351615
stoichiometry: 1.0
species: 764696
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361906
local parameters: 831610
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notes: k1*AMPAR_memb_slash_A845_star__B831_star_845_star_*CaM_Ca_n_minus_CaNAB-k2*CaM_Ca_n_minus_CaNAB_slash_PP2B_sbo_9_sbc__slash_PP2B_sbo_9_sbc__cplx
type: KineticLaw

352792
local parameters: 830766
local parameters: 830763
notes: k1*cAMP*AC_slash_cAMP_minus_PDE_star_-k2*AC_slash_cAMP_minus_PDE_star__slash_PDE_star__slash_PDE_star__cplx
type: KineticLaw

830004
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value: 4.65012E-18
type: LocalParameter

830814
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value: 2.0E-17
type: LocalParameter

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boundary condition: false
has only substance units: false
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initial amount: NaN
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348488
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species: 763956
type: SpeciesReference

360880
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species: 767636
type: SpeciesReference

347979
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notes: k3*PP1_minus_active_slash_Deph_minus_thr305_slash_Deph_minus_thr305_cplx
type: KineticLaw

830133
units: 344978
value: 0.0
type: LocalParameter

346255
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species: 765456
type: SpeciesReference

830950
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value: 2.77776E-19
type: LocalParameter

351481
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notes: k3*PKA_minus_active_slash_PKA_sbo_14_sbc__slash_PKA_sbo_14_sbc__cplx
type: KineticLaw

830172
units: 345062
value: 4.9998E-15
type: LocalParameter

830892
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value: 2.0E-17
type: LocalParameter

361254
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species: 768516
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347363
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type: Species

829965
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value: 9.0E-18
type: LocalParameter

775155
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product: 358339
product: 358327
reactant: 358315
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reversible: false
type: Reaction

353818
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species: 768656
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350882
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354070
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species: 768556
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361677
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species: 768616
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355158
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notes: k3*PP1_minus_active_PSD_slash_Deph_minus_thr305_slash_Deph_minus_thr305_cplx
type: KineticLaw

347579
local parameters: 830271
local parameters: 830268
notes: kf*PKC_minus_control-kb*PKC_minus_active
type: KineticLaw

352646
local parameters: 830751
local parameters: 830748
notes: kcat*AC_slash_AC2_star_*AC_slash_ATP/(Km+AC_slash_ATP)
type: KineticLaw

830529
units: 344978
value: 2.16E-15
type: LocalParameter

361810
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local parameters: 831598
notes: k1*AMPAR_memb_slash_A845_star__B831_star_845_star_*CaM_Ca_n_minus_CaNAB-k2*CaM_Ca_n_minus_CaNAB_slash_PP2B_sbo_8_sbc__slash_PP2B_sbo_8_sbc__cplx
type: KineticLaw

831148
units: 345062
value: 8.7498E-18
type: LocalParameter

355558
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species: 768656
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357990
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357374
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species: 766376
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354624
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local parameters: 830932
notes: k1*AMPAR_memb_slash_A831_star__B845_star_*actCaMKII_minus_PSD-k2*actCaMKII_minus_PSD_slash_CaMKII_sbo_13_sbc__slash_CaMKII_sbo_13_sbc__cplx
type: KineticLaw

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774555
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reversible: false
type: Reaction

771716
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product: 349322
product: 349310
reactant: 349298
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reversible: false
type: Reaction

348996
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local parameters: 830409
notes: k1*AMPAR_slash_A831_star__B*PKA_minus_active-k2*PKA_minus_active_slash_PKA_sbo_21_sbc__slash_PKA_sbo_21_sbc__cplx
type: KineticLaw

773596
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product: 353890
product: 353878
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reversible: false
type: Reaction

830280
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value: 1.0E-17
type: LocalParameter

770396
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product: 346291
reactant: 346279
notes: Random rate.
fast: false
reversible: true
type: Reaction

358315
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species: 767096
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776915
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product: 362610
reactant: 362598
fast: false
reversible: false
type: Reaction

830742
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value: 4.05E-16
type: LocalParameter

362247
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notes: k3*CaM_Ca_n_minus_CaNAB_slash_PP2B_sbo_12_sbc__slash_PP2B_sbo_12_sbc__cplx
type: KineticLaw

350012
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notes: k3*PKA_minus_active_slash_PKA_sbo_31_sbc__slash_PKA_sbo_31_sbc__cplx
type: KineticLaw

360504
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notes: k3*CaM_Ca_n_minus_CaNAB_slash_PP2B_sbo_27_sbc__slash_PP2B_sbo_27_sbc__cplx
type: KineticLaw

353746
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species: 766056
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830007
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831658
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value: 1.8E-16
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360264
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local parameters: 831454
notes: k1*AMPAR_slash_A845_star__B845_star_*CaM_Ca_n_minus_CaNAB-k2*CaM_Ca_n_minus_CaNAB_slash_PP2B_sbo_25_sbc__slash_PP2B_sbo_25_sbc__cplx
type: KineticLaw

354563
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species: 769136
type: SpeciesReference

830700
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value: 7.50006E-16
type: LocalParameter

767296
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initial amount: NaN
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type: Species

773516
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product: 353686
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reversible: false
type: Reaction

357614
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species: 766956
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830781
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type: LocalParameter

831082
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value: 3.5E-18
type: LocalParameter

348319
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notes: k1*PP1_slash_I1*PKA_minus_active-k2*PKA_minus_active_slash_PKA_minus_phosph_minus_I1_slash_PKA_minus_phosph_minus_I1_cplx
type: KineticLaw

353094
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species: 765836
type: SpeciesReference

767396
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boundary condition: false
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initial concentration: 0.0
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type: Species

764456
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type: Species

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boundary condition: true
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type: Species

352076
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species: 765036
type: SpeciesReference

775475
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product: 359139
product: 359127
reactant: 359115
fast: false
reversible: false
type: Reaction

346762
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species: 765936
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356533
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species: 768796
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362319
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350955
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species: 764456
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830175
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value: 1.0E-18
type: LocalParameter

772336
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product: 350832
reactant: 350820
reactant: 350808
fast: false
reversible: true
type: Reaction

831697
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value: 3.12498E-19
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358520
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species: 764836
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829968
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value: 6.47990604E-15
type: LocalParameter

352329
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species: 766356
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358849
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notes: k3*PKC_minus_active_slash_PKC_minus_phosph_minus_neurogranin_PSD_slash_PKC_minus_phosph_minus_neurogranin_PSD_cplx
type: KineticLaw

766276
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boundary condition: false
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initial amount: NaN
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346147
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347255
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species: 768896
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831145
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value: 1.7E-18
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351591
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initial amount: NaN
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type: Species

830091
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value: 9.0E-17
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354515
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species: 766216
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831250
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value: 1.4E-17
type: LocalParameter

349056
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species: 767516
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348670
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776675
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reversible: false
type: Reaction

350615
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347291
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352682
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species: 765576
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830706
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value: 6.4584E-18
type: LocalParameter

354202
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species: 768736
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361786
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species: 767636
type: SpeciesReference

830427
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value: 3.5998992E-16
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345967
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species: 765316
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771276
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reversible: false
type: Reaction

830811
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value: 8.0E-17
type: LocalParameter

347893
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species: 764656
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352938
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notes: k3*AC_slash_PDE1_slash_PDE1_slash_PDE1_cplx
type: KineticLaw

357266
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species: 768656
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765396
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353214
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357506
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species: 764057
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831085
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value: 8.7498E-18
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776315
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reversible: false
type: Reaction

361894
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species: 768256
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830784
units: 344978
value: 3.6E-15
type: LocalParameter

355497
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local parameters: 831013
notes: k1*AMPAR_memb_slash_A845_star__B*PP1_minus_active_PSD-k2*PP1_minus_active_PSD_slash_PP1_sbo_2_sbc__slash_PP1_sbo_2_sbc__cplx
type: KineticLaw

831211
units: 345062
value: 8.7498E-18
type: LocalParameter

774336
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product: 355778
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fast: false
reversible: true
type: Reaction

772556
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product: 351370
product: 351358
reactant: 351346
fast: false
reversible: false
type: Reaction

351968
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notes: k3*CaMKII_slash_tot_autonomous_CaMKII_slash_auton_286_slash_auton_286_cplx
type: KineticLaw

358207
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local parameters: 831265
notes: k1*AMPAR_memb_slash_A831_star_845_star__B831_star_*PP1_minus_active_PSD-k2*PP1_minus_active_PSD_slash_PP1_sbo_30_sbc__slash_PP1_sbo_30_sbc__cplx
type: KineticLaw

773896
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fast: false
reversible: true
type: Reaction

830745
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value: 299.9976000192
type: LocalParameter

830130
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value: 1.08E-20
type: LocalParameter

348948
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notes: k3*PKA_minus_active_slash_PKA_sbo_20_sbc__slash_PKA_sbo_20_sbc__cplx
type: KineticLaw

345240
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species: 764676
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830283
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value: 1.0E-17
type: LocalParameter

773856
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fast: false
reversible: true
type: Reaction

352148
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358171
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355620
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346448
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359623
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species: 767636
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830094
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value: 9.0E-18
type: LocalParameter

349770
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local parameters: 830481
notes: k1*AMPAR_slash_A831_star_845_star__B*PKA_minus_active-k2*PKA_minus_active_slash_PKA_sbo_29_sbc__slash_PKA_sbo_29_sbc__cplx
type: KineticLaw

774335
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product: 355730
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reversible: false
type: Reaction

350121
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species: 768596
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353854
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notes: k1*AMPAR_memb_slash_A_B845_star_*actCaMKII_minus_PSD-k2*actCaMKII_minus_PSD_slash_CaMKII_sbo_5_sbc__slash_CaMKII_sbo_5_sbc__cplx
type: KineticLaw

351284
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notes: k3*PKA_minus_active_slash_PKA_sbo_12_sbc__slash_PKA_sbo_12_sbc__cplx
type: KineticLaw

348089
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774056
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fast: false
reversible: true
type: Reaction

830703
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value: 1.8E-16
type: LocalParameter

349879
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species: 764236
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774016
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product: 354903
reactant: 354891
reactant: 354879
fast: false
reversible: true
type: Reaction

830424
units: 344978
value: 5.4E-16
type: LocalParameter

360540
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species: 767976
type: SpeciesReference

831469
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value: 1.8E-16
type: LocalParameter

346039
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species: 763916
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353106
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species: 765816
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353962
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348199
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species: 763956
type: SpeciesReference

831100
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value: 3.5E-18
type: LocalParameter

361858
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notes: k3*CaM_Ca_n_minus_CaNAB_slash_PP2B_sbo_8_sbc__slash_PP2B_sbo_8_sbc__cplx
type: KineticLaw

355386
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species: 766496
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356356
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species: 766696
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356605
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species: 766376
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value: 9.0E-16
type: LocalParameter

766496
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boundary condition: false
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initial concentration: 0.0
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in compartment: 763776
type: Species

344954
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scale: 0
multipler: 1.0
kind: LITRE
type: SBMLUnit

349165
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species: 763956
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830352
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value: 8.1E-16
type: LocalParameter

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value: 9.0E-17
type: LocalParameter

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species: 764516
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831508
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value: 1.8106416E-16
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355874
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species: 766596
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830709
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value: 7.50006E-16
type: LocalParameter

350723
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356689
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species: 768556
type: SpeciesReference

830235
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value: 0.0
type: LocalParameter

830577
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value: 5.4E-16
type: LocalParameter

355935
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notes: k3*PP1_minus_active_PSD_slash_PP1_sbo_6_sbc__slash_PP1_sbo_6_sbc__cplx
type: KineticLaw

765716
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831547
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type: LocalParameter

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value: 8.7498E-18
type: LocalParameter

348524
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species: 764017
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774695
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reactant: 357217
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fast: false
reversible: true
type: Reaction

831652
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value: 2.011824E-17
type: LocalParameter

353409
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species: 769136
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770716
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fast: false
reversible: true
type: Reaction

353638
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831253
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value: 2.16E-15
type: LocalParameter

354709
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351541
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notes: k1*AMPAR_memb_slash_A831_star_845_star__B*PP1_minus_active_PSD-k2*PP1_minus_active_PSD_slash_PP1_sbo_10_sbc__slash_PP1_sbo_10_sbc__cplx
type: KineticLaw

346616
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local parameters: 830136
notes: kf*CaMKII_minus_PSD-kb*CaMKII_slash_CaMKII*NMDAR
type: KineticLaw

771636
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reactant: 349105
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reversible: false
type: Reaction

831505
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value: 1.8E-16
type: LocalParameter

768076
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345726
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830998
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value: 6.8E-18
type: LocalParameter

349660
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774755
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product: 357362
reactant: 357350
fast: false
reversible: false
type: Reaction

357326
stoichiometry: 1.0
species: 766896
type: SpeciesReference

359985
stoichiometry: 1.0
species: 767856
type: SpeciesReference

775795
kinetic law: 359925
product: 359913
product: 359901
reactant: 359889
fast: false
reversible: false
type: Reaction

763744
constant: true
size: 1.0E-18
spatial dimensions: 3.0
type: Compartment

771176
kinetic law: 348027
product: 348015
reactant: 348003
reactant: 347991
fast: false
reversible: true
type: Reaction

831256
units: 345062
value: 8.7498E-18
type: LocalParameter

770516
kinetic law: 346568
product: 346556
reactant: 346544
reactant: 346532
notes: Same as for transloc_1
fast: false
reversible: true
type: Reaction

773056
kinetic law: 352597
modifier: 352585
product: 352572
reactant: 352559
notes: 17 Feb 2005 Halved Vmax as the amount of enzyme has been doubled to get an integer value in the spine. 18 Feb 2005. Updated Km from BRENDA: EC No 4.6.1.1 Rat Km: 0.95 mM Turnover 12/sec. Human Km: 0.3 mM 12 umol/min/mg for mammalia, turnover is 12/sec See PMID 8663304 by Dessauer and Gilman JBC 271 1996 Unfortunately turnover range is from 34 down to 0.1 in different studies, according to BRENDA.
fast: false
reversible: false
type: Reaction

776095
kinetic law: 360650
product: 360638
reactant: 360626
reactant: 360614
fast: false
reversible: true
type: Reaction

352719
stoichiometry: 1.0
species: 765536
type: SpeciesReference

776055
kinetic law: 360553
product: 360540
reactant: 360528
reactant: 360516
fast: false
reversible: true
type: Reaction

351858
stoichiometry: 1.0
species: 769056
type: SpeciesReference

768456
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 763776
type: Species

345666
stoichiometry: 1.0
species: 764936
type: SpeciesReference

831103
units: 345062
value: 8.7498E-18
type: LocalParameter

831544
units: 345062
value: 2.011824E-17
type: LocalParameter

349563
stoichiometry: 1.0
species: 764177
type: SpeciesReference

361049
stoichiometry: 1.0
species: 768076
type: SpeciesReference

358243
stoichiometry: 1.0
species: 766376
type: SpeciesReference

358994
stoichiometry: 1.0
species: 767656
type: SpeciesReference

765796
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 763776
type: Species

347531
stoichiometry: 1.0
species: 765796
type: SpeciesReference

358062
local parameters: 831253
notes: k3*PP1_minus_active_PSD_slash_PP1_sbo_28_sbc__slash_PP1_sbo_28_sbc__cplx
type: KineticLaw

352257
local parameters: 830712
notes: k3*PP2A_slash_PP2A_minus_dephosph_minus_I1_PSD_slash_PP2A_minus_dephosph_minus_I1_PSD_cplx
type: KineticLaw

358800
local parameters: 831322
local parameters: 831319
notes: k1*CaM_slash_neurogranin_PSD*PKC_minus_active-k2*PKC_minus_active_slash_PKC_minus_phosph_minus_neurogranin_PSD_slash_PKC_minus_phosph_minus_neurogranin_PSD_cplx
type: KineticLaw

774076
kinetic law: 355060
product: 355048
product: 355036
reactant: 355024
fast: false
reversible: false
type: Reaction

769336
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 763776
type: Species

831598
units: 345062
value: 2.011824E-17
type: LocalParameter

362198
local parameters: 831637
local parameters: 831634
notes: k1*AMPAR_memb_slash_A835_star_845_star__B835_star_845_star_*CaM_Ca_n_minus_CaNAB-k2*CaM_Ca_n_minus_CaNAB_slash_PP2B_sbo_12_sbc__slash_PP2B_sbo_12_sbc__cplx
type: KineticLaw

765756
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 763776
type: Species

352854
stoichiometry: 1.0
species: 763916
type: SpeciesReference

347027
stoichiometry: 1.0
species: 768556
type: SpeciesReference

360215
local parameters: 831451
notes: k3*CaM_Ca_n_minus_CaNAB_slash_PP2B_sbo_24_sbc__slash_PP2B_sbo_24_sbc__cplx
type: KineticLaw

831142
units: 344978
value: 6.8E-18
type: LocalParameter

353385
stoichiometry: 1.0
species: 765976
type: SpeciesReference

830859
units: 344978
value: 5.0E-18
type: LocalParameter

354370
stoichiometry: 1.0
species: 769136
type: SpeciesReference

350845
local parameters: 830583
local parameters: 830580
notes: k1*AMPAR_memb_slash_A_B831_star_845_star_*PKA_minus_active-k2*PKA_minus_active_slash_PKA_sbo_8_sbc__slash_PKA_sbo_8_sbc__cplx
type: KineticLaw

766956
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 763776
type: Species

831430
units: 344978
value: 7.2E-16
type: LocalParameter

353445
stoichiometry: 1.0
species: 769136
type: SpeciesReference

831259
units: 344978
value: 1.4E-17
type: LocalParameter

361363
stoichiometry: 1.0
species: 767636
type: SpeciesReference

764256
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 763757
type: Species

349624
local parameters: 830469
notes: k3*PKA_minus_active_slash_PKA_sbo_27_sbc__slash_PKA_sbo_27_sbc__cplx
type: KineticLaw

346690
stoichiometry: 1.0
species: 765936
type: SpeciesReference

771496
kinetic law: 348802
product: 348790
reactant: 348778
reactant: 348766
fast: false
reversible: true
type: Reaction

346931
local parameters: 830181
local parameters: 830178
notes: kf*CaM_minus_Ca3*Ca-kb*CaM_minus_Ca4
type: KineticLaw

770796
kinetic law: 347195
product: 347183
reactant: 347171
fast: false
reversible: true
type: Reaction

354770
local parameters: 830947
notes: k3*actCaMKII_minus_PSD_slash_CaMKII_sbo_14_sbc__slash_CaMKII_sbo_14_sbc__cplx
type: KineticLaw

776895
kinetic law: 362586
product: 362573
reactant: 362561
reactant: 362549
notes: From Seki et al ABB 316(2):673-679
fast: false
reversible: true
type: Reaction

352962
stoichiometry: 1.0
species: 765676
type: SpeciesReference

360917
stoichiometry: 1.0
species: 767636
type: SpeciesReference

771456
kinetic law: 348706
product: 348694
reactant: 348682
reactant: 348670
fast: false
reversible: true
type: Reaction

830995
units: 345062
value: 8.7498E-18
type: LocalParameter

829962
units: 345062
value: 9.001692E-14
type: LocalParameter

830895
units: 344978
value: 5.0E-18
type: LocalParameter

775115
kinetic law: 358255
product: 358243
product: 358231
reactant: 358219
fast: false
reversible: false
type: Reaction

773276
kinetic law: 353130
product: 353118
product: 353106
reactant: 353094
fast: false
reversible: false
type: Reaction

350393
stoichiometry: 1.0
species: 763956
type: SpeciesReference

355266
stoichiometry: 1.0
species: 768696
type: SpeciesReference

361967
stoichiometry: 1.0
species: 768736
type: SpeciesReference

830289
units: 344978
value: 9.0E-17
type: LocalParameter

346363
stoichiometry: 1.0
species: 763796
type: SpeciesReference

362355
stoichiometry: 1.0
species: 768636
type: SpeciesReference

831592
units: 344978
value: 7.2E-16
type: LocalParameter

360856
stoichiometry: 1.0
species: 768036
type: SpeciesReference

356965
stoichiometry: 1.0
species: 766816
type: SpeciesReference

764976
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 763757
type: Species

350991
local parameters: 830595
notes: k3*PKA_minus_active_slash_PKA_sbo_9_sbc__slash_PKA_sbo_9_sbc__cplx
type: KineticLaw

356019
stoichiometry: 1.0
species: 766376
type: SpeciesReference

831541
units: 344978
value: 1.8E-16
type: LocalParameter

830178
units: 345062
value: 4.1849946E-17
type: LocalParameter

350341
stoichiometry: 1.0
species: 764336
type: SpeciesReference

830460
units: 344978
value: 5.4E-16
type: LocalParameter

360324
stoichiometry: 1.0
species: 767416
type: SpeciesReference

354987
stoichiometry: 1.0
species: 766376
type: SpeciesReference

351015
stoichiometry: 1.0
species: 763956
type: SpeciesReference

764196
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 763757
type: Species

359949
stoichiometry: 1.0
species: 767636
type: SpeciesReference

352100
stoichiometry: 1.0
species: 765116
type: SpeciesReference

831595
units: 344978
value: 1.8E-16
type: LocalParameter

768716
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 763776
type: Species

773336
kinetic law: 353276
product: 353264
reactant: 353252
reactant: 353240
fast: false
reversible: true
type: Reaction

357434
local parameters: 831196
local parameters: 831193
notes: k1*AMPAR_memb_slash_A845_star__B831_star_*PP1_minus_active_PSD-k2*PP1_minus_active_PSD_slash_PP1_sbo_22_sbc__slash_PP1_sbo_22_sbc__cplx
type: KineticLaw

768756
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 763776
type: Species

353926
stoichiometry: 1.0
species: 769136
type: SpeciesReference

831190
units: 344978
value: 3.5E-18
type: LocalParameter

357917
local parameters: 831241
local parameters: 831238
notes: k1*AMPAR_memb_slash_A831_star__B831_star_*PP1_minus_active_PSD-k2*PP1_minus_active_PSD_slash_PP1_sbo_27_sbc__slash_PP1_sbo_27_sbc__cplx
type: KineticLaw

345594
stoichiometry: 1.0
species: 765936
type: SpeciesReference

774975
kinetic law: 357917
product: 357905
reactant: 357893
reactant: 357881
fast: false
reversible: true
type: Reaction

354034
stoichiometry: 1.0
species: 766116
type: SpeciesReference

354975
stoichiometry: 1.0
species: 765776
type: SpeciesReference

359259
stoichiometry: 1.0
species: 766316
type: SpeciesReference

775615
kinetic law: 359490
product: 359478
reactant: 359466
reactant: 359454
fast: false
reversible: true
type: Reaction

830856
units: 344978
value: 2.0E-17
type: LocalParameter

347423
stoichiometry: 1.0
species: 768436
type: SpeciesReference

345303
stoichiometry: 2.0
species: 763936
type: SpeciesReference

356641
stoichiometry: 1.0
species: 766376
type: SpeciesReference

831655
units: 344978
value: 7.2E-16
type: LocalParameter

773676
kinetic law: 354094
product: 354082
product: 354070
reactant: 354058
fast: false
reversible: false
type: Reaction

831502
units: 344978
value: 7.2E-16
type: LocalParameter

830898
units: 345062
value: 2.77776E-19
type: LocalParameter

770936
kinetic law: 347495
product: 347483
reactant: 347471
reactant: 347459
notes: Exo rates are scaled from earlier model versions to account for binding of anchor. We have about 200 molecules of anchor in the whole model. Here we select rates to give us a max of about 150 molecules of GluR at the synapse.
fast: false
reversible: true
type: Reaction

830238
units: 345062
value: 1.08E-19
type: LocalParameter

830574
units: 344978
value: 2.16E-15
type: LocalParameter

830817
units: 345062
value: 2.77776E-19
type: LocalParameter

350096
stoichiometry: 1.0
species: 763956
type: SpeciesReference

830992
units: 344978
value: 2.0E-18
type: LocalParameter

765136
constant: false
boundary condition: false
has only substance units: false
initial concentration: 2.21555555555556E-7
initial amount: NaN
in compartment: 763757
type: Species

359295
local parameters: 831367
local parameters: 831364
notes: k1*PP1_PSD_slash_I1_star_*CaM_Ca_n_minus_CaNAB-k2*CaM_Ca_n_minus_CaNAB_slash_dephosph_inhib1_PSD_slash_dephosph_inhib1_PSD_cplx
type: KineticLaw

351333
local parameters: 830628
local parameters: 830625
notes: k1*AMPAR_memb_slash_A831_star_845_star__B831_star_*PKA_minus_active-k2*PKA_minus_active_slash_PKA_sbo_13_sbc__slash_PKA_sbo_13_sbc__cplx
type: KineticLaw

362670
stoichiometry: 1.0
species: 768456
type: SpeciesReference

772836
kinetic law: 352064
product: 352052
product: 352040
reactant: 352028
fast: false
reversible: false
type: Reaction

830580
units: 345062
value: 3.999888E-17
type: LocalParameter

768176
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 763757
type: Species

350303
local parameters: 830532
notes: k3*PKA_minus_active_slash_PKA_sbo_2_sbc__slash_PKA_sbo_2_sbc__cplx
type: KineticLaw

361001
stoichiometry: 1.0
species: 768696
type: SpeciesReference

361327
local parameters: 831556
local parameters: 831553
notes: k1*AMPAR_memb_slash_A845_star__B*CaM_Ca_n_minus_CaNAB-k2*CaM_Ca_n_minus_CaNAB_slash_PP2B_sbo_3_sbc__slash_PP2B_sbo_3_sbc__cplx
type: KineticLaw

362826
local parameters: 831694
notes: k3*tot_minus_CaM_minus_CaMKII_minus_PSD_slash_CaM_minus_act_minus_286_minus_PSD_slash_CaM_minus_act_minus_286_minus_PSD_cplx
type: KineticLaw

764356
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 763757
type: Species

360807
stoichiometry: 1.0
species: 767436
type: SpeciesReference

765536
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 763757
type: Species

362718
stoichiometry: 1.0
species: 769456
type: SpeciesReference

830916
units: 345062
value: 2.77776E-19
type: LocalParameter

349334
local parameters: 830442
notes: k3*PKA_minus_active_slash_PKA_sbo_24_sbc__slash_PKA_sbo_24_sbc__cplx
type: KineticLaw

774595
kinetic law: 356857
product: 356845
reactant: 356833
reactant: 356821
fast: false
reversible: true
type: Reaction

772016
kinetic law: 350060
product: 350048
reactant: 350036
reactant: 350024
fast: false
reversible: true
type: Reaction

347327
stoichiometry: 1.0
species: 768436
type: SpeciesReference

766136
constant: false
boundary condition: false
has only substance units: false
initial concentration: 4.06666666666667E-215
initial amount: NaN
in compartment: 763776
type: Species

351430
local parameters: 830637
local parameters: 830634
notes: k1*AMPAR_memb_slash_A831_star__B831_star_*PKA_minus_active-k2*PKA_minus_active_slash_PKA_sbo_14_sbc__slash_PKA_sbo_14_sbc__cplx
type: KineticLaw

831550
units: 344978
value: 1.8E-16
type: LocalParameter

831421
units: 344978
value: 7.2E-16
type: LocalParameter

358677
stoichiometry: 1.0
species: 767136
type: SpeciesReference

768976
constant: true
boundary condition: true
has only substance units: false
initial concentration: 0.08
initial amount: NaN
in compartment: 763776
type: Species

767256
constant: false
boundary condition: false
has only substance units: false
initial concentration: 3.5
initial amount: NaN
in compartment: 763776
type: Species

360432
stoichiometry: 1.0
species: 767636
type: SpeciesReference

773556
kinetic law: 353806
product: 353794
product: 353782
reactant: 353770
fast: false
reversible: false
type: Reaction

831472
units: 345062
value: 1.8106416E-16
type: LocalParameter

362076
stoichiometry: 1.0
species: 767636
type: SpeciesReference

770036
kinetic law: 345460
product: 345448
reactant: 345436
notes: This is put in to keep the basal levels of neurogranin* experimentally reasonable. From various papers, specially Ramakers et al JBC 270:23 1995 13892-13898, it looks like the basal level of phosph is between 20 and 40%. I est around 25 % The kf of 0.005 gives around this level at basal PKC activity levels of 0.1 uM active PKC.
fast: false
reversible: true
type: Reaction

361448
stoichiometry: 1.0
species: 768716
type: SpeciesReference

831040
units: 345062
value: 8.7498E-18
type: LocalParameter

355658
stoichiometry: 1.0
species: 768776
type: SpeciesReference

350170
stoichiometry: 1.0
species: 764296
type: SpeciesReference

360965
stoichiometry: 1.0
species: 767576
type: SpeciesReference

766096
constant: false
boundary condition: false
has only substance units: false
initial concentration: 3.588E-215
initial amount: NaN
in compartment: 763776
type: Species

764836
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 763757
type: Species

830349
units: 344978
value: 3.24E-15
type: LocalParameter

348742
stoichiometry: 1.0
species: 763956
type: SpeciesReference

830055
units: 344978
value: 2.97E-15
type: LocalParameter

358776
stoichiometry: 1.0
species: 767136
type: SpeciesReference

830454
units: 345062
value: 3.5998992E-16
type: LocalParameter

355718
stoichiometry: 1.0
species: 768716
type: SpeciesReference

362149
local parameters: 831631
notes: k3*CaM_Ca_n_minus_CaNAB_slash_PP2B_sbo_11_sbc__slash_PP2B_sbo_11_sbc__cplx
type: KineticLaw

767796
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 763757
type: Species

345497
stoichiometry: 1.0
species: 765896
type: SpeciesReference

359151
local parameters: 831352
notes: k3*CaM_Ca_n_minus_CaNAB_slash_dephosph_inhib1_slash_dephosph_inhib1_cplx
type: KineticLaw

357542
stoichiometry: 1.0
species: 766936
type: SpeciesReference

360360
local parameters: 831466
local parameters: 831463
notes: k1*AMPAR_slash_A831_star_845_star__B845_star_*CaM_Ca_n_minus_CaNAB-k2*CaM_Ca_n_minus_CaNAB_slash_PP2B_sbo_26_sbc__slash_PP2B_sbo_26_sbc__cplx
type: KineticLaw

830307
units: 344978
value: 2.25E-16
type: LocalParameter

771756
kinetic law: 349430
product: 349418
product: 349406
reactant: 349394
fast: false
reversible: false
type: Reaction

770076
kinetic law: 345557
product: 345545
reactant: 345533
reactant: 345521
notes: K3 = 21.5, K4 = 2.8. Assuming that the K4 step happens first, we get kb/kf = 2.8 uM = 1.68e6 so kf =6e-6 assuming kb = 10
fast: false
reversible: true
type: Reaction

357482
local parameters: 831199
notes: k3*PP1_minus_active_PSD_slash_PP1_sbo_22_sbc__slash_PP1_sbo_22_sbc__cplx
type: KineticLaw

358738
stoichiometry: 1.0
species: 767136
type: SpeciesReference

351761
stoichiometry: 1.0
species: 769036
type: SpeciesReference

763777
constant: true
size: 5.0E-15
spatial dimensions: 3.0
type: Compartment

764037
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 763757
type: Species

765296
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 763757
type: Species

351737
stoichiometry: 1.0
species: 764716
type: SpeciesReference

345509
local parameters: 829995
local parameters: 829992
notes: kf*CaM_slash_CaM_minus_PSD*Ca_minus_PSD^2-kb*CaM_minus_TR2_minus_Ca2_minus_PSD
type: KineticLaw

350507
local parameters: 830550
notes: k3*PKA_minus_active_slash_PKA_sbo_4_sbc__slash_PKA_sbo_4_sbc__cplx
type: KineticLaw

358122
stoichiometry: 1.0
species: 767056
type: SpeciesReference

766016
constant: false
boundary condition: false
has only substance units: false
initial concentration: 3.588E-215
initial amount: NaN
in compartment: 763776
type: Species

830451
units: 344978
value: 5.4E-16
type: LocalParameter

350483
stoichiometry: 1.0
species: 768776
type: SpeciesReference

830058
units: 345062
value: 6.750054E-15
type: LocalParameter

357845
stoichiometry: 1.0
species: 768676
type: SpeciesReference

350278
stoichiometry: 1.0
species: 768596
type: SpeciesReference

772696
kinetic law: 351725
product: 351713
reactant: 351701
reactant: 351689
fast: false
reversible: true
type: Reaction

357470
stoichiometry: 1.0
species: 766376
type: SpeciesReference

830583
units: 344978
value: 2.16E-15
type: LocalParameter

354879
stoichiometry: 1.0
species: 765736
type: SpeciesReference

775435
kinetic law: 359054
product: 359042
product: 359030
reactant: 359018
fast: false
reversible: false
type: Reaction

354939
stoichiometry: 1.0
species: 765756
type: SpeciesReference

349987
stoichiometry: 1.0
species: 767456
type: SpeciesReference

348151
stoichiometry: 1.0
species: 764596
type: SpeciesReference

345882
local parameters: 830043
local parameters: 830040
notes: kf*CaM_minus_Ca4*CaNAB_minus_Ca4-kb*CaM_Ca_n_minus_CaNAB
type: KineticLaw

772376
kinetic law: 350943
product: 350931
reactant: 350919
reactant: 350907
fast: false
reversible: true
type: Reaction

357121
stoichiometry: 1.0
species: 766376
type: SpeciesReference

772656
kinetic law: 351627
product: 351615
reactant: 351603
reactant: 351591
notes: Rates from autocamtide phosphorylation, from Hanson and Schulman JBC 267:24 17216-17224 1992. Jan 1 1998: Speed up 12x to match fig 5.
fast: false
reversible: true
type: Reaction

831361
units: 344978
value: 3.06E-17
type: LocalParameter

356127
local parameters: 831073
notes: k3*PP1_minus_active_PSD_slash_PP1_sbo_8_sbc__slash_PP1_sbo_8_sbc__cplx
type: KineticLaw

766056
constant: false
boundary condition: false
has only substance units: false
initial concentration: 7.1375E-215
initial amount: NaN
in compartment: 763776
type: Species

764036
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 763757
type: Species

346834
local parameters: 830169
local parameters: 830166
notes: kf*PP1_PSD_slash_PP1_minus_I1-kb*PP1_PSD_slash_I1*PP1_minus_active_PSD
type: KineticLaw

763776
constant: true
size: 1.0E-17
spatial dimensions: 3.0
type: Compartment

764416
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 763757
type: Species

830913
units: 344978
value: 5.0E-18
type: LocalParameter

357966
local parameters: 831244
notes: k3*PP1_minus_active_PSD_slash_PP1_sbo_27_sbc__slash_PP1_sbo_27_sbc__cplx
type: KineticLaw

830853
units: 345062
value: 2.77776E-19
type: LocalParameter

350760
stoichiometry: 1.0
species: 764416
type: SpeciesReference

831475
units: 344978
value: 7.2E-16
type: LocalParameter

346484
stoichiometry: 1.0
species: 764616
type: SpeciesReference

767036
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 763776
type: Species

354250
stoichiometry: 1.0
species: 766156
type: SpeciesReference

354672
local parameters: 830938
notes: k3*actCaMKII_minus_PSD_slash_CaMKII_sbo_13_sbc__slash_CaMKII_sbo_13_sbc__cplx
type: KineticLaw

