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constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 560155
type: Species

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units: 284793
value: 8.7498E-18
type: LocalParameter

285156
stoichiometry: 1.0
species: 565335
type: SpeciesReference

563795
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 560175
type: Species

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boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 560175
type: Species

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stoichiometry: 1.0
species: 563755
type: SpeciesReference

052414
units: 284709
value: 2.16E-15
type: LocalParameter

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stoichiometry: 1.0
species: 562955
type: SpeciesReference

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constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 560175
type: Species

291005
stoichiometry: 1.0
species: 561675
type: SpeciesReference

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stoichiometry: 1.0
species: 561195
type: SpeciesReference

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stoichiometry: 1.0
species: 561895
type: SpeciesReference

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stoichiometry: 1.0
species: 565175
type: SpeciesReference

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stoichiometry: 1.0
species: 565075
type: SpeciesReference

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stoichiometry: 1.0
species: 561355
type: SpeciesReference

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units: 284709
value: 7.2E-16
type: LocalParameter

298260
stoichiometry: 1.0
species: 563435
type: SpeciesReference

296201
local parameters: 052426
local parameters: 052423
notes: k1*AMPAR_slash_A845_star__B831_star_*PKA_slash_PKA_minus_active-k2*PKA_slash_PKA_minus_active_slash_PKA_sbo_30_sbc__slash_PKA_sbo_30_sbc__cplx
type: KineticLaw

560175
constant: true
size: 1.0E-17
spatial dimensions: 3.0
type: Compartment

287765
stoichiometry: 1.0
species: 560395
type: SpeciesReference

286584
local parameters: 051804
local parameters: 051802
notes: kf*AC_slash_PDE1*CaM_slash_CaM_minus_Ca4-kb*AC_slash_CaM_dot_PDE1
type: KineticLaw

298710
stoichiometry: 1.0
species: 563835
type: SpeciesReference

052377
units: 284709
value: 2.16E-15
type: LocalParameter

051932
units: 284793
value: 2.77776E-19
type: LocalParameter

561835
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 560155
type: Species

288369
stoichiometry: 1.0
species: 560695
type: SpeciesReference

563475
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 560155
type: Species

563855
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 560175
type: Species

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stoichiometry: 1.0
species: 565115
type: SpeciesReference

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constant: false
boundary condition: true
has only substance units: false
initial concentration: 2.0
initial amount: NaN
in compartment: 560175
type: Species

299762
stoichiometry: 1.0
species: 563755
type: SpeciesReference

296285
stoichiometry: 1.0
species: 563035
type: SpeciesReference

285096
local parameters: 051708
local parameters: 051706
notes: kf*CaMKII_slash_CaMKII_minus_CaM*CaMKII_slash_NMDAR-kb*CaMKII_slash_CaMKII_minus_CaM_minus_PSD
type: KineticLaw

052706
units: 284793
value: 8.7498E-18
type: LocalParameter

563175
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 560155
type: Species

295295
stoichiometry: 1.0
species: 564675
type: SpeciesReference

572794
kinetic law: 300801
product: 300789
product: 300777
reactant: 300765
fast: false
reversible: false
type: Reaction

298345
stoichiometry: 1.0
species: 563595
type: SpeciesReference

561155
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 560155
type: Species

300801
local parameters: 052730
notes: k3*PP1_PSD_slash_PP1_minus_active_PSD_slash_PP1_sbo_20_sbc__slash_PP1_sbo_20_sbc__cplx
type: KineticLaw

284961
stoichiometry: 1.0
species: 560435
type: SpeciesReference

572754
kinetic law: 300705
product: 300693
product: 300681
reactant: 300669
fast: false
reversible: false
type: Reaction

295585
stoichiometry: 1.0
species: 564735
type: SpeciesReference

289989
stoichiometry: 1.0
species: 561415
type: SpeciesReference

052785
units: 284709
value: 1.4E-17
type: LocalParameter

297251
stoichiometry: 1.0
species: 563235
type: SpeciesReference

560495
constant: false
boundary condition: false
has only substance units: false
initial concentration: 120.0
initial amount: NaN
in compartment: 560175
type: Species

300741
stoichiometry: 1.0
species: 564255
type: SpeciesReference

285216
stoichiometry: 1.0
species: 560475
type: SpeciesReference

568875
kinetic law: 290823
product: 290811
product: 290799
reactant: 290787
fast: false
reversible: false
type: Reaction

560795
constant: false
boundary condition: false
has only substance units: false
initial concentration: 4.06666666666667E-215
initial amount: NaN
in compartment: 560175
type: Species

052378
units: 284709
value: 5.4E-16
type: LocalParameter

569095
kinetic law: 291356
product: 291344
reactant: 291332
reactant: 291320
fast: false
reversible: true
type: Reaction

296177
stoichiometry: 1.0
species: 562655
type: SpeciesReference

568915
kinetic law: 290920
product: 290908
product: 290896
reactant: 290884
fast: false
reversible: false
type: Reaction

295851
stoichiometry: 1.0
species: 562655
type: SpeciesReference

296889
stoichiometry: 1.0
species: 563155
type: SpeciesReference

051748
units: 284709
value: 5.0E-20
type: LocalParameter

290375
stoichiometry: 1.0
species: 561515
type: SpeciesReference

288743
local parameters: 051934
local parameters: 051932
notes: k1*AMPAR_memb_slash_A_B*CaMKII_slash_actCaMKII_minus_PSD-k2*CaMKII_slash_actCaMKII_minus_PSD_slash_CaMKII_sbo_7_sbc__slash_CaMKII_sbo_7_sbc__cplx
type: KineticLaw

292451
stoichiometry: 1.0
species: 564855
type: SpeciesReference

563715
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 560175
type: Species

287479
local parameters: 051867
local parameters: 051865
notes: k1*CaMKII_slash_CaMKII_minus_thr286*CaMKII_slash_tot_CaM_CaMKII-k2*CaMKII_slash_tot_CaM_CaMKII_slash_CaM_act_305_slash_CaM_act_305_cplx
type: KineticLaw

298406
stoichiometry: 1.0
species: 563755
type: SpeciesReference

292872
stoichiometry: 1.0
species: 565135
type: SpeciesReference

566615
kinetic law: 285510
product: 285498
reactant: 285486
notes: This is put in to keep the basal levels of neurogranin* experimentally reasonable. From various papers, specially Ramakers et al JBC 270:23 1995 13892-13898, it looks like the basal level of phosph is between 20 and 40%. I est around 25 % The kf of 0.005 gives around this level at basal PKC activity levels of 0.1 uM active PKC.
fast: false
reversible: true
type: Reaction

287006
stoichiometry: 1.0
species: 565375
type: SpeciesReference

052150
units: 284709
value: 1.8E-16
type: LocalParameter

299872
stoichiometry: 1.0
species: 564075
type: SpeciesReference

052415
units: 284709
value: 5.4E-16
type: LocalParameter

051930
units: 284709
value: 5.0E-18
type: LocalParameter

298284
local parameters: 052559
notes: k3*AC_slash_PDE1_slash_PDE1_slash_PDE1_cplx
type: KineticLaw

290436
local parameters: 052044
notes: k3*PP1_slash_PP1_minus_active_slash_Deph_minus_thr305_slash_Deph_minus_thr305_cplx
type: KineticLaw

572854
kinetic law: 300945
product: 300933
reactant: 300921
reactant: 300909
fast: false
reversible: true
type: Reaction

301563
stoichiometry: 1.0
species: 563755
type: SpeciesReference

290932
stoichiometry: 1.0
species: 561295
type: SpeciesReference

293772
stoichiometry: 1.0
species: 562315
type: SpeciesReference

561235
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 560175
type: Species

563055
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 560155
type: Species

292984
stoichiometry: 1.0
species: 561675
type: SpeciesReference

563895
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 560175
type: Species

569055
kinetic law: 291260
product: 291248
reactant: 291236
reactant: 291223
fast: false
reversible: true
type: Reaction

563915
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 560175
type: Species

285683
stoichiometry: 1.0
species: 561075
type: SpeciesReference

293627
stoichiometry: 1.0
species: 561675
type: SpeciesReference

285902
stoichiometry: 1.0
species: 561455
type: SpeciesReference

571334
kinetic law: 297263
product: 297251
reactant: 297239
reactant: 297227
fast: false
reversible: true
type: Reaction

562235
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 560155
type: Species

296562
stoichiometry: 1.0
species: 562655
type: SpeciesReference

052742
units: 284709
value: 1.4E-17
type: LocalParameter

564895
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 560155
type: Species

298492
stoichiometry: 1.0
species: 560515
type: SpeciesReference

566975
kinetic law: 286366
product: 286353
product: 286341
reactant: 286328
fast: false
reversible: true
type: Reaction

299689
local parameters: 052655
local parameters: 052652
notes: k1*AMPAR_memb_slash_A831_star__B845_star_*PP1_PSD_slash_PP1_minus_active_PSD-k2*PP1_PSD_slash_PP1_minus_active_PSD_slash_PP1_sbo_9_sbc__slash_PP1_sbo_9_sbc__cplx
type: KineticLaw

286012
stoichiometry: 1.0
species: 561595
type: SpeciesReference

291115
local parameters: 052089
notes: k3*PP2B_slash_CaM_Ca_n_minus_CaNAB_slash_dephosph_minus_PP1_minus_I_star__slash_dephosph_minus_PP1_minus_I_star__cplx
type: KineticLaw

564595
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 560155
type: Species

298007
stoichiometry: 1.0
species: 563635
type: SpeciesReference

300681
stoichiometry: 1.0
species: 565015
type: SpeciesReference

287874
local parameters: 051888
local parameters: 051886
notes: k1*CaMKII_slash_CaMKII_minus_thr286_minus_PSD*CaMKII_slash_tot_minus_auto_minus_PSD-k2*CaMKII_slash_tot_minus_auto_minus_PSD_slash_auton_minus_305_minus_PSD_slash_auton_minus_305_minus_PSD_cplx
type: KineticLaw

565075
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 560175
type: Species

298867
local parameters: 052598
notes: k3*PP1_PSD_slash_PP1_minus_active_PSD_slash_PP1_slash_PP1_cplx
type: KineticLaw

299023
stoichiometry: 1.0
species: 563895
type: SpeciesReference

570674
kinetic law: 295573
product: 295561
product: 295548
reactant: 295536
fast: false
reversible: false
type: Reaction

560415
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 560155
type: Species

286693
stoichiometry: 1.0
species: 563755
type: SpeciesReference

570594
kinetic law: 295379
product: 295367
product: 295355
reactant: 295343
fast: false
reversible: false
type: Reaction

287729
local parameters: 051879
notes: k3*CaMKII_slash_tot_autonomous_CaMKII_slash_auton_305_slash_auton_305_cplx
type: KineticLaw

052371
units: 284709
value: 2.16E-15
type: LocalParameter

301877
stoichiometry: 1.0
species: 560435
type: SpeciesReference

052703
units: 284709
value: 1.7E-18
type: LocalParameter

285010
stoichiometry: 1.0
species: 560475
type: SpeciesReference

288080
stoichiometry: 1.0
species: 560635
type: SpeciesReference

293553
stoichiometry: 1.0
species: 565055
type: SpeciesReference

290037
stoichiometry: 1.0
species: 561355
type: SpeciesReference

285609
local parameters: 051741
local parameters: 051739
notes: kf*CaM_slash_CaM_minus_TR2_minus_Ca2_minus_PSD*Ca_minus_PSD-kb*CaM_slash_CaM_minus_Ca3_minus_PSD
type: KineticLaw

299811
stoichiometry: 1.0
species: 565035
type: SpeciesReference

052206
units: 284793
value: 2.011824E-17
type: LocalParameter

052743
units: 284709
value: 3.5E-18
type: LocalParameter

296069
stoichiometry: 1.0
species: 564715
type: SpeciesReference

052417
units: 284793
value: 3.5998992E-16
type: LocalParameter

570294
kinetic law: 294658
product: 294645
reactant: 294633
reactant: 294621
notes: #s from Bramson et al CRC crit rev Biochem 15:2 93-124. They have a huge list of peptide substrates and I have chosen high-ish rates. These consts give too much PKA activity, so lower Vmax 1/3. Now, k1 = 3e-5, k2 = 36, k3 = 9 (still pretty fast). Also lower Km 1/3 so k1 = 1e-5 Cohen et al FEBS Lett 76:182-86 1977 say rate =30% PKA act on phosphokinase beta.
fast: false
reversible: true
type: Reaction

295548
stoichiometry: 1.0
species: 564855
type: SpeciesReference

565035
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 560175
type: Species

567275
kinetic law: 287018
product: 287006
reactant: 286994
fast: false
reversible: true
type: Reaction

288634
stoichiometry: 1.0
species: 560755
type: SpeciesReference

568695
kinetic law: 290387
product: 290375
reactant: 290363
reactant: 290351
fast: false
reversible: true
type: Reaction

562335
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 560155
type: Species

289398
stoichiometry: 1.0
species: 565595
type: SpeciesReference

297622
stoichiometry: 1.0
species: 565075
type: SpeciesReference

572034
kinetic law: 298963
product: 298951
product: 298939
reactant: 298927
fast: false
reversible: false
type: Reaction

052041
units: 284709
value: 9.0E-16
type: LocalParameter

300342
stoichiometry: 1.0
species: 563755
type: SpeciesReference

288212
local parameters: 051904
notes: k3*CaMKII_slash_actCaMKII_minus_PSD_slash_CaMKII_sbo_1_sbc__slash_CaMKII_sbo_1_sbc__cplx
type: KineticLaw

052372
units: 284709
value: 5.4E-16
type: LocalParameter

285401
stoichiometry: 1.0
species: 560215
type: SpeciesReference

052702
units: 284709
value: 6.8E-18
type: LocalParameter

051747
units: 284709
value: 1.0E-17
type: LocalParameter

052374
units: 284793
value: 3.5998992E-16
type: LocalParameter

299230
stoichiometry: 1.0
species: 565155
type: SpeciesReference

052083
units: 284709
value: 3.06E-17
type: LocalParameter

294658
local parameters: 052326
local parameters: 052323
notes: k1*PP1_slash_I1*PKA_slash_PKA_minus_active-k2*PKA_slash_PKA_minus_active_slash_PKA_minus_phosph_minus_I1_slash_PKA_minus_phosph_minus_I1_cplx
type: KineticLaw

300052
stoichiometry: 1.0
species: 563755
type: SpeciesReference

292935
stoichiometry: 1.0
species: 565095
type: SpeciesReference

570834
kinetic law: 295961
product: 295949
product: 295936
reactant: 295924
fast: false
reversible: false
type: Reaction

562655
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 560155
type: Species

569534
kinetic law: 292812
product: 292800
reactant: 292788
reactant: 292776
fast: false
reversible: true
type: Reaction

052203
units: 284709
value: 1.8E-16
type: LocalParameter

564515
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.1
initial amount: NaN
in compartment: 560155
type: Species

286705
stoichiometry: 1.0
species: 563715
type: SpeciesReference

569294
kinetic law: 292031
product: 292019
reactant: 292007
reactant: 291995
fast: false
reversible: true
type: Reaction

052782
units: 284793
value: 8.7498E-18
type: LocalParameter

295476
local parameters: 052378
notes: k3*PKA_slash_PKA_minus_active_slash_PKA_sbo_22_sbc__slash_PKA_sbo_22_sbc__cplx
type: KineticLaw

572554
kinetic law: 300220
product: 300208
product: 300196
reactant: 300184
fast: false
reversible: false
type: Reaction

293346
local parameters: 052235
notes: k3*PP2B_slash_CaM_Ca_n_minus_CaNAB_slash_PP2B_sbo_4_sbc__slash_PP2B_sbo_4_sbc__cplx
type: KineticLaw

572594
kinetic law: 300318
product: 300306
product: 300294
reactant: 300281
fast: false
reversible: false
type: Reaction

287260
stoichiometry: 1.0
species: 565395
type: SpeciesReference

051744
units: 284709
value: 1.0E-16
type: LocalParameter

286632
stoichiometry: 1.0
species: 563735
type: SpeciesReference

285108
stoichiometry: 1.0
species: 560275
type: SpeciesReference

300645
stoichiometry: 1.0
species: 564235
type: SpeciesReference

566935
kinetic law: 286267
product: 286255
reactant: 286243
reactant: 286231
fast: false
reversible: true
type: Reaction

052082
units: 284709
value: 1.224E-16
type: LocalParameter

291042
stoichiometry: 1.0
species: 561675
type: SpeciesReference

290339
local parameters: 052036
notes: k3*PP1_slash_PP1_minus_active_slash_Deph_minus_thr286b_slash_Deph_minus_thr286b_cplx
type: KineticLaw

301527
local parameters: 052785
local parameters: 052782
notes: k1*AMPAR_memb_slash_A835_star_845_star__B835_star_845_star_*PP1_PSD_slash_PP1_minus_active_PSD-k2*PP1_PSD_slash_PP1_minus_active_PSD_slash_PP1_sbo_28_sbc__slash_PP1_sbo_28_sbc__cplx
type: KineticLaw

052044
units: 284709
value: 2.25E-16
type: LocalParameter

293664
stoichiometry: 1.0
species: 561675
type: SpeciesReference

569574
kinetic law: 292910
product: 292897
reactant: 292884
reactant: 292872
fast: false
reversible: true
type: Reaction

564955
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 560155
type: Species

301671
local parameters: 052797
notes: k3*PP1_PSD_slash_PP1_minus_active_PSD_slash_PP1_sbo_29_sbc__slash_PP1_sbo_29_sbc__cplx
type: KineticLaw

289034
local parameters: 051951
local parameters: 051948
notes: k1*AMPAR_memb_slash_A845_star__B831_star_*CaMKII_slash_actCaMKII_minus_PSD-k2*CaMKII_slash_actCaMKII_minus_PSD_slash_CaMKII_sbo_10_sbc__slash_CaMKII_sbo_10_sbc__cplx
type: KineticLaw

570874
kinetic law: 296057
product: 296045
product: 296033
reactant: 296021
fast: false
reversible: false
type: Reaction

297598
stoichiometry: 1.0
species: 562655
type: SpeciesReference

571654
kinetic law: 298043
product: 298031
reactant: 298019
reactant: 298007
notes: Best rates are from Conti et al Biochem 34 7979-7987 1995. Though these are for the Sertoli cell form, it looks like they carry nicely into alternatively spliced brain form. See Sette et al JBC 269:28 18271-18274 Km ~2 uM, Vmax est ~ 10 umol/min/mg for pure form. Brain protein is 93 kD but this was 67. So k3 ~10, k2 ~40, k1 ~4.2e-6
fast: false
reversible: true
type: Reaction

285755
stoichiometry: 1.0
species: 561175
type: SpeciesReference

051745
units: 284793
value: 3.0E-18
type: LocalParameter

294281
stoichiometry: 1.0
species: 562415
type: SpeciesReference

287321
local parameters: 051855
local parameters: 051853
notes: kf*AMPAR_memb_slash_GluR23_M-kb*AMPAR_slash_GluR23_I
type: KineticLaw

564995
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 560175
type: Species

290751
stoichiometry: 1.0
species: 561615
type: SpeciesReference

290291
local parameters: 052033
local parameters: 052031
notes: k1*CaMKII_slash_CaMKII_minus_thr286*PP1_slash_PP1_minus_active-k2*PP1_slash_PP1_minus_active_slash_Deph_minus_thr286b_slash_Deph_minus_thr286b_cplx
type: KineticLaw

052671
units: 284793
value: 8.7498E-18
type: LocalParameter

051814
units: 284709
value: 8.0E-21
type: LocalParameter

298758
stoichiometry: 1.0
species: 563755
type: SpeciesReference

294014
stoichiometry: 1.0
species: 561675
type: SpeciesReference

300572
stoichiometry: 1.0
species: 564215
type: SpeciesReference

051742
units: 284793
value: 4.65012E-18
type: LocalParameter

290146
local parameters: 052021
notes: k3*PP1_slash_PP2A_slash_PP2A_minus_dephosph_minus_PP1_minus_I_star__PSD_slash_PP2A_minus_dephosph_minus_PP1_minus_I_star__PSD_cplx
type: KineticLaw

299495
local parameters: 052643
local parameters: 052640
notes: k1*AMPAR_memb_slash_A831_star_845_star__B*PP1_PSD_slash_PP1_minus_active_PSD-k2*PP1_PSD_slash_PP1_minus_active_PSD_slash_PP1_sbo_7_sbc__slash_PP1_sbo_7_sbc__cplx
type: KineticLaw

567575
kinetic law: 287681
product: 287669
reactant: 287657
reactant: 287645
notes: See Hanson and Schulman again, for afterburst rates of phosph.
fast: false
reversible: true
type: Reaction

288320
stoichiometry: 1.0
species: 564975
type: SpeciesReference

288526
stoichiometry: 1.0
species: 565595
type: SpeciesReference

298565
stoichiometry: 1.0
species: 563755
type: SpeciesReference

299531
stoichiometry: 1.0
species: 563755
type: SpeciesReference

295718
local parameters: 052396
local parameters: 052393
notes: k1*AMPAR_slash_A831_star__B845_star_*PKA_slash_PKA_minus_active-k2*PKA_slash_PKA_minus_active_slash_PKA_sbo_25_sbc__slash_PKA_sbo_25_sbc__cplx
type: KineticLaw

302246
stoichiometry: 1.0
species: 563395
type: SpeciesReference

051703
units: 284709
value: 3.0E-18
type: LocalParameter

295658
stoichiometry: 1.0
species: 562655
type: SpeciesReference

571174
kinetic law: 296877
product: 296865
reactant: 296853
reactant: 296841
fast: false
reversible: true
type: Reaction

301140
local parameters: 052755
local parameters: 052753
notes: k1*AMPAR_memb_slash_A835_star_845_star__B835_star_845_star_*PP1_PSD_slash_PP1_minus_active_PSD-k2*PP1_PSD_slash_PP1_minus_active_PSD_slash_PP1_sbo_24_sbc__slash_PP1_sbo_24_sbc__cplx
type: KineticLaw

573454
kinetic law: 302414
product: 302402
reactant: 302390
reactant: 302378
notes: Rates are 60% those of PKC-phosph-neurogranin. See Huang et al ABB 305:2 570-580 1993
fast: false
reversible: true
type: Reaction

562695
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 560155
type: Species

300609
local parameters: 052716
notes: k3*PP1_PSD_slash_PP1_minus_active_PSD_slash_PP1_sbo_18_sbc__slash_PP1_sbo_18_sbc__cplx
type: KineticLaw

291320
stoichiometry: 1.0
species: 564695
type: SpeciesReference

052085
units: 284793
value: 3.0779838E-17
type: LocalParameter

291947
stoichiometry: 1.0
species: 561915
type: SpeciesReference

301080
stoichiometry: 1.0
species: 563755
type: SpeciesReference

571474
kinetic law: 297610
product: 297598
product: 297586
reactant: 297574
fast: false
reversible: false
type: Reaction

051790
units: 284793
value: 5.399946E-15
type: LocalParameter

292310
stoichiometry: 1.0
species: 561995
type: SpeciesReference

301767
local parameters: 052806
notes: k3*PP1_PSD_slash_PP1_minus_active_PSD_slash_PP1_sbo_30_sbc__slash_PP1_sbo_30_sbc__cplx
type: KineticLaw

052481
units: 284793
value: 3.999888E-17
type: LocalParameter

298794
stoichiometry: 1.0
species: 563755
type: SpeciesReference

293905
stoichiometry: 1.0
species: 565000
type: SpeciesReference

287370
stoichiometry: 1.0
species: 565435
type: SpeciesReference

052299
units: 284709
value: 1.8E-16
type: LocalParameter

567235
kinetic law: 286946
product: 286934
reactant: 286922
fast: false
reversible: true
type: Reaction

289313
stoichiometry: 1.0
species: 560895
type: SpeciesReference

571694
kinetic law: 298139
product: 298127
reactant: 298115
reactant: 298103
notes: This form has about twice the activity of the unphosphorylated form. See Sette et al JBC 269:28 18271-18274 1994. We\'ll ignore cGMP effects for now.
fast: false
reversible: true
type: Reaction

289241
stoichiometry: 1.0
species: 560875
type: SpeciesReference

290267
stoichiometry: 1.0
species: 561455
type: SpeciesReference

286415
local parameters: 051792
local parameters: 051790
notes: kf*PKA_slash_PKA_minus_active*PKA_slash_PKA_minus_inhibitor-kb*PKA_slash_inhibited_minus_PKA
type: KineticLaw

300451
stoichiometry: 1.0
species: 564195
type: SpeciesReference

297513
local parameters: 052510
notes: k3*PKA_slash_PKA_minus_active_slash_PKA_sbo_11_sbc__slash_PKA_sbo_11_sbc__cplx
type: KineticLaw

051813
units: 284709
value: 1.0E-18
type: LocalParameter

051898
units: 284709
value: 2.0E-17
type: LocalParameter

569295
kinetic law: 292079
product: 292067
product: 292055
reactant: 292043
fast: false
reversible: false
type: Reaction

285376
local parameters: 051726
local parameters: 051724
notes: kf*CaM_slash_CaM*Ca^2-kb*CaM_slash_CaM_minus_TR2_minus_Ca2
type: KineticLaw

051702
units: 284793
value: 5.4E-21
type: LocalParameter

566495
kinetic law: 285229
product: 285216
product: 285204
reactant: 285192
fast: false
reversible: true
type: Reaction

301344
stoichiometry: 1.0
species: 564375
type: SpeciesReference

291898
stoichiometry: 1.0
species: 564835
type: SpeciesReference

297327
stoichiometry: 1.0
species: 565000
type: SpeciesReference

302390
stoichiometry: 1.0
species: 564515
type: SpeciesReference

296670
stoichiometry: 1.0
species: 563115
type: SpeciesReference

052634
units: 284793
value: 8.7498E-18
type: LocalParameter

296816
stoichiometry: 1.0
species: 562655
type: SpeciesReference

293844
stoichiometry: 1.0
species: 565175
type: SpeciesReference

288562
stoichiometry: 1.0
species: 560735
type: SpeciesReference

293237
stoichiometry: 1.0
species: 561675
type: SpeciesReference

052088
units: 284709
value: 1.224E-16
type: LocalParameter

298674
local parameters: 052585
notes: k3*PP1_PSD_slash_PP1_minus_active_PSD_slash_Deph_minus_thr305_slash_Deph_minus_thr305_cplx
type: KineticLaw

300536
stoichiometry: 1.0
species: 563755
type: SpeciesReference

051899
units: 284709
value: 5.0E-18
type: LocalParameter

293008
local parameters: 052215
local parameters: 052212
notes: k1*AMPAR_memb_slash_A845_star__B845_star_*PP2B_slash_CaM_Ca_n_minus_CaNAB-k2*PP2B_slash_CaM_Ca_n_minus_CaNAB_slash_PP2B_sbo_1_sbc__slash_PP2B_sbo_1_sbc__cplx
type: KineticLaw

295367
stoichiometry: 1.0
species: 562655
type: SpeciesReference

288296
stoichiometry: 1.0
species: 565595
type: SpeciesReference

051816
units: 284793
value: 0.0
type: LocalParameter

569354
kinetic law: 292224
product: 292212
reactant: 292200
reactant: 292188
fast: false
reversible: true
type: Reaction

570434
kinetic law: 294994
product: 294982
product: 294970
reactant: 294958
fast: false
reversible: false
type: Reaction

287947
stoichiometry: 1.0
species: 565555
type: SpeciesReference

291705
stoichiometry: 1.0
species: 564735
type: SpeciesReference

562275
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 560155
type: Species

297034
stoichiometry: 1.0
species: 564995
type: SpeciesReference

292079
local parameters: 052150
notes: k3*PP2B_slash_CaM_Ca_n_minus_CaNAB_slash_PP2B_sbo_24_sbc__slash_PP2B_sbo_24_sbc__cplx
type: KineticLaw

286353
stoichiometry: 1.0
species: 562595
type: SpeciesReference

052529
units: 284709
value: 5.4E-16
type: LocalParameter

568375
kinetic law: 289616
product: 289604
reactant: 289592
reactant: 289580
fast: false
reversible: true
type: Reaction

052312
units: 284709
value: 2.403E-16
type: LocalParameter

294970
stoichiometry: 1.0
species: 564715
type: SpeciesReference

052631
units: 284709
value: 1.7E-18
type: LocalParameter

563535
constant: false
boundary condition: false
has only substance units: false
initial concentration: 2.59259259259259
initial amount: NaN
in compartment: 560155
type: Species

566715
kinetic law: 285743
product: 285731
reactant: 285719
notes: This is put in to keep the basal levels of neurogranin* experimentally reasonable. From various papers, specially Ramakers et al JBC 270:23 1995 13892-13898, it looks like the basal level of phosph is between 20 and 40%. I est around 25 % The kf of 0.005 gives around this level at basal PKC activity levels of 0.1 uM active PKC.
fast: false
reversible: true
type: Reaction

299387
stoichiometry: 1.0
species: 563975
type: SpeciesReference

285864
stoichiometry: 1.0
species: 561315
type: SpeciesReference

569355
kinetic law: 292273
product: 292261
product: 292249
reactant: 292236
fast: false
reversible: false
type: Reaction

287430
local parameters: 051864
local parameters: 051862
notes: kf*Ca_control_PSD-kb*Ca_minus_PSD
type: KineticLaw

565475
constant: false
boundary condition: true
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 560155
type: Species

294172
local parameters: 052291
local parameters: 052288
notes: k1*AMPAR_memb_slash_A835_star_845_star__B835_star_845_star_*PP2B_slash_CaM_Ca_n_minus_CaNAB-k2*PP2B_slash_CaM_Ca_n_minus_CaNAB_slash_PP2B_sbo_13_sbc__slash_PP2B_sbo_13_sbc__cplx
type: KineticLaw

290860
stoichiometry: 1.0
species: 561695
type: SpeciesReference

285486
stoichiometry: 1.0
species: 561035
type: SpeciesReference

568335
kinetic law: 289520
product: 289508
reactant: 289495
reactant: 289483
fast: false
reversible: true
type: Reaction

052674
units: 284709
value: 6.8E-18
type: LocalParameter

051741
units: 284709
value: 1.0E-16
type: LocalParameter

052528
units: 284709
value: 2.16E-15
type: LocalParameter

292285
stoichiometry: 1.0
species: 564795
type: SpeciesReference

294766
stoichiometry: 1.0
species: 562715
type: SpeciesReference

051700
units: 284709
value: 3.0E-18
type: LocalParameter

301296
stoichiometry: 1.0
species: 565075
type: SpeciesReference

568015
kinetic law: 288743
product: 288731
reactant: 288719
reactant: 288707
fast: false
reversible: true
type: Reaction

052313
units: 284709
value: 6.03E-17
type: LocalParameter

294826
stoichiometry: 1.0
species: 562655
type: SpeciesReference

291199
stoichiometry: 1.0
species: 561675
type: SpeciesReference

052484
units: 284709
value: 2.16E-15
type: LocalParameter

565875
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 560175
type: Species

288925
stoichiometry: 1.0
species: 560815
type: SpeciesReference

571134
kinetic law: 296780
product: 296768
reactant: 296756
reactant: 296744
fast: false
reversible: true
type: Reaction

567635
kinetic law: 287825
product: 287813
product: 287801
reactant: 287789
fast: false
reversible: false
type: Reaction

286303
stoichiometry: 1.0
species: 562575
type: SpeciesReference

298613
stoichiometry: 1.0
species: 563815
type: SpeciesReference

052261
units: 284793
value: 2.011824E-17
type: LocalParameter

296925
local parameters: 052471
notes: k3*PKA_slash_PKA_minus_active_slash_PKA_sbo_5_sbc__slash_PKA_sbo_5_sbc__cplx
type: KineticLaw

284853
exponent: 1.0
scale: -6
multipler: 1.0
kind: MOLE
type: SBMLUnit

292679
stoichiometry: 1.0
species: 564795
type: SpeciesReference

051893
units: 284709
value: 2.0E-17
type: LocalParameter

292535
stoichiometry: 1.0
species: 562035
type: SpeciesReference

052523
units: 284709
value: 5.4E-16
type: LocalParameter

289350
stoichiometry: 1.0
species: 565195
type: SpeciesReference

295815
local parameters: 052402
local parameters: 052399
notes: k1*AMPAR_slash_A_B831_star_845_star_*PKA_slash_PKA_minus_active-k2*PKA_slash_PKA_minus_active_slash_PKA_sbo_26_sbc__slash_PKA_sbo_26_sbc__cplx
type: KineticLaw

052485
units: 284709
value: 5.4E-16
type: LocalParameter

293384
stoichiometry: 1.0
species: 562235
type: SpeciesReference

571754
kinetic law: 298284
product: 298272
product: 298260
reactant: 298248
fast: false
reversible: false
type: Reaction

562715
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 560155
type: Species

052637
units: 284709
value: 6.8E-18
type: LocalParameter

564215
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 560175
type: Species

569115
kinetic law: 291404
product: 291392
product: 291380
reactant: 291368
fast: false
reversible: false
type: Reaction

292824
stoichiometry: 1.0
species: 562095
type: SpeciesReference

301200
stoichiometry: 1.0
species: 565195
type: SpeciesReference

051817
units: 284709
value: 8.0E-21
type: LocalParameter

293990
stoichiometry: 1.0
species: 562355
type: SpeciesReference

295694
stoichiometry: 1.0
species: 562655
type: SpeciesReference

571714
kinetic law: 298187
product: 298175
product: 298163
reactant: 298151
fast: false
reversible: false
type: Reaction

302282
stoichiometry: 1.0
species: 561115
type: SpeciesReference

289676
stoichiometry: 1.0
species: 560535
type: SpeciesReference

052089
units: 284709
value: 3.06E-17
type: LocalParameter

051894
units: 284709
value: 5.0E-18
type: LocalParameter

286994
stoichiometry: 1.0
species: 564775
type: SpeciesReference

051795
units: 284709
value: 9.0E-17
type: LocalParameter

052522
units: 284709
value: 2.16E-15
type: LocalParameter

052638
units: 284709
value: 1.7E-18
type: LocalParameter

288852
stoichiometry: 1.0
species: 560795
type: SpeciesReference

052677
units: 284709
value: 1.7E-18
type: LocalParameter

299279
stoichiometry: 1.0
species: 563755
type: SpeciesReference

287115
stoichiometry: 1.0
species: 564795
type: SpeciesReference

294862
stoichiometry: 1.0
species: 562735
type: SpeciesReference

296732
local parameters: 052457
notes: k3*PKA_slash_PKA_minus_active_slash_PKA_sbo_3_sbc__slash_PKA_sbo_3_sbc__cplx
type: KineticLaw

285535
stoichiometry: 2.0
species: 563655
type: SpeciesReference

567415
kinetic law: 287321
product: 287309
reactant: 287297
fast: false
reversible: true
type: Reaction

293092
stoichiometry: 1.0
species: 562175
type: SpeciesReference

051792
units: 284709
value: 9.0E-17
type: LocalParameter

290544
stoichiometry: 1.0
species: 560415
type: SpeciesReference

291681
stoichiometry: 1.0
species: 561675
type: SpeciesReference

052525
units: 284793
value: 3.999888E-17
type: LocalParameter

294123
local parameters: 052285
notes: k3*PP2B_slash_CaM_Ca_n_minus_CaNAB_slash_PP2B_sbo_12_sbc__slash_PP2B_sbo_12_sbc__cplx
type: KineticLaw

297947
local parameters: 052540
local parameters: 052537
notes: kcat*AC_slash_AC1_minus_CaM*AC_slash_ATP/(Km+AC_slash_ATP)
type: KineticLaw

295961
local parameters: 052409
notes: k3*PKA_slash_PKA_minus_active_slash_PKA_sbo_27_sbc__slash_PKA_sbo_27_sbc__cplx
type: KineticLaw

561555
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 560155
type: Species

291260
local parameters: 052100
local parameters: 052097
notes: k1*PP1_PSD_slash_PP1_minus_I1_star_*PP2B_slash_CaM_Ca_n_minus_CaNAB-k2*PP2B_slash_CaM_Ca_n_minus_CaNAB_slash_dephosph_minus_PP1_minus_I_star__PSD_slash_dephosph_minus_PP1_minus_I_star__PSD_cplx
type: KineticLaw

564095
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 560175
type: Species

051896
units: 284793
value: 2.77776E-19
type: LocalParameter

295066
stoichiometry: 1.0
species: 564895
type: SpeciesReference

051793
units: 284793
value: 4.4999712E-15
type: LocalParameter

570194
kinetic law: 294414
product: 294402
product: 294390
reactant: 294378
fast: false
reversible: false
type: Reaction

052488
units: 284793
value: 3.999888E-17
type: LocalParameter

293953
stoichiometry: 1.0
species: 561675
type: SpeciesReference

293044
stoichiometry: 1.0
species: 561675
type: SpeciesReference

052749
units: 284709
value: 1.4E-17
type: LocalParameter

051819
units: 284793
value: 0.0
type: LocalParameter

562055
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 560155
type: Species

