metaM 6pgl r
name: 6-O-phosphonato-D-glucono-1,5-lactone(2-)
is: SBO:0000247
is: CHEBI:57955
notes: FORMULA: C6H9O9P CHARGE: -2 INCHI: InChI=1S/C6H11O9P/c7-3-2(1-14-16(11,12)13)15-6(10)5(9)4(3)8/h2-5,7-9H,1H2,(H2,11,12,13)/p-2/t2-,3-,4+,5-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00733 EHMN_ABBREVIATION: C01236
boundary condition: false
constant: false
initial concentration: 1.0
is: HMDB01127
initial amount: NaN
has only substance units: false
type: Species

metaR RE2973C
product: MODEL1310110063#
is version of: http://identifiers.org/ec-code/2.7.1.153
notes: GENE_ASSOCIATION: (5290.1) or (5291.1) or (5294.1) or (5289.1) or (5286.1) or (5287.1) or (5288.1) SUBSYSTEM: Phosphatidylinositol phosphate metabolism EC Number: 2.7.1.137 Confidence Level: 0 AUTHORS: PMID:10358929,PMID:11493657,PMID:9043658,PMID:9211928 NOTES:
kinetic law: MODEL1310110063#
is: SBO:0000176
is described by: ECO:0000000
type: Reaction
name: RE2973
is version of: http://identifiers.org/ec-code/2.7.1.137
is version of: http://identifiers.org/ec-code/2.7.1.154
modifier: MODEL1310110063#
reactant: MODEL1310110063#
is version of: http://identifiers.org/ec-code/2.7.11.1
fast: false
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110063#_60f0eab8_d03c_4953_b81a_f034d85a1beb
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:6569
boundary condition: true
name: SLC34A1
constant: false
is: SBO:0000252
has only substance units: false
is: Q7Z725
type: Species

http://identifiers.org/biomodels.db/MODEL1310110063#_f28a1444_ed0e_4fdb_ba45_f5f82291da2b
boundary condition: true
constant: false
has only substance units: false
type: Species
is encoded by: hsa:728226
initial amount: NaN
name: _728226_1_m
is: SBO:0000252
initial concentration: NaN

metaR FAOXC225x
kinetic law: MODEL1310110063#
product: MODEL1310110063#
reactant: MODEL1310110063#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: isomerization(C22:5)x
type: Reaction

metaM sarcs m
is: HMDB00271
is: C00213
constant: false
is: CHEBI:15611
initial concentration: 1.0
has only substance units: false
name: Sarcosine
type: Species
initial amount: NaN
notes: FORMULA: C3H7NO2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00197 EHMN_ABBREVIATION: C00213
boundary condition: false
is: SBO:0000247

metaM co2 x
constant: false
boundary condition: false
name: carbon dioxide
is: CHEBI:16526
initial amount: NaN
notes: FORMULA: CO2 CHARGE: 0 INCHI: InChI=1S/CO2/c2-1-3 HEPATONET_1.0_ABBREVIATION: HC00021 EHMN_ABBREVIATION: C00011
type: Species
has only substance units: false
initial concentration: 1.0
is: SBO:0000247
is: HMDB01967

metaR DGCHOLte
name: bile acid intracellular transport
kinetic law: MODEL1310110063#
product: MODEL1310110063#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 1 AUTHORS: NOTES:unknown mechanism, however bile acids need to be secreted out of the cell NJ
fast: false
reactant: MODEL1310110063#
reversible: true
is described by: ECO:0000000
type: Reaction

metaR EX lcts LPAREN e RPAREN
kinetic law: MODEL1310110063#
reactant: MODEL1310110063#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Lactose exchange
type: Reaction

metaR r2355
name: Organic anion transporter 5 Utilized transport
product: MODEL1310110063#
is: SBO:0000185
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
is described by: ECO:0000000
type: Reaction
fast: false
reactant: MODEL1310110063#
kinetic law: MODEL1310110063#

metaR PPAn
is: SBO:0000176
product: MODEL1310110063#
kinetic law: MODEL1310110063#
reactant: MODEL1310110063#
name: inorganic diphosphatase, nuclear
fast: false
reversible: false
is described by: ECO:0000000
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Miscellaneous EC Number: 3.6.1.1 Confidence Level: 1 AUTHORS: NOTES:

metaM pristanal x
is: CHEBI:49189
has only substance units: false
notes: FORMULA: C19H38O CHARGE: 0 INCHI: InChI=1S/C19H38O/c1-16(2)9-6-10-17(3)11-7-12-18(4)13-8-14-19(5)15-20/h15-19H,6-14H2,1-5H3
initial concentration: 1.0
boundary condition: false
type: Species
constant: false
is: HMDB01958
initial amount: NaN
name: pristanal
is: SBO:0000247

metaR AG13T5g
modifier: MODEL1310110063#
is described by: ECO:0000000
is: SBO:0000176
notes: GENE_ASSOCIATION: (79369.1) or (374907.1) or (11041.1) or (146712.1) or (374907.2) or (93010.1) or (10331.1) or (10678.1) or (10678.2) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.149 Confidence Level: 4 AUTHORS: PMID:10747980,PMID:11042166,PMID:12061784,PMID:12512857,PMID:15560372,PMID:15620693,PMID:9405606 NOTES:NCD
is version of: http://identifiers.org/ec-code/2.4.1.149
type: Reaction
reactant: MODEL1310110063#
fast: false
name: N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase, Golgi apparatus
kinetic law: MODEL1310110063#
product: MODEL1310110063#
reversible: false

metaR EX 3octdece1crn
kinetic law: MODEL1310110063#
reactant: MODEL1310110063#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for 3-hydroxy-octadecenoyl carnitine
type: Reaction

metaM ocdcea e
has only substance units: false
initial concentration: 1.0
is: HMDB00207
notes: FORMULA: C18H33O2 CHARGE: -1
is: CHEBI:0
name: octadecenoate (n-C18:1)
is: C00712
constant: false
type: Species
initial amount: NaN
is: SBO:0000247
boundary condition: false

metaM 3mlda c
is: http://identifiers.org/pubchem.compound/8122
name: 3-Methylimidazoleacetic acid
notes: FORMULA: C6H7N2O2 CHARGE: -1 INCHI: InChI=1/C6H8N2O2/c1-8-3-5(7-4-8)2-6(9)10/h3-4H,2H2,1H3,(H,9,10) EHMN_ABBREVIATION: C05828
has only substance units: false
is: HMDB02820
is: SBO:0000247
is: C05828
initial concentration: 1.0
type: Species
constant: false
boundary condition: false
initial amount: NaN

metaR r2354
type: Reaction
is: SBO:0000185
fast: false
reactant: MODEL1310110063#
kinetic law: MODEL1310110063#
name: Organic anion transporter 5 Utilized transport
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
product: MODEL1310110063#
is described by: ECO:0000000

metaR EX imp LPAREN e RPAREN
kinetic law: MODEL1310110063#
reactant: MODEL1310110063#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: IMP exchange
type: Reaction

metaM 44mzym r
constant: false
initial concentration: 1.0
is: CHEBI:18364
is: SBO:0000247
initial amount: NaN
notes: FORMULA: C29H48O CHARGE: 0 INCHI: InChI=1S/C29H48O/c1-19(2)9-8-10-20(3)22-12-13-23-21-11-14-25-27(4,5)26(30)16-18-29(25,7)24(21)15-17-28(22,23)6/h9,20,22-23,25-26,30H,8,10-18H2,1-7H3/t20-,22-,23+,25+,26+,28-,29-/m1/s1 EHMN_ABBREVIATION: C05108
is: HMDB01286
has only substance units: false
name: 14-demethyllanosterol
boundary condition: false
type: Species

metaR EX aprgstrn LPAREN e RPAREN
kinetic law: MODEL1310110063#
reactant: MODEL1310110063#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 20alpha-Hydroxyprogesterone exchange
type: Reaction

metaM cs e deg2 l
constant: false
type: Species
boundary condition: false
is: HMDB01354
notes: FORMULA: C45H66N2O49S4 CHARGE: -6
has only substance units: false
name: chondroitin sulfate E (GalNAc4,6diS-GlcA), degradation product 2
is: SBO:0000247
is: CHEBI:57455
initial concentration: 1.0
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110063#_04086de8_4585_4ac4_bc6d_f16d0e191f6d
name: PIP5K1A
is encoded by: hsa:8394
is: SBO:0000252
boundary condition: true
initial amount: NaN
initial concentration: NaN
type: Species
has only substance units: false
is: Q99755
constant: false

http://identifiers.org/biomodels.db/MODEL1310110063#_bcd6652f_4461_4045_a510_de3ae0e65799
type: Species
constant: false
is encoded by: hsa:2974
initial amount: NaN
is: SBO:0000252
initial concentration: NaN
has only substance units: false
boundary condition: true
name: GUCY1B2

metaM em2emgacpail hs r
is: HMDB03125
initial concentration: 1.0
type: Species
boundary condition: false
has only substance units: false
is: SBO:0000247
constant: false
notes: FORMULA: C53H100N3O35P3FULLRCO2FULLR2CO2 CHARGE: 0
is: CHEBI:16240
initial amount: NaN
name: (phosphoethanolaminyl-dimannosyl),(phosphoethanolaminyl)-mannosyl-glucosaminyl-acylphosphatidylinositol (H7)

metaR FAOXC221C201x
kinetic law: MODEL1310110063#
product: MODEL1310110063#
reactant: MODEL1310110063#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C22:1-->C20:1)x
type: Reaction

metaR FACOAL246 1
is described by: ECO:0000000
reactant: MODEL1310110063#
product: MODEL1310110063#
kinetic law: MODEL1310110063#
is version of: http://identifiers.org/ec-code/6.2.1.3
fast: false
reversible: true
name: fatty-acid--CoA ligase
notes: GENE_ASSOCIATION: (2180.1) SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 4 AUTHORS: PMID:15292367 NOTES:NJ
is: SBO:0000176
modifier: MODEL1310110063#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110063#_692e2f08_fba3_47a4_aeb2_1b830b80f208
is: Q5HYI4
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:6713
boundary condition: true
constant: false
is: SBO:0000252
name: SQLE
type: Species
has only substance units: false

metaR r2357
kinetic law: MODEL1310110063#
is: SBO:0000185
name: Organic anion transporter 5 Utilized transport
product: MODEL1310110063#
is described by: ECO:0000000
type: Reaction
reversible: true
reactant: MODEL1310110063#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:

metaM ksii core2 deg9 l
initial amount: NaN
name: keratan sulfate II (core 2-linked), degradation product 9
is: CHEBI:12936
initial concentration: 1.0
is: HMDB00143
has only substance units: false
notes: FORMULA: C30H50N3O20X CHARGE: 0
type: Species
is: SBO:0000247
boundary condition: false
constant: false

http://identifiers.org/biomodels.db/MODEL1310110063#_d736c676_173f_4129_88e2_eab6f331de80
constant: false
initial amount: NaN
boundary condition: true
is: P00352
has only substance units: false
name: ALDH1A1
is: SBO:0000252
type: Species
initial concentration: NaN
is encoded by: hsa:216

metaR LEUKTRA4tr
is: SBO:0000185
name: leukotriene intracellular transport
is described by: ECO:0000000
type: Reaction
reactant: MODEL1310110063#
product: MODEL1310110063#
reversible: true
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: NOTES:unknown mechanism, presumed diffusion NJ
kinetic law: MODEL1310110063#

metaM malcoa r
is: SBO:0000247
type: Species
constant: false
has only substance units: false
notes: FORMULA: C24H33N7O19P3S CHARGE: -5 INCHI: InChI=1S/C24H38N7O19P3S/c1-24(2,19(37)22(38)27-4-3-13(32)26-5-6-54-15(35)7-14(33)34)9-47-53(44,45)50-52(42,43)46-8-12-18(49-51(39,40)41)17(36)23(48-12)31-11-30-16-20(25)28-10-29-21(16)31/h10-12,17-19,23,36-37H,3-9H2,1-2H3,(H,26,32)(H,27,38)(H,33,34)(H,42,43)(H,44,45)(H2,25,28,29)(H2,39,40,41)/p-5/t12-,17-,18-,19+,23-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00086 EHMN_ABBREVIATION: C00083
initial amount: NaN
initial concentration: 1.0
is: HMDB01175
name: malonyl-CoA(4-)
is: CHEBI:57384
boundary condition: false

metaM nadph x
name: Nicotinamide adenine dinucleotide phosphate - reduced
notes: FORMULA: C21H26N7O17P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00015 EHMN_ABBREVIATION: C00005
is: CHEBI:57783
type: Species
has only substance units: false
is: HMDB00221
is: C00005
is: SBO:0000247
initial amount: NaN
initial concentration: 1.0
constant: false
boundary condition: false

metaR Htg
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 2 AUTHORS: NOTES:
name: proton diffusion (Golgi)
reactant: MODEL1310110063#
reversible: true
fast: false
type: Reaction
is: SBO:0000185
is described by: ECO:0000000
product: MODEL1310110063#
kinetic law: MODEL1310110063#

metaR EX sarcs LPAREN e RPAREN
kinetic law: MODEL1310110063#
reactant: MODEL1310110063#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Sarcosine exchange
type: Reaction

metaM odecoa m
name: Octadecenoyl-CoA (n-C18:1CoA)
is: HMDB01322
initial concentration: 1.0
has only substance units: false
type: Species
initial amount: NaN
notes: FORMULA: C39H64N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00400 EHMN_ABBREVIATION: C00510
boundary condition: false
is: SBO:0000247
constant: false
is: CHEBI:57387

metaM g6p c
notes: FORMULA: C6H11O9P CHARGE: -2 INCHI: "1/C5H11/c1-3-5-4-2/h1,3-5H2,2H3 HEPATONET_1.0_ABBREVIATION: HC00094 EHMN_ABBREVIATION: C00092
is: SBO:0000247
initial concentration: 1.0
is: C00092
has only substance units: false
is: HMDB01401
type: Species
is: CHEBI:61548
initial amount: NaN
name: D-Glucose 6-phosphate
constant: false
boundary condition: false

metaR r2356
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
reactant: MODEL1310110063#
fast: false
is described by: ECO:0000000
kinetic law: MODEL1310110063#
type: Reaction
is: SBO:0000185
name: Organic anion transporter 5 Utilized transport
reversible: true
product: MODEL1310110063#

metaM 3mlda e
is: http://identifiers.org/pubchem.compound/8122
name: 3-Methylimidazoleacetic acid
notes: FORMULA: C6H7N2O2 CHARGE: -1 INCHI: InChI=1/C6H8N2O2/c1-8-3-5(7-4-8)2-6(9)10/h3-4H,2H2,1H3,(H,9,10) EHMN_ABBREVIATION: C05828
is: HMDB02820
is: SBO:0000247
is: C05828
has only substance units: false
constant: false
initial amount: NaN
type: Species
initial concentration: 1.0
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110063#_9a4912f2_3b95_4990_b1a5_74449228bbe0
boundary condition: true
name: MTMR3
initial amount: NaN
type: Species
is: SBO:0000252
constant: false
is encoded by: hsa:8897
is: Q13615
initial concentration: NaN
has only substance units: false

metaR NDP8ex
modifier: MODEL1310110063#
product: MODEL1310110063#
kinetic law: MODEL1310110063#
reversible: false
is: SBO:0000176
name: nucleoside-diphosphatase (UTP), extracellular
reactant: MODEL1310110063#
fast: false
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/3.6.1.6
type: Reaction
notes: GENE_ASSOCIATION: (124583.1) SUBSYSTEM: Nucleotide interconversion EC Number: 3.6.1.6 Confidence Level: 4 AUTHORS: PMID:12234496,PMID:12600208 NOTES:

metaM 3dhguln c
name: 3-dehydro-L-gulonate
boundary condition: false
has only substance units: false
initial concentration: 1.0
notes: FORMULA: C6H9O7 CHARGE: -1 INCHI: InChI=1S/C6H10O7/c7-1-2(8)3(9)4(10)5(11)6(12)13/h2-3,5,7-9,11H,1H2,(H,12,13)/p-1/t2-,3+,5-/m0/s1
is: SBO:0000247
type: Species
constant: false
is: CHEBI:57655
is: HMDB06334
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110063#_bef4f4ca_d9cb_4983_a821_58c879bf5da5
initial amount: NaN
is encoded by: hsa:9057
name: SLC7A6
constant: false
has only substance units: false
type: Species
boundary condition: true
is: Q92536
initial concentration: NaN
is: SBO:0000252

metaR PPAm
type: Reaction
reactant: MODEL1310110063#
name: inorganic diphosphatase
fast: false
notes: GENE_ASSOCIATION: (27068.4) or (27068.1) or (27068.3) or (27068.2) SUBSYSTEM: Oxidative phosphorylation EC Number: 3.6.1.1 Confidence Level: 4 AUTHORS: PMID:10542310,PMID:15533045 NOTES:IF
reversible: false
is: SBO:0000176
modifier: MODEL1310110063#
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/3.6.1.1
kinetic law: MODEL1310110063#
product: MODEL1310110063#

metaR FUCASE2e
product: MODEL1310110063#
is version of: http://identifiers.org/ec-code/3.2.1.51
is: SBO:0000176
reactant: MODEL1310110063#
modifier: MODEL1310110063#
name: alpha-fucosidase, extracellular
is described by: ECO:0000000
kinetic law: MODEL1310110063#
type: Reaction
reversible: false
fast: false
notes: GENE_ASSOCIATION: (2519.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.51 Confidence Level: 4 AUTHORS: PMID:10460218,PMID:11389735,PMID:12604617,PMID:2317201 NOTES:NCD

metaM odecoa r
has only substance units: false
is: CHEBI:57387
type: Species
notes: FORMULA: C39H64N7O17P3S CHARGE: -4 INCHI: InChI=1S/C39H68N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-30(48)67-23-22-41-29(47)20-21-42-37(51)34(50)39(2,3)25-60-66(57,58)63-65(55,56)59-24-28-33(62-64(52,53)54)32(49)38(61-28)46-27-45-31-35(40)43-26-44-36(31)46/h11-12,26-28,32-34,38,49-50H,4-10,13-25H2,1-3H3,(H,41,47)(H,42,51)(H,55,56)(H,57,58)(H2,40,43,44)(H2,52,53,54)/p-4/b12-11-/t28-,32-,33-,34+,38-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00400 EHMN_ABBREVIATION: C00510
boundary condition: false
constant: false
name: oleoyl-CoA(4-)
initial concentration: 1.0
initial amount: NaN
is: SBO:0000247
is: HMDB01322

metaM leugly c
initial concentration: 1.0
is: http://identifiers.org/pubchem.compound/97364
is: SBO:0000247
has only substance units: false
constant: false
name: Leucylglycine
initial amount: NaN
boundary condition: false
notes: FORMULA: C8H16N2O3 CHARGE: 0
type: Species

metaR FACOAL245 2
reactant: MODEL1310110063#
is: SBO:0000176
is described by: ECO:0000269
name: fatty-acid--CoA ligase
kinetic law: MODEL1310110063#
type: Reaction
product: MODEL1310110063#
notes: GENE_ASSOCIATION: (2180.1) SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 4 AUTHORS: PMID:15292367 NOTES:NJ
reversible: true
modifier: MODEL1310110063#
fast: false
is version of: http://identifiers.org/ec-code/6.2.1.3

metaR EX bilirub LPAREN e RPAREN
kinetic law: MODEL1310110063#
reactant: MODEL1310110063#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Bilirubin exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110063#_ca6ba7e0_c63e_460b_9024_c08d0b23dc93
initial amount: NaN
type: Species
boundary condition: true
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:T83654
name: _T83654_1_c
constant: false
has only substance units: false

metaM n2m2nmn l
constant: false
is: http://identifiers.org/pubchem.compound/3324
is: SBO:0000247
notes: FORMULA: C50H84N4O36 CHARGE: 0
boundary condition: false
initial amount: NaN
name: reducing GlcNAc removed form of n2m2nmasn (w/o peptide)
has only substance units: false
is: CHEBI:15361
is: C00022
initial concentration: 1.0
is: HMDB00243
type: Species

metaR RE3367E
kinetic law: MODEL1310110063#
fast: false
product: MODEL1310110063#
is version of: http://identifiers.org/ec-code/1.4.3.22
name: RE3367
is: SBO:0000176
is described by: ECO:0000000
type: Reaction
reversible: false
modifier: MODEL1310110063#
reactant: MODEL1310110063#
notes: GENE_ASSOCIATION: (26.1) SUBSYSTEM: Urea cycle EC Number: 1.4.3.6 Confidence Level: 0 AUTHORS: PMID:10047787,PMID:7040832 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110063#_551a1deb_cf5e_45da_82cc_0dadca244413
name: B3GALNT1
is: Q49AT3
type: Species
initial amount: NaN
boundary condition: true
is: SBO:0000252
constant: false
initial concentration: NaN
has only substance units: false
is encoded by: hsa:8706