767516
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 763757
type: Species

831043
units: 344978
value: 6.8E-18
type: LocalParameter

351651
stoichiometry: 1.0
species: 764656
type: SpeciesReference

351809
stoichiometry: 1.0
species: 764736
type: SpeciesReference

346871
stoichiometry: 1.0
species: 766336
type: SpeciesReference

831589
units: 345062
value: 2.011824E-17
type: LocalParameter

768676
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 763776
type: Species

353662
local parameters: 830847
local parameters: 830844
notes: k1*AMPAR_memb_slash_A_B*actCaMKII_minus_PSD-k2*actCaMKII_minus_PSD_slash_CaMKII_sbo_3_sbc__slash_CaMKII_sbo_3_sbc__cplx
type: KineticLaw

348634
stoichiometry: 1.0
species: 767356
type: SpeciesReference

357881
stoichiometry: 1.0
species: 768576
type: SpeciesReference

352817
stoichiometry: 1.0
species: 765536
type: SpeciesReference

767556
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 763757
type: Species

830346
units: 345062
value: 5.399946E-16
type: LocalParameter

774415
kinetic law: 356127
product: 356115
product: 356103
reactant: 356091
fast: false
reversible: false
type: Reaction

355048
stoichiometry: 1.0
species: 766376
type: SpeciesReference

350445
stoichiometry: 1.0
species: 764356
type: SpeciesReference

355826
stoichiometry: 1.0
species: 766376
type: SpeciesReference

772596
kinetic law: 351481
product: 351468
product: 351455
reactant: 351443
fast: false
reversible: false
type: Reaction

347701
stoichiometry: 1.0
species: 764636
type: SpeciesReference

776235
kinetic law: 360989
product: 360977
product: 360965
reactant: 360953
fast: false
reversible: false
type: Reaction

831196
units: 344978
value: 1.4E-17
type: LocalParameter

348367
local parameters: 830352
notes: k3*PKA_minus_active_slash_PKA_minus_phosph_minus_I1_slash_PKA_minus_phosph_minus_I1_cplx
type: KineticLaw

830679
units: 345062
value: 6.428808E-19
type: LocalParameter

359901
stoichiometry: 1.0
species: 767296
type: SpeciesReference

831427
units: 345062
value: 1.8106416E-16
type: LocalParameter

346219
local parameters: 830085
local parameters: 830082
notes: kf*PKA_minus_active*PKA_slash_PKA_minus_inhibitor-kb*PKA_slash_inhibited_minus_PKA
type: KineticLaw

765836
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 763776
type: Species

830850
units: 344978
value: 5.0E-18
type: LocalParameter

346726
stoichiometry: 1.0
species: 768956
type: SpeciesReference

357205
stoichiometry: 1.0
species: 768736
type: SpeciesReference

355983
local parameters: 831061
local parameters: 831058
notes: k1*AMPAR_memb_slash_A831_star_845_star__B*PP1_minus_active_PSD-k2*PP1_minus_active_PSD_slash_PP1_sbo_7_sbc__slash_PP1_sbo_7_sbc__cplx
type: KineticLaw

357013
stoichiometry: 1.0
species: 768756
type: SpeciesReference

831157
units: 345062
value: 8.7498E-18
type: LocalParameter

346087
stoichiometry: 1.0
species: 765356
type: SpeciesReference

356235
stoichiometry: 1.0
species: 768616
type: SpeciesReference

830394
units: 344978
value: 2.16E-15
type: LocalParameter

830244
units: 345062
value: 1.08E-19
type: LocalParameter

771416
kinetic law: 348610
product: 348598
reactant: 348586
reactant: 348574
fast: false
reversible: true
type: Reaction

766336
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 763776
type: Species

774375
kinetic law: 355935
product: 355923
product: 355911
reactant: 355898
fast: false
reversible: false
type: Reaction

349406
stoichiometry: 1.0
species: 767416
type: SpeciesReference

362754
stoichiometry: 1.0
species: 769456
type: SpeciesReference

361581
stoichiometry: 1.0
species: 768716
type: SpeciesReference

362429
stoichiometry: 1.0
species: 767636
type: SpeciesReference

830919
units: 344978
value: 2.0E-17
type: LocalParameter

356749
stoichiometry: 1.0
species: 766776
type: SpeciesReference

353058
stoichiometry: 1.0
species: 769096
type: SpeciesReference

831199
units: 344978
value: 3.5E-18
type: LocalParameter

345774
stoichiometry: 1.0
species: 765176
type: SpeciesReference

774416
kinetic law: 356175
product: 356163
reactant: 356151
reactant: 356139
fast: false
reversible: true
type: Reaction

830343
units: 344978
value: 8.1E-16
type: LocalParameter

831319
units: 345062
value: 1.020006E-18
type: LocalParameter

831424
units: 344978
value: 1.8E-16
type: LocalParameter

767456
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 763757
type: Species

360167
local parameters: 831448
local parameters: 831445
notes: k1*AMPAR_slash_A831_star__B831_star_845_star_*CaM_Ca_n_minus_CaNAB-k2*CaM_Ca_n_minus_CaNAB_slash_PP2B_sbo_24_sbc__slash_PP2B_sbo_24_sbc__cplx
type: KineticLaw

351115
stoichiometry: 1.0
species: 763956
type: SpeciesReference

356175
local parameters: 831079
local parameters: 831076
notes: k1*AMPAR_memb_slash_A831_star__B845_star_*PP1_minus_active_PSD-k2*PP1_minus_active_PSD_slash_PP1_sbo_9_sbc__slash_PP1_sbo_9_sbc__cplx
type: KineticLaw

771236
kinetic law: 348175
product: 348163
product: 348151
reactant: 348139
fast: false
reversible: false
type: Reaction

358098
stoichiometry: 1.0
species: 767056
type: SpeciesReference

358910
stoichiometry: 1.0
species: 767236
type: SpeciesReference

352208
local parameters: 830709
local parameters: 830706
notes: k1*PP1_PSD_slash_I1_star_*PP2A-k2*PP2A_slash_PP2A_minus_dephosph_minus_I1_PSD_slash_PP2A_minus_dephosph_minus_I1_PSD_cplx
type: KineticLaw

830241
units: 344978
value: 8.0E-20
type: LocalParameter

830397
units: 344978
value: 5.4E-16
type: LocalParameter

773496
kinetic law: 353662
product: 353650
reactant: 353638
reactant: 353626
fast: false
reversible: true
type: Reaction

359877
local parameters: 831421
local parameters: 831418
notes: k1*AMPAR_slash_A_B845_star_*CaM_Ca_n_minus_CaNAB-k2*CaM_Ca_n_minus_CaNAB_slash_PP2B_sbo_21_sbc__slash_PP2B_sbo_21_sbc__cplx
type: KineticLaw

831478
units: 344978
value: 1.8E-16
type: LocalParameter

352184
stoichiometry: 1.0
species: 765076
type: SpeciesReference

776175
kinetic law: 360843
product: 360831
reactant: 360819
reactant: 360807
fast: false
reversible: true
type: Reaction

349008
stoichiometry: 1.0
species: 764076
type: SpeciesReference

358886
stoichiometry: 1.0
species: 767236
type: SpeciesReference

357229
stoichiometry: 1.0
species: 766876
type: SpeciesReference

830304
units: 344978
value: 9.0E-16
type: LocalParameter

351127
stoichiometry: 1.0
species: 764496
type: SpeciesReference

830457
units: 344978
value: 2.16E-15
type: LocalParameter

362295
local parameters: 831646
local parameters: 831643
notes: k1*AMPAR_memb_slash_A835_star_845_star__B835_star_845_star_*CaM_Ca_n_minus_CaNAB-k2*CaM_Ca_n_minus_CaNAB_slash_PP2B_sbo_13_sbc__slash_PP2B_sbo_13_sbc__cplx
type: KineticLaw

345618
stoichiometry: 1.0
species: 764916
type: SpeciesReference

768636
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 763776
type: Species

359478
stoichiometry: 1.0
species: 767756
type: SpeciesReference

352756
stoichiometry: 1.0
species: 763916
type: SpeciesReference

831046
units: 344978
value: 1.7E-18
type: LocalParameter

347640
stoichiometry: 1.0
species: 768416
type: SpeciesReference

353154
stoichiometry: 1.0
species: 769096
type: SpeciesReference

765876
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 763776
type: Species

350907
stoichiometry: 1.0
species: 768676
type: SpeciesReference

359889
stoichiometry: 1.0
species: 767836
type: SpeciesReference

830673
units: 344978
value: 2.16E-15
type: LocalParameter

830520
units: 344978
value: 2.16E-15
type: LocalParameter

348827
stoichiometry: 1.0
species: 767576
type: SpeciesReference

830391
units: 345062
value: 3.5998992E-16
type: LocalParameter

361400
stoichiometry: 1.0
species: 767636
type: SpeciesReference

766556
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 763776
type: Species

357772
local parameters: 831226
notes: k3*PP1_minus_active_PSD_slash_PP1_sbo_25_sbc__slash_PP1_sbo_25_sbc__cplx
type: KineticLaw

776635
kinetic law: 361955
product: 361942
product: 361930
reactant: 361918
fast: false
reversible: false
type: Reaction

775835
kinetic law: 360021
product: 360009
product: 359997
reactant: 359985
fast: false
reversible: false
type: Reaction

362646
stoichiometry: 1.0
species: 765776
type: SpeciesReference

346195
stoichiometry: 1.0
species: 765416
type: SpeciesReference

766516
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 763776
type: Species

831202
units: 345062
value: 8.7498E-18
type: LocalParameter

354406
stoichiometry: 1.0
species: 769136
type: SpeciesReference

351918
local parameters: 830682
local parameters: 830679
notes: k1*CaMKII_slash_CaMKII_minus_CaM*CaMKII_slash_tot_autonomous_CaMKII-k2*CaMKII_slash_tot_autonomous_CaMKII_slash_auton_286_slash_auton_286_cplx
type: KineticLaw

345412
stoichiometry: 1.0
species: 764816
type: SpeciesReference

773016
kinetic law: 352499
product: 352487
reactant: 352475
reactant: 352463
notes: The rates here are so slow I do not know if we should even bother with this enz reacn. These numbers are from Liu and Storm. Other refs suggest that the Km stays the same but the Vmax goes to 10% of the CaM stim levels. Prev: k1=2.2e-9, k2 = 0.0052, k3 = 0.0013 New : k1=5.7e-8, k2=.136, k3=.034
fast: false
reversible: true
type: Reaction

359199
local parameters: 831358
local parameters: 831355
notes: k1*PP1_slash_PP1_minus_I1_star_*CaM_Ca_n_minus_CaNAB-k2*CaM_Ca_n_minus_CaNAB_slash_dephosph_minus_PP1_minus_I_star__slash_dephosph_minus_PP1_minus_I_star__cplx
type: KineticLaw

768496
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 763776
type: Species

767856
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 763757
type: Species

764676
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 763757
type: Species

775255
kinetic law: 358593
product: 358580
reactant: 358568
reactant: 358556
notes: Rates are 60% those of PKC-phosph-neurogranin. See Huang et al ABB 305:2 570-580 1993
fast: false
reversible: true
type: Reaction

345846
stoichiometry: 1.0
species: 763796
type: SpeciesReference

831088
units: 344978
value: 1.4E-17
type: LocalParameter

362101
local parameters: 831628
local parameters: 831625
notes: k1*AMPAR_memb_slash_A845_star__B831_star_*CaM_Ca_n_minus_CaNAB-k2*CaM_Ca_n_minus_CaNAB_slash_PP2B_sbo_11_sbc__slash_PP2B_sbo_11_sbc__cplx
type: KineticLaw

347857
stoichiometry: 1.0
species: 764596
type: SpeciesReference

350651
local parameters: 830565
local parameters: 830562
notes: k1*AMPAR_memb_slash_A831_star__B*PKA_minus_active-k2*PKA_minus_active_slash_PKA_sbo_6_sbc__slash_PKA_sbo_6_sbc__cplx
type: KineticLaw

348259
stoichiometry: 1.0
species: 763956
type: SpeciesReference

356394
stoichiometry: 1.0
species: 768516
type: SpeciesReference

353554
stoichiometry: 1.0
species: 766016
type: SpeciesReference

345026
exponent: 3.0
scale: 0
multipler: 1.0
kind: LITRE
type: SBMLUnit

361472
local parameters: 831568
notes: k3*CaM_Ca_n_minus_CaNAB_slash_PP2B_sbo_4_sbc__slash_PP2B_sbo_4_sbc__cplx
type: KineticLaw

349515
stoichiometry: 1.0
species: 763956
type: SpeciesReference

770556
kinetic law: 346666
product: 346653
product: 346640
reactant: 346628
notes: Same as for back_1
fast: false
reversible: true
type: Reaction

830301
units: 345062
value: 2.2062942E-16
type: LocalParameter

830634
units: 345062
value: 3.999888E-17
type: LocalParameter

830959
units: 345062
value: 4.99998E-18
type: LocalParameter

356857
local parameters: 831142
local parameters: 831139
notes: k1*AMPAR_memb_slash_A835_star_845_star__B835_star_845_star_*PP1_minus_active_PSD-k2*PP1_minus_active_PSD_slash_PP1_sbo_16_sbc__slash_PP1_sbo_16_sbc__cplx
type: KineticLaw

347219
stoichiometry: 1.0
species: 768896
type: SpeciesReference

831628
units: 344978
value: 7.2E-16
type: LocalParameter

776535
kinetic law: 361714
product: 361702
reactant: 361689
reactant: 361677
fast: false
reversible: true
type: Reaction

774715
kinetic law: 357290
product: 357278
product: 357266
reactant: 357253
fast: false
reversible: false
type: Reaction

348562
local parameters: 830370
notes: k3*PKA_minus_active_slash_PKA_sbo_17_sbc__slash_PKA_sbo_17_sbc__cplx
type: KineticLaw

776575
kinetic law: 361810
product: 361798
reactant: 361786
reactant: 361774
fast: false
reversible: true
type: Reaction

771136
kinetic law: 347931
product: 347919
reactant: 347906
reactant: 347893
fast: false
reversible: true
type: Reaction

831367
units: 344978
value: 1.224E-16
type: LocalParameter

360662
stoichiometry: 1.0
species: 767996
type: SpeciesReference

830748
units: 344978
value: 1.8E-16
type: LocalParameter

775875
kinetic law: 360119
product: 360107
product: 360095
reactant: 360083
fast: false
reversible: false
type: Reaction

353264
stoichiometry: 1.0
species: 765876
type: SpeciesReference

764636
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 763757
type: Species

774376
kinetic law: 355983
product: 355971
reactant: 355959
reactant: 355947
fast: false
reversible: true
type: Reaction

770496
kinetic law: 346520
product: 346508
reactant: 346496
reactant: 346484
notes: Rates to match curve in fig2 from Shen and Meyer, Science 284:162-166(1999), calculated for 6:1 alpha:beta CaMKII heterodimers
fast: false
reversible: true
type: Reaction

362537
local parameters: 831667
notes: k3*CaM_Ca_n_minus_CaNAB_slash_PP2B_sbo_15_sbc__slash_PP2B_sbo_15_sbc__cplx
type: KineticLaw

354346
stoichiometry: 1.0
species: 766176
type: SpeciesReference

356929
stoichiometry: 1.0
species: 766376
type: SpeciesReference

831154
units: 344978
value: 1.7E-18
type: LocalParameter

361702
stoichiometry: 1.0
species: 768216
type: SpeciesReference

831049
units: 345062
value: 8.7498E-18
type: LocalParameter

830637
units: 344978
value: 2.16E-15
type: LocalParameter

357169
stoichiometry: 1.0
species: 768576
type: SpeciesReference

348451
stoichiometry: 1.0
species: 763956
type: SpeciesReference

775035
kinetic law: 358062
product: 358050
product: 358038
reactant: 358026
fast: false
reversible: false
type: Reaction

831205
units: 344978
value: 1.4E-17
type: LocalParameter

360058
stoichiometry: 1.0
species: 767876
type: SpeciesReference

830676
units: 344978
value: 5.4E-16
type: LocalParameter

767896
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 763757
type: Species

830523
units: 344978
value: 5.4E-16
type: LocalParameter

763956
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 763757
type: Species

350555
local parameters: 830556
local parameters: 830553
notes: k1*AMPAR_memb_slash_A831_star_845_star__B*PKA_minus_active-k2*PKA_minus_active_slash_PKA_sbo_5_sbc__slash_PKA_sbo_5_sbc__cplx
type: KineticLaw

356420
local parameters: 831100
notes: k3*PP1_minus_active_PSD_slash_PP1_sbo_11_sbc__slash_PP1_sbo_11_sbc__cplx
type: KineticLaw

352487
stoichiometry: 1.0
species: 765216
type: SpeciesReference

347797
stoichiometry: 1.0
species: 764676
type: SpeciesReference

346544
stoichiometry: 1.0
species: 767616
type: SpeciesReference

349226
stoichiometry: 1.0
species: 763956
type: SpeciesReference

774795
kinetic law: 357482
product: 357470
product: 357458
reactant: 357446
fast: false
reversible: false
type: Reaction

352535
stoichiometry: 1.0
species: 765176
type: SpeciesReference

774815
kinetic law: 357530
product: 357518
reactant: 357506
reactant: 357494
fast: false
reversible: true
type: Reaction

354142
local parameters: 830892
local parameters: 830889
notes: k1*AMPAR_memb_slash_A845_star__B831_star_845_star_*actCaMKII_minus_PSD-k2*actCaMKII_minus_PSD_slash_CaMKII_sbo_8_sbc__slash_CaMKII_sbo_8_sbc__cplx
type: KineticLaw

347147
stoichiometry: 1.0
species: 768436
type: SpeciesReference

769376
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 763776
type: Species

763996
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 763757
type: Species

347931
local parameters: 830313
local parameters: 830310
notes: k1*CaMKII_slash_CaMKII_star__star__star_*PP1_minus_active-k2*PP1_minus_active_slash_Deph_minus_thr305_slash_Deph_minus_thr305_cplx
type: KineticLaw

359587
local parameters: 831394
local parameters: 831391
notes: k1*AMPAR_slash_A831_star_845_star__B*CaM_Ca_n_minus_CaNAB-k2*CaM_Ca_n_minus_CaNAB_slash_PP2B_sbo_18_sbc__slash_PP2B_sbo_18_sbc__cplx
type: KineticLaw

347183
stoichiometry: 1.0
species: 768896
type: SpeciesReference

357808
stoichiometry: 1.0
species: 766996
type: SpeciesReference

357061
stoichiometry: 1.0
species: 766836
type: SpeciesReference

770456
kinetic law: 346423
product: 346411
reactant: 346399
notes: Represents diffusion, from a volume of 9e-20 to 5e-18. Assuming neck dimensions of 0.1 x 0.1 microns, this works out to a diffusion const of about 270 um^2/sec, which is pretty conservative. It is what cAMP does in frog cilia.
fast: false
reversible: true
type: Reaction

831316
units: 344978
value: 3.6E-16
type: LocalParameter

350230
stoichiometry: 1.0
species: 763956
type: SpeciesReference

775755
kinetic law: 359829
product: 359817
product: 359805
reactant: 359793
fast: false
reversible: false
type: Reaction

352293
stoichiometry: 1.0
species: 765156
type: SpeciesReference

830097
units: 344978
value: 0.0
type: LocalParameter

830010
units: 345062
value: 3.0E-18
type: LocalParameter

830499
units: 345062
value: 3.5998992E-16
type: LocalParameter

830052
units: 345062
value: 4.86E-15
type: LocalParameter

360771
stoichiometry: 1.0
species: 767356
type: SpeciesReference

773236
kinetic law: 353034
product: 353022
product: 353010
reactant: 352998
fast: false
reversible: false
type: Reaction

347749
stoichiometry: 1.0
species: 763816
type: SpeciesReference

356067
stoichiometry: 1.0
species: 766636
type: SpeciesReference

360626
stoichiometry: 1.0
species: 767636
type: SpeciesReference

349117
stoichiometry: 1.0
species: 767476
type: SpeciesReference

355509
stoichiometry: 1.0
species: 766516
type: SpeciesReference

361218
stoichiometry: 1.0
species: 768116
type: SpeciesReference

361110
stoichiometry: 1.0
species: 767636
type: SpeciesReference

345557
local parameters: 830001
local parameters: 829998
notes: kf*CaM_minus_TR2_minus_Ca2_minus_PSD*Ca_minus_PSD-kb*CaM_minus_Ca3_minus_PSD
type: KineticLaw

830124
units: 345062
value: 1.08E-20
type: LocalParameter

830956
units: 344978
value: 5.0E-18
type: LocalParameter

831625
units: 345062
value: 2.011824E-17
type: LocalParameter

351065
stoichiometry: 1.0
species: 768736
type: SpeciesReference

773636
kinetic law: 353998
product: 353986
product: 353974
reactant: 353962
fast: false
reversible: false
type: Reaction

770896
kinetic law: 347399
product: 347387
reactant: 347375
reactant: 347363
fast: false
reversible: true
type: Reaction

770856
kinetic law: 347303
product: 347291
reactant: 347279
fast: false
reversible: true
type: Reaction

357699
stoichiometry: 1.0
species: 766376
type: SpeciesReference

349831
stoichiometry: 1.0
species: 767536
type: SpeciesReference

831313
units: 344978
value: 1.44E-15
type: LocalParameter

359042
stoichiometry: 1.0
species: 767636
type: SpeciesReference

351505
stoichiometry: 1.0
species: 763956
type: SpeciesReference

830670
units: 345062
value: 7.714278E-18
type: LocalParameter

767936
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 763757
type: Species

766996
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 763776
type: Species

772196
kinetic law: 350507
product: 350495
product: 350483
reactant: 350471
fast: false
reversible: false
type: Reaction

360589
stoichiometry: 1.0
species: 767636
type: SpeciesReference

349274
stoichiometry: 1.0
species: 764136
type: SpeciesReference

830526
units: 345062
value: 3.999888E-17
type: LocalParameter

354491
stoichiometry: 1.0
species: 768776
type: SpeciesReference

361557
stoichiometry: 1.0
species: 767636
type: SpeciesReference

354298
stoichiometry: 1.0
species: 768676
type: SpeciesReference

351382
local parameters: 830631
notes: k3*PKA_minus_active_slash_PKA_sbo_13_sbc__slash_PKA_sbo_13_sbc__cplx
type: KineticLaw

348040
stoichiometry: 1.0
species: 763876
type: SpeciesReference

769996
kinetic law: 345375
product: 345363
reactant: 345351
reactant: 345339
notes: K3 = 21.5, K4 = 2.8. Assuming that the K4 step happens first, we get kb/kf = 2.8 uM = 1.68e6 so kf =6e-6 assuming kb = 10
fast: false
reversible: true
type: Reaction

352890
local parameters: 830775
local parameters: 830772
notes: k1*cAMP*AC_slash_PDE1-k2*AC_slash_PDE1_slash_PDE1_slash_PDE1_cplx
type: KineticLaw

359503
stoichiometry: 1.0
species: 767756
type: SpeciesReference

831310
units: 345062
value: 5.399946E-17
type: LocalParameter

346592
stoichiometry: 1.0
species: 764596
type: SpeciesReference

357736
stoichiometry: 1.0
species: 766976
type: SpeciesReference

347689
local parameters: 830289
local parameters: 830286
notes: kf*AMPAR_bulk-kb*AMPAR_slash_A_B
type: KineticLaw

830910
units: 344978
value: 2.0E-17
type: LocalParameter

771936
kinetic law: 349867
product: 349855
reactant: 349843
reactant: 349831
fast: false
reversible: true
type: Reaction

347809
stoichiometry: 1.0
species: 763797
type: SpeciesReference

776855
kinetic law: 362489
product: 362477
reactant: 362465
reactant: 362453
fast: false
reversible: true
type: Reaction

830127
units: 344978
value: 0.0
type: LocalParameter

362862
stoichiometry: 1.0
species: 768496
type: SpeciesReference

358424
stoichiometry: 1.0
species: 765796
type: SpeciesReference

348415
local parameters: 830358
local parameters: 830355
notes: k1*PP1_PSD_slash_I1*PKA_minus_active-k2*PKA_minus_active_slash_PKA_minus_phosph_minus_I1_PSD_slash_PKA_minus_phosph_minus_I1_PSD_cplx
type: KineticLaw

346508
stoichiometry: 1.0
species: 765756
type: SpeciesReference

356319
local parameters: 831091
notes: k3*PP1_minus_active_PSD_slash_PP1_sbo_10_sbc__slash_PP1_sbo_10_sbc__cplx
type: KineticLaw

345175
local parameters: 829953
local parameters: 829950
notes: kf*PP1_slash_I1_star_*PP1_minus_active-kb*PP1_slash_PP1_minus_I1_star_
type: KineticLaw

830013
units: 344978
value: 1.0E-17
type: LocalParameter

776395
kinetic law: 361375
product: 361363
product: 361351
reactant: 361339
fast: false
reversible: false
type: Reaction

354721
local parameters: 830944
local parameters: 830941
notes: k1*AMPAR_memb_slash_A831_star_845_star__B*actCaMKII_minus_PSD-k2*actCaMKII_minus_PSD_slash_CaMKII_sbo_14_sbc__slash_CaMKII_sbo_14_sbc__cplx
type: KineticLaw

358412
stoichiometry: 1.0
species: 767116
type: SpeciesReference

831364
units: 345062
value: 3.420036E-18
type: LocalParameter

349382
local parameters: 830448
local parameters: 830445
notes: k1*AMPAR_slash_A831_star__B845_star_*PKA_minus_active-k2*PKA_minus_active_slash_PKA_sbo_25_sbc__slash_PKA_sbo_25_sbc__cplx
type: KineticLaw

770216
kinetic law: 345882
product: 345870
reactant: 345858
reactant: 345846
fast: false
reversible: true
type: Reaction

352028
stoichiometry: 1.0
species: 765096
type: SpeciesReference

355194
stoichiometry: 1.0
species: 766456
type: SpeciesReference

775215
kinetic law: 358496
product: 358484
reactant: 358472
reactant: 358460
notes: Rates from Huang et al ABB 305:2 570-580 1993
fast: false
reversible: true
type: Reaction

346327
stoichiometry: 1.0
species: 765556
type: SpeciesReference

350591
stoichiometry: 1.0
species: 763956
type: SpeciesReference

770976
kinetic law: 347579
product: 347567
reactant: 347555
fast: false
reversible: true
type: Reaction

764336
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 763757
type: Species

347075
stoichiometry: 1.0
species: 768536
type: SpeciesReference

358014
local parameters: 831250
local parameters: 831247
notes: k1*AMPAR_memb_slash_A835_star_845_star__B835_star_845_star_*PP1_minus_active_PSD-k2*PP1_minus_active_PSD_slash_PP1_sbo_28_sbc__slash_PP1_sbo_28_sbc__cplx
type: KineticLaw

360601
local parameters: 831487
notes: k3*CaM_Ca_n_minus_CaNAB_slash_PP2B_sbo_28_sbc__slash_PP2B_sbo_28_sbc__cplx
type: KineticLaw

346653
stoichiometry: 1.0
species: 767616
type: SpeciesReference

831151
units: 344978
value: 6.8E-18
type: LocalParameter

356701
stoichiometry: 1.0
species: 766376
type: SpeciesReference

766916
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 763776
type: Species

352427
stoichiometry: 1.0
species: 764996
type: SpeciesReference

358351
local parameters: 831280
notes: k3*PP1_minus_active_PSD_slash_PP1_sbo_31_sbc__slash_PP1_sbo_31_sbc__cplx
type: KineticLaw

773816
kinetic law: 354430
product: 354418
reactant: 354406
reactant: 354394
fast: false
reversible: true
type: Reaction

361097
stoichiometry: 1.0
species: 768696
type: SpeciesReference

358958
local parameters: 831334
notes: k3*PKC_minus_active_slash_PKC_minus_phosph_minus_ng_minus_CaM_PSD_slash_PKC_minus_phosph_minus_ng_minus_CaM_PSD_cplx
type: KineticLaw

772996
kinetic law: 352451
product: 352439
product: 352427
reactant: 352414
fast: false
reversible: false
type: Reaction

830953
units: 344978
value: 2.0E-17
type: LocalParameter

772156
kinetic law: 350406
product: 350393
product: 350380
reactant: 350367
fast: false
reversible: false
type: Reaction

771976
kinetic law: 349963
product: 349951
reactant: 349939
reactant: 349927
fast: false
reversible: true
type: Reaction

345136
stoichiometry: 1.0
species: 765016
type: SpeciesReference

352377
stoichiometry: 1.0
species: 765176
type: SpeciesReference

355766
stoichiometry: 1.0
species: 766376
type: SpeciesReference

830631
units: 344978
value: 5.4E-16
type: LocalParameter

831208
units: 344978
value: 3.5E-18
type: LocalParameter

358291
stoichiometry: 1.0
species: 767096
type: SpeciesReference

831622
units: 344978
value: 1.8E-16
type: LocalParameter

354455
stoichiometry: 1.0
species: 768576
type: SpeciesReference

830754
units: 345062
value: 2.2680162E-16
type: LocalParameter

349599
stoichiometry: 1.0
species: 767456
type: SpeciesReference

765336
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 763757
type: Species

350024
stoichiometry: 1.0
species: 768656
type: SpeciesReference

353758
local parameters: 830856
local parameters: 830853
notes: k1*AMPAR_memb_slash_A845_star__B845_star_*actCaMKII_minus_PSD-k2*actCaMKII_minus_PSD_slash_CaMKII_sbo_4_sbc__slash_CaMKII_sbo_4_sbc__cplx
type: KineticLaw

360516
stoichiometry: 1.0
species: 767456
type: SpeciesReference

358327
stoichiometry: 1.0
species: 768536
type: SpeciesReference

830292
units: 345062
value: 2.2062942E-16
type: LocalParameter

351822
local parameters: 830673
local parameters: 830670
notes: k1*CaMKII_slash_CaMKII_minus_thr286*CaMKII_slash_tot_autonomous_CaMKII-k2*CaMKII_slash_tot_autonomous_CaMKII_slash_auton_305_slash_auton_305_cplx
type: KineticLaw

765256
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 763757
type: Species

356761
local parameters: 831133
local parameters: 831130
notes: k1*AMPAR_memb_slash_A845_star__B831_star_*PP1_minus_active_PSD-k2*PP1_minus_active_PSD_slash_PP1_sbo_15_sbc__slash_PP1_sbo_15_sbc__cplx
type: KineticLaw

357602
stoichiometry: 1.0
species: 766376
type: SpeciesReference

830712
units: 344978
value: 1.8E-16
type: LocalParameter

830148
units: 345062
value: 1.00002E-14
type: LocalParameter

360698
local parameters: 831496
notes: k3*CaM_Ca_n_minus_CaNAB_slash_PP2B_sbo_29_sbc__slash_PP2B_sbo_29_sbc__cplx
type: KineticLaw

771796
kinetic law: 349527
product: 349515
product: 349503
reactant: 349490
fast: false
reversible: false
type: Reaction

360252
stoichiometry: 1.0
species: 767916
type: SpeciesReference

346411
stoichiometry: 1.0
species: 765716
type: SpeciesReference

770236
kinetic law: 345931
product: 345919
reactant: 345907
reactant: 345895
notes: Hasler et al FASEB J 6:2734-2741 1992 say Kd =1e-7M for type II, 5.6e-8 M for type I. Take mean which comes to 2e-13 #/cell Smith et al PNAS USA 78:3 1591-1595 1981 have better data. First kf/kb=2.1e7/M = 3.5e-5 (#/cell). Ogreid and Doskeland Febs Lett 129:2 287-292 1981 have figs suggesting time course of complete assoc is < 1 min.
fast: false
reversible: true
type: Reaction

354551
stoichiometry: 1.0
species: 768816
type: SpeciesReference

773196
kinetic law: 352938
product: 352926
product: 352914
reactant: 352902
fast: false
reversible: false
type: Reaction

346750
local parameters: 830157
local parameters: 830154
notes: kf*Ca_control_cyt-kb*Ca
type: KineticLaw

356545
stoichiometry: 1.0
species: 766376
type: SpeciesReference

352064
local parameters: 830694
notes: k3*PP2A_slash_PP2A_minus_dephosph_minus_I1_slash_PP2A_minus_dephosph_minus_I1_cplx
type: KineticLaw

831094
units: 345062
value: 8.7498E-18
type: LocalParameter

775535
kinetic law: 359295
product: 359283
reactant: 359271
reactant: 359259
fast: false
reversible: true
type: Reaction

771076
kinetic law: 347785
product: 347773
product: 347761
reactant: 347749
fast: false
reversible: false
type: Reaction

830793
units: 344978
value: 2.4E-16
type: LocalParameter

829995
units: 344978
value: 7.2E-16
type: LocalParameter

353082
local parameters: 830793
local parameters: 830790
notes: k1*CaMKII_minus_thr286_minus_PSD*tot_minus_auto_minus_PSD-k2*tot_minus_auto_minus_PSD_slash_auton_minus_305_minus_PSD_slash_auton_minus_305_minus_PSD_cplx
type: KineticLaw

764596
constant: false
boundary condition: false
has only substance units: false
initial concentration: 20.0
initial amount: NaN
in compartment: 763757
type: Species

358472
stoichiometry: 1.0
species: 767136
type: SpeciesReference

829956
units: 345062
value: 4.4999712E-15
type: LocalParameter

350943
local parameters: 830592
local parameters: 830589
notes: k1*AMPAR_memb_slash_A845_star__B831_star_*PKA_minus_active-k2*PKA_minus_active_slash_PKA_sbo_9_sbc__slash_PKA_sbo_9_sbc__cplx
type: KineticLaw

830187
units: 344978
value: 1.26E-19
type: LocalParameter

352780
stoichiometry: 1.0
species: 765616
type: SpeciesReference

349746
stoichiometry: 1.0
species: 763956
type: SpeciesReference

351187
local parameters: 830613
notes: k3*PKA_minus_active_slash_PKA_sbo_11_sbc__slash_PKA_sbo_11_sbc__cplx
type: KineticLaw

773116
kinetic law: 352744
product: 352731
product: 352719
reactant: 352706
fast: false
reversible: false
type: Reaction

831139
units: 345062
value: 8.7498E-18
type: LocalParameter

764556
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 763757
type: Species

361267
stoichiometry: 1.0
species: 767636
type: SpeciesReference

767496
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 763757
type: Species

353325
local parameters: 830814
notes: k3*tot_minus_auto_minus_PSD_slash_auton_minus_autoph_slash_auton_minus_autoph_cplx
type: KineticLaw

345448
stoichiometry: 1.0
species: 764856
type: SpeciesReference

362307
stoichiometry: 1.0
species: 768336
type: SpeciesReference

830691
units: 344978
value: 7.50006E-16
type: LocalParameter

775575
kinetic law: 359392
product: 359379
reactant: 359367
reactant: 359355
fast: false
reversible: true
type: Reaction