292200
stoichiometry: 1.0
species: 561675
type: SpeciesReference

299315
stoichiometry: 1.0
species: 563955
type: SpeciesReference

295174
stoichiometry: 1.0
species: 562655
type: SpeciesReference

051799
units: 284709
value: 9.0E-19
type: LocalParameter

288104
stoichiometry: 1.0
species: 565595
type: SpeciesReference

284817
exponent: -1.0
scale: -6
multipler: 1.0
kind: MOLE
type: SBMLUnit

052253
units: 284709
value: 1.8E-16
type: LocalParameter

571294
kinetic law: 297167
product: 297155
reactant: 297143
reactant: 297131
fast: false
reversible: true
type: Reaction

300391
stoichiometry: 1.0
species: 565195
type: SpeciesReference

300813
stoichiometry: 1.0
species: 565235
type: SpeciesReference

290073
stoichiometry: 1.0
species: 561355
type: SpeciesReference

572814
kinetic law: 300849
product: 300837
reactant: 300825
reactant: 300813
fast: false
reversible: true
type: Reaction

302402
stoichiometry: 1.0
species: 564615
type: SpeciesReference

567175
kinetic law: 286814
product: 286801
product: 286789
reactant: 286777
fast: false
reversible: true
type: Reaction

052101
units: 284709
value: 3.06E-17
type: LocalParameter

565515
constant: false
boundary condition: false
has only substance units: false
initial concentration: 22.0
initial amount: NaN
in compartment: 560155
type: Species

285584
stoichiometry: 1.0
species: 563655
type: SpeciesReference

291151
stoichiometry: 1.0
species: 561755
type: SpeciesReference

052252
units: 284709
value: 7.2E-16
type: LocalParameter

572674
kinetic law: 300511
product: 300499
product: 300487
reactant: 300475
fast: false
reversible: false
type: Reaction

560136
constant: true
size: 1.0E-18
spatial dimensions: 3.0
type: Compartment

289495
stoichiometry: 1.0
species: 565595
type: SpeciesReference

286814
local parameters: 051819
local parameters: 051817
notes: kf*AMPAR_memb_slash_A_B831_star_-kb*AMPAR_slash_A_B831_star_*AMPAR_memb_slash_Anchor
type: KineticLaw

052190
units: 284709
value: 1.8E-16
type: LocalParameter

292643
stoichiometry: 1.0
species: 564715
type: SpeciesReference

293480
stoichiometry: 1.0
species: 562255
type: SpeciesReference

295138
local parameters: 052359
local parameters: 052356
notes: k1*AMPAR_slash_A831_star__B831_star_*PKA_slash_PKA_minus_active-k2*PKA_slash_PKA_minus_active_slash_PKA_sbo_19_sbc__slash_PKA_sbo_19_sbc__cplx
type: KineticLaw

051798
units: 284709
value: 0.0
type: LocalParameter

567135
kinetic law: 286717
product: 286705
reactant: 286693
reactant: 286681
notes: K inhib = 1nM from Cohen Ann Rev Bioch 1989, 4 nM from Foukes et al Assume 2 nM. kf /kb = 8.333e-4
fast: false
reversible: true
type: Reaction

563755
constant: false
boundary condition: false
has only substance units: false
initial concentration: 4.0
initial amount: NaN
in compartment: 560175
type: Species

300269
local parameters: 052696
local parameters: 052693
notes: k1*AMPAR_memb_slash_A845_star__B831_star_*PP1_PSD_slash_PP1_minus_active_PSD-k2*PP1_PSD_slash_PP1_minus_active_PSD_slash_PP1_sbo_15_sbc__slash_PP1_sbo_15_sbc__cplx
type: KineticLaw

052100
units: 284709
value: 1.224E-16
type: LocalParameter

300909
stoichiometry: 1.0
species: 565115
type: SpeciesReference

296454
stoichiometry: 1.0
species: 565035
type: SpeciesReference

051971
units: 284709
value: 2.0E-17
type: LocalParameter

568535
kinetic law: 290001
product: 289989
reactant: 289977
reactant: 289965
notes: PP2A does most of the dephosph of I1 at basal Ca levels. See the review by Cohen in Ann Rev Biochem 1989. For now, lets halve Km. k1 was 3.3e-6, now 6.6e-6
fast: false
reversible: true
type: Reaction

572334
kinetic law: 299689
product: 299676
reactant: 299664
reactant: 299652
fast: false
reversible: true
type: Reaction

052453
units: 284793
value: 3.999888E-17
type: LocalParameter

296129
stoichiometry: 1.0
species: 564775
type: SpeciesReference

298031
stoichiometry: 1.0
species: 563475
type: SpeciesReference

296526
stoichiometry: 1.0
species: 562655
type: SpeciesReference

565375
constant: true
boundary condition: true
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 560155
type: Species

295030
stoichiometry: 1.0
species: 562775
type: SpeciesReference

287849
stoichiometry: 1.0
species: 565555
type: SpeciesReference

567755
kinetic law: 288116
product: 288104
product: 288092
reactant: 288080
fast: false
reversible: false
type: Reaction

568835
kinetic law: 290726
product: 290713
product: 290701
reactant: 290689
fast: false
reversible: false
type: Reaction

302126
stoichiometry: 1.0
species: 564555
type: SpeciesReference

288804
stoichiometry: 1.0
species: 565235
type: SpeciesReference

289520
local parameters: 051976
local parameters: 051974
notes: k1*AMPAR_memb_slash_A831_star__B*CaMKII_slash_actCaMKII_minus_PSD-k2*CaMKII_slash_actCaMKII_minus_PSD_slash_CaMKII_sbo_15_sbc__slash_CaMKII_sbo_15_sbc__cplx
type: KineticLaw

568775
kinetic law: 290581
product: 290568
reactant: 290556
reactant: 290544
fast: false
reversible: true
type: Reaction

294548
stoichiometry: 1.0
species: 562675
type: SpeciesReference

293724
stoichiometry: 1.0
species: 561675
type: SpeciesReference

572374
kinetic law: 299787
product: 299774
reactant: 299762
reactant: 299749
fast: false
reversible: true
type: Reaction

051972
units: 284709
value: 5.0E-18
type: LocalParameter

571254
kinetic law: 297071
product: 297058
reactant: 297046
reactant: 297034
fast: false
reversible: true
type: Reaction

052212
units: 284793
value: 2.011824E-17
type: LocalParameter

287212
stoichiometry: 1.0
species: 564755
type: SpeciesReference

052456
units: 284709
value: 2.16E-15
type: LocalParameter

298975
stoichiometry: 1.0
species: 565035
type: SpeciesReference

563435
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 560155
type: Species

289712
local parameters: 051992
local parameters: 051990
notes: k1*CaMKII_slash_CaMKII_minus_CaM_minus_PSD*CaMKII_slash_tot_minus_CaM_minus_CaMKII_minus_PSD-k2*CaMKII_slash_tot_minus_CaM_minus_CaMKII_minus_PSD_slash_CaM_minus_act_minus_286_minus_PSD_slash_CaM_minus_act_minus_286_minus_PSD_cplx
type: KineticLaw

571974
kinetic law: 298818
product: 298806
reactant: 298794
reactant: 298782
fast: false
reversible: true
type: Reaction

293444
local parameters: 052241
notes: k3*PP2B_slash_CaM_Ca_n_minus_CaNAB_slash_PP2B_sbo_5_sbc__slash_PP2B_sbo_5_sbc__cplx
type: KineticLaw

286097
stoichiometry: 1.0
species: 563635
type: SpeciesReference

568435
kinetic law: 289760
product: 289748
product: 289736
reactant: 289724
fast: false
reversible: false
type: Reaction

051796
units: 284709
value: 9.0E-18
type: LocalParameter

573234
kinetic law: 301864
product: 301852
product: 301840
reactant: 301828
fast: false
reversible: false
type: Reaction

285719
stoichiometry: 1.0
species: 561135
type: SpeciesReference

286910
local parameters: 051825
local parameters: 051823
notes: kf*AMPAR_memb_slash_A_B-kb*AMPAR_slash_A_B*AMPAR_memb_slash_Anchor
type: KineticLaw

291428
stoichiometry: 1.0
species: 561675
type: SpeciesReference

300318
local parameters: 052697
notes: k3*PP1_PSD_slash_PP1_minus_active_PSD_slash_PP1_sbo_15_sbc__slash_PP1_sbo_15_sbc__cplx
type: KineticLaw

051820
units: 284709
value: 8.0E-21
type: LocalParameter

287151
local parameters: 051843
local parameters: 051841
notes: kf*AMPAR_slash_A845_star__B831_star_845_star_*AMPAR_memb_slash_Anchor-kb*AMPAR_memb_slash_A845_star__B831_star_845_star_
type: KineticLaw

051891
units: 284793
value: 1.99998E-19
type: LocalParameter

570374
kinetic law: 294850
product: 294838
reactant: 294826
reactant: 294814
fast: false
reversible: true
type: Reaction

288780
stoichiometry: 1.0
species: 565595
type: SpeciesReference

570334
kinetic law: 294754
product: 294742
reactant: 294730
reactant: 294718
fast: false
reversible: true
type: Reaction

295246
stoichiometry: 1.0
species: 562815
type: SpeciesReference

052842
units: 284709
value: 3.15E-17
type: LocalParameter

562915
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 560155
type: Species

565295
constant: false
boundary condition: false
has only substance units: false
initial concentration: 27.3333333333333
initial amount: NaN
in compartment: 560175
type: Species

052319
units: 284709
value: 3.24E-15
type: LocalParameter

567815
kinetic law: 288260
product: 288248
reactant: 288236
reactant: 288224
fast: false
reversible: true
type: Reaction

285265
stoichiometry: 1.0
species: 560535
type: SpeciesReference

561715
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 560155
type: Species

573054
kinetic law: 301430
product: 301418
reactant: 301405
reactant: 301393
fast: false
reversible: true
type: Reaction

296418
stoichiometry: 1.0
species: 565135
type: SpeciesReference

298456
stoichiometry: 1.0
species: 560535
type: SpeciesReference

052630
units: 284709
value: 6.8E-18
type: LocalParameter

289459
stoichiometry: 1.0
species: 565595
type: SpeciesReference

301943
stoichiometry: 1.0
species: 560475
type: SpeciesReference

287596
stoichiometry: 1.0
species: 560355
type: SpeciesReference

299060
local parameters: 052611
notes: k3*PP1_PSD_slash_PP1_minus_active_PSD_slash_PP1_sbo_2_sbc__slash_PP1_sbo_2_sbc__cplx
type: KineticLaw

051862
units: 284709
value: 1.0E-15
type: LocalParameter

569994
kinetic law: 293929
product: 293917
product: 293905
reactant: 293893
fast: false
reversible: false
type: Reaction

052218
units: 284793
value: 2.011824E-17
type: LocalParameter

292752
stoichiometry: 1.0
species: 561675
type: SpeciesReference

571214
kinetic law: 296974
product: 296962
reactant: 296950
reactant: 296937
fast: false
reversible: true
type: Reaction

287504
stoichiometry: 1.0
species: 560295
type: SpeciesReference

295754
stoichiometry: 1.0
species: 562655
type: SpeciesReference

302090
stoichiometry: 1.0
species: 564515
type: SpeciesReference

299423
stoichiometry: 1.0
species: 564995
type: SpeciesReference

301044
local parameters: 052749
local parameters: 052746
notes: k1*AMPAR_memb_slash_A_B831_star_*PP1_PSD_slash_PP1_minus_active_PSD-k2*PP1_PSD_slash_PP1_minus_active_PSD_slash_PP1_sbo_23_sbc__slash_PP1_sbo_23_sbc__cplx
type: KineticLaw

290472
stoichiometry: 1.0
species: 561535
type: SpeciesReference

286391
stoichiometry: 1.0
species: 562615
type: SpeciesReference

302342
stoichiometry: 1.0
species: 561135
type: SpeciesReference

301393
stoichiometry: 1.0
species: 565015
type: SpeciesReference

561775
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 560155
type: Species

288140
stoichiometry: 1.0
species: 565595
type: SpeciesReference

289132
local parameters: 051956
local parameters: 051954
notes: k1*AMPAR_memb_slash_A_B831_star_*CaMKII_slash_actCaMKII_minus_PSD-k2*CaMKII_slash_actCaMKII_minus_PSD_slash_CaMKII_sbo_11_sbc__slash_CaMKII_sbo_11_sbc__cplx
type: KineticLaw

290110
stoichiometry: 1.0
species: 561435
type: SpeciesReference

290219
stoichiometry: 1.0
species: 560255
type: SpeciesReference

568595
kinetic law: 290146
product: 290134
product: 290122
reactant: 290110
fast: false
reversible: false
type: Reaction

292703
stoichiometry: 1.0
species: 562075
type: SpeciesReference

052258
units: 284709
value: 7.2E-16
type: LocalParameter

051861
units: 284709
value: 9.0E-15
type: LocalParameter

297488
stoichiometry: 1.0
species: 565115
type: SpeciesReference

293590
local parameters: 052252
local parameters: 052249
notes: k1*AMPAR_memb_slash_A831_star_845_star__B*PP2B_slash_CaM_Ca_n_minus_CaNAB-k2*PP2B_slash_CaM_Ca_n_minus_CaNAB_slash_PP2B_sbo_7_sbc__slash_PP2B_sbo_7_sbc__cplx
type: KineticLaw

051822
units: 284793
value: 0.0
type: LocalParameter

573014
kinetic law: 301332
product: 301320
reactant: 301308
reactant: 301296
fast: false
reversible: true
type: Reaction

052457
units: 284709
value: 5.4E-16
type: LocalParameter

301647
stoichiometry: 1.0
species: 565155
type: SpeciesReference

301903
stoichiometry: 1.0
species: 564495
type: SpeciesReference

301032
stoichiometry: 1.0
species: 564315
type: SpeciesReference

562615
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.259259259259259
initial amount: NaN
in compartment: 560155
type: Species

290811
stoichiometry: 1.0
species: 561615
type: SpeciesReference

291464
stoichiometry: 1.0
species: 561815
type: SpeciesReference

301982
stoichiometry: 1.0
species: 561055
type: SpeciesReference

302450
stoichiometry: 1.0
species: 561135
type: SpeciesReference

287556
stoichiometry: 1.0
species: 565475
type: SpeciesReference

290763
stoichiometry: 1.0
species: 561655
type: SpeciesReference

051864
units: 284709
value: 1.0E-15
type: LocalParameter

286898
stoichiometry: 1.0
species: 565295
type: SpeciesReference

052255
units: 284793
value: 2.011824E-17
type: LocalParameter

286536
local parameters: 051801
local parameters: 051799
notes: kf*AC_slash_cAMP_minus_PDE_star_-kb*AC_slash_cAMP_minus_PDE
type: KineticLaw

288466
stoichiometry: 1.0
species: 560715
type: SpeciesReference

288974
stoichiometry: 1.0
species: 565595
type: SpeciesReference

573154
kinetic law: 301671
product: 301659
product: 301647
reactant: 301635
fast: false
reversible: false
type: Reaction

051823
units: 284709
value: 8.0E-21
type: LocalParameter

293261
stoichiometry: 1.0
species: 565215
type: SpeciesReference

052216
units: 284709
value: 1.8E-16
type: LocalParameter

052491
units: 284709
value: 2.16E-15
type: LocalParameter

297143
stoichiometry: 1.0
species: 562655
type: SpeciesReference

291753
stoichiometry: 1.0
species: 561875
type: SpeciesReference

292188
stoichiometry: 1.0
species: 564775
type: SpeciesReference

297670
stoichiometry: 1.0
species: 563315
type: SpeciesReference

294354
stoichiometry: 1.0
species: 562435
type: SpeciesReference

289869
stoichiometry: 1.0
species: 561315
type: SpeciesReference

564155
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 560175
type: Species

573194
kinetic law: 301767
product: 301755
product: 301743
reactant: 301731
fast: false
reversible: false
type: Reaction

300897
local parameters: 052737
notes: k3*PP1_PSD_slash_PP1_minus_active_PSD_slash_PP1_sbo_21_sbc__slash_PP1_sbo_21_sbc__cplx
type: KineticLaw

052316
units: 284793
value: 5.399946E-16
type: LocalParameter

571814
kinetic law: 298431
product: 298419
reactant: 298406
reactant: 298394
fast: false
reversible: true
type: Reaction

297875
stoichiometry: 1.0
species: 565075
type: SpeciesReference

567355
kinetic law: 287200
product: 287188
reactant: 287175
reactant: 287163
fast: false
reversible: true
type: Reaction

299134
stoichiometry: 1.0
species: 564975
type: SpeciesReference

299713
stoichiometry: 1.0
species: 565095
type: SpeciesReference

292249
stoichiometry: 1.0
species: 564955
type: SpeciesReference

285450
stoichiometry: 1.0
species: 560995
type: SpeciesReference

302162
stoichiometry: 1.0
species: 564515
type: SpeciesReference

573114
kinetic law: 301575
product: 301563
product: 301551
reactant: 301539
fast: false
reversible: false
type: Reaction

301248
stoichiometry: 1.0
species: 564355
type: SpeciesReference

286243
stoichiometry: 1.0
species: 562535
type: SpeciesReference

564555
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 560155
type: Species

292176
local parameters: 052157
notes: k3*PP2B_slash_CaM_Ca_n_minus_CaNAB_slash_PP2B_sbo_25_sbc__slash_PP2B_sbo_25_sbc__cplx
type: KineticLaw

052215
units: 284709
value: 7.2E-16
type: LocalParameter

569634
kinetic law: 293056
product: 293044
product: 293032
reactant: 293020
fast: false
reversible: false
type: Reaction

560315
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 560155
type: Species

290581
local parameters: 052058
local parameters: 052055
notes: k1*CaMKII_slash_CaMK_minus_thr305*PP1_slash_PP1_minus_active-k2*PP1_slash_PP1_minus_active_slash_Deph_minus_thr305a_slash_Deph_minus_thr305a_cplx
type: KineticLaw

299980
local parameters: 052674
local parameters: 052671
notes: k1*AMPAR_memb_slash_A845_star__B831_star_845_star_*PP1_PSD_slash_PP1_minus_active_PSD-k2*PP1_PSD_slash_PP1_minus_active_PSD_slash_PP1_sbo_12_sbc__slash_PP1_sbo_12_sbc__cplx
type: KineticLaw

567675
kinetic law: 287922
product: 287910
product: 287898
reactant: 287886
fast: false
reversible: false
type: Reaction

052109
units: 284793
value: 1.8106416E-16
type: LocalParameter

289568
local parameters: 051979
notes: k3*CaMKII_slash_actCaMKII_minus_PSD_slash_CaMKII_sbo_15_sbc__slash_CaMKII_sbo_15_sbc__cplx
type: KineticLaw

565835
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 560175
type: Species

573414
kinetic law: 302318
product: 302306
reactant: 302294
reactant: 302282
notes: Rates from Huang et al ABB 305:2 570-580 1993
fast: false
reversible: true
type: Reaction

293517
stoichiometry: 1.0
species: 564995
type: SpeciesReference

288032
stoichiometry: 1.0
species: 565135
type: SpeciesReference

298079
stoichiometry: 1.0
species: 563455
type: SpeciesReference

296309
stoichiometry: 1.0
species: 563035
type: SpeciesReference

052197
units: 284709
value: 1.8E-16
type: LocalParameter

300789
stoichiometry: 1.0
species: 563755
type: SpeciesReference

566555
kinetic law: 285376
product: 285364
reactant: 285352
reactant: 285340
notes: Lets use the fast rate consts here. Since the rates are so different, I am not sure whether the order is relevant. These correspond to the TR2C fragment. We use the Martin et al rates here, plus the Drabicowski binding consts. All are scaled by 3X to cell temp. kf = 2e-10 kb = 72 Stemmer & Klee: K1=.9, K2=1.1. Assume 1.0uM for both. kb/kf=3.6e11. If kb=72, kf = 2e-10 (Exactly the same !)....
fast: false
reversible: true
type: Reaction

052199
units: 284793
value: 1.8106416E-16
type: LocalParameter

051929
units: 284709
value: 2.0E-17
type: LocalParameter

291645
local parameters: 052124
local parameters: 052121
notes: k1*AMPAR_slash_A831_star_845_star__B831_star_*PP2B_slash_CaM_Ca_n_minus_CaNAB-k2*PP2B_slash_CaM_Ca_n_minus_CaNAB_slash_PP2B_sbo_20_sbc__slash_PP2B_sbo_20_sbc__cplx
type: KineticLaw

299920
stoichiometry: 1.0
species: 563755
type: SpeciesReference

297379
stoichiometry: 1.0
species: 563255
type: SpeciesReference

569834
kinetic law: 293541
product: 293529
product: 293517
reactant: 293505
fast: false
reversible: false
type: Reaction

052566
units: 284709
value: 9.0E-16
type: LocalParameter

297839
stoichiometry: 1.0
species: 563355
type: SpeciesReference

291223
stoichiometry: 1.0
species: 563715
type: SpeciesReference

051979
units: 284709
value: 5.0E-18
type: LocalParameter

295646
stoichiometry: 1.0
species: 564755
type: SpeciesReference

569314
kinetic law: 292128
product: 292116
reactant: 292103
reactant: 292091
fast: false
reversible: true
type: Reaction

560355
constant: false
boundary condition: false
has only substance units: false
initial concentration: 2.44537037037037E-8
initial amount: NaN
in compartment: 560155
type: Species

291091
stoichiometry: 1.0
species: 561335
type: SpeciesReference

052033
units: 284709
value: 9.0E-16
type: LocalParameter

291959
stoichiometry: 1.0
species: 564875
type: SpeciesReference

296634
local parameters: 052451
notes: k3*PKA_slash_PKA_minus_active_slash_PKA_sbo_2_sbc__slash_PKA_sbo_2_sbc__cplx
type: KineticLaw

052149
units: 284709
value: 7.2E-16
type: LocalParameter

299170
stoichiometry: 1.0
species: 565215
type: SpeciesReference

051865
units: 284793
value: 2.3767344E-17
type: LocalParameter

052209
units: 284709
value: 7.2E-16
type: LocalParameter

290701
stoichiometry: 1.0
species: 561275
type: SpeciesReference

292499
stoichiometry: 1.0
species: 561675
type: SpeciesReference

290001
local parameters: 052014
local parameters: 052011
notes: k1*PP1_PSD_slash_I1_star_*PP1_slash_PP2A-k2*PP1_slash_PP2A_slash_PP2A_minus_dephosph_minus_I1_PSD_slash_PP2A_minus_dephosph_minus_I1_PSD_cplx
type: KineticLaw

294694
stoichiometry: 1.0
species: 562655
type: SpeciesReference

294463
local parameters: 052312
local parameters: 052309
notes: k1*CaM_slash_neurogranin_star__PSD*PP2B_slash_CaM_Ca_n_minus_CaNAB-k2*PP2B_slash_CaM_Ca_n_minus_CaNAB_slash_dephosph_neurogranin_PSD_slash_dephosph_neurogranin_PSD_cplx
type: KineticLaw

564335
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 560175
type: Species

562395
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 560155
type: Species

302054
stoichiometry: 1.0
species: 564515
type: SpeciesReference

052107
units: 284709
value: 1.8E-16
type: LocalParameter

052036
units: 284709
value: 2.25E-16
type: LocalParameter

293153
local parameters: 052222
notes: k3*PP2B_slash_CaM_Ca_n_minus_CaNAB_slash_PP2B_sbo_2_sbc__slash_PP2B_sbo_2_sbc__cplx
type: KineticLaw

287996
stoichiometry: 1.0
species: 560555
type: SpeciesReference

052259
units: 284709
value: 1.8E-16
type: LocalParameter

052146
units: 284793
value: 1.8106416E-16
type: LocalParameter

286741
stoichiometry: 1.0
species: 564915
type: SpeciesReference

297767
stoichiometry: 1.0
species: 563335
type: SpeciesReference

560975
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 560175
type: Species

289941
stoichiometry: 1.0
species: 561355
type: SpeciesReference

291573
stoichiometry: 1.0
species: 564875
type: SpeciesReference

051868
units: 284709
value: 5.4E-16
type: LocalParameter

569394
kinetic law: 292375
product: 292362
product: 292349
reactant: 292336
fast: false
reversible: false
type: Reaction

286958
stoichiometry: 1.0
species: 564795
type: SpeciesReference

560395
constant: false
boundary condition: false
has only substance units: false
initial concentration: 1.89444444444444E-5
initial amount: NaN
in compartment: 560155
type: Species

300160
stoichiometry: 1.0
species: 564135
type: SpeciesReference

294500
stoichiometry: 1.0
species: 561675
type: SpeciesReference

301418
stoichiometry: 1.0
species: 564395
type: SpeciesReference

052106
units: 284709
value: 7.2E-16
type: LocalParameter

297440
stoichiometry: 1.0
species: 562655
type: SpeciesReference

052381
units: 284793
value: 3.5998992E-16
type: LocalParameter

298115
stoichiometry: 1.0
species: 563495
type: SpeciesReference

297562
local parameters: 052516
local parameters: 052513
notes: k1*AMPAR_memb_slash_A831_star__B831_star_845_star_*PKA_slash_PKA_minus_active-k2*PKA_slash_PKA_minus_active_slash_PKA_sbo_12_sbc__slash_PKA_sbo_12_sbc__cplx
type: KineticLaw

560935
constant: false
boundary condition: false
has only substance units: false
initial concentration: 1.02566666666667E-215
initial amount: NaN
in compartment: 560175
type: Species

568055
kinetic law: 288840
product: 288828
reactant: 288816
reactant: 288804
fast: false
reversible: true
type: Reaction

294922
stoichiometry: 1.0
species: 562655
type: SpeciesReference

052568
units: 284793
value: 6.2502E-17
type: LocalParameter

285963
stoichiometry: 1.0
species: 561615
type: SpeciesReference

287801
stoichiometry: 1.0
species: 560275
type: SpeciesReference

571594
kinetic law: 297899
product: 297887
product: 297875
reactant: 297863
fast: false
reversible: false
type: Reaction

564375
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 560175
type: Species

566755
kinetic law: 285827
product: 285815
reactant: 285803
notes: Diffusional equilibrium between PSD- and cytosolic compartment. According to D. Bary in Cell Movements 2nd ed 2001 D for proteins is 5e-7 cm^2/s giving 10 ms for a translocation of 1 um.
fast: false
reversible: true
type: Reaction

289082
local parameters: 051952
notes: k3*CaMKII_slash_actCaMKII_minus_PSD_slash_CaMKII_sbo_10_sbc__slash_CaMKII_sbo_10_sbc__cplx
type: KineticLaw

562975
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 560155
type: Species

288574
stoichiometry: 1.0
species: 565175
type: SpeciesReference

051927
units: 284793
value: 2.77776E-19
type: LocalParameter

571554
kinetic law: 297803
product: 297791
product: 297779
reactant: 297767
fast: false
reversible: false
type: Reaction

290653
stoichiometry: 1.0
species: 561615
type: SpeciesReference

562355
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 560155
type: Species

051867
units: 284709
value: 2.16E-15
type: LocalParameter

296237
stoichiometry: 1.0
species: 562655
type: SpeciesReference

298187
local parameters: 052553
notes: k3*AC_slash_cAMP_minus_PDE_star__slash_PDE_star__slash_PDE_star__cplx
type: KineticLaw

297404
stoichiometry: 1.0
species: 562655
type: SpeciesReference

288188
stoichiometry: 1.0
species: 565155
type: SpeciesReference

287657
stoichiometry: 1.0
species: 565495
type: SpeciesReference

561995
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 560155
type: Species

052210
units: 284709
value: 1.8E-16
type: LocalParameter

051974
units: 284793
value: 2.77776E-19
type: LocalParameter

052193
units: 284793
value: 1.8106416E-16
type: LocalParameter

564055
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 560175
type: Species

051924
units: 284709
value: 2.0E-17
type: LocalParameter

285827
local parameters: 051756
local parameters: 051754
notes: kf*CaM_slash_CaM_minus_Ca4_minus_PSD-kb*CaM_slash_CaM_minus_Ca4
type: KineticLaw

052144
units: 284709
value: 1.8E-16
type: LocalParameter

565135
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 560175
type: Species

298939
stoichiometry: 1.0
species: 565035
type: SpeciesReference

293408
stoichiometry: 1.0
species: 562235
type: SpeciesReference

052562
units: 284793
value: 1.1339838E-16
type: LocalParameter

052788
units: 284709
value: 3.5E-18
type: LocalParameter

561595
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 560155
type: Species

285328
local parameters: 051723
local parameters: 051721
notes: kf*CaMKII_slash_CaMKII_minus_thr286_minus_PSD*CaM_slash_CaM_minus_Ca4_minus_PSD-kb*CaMKII_slash_CaMKII_minus_thr286_minus_CaM_minus_PSD
type: KineticLaw

289192
stoichiometry: 1.0
species: 565215
type: SpeciesReference

052848
units: 284709
value: 1.44E-15
type: LocalParameter

290183
stoichiometry: 1.0
species: 561475
type: SpeciesReference

570774
kinetic law: 295815
product: 295802
reactant: 295790
reactant: 295778
fast: false
reversible: true
type: Reaction

298516
stoichiometry: 1.0
species: 563795
type: SpeciesReference

289410
stoichiometry: 1.0
species: 560915
type: SpeciesReference

300112
stoichiometry: 1.0
species: 563755
type: SpeciesReference

051925
units: 284709
value: 5.0E-18
type: LocalParameter

292414
stoichiometry: 1.0
species: 562015
type: SpeciesReference

285695
stoichiometry: 1.0
species: 561095
type: SpeciesReference

284889
stoichiometry: 1.0
species: 560255
type: SpeciesReference

286133
stoichiometry: 1.0
species: 562495
type: SpeciesReference

301308
stoichiometry: 1.0
species: 563755
type: SpeciesReference

284925
stoichiometry: 1.0
species: 561255
type: SpeciesReference

562435
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 560155
type: Species

569654
kinetic law: 293104
product: 293092
reactant: 293080
reactant: 293068
fast: false
reversible: true
type: Reaction

052565
units: 284709
value: 3.6E-15
type: LocalParameter

051976
units: 284709
value: 2.0E-17
type: LocalParameter

296346
local parameters: 052433
notes: k3*PKA_slash_PKA_minus_active_slash_PKA_sbo_31_sbc__slash_PKA_sbo_31_sbc__cplx
type: KineticLaw

052845
units: 284793
value: 5.399946E-17
type: LocalParameter

052103
units: 284793
value: 1.8106416E-16
type: LocalParameter

291536
stoichiometry: 1.0
species: 561835
type: SpeciesReference

297083
stoichiometry: 1.0
species: 563195
type: SpeciesReference

289205
stoichiometry: 1.0
species: 565595
type: SpeciesReference

563695
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 560175
type: Species

288405
local parameters: 051915
notes: k3*CaMKII_slash_actCaMKII_minus_PSD_slash_CaMKII_sbo_3_sbc__slash_CaMKII_sbo_3_sbc__cplx
type: KineticLaw

286463
local parameters: 051795
local parameters: 051793
notes: kf*CaM_slash_CaM_minus_Ca4*AC_slash_AC1-kb*AC_slash_AC1_minus_CaM
type: KineticLaw

052411
units: 284793
value: 3.5998992E-16
type: LocalParameter

051922
units: 284793
value: 2.77776E-19
type: LocalParameter

294439
stoichiometry: 1.0
species: 561675
type: SpeciesReference

298224
stoichiometry: 1.0
species: 563555
type: SpeciesReference

289820
stoichiometry: 1.0
species: 561375
type: SpeciesReference

296998
stoichiometry: 1.0
species: 565155
type: SpeciesReference

560635
constant: false
boundary condition: false
has only substance units: false
initial concentration: 7.1375E-215
initial amount: NaN
in compartment: 560175
type: Species

301454
stoichiometry: 1.0
species: 565000
type: SpeciesReference

300220
local parameters: 052690
notes: k3*PP1_PSD_slash_PP1_minus_active_PSD_slash_PP1_sbo_14_sbc__slash_PP1_sbo_14_sbc__cplx
type: KineticLaw

297071
local parameters: 052484
local parameters: 052481
notes: k1*AMPAR_memb_slash_A831_star__B*PKA_slash_PKA_minus_active-k2*PKA_slash_PKA_minus_active_slash_PKA_sbo_7_sbc__slash_PKA_sbo_7_sbc__cplx
type: KineticLaw

285059
stoichiometry: 1.0
species: 560255
type: SpeciesReference

570154
kinetic law: 294318
product: 294306
product: 294294
reactant: 294281
fast: false
reversible: false
type: Reaction

052451
units: 284709
value: 5.4E-16
type: LocalParameter

298382
local parameters: 052566
notes: k3*AC_slash_CaM_dot_PDE1_slash_CaM_dot_PDE1_slash_CaM_dot_PDE1_cplx
type: KineticLaw

287042
stoichiometry: 1.0
species: 565375
type: SpeciesReference

290980
stoichiometry: 1.0
species: 561715
type: SpeciesReference

294062
stoichiometry: 1.0
species: 562375
type: SpeciesReference

287102
local parameters: 051840
local parameters: 051838
notes: kf*AMPAR_slash_A835_star_845_star__B835_star_845_star_*AMPAR_memb_slash_Anchor-kb*AMPAR_memb_slash_A835_star_845_star__B835_star_845_star_
type: KineticLaw

286850
stoichiometry: 1.0
species: 565295
type: SpeciesReference

300427
stoichiometry: 1.0
species: 565255
type: SpeciesReference

052196
units: 284709
value: 7.2E-16
type: LocalParameter

285192
stoichiometry: 1.0
species: 560535
type: SpeciesReference

300705
local parameters: 052723
notes: k3*PP1_PSD_slash_PP1_minus_active_PSD_slash_PP1_sbo_19_sbc__slash_PP1_sbo_19_sbc__cplx
type: KineticLaw

297203
stoichiometry: 1.0
species: 562655
type: SpeciesReference

562015
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 560155
type: Species

299640
local parameters: 052650
notes: k3*PP1_PSD_slash_PP1_minus_active_PSD_slash_PP1_sbo_8_sbc__slash_PP1_sbo_8_sbc__cplx
type: KineticLaw

052450
units: 284709
value: 2.16E-15
type: LocalParameter

296021
stoichiometry: 1.0
species: 562975
type: SpeciesReference

302018
local parameters: 052830
local parameters: 052827
notes: k1*CaM_slash_neurogranin*PKC_minus_active-k2*PKC_minus_active_slash_PKC_minus_phosph_minus_neurogranin_slash_PKC_minus_phosph_minus_neurogranin_cplx
type: KineticLaw

569694
kinetic law: 293201
product: 293189
reactant: 293177
reactant: 293165
fast: false
reversible: true
type: Reaction

052143
units: 284709
value: 7.2E-16
type: LocalParameter

296962
stoichiometry: 1.0
species: 563175
type: SpeciesReference

052039
units: 284793
value: 2.2062942E-16
type: LocalParameter

052366
units: 284709
value: 5.4E-16
type: LocalParameter

052091
units: 284793
value: 3.420036E-18
type: LocalParameter

298333
local parameters: 052565
local parameters: 052562
notes: k1*AC_slash_cAMP*AC_slash_CaM_dot_PDE1-k2*AC_slash_CaM_dot_PDE1_slash_CaM_dot_PDE1_slash_CaM_dot_PDE1_cplx
type: KineticLaw

300753
local parameters: 052729
local parameters: 052726
notes: k1*AMPAR_memb_slash_A_B831_star_845_star_*PP1_PSD_slash_PP1_minus_active_PSD-k2*PP1_PSD_slash_PP1_minus_active_PSD_slash_PP1_sbo_20_sbc__slash_PP1_sbo_20_sbc__cplx
type: KineticLaw

052756
units: 284709
value: 3.5E-18
type: LocalParameter

287467
stoichiometry: 1.0
species: 560335
type: SpeciesReference

564115
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 560175
type: Species

292463
stoichiometry: 1.0
species: 561675
type: SpeciesReference

292884
stoichiometry: 1.0
species: 561675
type: SpeciesReference

290363
stoichiometry: 1.0
species: 561455
type: SpeciesReference

288731
stoichiometry: 1.0
species: 560775
type: SpeciesReference

287018
local parameters: 051834
local parameters: 051832
notes: kf*AMPAR_slash_A831_star_845_star__B845_star_-kb*AMPAR_slash_AMPAR_deg
type: KineticLaw

052162
units: 284709
value: 7.2E-16
type: LocalParameter

570894
kinetic law: 296105
product: 296093
reactant: 296081
reactant: 296069
fast: false
reversible: true
type: Reaction

567795
kinetic law: 288212
product: 288200
product: 288188
reactant: 288176
fast: false
reversible: false
type: Reaction

561435
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.00127907407407407
initial amount: NaN
in compartment: 560155
type: Species

565335
constant: true
boundary condition: true
has only substance units: false
initial concentration: 2.0
initial amount: NaN
in compartment: 560175
type: Species