metaR r2359
kinetic law: MODEL1310110063#
product: MODEL1310110063#
fast: false
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
is described by: ECO:0000000
type: Reaction
reactant: MODEL1310110063#
name: Organic anion transporter 5 Utilized transport
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110063#_0481f577_d0f2_4c3b_a286_424f02aea813
initial concentration: NaN
boundary condition: true
initial amount: NaN
name: AK4
has only substance units: false
is: SBO:0000252
constant: false
is encoded by: hsa:205
type: Species
is: P27144

metaM nadph r
boundary condition: false
type: Species
name: Nicotinamide adenine dinucleotide phosphate - reduced
notes: FORMULA: C21H26N7O17P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00015 EHMN_ABBREVIATION: C00005
initial amount: NaN
is: CHEBI:57783
initial concentration: 1.0
is: SBO:0000247
has only substance units: false
is: HMDB00221
is: C00005
constant: false

http://identifiers.org/biomodels.db/MODEL1310110063#_eb28578c_6dd5_4cba_9a0a_b0161b62da33
is encoded by: hsa:23530
is: SBO:0000252
name: NNT
is: Q13423
has only substance units: false
initial amount: NaN
boundary condition: true
constant: false
type: Species
initial concentration: NaN

metaR 3AIBtm
is version of: http://identifiers.org/ec-code/2.6.1.19
reversible: false
type: Reaction
kinetic law: MODEL1310110063#
modifier: MODEL1310110063#
fast: false
reactant: MODEL1310110063#
is described by: ECO:0000000
product: MODEL1310110063#
name: 3-amino-isobutyrate transport, mitochondrial
notes: GENE_ASSOCIATION: (18.1) or (18.2) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: NOTES:
is: SBO:0000185

metaR ALADGLYexR
name: D-alanine/glycine reversible exchange
type: Reaction
kinetic law: MODEL1310110063#
product: MODEL1310110063#
fast: false
modifier: MODEL1310110063#
is: SBO:0000185
notes: GENE_ASSOCIATION: (56301.1) and (6520.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10734121,PMID:10863037,PMID:14770310 NOTES:
is described by: ECO:0000304
reversible: true
reactant: MODEL1310110063#

http://identifiers.org/biomodels.db/MODEL1310110063#_1eb73b2f_31dc_4701_99bf_ddc9754cf52e
is: P14854
boundary condition: true
is encoded by: hsa:1340
initial concentration: NaN
initial amount: NaN
constant: false
has only substance units: false
is: SBO:0000252
name: COX6B1
type: Species

metaR ASPTA
type: Reaction
name: aspartate transaminase
reactant: MODEL1310110063#
kinetic law: MODEL1310110063#
reversible: true
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (2805.1) SUBSYSTEM: Alanine and aspartate metabolism EC Number: 2.6.1.1 Confidence Level: 4 AUTHORS: PMID:2225456,PMID:6930651 NOTES:
is version of: http://identifiers.org/ec-code/2.6.1.1
is: SBO:0000176
product: MODEL1310110063#
modifier: MODEL1310110063#
fast: false

metaR SGALSIDEtg
is described by: ECO:0000000
reactant: MODEL1310110063#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 1 AUTHORS: NOTES:unknown mechanism for transport - however must get to other intracellular compartments (e.g. lysosome for degradation) NJ
reversible: true
product: MODEL1310110063#
name: sgalside hs intracellular transport
fast: false
type: Reaction
kinetic law: MODEL1310110063#

http://identifiers.org/biomodels.db/MODEL1310110063#_73fd3d0b_4158_4a8f_abac_fe79a31003ac
initial concentration: NaN
is: SBO:0000252
type: Species
is encoded by: hsa:5538
initial amount: NaN
is: Q6FGQ4
name: PPT1
boundary condition: true
has only substance units: false
constant: false

metaR r2358
reactant: MODEL1310110063#
reversible: true
name: Organic anion transporter 5 Utilized transport
is: SBO:0000185
kinetic law: MODEL1310110063#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
product: MODEL1310110063#
is described by: ECO:0000000
fast: false
type: Reaction

metaR EX dgmp LPAREN e RPAREN
kinetic law: MODEL1310110063#
reactant: MODEL1310110063#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of dGMP(2-)
type: Reaction

metaR OCOAT1m
reactant: MODEL1310110063#
modifier: MODEL1310110063#
is described by: ECO:0000269
is: SBO:0000176
product: MODEL1310110063#
fast: false
reversible: true
is version of: http://identifiers.org/ec-code/2.8.3.5
type: Reaction
kinetic law: MODEL1310110063#
notes: GENE_ASSOCIATION: (5019.1) or (64064.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 2.8.3.5 Confidence Level: 4 AUTHORS: PMID:10964512,PMID:11756565 NOTES:TDV
name: 3-oxoacid CoA-transferase

http://identifiers.org/biomodels.db/MODEL1310110063#_a33216a8_ecbf_4502_87b5_1365385ea030
is: SBO:0000252
name: ALPPL2
is encoded by: hsa:251
initial concentration: NaN
has only substance units: false
boundary condition: true
constant: false
is: P10696
type: Species
initial amount: NaN

metaR EX idour LPAREN e RPAREN
kinetic law: MODEL1310110063#
reactant: MODEL1310110063#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: Exchange of L-iduronate
type: Reaction

metaM leugly e
boundary condition: false
notes: FORMULA: C8H16N2O3 CHARGE: 0
is: http://identifiers.org/pubchem.compound/97364
initial concentration: 1.0
is: SBO:0000247
constant: false
has only substance units: false
initial amount: NaN
name: Leucylglycine
type: Species

http://identifiers.org/biomodels.db/MODEL1310110063#_f651254b_0a22_4b5e_a5f0_ab35b27fb419
is: Q8NFF5
initial amount: NaN
has only substance units: false
name: FLAD1
type: Species
constant: false
boundary condition: true
is: SBO:0000252
initial concentration: NaN
is encoded by: hsa:80308

metaR EX c4dc
kinetic law: MODEL1310110063#
reactant: MODEL1310110063#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for succinyl carnitine
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110063#_870e93de_297d_4128_9f43_9f5d141bb3d7
initial concentration: NaN
has only substance units: false
boundary condition: true
constant: false
is encoded by: hsa:2109
has part: P38117
type: Species
initial amount: NaN
name: ETFA:ETFB
is: SBO:0000297

metaM leuktrD4 r
boundary condition: false
initial amount: NaN
constant: false
name: Leukotriene D4
initial concentration: 1.0
is: CHEBI:28666
notes: FORMULA: C25H39N2O6S CHARGE: -1 INCHI: InChI=1S/C25H40N2O6S/c1-2-3-4-5-6-7-8-9-10-11-12-13-16-22(21(28)15-14-17-23(29)30)34-19-20(26)25(33)27-18-24(31)32/h6-7,9-13,16,20-22,28H,2-5,8,14-15,17-19,26H2,1H3,(H,27,33)(H,29,30)(H,31,32)/b7-6-,10-9-,12-11+,16-13+/t20-,21-,22+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01664 EHMN_ABBREVIATION: C05951
is: HMDB03080
has only substance units: false
is: SBO:0000247
type: Species

http://identifiers.org/biomodels.db/MODEL1310110063#_e7728d84_a135_44f5_82f7_9cfbf7440a84
initial concentration: NaN
has only substance units: false
is encoded by: hsa:80704
boundary condition: true
constant: false
type: Species
is: SBO:0000252
name: SLC19A3
is: Q9BZV2
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110063#_df03de64_b10d_4bb4_8d5c_bcd16adc2a64
constant: false
name: SLC17A1
has only substance units: false
initial concentration: NaN
is: Q14916
boundary condition: true
is: SBO:0000252
type: Species
initial amount: NaN
is encoded by: hsa:6568

http://identifiers.org/biomodels.db/MODEL1310110063#_93e37a9f_6e66_405d_8b1d_00b66be3e102
boundary condition: true
is encoded by: hsa:3081
has only substance units: false
is: SBO:0000252
name: HGD
initial amount: NaN
initial concentration: NaN
constant: false
type: Species
is: Q93099

metaR GLCMter
type: Reaction
is described by: ECO:0000000
fast: false
reversible: false
is: SBO:0000185
kinetic law: MODEL1310110063#
name: glucose transport via membrane vesicle
reactant: MODEL1310110063#
product: MODEL1310110063#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11882499 NOTES:NCD

metaR EX tag hs LPAREN e RPAREN
kinetic law: MODEL1310110063#
reactant: MODEL1310110063#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: triacylglycerol (homo sapiens) exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110063#_ddfd2ae4_bd79_4319_89c5_43263a3637ee
initial concentration: NaN
boundary condition: true
initial amount: NaN
is encoded by: hsa:23563
name: CHST5
is: SBO:0000252
has only substance units: false
is: Q9GZS9
type: Species
constant: false

metaR ALADGLNexR
fast: false
name: L-alanine/glutamine reversible exchange
type: Reaction
notes: GENE_ASSOCIATION: (56301.1) and (6520.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10734121,PMID:10863037,PMID:14770310 NOTES:
reversible: true
kinetic law: MODEL1310110063#
modifier: MODEL1310110063#
product: MODEL1310110063#
is described by: ECO:0000304
reactant: MODEL1310110063#
is: SBO:0000185

metaR ILEt5m
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:11004451 NOTES:MM
type: Reaction
product: MODEL1310110063#
reversible: true
kinetic law: MODEL1310110063#
reactant: MODEL1310110063#
is: SBO:0000185
name: Isoleucine mitochondrial transport
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110063#_25d7ab32_7e5f_400f_a202_7ac60ce8d76c
is encoded by: hsa:4514
boundary condition: true
initial concentration: NaN
initial amount: NaN
has only substance units: false
is: SBO:0000252
name: COX3
constant: false
is: P00414
type: Species

http://identifiers.org/biomodels.db/MODEL1310110063#_aec24282_34fe_49ce_8a46_c5e980c9b485
constant: false
is encoded by: hsa:957
type: Species
name: ENTPD5
boundary condition: true
initial concentration: NaN
initial amount: NaN
is: O75356
is: SBO:0000252
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110063#_31fc466a_69bd_4094_bb98_71b20f22671b
initial concentration: NaN
has only substance units: false
initial amount: NaN
is encoded by: hsa:10317
constant: false
is: SBO:0000252
boundary condition: true
name: B3GALT5
type: Species

http://identifiers.org/biomodels.db/MODEL1310110063#_294eeb9c_fcb2_4b67_9d92_14f4223d3a4a
boundary condition: true
is: B3KTV4
type: Species
has only substance units: false
initial concentration: NaN
constant: false
name: ADSSL1
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:122622

metaR ADSK
reactant: MODEL1310110063#
notes: GENE_ASSOCIATION: (9060.1) or (9061.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.1.25 Confidence Level: 4 AUTHORS: PMID:11931637,PMID:12716056 NOTES:
kinetic law: MODEL1310110063#
fast: false
name: adenylyl-sulfate kinase
reversible: false
is: SBO:0000176
type: Reaction
modifier: MODEL1310110063#
product: MODEL1310110063#
is version of: http://identifiers.org/ec-code/2.7.1.25
is described by: ECO:0000269

metaM ocdcea l
notes: FORMULA: C18H33O2 CHARGE: -1 INCHI: InChI=1S/C18H34O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20/h9-10H,2-8,11-17H2,1H3,(H,19,20)/p-1/b10-9- HEPATONET_1.0_ABBREVIATION: HC00510 EHMN_ABBREVIATION: C00712
is: CHEBI:30823
initial amount: NaN
constant: false
boundary condition: false
type: Species
initial concentration: 1.0
is: HMDB00207
name: oleate
is: SBO:0000247
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110063#_2a05e8da_056a_4435_b616_6c376a4aff75
is: P35218
is: SBO:0000252
initial concentration: NaN
constant: false
has only substance units: false
initial amount: NaN
type: Species
is encoded by: hsa:763
name: CA5A
boundary condition: true

metaR PRDX
notes: GENE_ASSOCIATION: (8288.1) SUBSYSTEM: Miscellaneous EC Number: 1.11.1.7 Confidence Level: 0 AUTHORS: PMID:10464338 NOTES:RS/TV (6/3/05) Peroxidases can act on a variety of substrates which are oxidized, not just methanol.
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.11.1.7
fast: false
product: MODEL1310110063#
type: Reaction
name: Peroxidase (multiple substrates)
modifier: MODEL1310110063#
reversible: false
reactant: MODEL1310110063#
is described by: ECO:0000000
kinetic law: MODEL1310110063#

metaM so4 c
is: CHEBI:16189
boundary condition: false
constant: false
initial concentration: 1.0
type: Species
name: sulfate
has only substance units: false
is: HMDB01448
notes: FORMULA: O4S CHARGE: -2 INCHI: InChI=1S/H2O4S/c1-5(2,3)4/h(H2,1,2,3,4)/p-2 HEPATONET_1.0_ABBREVIATION: HC00062 EHMN_ABBREVIATION: C00059
initial amount: NaN
is: SBO:0000247

metaR FAS100COA
modifier: MODEL1310110063#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.3.1.85
kinetic law: MODEL1310110063#
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (2194.1) SUBSYSTEM: Fatty acid synthesis EC Number: 2.3.1.86 Confidence Level: 4 AUTHORS: PMID:11756679,PMID:15507492,PMID:2669958 NOTES:NCD
type: Reaction
name: fatty acyl-CoA synthase (n-C10:0CoA)
fast: false
reactant: MODEL1310110063#
product: MODEL1310110063#
reversible: false

metaM ksi pre34 g
type: Species
is: HMDB00175
has only substance units: false
notes: FORMULA: C241H385N17O202S10X CHARGE: -11
is: CHEBI:58053
is: C00130
initial amount: NaN
boundary condition: false
initial concentration: 1.0
name: keratan sulfate I biosynthesis, precursor 34
is: SBO:0000247
constant: false

metaM ksi deg8 l
boundary condition: false
is: HMDB00143
initial amount: NaN
is: SBO:0000247
initial concentration: 1.0
type: Species
has only substance units: false
notes: FORMULA: C194H311N13O171S10 CHARGE: -10
is: CHEBI:12936
constant: false
name: keratan sulfate I, degradation product 8

metaM cs a deg4 l
boundary condition: false
is: SBO:0000247
type: Species
is: HMDB01354
is: CHEBI:57455
name: chondroitin sulfate A (GalNAc4S-GlcA), degradation product 4
notes: FORMULA: C31H49NO29S CHARGE: -2
has only substance units: false
initial concentration: 1.0
initial amount: NaN
constant: false

metaR RE0828E
modifier: MODEL1310110063#
kinetic law: MODEL1310110063#
is version of: http://identifiers.org/ec-code/1.4.3.22
notes: GENE_ASSOCIATION: (26.1) SUBSYSTEM: Urea cycle EC Number: 1.4.3.6 Confidence Level: 0 AUTHORS: PMID:10047787,PMID:7040832 NOTES:
is described by: ECO:0000000
is: SBO:0000176
type: Reaction
product: MODEL1310110063#
fast: false
name: RE0828
reversible: false
reactant: MODEL1310110063#

metaM dmnoncoa c
is: HMDB11604
initial concentration: 1.0
boundary condition: false
notes: FORMULA: C32H54N7O17P3S CHARGE: -4 INCHI: InChI=1/C32H56N7O17P3S/c1-19(2)7-6-8-20(3)9-10-23(41)60-14-13-34-22(40)11-12-35-30(44)27(43)32(4,5)16-53-59(50,51)56-58(48,49)52-15-21-26(55-57(45,46)47)25(42)31(54-21)39-18-38-24-28(33)36-17-37-29(24)39/h17-21,25-27,31,42-43H,6-16H2,1-5H3,(H,34,40)(H,35,44)(H,48,49)(H,50,51)(H2,33,36,37)(H2,45,46,47)/t20?,21-,25-,26-,27?,31-/m1/s1
type: Species
initial amount: NaN
constant: false
name: 4,8 dimethylnonanoyl-CoA
is: SBO:0000247
has only substance units: false

metaR r1640
kinetic law: MODEL1310110063#
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
product: MODEL1310110063#
is described by: ECO:0000000
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reversible: true
type: Reaction
is: SBO:0000185
fast: false
modifier: MODEL1310110063#
reactant: MODEL1310110063#

metaR EX tdcrn
kinetic law: MODEL1310110063#
reactant: MODEL1310110063#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for myristoyl carnitine
type: Reaction

metaM pristcoa x
boundary condition: false
constant: false
initial amount: NaN
name: pristanoyl coa
initial concentration: 1.0
is: SBO:0000247
notes: FORMULA: C40H68N7O17P3S CHARGE: -4 INCHI: InChI=1/C40H72N7O17P3S/c1-25(2)11-8-12-26(3)13-9-14-27(4)15-10-16-28(5)39(52)68-20-19-42-30(48)17-18-43-37(51)34(50)40(6,7)22-61-67(58,59)64-66(56,57)60-21-29-33(63-65(53,54)55)32(49)38(62-29)47-24-46-31-35(41)44-23-45-36(31)47/h23-29,32-34,38,49-50H,8-22H2,1-7H3,(H,42,48)(H,43,51)(H,56,57)(H,58,59)(H2,41,44,45)(H2,53,54,55)/t26?,27?,28?,29-,32-,33-,34+,38-/m1/s1/f/h42-43,53-54,56,58H,41H2
is: CHEBI:51341
has only substance units: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110063#_d24ffe5f_3fdc_4b8e_ae7b_e7cb8dce0ea2
is encoded by: hsa:4716
initial concentration: NaN
constant: false
has only substance units: false
initial amount: NaN
boundary condition: true
type: Species
is: SBO:0000252
name: NDUFB10
is: A8K761

metaR ACNAMtn
kinetic law: MODEL1310110063#
is: SBO:0000185
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD
is described by: ECO:0000000
name: N-acetylneuraminate nuclear import
reactant: MODEL1310110063#
product: MODEL1310110063#
fast: false
reversible: false

metaM tetdece1coa c
notes: FORMULA: C35H56N7O17P3S CHARGE: -4
is: SBO:0000247
initial concentration: 1.0
type: Species
initial amount: NaN
boundary condition: false
name: tetradecenoylcoa
is: HMDB05066
constant: false
has only substance units: false

metaR G5SDym
product: MODEL1310110063#
type: Reaction
is version of: http://identifiers.org/ec-code/1.2.1.41
modifier: MODEL1310110063#
is: SBO:0000176
name: glutamate-5-semialdehyde dehydrogenase (m)
reactant: MODEL1310110063#
notes: GENE_ASSOCIATION: (5832.1) SUBSYSTEM: Urea cycle EC Number: 1.2.1.41 Confidence Level: 2 AUTHORS: PMID:10037775 NOTES:SAB m TDV: name change from G5SDm
kinetic law: MODEL1310110063#
reversible: false
is described by: ECO:0000254
fast: false

metaR r2088
type: Reaction
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
modifier: MODEL1310110063#
is: SBO:0000185
fast: false
reversible: true
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
is described by: ECO:0000000
reactant: MODEL1310110063#
product: MODEL1310110063#
kinetic law: MODEL1310110063#

metaR sink decdicoa LPAREN c RPAREN
kinetic law: MODEL1310110063#
reactant: MODEL1310110063#
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: Sink for 2,6-dodecadienoylcoa(c)
type: Reaction

metaM bilirub c
constant: false
notes: FORMULA: C33H34N4O6 CHARGE: -2 INCHI: InChI=1S/C33H36N4O6/c1-7-20-19(6)32(42)37-27(20)14-25-18(5)23(10-12-31(40)41)29(35-25)15-28-22(9-11-30(38)39)17(4)24(34-28)13-26-16(3)21(8-2)33(43)36-26/h7-8,13-14,34-35H,1-2,9-12,15H2,3-6H3,(H,36,43)(H,37,42)(H,38,39)(H,40,41)/p-2/b26-13-,27-14- HEPATONET_1.0_ABBREVIATION: HC00385 EHMN_ABBREVIATION: C00486
boundary condition: false
is: SBO:0000247
type: Species
is: CHEBI:57977
is: HMDB00054
name: bilirubin(2-)
has only substance units: false
initial concentration: 1.0
initial amount: NaN