830826
units: 345062
value: 2.77776E-19
type: LocalParameter

830145
units: 345062
value: 5.4E-21
type: LocalParameter

769936
kinetic law: 345227
product: 345214
reactant: 345201
reactant: 345188
notes: This is tricky. There is some cooperativity here arising from interactions between the subunits of the CAMKII holoenzyme. However, the stoichiometry is 1. Kb/Kf = 6e4 #/cell. Rate is fast (see Hanson et al Neuron 12 943-956 1994) so lets say kb = 10. This gives kf = 1.6667e-4 H&S AnnRev Biochem 92 give tau for dissoc as 0.2 sec at low Ca, 0.4 at high. Low Ca = 100 nM = physiol.
fast: false
reversible: true
type: Reaction

356653
stoichiometry: 1.0
species: 766756
type: SpeciesReference

768276
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 763757
type: Species

346243
stoichiometry: 1.0
species: 765476
type: SpeciesReference

831091
units: 344978
value: 3.5E-18
type: LocalParameter

830790
units: 345062
value: 6.0E-19
type: LocalParameter

351627
local parameters: 830655
local parameters: 830652
notes: k1*CaMKII_slash_CaMKII_minus_thr286*CaMKII_slash_tot_CaM_CaMKII-k2*CaMKII_slash_tot_CaM_CaMKII_slash_CaM_act_305_slash_CaM_act_305_cplx
type: KineticLaw

769976
kinetic law: 345327
product: 345315
reactant: 345303
reactant: 345291
notes: Lets use the fast rate consts here. Since the rates are so different, I am not sure whether the order is relevant. These correspond to the TR2C fragment. We use the Martin et al rates here, plus the Drabicowski binding consts. All are scaled by 3X to cell temp. kf = 2e-10 kb = 72 Stemmer & Klee: K1=.9, K2=1.1. Assume 1.0uM for both. kb/kf=3.6e11. If kb=72, kf = 2e-10 (Exactly the same !)....
fast: false
reversible: true
type: Reaction

360710
stoichiometry: 1.0
species: 767416
type: SpeciesReference

353482
stoichiometry: 1.0
species: 765996
type: SpeciesReference

773936
kinetic law: 354721
product: 354709
reactant: 354697
reactant: 354684
fast: false
reversible: true
type: Reaction

771856
kinetic law: 349672
product: 349660
reactant: 349648
reactant: 349636
fast: false
reversible: true
type: Reaction

347351
local parameters: 830241
local parameters: 830238
notes: kf*AMPAR_slash_A835_star_845_star__B835_star_845_star_*Anchor-kb*AMPAR_memb_slash_A835_star_845_star__B835_star_845_star_
type: KineticLaw

359355
stoichiometry: 1.0
species: 766336
type: SpeciesReference

349783
stoichiometry: 1.0
species: 764216
type: SpeciesReference

830184
units: 344978
value: 3.5E-21
type: LocalParameter

829953
units: 344978
value: 9.0E-18
type: LocalParameter

351493
stoichiometry: 1.0
species: 768576
type: SpeciesReference

830751
units: 344942
value: 300.001920012288
type: LocalParameter

355449
local parameters: 831010
notes: k3*PP1_minus_active_PSD_slash_PP1_sbo_1_sbc__slash_PP1_sbo_1_sbc__cplx
type: KineticLaw

353602
stoichiometry: 1.0
species: 769136
type: SpeciesReference

361689
stoichiometry: 1.0
species: 767636
type: SpeciesReference

830601
units: 344978
value: 2.16E-15
type: LocalParameter

831511
units: 344978
value: 7.2E-16
type: LocalParameter

361822
stoichiometry: 1.0
species: 768236
type: SpeciesReference

773616
kinetic law: 353950
product: 353938
reactant: 353926
reactant: 353914
fast: false
reversible: true
type: Reaction

771816
kinetic law: 349575
product: 349563
reactant: 349551
reactant: 349539
fast: false
reversible: true
type: Reaction

347627
stoichiometry: 1.0
species: 768996
type: SpeciesReference

362234
stoichiometry: 1.0
species: 767636
type: SpeciesReference

831136
units: 344978
value: 1.7E-18
type: LocalParameter

764516
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 763757
type: Species

768236
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 763757
type: Species

767996
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 763757
type: Species

360071
local parameters: 831439
local parameters: 831436
notes: k1*AMPAR_slash_A_B831_star_845_star_*CaM_Ca_n_minus_CaNAB-k2*CaM_Ca_n_minus_CaNAB_slash_PP2B_sbo_23_sbc__slash_PP2B_sbo_23_sbc__cplx
type: KineticLaw

767956
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 763757
type: Species

767216
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 763757
type: Species

830418
units: 345062
value: 3.5998992E-16
type: LocalParameter

354612
stoichiometry: 1.0
species: 766236
type: SpeciesReference

357386
local parameters: 831190
notes: k3*PP1_minus_active_PSD_slash_PP1_sbo_21_sbc__slash_PP1_sbo_21_sbc__cplx
type: KineticLaw

770436
kinetic law: 346387
product: 346375
reactant: 346363
reactant: 346351
notes: For olf epi PDE1, affinity is 7 nM. Assume same for brain. Reaction should be pretty fast. Assume kb = 5/sec. Then kf = 5 / (0.007 * 6e5) = 1.2e-3
fast: false
reversible: true
type: Reaction

355633
stoichiometry: 1.0
species: 766376
type: SpeciesReference

352572
stoichiometry: 1.0
species: 763916
type: SpeciesReference

345339
stoichiometry: 1.0
species: 764976
type: SpeciesReference

830796
units: 344978
value: 6.0E-17
type: LocalParameter

362561
stoichiometry: 1.0
species: 767636
type: SpeciesReference

830820
units: 344978
value: 2.0E-17
type: LocalParameter

345253
stoichiometry: 1.0
species: 763796
type: SpeciesReference

348899
local parameters: 830403
local parameters: 830400
notes: k1*AMPAR_slash_A_B*PKA_minus_active-k2*PKA_minus_active_slash_PKA_sbo_20_sbc__slash_PKA_sbo_20_sbc__cplx
type: KineticLaw

831097
units: 344978
value: 1.4E-17
type: LocalParameter

358219
stoichiometry: 1.0
species: 767076
type: SpeciesReference

360553
local parameters: 831484
local parameters: 831481
notes: k1*AMPAR_slash_A835_star_845_star__B835_star_845_star_*CaM_Ca_n_minus_CaNAB-k2*CaM_Ca_n_minus_CaNAB_slash_PP2B_sbo_28_sbc__slash_PP2B_sbo_28_sbc__cplx
type: KineticLaw

772496
kinetic law: 351235
product: 351223
reactant: 351211
reactant: 351199
fast: false
reversible: true
type: Reaction

355485
stoichiometry: 1.0
species: 766516
type: SpeciesReference

829959
units: 344978
value: 4.5E-16
type: LocalParameter

776995
kinetic law: 362826
product: 362814
product: 362802
reactant: 362790
fast: false
reversible: false
type: Reaction

774835
kinetic law: 357578
product: 357566
product: 357554
reactant: 357542
fast: false
reversible: false
type: Reaction

353590
stoichiometry: 1.0
species: 768616
type: SpeciesReference

360408
local parameters: 831469
notes: k3*CaM_Ca_n_minus_CaNAB_slash_PP2B_sbo_26_sbc__slash_PP2B_sbo_26_sbc__cplx
type: KineticLaw

769036
constant: false
boundary condition: true
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 763757
type: Species

351297
stoichiometry: 1.0
species: 768636
type: SpeciesReference

352136
stoichiometry: 1.0
species: 765056
type: SpeciesReference

830082
units: 345062
value: 5.399946E-15
type: LocalParameter

358580
stoichiometry: 1.0
species: 767176
type: SpeciesReference

359635
local parameters: 831397
notes: k3*CaM_Ca_n_minus_CaNAB_slash_PP2B_sbo_18_sbc__slash_PP2B_sbo_18_sbc__cplx
type: KineticLaw

830295
units: 344978
value: 9.0E-16
type: LocalParameter

830142
units: 344978
value: 3.0E-18
type: LocalParameter

348027
local parameters: 830322
local parameters: 830319
notes: k1*CaMKII_slash_CaMKII_star__star__star_*PP1_minus_active-k2*PP1_minus_active_slash_Deph_minus_thr286c_slash_Deph_minus_thr286c_cplx
type: KineticLaw

831619
units: 344978
value: 7.2E-16
type: LocalParameter

830202
units: 344978
value: 8.0E-21
type: LocalParameter

830757
units: 344978
value: 3.6E-15
type: LocalParameter

831349
units: 344978
value: 1.224E-16
type: LocalParameter

349867
local parameters: 830493
local parameters: 830490
notes: k1*AMPAR_slash_A845_star__B831_star_*PKA_minus_active-k2*PKA_minus_active_slash_PKA_sbo_30_sbc__slash_PKA_sbo_30_sbc__cplx
type: KineticLaw

830412
units: 344978
value: 2.16E-15
type: LocalParameter

345521
stoichiometry: 1.0
species: 765896
type: SpeciesReference

350133
stoichiometry: 1.0
species: 763956
type: SpeciesReference

830715
units: 345062
value: 6.4584E-18
type: LocalParameter

348077
local parameters: 830325
notes: k3*PP1_minus_active_slash_Deph_minus_thr286c_slash_Deph_minus_thr286c_cplx
type: KineticLaw

353866
stoichiometry: 1.0
species: 766076
type: SpeciesReference

361146
stoichiometry: 1.0
species: 768096
type: SpeciesReference

349442
stoichiometry: 1.0
species: 767476
type: SpeciesReference

354503
stoichiometry: 1.0
species: 769136
type: SpeciesReference

349068
stoichiometry: 1.0
species: 763956
type: SpeciesReference

764876
constant: false
boundary condition: false
has only substance units: false
initial concentration: 26.3333333333333
initial amount: NaN
in compartment: 763776
type: Species

346135
stoichiometry: 1.0
species: 765376
type: SpeciesReference

831133
units: 344978
value: 6.8E-18
type: LocalParameter

347243
stoichiometry: 1.0
species: 767416
type: SpeciesReference

772416
kinetic law: 351040
product: 351028
reactant: 351015
reactant: 351003
fast: false
reversible: true
type: Reaction

829998
units: 345062
value: 3.6E-17
type: LocalParameter

348935
stoichiometry: 1.0
species: 763956
type: SpeciesReference

830415
units: 344978
value: 5.4E-16
type: LocalParameter

350627
stoichiometry: 1.0
species: 763956
type: SpeciesReference

830718
units: 344978
value: 7.50006E-16
type: LocalParameter

354214
stoichiometry: 1.0
species: 769136
type: SpeciesReference

353227
local parameters: 830805
notes: k3*tot_minus_auto_minus_PSD_slash_auton_minus_286_minus_PSD_slash_auton_minus_286_minus_PSD_cplx
type: KineticLaw

361798
stoichiometry: 1.0
species: 768236
type: SpeciesReference

772896
kinetic law: 352208
product: 352196
reactant: 352184
reactant: 352172
notes: PP2A does most of the dephosph of I1 at basal Ca levels. See the review by Cohen in Ann Rev Biochem 1989. For now, lets halve Km. k1 was 3.3e-6, now 6.6e-6
fast: false
reversible: true
type: Reaction

770256
kinetic law: 345979
product: 345967
reactant: 345955
reactant: 345943
notes: For now let us set this to the same Km (1e-7M) as site B. This gives kf/kb = .7e-7M * 1e6 / (6e5^2) : 1/(6e5^2) = 2e-13:2.77e-12 Smith et al have better values. They say that this is cooperative, so the consts are now kf/kb =8.3e-4
fast: false
reversible: true
type: Reaction

775695
kinetic law: 359683
product: 359671
reactant: 359659
reactant: 359647
fast: false
reversible: true
type: Reaction

352926
stoichiometry: 1.0
species: 765636
type: SpeciesReference

357278
stoichiometry: 1.0
species: 766376
type: SpeciesReference

347881
local parameters: 830307
notes: k3*PP1_minus_active_slash_Deph_minus_thr286b_slash_Deph_minus_thr286b_cplx
type: KineticLaw

352670
stoichiometry: 1.0
species: 765556
type: SpeciesReference

831346
units: 345062
value: 3.0779838E-17
type: LocalParameter

767416
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 763757
type: Species

830823
units: 344978
value: 5.0E-18
type: LocalParameter

352706
stoichiometry: 1.0
species: 765576
type: SpeciesReference

355670
stoichiometry: 1.0
species: 766376
type: SpeciesReference

766176
constant: false
boundary condition: false
has only substance units: false
initial concentration: 2.04433333333333E-215
initial amount: NaN
in compartment: 763776
type: Species

770296
kinetic law: 346075
product: 346063
reactant: 346051
reactant: 346039
fast: false
reversible: true
type: Reaction

345979
local parameters: 830055
local parameters: 830052
notes: kf*PKA_slash_R2C2_minus_cAMP*cAMP-kb*PKA_slash_R2C2_minus_cAMP2
type: KineticLaw

830181
units: 344978
value: 9.0E-16
type: LocalParameter

768196
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 763757
type: Species

345291
stoichiometry: 1.0
species: 764796
type: SpeciesReference

350699
local parameters: 830568
notes: k3*PKA_minus_active_slash_PKA_sbo_6_sbc__slash_PKA_sbo_6_sbc__cplx
type: KineticLaw

830205
units: 345062
value: 0.0
type: LocalParameter

766816
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 763776
type: Species

348211
stoichiometry: 1.0
species: 763976
type: SpeciesReference

772456
kinetic law: 351139
product: 351127
reactant: 351115
reactant: 351102
fast: false
reversible: true
type: Reaction

776275
kinetic law: 361085
product: 361073
product: 361061
reactant: 361049
fast: false
reversible: false
type: Reaction

770616
kinetic law: 346786
product: 346774
reactant: 346762
notes: Diffusional equilibrium between PSD- and cytosolic compartment. According to D. Bary in Cell Movements 2nd ed 2001 D for proteins is 5e-7 cm^2/s giving 10 ms for a translocation of 1 um.
fast: false
reversible: true
type: Reaction

349672
local parameters: 830475
local parameters: 830472
notes: k1*AMPAR_slash_A845_star__B*PKA_minus_active-k2*PKA_minus_active_slash_PKA_sbo_28_sbc__slash_PKA_sbo_28_sbc__cplx
type: KineticLaw

830986
units: 345062
value: 4.99998E-18
type: LocalParameter

776335
kinetic law: 361230
product: 361218
reactant: 361206
reactant: 361194
fast: false
reversible: true
type: Reaction

357314
stoichiometry: 1.0
species: 766376
type: SpeciesReference

359973
local parameters: 831430
local parameters: 831427
notes: k1*AMPAR_slash_A831_star__B845_star_*CaM_Ca_n_minus_CaNAB-k2*CaM_Ca_n_minus_CaNAB_slash_PP2B_sbo_22_sbc__slash_PP2B_sbo_22_sbc__cplx
type: KineticLaw

830568
units: 344978
value: 5.4E-16
type: LocalParameter

346604
stoichiometry: 1.0
species: 767616
type: SpeciesReference

768356
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 763757
type: Species

347039
stoichiometry: 1.0
species: 767516
type: SpeciesReference

768876
notes: This isn\'t explicitly present in the M&L model, but is obviously needed. I assume its conc is fixed at 1uM for now, which is a bit high. PLA2 is stim 7x by PIP2 @ 0.5 uM (Leslie and Channon BBA 1045:261(1990) Leslie and Channon say PIP2 is present at 0.1 - 0.2mol% range in membs, which comes to 50 nM. Ref is Majerus et al Cell 37 pp 701-703 1984 Lets use a lower level of 30 nM, same ref....
constant: true
boundary condition: true
has only substance units: false
initial concentration: 2.5
initial amount: NaN
in compartment: 763757
type: Species

764776
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 763757
type: Species

355338
stoichiometry: 1.0
species: 766376
type: SpeciesReference

831517
units: 345062
value: 1.8106416E-16
type: LocalParameter

345738
local parameters: 830025
local parameters: 830022
notes: kf*PP1_slash_PP1_minus_I1-kb*PP1_minus_active*PP1_slash_I1
type: KineticLaw

831661
units: 345062
value: 2.011824E-17
type: LocalParameter

771536
kinetic law: 348899
product: 348887
reactant: 348875
reactant: 348863
fast: false
reversible: true
type: Reaction

348622
stoichiometry: 1.0
species: 764036
type: SpeciesReference

769436
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 763757
type: Species

831244
units: 344978
value: 3.5E-18
type: LocalParameter

775075
kinetic law: 358159
product: 358146
product: 358134
reactant: 358122
fast: false
reversible: false
type: Reaction

774655
kinetic law: 357097
product: 357085
product: 357073
reactant: 357061
fast: false
reversible: false
type: Reaction

360228
stoichiometry: 1.0
species: 767396
type: SpeciesReference

353010
stoichiometry: 1.0
species: 765536
type: SpeciesReference

830247
units: 344978
value: 8.0E-20
type: LocalParameter

358255
local parameters: 831271
notes: k3*PP1_minus_active_PSD_slash_PP1_sbo_30_sbc__slash_PP1_sbo_30_sbc__cplx
type: KineticLaw

776775
kinetic law: 362295
product: 362283
reactant: 362271
reactant: 362259
fast: false
reversible: true
type: Reaction

345678
stoichiometry: 1.0
species: 764916
type: SpeciesReference

774615
kinetic law: 356905
product: 356893
product: 356881
reactant: 356869
fast: false
reversible: false
type: Reaction

349551
stoichiometry: 1.0
species: 763956
type: SpeciesReference

765656
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 763757
type: Species

361037
local parameters: 831529
local parameters: 831526
notes: k1*AMPAR_memb_slash_A845_star__B845_star_*CaM_Ca_n_minus_CaNAB-k2*CaM_Ca_n_minus_CaNAB_slash_PP2B_slash_PP2B_cplx
type: KineticLaw

353710
local parameters: 830850
notes: k3*actCaMKII_minus_PSD_slash_CaMKII_sbo_3_sbc__slash_CaMKII_sbo_3_sbc__cplx
type: KineticLaw

358812
stoichiometry: 1.0
species: 767216
type: SpeciesReference

775655
kinetic law: 359587
product: 359575
reactant: 359563
reactant: 359551
fast: false
reversible: true
type: Reaction

351894
stoichiometry: 1.0
species: 769056
type: SpeciesReference

831130
units: 345062
value: 8.7498E-18
type: LocalParameter

347543
local parameters: 830265
local parameters: 830262
notes: kf*CaMKII_minus_CaM_minus_PSD-kb*CaM_minus_Ca4_minus_PSD*CaMKII_minus_PSD
type: KineticLaw

352866
stoichiometry: 1.0
species: 765636
type: SpeciesReference

358050
stoichiometry: 1.0
species: 766376
type: SpeciesReference

346798
stoichiometry: 1.0
species: 766356
type: SpeciesReference

352245
stoichiometry: 1.0
species: 765076
type: SpeciesReference

354599
stoichiometry: 1.0
species: 769136
type: SpeciesReference

776815
kinetic law: 362392
product: 362380
reactant: 362368
reactant: 362355
fast: false
reversible: true
type: Reaction

770656
kinetic law: 346883
product: 346871
reactant: 346858
reactant: 346846
notes: K inhib = 1nM from Cohen Ann Rev Bioch 1989, 4 nM from Foukes et al Assume 2 nM. kf /kb = 8.333e-4
fast: false
reversible: true
type: Reaction

768316
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 763757
type: Species

766416
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 763776
type: Species

353118
stoichiometry: 1.0
species: 769096
type: SpeciesReference

348512
local parameters: 830367
local parameters: 830364
notes: k1*AMPAR_slash_A_B*PKA_minus_active-k2*PKA_minus_active_slash_PKA_sbo_17_sbc__slash_PKA_sbo_17_sbc__cplx
type: KineticLaw

353974
stoichiometry: 1.0
species: 768676
type: SpeciesReference

771436
kinetic law: 348658
product: 348646
product: 348634
reactant: 348622
fast: false
reversible: false
type: Reaction

348187
stoichiometry: 1.0
species: 765556
type: SpeciesReference

356368
local parameters: 831097
local parameters: 831094
notes: k1*AMPAR_memb_slash_A831_star__B*PP1_minus_active_PSD-k2*PP1_minus_active_PSD_slash_PP1_sbo_11_sbc__slash_PP1_sbo_11_sbc__cplx
type: KineticLaw

830799
units: 345062
value: 4.99998E-20
type: LocalParameter

355374
stoichiometry: 1.0
species: 766376
type: SpeciesReference

830208
units: 344978
value: 8.0E-21
type: LocalParameter

355911
stoichiometry: 1.0
species: 768536
type: SpeciesReference

776735
kinetic law: 362198
product: 362186
reactant: 362173
reactant: 362161
fast: false
reversible: true
type: Reaction

361641
stoichiometry: 1.0
species: 768536
type: SpeciesReference

831457
units: 344978
value: 7.2E-16
type: LocalParameter

766356
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 763776
type: Species

346027
local parameters: 830061
local parameters: 830058
notes: kf*PKA_slash_R2C2_minus_cAMP2*cAMP-kb*PKA_slash_R2C2_minus_cAMP3
type: KineticLaw

768396
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 763757
type: Species

830298
units: 344978
value: 2.25E-16
type: LocalParameter

351554
stoichiometry: 1.0
species: 768636
type: SpeciesReference

830364
units: 345062
value: 3.5998992E-16
type: LocalParameter

355522
stoichiometry: 1.0
species: 768516
type: SpeciesReference

830565
units: 344978
value: 2.16E-15
type: LocalParameter

764136
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 763757
type: Species

349177
stoichiometry: 1.0
species: 764116
type: SpeciesReference

774236
kinetic law: 355449
product: 355437
product: 355424
reactant: 355412
fast: false
reversible: false
type: Reaction

358702
local parameters: 831313
local parameters: 831310
notes: k1*AC_slash_AC2*PKC_minus_active-k2*PKC_minus_active_slash_phosph_minus_AC2_slash_phosph_minus_AC2_cplx
type: KineticLaw

767576
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 763757
type: Species

354106
stoichiometry: 1.0
species: 768796
type: SpeciesReference

355923
stoichiometry: 1.0
species: 766376
type: SpeciesReference

354891
stoichiometry: 1.0
species: 766376
type: SpeciesReference

350735
stoichiometry: 1.0
species: 764416
type: SpeciesReference

351211
stoichiometry: 1.0
species: 763956
type: SpeciesReference

351028
stoichiometry: 1.0
species: 764476
type: SpeciesReference

355862
stoichiometry: 1.0
species: 766376
type: SpeciesReference

831241
units: 344978
value: 1.4E-17
type: LocalParameter

831664
units: 344978
value: 7.2E-16
type: LocalParameter

362453
stoichiometry: 1.0
species: 768756
type: SpeciesReference

347399
local parameters: 830247
local parameters: 830244
notes: kf*AMPAR_slash_A845_star__B831_star_845_star_*Anchor-kb*AMPAR_memb_slash_A845_star__B831_star_845_star_
type: KineticLaw

776015
kinetic law: 360456
product: 360444
reactant: 360432
reactant: 360420
fast: false
reversible: true
type: Reaction

766396
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 763776
type: Species

831559
units: 344978
value: 1.8E-16
type: LocalParameter

346291
stoichiometry: 1.0
species: 765516
type: SpeciesReference

359937
stoichiometry: 1.0
species: 767596
type: SpeciesReference

356007
stoichiometry: 1.0
species: 768536
type: SpeciesReference

771596
kinetic law: 349044
product: 349032
product: 349020
reactant: 349008
fast: false
reversible: false
type: Reaction

831553
units: 345062
value: 2.011824E-17
type: LocalParameter

775715
kinetic law: 359731
product: 359719
product: 359707
reactant: 359695
fast: false
reversible: false
type: Reaction

830472
units: 345062
value: 3.5998992E-16
type: LocalParameter

354999
stoichiometry: 1.0
species: 766416
type: SpeciesReference

360336
stoichiometry: 1.0
species: 767636
type: SpeciesReference

774156
kinetic law: 355254
product: 355242
product: 355230
reactant: 355218
fast: false
reversible: false
type: Reaction

348851
local parameters: 830397
notes: k3*PKA_minus_active_slash_PKA_sbo_19_sbc__slash_PKA_sbo_19_sbc__cplx
type: KineticLaw

769396
constant: false
boundary condition: false
has only substance units: false
initial concentration: 2.0
initial amount: NaN
in compartment: 763757
type: Species

353938
stoichiometry: 1.0
species: 766096
type: SpeciesReference

350290
stoichiometry: 1.0
species: 763956
type: SpeciesReference

357905
stoichiometry: 1.0
species: 767016
type: SpeciesReference

349709
stoichiometry: 1.0
species: 763956
type: SpeciesReference

347435
stoichiometry: 1.0
species: 768776
type: SpeciesReference

360480
stoichiometry: 1.0
species: 767476
type: SpeciesReference

772636
kinetic law: 351578
product: 351566
product: 351554
reactant: 351541
fast: false
reversible: false
type: Reaction

777015
kinetic law: 362874
product: 362862
reactant: 362850
reactant: 362838
fast: false
reversible: true
type: Reaction

831667
units: 344978
value: 1.8E-16
type: LocalParameter

831514
units: 344978
value: 1.8E-16
type: LocalParameter

357422
stoichiometry: 1.0
species: 766916
type: SpeciesReference

772956
kinetic law: 352353
product: 352341
product: 352329
reactant: 352317
fast: false
reversible: false
type: Reaction

349939
stoichiometry: 1.0
species: 763956
type: SpeciesReference

346303
local parameters: 830097
local parameters: 830094
notes: kf*AC_slash_AC2_star_-kb*AC_slash_AC2
type: KineticLaw

766796
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 763776
type: Species

350354
local parameters: 830538
local parameters: 830535
notes: k1*AMPAR_memb_slash_A_B*PKA_minus_active-k2*PKA_minus_active_slash_PKA_sbo_3_sbc__slash_PKA_sbo_3_sbc__cplx
type: KineticLaw

354022
stoichiometry: 1.0
species: 769136
type: SpeciesReference

766756
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 763776
type: Species

354963
local parameters: 830965
notes: k3*PP1_minus_active_PSD_slash_Deph_minus_thr286_slash_Deph_minus_thr286_cplx
type: KineticLaw

359247
local parameters: 831361
notes: k3*CaM_Ca_n_minus_CaNAB_slash_dephosph_minus_PP1_minus_I_star__slash_dephosph_minus_PP1_minus_I_star__cplx
type: KineticLaw

358665
stoichiometry: 1.0
species: 765516
type: SpeciesReference

830868
units: 344978
value: 5.0E-18
type: LocalParameter

351321
stoichiometry: 1.0
species: 764536
type: SpeciesReference

830829
units: 344978
value: 2.0E-17
type: LocalParameter

362161
stoichiometry: 1.0
species: 768816
type: SpeciesReference

830562
units: 345062
value: 3.999888E-17
type: LocalParameter

350084
stoichiometry: 1.0
species: 768696
type: SpeciesReference

830980
units: 344978
value: 8.0E-18
type: LocalParameter

831247
units: 345062
value: 8.7498E-18
type: LocalParameter

344990
exponent: 1.0
scale: 0
multipler: 1.0
kind: LITRE
type: SBMLUnit

348295
stoichiometry: 1.0
species: 763956
type: SpeciesReference

353433
stoichiometry: 1.0
species: 768656
type: SpeciesReference

361375
local parameters: 831559
notes: k3*CaM_Ca_n_minus_CaNAB_slash_PP2B_sbo_3_sbc__slash_PP2B_sbo_3_sbc__cplx
type: KineticLaw

774116
kinetic law: 355158
product: 355146
product: 355133
reactant: 355121
fast: false
reversible: false
type: Reaction

349636
stoichiometry: 1.0
species: 767336
type: SpeciesReference

345931
local parameters: 830049
local parameters: 830046
notes: kf*PKA_slash_R2C2*cAMP-kb*PKA_slash_R2C2_minus_cAMP
type: KineticLaw

767776
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 763757
type: Species

772236
kinetic law: 350603
product: 350591
product: 350579
reactant: 350567
fast: false
reversible: false
type: Reaction

353373
local parameters: 830820
local parameters: 830817
notes: k1*AMPAR_memb_slash_A845_star__B845_star_*actCaMKII_minus_PSD-k2*actCaMKII_minus_PSD_slash_CaMKII_slash_CaMKII_cplx
type: KineticLaw

354382
local parameters: 830913
notes: k3*actCaMKII_minus_PSD_slash_CaMKII_sbo_10_sbc__slash_CaMKII_sbo_10_sbc__cplx
type: KineticLaw

774616
kinetic law: 356953
product: 356941
reactant: 356929
reactant: 356917
fast: false
reversible: true
type: Reaction

773996
kinetic law: 354867
product: 354855
product: 354843
reactant: 354831
fast: false
reversible: false
type: Reaction

830983
units: 344978
value: 2.0E-18
type: LocalParameter

354782
stoichiometry: 1.0
species: 768536
type: SpeciesReference

831556
units: 344978
value: 7.2E-16
type: LocalParameter

355278
stoichiometry: 1.0
species: 766376
type: SpeciesReference

346943
stoichiometry: 1.0
species: 767256
type: SpeciesReference

767636
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 763757
type: Species

345630
stoichiometry: 1.0
species: 764876
type: SpeciesReference

357049
local parameters: 831160
local parameters: 831157
notes: k1*AMPAR_memb_slash_A831_star__B831_star_845_star_*PP1_minus_active_PSD-k2*PP1_minus_active_PSD_slash_PP1_sbo_18_sbc__slash_PP1_sbo_18_sbc__cplx
type: KineticLaw

348139
stoichiometry: 1.0
species: 763896
type: SpeciesReference

358629
stoichiometry: 1.0
species: 764836
type: SpeciesReference

829950
units: 345062
value: 4.4998254E-14
type: LocalParameter

345074
exponent: 2.0
scale: 0
multipler: 1.0
kind: LITRE
type: SBMLUnit

349020
stoichiometry: 1.0
species: 767596
type: SpeciesReference

775275
kinetic law: 358653
product: 358641
product: 358629
product: 358617
reactant: 358605
fast: false
reversible: false
type: Reaction

352974
stoichiometry: 1.0
species: 765696
type: SpeciesReference

360929
stoichiometry: 1.0
species: 768056
type: SpeciesReference

350832
stoichiometry: 1.0
species: 764436
type: SpeciesReference

766116
constant: false
boundary condition: false
has only substance units: false
initial concentration: 1.80016666666667E-215
initial amount: NaN
in compartment: 763776
type: Species

360868
stoichiometry: 1.0
species: 767536
type: SpeciesReference

356977
stoichiometry: 1.0
species: 768636
type: SpeciesReference

773376
kinetic law: 353373
product: 353361
reactant: 353349
reactant: 353337
fast: false
reversible: true
type: Reaction

830361
units: 344978
value: 8.1E-16
type: LocalParameter

362343
local parameters: 831649
notes: k3*CaM_Ca_n_minus_CaNAB_slash_PP2B_sbo_13_sbc__slash_PP2B_sbo_13_sbc__cplx
type: KineticLaw

346351
stoichiometry: 1.0
species: 765636
type: SpeciesReference

361979
stoichiometry: 1.0
species: 767636
type: SpeciesReference

359139
stoichiometry: 1.0
species: 767636
type: SpeciesReference

351930
stoichiometry: 1.0
species: 764756
type: SpeciesReference

773416
kinetic law: 353470
product: 353457
reactant: 353445
reactant: 353433
fast: false
reversible: true
type: Reaction

351773
local parameters: 830667
notes: k3*CaMKII_slash_tot_CaM_CaMKII_slash_CaM_act_286_slash_CaM_act_286_cplx
type: KineticLaw

771036
kinetic law: 347689
product: 347677
reactant: 347664
notes: Represents both synthesis and degradation of the receptor. The rate is set to be rather fast for now. The forward rate also includes scaling terms because the AMPAR_bulk is in the dendritic volume of 5e-18. This means that we need to lower Kf to account for the difference in volumes. Effectively Kf is 1/sec, but the scaled version becomes 9e-20/5e-18 = 0.018
fast: false
reversible: true
type: Reaction

357530
local parameters: 831205
local parameters: 831202
notes: k1*AMPAR_memb_slash_A_B831_star_*PP1_minus_active_PSD-k2*PP1_minus_active_PSD_slash_PP1_sbo_23_sbc__slash_PP1_sbo_23_sbc__cplx
type: KineticLaw

360372
stoichiometry: 1.0
species: 767936
type: SpeciesReference

765156
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.00127907407407407
initial amount: NaN
in compartment: 763757
type: Species

357494
stoichiometry: 1.0
species: 768556
type: SpeciesReference

830319
units: 345062
value: 2.2062942E-16
type: LocalParameter

830640
units: 344978
value: 5.4E-16
type: LocalParameter

830046
units: 345062
value: 4.86E-15
type: LocalParameter

358110
local parameters: 831259
local parameters: 831256
notes: k1*AMPAR_memb_slash_A831_star__B831_star_845_star_*PP1_minus_active_PSD-k2*PP1_minus_active_PSD_slash_PP1_sbo_29_sbc__slash_PP1_sbo_29_sbc__cplx
type: KineticLaw

774456
kinetic law: 356368
product: 356356
reactant: 356344
reactant: 356332
fast: false
reversible: true
type: Reaction

357097
local parameters: 831163
notes: k3*PP1_minus_active_PSD_slash_PP1_sbo_18_sbc__slash_PP1_sbo_18_sbc__cplx
type: KineticLaw

357857
stoichiometry: 1.0
species: 766376
type: SpeciesReference

763896
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 763757
type: Species

350471
stoichiometry: 1.0
species: 764356
type: SpeciesReference

830463
units: 345062
value: 3.5998992E-16
type: LocalParameter

767196
constant: false
boundary condition: false
has only substance units: false
initial concentration: 4.00703703703704E-5
initial amount: NaN
in compartment: 763757
type: Species

360021
local parameters: 831433
notes: k3*CaM_Ca_n_minus_CaNAB_slash_PP2B_sbo_22_sbc__slash_PP2B_sbo_22_sbc__cplx
type: KineticLaw

351725
local parameters: 830664
local parameters: 830661
notes: k1*CaMKII_slash_CaMKII_minus_CaM*CaMKII_slash_tot_CaM_CaMKII-k2*CaMKII_slash_tot_CaM_CaMKII_slash_CaM_act_286_slash_CaM_act_286_cplx
type: KineticLaw

361194
stoichiometry: 1.0
species: 768656
type: SpeciesReference

362064
stoichiometry: 1.0
species: 768676
type: SpeciesReference

774496
kinetic law: 356569
product: 356557
reactant: 356545
reactant: 356533
fast: false
reversible: true
type: Reaction

350406
local parameters: 830541
notes: k3*PKA_minus_active_slash_PKA_sbo_3_sbc__slash_PKA_sbo_3_sbc__cplx
type: KineticLaw

350519
stoichiometry: 1.0
species: 768616
type: SpeciesReference

359829
local parameters: 831415
notes: k3*CaM_Ca_n_minus_CaNAB_slash_PP2B_sbo_20_sbc__slash_PP2B_sbo_20_sbc__cplx
type: KineticLaw

763856
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 763757
type: Species

