061112
constant: true
units: 131473
value: 0.1
name: f45
type: Parameter

131424
unit: 131461
unit: 131449
unit: 131437
name: flux
type: SBMLUnitsDef

131485
exponent: -1.0
scale: 0
multipler: 60.0
kind: SECOND
type: SBMLUnit

061055
constant: true
units: 131388
value: 10.0
name: b1
type: Parameter

131583
exponent: 1.0
scale: 0
multipler: 60.0
kind: SECOND
type: SBMLUnit

061091
constant: true
units: 131388
value: 10.0
name: E
type: Parameter

061067
constant: false
units: 131388
value: NaN
name: g2
type: Parameter

061050
constant: true
units: 131424
value: 10.0
name: a1
type: Parameter

061100
constant: true
units: 131473
value: 0.8
name: f24
type: Parameter

061097
constant: true
units: 131473
value: 0.1
name: f14
type: Parameter

061070
constant: true
units: 131388
value: 10.0
name: b2
type: Parameter

061079
constant: true
units: 131497
value: 1.5
name: f53
type: Parameter

131497
unit: 131533
unit: 131521
unit: 131509
name: second_order_rate_constant
type: SBMLUnitsDef

131400
exponent: 1.0
scale: -6
multipler: 1.0
kind: MOLE
type: SBMLUnit

061028
constant: true
units: litre
size: 1.0
spatial dimensions: 3.0
type: Compartment

131449
exponent: -1.0
scale: 0
multipler: 1.0
kind: LITRE
type: SBMLUnit

061124
constant: true
units: 131473
value: 0.001
name: d6
type: Parameter

061082
constant: true
units: 131497
value: 0.6
name: f13
type: Parameter

061109
constant: true
units: 131473
value: 0.3
name: f35
type: Parameter

131412
exponent: -1.0
scale: 0
multipler: 1.0
kind: LITRE
type: SBMLUnit

131533
exponent: -1.0
scale: 0
multipler: 60.0
kind: SECOND
type: SBMLUnit

061058
constant: true
units: 131473
value: 0.2
name: d1
type: Parameter

061064
constant: true
units: 131424
value: 10.0
name: a2
type: Parameter

131509
exponent: -1.0
scale: -6
multipler: 1.0
kind: MOLE
type: SBMLUnit

061094
constant: false
units: 131388
value: 0.0
name: y4
type: Parameter

061115
constant: true
units: 131473
value: 1.0
name: d5
type: Parameter

061061
constant: false
units: 131388
value: 0.0
name: y2
type: Parameter

131521
exponent: 1.0
scale: 0
multipler: 1.0
kind: LITRE
type: SBMLUnit

061049
constant: false
units: 131388
value: 0.0
name: y1
type: Parameter

131570
unit: 131583
name: time
type: SBMLUnitsDef

131558
exponent: 1.0
scale: 0
multipler: 60.0
kind: SECOND
type: SBMLUnit

131437
exponent: 1.0
scale: -6
multipler: 1.0
kind: MOLE
type: SBMLUnit

061118
constant: false
units: 131388
value: 0.0
name: y6
type: Parameter

061103
constant: true
units: 131473
value: 1.1
name: d4
type: Parameter

131461
exponent: -1.0
scale: 0
multipler: 60.0
kind: SECOND
type: SBMLUnit

061088
constant: true
units: 131473
value: 1.0
name: d3
type: Parameter

131546
unit: 131558
name: minute
type: SBMLUnitsDef

131388
unit: 131412
unit: 131400
name: micromolar
type: SBMLUnitsDef

061085
constant: true
units: 131497
value: 0.1
name: h36
type: Parameter

061121
constant: true
units: 131497
value: 0.1
name: h36
type: Parameter

061052
constant: false
units: 131388
value: NaN
name: g1
type: Parameter

061106
constant: false
units: 131388
value: 0.0
name: y5
type: Parameter

131473
unit: 131485
name: first_order_rate_constant
type: SBMLUnitsDef

061076
constant: false
units: 131388
value: 0.0
name: y3
type: Parameter

MODEL8687732743
parameter: 061067
rule: 061030
parameter: 061082
notes: This a model from the article: Network topology determines dynamics of the mammalian MAPK1,2 signaling network: bifan motif regulation of C-Raf and B-Raf isoforms by FGFR and MC1R. Muller M, Obeyesekere M, Mills GB, Ram PT. FASEB J. 2008;22(5):1393-403. 18171696 , Abstract: Activation of the fibroblast growth factor (FGFR) and melanocyte stimulating hormone (MC1R) receptors stimulates B-Raf and C-Raf isoforms that regulate the dynamics of MAPK1,2 signaling. Network topology motifs in mammalian cells include feed-forward and feedback loops and bifans where signals from two upstream molecules integrate to modulate the activity of two downstream molecules. We computationally modeled and experimentally tested signal processing in the FGFR/MC1R/B-Raf/C-Raf/MAPK1,2 network in human melanoma cells; identifying 7 regulatory loops and a bifan motif. Signaling from FGFR leads to sustained activation of MAPK1,2, whereas signaling from MC1R results in transient activation of MAPK1,2. The dynamics of MAPK activation depends critically on the expression level and connectivity to C-Raf, which is critical for a sustained MAPK1,2 response. A partially incoherent bifan motif with a feedback loop acts as a logic gate to integrate signals and regulate duration of activation of the MAPK signaling cascade. Further reducing a 106-node ordinary differential equations network encompassing the complete network to a 6-node network encompassing rate-limiting processes sustains the feedback loops and the bifan, providing sufficient information to predict biological responses. This model was taken from the CellML repository and automatically converted to SBML. The original model was: Muller, Obeyesekere, Mills, Ram. (2008) - version01 The original CellML model was created by: Lloyd, Catherine, May c.lloyd@auckland.ac.nz The University of Auckland Auckland Bioengineering Institute This model originates from BioModels Database: A Database of Annotated Published Models (http://www.ebi.ac.uk/biomode…
parameter: 061115
parameter: 061112
parameter: 061085
rule: 061036
parameter: 061052
units def: 131497
rule: 061033
parameter: 061061
parameter: 061106
curated: false
length unit: length
volume units: 679943
parameter: 061094
rule: 061042
parameter: 061091
parameter: 061076
name: Muller2008_MAPKactivation_Dynamics
area units: area
parameter: 061109
units def: 131424
rule: 061039
substance units: metaid_0000106
units def: 131546
rule: 061048
parameter: 061121
parameter: 061079
parameter: 061050
parameter: 061058
units def: 131388
compartment: 061028
type: SBMLModel
parameter: 061055
parameter: 061070
parameter: 061124
time units: 131570
units def: 131473
parameter: 061097
parameter: 061103
parameter: 061100
parameter: 061088
parameter: 061073
parameter: 061118
units def: 131570
parameter: 061064
rule: 061031
rule: 061045
is described by: http://identifiers.org/pubmed/18171696
parameter: 061049

061073
constant: true
units: 131473
value: 0.1
name: d2
type: Parameter