296877
local parameters: 052470
local parameters: 052467
notes: k1*AMPAR_memb_slash_A831_star_845_star__B*PKA_slash_PKA_minus_active-k2*PKA_slash_PKA_minus_active_slash_PKA_sbo_5_sbc__slash_PKA_sbo_5_sbc__cplx
type: KineticLaw

301575
local parameters: 052788
notes: k3*PP1_PSD_slash_PP1_minus_active_PSD_slash_PP1_sbo_28_sbc__slash_PP1_sbo_28_sbc__cplx
type: KineticLaw

290448
stoichiometry: 1.0
species: 560295
type: SpeciesReference

290896
stoichiometry: 1.0
species: 561055
type: SpeciesReference

290944
stoichiometry: 1.0
species: 561675
type: SpeciesReference

564835
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 560155
type: Species

299860
stoichiometry: 1.0
species: 563755
type: SpeciesReference

563815
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 560175
type: Species

562135
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 560155
type: Species

285438
stoichiometry: 1.0
species: 561055
type: SpeciesReference

052427
units: 284709
value: 5.4E-16
type: LocalParameter

293201
local parameters: 052228
local parameters: 052225
notes: k1*AMPAR_memb_slash_A845_star__B*PP2B_slash_CaM_Ca_n_minus_CaNAB-k2*PP2B_slash_CaM_Ca_n_minus_CaNAB_slash_PP2B_sbo_3_sbc__slash_PP2B_sbo_3_sbc__cplx
type: KineticLaw

285229
local parameters: 051717
local parameters: 051715
notes: kf*CaMKII_slash_CaMKII_minus_CaM_minus_PSD-kb*CaM_slash_CaM_minus_Ca4_minus_PSD*CaMKII_slash_CaMKII_minus_PSD
type: KineticLaw

298296
stoichiometry: 1.0
species: 563635
type: SpeciesReference

294390
stoichiometry: 1.0
species: 565015
type: SpeciesReference

285914
stoichiometry: 1.0
species: 561275
type: SpeciesReference

293760
stoichiometry: 1.0
species: 561675
type: SpeciesReference

052716
units: 284709
value: 1.7E-18
type: LocalParameter

302102
stoichiometry: 1.0
species: 564555
type: SpeciesReference

292996
stoichiometry: 1.0
species: 562155
type: SpeciesReference

295864
local parameters: 052403
notes: k3*PKA_slash_PKA_minus_active_slash_PKA_sbo_26_sbc__slash_PKA_sbo_26_sbc__cplx
type: KineticLaw

051849
units: 284709
value: 8.0E-20
type: LocalParameter

568155
kinetic law: 289082
product: 289070
product: 289058
reactant: 289046
fast: false
reversible: false
type: Reaction

567935
kinetic law: 288550
product: 288538
reactant: 288526
reactant: 288514
fast: false
reversible: true
type: Reaction

052477
units: 284709
value: 2.16E-15
type: LocalParameter

570794
kinetic law: 295864
product: 295851
product: 295839
reactant: 295827
fast: false
reversible: false
type: Reaction

295936
stoichiometry: 1.0
species: 564815
type: SpeciesReference

570074
kinetic law: 294123
product: 294110
product: 294098
reactant: 294086
fast: false
reversible: false
type: Reaction

297549
stoichiometry: 1.0
species: 563295
type: SpeciesReference

052800
units: 284793
value: 8.7498E-18
type: LocalParameter

561935
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 560155
type: Species

052426
units: 284709
value: 2.16E-15
type: LocalParameter

285168
stoichiometry: 1.0
species: 560615
type: SpeciesReference

289772
stoichiometry: 1.0
species: 561295
type: SpeciesReference

294245
stoichiometry: 1.0
species: 561675
type: SpeciesReference

294294
stoichiometry: 1.0
species: 565015
type: SpeciesReference

297730
stoichiometry: 1.0
species: 562655
type: SpeciesReference

285634
stoichiometry: 1.0
species: 563655
type: SpeciesReference

572254
kinetic law: 299495
product: 299483
reactant: 299471
reactant: 299459
fast: false
reversible: true
type: Reaction

285083
stoichiometry: 1.0
species: 560535
type: SpeciesReference

291862
stoichiometry: 1.0
species: 564675
type: SpeciesReference

570537
kinetic law: 295234
product: 295222
reactant: 295210
reactant: 295198
fast: false
reversible: true
type: Reaction

052719
units: 284793
value: 8.7498E-18
type: LocalParameter

570714
kinetic law: 295670
product: 295658
product: 295646
reactant: 295634
fast: false
reversible: false
type: Reaction

565695
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 560155
type: Species

052478
units: 284709
value: 5.4E-16
type: LocalParameter

564035
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 560175
type: Species

298272
stoichiometry: 1.0
species: 563535
type: SpeciesReference

287777
local parameters: 051883
local parameters: 051881
notes: k1*CaMKII_slash_CaMKII_minus_CaM*CaMKII_slash_tot_autonomous_CaMKII-k2*CaMKII_slash_tot_autonomous_CaMKII_slash_auton_286_slash_auton_286_cplx
type: KineticLaw

052365
units: 284709
value: 2.16E-15
type: LocalParameter

573354
kinetic law: 302174
product: 302162
product: 302150
product: 302138
reactant: 302126
fast: false
reversible: false
type: Reaction

051920
units: 284709
value: 5.0E-18
type: LocalParameter

286048
stoichiometry: 1.0
species: 561615
type: SpeciesReference

286572
stoichiometry: 1.0
species: 563575
type: SpeciesReference

288356
local parameters: 051914
local parameters: 051911
notes: k1*AMPAR_memb_slash_A_B*CaMKII_slash_actCaMKII_minus_PSD-k2*CaMKII_slash_actCaMKII_minus_PSD_slash_CaMKII_sbo_3_sbc__slash_CaMKII_sbo_3_sbc__cplx
type: KineticLaw

565655
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 560155
type: Species

052759
units: 284793
value: 8.7498E-18
type: LocalParameter

052163
units: 284709
value: 1.8E-16
type: LocalParameter

289977
stoichiometry: 1.0
species: 561355
type: SpeciesReference

284973
stoichiometry: 1.0
species: 560415
type: SpeciesReference

561975
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 560155
type: Species

301731
stoichiometry: 1.0
species: 564455
type: SpeciesReference

052797
units: 284709
value: 3.5E-18
type: LocalParameter

052000
units: 284709
value: 7.50006E-16
type: LocalParameter

296297
local parameters: 052432
local parameters: 052429
notes: k1*AMPAR_slash_A831_star_845_star__B831_star_*PKA_slash_PKA_minus_active-k2*PKA_slash_PKA_minus_active_slash_PKA_sbo_31_sbc__slash_PKA_sbo_31_sbc__cplx
type: KineticLaw

295283
local parameters: 052366
notes: k3*PKA_slash_PKA_minus_active_slash_PKA_sbo_20_sbc__slash_PKA_sbo_20_sbc__cplx
type: KineticLaw

052680
units: 284793
value: 8.7498E-18
type: LocalParameter

300040
stoichiometry: 1.0
species: 565235
type: SpeciesReference

292947
stoichiometry: 1.0
species: 561675
type: SpeciesReference

052055
units: 284793
value: 2.2062942E-16
type: LocalParameter

562955
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 560155
type: Species

052752
units: 284709
value: 3.5E-18
type: LocalParameter

567715
kinetic law: 288020
product: 288008
product: 287996
reactant: 287983
fast: false
reversible: false
type: Reaction

568995
kinetic law: 291115
product: 291103
product: 291091
reactant: 291078
fast: false
reversible: false
type: Reaction

052095
units: 284709
value: 3.06E-17
type: LocalParameter

571534
kinetic law: 297755
product: 297743
reactant: 297730
reactant: 297718
fast: false
reversible: true
type: Reaction

571014
kinetic law: 296442
product: 296430
product: 296418
reactant: 296406
fast: false
reversible: false
type: Reaction

051756
units: 284709
value: 5.4E-15
type: LocalParameter

569434
kinetic law: 292523
product: 292511
reactant: 292499
reactant: 292487
fast: false
reversible: true
type: Reaction

570934
kinetic law: 296201
product: 296189
reactant: 296177
reactant: 296165
fast: false
reversible: true
type: Reaction

286644
stoichiometry: 1.0
species: 563675
type: SpeciesReference

300633
stoichiometry: 1.0
species: 563755
type: SpeciesReference

571094
kinetic law: 296682
product: 296670
reactant: 296658
reactant: 296646
fast: false
reversible: true
type: Reaction

295598
stoichiometry: 1.0
species: 562655
type: SpeciesReference

286717
local parameters: 051813
local parameters: 051811
notes: kf*PP1_PSD_slash_I1_star_*PP1_PSD_slash_PP1_minus_active_PSD-kb*PP1_PSD_slash_PP1_minus_I1_star_
type: KineticLaw

052600
units: 284793
value: 8.7498E-18
type: LocalParameter

300148
stoichiometry: 1.0
species: 563755
type: SpeciesReference

295488
stoichiometry: 1.0
species: 564915
type: SpeciesReference

052794
units: 284709
value: 1.4E-17
type: LocalParameter

288393
stoichiometry: 1.0
species: 565595
type: SpeciesReference

561355
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.111111111111111
initial amount: NaN
in compartment: 560155
type: Species

571054
kinetic law: 296586
product: 296574
reactant: 296562
reactant: 296550
fast: false
reversible: true
type: Reaction

301539
stoichiometry: 1.0
species: 564415
type: SpeciesReference

290327
stoichiometry: 1.0
species: 561455
type: SpeciesReference

293652
stoichiometry: 1.0
species: 565235
type: SpeciesReference

296768
stoichiometry: 1.0
species: 563135
type: SpeciesReference

569015
kinetic law: 291163
product: 291151
reactant: 291139
reactant: 291127
fast: false
reversible: true
type: Reaction

292349
stoichiometry: 1.0
species: 564835
type: SpeciesReference

567315
kinetic law: 287102
product: 287090
reactant: 287078
reactant: 287066
fast: false
reversible: true
type: Reaction

052753
units: 284793
value: 8.7498E-18
type: LocalParameter

285340
stoichiometry: 1.0
species: 560995
type: SpeciesReference

291030
stoichiometry: 1.0
species: 561315
type: SpeciesReference

052094
units: 284709
value: 1.224E-16
type: LocalParameter

285743
local parameters: 051750
local parameters: 051748
notes: kf*CaM_slash_neurogranin_star__PSD-kb*CaM_slash_neurogranin_PSD
type: KineticLaw

051757
units: 284793
value: 4.4998254E-14
type: LocalParameter

564195
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 560175
type: Species

286789
stoichiometry: 1.0
species: 564875
type: SpeciesReference

052362
units: 284793
value: 3.5998992E-16
type: LocalParameter

052712
units: 284793
value: 8.7498E-18
type: LocalParameter

293359
stoichiometry: 1.0
species: 565215
type: SpeciesReference

568955
kinetic law: 291018
product: 291005
product: 290993
reactant: 290980
fast: false
reversible: false
type: Reaction

289022
stoichiometry: 1.0
species: 560835
type: SpeciesReference

301683
stoichiometry: 1.0
species: 565075
type: SpeciesReference

298019
stoichiometry: 1.0
species: 563455
type: SpeciesReference

289106
stoichiometry: 1.0
species: 565595
type: SpeciesReference

298480
local parameters: 052572
notes: k3*PP1_PSD_slash_PP1_minus_active_PSD_slash_Deph_minus_thr286_slash_Deph_minus_thr286_cplx
type: KineticLaw

566375
kinetic law: 284949
product: 284937
reactant: 284925
reactant: 284913
notes: Affinity is up 1000X. Time to release is about 20 sec, so the kb is OK at 0.1 This makes Kf around 1.6666e-3
fast: false
reversible: true
type: Reaction

287910
stoichiometry: 1.0
species: 565555
type: SpeciesReference

052791
units: 284793
value: 8.7498E-18
type: LocalParameter

299968
stoichiometry: 1.0
species: 564095
type: SpeciesReference

569954
kinetic law: 293832
product: 293820
product: 293808
reactant: 293796
fast: false
reversible: false
type: Reaction

291103
stoichiometry: 1.0
species: 561675
type: SpeciesReference

292571
local parameters: 052183
notes: k3*PP2B_slash_CaM_Ca_n_minus_CaNAB_slash_PP2B_sbo_29_sbc__slash_PP2B_sbo_29_sbc__cplx
type: KineticLaw

565615
constant: false
boundary condition: true
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 560175
type: Species

052003
units: 284709
value: 1.8E-16
type: LocalParameter

564795
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 560155
type: Species

292388
stoichiometry: 1.0
species: 564815
type: SpeciesReference

289508
stoichiometry: 1.0
species: 560935
type: SpeciesReference

293541
local parameters: 052247
notes: k3*PP2B_slash_CaM_Ca_n_minus_CaNAB_slash_PP2B_sbo_6_sbc__slash_PP2B_sbo_6_sbc__cplx
type: KineticLaw

052715
units: 284709
value: 6.8E-18
type: LocalParameter

290049
local parameters: 052015
notes: k3*PP1_slash_PP2A_slash_PP2A_minus_dephosph_minus_I1_PSD_slash_PP2A_minus_dephosph_minus_I1_PSD_cplx
type: KineticLaw

298855
stoichiometry: 1.0
species: 563755
type: SpeciesReference

287886
stoichiometry: 1.0
species: 560575
type: SpeciesReference

051959
units: 284793
value: 2.77776E-19
type: LocalParameter

299035
stoichiometry: 1.0
species: 564975
type: SpeciesReference

052052
units: 284709
value: 2.25E-16
type: LocalParameter

286681
stoichiometry: 1.0
species: 563695
type: SpeciesReference

293614
stoichiometry: 1.0
species: 564995
type: SpeciesReference

052803
units: 284709
value: 1.4E-17
type: LocalParameter

571614
kinetic law: 297947
modifier: 297935
product: 297923
reactant: 297911
notes: 17 Feb 2005 Halved Vmax as the amount of enzyme has been doubled to get an integer value in the spine. 18 Feb 2005. Updated Km from BRENDA: EC No 4.6.1.1 Rat Km: 0.95 mM Turnover 12/sec. Human Km: 0.3 mM 12 umol/min/mg for mammalia, turnover is 12/sec See PMID 8663304 by Dessauer and Gilman JBC 271 1996 Unfortunately turnover range is from 34 down to 0.1 in different studies, according to BRENDA.
fast: false
reversible: false
type: Reaction

564695
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 560155
type: Species

290908
stoichiometry: 1.0
species: 561675
type: SpeciesReference

052429
units: 284793
value: 3.5998992E-16
type: LocalParameter

052755
units: 284709
value: 1.4E-17
type: LocalParameter

299823
stoichiometry: 1.0
species: 563755
type: SpeciesReference

572634
kinetic law: 300415
product: 300403
product: 300391
reactant: 300379
fast: false
reversible: false
type: Reaction

051759
units: 284709
value: 9.0E-18
type: LocalParameter

052360
units: 284709
value: 5.4E-16
type: LocalParameter

569614
kinetic law: 293008
product: 292996
reactant: 292984
reactant: 292971
fast: false
reversible: true
type: Reaction

287273
stoichiometry: 1.0
species: 564655
type: SpeciesReference

296574
stoichiometry: 1.0
species: 563095
type: SpeciesReference

288622
stoichiometry: 1.0
species: 565595
type: SpeciesReference

297610
local parameters: 052517
notes: k3*PKA_slash_PKA_minus_active_slash_PKA_sbo_12_sbc__slash_PKA_sbo_12_sbc__cplx
type: KineticLaw

300354
stoichiometry: 1.0
species: 564175
type: SpeciesReference

567695
kinetic law: 287971
product: 287959
reactant: 287947
reactant: 287934
fast: false
reversible: true
type: Reaction

288200
stoichiometry: 1.0
species: 565595
type: SpeciesReference

295379
local parameters: 052372
notes: k3*PKA_slash_PKA_minus_active_slash_PKA_sbo_21_sbc__slash_PKA_sbo_21_sbc__cplx
type: KineticLaw

286366
local parameters: 051789
local parameters: 051787
notes: kf*PKA_slash_R2C_minus_cAMP4-kb*PKA_slash_PKA_minus_active*PKA_slash_R2_minus_cAMP4
type: KineticLaw

051804
units: 284709
value: 4.5E-16
type: LocalParameter

290400
stoichiometry: 1.0
species: 561515
type: SpeciesReference

287959
stoichiometry: 1.0
species: 560595
type: SpeciesReference

572154
kinetic law: 299255
product: 299243
product: 299230
reactant: 299218
fast: false
reversible: false
type: Reaction

293249
local parameters: 052229
notes: k3*PP2B_slash_CaM_Ca_n_minus_CaNAB_slash_PP2B_sbo_3_sbc__slash_PP2B_sbo_3_sbc__cplx
type: KineticLaw

302438
stoichiometry: 1.0
species: 561075
type: SpeciesReference

288284
stoichiometry: 1.0
species: 565055
type: SpeciesReference

293832
local parameters: 052265
notes: k3*PP2B_slash_CaM_Ca_n_minus_CaNAB_slash_PP2B_sbo_9_sbc__slash_PP2B_sbo_9_sbc__cplx
type: KineticLaw

300524
stoichiometry: 1.0
species: 565195
type: SpeciesReference

052470
units: 284709
value: 2.16E-15
type: LocalParameter

052604
units: 284709
value: 1.7E-18
type: LocalParameter

288550
local parameters: 051924
local parameters: 051922
notes: k1*AMPAR_memb_slash_A_B845_star_*CaMKII_slash_actCaMKII_minus_PSD-k2*CaMKII_slash_actCaMKII_minus_PSD_slash_CaMKII_sbo_5_sbc__slash_CaMKII_sbo_5_sbc__cplx
type: KineticLaw

298662
stoichiometry: 1.0
species: 563755
type: SpeciesReference

052643
units: 284709
value: 6.8E-18
type: LocalParameter

299375
stoichiometry: 1.0
species: 563755
type: SpeciesReference

567535
kinetic law: 287583
product: 287569
reactant: 287556
reactant: 287543
fast: false
reversible: true
type: Reaction

567375
kinetic law: 287248
product: 287236
reactant: 287224
reactant: 287212
notes: Exo rates are scaled from earlier model versions to account for binding of anchor. We have about 200 molecules of anchor in the whole model. Here we select rates to give us a max of about 150 molecules of GluR at the synapse.
fast: false
reversible: true
type: Reaction

288938
local parameters: 051945
local parameters: 051943
notes: k1*AMPAR_memb_slash_A_B831_star_845_star_*CaMKII_slash_actCaMKII_minus_PSD-k2*CaMKII_slash_actCaMKII_minus_PSD_slash_CaMKII_sbo_9_sbc__slash_CaMKII_sbo_9_sbc__cplx
type: KineticLaw

297022
local parameters: 052478
notes: k3*PKA_slash_PKA_minus_active_slash_PKA_sbo_6_sbc__slash_PKA_sbo_6_sbc__cplx
type: KineticLaw

562515
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 560155
type: Species

052686
units: 284793
value: 8.7498E-18
type: LocalParameter

572434
kinetic law: 299932
product: 299920
product: 299908
reactant: 299896
fast: false
reversible: false
type: Reaction

051753
units: 284709
value: 9.0E-16
type: LocalParameter

052006
units: 284793
value: 5.81256E-17
type: LocalParameter

052471
units: 284709
value: 5.4E-16
type: LocalParameter

570114
kinetic law: 294221
product: 294209
product: 294196
reactant: 294184
fast: false
reversible: false
type: Reaction

285498
stoichiometry: 1.0
species: 561055
type: SpeciesReference

294184
stoichiometry: 1.0
species: 562395
type: SpeciesReference

052603
units: 284709
value: 6.8E-18
type: LocalParameter

052644
units: 284709
value: 1.7E-18
type: LocalParameter

286315
local parameters: 051786
local parameters: 051784
notes: kf*PKA_slash_R2C2_minus_cAMP4-kb*PKA_slash_PKA_minus_active*PKA_slash_R2C_minus_cAMP4
type: KineticLaw

286291
stoichiometry: 1.0
species: 562655
type: SpeciesReference

301284
local parameters: 052763
notes: k3*PP1_PSD_slash_PP1_minus_active_PSD_slash_PP1_sbo_25_sbc__slash_PP1_sbo_25_sbc__cplx
type: KineticLaw

292128
local parameters: 052156
local parameters: 052153
notes: k1*AMPAR_slash_A845_star__B845_star_*PP2B_slash_CaM_Ca_n_minus_CaNAB-k2*PP2B_slash_CaM_Ca_n_minus_CaNAB_slash_PP2B_sbo_25_sbc__slash_PP2B_sbo_25_sbc__cplx
type: KineticLaw

291187
stoichiometry: 1.0
species: 563675
type: SpeciesReference

294778
stoichiometry: 1.0
species: 563695
type: SpeciesReference

294814
stoichiometry: 1.0
species: 564655
type: SpeciesReference

296141
stoichiometry: 1.0
species: 562655
type: SpeciesReference

292273
local parameters: 052163
notes: k3*PP2B_slash_CaM_Ca_n_minus_CaNAB_slash_PP2B_sbo_26_sbc__slash_PP2B_sbo_26_sbc__cplx
type: KineticLaw

051712
units: 284709
value: 1.0E-17
type: LocalParameter

560875
constant: false
boundary condition: false
has only substance units: false
initial concentration: 4.06666666666667E-215
initial amount: NaN
in compartment: 560175
type: Species

300560
local parameters: 052715
local parameters: 052712
notes: k1*AMPAR_memb_slash_A831_star__B831_star_845_star_*PP1_PSD_slash_PP1_minus_active_PSD-k2*PP1_PSD_slash_PP1_minus_active_PSD_slash_PP1_sbo_18_sbc__slash_PP1_sbo_18_sbc__cplx
type: KineticLaw

052683
units: 284709
value: 6.8E-18
type: LocalParameter

051754
units: 284709
value: 5.4E-15
type: LocalParameter

288514
stoichiometry: 1.0
species: 565095
type: SpeciesReference

299483
stoichiometry: 1.0
species: 563995
type: SpeciesReference

298746
stoichiometry: 1.0
species: 560435
type: SpeciesReference

294026
local parameters: 052278
notes: k3*PP2B_slash_CaM_Ca_n_minus_CaNAB_slash_PP2B_sbo_11_sbc__slash_PP2B_sbo_11_sbc__cplx
type: KineticLaw

285791
local parameters: 051753
local parameters: 051751
notes: kf*CaM_slash_CaM_minus_Ca3*Ca-kb*CaM_slash_CaM_minus_Ca4
type: KineticLaw

569155
kinetic law: 291597
product: 291585
product: 291573
reactant: 291560
fast: false
reversible: false
type: Reaction

562595
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 560155
type: Species

299543
local parameters: 052644
notes: k3*PP1_PSD_slash_PP1_minus_active_PSD_slash_PP1_sbo_7_sbc__slash_PP1_sbo_7_sbc__cplx
type: KineticLaw

561295
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 560155
type: Species

051802
units: 284793
value: 6.479838E-14
type: LocalParameter

285851
stoichiometry: 1.0
species: 561455
type: SpeciesReference

290158
stoichiometry: 1.0
species: 560275
type: SpeciesReference

563275
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 560155
type: Species

287090
stoichiometry: 1.0
species: 565255
type: SpeciesReference

291332
stoichiometry: 1.0
species: 561675
type: SpeciesReference

301357
stoichiometry: 1.0
species: 565115
type: SpeciesReference

560275
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 560155
type: Species

291935
local parameters: 052143
local parameters: 052140
notes: k1*AMPAR_slash_A_B831_star_845_star_*PP2B_slash_CaM_Ca_n_minus_CaNAB-k2*PP2B_slash_CaM_Ca_n_minus_CaNAB_slash_PP2B_sbo_23_sbc__slash_PP2B_sbo_23_sbc__cplx
type: KineticLaw

301092
local parameters: 052752
notes: k3*PP1_PSD_slash_PP1_minus_active_PSD_slash_PP1_sbo_23_sbc__slash_PP1_sbo_23_sbc__cplx
type: KineticLaw

570474
kinetic law: 295090
product: 295078
product: 295066
reactant: 295054
fast: false
reversible: false
type: Reaction

052097
units: 284793
value: 3.420036E-18
type: LocalParameter

051715
units: 284709
value: 5.0E-17
type: LocalParameter

295706
stoichiometry: 1.0
species: 562915
type: SpeciesReference

052302
units: 284793
value: 2.011824E-17
type: LocalParameter

289325
local parameters: 051966
local parameters: 051964
notes: k1*AMPAR_memb_slash_A831_star__B845_star_*CaMKII_slash_actCaMKII_minus_PSD-k2*CaMKII_slash_actCaMKII_minus_PSD_slash_CaMKII_sbo_13_sbc__slash_CaMKII_sbo_13_sbc__cplx
type: KineticLaw

302258
stoichiometry: 1.0
species: 564515
type: SpeciesReference

299604
stoichiometry: 1.0
species: 564015
type: SpeciesReference

052684
units: 284709
value: 1.7E-18
type: LocalParameter

564615
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 560155
type: Species

297501
stoichiometry: 1.0
species: 562655
type: SpeciesReference

052008
units: 284709
value: 7.50006E-16
type: LocalParameter

290255
stoichiometry: 1.0
species: 560315
type: SpeciesReference

300463
local parameters: 052709
local parameters: 052706
notes: k1*AMPAR_memb_slash_A835_star_845_star__B835_star_845_star_*PP1_PSD_slash_PP1_minus_active_PSD-k2*PP1_PSD_slash_PP1_minus_active_PSD_slash_PP1_sbo_17_sbc__slash_PP1_sbo_17_sbc__cplx
type: KineticLaw

051801
units: 284709
value: 0.0
type: LocalParameter

286427
stoichiometry: 1.0
species: 561255
type: SpeciesReference

052710
units: 284709
value: 1.7E-18
type: LocalParameter

289253
stoichiometry: 1.0
species: 565255
type: SpeciesReference

299471
stoichiometry: 1.0
species: 563755
type: SpeciesReference

569154
kinetic law: 291548
product: 291536
reactant: 291524
reactant: 291512
fast: false
reversible: true
type: Reaction

301779
stoichiometry: 1.0
species: 565015
type: SpeciesReference

572474
kinetic law: 300028
product: 300016
product: 300004
reactant: 299992
fast: false
reversible: false
type: Reaction

287382
stoichiometry: 1.0
species: 560215
type: SpeciesReference

296682
local parameters: 052456
local parameters: 052453
notes: k1*AMPAR_memb_slash_A_B*PKA_slash_PKA_minus_active-k2*PKA_slash_PKA_minus_active_slash_PKA_sbo_3_sbc__slash_PKA_sbo_3_sbc__cplx
type: KineticLaw

569195
kinetic law: 291693
product: 291681
product: 291669
reactant: 291657
fast: false
reversible: false
type: Reaction

296828
local parameters: 052464
notes: k3*PKA_slash_PKA_minus_active_slash_PKA_sbo_4_sbc__slash_PKA_sbo_4_sbc__cplx
type: KineticLaw

563335
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 560155
type: Species

285388
stoichiometry: 1.0
species: 561155
type: SpeciesReference

052646
units: 284793
value: 8.7498E-18
type: LocalParameter

563235
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 560155
type: Species

566595
kinetic law: 285474
product: 285462
reactant: 285450
reactant: 285438
notes: Surprisingly, no direct info on rates from neurogranin at this time. These rates are based on GAP-43 binding studies. As GAP-43 and neurogranin share near identity in the CaM/PKC binding regions, and also similarity in phosph and dephosph rates, I am borrowing GAP-43 kinetic info. See Alexander et al JBC 262:13 6108-6113 1987
fast: false
reversible: true
type: Reaction

051714
units: 284709
value: 1.0E-17
type: LocalParameter

292739
stoichiometry: 1.0
species: 564895
type: SpeciesReference

566795
kinetic law: 285926
product: 285914
product: 285902
reactant: 285889
notes: Let us assume that the equil in this case is very far over to the right. This is probably safe.
fast: false
reversible: true
type: Reaction

294850
local parameters: 052340
local parameters: 052337
notes: k1*AMPAR_slash_A_B*PKA_slash_PKA_minus_active-k2*PKA_slash_PKA_minus_active_slash_PKA_sbo_17_sbc__slash_PKA_sbo_17_sbc__cplx
type: KineticLaw

285523
stoichiometry: 1.0
species: 561075
type: SpeciesReference

570314
kinetic law: 294706
product: 294694
product: 294682
reactant: 294670
fast: false
reversible: false
type: Reaction

052689
units: 284709
value: 6.8E-18
type: LocalParameter

291078
stoichiometry: 1.0
species: 561735
type: SpeciesReference

287358
local parameters: 051858
local parameters: 051856
notes: kf*PKC_minus_control-kb*PKC_minus_active
type: KineticLaw

052009
units: 284709
value: 1.8E-16
type: LocalParameter

299267
stoichiometry: 1.0
species: 565215
type: SpeciesReference

292019
stoichiometry: 1.0
species: 561935
type: SpeciesReference

052271
units: 284709
value: 1.8E-16
type: LocalParameter

287127
stoichiometry: 1.0
species: 565295
type: SpeciesReference

052537
units: 284709
value: 4.05E-16
type: LocalParameter

051808
units: 284709
value: 1.0E-17
type: LocalParameter

051780
units: 284709
value: 9.9E-15
type: LocalParameter

568095
kinetic law: 288938
product: 288925
reactant: 288913
reactant: 288901
fast: false
reversible: true
type: Reaction

293080
stoichiometry: 1.0
species: 561675
type: SpeciesReference

568415
kinetic law: 289712
product: 289700
reactant: 289688
reactant: 289676
fast: false
reversible: true
type: Reaction

290556
stoichiometry: 1.0
species: 561455
type: SpeciesReference

052607
units: 284793
value: 8.7498E-18
type: LocalParameter

566435
kinetic law: 285096
product: 285083
reactant: 285071
reactant: 285059
notes: Rates to match curve in fig2 from Shen and Meyer, Science 284:162-166(1999), calculated for 6:1 alpha:beta CaMKII heterodimers
fast: false
reversible: true
type: Reaction

295973
stoichiometry: 1.0
species: 564695
type: SpeciesReference

294135
stoichiometry: 1.0
species: 565255
type: SpeciesReference

297959
stoichiometry: 1.0
species: 565355
type: SpeciesReference

052270
units: 284709
value: 7.2E-16
type: LocalParameter

300088
stoichiometry: 1.0
species: 564115
type: SpeciesReference

293032
stoichiometry: 1.0
species: 565035
type: SpeciesReference

051807
units: 284709
value: 2.7E-14
type: LocalParameter

300861
stoichiometry: 1.0
species: 564275
type: SpeciesReference

289929
stoichiometry: 1.0
species: 561335
type: SpeciesReference

284769
exponent: -2.0
scale: -6
multipler: 1.0
kind: MOLE
type: SBMLUnit

293310
stoichiometry: 1.0
species: 562215
type: SpeciesReference

288840
local parameters: 051939
local parameters: 051937
notes: k1*AMPAR_memb_slash_A845_star__B831_star_845_star_*CaMKII_slash_actCaMKII_minus_PSD-k2*CaMKII_slash_actCaMKII_minus_PSD_slash_CaMKII_sbo_8_sbc__slash_CaMKII_sbo_8_sbc__cplx
type: KineticLaw

298553
stoichiometry: 1.0
species: 560475
type: SpeciesReference

560675
constant: false
boundary condition: false
has only substance units: false
initial concentration: 3.588E-215
initial amount: NaN
in compartment: 560175
type: Species

051781
units: 284793
value: 6.750054E-15
type: LocalParameter

MODEL9086518048
species: 562175
reaction: 567635
species: 564975
rule: 566175
species: 565635
species: 562955
species: 560815
reaction: 572054
length unit: length
reaction: 569614
reaction: 572774
reaction: 570014
reaction: 569255
species: 562275
species: 562015
species: 561715
reaction: 570614
species: 561695
species: 562695
species: 562435
species: 561435
reaction: 571894
species: 562035
species: 561035
reaction: 572414
reaction: 571274
species: 565055
reaction: 571694
reaction: 571074
reaction: 571234
reaction: 568115
reaction: 570134
reaction: 571654
species: 565475
reaction: 566915
species: 563695
species: 564435
species: 564695
reaction: 568775
reaction: 569115
species: 563435
reaction: 570914
species: 563855
reaction: 570554
reaction: 568175
reaction: 566395
reaction: 571774
reaction: 568595
reaction: 566655
species: 560515
reaction: 572654
reaction: 570934
rule: 565935
rule: 565975
species: 562615
reaction: 572954
reaction: 572134
species: 561155
species: 563955
species: 561615
species: 565175
species: 563755
reaction: 569355
reaction: 571794
species: 565595
reaction: 572714
species: 564995
species: 564175
species: 563555
species: 560795
rule: 566275
species: 564615
reaction: 568055
species: 563615
rule: 565995
reaction: 567615
species: 560395
species: 564595
rule: 566015
rule: 566055

563555
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 560155
type: Species

293941
stoichiometry: 1.0
species: 565115
type: SpeciesReference

302210
stoichiometry: 1.0
species: 564575
type: SpeciesReference

569215
kinetic law: 291741
product: 291729
reactant: 291717
reactant: 291705
fast: false
reversible: true
type: Reaction

292523
local parameters: 052182
local parameters: 052179
notes: k1*AMPAR_slash_A845_star__B845_star_*PP2B_slash_CaM_Ca_n_minus_CaNAB-k2*PP2B_slash_CaM_Ca_n_minus_CaNAB_slash_PP2B_sbo_29_sbc__slash_PP2B_sbo_29_sbc__cplx
type: KineticLaw

291971
stoichiometry: 1.0
species: 561675
type: SpeciesReference

298625
local parameters: 052584
local parameters: 052581
notes: k1*CaMKII_slash_CaMKII_star__star__star__minus_PSD*PP1_PSD_slash_PP1_minus_active_PSD-k2*PP1_PSD_slash_PP1_minus_active_PSD_slash_Deph_minus_thr305_slash_Deph_minus_thr305_cplx
type: KineticLaw

295018
stoichiometry: 1.0
species: 562655
type: SpeciesReference

296937
stoichiometry: 1.0
species: 564995
type: SpeciesReference

284865
stoichiometry: 1.0
species: 561255
type: SpeciesReference

051750
units: 284709
value: 0.0
type: LocalParameter

293396
local parameters: 052240
local parameters: 052237
notes: k1*AMPAR_memb_slash_A831_star_845_star__B845_star_*PP2B_slash_CaM_Ca_n_minus_CaNAB-k2*PP2B_slash_CaM_Ca_n_minus_CaNAB_slash_PP2B_sbo_5_sbc__slash_PP2B_sbo_5_sbc__cplx
type: KineticLaw

302198
stoichiometry: 1.0
species: 564515
type: SpeciesReference

052649
units: 284709
value: 1.4E-17
type: LocalParameter

292836
stoichiometry: 1.0
species: 564935
type: SpeciesReference

051711
units: 284709
value: 0.0
type: LocalParameter

052535
units: 284709
value: 5.4E-16
type: LocalParameter

295827
stoichiometry: 1.0
species: 562935
type: SpeciesReference

052368
units: 284793
value: 3.5998992E-16
type: LocalParameter

289362
stoichiometry: 1.0
species: 565595
type: SpeciesReference

295078
stoichiometry: 1.0
species: 562655
type: SpeciesReference

297658
local parameters: 052522
local parameters: 052519
notes: k1*AMPAR_memb_slash_A831_star_845_star__B831_star_*PKA_slash_PKA_minus_active-k2*PKA_slash_PKA_minus_active_slash_PKA_sbo_13_sbc__slash_PKA_sbo_13_sbc__cplx
type: KineticLaw

288248
stoichiometry: 1.0
species: 560675
type: SpeciesReference

301803
stoichiometry: 1.0
species: 564475
type: SpeciesReference

286982
local parameters: 051831
local parameters: 051829
notes: kf*AMPAR_slash_A845_star__B831_star_845_star_-kb*AMPAR_slash_AMPAR_deg
type: KineticLaw

051805
units: 284709
value: 2.7E-14
type: LocalParameter

566515
kinetic law: 285278
product: 285265
reactant: 285253
reactant: 285241
fast: false
reversible: true
type: Reaction

051751
units: 284793
value: 4.1849946E-17
type: LocalParameter

285803
stoichiometry: 1.0
species: 561195
type: SpeciesReference

301840
stoichiometry: 1.0
species: 564995
type: SpeciesReference

289664
local parameters: 051987
notes: k3*CaMKII_slash_tot_minus_CaM_minus_CaMKII_minus_PSD_slash_CaM_minus_act_minus_305_minus_PSD_slash_CaM_minus_act_minus_305_minus_PSD_cplx
type: KineticLaw

560515
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 560175
type: Species

302294
stoichiometry: 1.0
species: 564515
type: SpeciesReference

291789
local parameters: 052131
notes: k3*PP2B_slash_CaM_Ca_n_minus_CaNAB_slash_PP2B_sbo_21_sbc__slash_PP2B_sbo_21_sbc__cplx
type: KineticLaw