358689
stoichiometry: 1.0
species: 767196
type: SpeciesReference

356115
stoichiometry: 1.0
species: 766376
type: SpeciesReference

830571
units: 345062
value: 3.999888E-17
type: LocalParameter

768776
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 763776
type: Species

354927
stoichiometry: 1.0
species: 766396
type: SpeciesReference

345895
stoichiometry: 1.0
species: 765276
type: SpeciesReference

830901
units: 344978
value: 2.0E-17
type: LocalParameter

357954
stoichiometry: 1.0
species: 766376
type: SpeciesReference

766636
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 763776
type: Species

830865
units: 344978
value: 2.0E-17
type: LocalParameter

830250
units: 345062
value: 1.08E-19
type: LocalParameter

773456
kinetic law: 353566
product: 353554
reactant: 353542
reactant: 353530
fast: false
reversible: true
type: Reaction

765196
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 763757
type: Species

774495
kinetic law: 356521
product: 356509
product: 356497
reactant: 356485
fast: false
reversible: false
type: Reaction

346822
stoichiometry: 1.0
species: 766376
type: SpeciesReference

360819
stoichiometry: 1.0
species: 767636
type: SpeciesReference

361339
stoichiometry: 1.0
species: 768136
type: SpeciesReference

362814
stoichiometry: 1.0
species: 769456
type: SpeciesReference

771336
kinetic law: 348415
product: 348403
reactant: 348391
reactant: 348379
fast: false
reversible: true
type: Reaction

362706
stoichiometry: 1.0
species: 765816
type: SpeciesReference

775975
kinetic law: 360360
product: 360348
reactant: 360336
reactant: 360324
fast: false
reversible: true
type: Reaction

362682
local parameters: 831682
local parameters: 831679
notes: k1*CaMKII_minus_thr286_minus_PSD*tot_minus_CaM_minus_CaMKII_minus_PSD-k2*tot_minus_CaM_minus_CaMKII_minus_PSD_slash_CaM_minus_act_minus_305_minus_PSD_slash_CaM_minus_act_minus_305_minus_PSD_cplx
type: KineticLaw

767156
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.00538592592592593
initial amount: NaN
in compartment: 763757
type: Species

767676
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 763757
type: Species

359102
local parameters: 831349
local parameters: 831346
notes: k1*PP1_slash_I1_star_*CaM_Ca_n_minus_CaNAB-k2*CaM_Ca_n_minus_CaNAB_slash_dephosph_inhib1_slash_dephosph_inhib1_cplx
type: KineticLaw

831562
units: 345062
value: 2.011824E-17
type: LocalParameter

349975
stoichiometry: 1.0
species: 764256
type: SpeciesReference

348598
stoichiometry: 1.0
species: 764036
type: SpeciesReference

773156
kinetic law: 352841
product: 352829
product: 352817
reactant: 352805
fast: false
reversible: false
type: Reaction

349346
stoichiometry: 1.0
species: 767596
type: SpeciesReference

772736
kinetic law: 351822
product: 351809
reactant: 351797
reactant: 351785
notes: See Hanson and Schulman again, for afterburst rates of phosph.
fast: false
reversible: true
type: Reaction

830904
units: 344978
value: 5.0E-18
type: LocalParameter

350194
stoichiometry: 1.0
species: 763956
type: SpeciesReference

347315
stoichiometry: 1.0
species: 767456
type: SpeciesReference

356821
stoichiometry: 1.0
species: 768816
type: SpeciesReference

831238
units: 345062
value: 8.7498E-18
type: LocalParameter

831460
units: 344978
value: 1.8E-16
type: LocalParameter

361436
stoichiometry: 1.0
species: 768156
type: SpeciesReference

764076
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 763757
type: Species

360444
stoichiometry: 1.0
species: 767956
type: SpeciesReference

350316
stoichiometry: 1.0
species: 768516
type: SpeciesReference

775935
kinetic law: 360264
product: 360252
reactant: 360240
reactant: 360228
fast: false
reversible: true
type: Reaction

358788
stoichiometry: 1.0
species: 767216
type: SpeciesReference

830466
units: 344978
value: 2.16E-15
type: LocalParameter

771376
kinetic law: 348512
product: 348500
reactant: 348488
reactant: 348476
fast: false
reversible: true
type: Reaction

830043
units: 344978
value: 9.0E-17
type: LocalParameter

355706
stoichiometry: 1.0
species: 766556
type: SpeciesReference

348730
stoichiometry: 1.0
species: 767536
type: SpeciesReference

345485
stoichiometry: 2.0
species: 765956
type: SpeciesReference

774455
kinetic law: 356319
product: 356307
product: 356295
reactant: 356283
fast: false
reversible: false
type: Reaction

351443
stoichiometry: 1.0
species: 764556
type: SpeciesReference

776115
kinetic law: 360698
product: 360686
product: 360674
reactant: 360662
fast: false
reversible: false
type: Reaction

360977
stoichiometry: 1.0
species: 767636
type: SpeciesReference

831052
units: 344978
value: 6.8E-18
type: LocalParameter

767116
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 763776
type: Species

354178
stoichiometry: 1.0
species: 769136
type: SpeciesReference

765076
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.111111111111111
initial amount: NaN
in compartment: 763757
type: Species

350182
stoichiometry: 1.0
species: 768696
type: SpeciesReference

356187
stoichiometry: 1.0
species: 766656
type: SpeciesReference

831307
units: 344978
value: 3.15E-17
type: LocalParameter

356223
local parameters: 831082
notes: k3*PP1_minus_active_PSD_slash_PP1_sbo_9_sbc__slash_PP1_sbo_9_sbc__cplx
type: KineticLaw

772516
kinetic law: 351284
product: 351272
product: 351259
reactant: 351247
fast: false
reversible: false
type: Reaction

360179
stoichiometry: 1.0
species: 767896
type: SpeciesReference

355230
stoichiometry: 1.0
species: 768836
type: SpeciesReference

345786
local parameters: 830031
local parameters: 830028
notes: kf*Ca^2*PP2B_slash_CaNAB_minus_Ca2-kb*CaNAB_minus_Ca4
type: KineticLaw

766716
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 763776
type: Species

353046
stoichiometry: 1.0
species: 765776
type: SpeciesReference

830355
units: 345062
value: 5.99994E-17
type: LocalParameter

831670
units: 345062
value: 3.336012E-18
type: LocalParameter

359865
stoichiometry: 1.0
species: 767836
type: SpeciesReference

352341
stoichiometry: 1.0
species: 765076
type: SpeciesReference

830989
units: 344978
value: 8.0E-18
type: LocalParameter

358922
stoichiometry: 1.0
species: 764876
type: SpeciesReference

768016
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 763757
type: Species

830253
units: 344978
value: 8.0E-20
type: LocalParameter

346399
stoichiometry: 1.0
species: 763916
type: SpeciesReference

830469
units: 344978
value: 5.4E-16
type: LocalParameter

775315
kinetic law: 358751
product: 358738
product: 358726
reactant: 358714
fast: false
reversible: false
type: Reaction

830316
units: 344978
value: 2.25E-16
type: LocalParameter

355302
local parameters: 830998
local parameters: 830995
notes: k1*AMPAR_memb_slash_A845_star__B845_star_*PP1_minus_active_PSD-k2*PP1_minus_active_PSD_slash_PP1_slash_PP1_cplx
type: KineticLaw

362283
stoichiometry: 1.0
species: 768336
type: SpeciesReference

831466
units: 344978
value: 7.2E-16
type: LocalParameter

353190
stoichiometry: 1.0
species: 765856
type: SpeciesReference

362898
stoichiometry: 1.0
species: 765776
type: SpeciesReference

351139
local parameters: 830610
local parameters: 830607
notes: k1*AMPAR_memb_slash_A_B831_star_*PKA_minus_active-k2*PKA_minus_active_slash_PKA_sbo_11_sbc__slash_PKA_sbo_11_sbc__cplx
type: KineticLaw

352172
stoichiometry: 1.0
species: 766316
type: SpeciesReference

358898
local parameters: 831331
local parameters: 831328
notes: k1*CaM_slash_neurogranin_minus_CaM_PSD*PKC_minus_active-k2*PKC_minus_active_slash_PKC_minus_phosph_minus_ng_minus_CaM_PSD_slash_PKC_minus_phosph_minus_ng_minus_CaM_PSD_cplx
type: KineticLaw

775355
kinetic law: 358849
product: 358837
product: 358825
reactant: 358812
fast: false
reversible: false
type: Reaction

347652
local parameters: 830283
local parameters: 830280
notes: kf*basal_CaMKII_PSD_control-kb*basal_CaMKII_PSD
type: KineticLaw

352744
local parameters: 830760
notes: k3*AC_slash_cAMP_minus_PDE_slash_PDE_slash_PDE_cplx
type: KineticLaw

354819
local parameters: 830953
local parameters: 830950
notes: k1*AMPAR_memb_slash_A831_star__B*actCaMKII_minus_PSD-k2*actCaMKII_minus_PSD_slash_CaMKII_sbo_15_sbc__slash_CaMKII_sbo_15_sbc__cplx
type: KineticLaw

776955
kinetic law: 362730
product: 362718
product: 362706
reactant: 362694
fast: false
reversible: false
type: Reaction

765496
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 763757
type: Species

831412
units: 344978
value: 7.2E-16
type: LocalParameter

359719
stoichiometry: 1.0
species: 767636
type: SpeciesReference

351664
stoichiometry: 1.0
species: 769036
type: SpeciesReference

831058
units: 345062
value: 8.7498E-18
type: LocalParameter

359466
stoichiometry: 1.0
species: 767636
type: SpeciesReference

830049
units: 344978
value: 2.97E-15
type: LocalParameter

359078
stoichiometry: 1.0
species: 767636
type: SpeciesReference

774515
kinetic law: 356617
product: 356605
product: 356593
reactant: 356581
fast: false
reversible: false
type: Reaction

772796
kinetic law: 351968
product: 351955
product: 351942
reactant: 351930
fast: false
reversible: false
type: Reaction

350432
stoichiometry: 1.0
species: 763956
type: SpeciesReference

353166
stoichiometry: 1.0
species: 765856
type: SpeciesReference

831463
units: 345062
value: 1.8106416E-16
type: LocalParameter

346496
stoichiometry: 1.0
species: 767616
type: SpeciesReference

772096
kinetic law: 350254
product: 350242
reactant: 350230
reactant: 350218
fast: false
reversible: true
type: Reaction

350772
stoichiometry: 1.0
species: 768616
type: SpeciesReference

359539
local parameters: 831388
notes: k3*CaM_Ca_n_minus_CaNAB_slash_PP2B_sbo_17_sbc__slash_PP2B_sbo_17_sbc__cplx
type: KineticLaw

353650
stoichiometry: 1.0
species: 766036
type: SpeciesReference

830358
units: 344978
value: 3.24E-15
type: LocalParameter

357893
stoichiometry: 1.0
species: 766376
type: SpeciesReference

352829
stoichiometry: 1.0
species: 765596
type: SpeciesReference

354660
stoichiometry: 1.0
species: 769136
type: SpeciesReference

831055
units: 344978
value: 1.7E-18
type: LocalParameter

831415
units: 344978
value: 1.8E-16
type: LocalParameter

765596
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 763757
type: Species

351102
stoichiometry: 1.0
species: 768556
type: SpeciesReference

769076
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 763776
type: Species

356031
local parameters: 831064
notes: k3*PP1_minus_active_PSD_slash_PP1_sbo_7_sbc__slash_PP1_sbo_7_sbc__cplx
type: KineticLaw

346207
stoichiometry: 1.0
species: 765436
type: SpeciesReference

357217
stoichiometry: 1.0
species: 766376
type: SpeciesReference

830862
units: 345062
value: 2.77776E-19
type: LocalParameter

346714
local parameters: 830151
local parameters: 830148
notes: kf*CaMKII_minus_thr286_minus_PSD*CaM_minus_Ca4_minus_PSD-kb*CaMKII_minus_thr286_minus_CaM_minus_PSD
type: KineticLaw

355971
stoichiometry: 1.0
species: 766616
type: SpeciesReference

766856
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 763776
type: Species

355814
stoichiometry: 1.0
species: 768616
type: SpeciesReference

774875
kinetic law: 357675
product: 357663
product: 357651
reactant: 357639
fast: false
reversible: false
type: Reaction

765556
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.555555555555556
initial amount: NaN
in compartment: 763757
type: Species

348355
stoichiometry: 1.0
species: 763956
type: SpeciesReference

830907
units: 345062
value: 2.77776E-19
type: LocalParameter

362417
stoichiometry: 1.0
species: 768576
type: SpeciesReference

350206
local parameters: 830523
notes: k3*PKA_minus_active_slash_PKA_sbo_1_sbc__slash_PKA_sbo_1_sbc__cplx
type: KineticLaw

362742
stoichiometry: 1.0
species: 765756
type: SpeciesReference

766676
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 763776
type: Species

349418
stoichiometry: 1.0
species: 763956
type: SpeciesReference

361593
stoichiometry: 1.0
species: 767636
type: SpeciesReference

357001
local parameters: 831154
notes: k3*PP1_minus_active_PSD_slash_PP1_sbo_17_sbc__slash_PP1_sbo_17_sbc__cplx
type: KineticLaw

346075
local parameters: 830067
local parameters: 830064
notes: kf*cAMP*PKA_slash_R2C2_minus_cAMP3-kb*PKA_slash_R2C2_minus_cAMP4
type: KineticLaw

831169
units: 344978
value: 6.8E-18
type: LocalParameter

772056
kinetic law: 350158
product: 350146
reactant: 350133
reactant: 350121
fast: false
reversible: true
type: Reaction

355596
local parameters: 831025
local parameters: 831022
notes: k1*AMPAR_memb_slash_A_B845_star_*PP1_minus_active_PSD-k2*PP1_minus_active_PSD_slash_PP1_sbo_3_sbc__slash_PP1_sbo_3_sbc__cplx
type: KineticLaw

830256
units: 345062
value: 1.08E-19
type: LocalParameter

768836
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 763776
type: Species

831166
units: 345062
value: 8.7498E-18
type: LocalParameter

361714
local parameters: 831592
local parameters: 831589
notes: k1*AMPAR_memb_slash_A831_star_845_star__B*CaM_Ca_n_minus_CaNAB-k2*CaM_Ca_n_minus_CaNAB_slash_PP2B_sbo_7_sbc__slash_PP2B_sbo_7_sbc__cplx
type: KineticLaw

357157
stoichiometry: 1.0
species: 766856
type: SpeciesReference

830310
units: 345062
value: 2.2062942E-16
type: LocalParameter

830649
units: 344978
value: 5.4E-16
type: LocalParameter

831397
units: 344978
value: 1.8E-16
type: LocalParameter

773096
kinetic law: 352694
product: 352682
reactant: 352670
reactant: 352658
notes: Best rates are from Conti et al Biochem 34 7979-7987 1995. Though these are for the Sertoli cell form, it looks like they carry nicely into alternatively spliced brain form. See Sette et al JBC 269:28 18271-18274 Km ~2 uM, Vmax est ~ 10 umol/min/mg for pure form. Brain protein is 93 kD but this was 67. So k3 ~10, k2 ~40, k1 ~4.2e-6
fast: false
reversible: true
type: Reaction

359428
stoichiometry: 1.0
species: 767636
type: SpeciesReference

773736
kinetic law: 354238
product: 354226
reactant: 354214
reactant: 354202
fast: false
reversible: true
type: Reaction

774275
kinetic law: 355546
product: 355534
product: 355522
reactant: 355509
fast: false
reversible: false
type: Reaction

362525
stoichiometry: 1.0
species: 767636
type: SpeciesReference

354334
local parameters: 830910
local parameters: 830907
notes: k1*AMPAR_memb_slash_A845_star__B831_star_*actCaMKII_minus_PSD-k2*actCaMKII_minus_PSD_slash_CaMKII_sbo_10_sbc__slash_CaMKII_sbo_10_sbc__cplx
type: KineticLaw

770176
kinetic law: 345786
product: 345774
reactant: 345762
reactant: 345750
notes: This process is probably much more complicated and involves CaM. However, as I can\'t find detailed info I am bundling this into a single step. Based on Steemer and Klee pg 6863, the Kact is 0.5 uM. kf/kb = 1/(0.5 * 6e5)^2 = 1.11e-11
fast: false
reversible: true
type: Reaction

830688
units: 345062
value: 5.81256E-17
type: LocalParameter

830535
units: 345062
value: 3.999888E-17
type: LocalParameter

773836
kinetic law: 354479
product: 354467
product: 354455
reactant: 354442
fast: false
reversible: false
type: Reaction

350543
stoichiometry: 1.0
species: 764376
type: SpeciesReference

346532
stoichiometry: 1.0
species: 764636
type: SpeciesReference

358159
local parameters: 831262
notes: k3*PP1_minus_active_PSD_slash_PP1_sbo_29_sbc__slash_PP1_sbo_29_sbc__cplx
type: KineticLaw

830607
units: 345062
value: 3.999888E-17
type: LocalParameter

764736
constant: false
boundary condition: false
has only substance units: false
initial concentration: 4.90055555555556E-8
initial amount: NaN
in compartment: 763757
type: Species

355121
stoichiometry: 1.0
species: 766436
type: SpeciesReference

354130
stoichiometry: 1.0
species: 766136
type: SpeciesReference

347135
stoichiometry: 1.0
species: 767296
type: SpeciesReference

359575
stoichiometry: 1.0
species: 767776
type: SpeciesReference

347943
stoichiometry: 1.0
species: 763856
type: SpeciesReference

770136
kinetic law: 345690
product: 345678
reactant: 345666
notes: This is put in to keep the basal levels of neurogranin* experimentally reasonable. From various papers, specially Ramakers et al JBC 270:23 1995 13892-13898, it looks like the basal level of phosph is between 20 and 40%. I est around 25 % The kf of 0.005 gives around this level at basal PKC activity levels of 0.1 uM active PKC.
fast: false
reversible: true
type: Reaction

774276
kinetic law: 355596
product: 355583
reactant: 355570
reactant: 355558
fast: false
reversible: true
type: Reaction

352523
stoichiometry: 1.0
species: 766296
type: SpeciesReference

772116
kinetic law: 350303
product: 350290
product: 350278
reactant: 350266
fast: false
reversible: false
type: Reaction

349238
local parameters: 830433
notes: k3*PKA_minus_active_slash_PKA_sbo_23_sbc__slash_PKA_sbo_23_sbc__cplx
type: KineticLaw

352499
local parameters: 830736
local parameters: 830733
notes: k1*PP1_PSD_slash_I1_star_*CaNAB_minus_Ca4-k2*CaNAB_minus_Ca4_slash_dephosph_inhib1_noCaM_PSD_slash_dephosph_inhib1_noCaM_PSD_cplx
type: KineticLaw

831358
units: 344978
value: 1.224E-16
type: LocalParameter

352281
stoichiometry: 1.0
species: 765076
type: SpeciesReference

350242
stoichiometry: 1.0
species: 764316
type: SpeciesReference

353276
local parameters: 830811
local parameters: 830808
notes: k1*CaMKII_minus_PSD*tot_minus_auto_minus_PSD-k2*tot_minus_auto_minus_PSD_slash_auton_minus_autoph_slash_auton_minus_autoph_cplx
type: KineticLaw

830085
units: 344978
value: 9.0E-17
type: LocalParameter

349129
stoichiometry: 1.0
species: 763956
type: SpeciesReference

356433
stoichiometry: 1.0
species: 768796
type: SpeciesReference

765616
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 763757
type: Species

347195
local parameters: 830217
local parameters: 830214
notes: kf*AMPAR_slash_A835_star_845_star__B835_star_845_star_-kb*AMPAR_slash_AMPAR_deg
type: KineticLaw

349490
stoichiometry: 1.0
species: 764176
type: SpeciesReference

362392
local parameters: 831655
local parameters: 831652
notes: k1*AMPAR_memb_slash_A831_star_845_star__B831_star_*CaM_Ca_n_minus_CaNAB-k2*CaM_Ca_n_minus_CaNAB_slash_PP2B_sbo_14_sbc__slash_PP2B_sbo_14_sbc__cplx
type: KineticLaw

773776
kinetic law: 354334
product: 354322
reactant: 354310
reactant: 354298
fast: false
reversible: true
type: Reaction

831304
units: 344978
value: 1.26E-16
type: LocalParameter

362634
local parameters: 831676
notes: k3*CaM_Ca_n_minus_CaNAB_slash_dephosph_neurogranin_PSD_slash_dephosph_neurogranin_PSD_cplx
type: KineticLaw

768416
constant: false
boundary condition: false
has only substance units: false
initial concentration: 2.0
initial amount: NaN
in compartment: 763776
type: Species

830532
units: 344978
value: 5.4E-16
type: LocalParameter

348839
stoichiometry: 1.0
species: 763956
type: SpeciesReference

766456
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 763776
type: Species

830685
units: 344978
value: 4.5E-17
type: LocalParameter

357784
stoichiometry: 1.0
species: 768636
type: SpeciesReference

346183
stoichiometry: 1.0
species: 763956
type: SpeciesReference

763916
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 763757
type: Species

764936
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 763776
type: Species

347845
stoichiometry: 1.0
species: 763836
type: SpeciesReference

357578
local parameters: 831208
notes: k3*PP1_minus_active_PSD_slash_PP1_sbo_23_sbc__slash_PP1_sbo_23_sbc__cplx
type: KineticLaw

345834
local parameters: 830037
local parameters: 830034
notes: kf*PP2B_slash_CaNAB*Ca^2-kb*PP2B_slash_CaNAB_minus_Ca2
type: KineticLaw

362113
stoichiometry: 1.0
species: 768296
type: SpeciesReference

359671
stoichiometry: 1.0
species: 767796
type: SpeciesReference

348247
stoichiometry: 1.0
species: 765596
type: SpeciesReference

350663
stoichiometry: 1.0
species: 764396
type: SpeciesReference

359187
stoichiometry: 1.0
species: 767696
type: SpeciesReference

345400
stoichiometry: 1.0
species: 764796
type: SpeciesReference

830313
units: 344978
value: 9.0E-16
type: LocalParameter

831418
units: 345062
value: 1.8106416E-16
type: LocalParameter

347471
stoichiometry: 1.0
species: 768436
type: SpeciesReference

831394
units: 344978
value: 7.2E-16
type: LocalParameter

361508
stoichiometry: 1.0
species: 768176
type: SpeciesReference

830646
units: 344978
value: 2.16E-15
type: LocalParameter

361484
stoichiometry: 1.0
species: 768776
type: SpeciesReference

349527
local parameters: 830460
notes: k3*PKA_minus_active_slash_PKA_sbo_26_sbc__slash_PKA_sbo_26_sbc__cplx
type: KineticLaw

353542
stoichiometry: 1.0
species: 769136
type: SpeciesReference

348778
stoichiometry: 1.0
species: 763956
type: SpeciesReference

776435
kinetic law: 361472
product: 361460
product: 361448
reactant: 361436
fast: false
reversible: false
type: Reaction

345227
local parameters: 829959
local parameters: 829956
notes: kf*CaM_minus_Ca4*CaMKII_slash_CaMKII-kb*CaMKII_slash_CaMKII_minus_CaM
type: KineticLaw

345038
exponent: -2.0
scale: -6
multipler: 1.0
kind: MOLE
type: SBMLUnit

360650
local parameters: 831493
local parameters: 831490
notes: k1*AMPAR_slash_A845_star__B845_star_*CaM_Ca_n_minus_CaNAB-k2*CaM_Ca_n_minus_CaNAB_slash_PP2B_sbo_29_sbc__slash_PP2B_sbo_29_sbc__cplx
type: KineticLaw

770816
kinetic law: 347231
product: 347219
reactant: 347207
fast: false
reversible: true
type: Reaction

830947
units: 344978
value: 5.0E-18
type: LocalParameter

831355
units: 345062
value: 3.0779838E-17
type: LocalParameter

352597
local parameters: 830745
local parameters: 830742
notes: kcat*AC_slash_AC1_minus_CaM*AC_slash_ATP/(Km+AC_slash_ATP)
type: KineticLaw

356472
local parameters: 831106
local parameters: 831103
notes: k1*AMPAR_memb_slash_A845_star__B831_star_845_star_*PP1_minus_active_PSD-k2*PP1_minus_active_PSD_slash_PP1_sbo_12_sbc__slash_PP1_sbo_12_sbc__cplx
type: KineticLaw

356869
stoichiometry: 1.0
species: 766796
type: SpeciesReference

347207
stoichiometry: 1.0
species: 767436
type: SpeciesReference

831616
units: 345062
value: 2.011824E-17
type: LocalParameter

361085
local parameters: 831532
notes: k3*CaM_Ca_n_minus_CaNAB_slash_PP2B_slash_PP2B_cplx
type: KineticLaw

356797
stoichiometry: 1.0
species: 766376
type: SpeciesReference

830139
units: 345062
value: 5.4E-21
type: LocalParameter

358436
stoichiometry: 1.0
species: 766376
type: SpeciesReference

348403
stoichiometry: 1.0
species: 764016
type: SpeciesReference

362850
stoichiometry: 1.0
species: 769456
type: SpeciesReference

767736
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 763757
type: Species

357748
stoichiometry: 1.0
species: 768736
type: SpeciesReference

776495
kinetic law: 361617
product: 361605
reactant: 361593
reactant: 361581
fast: false
reversible: true
type: Reaction

831610
units: 344978
value: 7.2E-16
type: LocalParameter

346640
stoichiometry: 1.0
species: 764776
type: SpeciesReference

352016
local parameters: 830691
local parameters: 830688
notes: k1*PP1_slash_I1_star_*PP2A-k2*PP2A_slash_PP2A_minus_dephosph_minus_I1_slash_PP2A_minus_dephosph_minus_I1_cplx
type: KineticLaw

345149
stoichiometry: 1.0
species: 763797
type: SpeciesReference

346315
stoichiometry: 1.0
species: 765596
type: SpeciesReference

356581
stoichiometry: 1.0
species: 766736
type: SpeciesReference

352414
stoichiometry: 1.0
species: 765196
type: SpeciesReference

351406
stoichiometry: 1.0
species: 763956
type: SpeciesReference

354442
stoichiometry: 1.0
species: 766196
type: SpeciesReference

771696
kinetic law: 349286
product: 349274
reactant: 349262
reactant: 349250
fast: false
reversible: true
type: Reaction

830001
units: 344978
value: 1.0E-16
type: LocalParameter

358400
local parameters: 831286
local parameters: 831283
notes: k1*CaMKII_minus_thr305_minus_PSD*PP1_minus_active_PSD-k2*PP1_minus_active_PSD_slash_Deph_minus_thr305a_slash_Deph_minus_thr305a_cplx
type: KineticLaw

354733
stoichiometry: 1.0
species: 766256
type: SpeciesReference

349394
stoichiometry: 1.0
species: 764156
type: SpeciesReference

765216
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 763757
type: Species

831352
units: 344978
value: 3.06E-17
type: LocalParameter

360131
stoichiometry: 1.0
species: 767496
type: SpeciesReference

356713
local parameters: 831127
notes: k3*PP1_minus_active_PSD_slash_PP1_sbo_14_sbc__slash_PP1_sbo_14_sbc__cplx
type: KineticLaw

770336
kinetic law: 346171
product: 346159
product: 346147
reactant: 346135
fast: false
reversible: true
type: Reaction

831163
units: 344978
value: 1.7E-18
type: LocalParameter

347087
stoichiometry: 1.0
species: 767316
type: SpeciesReference

358002
stoichiometry: 1.0
species: 767036
type: SpeciesReference

351394
stoichiometry: 1.0
species: 768576
type: SpeciesReference

355754
stoichiometry: 1.0
species: 768776
type: SpeciesReference

361750
stoichiometry: 1.0
species: 767636
type: SpeciesReference

358363
stoichiometry: 1.0
species: 768836
type: SpeciesReference

774935
kinetic law: 357821
product: 357808
reactant: 357796
reactant: 357784
fast: false
reversible: true
type: Reaction

830941
units: 345062
value: 2.77776E-19
type: LocalParameter

361605
stoichiometry: 1.0
species: 768196
type: SpeciesReference

345188
stoichiometry: 1.0
species: 763796
type: SpeciesReference

831160
units: 344978
value: 6.8E-18
type: LocalParameter

831391
units: 345062
value: 1.8106416E-16
type: LocalParameter

830040
units: 345062
value: 5.399946E-14
type: LocalParameter

356079
local parameters: 831070
local parameters: 831067
notes: k1*AMPAR_memb_slash_A831_star_845_star__B845_star_*PP1_minus_active_PSD-k2*PP1_minus_active_PSD_slash_PP1_sbo_8_sbc__slash_PP1_sbo_8_sbc__cplx
type: KineticLaw

360614
stoichiometry: 1.0
species: 767396
type: SpeciesReference

770756
kinetic law: 347111
product: 347099
product: 347087
reactant: 347075
fast: false
reversible: true
type: Reaction

362003
local parameters: 831619
local parameters: 831616
notes: k1*AMPAR_memb_slash_A_B831_star_845_star_*CaM_Ca_n_minus_CaNAB-k2*CaM_Ca_n_minus_CaNAB_slash_PP2B_sbo_10_sbc__slash_PP2B_sbo_10_sbc__cplx
type: KineticLaw

362790
stoichiometry: 1.0
species: 768476
type: SpeciesReference

347737
local parameters: 830295
local parameters: 830292
notes: k1*CaMKII_slash_CaMKII_minus_thr286_star__minus_CaM*PP1_minus_active-k2*PP1_minus_active_slash_Deph_minus_thr286_slash_Deph_minus_thr286_cplx
type: KineticLaw

830643
units: 345062
value: 3.999888E-17
type: LocalParameter

359781
local parameters: 831412
local parameters: 831409
notes: k1*AMPAR_slash_A831_star_845_star__B831_star_*CaM_Ca_n_minus_CaNAB-k2*CaM_Ca_n_minus_CaNAB_slash_PP2B_sbo_20_sbc__slash_PP2B_sbo_20_sbc__cplx
type: KineticLaw

768516
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 763776
type: Species

772916
kinetic law: 352257
product: 352245
product: 352233
reactant: 352220
fast: false
reversible: false
type: Reaction

831613
units: 344978
value: 1.8E-16
type: LocalParameter

355412
stoichiometry: 1.0
species: 766496
type: SpeciesReference

351077
stoichiometry: 1.0
species: 763956
type: SpeciesReference

765976
constant: false
boundary condition: false
has only substance units: false
initial concentration: 7.1375E-215
initial amount: NaN
in compartment: 763776
type: Species

764296
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 763757
type: Species

830088
units: 345062
value: 4.4999712E-15
type: LocalParameter

830136
units: 344978
value: 3.0E-18
type: LocalParameter

345569
stoichiometry: 1.0
species: 765916
type: SpeciesReference

830944
units: 344978
value: 2.0E-17
type: LocalParameter

765936
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 763776
type: Species

772276
kinetic law: 350699
product: 350687
product: 350675
reactant: 350663
fast: false
reversible: false
type: Reaction

830682
units: 344978
value: 1.8E-16
type: LocalParameter

359319
stoichiometry: 1.0
species: 766296
type: SpeciesReference

351517
stoichiometry: 1.0
species: 764576
type: SpeciesReference

768576
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 763776
type: Species

357687
stoichiometry: 1.0
species: 768756
type: SpeciesReference

831301
units: 345062
value: 5.507838E-18
type: LocalParameter

775175
kinetic law: 358400
product: 358388
reactant: 358376
reactant: 358363
fast: false
reversible: true
type: Reaction

359030
stoichiometry: 1.0
species: 764856
type: SpeciesReference

353698
stoichiometry: 1.0
species: 769136
type: SpeciesReference

349286
local parameters: 830439
local parameters: 830436
notes: k1*AMPAR_slash_A_B845_star_*PKA_minus_active-k2*PKA_minus_active_slash_PKA_sbo_24_sbc__slash_PKA_sbo_24_sbc__cplx
type: KineticLaw

355012
local parameters: 830971
local parameters: 830968
notes: k1*CaMKII_minus_thr286_minus_PSD*PP1_minus_active_PSD-k2*PP1_minus_active_PSD_slash_Deph_minus_thr286b_slash_Deph_minus_thr286b_cplx
type: KineticLaw

830538
units: 344978
value: 2.16E-15
type: LocalParameter

355790
local parameters: 831043
local parameters: 831040
notes: k1*AMPAR_memb_slash_A831_star_845_star__B845_star_*PP1_minus_active_PSD-k2*PP1_minus_active_PSD_slash_PP1_sbo_5_sbc__slash_PP1_sbo_5_sbc__cplx
type: KineticLaw

830604
units: 344978
value: 5.4E-16
type: LocalParameter

354286
local parameters: 830904
notes: k3*actCaMKII_minus_PSD_slash_CaMKII_sbo_9_sbc__slash_CaMKII_sbo_9_sbc__cplx
type: KineticLaw

361545
stoichiometry: 1.0
species: 768616
type: SpeciesReference

351370
stoichiometry: 1.0
species: 763956
type: SpeciesReference

362922
local parameters: 831703
notes: k3*tot_minus_CaM_minus_CaMKII_minus_PSD_slash_CaM_act_autoph_slash_CaM_act_autoph_cplx
type: KineticLaw

830103
units: 344978
value: 0.0
type: LocalParameter

348694
stoichiometry: 1.0
species: 764037
type: SpeciesReference

775135
kinetic law: 358303
product: 358291
reactant: 358279
reactant: 358267
fast: false
reversible: true
type: Reaction

346919
stoichiometry: 1.0
species: 763796
type: SpeciesReference

354226
stoichiometry: 1.0
species: 766156
type: SpeciesReference

830403
units: 344978
value: 2.16E-15
type: LocalParameter

356989
stoichiometry: 1.0
species: 766376
type: SpeciesReference

768536
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 763776
type: Species

361762
local parameters: 831595
notes: k3*CaM_Ca_n_minus_CaNAB_slash_PP2B_sbo_7_sbc__slash_PP2B_sbo_7_sbc__cplx
type: KineticLaw

355742
local parameters: 831037
notes: k3*PP1_minus_active_PSD_slash_PP1_sbo_4_sbc__slash_PP1_sbo_4_sbc__cplx
type: KineticLaw

767696
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 763757
type: Species

349032
stoichiometry: 1.0
species: 763956
type: SpeciesReference

831274
units: 345062
value: 8.7498E-18
type: LocalParameter

831121
units: 345062
value: 8.7498E-18
type: LocalParameter

352986
local parameters: 830784
local parameters: 830781
notes: k1*cAMP*AC_slash_CaM_dot_PDE1-k2*AC_slash_CaM_dot_PDE1_slash_CaM_dot_PDE1_slash_CaM_dot_PDE1_cplx
type: KineticLaw

354539
stoichiometry: 1.0
species: 766216
type: SpeciesReference

347279
stoichiometry: 1.0
species: 767396
type: SpeciesReference

829986
units: 344978
value: 4.5E-19
type: LocalParameter

776515
kinetic law: 361665
product: 361653
product: 361641
reactant: 361629
fast: false
reversible: false
type: Reaction

772296
kinetic law: 350748
product: 350735
reactant: 350723
reactant: 350711
fast: false
reversible: true
type: Reaction