metaR r0160
modifier: MODEL1310110063#
fast: false
is: SBO:0000176
product: MODEL1310110063#
notes: GENE_ASSOCIATION: (790.1) SUBSYSTEM: Glycine, serine, alanine and threonine metabolism EC Number: 2.6.1.51 Confidence Level: 0 AUTHORS: PMID:10347152,PMID:6469715 NOTES:
kinetic law: MODEL1310110063#
name: L-Serine:pyruvate aminotransferase Glycine, serine and threonine metabolism EC:2.6.1.51
is described by: ECO:0000000
reversible: false
type: Reaction
is version of: http://identifiers.org/ec-code/2.1.3.2
reactant: MODEL1310110063#

metaM ipdp x
name: isopentenyl diphosphate(3-)
has only substance units: false
boundary condition: false
type: Species
is: HMDB01347
is: SBO:0000247
is: CHEBI:128769
notes: FORMULA: C5H9O7P2 CHARGE: -3 INCHI: InChI=1S/C5H12O7P2/c1-5(2)3-4-11-14(9,10)12-13(6,7)8/h1,3-4H2,2H3,(H,9,10)(H2,6,7,8)/p-3 HEPATONET_1.0_ABBREVIATION: HC00127 EHMN_ABBREVIATION: C00129
initial concentration: 1.0
constant: false
initial amount: NaN

metaM 4ppcys m
notes: FORMULA: C12H20N2O9PS CHARGE: -3 INCHI: InChI=1S/C12H23N2O9PS/c1-12(2,6-23-24(20,21)22)9(16)10(17)13-4-3-8(15)14-7(5-25)11(18)19/h7,9,16,25H,3-6H2,1-2H3,(H,13,17)(H,14,15)(H,18,19)(H2,20,21,22)/p-3/t7-,9-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01276 EHMN_ABBREVIATION: C04352
has only substance units: false
type: Species
constant: false
boundary condition: false
name: N-[(R)-4-phosphonatopantothenoyl]-L-cysteinate(3-)
initial concentration: 1.0
is: SBO:0000247
initial amount: NaN
is: CHEBI:59458
is: HMDB01117

metaM 3hpp m
initial amount: NaN
is: SBO:0000247
notes: FORMULA: C3H5O3 CHARGE: -1 INCHI: InChI=1S/C3H6O3/c4-2-1-3(5)6/h4H,1-2H2,(H,5,6)/p-1 HEPATONET_1.0_ABBREVIATION: HC00625 EHMN_ABBREVIATION: C01013
constant: false
has only substance units: false
is: CHEBI:16510
is: HMDB00700
type: Species
name: 3-hydroxypropionate
boundary condition: false
initial concentration: 1.0

metaR GLYSARCNc
kinetic law: MODEL1310110063#
product: MODEL1310110063#
reactant: MODEL1310110063#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: Hydrolysis of glycylsarcosine for uptake
type: Reaction

metaM leuktrD4 e
initial concentration: 1.0
is: HMDB03080
type: Species
name: Leukotriene D4
has only substance units: false
is: SBO:0000247
initial amount: NaN
notes: FORMULA: C25H39N2O6S CHARGE: -1 INCHI: InChI=1S/C25H40N2O6S/c1-2-3-4-5-6-7-8-9-10-11-12-13-16-22(21(28)15-14-17-23(29)30)34-19-20(26)25(33)27-18-24(31)32/h6-7,9-13,16,20-22,28H,2-5,8,14-15,17-19,26H2,1H3,(H,27,33)(H,29,30)(H,31,32)/b7-6-,10-9-,12-11+,16-13+/t20-,21-,22+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01664 EHMN_ABBREVIATION: C05951
is: CHEBI:28666
boundary condition: false
constant: false

metaR DECCRNe
kinetic law: MODEL1310110063#
product: MODEL1310110063#
reactant: MODEL1310110063#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of 3-hydroxydecanoyl carnitine into extra cellular space
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110063#_d0dc1787_d42c_429a_96f3_501bc3174a6d
constant: false
type: Species
is: P51648
is encoded by: hsa:224
is: SBO:0000252
name: ALDH3A2
has only substance units: false
boundary condition: true
initial concentration: NaN
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110063#_8062e6b2_7769_4f39_ad8b_40ccb9279ac5
initial concentration: NaN
has only substance units: false
initial amount: NaN
is: O14939
name: PLD2
type: Species
boundary condition: true
constant: false
is encoded by: hsa:5338
is: SBO:0000252

metaR EX ddecrn
kinetic law: MODEL1310110063#
reactant: MODEL1310110063#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for lauroyl carnitine
type: Reaction

metaM lac D c
constant: false
is: CHEBI:16004
boundary condition: false
is: HMDB01311
notes: FORMULA: C3H5O3 CHARGE: -1 INCHI: InChI=1S/C3H6O3/c1-2(4)3(5)6/h2,4H,1H3,(H,5,6)/p-1/t2-/m1/s1
name: (R)-lactate
initial amount: NaN
has only substance units: false
type: Species
initial concentration: 1.0
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110063#_3c81fb0f_98a7_447b_ba17_93abb1eeaad5
constant: false
has only substance units: false
initial amount: NaN
is encoded by: hsa:160287
initial concentration: NaN
is: SBO:0000252
type: Species
boundary condition: true
name: LDHAL6A
is: Q6ZMR3

metaR r2087
reversible: true
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
is: SBO:0000185
fast: false
product: MODEL1310110063#
modifier: MODEL1310110063#
kinetic law: MODEL1310110063#
reactant: MODEL1310110063#
type: Reaction

metaR FAOXC226C205m
kinetic law: MODEL1310110063#
product: MODEL1310110063#
reactant: MODEL1310110063#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C22:6-->C20:5)m
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110063#_1147b496_a132_4b69_aafc_cd6312486971
is: E5KS60
type: Species
initial concentration: NaN
initial amount: NaN
is: SBO:0000252
has only substance units: false
name: SUCLA2
constant: false
boundary condition: true
is encoded by: hsa:8803

metaM mi1p D c
boundary condition: false
is: SBO:0000247
is: HMDB02985
initial amount: NaN
initial concentration: 1.0
constant: false
notes: FORMULA: C6H11O9P CHARGE: -2 INCHI: InChI=1S/C6H13O9P/c7-1-2(8)4(10)6(5(11)3(1)9)15-16(12,13)14/h1-11H,(H2,12,13,14)/p-2/t1-,2-,3+,4-,5-,6-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00698
is: CHEBI:58433
type: Species
name: 1D-myo-inositol 1-phosphate(2-)
has only substance units: false

metaR TRDRm
is described by: ECO:0000269
reversible: false
type: Reaction
kinetic law: MODEL1310110063#
modifier: MODEL1310110063#
reactant: MODEL1310110063#
name: thioredoxin reductase (NADPH)
is version of: http://identifiers.org/ec-code/1.8.1.9
notes: GENE_ASSOCIATION: (114112.1) or (10587.1) or (10587.3) or (10587.2) SUBSYSTEM: Nucleotide interconversion EC Number: 1.8.1.9 Confidence Level: 4 AUTHORS: PMID:10215850,PMID:11259642,PMID:12705894 NOTES:NCD
is: SBO:0000176
product: MODEL1310110063#
fast: false

metaR r0308
product: MODEL1310110063#
is: SBO:0000176
name: Palmitoyl-CoA hydrolase Fatty acid elongation in mitochondria EC:3.1.2.22 EC:3.1.2.2
notes: GENE_ASSOCIATION: (6576.1) SUBSYSTEM: Fatty acid oxidation EC Number: 3.1.2.22 Confidence Level: 0 AUTHORS: PMID:10092594,PMID:6151837 NOTES:
reversible: false
modifier: MODEL1310110063#
type: Reaction
reactant: MODEL1310110063#
kinetic law: MODEL1310110063#
fast: false
is described by: ECO:0000000

metaR PYDXtr
type: Reaction
reversible: true
reactant: MODEL1310110063#
is described by: ECO:0000000
name: Pyridoxal transport
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:6380540 NOTES:IT
product: MODEL1310110063#
is: SBO:0000185
kinetic law: MODEL1310110063#

http://identifiers.org/biomodels.db/MODEL1310110063#_fce98346_5c39_4d5e_9041_016eba4ac61d
initial amount: NaN
has only substance units: false
is: P27815
is encoded by: hsa:5141
constant: false
initial concentration: NaN
type: Species
is: SBO:0000252
boundary condition: true
name: PDE4A

http://identifiers.org/biomodels.db/MODEL1310110063#_c601eeeb_8c51_403d_bff1_3fea907b0072
is encoded by: hsa:206
initial amount: NaN
type: Species
constant: false
boundary condition: true
name: _206_1_c
initial concentration: NaN
is: SBO:0000252
has only substance units: false

metaM HC00591 c
initial concentration: 1.0
initial amount: NaN
boundary condition: false
is: CHEBI:16769
type: Species
name: 2-oxoglutaramate
notes: FORMULA: C5H6NO4 CHARGE: -1 INCHI: InChI=1S/C5H7NO4/c6-4(8)2-1-3(7)5(9)10/h1-2H2,(H2,6,8)(H,9,10)/p-1 EHMN_ABBREVIATION: C00940
is: SBO:0000247
has only substance units: false
constant: false

metaM ksii core2 l
initial amount: NaN
is: HMDB01644
has only substance units: false
name: keratan sulfate II (core 2-linked)
initial concentration: 1.0
constant: false
boundary condition: false
is: SBO:0000247
notes: FORMULA: C81H129N6O67S3X CHARGE: -4
is: CHEBI:17140
type: Species

http://identifiers.org/biomodels.db/MODEL1310110063#_3e02d06a_1d99_4ef6_96db_3cfd832bc521
initial amount: NaN
is: O76062
has only substance units: false
initial concentration: NaN
is encoded by: hsa:7108
boundary condition: true
type: Species
is: SBO:0000252
constant: false
name: TM7SF2

http://identifiers.org/biomodels.db/MODEL1310110063#_ac24e9be_6fef_425e_9d56_e1d719704a90
boundary condition: true
has only substance units: false
is: SBO:0000252
name: FUT8
type: Species
initial amount: NaN
is encoded by: hsa:2530
constant: false
initial concentration: NaN
is: G3V5N0

metaM co2 r
constant: false
is: HMDB01967
initial concentration: 1.0
name: CO2
has only substance units: false
is: SBO:0000247
is: C00011
initial amount: NaN
is: CHEBI:16526
boundary condition: false
type: Species
notes: FORMULA: CO2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00021 EHMN_ABBREVIATION: C00011

http://identifiers.org/biomodels.db/MODEL1310110063#_9dffa567_4d20_4420_8498_3ca079efda58
type: Species
initial concentration: NaN
is: P17752
is encoded by: hsa:7166
boundary condition: true
constant: false
is: SBO:0000252
name: TPH1
initial amount: NaN
has only substance units: false

metaM c226crn c
type: Species
notes: FORMULA: C29H45NO4 CHARGE: 0 INCHI: InChI=1/C29H45NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-24-29(33)34-27(25-28(31)32)26-30(2,3)4/h6-7,9-10,12-13,15-16,18-19,21-22,27H,5,8,11,14,17,20,23-26H2,1-4H3/b7-6+,10-9+,13-12+,16-15+,19-18+,22-21+
initial concentration: 1.0
has only substance units: false
is: HMDB06510
boundary condition: false
constant: false
name: cervonyl carnitine
initial amount: NaN
is: SBO:0000247
is: http://identifiers.org/pubchem.compound/127055

http://identifiers.org/biomodels.db/MODEL1310110063#_c00af7f0_1155_4ed4_8f5e_462d76c754ed
is encoded by: hsa:137872
has only substance units: false
boundary condition: true
initial concentration: NaN
is: Q8IWW8
constant: false
initial amount: NaN
name: ADHFE1
is: SBO:0000252
type: Species

metaR PTPATe
kinetic law: MODEL1310110063#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
reactant: MODEL1310110063#
product: MODEL1310110063#
is described by: ECO:0000134
is: SBO:0000176
type: Reaction
reversible: true
name: PTPATe
fast: false

metaM ksi pre2 g
has only substance units: false
notes: FORMULA: C87H142N6O62X CHARGE: -1
type: Species
name: keratan sulfate I biosynthesis, precursor 2
initial amount: NaN
is: CHEBI:58053
is: HMDB00175
is: SBO:0000247
boundary condition: false
constant: false
is: C00130
initial concentration: 1.0

metaR 3SPYRSPm
reactant: MODEL1310110063#
notes: GENE_ASSOCIATION: SUBSYSTEM: Methionine and cysteine metabolism EC Number: Confidence Level: 2 AUTHORS: PMID:3346220 NOTES:MM
name: 3-sulfinopyruvate hydrolase (spotaneous reaction), mitochondrial
fast: false
type: Reaction
is: SBO:0000176
kinetic law: MODEL1310110063#
reversible: false
is described by: ECO:0000000
product: MODEL1310110063#

metaM 3hdcoa c
name: (S)-3-Hydroxydecanoyl-CoA
notes: FORMULA: C31H50N7O18P3S CHARGE: -4
type: Species
is: HMDB00651
constant: false
has only substance units: false
is: SBO:0000247
initial concentration: 1.0
initial amount: NaN
boundary condition: false

metaM thexddcoa m
name: trans7,10-hexadecadienoylcoa
boundary condition: false
initial concentration: 1.0
notes: FORMULA: C37H58N7O17P3S CHARGE: -4
is: SBO:0000247
has only substance units: false
type: Species
constant: false
is: HMDB02288
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110063#_7b4c1cf0_9e37_4655_b790_7ca80df145b8
is: SBO:0000252
initial concentration: NaN
has only substance units: false
boundary condition: true
initial amount: NaN
name: _AI539321_1_c
constant: false
is encoded by: hsa:AI539321
type: Species

http://identifiers.org/biomodels.db/MODEL1310110063#_1adc4af9_9d78_4cf3_a5c9_67d4e90beace
is: P56181
initial concentration: NaN
is encoded by: hsa:4731
initial amount: NaN
boundary condition: true
name: NDUFV3
is: SBO:0000252
constant: false
type: Species
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110063#_f9948b5f_b87e_4c2f_99c6_63d4d8fed276
has only substance units: false
name: GALT
type: Species
is: B2RAT6
is encoded by: hsa:2592
initial concentration: NaN
initial amount: NaN
constant: false
boundary condition: true
is: SBO:0000252

metaR FAOXC102C81m
kinetic law: MODEL1310110063#
product: MODEL1310110063#
reactant: MODEL1310110063#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C10:2-->C8:1)m
type: Reaction

metaR RE3242R
is described by: ECO:0000000
type: Reaction
reversible: true
fast: false
modifier: MODEL1310110063#
name: RE3242
product: MODEL1310110063#
is: SBO:0000176
kinetic law: MODEL1310110063#
reactant: MODEL1310110063#
notes: GENE_ASSOCIATION: (64834.1) SUBSYSTEM: Fatty acid synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:10970790 NOTES:

metaR r0309
notes: GENE_ASSOCIATION: (26.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.1.38 Confidence Level: 0 AUTHORS: PMID:12654921 NOTES:
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/1.4.3.22
is: SBO:0000176
reactant: MODEL1310110063#
reversible: true
modifier: MODEL1310110063#
product: MODEL1310110063#
kinetic law: MODEL1310110063#
name: trans-Hexadec-2-enoyl-CoA reductase Fatty acid elongation in mitochondria EC:1.3.1.38
type: Reaction
fast: false

metaM 5dpmev x
is: SBO:0000247
is: CHEBI:15899
boundary condition: false
name: (R)-5-Diphosphomevalonate
initial concentration: 1.0
is: HMDB01090
constant: false
initial amount: NaN
has only substance units: false
type: Species
notes: FORMULA: C6H10O10P2 CHARGE: -4 INCHI: InChI=1S/C6H14O10P2/c1-6(9,4-5(7)8)2-3-15-18(13,14)16-17(10,11)12/h9H,2-4H2,1H3,(H,7,8)(H,13,14)(H2,10,11,12)/t6-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00685 EHMN_ABBREVIATION: C01143

http://identifiers.org/biomodels.db/MODEL1310110063#_b12430e8_3baf_4bc1_b5d9_711636256313
is: Q99798
name: ACO2
initial concentration: NaN
type: Species
is encoded by: hsa:50
is: SBO:0000252
constant: false
initial amount: NaN
boundary condition: true
has only substance units: false

metaR r2089
modifier: MODEL1310110063#
kinetic law: MODEL1310110063#
reversible: true
is described by: ECO:0000000
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
is: SBO:0000185
fast: false
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
reactant: MODEL1310110063#
type: Reaction
product: MODEL1310110063#

metaR PPNCL3
modifier: MODEL1310110063#
type: Reaction
reversible: false
kinetic law: MODEL1310110063#
is: SBO:0000176
name: phosphopantothenate-cysteine ligase
product: MODEL1310110063#
fast: false
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/6.3.2.5
reactant: MODEL1310110063#
notes: GENE_ASSOCIATION: (79717.1) SUBSYSTEM: CoA synthesis EC Number: Confidence Level: 4 AUTHORS: NOTES:

http://identifiers.org/biomodels.db/MODEL1310110063#_09fce6a1_0efb_4257_97b5_50f3c67547c4
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:10861
boundary condition: true
name: SLC26A1
initial amount: NaN
constant: false
has only substance units: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110063#_2f5d8eb8_363d_4c5a_ad2c_c711c774d9cb
is: P17174
has only substance units: false
constant: false
name: GOT1
is: SBO:0000252
initial concentration: NaN
is encoded by: hsa:2805
boundary condition: true
type: Species
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110063#_d93a2071_73fb_459b_bf20_4272c3905707
is encoded by: hsa:52
type: Species
is: SBO:0000252
has only substance units: false
boundary condition: true
constant: false
initial amount: NaN
name: ACP1
is: B5MCC7
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110063#_67a923a3_72c4_42fe_b4f5_ba34be10e9e3
has only substance units: false
constant: false
type: Species
initial concentration: NaN
name: AGXT2L1
boundary condition: true
is encoded by: hsa:64850
initial amount: NaN
is: Q8TBG4
is: SBO:0000252

metaR FAOXC204C184m
kinetic law: MODEL1310110063#
product: MODEL1310110063#
reactant: MODEL1310110063#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C20:4-->C18:4)m
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110063#_4192aed8_939f_4e25_b704_0b7251c3df08
constant: false
is encoded by: hsa:2876
is: SBO:0000252
name: GPX1
type: Species
initial amount: NaN
has only substance units: false
initial concentration: NaN
boundary condition: true
is: P07203

metaM HC00460 c
constant: false
initial concentration: 1.0
boundary condition: false
type: Species
name: 2,5-dihydroxybenzoate
has only substance units: false
initial amount: NaN
notes: FORMULA: C7H5O4 CHARGE: -1 INCHI: InChI=1S/C7H6O4/c8-4-1-2-6(9)5(3-4)7(10)11/h1-3,8-9H,(H,10,11)/p-1 EHMN_ABBREVIATION: C00628
is: SBO:0000247
is: CHEBI:58044

http://identifiers.org/biomodels.db/MODEL1310110063#_2cd01134_ff15_4e5f_bba3_bfe5f70d6f03
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:8813
has only substance units: false
is: O60762
type: Species
initial amount: NaN
constant: false
boundary condition: true
name: DPM1

metaR EX dpcoa LPAREN e RPAREN
kinetic law: MODEL1310110063#
reactant: MODEL1310110063#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for dpcoa
type: Reaction

metaM tetpent6coa c
is: SBO:0000247
has only substance units: false
name: tetracosapentaenoyl coenzyme A, n-6
initial concentration: 1.0
notes: FORMULA: C45H68N7O17P3S CHARGE: -4 INCHI: InChI=1/C45H72N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-24-25-36(54)73-29-28-47-35(53)26-27-48-43(57)40(56)45(2,3)31-66-72(63,64)69-71(61,62)65-30-34-39(68-70(58,59)60)38(55)44(67-34)52-33-51-37-41(46)49-32-50-42(37)52/h8-9,11-12,14-15,17-18,20-21,32-34,38-40,44,55-56H,4-7,10,13,16,19,22-31H2,1-3H3,(H,47,53)(H,48,57)(H,61,62)(H,63,64)(H2,46,49,50)(H2,58,59,60)/b9-8-,12-11-,15-14-,18-17-,21-20-/t34-,38-,39-,40?,44-/m1/s1
type: Species
initial amount: NaN
constant: false
boundary condition: false
is: C16172