296189
stoichiometry: 1.0
species: 563015
type: SpeciesReference

052534
units: 284709
value: 2.16E-15
type: LocalParameter

560575
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 560175
type: Species

569255
kinetic law: 291886
product: 291874
product: 291862
reactant: 291850
fast: false
reversible: false
type: Reaction

569894
kinetic law: 293688
product: 293676
reactant: 293664
reactant: 293652
fast: false
reversible: true
type: Reaction

568235
kinetic law: 289277
product: 289265
product: 289253
reactant: 289241
fast: false
reversible: false
type: Reaction

051783
units: 284709
value: 2.925E-15
type: LocalParameter

052474
units: 284793
value: 3.999888E-17
type: LocalParameter

052309
units: 284793
value: 3.336012E-18
type: LocalParameter

300196
stoichiometry: 1.0
species: 565000
type: SpeciesReference

293736
local parameters: 052259
notes: k3*PP2B_slash_CaM_Ca_n_minus_CaNAB_slash_PP2B_sbo_8_sbc__slash_PP2B_sbo_8_sbc__cplx
type: KineticLaw

296538
local parameters: 052445
notes: k3*PKA_slash_PKA_minus_active_slash_PKA_sbo_1_sbc__slash_PKA_sbo_1_sbc__cplx
type: KineticLaw

562495
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 560155
type: Species

290508
stoichiometry: 1.0
species: 560415
type: SpeciesReference

287837
stoichiometry: 1.0
species: 560515
type: SpeciesReference

564475
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 560175
type: Species

290739
stoichiometry: 1.0
species: 563695
type: SpeciesReference

302114
local parameters: 052839
local parameters: 052836
notes: k1*CaM_slash_neurogranin_minus_CaM*PKC_minus_active-k2*PKC_minus_active_slash_PKC_minus_phosph_minus_ng_minus_CaM_slash_PKC_minus_phosph_minus_ng_minus_CaM_cplx
type: KineticLaw

571834
kinetic law: 298480
product: 298468
product: 298456
reactant: 298443
fast: false
reversible: false
type: Reaction

298963
local parameters: 052604
notes: k3*PP1_PSD_slash_PP1_minus_active_PSD_slash_PP1_sbo_1_sbc__slash_PP1_sbo_1_sbc__cplx
type: KineticLaw

561475
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 560155
type: Species

051708
units: 284709
value: 0.0
type: LocalParameter

562815
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 560155
type: Species

301128
stoichiometry: 1.0
species: 564335
type: SpeciesReference

297340
stoichiometry: 1.0
species: 562655
type: SpeciesReference

567895
kinetic law: 288454
product: 288442
reactant: 288430
reactant: 288417
fast: false
reversible: true
type: Reaction

288308
local parameters: 051909
notes: k3*CaMKII_slash_actCaMKII_minus_PSD_slash_CaMKII_sbo_2_sbc__slash_CaMKII_sbo_2_sbc__cplx
type: KineticLaw

287200
local parameters: 051846
local parameters: 051844
notes: kf*AMPAR_slash_A831_star_845_star__B845_star_*AMPAR_memb_slash_Anchor-kb*AMPAR_memb_slash_A831_star_845_star__B845_star_
type: KineticLaw

569254
kinetic law: 291837
product: 291825
reactant: 291813
reactant: 291801
fast: false
reversible: true
type: Reaction

051784
units: 284709
value: 5.4E-15
type: LocalParameter

285707
local parameters: 051747
local parameters: 051745
notes: kf*CaM_slash_neurogranin_PSD*CaM_slash_CaM_minus_PSD-kb*CaM_slash_neurogranin_minus_CaM_PSD
type: KineticLaw

570034
kinetic law: 294026
product: 294014
product: 294002
reactant: 293990
fast: false
reversible: false
type: Reaction

052571
units: 284709
value: 1.0E-16
type: LocalParameter

289724
stoichiometry: 1.0
species: 560975
type: SpeciesReference

567855
kinetic law: 288356
product: 288344
reactant: 288332
reactant: 288320
fast: false
reversible: true
type: Reaction

052264
units: 284709
value: 7.2E-16
type: LocalParameter

297995
local parameters: 052543
local parameters: 052541
notes: kcat*AC_slash_AC2_star_*AC_slash_ATP/(Km+AC_slash_ATP)
type: KineticLaw

293432
stoichiometry: 1.0
species: 561675
type: SpeciesReference

052467
units: 284793
value: 3.999888E-17
type: LocalParameter

295234
local parameters: 052365
local parameters: 052362
notes: k1*AMPAR_slash_A_B*PKA_slash_PKA_minus_active-k2*PKA_slash_PKA_minus_active_slash_PKA_sbo_20_sbc__slash_PKA_sbo_20_sbc__cplx
type: KineticLaw

052830
units: 284709
value: 2.106E-16
type: LocalParameter

051709
units: 284793
value: 1.08E-20
type: LocalParameter

052572
units: 284709
value: 2.5E-17
type: LocalParameter

572894
kinetic law: 301044
product: 301032
reactant: 301020
reactant: 301007
fast: false
reversible: true
type: Reaction

287163
stoichiometry: 1.0
species: 564775
type: SpeciesReference

051961
units: 284709
value: 2.0E-17
type: LocalParameter

571874
kinetic law: 298577
product: 298565
product: 298553
reactant: 298540
fast: false
reversible: false
type: Reaction

291416
stoichiometry: 1.0
species: 564715
type: SpeciesReference

293189
stoichiometry: 1.0
species: 562195
type: SpeciesReference

568115
kinetic law: 288986
product: 288974
product: 288962
reactant: 288950
fast: false
reversible: false
type: Reaction

300306
stoichiometry: 1.0
species: 563755
type: SpeciesReference

300825
stoichiometry: 1.0
species: 563755
type: SpeciesReference

290085
stoichiometry: 1.0
species: 561435
type: SpeciesReference

564435
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 560175
type: Species

051787
units: 284709
value: 5.4E-15
type: LocalParameter

572054
kinetic law: 299011
product: 298999
reactant: 298987
reactant: 298975
fast: false
reversible: true
type: Reaction

297803
local parameters: 052529
notes: k3*PKA_slash_PKA_minus_active_slash_PKA_sbo_14_sbc__slash_PKA_sbo_14_sbc__cplx
type: KineticLaw

569914
kinetic law: 293736
product: 293724
product: 293712
reactant: 293700
fast: false
reversible: false
type: Reaction

299327
stoichiometry: 1.0
species: 565055
type: SpeciesReference

572294
kinetic law: 299592
product: 299580
reactant: 299568
reactant: 299556
fast: false
reversible: true
type: Reaction

284829
exponent: -1.0
scale: 0
multipler: 1.0
kind: SECOND
type: SBMLUnit

572914
kinetic law: 301092
product: 301080
product: 301068
reactant: 301056
fast: false
reversible: false
type: Reaction

052265
units: 284709
value: 1.8E-16
type: LocalParameter

571374
kinetic law: 297366
product: 297353
reactant: 297340
reactant: 297327
fast: false
reversible: true
type: Reaction

295186
local parameters: 052360
notes: k3*PKA_slash_PKA_minus_active_slash_PKA_sbo_19_sbc__slash_PKA_sbo_19_sbc__cplx
type: KineticLaw

573314
kinetic law: 302066
product: 302054
product: 302042
reactant: 302030
fast: false
reversible: false
type: Reaction

568735
kinetic law: 290484
product: 290472
reactant: 290460
reactant: 290448
fast: false
reversible: true
type: Reaction

568195
kinetic law: 289181
product: 289168
product: 289156
reactant: 289144
fast: false
reversible: false
type: Reaction

285572
stoichiometry: 1.0
species: 561235
type: SpeciesReference

562775
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 560155
type: Species

052113
units: 284709
value: 1.8E-16
type: LocalParameter

294730
stoichiometry: 1.0
species: 562655
type: SpeciesReference

562175
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 560155
type: Species

568635
kinetic law: 290243
product: 290231
product: 290219
reactant: 290207
fast: false
reversible: false
type: Reaction

052531
units: 284793
value: 3.999888E-17
type: LocalParameter

286826
stoichiometry: 1.0
species: 564995
type: SpeciesReference

295126
stoichiometry: 1.0
species: 562795
type: SpeciesReference

292631
stoichiometry: 1.0
species: 562055
type: SpeciesReference

289483
stoichiometry: 1.0
species: 564995
type: SpeciesReference

295331
local parameters: 052371
local parameters: 052368
notes: k1*AMPAR_slash_A831_star__B*PKA_slash_PKA_minus_active-k2*PKA_slash_PKA_minus_active_slash_PKA_sbo_21_sbc__slash_PKA_sbo_21_sbc__cplx
type: KineticLaw

051786
units: 284793
value: 1.6199838E-15
type: LocalParameter

289760
local parameters: 051995
notes: k3*CaMKII_slash_tot_minus_CaM_minus_CaMKII_minus_PSD_slash_CaM_minus_act_minus_286_minus_PSD_slash_CaM_minus_act_minus_286_minus_PSD_cplx
type: KineticLaw

300257
stoichiometry: 1.0
species: 564155
type: SpeciesReference

571774
kinetic law: 298333
product: 298321
reactant: 298309
reactant: 298296
notes: Max activity ~10umol/min/mg in presence of lots of CaM. Affinity is low, 40 uM. k3 = 10, k2 = 40, k1 = (50/40) / 6e5.
fast: false
reversible: true
type: Reaction

567975
kinetic law: 288646
product: 288634
reactant: 288622
reactant: 288610
fast: false
reversible: true
type: Reaction

562735
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 560155
type: Species

572094
kinetic law: 299110
product: 299098
reactant: 299085
reactant: 299074
fast: false
reversible: true
type: Reaction

561875
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 560155
type: Species

572954
kinetic law: 301188
product: 301176
product: 301164
reactant: 301152
fast: false
reversible: false
type: Reaction

288068
local parameters: 051898
local parameters: 051896
notes: k1*AMPAR_memb_slash_A845_star__B845_star_*CaMKII_slash_actCaMKII_minus_PSD-k2*CaMKII_slash_actCaMKII_minus_PSD_slash_CaMKII_slash_CaMKII_cplx
type: KineticLaw

052112
units: 284709
value: 7.2E-16
type: LocalParameter

052225
units: 284793
value: 2.011824E-17
type: LocalParameter

296466
stoichiometry: 1.0
species: 562655
type: SpeciesReference

051852
units: 284709
value: 9.0E-17
type: LocalParameter

562855
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 560155
type: Species

052267
units: 284793
value: 2.011824E-17
type: LocalParameter

051789
units: 284793
value: 1.6199838E-15
type: LocalParameter

563015
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 560155
type: Species

561395
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.00691
initial amount: NaN
in compartment: 560155
type: Species

568455
kinetic law: 289808
product: 289796
reactant: 289784
reactant: 289772
notes: PP2A does most of the dephosph of I1 at basal Ca levels. See the review by Cohen in Ann Rev Biochem 1989. For now, lets halve Km. k1 was 3.3e-6, now 6.6e-6
fast: false
reversible: true
type: Reaction

052640
units: 284793
value: 8.7498E-18
type: LocalParameter

291452
local parameters: 052112
local parameters: 052109
notes: k1*AMPAR_slash_A831_star_845_star__B*PP2B_slash_CaM_Ca_n_minus_CaNAB-k2*PP2B_slash_CaM_Ca_n_minus_CaNAB_slash_PP2B_sbo_18_sbc__slash_PP2B_sbo_18_sbc__cplx
type: KineticLaw

301994
stoichiometry: 1.0
species: 564515
type: SpeciesReference

299074
stoichiometry: 1.0
species: 565095
type: SpeciesReference

290775
local parameters: 052070
local parameters: 052067
notes: k1*PP1_PSD_slash_I1_star_*PP2B_slash_CaNAB_minus_Ca4-k2*PP2B_slash_CaNAB_minus_Ca4_slash_dephosph_inhib1_noCaM_PSD_slash_dephosph_inhib1_noCaM_PSD_cplx
type: KineticLaw

569475
kinetic law: 292667
product: 292655
product: 292643
reactant: 292631
fast: false
reversible: false
type: Reaction

052305
units: 284709
value: 7.2E-16
type: LocalParameter

565495
constant: false
boundary condition: true
has only substance units: false
initial concentration: 2.0
initial amount: NaN
in compartment: 560155
type: Species

297131
stoichiometry: 1.0
species: 565175
type: SpeciesReference

286194
stoichiometry: 1.0
species: 563635
type: SpeciesReference

294342
stoichiometry: 1.0
species: 561675
type: SpeciesReference

297239
stoichiometry: 1.0
species: 562655
type: SpeciesReference

292091
stoichiometry: 1.0
species: 564755
type: SpeciesReference

286207
stoichiometry: 1.0
species: 562535
type: SpeciesReference

560735
constant: false
boundary condition: false
has only substance units: false
initial concentration: 3.588E-215
initial amount: NaN
in compartment: 560175
type: Species

051811
units: 284793
value: 4.9998E-15
type: LocalParameter

291741
local parameters: 052130
local parameters: 052127
notes: k1*AMPAR_slash_A_B845_star_*PP2B_slash_CaM_Ca_n_minus_CaNAB-k2*PP2B_slash_CaM_Ca_n_minus_CaNAB_slash_PP2B_sbo_21_sbc__slash_PP2B_sbo_21_sbc__cplx
type: KineticLaw

288986
local parameters: 051946
notes: k3*CaMKII_slash_actCaMKII_minus_PSD_slash_CaMKII_sbo_9_sbc__slash_CaMKII_sbo_9_sbc__cplx
type: KineticLaw

052228
units: 284709
value: 7.2E-16
type: LocalParameter

563975
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 560175
type: Species

051705
units: 284793
value: 5.4E-21
type: LocalParameter

286523
stoichiometry: 1.0
species: 563455
type: SpeciesReference

297887
stoichiometry: 1.0
species: 562655
type: SpeciesReference

287418
stoichiometry: 1.0
species: 563655
type: SpeciesReference

292164
stoichiometry: 1.0
species: 561675
type: SpeciesReference

286255
stoichiometry: 1.0
species: 562555
type: SpeciesReference

301236
local parameters: 052762
local parameters: 052759
notes: k1*AMPAR_memb_slash_A831_star__B831_star_845_star_*PP1_PSD_slash_PP1_minus_active_PSD-k2*PP1_PSD_slash_PP1_minus_active_PSD_slash_PP1_sbo_25_sbc__slash_PP1_sbo_25_sbc__cplx
type: KineticLaw

562895
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 560155
type: Species

051919
units: 284709
value: 2.0E-17
type: LocalParameter

568495
kinetic law: 289905
product: 289893
reactant: 289881
reactant: 289869
notes: k1 changed from 3.3e-6 to 6.6e-6
fast: false
reversible: true
type: Reaction

571914
kinetic law: 298674
product: 298662
product: 298650
reactant: 298637
fast: false
reversible: false
type: Reaction

299146
stoichiometry: 1.0
species: 563755
type: SpeciesReference

287517
stoichiometry: 1.0
species: 565475
type: SpeciesReference

299701
stoichiometry: 1.0
species: 564035
type: SpeciesReference

288478
stoichiometry: 1.0
species: 565235
type: SpeciesReference

291296
stoichiometry: 1.0
species: 561675
type: SpeciesReference

296394
local parameters: 052438
local parameters: 052435
notes: k1*AMPAR_memb_slash_A_B845_star_*PKA_slash_PKA_minus_active-k2*PKA_slash_PKA_minus_active_slash_PKA_slash_PKA_cplx
type: KineticLaw

302150
stoichiometry: 1.0
species: 561035
type: SpeciesReference

565595
constant: false
boundary condition: true
has only substance units: false
initial concentration: 2.0
initial amount: NaN
in compartment: 560175
type: Species

286084
stoichiometry: 1.0
species: 562475
type: SpeciesReference

051850
units: 284709
value: 9.0E-17
type: LocalParameter

560235
constant: false
boundary condition: false
has only substance units: false
initial concentration: 20.0
initial amount: NaN
in compartment: 560155
type: Species

051706
units: 284793
value: 1.08E-20
type: LocalParameter

288889
local parameters: 051942
notes: k3*CaMKII_slash_actCaMKII_minus_PSD_slash_CaMKII_sbo_8_sbc__slash_CaMKII_sbo_8_sbc__cplx
type: KineticLaw

289289
stoichiometry: 1.0
species: 565155
type: SpeciesReference

570634
kinetic law: 295476
product: 295464
product: 295452
reactant: 295440
fast: false
reversible: false
type: Reaction

299435
stoichiometry: 1.0
species: 563755
type: SpeciesReference

301056
stoichiometry: 1.0
species: 564315
type: SpeciesReference

298443
stoichiometry: 1.0
species: 563775
type: SpeciesReference

290484
local parameters: 052049
local parameters: 052047
notes: k1*CaMKII_slash_CaMKII_star__star__star_*PP1_slash_PP1_minus_active-k2*PP1_slash_PP1_minus_active_slash_Deph_minus_thr286c_slash_Deph_minus_thr286c_cplx
type: KineticLaw

285278
local parameters: 051720
local parameters: 051718
notes: kf*CaMKII_slash_CaMKII_minus_PSD*CaM_slash_CaM_minus_Ca4_minus_PSD-kb*CaMKII_slash_CaMKII_minus_CaM_minus_PSD
type: KineticLaw

294402
stoichiometry: 1.0
species: 561675
type: SpeciesReference

301916
local parameters: 052821
local parameters: 052818
notes: k1*CaMKII_slash_CaMKII_minus_thr305_minus_PSD*PP1_PSD_slash_PP1_minus_active_PSD-k2*PP1_PSD_slash_PP1_minus_active_PSD_slash_Deph_minus_thr305a_slash_Deph_minus_thr305a_cplx
type: KineticLaw

302330
stoichiometry: 1.0
species: 564595
type: SpeciesReference

292236
stoichiometry: 1.0
species: 561975
type: SpeciesReference

561315
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 560155
type: Species

567215
kinetic law: 286910
product: 286898
product: 286886
reactant: 286874
fast: false
reversible: true
type: Reaction

295742
stoichiometry: 1.0
species: 564775
type: SpeciesReference

565235
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 560175
type: Species

294898
local parameters: 052341
notes: k3*PKA_slash_PKA_minus_active_slash_PKA_sbo_17_sbc__slash_PKA_sbo_17_sbc__cplx
type: KineticLaw

301956
stoichiometry: 1.0
species: 563755
type: SpeciesReference

289446
stoichiometry: 1.0
species: 565075
type: SpeciesReference

290207
stoichiometry: 1.0
species: 561475
type: SpeciesReference

570977
kinetic law: 296297
product: 296285
reactant: 296273
reactant: 296261
fast: false
reversible: true
type: Reaction

052306
units: 284709
value: 1.8E-16
type: LocalParameter

569474
kinetic law: 292619
product: 292607
reactant: 292595
reactant: 292583
fast: false
reversible: true
type: Reaction

287621
stoichiometry: 1.0
species: 565475
type: SpeciesReference

287569
stoichiometry: 1.0
species: 560355
type: SpeciesReference

289144
stoichiometry: 1.0
species: 560855
type: SpeciesReference

299580
stoichiometry: 1.0
species: 564015
type: SpeciesReference

291368
stoichiometry: 1.0
species: 561795
type: SpeciesReference

301635
stoichiometry: 1.0
species: 564435
type: SpeciesReference

052229
units: 284709
value: 1.8E-16
type: LocalParameter

564755
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 560155
type: Species

301020
stoichiometry: 1.0
species: 563755
type: SpeciesReference

284697
exponent: 1.0
scale: -6
multipler: 1.0
kind: MOLE
type: SBMLUnit

051810
units: 284793
value: 0.0
type: LocalParameter

563635
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 560155
type: Species

567475
kinetic law: 287430
product: 287418
reactant: 287406
fast: false
reversible: true
type: Reaction

299799
stoichiometry: 1.0
species: 564055
type: SpeciesReference

052119
units: 284709
value: 1.8E-16
type: LocalParameter

302042
stoichiometry: 1.0
species: 561035
type: SpeciesReference

566815
kinetic law: 285975
product: 285963
reactant: 285950
reactant: 285938
notes: This process is probably much more complicated and involves CaM. However, as I can\'t find detailed info I am bundling this into a single step. Based on Steemer and Klee pg 6863, the Kact is 0.5 uM. kf/kb = 1/(0.5 * 6e5)^2 = 1.11e-11
fast: false
reversible: true
type: Reaction

297288
stoichiometry: 1.0
species: 565235
type: SpeciesReference

295440
stoichiometry: 1.0
species: 562855
type: SpeciesReference

294451
stoichiometry: 1.0
species: 562455
type: SpeciesReference

565735
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 560155
type: Species

286608
stoichiometry: 1.0
species: 563615
type: SpeciesReference

051914
units: 284709
value: 2.0E-17
type: LocalParameter

286946
local parameters: 051828
local parameters: 051826
notes: kf*AMPAR_slash_A835_star_845_star__B835_star_845_star_-kb*AMPAR_slash_AMPAR_deg
type: KineticLaw

051856
units: 284709
value: 2.25E-16
type: LocalParameter

297779
stoichiometry: 1.0
species: 565195
type: SpeciesReference

286753
stoichiometry: 1.0
species: 565295
type: SpeciesReference

566895
kinetic law: 286169
product: 286157
reactant: 286145
reactant: 286133
notes: For now let us set this to the same Km (1e-7M) as site B. This gives kf/kb = .7e-7M * 1e6 / (6e5^2) : 1/(6e5^2) = 2e-13:2.77e-12 Smith et al have better values. They say that this is cooperative, so the consts are now kf/kb =8.3e-4
fast: false
reversible: true
type: Reaction

051969
units: 284793
value: 2.77776E-19
type: LocalParameter

567035
kinetic law: 286499
product: 286487
reactant: 286475
notes: Random rate.
fast: false
reversible: true
type: Reaction

294934
stoichiometry: 1.0
species: 562755
type: SpeciesReference

052118
units: 284709
value: 7.2E-16
type: LocalParameter

285975
local parameters: 051765
local parameters: 051763
notes: kf*Ca^2*PP2B_slash_CaNAB_minus_Ca2-kb*PP2B_slash_CaNAB_minus_Ca4
type: KineticLaw

298127
stoichiometry: 1.0
species: 563515
type: SpeciesReference

297452
stoichiometry: 1.0
species: 563275
type: SpeciesReference

294512
local parameters: 052313
notes: k3*PP2B_slash_CaM_Ca_n_minus_CaNAB_slash_dephosph_neurogranin_PSD_slash_dephosph_neurogranin_PSD_cplx
type: KineticLaw

572114
kinetic law: 299158
product: 299146
product: 299134
reactant: 299122
fast: false
reversible: false
type: Reaction

051915
units: 284709
value: 5.0E-18
type: LocalParameter

290665
stoichiometry: 1.0
species: 561635
type: SpeciesReference

051855
units: 284709
value: 1.26E-19
type: LocalParameter

052420
units: 284709
value: 2.16E-15
type: LocalParameter

569734
kinetic law: 293298
product: 293285
reactant: 293273
reactant: 293261
fast: false
reversible: true
type: Reaction

291560
stoichiometry: 1.0
species: 561835
type: SpeciesReference

300971
stoichiometry: 1.0
species: 565035
type: SpeciesReference

052159
units: 284793
value: 1.8106416E-16
type: LocalParameter

052047
units: 284793
value: 2.2062942E-16
type: LocalParameter

289070
stoichiometry: 1.0
species: 565595
type: SpeciesReference

563375
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 560155
type: Species

287983
stoichiometry: 1.0
species: 560595
type: SpeciesReference

288586
stoichiometry: 1.0
species: 565595
type: SpeciesReference

560835
constant: false
boundary condition: false
has only substance units: false
initial concentration: 2.04433333333333E-215
initial amount: NaN
in compartment: 560175
type: Species

287309
stoichiometry: 1.0
species: 564635
type: SpeciesReference

298818
local parameters: 052597
local parameters: 052594
notes: k1*AMPAR_memb_slash_A845_star__B845_star_*PP1_PSD_slash_PP1_minus_active_PSD-k2*PP1_PSD_slash_PP1_minus_active_PSD_slash_PP1_slash_PP1_cplx
type: KineticLaw

051966
units: 284709
value: 2.0E-17
type: LocalParameter

566655
kinetic law: 285609
product: 285596
reactant: 285584
reactant: 285572
notes: K3 = 21.5, K4 = 2.8. Assuming that the K4 step happens first, we get kb/kf = 2.8 uM = 1.68e6 so kf =6e-6 assuming kb = 10
fast: false
reversible: true
type: Reaction

052839
units: 284709
value: 1.26E-16
type: LocalParameter

290593
stoichiometry: 1.0
species: 561555
type: SpeciesReference

298067
stoichiometry: 1.0
species: 563435
type: SpeciesReference

288020
local parameters: 051894
notes: k3*CaMKII_slash_tot_minus_auto_minus_PSD_slash_auton_minus_286_minus_PSD_slash_auton_minus_286_minus_PSD_cplx
type: KineticLaw

566855
kinetic law: 286072
product: 286060
reactant: 286048
reactant: 286036
fast: false
reversible: true
type: Reaction

285120
stoichiometry: 1.0
species: 560495
type: SpeciesReference

293505
stoichiometry: 1.0
species: 562255
type: SpeciesReference

289556
stoichiometry: 1.0
species: 565595
type: SpeciesReference

289604
stoichiometry: 1.0
species: 560955
type: SpeciesReference

565015
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 560175
type: Species

051967
units: 284709
value: 5.0E-18
type: LocalParameter

295403
stoichiometry: 1.0
species: 562655
type: SpeciesReference

299932
local parameters: 052669
notes: k3*PP1_PSD_slash_PP1_minus_active_PSD_slash_PP1_sbo_11_sbc__slash_PP1_sbo_11_sbc__cplx
type: KineticLaw

291211
local parameters: 052095
notes: k3*PP2B_slash_CaM_Ca_n_minus_CaNAB_slash_dephosph_inhib1_PSD_slash_dephosph_inhib1_PSD_cplx
type: KineticLaw

565775
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 560175
type: Species

295634
stoichiometry: 1.0
species: 562895
type: SpeciesReference

052578
units: 284709
value: 2.5E-17
type: LocalParameter

051917
units: 284793
value: 2.77776E-19
type: LocalParameter

291633
stoichiometry: 1.0
species: 561855
type: SpeciesReference

561655
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 560155
type: Species

562555
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 560155
type: Species

564655
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 560155
type: Species

564715
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 560155
type: Species

567075
kinetic law: 286584
product: 286572
reactant: 286560
reactant: 286548
notes: For olf epi PDE1, affinity is 7 nM. Assume same for brain. Reaction should be pretty fast. Assume kb = 5/sec. Then kf = 5 / (0.007 * 6e5) = 1.2e-3
fast: false
reversible: true
type: Reaction

299182
stoichiometry: 1.0
species: 563755
type: SpeciesReference

566695
kinetic law: 285707
product: 285695
reactant: 285683
reactant: 285670
notes: Surprisingly, no direct info on rates from neurogranin at this time. These rates are based on GAP-43 binding studies. As GAP-43 and neurogranin share near identity in the CaM/PKC binding regions, and also similarity in phosph and dephosph rates, I am borrowing GAP-43 kinetic info. See Alexander et al JBC 262:13 6108-6113 1987
fast: false
reversible: true
type: Reaction

296646
stoichiometry: 1.0
species: 564975
type: SpeciesReference

051853
units: 284709
value: 3.5E-21
type: LocalParameter

052833
units: 284709
value: 5.22E-17
type: LocalParameter

568275
kinetic law: 289374
product: 289362
product: 289350
reactant: 289337
fast: false
reversible: false
type: Reaction

563075
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 560155
type: Species

290993
stoichiometry: 1.0
species: 561275
type: SpeciesReference

052115
units: 284793
value: 1.8106416E-16
type: LocalParameter

565175
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 560175
type: Species

297095
stoichiometry: 1.0
species: 565055
type: SpeciesReference

291524
stoichiometry: 1.0
species: 561675
type: SpeciesReference

288417
stoichiometry: 1.0
species: 565135
type: SpeciesReference

289217
stoichiometry: 1.0
species: 560875
type: SpeciesReference

286475
stoichiometry: 1.0
species: 563395
type: SpeciesReference

296358
stoichiometry: 1.0
species: 565095
type: SpeciesReference

052153
units: 284793
value: 1.8106416E-16
type: LocalParameter

052577
units: 284709
value: 1.0E-16
type: LocalParameter

051964
units: 284793
value: 2.77776E-19
type: LocalParameter

570214
kinetic law: 294463
product: 294451
reactant: 294439
reactant: 294427
notes: From Seki et al ABB 316(2):673-679
fast: false
reversible: true
type: Reaction

052464
units: 284709
value: 5.4E-16
type: LocalParameter

298236
local parameters: 052558
local parameters: 052555
notes: k1*AC_slash_cAMP*AC_slash_PDE1-k2*AC_slash_PDE1_slash_PDE1_slash_PDE1_cplx
type: KineticLaw

289832
stoichiometry: 1.0
species: 561275
type: SpeciesReference

292427
local parameters: 052176
local parameters: 052173
notes: k1*AMPAR_slash_A835_star_845_star__B835_star_845_star_*PP2B_slash_CaM_Ca_n_minus_CaNAB-k2*PP2B_slash_CaM_Ca_n_minus_CaNAB_slash_PP2B_sbo_28_sbc__slash_PP2B_sbo_28_sbc__cplx
type: KineticLaw

290848
stoichiometry: 1.0
species: 561675
type: SpeciesReference

296986
stoichiometry: 1.0
species: 563175
type: SpeciesReference

565435
constant: true
boundary condition: true
has only substance units: false
initial concentration: 0.08
initial amount: NaN
in compartment: 560155
type: Species

563595
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 560155
type: Species

573294
kinetic law: 302018
product: 302006
reactant: 301994
reactant: 301982
notes: Rates from Huang et al ABB 305:2 570-580 1993
fast: false
reversible: true
type: Reaction

052423
units: 284793
value: 3.5998992E-16
type: LocalParameter

564255
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 560175
type: Species

561035
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 560155
type: Species

299749
stoichiometry: 1.0
species: 565055
type: SpeciesReference

298370
stoichiometry: 1.0
species: 563575
type: SpeciesReference

287054
local parameters: 051837
local parameters: 051835
notes: kf*AMPAR_slash_A845_star__B845_star_-kb*AMPAR_slash_AMPAR_deg
type: KineticLaw

293298
local parameters: 052234
local parameters: 052231
notes: k1*AMPAR_memb_slash_A831_star_845_star__B845_star_*PP2B_slash_CaM_Ca_n_minus_CaNAB-k2*PP2B_slash_CaM_Ca_n_minus_CaNAB_slash_PP2B_sbo_4_sbc__slash_PP2B_sbo_4_sbc__cplx
type: KineticLaw

294074
local parameters: 052284
local parameters: 052281
notes: k1*AMPAR_memb_slash_A835_star_845_star__B835_star_845_star_*PP2B_slash_CaM_Ca_n_minus_CaNAB-k2*PP2B_slash_CaM_Ca_n_minus_CaNAB_slash_PP2B_sbo_12_sbc__slash_PP2B_sbo_12_sbc__cplx
type: KineticLaw

569794
kinetic law: 293444
product: 293432
product: 293420
reactant: 293408
fast: false
reversible: false
type: Reaction

286862
local parameters: 051822
local parameters: 051820
notes: kf*AMPAR_memb_slash_A831_star__B-kb*AMPAR_slash_A831_star__B*AMPAR_memb_slash_Anchor
type: KineticLaw

300415
local parameters: 052703
notes: k3*PP1_PSD_slash_PP1_minus_active_PSD_slash_PP1_sbo_16_sbc__slash_PP1_sbo_16_sbc__cplx
type: KineticLaw

561075
constant: false
boundary condition: false
has only substance units: false
initial concentration: 26.3333333333333
initial amount: NaN
in compartment: 560175
type: Species

301466
stoichiometry: 1.0
species: 563755
type: SpeciesReference

561695
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 560155
type: Species

285047
local parameters: 051705
local parameters: 051703
notes: kf*CaMKII_slash_CaMKII_minus_PSD-kb*CaMKII_slash_CaMKII*CaMKII_slash_NMDAR
type: KineticLaw

052463
units: 284709
value: 2.16E-15
type: LocalParameter

571434
kinetic law: 297513
product: 297501
product: 297488
reactant: 297476
fast: false
reversible: false
type: Reaction

573254
kinetic law: 301916
product: 301903
reactant: 301890
reactant: 301877
fast: false
reversible: true
type: Reaction

296033
stoichiometry: 1.0
species: 564755
type: SpeciesReference

296974
local parameters: 052477
local parameters: 052474
notes: k1*AMPAR_memb_slash_A831_star__B*PKA_slash_PKA_minus_active-k2*PKA_slash_PKA_minus_active_slash_PKA_sbo_6_sbc__slash_PKA_sbo_6_sbc__cplx
type: KineticLaw

302006
stoichiometry: 1.0
species: 564535
type: SpeciesReference

568895
kinetic law: 290872
product: 290860
reactant: 290848
reactant: 290836
notes: From Seki et al ABB 316(2):673-679
fast: false
reversible: true
type: Reaction

051859
units: 284709
value: 9.0E-15
type: LocalParameter

570254
kinetic law: 294560
product: 294548
reactant: 294536
reactant: 294524
notes: Same rates as PKA-phosph-I1
fast: false
reversible: true
type: Reaction

052709
units: 284709
value: 6.8E-18
type: LocalParameter

300717
stoichiometry: 1.0
species: 565175
type: SpeciesReference

299652
stoichiometry: 1.0
species: 565155
type: SpeciesReference

051911
units: 284793
value: 2.77776E-19
type: LocalParameter

289181
local parameters: 051957
notes: k3*CaMKII_slash_actCaMKII_minus_PSD_slash_CaMKII_sbo_11_sbc__slash_CaMKII_sbo_11_sbc__cplx
type: KineticLaw

052222
units: 284709
value: 1.8E-16
type: LocalParameter

294621
stoichiometry: 1.0
species: 561275
type: SpeciesReference

051962
units: 284709
value: 5.0E-18
type: LocalParameter

297179
stoichiometry: 1.0
species: 563215
type: SpeciesReference

296249
local parameters: 052427
notes: k3*PKA_slash_PKA_minus_active_slash_PKA_sbo_30_sbc__slash_PKA_sbo_30_sbc__cplx
type: KineticLaw

572734
kinetic law: 300657
product: 300645
reactant: 300633
reactant: 300621
fast: false
reversible: true
type: Reaction

572214
kinetic law: 299399
product: 299387
reactant: 299375
reactant: 299363
fast: false
reversible: true
type: Reaction

288176
stoichiometry: 1.0
species: 560655
type: SpeciesReference

298175
stoichiometry: 1.0
species: 563495
type: SpeciesReference

287669
stoichiometry: 1.0
species: 560375
type: SpeciesReference

052156
units: 284709
value: 7.2E-16
type: LocalParameter

294209
stoichiometry: 1.0
species: 561675
type: SpeciesReference

298927
stoichiometry: 1.0
species: 563875
type: SpeciesReference

561135
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 560175
type: Species

293881
local parameters: 052270
local parameters: 052267
notes: k1*AMPAR_memb_slash_A_B831_star_845_star_*PP2B_slash_CaM_Ca_n_minus_CaNAB-k2*PP2B_slash_CaM_Ca_n_minus_CaNAB_slash_PP2B_sbo_10_sbc__slash_PP2B_sbo_10_sbc__cplx
type: KineticLaw

052421
units: 284709
value: 5.4E-16
type: LocalParameter

051858
units: 284709
value: 2.25E-16
type: LocalParameter

285815
stoichiometry: 1.0
species: 561255
type: SpeciesReference

052221
units: 284709
value: 7.2E-16
type: LocalParameter

052836
units: 284793
value: 5.507838E-18
type: LocalParameter

293141
stoichiometry: 1.0
species: 561675
type: SpeciesReference

052574
units: 284793
value: 6.2502E-17
type: LocalParameter

561615
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 560155
type: Species

284937
stoichiometry: 1.0
species: 560275
type: SpeciesReference

052049
units: 284709
value: 9.0E-16
type: LocalParameter

052157
units: 284709
value: 1.8E-16
type: LocalParameter

286145
stoichiometry: 1.0
species: 563635
type: SpeciesReference

292788
stoichiometry: 1.0
species: 561675
type: SpeciesReference

052460
units: 284793
value: 3.999888E-17
type: LocalParameter

290195
local parameters: 052025
local parameters: 052023
notes: k1*CaMKII_slash_CaMKII_minus_thr286_star__minus_CaM*PP1_slash_PP1_minus_active-k2*PP1_slash_PP1_minus_active_slash_Deph_minus_thr286_slash_Deph_minus_thr286_cplx
type: KineticLaw