350687
stoichiometry: 1.0
species: 763956
type: SpeciesReference

345858
stoichiometry: 1.0
species: 765176
type: SpeciesReference

356593
stoichiometry: 1.0
species: 768676
type: SpeciesReference

352004
stoichiometry: 1.0
species: 765096
type: SpeciesReference

830193
units: 345062
value: 0.0
type: LocalParameter

776615
kinetic law: 361906
product: 361894
reactant: 361882
reactant: 361870
fast: false
reversible: true
type: Reaction

766476
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 763776
type: Species

831334
units: 344978
value: 3.15E-17
type: LocalParameter

362598
stoichiometry: 1.0
species: 768396
type: SpeciesReference

355682
stoichiometry: 1.0
species: 766556
type: SpeciesReference

831286
units: 344978
value: 8.0E-18
type: LocalParameter

362658
stoichiometry: 1.0
species: 769456
type: SpeciesReference

345943
stoichiometry: 1.0
species: 765296
type: SpeciesReference

352914
stoichiometry: 1.0
species: 765536
type: SpeciesReference

353421
local parameters: 830823
notes: k3*actCaMKII_minus_PSD_slash_CaMKII_slash_CaMKII_cplx
type: KineticLaw

349648
stoichiometry: 1.0
species: 763956
type: SpeciesReference

774735
kinetic law: 357338
product: 357326
reactant: 357314
reactant: 357302
fast: false
reversible: true
type: Reaction

831235
units: 344978
value: 3.5E-18
type: LocalParameter

830616
units: 345062
value: 3.999888E-17
type: LocalParameter

769356
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 763776
type: Species

765776
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 763776
type: Species

771616
kinetic law: 349093
product: 349080
reactant: 349068
reactant: 349056
fast: false
reversible: true
type: Reaction

775775
kinetic law: 359877
product: 359865
reactant: 359853
reactant: 359841
fast: false
reversible: true
type: Reaction

830400
units: 345062
value: 3.5998992E-16
type: LocalParameter

354010
stoichiometry: 1.0
species: 768516
type: SpeciesReference

770536
kinetic law: 346616
product: 346604
product: 346592
reactant: 346580
notes: Rates set by the translocation experiments of Shen and Meyer, Science 1999.
fast: false
reversible: true
type: Reaction

347159
local parameters: 830211
local parameters: 830208
notes: kf*AMPAR_memb_slash_A_B-kb*AMPAR_slash_A_B*Anchor
type: KineticLaw

359307
stoichiometry: 1.0
species: 767716
type: SpeciesReference

831679
units: 345062
value: 9.375E-19
type: LocalParameter

831061
units: 344978
value: 6.8E-18
type: LocalParameter

776935
kinetic law: 362682
product: 362670
reactant: 362658
reactant: 362646
fast: false
reversible: true
type: Reaction

768436
constant: false
boundary condition: false
has only substance units: false
initial concentration: 27.3333333333333
initial amount: NaN
in compartment: 763776
type: Species

770376
kinetic law: 346267
product: 346255
reactant: 346243
reactant: 346231
notes: Half-max at 20 nM CaM (Tang et al JBC 266:13 8595-8603 1991 kb/kf = 20 nM = 12000 #/cell so kf = kb/12000 = kb * 8.333e-5
fast: false
reversible: true
type: Reaction

358376
stoichiometry: 1.0
species: 766376
type: SpeciesReference

348127
local parameters: 830331
local parameters: 830328
notes: k1*CaMKII_slash_CaMK_minus_thr305*PP1_minus_active-k2*PP1_minus_active_slash_Deph_minus_thr305a_slash_Deph_minus_thr305a_cplx
type: KineticLaw

773716
kinetic law: 354190
product: 354178
product: 354166
reactant: 354154
fast: false
reversible: false
type: Reaction

345533
stoichiometry: 1.0
species: 765956
type: SpeciesReference

357458
stoichiometry: 1.0
species: 768596
type: SpeciesReference

772356
kinetic law: 350895
product: 350882
product: 350869
reactant: 350857
fast: false
reversible: false
type: Reaction

349430
local parameters: 830451
notes: k3*PKA_minus_active_slash_PKA_sbo_25_sbc__slash_PKA_sbo_25_sbc__cplx
type: KineticLaw

348065
stoichiometry: 1.0
species: 763797
type: SpeciesReference

830100
units: 344978
value: 9.0E-19
type: LocalParameter

830727
units: 344978
value: 1.224E-17
type: LocalParameter

353830
stoichiometry: 1.0
species: 769136
type: SpeciesReference

767316
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 763757
type: Species

347906
stoichiometry: 1.0
species: 763797
type: SpeciesReference

768476
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 763776
type: Species

764656
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 763757
type: Species

353902
local parameters: 830868
notes: k3*actCaMKII_minus_PSD_slash_CaMKII_sbo_5_sbc__slash_CaMKII_sbo_5_sbc__cplx
type: KineticLaw

831337
units: 345062
value: 3.0024108E-17
type: LocalParameter

830070
units: 344978
value: 5.4E-15
type: LocalParameter

351358
stoichiometry: 1.0
species: 768816
type: SpeciesReference

768956
constant: true
boundary condition: true
has only substance units: false
initial concentration: 0.08
initial amount: NaN
in compartment: 763757
type: Species

348015
stoichiometry: 1.0
species: 763876
type: SpeciesReference

769316
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 763776
type: Species

771656
kinetic law: 349189
product: 349177
reactant: 349165
reactant: 349153
fast: false
reversible: true
type: Reaction

830154
units: 344978
value: 9.0E-15
type: LocalParameter

362501
stoichiometry: 1.0
species: 768376
type: SpeciesReference

360348
stoichiometry: 1.0
species: 767936
type: SpeciesReference

830484
units: 344978
value: 2.16E-15
type: LocalParameter

830769
units: 344978
value: 1.8E-15
type: LocalParameter

774775
kinetic law: 357434
product: 357422
reactant: 357410
reactant: 357398
fast: false
reversible: true
type: Reaction

358195
stoichiometry: 1.0
species: 767076
type: SpeciesReference

352124
stoichiometry: 1.0
species: 765116
type: SpeciesReference

831607
units: 345062
value: 2.011824E-17
type: LocalParameter

359647
stoichiometry: 1.0
species: 767536
type: SpeciesReference

766576
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 763776
type: Species

776655
kinetic law: 362003
product: 361991
reactant: 361979
reactant: 361967
fast: false
reversible: true
type: Reaction

355096
stoichiometry: 1.0
species: 766436
type: SpeciesReference

830763
units: 345062
value: 4.5359838E-16
type: LocalParameter

345907
stoichiometry: 1.0
species: 763916
type: SpeciesReference

361230
local parameters: 831547
local parameters: 831544
notes: k1*AMPAR_memb_slash_A_B845_star_*CaM_Ca_n_minus_CaNAB-k2*CaM_Ca_n_minus_CaNAB_slash_PP2B_sbo_2_sbc__slash_PP2B_sbo_2_sbc__cplx
type: KineticLaw

831523
units: 344978
value: 1.8E-16
type: LocalParameter

831676
units: 344978
value: 6.03E-17
type: LocalParameter

767096
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 763776
type: Species

349819
local parameters: 830487
notes: k3*PKA_minus_active_slash_PKA_sbo_29_sbc__slash_PKA_sbo_29_sbc__cplx
type: KineticLaw

349795
stoichiometry: 1.0
species: 767416
type: SpeciesReference

830196
units: 344978
value: 8.0E-21
type: LocalParameter

765056
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 763757
type: Species

351639
stoichiometry: 1.0
species: 764696
type: SpeciesReference

830157
units: 344978
value: 9.0E-15
type: LocalParameter

346231
stoichiometry: 1.0
species: 763796
type: SpeciesReference

359563
stoichiometry: 1.0
species: 767636
type: SpeciesReference

356665
local parameters: 831124
local parameters: 831121
notes: k1*AMPAR_memb_slash_A_B831_star_845_star_*PP1_minus_active_PSD-k2*PP1_minus_active_PSD_slash_PP1_sbo_14_sbc__slash_PP1_sbo_14_sbc__cplx
type: KineticLaw

830481
units: 345062
value: 3.5998992E-16
type: LocalParameter

347955
stoichiometry: 1.0
species: 764676
type: SpeciesReference

831637
units: 344978
value: 7.2E-16
type: LocalParameter

358508
stoichiometry: 1.0
species: 767156
type: SpeciesReference

830619
units: 344978
value: 2.16E-15
type: LocalParameter

357350
stoichiometry: 1.0
species: 766896
type: SpeciesReference

830028
units: 345014
value: 3.24008424E-16
type: LocalParameter

773296
kinetic law: 353178
product: 353166
reactant: 353154
reactant: 353142
fast: false
reversible: true
type: Reaction

830406
units: 344978
value: 5.4E-16
type: LocalParameter

355133
stoichiometry: 1.0
species: 765776
type: SpeciesReference

355534
stoichiometry: 1.0
species: 766376
type: SpeciesReference

773256
kinetic law: 353082
product: 353070
reactant: 353058
reactant: 353046
fast: false
reversible: true
type: Reaction

349141
local parameters: 830424
notes: k3*PKA_minus_active_slash_PKA_sbo_22_sbc__slash_PKA_sbo_22_sbc__cplx
type: KineticLaw

771476
kinetic law: 348754
product: 348742
product: 348730
reactant: 348718
fast: false
reversible: false
type: Reaction

355060
local parameters: 830974
notes: k3*PP1_minus_active_PSD_slash_Deph_minus_thr286b_slash_Deph_minus_thr286b_cplx
type: KineticLaw

360723
stoichiometry: 1.0
species: 767636
type: SpeciesReference

764276
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 763757
type: Species

354094
local parameters: 830886
notes: k3*actCaMKII_minus_PSD_slash_CaMKII_sbo_7_sbc__slash_CaMKII_sbo_7_sbc__cplx
type: KineticLaw

362222
stoichiometry: 1.0
species: 768756
type: SpeciesReference

345266
stoichiometry: 1.0
species: 764636
type: SpeciesReference

359018
stoichiometry: 1.0
species: 767656
type: SpeciesReference

361834
stoichiometry: 1.0
species: 768736
type: SpeciesReference

831124
units: 344978
value: 6.8E-18
type: LocalParameter

776695
kinetic law: 362101
product: 362089
reactant: 362076
reactant: 362064
fast: false
reversible: true
type: Reaction

347615
local parameters: 830277
local parameters: 830274
notes: kf*Ca_control_PSD-kb*Ca_minus_PSD
type: KineticLaw

831634
units: 345062
value: 2.011824E-17
type: LocalParameter

360288
stoichiometry: 1.0
species: 767376
type: SpeciesReference

347555
stoichiometry: 1.0
species: 768936
type: SpeciesReference

346786
local parameters: 830163
local parameters: 830160
notes: kf*CaM_minus_Ca4_minus_PSD-kb*CaM_minus_Ca4
type: KineticLaw

352233
stoichiometry: 1.0
species: 766296
type: SpeciesReference

354587
stoichiometry: 1.0
species: 768716
type: SpeciesReference

346423
local parameters: 830115
local parameters: 830112
notes: kf*cAMP-kb*AC_slash_cAMP_in_dend
type: KineticLaw

774356
kinetic law: 355886
product: 355874
reactant: 355862
reactant: 355850
fast: false
reversible: true
type: Reaction

354843
stoichiometry: 1.0
species: 768576
type: SpeciesReference

830724
units: 345062
value: 3.0779838E-18
type: LocalParameter

771896
kinetic law: 349770
product: 349758
reactant: 349746
reactant: 349734
fast: false
reversible: true
type: Reaction

348972
stoichiometry: 1.0
species: 763956
type: SpeciesReference

830106
units: 345062
value: 6.479838E-14
type: LocalParameter

831283
units: 345062
value: 4.99998E-18
type: LocalParameter

774355
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product: 355826
product: 355814
reactant: 355802
fast: false
reversible: false
type: Reaction

830766
units: 344978
value: 7.2E-15
type: LocalParameter

350036
stoichiometry: 1.0
species: 763956
type: SpeciesReference

768736
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 763776
type: Species

831520
units: 344978
value: 7.2E-16
type: LocalParameter

351199
stoichiometry: 1.0
species: 768756
type: SpeciesReference

345436
stoichiometry: 1.0
species: 764836
type: SpeciesReference

349758
stoichiometry: 1.0
species: 764216
type: SpeciesReference

353313
stoichiometry: 1.0
species: 769096
type: SpeciesReference

767016
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 763776
type: Species

831127
units: 344978
value: 1.7E-18
type: LocalParameter

348610
local parameters: 830376
local parameters: 830373
notes: k1*AMPAR_slash_A831_star__B*PKA_minus_active-k2*PKA_minus_active_slash_PKA_sbo_16_sbc__slash_PKA_sbo_16_sbc__cplx
type: KineticLaw

358484
stoichiometry: 1.0
species: 767156
type: SpeciesReference

776475
kinetic law: 361569
product: 361557
product: 361545
reactant: 361532
fast: false
reversible: false
type: Reaction

350979
stoichiometry: 1.0
species: 763956
type: SpeciesReference

830199
units: 345062
value: 0.0
type: LocalParameter

774036
kinetic law: 354963
product: 354951
product: 354939
reactant: 354927
fast: false
reversible: false
type: Reaction

831232
units: 344978
value: 1.4E-17
type: LocalParameter

358825
stoichiometry: 1.0
species: 764936
type: SpeciesReference

831673
units: 344978
value: 2.403E-16
type: LocalParameter

358544
local parameters: 831298
notes: k3*PKC_minus_active_slash_PKC_minus_phosph_minus_neurogranin_slash_PKC_minus_phosph_minus_neurogranin_cplx
type: KineticLaw

831271
units: 344978
value: 3.5E-18
type: LocalParameter

773876
kinetic law: 354575
product: 354563
product: 354551
reactant: 354539
fast: false
reversible: false
type: Reaction

829983
units: 344978
value: 9.0E-17
type: LocalParameter

357796
stoichiometry: 1.0
species: 766376
type: SpeciesReference

359961
stoichiometry: 1.0
species: 767856
type: SpeciesReference

357302
stoichiometry: 1.0
species: 768796
type: SpeciesReference

831631
units: 344978
value: 1.8E-16
type: LocalParameter

346955
stoichiometry: 1.0
species: 767276
type: SpeciesReference

361942
stoichiometry: 1.0
species: 767636
type: SpeciesReference

764916
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boundary condition: false
has only substance units: false
initial concentration: 10.0
initial amount: NaN
in compartment: 763776
type: Species

347507
stoichiometry: 1.0
species: 765756
type: SpeciesReference

830971
units: 344978
value: 8.0E-18
type: LocalParameter

830217
units: 344978
value: 0.0
type: LocalParameter

831568
units: 344978
value: 1.8E-16
type: LocalParameter

360831
stoichiometry: 1.0
species: 768036
type: SpeciesReference

353361
stoichiometry: 1.0
species: 765976
type: SpeciesReference

830835
units: 345062
value: 2.77776E-19
type: LocalParameter

831454
units: 345062
value: 1.8106416E-16
type: LocalParameter

768116
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 763757
type: Species

345087
exponent: -1.0
scale: -6
multipler: 1.0
kind: MOLE
type: SBMLUnit

354394
stoichiometry: 1.0
species: 768556
type: SpeciesReference

764476
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 763757
type: Species

360191
stoichiometry: 1.0
species: 767556
type: SpeciesReference

348283
stoichiometry: 1.0
species: 764996
type: SpeciesReference

358556
stoichiometry: 1.0
species: 764816
type: SpeciesReference

350108
local parameters: 830514
notes: k3*PKA_minus_active_slash_PKA_slash_PKA_cplx
type: KineticLaw

345375
local parameters: 829977
local parameters: 829974
notes: kf*CaM_minus_TR2_minus_Ca2*Ca-kb*CaM_minus_Ca3
type: KineticLaw

765516
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boundary condition: false
has only substance units: false
initial concentration: 0.0740740740740741
initial amount: NaN
in compartment: 763757
type: Species

830265
units: 345062
value: 0.0
type: LocalParameter

830373
units: 345062
value: 3.5998992E-16
type: LocalParameter

346387
local parameters: 830109
local parameters: 830106
notes: kf*AC_slash_PDE1*CaM_minus_Ca4-kb*AC_slash_CaM_dot_PDE1
type: KineticLaw

768156
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boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 763757
type: Species

351942
stoichiometry: 1.0
species: 764636
type: SpeciesReference

350639
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species: 764396
type: SpeciesReference

356941
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species: 766816
type: SpeciesReference

348923
stoichiometry: 1.0
species: 767376
type: SpeciesReference

772756
kinetic law: 351870
product: 351858
product: 351846
reactant: 351834
fast: false
reversible: false
type: Reaction

771736
kinetic law: 349382
product: 349370
reactant: 349358
reactant: 349346
fast: false
reversible: true
type: Reaction

347231
local parameters: 830223
local parameters: 830220
notes: kf*AMPAR_slash_A845_star__B831_star_845_star_-kb*AMPAR_slash_AMPAR_deg
type: KineticLaw

361315
stoichiometry: 1.0
species: 768136
type: SpeciesReference

350820
stoichiometry: 1.0
species: 763956
type: SpeciesReference

357241
local parameters: 831178
local parameters: 831175
notes: k1*AMPAR_memb_slash_A_B831_star_845_star_*PP1_minus_active_PSD-k2*PP1_minus_active_PSD_slash_PP1_sbo_20_sbc__slash_PP1_sbo_20_sbc__cplx
type: KineticLaw

830871
units: 345062
value: 2.77776E-19
type: LocalParameter

358617
stoichiometry: 1.0
species: 764796
type: SpeciesReference

360492
stoichiometry: 1.0
species: 767636
type: SpeciesReference

769176
constant: false
boundary condition: false
has only substance units: false
initial concentration: 22.0
initial amount: NaN
in compartment: 763757
type: Species

349478
local parameters: 830457
local parameters: 830454
notes: k1*AMPAR_slash_A_B831_star_845_star_*PKA_minus_active-k2*PKA_minus_active_slash_PKA_sbo_26_sbc__slash_PKA_sbo_26_sbc__cplx
type: KineticLaw

357978
stoichiometry: 1.0
species: 768816
type: SpeciesReference

830268
units: 344978
value: 2.25E-16
type: LocalParameter

347447
local parameters: 830253
local parameters: 830250
notes: kf*AMPAR_slash_A831_star_845_star__B845_star_*Anchor-kb*AMPAR_memb_slash_A831_star_845_star__B845_star_
type: KineticLaw

775395
kinetic law: 358958
product: 358946
product: 358934
product: 358922
reactant: 358910
fast: false
reversible: false
type: Reaction

773076
kinetic law: 352646
modifier: 352634
product: 352621
reactant: 352609
notes: Reduced Km to match expt data for basal activation of AC2 by PKC. Now k1 = 2.9e-6, k2 = 72, k3 = 18 18 Feb: Raised Km to 300 based on BRENDA data. Unlikely to make much difference, given the vast amount of ATP.
fast: false
reversible: false
type: Reaction

775415
kinetic law: 359006
product: 358994
reactant: 358982
reactant: 358970
notes: From Seki et al ABB 316(2):673-679
fast: false
reversible: true
type: Reaction

830370
units: 344978
value: 5.4E-16
type: LocalParameter

348863
stoichiometry: 1.0
species: 767296
type: SpeciesReference

776075
kinetic law: 360601
product: 360589
product: 360577
reactant: 360565
fast: false
reversible: false
type: Reaction

353878
stoichiometry: 1.0
species: 768736
type: SpeciesReference

771196
kinetic law: 348077
product: 348065
product: 348053
reactant: 348040
fast: false
reversible: false
type: Reaction

354058
stoichiometry: 1.0
species: 766116
type: SpeciesReference

775495
kinetic law: 359199
product: 359187
reactant: 359175
reactant: 359163
fast: false
reversible: true
type: Reaction

768056
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 763757
type: Species

771116
kinetic law: 347881
product: 347869
product: 347857
reactant: 347845
fast: false
reversible: false
type: Reaction

831565
units: 344978
value: 7.2E-16
type: LocalParameter

360300
stoichiometry: 1.0
species: 767636
type: SpeciesReference

767376
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 763757
type: Species

764436
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 763757
type: Species

763796
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 763757
type: Species

355473
stoichiometry: 1.0
species: 766376
type: SpeciesReference

830874
units: 344978
value: 2.0E-17
type: LocalParameter

774096
kinetic law: 355108
product: 355096
reactant: 355084
reactant: 355072
fast: false
reversible: true
type: Reaction

357833
stoichiometry: 1.0
species: 766996
type: SpeciesReference

764236
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 763757
type: Species

346895
stoichiometry: 1.0
species: 764956
type: SpeciesReference

350146
stoichiometry: 1.0
species: 764296
type: SpeciesReference

775455
kinetic law: 359102
product: 359090
reactant: 359078
reactant: 359066
fast: false
reversible: true
type: Reaction

830214
units: 344978
value: 3.24E-21
type: LocalParameter

830598
units: 345062
value: 3.999888E-17
type: LocalParameter

351749
stoichiometry: 1.0
species: 764636
type: SpeciesReference

359271
stoichiometry: 1.0
species: 767636
type: SpeciesReference

766896
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 763776
type: Species

350072
stoichiometry: 1.0
species: 764276
type: SpeciesReference

830109
units: 344978
value: 4.5E-16
type: LocalParameter

768096
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 763757
type: Species

358593
local parameters: 831304
local parameters: 831301
notes: k1*CaM_slash_neurogranin_minus_CaM*PKC_minus_active-k2*PKC_minus_active_slash_PKC_minus_phosph_minus_ng_minus_CaM_slash_PKC_minus_phosph_minus_ng_minus_CaM_cplx
type: KineticLaw

831451
units: 344978
value: 1.8E-16
type: LocalParameter

356881
stoichiometry: 1.0
species: 768756
type: SpeciesReference

830832
units: 344978
value: 5.0E-18
type: LocalParameter

354951
stoichiometry: 1.0
species: 766376
type: SpeciesReference

359235
stoichiometry: 1.0
species: 767636
type: SpeciesReference

358653
local parameters: 831307
notes: k3*PKC_minus_active_slash_PKC_minus_phosph_minus_ng_minus_CaM_slash_PKC_minus_phosph_minus_ng_minus_CaM_cplx
type: KineticLaw

831526
units: 345062
value: 2.011824E-17
type: LocalParameter

357109
stoichiometry: 1.0
species: 768636
type: SpeciesReference

357410
stoichiometry: 1.0
species: 766376
type: SpeciesReference

763797
constant: false
boundary condition: false
has only substance units: false
initial concentration: 1.8
initial amount: NaN
in compartment: 763757
type: Species

830760
units: 344978
value: 9.0E-16
type: LocalParameter

776035
kinetic law: 360504
product: 360492
product: 360480
reactant: 360468
fast: false
reversible: false
type: Reaction

349927
stoichiometry: 1.0
species: 767576
type: SpeciesReference

361388
stoichiometry: 1.0
species: 768776
type: SpeciesReference

354697
stoichiometry: 1.0
species: 769136
type: SpeciesReference

360396
stoichiometry: 1.0
species: 767636
type: SpeciesReference

345327
local parameters: 829971
local parameters: 829968
notes: kf*CaM_slash_CaM*Ca^2-kb*CaM_minus_TR2_minus_Ca2
type: KineticLaw

770601
kinetic law: 346750
product: 346738
reactant: 346726
fast: false
reversible: true
type: Reaction

348391
stoichiometry: 1.0
species: 763956
type: SpeciesReference

349189
local parameters: 830430
local parameters: 830427
notes: k1*AMPAR_slash_A831_star__B831_star_*PKA_minus_active-k2*PKA_minus_active_slash_PKA_sbo_23_sbc__slash_PKA_sbo_23_sbc__cplx
type: KineticLaw

357398
stoichiometry: 1.0
species: 768676
type: SpeciesReference

766296
constant: false
boundary condition: false
has only substance units: false
initial concentration: 8.0
initial amount: NaN
in compartment: 763776
type: Species

354648
stoichiometry: 1.0
species: 768756
type: SpeciesReference

831289
units: 344978
value: 2.0E-18
type: LocalParameter

346099
stoichiometry: 1.0
species: 763956
type: SpeciesReference

830877
units: 344978
value: 5.0E-18
type: LocalParameter

830376
units: 344978
value: 2.16E-15
type: LocalParameter

830262
units: 344978
value: 5.0E-17
type: LocalParameter

356629
stoichiometry: 1.0
species: 768736
type: SpeciesReference

350748
local parameters: 830574
local parameters: 830571
notes: k1*AMPAR_memb_slash_A831_star__B*PKA_minus_active-k2*PKA_minus_active_slash_PKA_sbo_7_sbc__slash_PKA_sbo_7_sbc__cplx
type: KineticLaw

769296
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 763776
type: Species

361653
stoichiometry: 1.0
species: 767636
type: SpeciesReference

348500
stoichiometry: 1.0
species: 764017
type: SpeciesReference

353986
stoichiometry: 1.0
species: 769136
type: SpeciesReference

766936
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 763776
type: Species

830505
units: 344978
value: 5.4E-16
type: LocalParameter

776155
kinetic law: 360795
product: 360783
product: 360771
reactant: 360759
fast: false
reversible: false
type: Reaction

355362
stoichiometry: 1.0
species: 768696
type: SpeciesReference

765436
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 763757
type: Species

348331
stoichiometry: 1.0
species: 763996
type: SpeciesReference

352805
stoichiometry: 1.0
species: 765616
type: SpeciesReference

764996
constant: false
boundary condition: false
has only substance units: false
initial concentration: 1.8
initial amount: NaN
in compartment: 763757
type: Species

353614
local parameters: 830841
notes: k3*actCaMKII_minus_PSD_slash_CaMKII_sbo_2_sbc__slash_CaMKII_sbo_2_sbc__cplx
type: KineticLaw

346015
stoichiometry: 1.0
species: 765336
type: SpeciesReference

362441
local parameters: 831658
notes: k3*CaM_Ca_n_minus_CaNAB_slash_PP2B_sbo_14_sbc__slash_PP2B_sbo_14_sbc__cplx
type: KineticLaw

359343
local parameters: 831370
notes: k3*CaM_Ca_n_minus_CaNAB_slash_dephosph_inhib1_PSD_slash_dephosph_inhib1_PSD_cplx
type: KineticLaw

831277
units: 344978
value: 1.4E-17
type: LocalParameter

829989
units: 344978
value: 0.0
type: LocalParameter

347387
stoichiometry: 1.0
species: 768796
type: SpeciesReference

351247
stoichiometry: 1.0
species: 764516
type: SpeciesReference

355850
stoichiometry: 1.0
species: 768716
type: SpeciesReference

830838
units: 344978
value: 2.0E-17
type: LocalParameter

770696
kinetic law: 346967
product: 346955
reactant: 346943
fast: false
reversible: true
type: Reaction

356091
stoichiometry: 1.0
species: 766636
type: SpeciesReference

830211
units: 345062
value: 0.0
type: LocalParameter

355959
stoichiometry: 1.0
species: 766376
type: SpeciesReference

358714
stoichiometry: 1.0
species: 767196
type: SpeciesReference

769216
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 763757
type: Species

776875
kinetic law: 362537
product: 362525
product: 362513
reactant: 362501
fast: false
reversible: false
type: Reaction

353022
stoichiometry: 1.0
species: 765676
type: SpeciesReference

356295
stoichiometry: 1.0
species: 768596
type: SpeciesReference

352451
local parameters: 830730
notes: k3*CaNAB_minus_Ca4_slash_dephosph_inhib1_noCaM_slash_dephosph_inhib1_noCaM_cplx
type: KineticLaw

359755
stoichiometry: 1.0
species: 767636
type: SpeciesReference

347761
stoichiometry: 1.0
species: 764616
type: SpeciesReference

763816
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 763757
type: Species

346991
stoichiometry: 1.0
species: 767556
type: SpeciesReference

350931
stoichiometry: 1.0
species: 764456
type: SpeciesReference

830151
units: 344978
value: 1.0E-18
type: LocalParameter

773316
kinetic law: 353227
product: 353214
product: 353202
reactant: 353190
fast: false
reversible: false
type: Reaction

349891
stoichiometry: 1.0
species: 767436
type: SpeciesReference

357639
stoichiometry: 1.0
species: 766956
type: SpeciesReference

355326
stoichiometry: 1.0
species: 768656
type: SpeciesReference

766216
constant: false
boundary condition: false
has only substance units: false
initial concentration: 4.06666666666667E-215
initial amount: NaN
in compartment: 763776
type: Species

765476
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0740740740740741
initial amount: NaN
in compartment: 763757
type: Species

353070
stoichiometry: 1.0
species: 765836
type: SpeciesReference

831529
units: 344978
value: 7.2E-16
type: LocalParameter

830974
units: 344978
value: 2.0E-18
type: LocalParameter

765116
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.00691
initial amount: NaN
in compartment: 763757
type: Species

772576
kinetic law: 351430
product: 351418
reactant: 351406
reactant: 351394
fast: false
reversible: true
type: Reaction

356557
stoichiometry: 1.0
species: 766736
type: SpeciesReference

352052
stoichiometry: 1.0
species: 765076
type: SpeciesReference

352878
stoichiometry: 1.0
species: 765656
type: SpeciesReference

356332
stoichiometry: 1.0
species: 768536
type: SpeciesReference

770916
kinetic law: 347447
product: 347435
reactant: 347423
reactant: 347411
fast: false
reversible: true
type: Reaction

351882
stoichiometry: 1.0
species: 764616
type: SpeciesReference

770316
kinetic law: 346123
product: 346111
product: 346099
reactant: 346087
notes: This has to be fast, as the activation of PKA by cAMP is also fast. kf was 10
fast: false
reversible: true
type: Reaction

772536
kinetic law: 351333
product: 351321
reactant: 351309
reactant: 351297
fast: false
reversible: true
type: Reaction

352305
local parameters: 830718
local parameters: 830715
notes: k1*PP1_PSD_slash_PP1_minus_I1_star_*PP2A-k2*PP2A_slash_PP2A_minus_dephosph_minus_PP1_minus_I_star__PSD_slash_PP2A_minus_dephosph_minus_PP1_minus_I_star__PSD_cplx
type: KineticLaw

353722
stoichiometry: 1.0
species: 768696
type: SpeciesReference

362173
stoichiometry: 1.0
species: 767636
type: SpeciesReference

773696
kinetic law: 354142
product: 354130
reactant: 354118
reactant: 354106
fast: false
reversible: true
type: Reaction

358339
stoichiometry: 1.0
species: 766376
type: SpeciesReference

351834
stoichiometry: 1.0
species: 764736
type: SpeciesReference

830508
units: 345062
value: 3.999888E-17
type: LocalParameter

358267
stoichiometry: 1.0
species: 768576
type: SpeciesReference

349587
stoichiometry: 1.0
species: 764177
type: SpeciesReference

345642
stoichiometry: 1.0
species: 764896
type: SpeciesReference

354794
stoichiometry: 1.0
species: 769136
type: SpeciesReference

360528
stoichiometry: 1.0
species: 767636
type: SpeciesReference

361025
stoichiometry: 1.0
species: 768076
type: SpeciesReference

351151
stoichiometry: 1.0
species: 764496
type: SpeciesReference

774955
kinetic law: 357869
product: 357857
product: 357845
reactant: 357833
fast: false
reversible: false
type: Reaction

770016
kinetic law: 345424
product: 345412
reactant: 345400
reactant: 345388
notes: Surprisingly, no direct info on rates from neurogranin at this time. These rates are based on GAP-43 binding studies. As GAP-43 and neurogranin share near identity in the CaM/PKC binding regions, and also similarity in phosph and dephosph rates, I am borrowing GAP-43 kinetic info. See Alexander et al JBC 262:13 6108-6113 1987
fast: false
reversible: true
type: Reaction

353506
stoichiometry: 1.0
species: 769136
type: SpeciesReference

830433
units: 344978
value: 5.4E-16
type: LocalParameter

354274
stoichiometry: 1.0
species: 769136
type: SpeciesReference

830502
units: 344978
value: 2.16E-15
type: LocalParameter

362910
stoichiometry: 1.0
species: 769456
type: SpeciesReference

348658
local parameters: 830379
notes: k3*PKA_minus_active_slash_PKA_sbo_16_sbc__slash_PKA_sbo_16_sbc__cplx
type: KineticLaw

349298
stoichiometry: 1.0
species: 764136
type: SpeciesReference

353686
stoichiometry: 1.0
species: 768536
type: SpeciesReference

764016
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 763757
type: Species

772316
kinetic law: 350796
product: 350784
product: 350772
reactant: 350760
fast: false
reversible: false
type: Reaction

764376
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 763757
type: Species

775235
kinetic law: 358544
product: 358532
product: 358520
reactant: 358508
fast: false
reversible: false
type: Reaction

350784
stoichiometry: 1.0
species: 763956
type: SpeciesReference

831499
units: 345062
value: 1.8106416E-16
type: LocalParameter

768656
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 763776
type: Species

359066
stoichiometry: 1.0
species: 765016
type: SpeciesReference

357193
local parameters: 831172
notes: k3*PP1_minus_active_PSD_slash_PP1_sbo_19_sbc__slash_PP1_sbo_19_sbc__cplx
type: KineticLaw

351529
local parameters: 830646
local parameters: 830643
notes: k1*AMPAR_memb_slash_A831_star__B831_star_*PKA_minus_active-k2*PKA_minus_active_slash_PKA_sbo_15_sbc__slash_PKA_sbo_15_sbc__cplx
type: KineticLaw

764816
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 763757
type: Species

346063
stoichiometry: 1.0
species: 765356
type: SpeciesReference

831571
units: 345062
value: 2.011824E-17
type: LocalParameter

830220
units: 344978
value: 3.24E-21
type: LocalParameter

362778
local parameters: 831691
local parameters: 831688
notes: k1*CaMKII_minus_CaM_minus_PSD*tot_minus_CaM_minus_CaMKII_minus_PSD-k2*tot_minus_CaM_minus_CaMKII_minus_PSD_slash_CaM_minus_act_minus_286_minus_PSD_slash_CaM_minus_act_minus_286_minus_PSD_cplx
type: KineticLaw

357037
stoichiometry: 1.0
species: 766836
type: SpeciesReference

352390
stoichiometry: 1.0
species: 765196
type: SpeciesReference

362405
stoichiometry: 1.0
species: 768356
type: SpeciesReference

361532
stoichiometry: 1.0
species: 768176
type: SpeciesReference

765696
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 763757
type: Species

830541
units: 344978
value: 5.4E-16
type: LocalParameter

350218
stoichiometry: 1.0
species: 768516
type: SpeciesReference

359853
stoichiometry: 1.0
species: 767636
type: SpeciesReference

766536
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 763776
type: Species

347591
stoichiometry: 1.0
species: 768976
type: SpeciesReference

776555
kinetic law: 361762
product: 361750
product: 361738
reactant: 361726
fast: false
reversible: false
type: Reaction