metaR FAOXC18480m
reversible: false
is: SBO:0000176
product: MODEL1310110063#
modifier: MODEL1310110063#
is version of: http://identifiers.org/ec-code/1.3.8.1
is described by: ECO:0000000
fast: false
is version of: http://identifiers.org/ec-code/1.3.99.3
type: Reaction
notes: GENE_ASSOCIATION: (34.1) or (35.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.74 Confidence Level: 4 AUTHORS: NOTES:_5 rounds of beta ox, 4 degrees loss of saturation -> only 1 fad oxidized to fadh2 peroxisomal (very long chain FA) c18:4,n-6 -> c8:0, 4 step FAO lumped for 2 rounds also includes EC 1.1.1.35, 1.1.1.211, 1.3.3.6, 4.2.1.17, 4.2.1.74 NJ
reactant: MODEL1310110063#
name: Beta oxidation of fatty acid
kinetic law: MODEL1310110063#

metaR EX glc LPAREN e RPAREN
kinetic law: MODEL1310110063#
reactant: MODEL1310110063#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: D-Glucose exchange
type: Reaction

metaR r1905
type: Reaction
is described by: ECO:0000000
reactant: MODEL1310110063#
name: Y+LAT2 Utilized transport
is: SBO:0000185
product: MODEL1310110063#
kinetic law: MODEL1310110063#
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
modifier: MODEL1310110063#
reversible: false
fast: false

metaR r1644
kinetic law: MODEL1310110063#
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
fast: false
product: MODEL1310110063#
is described by: ECO:0000000
reversible: true
is: SBO:0000185
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
modifier: MODEL1310110063#
type: Reaction
reactant: MODEL1310110063#

metaR RE3624M
notes: GENE_ASSOCIATION: (51.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.3.6 Confidence Level: 0 AUTHORS: PMID:11356164,PMID:7775433 NOTES:
is: SBO:0000176
is described by: ECO:0000000
reactant: MODEL1310110063#
is version of: http://identifiers.org/ec-code/1.3.3.6
fast: false
reversible: false
product: MODEL1310110063#
name: RE3624
type: Reaction
modifier: MODEL1310110063#
kinetic law: MODEL1310110063#

http://identifiers.org/biomodels.db/MODEL1310110063#_82d1d9d4_042d_488b_9ccb_b53c15ca6253
initial concentration: NaN
is encoded by: hsa:AW277253
is: SBO:0000252
type: Species
initial amount: NaN
boundary condition: true
name: _AW277253_1_c
constant: false
has only substance units: false

metaR GLCter
is described by: ECO:0000000
kinetic law: MODEL1310110063#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: PMID:11879177 NOTES:NCD
reactant: MODEL1310110063#
name: glucose transport, endoplasmic reticulum
is: SBO:0000185
reversible: true
product: MODEL1310110063#
type: Reaction
fast: false

http://identifiers.org/biomodels.db/MODEL1310110063#_5ddddc9b_b831_44d5_bcdc_f53588856604
initial concentration: NaN
boundary condition: true
is: P23919
initial amount: NaN
has only substance units: false
name: DTYMK
is encoded by: hsa:1841
constant: false
type: Species
is: SBO:0000252

metaR r2084
fast: false
type: Reaction
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
is described by: ECO:0000000
modifier: MODEL1310110063#
is: SBO:0000185
kinetic law: MODEL1310110063#
reactant: MODEL1310110063#
reversible: true
product: MODEL1310110063#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110063#_68ddc110_d0ca_477a_b604_e7d825b965cb
is: F8WDN9
constant: false
name: PPA2
initial amount: NaN
type: Species
boundary condition: true
is: SBO:0000252
initial concentration: NaN
is encoded by: hsa:27068
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110063#_ec18539b_0b15_4ded_9eb9_539edb07fdec
boundary condition: true
is: B7Z792
type: Species
name: NDUFS2
is encoded by: hsa:4720
has only substance units: false
initial amount: NaN
is: SBO:0000252
constant: false
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110063#_e4307aa3_60d0_4743_9900_f2902545a601
has only substance units: false
boundary condition: true
is: Q6ZWP6
constant: false
initial amount: NaN
is encoded by: hsa:27034
is: SBO:0000252
type: Species
name: ACAD8
initial concentration: NaN

metaM 5pmev x
is: CHEBI:58146
boundary condition: false
constant: false
initial concentration: 1.0
is: HMDB01343
has only substance units: false
initial amount: NaN
type: Species
name: (R)-5-phosphonatomevalonate(3-)
is: SBO:0000247
notes: FORMULA: C6H10O7P CHARGE: -3 INCHI: InChI=1S/C6H13O7P/c1-6(9,4-5(7)8)2-3-13-14(10,11)12/h9H,2-4H2,1H3,(H,7,8)(H2,10,11,12)/p-3/t6-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00670 EHMN_ABBREVIATION: C01107

metaR RE3301C
is described by: ECO:0000000
type: Reaction
fast: false
modifier: MODEL1310110063#
name: RE3301
is: SBO:0000176
notes: GENE_ASSOCIATION: (5338.1) SUBSYSTEM: Glycerophospholipid metabolism EC Number: 3.1.4.4 Confidence Level: 0 AUTHORS: PMID:11182251 NOTES:
is version of: http://identifiers.org/ec-code/3.1.4.4
kinetic law: MODEL1310110063#
reactant: MODEL1310110063#
product: MODEL1310110063#
reversible: true

metaR ALOX5
reversible: false
product: MODEL1310110063#
fast: false
name: Arachidonate 5-lipoxygenase
kinetic law: MODEL1310110063#
modifier: MODEL1310110063#
reactant: MODEL1310110063#
is: SBO:0000176
notes: GENE_ASSOCIATION: (240.1) SUBSYSTEM: Eicosanoid metabolism EC Number: 1.13.11.34 Confidence Level: 4 AUTHORS: PMID:2829172 NOTES:cofactors + usage still not clear see version ALOX5b for ATP concomittant hydrolysis - literature notes in vitro requirement for Ca and ATP for activity in addition to Fe
is version of: http://identifiers.org/ec-code/1.13.11.34
is described by: ECO:0000269
type: Reaction

metaR RE0958E
reversible: true
notes: GENE_ASSOCIATION: (276.1) or (277.1) or (278.1) or (279.1) or (276.1) or (277.1) or (278.1) or (279.1) or (280.1) or (84569.1) SUBSYSTEM: Starch and sucrose metabolism EC Number: 3.2.1.1 Confidence Level: 0 AUTHORS: PMID:8528071,PMID:890964 NOTES:
kinetic law: MODEL1310110063#
modifier: MODEL1310110063#
fast: false
reactant: MODEL1310110063#
is version of: http://identifiers.org/ec-code/3.2.1.17
is: SBO:0000176
product: MODEL1310110063#
is described by: ECO:0000000
name: RE0958
is version of: http://identifiers.org/ec-code/3.2.1.1
type: Reaction

metaR r1643
product: MODEL1310110063#
is: SBO:0000185
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reactant: MODEL1310110063#
is described by: ECO:0000000
reversible: true
modifier: MODEL1310110063#
kinetic law: MODEL1310110063#
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
fast: false
type: Reaction

metaM 3deccrn e
initial concentration: 1.0
is: HMDB02250
has only substance units: false
is: SBO:0000247
initial amount: NaN
type: Species
notes: FORMULA: C17H33NO5 CHARGE: 0
name: 3-hydroxydecanoylcarnitine
boundary condition: false
constant: false

metaM ksii core2 e
initial concentration: 1.0
boundary condition: false
is: HMDB00211
type: Species
has only substance units: false
initial amount: NaN
notes: FORMULA: C81H129N6O67S3X CHARGE: -4
constant: false
is: CHEBI:17268
name: keratan sulfate II (core 2-linked)
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110063#_a8885634_b66a_43e7_aa1c_e8c0a3277cea
name: GALNTL2
is encoded by: hsa:117248
has only substance units: false
type: Species
is: SBO:0000252
initial concentration: NaN
boundary condition: true
initial amount: NaN
constant: false
is: Q8N3T1

http://identifiers.org/biomodels.db/MODEL1310110063#_930c0ba3_7ac8_4547_98a2_365cf6098a3b
is: Q9UN42
initial concentration: NaN
type: Species
is encoded by: hsa:23439
is: SBO:0000252
boundary condition: true
constant: false
has only substance units: false
initial amount: NaN
name: ATP1B4

metaM urate e
initial concentration: 1.0
is: SBO:0000247
constant: false
name: Urate
type: Species
boundary condition: false
has only substance units: false
notes: FORMULA: C5H4N4O3 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00310 EHMN_ABBREVIATION: C00366
is: HMDB00289
initial amount: NaN
is: C00366
is: CHEBI:17775

metaM ocdcea r
has only substance units: false
notes: FORMULA: C18H33O2 CHARGE: -1
is: C00712
boundary condition: false
initial amount: NaN
name: octadecenoate (n-C18:1)
initial concentration: 1.0
is: CHEBI:0
is: HMDB00207
constant: false
is: SBO:0000247
type: Species

metaR r2083
reactant: MODEL1310110063#
type: Reaction
modifier: MODEL1310110063#
fast: false
reversible: true
is described by: ECO:0000000
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
kinetic law: MODEL1310110063#
product: MODEL1310110063#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
is: SBO:0000185

metaM n2m2mn l
name: de-Fuc, reducing GlcNAc removed, de-Sia, de-Gal form of PA6 (w/o peptide linkage)
is: http://identifiers.org/pubchem.compound/3324
is: HMDB00243
type: Species
is: CHEBI:15361
is: C00022
notes: FORMULA: C42H71N3O31 CHARGE: 0
initial concentration: 1.0
initial amount: NaN
has only substance units: false
constant: false
boundary condition: false
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110063#_945656a4_2a6c_4402_9127_58d533649478
type: Species
initial concentration: NaN
is: SBO:0000252
constant: false
is encoded by: hsa:9365
name: KL
initial amount: NaN
boundary condition: true
has only substance units: false
is: Q9UEF7

metaR sink c81coa LPAREN c RPAREN
kinetic law: MODEL1310110063#
reactant: MODEL1310110063#
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: C81COASINK
type: Reaction

metaM 13dpg c
type: Species
is: SBO:0000247
is: http://identifiers.org/pubchem.compound/3535
is: C00236
is: HMDB01270
has only substance units: false
boundary condition: false
constant: false
name: 3-Phospho-D-glyceroyl phosphate
is: CHEBI:57604
initial amount: NaN
notes: FORMULA: C3H4O10P2 CHARGE: -4 INCHI: 1/C3H8O10P2/c4-2(1-12-14(6,7)8)3(5)13-15(9,10)11/h2,4H,1H2,(H2,6,7,8)(H2,9,10,11)/t2-/m1/s1/f/h6-7,9-10H HEPATONET_1.0_ABBREVIATION: HC00214 EHMN_ABBREVIATION: C00236
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110063#_88ad527c_2524_4590_b3f9_66c2436c6dd0
boundary condition: true
is encoded by: hsa:160728
initial concentration: NaN
constant: false
is: SBO:0000252
has only substance units: false
name: SLC5A8
is: Q8N695
initial amount: NaN
type: Species

metaR r1642
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is described by: ECO:0000000
is: SBO:0000185
product: MODEL1310110063#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reversible: true
fast: false
modifier: MODEL1310110063#
type: Reaction
reactant: MODEL1310110063#
kinetic law: MODEL1310110063#

metaM lnlncacrn c
notes: FORMULA: C25H43NO4 CHARGE: 0 INCHI: InChI=1/C25H43NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-25(29)30-23(26(2,3)4)21-22-24(27)28/h6-7,9-10,12-13,23H,5,8,11,14-22H2,1-4H3/b7-6-,10-9-,13-12-/t23-/m0/s1
boundary condition: false
initial concentration: 1.0
has only substance units: false
initial amount: NaN
is: SBO:0000247
constant: false
is: HMDB06319
type: Species
name: alpha-linolenyl carnitine

metaM ddeccrn c
boundary condition: false
is: HMDB02250
notes: FORMULA: C19H37NO4 CHARGE: 0
name: lauroyl carnitine
type: Species
has only substance units: false
constant: false
is: SBO:0000247
initial concentration: 1.0
initial amount: NaN

metaR DCATDr
kinetic law: MODEL1310110063#
product: MODEL1310110063#
reactant: MODEL1310110063#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: transport of Decanoate (n-C10:0) into the E.R. by diffusion
type: Reaction

metaM thmmp m
boundary condition: false
has only substance units: false
is: HMDB02666
name: thiamine(1+) monophosphate(2-)
initial concentration: 1.0
is: CHEBI:37575
initial amount: NaN
is: SBO:0000247
notes: FORMULA: C12H16N4O4PS CHARGE: -1 INCHI: InChI=1S/C12H17N4O4PS/c1-8-11(3-4-20-21(17,18)19)22-7-16(8)6-10-5-14-9(2)15-12(10)13/h5,7H,3-4,6H2,1-2H3,(H3-,13,14,15,17,18,19)/p-1 EHMN_ABBREVIATION: C01081
type: Species
constant: false

metaM nadph m
is: C00005
type: Species
boundary condition: false
is: CHEBI:57783
name: Nicotinamide adenine dinucleotide phosphate - reduced
constant: false
initial amount: NaN
is: SBO:0000247
initial concentration: 1.0
has only substance units: false
notes: FORMULA: C21H26N7O17P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00015 EHMN_ABBREVIATION: C00005
is: HMDB00221

metaR EX ahdt LPAREN e RPAREN
kinetic law: MODEL1310110063#
reactant: MODEL1310110063#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of 7,8-dihydroneopterin 3-triphosphate(4-)
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110063#_af38ecb6_8ed9_49d2_a6d0_bc62a432fcf3
is: SBO:0000297
is encoded by: hsa:5281
has only substance units: false
is encoded by: hsa:84720
initial amount: NaN
constant: false
boundary condition: true
type: Species
has part: Q8TEQ8
initial concentration: NaN
name: PIGF:PIGO
has part: Q07326

metaR 2HBO
reversible: true
product: MODEL1310110063#
is described by: ECO:0000269
name: 2-Hydroxybutyrate:NAD+ oxidoreductase
modifier: MODEL1310110063#
is version of: http://identifiers.org/ec-code/1.1.1.27
is: SBO:0000176
type: Reaction
fast: false
reactant: MODEL1310110063#
kinetic law: MODEL1310110063#
notes: GENE_ASSOCIATION: (92483.1) or (3948.2) or (55293.1) or (3945.1 and 3939.1) or (3939.1) or (160287.1) or (3945.1) or (3948.1) SUBSYSTEM: Propanoate metabolism EC Number: 1.1.1.27 Confidence Level: 4 AUTHORS: PMID:10108,PMID:21765 NOTES:NCD

metaM bilirub e
type: Species
initial concentration: 1.0
notes: FORMULA: C33H34N4O6 CHARGE: -2 INCHI: InChI=1S/C33H36N4O6/c1-7-20-19(6)32(42)37-27(20)14-25-18(5)23(10-12-31(40)41)29(35-25)15-28-22(9-11-30(38)39)17(4)24(34-28)13-26-16(3)21(8-2)33(43)36-26/h7-8,13-14,34-35H,1-2,9-12,15H2,3-6H3,(H,36,43)(H,37,42)(H,38,39)(H,40,41)/p-2/b26-13-,27-14- HEPATONET_1.0_ABBREVIATION: HC00385 EHMN_ABBREVIATION: C00486
is: SBO:0000247
is: CHEBI:57977
boundary condition: false
is: HMDB00054
initial amount: NaN
name: bilirubin(2-)
has only substance units: false
constant: false

metaR GALt4
product: MODEL1310110063#
fast: false
kinetic law: MODEL1310110063#
modifier: MODEL1310110063#
name: galactose transport via sodium symport
type: Reaction
reactant: MODEL1310110063#
reversible: true
notes: GENE_ASSOCIATION: (200010.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12748858,PMID:15607332 NOTES:NCD
is described by: ECO:0000269
is: SBO:0000185

metaM cmp n
constant: false
is: SBO:0000247
is: CHEBI:60377
boundary condition: false
is: HMDB00095
name: CMP(2-)
has only substance units: false
initial concentration: 1.0
type: Species
initial amount: NaN
notes: FORMULA: C9H12N3O8P CHARGE: -2 INCHI: InChI=1S/C9H14N3O8P/c10-5-1-2-12(9(15)11-5)8-7(14)6(13)4(20-8)3-19-21(16,17)18/h1-2,4,6-8,13-14H,3H2,(H2,10,11,15)(H2,16,17,18)/p-2/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00060 EHMN_ABBREVIATION: C00055

metaR r2086
type: Reaction
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
modifier: MODEL1310110063#
reversible: true
product: MODEL1310110063#
is described by: ECO:0000000
fast: false
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
is: SBO:0000185
reactant: MODEL1310110063#
kinetic law: MODEL1310110063#

metaM itp n
name: ITP(3-)
is: SBO:0000247
constant: false
initial concentration: 1.0
is: CHEBI:57614
boundary condition: false
has only substance units: false
notes: FORMULA: C10H11N4O14P3 CHARGE: -4 INCHI: InChI=1S/C10H15N4O14P3/c15-6-4(1-25-30(21,22)28-31(23,24)27-29(18,19)20)26-10(7(6)16)14-3-13-5-8(14)11-2-12-9(5)17/h2-4,6-7,10,15-16H,1H2,(H,21,22)(H,23,24)(H,11,12,17)(H2,18,19,20)/p-3/t4-,6-,7-,10-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00084 EHMN_ABBREVIATION: C00081
type: Species
initial amount: NaN
is: HMDB00189

http://identifiers.org/biomodels.db/MODEL1310110063#_646458a8_8c66_403a_b8d7_6e67c32d1db5
is encoded by: hsa:2530
is: Q546E0
constant: false
is: SBO:0000252
boundary condition: true
type: Species
initial concentration: NaN
has only substance units: false
name: FUT8
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110063#_9f90ff41_6192_4521_99a2_33d98bb69314
initial concentration: NaN
name: ALDH3B1
type: Species
is: SBO:0000252
boundary condition: true
initial amount: NaN
has only substance units: false
is: P43353
is encoded by: hsa:221
constant: false

metaR RE1531M
type: Reaction
product: MODEL1310110063#
is version of: http://identifiers.org/ec-code/2.3.1.16
reversible: true
is version of: http://identifiers.org/ec-code/4.2.1.17
name: RE1531
reactant: MODEL1310110063#
kinetic law: MODEL1310110063#
is described by: ECO:0000000
fast: false
is: SBO:0000176
notes: GENE_ASSOCIATION: (10449.1) or (3032.1) or (3030.1) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.16 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:7923814,PMID:9568246,PMID:9920399 NOTES:
modifier: MODEL1310110063#

metaM 2obut m
type: Species
initial concentration: 1.0
boundary condition: false
constant: false
is: HMDB00005
initial amount: NaN
notes: FORMULA: C4H5O3 CHARGE: -1 INCHI: InChI=1S/C4H6O3/c1-2-3(5)4(6)7/h2H2,1H3,(H,6,7)/p-1 HEPATONET_1.0_ABBREVIATION: HC00108 EHMN_ABBREVIATION: C00109
has only substance units: false
name: 2-oxobutanoate
is: SBO:0000247
is: CHEBI:16763

metaR RE2973N
name: RE2973
kinetic law: MODEL1310110063#
modifier: MODEL1310110063#
reactant: MODEL1310110063#
type: Reaction
product: MODEL1310110063#
notes: GENE_ASSOCIATION: (5286.1) or (5287.1) or (5288.1) SUBSYSTEM: Phosphatidylinositol phosphate metabolism EC Number: 2.7.1.137 Confidence Level: 0 AUTHORS: PMID:10358929,PMID:11493657,PMID:9043658,PMID:9211928 NOTES:
is: SBO:0000176
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/2.7.1.154
fast: false
reversible: true

metaR ACOAD10m
name: acyl-CoA dehydrogenase (2-methylbutanoyl-CoA), mitochondrial
notes: GENE_ASSOCIATION: (36.1) or (34.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 1.3.99.12 Confidence Level: 4 AUTHORS: PMID:11013134 NOTES:MM
type: Reaction
product: MODEL1310110063#
is described by: ECO:0000269
is: SBO:0000176
reversible: false
reactant: MODEL1310110063#
fast: false
modifier: MODEL1310110063#
kinetic law: MODEL1310110063#
is version of: http://identifiers.org/ec-code/1.3.99.3