289592
stoichiometry: 1.0
species: 565615
type: SpeciesReference

284877
stoichiometry: 1.0
species: 560235
type: SpeciesReference

300100
stoichiometry: 1.0
species: 565115
type: SpeciesReference

298504
stoichiometry: 1.0
species: 563755
type: SpeciesReference

290013
stoichiometry: 1.0
species: 561415
type: SpeciesReference

052064
units: 284709
value: 1.224E-17
type: LocalParameter

299664
stoichiometry: 1.0
species: 563755
type: SpeciesReference

298698
stoichiometry: 1.0
species: 563755
type: SpeciesReference

052015
units: 284709
value: 1.8E-16
type: LocalParameter

301478
local parameters: 052779
notes: k3*PP1_PSD_slash_PP1_minus_active_PSD_slash_PP1_sbo_27_sbc__slash_PP1_sbo_27_sbc__cplx
type: KineticLaw

295512
stoichiometry: 1.0
species: 562875
type: SpeciesReference

052766
units: 284793
value: 8.7498E-18
type: LocalParameter

560435
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 560175
type: Species

292897
stoichiometry: 1.0
species: 562135
type: SpeciesReference

287922
local parameters: 051889
notes: k3*CaMKII_slash_tot_minus_auto_minus_PSD_slash_auton_minus_305_minus_PSD_slash_auton_minus_305_minus_PSD_cplx
type: KineticLaw

287066
stoichiometry: 1.0
species: 564815
type: SpeciesReference

560475
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 560175
type: Species

051946
units: 284709
value: 5.0E-18
type: LocalParameter

561175
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 560155
type: Species

297646
stoichiometry: 1.0
species: 563315
type: SpeciesReference

560995
constant: false
boundary condition: false
has only substance units: false
initial concentration: 26.3333333333333
initial amount: NaN
in compartment: 560155
type: Species

563115
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 560155
type: Species

052065
units: 284709
value: 3.06E-18
type: LocalParameter

286036
stoichiometry: 1.0
species: 561255
type: SpeciesReference

289374
local parameters: 051967
notes: k3*CaMKII_slash_actCaMKII_minus_PSD_slash_CaMKII_sbo_13_sbc__slash_CaMKII_sbo_13_sbc__cplx
type: KineticLaw

288658
stoichiometry: 1.0
species: 560755
type: SpeciesReference

052726
units: 284793
value: 8.7498E-18
type: LocalParameter

563155
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 560155
type: Species

563455
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.555555555555556
initial amount: NaN
in compartment: 560155
type: Species

052166
units: 284793
value: 1.8106416E-16
type: LocalParameter

051723
units: 284709
value: 1.0E-18
type: LocalParameter

292619
local parameters: 052189
local parameters: 052186
notes: k1*AMPAR_slash_A831_star_845_star__B845_star_*PP2B_slash_CaM_Ca_n_minus_CaNAB-k2*PP2B_slash_CaM_Ca_n_minus_CaNAB_slash_PP2B_sbo_30_sbc__slash_PP2B_sbo_30_sbc__cplx
type: KineticLaw

295524
local parameters: 052384
local parameters: 052381
notes: k1*AMPAR_slash_A831_star__B831_star_*PKA_slash_PKA_minus_active-k2*PKA_slash_PKA_minus_active_slash_PKA_sbo_23_sbc__slash_PKA_sbo_23_sbc__cplx
type: KineticLaw

560195
constant: true
size: 5.0E-15
spatial dimensions: 3.0
type: Compartment

567595
kinetic law: 287729
product: 287717
product: 287705
reactant: 287693
fast: false
reversible: false
type: Reaction

052699
units: 284793
value: 8.7498E-18
type: LocalParameter

299908
stoichiometry: 1.0
species: 564975
type: SpeciesReference

291512
stoichiometry: 1.0
species: 564895
type: SpeciesReference

302378
stoichiometry: 1.0
species: 561095
type: SpeciesReference

052815
units: 284709
value: 3.5E-18
type: LocalParameter

286729
stoichiometry: 1.0
species: 565015
type: SpeciesReference

294560
local parameters: 052319
local parameters: 052316
notes: k1*AC_slash_cAMP_minus_PDE*PKA_slash_PKA_minus_active-k2*PKA_slash_PKA_minus_active_slash_phosph_minus_PDE_slash_phosph_minus_PDE_cplx
type: KineticLaw

051720
units: 284709
value: 0.0
type: LocalParameter

566635
kinetic law: 285559
product: 285547
reactant: 285535
reactant: 285523
notes: Lets use the fast rate consts here. Since the rates are so different, I am not sure whether the order is relevant. These correspond to the TR2C fragment. We use the Martin et al rates here, plus the Drabicowski binding consts. All are scaled by 3X to cell temp. kf = 2e-10 kb = 72 Stemmer & Klee: K1=.9, K2=1.1. Assume 1.0uM for both. kb/kf=3.6e11. If kb=72, kf = 2e-10 (Exactly the same !)....
fast: false
reversible: true
type: Reaction

286487
stoichiometry: 1.0
species: 563415
type: SpeciesReference

288695
local parameters: 051930
notes: k3*CaMKII_slash_actCaMKII_minus_PSD_slash_CaMKII_sbo_6_sbc__slash_CaMKII_sbo_6_sbc__cplx
type: KineticLaw

560915
constant: false
boundary condition: false
has only substance units: false
initial concentration: 2.04433333333333E-215
initial amount: NaN
in compartment: 560175
type: Species

300669
stoichiometry: 1.0
species: 564235
type: SpeciesReference

289580
stoichiometry: 1.0
species: 560515
type: SpeciesReference

052169
units: 284709
value: 7.2E-16
type: LocalParameter

284901
local parameters: 051696
local parameters: 051693
notes: kf*CaM_slash_CaM_minus_Ca4*CaMKII_slash_CaMKII-kb*CaMKII_slash_CaMKII_minus_CaM
type: KineticLaw

294958
stoichiometry: 1.0
species: 562755
type: SpeciesReference

292336
stoichiometry: 1.0
species: 561995
type: SpeciesReference

569075
kinetic law: 291308
product: 291296
product: 291284
reactant: 291272
fast: false
reversible: false
type: Reaction

563515
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 560155
type: Species

569754
kinetic law: 293346
product: 293334
product: 293322
reactant: 293310
fast: false
reversible: false
type: Reaction

292959
local parameters: 052210
notes: k3*PP2B_slash_CaM_Ca_n_minus_CaNAB_slash_PP2B_slash_PP2B_cplx
type: KineticLaw

297574
stoichiometry: 1.0
species: 563295
type: SpeciesReference

295561
stoichiometry: 1.0
species: 562655
type: SpeciesReference

052067
units: 284793
value: 3.420036E-19
type: LocalParameter

289058
stoichiometry: 1.0
species: 565075
type: SpeciesReference

569035
kinetic law: 291211
product: 291199
product: 291187
reactant: 291175
fast: false
reversible: false
type: Reaction

051948
units: 284793
value: 2.77776E-19
type: LocalParameter

051721
units: 284793
value: 1.00002E-14
type: LocalParameter

302318
local parameters: 052857
local parameters: 052854
notes: k1*CaM_slash_neurogranin_PSD*PKC_minus_active-k2*PKC_minus_active_slash_PKC_minus_phosph_minus_neurogranin_PSD_slash_PKC_minus_phosph_minus_neurogranin_PSD_cplx
type: KineticLaw

290520
stoichiometry: 1.0
species: 561455
type: SpeciesReference

052350
units: 284793
value: 3.5998992E-16
type: LocalParameter

285731
stoichiometry: 1.0
species: 561115
type: SpeciesReference

052014
units: 284709
value: 7.50006E-16
type: LocalParameter

285352
stoichiometry: 2.0
species: 560215
type: SpeciesReference

567655
kinetic law: 287874
product: 287861
reactant: 287849
reactant: 287837
fast: false
reversible: true
type: Reaction

292007
stoichiometry: 1.0
species: 561675
type: SpeciesReference

291066
local parameters: 052088
local parameters: 052085
notes: k1*PP1_slash_PP1_minus_I1_star_*PP2B_slash_CaM_Ca_n_minus_CaNAB-k2*PP2B_slash_CaM_Ca_n_minus_CaNAB_slash_dephosph_minus_PP1_minus_I_star__slash_dephosph_minus_PP1_minus_I_star__cplx
type: KineticLaw

564295
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 560175
type: Species

299255
local parameters: 052624
notes: k3*PP1_PSD_slash_PP1_minus_active_PSD_slash_PP1_sbo_4_sbc__slash_PP1_sbo_4_sbc__cplx
type: KineticLaw

294633
stoichiometry: 1.0
species: 562655
type: SpeciesReference

293688
local parameters: 052258
local parameters: 052255
notes: k1*AMPAR_memb_slash_A845_star__B831_star_845_star_*PP2B_slash_CaM_Ca_n_minus_CaNAB-k2*PP2B_slash_CaM_Ca_n_minus_CaNAB_slash_PP2B_sbo_8_sbc__slash_PP2B_sbo_8_sbc__cplx
type: KineticLaw

285559
local parameters: 051738
local parameters: 051736
notes: kf*CaM_slash_CaM_minus_PSD*Ca_minus_PSD^2-kb*CaM_slash_CaM_minus_TR2_minus_Ca2_minus_PSD
type: KineticLaw

294597
stoichiometry: 1.0
species: 562655
type: SpeciesReference

291392
stoichiometry: 1.0
species: 561675
type: SpeciesReference

295270
stoichiometry: 1.0
species: 562655
type: SpeciesReference

052011
units: 284793
value: 6.4584E-18
type: LocalParameter

051726
units: 284709
value: 6.48E-15
type: LocalParameter

567995
kinetic law: 288695
product: 288682
product: 288670
reactant: 288658
fast: false
reversible: false
type: Reaction

298806
stoichiometry: 1.0
species: 563855
type: SpeciesReference

285071
stoichiometry: 1.0
species: 560495
type: SpeciesReference

294257
stoichiometry: 1.0
species: 562415
type: SpeciesReference

565095
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 560175
type: Species

284986
stoichiometry: 1.0
species: 560495
type: SpeciesReference

570694
kinetic law: 295622
product: 295610
reactant: 295598
reactant: 295585
fast: false
reversible: true
type: Reaction

052812
units: 284709
value: 1.4E-17
type: LocalParameter

566995
kinetic law: 286415
product: 286403
reactant: 286391
reactant: 286378
notes: This has to be set to zero for matching the expts in vitro. In vivo we need to consider the inhibition though. kf = 1e-5 kb = 1
fast: false
reversible: true
type: Reaction

052330
units: 284793
value: 5.99994E-17
type: LocalParameter

285316
stoichiometry: 1.0
species: 560555
type: SpeciesReference

052617
units: 284709
value: 6.8E-18
type: LocalParameter

052696
units: 284709
value: 6.8E-18
type: LocalParameter

297058
stoichiometry: 1.0
species: 563195
type: SpeciesReference

286109
stoichiometry: 1.0
species: 562495
type: SpeciesReference

561255
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 560155
type: Species

286439
stoichiometry: 1.0
species: 562115
type: SpeciesReference

571314
kinetic law: 297215
product: 297203
product: 297191
reactant: 297179
fast: false
reversible: false
type: Reaction

297537
stoichiometry: 1.0
species: 562655
type: SpeciesReference

051727
units: 284793
value: 3.2400162E-16
type: LocalParameter

298540
stoichiometry: 1.0
species: 563795
type: SpeciesReference

299616
stoichiometry: 1.0
species: 565135
type: SpeciesReference

294318
local parameters: 052299
notes: k3*PP2B_slash_CaM_Ca_n_minus_CaNAB_slash_PP2B_sbo_14_sbc__slash_PP2B_sbo_14_sbc__cplx
type: KineticLaw

285510
local parameters: 051735
local parameters: 051733
notes: kf*CaM_slash_neurogranin_star_-kb*CaM_slash_neurogranin
type: KineticLaw

293978
local parameters: 052277
local parameters: 052274
notes: k1*AMPAR_memb_slash_A845_star__B831_star_*PP2B_slash_CaM_Ca_n_minus_CaNAB-k2*PP2B_slash_CaM_Ca_n_minus_CaNAB_slash_PP2B_sbo_11_sbc__slash_PP2B_sbo_11_sbc__cplx
type: KineticLaw

289965
stoichiometry: 1.0
species: 563695
type: SpeciesReference

568675
kinetic law: 290339
product: 290327
product: 290315
reactant: 290303
fast: false
reversible: false
type: Reaction

562315
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 560155
type: Species

052061
units: 284793
value: 3.0779838E-18
type: LocalParameter

292401
stoichiometry: 1.0
species: 561675
type: SpeciesReference

302078
stoichiometry: 1.0
species: 561015
type: SpeciesReference

052618
units: 284709
value: 1.7E-18
type: LocalParameter

563195
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 560155
type: Species

565055
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 560175
type: Species

567615
kinetic law: 287777
product: 287765
reactant: 287753
reactant: 287741
fast: false
reversible: true
type: Reaction

570274
kinetic law: 294609
product: 294597
product: 294584
reactant: 294572
fast: false
reversible: false
type: Reaction

293020
stoichiometry: 1.0
species: 562155
type: SpeciesReference

295949
stoichiometry: 1.0
species: 562655
type: SpeciesReference

299787
local parameters: 052661
local parameters: 052658
notes: k1*AMPAR_memb_slash_A831_star_845_star__B*PP1_PSD_slash_PP1_minus_active_PSD-k2*PP1_PSD_slash_PP1_minus_active_PSD_slash_PP1_sbo_10_sbc__slash_PP1_sbo_10_sbc__cplx
type: KineticLaw

296225
stoichiometry: 1.0
species: 564795
type: SpeciesReference

287789
stoichiometry: 1.0
species: 560395
type: SpeciesReference

052353
units: 284709
value: 2.16E-15
type: LocalParameter

296153
local parameters: 052421
notes: k3*PKA_slash_PKA_minus_active_slash_PKA_sbo_29_sbc__slash_PKA_sbo_29_sbc__cplx
type: KineticLaw

051724
units: 284745
value: 6.47990604E-15
type: LocalParameter

562075
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 560155
type: Species

052729
units: 284709
value: 1.4E-17
type: LocalParameter

301816
local parameters: 052812
local parameters: 052809
notes: k1*AMPAR_memb_slash_A831_star__B831_star_*PP1_PSD_slash_PP1_minus_active_PSD-k2*PP1_PSD_slash_PP1_minus_active_PSD_slash_PP1_sbo_31_sbc__slash_PP1_sbo_31_sbc__cplx
type: KineticLaw

296865
stoichiometry: 1.0
species: 563155
type: SpeciesReference

566915
kinetic law: 286219
product: 286207
reactant: 286194
reactant: 286181
fast: false
reversible: true
type: Reaction

292475
local parameters: 052177
notes: k3*PP2B_slash_CaM_Ca_n_minus_CaNAB_slash_PP2B_sbo_28_sbc__slash_PP2B_sbo_28_sbc__cplx
type: KineticLaw

562675
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 560155
type: Species

291669
stoichiometry: 1.0
species: 564915
type: SpeciesReference

561535
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 560155
type: Species

294196
stoichiometry: 1.0
species: 565075
type: SpeciesReference

572514
kinetic law: 300124
product: 300112
product: 300100
reactant: 300088
fast: false
reversible: false
type: Reaction

052354
units: 284709
value: 5.4E-16
type: LocalParameter

564975
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 560175
type: Species

294994
local parameters: 052348
notes: k3*PKA_slash_PKA_minus_active_slash_PKA_sbo_16_sbc__slash_PKA_sbo_16_sbc__cplx
type: KineticLaw

563675
constant: false
boundary condition: false
has only substance units: false
initial concentration: 4.0
initial amount: NaN
in compartment: 560175
type: Species

561575
constant: false
boundary condition: false
has only substance units: false
initial concentration: 1.0
initial amount: NaN
in compartment: 560155
type: Species

292375
local parameters: 052170
notes: k3*PP2B_slash_CaM_Ca_n_minus_CaNAB_slash_PP2B_sbo_27_sbc__slash_PP2B_sbo_27_sbc__cplx
type: KineticLaw

571674
kinetic law: 298091
product: 298079
product: 298067
reactant: 298055
fast: false
reversible: false
type: Reaction

295670
local parameters: 052391
notes: k3*PKA_slash_PKA_minus_active_slash_PKA_sbo_24_sbc__slash_PKA_sbo_24_sbc__cplx
type: KineticLaw

300621
stoichiometry: 1.0
species: 565075
type: SpeciesReference

564935
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 560155
type: Species

285926
local parameters: 051762
local parameters: 051760
notes: kf*PP1_slash_PP1_minus_I1-kb*PP1_slash_PP1_minus_active*PP1_slash_I1
type: KineticLaw

285426
local parameters: 051729
local parameters: 051727
notes: kf*CaM_slash_CaM_minus_TR2_minus_Ca2*Ca-kb*CaM_slash_CaM_minus_Ca3
type: KineticLaw

052769
units: 284709
value: 1.4E-17
type: LocalParameter

562035
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 560155
type: Species

566955
kinetic law: 286315
product: 286303
product: 286291
reactant: 286279
notes: This has to be fast, as the activation of PKA by cAMP is also fast. kf was 10
fast: false
reversible: true
type: Reaction

052697
units: 284709
value: 1.7E-18
type: LocalParameter

301587
stoichiometry: 1.0
species: 565195
type: SpeciesReference

292261
stoichiometry: 1.0
species: 561675
type: SpeciesReference

290956
stoichiometry: 1.0
species: 561715
type: SpeciesReference

290412
stoichiometry: 1.0
species: 560315
type: SpeciesReference

293820
stoichiometry: 1.0
species: 561675
type: SpeciesReference

572774
kinetic law: 300753
product: 300741
reactant: 300729
reactant: 300717
fast: false
reversible: true
type: Reaction

052356
units: 284793
value: 3.5998992E-16
type: LocalParameter

291284
stoichiometry: 1.0
species: 563735
type: SpeciesReference

571194
kinetic law: 296925
product: 296913
product: 296901
reactant: 296889
fast: false
reversible: false
type: Reaction

287530
local parameters: 051868
notes: k3*CaMKII_slash_tot_CaM_CaMKII_slash_CaM_act_305_slash_CaM_act_305_cplx
type: KineticLaw

565275
constant: false
boundary condition: false
has only substance units: false
initial concentration: 3.5
initial amount: NaN
in compartment: 560175
type: Species

292800
stoichiometry: 1.0
species: 562095
type: SpeciesReference

052334
units: 284709
value: 8.1E-16
type: LocalParameter

052547
units: 284709
value: 9.0E-16
type: LocalParameter

287285
local parameters: 051852
local parameters: 051850
notes: kf*AMPAR_slash_AMPAR_bulk-kb*AMPAR_slash_A_B
type: KineticLaw

296586
local parameters: 052450
local parameters: 052447
notes: k1*AMPAR_memb_slash_A_B*PKA_slash_PKA_minus_active-k2*PKA_slash_PKA_minus_active_slash_PKA_sbo_2_sbc__slash_PKA_sbo_2_sbc__cplx
type: KineticLaw

295006
stoichiometry: 1.0
species: 564875
type: SpeciesReference

052285
units: 284709
value: 1.8E-16
type: LocalParameter

287406
stoichiometry: 1.0
species: 565455
type: SpeciesReference

292511
stoichiometry: 1.0
species: 562035
type: SpeciesReference

300933
stoichiometry: 1.0
species: 564295
type: SpeciesReference

561855
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 560155
type: Species

052397
units: 284709
value: 5.4E-16
type: LocalParameter

296901
stoichiometry: 1.0
species: 565215
type: SpeciesReference

302222
local parameters: 052848
local parameters: 052845
notes: k1*AC_slash_AC2*PKC_minus_active-k2*PKC_minus_active_slash_phosph_minus_AC2_slash_phosph_minus_AC2_cplx
type: KineticLaw

297851
local parameters: 052534
local parameters: 052531
notes: k1*AMPAR_memb_slash_A831_star__B831_star_*PKA_slash_PKA_minus_active-k2*PKA_slash_PKA_minus_active_slash_PKA_sbo_15_sbc__slash_PKA_sbo_15_sbc__cplx
type: KineticLaw

568395
kinetic law: 289664
product: 289652
product: 289640
reactant: 289628
fast: false
reversible: false
type: Reaction

291983
local parameters: 052144
notes: k3*PP2B_slash_CaM_Ca_n_minus_CaNAB_slash_PP2B_sbo_23_sbc__slash_PP2B_sbo_23_sbc__cplx
type: KineticLaw

052546
units: 284709
value: 3.6E-15
type: LocalParameter

286219
local parameters: 051780
local parameters: 051778
notes: kf*PKA_slash_R2C2_minus_cAMP2*AC_slash_cAMP-kb*PKA_slash_R2C2_minus_cAMP3
type: KineticLaw

299896
stoichiometry: 1.0
species: 564075
type: SpeciesReference

287898
stoichiometry: 1.0
species: 560455
type: SpeciesReference

300367
local parameters: 052702
local parameters: 052699
notes: k1*AMPAR_memb_slash_A835_star_845_star__B835_star_845_star_*PP1_PSD_slash_PP1_minus_active_PSD-k2*PP1_PSD_slash_PP1_minus_active_PSD_slash_PP1_sbo_16_sbc__slash_PP1_sbo_16_sbc__cplx
type: KineticLaw

051771
units: 284709
value: 9.0E-17
type: LocalParameter

298843
stoichiometry: 1.0
species: 565095
type: SpeciesReference

561815
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 560155
type: Species

052614
units: 284793
value: 8.7498E-18
type: LocalParameter

052652
units: 284793
value: 8.7498E-18
type: LocalParameter

300945
local parameters: 052742
local parameters: 052739
notes: k1*AMPAR_memb_slash_A845_star__B831_star_*PP1_PSD_slash_PP1_minus_active_PSD-k2*PP1_PSD_slash_PP1_minus_active_PSD_slash_PP1_sbo_22_sbc__slash_PP1_sbo_22_sbc__cplx
type: KineticLaw

052284
units: 284709
value: 7.2E-16
type: LocalParameter

052396
units: 284709
value: 2.16E-15
type: LocalParameter

289652
stoichiometry: 1.0
species: 565615
type: SpeciesReference

301852
stoichiometry: 1.0
species: 563755
type: SpeciesReference

565535
constant: false
boundary condition: false
has only substance units: false
initial concentration: 2.0
initial amount: NaN
in compartment: 560155
type: Species

292583
stoichiometry: 1.0
species: 564775
type: SpeciesReference

291139
stoichiometry: 1.0
species: 561675
type: SpeciesReference

288236
stoichiometry: 1.0
species: 565595
type: SpeciesReference

563875
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 560175
type: Species

565575
constant: false
boundary condition: false
has only substance units: false
initial concentration: 2.0
initial amount: NaN
in compartment: 560175
type: Species

293869
stoichiometry: 1.0
species: 562335
type: SpeciesReference

571494
kinetic law: 297658
product: 297646
reactant: 297634
reactant: 297622
fast: false
reversible: true
type: Reaction

299507
stoichiometry: 1.0
species: 563995
type: SpeciesReference

052690
units: 284709
value: 1.7E-18
type: LocalParameter

295162
stoichiometry: 1.0
species: 564935
type: SpeciesReference

284685
exponent: -1.0
scale: 0
multipler: 1.0
kind: LITRE
type: SBMLUnit

568355
kinetic law: 289568
product: 289556
product: 289544
reactant: 289532
fast: false
reversible: false
type: Reaction

052611
units: 284709
value: 1.7E-18
type: LocalParameter

284721
exponent: 1.0
scale: 0
multipler: 1.0
kind: LITRE
type: SBMLUnit

290568
stoichiometry: 1.0
species: 561555
type: SpeciesReference

301007
stoichiometry: 1.0
species: 565000
type: SpeciesReference

301695
stoichiometry: 1.0
species: 563755
type: SpeciesReference

561215
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 560175
type: Species

563935
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 560175
type: Species

562255
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 560155
type: Species

052549
units: 284793
value: 4.5359838E-16
type: LocalParameter

052399
units: 284793
value: 3.5998992E-16
type: LocalParameter

570414
kinetic law: 294946
product: 294934
reactant: 294922
reactant: 294910
fast: false
reversible: true
type: Reaction

571114
kinetic law: 296732
product: 296719
product: 296707
reactant: 296695
fast: false
reversible: false
type: Reaction

287139
stoichiometry: 1.0
species: 565235
type: SpeciesReference

293640
local parameters: 052253
notes: k3*PP2B_slash_CaM_Ca_n_minus_CaNAB_slash_PP2B_sbo_7_sbc__slash_PP2B_sbo_7_sbc__cplx
type: KineticLaw

294886
stoichiometry: 1.0
species: 562655
type: SpeciesReference

290629
local parameters: 052059
notes: k3*PP1_slash_PP1_minus_active_slash_Deph_minus_thr305a_slash_Deph_minus_thr305a_cplx
type: KineticLaw

297911
stoichiometry: 1.0
species: 565355
type: SpeciesReference

569334
kinetic law: 292176
product: 292164
product: 292152
reactant: 292140
fast: false
reversible: false
type: Reaction

571154
kinetic law: 296828
product: 296816
product: 296804
reactant: 296792
fast: false
reversible: false
type: Reaction

292727
stoichiometry: 1.0
species: 562075
type: SpeciesReference

285596
stoichiometry: 1.0
species: 561215
type: SpeciesReference

571894
kinetic law: 298625
product: 298613
reactant: 298601
reactant: 298589
fast: false
reversible: true
type: Reaction

292910
local parameters: 052209
local parameters: 052206
notes: k1*AMPAR_memb_slash_A845_star__B845_star_*PP2B_slash_CaM_Ca_n_minus_CaNAB-k2*PP2B_slash_CaM_Ca_n_minus_CaNAB_slash_PP2B_slash_PP2B_cplx
type: KineticLaw

296756
stoichiometry: 1.0
species: 562655
type: SpeciesReference

052359
units: 284709
value: 2.16E-15
type: LocalParameter

052693
units: 284793
value: 8.7498E-18
type: LocalParameter

568035
kinetic law: 288792
product: 288780
product: 288768
reactant: 288755
fast: false
reversible: false
type: Reaction

300873
stoichiometry: 1.0
species: 565135
type: SpeciesReference

052333
units: 284709
value: 3.24E-15
type: LocalParameter

293068
stoichiometry: 1.0
species: 565095
type: SpeciesReference

293322
stoichiometry: 1.0
species: 565155
type: SpeciesReference

284757
exponent: 3.0
scale: 0
multipler: 1.0
kind: LITRE
type: SBMLUnit

292224
local parameters: 052162
local parameters: 052159
notes: k1*AMPAR_slash_A831_star_845_star__B845_star_*PP2B_slash_CaM_Ca_n_minus_CaNAB-k2*PP2B_slash_CaM_Ca_n_minus_CaNAB_slash_PP2B_sbo_26_sbc__slash_PP2B_sbo_26_sbc__cplx
type: KineticLaw

289917
stoichiometry: 1.0
species: 561395
type: SpeciesReference

288877
stoichiometry: 1.0
species: 565595
type: SpeciesReference

560775
constant: false
boundary condition: false
has only substance units: false
initial concentration: 1.80016666666667E-215
initial amount: NaN
in compartment: 560175
type: Species

564235
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 560175
type: Species

287345
stoichiometry: 1.0
species: 564515
type: SpeciesReference

568315
kinetic law: 289471
product: 289459
product: 289446
reactant: 289434
fast: false
reversible: false
type: Reaction

300076
local parameters: 052683
local parameters: 052680
notes: k1*AMPAR_memb_slash_A845_star__B831_star_845_star_*PP1_PSD_slash_PP1_minus_active_PSD-k2*PP1_PSD_slash_PP1_minus_active_PSD_slash_PP1_sbo_13_sbc__slash_PP1_sbo_13_sbc__cplx
type: KineticLaw

573434
kinetic law: 302366
product: 302354
product: 302342
reactant: 302330
fast: false
reversible: false
type: Reaction

565455
constant: true
boundary condition: true
has only substance units: false
initial concentration: 0.08
initial amount: NaN
in compartment: 560175
type: Species

295985
stoichiometry: 1.0
species: 562655
type: SpeciesReference

295042
local parameters: 052353
local parameters: 052350
notes: k1*AMPAR_slash_A_B831_star_*PKA_slash_PKA_minus_active-k2*PKA_slash_PKA_minus_active_slash_PKA_sbo_18_sbc__slash_PKA_sbo_18_sbc__cplx
type: KineticLaw

297923
stoichiometry: 1.0
species: 563635
type: SpeciesReference

290617
stoichiometry: 1.0
species: 561455
type: SpeciesReference

569135
kinetic law: 291500
product: 291488
product: 291476
reactant: 291464
fast: false
reversible: false
type: Reaction

564575
constant: false
boundary condition: false
has only substance units: false
initial concentration: 4.00703703703704E-5
initial amount: NaN
in compartment: 560155
type: Species

299556
stoichiometry: 1.0
species: 565215
type: SpeciesReference

571734
kinetic law: 298236
product: 298224
reactant: 298212
reactant: 298199
notes: Rate is 1/6 of the CaM stim form. We\'ll just reduce all lf k1, k2, k3 so that the Vmax goes down 1/6.
fast: false
reversible: true
type: Reaction

296261
stoichiometry: 1.0
species: 564935
type: SpeciesReference

301659
stoichiometry: 1.0
species: 563755
type: SpeciesReference

301164
stoichiometry: 1.0
species: 565235
type: SpeciesReference

561895
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 560155
type: Species

301369
stoichiometry: 1.0
species: 563755
type: SpeciesReference

573394
kinetic law: 302270
product: 302258
product: 302246
reactant: 302234
fast: false
reversible: false
type: Reaction

301743
stoichiometry: 1.0
species: 565055
type: SpeciesReference

293420
stoichiometry: 1.0
species: 565055
type: SpeciesReference

052723
units: 284709
value: 1.7E-18
type: LocalParameter

567295
kinetic law: 287054
product: 287042
reactant: 287030
fast: false
reversible: true
type: Reaction

287741
stoichiometry: 1.0
species: 560255
type: SpeciesReference

051838
units: 284793
value: 1.08E-19
type: LocalParameter

298734
stoichiometry: 1.0
species: 563835
type: SpeciesReference

288502
local parameters: 051920
notes: k3*CaMKII_slash_actCaMKII_minus_PSD_slash_CaMKII_sbo_4_sbc__slash_CaMKII_sbo_4_sbc__cplx
type: KineticLaw

294038
stoichiometry: 1.0
species: 565255
type: SpeciesReference

298589
stoichiometry: 1.0
species: 560455
type: SpeciesReference

052281
units: 284793
value: 2.011824E-17
type: LocalParameter

289168
stoichiometry: 1.0
species: 565595
type: SpeciesReference

288344
stoichiometry: 1.0
species: 560695
type: SpeciesReference

286560
stoichiometry: 1.0
species: 561255
type: SpeciesReference

299218
stoichiometry: 1.0
species: 563935
type: SpeciesReference

291874
stoichiometry: 1.0
species: 561675
type: SpeciesReference

567255
kinetic law: 286982
product: 286970
reactant: 286958
fast: false
reversible: true
type: Reaction

567835
kinetic law: 288308
product: 288296
product: 288284
reactant: 288272
fast: false
reversible: false
type: Reaction

569134
kinetic law: 291452
product: 291440
reactant: 291428
reactant: 291416
fast: false
reversible: true
type: Reaction

291922
stoichiometry: 1.0
species: 561915
type: SpeciesReference

052610
units: 284709
value: 6.8E-18
type: LocalParameter

297791
stoichiometry: 1.0
species: 562655
type: SpeciesReference

298770
local parameters: 052592
notes: k3*PP1_PSD_slash_PP1_minus_active_PSD_slash_Deph_minus_thr286c_slash_Deph_minus_thr286c_cplx
type: KineticLaw

301969
local parameters: 052824
notes: k3*PP1_PSD_slash_PP1_minus_active_PSD_slash_Deph_minus_thr305a_slash_Deph_minus_thr305a_cplx
type: KineticLaw

052438
units: 284709
value: 2.16E-15
type: LocalParameter

287394
local parameters: 051861
local parameters: 051859
notes: kf*Ca_control_cyt-kb*Ca
type: KineticLaw

297391
stoichiometry: 1.0
species: 565175
type: SpeciesReference

296695
stoichiometry: 1.0
species: 563115
type: SpeciesReference

300475
stoichiometry: 1.0
species: 564195
type: SpeciesReference

051837
units: 284709
value: 0.0
type: LocalParameter

289265
stoichiometry: 1.0
species: 565595
type: SpeciesReference

052722
units: 284709
value: 6.8E-18
type: LocalParameter

295900
stoichiometry: 1.0
species: 562955
type: SpeciesReference

290243
local parameters: 052028
notes: k3*PP1_slash_PP1_minus_active_slash_Deph_minus_thr286_slash_Deph_minus_thr286_cplx
type: KineticLaw

297010
stoichiometry: 1.0
species: 562655
type: SpeciesReference

292055
stoichiometry: 1.0
species: 564915
type: SpeciesReference

295876
stoichiometry: 1.0
species: 564855
type: SpeciesReference

293796
stoichiometry: 1.0
species: 562315
type: SpeciesReference

286328
stoichiometry: 1.0
species: 562575
type: SpeciesReference

285462
stoichiometry: 1.0
species: 561015
type: SpeciesReference

300511
local parameters: 052710
notes: k3*PP1_PSD_slash_PP1_minus_active_PSD_slash_PP1_sbo_17_sbc__slash_PP1_sbo_17_sbc__cplx
type: KineticLaw

567435
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product: 287345
reactant: 287333
fast: false
reversible: true
type: Reaction

299363
stoichiometry: 1.0
species: 565155
type: SpeciesReference

286970
stoichiometry: 1.0
species: 565375
type: SpeciesReference

301890
stoichiometry: 1.0
species: 563755
type: SpeciesReference

285889
stoichiometry: 1.0
species: 561335
type: SpeciesReference

052439
units: 284709
value: 5.4E-16
type: LocalParameter

052017
units: 284793
value: 6.4584E-18
type: LocalParameter

293213
stoichiometry: 1.0
species: 562195
type: SpeciesReference

298650
stoichiometry: 1.0
species: 560515
type: SpeciesReference

289119
stoichiometry: 1.0
species: 560855
type: SpeciesReference

290098
local parameters: 052020
local parameters: 052017
notes: k1*PP1_PSD_slash_PP1_minus_I1_star_*PP1_slash_PP2A-k2*PP1_slash_PP2A_slash_PP2A_minus_dephosph_minus_PP1_minus_I_star__PSD_slash_PP2A_minus_dephosph_minus_PP1_minus_I_star__PSD_cplx
type: KineticLaw

286838
stoichiometry: 1.0
species: 564675
type: SpeciesReference

286378
stoichiometry: 1.0
species: 562655
type: SpeciesReference

296792
stoichiometry: 1.0
species: 563135
type: SpeciesReference

295343
stoichiometry: 1.0
species: 562835
type: SpeciesReference

288272
stoichiometry: 1.0
species: 560675
type: SpeciesReference

291729
stoichiometry: 1.0
species: 561875
type: SpeciesReference

302426
stoichiometry: 1.0
species: 564615
type: SpeciesReference

572574
kinetic law: 300269
product: 300257
reactant: 300245
reactant: 300232
fast: false
reversible: true
type: Reaction

562835
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 560155
type: Species

052337
units: 284793
value: 3.5998992E-16
type: LocalParameter

297301
stoichiometry: 1.0
species: 562655
type: SpeciesReference

564535
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.00538592592592593
initial amount: NaN
in compartment: 560155
type: Species

291175
stoichiometry: 1.0
species: 561755
type: SpeciesReference

301272
stoichiometry: 1.0
species: 563755
type: SpeciesReference

292116
stoichiometry: 1.0
species: 561955
type: SpeciesReference

571414
kinetic law: 297464
product: 297452
reactant: 297440
reactant: 297428
fast: false
reversible: true
type: Reaction

290351
stoichiometry: 1.0
species: 560295
type: SpeciesReference

569554
kinetic law: 292860
product: 292848
product: 292836
reactant: 292824
fast: false
reversible: false
type: Reaction

287454
stoichiometry: 1.0
species: 565475
type: SpeciesReference

290884
stoichiometry: 1.0
species: 561695
type: SpeciesReference

573074
kinetic law: 301478
product: 301466
product: 301454
reactant: 301442
fast: false
reversible: false
type: Reaction

291476
stoichiometry: 1.0
species: 564675
type: SpeciesReference

052650
units: 284709
value: 3.5E-18
type: LocalParameter

570854
kinetic law: 296009
product: 295997
reactant: 295985
reactant: 295973
fast: false
reversible: true
type: Reaction

291825
stoichiometry: 1.0
species: 561895
type: SpeciesReference

565895
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 560175
type: Species

295778
stoichiometry: 1.0
species: 564835
type: SpeciesReference

052500
units: 284793
value: 3.999888E-17
type: LocalParameter

567155
kinetic law: 286765
product: 286753
product: 286741
reactant: 286729
fast: false
reversible: true
type: Reaction

560555
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 560175
type: Species