359793
stoichiometry: 1.0
species: 767816
type: SpeciesReference

347725
stoichiometry: 1.0
species: 763816
type: SpeciesReference

830655
units: 344978
value: 2.16E-15
type: LocalParameter

770056
kinetic law: 345509
product: 345497
reactant: 345485
reactant: 345473
notes: Lets use the fast rate consts here. Since the rates are so different, I am not sure whether the order is relevant. These correspond to the TR2C fragment. We use the Martin et al rates here, plus the Drabicowski binding consts. All are scaled by 3X to cell temp. kf = 2e-10 kb = 72 Stemmer & Klee: K1=.9, K2=1.1. Assume 1.0uM for both. kb/kf=3.6e11. If kb=72, kf = 2e-10 (Exactly the same !)....
fast: false
reversible: true
type: Reaction

360795
local parameters: 831505
notes: k3*CaM_Ca_n_minus_CaNAB_slash_PP2B_sbo_30_sbc__slash_PP2B_sbo_30_sbc__cplx
type: KineticLaw

356043
stoichiometry: 1.0
species: 768776
type: SpeciesReference

355802
stoichiometry: 1.0
species: 766576
type: SpeciesReference

768996
constant: true
boundary condition: true
has only substance units: false
initial concentration: 2.0
initial amount: NaN
in compartment: 763776
type: Species

359925
local parameters: 831424
notes: k3*CaM_Ca_n_minus_CaNAB_slash_PP2B_sbo_21_sbc__slash_PP2B_sbo_21_sbc__cplx
type: KineticLaw

830977
units: 345062
value: 4.99998E-18
type: LocalParameter

766036
constant: false
boundary condition: false
has only substance units: false
initial concentration: 1.80016666666667E-215
initial amount: NaN
in compartment: 763776
type: Species

347015
local parameters: 830193
local parameters: 830190
notes: kf*AMPAR_memb_slash_A831_star__B831_star_-kb*AMPAR_slash_A831_star__B831_star_*Anchor
type: KineticLaw

362331
stoichiometry: 1.0
species: 767636
type: SpeciesReference

358934
stoichiometry: 1.0
species: 764936
type: SpeciesReference

352353
local parameters: 830721
notes: k3*PP2A_slash_PP2A_minus_dephosph_minus_PP1_minus_I_star__PSD_slash_PP2A_minus_dephosph_minus_PP1_minus_I_star__PSD_cplx
type: KineticLaw

354479
local parameters: 830922
notes: k3*actCaMKII_minus_PSD_slash_CaMKII_sbo_11_sbc__slash_CaMKII_sbo_11_sbc__cplx
type: KineticLaw

352731
stoichiometry: 1.0
species: 765556
type: SpeciesReference

770476
kinetic law: 346472
product: 346460
reactant: 346448
reactant: 346436
fast: false
reversible: true
type: Reaction

346678
stoichiometry: 1.0
species: 765776
type: SpeciesReference

831409
units: 345062
value: 1.8106416E-16
type: LocalParameter

774396
kinetic law: 356079
product: 356067
reactant: 356055
reactant: 356043
fast: false
reversible: true
type: Reaction

776215
kinetic law: 360941
product: 360929
reactant: 360917
reactant: 360905
fast: false
reversible: true
type: Reaction

358074
stoichiometry: 1.0
species: 768756
type: SpeciesReference

349697
stoichiometry: 1.0
species: 767396
type: SpeciesReference

345798
stoichiometry: 1.0
species: 765236
type: SpeciesReference

765736
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 763776
type: Species

830367
units: 344978
value: 2.16E-15
type: LocalParameter

358038
stoichiometry: 1.0
species: 768776
type: SpeciesReference

356211
stoichiometry: 1.0
species: 766376
type: SpeciesReference

347051
stoichiometry: 1.0
species: 768436
type: SpeciesReference

830938
units: 344978
value: 5.0E-18
type: LocalParameter

356151
stoichiometry: 1.0
species: 766376
type: SpeciesReference

770096
kinetic law: 345606
product: 345594
reactant: 345581
reactant: 345569
notes: Use K3 = 21.5 uM here from Stemmer and Klee table 3. kb/kf =21.5 * 6e5 so kf = 7.75e-7, kb = 10
fast: false
reversible: true
type: Reaction

355242
stoichiometry: 1.0
species: 766376
type: SpeciesReference

356725
stoichiometry: 1.0
species: 768676
type: SpeciesReference

831448
units: 344978
value: 7.2E-16
type: LocalParameter

831388
units: 344978
value: 1.8E-16
type: LocalParameter

831022
units: 345062
value: 8.7498E-18
type: LocalParameter

768916
constant: true
boundary condition: true
has only substance units: false
initial concentration: 2.0
initial amount: NaN
in compartment: 763757
type: Species

774196
kinetic law: 355350
product: 355338
product: 355326
reactant: 355314
fast: false
reversible: false
type: Reaction

359454
stoichiometry: 1.0
species: 767336
type: SpeciesReference

351676
local parameters: 830658
notes: k3*CaMKII_slash_tot_CaM_CaMKII_slash_CaM_act_305_slash_CaM_act_305_cplx
type: KineticLaw

353130
local parameters: 830796
notes: k3*tot_minus_auto_minus_PSD_slash_auton_minus_305_minus_PSD_slash_auton_minus_305_minus_PSD_cplx
type: KineticLaw

358861
stoichiometry: 1.0
species: 764896
type: SpeciesReference

347664
stoichiometry: 1.0
species: 769016
type: SpeciesReference

352402
local parameters: 830727
local parameters: 830724
notes: k1*PP1_slash_I1_star_*CaNAB_minus_Ca4-k2*CaNAB_minus_Ca4_slash_dephosph_inhib1_noCaM_slash_dephosph_inhib1_noCaM_cplx
type: KineticLaw

350869
stoichiometry: 1.0
species: 768796
type: SpeciesReference

352160
local parameters: 830703
notes: k3*PP2A_slash_PP2A_minus_dephosph_minus_PP1_minus_I_star__slash_PP2A_minus_dephosph_minus_PP1_minus_I_star__cplx
type: KineticLaw

830544
units: 345062
value: 3.999888E-17
type: LocalParameter

345714
stoichiometry: 1.0
species: 763797
type: SpeciesReference

772676
kinetic law: 351676
product: 351664
product: 351651
reactant: 351639
fast: false
reversible: false
type: Reaction

766076
constant: false
boundary condition: false
has only substance units: false
initial concentration: 3.588E-215
initial amount: NaN
in compartment: 763776
type: Species

771556
kinetic law: 348948
product: 348935
product: 348923
reactant: 348911
fast: false
reversible: false
type: Reaction

360119
local parameters: 831442
notes: k3*CaM_Ca_n_minus_CaNAB_slash_PP2B_sbo_23_sbc__slash_PP2B_sbo_23_sbc__cplx
type: KineticLaw

764017
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 763757
type: Species

764616
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 763757
type: Species

775915
kinetic law: 360215
product: 360203
product: 360191
reactant: 360179
fast: false
reversible: false
type: Reaction

830328
units: 345062
value: 2.2062942E-16
type: LocalParameter

362271
stoichiometry: 1.0
species: 767636
type: SpeciesReference

362886
stoichiometry: 1.0
species: 768496
type: SpeciesReference

358970
stoichiometry: 1.0
species: 764836
type: SpeciesReference

772396
kinetic law: 350991
product: 350979
product: 350967
reactant: 350955
fast: false
reversible: false
type: Reaction

765816
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 763776
type: Species

349358
stoichiometry: 1.0
species: 763956
type: SpeciesReference

356833
stoichiometry: 1.0
species: 766376
type: SpeciesReference

768696
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 763776
type: Species

360759
stoichiometry: 1.0
species: 768016
type: SpeciesReference

347303
local parameters: 830235
local parameters: 830232
notes: kf*AMPAR_slash_A845_star__B845_star_-kb*AMPAR_slash_AMPAR_deg
type: KineticLaw

831574
units: 344978
value: 7.2E-16
type: LocalParameter

348586
stoichiometry: 1.0
species: 763956
type: SpeciesReference

349963
local parameters: 830502
local parameters: 830499
notes: k1*AMPAR_slash_A831_star_845_star__B831_star_*PKA_minus_active-k2*PKA_minus_active_slash_PKA_sbo_31_sbc__slash_PKA_sbo_31_sbc__cplx
type: KineticLaw

775295
kinetic law: 358702
product: 358689
reactant: 358677
reactant: 358665
notes: Phorbol esters have little effect on AC1 or on the Gs-stimulation of AC2. So in this model we are only dealing with the increase in basal activation of AC2 induced by PKC k1 = 1.66e-6 k2 = 16 k3 =4
fast: false
reversible: true
type: Reaction

831445
units: 345062
value: 1.8106416E-16
type: LocalParameter

767056
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 763776
type: Species

353578
stoichiometry: 1.0
species: 766016
type: SpeciesReference

361496
stoichiometry: 1.0
species: 767636
type: SpeciesReference

357290
local parameters: 831181
notes: k3*PP1_minus_active_PSD_slash_PP1_sbo_20_sbc__slash_PP1_sbo_20_sbc__cplx
type: KineticLaw

765896
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 763776
type: Species

830658
units: 344978
value: 5.4E-16
type: LocalParameter

766316
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 763776
type: Species

362802
stoichiometry: 1.0
species: 765736
type: SpeciesReference

830259
units: 344978
value: 8.0E-20
type: LocalParameter

362051
local parameters: 831622
notes: k3*CaM_Ca_n_minus_CaNAB_slash_PP2B_sbo_10_sbc__slash_PP2B_sbo_10_sbc__cplx
type: KineticLaw

360989
local parameters: 831523
notes: k3*CaM_Ca_n_minus_CaNAB_slash_PP2B_sbo_32_sbc__slash_PP2B_sbo_32_sbc__cplx
type: KineticLaw

359175
stoichiometry: 1.0
species: 767636
type: SpeciesReference

774395
kinetic law: 356031
product: 356019
product: 356007
reactant: 355995
fast: false
reversible: false
type: Reaction

770876
kinetic law: 347351
product: 347339
reactant: 347327
reactant: 347315
fast: false
reversible: true
type: Reaction

831406
units: 344978
value: 1.8E-16
type: LocalParameter

357566
stoichiometry: 1.0
species: 766376
type: SpeciesReference

362125
stoichiometry: 1.0
species: 768556
type: SpeciesReference

830430
units: 344978
value: 2.16E-15
type: LocalParameter

345473
stoichiometry: 1.0
species: 764876
type: SpeciesReference

830079
units: 345062
value: 1.6199838E-15
type: LocalParameter

351455
stoichiometry: 1.0
species: 768756
type: SpeciesReference

764176
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 763757
type: Species

346171
local parameters: 830079
local parameters: 830076
notes: kf*PKA_slash_R2C_minus_cAMP4-kb*PKA_minus_active*PKA_slash_R2_minus_cAMP4
type: KineticLaw

765856
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 763776
type: Species

359115
stoichiometry: 1.0
species: 767676
type: SpeciesReference

831496
units: 344978
value: 1.8E-16
type: LocalParameter

360456
local parameters: 831475
local parameters: 831472
notes: k1*AMPAR_slash_A845_star__B831_star_845_star_*CaM_Ca_n_minus_CaNAB-k2*CaM_Ca_n_minus_CaNAB_slash_PP2B_sbo_27_sbc__slash_PP2B_sbo_27_sbc__cplx
type: KineticLaw

361424
local parameters: 831565
local parameters: 831562
notes: k1*AMPAR_memb_slash_A831_star_845_star__B845_star_*CaM_Ca_n_minus_CaNAB-k2*CaM_Ca_n_minus_CaNAB_slash_PP2B_sbo_4_sbc__slash_PP2B_sbo_4_sbc__cplx
type: KineticLaw

771096
kinetic law: 347833
product: 347821
reactant: 347809
reactant: 347797
fast: false
reversible: true
type: Reaction

351713
stoichiometry: 1.0
species: 764716
type: SpeciesReference

362380
stoichiometry: 1.0
species: 768356
type: SpeciesReference

355583
stoichiometry: 1.0
species: 766536
type: SpeciesReference

357869
local parameters: 831235
notes: k3*PP1_minus_active_PSD_slash_PP1_sbo_26_sbc__slash_PP1_sbo_26_sbc__cplx
type: KineticLaw

362489
local parameters: 831664
local parameters: 831661
notes: k1*AMPAR_memb_slash_A831_star__B831_star_845_star_*CaM_Ca_n_minus_CaNAB-k2*CaM_Ca_n_minus_CaNAB_slash_PP2B_sbo_15_sbc__slash_PP2B_sbo_15_sbc__cplx
type: KineticLaw

358146
stoichiometry: 1.0
species: 766376
type: SpeciesReference

355898
stoichiometry: 1.0
species: 766596
type: SpeciesReference

764177
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 763757
type: Species

352559
stoichiometry: 1.0
species: 768856
type: SpeciesReference

MODEL9087255381
reaction: 770516
reaction: 773176
reaction: 775675
species: 767156
reaction: 776215
reaction: 772916
species: 768076
reaction: 773836
reaction: 770676
rule: 769596
reaction: 774355
reaction: 773856
reaction: 776435
species: 764776
reaction: 770696
species: 767176
reaction: 771456
reaction: 770796
reaction: 775515
species: 766496
species: 764536
species: 766196
species: 768436
species: 766156
reaction: 773116
species: 765016
species: 764296
reaction: 771176
species: 768636
reaction: 771476
reaction: 771016
species: 765836
reaction: 773496
reaction: 771696
reaction: 775635
reaction: 773756
is described by: http://identifiers.org/pubmed/16110334
reaction: 771776
reaction: 776955
species: 764216
compartment: 763777
reaction: 775155
species: 767016
reaction: 773296
reaction: 772696
reaction: 775175
reaction: 775435
reaction: 774935
species: 768596
species: 765176
species: 765356
reaction: 774436
reaction: 773776
species: 767776
reaction: 773316
species: 767496
reaction: 771376
species: 768396
species: 767296
reaction: 774236
reaction: 776595
species: 766016
reaction: 774276
species: 765116
reaction: 771856
species: 765896
species: 766916
species: 769316
species: 766216
species: 766996
reaction: 770236
species: 766736
reaction: 770436
species: 764016
rule: 769656
species: 768096
species: 768056
species: 766936
reaction: 774576
reaction: 771396

774316
kinetic law: 355694
product: 355682
reactant: 355670
reactant: 355658
fast: false
reversible: true
type: Reaction

354166
stoichiometry: 1.0
species: 768816
type: SpeciesReference

355206
local parameters: 830989
local parameters: 830986
notes: k1*CaMKII_star__star__star__minus_PSD*PP1_minus_active_PSD-k2*PP1_minus_active_PSD_slash_Deph_minus_thr286c_slash_Deph_minus_thr286c_cplx
type: KineticLaw

348960
stoichiometry: 1.0
species: 767316
type: SpeciesReference

348549
stoichiometry: 1.0
species: 763956
type: SpeciesReference

346810
stoichiometry: 1.0
species: 766296
type: SpeciesReference

776375
kinetic law: 361327
product: 361315
reactant: 361303
reactant: 361291
fast: false
reversible: true
type: Reaction

351566
stoichiometry: 1.0
species: 763956
type: SpeciesReference

357942
stoichiometry: 1.0
species: 768556
type: SpeciesReference

345002
exponent: -1.0
scale: 0
multipler: 1.0
kind: SECOND
type: SBMLUnit

346520
local parameters: 830127
local parameters: 830124
notes: kf*CaMKII_slash_CaMKII_minus_CaM*NMDAR-kb*CaMKII_minus_CaM_minus_PSD
type: KineticLaw

354915
local parameters: 830962
local parameters: 830959
notes: k1*CaMKII_minus_thr286_minus_CaM_minus_PSD*PP1_minus_active_PSD-k2*PP1_minus_active_PSD_slash_Deph_minus_thr286_slash_Deph_minus_thr286_cplx
type: KineticLaw

353240
stoichiometry: 1.0
species: 765796
type: SpeciesReference

354322
stoichiometry: 1.0
species: 766176
type: SpeciesReference

359817
stoichiometry: 1.0
species: 767636
type: SpeciesReference

348175
local parameters: 830334
notes: k3*PP1_minus_active_slash_Deph_minus_thr305a_slash_Deph_minus_thr305a_cplx
type: KineticLaw

354855
stoichiometry: 1.0
species: 769136
type: SpeciesReference

361726
stoichiometry: 1.0
species: 768216
type: SpeciesReference

356259
stoichiometry: 1.0
species: 766676
type: SpeciesReference

830932
units: 345062
value: 2.77776E-19
type: LocalParameter

361134
local parameters: 831538
local parameters: 831535
notes: k1*AMPAR_memb_slash_A845_star__B845_star_*CaM_Ca_n_minus_CaNAB-k2*CaM_Ca_n_minus_CaNAB_slash_PP2B_sbo_1_sbc__slash_PP2B_sbo_1_sbc__cplx
type: KineticLaw

767836
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 763757
type: Species

831601
units: 344978
value: 7.2E-16
type: LocalParameter

349855
stoichiometry: 1.0
species: 764236
type: SpeciesReference

773036
kinetic law: 352547
product: 352535
product: 352523
reactant: 352511
fast: false
reversible: false
type: Reaction

772816
kinetic law: 352016
product: 352004
reactant: 351992
reactant: 351980
notes: PP2A does most of the dephosph of I1 at basal Ca levels. See the review by Cohen in Ann Rev Biochem 1989. For now, lets halve Km. k1 was 3.3e-6, now 6.6e-6
fast: false
reversible: true
type: Reaction

355424
stoichiometry: 1.0
species: 768596
type: SpeciesReference

831028
units: 344978
value: 1.7E-18
type: LocalParameter

362730
local parameters: 831685
notes: k3*tot_minus_CaM_minus_CaMKII_minus_PSD_slash_CaM_minus_act_minus_305_minus_PSD_slash_CaM_minus_act_minus_305_minus_PSD_cplx
type: KineticLaw

351040
local parameters: 830601
local parameters: 830598
notes: k1*AMPAR_memb_slash_A_B831_star_*PKA_minus_active-k2*PKA_minus_active_slash_PKA_sbo_10_sbc__slash_PKA_sbo_10_sbc__cplx
type: KineticLaw

830076
units: 344978
value: 5.4E-15
type: LocalParameter

830721
units: 344978
value: 1.8E-16
type: LocalParameter

362015
stoichiometry: 1.0
species: 768276
type: SpeciesReference

773576
kinetic law: 353854
product: 353842
reactant: 353830
reactant: 353818
fast: false
reversible: true
type: Reaction

775815
kinetic law: 359973
product: 359961
reactant: 359949
reactant: 359937
fast: false
reversible: true
type: Reaction

345363
stoichiometry: 1.0
species: 764956
type: SpeciesReference

767236
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 763757
type: Species

831172
units: 344978
value: 1.7E-18
type: LocalParameter

831403
units: 344978
value: 7.2E-16
type: LocalParameter

349201
stoichiometry: 1.0
species: 764116
type: SpeciesReference

346702
stoichiometry: 1.0
species: 765736
type: SpeciesReference

771156
kinetic law: 347979
product: 347967
product: 347955
reactant: 347943
fast: false
reversible: false
type: Reaction

349250
stoichiometry: 1.0
species: 767376
type: SpeciesReference

773536
kinetic law: 353758
product: 353746
reactant: 353734
reactant: 353722
fast: false
reversible: true
type: Reaction

769136
constant: false
boundary condition: true
has only substance units: false
initial concentration: 2.0
initial amount: NaN
in compartment: 763776
type: Species

775855
kinetic law: 360071
product: 360058
reactant: 360045
reactant: 360033
fast: false
reversible: true
type: Reaction

831007
units: 344978
value: 6.8E-18
type: LocalParameter

831067
units: 345062
value: 8.7498E-18
type: LocalParameter

774575
kinetic law: 356761
product: 356749
reactant: 356737
reactant: 356725
fast: false
reversible: true
type: Reaction

359527
stoichiometry: 1.0
species: 767636
type: SpeciesReference

360565
stoichiometry: 1.0
species: 767976
type: SpeciesReference

355024
stoichiometry: 1.0
species: 766416
type: SpeciesReference

767276
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0925925925925926
initial amount: NaN
in compartment: 763757
type: Species

347519
stoichiometry: 1.0
species: 765936
type: SpeciesReference

361930
stoichiometry: 1.0
species: 768676
type: SpeciesReference

772856
kinetic law: 352112
product: 352100
reactant: 352088
reactant: 352076
notes: k1 changed from 3.3e-6 to 6.6e-6
fast: false
reversible: true
type: Reaction

348476
stoichiometry: 1.0
species: 767296
type: SpeciesReference

774576
kinetic law: 356809
product: 356797
product: 356785
reactant: 356773
fast: false
reversible: false
type: Reaction

346460
stoichiometry: 1.0
species: 765756
type: SpeciesReference

361870
stoichiometry: 1.0
species: 768796
type: SpeciesReference

351603
stoichiometry: 1.0
species: 769036
type: SpeciesReference

831118
units: 344978
value: 1.7E-18
type: LocalParameter

352621
stoichiometry: 1.0
species: 763916
type: SpeciesReference

831400
units: 345062
value: 1.8106416E-16
type: LocalParameter

830037
units: 344978
value: 9.0E-17
type: LocalParameter

767876
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 763757
type: Species

831340
units: 344978
value: 2.403E-16
type: LocalParameter

355170
stoichiometry: 1.0
species: 765816
type: SpeciesReference

831493
units: 344978
value: 7.2E-16
type: LocalParameter

763976
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 763757
type: Species

831280
units: 344978
value: 3.5E-18
type: LocalParameter

357675
local parameters: 831217
notes: k3*PP1_minus_active_PSD_slash_PP1_sbo_24_sbc__slash_PP1_sbo_24_sbc__cplx
type: KineticLaw

351418
stoichiometry: 1.0
species: 764556
type: SpeciesReference

356509
stoichiometry: 1.0
species: 766376
type: SpeciesReference

354807
stoichiometry: 1.0
species: 766276
type: SpeciesReference

345750
stoichiometry: 2.0
species: 763936
type: SpeciesReference

768896
constant: true
boundary condition: true
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 763757
type: Species

359707
stoichiometry: 1.0
species: 767516
type: SpeciesReference

357712
stoichiometry: 1.0
species: 766976
type: SpeciesReference

775015
kinetic law: 358014
product: 358002
reactant: 357990
reactant: 357978
fast: false
reversible: true
type: Reaction

345214
stoichiometry: 1.0
species: 764616
type: SpeciesReference

359392
local parameters: 831376
local parameters: 831373
notes: k1*PP1_PSD_slash_PP1_minus_I1_star_*CaM_Ca_n_minus_CaNAB-k2*CaM_Ca_n_minus_CaNAB_slash_dephosph_minus_PP1_minus_I_star__PSD_slash_dephosph_minus_PP1_minus_I_star__PSD_cplx
type: KineticLaw

356785
stoichiometry: 1.0
species: 768556
type: SpeciesReference

361073
stoichiometry: 1.0
species: 767636
type: SpeciesReference

358448
local parameters: 831289
notes: k3*PP1_minus_active_PSD_slash_Deph_minus_thr305a_slash_Deph_minus_thr305a_cplx
type: KineticLaw

348439
stoichiometry: 1.0
species: 766316
type: SpeciesReference

354746
stoichiometry: 1.0
species: 768636
type: SpeciesReference

361617
local parameters: 831583
local parameters: 831580
notes: k1*AMPAR_memb_slash_A831_star__B845_star_*CaM_Ca_n_minus_CaNAB-k2*CaM_Ca_n_minus_CaNAB_slash_PP2B_sbo_6_sbc__slash_PP2B_sbo_6_sbc__cplx
type: KineticLaw

765276
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.5
initial amount: NaN
in compartment: 763757
type: Species

829992
units: 345014
value: 7.2E-16
type: LocalParameter

347991
stoichiometry: 1.0
species: 764656
type: SpeciesReference

346123
local parameters: 830073
local parameters: 830070
notes: kf*PKA_slash_R2C2_minus_cAMP4-kb*PKA_minus_active*PKA_slash_R2C_minus_cAMP4
type: KineticLaw

830409
units: 345062
value: 3.5998992E-16
type: LocalParameter

354430
local parameters: 830919
local parameters: 830916
notes: k1*AMPAR_memb_slash_A_B831_star_*actCaMKII_minus_PSD-k2*actCaMKII_minus_PSD_slash_CaMKII_sbo_11_sbc__slash_CaMKII_sbo_11_sbc__cplx
type: KineticLaw

831175
units: 345062
value: 8.7498E-18
type: LocalParameter

831682
units: 344978
value: 2.4E-16
type: LocalParameter

347099
stoichiometry: 1.0
species: 768436
type: SpeciesReference

356199
stoichiometry: 1.0
species: 768656
type: SpeciesReference

360143
stoichiometry: 1.0
species: 767636
type: SpeciesReference

831004
units: 345062
value: 8.7498E-18
type: LocalParameter

351259
stoichiometry: 1.0
species: 768816
type: SpeciesReference

830325
units: 344978
value: 2.25E-16
type: LocalParameter

360941
local parameters: 831520
local parameters: 831517
notes: k1*AMPAR_slash_A835_star_845_star__B835_star_845_star_*CaM_Ca_n_minus_CaNAB-k2*CaM_Ca_n_minus_CaNAB_slash_PP2B_sbo_32_sbc__slash_PP2B_sbo_32_sbc__cplx
type: KineticLaw

361279
local parameters: 831550
notes: k3*CaM_Ca_n_minus_CaNAB_slash_PP2B_sbo_2_sbc__slash_PP2B_sbo_2_sbc__cplx
type: KineticLaw

347483
stoichiometry: 1.0
species: 768696
type: SpeciesReference

773656
kinetic law: 354046
product: 354034
reactant: 354022
reactant: 354010
fast: false
reversible: true
type: Reaction

345822
stoichiometry: 1.0
species: 765256
type: SpeciesReference

766976
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 763776
type: Species

347833
local parameters: 830304
local parameters: 830301
notes: k1*CaMKII_slash_CaMKII_minus_thr286*PP1_minus_active-k2*PP1_minus_active_slash_Deph_minus_thr286b_slash_Deph_minus_thr286b_cplx
type: KineticLaw

774995
kinetic law: 357966
product: 357954
product: 357942
reactant: 357929
fast: false
reversible: false
type: Reaction

356446
stoichiometry: 1.0
species: 766376
type: SpeciesReference

830031
units: 344978
value: 9.0E-17
type: LocalParameter

348235
stoichiometry: 1.0
species: 763976
type: SpeciesReference

359683
local parameters: 831403
local parameters: 831400
notes: k1*AMPAR_slash_A845_star__B831_star_*CaM_Ca_n_minus_CaNAB-k2*CaM_Ca_n_minus_CaNAB_slash_PP2B_sbo_19_sbc__slash_PP2B_sbo_19_sbc__cplx
type: KineticLaw

769256
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 763757
type: Species

831064
units: 344978
value: 1.7E-18
type: LocalParameter

358751
local parameters: 831316
notes: k3*PKC_minus_active_slash_phosph_minus_AC2_slash_phosph_minus_AC2_cplx
type: KineticLaw

831001
units: 344978
value: 1.7E-18
type: LocalParameter

362622
stoichiometry: 1.0
species: 767636
type: SpeciesReference

350328
stoichiometry: 1.0
species: 763956
type: SpeciesReference

772176
kinetic law: 350458
product: 350445
reactant: 350432
reactant: 350419
fast: false
reversible: true
type: Reaction

767536
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 763757
type: Species

356407
stoichiometry: 1.0
species: 766376
type: SpeciesReference

776255
kinetic law: 361037
product: 361025
reactant: 361013
reactant: 361001
fast: false
reversible: true
type: Reaction

830439
units: 344978
value: 2.16E-15
type: LocalParameter

349310
stoichiometry: 1.0
species: 767396
type: SpeciesReference

831604
units: 344978
value: 1.8E-16
type: LocalParameter

831226
units: 344978
value: 3.5E-18
type: LocalParameter

360686
stoichiometry: 1.0
species: 767636
type: SpeciesReference

831343
units: 344978
value: 6.03E-17
type: LocalParameter

830935
units: 344978
value: 2.0E-17
type: LocalParameter

362694
stoichiometry: 1.0
species: 768456
type: SpeciesReference

348766
stoichiometry: 1.0
species: 767556
type: SpeciesReference

831382
units: 345062
value: 1.8106416E-16
type: LocalParameter

349539
stoichiometry: 1.0
species: 767496
type: SpeciesReference

830478
units: 344978
value: 5.4E-16
type: LocalParameter

767916
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 763757
type: Species

353530
stoichiometry: 1.0
species: 768596
type: SpeciesReference

771296
kinetic law: 348319
product: 348307
reactant: 348295
reactant: 348283
notes: #s from Bramson et al CRC crit rev Biochem 15:2 93-124. They have a huge list of peptide substrates and I have chosen high-ish rates. These consts give too much PKA activity, so lower Vmax 1/3. Now, k1 = 3e-5, k2 = 36, k3 = 9 (still pretty fast). Also lower Km 1/3 so k1 = 1e-5 Cohen et al FEBS Lett 76:182-86 1977 say rate =30% PKA act on phosphokinase beta.
fast: false
reversible: true
type: Reaction

776595
kinetic law: 361858
product: 361846
product: 361834
reactant: 361822
fast: false
reversible: false
type: Reaction

830610
units: 344978
value: 2.16E-15
type: LocalParameter

356485
stoichiometry: 1.0
species: 766716
type: SpeciesReference

830436
units: 345062
value: 3.5998992E-16
type: LocalParameter

350579
stoichiometry: 1.0
species: 768776
type: SpeciesReference

831229
units: 345062
value: 8.7498E-18
type: LocalParameter

346858
stoichiometry: 1.0
species: 766376
type: SpeciesReference

830547
units: 344978
value: 2.16E-15
type: LocalParameter

768616
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 763776
type: Species

353289
stoichiometry: 1.0
species: 765876
type: SpeciesReference

359743
stoichiometry: 1.0
species: 767576
type: SpeciesReference

360083
stoichiometry: 1.0
species: 767876
type: SpeciesReference

359416
stoichiometry: 1.0
species: 766356
type: SpeciesReference

765376
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 763757
type: Species

776835
kinetic law: 362441
product: 362429
product: 362417
reactant: 362405
fast: false
reversible: false
type: Reaction

830613
units: 344978
value: 5.4E-16
type: LocalParameter

356103
stoichiometry: 1.0
species: 768696
type: SpeciesReference

771956
kinetic law: 349915
product: 349903
product: 349891
reactant: 349879
fast: false
reversible: false
type: Reaction

771256
kinetic law: 348223
product: 348211
reactant: 348199
reactant: 348187
notes: Same rates as PKA-phosph-I1
fast: false
reversible: true
type: Reaction

831178
units: 344978
value: 1.4E-17
type: LocalParameter

356905
local parameters: 831145
notes: k3*PP1_minus_active_PSD_slash_PP1_sbo_16_sbc__slash_PP1_sbo_16_sbc__cplx
type: KineticLaw

830322
units: 344978
value: 9.0E-16
type: LocalParameter

831385
units: 344978
value: 7.2E-16
type: LocalParameter

357145
local parameters: 831169
local parameters: 831166
notes: k1*AMPAR_memb_slash_A831_star_845_star__B831_star_*PP1_minus_active_PSD-k2*PP1_minus_active_PSD_slash_PP1_sbo_19_sbc__slash_PP1_sbo_19_sbc__cplx
type: KineticLaw

831025
units: 344978
value: 6.8E-18
type: LocalParameter

776195
kinetic law: 360892
product: 360880
product: 360868
reactant: 360856
fast: false
reversible: false
type: Reaction

831490
units: 345062
value: 1.8106416E-16
type: LocalParameter

361182
local parameters: 831541
notes: k3*CaM_Ca_n_minus_CaNAB_slash_PP2B_sbo_1_sbc__slash_PP2B_sbo_1_sbc__cplx
type: KineticLaw

360033
stoichiometry: 1.0
species: 767476
type: SpeciesReference

771996
kinetic law: 350012
product: 349999
product: 349987
reactant: 349975
fast: false
reversible: false
type: Reaction

830034
units: 345014
value: 9.00720324E-13
type: LocalParameter

357085
stoichiometry: 1.0
species: 766376
type: SpeciesReference

771216
kinetic law: 348127
product: 348114
reactant: 348101
reactant: 348089
fast: false
reversible: true
type: Reaction

353470
local parameters: 830829
local parameters: 830826
notes: k1*AMPAR_memb_slash_A_B845_star_*actCaMKII_minus_PSD-k2*actCaMKII_minus_PSD_slash_CaMKII_sbo_1_sbc__slash_CaMKII_sbo_1_sbc__cplx
type: KineticLaw

350254
local parameters: 830529
local parameters: 830526
notes: k1*AMPAR_memb_slash_A_B*PKA_minus_active-k2*PKA_minus_active_slash_PKA_sbo_2_sbc__slash_PKA_sbo_2_sbc__cplx
type: KineticLaw

350367
stoichiometry: 1.0
species: 764336
type: SpeciesReference

830475
units: 344978
value: 2.16E-15
type: LocalParameter

346568
local parameters: 830133
local parameters: 830130
notes: kf*CaMKII_slash_CaMKII_minus_thr286_star__minus_CaM*NMDAR-kb*CaMKII_minus_thr286_minus_CaM_minus_PSD
type: KineticLaw

347773
stoichiometry: 1.0
species: 763797
type: SpeciesReference

348802
local parameters: 830394
local parameters: 830391
notes: k1*AMPAR_slash_A831_star__B831_star_*PKA_minus_active-k2*PKA_minus_active_slash_PKA_sbo_19_sbc__slash_PKA_sbo_19_sbc__cplx
type: KineticLaw

352463
stoichiometry: 1.0
species: 766316
type: SpeciesReference

830073
units: 345062
value: 1.6199838E-15
type: LocalParameter

830652
units: 345062
value: 1.1894364E-17
type: LocalParameter

830190
units: 344978
value: 8.0E-21
type: LocalParameter

352511
stoichiometry: 1.0
species: 765216
type: SpeciesReference

764316
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 763757
type: Species

351980
stoichiometry: 1.0
species: 765016
type: SpeciesReference

764696
constant: false
boundary condition: false
has only substance units: false
initial concentration: 6.3262962962963E-11
initial amount: NaN
in compartment: 763757
type: Species

770956
kinetic law: 347543
product: 347531
product: 347519
reactant: 347507
fast: false
reversible: true
type: Reaction

347123
stoichiometry: 1.0
species: 768516
type: SpeciesReference

351785
stoichiometry: 1.0
species: 764676
type: SpeciesReference

346279
stoichiometry: 1.0
species: 765496
type: SpeciesReference

347919
stoichiometry: 1.0
species: 763856
type: SpeciesReference

345581
stoichiometry: 1.0
species: 765956
type: SpeciesReference

768336
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 763757
type: Species

771056
kinetic law: 347737
product: 347725
reactant: 347713
reactant: 347701
fast: false
reversible: true
type: Reaction

831223
units: 344978
value: 1.4E-17
type: LocalParameter

830628
units: 344978
value: 2.16E-15
type: LocalParameter

347411
stoichiometry: 1.0
species: 767416
type: SpeciesReference

831073
units: 344978
value: 3.5E-18
type: LocalParameter

765636
constant: false
boundary condition: false
has only substance units: false
initial concentration: 2.59259259259259
initial amount: NaN
in compartment: 763757
type: Species

