: NaN
name: V1
type: Parameter

356050
stoichiometry: 1.0
species: 230495
type: SpeciesReference

961175
is: SBO:0000027
value: 0.005
type: LocalParameter