289434
stoichiometry: 1.0
species: 560915
type: SpeciesReference

298431
local parameters: 052571
local parameters: 052568
notes: k1*CaMKII_slash_CaMKII_minus_thr286_minus_CaM_minus_PSD*PP1_PSD_slash_PP1_minus_active_PSD-k2*PP1_PSD_slash_PP1_minus_active_PSD_slash_Deph_minus_thr286_slash_Deph_minus_thr286_cplx
type: KineticLaw

301068
stoichiometry: 1.0
species: 564975
type: SpeciesReference

051908
units: 284709
value: 2.0E-17
type: LocalParameter

302366
local parameters: 052858
notes: k3*PKC_minus_active_slash_PKC_minus_phosph_minus_neurogranin_PSD_slash_PKC_minus_phosph_minus_neurogranin_PSD_cplx
type: KineticLaw

569854
kinetic law: 293590
product: 293577
reactant: 293565
reactant: 293553
fast: false
reversible: true
type: Reaction

572314
kinetic law: 299640
product: 299628
product: 299616
reactant: 299604
fast: false
reversible: false
type: Reaction

294147
stoichiometry: 1.0
species: 561675
type: SpeciesReference

285670
stoichiometry: 1.0
species: 561115
type: SpeciesReference

285241
stoichiometry: 1.0
species: 560475
type: SpeciesReference

298091
local parameters: 052547
notes: k3*AC_slash_cAMP_minus_PDE_slash_PDE_slash_PDE_cplx
type: KineticLaw

287491
stoichiometry: 1.0
species: 560335
type: SpeciesReference

565815
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 560175
type: Species

569814
kinetic law: 293493
product: 293480
reactant: 293468
reactant: 293456
fast: false
reversible: true
type: Reaction

290279
stoichiometry: 1.0
species: 561495
type: SpeciesReference

572354
kinetic law: 299737
product: 299725
product: 299713
reactant: 299701
fast: false
reversible: false
type: Reaction

566575
kinetic law: 285426
product: 285414
reactant: 285401
reactant: 285388
notes: K3 = 21.5, K4 = 2.8. Assuming that the K4 step happens first, we get kb/kf = 2.8 uM = 1.68e6 so kf =6e-6 assuming kb = 10
fast: false
reversible: true
type: Reaction

051886
units: 284793
value: 2.4E-18
type: LocalParameter

051846
units: 284709
value: 8.0E-20
type: LocalParameter

560895
constant: false
boundary condition: false
has only substance units: false
initial concentration: 2.04433333333333E-215
initial amount: NaN
in compartment: 560175
type: Species

052864
units: 284709
value: 1.26E-16
type: LocalParameter

297706
local parameters: 052523
notes: k3*PKA_slash_PKA_minus_active_slash_PKA_sbo_13_sbc__slash_PKA_sbo_13_sbc__cplx
type: KineticLaw

052433
units: 284709
value: 5.4E-16
type: LocalParameter

560155
constant: true
size: 9.0E-17
spatial dimensions: 3.0
type: Compartment

291356
local parameters: 052106
local parameters: 052103
notes: k1*AMPAR_slash_A845_star__B*PP2B_slash_CaM_Ca_n_minus_CaNAB-k2*PP2B_slash_CaM_Ca_n_minus_CaNAB_slash_PP2B_sbo_17_sbc__slash_PP2B_sbo_17_sbc__cplx
type: KineticLaw

566535
kinetic law: 285328
product: 285316
reactant: 285303
reactant: 285290
notes: Same values as for the main compartment Can the main compartment pool of Ca/CaM be used?
fast: false
reversible: true
type: Reaction

565855
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 560175
type: Species

051909
units: 284709
value: 5.0E-18
type: LocalParameter

301623
local parameters: 052794
local parameters: 052791
notes: k1*AMPAR_memb_slash_A831_star__B831_star_845_star_*PP1_PSD_slash_PP1_minus_active_PSD-k2*PP1_PSD_slash_PP1_minus_active_PSD_slash_PP1_sbo_29_sbc__slash_PP1_sbo_29_sbc__cplx
type: KineticLaw

051998
units: 284793
value: 5.81256E-17
type: LocalParameter

294670
stoichiometry: 1.0
species: 562695
type: SpeciesReference

294706
local parameters: 052327
notes: k3*PKA_slash_PKA_minus_active_slash_PKA_minus_phosph_minus_I1_slash_PKA_minus_phosph_minus_I1_cplx
type: KineticLaw

567115
kinetic law: 286668
product: 286656
product: 286644
reactant: 286632
notes: Let us assume that the equil in this case is very far over to the right. This is probably safe.
fast: false
reversible: true
type: Reaction

288164
local parameters: 051903
local parameters: 051901
notes: k1*AMPAR_memb_slash_A_B845_star_*CaMKII_slash_actCaMKII_minus_PSD-k2*CaMKII_slash_actCaMKII_minus_PSD_slash_CaMKII_sbo_1_sbc__slash_CaMKII_sbo_1_sbc__cplx
type: KineticLaw

300584
stoichiometry: 1.0
species: 565015
type: SpeciesReference

290134
stoichiometry: 1.0
species: 561355
type: SpeciesReference

299592
local parameters: 052649
local parameters: 052646
notes: k1*AMPAR_memb_slash_A831_star_845_star__B845_star_*PP1_PSD_slash_PP1_minus_active_PSD-k2*PP1_PSD_slash_PP1_minus_active_PSD_slash_PP1_sbo_8_sbc__slash_PP1_sbo_8_sbc__cplx
type: KineticLaw

301707
stoichiometry: 1.0
species: 564455
type: SpeciesReference

051778
units: 284793
value: 6.750054E-15
type: LocalParameter

052861
units: 284793
value: 6.11982E-19
type: LocalParameter

051847
units: 284793
value: 1.08E-19
type: LocalParameter

297227
stoichiometry: 1.0
species: 565115
type: SpeciesReference

288913
stoichiometry: 1.0
species: 565595
type: SpeciesReference

571574
kinetic law: 297851
product: 297839
reactant: 297827
reactant: 297815
fast: false
reversible: true
type: Reaction

288998
stoichiometry: 1.0
species: 565115
type: SpeciesReference

563415
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0740740740740741
initial amount: NaN
in compartment: 560155
type: Species

297167
local parameters: 052491
local parameters: 052488
notes: k1*AMPAR_memb_slash_A_B831_star_845_star_*PKA_slash_PKA_minus_active-k2*PKA_slash_PKA_minus_active_slash_PKA_sbo_8_sbc__slash_PKA_sbo_8_sbc__cplx
type: KineticLaw

291777
stoichiometry: 1.0
species: 561675
type: SpeciesReference

300294
stoichiometry: 1.0
species: 565000
type: SpeciesReference

300729
stoichiometry: 1.0
species: 563755
type: SpeciesReference

051906
units: 284793
value: 2.77776E-19
type: LocalParameter

291801
stoichiometry: 1.0
species: 564955
type: SpeciesReference

572394
kinetic law: 299835
product: 299823
product: 299811
reactant: 299799
fast: false
reversible: false
type: Reaction

297694
stoichiometry: 1.0
species: 562655
type: SpeciesReference

566475
kinetic law: 285180
product: 285168
reactant: 285156
fast: false
reversible: true
type: Reaction

571274
kinetic law: 297119
product: 297107
product: 297095
reactant: 297083
fast: false
reversible: false
type: Reaction

294330
stoichiometry: 1.0
species: 565195
type: SpeciesReference

560955
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 560175
type: Species

291440
stoichiometry: 1.0
species: 561815
type: SpeciesReference

052540
units: 284673
value: 299.9976000192
type: LocalParameter

290787
stoichiometry: 1.0
species: 561655
type: SpeciesReference

051888
units: 284709
value: 2.4E-16
type: LocalParameter

293104
local parameters: 052221
local parameters: 052218
notes: k1*AMPAR_memb_slash_A_B845_star_*PP2B_slash_CaM_Ca_n_minus_CaNAB-k2*PP2B_slash_CaM_Ca_n_minus_CaNAB_slash_PP2B_sbo_2_sbc__slash_PP2B_sbo_2_sbc__cplx
type: KineticLaw

565395
constant: true
boundary condition: true
has only substance units: false
initial concentration: 0.011111
initial amount: NaN
in compartment: 560195
type: Species

567195
kinetic law: 286862
product: 286850
product: 286838
reactant: 286826
fast: false
reversible: true
type: Reaction

051777
units: 284709
value: 2.97E-15
type: LocalParameter

300403
stoichiometry: 1.0
species: 563755
type: SpeciesReference

288442
stoichiometry: 1.0
species: 560715
type: SpeciesReference

286874
stoichiometry: 1.0
species: 564975
type: SpeciesReference

563495
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 560155
type: Species

295839
stoichiometry: 1.0
species: 564795
type: SpeciesReference

570354
kinetic law: 294802
product: 294790
product: 294778
reactant: 294766
fast: false
reversible: false
type: Reaction

296382
stoichiometry: 1.0
species: 563055
type: SpeciesReference

052435
units: 284793
value: 3.999888E-17
type: LocalParameter

299158
local parameters: 052618
notes: k3*PP1_PSD_slash_PP1_minus_active_PSD_slash_PP1_sbo_3_sbc__slash_PP1_sbo_3_sbc__cplx
type: KineticLaw

302186
stoichiometry: 1.0
species: 563415
type: SpeciesReference

299737
local parameters: 052656
notes: k3*PP1_PSD_slash_PP1_minus_active_PSD_slash_PP1_sbo_9_sbc__slash_PP1_sbo_9_sbc__cplx
type: KineticLaw

298248
stoichiometry: 1.0
species: 563555
type: SpeciesReference

292152
stoichiometry: 1.0
species: 564735
type: SpeciesReference

301224
stoichiometry: 1.0
species: 564355
type: SpeciesReference

570394
kinetic law: 294898
product: 294886
product: 294874
reactant: 294862
fast: false
reversible: false
type: Reaction

292848
stoichiometry: 1.0
species: 561675
type: SpeciesReference

288719
stoichiometry: 1.0
species: 565595
type: SpeciesReference

566735
kinetic law: 285791
product: 285779
reactant: 285767
reactant: 285755
notes: Use K3 = 21.5 uM here from Stemmer and Klee table 3. kb/kf =21.5 * 6e5 so kf = 7.75e-7, kb = 10
fast: false
reversible: true
type: Reaction

290836
stoichiometry: 1.0
species: 561035
type: SpeciesReference

052541
units: 284709
value: 1.8E-16
type: LocalParameter

052127
units: 284793
value: 1.8106416E-16
type: LocalParameter

293285
stoichiometry: 1.0
species: 562215
type: SpeciesReference

566775
kinetic law: 285877
product: 285864
reactant: 285851
reactant: 285839
notes: K inhib = 1nM from Cohen Ann Rev Bioch 1989, 4 nM from Foukes et al Assume 2 nM. kf /kb = 8.333e-4
fast: false
reversible: true
type: Reaction

297899
local parameters: 052535
notes: k3*PKA_slash_PKA_minus_active_slash_PKA_sbo_15_sbc__slash_PKA_sbo_15_sbc__cplx
type: KineticLaw

052504
units: 284709
value: 5.4E-16
type: LocalParameter

296610
stoichiometry: 1.0
species: 565035
type: SpeciesReference

294742
stoichiometry: 1.0
species: 562715
type: SpeciesReference

573214
kinetic law: 301816
product: 301803
reactant: 301791
reactant: 301779
fast: false
reversible: true
type: Reaction

051841
units: 284793
value: 1.08E-19
type: LocalParameter

052867
units: 284709
value: 3.15E-17
type: LocalParameter

052656
units: 284709
value: 3.5E-18
type: LocalParameter

288128
stoichiometry: 1.0
species: 565095
type: SpeciesReference

052277
units: 284709
value: 7.2E-16
type: LocalParameter

295198
stoichiometry: 1.0
species: 564655
type: SpeciesReference

561735
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 560155
type: Species

299339
stoichiometry: 1.0
species: 563755
type: SpeciesReference

300837
stoichiometry: 1.0
species: 564275
type: SpeciesReference

296719
stoichiometry: 1.0
species: 562655
type: SpeciesReference

297815
stoichiometry: 1.0
species: 565015
type: SpeciesReference

051775
units: 284793
value: 4.86E-15
type: LocalParameter

287681
local parameters: 051878
local parameters: 051876
notes: k1*CaMKII_slash_CaMKII_minus_thr286*CaMKII_slash_tot_autonomous_CaMKII-k2*CaMKII_slash_tot_autonomous_CaMKII_slash_auton_305_slash_auton_305_cplx
type: KineticLaw

562635
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 560155
type: Species

052237
units: 284793
value: 2.011824E-17
type: LocalParameter

296478
stoichiometry: 1.0
species: 563075
type: SpeciesReference

052655
units: 284709
value: 1.4E-17
type: LocalParameter

296105
local parameters: 052420
local parameters: 052417
notes: k1*AMPAR_slash_A831_star_845_star__B*PKA_slash_PKA_minus_active-k2*PKA_slash_PKA_minus_active_slash_PKA_sbo_29_sbc__slash_PKA_sbo_29_sbc__cplx
type: KineticLaw

298055
stoichiometry: 1.0
species: 563475
type: SpeciesReference

286267
local parameters: 051783
local parameters: 051781
notes: kf*AC_slash_cAMP*PKA_slash_R2C2_minus_cAMP3-kb*PKA_slash_R2C2_minus_cAMP4
type: KineticLaw

572614
kinetic law: 300367
product: 300354
reactant: 300342
reactant: 300330
fast: false
reversible: true
type: Reaction

286181
stoichiometry: 1.0
species: 562515
type: SpeciesReference

288056
stoichiometry: 1.0
species: 560635
type: SpeciesReference

296081
stoichiometry: 1.0
species: 562655
type: SpeciesReference

051881
units: 284793
value: 1.2857616E-18
type: LocalParameter

052278
units: 284709
value: 1.8E-16
type: LocalParameter

292547
stoichiometry: 1.0
species: 564695
type: SpeciesReference

052581
units: 284793
value: 2.45142E-17
type: LocalParameter

292667
local parameters: 052190
notes: k3*PP2B_slash_CaM_Ca_n_minus_CaNAB_slash_PP2B_sbo_30_sbc__slash_PP2B_sbo_30_sbc__cplx
type: KineticLaw

289471
local parameters: 051972
notes: k3*CaMKII_slash_actCaMKII_minus_PSD_slash_CaMKII_sbo_14_sbc__slash_CaMKII_sbo_14_sbc__cplx
type: KineticLaw

300245
stoichiometry: 1.0
species: 563755
type: SpeciesReference

051774
units: 284709
value: 2.97E-15
type: LocalParameter

052543
units: 284673
value: 300.001920012288
type: LocalParameter

052658
units: 284793
value: 8.7498E-18
type: LocalParameter

300983
stoichiometry: 1.0
species: 563755
type: SpeciesReference

052274
units: 284793
value: 2.011824E-17
type: LocalParameter

298951
stoichiometry: 1.0
species: 563755
type: SpeciesReference

565315
constant: true
boundary condition: true
has only substance units: false
initial concentration: 2.0
initial amount: NaN
in compartment: 560155
type: Species

569674
kinetic law: 293153
product: 293141
product: 293128
reactant: 293116
fast: false
reversible: false
type: Reaction

051843
units: 284709
value: 8.0E-20
type: LocalParameter

052432
units: 284709
value: 2.16E-15
type: LocalParameter

573134
kinetic law: 301623
product: 301611
reactant: 301599
reactant: 301587
fast: false
reversible: true
type: Reaction

290677
local parameters: 052064
local parameters: 052061
notes: k1*PP1_slash_I1_star_*PP2B_slash_CaNAB_minus_Ca4-k2*PP2B_slash_CaNAB_minus_Ca4_slash_dephosph_inhib1_noCaM_slash_dephosph_inhib1_noCaM_cplx
type: KineticLaw

301320
stoichiometry: 1.0
species: 564375
type: SpeciesReference

293929
local parameters: 052271
notes: k3*PP2B_slash_CaM_Ca_n_minus_CaNAB_slash_PP2B_sbo_10_sbc__slash_PP2B_sbo_10_sbc__cplx
type: KineticLaw

052585
units: 284709
value: 2.5E-17
type: LocalParameter

051884
units: 284709
value: 4.5E-17
type: LocalParameter

296502
stoichiometry: 1.0
species: 563075
type: SpeciesReference

300208
stoichiometry: 1.0
species: 563755
type: SpeciesReference

288828
stoichiometry: 1.0
species: 560795
type: SpeciesReference

289544
stoichiometry: 1.0
species: 565015
type: SpeciesReference

052544
units: 284793
value: 2.2680162E-16
type: LocalParameter

287825
local parameters: 051884
notes: k3*CaMKII_slash_tot_autonomous_CaMKII_slash_auton_286_slash_auton_286_cplx
type: KineticLaw

293700
stoichiometry: 1.0
species: 562295
type: SpeciesReference

285987
stoichiometry: 1.0
species: 561575
type: SpeciesReference

287248
local parameters: 051849
local parameters: 051847
notes: kf*AMPAR_slash_A845_star__B845_star_*AMPAR_memb_slash_Anchor-kb*AMPAR_memb_slash_A845_star__B845_star_
type: KineticLaw

052235
units: 284709
value: 1.8E-16
type: LocalParameter

287175
stoichiometry: 1.0
species: 565295
type: SpeciesReference

293177
stoichiometry: 1.0
species: 561675
type: SpeciesReference

291404
local parameters: 052107
notes: k3*PP2B_slash_CaM_Ca_n_minus_CaNAB_slash_PP2B_sbo_17_sbc__slash_PP2B_sbo_17_sbc__cplx
type: KineticLaw

052503
units: 284709
value: 2.16E-15
type: LocalParameter

289337
stoichiometry: 1.0
species: 560895
type: SpeciesReference

290726
local parameters: 052065
notes: k3*PP2B_slash_CaNAB_minus_Ca4_slash_dephosph_inhib1_noCaM_slash_dephosph_inhib1_noCaM_cplx
type: KineticLaw

295222
stoichiometry: 1.0
species: 562815
type: SpeciesReference

052584
units: 284709
value: 1.0E-16
type: LocalParameter

567335
kinetic law: 287151
product: 287139
reactant: 287127
reactant: 287115
fast: false
reversible: true
type: Reaction

051844
units: 284793
value: 1.08E-19
type: LocalParameter

051883
units: 284709
value: 1.8E-16
type: LocalParameter

293468
stoichiometry: 1.0
species: 561675
type: SpeciesReference

572694
kinetic law: 300560
product: 300548
reactant: 300536
reactant: 300524
fast: false
reversible: true
type: Reaction

573174
kinetic law: 301719
product: 301707
reactant: 301695
reactant: 301683
fast: false
reversible: true
type: Reaction

287236
stoichiometry: 1.0
species: 565135
type: SpeciesReference

572994
kinetic law: 301284
product: 301272
product: 301260
reactant: 301248
fast: false
reversible: false
type: Reaction

051772
units: 284793
value: 4.86E-15
type: LocalParameter

564135
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 560175
type: Species

293893
stoichiometry: 1.0
species: 562335
type: SpeciesReference

568515
kinetic law: 289953
product: 289941
product: 289929
reactant: 289917
fast: false
reversible: false
type: Reaction

285779
stoichiometry: 1.0
species: 561255
type: SpeciesReference

298915
local parameters: 052603
local parameters: 052600
notes: k1*AMPAR_memb_slash_A845_star__B845_star_*PP1_PSD_slash_PP1_minus_active_PSD-k2*PP1_PSD_slash_PP1_minus_active_PSD_slash_PP1_sbo_1_sbc__slash_PP1_sbo_1_sbc__cplx
type: KineticLaw

286157
stoichiometry: 1.0
species: 562515
type: SpeciesReference

287633
local parameters: 051874
notes: k3*CaMKII_slash_tot_CaM_CaMKII_slash_CaM_act_286_slash_CaM_act_286_cplx
type: KineticLaw

560375
constant: false
boundary condition: false
has only substance units: false
initial concentration: 4.90055555555556E-8
initial amount: NaN
in compartment: 560155
type: Species

299085
stoichiometry: 1.0
species: 563755
type: SpeciesReference

572834
kinetic law: 300897
product: 300885
product: 300873
reactant: 300861
fast: false
reversible: false
type: Reaction

563775
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 560175
type: Species

298163
stoichiometry: 1.0
species: 563435
type: SpeciesReference

573474
kinetic law: 302474
product: 302462
product: 302450
product: 302438
reactant: 302426
fast: false
reversible: false
type: Reaction

297428
stoichiometry: 1.0
species: 565000
type: SpeciesReference

052234
units: 284709
value: 7.2E-16
type: LocalParameter

560335
constant: false
boundary condition: false
has only substance units: false
initial concentration: 6.3262962962963E-11
initial amount: NaN
in compartment: 560155
type: Species

290315
stoichiometry: 1.0
species: 560235
type: SpeciesReference

301116
stoichiometry: 1.0
species: 563755
type: SpeciesReference

051901
units: 284793
value: 2.77776E-19
type: LocalParameter

295730
stoichiometry: 1.0
species: 562915
type: SpeciesReference

563735
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 560175
type: Species

052170
units: 284709
value: 1.8E-16
type: LocalParameter

295452
stoichiometry: 1.0
species: 564835
type: SpeciesReference

300136
stoichiometry: 1.0
species: 565175
type: SpeciesReference

289881
stoichiometry: 1.0
species: 561355
type: SpeciesReference

284949
local parameters: 051699
local parameters: 051697
notes: kf*CaMKII_slash_CaMKII_minus_thr286*CaM_slash_CaM_minus_Ca4-kb*CaMKII_slash_CaMKII_minus_thr286_star__minus_CaM
type: KineticLaw

052121
units: 284793
value: 1.8106416E-16
type: LocalParameter

051990
units: 284793
value: 3.07998E-19
type: LocalParameter

299447
local parameters: 052638
notes: k3*PP1_PSD_slash_PP1_minus_active_PSD_slash_PP1_sbo_6_sbc__slash_PP1_sbo_6_sbc__cplx
type: KineticLaw

288381
stoichiometry: 1.0
species: 564995
type: SpeciesReference

290496
stoichiometry: 1.0
species: 561535
type: SpeciesReference

294414
local parameters: 052306
notes: k3*PP2B_slash_CaM_Ca_n_minus_CaNAB_slash_PP2B_sbo_15_sbc__slash_PP2B_sbo_15_sbc__cplx
type: KineticLaw

292776
stoichiometry: 1.0
species: 564815
type: SpeciesReference

295307
stoichiometry: 1.0
species: 562655
type: SpeciesReference

568855
kinetic law: 290775
product: 290763
reactant: 290751
reactant: 290739
notes: The rates here are so slow I do not know if we should even bother with this enz reacn. These numbers are from Liu and Storm. Other refs suggest that the Km stays the same but the Vmax goes to 10% of the CaM stim levels. Prev: k1=2.2e-9, k2 = 0.0052, k3 = 0.0013 New : k1=5.7e-8, k2=.136, k3=.034
fast: false
reversible: true
type: Reaction

286072
local parameters: 051771
local parameters: 051769
notes: kf*CaM_slash_CaM_minus_Ca4*PP2B_slash_CaNAB_minus_Ca4-kb*PP2B_slash_CaM_Ca_n_minus_CaNAB
type: KineticLaw

051951
units: 284709
value: 2.0E-17
type: LocalParameter

296321
stoichiometry: 1.0
species: 564815
type: SpeciesReference

052509
units: 284709
value: 2.16E-15
type: LocalParameter

562295
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 560155
type: Species

051718
units: 284793
value: 4.99998E-16
type: LocalParameter

288610
stoichiometry: 1.0
species: 565035
type: SpeciesReference

569374
kinetic law: 292323
product: 292310
reactant: 292297
reactant: 292285
fast: false
reversible: true
type: Reaction

299110
local parameters: 052617
local parameters: 052614
notes: k1*AMPAR_memb_slash_A_B845_star_*PP1_PSD_slash_PP1_minus_active_PSD-k2*PP1_PSD_slash_PP1_minus_active_PSD_slash_PP1_sbo_3_sbc__slash_PP1_sbo_3_sbc__cplx
type: KineticLaw

289844
stoichiometry: 1.0
species: 561355
type: SpeciesReference

292439
stoichiometry: 1.0
species: 562015
type: SpeciesReference

563835
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 560175
type: Species

052809
units: 284793
value: 8.7498E-18
type: LocalParameter

560695
constant: false
boundary condition: false
has only substance units: false
initial concentration: 1.80016666666667E-215
initial amount: NaN
in compartment: 560175
type: Species

051717
units: 284793
value: 0.0
type: LocalParameter

571994
kinetic law: 298867
product: 298855
product: 298843
reactant: 298830
fast: false
reversible: false
type: Reaction

051952
units: 284709
value: 5.0E-18
type: LocalParameter

052506
units: 284793
value: 3.999888E-17
type: LocalParameter

289229
local parameters: 051961
local parameters: 051959
notes: k1*AMPAR_memb_slash_A831_star_845_star__B845_star_*CaMKII_slash_actCaMKII_minus_PSD-k2*CaMKII_slash_actCaMKII_minus_PSD_slash_CaMKII_sbo_12_sbc__slash_CaMKII_sbo_12_sbc__cplx
type: KineticLaw

564315
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 560175
type: Species

299047
stoichiometry: 1.0
species: 563755
type: SpeciesReference

562375
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 560155
type: Species

296045
stoichiometry: 1.0
species: 562655
type: SpeciesReference

294378
stoichiometry: 1.0
species: 562435
type: SpeciesReference

285034
stoichiometry: 1.0
species: 560495
type: SpeciesReference

051992
units: 284709
value: 2.0E-17
type: LocalParameter

571954
kinetic law: 298770
product: 298758
product: 298746
reactant: 298734
fast: false
reversible: false
type: Reaction

293577
stoichiometry: 1.0
species: 562275
type: SpeciesReference

562995
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 560155
type: Species

564355
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 560175
type: Species

052588
units: 284793
value: 6.2502E-17
type: LocalParameter

568795
kinetic law: 290629
product: 290617
product: 290605
reactant: 290593
fast: false
reversible: false
type: Reaction

568075
kinetic law: 288889
product: 288877
product: 288865
reactant: 288852
fast: false
reversible: false
type: Reaction

301430
local parameters: 052778
local parameters: 052775
notes: k1*AMPAR_memb_slash_A831_star__B831_star_*PP1_PSD_slash_PP1_minus_active_PSD-k2*PP1_PSD_slash_PP1_minus_active_PSD_slash_PP1_sbo_27_sbc__slash_PP1_sbo_27_sbc__cplx
type: KineticLaw

567735
kinetic law: 288068
product: 288056
reactant: 288044
reactant: 288032
fast: false
reversible: true
type: Reaction

051840
units: 284709
value: 8.0E-20
type: LocalParameter

568815
kinetic law: 290677
product: 290665
reactant: 290653
reactant: 290641
notes: The rates here are so slow I do not know if we should even bother with this enz reacn. These numbers are from Liu and Storm. Other refs suggest that the Km stays the same but the Vmax goes to 10% of the CaM stim levels. Prev: k1=2.2e-9, k2 = 0.0052, k3 = 0.0013 New : k1=5.7e-8, k2=.136, k3=.034
fast: false
reversible: true
type: Reaction

567775
kinetic law: 288164
product: 288152
reactant: 288140
reactant: 288128
fast: false
reversible: true
type: Reaction

302474
local parameters: 052867
notes: k3*PKC_minus_active_slash_PKC_minus_phosph_minus_ng_minus_CaM_PSD_slash_PKC_minus_phosph_minus_ng_minus_CaM_PSD_cplx
type: KineticLaw

562935
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 560155
type: Species

294086
stoichiometry: 1.0
species: 562375
type: SpeciesReference

052231
units: 284793
value: 2.011824E-17
type: LocalParameter

565115
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 560175
type: Species

052124
units: 284709
value: 7.2E-16
type: LocalParameter

052058
units: 284709
value: 9.0E-16
type: LocalParameter

289616
local parameters: 051984
local parameters: 051982
notes: k1*CaMKII_slash_CaMKII_minus_thr286_minus_PSD*CaMKII_slash_tot_minus_CaM_minus_CaMKII_minus_PSD-k2*CaMKII_slash_tot_minus_CaM_minus_CaMKII_minus_PSD_slash_CaM_minus_act_minus_305_minus_PSD_slash_CaM_minus_act_minus_305_minus_PSD_cplx
type: KineticLaw

297353
stoichiometry: 1.0
species: 563255
type: SpeciesReference

051995
units: 284709
value: 5.0E-18
type: LocalParameter

298891
stoichiometry: 1.0
species: 563755
type: SpeciesReference

569594
kinetic law: 292959
product: 292947
product: 292935
reactant: 292923
fast: false
reversible: false
type: Reaction

052763
units: 284709
value: 3.5E-18
type: LocalParameter

573034
kinetic law: 301381
product: 301369
product: 301357
reactant: 301344
fast: false
reversible: false
type: Reaction

564075
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 560175
type: Species

288768
stoichiometry: 1.0
species: 565000
type: SpeciesReference

300765
stoichiometry: 1.0
species: 564255
type: SpeciesReference

285132
stoichiometry: 1.0
species: 560555
type: SpeciesReference

051904
units: 284709
value: 5.0E-18
type: LocalParameter

052173
units: 284793
value: 1.8106416E-16
type: LocalParameter

562415
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 560155
type: Species

291248
stoichiometry: 1.0
species: 561775
type: SpeciesReference

561795
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 560155
type: Species

051954
units: 284793
value: 2.77776E-19
type: LocalParameter

295114
stoichiometry: 1.0
species: 562655
type: SpeciesReference

571234
kinetic law: 297022
product: 297010
product: 296998
reactant: 296986
fast: false
reversible: false
type: Reaction

288092
stoichiometry: 1.0
species: 565215
type: SpeciesReference

052125
units: 284709
value: 1.8E-16
type: LocalParameter

562455
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 560155
type: Species

287717
stoichiometry: 1.0
species: 565495
type: SpeciesReference

299194
stoichiometry: 1.0
species: 563935
type: SpeciesReference

296658
stoichiometry: 1.0
species: 562655
type: SpeciesReference

051889
units: 284709
value: 6.0E-17
type: LocalParameter

568575
kinetic law: 290098
product: 290085
reactant: 290073
reactant: 290061
notes: k1 changed from 3.3e-6 to 6.6e-6
fast: false
reversible: true
type: Reaction

052762
units: 284709
value: 1.4E-17
type: LocalParameter

570754
kinetic law: 295766
product: 295754
product: 295742
reactant: 295730
fast: false
reversible: false
type: Reaction

562215
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 560155
type: Species

301176
stoichiometry: 1.0
species: 563755
type: SpeciesReference

298321
stoichiometry: 1.0
species: 563595
type: SpeciesReference

291621
stoichiometry: 1.0
species: 561675
type: SpeciesReference

295391
stoichiometry: 1.0
species: 564875
type: SpeciesReference

301514
stoichiometry: 1.0
species: 564415
type: SpeciesReference

295415
stoichiometry: 1.0
species: 562855
type: SpeciesReference

299848
stoichiometry: 1.0
species: 564995
type: SpeciesReference

299944
stoichiometry: 1.0
species: 565235
type: SpeciesReference

301791
stoichiometry: 1.0
species: 563755
type: SpeciesReference

295622
local parameters: 052390
local parameters: 052387
notes: k1*AMPAR_slash_A_B845_star_*PKA_slash_PKA_minus_active-k2*PKA_slash_PKA_minus_active_slash_PKA_sbo_24_sbc__slash_PKA_sbo_24_sbc__cplx
type: KineticLaw

292691
stoichiometry: 1.0
species: 561675
type: SpeciesReference

297743
stoichiometry: 1.0
species: 563335
type: SpeciesReference

286934
stoichiometry: 1.0
species: 565375
type: SpeciesReference

286765
local parameters: 051816
local parameters: 051814
notes: kf*AMPAR_memb_slash_A831_star__B831_star_-kb*AMPAR_slash_A831_star__B831_star_*AMPAR_memb_slash_Anchor
type: KineticLaw

291597
local parameters: 052119
notes: k3*PP2B_slash_CaM_Ca_n_minus_CaNAB_slash_PP2B_sbo_19_sbc__slash_PP2B_sbo_19_sbc__cplx
type: KineticLaw

301929
stoichiometry: 1.0
species: 564495
type: SpeciesReference

297276
stoichiometry: 1.0
species: 563235
type: SpeciesReference

300028
local parameters: 052677
notes: k3*PP1_PSD_slash_PP1_minus_active_PSD_slash_PP1_sbo_12_sbc__slash_PP1_sbo_12_sbc__cplx
type: KineticLaw

289736
stoichiometry: 1.0
species: 560555
type: SpeciesReference

052176
units: 284709
value: 7.2E-16
type: LocalParameter

302030
stoichiometry: 1.0
species: 564535
type: SpeciesReference

564875
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 560155
type: Species

051956
units: 284709
value: 2.0E-17
type: LocalParameter

570574
kinetic law: 295331
product: 295319
reactant: 295307
reactant: 295295
fast: false
reversible: true
type: Reaction

285622
stoichiometry: 1.0
species: 561215
type: SpeciesReference

286668
local parameters: 051810
local parameters: 051808
notes: kf*PP1_PSD_slash_PP1_minus_I1-kb*PP1_PSD_slash_I1*PP1_PSD_slash_PP1_minus_active_PSD
type: KineticLaw

052806
units: 284709
value: 3.5E-18
type: LocalParameter

570814
kinetic law: 295912
product: 295900
reactant: 295888
reactant: 295876
fast: false
reversible: true
type: Reaction

052059
units: 284709
value: 2.25E-16
type: LocalParameter

572014
kinetic law: 298915
product: 298903
reactant: 298891
reactant: 298879
fast: false
reversible: true
type: Reaction

288598
local parameters: 051925
notes: k3*CaMKII_slash_actCaMKII_minus_PSD_slash_CaMKII_sbo_5_sbc__slash_CaMKII_sbo_5_sbc__cplx
type: KineticLaw

295790
stoichiometry: 1.0
species: 562655
type: SpeciesReference

051903
units: 284709
value: 2.0E-17
type: LocalParameter

298999
stoichiometry: 1.0
species: 563895
type: SpeciesReference

297464
local parameters: 052509
local parameters: 052506
notes: k1*AMPAR_memb_slash_A_B831_star_*PKA_slash_PKA_minus_active-k2*PKA_slash_PKA_minus_active_slash_PKA_sbo_11_sbc__slash_PKA_sbo_11_sbc__cplx
type: KineticLaw

292043
stoichiometry: 1.0
species: 561935
type: SpeciesReference

298139
local parameters: 052552
local parameters: 052549
notes: k1*AC_slash_cAMP*AC_slash_cAMP_minus_PDE_star_-k2*AC_slash_cAMP_minus_PDE_star__slash_PDE_star__slash_PDE_star__cplx
type: KineticLaw

294488
stoichiometry: 1.0
species: 561115
type: SpeciesReference

300184
stoichiometry: 1.0
species: 564135
type: SpeciesReference

299291
stoichiometry: 1.0
species: 563955
type: SpeciesReference

564395
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 560175
type: Species

294524
stoichiometry: 1.0
species: 563455
type: SpeciesReference

052177
units: 284709
value: 1.8E-16
type: LocalParameter

560615
constant: false
boundary condition: false
has only substance units: false
initial concentration: 2.0
initial amount: NaN
in compartment: 560175
type: Species

297119
local parameters: 052485
notes: k3*PKA_slash_PKA_minus_active_slash_PKA_sbo_7_sbc__slash_PKA_sbo_7_sbc__cplx
type: KineticLaw

051957
units: 284709
value: 5.0E-18
type: LocalParameter

570174
kinetic law: 294366
product: 294354
reactant: 294342
reactant: 294330
fast: false
reversible: true
type: Reaction

296430
stoichiometry: 1.0
species: 562655
type: SpeciesReference

565355
notes: ATP is present in all cells between 2 and 10 mM. See Lehninger
constant: true
boundary condition: true
has only substance units: false
initial concentration: 2000.0
initial amount: NaN
in compartment: 560155
type: Species

284913
stoichiometry: 1.0
species: 560315
type: SpeciesReference

052025
units: 284709
value: 9.0E-16
type: LocalParameter

561415
constant: false
boundary condition: false
has only substance units: false
initial concentration: 2.21555555555556E-7
initial amount: NaN
in compartment: 560155
type: Species

286620
local parameters: 051807
local parameters: 051805
notes: kf*AC_slash_cAMP-kb*AC_slash_cAMP_in_dend
type: KineticLaw

300657
local parameters: 052722
local parameters: 052719
notes: k1*AMPAR_memb_slash_A831_star_845_star__B831_star_*PP1_PSD_slash_PP1_minus_active_PSD-k2*PP1_PSD_slash_PP1_minus_active_PSD_slash_PP1_sbo_19_sbc__slash_PP1_sbo_19_sbc__cplx
type: KineticLaw