769456
constant: false
boundary condition: true
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 763776
type: Species

357518
stoichiometry: 1.0
species: 766936
type: SpeciesReference

346159
stoichiometry: 1.0
species: 765396
type: SpeciesReference

830739
units: 344978
value: 3.06E-18
type: LocalParameter

831325
units: 344978
value: 5.22E-17
type: LocalParameter

353914
stoichiometry: 1.0
species: 768596
type: SpeciesReference

348053
stoichiometry: 1.0
species: 764776
type: SpeciesReference

357929
stoichiometry: 1.0
species: 767016
type: SpeciesReference

771516
kinetic law: 348851
product: 348839
product: 348827
reactant: 348814
fast: false
reversible: false
type: Reaction

351346
stoichiometry: 1.0
species: 764536
type: SpeciesReference

765356
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 763757
type: Species

345545
stoichiometry: 1.0
species: 765916
type: SpeciesReference

774635
kinetic law: 357001
product: 356989
product: 356977
reactant: 356965
fast: false
reversible: false
type: Reaction

776795
kinetic law: 362343
product: 362331
product: 362319
reactant: 362307
fast: false
reversible: false
type: Reaction

358388
stoichiometry: 1.0
species: 767116
type: SpeciesReference

350531
stoichiometry: 1.0
species: 763956
type: SpeciesReference

353794
stoichiometry: 1.0
species: 769136
type: SpeciesReference

360009
stoichiometry: 1.0
species: 767636
type: SpeciesReference

765316
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 763757
type: Species

830112
units: 344978
value: 2.7E-14
type: LocalParameter

351272
stoichiometry: 1.0
species: 763956
type: SpeciesReference

357446
stoichiometry: 1.0
species: 766916
type: SpeciesReference

353842
stoichiometry: 1.0
species: 766076
type: SpeciesReference

358183
stoichiometry: 1.0
species: 766376
type: SpeciesReference

362513
stoichiometry: 1.0
species: 768576
type: SpeciesReference

830271
units: 344978
value: 2.25E-16
type: LocalParameter

359659
stoichiometry: 1.0
species: 767636
type: SpeciesReference

349105
stoichiometry: 1.0
species: 764096
type: SpeciesReference

352112
local parameters: 830700
local parameters: 830697
notes: k1*PP1_slash_PP1_minus_I1_star_*PP2A-k2*PP2A_slash_PP2A_minus_dephosph_minus_PP1_minus_I_star__slash_PP2A_minus_dephosph_minus_PP1_minus_I_star__cplx
type: KineticLaw

348003
stoichiometry: 1.0
species: 763797
type: SpeciesReference

830496
units: 344978
value: 5.4E-16
type: LocalParameter

356809
local parameters: 831136
notes: k3*PP1_minus_active_PSD_slash_PP1_sbo_15_sbc__slash_PP1_sbo_15_sbc__cplx
type: KineticLaw

770636
kinetic law: 346834
product: 346822
product: 346810
reactant: 346798
notes: Let us assume that the equil in this case is very far over to the right. This is probably safe.
fast: false
reversible: true
type: Reaction

830166
units: 344978
value: 1.0E-17
type: LocalParameter

773176
kinetic law: 352890
product: 352878
reactant: 352866
reactant: 352854
notes: Rate is 1/6 of the CaM stim form. We\'ll just reduce all lf k1, k2, k3 so that the Vmax goes down 1/6.
fast: false
reversible: true
type: Reaction

354238
local parameters: 830901
local parameters: 830898
notes: k1*AMPAR_memb_slash_A_B831_star_845_star_*actCaMKII_minus_PSD-k2*actCaMKII_minus_PSD_slash_CaMKII_sbo_9_sbc__slash_CaMKII_sbo_9_sbc__cplx
type: KineticLaw

770576
kinetic law: 346714
product: 346702
reactant: 346690
reactant: 346678
notes: Same values as for the main compartment Can the main compartment pool of Ca/CaM be used?
fast: false
reversible: true
type: Reaction

350603
local parameters: 830559
notes: k3*PKA_minus_active_slash_PKA_sbo_5_sbc__slash_PKA_sbo_5_sbc__cplx
type: KineticLaw

355730
stoichiometry: 1.0
species: 766376
type: SpeciesReference

352694
local parameters: 830757
local parameters: 830754
notes: k1*cAMP*AC_slash_cAMP_minus_PDE-k2*AC_slash_cAMP_minus_PDE_slash_PDE_slash_PDE_cplx
type: KineticLaw

773796
kinetic law: 354382
product: 354370
product: 354358
reactant: 354346
fast: false
reversible: false
type: Reaction

773956
kinetic law: 354770
product: 354758
product: 354746
reactant: 354733
fast: false
reversible: false
type: Reaction

346907
stoichiometry: 1.0
species: 763936
type: SpeciesReference

353397
stoichiometry: 1.0
species: 768776
type: SpeciesReference

361774
stoichiometry: 1.0
species: 768796
type: SpeciesReference

348682
stoichiometry: 1.0
species: 763956
type: SpeciesReference

766436
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 763776
type: Species

361291
stoichiometry: 1.0
species: 768596
type: SpeciesReference

348114
stoichiometry: 1.0
species: 763896
type: SpeciesReference

829974
units: 345062
value: 3.2400162E-16
type: LocalParameter

352998
stoichiometry: 1.0
species: 765696
type: SpeciesReference

349044
local parameters: 830415
notes: k3*PKA_minus_active_slash_PKA_sbo_21_sbc__slash_PKA_sbo_21_sbc__cplx
type: KineticLaw

831262
units: 344978
value: 3.5E-18
type: LocalParameter

354527
local parameters: 830928
local parameters: 830925
notes: k1*AMPAR_memb_slash_A831_star_845_star__B845_star_*actCaMKII_minus_PSD-k2*actCaMKII_minus_PSD_slash_CaMKII_sbo_12_sbc__slash_CaMKII_sbo_12_sbc__cplx
type: KineticLaw

770836
kinetic law: 347267
product: 347255
reactant: 347243
fast: false
reversible: true
type: Reaction

769916
kinetic law: 345175
product: 345162
reactant: 345149
reactant: 345136
notes: K inhib = 1nM from Cohen Ann Rev Bioch 1989, 4 nM from Foukes et al Assume 2 nM. kf /kb = 8.333e-4
fast: false
reversible: true
type: Reaction

347267
local parameters: 830229
local parameters: 830226
notes: kf*AMPAR_slash_A831_star_845_star__B845_star_-kb*AMPAR_slash_AMPAR_deg
type: KineticLaw

767976
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 763757
type: Species

350675
stoichiometry: 1.0
species: 768716
type: SpeciesReference

769956
kinetic law: 345279
product: 345266
reactant: 345253
reactant: 345240
notes: Affinity is up 1000X. Time to release is about 20 sec, so the kb is OK at 0.1 This makes Kf around 1.6666e-3
fast: false
reversible: true
type: Reaction

349370
stoichiometry: 1.0
species: 764156
type: SpeciesReference

766376
constant: false
boundary condition: false
has only substance units: false
initial concentration: 8.0
initial amount: NaN
in compartment: 763776
type: Species

830115
units: 344978
value: 2.7E-14
type: LocalParameter

830697
units: 345062
value: 5.81256E-17
type: LocalParameter

352902
stoichiometry: 1.0
species: 765656
type: SpeciesReference

776715
kinetic law: 362149
product: 362137
product: 362125
reactant: 362113
fast: false
reversible: false
type: Reaction

361351
stoichiometry: 1.0
species: 768516
type: SpeciesReference

348718
stoichiometry: 1.0
species: 764037
type: SpeciesReference

773916
kinetic law: 354672
product: 354660
product: 354648
reactant: 354636
fast: false
reversible: false
type: Reaction

355694
local parameters: 831034
local parameters: 831031
notes: k1*AMPAR_memb_slash_A831_star_845_star__B845_star_*PP1_minus_active_PSD-k2*PP1_minus_active_PSD_slash_PP1_sbo_4_sbc__slash_PP1_sbo_4_sbc__cplx
type: KineticLaw

831322
units: 344978
value: 2.106E-16
type: LocalParameter

362586
local parameters: 831673
local parameters: 831670
notes: k1*CaM_slash_neurogranin_star__PSD*CaM_Ca_n_minus_CaNAB-k2*CaM_Ca_n_minus_CaNAB_slash_dephosph_neurogranin_PSD_slash_dephosph_neurogranin_PSD_cplx
type: KineticLaw

773216
kinetic law: 352986
product: 352974
reactant: 352962
reactant: 352950
notes: Max activity ~10umol/min/mg in presence of lots of CaM. Affinity is low, 40 uM. k3 = 10, k2 = 40, k1 = (50/40) / 6e5.
fast: false
reversible: true
type: Reaction

831298
units: 344978
value: 5.22E-17
type: LocalParameter

345955
stoichiometry: 1.0
species: 763916
type: SpeciesReference

354831
stoichiometry: 1.0
species: 766276
type: SpeciesReference

775735
kinetic law: 359781
product: 359768
reactant: 359755
reactant: 359743
fast: false
reversible: true
type: Reaction

830736
units: 344978
value: 1.224E-17
type: LocalParameter

774855
kinetic law: 357626
product: 357614
reactant: 357602
reactant: 357590
fast: false
reversible: true
type: Reaction

771576
kinetic law: 348996
product: 348984
reactant: 348972
reactant: 348960
fast: false
reversible: true
type: Reaction

360203
stoichiometry: 1.0
species: 767636
type: SpeciesReference

830019
units: 344978
value: 0.0
type: LocalParameter

352088
stoichiometry: 1.0
species: 765076
type: SpeciesReference

769056
constant: false
boundary condition: true
has only substance units: false
initial concentration: 2.0
initial amount: NaN
in compartment: 763757
type: Species

831646
units: 344978
value: 7.2E-16
type: LocalParameter

360276
stoichiometry: 1.0
species: 767916
type: SpeciesReference

354575
local parameters: 830929
notes: k3*actCaMKII_minus_PSD_slash_CaMKII_sbo_12_sbc__slash_CaMKII_sbo_12_sbc__cplx
type: KineticLaw

831295
units: 344978
value: 2.106E-16
type: LocalParameter

831115
units: 344978
value: 6.8E-18
type: LocalParameter

830778
units: 344978
value: 1.5003E-16
type: LocalParameter

831532
units: 344978
value: 1.8E-16
type: LocalParameter

770416
kinetic law: 346339
product: 346327
reactant: 346315
notes: The rates for this are poorly constrained. In adipocytes (probably a different PDE) the dephosphorylation is complete within 15 min, but there are no intermediate time points so it could be much faster. Identity of phosphatase etc is still unknown.
fast: false
reversible: true
type: Reaction

350048
stoichiometry: 1.0
species: 764276
type: SpeciesReference

830118
units: 345062
value: 4.99998E-16
type: LocalParameter

348984
stoichiometry: 1.0
species: 764076
type: SpeciesReference

766776
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 763776
type: Species

358303
local parameters: 831277
local parameters: 831274
notes: k1*AMPAR_memb_slash_A831_star__B831_star_*PP1_minus_active_PSD-k2*PP1_minus_active_PSD_slash_PP1_sbo_31_sbc__slash_PP1_sbo_31_sbc__cplx
type: KineticLaw

358496
local parameters: 831295
local parameters: 831292
notes: k1*CaM_slash_neurogranin*PKC_minus_active-k2*PKC_minus_active_slash_PKC_minus_phosph_minus_neurogranin_slash_PKC_minus_phosph_minus_neurogranin_cplx
type: KineticLaw

831220
units: 345062
value: 8.7498E-18
type: LocalParameter

350967
stoichiometry: 1.0
species: 768796
type: SpeciesReference

358837
stoichiometry: 1.0
species: 767136
type: SpeciesReference

831685
units: 344978
value: 6.0E-17
type: LocalParameter

358532
stoichiometry: 1.0
species: 767136
type: SpeciesReference

345424
local parameters: 829983
local parameters: 829980
notes: kf*CaM_slash_neurogranin*CaM_slash_CaM-kb*CaM_slash_neurogranin_minus_CaM
type: KineticLaw

353301
stoichiometry: 1.0
species: 765776
type: SpeciesReference

352220
stoichiometry: 1.0
species: 765136
type: SpeciesReference

346436
stoichiometry: 1.0
species: 765796
type: SpeciesReference

354418
stoichiometry: 1.0
species: 766196
type: SpeciesReference

346774
stoichiometry: 1.0
species: 763796
type: SpeciesReference

356521
local parameters: 831109
notes: k3*PP1_minus_active_PSD_slash_PP1_sbo_12_sbc__slash_PP1_sbo_12_sbc__cplx
type: KineticLaw

351906
stoichiometry: 1.0
species: 764756
type: SpeciesReference

359490
local parameters: 831385
local parameters: 831382
notes: k1*AMPAR_slash_A845_star__B*CaM_Ca_n_minus_CaNAB-k2*CaM_Ca_n_minus_CaNAB_slash_PP2B_sbo_17_sbc__slash_PP2B_sbo_17_sbc__cplx
type: KineticLaw

829971
units: 344978
value: 6.48E-15
type: LocalParameter

831070
units: 344978
value: 1.4E-17
type: LocalParameter

359379
stoichiometry: 1.0
species: 767736
type: SpeciesReference

772876
kinetic law: 352160
product: 352148
product: 352136
reactant: 352124
fast: false
reversible: false
type: Reaction

772216
kinetic law: 350555
product: 350543
reactant: 350531
reactant: 350519
fast: false
reversible: true
type: Reaction

359006
local parameters: 831340
local parameters: 831337
notes: k1*CaM_slash_neurogranin_star_*CaM_Ca_n_minus_CaNAB-k2*CaM_Ca_n_minus_CaNAB_slash_dephosph_neurogranin_slash_dephosph_neurogranin_cplx
type: KineticLaw

355084
stoichiometry: 1.0
species: 766376
type: SpeciesReference

349807
stoichiometry: 1.0
species: 763956
type: SpeciesReference

361242
stoichiometry: 1.0
species: 768116
type: SpeciesReference

831181
units: 344978
value: 3.5E-18
type: LocalParameter

830880
units: 345062
value: 2.77776E-19
type: LocalParameter

345919
stoichiometry: 1.0
species: 765296
type: SpeciesReference

773396
kinetic law: 353421
product: 353409
product: 353397
reactant: 353385
fast: false
reversible: false
type: Reaction

831535
units: 345062
value: 2.011824E-17
type: LocalParameter

831328
units: 345062
value: 6.11982E-19
type: LocalParameter

830169
units: 345062
value: 0.0
type: LocalParameter

356677
stoichiometry: 1.0
species: 766756
type: SpeciesReference

347967
stoichiometry: 1.0
species: 763797
type: SpeciesReference

830802
units: 344978
value: 2.0E-17
type: LocalParameter

359551
stoichiometry: 1.0
species: 767356
type: SpeciesReference

830493
units: 344978
value: 2.16E-15
type: LocalParameter

360892
local parameters: 831514
notes: k3*CaM_Ca_n_minus_CaNAB_slash_PP2B_sbo_31_sbc__slash_PP2B_sbo_31_sbc__cplx
type: KineticLaw

767616
constant: false
boundary condition: false
has only substance units: false
initial concentration: 120.0
initial amount: NaN
in compartment: 763776
type: Species

359611
stoichiometry: 1.0
species: 767316
type: SpeciesReference

764856
constant: false
boundary condition: false
has only substance units: false
initial concentration: 10.0
initial amount: NaN
in compartment: 763757
type: Species

830694
units: 344978
value: 1.8E-16
type: LocalParameter

361918
stoichiometry: 1.0
species: 768256
type: SpeciesReference

766836
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 763776
type: Species

352841
local parameters: 830769
notes: k3*AC_slash_cAMP_minus_PDE_star__slash_PDE_star__slash_PDE_star__cplx
type: KineticLaw

830340
units: 344978
value: 3.24E-15
type: LocalParameter

349153
stoichiometry: 1.0
species: 767556
type: SpeciesReference

349093
local parameters: 830421
local parameters: 830418
notes: k1*AMPAR_slash_A_B831_star_*PKA_minus_active-k2*PKA_minus_active_slash_PKA_sbo_22_sbc__slash_PKA_sbo_22_sbc__cplx
type: KineticLaw

357362
stoichiometry: 1.0
species: 768696
type: SpeciesReference

355546
local parameters: 831019
notes: k3*PP1_minus_active_PSD_slash_PP1_sbo_2_sbc__slash_PP1_sbo_2_sbc__cplx
type: KineticLaw

831649
units: 344978
value: 1.8E-16
type: LocalParameter

345279
local parameters: 829965
local parameters: 829962
notes: kf*CaMKII_slash_CaMKII_minus_thr286*CaM_minus_Ca4-kb*CaMKII_slash_CaMKII_minus_thr286_star__minus_CaM
type: KineticLaw

830016
units: 344978
value: 5.0E-20
type: LocalParameter

355072
stoichiometry: 1.0
species: 765816
type: SpeciesReference

347603
stoichiometry: 1.0
species: 765956
type: SpeciesReference

772256
kinetic law: 350651
product: 350639
reactant: 350627
reactant: 350615
fast: false
reversible: true
type: Reaction

362210
stoichiometry: 1.0
species: 768316
type: SpeciesReference

354082
stoichiometry: 1.0
species: 769136
type: SpeciesReference

355146
stoichiometry: 1.0
species: 766376
type: SpeciesReference

347567
stoichiometry: 1.0
species: 767136
type: SpeciesReference

361846
stoichiometry: 1.0
species: 767636
type: SpeciesReference

831112
units: 345062
value: 8.7498E-18
type: LocalParameter

830775
units: 344978
value: 6.003E-16
type: LocalParameter

352658
stoichiometry: 1.0
species: 763916
type: SpeciesReference

360735
stoichiometry: 1.0
species: 768016
type: SpeciesReference

775675
kinetic law: 359635
product: 359623
product: 359611
reactant: 359599
fast: false
reversible: false
type: Reaction

353806
local parameters: 830859
notes: k3*actCaMKII_minus_PSD_slash_CaMKII_sbo_4_sbc__slash_CaMKII_sbo_4_sbc__cplx
type: KineticLaw

831688
units: 345062
value: 7.8126E-20
type: LocalParameter

350419
stoichiometry: 1.0
species: 768716
type: SpeciesReference

345991
stoichiometry: 1.0
species: 765316
type: SpeciesReference

348875
stoichiometry: 1.0
species: 763956
type: SpeciesReference

770996
kinetic law: 347615
product: 347603
reactant: 347591
fast: false
reversible: true
type: Reaction

354046
local parameters: 830883
local parameters: 830880
notes: k1*AMPAR_memb_slash_A_B*actCaMKII_minus_PSD-k2*actCaMKII_minus_PSD_slash_CaMKII_sbo_7_sbc__slash_CaMKII_sbo_7_sbc__cplx
type: KineticLaw

351955
stoichiometry: 1.0
species: 769056
type: SpeciesReference

349466
stoichiometry: 1.0
species: 764176
type: SpeciesReference

362368
stoichiometry: 1.0
species: 767636
type: SpeciesReference

347459
stoichiometry: 1.0
species: 767396
type: SpeciesReference

830382
units: 345062
value: 3.5998992E-16
type: LocalParameter

775055
kinetic law: 358110
product: 358098
reactant: 358086
reactant: 358074
fast: false
reversible: true
type: Reaction

772616
kinetic law: 351529
product: 351517
reactant: 351505
reactant: 351493
fast: false
reversible: true
type: Reaction

360312
local parameters: 831460
notes: k3*CaM_Ca_n_minus_CaNAB_slash_PP2B_sbo_25_sbc__slash_PP2B_sbo_25_sbc__cplx
type: KineticLaw

351003
stoichiometry: 1.0
species: 768556
type: SpeciesReference

775515
kinetic law: 359247
product: 359235
product: 359223
reactant: 359211
fast: false
reversible: false
type: Reaction

354684
stoichiometry: 1.0
species: 768616
type: SpeciesReference

776355
kinetic law: 361279
product: 361267
product: 361254
reactant: 361242
fast: false
reversible: false
type: Reaction

773476
kinetic law: 353614
product: 353602
product: 353590
reactant: 353578
fast: false
reversible: false
type: Reaction

357590
stoichiometry: 1.0
species: 768816
type: SpeciesReference

773356
kinetic law: 353325
product: 353313
product: 353301
reactant: 353289
fast: false
reversible: false
type: Reaction

831577
units: 344978
value: 1.8E-16
type: LocalParameter

830226
units: 344978
value: 3.24E-21
type: LocalParameter

830586
units: 344978
value: 5.4E-16
type: LocalParameter

830805
units: 344978
value: 5.0E-18
type: LocalParameter

771776
kinetic law: 349478
product: 349466
reactant: 349454
reactant: 349442
fast: false
reversible: true
type: Reaction

831700
units: 344978
value: 8.0E-17
type: LocalParameter

359283
stoichiometry: 1.0
species: 767716
type: SpeciesReference

350060
local parameters: 830511
local parameters: 830508
notes: k1*AMPAR_memb_slash_A_B845_star_*PKA_minus_active-k2*PKA_minus_active_slash_PKA_slash_PKA_cplx
type: KineticLaw

357821
local parameters: 831232
local parameters: 831229
notes: k1*AMPAR_memb_slash_A831_star_845_star__B831_star_*PP1_minus_active_PSD-k2*PP1_minus_active_PSD_slash_PP1_sbo_26_sbc__slash_PP1_sbo_26_sbc__cplx
type: KineticLaw

355461
stoichiometry: 1.0
species: 768596
type: SpeciesReference

830886
units: 344978
value: 5.0E-18
type: LocalParameter

350158
local parameters: 830520
local parameters: 830517
notes: k1*AMPAR_memb_slash_A845_star__B*PKA_minus_active-k2*PKA_minus_active_slash_PKA_sbo_1_sbc__slash_PKA_sbo_1_sbc__cplx
type: KineticLaw

349612
stoichiometry: 1.0
species: 763956
type: SpeciesReference

346883
local parameters: 830175
local parameters: 830172
notes: kf*PP1_PSD_slash_I1_star_*PP1_minus_active_PSD-kb*PP1_PSD_slash_PP1_minus_I1_star_
type: KineticLaw

348790
stoichiometry: 1.0
species: 764056
type: SpeciesReference

345315
stoichiometry: 1.0
species: 764976
type: SpeciesReference

767476
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 763757
type: Species

830772
units: 345062
value: 1.8900054E-17
type: LocalParameter

767176
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 763757
type: Species

831538
units: 344978
value: 7.2E-16
type: LocalParameter

360384
stoichiometry: 1.0
species: 767596
type: SpeciesReference

349915
local parameters: 830496
notes: k3*PKA_minus_active_slash_PKA_sbo_30_sbc__slash_PKA_sbo_30_sbc__cplx
type: KineticLaw

830844
units: 345062
value: 2.77776E-19
type: LocalParameter

764576
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 763757
type: Species

356893
stoichiometry: 1.0
species: 766376
type: SpeciesReference

358641
stoichiometry: 1.0
species: 767136
type: SpeciesReference

359223
stoichiometry: 1.0
species: 765056
type: SpeciesReference

774436
kinetic law: 356271
product: 356259
reactant: 356247
reactant: 356235
fast: false
reversible: true
type: Reaction

830229
units: 344978
value: 0.0
type: LocalParameter

764156
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 763757
type: Species

360843
local parameters: 831511
local parameters: 831508
notes: k1*AMPAR_slash_A845_star__B831_star_845_star_*CaM_Ca_n_minus_CaNAB-k2*CaM_Ca_n_minus_CaNAB_slash_PP2B_sbo_31_sbc__slash_PP2B_sbo_31_sbc__cplx
type: KineticLaw

345388
stoichiometry: 1.0
species: 764856
type: SpeciesReference

764116
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 763757
type: Species

831643
units: 345062
value: 2.011824E-17
type: LocalParameter

775595
kinetic law: 359441
product: 359428
product: 359416
reactant: 359404
fast: false
reversible: false
type: Reaction

346967
local parameters: 830187
local parameters: 830184
notes: kf*AMPAR_slash_GluR23_M-kb*AMPAR_slash_GluR23_I
type: KineticLaw

352768
stoichiometry: 1.0
species: 765596
type: SpeciesReference

348271
local parameters: 830343
notes: k3*PKA_minus_active_slash_phosph_minus_PDE_slash_phosph_minus_PDE_cplx
type: KineticLaw

353457
stoichiometry: 1.0
species: 765996
type: SpeciesReference

350380
stoichiometry: 1.0
species: 768656
type: SpeciesReference

358568
stoichiometry: 1.0
species: 767136
type: SpeciesReference

774435
kinetic law: 356223
product: 356211
product: 356199
reactant: 356187
fast: false
reversible: false
type: Reaction

771836
kinetic law: 349624
product: 349612
product: 349599
reactant: 349587
fast: false
reversible: false
type: Reaction

831442
units: 344978
value: 1.8E-16
type: LocalParameter

830847
units: 344978
value: 2.0E-17
type: LocalParameter

345099
exponent: -1.0
scale: 0
multipler: 1.0
kind: SECOND
type: SBMLUnit

830490
units: 345062
value: 3.5998992E-16
type: LocalParameter

356953
local parameters: 831151
local parameters: 831148
notes: k1*AMPAR_memb_slash_A835_star_845_star__B835_star_845_star_*PP1_minus_active_PSD-k2*PP1_minus_active_PSD_slash_PP1_sbo_17_sbc__slash_PP1_sbo_17_sbc__cplx
type: KineticLaw

830277
units: 344978
value: 1.0E-15
type: LocalParameter

768856
notes: ATP is present in all cells between 2 and 10 mM. See Lehninger
constant: true
boundary condition: true
has only substance units: false
initial concentration: 2000.0
initial amount: NaN
in compartment: 763757
type: Species

830385
units: 344978
value: 2.16E-15
type: LocalParameter

346375
stoichiometry: 1.0
species: 765676
type: SpeciesReference

361955
local parameters: 831613
notes: k3*CaM_Ca_n_minus_CaNAB_slash_PP2B_sbo_9_sbc__slash_PP2B_sbo_9_sbc__cplx
type: KineticLaw

362039
stoichiometry: 1.0
species: 767636
type: SpeciesReference

358605
stoichiometry: 1.0
species: 767176
type: SpeciesReference

830883
units: 344978
value: 2.0E-17
type: LocalParameter

357253
stoichiometry: 1.0
species: 766876
type: SpeciesReference

767596
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 763757
type: Species

348911
stoichiometry: 1.0
species: 764057
type: SpeciesReference

352950
stoichiometry: 1.0
species: 763916
type: SpeciesReference

361303
stoichiometry: 1.0
species: 767636
type: SpeciesReference

768256
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 763757
type: Species

830163
units: 344978
value: 5.4E-15
type: LocalParameter

831268
units: 344978
value: 1.4E-17
type: LocalParameter

356283
stoichiometry: 1.0
species: 766676
type: SpeciesReference

830808
units: 345062
value: 1.99998E-19
type: LocalParameter

830962
units: 344978
value: 8.0E-18
type: LocalParameter

356569
local parameters: 831115
local parameters: 831112
notes: k1*AMPAR_memb_slash_A845_star__B831_star_845_star_*PP1_minus_active_PSD-k2*PP1_minus_active_PSD_slash_PP1_sbo_13_sbc__slash_PP1_sbo_13_sbc__cplx
type: KineticLaw

774176
kinetic law: 355302
product: 355290
reactant: 355278
reactant: 355266
fast: false
reversible: true
type: Reaction

352040
stoichiometry: 1.0
species: 764996
type: SpeciesReference

357338
local parameters: 831187
local parameters: 831184
notes: k1*AMPAR_memb_slash_A845_star__B831_star_845_star_*PP1_minus_active_PSD-k2*PP1_minus_active_PSD_slash_PP1_sbo_21_sbc__slash_PP1_sbo_21_sbc__cplx
type: KineticLaw

345690
local parameters: 830019
local parameters: 830016
notes: kf*CaM_slash_neurogranin_star__PSD-kb*CaM_slash_neurogranin_PSD
type: KineticLaw

348307
stoichiometry: 1.0
species: 763996
type: SpeciesReference

355314
stoichiometry: 1.0
species: 766476
type: SpeciesReference

360420
stoichiometry: 1.0
species: 767436
type: SpeciesReference

766736
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 763776
type: Species

351870
local parameters: 830676
notes: k3*CaMKII_slash_tot_autonomous_CaMKII_slash_auton_305_slash_auton_305_cplx
type: KineticLaw

362186
stoichiometry: 1.0
species: 768316
type: SpeciesReference

352317
stoichiometry: 1.0
species: 765156
type: SpeciesReference

357626
local parameters: 831214
local parameters: 831211
notes: k1*AMPAR_memb_slash_A835_star_845_star__B835_star_845_star_*PP1_minus_active_PSD-k2*PP1_minus_active_PSD_slash_PP1_sbo_24_sbc__slash_PP1_sbo_24_sbc__cplx
type: KineticLaw

767436
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 763757
type: Species

763757
constant: true
size: 9.0E-17
spatial dimensions: 3.0
type: Compartment

352269
stoichiometry: 1.0
species: 766336
type: SpeciesReference

359997
stoichiometry: 1.0
species: 767316
type: SpeciesReference

356344
stoichiometry: 1.0
species: 766376
type: SpeciesReference

359768
stoichiometry: 1.0
species: 767816
type: SpeciesReference

347339
stoichiometry: 1.0
species: 768816
type: SpeciesReference

362838
stoichiometry: 1.0
species: 765796
type: SpeciesReference

362259
stoichiometry: 1.0
species: 768816
type: SpeciesReference

358279
stoichiometry: 1.0
species: 766376
type: SpeciesReference

772976
kinetic law: 352402
product: 352390
reactant: 352377
reactant: 352365
notes: The rates here are so slow I do not know if we should even bother with this enz reacn. These numbers are from Liu and Storm. Other refs suggest that the Km stays the same but the Vmax goes to 10% of the CaM stim levels. Prev: k1=2.2e-9, k2 = 0.0052, k3 = 0.0013 New : k1=5.7e-8, k2=.136, k3=.034
fast: false
reversible: true
type: Reaction

345654
local parameters: 830013
local parameters: 830010
notes: kf*CaM_slash_neurogranin_PSD*CaM_slash_CaM_minus_PSD-kb*CaM_slash_neurogranin_minus_CaM_PSD
type: KineticLaw

361013
stoichiometry: 1.0
species: 767636
type: SpeciesReference

353034
local parameters: 830787
notes: k3*AC_slash_CaM_dot_PDE1_slash_CaM_dot_PDE1_slash_CaM_dot_PDE1_cplx
type: KineticLaw

349575
local parameters: 830466
local parameters: 830463
notes: k1*AMPAR_slash_A831_star__B831_star_845_star_*PKA_minus_active-k2*PKA_minus_active_slash_PKA_sbo_27_sbc__slash_PKA_sbo_27_sbc__cplx
type: KineticLaw

351163
stoichiometry: 1.0
species: 768676
type: SpeciesReference

353734
stoichiometry: 1.0
species: 769136
type: SpeciesReference

351846
stoichiometry: 1.0
species: 764656
type: SpeciesReference

777035
kinetic law: 362922
product: 362910
product: 362898
reactant: 362886
fast: false
reversible: false
type: Reaction

830889
units: 345062
value: 2.77776E-19
type: LocalParameter

830274
units: 344978
value: 1.0E-15
type: LocalParameter

830388
units: 344978
value: 5.4E-16
type: LocalParameter

354636
stoichiometry: 1.0
species: 766236
type: SpeciesReference

765676
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 763757
type: Species

773976
kinetic law: 354819
product: 354807
reactant: 354794
reactant: 354782
fast: false
reversible: true
type: Reaction

355350
local parameters: 831001
notes: k3*PP1_minus_active_PSD_slash_PP1_slash_PP1_cplx
type: KineticLaw

353998
local parameters: 830877
notes: k3*actCaMKII_minus_PSD_slash_CaMKII_sbo_6_sbc__slash_CaMKII_sbo_6_sbc__cplx
type: KineticLaw

769116
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 763776
type: Species

774636
kinetic law: 357049
product: 357037
reactant: 357025
reactant: 357013
fast: false
reversible: true
type: Reaction

348343
stoichiometry: 1.0
species: 765016
type: SpeciesReference

830517
units: 345062
value: 3.999888E-17
type: LocalParameter

356617
local parameters: 831118
notes: k3*PP1_minus_active_PSD_slash_PP1_sbo_13_sbc__slash_PP1_sbo_13_sbc__cplx
type: KineticLaw

774136
kinetic law: 355206
product: 355194
reactant: 355182
reactant: 355170
fast: false
reversible: true
type: Reaction

349999
stoichiometry: 1.0
species: 763956
type: SpeciesReference

766196
constant: false
boundary condition: false
has only substance units: false
initial concentration: 1.02566666666667E-215
initial amount: NaN
in compartment: 763776
type: Species

361665
local parameters: 831586
notes: k3*CaM_Ca_n_minus_CaNAB_slash_PP2B_sbo_6_sbc__slash_PP2B_sbo_6_sbc__cplx
type: KineticLaw

347375
stoichiometry: 1.0
species: 768436
type: SpeciesReference

831640
units: 344978
value: 1.8E-16
type: LocalParameter

353626
stoichiometry: 1.0
species: 768516
type: SpeciesReference

766156
constant: false
boundary condition: false
has only substance units: false
initial concentration: 2.04433333333333E-215
initial amount: NaN
in compartment: 763776
type: Species

350495
stoichiometry: 1.0
species: 763956
type: SpeciesReference

346003
stoichiometry: 1.0
species: 763916
type: SpeciesReference

831265
units: 345062
value: 8.7498E-18
type: LocalParameter

774676
kinetic law: 357193
product: 357181
product: 357169
reactant: 357157
fast: false
reversible: false
type: Reaction

764396
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 763757
type: Species

829977
units: 344978
value: 9.0E-16
type: LocalParameter

359331
stoichiometry: 1.0
species: 767636
type: SpeciesReference

770276
kinetic law: 346027
product: 346015
reactant: 346003
reactant: 345991
fast: false
reversible: true
type: Reaction

830160
units: 344978
value: 5.4E-15
type: LocalParameter

358726
stoichiometry: 1.0
species: 765496
type: SpeciesReference

772436
kinetic law: 351090
product: 351077
product: 351065
reactant: 351052
fast: false
reversible: false
type: Reaction

355947
stoichiometry: 1.0
species: 768616
type: SpeciesReference

830223
units: 344978
value: 0.0
type: LocalParameter

830589
units: 345062
value: 3.999888E-17
type: LocalParameter

353178
local parameters: 830802
local parameters: 830799
notes: k1*CaMKII_minus_CaM_minus_PSD*tot_minus_auto_minus_PSD-k2*tot_minus_auto_minus_PSD_slash_auton_minus_286_minus_PSD_slash_auton_minus_286_minus_PSD_cplx
type: KineticLaw

353770
stoichiometry: 1.0
species: 766056
type: SpeciesReference

355608
stoichiometry: 1.0
species: 766536
type: SpeciesReference

351235
local parameters: 830619
local parameters: 830616
notes: k1*AMPAR_memb_slash_A831_star__B831_star_845_star_*PKA_minus_active-k2*PKA_minus_active_slash_PKA_sbo_12_sbc__slash_PKA_sbo_12_sbc__cplx
type: KineticLaw