metaM ksii core2 g
has only substance units: false
initial concentration: 1.0
is: SBO:0000247
constant: false
is: HMDB01644
initial amount: NaN
notes: FORMULA: C81H129N6O67S3X CHARGE: -4
is: CHEBI:17140
name: keratan sulfate II (core 2-linked)
type: Species
boundary condition: false

metaR PAIL4P HStn
type: Reaction
is: SBO:0000185
kinetic law: MODEL1310110063#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
name: phosphatidylinositol 4-phosphate nuclear transport (diffusion)
product: MODEL1310110063#
reactant: MODEL1310110063#
reversible: true
fast: false

http://identifiers.org/biomodels.db/MODEL1310110063#_67caca01_eab5_4aad_b8ed_69698f0f6afa
name: SLC35A2
is: P78381
constant: false
type: Species
initial amount: NaN
is: SBO:0000252
initial concentration: NaN
boundary condition: true
has only substance units: false
is encoded by: hsa:7355

metaM dcamp c
is: SBO:0000247
notes: FORMULA: C14H14N5O11P CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC01183 EHMN_ABBREVIATION: C03794
boundary condition: false
initial concentration: 1.0
initial amount: NaN
has only substance units: false
type: Species
constant: false
name: N6-(1,2-Dicarboxyethyl)-AMP
is: C03794
is: HMDB00536
is: CHEBI:57567

metaM 3deccrn c
constant: false
is: SBO:0000247
initial amount: NaN
type: Species
notes: FORMULA: C17H33NO5 CHARGE: 0
name: 3-hydroxydecanoylcarnitine
boundary condition: false
has only substance units: false
is: HMDB00651
initial concentration: 1.0

metaR r1641
reversible: true
modifier: MODEL1310110063#
type: Reaction
is: SBO:0000185
product: MODEL1310110063#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
fast: false
reactant: MODEL1310110063#
kinetic law: MODEL1310110063#
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110063#_37f6b4fb_f300_466e_a7aa_17326e127beb
is: SBO:0000252
constant: false
is: P24752
initial amount: NaN
name: ACAT1
is encoded by: hsa:38
boundary condition: true
has only substance units: false
initial concentration: NaN
type: Species

metaM urate c
initial concentration: 1.0
name: Urate
is: HMDB00289
is: CHEBI:17775
is: C00366
boundary condition: false
is: SBO:0000247
has only substance units: false
initial amount: NaN
type: Species
constant: false
notes: FORMULA: C5H4N4O3 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00310 EHMN_ABBREVIATION: C00366

metaM ddeccrn e
notes: FORMULA: C19H37NO4 CHARGE: 0
type: Species
constant: false
is: SBO:0000247
name: lauroyl carnitine
has only substance units: false
boundary condition: false
initial concentration: 1.0
initial amount: NaN
is: HMDB02250

metaM 4aphdob c
is: CHEBI:58147
constant: false
name: 4-(2-aminophenyl)-2,4-dioxobutanoate
notes: FORMULA: C10H8NO4 CHARGE: -1 INCHI: InChI=1S/C10H9NO4/c11-7-4-2-1-3-6(7)8(12)5-9(13)10(14)15/h1-4H,5,11H2,(H,14,15)/p-1 EHMN_ABBREVIATION: C01252
initial concentration: 1.0
is: SBO:0000247
has only substance units: false
is: HMDB00978
type: Species
boundary condition: false
initial amount: NaN

metaM cmp m
is: SBO:0000247
is: CHEBI:60377
has only substance units: false
is: HMDB00095
boundary condition: false
name: CMP(2-)
notes: FORMULA: C9H12N3O8P CHARGE: -2 INCHI: InChI=1S/C9H14N3O8P/c10-5-1-2-12(9(15)11-5)8-7(14)6(13)4(20-8)3-19-21(16,17)18/h1-2,4,6-8,13-14H,3H2,(H2,10,11,15)(H2,16,17,18)/p-2/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00060 EHMN_ABBREVIATION: C00055
type: Species
initial amount: NaN
initial concentration: 1.0
constant: false

metaM co2 m
name: CO2
is: SBO:0000247
has only substance units: false
notes: FORMULA: CO2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00021 EHMN_ABBREVIATION: C00011
is: HMDB01967
boundary condition: false
is: CHEBI:16526
type: Species
initial amount: NaN
initial concentration: 1.0
is: C00011
constant: false

metaR SPHMYLNtg
type: Reaction
reactant: MODEL1310110063#
fast: false
is described by: ECO:0000000
reversible: true
is: SBO:0000185
name: sphingomyelin intracellular transport
product: MODEL1310110063#
kinetic law: MODEL1310110063#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 1 AUTHORS: PMID:15907394 NOTES:unknown mechanism for transport - however must get to other intracellular compartments (e.g. lysosome for degradation) NJ

metaR DPCOAPPe
is described by: ECO:0000134
kinetic law: MODEL1310110063#
notes: GENE_ASSOCIATION: SUBSYSTEM: CoA synthesis EC Number: Confidence Level: AUTHORS: NOTES:
is: SBO:0000176
name: Pyrophasphatase (dephospho-CoA, extracellular)
product: MODEL1310110063#
fast: false
type: Reaction
reversible: false
reactant: MODEL1310110063#

metaM gumgchol e
type: Species
has only substance units: false
is: SBO:0000247
name: guar gum-glycocholate complex
notes: FORMULA: C2760026H5060043NO2530006 CHARGE: 0
boundary condition: false
is: http://identifiers.org/pubchem.compound/93131
initial concentration: 1.0
initial amount: NaN
constant: false

metaR LALDO2x
reactant: MODEL1310110063#
kinetic law: MODEL1310110063#
reversible: false
is described by: ECO:0000269
fast: false
is: SBO:0000176
product: MODEL1310110063#
notes: GENE_ASSOCIATION: (8574.1) SUBSYSTEM: Pyruvate metabolism EC Number: 1.1.1.21 Confidence Level: 4 AUTHORS: PMID:12071861,PMID:9823300 NOTES:AMF
name: D-Lactaldehyde:NAD+ 1-oxidoreductase
type: Reaction
modifier: MODEL1310110063#

http://identifiers.org/biomodels.db/MODEL1310110063#_e882f169_f67c_459d_8ddf_002523196431
is: E9PDK1
type: Species
is: SBO:0000252
initial amount: NaN
has only substance units: false
is encoded by: hsa:83697
name: SLC4A9
constant: false
boundary condition: true
initial concentration: NaN

metaR MAN6PI
modifier: MODEL1310110063#
is version of: http://identifiers.org/ec-code/5.3.1.8
kinetic law: MODEL1310110063#
notes: GENE_ASSOCIATION: (4351.1) SUBSYSTEM: Fructose and mannose metabolism EC Number: 5.3.1.8 Confidence Level: 2 AUTHORS: NOTES:
type: Reaction
product: MODEL1310110063#
reversible: true
is described by: ECO:0000304
is: SBO:0000176
fast: false
name: mannose-6-phosphate isomerase
reactant: MODEL1310110063#

metaR r2085
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
is described by: ECO:0000000
fast: false
modifier: MODEL1310110063#
reversible: true
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
is: SBO:0000185
reactant: MODEL1310110063#
type: Reaction
product: MODEL1310110063#
kinetic law: MODEL1310110063#

metaM tcynt c
notes: FORMULA: CNS CHARGE: -1 INCHI: InChI=1S/CHNS/c2-1-3/h3H/p-1 EHMN_ABBREVIATION: C01755
name: thiocyanate
is: CHEBI:18022
initial concentration: 1.0
has only substance units: false
initial amount: NaN
is: SBO:0000247
constant: false
type: Species
boundary condition: false
is: HMDB01453

metaM xol7ah c
is: SBO:0000247
name: 7alpha-hydroxy-5beta-cholestan-3-one
is: HMDB06892
has only substance units: false
notes: FORMULA: C27H46O2 CHARGE: 0 INCHI: InChI=1S/C27H46O2/c1-17(2)7-6-8-18(3)21-9-10-22-25-23(12-14-27(21,22)5)26(4)13-11-20(28)15-19(26)16-24(25)29/h17-19,21-25,29H,6-16H2,1-5H3/t18-,19+,21-,22+,23+,24-,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01460 EHMN_ABBREVIATION: C05451
is: CHEBI:2290
initial amount: NaN
initial concentration: 1.0
type: Species
boundary condition: false
constant: false

http://identifiers.org/biomodels.db/MODEL1310110063#_9eae431c_b6d3_4a71_ac4c_ef36718fb38a
type: Species
name: UGP2
initial concentration: NaN
is: SBO:0000252
has only substance units: false
is encoded by: hsa:7360
initial amount: NaN
constant: false
boundary condition: true

metaM g6p r
has only substance units: false
is: SBO:0000247
notes: FORMULA: C6H11O9P CHARGE: -2 INCHI: "1/C5H11/c1-3-5-4-2/h1,3-5H2,2H3 HEPATONET_1.0_ABBREVIATION: HC00094 EHMN_ABBREVIATION: C00092
is: C00092
is: CHEBI:61548
name: D-Glucose 6-phosphate
is: HMDB01401
type: Species
initial amount: NaN
boundary condition: false
initial concentration: 1.0
constant: false

metaM atp c
is: CHEBI:30616
initial amount: NaN
name: ATP(4-)
is: SBO:0000247
initial concentration: 1.0
is: HMDB00538
type: Species
is: C00002
has only substance units: false
constant: false
boundary condition: false

metaR METtec
reversible: true
fast: false
is: SBO:0000185
name: L-methionine transport via diffusion (extracellular to cytosol)
modifier: MODEL1310110063#
is described by: ECO:0000269
product: MODEL1310110063#
reactant: MODEL1310110063#
notes: GENE_ASSOCIATION: (8501.1) or (124935.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12930836,PMID:14624363,PMID:15659399 NOTES:SAB
type: Reaction
kinetic law: MODEL1310110063#

metaM 3hexdcrn e
notes: FORMULA: C23H45NO5 CHARGE: 0
initial concentration: 1.0
is: HMDB13336
has only substance units: false
constant: false
is: SBO:0000247
boundary condition: false
initial amount: NaN
name: 3-hydroxyhexadecanoylcarnitine
type: Species

metaR ACACtx
is described by: ECO:0000000
name: acetoacetate intracellular transport unknown mechanism
is: SBO:0000185
product: MODEL1310110063#
reversible: true
reactant: MODEL1310110063#
fast: false
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 1 AUTHORS: NOTES:unknown mechanism NJ
kinetic law: MODEL1310110063#

http://identifiers.org/biomodels.db/MODEL1310110063#_ad9cce98_52c0_434b_8217_1ada1ccf7f57
is encoded by: hsa:5167
has only substance units: false
name: ENPP1
constant: false
initial amount: NaN
type: Species
is: SBO:0000252
is: P22413
initial concentration: NaN
boundary condition: true

metaR ALAGLNNaEx
is described by: ECO:0000269
product: MODEL1310110063#
notes: GENE_ASSOCIATION: (6510.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14530974 NOTES:SAB see Kanai and Hediger 2004 (2003), PMID 14530974
modifier: MODEL1310110063#
type: Reaction
fast: false
reversible: false
kinetic law: MODEL1310110063#
reactant: MODEL1310110063#
name: L-alanine/L-glutamine Na-dependent exchange (Ala-L in)
is: SBO:0000185

metaM so4 m
initial concentration: 1.0
type: Species
boundary condition: false
constant: false
has only substance units: false
is: HMDB01448
notes: FORMULA: O4S CHARGE: -2 INCHI: InChI=1S/H2O4S/c1-5(2,3)4/h(H2,1,2,3,4)/p-2 HEPATONET_1.0_ABBREVIATION: HC00062 EHMN_ABBREVIATION: C00059
name: sulfate
is: SBO:0000247
initial amount: NaN
is: CHEBI:16189

metaR r0157
product: MODEL1310110063#
notes: GENE_ASSOCIATION: (AA502753.1) or (1503.1) or (56474.1) SUBSYSTEM: Urea cycle EC Number: 2.6.1.15 Confidence Level: 0 AUTHORS: PMID:12850267,PMID:1296212,PMID:3003500,PMID:4762917,PMID:4797019,PMID:4822504,PMID:5059882 NOTES:
type: Reaction
is version of: http://identifiers.org/ec-code/6.3.4.2
is described by: ECO:0000000
name: L-Glutamine:pyruvate aminotransferase Glutamate metabolism EC:2.6.1.15
fast: false
modifier: MODEL1310110063#
reversible: false
reactant: MODEL1310110063#
kinetic law: MODEL1310110063#
is: SBO:0000176

metaR EX phe L LPAREN e RPAREN
kinetic law: MODEL1310110063#
reactant: MODEL1310110063#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for L-phenylalanine
type: Reaction

metaR r1647
modifier: MODEL1310110063#
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is: SBO:0000185
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reversible: true
kinetic law: MODEL1310110063#
reactant: MODEL1310110063#
fast: false
product: MODEL1310110063#
is described by: ECO:0000000
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110063#_070e65c3_373d_472a_92e2_12bdd3a6aa54
constant: false
boundary condition: true
initial amount: NaN
is: E9PCP2
name: CPT1B
is encoded by: hsa:1375
initial concentration: NaN
has only substance units: false
type: Species
is: SBO:0000252

metaM ksi pre23 g
initial concentration: 1.0
boundary condition: false
notes: FORMULA: C185H296N13O153S7X CHARGE: -8
is: SBO:0000247
has only substance units: false
type: Species
name: keratan sulfate I biosynthesis, precursor 23
initial amount: NaN
constant: false
is: CHEBI:28067

metaM xylu D c
is: HMDB01644
initial concentration: 1.0
is: SBO:0000247
type: Species
boundary condition: false
has only substance units: false
is: CHEBI:17140
name: D-xylulose
initial amount: NaN
notes: FORMULA: C5H10O5 CHARGE: 0 INCHI: InChI=1S/C5H10O5/c6-1-3(8)5(10)4(9)2-7/h3,5-8,10H,1-2H2/t3-,5+/m1/s1
constant: false

metaR BILIRUBtr
product: MODEL1310110063#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: NOTES:cholesterol precursor, transport by "diffusion" -> actually beleived to be flip-flop mechanism (PMID: 12840657). NJ
kinetic law: MODEL1310110063#
reactant: MODEL1310110063#
fast: false
name: lipid, flip-flop intracellular transport
reversible: true
is: SBO:0000185
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110063#_d57fd7d7_d422_4417_ad9f_963bb1e64781
type: Species
initial concentration: NaN
name: SULT1A3
is: P50224
constant: false
has only substance units: false
is: SBO:0000252
boundary condition: true
is encoded by: hsa:6818
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110063#_e89b9922_1704_4928_8fe2_924ae78f67d3
has only substance units: false
is: Q9BY07
is encoded by: hsa:57835
boundary condition: true
type: Species
initial concentration: NaN
constant: false
initial amount: NaN
name: SLC4A5
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110063#_5ddc3ad4_3a56_4742_b99b_6e58601544d2
name: PDE9A
initial concentration: NaN
is: SBO:0000252
initial amount: NaN
constant: false
type: Species
has only substance units: false
is encoded by: hsa:5152
boundary condition: true

metaR PPM
is: SBO:0000176
is described by: ECO:0000000
fast: false
is version of: http://identifiers.org/ec-code/5.4.2.2
reversible: true
kinetic law: MODEL1310110063#
reactant: MODEL1310110063#
product: MODEL1310110063#
notes: GENE_ASSOCIATION: (5236.1) SUBSYSTEM: Pentose phosphate pathway EC Number: 5.4.2.7 Confidence Level: 0 AUTHORS: NOTES:
modifier: MODEL1310110063#
name: phosphopentomutase
type: Reaction

metaR r2080
reversible: true
kinetic law: MODEL1310110063#
type: Reaction
product: MODEL1310110063#
modifier: MODEL1310110063#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
fast: false
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
is described by: ECO:0000000
is: SBO:0000185
reactant: MODEL1310110063#

metaR r0156
notes: GENE_ASSOCIATION: (H77542.1) or (5313.1) or (5315.1) SUBSYSTEM: Urea cycle EC Number: 2.6.1.15 Confidence Level: 0 AUTHORS: PMID:12850267,PMID:1296212,PMID:3003500,PMID:4762917,PMID:4797019,PMID:4822504,PMID:5059882 NOTES:
fast: false
is: SBO:0000176
type: Reaction
reversible: false
reactant: MODEL1310110063#
is described by: ECO:0000000
kinetic law: MODEL1310110063#
is version of: http://identifiers.org/ec-code/2.7.1.40
name: L-Glutamine:pyruvate aminotransferase Glutamate metabolism EC:2.6.1.15
product: MODEL1310110063#
modifier: MODEL1310110063#

http://identifiers.org/biomodels.db/MODEL1310110063#_c31f7dc9_28fb_4fce_9614_ff5798963218
boundary condition: true
type: Species
is: Q99643
constant: false
initial amount: NaN
initial concentration: NaN
name: SDHC
has only substance units: false
is encoded by: hsa:6391
is: SBO:0000252

metaM xyl D l
is: CHEBI:15936
is: SBO:0000247
boundary condition: false
constant: false
name: aldehydo-D-xylose
type: Species
initial amount: NaN
notes: FORMULA: C5H10O5 CHARGE: 0 INCHI: InChI=1S/C5H10O5/c6-1-3(8)5(10)4(9)2-7/h1,3-5,7-10H,2H2/t3-,4+,5+/m0/s1
has only substance units: false
initial concentration: 1.0

metaR r1648
reversible: true
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is: SBO:0000185
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
type: Reaction
kinetic law: MODEL1310110063#
reactant: MODEL1310110063#
fast: false
modifier: MODEL1310110063#
product: MODEL1310110063#

metaM pail4p hs c
is: CHEBI:58178
initial amount: NaN
constant: false
name: 1-phosphatidyl-1D-myo-inositol 4-phosphate(3-)
notes: FORMULA: C9H15O12P2FULLRCO2FULLR2CO2 CHARGE: -3 EHMN_ABBREVIATION: C01277
boundary condition: false
has only substance units: false
initial concentration: 1.0
is: SBO:0000247
type: Species

http://identifiers.org/biomodels.db/MODEL1310110063#_95ceb279_c1f6_4aa0_a487_a3c2072793ea
initial amount: NaN
name: PDE6B
constant: false
is: SBO:0000252
is: B7Z9T9
has only substance units: false
type: Species
is encoded by: hsa:5158
initial concentration: NaN
boundary condition: true

metaR FAOXC226C227m
kinetic law: MODEL1310110063#
product: MODEL1310110063#
reactant: MODEL1310110063#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C22:6-->C22:7)m
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110063#_ae9bed76_ced8_4f5e_a32c_34767981a471
initial concentration: NaN
has only substance units: false
is encoded by: hsa:4696
type: Species
is: SBO:0000252
initial amount: NaN
is: O95167
constant: false
name: NDUFA3
boundary condition: true

metaM acgam c
name: N-acetyl-D-glucosamine
type: Species
constant: false
boundary condition: false
notes: FORMULA: C8H15NO6 CHARGE: 0 INCHI: InChI=1S/C8H15NO6/c1-4(12)9-5(2-10)7(14)8(15)6(13)3-11/h2,5-8,11,13-15H,3H2,1H3,(H,9,12)/t5-,6+,7+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00138 EHMN_ABBREVIATION: C00140
is: HMDB00215
is: CHEBI:17411
initial amount: NaN
is: SBO:0000247
initial concentration: 1.0
has only substance units: false

metaR RE1519M
name: RE1519
modifier: MODEL1310110063#
reactant: MODEL1310110063#
notes: GENE_ASSOCIATION: (33.1) or (51.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.99.13 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:11356167,PMID:8973539 NOTES:
fast: false
reversible: true
is described by: ECO:0000000
type: Reaction
product: MODEL1310110063#
is version of: http://identifiers.org/ec-code/1.3.3.6
kinetic law: MODEL1310110063#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.3.99.13

metaR r2081
modifier: MODEL1310110063#
is described by: ECO:0000000
kinetic law: MODEL1310110063#
product: MODEL1310110063#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
fast: false
reversible: true
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
is: SBO:0000185
type: Reaction
reactant: MODEL1310110063#

metaM apoC m
is: HMDB00182
type: Species
is: CHEBI:32551
has only substance units: false
name: Apocarboxlase (no lys residue)
initial amount: NaN
notes: FORMULA: XH CHARGE: 0
boundary condition: false
constant: false
initial concentration: 1.0
is: SBO:0000247

metaM e4p c
is: CHEBI:16897
name: D-Erythrose 4-phosphate
has only substance units: false
type: Species
boundary condition: false
constant: false
initial concentration: 1.0
is: C00279
initial amount: NaN
notes: FORMULA: C4H7O7P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00247 EHMN_ABBREVIATION: C00279
is: SBO:0000247
is: HMDB01321