052737
units: 284709
value: 3.5E-18
type: LocalParameter

286499
local parameters: 051798
local parameters: 051796
notes: kf*AC_slash_AC2_star_-kb*AC_slash_AC2
type: KineticLaw

051732
units: 284709
value: 9.0E-17
type: LocalParameter

051937
units: 284793
value: 2.77776E-19
type: LocalParameter

052408
units: 284709
value: 2.16E-15
type: LocalParameter

052079
units: 284793
value: 3.0779838E-17
type: LocalParameter

294584
stoichiometry: 1.0
species: 563495
type: SpeciesReference

294946
local parameters: 052347
local parameters: 052344
notes: k1*AMPAR_slash_A831_star__B*PKA_slash_PKA_minus_active-k2*PKA_slash_PKA_minus_active_slash_PKA_sbo_16_sbc__slash_PKA_sbo_16_sbc__cplx
type: KineticLaw

570514
kinetic law: 295186
product: 295174
product: 295162
reactant: 295150
fast: false
reversible: false
type: Reaction

561495
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 560155
type: Species

051733
units: 284709
value: 4.5E-19
type: LocalParameter

565755
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 560175
type: Species

567515
kinetic law: 287530
product: 287517
product: 287504
reactant: 287491
fast: false
reversible: false
type: Reaction

052736
units: 284709
value: 1.4E-17
type: LocalParameter

289046
stoichiometry: 1.0
species: 560835
type: SpeciesReference

570554
kinetic law: 295283
product: 295270
product: 295258
reactant: 295246
fast: false
reversible: false
type: Reaction

290532
local parameters: 052052
notes: k3*PP1_slash_PP1_minus_active_slash_Deph_minus_thr286c_slash_Deph_minus_thr286c_cplx
type: KineticLaw

302306
stoichiometry: 1.0
species: 564595
type: SpeciesReference

291693
local parameters: 052125
notes: k3*PP2B_slash_CaM_Ca_n_minus_CaNAB_slash_PP2B_sbo_20_sbc__slash_PP2B_sbo_20_sbc__cplx
type: KineticLaw

297586
stoichiometry: 1.0
species: 565255
type: SpeciesReference

294572
stoichiometry: 1.0
species: 562675
type: SpeciesReference

562155
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 560155
type: Species

294645
stoichiometry: 1.0
species: 562695
type: SpeciesReference

285547
stoichiometry: 1.0
species: 561235
type: SpeciesReference

298309
stoichiometry: 1.0
species: 563575
type: SpeciesReference

293676
stoichiometry: 1.0
species: 562295
type: SpeciesReference

299676
stoichiometry: 1.0
species: 564035
type: SpeciesReference

287971
local parameters: 051893
local parameters: 051891
notes: k1*CaMKII_slash_CaMKII_minus_CaM_minus_PSD*CaMKII_slash_tot_minus_auto_minus_PSD-k2*CaMKII_slash_tot_minus_auto_minus_PSD_slash_auton_minus_286_minus_PSD_slash_auton_minus_286_minus_PSD_cplx
type: KineticLaw

285364
stoichiometry: 1.0
species: 561155
type: SpeciesReference

291054
stoichiometry: 1.0
species: 561735
type: SpeciesReference

296490
local parameters: 052444
local parameters: 052441
notes: k1*AMPAR_memb_slash_A845_star__B*PKA_slash_PKA_minus_active-k2*PKA_slash_PKA_minus_active_slash_PKA_sbo_1_sbc__slash_PKA_sbo_1_sbc__cplx
type: KineticLaw

299243
stoichiometry: 1.0
species: 563755
type: SpeciesReference

288008
stoichiometry: 1.0
species: 565555
type: SpeciesReference

052179
units: 284793
value: 1.8106416E-16
type: LocalParameter

052739
units: 284793
value: 8.7498E-18
type: LocalParameter

571394
kinetic law: 297416
product: 297404
product: 297391
reactant: 297379
fast: false
reversible: false
type: Reaction

570734
kinetic law: 295718
product: 295706
reactant: 295694
reactant: 295682
fast: false
reversible: true
type: Reaction

298879
stoichiometry: 1.0
species: 565135
type: SpeciesReference

051935
units: 284709
value: 5.0E-18
type: LocalParameter

300693
stoichiometry: 1.0
species: 563755
type: SpeciesReference

290025
stoichiometry: 1.0
species: 563675
type: SpeciesReference

299011
local parameters: 052610
local parameters: 052607
notes: k1*AMPAR_memb_slash_A845_star__B*PP1_PSD_slash_PP1_minus_active_PSD-k2*PP1_PSD_slash_PP1_minus_active_PSD_slash_PP1_sbo_2_sbc__slash_PP1_sbo_2_sbc__cplx
type: KineticLaw

052076
units: 284709
value: 2.403E-16
type: LocalParameter

298686
stoichiometry: 1.0
species: 560455
type: SpeciesReference

052778
units: 284709
value: 1.4E-17
type: LocalParameter

052077
units: 284709
value: 6.03E-17
type: LocalParameter

286024
local parameters: 051768
local parameters: 051766
notes: kf*PP2B_slash_CaNAB*Ca^2-kb*PP2B_slash_CaNAB_minus_Ca2
type: KineticLaw

287078
stoichiometry: 1.0
species: 565295
type: SpeciesReference

287861
stoichiometry: 1.0
species: 560575
type: SpeciesReference

568135
kinetic law: 289034
product: 289022
reactant: 289010
reactant: 288998
fast: false
reversible: true
type: Reaction

287934
stoichiometry: 1.0
species: 560535
type: SpeciesReference

302270
local parameters: 052851
notes: k3*PKC_minus_active_slash_phosph_minus_AC2_slash_phosph_minus_AC2_cplx
type: KineticLaw

296550
stoichiometry: 1.0
species: 564975
type: SpeciesReference

567915
kinetic law: 288502
product: 288490
product: 288478
reactant: 288466
fast: false
reversible: false
type: Reaction

295500
stoichiometry: 1.0
species: 562655
type: SpeciesReference

289688
stoichiometry: 1.0
species: 565615
type: SpeciesReference

292607
stoichiometry: 1.0
species: 562055
type: SpeciesReference

051735
units: 284709
value: 0.0
type: LocalParameter

052028
units: 284709
value: 2.25E-16
type: LocalParameter

288646
local parameters: 051929
local parameters: 051927
notes: k1*AMPAR_memb_slash_A845_star__B*CaMKII_slash_actCaMKII_minus_PSD-k2*CaMKII_slash_actCaMKII_minus_PSD_slash_CaMKII_sbo_6_sbc__slash_CaMKII_sbo_6_sbc__cplx
type: KineticLaw

051934
units: 284709
value: 2.0E-17
type: LocalParameter

297634
stoichiometry: 1.0
species: 562655
type: SpeciesReference

300330
stoichiometry: 1.0
species: 565255
type: SpeciesReference

289386
stoichiometry: 1.0
species: 565055
type: SpeciesReference

052779
units: 284709
value: 3.5E-18
type: LocalParameter

291500
local parameters: 052113
notes: k3*PP2B_slash_CaM_Ca_n_minus_CaNAB_slash_PP2B_sbo_18_sbc__slash_PP2B_sbo_18_sbc__cplx
type: KineticLaw

052827
units: 284793
value: 9.180054E-18
type: LocalParameter

052405
units: 284793
value: 3.5998992E-16
type: LocalParameter

295536
stoichiometry: 1.0
species: 562875
type: SpeciesReference

566835
kinetic law: 286024
product: 286012
reactant: 285999
reactant: 285987
notes: going on the experience with CaM, we put the fast (high affinity) sites first. We only know (Stemmer and Klee) that the affinity is < 70 nM. Assuming 10 nM at first, we get kf = 2.78e-8, kb = 1. Try 20 nM. kf = 7e-9, kb = 1.
fast: false
reversible: true
type: Reaction

573374
kinetic law: 302222
product: 302210
reactant: 302198
reactant: 302186
notes: Phorbol esters have little effect on AC1 or on the Gs-stimulation of AC2. So in this model we are only dealing with the increase in basal activation of AC2 induced by PKC k1 = 1.66e-6 k2 = 16 k3 =4
fast: false
reversible: true
type: Reaction

288490
stoichiometry: 1.0
species: 565595
type: SpeciesReference

565635
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 560175
type: Species

292860
local parameters: 052203
notes: k3*PP2B_slash_CaM_Ca_n_minus_CaNAB_slash_PP2B_sbo_32_sbc__slash_PP2B_sbo_32_sbc__cplx
type: KineticLaw

290387
local parameters: 052041
local parameters: 052039
notes: k1*CaMKII_slash_CaMKII_star__star__star_*PP1_slash_PP1_minus_active-k2*PP1_slash_PP1_minus_active_slash_Deph_minus_thr305_slash_Deph_minus_thr305_cplx
type: KineticLaw

298358
stoichiometry: 1.0
species: 563435
type: SpeciesReference

292487
stoichiometry: 1.0
species: 564755
type: SpeciesReference

051736
units: 284745
value: 7.2E-16
type: LocalParameter

301828
stoichiometry: 1.0
species: 564475
type: SpeciesReference

292362
stoichiometry: 1.0
species: 561675
type: SpeciesReference

296165
stoichiometry: 1.0
species: 564895
type: SpeciesReference

296853
stoichiometry: 1.0
species: 562655
type: SpeciesReference

052020
units: 284709
value: 7.50006E-16
type: LocalParameter

568975
kinetic law: 291066
product: 291054
reactant: 291042
reactant: 291030
fast: false
reversible: true
type: Reaction

571514
kinetic law: 297706
product: 297694
product: 297682
reactant: 297670
fast: false
reversible: false
type: Reaction

297191
stoichiometry: 1.0
species: 565235
type: SpeciesReference

568935
kinetic law: 290968
product: 290956
reactant: 290944
reactant: 290932
fast: false
reversible: true
type: Reaction

052627
units: 284793
value: 8.7498E-18
type: LocalParameter

285204
stoichiometry: 1.0
species: 561195
type: SpeciesReference

291657
stoichiometry: 1.0
species: 561855
type: SpeciesReference

285938
stoichiometry: 2.0
species: 560215
type: SpeciesReference

564175
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 560175
type: Species

299399
local parameters: 052637
local parameters: 052634
notes: k1*AMPAR_memb_slash_A831_star__B845_star_*PP1_PSD_slash_PP1_minus_active_PSD-k2*PP1_PSD_slash_PP1_minus_active_PSD_slash_PP1_sbo_6_sbc__slash_PP1_sbo_6_sbc__cplx
type: KineticLaw

297046
stoichiometry: 1.0
species: 562655
type: SpeciesReference

568295
kinetic law: 289422
product: 289410
reactant: 289398
reactant: 289386
fast: false
reversible: true
type: Reaction

295682
stoichiometry: 1.0
species: 564955
type: SpeciesReference

294982
stoichiometry: 1.0
species: 562655
type: SpeciesReference

301599
stoichiometry: 1.0
species: 563755
type: SpeciesReference

052821
units: 284709
value: 1.0E-16
type: LocalParameter

052021
units: 284709
value: 1.8E-16
type: LocalParameter

572234
kinetic law: 299447
product: 299435
product: 299423
reactant: 299411
fast: false
reversible: false
type: Reaction

290968
local parameters: 052082
local parameters: 052079
notes: k1*PP1_slash_I1_star_*PP2B_slash_CaM_Ca_n_minus_CaNAB-k2*PP2B_slash_CaM_Ca_n_minus_CaNAB_slash_dephosph_inhib1_slash_dephosph_inhib1_cplx
type: KineticLaw

052403
units: 284709
value: 5.4E-16
type: LocalParameter

290424
stoichiometry: 1.0
species: 561455
type: SpeciesReference

285414
stoichiometry: 1.0
species: 561175
type: SpeciesReference

561335
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 560155
type: Species

300548
stoichiometry: 1.0
species: 564215
type: SpeciesReference

294269
local parameters: 052298
local parameters: 052295
notes: k1*AMPAR_memb_slash_A831_star_845_star__B831_star_*PP2B_slash_CaM_Ca_n_minus_CaNAB-k2*PP2B_slash_CaM_Ca_n_minus_CaNAB_slash_PP2B_sbo_14_sbc__slash_PP2B_sbo_14_sbc__cplx
type: KineticLaw

568215
kinetic law: 289229
product: 289217
reactant: 289205
reactant: 289192
fast: false
reversible: true
type: Reaction

052140
units: 284793
value: 1.8106416E-16
type: LocalParameter

284998
local parameters: 051702
local parameters: 051700
notes: kf*CaMKII_slash_CaMKII_minus_thr305_minus_PSD-kb*CaMKII_slash_CaMK_minus_thr305*CaMKII_slash_NMDAR
type: KineticLaw

289796
stoichiometry: 1.0
species: 561375
type: SpeciesReference

296804
stoichiometry: 1.0
species: 565215
type: SpeciesReference

285658
local parameters: 051744
local parameters: 051742
notes: kf*CaM_slash_CaM_minus_Ca3_minus_PSD*Ca_minus_PSD-kb*CaM_slash_CaM_minus_Ca4_minus_PSD
type: KineticLaw

561015
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 560155
type: Species

563995
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 560175
type: Species

051738
units: 284709
value: 7.2E-16
type: LocalParameter

291380
stoichiometry: 1.0
species: 564655
type: SpeciesReference

052023
units: 284793
value: 2.2062942E-16
type: LocalParameter

572194
kinetic law: 299351
product: 299339
product: 299327
reactant: 299315
fast: false
reversible: false
type: Reaction

569235
kinetic law: 291789
product: 291777
product: 291765
reactant: 291753
fast: false
reversible: false
type: Reaction

560595
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 560175
type: Species

561095
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 560175
type: Species

052402
units: 284709
value: 2.16E-15
type: LocalParameter

569974
kinetic law: 293881
product: 293869
reactant: 293857
reactant: 293844
fast: false
reversible: true
type: Reaction

297525
stoichiometry: 1.0
species: 565195
type: SpeciesReference

052824
units: 284709
value: 2.5E-17
type: LocalParameter

051939
units: 284709
value: 2.0E-17
type: LocalParameter

566355
kinetic law: 284901
product: 284889
reactant: 284877
reactant: 284865
notes: This is tricky. There is some cooperativity here arising from interactions between the subunits of the CAMKII holoenzyme. However, the stoichiometry is 1. Kb/Kf = 6e4 #/cell. Rate is fast (see Hanson et al Neuron 12 943-956 1994) so lets say kb = 10. This gives kf = 1.6667e-4 H&S AnnRev Biochem 92 give tau for dissoc as 0.2 sec at low Ca, 0.4 at high. Low Ca = 100 nM = physiol.
fast: false
reversible: true
type: Reaction

566395
kinetic law: 284998
product: 284986
product: 284973
reactant: 284961
notes: Same as for back_1
fast: false
reversible: true
type: Reaction

289953
local parameters: 052009
notes: k3*PP1_slash_PP2A_slash_PP2A_minus_dephosph_minus_PP1_minus_I_star__slash_PP2A_minus_dephosph_minus_PP1_minus_I_star__cplx
type: KineticLaw

052073
units: 284793
value: 3.0024108E-17
type: LocalParameter

295573
local parameters: 052385
notes: k3*PKA_slash_PKA_minus_active_slash_PKA_sbo_23_sbc__slash_PKA_sbo_23_sbc__cplx
type: KineticLaw

291018
local parameters: 052083
notes: k3*PP2B_slash_CaM_Ca_n_minus_CaNAB_slash_dephosph_inhib1_slash_dephosph_inhib1_cplx
type: KineticLaw

052340
units: 284709
value: 2.16E-15
type: LocalParameter

288682
stoichiometry: 1.0
species: 565595
type: SpeciesReference

288950
stoichiometry: 1.0
species: 560815
type: SpeciesReference

051739
units: 284793
value: 3.6E-17
type: LocalParameter

293966
stoichiometry: 1.0
species: 562355
type: SpeciesReference

299774
stoichiometry: 1.0
species: 564055
type: SpeciesReference

299628
stoichiometry: 1.0
species: 563755
type: SpeciesReference

294306
stoichiometry: 1.0
species: 561675
type: SpeciesReference

572654
kinetic law: 300463
product: 300451
reactant: 300439
reactant: 300427
fast: false
reversible: true
type: Reaction

296213
stoichiometry: 1.0
species: 563015
type: SpeciesReference

286596
stoichiometry: 1.0
species: 563635
type: SpeciesReference

288538
stoichiometry: 1.0
species: 560735
type: SpeciesReference

568255
kinetic law: 289325
product: 289313
reactant: 289301
reactant: 289289
fast: false
reversible: true
type: Reaction

052341
units: 284709
value: 5.4E-16
type: LocalParameter

571634
kinetic law: 297995
modifier: 297983
product: 297971
reactant: 297959
notes: Reduced Km to match expt data for basal activation of AC2 by PKC. Now k1 = 2.9e-6, k2 = 72, k3 = 18 18 Feb: Raised Km to 300 based on BRENDA data. Unlikely to make much difference, given the vast amount of ATP.
fast: false
reversible: false
type: Reaction

302066
local parameters: 052833
notes: k3*PKC_minus_active_slash_PKC_minus_phosph_minus_neurogranin_slash_PKC_minus_phosph_minus_neurogranin_cplx
type: KineticLaw

292323
local parameters: 052169
local parameters: 052166
notes: k1*AMPAR_slash_A845_star__B831_star_845_star_*PP2B_slash_CaM_Ca_n_minus_CaNAB-k2*PP2B_slash_CaM_Ca_n_minus_CaNAB_slash_PP2B_sbo_27_sbc__slash_PP2B_sbo_27_sbc__cplx
type: KineticLaw

560715
constant: false
boundary condition: false
has only substance units: false
initial concentration: 7.1375E-215
initial amount: NaN
in compartment: 560175
type: Species

285303
stoichiometry: 1.0
species: 561195
type: SpeciesReference

567395
kinetic law: 287285
product: 287273
reactant: 287260
notes: Represents both synthesis and degradation of the receptor. The rate is set to be rather fast for now. The forward rate also includes scaling terms because the AMPAR_bulk is in the dendritic volume of 5e-18. This means that we need to lower Kf to account for the difference in volumes. Effectively Kf is 1/sec, but the scaled version becomes 9e-20/5e-18 = 0.018
fast: false
reversible: true
type: Reaction

052320
units: 284709
value: 8.1E-16
type: LocalParameter

570494
kinetic law: 295138
product: 295126
reactant: 295114
reactant: 295102
fast: false
reversible: true
type: Reaction

287333
stoichiometry: 1.0
species: 565415
type: SpeciesReference

298830
stoichiometry: 1.0
species: 563855
type: SpeciesReference

572974
kinetic law: 301236
product: 301224
reactant: 301212
reactant: 301200
fast: false
reversible: true
type: Reaction

052623
units: 284709
value: 6.8E-18
type: LocalParameter

572454
kinetic law: 299980
product: 299968
reactant: 299956
reactant: 299944
fast: false
reversible: true
type: Reaction

284733
exponent: -1.0
scale: 0
multipler: 1.0
kind: SECOND
type: SBMLUnit

571794
kinetic law: 298382
product: 298370
product: 298358
reactant: 298345
fast: false
reversible: false
type: Reaction

292715
local parameters: 052196
local parameters: 052193
notes: k1*AMPAR_slash_A845_star__B831_star_845_star_*PP2B_slash_CaM_Ca_n_minus_CaNAB-k2*PP2B_slash_CaM_Ca_n_minus_CaNAB_slash_PP2B_sbo_31_sbc__slash_PP2B_sbo_31_sbc__cplx
type: KineticLaw

294874
stoichiometry: 1.0
species: 564695
type: SpeciesReference

296744
stoichiometry: 1.0
species: 565155
type: SpeciesReference

052387
units: 284793
value: 3.5998992E-16
type: LocalParameter

052665
units: 284793
value: 8.7498E-18
type: LocalParameter

572174
kinetic law: 299303
product: 299291
reactant: 299279
reactant: 299267
fast: false
reversible: true
type: Reaction

294110
stoichiometry: 1.0
species: 561675
type: SpeciesReference

052070
units: 284709
value: 1.224E-17
type: LocalParameter

052295
units: 284793
value: 2.011824E-17
type: LocalParameter

564815
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 560155
type: Species

562795
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 560155
type: Species

300885
stoichiometry: 1.0
species: 563755
type: SpeciesReference

293056
local parameters: 052216
notes: k3*PP2B_slash_CaM_Ca_n_minus_CaNAB_slash_PP2B_sbo_1_sbc__slash_PP2B_sbo_1_sbc__cplx
type: KineticLaw

572494
kinetic law: 300076
product: 300064
reactant: 300052
reactant: 300040
fast: false
reversible: true
type: Reaction

293334
stoichiometry: 1.0
species: 561675
type: SpeciesReference

292212
stoichiometry: 1.0
species: 561975
type: SpeciesReference

289905
local parameters: 052008
local parameters: 052006
notes: k1*PP1_slash_PP1_minus_I1_star_*PP1_slash_PP2A-k2*PP1_slash_PP2A_slash_PP2A_minus_dephosph_minus_PP1_minus_I_star__slash_PP2A_minus_dephosph_minus_PP1_minus_I_star__cplx
type: KineticLaw

052624
units: 284709
value: 1.7E-18
type: LocalParameter

286801
stoichiometry: 1.0
species: 565295
type: SpeciesReference

290605
stoichiometry: 1.0
species: 560235
type: SpeciesReference

295802
stoichiometry: 1.0
species: 562935
type: SpeciesReference

568755
kinetic law: 290532
product: 290520
product: 290508
reactant: 290496
fast: false
reversible: false
type: Reaction

564855
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 560155
type: Species

052347
units: 284709
value: 2.16E-15
type: LocalParameter

292923
stoichiometry: 1.0
species: 562135
type: SpeciesReference

295997
stoichiometry: 1.0
species: 562975
type: SpeciesReference

295054
stoichiometry: 1.0
species: 562775
type: SpeciesReference

570134
kinetic law: 294269
product: 294257
reactant: 294245
reactant: 294233
fast: false
reversible: true
type: Reaction

288865
stoichiometry: 1.0
species: 565255
type: SpeciesReference

572414
kinetic law: 299884
product: 299872
reactant: 299860
reactant: 299848
fast: false
reversible: true
type: Reaction

296406
stoichiometry: 1.0
species: 563055
type: SpeciesReference

052071
units: 284709
value: 3.06E-18
type: LocalParameter

298468
stoichiometry: 1.0
species: 563755
type: SpeciesReference

300064
stoichiometry: 1.0
species: 564115
type: SpeciesReference

293748
stoichiometry: 1.0
species: 565235
type: SpeciesReference

052384
units: 284709
value: 2.16E-15
type: LocalParameter

287297
stoichiometry: 1.0
species: 565275
type: SpeciesReference

292812
local parameters: 052202
local parameters: 052199
notes: k1*AMPAR_slash_A835_star_845_star__B835_star_845_star_*PP2B_slash_CaM_Ca_n_minus_CaNAB-k2*PP2B_slash_CaM_Ca_n_minus_CaNAB_slash_PP2B_sbo_32_sbc__slash_PP2B_sbo_32_sbc__cplx
type: KineticLaw

296598
stoichiometry: 1.0
species: 563095
type: SpeciesReference

052559
units: 284709
value: 1.5003E-16
type: LocalParameter

052298
units: 284709
value: 7.2E-16
type: LocalParameter

291609
stoichiometry: 1.0
species: 564935
type: SpeciesReference

291272
stoichiometry: 1.0
species: 561775
type: SpeciesReference

561955
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 560155
type: Species

052344
units: 284793
value: 3.5998992E-16
type: LocalParameter

570454
kinetic law: 295042
product: 295030
reactant: 295018
reactant: 295006
fast: false
reversible: true
type: Reaction

288224
stoichiometry: 1.0
species: 565035
type: SpeciesReference

052497
units: 284709
value: 2.16E-15
type: LocalParameter

563355
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 560155
type: Species

297863
stoichiometry: 1.0
species: 563355
type: SpeciesReference

565675
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 560155
type: Species

302234
stoichiometry: 1.0
species: 564575
type: SpeciesReference

563295
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 560155
type: Species

561275
constant: false
boundary condition: false
has only substance units: false
initial concentration: 1.8
initial amount: NaN
in compartment: 560155
type: Species

291995
stoichiometry: 1.0
species: 564855
type: SpeciesReference

568555
kinetic law: 290049
product: 290037
product: 290025
reactant: 290013
fast: false
reversible: false
type: Reaction

300958
stoichiometry: 1.0
species: 564295
type: SpeciesReference

564015
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 560175
type: Species

300921
stoichiometry: 1.0
species: 563755
type: SpeciesReference

569175
kinetic law: 291645
product: 291633
reactant: 291621
reactant: 291609
fast: false
reversible: true
type: Reaction

298601
stoichiometry: 1.0
species: 563755
type: SpeciesReference

052385
units: 284709
value: 5.4E-16
type: LocalParameter

296913
stoichiometry: 1.0
species: 562655
type: SpeciesReference

287543
stoichiometry: 1.0
species: 560255
type: SpeciesReference

563255
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 560155
type: Species

052323
units: 284793
value: 5.399946E-16
type: LocalParameter

561755
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 560155
type: Species

051829
units: 284709
value: 3.24E-21
type: LocalParameter

052558
units: 284709
value: 6.003E-16
type: LocalParameter

300379
stoichiometry: 1.0
species: 564175
type: SpeciesReference

293372
stoichiometry: 1.0
species: 561675
type: SpeciesReference

052498
units: 284709
value: 5.4E-16
type: LocalParameter

295150
stoichiometry: 1.0
species: 562795
type: SpeciesReference

291127
stoichiometry: 1.0
species: 563695
type: SpeciesReference

293857
stoichiometry: 1.0
species: 561675
type: SpeciesReference

299519
stoichiometry: 1.0
species: 564995
type: SpeciesReference

289640
stoichiometry: 1.0
species: 560455
type: SpeciesReference

052730
units: 284709
value: 3.5E-18
type: LocalParameter

051693
units: 284793
value: 4.4999712E-15
type: LocalParameter

292595
stoichiometry: 1.0
species: 561675
type: SpeciesReference

301864
local parameters: 052815
notes: k3*PP1_PSD_slash_PP1_minus_active_PSD_slash_PP1_sbo_31_sbc__slash_PP1_sbo_31_sbc__cplx
type: KineticLaw

564635
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0925925925925926
initial amount: NaN
in compartment: 560155
type: Species

299351
local parameters: 052631
notes: k3*PP1_PSD_slash_PP1_minus_active_PSD_slash_PP1_sbo_5_sbc__slash_PP1_sbo_5_sbc__cplx
type: KineticLaw

285474
local parameters: 051732
local parameters: 051730
notes: kf*CaM_slash_neurogranin*CaM_slash_CaM-kb*CaM_slash_neurogranin_minus_CaM
type: KineticLaw

296009
local parameters: 052414
local parameters: 052411
notes: k1*AMPAR_slash_A845_star__B*PKA_slash_PKA_minus_active-k2*PKA_slash_PKA_minus_active_slash_PKA_sbo_28_sbc__slash_PKA_sbo_28_sbc__cplx
type: KineticLaw

293784
local parameters: 052264
local parameters: 052261
notes: k1*AMPAR_memb_slash_A845_star__B831_star_845_star_*PP2B_slash_CaM_Ca_n_minus_CaNAB-k2*PP2B_slash_CaM_Ca_n_minus_CaNAB_slash_PP2B_sbo_9_sbc__slash_PP2B_sbo_9_sbc__cplx
type: KineticLaw

295888
stoichiometry: 1.0
species: 562655
type: SpeciesReference

292067
stoichiometry: 1.0
species: 561675
type: SpeciesReference

052733
units: 284793
value: 8.7498E-18
type: LocalParameter

052291
units: 284709
value: 7.2E-16
type: LocalParameter

296780
local parameters: 052463
local parameters: 052460
notes: k1*AMPAR_memb_slash_A831_star__B845_star_*PKA_slash_PKA_minus_active-k2*PKA_slash_PKA_minus_active_slash_PKA_sbo_4_sbc__slash_PKA_sbo_4_sbc__cplx
type: KineticLaw

295355
stoichiometry: 1.0
species: 564955
type: SpeciesReference

301551
stoichiometry: 1.0
species: 565215
type: SpeciesReference

571934
kinetic law: 298722
product: 298710
reactant: 298698
reactant: 298686
fast: false
reversible: true
type: Reaction

052661
units: 284709
value: 1.4E-17
type: LocalParameter

291717
stoichiometry: 1.0
species: 561675
type: SpeciesReference

051828
units: 284709
value: 0.0
type: LocalParameter

051696
units: 284709
value: 4.5E-16
type: LocalParameter

293225
stoichiometry: 1.0
species: 564975
type: SpeciesReference

285877
local parameters: 051759
local parameters: 051757
notes: kf*PP1_slash_I1_star_*PP1_slash_PP1_minus_active-kb*PP1_slash_PP1_minus_I1_star_
type: KineticLaw

288260
local parameters: 051908
local parameters: 051906
notes: k1*AMPAR_memb_slash_A845_star__B*CaMKII_slash_actCaMKII_minus_PSD-k2*CaMKII_slash_actCaMKII_minus_PSD_slash_CaMKII_sbo_2_sbc__slash_CaMKII_sbo_2_sbc__cplx
type: KineticLaw

299884
local parameters: 052668
local parameters: 052665
notes: k1*AMPAR_memb_slash_A831_star__B*PP1_PSD_slash_PP1_minus_active_PSD-k2*PP1_PSD_slash_PP1_minus_active_PSD_slash_PP1_sbo_11_sbc__slash_PP1_sbo_11_sbc__cplx
type: KineticLaw

286511
stoichiometry: 1.0
species: 563495
type: SpeciesReference

569454
kinetic law: 292571
product: 292559
product: 292547
reactant: 292535
fast: false
reversible: false
type: Reaction

571074
kinetic law: 296634
product: 296622
product: 296610
reactant: 296598
fast: false
reversible: false
type: Reaction

052494
units: 284793
value: 3.999888E-17
type: LocalParameter

294838
stoichiometry: 1.0
species: 562735
type: SpeciesReference

052620
units: 284793
value: 8.7498E-18
type: LocalParameter

560655
constant: false
boundary condition: false
has only substance units: false
initial concentration: 3.588E-215
initial amount: NaN
in compartment: 560175
type: Species

301260
stoichiometry: 1.0
species: 565175
type: SpeciesReference

291163
local parameters: 052094
local parameters: 052091
notes: k1*PP1_PSD_slash_I1_star_*PP2B_slash_CaM_Ca_n_minus_CaNAB-k2*PP2B_slash_CaM_Ca_n_minus_CaNAB_slash_dephosph_inhib1_PSD_slash_dephosph_inhib1_PSD_cplx
type: KineticLaw

292297
stoichiometry: 1.0
species: 561675
type: SpeciesReference

569414
kinetic law: 292427
product: 292414
reactant: 292401
reactant: 292388
fast: false
reversible: true
type: Reaction

302414
local parameters: 052864
local parameters: 052861
notes: k1*CaM_slash_neurogranin_minus_CaM_PSD*PKC_minus_active-k2*PKC_minus_active_slash_PKC_minus_phosph_minus_ng_minus_CaM_PSD_slash_PKC_minus_phosph_minus_ng_minus_CaM_PSD_cplx
type: KineticLaw

052662
units: 284709
value: 3.5E-18
type: LocalParameter

291488
stoichiometry: 1.0
species: 561675
type: SpeciesReference

294160
stoichiometry: 1.0
species: 562395
type: SpeciesReference

560255
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 560155
type: Species

566455
kinetic law: 285144
product: 285132
reactant: 285120
reactant: 285108
notes: Same as for transloc_1
fast: false
reversible: true
type: Reaction

290872
local parameters: 052076
local parameters: 052073
notes: k1*CaM_slash_neurogranin_star_*PP2B_slash_CaM_Ca_n_minus_CaNAB-k2*PP2B_slash_CaM_Ca_n_minus_CaNAB_slash_dephosph_neurogranin_slash_dephosph_neurogranin_cplx
type: KineticLaw

287442
stoichiometry: 1.0
species: 560315
type: SpeciesReference

301152
stoichiometry: 1.0
species: 564335
type: SpeciesReference

052348
units: 284709
value: 5.4E-16
type: LocalParameter

569494
kinetic law: 292715
product: 292703
reactant: 292691
reactant: 292679
fast: false
reversible: true
type: Reaction

297314
local parameters: 052498
notes: k3*PKA_slash_PKA_minus_active_slash_PKA_sbo_9_sbc__slash_PKA_sbo_9_sbc__cplx
type: KineticLaw

052326
units: 284709
value: 3.24E-15
type: LocalParameter

299568
stoichiometry: 1.0
species: 563755
type: SpeciesReference

298419
stoichiometry: 1.0
species: 563775
type: SpeciesReference

292103
stoichiometry: 1.0
species: 561675
type: SpeciesReference

296273
stoichiometry: 1.0
species: 562655
type: SpeciesReference

569415
kinetic law: 292475
product: 292463
product: 292451
reactant: 292439
fast: false
reversible: false
type: Reaction

051730
units: 284793
value: 2.7000216E-17
type: LocalParameter

051826
units: 284709
value: 3.24E-21
type: LocalParameter

287753
stoichiometry: 1.0
species: 565495
type: SpeciesReference

288332
stoichiometry: 1.0
species: 565595
type: SpeciesReference

298722
local parameters: 052591
local parameters: 052588
notes: k1*CaMKII_slash_CaMKII_star__star__star__minus_PSD*PP1_PSD_slash_PP1_minus_active_PSD-k2*PP1_PSD_slash_PP1_minus_active_PSD_slash_Deph_minus_thr286c_slash_Deph_minus_thr286c_cplx
type: KineticLaw

289156
stoichiometry: 1.0
species: 565015
type: SpeciesReference

298577
local parameters: 052578
notes: k3*PP1_PSD_slash_PP1_minus_active_PSD_slash_Deph_minus_thr286b_slash_Deph_minus_thr286b_cplx
type: KineticLaw

052492
units: 284709
value: 5.4E-16
type: LocalParameter

569874
kinetic law: 293640
product: 293627
product: 293614
reactant: 293602
fast: false
reversible: false
type: Reaction

291886
local parameters: 052138
notes: k3*PP2B_slash_CaM_Ca_n_minus_CaNAB_slash_PP2B_sbo_22_sbc__slash_PP2B_sbo_22_sbc__cplx
type: KineticLaw

291910
stoichiometry: 1.0
species: 561675
type: SpeciesReference

052327
units: 284709
value: 8.1E-16
type: LocalParameter

294221
local parameters: 052292
notes: k3*PP2B_slash_CaM_Ca_n_minus_CaNAB_slash_PP2B_sbo_13_sbc__slash_PP2B_sbo_13_sbc__cplx
type: KineticLaw

052409
units: 284709
value: 5.4E-16
type: LocalParameter

564775
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 560155
type: Species

299206
local parameters: 052623
local parameters: 052620
notes: k1*AMPAR_memb_slash_A831_star_845_star__B845_star_*PP1_PSD_slash_PP1_minus_active_PSD-k2*PP1_PSD_slash_PP1_minus_active_PSD_slash_PP1_sbo_4_sbc__slash_PP1_sbo_4_sbc__cplx
type: KineticLaw

051697
units: 284793
value: 9.001692E-14
type: LocalParameter

289301
stoichiometry: 1.0
species: 565595
type: SpeciesReference

289277
local parameters: 051962
notes: k3*CaMKII_slash_actCaMKII_minus_PSD_slash_CaMKII_sbo_12_sbc__slash_CaMKII_sbo_12_sbc__cplx
type: KineticLaw

300487
stoichiometry: 1.0
species: 565075
type: SpeciesReference

051825
units: 284793
value: 0.0
type: LocalParameter

560535
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 560175
type: Species

286403
stoichiometry: 1.0
species: 562635
type: SpeciesReference

290231
stoichiometry: 1.0
species: 561455
type: SpeciesReference

295912
local parameters: 052408
local parameters: 052405
notes: k1*AMPAR_slash_A831_star__B831_star_845_star_*PKA_slash_PKA_minus_active-k2*PKA_slash_PKA_minus_active_slash_PKA_sbo_27_sbc__slash_PKA_sbo_27_sbc__cplx
type: KineticLaw

566415
kinetic law: 285047
product: 285034
product: 285022
reactant: 285010
notes: Rates set by the translocation experiments of Shen and Meyer, Science 1999.
fast: false
reversible: true
type: Reaction

052292
units: 284709
value: 1.8E-16
type: LocalParameter

298782
stoichiometry: 1.0
species: 565135
type: SpeciesReference

301755
stoichiometry: 1.0
species: 563755
type: SpeciesReference

297155
stoichiometry: 1.0
species: 563215
type: SpeciesReference

285180
local parameters: 051714
local parameters: 051712
notes: kf*CaMKII_slash_basal_CaMKII_PSD_control-kb*CaMKII_slash_basal_CaMKII_PSD
type: KineticLaw