350895
local parameters: 830586
notes: k3*PKA_minus_active_slash_PKA_sbo_8_sbc__slash_PKA_sbo_8_sbc__cplx
type: KineticLaw

771396
kinetic law: 348562
product: 348549
product: 348537
reactant: 348524
fast: false
reversible: false
type: Reaction

346666
local parameters: 830145
local parameters: 830142
notes: kf*CaMKII_minus_thr305_minus_PSD-kb*CaMKII_slash_CaMK_minus_thr305*NMDAR
type: KineticLaw

352365
stoichiometry: 1.0
species: 765016
type: SpeciesReference

831580
units: 345062
value: 2.011824E-17
type: LocalParameter

351689
stoichiometry: 1.0
species: 764616
type: SpeciesReference

356381
stoichiometry: 1.0
species: 766696
type: SpeciesReference

354467
stoichiometry: 1.0
species: 769136
type: SpeciesReference

763876
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 763757
type: Species

347003
stoichiometry: 1.0
species: 768436
type: SpeciesReference

358086
stoichiometry: 1.0
species: 766376
type: SpeciesReference

359441
local parameters: 831379
notes: k3*CaM_Ca_n_minus_CaNAB_slash_dephosph_minus_PP1_minus_I_star__PSD_slash_dephosph_minus_PP1_minus_I_star__PSD_cplx
type: KineticLaw

358946
stoichiometry: 1.0
species: 767136
type: SpeciesReference

830965
units: 344978
value: 2.0E-18
type: LocalParameter

764716
constant: false
boundary condition: false
has only substance units: false
initial concentration: 2.44537037037037E-8
initial amount: NaN
in compartment: 763757
type: Species

347063
local parameters: 830199
local parameters: 830196
notes: kf*AMPAR_memb_slash_A_B831_star_-kb*AMPAR_slash_A_B831_star_*Anchor
type: KineticLaw

345050
exponent: -1.0
scale: 0
multipler: 1.0
kind: SECOND
type: SBMLUnit

831436
units: 345062
value: 1.8106416E-16
type: LocalParameter

355254
local parameters: 830992
notes: k3*PP1_minus_active_PSD_slash_Deph_minus_thr286c_slash_Deph_minus_thr286c_cplx
type: KineticLaw

774296
kinetic law: 355646
product: 355633
product: 355620
reactant: 355608
fast: false
reversible: false
type: Reaction

356737
stoichiometry: 1.0
species: 766376
type: SpeciesReference

356163
stoichiometry: 1.0
species: 766656
type: SpeciesReference

360905
stoichiometry: 1.0
species: 767456
type: SpeciesReference

771016
kinetic law: 347652
product: 347640
reactant: 347627
fast: false
reversible: true
type: Reaction

358026
stoichiometry: 1.0
species: 767036
type: SpeciesReference

775635
kinetic law: 359539
product: 359527
product: 359515
reactant: 359503
fast: false
reversible: false
type: Reaction

776455
kinetic law: 361520
product: 361508
reactant: 361496
reactant: 361484
fast: false
reversible: true
type: Reaction

830379
units: 344978
value: 5.4E-16
type: LocalParameter

358873
stoichiometry: 1.0
species: 767136
type: SpeciesReference

774256
kinetic law: 355497
product: 355485
reactant: 355473
reactant: 355461
fast: false
reversible: true
type: Reaction

353142
stoichiometry: 1.0
species: 765756
type: SpeciesReference

350919
stoichiometry: 1.0
species: 763956
type: SpeciesReference

764756
constant: false
boundary condition: false
has only substance units: false
initial concentration: 1.89444444444444E-5
initial amount: NaN
in compartment: 763757
type: Species

831376
units: 344978
value: 1.224E-16
type: LocalParameter

831034
units: 344978
value: 6.8E-18
type: LocalParameter

773756
kinetic law: 354286
product: 354274
product: 354262
reactant: 354250
fast: false
reversible: false
type: Reaction

768796
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 763776
type: Species

353782
stoichiometry: 1.0
species: 768796
type: SpeciesReference

830445
units: 345062
value: 3.5998992E-16
type: LocalParameter

362874
local parameters: 831700
local parameters: 831697
notes: k1*CaMKII_minus_PSD*tot_minus_CaM_minus_CaMKII_minus_PSD-k2*tot_minus_CaM_minus_CaMKII_minus_PSD_slash_CaM_act_autoph_slash_CaM_act_autoph_cplx
type: KineticLaw

345606
local parameters: 830007
local parameters: 830004
notes: kf*CaM_minus_Ca3_minus_PSD*Ca_minus_PSD-kb*CaM_minus_Ca4_minus_PSD
type: KineticLaw

773136
kinetic law: 352792
product: 352780
reactant: 352768
reactant: 352756
notes: This form has about twice the activity of the unphosphorylated form. See Sette et al JBC 269:28 18271-18274 1994. We\'ll ignore cGMP effects for now.
fast: false
reversible: true
type: Reaction

360107
stoichiometry: 1.0
species: 767636
type: SpeciesReference

350857
stoichiometry: 1.0
species: 764436
type: SpeciesReference

830925
units: 345062
value: 2.77776E-19
type: LocalParameter

830556
units: 344978
value: 2.16E-15
type: LocalParameter

774675
kinetic law: 357145
product: 357133
reactant: 357121
reactant: 357109
fast: false
reversible: true
type: Reaction

347677
stoichiometry: 1.0
species: 767296
type: SpeciesReference

349684
stoichiometry: 1.0
species: 764196
type: SpeciesReference

345702
stoichiometry: 1.0
species: 765056
type: SpeciesReference

763836
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 763757
type: Species

348706
local parameters: 830385
local parameters: 830382
notes: k1*AMPAR_slash_A_B831_star_*PKA_minus_active-k2*PKA_minus_active_slash_PKA_sbo_18_sbc__slash_PKA_sbo_18_sbc__cplx
type: KineticLaw

764096
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 763757
type: Species

353674
stoichiometry: 1.0
species: 766036
type: SpeciesReference

770676
kinetic law: 346931
product: 346919
reactant: 346907
reactant: 346895
notes: Use K3 = 21.5 uM here from Stemmer and Klee table 3. kb/kf =21.5 * 6e5 so kf = 7.75e-7, kb = 10
fast: false
reversible: true
type: Reaction

348646
stoichiometry: 1.0
species: 763956
type: SpeciesReference

353518
local parameters: 830832
notes: k3*actCaMKII_minus_PSD_slash_CaMKII_sbo_1_sbc__slash_CaMKII_sbo_1_sbc__cplx
type: KineticLaw

774216
kinetic law: 355399
product: 355386
reactant: 355374
reactant: 355362
fast: false
reversible: true
type: Reaction

831031
units: 345062
value: 8.7498E-18
type: LocalParameter

764796
constant: false
boundary condition: false
has only substance units: false
initial concentration: 26.3333333333333
initial amount: NaN
in compartment: 763757
type: Species

354262
stoichiometry: 1.0
species: 768756
type: SpeciesReference

830514
units: 344978
value: 5.4E-16
type: LocalParameter

359054
local parameters: 831343
notes: k3*CaM_Ca_n_minus_CaNAB_slash_dephosph_neurogranin_slash_dephosph_neurogranin_cplx
type: KineticLaw

357181
stoichiometry: 1.0
species: 766376
type: SpeciesReference

830928
units: 344978
value: 2.0E-17
type: LocalParameter

767656
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 763757
type: Species

764057
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 763757
type: Species

776415
kinetic law: 361424
product: 361412
reactant: 361400
reactant: 361388
fast: false
reversible: true
type: Reaction

354118
stoichiometry: 1.0
species: 769136
type: SpeciesReference

775995
kinetic law: 360408
product: 360396
product: 360384
reactant: 360372
fast: false
reversible: false
type: Reaction

350796
local parameters: 830577
notes: k3*PKA_minus_active_slash_PKA_sbo_7_sbc__slash_PKA_sbo_7_sbc__cplx
type: KineticLaw

831487
units: 344978
value: 1.8E-16
type: LocalParameter

771316
kinetic law: 348367
product: 348355
product: 348343
reactant: 348331
fast: false
reversible: false
type: Reaction

830553
units: 345062
value: 3.999888E-17
type: LocalParameter

361520
local parameters: 831574
local parameters: 831571
notes: k1*AMPAR_memb_slash_A831_star_845_star__B845_star_*CaM_Ca_n_minus_CaNAB-k2*CaM_Ca_n_minus_CaNAB_slash_PP2B_sbo_5_sbc__slash_PP2B_sbo_5_sbc__cplx
type: KineticLaw

776755
kinetic law: 362247
product: 362234
product: 362222
reactant: 362210
fast: false
reversible: false
type: Reaction

831010
units: 344978
value: 1.7E-18
type: LocalParameter

346051
stoichiometry: 1.0
species: 765336
type: SpeciesReference

831583
units: 344978
value: 7.2E-16
type: LocalParameter

769416
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 763757
type: Species

771356
kinetic law: 348463
product: 348451
product: 348439
reactant: 348427
fast: false
reversible: false
type: Reaction

765096
constant: false
boundary condition: false
has only substance units: false
initial concentration: 1.99333333333333E-6
initial amount: NaN
in compartment: 763757
type: Species

362766
stoichiometry: 1.0
species: 768476
type: SpeciesReference

357025
stoichiometry: 1.0
species: 766376
type: SpeciesReference

775955
kinetic law: 360312
product: 360300
product: 360288
reactant: 360276
fast: false
reversible: false
type: Reaction

776135
kinetic law: 360747
product: 360735
reactant: 360723
reactant: 360710
fast: false
reversible: true
type: Reaction

830968
units: 345062
value: 4.99998E-18
type: LocalParameter

830232
units: 344978
value: 3.24E-21
type: LocalParameter

768376
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 763757
type: Species

356055
stoichiometry: 1.0
species: 766376
type: SpeciesReference

355995
stoichiometry: 1.0
species: 766616
type: SpeciesReference

346738
stoichiometry: 1.0
species: 763936
type: SpeciesReference

764056
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 763757
type: Species

359913
stoichiometry: 1.0
species: 767636
type: SpeciesReference

831439
units: 344978
value: 7.2E-16
type: LocalParameter

359841
stoichiometry: 1.0
species: 767376
type: SpeciesReference

347713
stoichiometry: 1.0
species: 763797
type: SpeciesReference

348379
stoichiometry: 1.0
species: 766296
type: SpeciesReference

360783
stoichiometry: 1.0
species: 767636
type: SpeciesReference

830667
units: 344978
value: 4.5E-17
type: LocalParameter

362477
stoichiometry: 1.0
species: 768376
type: SpeciesReference

764216
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 763757
type: Species

768036
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 763757
type: Species

358134
stoichiometry: 1.0
species: 768716
type: SpeciesReference

351701
stoichiometry: 1.0
species: 769036
type: SpeciesReference

830550
units: 344978
value: 5.4E-16
type: LocalParameter

767756
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 763757
type: Species

354154
stoichiometry: 1.0
species: 766136
type: SpeciesReference

352547
local parameters: 830739
notes: k3*CaNAB_minus_Ca4_slash_dephosph_inhib1_noCaM_PSD_slash_dephosph_inhib1_noCaM_PSD_cplx
type: KineticLaw

769016
constant: true
boundary condition: true
has only substance units: false
initial concentration: 0.00925933333333333
initial amount: NaN
in compartment: 763777
type: Species

355218
stoichiometry: 1.0
species: 766456
type: SpeciesReference

357554
stoichiometry: 1.0
species: 768516
type: SpeciesReference

355886
local parameters: 831052
local parameters: 831049
notes: k1*AMPAR_memb_slash_A831_star__B845_star_*PP1_minus_active_PSD-k2*PP1_minus_active_PSD_slash_PP1_sbo_6_sbc__slash_PP1_sbo_6_sbc__cplx
type: KineticLaw

350711
stoichiometry: 1.0
species: 768536
type: SpeciesReference

351578
local parameters: 830649
notes: k3*PKA_minus_active_slash_PKA_sbo_15_sbc__slash_PKA_sbo_15_sbc__cplx
type: KineticLaw

830511
units: 344978
value: 2.16E-15
type: LocalParameter

355570
stoichiometry: 1.0
species: 766376
type: SpeciesReference

830841
units: 344978
value: 5.0E-18
type: LocalParameter

355399
local parameters: 831007
local parameters: 831004
notes: k1*AMPAR_memb_slash_A845_star__B845_star_*PP1_minus_active_PSD-k2*PP1_minus_active_PSD_slash_PP1_sbo_1_sbc__slash_PP1_sbo_1_sbc__cplx
type: KineticLaw

344966
exponent: 1.0
scale: -6
multipler: 1.0
kind: MOLE
type: SBMLUnit

776975
kinetic law: 362778
product: 362766
reactant: 362754
reactant: 362742
fast: false
reversible: true
type: Reaction

348537
stoichiometry: 1.0
species: 767336
type: SpeciesReference

353950
local parameters: 830874
local parameters: 830871
notes: k1*AMPAR_memb_slash_A845_star__B*actCaMKII_minus_PSD-k2*actCaMKII_minus_PSD_slash_CaMKII_sbo_6_sbc__slash_CaMKII_sbo_6_sbc__cplx
type: KineticLaw

775375
kinetic law: 358898
product: 358886
reactant: 358873
reactant: 358861
notes: Rates are 60% those of PKC-phosph-neurogranin. See Huang et al ABB 305:2 570-580 1993
fast: false
reversible: true
type: Reaction

354867
local parameters: 830956
notes: k3*actCaMKII_minus_PSD_slash_CaMKII_sbo_15_sbc__slash_CaMKII_sbo_15_sbc__cplx
type: KineticLaw

356139
stoichiometry: 1.0
species: 768716
type: SpeciesReference

361738
stoichiometry: 1.0
species: 768536
type: SpeciesReference

353252
stoichiometry: 1.0
species: 769096
type: SpeciesReference

775335
kinetic law: 358800
product: 358788
reactant: 358776
reactant: 358763
notes: Rates from Huang et al ABB 305:2 570-580 1993
fast: false
reversible: true
type: Reaction

767716
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 763757
type: Species

354903
stoichiometry: 1.0
species: 766396
type: SpeciesReference

345870
stoichiometry: 1.0
species: 767636
type: SpeciesReference

359805
stoichiometry: 1.0
species: 767556
type: SpeciesReference

831703
units: 344978
value: 2.0E-17
type: LocalParameter

830929
units: 344978
value: 5.0E-18
type: LocalParameter

354310
stoichiometry: 1.0
species: 769136
type: SpeciesReference

348163
stoichiometry: 1.0
species: 763797
type: SpeciesReference

830595
units: 344978
value: 5.4E-16
type: LocalParameter

345460
local parameters: 829989
local parameters: 829986
notes: kf*CaM_slash_neurogranin_star_-kb*CaM_slash_neurogranin
type: KineticLaw

348574
stoichiometry: 1.0
species: 767316
type: SpeciesReference

770736
kinetic law: 347063
product: 347051
product: 347039
reactant: 347027
fast: false
reversible: true
type: Reaction

355108
local parameters: 830980
local parameters: 830977
notes: k1*CaMKII_star__star__star__minus_PSD*PP1_minus_active_PSD-k2*PP1_minus_active_PSD_slash_Deph_minus_thr305_slash_Deph_minus_thr305_cplx
type: KineticLaw

831586
units: 344978
value: 1.8E-16
type: LocalParameter

349951
stoichiometry: 1.0
species: 764256
type: SpeciesReference

831379
units: 344978
value: 3.06E-17
type: LocalParameter

831433
units: 344978
value: 1.8E-16
type: LocalParameter

765016
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 763757
type: Species

358982
stoichiometry: 1.0
species: 767636
type: SpeciesReference

764896
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 763776
type: Species

356845
stoichiometry: 1.0
species: 766796
type: SpeciesReference

360747
local parameters: 831502
local parameters: 831499
notes: k1*AMPAR_slash_A831_star_845_star__B845_star_*CaM_Ca_n_minus_CaNAB-k2*CaM_Ca_n_minus_CaNAB_slash_PP2B_sbo_30_sbc__slash_PP2B_sbo_30_sbc__cplx
type: KineticLaw

767816
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 763757
type: Species

772076
kinetic law: 350206
product: 350194
product: 350182
reactant: 350170
fast: false
reversible: false
type: Reaction

775195
kinetic law: 358448
product: 358436
product: 358424
reactant: 358412
fast: false
reversible: false
type: Reaction

358231
stoichiometry: 1.0
species: 768616
type: SpeciesReference

351090
local parameters: 830604
notes: k3*PKA_minus_active_slash_PKA_sbo_10_sbc__slash_PKA_sbo_10_sbc__cplx
type: KineticLaw

350808
stoichiometry: 1.0
species: 768736
type: SpeciesReference

353566
local parameters: 830838
local parameters: 830835
notes: k1*AMPAR_memb_slash_A845_star__B*actCaMKII_minus_PSD-k2*actCaMKII_minus_PSD_slash_CaMKII_sbo_2_sbc__slash_CaMKII_sbo_2_sbc__cplx
type: KineticLaw

830592
units: 344978
value: 2.16E-15
type: LocalParameter

772036
kinetic law: 350108
product: 350096
product: 350084
reactant: 350072
fast: false
reversible: false
type: Reaction

349503
stoichiometry: 1.0
species: 767436
type: SpeciesReference

362137
stoichiometry: 1.0
species: 767636
type: SpeciesReference

830442
units: 344978
value: 5.4E-16
type: LocalParameter

359163
stoichiometry: 1.0
species: 765036
type: SpeciesReference

830067
units: 344978
value: 2.925E-15
type: LocalParameter

347869
stoichiometry: 1.0
species: 763797
type: SpeciesReference

361991
stoichiometry: 1.0
species: 768276
type: SpeciesReference

766696
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 763776
type: Species

774895
kinetic law: 357724
product: 357712
reactant: 357699
reactant: 357687
fast: false
reversible: true
type: Reaction

360468
stoichiometry: 1.0
species: 767956
type: SpeciesReference

831484
units: 344978
value: 7.2E-16
type: LocalParameter

766876
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 763776
type: Species

346628
stoichiometry: 1.0
species: 768836
type: SpeciesReference

361412
stoichiometry: 1.0
species: 768156
type: SpeciesReference

769096
constant: false
boundary condition: true
has only substance units: false
initial concentration: 2.0
initial amount: NaN
in compartment: 763776
type: Species

359127
stoichiometry: 1.0
species: 764996
type: SpeciesReference

770776
kinetic law: 347159
product: 347147
product: 347135
reactant: 347123
fast: false
reversible: true
type: Reaction

831292
units: 345062
value: 9.180054E-18
type: LocalParameter

831481
units: 345062
value: 1.8106416E-16
type: LocalParameter

349903
stoichiometry: 1.0
species: 763956
type: SpeciesReference

357663
stoichiometry: 1.0
species: 766376
type: SpeciesReference

830730
units: 344978
value: 3.06E-18
type: LocalParameter

355182
stoichiometry: 1.0
species: 766376
type: SpeciesReference

345762
stoichiometry: 1.0
species: 765256
type: SpeciesReference

346339
local parameters: 830103
local parameters: 830100
notes: kf*AC_slash_cAMP_minus_PDE_star_-kb*AC_slash_cAMP_minus_PDE
type: KineticLaw

775555
kinetic law: 359343
product: 359331
product: 359319
reactant: 359307
fast: false
reversible: false
type: Reaction

773436
kinetic law: 353518
product: 353506
product: 353494
reactant: 353482
fast: false
reversible: false
type: Reaction

771916
kinetic law: 349819
product: 349807
product: 349795
reactant: 349783
fast: false
reversible: false
type: Reaction

356307
stoichiometry: 1.0
species: 766376
type: SpeciesReference

830025
units: 345062
value: 0.0
type: LocalParameter

770156
kinetic law: 345738
product: 345726
product: 345714
reactant: 345702
notes: Let us assume that the equil in this case is very far over to the right. This is probably safe.
fast: false
reversible: true
type: Reaction

768216
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 763757
type: Species

353202
stoichiometry: 1.0
species: 765736
type: SpeciesReference

345201
stoichiometry: 1.0
species: 764596
type: SpeciesReference

361061
stoichiometry: 1.0
species: 768656
type: SpeciesReference

764536
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 763757
type: Species

348427
stoichiometry: 1.0
species: 764016
type: SpeciesReference

774476
kinetic law: 356472
product: 356459
reactant: 356446
reactant: 356433
fast: false
reversible: true
type: Reaction

351468
stoichiometry: 1.0
species: 763956
type: SpeciesReference

357724
local parameters: 831223
local parameters: 831220
notes: k1*AMPAR_memb_slash_A831_star__B831_star_845_star_*PP1_minus_active_PSD-k2*PP1_minus_active_PSD_slash_PP1_sbo_25_sbc__slash_PP1_sbo_25_sbc__cplx
type: KineticLaw

346580
stoichiometry: 1.0
species: 765796
type: SpeciesReference

352196
stoichiometry: 1.0
species: 765136
type: SpeciesReference

768816
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 763776
type: Species

360240
stoichiometry: 1.0
species: 767636
type: SpeciesReference

355778
stoichiometry: 1.0
species: 766576
type: SpeciesReference

354758
stoichiometry: 1.0
species: 769136
type: SpeciesReference

771876
kinetic law: 349722
product: 349709
product: 349697
reactant: 349684
fast: false
reversible: false
type: Reaction

770196
kinetic law: 345834
product: 345822
reactant: 345810
reactant: 345798
notes: going on the experience with CaM, we put the fast (high affinity) sites first. We only know (Stemmer and Klee) that the affinity is < 70 nM. Assuming 10 nM at first, we get kf = 2.78e-8, kb = 1. Try 20 nM. kf = 7e-9, kb = 1
fast: false
reversible: true
type: Reaction

829980
units: 345062
value: 2.7000216E-17
type: LocalParameter

352439
stoichiometry: 1.0
species: 765176
type: SpeciesReference

356773
stoichiometry: 1.0
species: 766776
type: SpeciesReference

361629
stoichiometry: 1.0
species: 768196
type: SpeciesReference

772136
kinetic law: 350354
product: 350341
reactant: 350328
reactant: 350316
fast: false
reversible: true
type: Reaction

350458
local parameters: 830547
local parameters: 830544
notes: k1*AMPAR_memb_slash_A831_star__B845_star_*PKA_minus_active-k2*PKA_minus_active_slash_PKA_sbo_4_sbc__slash_PKA_sbo_4_sbc__cplx
type: KineticLaw

774475
kinetic law: 356420
product: 356407
product: 356394
reactant: 356381
fast: false
reversible: false
type: Reaction

765176
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 763757
type: Species

360155
stoichiometry: 1.0
species: 767896
type: SpeciesReference

831016
units: 344978
value: 6.8E-18
type: LocalParameter

831187
units: 344978
value: 1.4E-17
type: LocalParameter

346111
stoichiometry: 1.0
species: 765376
type: SpeciesReference

831694
units: 344978
value: 5.0E-18
type: LocalParameter

770116
kinetic law: 345654
product: 345642
reactant: 345630
reactant: 345618
notes: Surprisingly, no direct info on rates from neurogranin at this time. These rates are based on GAP-43 binding studies. As GAP-43 and neurogranin share near identity in the CaM/PKC binding regions, and also similarity in phosph and dephosph rates, I am borrowing GAP-43 kinetic info. See Alexander et al JBC 262:13 6108-6113 1987
fast: false
reversible: true
type: Reaction

766656
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 763776
type: Species

345123
exponent: 1.0
scale: -6
multipler: 1.0
kind: MOLE
type: SBMLUnit

830331
units: 344978
value: 9.0E-16
type: LocalParameter

767136
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.1
initial amount: NaN
in compartment: 763757
type: Species

361122
stoichiometry: 1.0
species: 768096
type: SpeciesReference

361206
stoichiometry: 1.0
species: 767636
type: SpeciesReference

356247
stoichiometry: 1.0
species: 766376
type: SpeciesReference

831184
units: 345062
value: 8.7498E-18
type: LocalParameter

354190
local parameters: 830895
notes: k3*actCaMKII_minus_PSD_slash_CaMKII_sbo_8_sbc__slash_CaMKII_sbo_8_sbc__cplx
type: KineticLaw

360638
stoichiometry: 1.0
species: 767996
type: SpeciesReference

764956
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 763757
type: Species

763936
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.08
initial amount: NaN
in compartment: 763757
type: Species

362027
stoichiometry: 1.0
species: 768556
type: SpeciesReference

355838
local parameters: 831046
notes: k3*PP1_minus_active_PSD_slash_PP1_sbo_5_sbc__slash_PP1_sbo_5_sbc__cplx
type: KineticLaw

345351
stoichiometry: 1.0
species: 763936
type: SpeciesReference

355036
stoichiometry: 1.0
species: 765796
type: SpeciesReference

830733
units: 345062
value: 3.420036E-19
type: LocalParameter

351052
stoichiometry: 1.0
species: 764476
type: SpeciesReference

830064
units: 345062
value: 6.750054E-15
type: LocalParameter

355437
stoichiometry: 1.0
species: 766376
type: SpeciesReference

772716
kinetic law: 351773
product: 351761
product: 351749
reactant: 351737
fast: false
reversible: false
type: Reaction

359515
stoichiometry: 1.0
species: 767296
type: SpeciesReference

768296
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 763757
type: Species

349262
stoichiometry: 1.0
species: 763956
type: SpeciesReference

831079
units: 344978
value: 1.4E-17
type: LocalParameter

360577
stoichiometry: 1.0
species: 767496
type: SpeciesReference

765416
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.259259259259259
initial amount: NaN
in compartment: 763757
type: Species

345162
stoichiometry: 1.0
species: 765036
type: SpeciesReference

831019
units: 344978
value: 1.7E-18
type: LocalParameter

361569
local parameters: 831577
notes: k3*CaM_Ca_n_minus_CaNAB_slash_PP2B_sbo_5_sbc__slash_PP2B_sbo_5_sbc__cplx
type: KineticLaw

775095
kinetic law: 358207
product: 358195
reactant: 358183
reactant: 358171
fast: false
reversible: true
type: Reaction

831106
units: 344978
value: 6.8E-18
type: LocalParameter

361882
stoichiometry: 1.0
species: 767636
type: SpeciesReference

765236
constant: false
boundary condition: false
has only substance units: false
initial concentration: 1.0
initial amount: NaN
in compartment: 763757
type: Species

766256
constant: false
boundary condition: false
has only substance units: false
initial concentration: 2.04433333333333E-215
initial amount: NaN
in compartment: 763776
type: Species

349843
stoichiometry: 1.0
species: 763956
type: SpeciesReference

346472
local parameters: 830121
local parameters: 830118
notes: kf*CaMKII_minus_PSD*CaM_minus_Ca4_minus_PSD-kb*CaMKII_minus_CaM_minus_PSD
type: KineticLaw

830922
units: 344978
value: 5.0E-18
type: LocalParameter

351309
stoichiometry: 1.0
species: 763956
type: SpeciesReference

772476
kinetic law: 351187
product: 351175
product: 351163
reactant: 351151
fast: false
reversible: false
type: Reaction

776295
kinetic law: 361134
product: 361122
reactant: 361110
reactant: 361097
fast: false
reversible: true
type: Reaction

830559
units: 344978
value: 5.4E-16
type: LocalParameter

771676
kinetic law: 349238
product: 349226
product: 349214
reactant: 349201
fast: false
reversible: false
type: Reaction

359731
local parameters: 831406
notes: k3*CaM_Ca_n_minus_CaNAB_slash_PP2B_sbo_19_sbc__slash_PP2B_sbo_19_sbc__cplx
type: KineticLaw

360095
stoichiometry: 1.0
species: 767516
type: SpeciesReference

830448
units: 344978
value: 2.16E-15
type: LocalParameter

346846
stoichiometry: 1.0
species: 766316
type: SpeciesReference

350567
stoichiometry: 1.0
species: 764376
type: SpeciesReference

356497
stoichiometry: 1.0
species: 768736
type: SpeciesReference

831217
units: 344978
value: 3.5E-18
type: LocalParameter

775895
kinetic law: 360167
product: 360155
reactant: 360143
reactant: 360131
fast: false
reversible: true
type: Reaction

766596
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 763776
type: Species

831373
units: 345062
value: 3.420036E-18
type: LocalParameter

830625
units: 345062
value: 3.999888E-17
type: LocalParameter

831037
units: 344978
value: 1.7E-18
type: LocalParameter

348463
local parameters: 830361
notes: k3*PKA_minus_active_slash_PKA_minus_phosph_minus_I1_PSD_slash_PKA_minus_phosph_minus_I1_PSD_cplx
type: KineticLaw

359090
stoichiometry: 1.0
species: 767676
type: SpeciesReference

357133
stoichiometry: 1.0
species: 766856
type: SpeciesReference

356917
stoichiometry: 1.0
species: 768816
type: SpeciesReference

830334
units: 344978
value: 2.25E-16
type: LocalParameter

765996
constant: false
boundary condition: false
has only substance units: false
initial concentration: 3.588E-215
initial amount: NaN
in compartment: 763776
type: Species

354358
stoichiometry: 1.0
species: 768636
type: SpeciesReference

359404
stoichiometry: 1.0
species: 767736
type: SpeciesReference

353890
stoichiometry: 1.0
species: 769136
type: SpeciesReference

362549
stoichiometry: 1.0
species: 764936
type: SpeciesReference

350266
stoichiometry: 1.0
species: 764316
type: SpeciesReference

830487
units: 344978
value: 5.4E-16
type: LocalParameter

830022
units: 344978
value: 9.0E-17
type: LocalParameter

361170
stoichiometry: 1.0
species: 767636
type: SpeciesReference

347171
stoichiometry: 1.0
species: 767456
type: SpeciesReference

774915
kinetic law: 357772
product: 357760
product: 357748
reactant: 357736
fast: false
reversible: false
type: Reaction

767336
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 763757
type: Species

357073
stoichiometry: 1.0
species: 768576
type: SpeciesReference

360045
stoichiometry: 1.0
species: 767636
type: SpeciesReference

362089
stoichiometry: 1.0
species: 768296
type: SpeciesReference

351992
stoichiometry: 1.0
species: 765076
type: SpeciesReference

347111
local parameters: 830205
local parameters: 830202
notes: kf*AMPAR_memb_slash_A831_star__B-kb*AMPAR_slash_A831_star__B*Anchor
type: KineticLaw

359599
stoichiometry: 1.0
species: 767776
type: SpeciesReference

351797
stoichiometry: 1.0
species: 769056
type: SpeciesReference

830121
units: 344978
value: 0.0
type: LocalParameter

346267
local parameters: 830091
local parameters: 830088
notes: kf*CaM_minus_Ca4*AC_slash_AC1-kb*AC_slash_AC1_minus_CaM
type: KineticLaw

352475
stoichiometry: 1.0
species: 765176
type: SpeciesReference

346556
stoichiometry: 1.0
species: 765736
type: SpeciesReference

830061
units: 344978
value: 9.9E-15
type: LocalParameter

347785
local parameters: 830298
notes: k3*PP1_minus_active_slash_Deph_minus_thr286_slash_Deph_minus_thr286_cplx
type: KineticLaw

348814
stoichiometry: 1.0
species: 764056
type: SpeciesReference

830664
units: 344978
value: 1.8E-16
type: LocalParameter

349214
stoichiometry: 1.0
species: 767496
type: SpeciesReference

770356
kinetic law: 346219
product: 346207
reactant: 346195
reactant: 346183
notes: This has to be set to zero for matching the expts in vitro. In vivo we need to consider the inhibition though. kf = 1e-5 kb = 1
fast: false
reversible: true
type: Reaction

348754
local parameters: 830388
notes: k3*PKA_minus_active_slash_PKA_sbo_18_sbc__slash_PKA_sbo_18_sbc__cplx
type: KineticLaw

347821
stoichiometry: 1.0
species: 763836
type: SpeciesReference

772776
kinetic law: 351918
product: 351906
reactant: 351894
reactant: 351882
fast: false
reversible: true
type: Reaction

348223
local parameters: 830340
local parameters: 830337
notes: k1*AC_slash_cAMP_minus_PDE*PKA_minus_active-k2*PKA_minus_active_slash_phosph_minus_PDE_slash_phosph_minus_PDE_cplx
type: KineticLaw

774535
kinetic law: 356665
product: 356653
reactant: 356641
reactant: 356629
fast: false
reversible: true
type: Reaction

831076
units: 345062
value: 8.7498E-18
type: LocalParameter

345810
stoichiometry: 2.0
species: 763936
type: SpeciesReference

359695
stoichiometry: 1.0
species: 767796
type: SpeciesReference

765956
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.08
initial amount: NaN
in compartment: 763776
type: Species

355646
local parameters: 831028
notes: k3*PP1_minus_active_PSD_slash_PP1_sbo_3_sbc__slash_PP1_sbo_3_sbc__cplx
type: KineticLaw

353349
stoichiometry: 1.0
species: 769136
type: SpeciesReference

347495
local parameters: 830259
local parameters: 830256
notes: kf*AMPAR_slash_A845_star__B845_star_*Anchor-kb*AMPAR_memb_slash_A845_star__B845_star_
type: KineticLaw

768596
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 763776
type: Species

360953
stoichiometry: 1.0
species: 768056
type: SpeciesReference

772936
kinetic law: 352305
product: 352293
reactant: 352281
reactant: 352269
notes: k1 changed from 3.3e-6 to 6.6e-6
fast: false
reversible: true
type: Reaction

830337
units: 345062
value: 5.399946E-16
type: LocalParameter

831691
units: 344978
value: 2.0E-17
type: LocalParameter

355290
stoichiometry: 1.0
species: 766476
type: SpeciesReference

831214
units: 344978
value: 1.4E-17
type: LocalParameter

830661
units: 345062
value: 9.91197E-19
type: LocalParameter

765576
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 763757
type: Species

831013
units: 345062
value: 8.7498E-18
type: LocalParameter

831109
units: 344978
value: 1.7E-18
type: LocalParameter

357760
stoichiometry: 1.0
species: 766376
type: SpeciesReference

362610
stoichiometry: 1.0
species: 764916
type: SpeciesReference

358763
stoichiometry: 1.0
species: 764916
type: SpeciesReference

831331
units: 344978
value: 1.26E-16
type: LocalParameter

764496
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 763757
type: Species

360674
stoichiometry: 1.0
species: 767336
type: SpeciesReference

356459
stoichiometry: 1.0
species: 766716
type: SpeciesReference

349322
stoichiometry: 1.0
species: 763956
type: SpeciesReference

765916
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.00254583333333333
initial amount: NaN
in compartment: 763776
type: Species

349722
local parameters: 830478
notes: k3*PKA_minus_active_slash_PKA_sbo_28_sbc__slash_PKA_sbo_28_sbc__cplx
type: KineticLaw

830622
units: 344978
value: 5.4E-16
type: LocalParameter

768556
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 763776
type: Species

831370
units: 344978
value: 3.06E-17
type: LocalParameter

361460
stoichiometry: 1.0
species: 767636
type: SpeciesReference