http://identifiers.org/biomodels.db/MODEL1310110063#_abc57320_9258_4188_a561_15f55fae1217
is: E9KL42
initial concentration: NaN
initial amount: NaN
constant: false
has only substance units: false
type: Species
boundary condition: true
name: ACOT1
is encoded by: hsa:641371
is: SBO:0000252

metaR r1645
type: Reaction
kinetic law: MODEL1310110063#
modifier: MODEL1310110063#
is: SBO:0000185
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reactant: MODEL1310110063#
reversible: true
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
product: MODEL1310110063#
fast: false

metaR FAOXC164GC163m
kinetic law: MODEL1310110063#
product: MODEL1310110063#
reactant: MODEL1310110063#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C16:4-->C16:3)gm
type: Reaction

metaM ksi deg35 l
name: keratan sulfate I, degradation product 35
initial amount: NaN
type: Species
is: SBO:0000247
is: HMDB00143
is: CHEBI:12936
constant: false
boundary condition: false
has only substance units: false
initial concentration: 1.0
notes: FORMULA: C68H113N4O54S1 CHARGE: -1

metaR EX nrpphrsf LPAREN e RPAREN
kinetic law: MODEL1310110063#
reactant: MODEL1310110063#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Sulfate derivative of norepinephrine exchange
type: Reaction

metaM tre e
is: HMDB00975
has only substance units: false
initial concentration: 1.0
is: C01083
notes: FORMULA: C12H22O11 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00658 EHMN_ABBREVIATION: C01083
type: Species
name: Trehalose
is: CHEBI:16551
constant: false
is: SBO:0000247
boundary condition: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110063#_9d7b0e27_6ed3_4f08_a418_3df42fff6b16
is: SBO:0000252
has only substance units: false
boundary condition: true
constant: false
is encoded by: hsa:7991
type: Species
initial concentration: NaN
initial amount: NaN
name: TUSC3

http://identifiers.org/biomodels.db/MODEL1310110063#_d79338ff_bd80_4f49_abf4_d7c7940f33fa
is: SBO:0000252
initial concentration: NaN
constant: false
initial amount: NaN
name: DPYD
boundary condition: true
type: Species
is encoded by: hsa:1806
has only substance units: false
is: Q12882

metaR Htx
reactant: MODEL1310110063#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 0 AUTHORS: NOTES:diffusion NJ
fast: false
is described by: ECO:0000000
reversible: true
type: Reaction
is: SBO:0000185
name: H transporter, peroxisome
kinetic law: MODEL1310110063#
product: MODEL1310110063#

metaR r2082
fast: false
type: Reaction
modifier: MODEL1310110063#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
kinetic law: MODEL1310110063#
is: SBO:0000185
is described by: ECO:0000000
reactant: MODEL1310110063#
reversible: true
product: MODEL1310110063#

metaR EX 5mta LPAREN e RPAREN
kinetic law: MODEL1310110063#
reactant: MODEL1310110063#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: Exchange of 5-S-methyl-5-thioadenosine
type: Reaction

metaM tdcrn e
is: HMDB05066
is: SBO:0000247
has only substance units: false
name: myristoyl carnitine
boundary condition: false
constant: false
initial amount: NaN
type: Species
initial concentration: 1.0
notes: FORMULA: C21H41NO4 CHARGE: 0

metaR DGCHOLtx
is described by: ECO:0000000
reversible: true
name: bile acid intracellular transport
reactant: MODEL1310110063#
product: MODEL1310110063#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: NOTES:unknown mechanism, however bile acids need to be secreted out of the cell NJ
type: Reaction
fast: false
kinetic law: MODEL1310110063#
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110063#_5b8df082_d024_4025_b07e_dca0c2cec77b
is: SBO:0000252
constant: false
boundary condition: true
initial amount: NaN
is encoded by: hsa:3418
type: Species
has only substance units: false
initial concentration: NaN
name: IDH2
is: P48735

metaR FORtr
is described by: ECO:0000000
reactant: MODEL1310110063#
is: SBO:0000185
product: MODEL1310110063#
kinetic law: MODEL1310110063#
fast: false
name: FOR transporter, endoplasmic reticulum
type: Reaction
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: NOTES:diffusion NJ

metaR DHDPBMTm
reversible: false
notes: GENE_ASSOCIATION: (51805.1) SUBSYSTEM: Ubiquinone synthesis EC Number: 2.1.1.114 Confidence Level: 4 AUTHORS: PMID:10777520,PMID:1965190,PMID:7380842 NOTES:Used to make Ubiquinone-10 EC 2.1.1.114 IT
is: SBO:0000176
is described by: ECO:0000269
product: MODEL1310110063#
kinetic law: MODEL1310110063#
reactant: MODEL1310110063#
name: dihydroxydecaprenylbenzoate methyltransferase
fast: false
is version of: http://identifiers.org/ec-code/2.1.1.114
modifier: MODEL1310110063#
type: Reaction

metaR PGISr
modifier: MODEL1310110063#
reversible: true
is version of: http://identifiers.org/ec-code/5.3.99.4
product: MODEL1310110063#
type: Reaction
reactant: MODEL1310110063#
is: SBO:0000176
name: Prostaglandin I2 synthase
notes: GENE_ASSOCIATION: (5740.1) SUBSYSTEM: Eicosanoid metabolism EC Number: 5.3.99.4 Confidence Level: 4 AUTHORS: PMID:2120373,PMID:2491846 NOTES:NJ
is described by: ECO:0000134
kinetic law: MODEL1310110063#
fast: false

metaR SEBACACT
kinetic law: MODEL1310110063#
product: MODEL1310110063#
reactant: MODEL1310110063#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: activation of sebacic acidd
type: Reaction

metaM hmgcoa m
is: SBO:0000247
constant: false
initial amount: NaN
boundary condition: false
is: HMDB01375
initial concentration: 1.0
is: CHEBI:15467
has only substance units: false
name: Hydroxymethylglutaryl-CoA
type: Species
notes: FORMULA: C27H39N7O20P3S CHARGE: -5 INCHI: InChI=1S/C27H44N7O20P3S/c1-26(2,21(40)24(41)30-5-4-15(35)29-6-7-58-17(38)9-27(3,42)8-16(36)37)11-51-57(48,49)54-56(46,47)50-10-14-20(53-55(43,44)45)19(39)25(52-14)34-13-33-18-22(28)31-12-32-23(18)34/h12-14,19-21,25,39-40,42H,4-11H2,1-3H3,(H,29,35)(H,30,41)(H,36,37)(H,46,47)(H,48,49)(H2,28,31,32)(H2,43,44,45)/t14-,19-,20-,21+,25-,27+/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00302 EHMN_ABBREVIATION: C00356

http://identifiers.org/biomodels.db/MODEL1310110063#_94f2d18f_817f_4326_8428_d24b5cd2cb58
is: SBO:0000252
has only substance units: false
is encoded by: hsa:594
initial amount: NaN
is: P21953
type: Species
name: BCKDHB
constant: false
initial concentration: NaN
boundary condition: true

metaR r1646
modifier: MODEL1310110063#
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
product: MODEL1310110063#
fast: false
reversible: true
is described by: ECO:0000000
kinetic law: MODEL1310110063#
is: SBO:0000185
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
type: Reaction
reactant: MODEL1310110063#

metaR r1915
type: Reaction
product: MODEL1310110063#
fast: false
is described by: ECO:0000000
reactant: MODEL1310110063#
is: SBO:0000185
kinetic law: MODEL1310110063#
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
modifier: MODEL1310110063#
name: Y+LAT2 Utilized transport
reversible: false

metaM c8crn c
initial amount: NaN
type: Species
boundary condition: false
initial concentration: 1.0
name: octanoyl carnitine
is: HMDB00791
is: C02838
notes: FORMULA: C15H29NO4 CHARGE: 0
has only substance units: false
constant: false
is: SBO:0000247

metaR DSAT
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Sphingolipid metabolism EC Number: Confidence Level: 2 AUTHORS: NOTES:CoA transfer not explicitly in rxn (accounted for in Rtotal rxn -> ARTF) NJ
is: SBO:0000176
reversible: false
reactant: MODEL1310110063#
fast: false
type: Reaction
kinetic law: MODEL1310110063#
product: MODEL1310110063#
name: dihydrosphingosine N-acyltransferase

http://identifiers.org/biomodels.db/MODEL1310110063#_c8e423da_a58d_4aca_8a70_5c52e12ef043
type: Species
boundary condition: true
is: SBO:0000252
is: Q08499
has only substance units: false
is encoded by: hsa:5144
initial amount: NaN
constant: false
initial concentration: NaN
name: PDE4D

metaR GAPD
name: glyceraldehyde-3-phosphate dehydrogenase
kinetic law: MODEL1310110063#
fast: false
reversible: true
reactant: MODEL1310110063#
notes: GENE_ASSOCIATION: (2597.1) or (26330.1) SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: 1.2.1.12 Confidence Level: 0 AUTHORS: PMID:10714828 NOTES:SMP. Same reaction as GAPDH, but localied to spermatids. NOTE: I think "glyceroyl" in this and many other reactions should be "glycerol". There are "glyceroyl" compounds, but I don't think that is what is intended here.
is version of: http://identifiers.org/ec-code/1.2.1.12
modifier: MODEL1310110063#
product: MODEL1310110063#
type: Reaction
is described by: ECO:0000134
is: SBO:0000176

metaM g1m8mpdol U r
constant: false
has only substance units: false
name: alpha-D-Glucosyl-(alpha-D-mannosyl)8-beta-D-mannosyl-diacetylchitobiosyldiphosphodolichol, human uterine homolog
is: CHEBI:59093
initial concentration: 1.0
is: SBO:0000247
notes: FORMULA: C1785H2940N20O670P20 CHARGE: -20
type: Species
boundary condition: false
initial amount: NaN

metaR GLNt4
notes: GENE_ASSOCIATION: (81539.1) or (11254.1) or (54407.1) or (55089.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10747860,PMID:10891391,PMID:10930503,PMID:11325958,PMID:11342143,PMID:11414754 NOTES:SAB
modifier: MODEL1310110063#
type: Reaction
name: L-glutamine reversible transport via sodium symport
product: MODEL1310110063#
kinetic law: MODEL1310110063#
is described by: ECO:0000269
reversible: false
fast: false
reactant: MODEL1310110063#
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110063#_166c6436_0fe0_43eb_bb1f_350658d0f3cd
is: SBO:0000252
initial concentration: NaN
has only substance units: false
initial amount: NaN
name: LCT
boundary condition: true
type: Species
is: P09848
constant: false
is encoded by: hsa:3938

metaR UDPtl
kinetic law: MODEL1310110063#
reversible: true
product: MODEL1310110063#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 1 AUTHORS: NOTES:unknown mechanism for transport - not known if it is energy dependent or not, recycling and IC transport is important to get it to other areas of the cell (e.g. plasma membrane) - translocators have been found for ER and Golgi - none found for lysosome yet so non-mechanistic transporter added - in future this will need to be revised _when_ a translocator is found NJ
reactant: MODEL1310110063#
fast: false
name: udp intracellular transport
type: Reaction
is: SBO:0000185

metaM pristanal c
has only substance units: false
is: CHEBI:49189
notes: FORMULA: C19H38O CHARGE: 0 INCHI: InChI=1S/C19H38O/c1-16(2)9-6-10-17(3)11-7-12-18(4)13-8-14-19(5)15-20/h15-19H,6-14H2,1-5H3
initial amount: NaN
type: Species
boundary condition: false
constant: false
is: SBO:0000247
initial concentration: 1.0
is: HMDB01958
name: pristanal

metaR TTDCAFATPc
kinetic law: MODEL1310110063#
product: MODEL1310110063#
reactant: MODEL1310110063#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: uptake of uptake of Hexadecanoate by the enterocytes by the enterocytes
type: Reaction

metaR EX pheme LPAREN e RPAREN
kinetic law: MODEL1310110063#
reactant: MODEL1310110063#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for heme
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110063#_12f8621e_6d92_4347_afb1_d1209caea6cd
is: SBO:0000252
initial amount: NaN
is: O94777
type: Species
initial concentration: NaN
has only substance units: false
boundary condition: true
constant: false
is encoded by: hsa:8818
name: DPM2

http://identifiers.org/biomodels.db/MODEL1310110063#_59222cd1_532d_4a3a_9830_ca38ea200d63
name: PRPS1L1
is encoded by: hsa:221823
has only substance units: false
type: Species
initial concentration: NaN
boundary condition: true
constant: false
is: SBO:0000252
is: P21108
initial amount: NaN

metaM thcholstoic x
initial amount: NaN
is: CHEBI:18402
is: SBO:0000247
initial concentration: 1.0
boundary condition: false
name: 3alpha,7alpha,12alpha-Trihydroxy-5beta-cholestanoate
type: Species
constant: false
is: HMDB03873
notes: FORMULA: C27H45O5 CHARGE: -1 INCHI: InChI=1S/C27H46O5/c1-15(6-5-7-16(2)25(31)32)19-8-9-20-24-21(14-23(30)27(19,20)4)26(3)11-10-18(28)12-17(26)13-22(24)29/h15-24,28-30H,5-14H2,1-4H3,(H,31,32)/t15-,16?,17+,18-,19-,20+,21+,22-,23+,24+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01340 EHMN_ABBREVIATION: C04722
has only substance units: false

metaR CBASPte
reactant: MODEL1310110063#
type: Reaction
reversible: true
product: MODEL1310110063#
is described by: ECO:0000134
fast: false
kinetic law: MODEL1310110063#
name: Transport of N-carbamoyl-L-aspartate
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:

metaM odecoa c
boundary condition: false
notes: FORMULA: C39H64N7O17P3S CHARGE: -4
initial concentration: 1.0
is: HMDB01322
initial amount: NaN
constant: false
name: Octadecenoyl-CoA (n-C18:1CoA)
is: CHEBI:3793
is: SBO:0000247
type: Species
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110063#_46c6d837_d573_4d86_98a2_c6d49d92b0de
initial concentration: NaN
is encoded by: hsa:AL048840
has only substance units: false
constant: false
name: _AL048840_1_c
type: Species
is: SBO:0000252
initial amount: NaN
boundary condition: true

metaR Htr
product: MODEL1310110063#
is: SBO:0000185
name: H transporter, endoplasmic reticulum
reactant: MODEL1310110063#
is described by: ECO:0000000
kinetic law: MODEL1310110063#
fast: false
reversible: true
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: NOTES:diffusion NJ

http://identifiers.org/biomodels.db/MODEL1310110063#_d3ca62dc_e438_4fe3_9200_0c11940ac354
initial concentration: NaN
boundary condition: true
is: SBO:0000252
type: Species
name: GALNT12
has only substance units: false
is: Q8IXK2
initial amount: NaN
constant: false
is encoded by: hsa:79695

http://identifiers.org/biomodels.db/MODEL1310110063#_1703b381_fe7a_431b_9e8a_982862c983e0
boundary condition: true
type: Species
constant: false
initial concentration: NaN
is encoded by: hsa:10195
name: ALG3
has only substance units: false
is: SBO:0000252
initial amount: NaN

metaM cspg a l
type: Species
is: CHEBI:36005
has only substance units: false
is: HMDB02183
initial amount: NaN
notes: FORMULA: C45H66N2O45S3X CHARGE: -5
constant: false
initial concentration: 1.0
name: chondroitin sulfate A (GalNAc4S-GlcA) proteoglycan
boundary condition: false
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110063#_bc88ca9f_f59f_4a9e_9202_76bcfd130774
is encoded by: hsa:3098
is: B3KXY9
initial amount: NaN
has only substance units: false
initial concentration: NaN
type: Species
constant: false
boundary condition: true
name: HK1
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110063#_cf8ed049_bd80_42e3_91c8_4188ac5ff143
is encoded by: hsa:2879
initial amount: NaN
initial concentration: NaN
has only substance units: false
type: Species
boundary condition: true
is: SBO:0000252
name: GPX4
constant: false
is: P36969

metaR FACOAL244 1
modifier: MODEL1310110063#
reactant: MODEL1310110063#
notes: GENE_ASSOCIATION: (2180.1) SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 4 AUTHORS: PMID:15292367 NOTES:NJ
reversible: true
is: SBO:0000176
name: fatty-acid--CoA ligase
is described by: ECO:0000000
fast: false
product: MODEL1310110063#
type: Reaction
kinetic law: MODEL1310110063#
is version of: http://identifiers.org/ec-code/6.2.1.3

metaR UDPGALtg
fast: false
is: SBO:0000185
reversible: true
kinetic law: MODEL1310110063#
is described by: ECO:0000269
product: MODEL1310110063#
modifier: MODEL1310110063#
type: Reaction
name: UDP-Gal Golgi transport via CMP antiport
notes: GENE_ASSOCIATION: (7355.1) SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 4 AUTHORS: PMID:11784306,PMID:8889805,PMID:9010752,PMID:9399569,PMID:9562625 NOTES:NCD
reactant: MODEL1310110063#

metaR RETNt
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:8630327 NOTES:IT
reactant: MODEL1310110063#
reversible: true
is: SBO:0000185
kinetic law: MODEL1310110063#
name: retinoic acid transport
fast: false
type: Reaction
is described by: ECO:0000000
product: MODEL1310110063#

metaR HS1ly
is version of: http://identifiers.org/ec-code/3.10.1.1
name: heparan-N-sulfatase, lysosomal
reactant: MODEL1310110063#
is: SBO:0000176
product: MODEL1310110063#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (6448.1) SUBSYSTEM: Heparan sulfate degradation EC Number: 3.10.1.1 Confidence Level: 4 AUTHORS: PMID:7493035,PMID:8993162,PMID:9405287 NOTES:NCD
type: Reaction
modifier: MODEL1310110063#
fast: false
reversible: false
kinetic law: MODEL1310110063#

metaM c226crn m
is: HMDB06510
is: SBO:0000247
notes: FORMULA: C29H45NO4 CHARGE: 0 INCHI: InChI=1/C29H45NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-24-29(33)34-27(25-28(31)32)26-30(2,3)4/h6-7,9-10,12-13,15-16,18-19,21-22,27H,5,8,11,14,17,20,23-26H2,1-4H3/b7-6+,10-9+,13-12+,16-15+,19-18+,22-21+
has only substance units: false
is: http://identifiers.org/pubchem.compound/127055
initial concentration: 1.0
type: Species
initial amount: NaN
boundary condition: false
constant: false
name: cervonyl carnitine

metaM nadph c
notes: FORMULA: C21H26N7O17P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00015 EHMN_ABBREVIATION: C00005
is: SBO:0000247
has only substance units: false
name: Nicotinamide adenine dinucleotide phosphate - reduced
constant: false
boundary condition: false
is: CHEBI:57783
is: HMDB00221
initial concentration: 1.0
is: C00005
initial amount: NaN
type: Species

metaR DLNLCGCRNt
reactant: MODEL1310110063#
type: Reaction
is: SBO:0000185
product: MODEL1310110063#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (788.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: NOTES:NJ
name: transport into the mitochondria (carnitine)
reversible: false
fast: false
modifier: MODEL1310110063#
kinetic law: MODEL1310110063#

http://identifiers.org/biomodels.db/MODEL1310110063#_5521eea8_d337_4a65_90c4_93c6e3cdcb69
initial concentration: NaN
initial amount: NaN
constant: false
has only substance units: false
name: GCSH
is encoded by: hsa:2653
type: Species
is: SBO:0000252
is: P23434
boundary condition: true

metaR EX pect LPAREN e RPAREN
kinetic law: MODEL1310110063#
reactant: MODEL1310110063#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for pectins
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110063#_12dc1f25_6079_496c_b7d1_86503f589779
initial amount: NaN
type: Species
is encoded by: hsa:79717
boundary condition: true
is: Q9HAB8
has only substance units: false
is: SBO:0000252
name: PPCS
constant: false
initial concentration: NaN

metaR UGCG
fast: false
is: SBO:0000176
modifier: MODEL1310110063#
reactant: MODEL1310110063#
type: Reaction
reversible: false
name: Ceramide glucosyltransferase
is version of: http://identifiers.org/ec-code/2.4.1.80
notes: GENE_ASSOCIATION: (7357.1) SUBSYSTEM: Sphingolipid metabolism EC Number: 2.4.1.80 Confidence Level: 4 AUTHORS: PMID:8643456 NOTES:NJ
kinetic law: MODEL1310110063#
product: MODEL1310110063#
is described by: ECO:0000000