291765
stoichiometry: 1.0
species: 564655
type: SpeciesReference

573094
kinetic law: 301527
product: 301514
reactant: 301502
reactant: 301490
fast: false
reversible: true
type: Reaction

297682
stoichiometry: 1.0
species: 565255
type: SpeciesReference

567495
kinetic law: 287479
product: 287467
reactant: 287454
reactant: 287442
notes: Rates from autocamtide phosphorylation, from Hanson and Schulman JBC 267:24 17216-17224 1992. Jan 1 1998: Speed up 12x to match fig 5.
fast: false
reversible: true
type: Reaction

291813
stoichiometry: 1.0
species: 561675
type: SpeciesReference

560815
constant: false
boundary condition: false
has only substance units: false
initial concentration: 2.04433333333333E-215
initial amount: NaN
in compartment: 560175
type: Species

288901
stoichiometry: 1.0
species: 565175
type: SpeciesReference

052510
units: 284709
value: 5.4E-16
type: LocalParameter

294802
local parameters: 052334
notes: k3*PKA_slash_PKA_minus_active_slash_PKA_minus_phosph_minus_I1_PSD_slash_PKA_minus_phosph_minus_I1_PSD_cplx
type: KineticLaw

051699
units: 284709
value: 9.0E-18
type: LocalParameter

564415
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 560175
type: Species

569714
kinetic law: 293249
product: 293237
product: 293225
reactant: 293213
fast: false
reversible: false
type: Reaction

297215
local parameters: 052492
notes: k3*PKA_slash_PKA_minus_active_slash_PKA_sbo_8_sbc__slash_PKA_sbo_8_sbc__cplx
type: KineticLaw

051835
units: 284709
value: 3.24E-21
type: LocalParameter

293273
stoichiometry: 1.0
species: 561675
type: SpeciesReference

293116
stoichiometry: 1.0
species: 562175
type: SpeciesReference

564495
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 560175
type: Species

294050
stoichiometry: 1.0
species: 561675
type: SpeciesReference

052592
units: 284709
value: 2.5E-17
type: LocalParameter

052138
units: 284709
value: 1.8E-16
type: LocalParameter

286886
stoichiometry: 1.0
species: 564655
type: SpeciesReference

286548
stoichiometry: 1.0
species: 563535
type: SpeciesReference

288454
local parameters: 051919
local parameters: 051917
notes: k1*AMPAR_memb_slash_A845_star__B845_star_*CaMKII_slash_actCaMKII_minus_PSD-k2*CaMKII_slash_actCaMKII_minus_PSD_slash_CaMKII_sbo_4_sbc__slash_CaMKII_sbo_4_sbc__cplx
type: KineticLaw

566875
kinetic law: 286121
product: 286109
reactant: 286097
reactant: 286084
notes: Hasler et al FASEB J 6:2734-2741 1992 say Kd =1e-7M for type II, 5.6e-8 M for type I. Take mean which comes to 2e-13 #/cell Smith et al PNAS USA 78:3 1591-1595 1981 have better data. First kf/kb=2.1e7/M = 3.5e-5 (#/cell). Ogreid and Doskeland Febs Lett 129:2 287-292 1981 have figs suggesting time course of complete assoc is < 1 min.
fast: false
reversible: true
type: Reaction

562115
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0740740740740741
initial amount: NaN
in compartment: 560155
type: Species

290823
local parameters: 052071
notes: k3*PP2B_slash_CaNAB_minus_Ca4_slash_dephosph_inhib1_noCaM_PSD_slash_dephosph_inhib1_noCaM_PSD_cplx
type: KineticLaw

051765
units: 284709
value: 9.0E-17
type: LocalParameter

300232
stoichiometry: 1.0
species: 565115
type: SpeciesReference

562475
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.5
initial amount: NaN
in compartment: 560155
type: Species

290799
stoichiometry: 1.0
species: 563675
type: SpeciesReference

051876
units: 284793
value: 1.5428556E-17
type: LocalParameter

292140
stoichiometry: 1.0
species: 561955
type: SpeciesReference

301611
stoichiometry: 1.0
species: 564435
type: SpeciesReference

052552
units: 284709
value: 7.2E-15
type: LocalParameter

300281
stoichiometry: 1.0
species: 564155
type: SpeciesReference

286231
stoichiometry: 1.0
species: 563635
type: SpeciesReference

301212
stoichiometry: 1.0
species: 563755
type: SpeciesReference

564455
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 560175
type: Species

288707
stoichiometry: 1.0
species: 564975
type: SpeciesReference

296370
stoichiometry: 1.0
species: 562655
type: SpeciesReference

052447
units: 284793
value: 3.999888E-17
type: LocalParameter

299725
stoichiometry: 1.0
species: 563755
type: SpeciesReference

302174
local parameters: 052842
notes: k3*PKC_minus_active_slash_PKC_minus_phosph_minus_ng_minus_CaM_slash_PKC_minus_phosph_minus_ng_minus_CaM_cplx
type: KineticLaw

565715
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 560155
type: Species

052591
units: 284709
value: 1.0E-16
type: LocalParameter

052390
units: 284709
value: 2.16E-15
type: LocalParameter

560855
constant: false
boundary condition: false
has only substance units: false
initial concentration: 1.02566666666667E-215
initial amount: NaN
in compartment: 560175
type: Species

293128
stoichiometry: 1.0
species: 564975
type: SpeciesReference

569274
kinetic law: 291935
product: 291922
reactant: 291910
reactant: 291898
fast: false
reversible: true
type: Reaction

567455
kinetic law: 287394
product: 287382
reactant: 287370
fast: false
reversible: true
type: Reaction

052553
units: 284709
value: 1.8E-15
type: LocalParameter

566675
kinetic law: 285658
product: 285646
reactant: 285634
reactant: 285622
notes: Use K3 = 21.5 uM here from Stemmer and Klee table 3. kb/kf =21.5 * 6e5 so kf = 7.75e-7, kb = 10
fast: false
reversible: true
type: Reaction

290460
stoichiometry: 1.0
species: 561455
type: SpeciesReference

562195
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 560155
type: Species

286121
local parameters: 051774
local parameters: 051772
notes: kf*PKA_slash_R2C2*AC_slash_cAMP-kb*PKA_slash_R2C2_minus_cAMP
type: KineticLaw

302354
stoichiometry: 1.0
species: 564515
type: SpeciesReference

291837
local parameters: 052137
local parameters: 052134
notes: k1*AMPAR_slash_A831_star__B845_star_*PP2B_slash_CaM_Ca_n_minus_CaNAB-k2*PP2B_slash_CaM_Ca_n_minus_CaNAB_slash_PP2B_sbo_22_sbc__slash_PP2B_sbo_22_sbc__cplx
type: KineticLaw

052851
units: 284709
value: 3.6E-16
type: LocalParameter

295766
local parameters: 052397
notes: k3*PKA_slash_PKA_minus_active_slash_PKA_sbo_25_sbc__slash_PKA_sbo_25_sbc__cplx
type: KineticLaw

568175
kinetic law: 289132
product: 289119
reactant: 289106
reactant: 289094
fast: false
reversible: true
type: Reaction

567955
kinetic law: 288598
product: 288586
product: 288574
reactant: 288562
fast: false
reversible: false
type: Reaction

289422
local parameters: 051971
local parameters: 051969
notes: k1*AMPAR_memb_slash_A831_star_845_star__B*CaMKII_slash_actCaMKII_minus_PSD-k2*CaMKII_slash_actCaMKII_minus_PSD_slash_CaMKII_sbo_14_sbc__slash_CaMKII_sbo_14_sbc__cplx
type: KineticLaw

573334
kinetic law: 302114
product: 302102
reactant: 302090
reactant: 302078
notes: Rates are 60% those of PKC-phosph-neurogranin. See Huang et al ABB 305:2 570-580 1993
fast: false
reversible: true
type: Reaction

051874
units: 284709
value: 4.5E-17
type: LocalParameter

290170
stoichiometry: 1.0
species: 561455
type: SpeciesReference

572274
kinetic law: 299543
product: 299531
product: 299519
reactant: 299507
fast: false
reversible: false
type: Reaction

288430
stoichiometry: 1.0
species: 565595
type: SpeciesReference

051987
units: 284709
value: 6.0E-17
type: LocalParameter

285253
stoichiometry: 1.0
species: 561195
type: SpeciesReference

562535
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 560155
type: Species

051834
units: 284709
value: 0.0
type: LocalParameter

562575
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 560155
type: Species

052445
units: 284709
value: 5.4E-16
type: LocalParameter

565795
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 560175
type: Species

052513
units: 284793
value: 3.999888E-17
type: LocalParameter

567555
kinetic law: 287633
product: 287621
product: 287609
reactant: 287596
fast: false
reversible: false
type: Reaction

297718
stoichiometry: 1.0
species: 565015
type: SpeciesReference

291344
stoichiometry: 1.0
species: 561795
type: SpeciesReference

571354
kinetic law: 297314
product: 297301
product: 297288
reactant: 297276
fast: false
reversible: false
type: Reaction

051766
units: 284745
value: 9.00720324E-13
type: LocalParameter

561455
constant: false
boundary condition: false
has only substance units: false
initial concentration: 1.8
initial amount: NaN
in compartment: 560155
type: Species

051873
units: 284709
value: 1.8E-16
type: LocalParameter

288152
stoichiometry: 1.0
species: 560655
type: SpeciesReference

300596
stoichiometry: 1.0
species: 563755
type: SpeciesReference

294718
stoichiometry: 1.0
species: 563675
type: SpeciesReference

564735
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 560155
type: Species

298199
stoichiometry: 1.0
species: 563635
type: SpeciesReference

299411
stoichiometry: 1.0
species: 563975
type: SpeciesReference

301719
local parameters: 052803
local parameters: 052800
notes: k1*AMPAR_memb_slash_A831_star_845_star__B831_star_*PP1_PSD_slash_PP1_minus_active_PSD-k2*PP1_PSD_slash_PP1_minus_active_PSD_slash_PP1_sbo_30_sbc__slash_PP1_sbo_30_sbc__cplx
type: KineticLaw

290122
stoichiometry: 1.0
species: 563735
type: SpeciesReference

560755
constant: false
boundary condition: false
has only substance units: false
initial concentration: 3.588E-215
initial amount: NaN
in compartment: 560175
type: Species

052444
units: 284709
value: 2.16E-15
type: LocalParameter

301332
local parameters: 052769
local parameters: 052766
notes: k1*AMPAR_memb_slash_A831_star_845_star__B831_star_*PP1_PSD_slash_PP1_minus_active_PSD-k2*PP1_PSD_slash_PP1_minus_active_PSD_slash_PP1_sbo_26_sbc__slash_PP1_sbo_26_sbc__cplx
type: KineticLaw

293917
stoichiometry: 1.0
species: 561675
type: SpeciesReference

052597
units: 284709
value: 6.8E-18
type: LocalParameter

290689
stoichiometry: 1.0
species: 561635
type: SpeciesReference

568615
kinetic law: 290195
product: 290183
reactant: 290170
reactant: 290158
fast: false
reversible: true
type: Reaction

300995
local parameters: 052743
notes: k3*PP1_PSD_slash_PP1_minus_active_PSD_slash_PP1_sbo_22_sbc__slash_PP1_sbo_22_sbc__cplx
type: KineticLaw

051831
units: 284709
value: 0.0
type: LocalParameter

289532
stoichiometry: 1.0
species: 560935
type: SpeciesReference

561375
constant: false
boundary condition: false
has only substance units: false
initial concentration: 1.99333333333333E-6
initial amount: NaN
in compartment: 560155
type: Species

293712
stoichiometry: 1.0
species: 565175
type: SpeciesReference

285999
stoichiometry: 2.0
species: 560215
type: SpeciesReference

287813
stoichiometry: 1.0
species: 565495
type: SpeciesReference

296514
stoichiometry: 1.0
species: 565135
type: SpeciesReference

298103
stoichiometry: 1.0
species: 563635
type: SpeciesReference

052393
units: 284793
value: 3.5998992E-16
type: LocalParameter

288816
stoichiometry: 1.0
species: 565595
type: SpeciesReference

284781
exponent: -1.0
scale: 0
multipler: 1.0
kind: SECOND
type: SBMLUnit

302138
stoichiometry: 1.0
species: 560995
type: SpeciesReference

295210
stoichiometry: 1.0
species: 562655
type: SpeciesReference

569934
kinetic law: 293784
product: 293772
reactant: 293760
reactant: 293748
fast: false
reversible: true
type: Reaction

569774
kinetic law: 293396
product: 293384
reactant: 293372
reactant: 293359
fast: false
reversible: true
type: Reaction

561055
constant: false
boundary condition: false
has only substance units: false
initial concentration: 10.0
initial amount: NaN
in compartment: 560155
type: Species

051832
units: 284709
value: 3.24E-21
type: LocalParameter

052854
units: 284793
value: 1.020006E-18
type: LocalParameter

293165
stoichiometry: 1.0
species: 565035
type: SpeciesReference

052247
units: 284709
value: 1.8E-16
type: LocalParameter

052669
units: 284709
value: 3.5E-18
type: LocalParameter

563575
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 560155
type: Species

295090
local parameters: 052354
notes: k3*PKA_slash_PKA_minus_active_slash_PKA_sbo_18_sbc__slash_PKA_sbo_18_sbc__cplx
type: KineticLaw

570234
kinetic law: 294512
product: 294500
product: 294488
reactant: 294475
fast: false
reversible: false
type: Reaction

294002
stoichiometry: 1.0
species: 565000
type: SpeciesReference

287224
stoichiometry: 1.0
species: 565295
type: SpeciesReference

051760
units: 284709
value: 9.0E-17
type: LocalParameter

289700
stoichiometry: 1.0
species: 560975
type: SpeciesReference

297971
stoichiometry: 1.0
species: 563635
type: SpeciesReference

293456
stoichiometry: 1.0
species: 565155
type: SpeciesReference

296841
stoichiometry: 1.0
species: 565055
type: SpeciesReference

052288
units: 284793
value: 2.011824E-17
type: LocalParameter

563955
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 560175
type: Species

294609
local parameters: 052320
notes: k3*PKA_slash_PKA_minus_active_slash_phosph_minus_PDE_slash_phosph_minus_PDE_cplx
type: KineticLaw

290713
stoichiometry: 1.0
species: 561615
type: SpeciesReference

289808
local parameters: 052000
local parameters: 051998
notes: k1*PP1_slash_I1_star_*PP1_slash_PP2A-k2*PP1_slash_PP2A_slash_PP2A_minus_dephosph_minus_I1_slash_PP2A_minus_dephosph_minus_I1_cplx
type: KineticLaw

294754
local parameters: 052333
local parameters: 052330
notes: k1*PP1_PSD_slash_I1*PKA_slash_PKA_minus_active-k2*PKA_slash_PKA_minus_active_slash_PKA_minus_phosph_minus_I1_PSD_slash_PKA_minus_phosph_minus_I1_PSD_cplx
type: KineticLaw

565215
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 560175
type: Species

287188
stoichiometry: 1.0
species: 565215
type: SpeciesReference

052516
units: 284709
value: 2.16E-15
type: LocalParameter

052668
units: 284709
value: 1.4E-17
type: LocalParameter

296622
stoichiometry: 1.0
species: 562655
type: SpeciesReference

563615
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 560195
type: Species

293493
local parameters: 052246
local parameters: 052243
notes: k1*AMPAR_memb_slash_A831_star__B845_star_*PP2B_slash_CaM_Ca_n_minus_CaNAB-k2*PP2B_slash_CaM_Ca_n_minus_CaNAB_slash_PP2B_sbo_6_sbc__slash_PP2B_sbo_6_sbc__cplx
type: KineticLaw

300849
local parameters: 052736
local parameters: 052733
notes: k1*AMPAR_memb_slash_A845_star__B831_star_845_star_*PP1_PSD_slash_PP1_minus_active_PSD-k2*PP1_PSD_slash_PP1_minus_active_PSD_slash_PP1_sbo_21_sbc__slash_PP1_sbo_21_sbc__cplx
type: KineticLaw

051763
units: 284745
value: 3.24008424E-16
type: LocalParameter

570654
kinetic law: 295524
product: 295512
reactant: 295500
reactant: 295488
fast: false
reversible: true
type: Reaction

297827
stoichiometry: 1.0
species: 562655
type: SpeciesReference

296707
stoichiometry: 1.0
species: 565095
type: SpeciesReference

569275
kinetic law: 291983
product: 291971
product: 291959
reactant: 291947
fast: false
reversible: false
type: Reaction

052391
units: 284709
value: 5.4E-16
type: LocalParameter

288116
local parameters: 051899
notes: k3*CaMKII_slash_actCaMKII_minus_PSD_slash_CaMKII_slash_CaMKII_cplx
type: KineticLaw

051870
units: 284793
value: 1.9805958E-18
type: LocalParameter

284805
exponent: 2.0
scale: 0
multipler: 1.0
kind: LITRE
type: SBMLUnit

296117
stoichiometry: 1.0
species: 562995
type: SpeciesReference

293529
stoichiometry: 1.0
species: 561675
type: SpeciesReference

052441
units: 284793
value: 3.999888E-17
type: LocalParameter

288044
stoichiometry: 1.0
species: 565595
type: SpeciesReference

052594
units: 284793
value: 8.7498E-18
type: LocalParameter

286279
stoichiometry: 1.0
species: 562555
type: SpeciesReference

563655
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.08
initial amount: NaN
in compartment: 560175
type: Species

298043
local parameters: 052546
local parameters: 052544
notes: k1*AC_slash_cAMP*AC_slash_cAMP_minus_PDE-k2*AC_slash_cAMP_minus_PDE_slash_PDE_slash_PDE_cplx
type: KineticLaw

052517
units: 284709
value: 5.4E-16
type: LocalParameter

296093
stoichiometry: 1.0
species: 562995
type: SpeciesReference

286341
stoichiometry: 1.0
species: 562655
type: SpeciesReference

290061
stoichiometry: 1.0
species: 563715
type: SpeciesReference

287693
stoichiometry: 1.0
species: 560375
type: SpeciesReference

052249
units: 284793
value: 2.011824E-17
type: LocalParameter

563215
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 560155
type: Species

298637
stoichiometry: 1.0
species: 563815
type: SpeciesReference

052555
units: 284793
value: 1.8900054E-17
type: LocalParameter

051762
units: 284793
value: 0.0
type: LocalParameter

292559
stoichiometry: 1.0
species: 561675
type: SpeciesReference

301490
stoichiometry: 1.0
species: 565255
type: SpeciesReference

292655
stoichiometry: 1.0
species: 561675
type: SpeciesReference

565255
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 560175
type: Species

571854
kinetic law: 298528
product: 298516
reactant: 298504
reactant: 298492
fast: false
reversible: true
type: Reaction

299122
stoichiometry: 1.0
species: 563915
type: SpeciesReference

567015
kinetic law: 286463
product: 286451
reactant: 286439
reactant: 286427
notes: Half-max at 20 nM CaM (Tang et al JBC 266:13 8595-8603 1991 kb/kf = 20 nM = 12000 #/cell so kf = kb/12000 = kb * 8.333e-5
fast: false
reversible: true
type: Reaction

572134
kinetic law: 299206
product: 299194
reactant: 299182
reactant: 299170
fast: false
reversible: true
type: Reaction

052183
units: 284709
value: 1.8E-16
type: LocalParameter

294427
stoichiometry: 1.0
species: 561135
type: SpeciesReference

572874
kinetic law: 300995
product: 300983
product: 300971
reactant: 300958
fast: false
reversible: false
type: Reaction

051729
units: 284709
value: 9.0E-16
type: LocalParameter

296334
stoichiometry: 1.0
species: 562655
type: SpeciesReference

287583
local parameters: 051873
local parameters: 051870
notes: k1*CaMKII_slash_CaMKII_minus_CaM*CaMKII_slash_tot_CaM_CaMKII-k2*CaMKII_slash_tot_CaM_CaMKII_slash_CaM_act_286_slash_CaM_act_286_cplx
type: KineticLaw

052857
units: 284709
value: 2.106E-16
type: LocalParameter

291548
local parameters: 052118
local parameters: 052115
notes: k1*AMPAR_slash_A845_star__B831_star_*PP2B_slash_CaM_Ca_n_minus_CaNAB-k2*PP2B_slash_CaM_Ca_n_minus_CaNAB_slash_PP2B_sbo_19_sbc__slash_PP2B_sbo_19_sbc__cplx
type: KineticLaw

286451
stoichiometry: 1.0
species: 563375
type: SpeciesReference

564915
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 560155
type: Species

296057
local parameters: 052415
notes: k3*PKA_slash_PKA_minus_active_slash_PKA_sbo_28_sbc__slash_PKA_sbo_28_sbc__cplx
type: KineticLaw

293808
stoichiometry: 1.0
species: 565115
type: SpeciesReference

570014
kinetic law: 293978
product: 293966
reactant: 293953
reactant: 293941
fast: false
reversible: true
type: Reaction

561515
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 560155
type: Species

567875
kinetic law: 288405
product: 288393
product: 288381
reactant: 288369
fast: false
reversible: false
type: Reaction

285022
stoichiometry: 1.0
species: 560235
type: SpeciesReference

563395
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 560155
type: Species

296950
stoichiometry: 1.0
species: 562655
type: SpeciesReference

294366
local parameters: 052305
local parameters: 052302
notes: k1*AMPAR_memb_slash_A831_star__B831_star_845_star_*PP2B_slash_CaM_Ca_n_minus_CaNAB-k2*PP2B_slash_CaM_Ca_n_minus_CaNAB_slash_PP2B_sbo_15_sbc__slash_PP2B_sbo_15_sbc__cplx
type: KineticLaw

289857
local parameters: 052003
notes: k3*PP1_slash_PP2A_slash_PP2A_minus_dephosph_minus_I1_slash_PP2A_minus_dephosph_minus_I1_cplx
type: KineticLaw

293565
stoichiometry: 1.0
species: 561675
type: SpeciesReference

572534
kinetic law: 300172
product: 300160
reactant: 300148
reactant: 300136
fast: false
reversible: true
type: Reaction

288962
stoichiometry: 1.0
species: 565195
type: SpeciesReference

052858
units: 284709
value: 5.22E-17
type: LocalParameter

052519
units: 284793
value: 3.999888E-17
type: LocalParameter

300439
stoichiometry: 1.0
species: 563755
type: SpeciesReference

561915
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 560155
type: Species

302462
stoichiometry: 1.0
species: 564515
type: SpeciesReference

298394
stoichiometry: 1.0
species: 560555
type: SpeciesReference

287030
stoichiometry: 1.0
species: 564755
type: SpeciesReference

565000
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 560175
type: Species

567055
kinetic law: 286536
product: 286523
reactant: 286511
notes: The rates for this are poorly constrained. In adipocytes (probably a different PDE) the dephosphorylation is complete within 15 min, but there are no intermediate time points so it could be much faster. Identity of phosphatase etc is still unknown.
fast: false
reversible: true
type: Reaction

052243
units: 284793
value: 2.011824E-17
type: LocalParameter

562095
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 560155
type: Species

294098
stoichiometry: 1.0
species: 565195
type: SpeciesReference

570094
kinetic law: 294172
product: 294160
reactant: 294147
reactant: 294135
fast: false
reversible: true
type: Reaction

052130
units: 284709
value: 7.2E-16
type: LocalParameter

301442
stoichiometry: 1.0
species: 564395
type: SpeciesReference

294790
stoichiometry: 1.0
species: 562655
type: SpeciesReference

299098
stoichiometry: 1.0
species: 563915
type: SpeciesReference

285767
stoichiometry: 1.0
species: 560215
type: SpeciesReference

561675
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 560155
type: Species

298903
stoichiometry: 1.0
species: 563875
type: SpeciesReference

052031
units: 284793
value: 2.2062942E-16
type: LocalParameter

297476
stoichiometry: 1.0
species: 563275
type: SpeciesReference

285839
stoichiometry: 1.0
species: 561295
type: SpeciesReference

572074
kinetic law: 299060
product: 299047
product: 299035
reactant: 299023
fast: false
reversible: false
type: Reaction

562755
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 560155
type: Species

052246
units: 284709
value: 7.2E-16
type: LocalParameter

290303
stoichiometry: 1.0
species: 561495
type: SpeciesReference

301104
stoichiometry: 1.0
species: 565255
type: SpeciesReference

560295
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 560155
type: Species

286169
local parameters: 051777
local parameters: 051775
notes: kf*PKA_slash_R2C2_minus_cAMP*AC_slash_cAMP-kb*PKA_slash_R2C2_minus_cAMP2
type: KineticLaw

287645
stoichiometry: 1.0
species: 560315
type: SpeciesReference

568655
kinetic law: 290291
product: 290279
reactant: 290267
reactant: 290255
fast: false
reversible: true
type: Reaction

052131
units: 284709
value: 1.8E-16
type: LocalParameter

298151
stoichiometry: 1.0
species: 563515
type: SpeciesReference

297416
local parameters: 052504
notes: k3*PKA_slash_PKA_minus_active_slash_PKA_sbo_10_sbc__slash_PKA_sbo_10_sbc__cplx
type: KineticLaw

285950
stoichiometry: 1.0
species: 561595
type: SpeciesReference

299459
stoichiometry: 1.0
species: 565055
type: SpeciesReference

301381
local parameters: 052772
notes: k3*PP1_PSD_slash_PP1_minus_active_PSD_slash_PP1_sbo_26_sbc__slash_PP1_sbo_26_sbc__cplx
type: KineticLaw

568715
kinetic law: 290436
product: 290424
product: 290412
reactant: 290400
fast: false
reversible: false
type: Reaction

567095
kinetic law: 286620
product: 286608
reactant: 286596
notes: Represents diffusion, from a volume of 9e-20 to 5e-18. Assuming neck dimensions of 0.1 x 0.1 microns, this works out to a diffusion const of about 270 um^2/sec, which is pretty conservative. It is what cAMP does in frog cilia.
fast: false
reversible: true
type: Reaction

291308
local parameters: 052101
notes: k3*PP2B_slash_CaM_Ca_n_minus_CaNAB_slash_dephosph_minus_PP1_minus_I_star__PSD_slash_dephosph_minus_PP1_minus_I_star__PSD_cplx
type: KineticLaw

295319
stoichiometry: 1.0
species: 562835
type: SpeciesReference

570054
kinetic law: 294074
product: 294062
reactant: 294050
reactant: 294038
fast: false
reversible: true
type: Reaction

289893
stoichiometry: 1.0
species: 561395
type: SpeciesReference

292764
local parameters: 052197
notes: k3*PP2B_slash_CaM_Ca_n_minus_CaNAB_slash_PP2B_sbo_31_sbc__slash_PP2B_sbo_31_sbc__cplx
type: KineticLaw

052182
units: 284709
value: 7.2E-16
type: LocalParameter

295464
stoichiometry: 1.0
species: 562655
type: SpeciesReference

298528
local parameters: 052577
local parameters: 052574
notes: k1*CaMKII_slash_CaMKII_minus_thr286_minus_PSD*PP1_PSD_slash_PP1_minus_active_PSD-k2*PP1_PSD_slash_PP1_minus_active_PSD_slash_Deph_minus_thr286b_slash_Deph_minus_thr286b_cplx
type: KineticLaw

300124
local parameters: 052684
notes: k3*PP1_PSD_slash_PP1_minus_active_PSD_slash_PP1_sbo_13_sbc__slash_PP1_sbo_13_sbc__cplx
type: KineticLaw

561635
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 560155
type: Species

563315
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 560155
type: Species

298212
stoichiometry: 1.0
species: 563535
type: SpeciesReference

052598
units: 284709
value: 1.7E-18
type: LocalParameter

572934
kinetic law: 301140
product: 301128
reactant: 301116
reactant: 301104
fast: false
reversible: true
type: Reaction

286060
stoichiometry: 1.0
species: 561675
type: SpeciesReference

568475
kinetic law: 289857
product: 289844
product: 289832
reactant: 289820
fast: false
reversible: false
type: Reaction

570994
kinetic law: 296346
product: 296334
product: 296321
reactant: 296309
fast: false
reversible: false
type: Reaction

564275
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 560175
type: Species

291585
stoichiometry: 1.0
species: 561675
type: SpeciesReference

289010
stoichiometry: 1.0
species: 565595
type: SpeciesReference

295258
stoichiometry: 1.0
species: 564735
type: SpeciesReference

286922
stoichiometry: 1.0
species: 564815
type: SpeciesReference

286777
stoichiometry: 1.0
species: 565000
type: SpeciesReference

051769
units: 284793
value: 5.399946E-14
type: LocalParameter

052134
units: 284793
value: 1.8106416E-16
type: LocalParameter

571034
kinetic law: 296490
product: 296478
reactant: 296466
reactant: 296454
fast: false
reversible: true
type: Reaction

297755
local parameters: 052528
local parameters: 052525
notes: k1*AMPAR_memb_slash_A831_star__B831_star_*PKA_slash_PKA_minus_active-k2*PKA_slash_PKA_minus_active_slash_PKA_sbo_14_sbc__slash_PKA_sbo_14_sbc__cplx
type: KineticLaw

563035
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 560155
type: Species

288792
local parameters: 051935
notes: k3*CaMKII_slash_actCaMKII_minus_PSD_slash_CaMKII_sbo_7_sbc__slash_CaMKII_sbo_7_sbc__cplx
type: KineticLaw

571035
kinetic law: 296538
product: 296526
product: 296514
reactant: 296502
fast: false
reversible: false
type: Reaction

563095
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 560155
type: Species

565155
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 560175
type: Species

564675
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 560155
type: Species

294682
stoichiometry: 1.0
species: 561295
type: SpeciesReference

294475
stoichiometry: 1.0
species: 562455
type: SpeciesReference

289748
stoichiometry: 1.0
species: 565615
type: SpeciesReference

052772
units: 284709
value: 3.5E-18
type: LocalParameter

298987
stoichiometry: 1.0
species: 563755
type: SpeciesReference

051879
units: 284709
value: 5.4E-16
type: LocalParameter

570995
kinetic law: 296394
product: 296382
reactant: 296370
reactant: 296358
fast: false
reversible: true
type: Reaction

292971
stoichiometry: 1.0
species: 565135
type: SpeciesReference

565195
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 560175
type: Species

300016
stoichiometry: 1.0
species: 563755
type: SpeciesReference

051984
units: 284709
value: 2.4E-16
type: LocalParameter

290641
stoichiometry: 1.0
species: 561295
type: SpeciesReference

289094
stoichiometry: 1.0
species: 565000
type: SpeciesReference

286656
stoichiometry: 1.0
species: 563755
type: SpeciesReference

052818
units: 284793
value: 2.45142E-17
type: LocalParameter

569514
kinetic law: 292764
product: 292752
product: 292739
reactant: 292727
fast: false
reversible: false
type: Reaction

051768
units: 284709
value: 9.0E-17
type: LocalParameter

573274
kinetic law: 301969
product: 301956
product: 301943
reactant: 301929
fast: false
reversible: false
type: Reaction

294910
stoichiometry: 1.0
species: 564675
type: SpeciesReference

297107
stoichiometry: 1.0
species: 562655
type: SpeciesReference

294536
stoichiometry: 1.0
species: 562655
type: SpeciesReference

051945
units: 284709
value: 2.0E-17
type: LocalParameter

570954
kinetic law: 296249
product: 296237
product: 296225
reactant: 296213
fast: false
reversible: false
type: Reaction

571454
kinetic law: 297562
product: 297549
reactant: 297537
reactant: 297525
fast: false
reversible: true
type: Reaction

285290
stoichiometry: 1.0
species: 560515
type: SpeciesReference

292031
local parameters: 052149
local parameters: 052146
notes: k1*AMPAR_slash_A831_star__B831_star_845_star_*PP2B_slash_CaM_Ca_n_minus_CaNAB-k2*PP2B_slash_CaM_Ca_n_minus_CaNAB_slash_PP2B_sbo_24_sbc__slash_PP2B_sbo_24_sbc__cplx
type: KineticLaw

300172
local parameters: 052689
local parameters: 052686
notes: k1*AMPAR_memb_slash_A_B831_star_845_star_*PP1_PSD_slash_PP1_minus_active_PSD-k2*PP1_PSD_slash_PP1_minus_active_PSD_slash_PP1_sbo_14_sbc__slash_PP1_sbo_14_sbc__cplx
type: KineticLaw

562875
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 560155
type: Species

052189
units: 284709
value: 7.2E-16
type: LocalParameter

052775
units: 284793
value: 8.7498E-18
type: LocalParameter

051878
units: 284709
value: 2.16E-15
type: LocalParameter

285144
local parameters: 051711
local parameters: 051709
notes: kf*CaMKII_slash_CaMKII_minus_thr286_star__minus_CaM*CaMKII_slash_NMDAR-kb*CaMKII_slash_CaMKII_minus_thr286_minus_CaM_minus_PSD
type: KineticLaw

300777
stoichiometry: 1.0
species: 565095
type: SpeciesReference

052241
units: 284709
value: 1.8E-16
type: LocalParameter

560215
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.08
initial amount: NaN
in compartment: 560155
type: Species

296442
local parameters: 052439
notes: k3*PKA_slash_PKA_minus_active_slash_PKA_slash_PKA_cplx
type: KineticLaw

289628
stoichiometry: 1.0
species: 560955
type: SpeciesReference

561115
constant: false
boundary condition: false
has only substance units: false
initial concentration: 10.0
initial amount: NaN
in compartment: 560175
type: Species

572714
kinetic law: 300609
product: 300596
product: 300584
reactant: 300572
fast: false
reversible: false
type: Reaction

051942
units: 284709
value: 5.0E-18
type: LocalParameter

297366
local parameters: 052503
local parameters: 052500
notes: k1*AMPAR_memb_slash_A_B831_star_*PKA_slash_PKA_minus_active-k2*PKA_slash_PKA_minus_active_slash_PKA_sbo_10_sbc__slash_PKA_sbo_10_sbc__cplx
type: KineticLaw

290920
local parameters: 052077
notes: k3*PP2B_slash_CaM_Ca_n_minus_CaNAB_slash_dephosph_neurogranin_slash_dephosph_neurogranin_cplx
type: KineticLaw

299835
local parameters: 052662
notes: k3*PP1_PSD_slash_PP1_minus_active_PSD_slash_PP1_sbo_10_sbc__slash_PP1_sbo_10_sbc__cplx
type: KineticLaw

295102
stoichiometry: 1.0
species: 564915
type: SpeciesReference

291236
stoichiometry: 1.0
species: 561675
type: SpeciesReference

301405
stoichiometry: 1.0
species: 563755
type: SpeciesReference

570614
kinetic law: 295427
product: 295415
reactant: 295403
reactant: 295391
fast: false
reversible: true
type: Reaction

299992
stoichiometry: 1.0
species: 564095
type: SpeciesReference

288755
stoichiometry: 1.0
species: 560775
type: SpeciesReference

293602
stoichiometry: 1.0
species: 562275
type: SpeciesReference

052240
units: 284709
value: 7.2E-16
type: LocalParameter

052186
units: 284793
value: 1.8106416E-16
type: LocalParameter

287609
stoichiometry: 1.0
species: 560275
type: SpeciesReference

570914
kinetic law: 296153
product: 296141
product: 296129
reactant: 296117
fast: false
reversible: false
type: Reaction

287705
stoichiometry: 1.0
species: 560295
type: SpeciesReference

052137
units: 284709
value: 7.2E-16
type: LocalParameter

051982
units: 284793
value: 3.69594E-18
type: LocalParameter

051943
units: 284793
value: 2.77776E-19
type: LocalParameter

295610
stoichiometry: 1.0
species: 562895
type: SpeciesReference

299956
stoichiometry: 1.0
species: 563755
type: SpeciesReference

565415
constant: true
boundary condition: true
has only substance units: false
initial concentration: 0.1
initial amount: NaN
in compartment: 560155
type: Species

299303
local parameters: 052630
local parameters: 052627
notes: k1*AMPAR_memb_slash_A831_star_845_star__B845_star_*PP1_PSD_slash_PP1_minus_active_PSD-k2*PP1_PSD_slash_PP1_minus_active_PSD_slash_PP1_sbo_5_sbc__slash_PP1_sbo_5_sbc__cplx
type: KineticLaw

301188
local parameters: 052756
notes: k3*PP1_PSD_slash_PP1_minus_active_PSD_slash_PP1_sbo_24_sbc__slash_PP1_sbo_24_sbc__cplx
type: KineticLaw

295427
local parameters: 052377
local parameters: 052374
notes: k1*AMPAR_slash_A_B831_star_*PKA_slash_PKA_minus_active-k2*PKA_slash_PKA_minus_active_slash_PKA_sbo_22_sbc__slash_PKA_sbo_22_sbc__cplx
type: KineticLaw

297263
local parameters: 052497
local parameters: 052494
notes: k1*AMPAR_memb_slash_A845_star__B831_star_*PKA_slash_PKA_minus_active-k2*PKA_slash_PKA_minus_active_slash_PKA_sbo_9_sbc__slash_PKA_sbo_9_sbc__cplx
type: KineticLaw

301502
stoichiometry: 1.0
species: 563755
type: SpeciesReference