metaR EX ppa LPAREN e RPAREN
kinetic law: MODEL1310110063#
reactant: MODEL1310110063#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Propionate exchange
type: Reaction

metaM methf c
is: SBO:0000247
constant: false
initial concentration: 1.0
has only substance units: false
type: Species
notes: FORMULA: C20H20N7O6 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00360 EHMN_ABBREVIATION: C00445
is: C00445
initial amount: NaN
name: 5,10-Methenyltetrahydrofolate
is: CHEBI:57455
is: HMDB01354
boundary condition: false

metaM lac D e
notes: FORMULA: C3H5O3 CHARGE: -1 INCHI: InChI=1S/C3H6O3/c1-2(4)3(5)6/h2,4H,1H3,(H,5,6)/p-1/t2-/m1/s1
type: Species
is: CHEBI:16004
initial concentration: 1.0
name: (R)-lactate
constant: false
is: SBO:0000247
boundary condition: false
initial amount: NaN
has only substance units: false
is: HMDB01311

metaM atp e
constant: false
name: ATP(4-)
is: CHEBI:57299
is: HMDB00538
is: C00002
has only substance units: false
initial concentration: 1.0
type: Species
boundary condition: false
is: SBO:0000247
initial amount: NaN

metaM anth e
is: CHEBI:16567
has only substance units: false
notes: FORMULA: C7H6NO2 CHARGE: -1 INCHI: InChI=1S/C7H7NO2/c8-6-4-2-1-3-5(6)7(9)10/h1-4H,8H2,(H,9,10)/p-1
name: anthranilate
initial concentration: 1.0
initial amount: NaN
type: Species
boundary condition: false
is: HMDB01123
is: SBO:0000247
constant: false

metaM tcynt e
boundary condition: false
initial amount: NaN
notes: FORMULA: CNS CHARGE: -1 INCHI: InChI=1S/CHNS/c2-1-3/h3H/p-1 EHMN_ABBREVIATION: C01755
is: CHEBI:18022
type: Species
constant: false
name: thiocyanate
is: SBO:0000247
has only substance units: false
initial concentration: 1.0
is: HMDB01453

metaM CE5125 x
notes: FORMULA: C40H68N7O17P3S CHARGE: -4 INCHI: InChI=1/C40H72N7O17P3S/c1-25(2)11-8-12-26(3)13-9-14-27(4)15-10-16-28(5)39(52)68-20-19-42-30(48)17-18-43-37(51)34(50)40(6,7)22-61-67(58,59)64-66(56,57)60-21-29-33(63-65(53,54)55)32(49)38(62-29)47-24-46-31-35(41)44-23-45-36(31)47/h23-29,32-34,38,49-50H,8-22H2,1-7H3,(H,42,48)(H,43,51)(H,56,57)(H,58,59)(H2,41,44,45)(H2,53,54,55)/p-4/t26-,27-,28-,29-,32+,33+,34u,38-/m0/s1 EHMN_ABBREVIATION: CE5125
name: (2S)-pristanoyl-CoA
has only substance units: false
is: CHEBI:15748
boundary condition: false
type: Species
constant: false
is: SBO:0000247
is: HMDB00127
initial amount: NaN
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110063#_e91ae7f2_dbef_40e5_90f0_d23cad1c2ebf
has only substance units: false
constant: false
boundary condition: true
is encoded by: hsa:518
initial amount: NaN
is: P48201
name: ATP5G3
is: SBO:0000252
type: Species
initial concentration: NaN

metaR r1649
is: SBO:0000185
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
kinetic law: MODEL1310110063#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reversible: true
fast: false
reactant: MODEL1310110063#
is described by: ECO:0000000
product: MODEL1310110063#
type: Reaction
modifier: MODEL1310110063#

metaR EX cbasp LPAREN e RPAREN
kinetic law: MODEL1310110063#
reactant: MODEL1310110063#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: Exchange of N-carbamoyl-L-aspartate
type: Reaction

metaM lcts e
constant: false
has only substance units: false
initial amount: NaN
is: CHEBI:17716
is: C00243
type: Species
is: HMDB00186
initial concentration: 1.0
boundary condition: false
notes: FORMULA: C12H22O11 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00220 EHMN_ABBREVIATION: C00243
name: Lactose
is: SBO:0000247

metaM HC01496 m
is: SBO:0000247
initial concentration: 1.0
initial amount: NaN
boundary condition: false
notes: FORMULA: C6H8NO5 CHARGE: -1 INCHI: InChI=1S/C6H9NO5/c7-5(6(11)12)3(8)1-2-4(9)10/h5H,1-2,7H2,(H,9,10)(H,11,12) EHMN_ABBREVIATION: C05520
name: 2-Amino-3-oxoadipate
type: Species
has only substance units: false
constant: false
is: CHEBI:28095

metaR S6TASE12ly
name: N-acetylglucosamine-6-sulfatase, lysosomal
product: MODEL1310110063#
modifier: MODEL1310110063#
is described by: ECO:0000000
kinetic law: MODEL1310110063#
is: SBO:0000176
fast: false
notes: GENE_ASSOCIATION: (2799.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.1.6.14 Confidence Level: 4 AUTHORS: PMID:3196333,PMID:3689314,PMID:3689315 NOTES:NCD
reversible: true
reactant: MODEL1310110063#
type: Reaction
is version of: http://identifiers.org/ec-code/3.1.6.14

metaM sarcs c
notes: FORMULA: C3H7NO2 CHARGE: 0
is: C00213
constant: false
is: SBO:0000247
initial concentration: 1.0
is: HMDB00271
name: Sarcosine
is: CHEBI:3513
has only substance units: false
boundary condition: false
initial amount: NaN
type: Species

metaR CITRtm
name: citrulline mitochondrial transport via proton antiport
notes: GENE_ASSOCIATION: (83884.1) or (10166.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172 NOTES:TDV
kinetic law: MODEL1310110063#
reactant: MODEL1310110063#
fast: false
product: MODEL1310110063#
type: Reaction
reversible: true
is: SBO:0000185
is described by: ECO:0000269
modifier: MODEL1310110063#

metaR FAOXC225m
kinetic law: MODEL1310110063#
product: MODEL1310110063#
reactant: MODEL1310110063#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: isomerization(C22:5)m
type: Reaction

metaR SCP21cx
kinetic law: MODEL1310110063#
product: MODEL1310110063#
reactant: MODEL1310110063#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of phytanoylcoa from cytosol to peroxisomes.
type: Reaction

metaM fum c
is: HMDB00134
initial amount: NaN
boundary condition: false
has only substance units: false
name: Fumarate
initial concentration: 1.0
type: Species
is: SBO:0000247
is: CHEBI:29806
is: C00122
constant: false
notes: FORMULA: C4H2O4 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00120 EHMN_ABBREVIATION: C00122

metaM cs a deg3 l
notes: FORMULA: C31H48NO32S2 CHARGE: -3
is: CHEBI:15748
has only substance units: false
is: SBO:0000247
boundary condition: false
initial amount: NaN
is: HMDB00127
type: Species
name: chondroitin sulfate A (GalNAc4S-GlcA), degradation product 3
initial concentration: 1.0
constant: false

metaR FAOXC1811603m
is version of: http://identifiers.org/ec-code/1.3.8.1
fast: false
is: SBO:0000176
is described by: ECO:0000269
name: Beta oxidation fatty acid
product: MODEL1310110063#
is version of: http://identifiers.org/ec-code/1.3.99.3
type: Reaction
reactant: MODEL1310110063#
reversible: false
notes: GENE_ASSOCIATION: (34.1) or (35.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.74 Confidence Level: 4 AUTHORS: NOTES:_5 rounds of beta ox, 1 loss of degree of unsat -> 4 fad oxidized c18:1 -> c8:0 4 step FAO lumped for 2 rounds also includes EC 1.1.1.35, 1.1.1.211, 1.3.3.6, 4.2.1.17, 4.2.1.74 NJ
kinetic law: MODEL1310110063#
modifier: MODEL1310110063#

http://identifiers.org/biomodels.db/MODEL1310110063#_b7b3c775_87e7_4a6b_84ec_b8f311eed922
initial concentration: NaN
is encoded by: hsa:8790
name: FPGT
constant: false
is: O14772
type: Species
initial amount: NaN
boundary condition: true
is: SBO:0000252
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110063#_6670d903_07ec_4a76_a779_98df3899d270
has only substance units: false
initial concentration: NaN
constant: false
boundary condition: true
is: Q9ULD0
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:55753
type: Species
name: OGDHL

http://identifiers.org/biomodels.db/MODEL1310110063#_24a0f5c8_397e_49f9_a085_a76d8f7403d0
is: B3KVA3
is: SBO:0000252
initial concentration: NaN
initial amount: NaN
boundary condition: true
constant: false
name: RDH13
is encoded by: hsa:112724
has only substance units: false
type: Species

metaM so4 e
is: CHEBI:16189
initial amount: NaN
is: HMDB01448
name: sulfate
notes: FORMULA: O4S CHARGE: -2 INCHI: InChI=1S/H2O4S/c1-5(2,3)4/h(H2,1,2,3,4)/p-2 HEPATONET_1.0_ABBREVIATION: HC00062 EHMN_ABBREVIATION: C00059
is: SBO:0000247
initial concentration: 1.0
constant: false
type: Species
has only substance units: false
boundary condition: false

metaM mi14p c
is: CHEBI:58282
is: SBO:0000247
constant: false
is: HMDB00968
has only substance units: false
name: (1R,2R,3R,4R,5R,6S)-2,3,5,6-tetrahydroxy-4-(phosphonatooxy)cyclohexyl phosphate
type: Species
initial amount: NaN
boundary condition: false
initial concentration: 1.0
notes: FORMULA: C6H10O12P2 CHARGE: -4 INCHI: InChI=1S/C6H14O12P2/c7-1-2(8)6(18-20(14,15)16)4(10)3(9)5(1)17-19(11,12)13/h1-10H,(H2,11,12,13)(H2,14,15,16)/p-4/t1-,2-,3-,4+,5+,6+/m1/s1 EHMN_ABBREVIATION: C01220

metaR T4HCINNMFM
is: SBO:0000176
reactant: MODEL1310110063#
is described by: ECO:0000000
fast: false
name: 4-hydroxycinnamate formation
type: Reaction
kinetic law: MODEL1310110063#
reversible: false
product: MODEL1310110063#
notes: GENE_ASSOCIATION: SUBSYSTEM: Ubiquinone synthesis EC Number: Confidence Level: 2 AUTHORS: PMID:11583838,PMID:12232327 NOTES:IT reaction involved in formation of 4-hydroxybenzoate from tyrosine.

metaM 3hpcoa m
is: HMDB06807
initial concentration: 1.0
boundary condition: false
has only substance units: false
constant: false
name: 3-hydroxypropanoyl-CoA(4-)
notes: FORMULA: C24H36N7O18P3S CHARGE: -4 INCHI: InChI=1S/C24H40N7O18P3S/c1-24(2,19(36)22(37)27-5-3-14(33)26-6-8-53-15(34)4-7-32)10-46-52(43,44)49-51(41,42)45-9-13-18(48-50(38,39)40)17(35)23(47-13)31-12-30-16-20(25)28-11-29-21(16)31/h11-13,17-19,23,32,35-36H,3-10H2,1-2H3,(H,26,33)(H,27,37)(H,41,42)(H,43,44)(H2,25,28,29)(H2,38,39,40)/p-4/t13-,17-,18-,19+,23-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01557 EHMN_ABBREVIATION: C05668
type: Species
is: CHEBI:58528
is: SBO:0000247
initial amount: NaN

metaR LGTHL
name: lactoylglutathione lyase
is version of: http://identifiers.org/ec-code/4.4.1.5
is: SBO:0000176
fast: false
type: Reaction
kinetic law: MODEL1310110063#
reactant: MODEL1310110063#
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (2739.1) SUBSYSTEM: Pyruvate metabolism EC Number: 4.4.1.5 Confidence Level: 4 AUTHORS: PMID:7684374,PMID:8449929 NOTES:IF
modifier: MODEL1310110063#
reversible: false
product: MODEL1310110063#

metaM anth c
name: anthranilate
is: HMDB01123
boundary condition: false
initial concentration: 1.0
initial amount: NaN
is: CHEBI:16567
constant: false
notes: FORMULA: C7H6NO2 CHARGE: -1 INCHI: InChI=1S/C7H7NO2/c8-6-4-2-1-3-5(6)7(9)10/h1-4H,8H2,(H,9,10)/p-1 HEPATONET_1.0_ABBREVIATION: HC00107 EHMN_ABBREVIATION: C00108
has only substance units: false
is: SBO:0000247
type: Species

metaR URIt
notes: GENE_ASSOCIATION: (3177.1) or (2030.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10722669,PMID:12838422 NOTES:IT
is: SBO:0000185
fast: false
type: Reaction
is described by: ECO:0000269
name: uridine facilated transport in cytosol
reversible: true
kinetic law: MODEL1310110063#
product: MODEL1310110063#
modifier: MODEL1310110063#
reactant: MODEL1310110063#

metaR LEULEULAPc
kinetic law: MODEL1310110063#
product: MODEL1310110063#
reactant: MODEL1310110063#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: hydrolysis of Leucylleucine in the small intestine for cellular uptake
type: Reaction

metaM o2 x
constant: false
name: O2
initial amount: NaN
has only substance units: false
boundary condition: false
type: Species
is: C00007
is: CHEBI:15379
initial concentration: 1.0
notes: FORMULA: O2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00017 EHMN_ABBREVIATION: C00007
is: SBO:0000247
is: HMDB01377

metaM xyl D c
notes: FORMULA: C5H10O5 CHARGE: 0 INCHI: InChI=1S/C5H10O5/c6-1-3(8)5(10)4(9)2-7/h1,3-5,7-10H,2H2/t3-,4+,5+/m0/s1
initial concentration: 1.0
boundary condition: false
name: aldehydo-D-xylose
is: CHEBI:15936
type: Species
constant: false
is: SBO:0000247
initial amount: NaN
has only substance units: false

metaR EX fru LPAREN e RPAREN
kinetic law: MODEL1310110063#
reactant: MODEL1310110063#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for D-Fructose
type: Reaction

metaR 34DHOXPEGOX
name: 3,4-Dihydroxyphenylethyleneglycol:NAD+ oxidoreductase
reversible: true
is version of: http://identifiers.org/ec-code/1.1.1.1
product: MODEL1310110063#
notes: GENE_ASSOCIATION: (130.1) or (127.1) or (125.1 and 124.1) or (131.1) or (126.1 and 124.1) or (128.1) or (137872.1) or (125.1 and 126.1) SUBSYSTEM: Tyrosine metabolism EC Number: 1.1.1.1 Confidence Level: 4 AUTHORS: PMID:3466164 NOTES:SAB
reactant: MODEL1310110063#
kinetic law: MODEL1310110063#
fast: false
modifier: MODEL1310110063#
is version of: http://identifiers.org/ec-code/1.1.99.24
type: Reaction
is: SBO:0000176
is described by: ECO:0000269

metaR EX asp L LPAREN e RPAREN
kinetic law: MODEL1310110063#
reactant: MODEL1310110063#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: L-Aspartate exchange
type: Reaction

metaR FAOXC140
notes: GENE_ASSOCIATION: (35.1) or (34.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.99.3 Confidence Level: 4 AUTHORS: PMID:2565344 NOTES:TV Other enzymes: 1.3.3.6, 4.2.1.74, 4.2.1.17, 1.1.1.35, 1.1.1.211
is described by: ECO:0000269
reversible: false
fast: false
product: MODEL1310110063#
reactant: MODEL1310110063#
is version of: http://identifiers.org/ec-code/1.3.99.3
name: Beta oxidation of long chain fatty acid
type: Reaction
modifier: MODEL1310110063#
kinetic law: MODEL1310110063#
is version of: http://identifiers.org/ec-code/1.3.8.1
is: SBO:0000176

metaR EX btn LPAREN e RPAREN
kinetic law: MODEL1310110063#
reactant: MODEL1310110063#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Biotin exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110063#_0d619ca8_b913_4f11_b4d3_46b17e052e14
is: SBO:0000252
is encoded by: hsa:BE966236
has only substance units: false
name: _BE966236_1_c
constant: false
initial amount: NaN
initial concentration: NaN
type: Species
boundary condition: true

metaR FAOXC150m
product: MODEL1310110063#
type: Reaction
modifier: MODEL1310110063#
is described by: ECO:0000269
kinetic law: MODEL1310110063#
fast: false
is: SBO:0000176
name: Beta oxidation of long chain fatty acid (odd chain)
is version of: http://identifiers.org/ec-code/1.3.99.3
reactant: MODEL1310110063#
notes: GENE_ASSOCIATION: (35.1) or (34.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.99.3 Confidence Level: 4 AUTHORS: PMID:2565344 NOTES:by extension from even chain lumped FAO - should double-check stoich in future NJ
reversible: false
is version of: http://identifiers.org/ec-code/1.3.8.1

http://identifiers.org/biomodels.db/MODEL1310110063#_33b1214a_b583_4f1f_a577_bca71054f97a
is: P43166
initial amount: NaN
is encoded by: hsa:766
is: SBO:0000252
boundary condition: true
type: Species
name: CA7
has only substance units: false
initial concentration: NaN
constant: false

metaR EX ile L LPAREN e RPAREN
kinetic law: MODEL1310110063#
reactant: MODEL1310110063#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: L-Isoleucine exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110063#_d573a2d9_a67e_4363_9489_20bc671b70ba
is encoded by: hsa:8527
has only substance units: false
is: SBO:0000252
type: Species
name: DGKD
boundary condition: true
initial concentration: NaN
constant: false
is: Q16760
initial amount: NaN

metaM sarcs e
type: Species
notes: FORMULA: C3H7NO2 CHARGE: 0 INCHI: InChI=1S/C3H7NO2/c1-4-2-3(5)6/h4H,2H2,1H3,(H,5,6) HEPATONET_1.0_ABBREVIATION: HC00197 EHMN_ABBREVIATION: C00213
initial amount: NaN
name: sarcosine
is: HMDB00271
constant: false
is: CHEBI:15611
boundary condition: false
initial concentration: 1.0
has only substance units: false
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110063#_4195bba8_250f_402b_a5d8_422495aff1a8
name: ACAD11
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:84129
constant: false
type: Species
has only substance units: false
is: Q709F0
initial concentration: NaN
boundary condition: true

metaR GHMT2rm
notes: GENE_ASSOCIATION: (6472.1) SUBSYSTEM: Glycine, serine, alanine and threonine metabolism EC Number: 2.1.2.1 Confidence Level: 4 AUTHORS: PMID:8505317,PMID:8611185,PMID:9038835 NOTES:NCD
reactant: MODEL1310110063#
modifier: MODEL1310110063#
reversible: true
is: SBO:0000176
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/2.1.2.1
fast: false
product: MODEL1310110063#
name: glycine hydroxymethyltransferase, reversible, mitochondrial
type: Reaction
kinetic law: MODEL1310110063#

metaM 5mthf e
constant: false
is: CHEBI:3729
has only substance units: false
is: SBO:0000247
initial concentration: 1.0
type: Species
is: HMDB01396
initial amount: NaN
is: C00440
boundary condition: false
name: 5-Methyltetrahydrofolate
notes: FORMULA: C20H24N7O6 CHARGE: -1

metaR ENGASE3ly
name: endo-beta-N-acetylglucosaminidase, lysosomal
notes: GENE_ASSOCIATION: SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.96 Confidence Level: 0 AUTHORS: NOTES:NCD
kinetic law: MODEL1310110063#
is: SBO:0000176
reversible: false
product: MODEL1310110063#
type: Reaction
is described by: ECO:0000000
reactant: MODEL1310110063#
fast: false

metaR PPA
reactant: MODEL1310110063#
type: Reaction
is version of: http://identifiers.org/ec-code/3.6.1.1
fast: false
is: SBO:0000176
notes: GENE_ASSOCIATION: (5464.1) SUBSYSTEM: Oxidative phosphorylation EC Number: 3.6.1.1 Confidence Level: 4 AUTHORS: PMID:10542310,PMID:15533045 NOTES:
is described by: ECO:0000269
kinetic law: MODEL1310110063#
name: inorganic diphosphatase
product: MODEL1310110063#
reversible: false
modifier: MODEL1310110063#

http://identifiers.org/biomodels.db/MODEL1310110063#_d760e9d5_23a2_4030_a736_49d933dda0ce
constant: false
is: SBO:0000252
name: GLUD1
initial concentration: NaN
is encoded by: hsa:2746
initial amount: NaN
boundary condition: true
type: Species
is: E9KL48
has only substance units: false

metaR EX tymsf LPAREN e RPAREN
kinetic law: MODEL1310110063#
reactant: MODEL1310110063#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Tyramine O-sulfate exchange
type: Reaction

metaR q10tm
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: NOTES:
is described by: ECO:0000134
reversible: true
is: SBO:0000185
reactant: MODEL1310110063#
kinetic law: MODEL1310110063#
fast: false
name: transport of ubiquinone into mitochondria
product: MODEL1310110063#

http://identifiers.org/biomodels.db/MODEL1310110063#_53358f28_ac5d_454b_a087_ecf742aa5f55
is: P83881
type: Species
is encoded by: hsa:6173
is: SBO:0000252
boundary condition: true
constant: false
initial concentration: NaN
has only substance units: false
name: RPL36A
initial amount: NaN

metaR HMGCOASim
kinetic law: MODEL1310110063#
reversible: false
notes: GENE_ASSOCIATION: (3158.1) SUBSYSTEM: Cholesterol metabolism EC Number: 4.1.3.5 Confidence Level: 4 AUTHORS: PMID:7893153 NOTES:NCD New assignment: EC-2.3.3.10 EC-4.1.3.5 (created 1961, deleted 2002). Enzyme Commission mitochondrial enzyme NJ Made irreversible to match KEGG data for S. aureus
is described by: ECO:0000269
is: SBO:0000176
reactant: MODEL1310110063#
product: MODEL1310110063#
is version of: http://identifiers.org/ec-code/2.3.3.10
modifier: MODEL1310110063#
fast: false
type: Reaction
name: Hydroxymethylglutaryl CoA synthase (ir)

metaM ksi deg20 l
boundary condition: false
has only substance units: false
name: keratan sulfate I, degradation product 20
initial amount: NaN
is: SBO:0000247
is: HMDB00143
notes: FORMULA: C138H223N9O119S6 CHARGE: -6
initial concentration: 1.0
constant: false
is: CHEBI:12936
type: Species

metaM xyl D e
has only substance units: false
notes: FORMULA: C5H10O5 CHARGE: 0 INCHI: InChI=1S/C5H10O5/c6-1-3(8)5(10)4(9)2-7/h1,3-5,7-10H,2H2/t3-,4+,5+/m0/s1
initial concentration: 1.0
boundary condition: false
is: CHEBI:15936
constant: false
name: aldehydo-D-xylose
type: Species
is: SBO:0000247
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110063#_786171ab_e007_4f1b_b18c_12bdeb198454
initial concentration: NaN
constant: false
type: Species
is: SBO:0000252
name: PIGF
initial amount: NaN
is: Q6IB04
boundary condition: true
is encoded by: hsa:5281
has only substance units: false

metaM hmgcoa c
constant: false
has only substance units: false
initial amount: NaN
is: SBO:0000247
is: CHEBI:15467
name: Hydroxymethylglutaryl-CoA
is: HMDB01375
type: Species
initial concentration: 1.0
boundary condition: false
notes: FORMULA: C27H39N7O20P3S CHARGE: -5 INCHI: InChI=1S/C27H44N7O20P3S/c1-26(2,21(40)24(41)30-5-4-15(35)29-6-7-58-17(38)9-27(3,42)8-16(36)37)11-51-57(48,49)54-56(46,47)50-10-14-20(53-55(43,44)45)19(39)25(52-14)34-13-33-18-22(28)31-12-32-23(18)34/h12-14,19-21,25,39-40,42H,4-11H2,1-3H3,(H,29,35)(H,30,41)(H,36,37)(H,46,47)(H,48,49)(H2,28,31,32)(H2,43,44,45)/t14-,19-,20-,21+,25-,27+/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00302 EHMN_ABBREVIATION: C00356

http://identifiers.org/biomodels.db/MODEL1310110063#_3aa8bef0_0a84_4cbd_83de_a5c2f86da23f
is: SBO:0000252
name: PIGO
constant: false
boundary condition: true
type: Species
is encoded by: hsa:84720
initial concentration: NaN
initial amount: NaN
has only substance units: false

metaR NACHEX21ly
kinetic law: MODEL1310110063#
is version of: http://identifiers.org/ec-code/3.2.1.52
reversible: false
fast: false
notes: GENE_ASSOCIATION: (3074.1) or (3073.1) or (3073.1 and 3074.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.52 Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12706724,PMID:8993162 NOTES:NCD
is: SBO:0000176
is described by: ECO:0000000
reactant: MODEL1310110063#
type: Reaction
name: beta-N-acetylhexosaminidase, lysosomal
product: MODEL1310110063#
modifier: MODEL1310110063#

metaM ksii core4 pre3 g
has only substance units: false
is: CHEBI:58053
constant: false
type: Species
initial amount: NaN
boundary condition: false
name: keratan sulfate II biosynthesis, precursor 3
is: SBO:0000247
initial concentration: 1.0
is: C00130
is: HMDB00175
notes: FORMULA: C55H89N5O38X CHARGE: -1

metaR PROt4 2 r
fast: false
reactant: MODEL1310110063#
reversible: true
notes: GENE_ASSOCIATION: (6534.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12719981 NOTES:SAB
name: Proline transport (sodium symport) (2:1)
kinetic law: MODEL1310110063#
product: MODEL1310110063#
modifier: MODEL1310110063#
is described by: ECO:0000006
is: SBO:0000185
type: Reaction

metaR r2360
is: SBO:0000185
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
fast: false
product: MODEL1310110063#
kinetic law: MODEL1310110063#
name: Organic anion transporter 5 Utilized transport
reactant: MODEL1310110063#
is described by: ECO:0000000
reversible: true

metaR EX c4crn
kinetic law: MODEL1310110063#
reactant: MODEL1310110063#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for butyryl carnitine
type: Reaction

metaM bilirub r
initial concentration: 1.0
name: bilirubin(2-)
constant: false
boundary condition: false
is: HMDB00054
is: CHEBI:57977
initial amount: NaN
type: Species
is: SBO:0000247
has only substance units: false
notes: FORMULA: C33H34N4O6 CHARGE: -2 INCHI: InChI=1S/C33H36N4O6/c1-7-20-19(6)32(42)37-27(20)14-25-18(5)23(10-12-31(40)41)29(35-25)15-28-22(9-11-30(38)39)17(4)24(34-28)13-26-16(3)21(8-2)33(43)36-26/h7-8,13-14,34-35H,1-2,9-12,15H2,3-6H3,(H,36,43)(H,37,42)(H,38,39)(H,40,41)/p-2/b26-13-,27-14- HEPATONET_1.0_ABBREVIATION: HC00385 EHMN_ABBREVIATION: C00486

metaM ksii core2 pre5 g
is: SBO:0000247
is: C00130
initial concentration: 1.0
name: keratan sulfate II biosynthesis, precursor 5
notes: FORMULA: C61H99N5O43X CHARGE: -1
type: Species
is: CHEBI:58053
initial amount: NaN
boundary condition: false
has only substance units: false
constant: false
is: HMDB00175

metaM thcholstoic r
initial concentration: 1.0
is: CHEBI:18402
notes: FORMULA: C27H45O5 CHARGE: -1 INCHI: InChI=1S/C27H46O5/c1-15(6-5-7-16(2)25(31)32)19-8-9-20-24-21(14-23(30)27(19,20)4)26(3)11-10-18(28)12-17(26)13-22(24)29/h15-24,28-30H,5-14H2,1-4H3,(H,31,32)/t15-,16?,17+,18-,19-,20+,21+,22-,23+,24+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01340 EHMN_ABBREVIATION: C04722
type: Species
is: SBO:0000247
constant: false
boundary condition: false
name: 3alpha,7alpha,12alpha-Trihydroxy-5beta-cholestanoate
is: HMDB03873
has only substance units: false
initial amount: NaN

metaR r2361
product: MODEL1310110063#
name: Organic anion transporter 5 Utilized transport
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
reactant: MODEL1310110063#
kinetic law: MODEL1310110063#
fast: false
is: SBO:0000185
reversible: true
is described by: ECO:0000000

metaR r0853
kinetic law: MODEL1310110063#
reversible: false
name: Facilitated diffusion
reactant: MODEL1310110063#
is described by: ECO:0000000
fast: false
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Purine catabolism EC Number: Confidence Level: 0 AUTHORS: PMID:8132483 NOTES:
product: MODEL1310110063#
type: Reaction

metaR C4CRNe
kinetic law: MODEL1310110063#
product: MODEL1310110063#
reactant: MODEL1310110063#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of butyryl carnitine into the extra cellular space
type: Reaction

metaR GPIMTer U
modifier: MODEL1310110063#
is: SBO:0000176
reversible: false
name: GlcN-acylPI mannosyltransferase, endoplasmic reticulum
notes: GENE_ASSOCIATION: (93183.1) and (54965.1) SUBSYSTEM: Phosphatidylinositol phosphate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:11226175,PMID:15635094 NOTES:NCD
fast: false
type: Reaction
product: MODEL1310110063#
is described by: ECO:0000000
kinetic law: MODEL1310110063#
reactant: MODEL1310110063#

metaR ABUTt2r
kinetic law: MODEL1310110063#
name: 4-aminobutyrate reversible transport in via proton symport
type: Reaction
notes: GENE_ASSOCIATION: (206358.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11390972,PMID:11959859 NOTES:SAB r
is described by: ECO:0000304
reactant: MODEL1310110063#
product: MODEL1310110063#
reversible: true
is: SBO:0000185
fast: false
modifier: MODEL1310110063#

metaR TAURt4 2 r
modifier: MODEL1310110063#
reactant: MODEL1310110063#
reversible: true
product: MODEL1310110063#
fast: false
is described by: ECO:0000269
type: Reaction
is: SBO:0000185
name: taurine transport (sodium symport) (2:1)
kinetic law: MODEL1310110063#
notes: GENE_ASSOCIATION: (6533.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12719981 NOTES:SAB

metaR EX txa2 LPAREN e RPAREN
kinetic law: MODEL1310110063#
reactant: MODEL1310110063#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Thromboxane A2 exchange
type: Reaction

metaR r1538
modifier: MODEL1310110063#
kinetic law: MODEL1310110063#
reactant: MODEL1310110063#
name: Anion Exchanger (AE) TCDB:2.A.31.2.8
is: SBO:0000185
product: MODEL1310110063#
is version of: http://identifiers.org/ec-code/1.17.4.1
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (BE966236.1) or (6240.1) or (6241.1) or (50484.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14722772 NOTES:
fast: false
type: Reaction
reversible: false

metaR GALASE20ly
kinetic law: MODEL1310110063#
fast: false
is: SBO:0000176
reactant: MODEL1310110063#
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) or (5476.1) and (2720.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.23 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD
name: beta-galactosidase, lysosomal
reversible: false
modifier: MODEL1310110063#
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/3.2.1.23
is version of: http://identifiers.org/ec-code/3.2.1.18
product: MODEL1310110063#
type: Reaction
is version of: http://identifiers.org/ec-code/3.4.16.5
is version of: http://identifiers.org/ec-code/3.1.6.4

metaR EX 3ddcrn
kinetic law: MODEL1310110063#
reactant: MODEL1310110063#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for 3-hydroxydodecanoyl carnitine
type: Reaction

metaM q10h2 m
is: HMDB13111
is: SBO:0000247
initial concentration: 1.0
is: http://identifiers.org/pubchem.compound/6504740
notes: FORMULA: C59H92O4 CHARGE: 0 INCHI: InChI=1/C59H92O4/c1-44(2)24-15-25-45(3)26-16-27-46(4)28-17-29-47(5)30-18-31-48(6)32-19-33-49(7)34-20-35-50(8)36-21-37-51(9)38-22-39-52(10)40-23-41-53(11)42-43-55-54(12)56(60)58(62-13)59(63-14)57(55)61/h24,26,28,30,32,34,36,38,40,42,60-61H,15-23,25,27,29,31,33,35,37,39,41,43H2,1-14H3/b45-26+,46-28+,47-30+,48-32+,49-34+,50-36+,51-38+,52-40+,53-42+ HEPATONET_1.0_ABBREVIATION: HC00324
type: Species
name: Ubiquinol-10
boundary condition: false
initial amount: NaN
constant: false
has only substance units: false

metaR FAS140COA
fast: false
reversible: false
is: SBO:0000176
modifier: MODEL1310110063#
product: MODEL1310110063#
is version of: http://identifiers.org/ec-code/2.3.1.85
notes: GENE_ASSOCIATION: (2194.1) SUBSYSTEM: Fatty acid synthesis EC Number: 2.3.1.86 Confidence Level: 4 AUTHORS: PMID:11756679,PMID:15507492,PMID:2669958 NOTES:NCD
reactant: MODEL1310110063#
name: fatty-acyl-CoA synthase (n-C14:0CoA)
kinetic law: MODEL1310110063#
is described by: ECO:0000269
type: Reaction

metaM pail4p hs n
initial concentration: 1.0
boundary condition: false
is: CHEBI:58178
notes: FORMULA: C9H15O12P2FULLRCO2FULLR2CO2 CHARGE: -3 EHMN_ABBREVIATION: C01277
type: Species
has only substance units: false
name: 1-phosphatidyl-1D-myo-inositol 4-phosphate(3-)
constant: false
initial amount: NaN
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110063#_b544e1f2_dc59_4fa8_810b_ec512ca7b1c9
constant: false
is: SBO:0000252
type: Species
boundary condition: true
is encoded by: hsa:5297
initial concentration: NaN
has only substance units: false
name: PI4KA
initial amount: NaN
is: B4DYG5

metaR FORMCOAtx
product: MODEL1310110063#
is described by: ECO:0000000
reactant: MODEL1310110063#
name: formyl coa transport
is: SBO:0000185
type: Reaction
kinetic law: MODEL1310110063#
reversible: true
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: NOTES:unknown mechanism see Verhoeven 11591435 and clayton 11356171 - added for peroxisomal oxidation of fatty acids NJ

metaM acnam c
is: SBO:0000247
is: HMDB00230
initial concentration: 1.0
name: N-acetylneuraminate
boundary condition: false
initial amount: NaN
has only substance units: false
type: Species
notes: FORMULA: C11H18NO9 CHARGE: -1 INCHI: InChI=1S/C11H19NO9/c1-4(14)12-7-5(15)2-11(20,10(18)19)21-9(7)8(17)6(16)3-13/h5-9,13,15-17,20H,2-3H2,1H3,(H,12,14)(H,18,19)/p-1/t5-,6+,7+,8+,9+,11?/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00244 EHMN_ABBREVIATION: C00270
is: CHEBI:35418
constant: false

metaR CERT1gt
reactant: MODEL1310110063#
is version of: http://identifiers.org/ec-code/2.7.11.1
product: MODEL1310110063#
is described by: ECO:0000304
is: SBO:0000185
notes: GENE_ASSOCIATION: (10087.1) SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 2 AUTHORS: PMID:12803919,PMID:14685229,PMID:15596449,PMID:15907394 NOTES:non-vesicular intracellular transport of ceramide
kinetic law: MODEL1310110063#
modifier: MODEL1310110063#
name: ceramide transport protein
reversible: true
fast: false
type: Reaction

metaR r2362
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
type: Reaction
product: MODEL1310110063#
name: Organic anion transporter 5 Utilized transport
reversible: true
kinetic law: MODEL1310110063#
reactant: MODEL1310110063#
is described by: ECO:0000000
is: SBO:0000185

metaM cspg a e
is: CHEBI:17568
boundary condition: false
constant: false
has only substance units: false
is: SBO:0000247
notes: FORMULA: C45H66N2O45S3X CHARGE: -5
is: HMDB00300
is: C00106
initial concentration: 1.0
initial amount: NaN
name: chondroitin sulfate A (GalNAc4S-GlcA) proteoglycan
type: Species

metaR ACNACNGALGBSIDEte
name: acnacngalgbside hs transport
is described by: ECO:0000000
reversible: true
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 1 AUTHORS: PMID:8206147 NOTES:unknown mechanism for transport - intracellular transport occurs, most details are unknown - see for example Varki glycobiology text or numerous reviews (PMID: 8206147) - extracellular transport is also made available since metabolites can get to outer plasma membrane NJ
kinetic law: MODEL1310110063#
is: SBO:0000185
fast: false
product: MODEL1310110063#
reactant: MODEL1310110063#

metaM c8crn e
is: C02838
initial amount: NaN
has only substance units: false
boundary condition: false
initial concentration: 1.0
constant: false
type: Species
is: HMDB00791
name: octanoyl carnitine
notes: FORMULA: C15H29NO4 CHARGE: 0
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110063#_5f48800c_c1f1_4b30_b5e3_3a99471cda90
initial concentration: NaN
is: SBO:0000252
has only substance units: false
is: O75747
constant: false
is encoded by: hsa:5288
initial amount: NaN
name: PIK3C2G
type: Species
boundary condition: true

metaM dhbpt c
notes: FORMULA: C9H13N5O3 CHARGE: 0 INCHI: InChI=1S/C9H13N5O3/c1-3(15)6(16)4-2-11-7-5(12-4)8(17)14-9(10)13-7/h3-4,6,15-16H,2H2,1H3,(H3,10,11,13,14,17) HEPATONET_1.0_ABBREVIATION: HC00242 EHMN_ABBREVIATION: C00268
has only substance units: false
initial amount: NaN
is: CHEBI:20680
initial concentration: 1.0
is: HMDB00038
is: SBO:0000247
constant: false
type: Species
boundary condition: false
name: 6,7-dihydrobiopterin

http://identifiers.org/biomodels.db/MODEL1310110063#_6bc39131_0a0a_4ca1_b93b_a1906b0e7a50
name: SLC2A14
is: SBO:0000252
constant: false
initial amount: NaN
is encoded by: hsa:144195
has only substance units: false
type: Species
boundary condition: true
is: Q8TDB8
initial concentration: NaN

metaR TALA
type: Reaction
is described by: ECO:0000000
fast: false
is version of: http://identifiers.org/ec-code/2.2.1.2
reactant: MODEL1310110063#
is: SBO:0000176
name: transaldolase
kinetic law: MODEL1310110063#
reversible: true
modifier: MODEL1310110063#
notes: GENE_ASSOCIATION: (6888.1) SUBSYSTEM: Pentose phosphate pathway EC Number: 2.2.1.2 Confidence Level: 0 AUTHORS: NOTES:SMP
product: MODEL1310110063#

metaM 3hdcoa m
initial amount: NaN
notes: FORMULA: C31H50N7O18P3S CHARGE: -4
boundary condition: false
is: http://identifiers.org/pubchem.compound/16019966
type: Species
is: SBO:0000247
constant: false
has only substance units: false
initial concentration: 1.0
name: (S)-3-Hydroxydecanoyl-CoA

metaM lpchol hs e
initial amount: NaN
type: Species
is: SBO:0000247
initial concentration: 1.0
boundary condition: false
has only substance units: false
name: lysophosphatidylcholine
constant: false
is: CHEBI:60479
notes: FORMULA: C8H19NO5PFULLRCO2 CHARGE: 0

metaM tdcrn c
constant: false
is: HMDB05066
initial amount: NaN
has only substance units: false
type: Species
notes: FORMULA: C21H41NO4 CHARGE: 0
name: myristoyl carnitine
initial concentration: 1.0
boundary condition: false
is: SBO:0000247

metaM 4fumacac c
boundary condition: false
notes: FORMULA: C8H6O6 CHARGE: -2 INCHI: InChI=1S/C8H8O6/c9-5(1-2-7(11)12)3-6(10)4-8(13)14/h1-2H,3-4H2,(H,11,12)(H,13,14)/p-2/b2-1+ HEPATONET_1.0_ABBREVIATION: HC00648 EHMN_ABBREVIATION: C01061
is: HMDB01268
type: Species
has only substance units: false
initial amount: NaN
constant: false
is: SBO:0000247
name: 4-fumarylacetoacetate(2-)
is: CHEBI:18034
initial concentration: 1.0

metaR r2363
is described by: ECO:0000000
name: Organic anion transporter 5 Utilized transport
product: MODEL1310110063#
type: Reaction
reactant: MODEL1310110063#
kinetic law: MODEL1310110063#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
fast: false
reversible: true

metaM HC00591 m
has only substance units: false
name: 2-oxoglutaramate
initial concentration: 1.0
initial amount: NaN
constant: false
notes: FORMULA: C5H6NO4 CHARGE: -1 INCHI: InChI=1S/C5H7NO4/c6-4(8)2-1-3(7)5(9)10/h1-2H2,(H2,6,8)(H,9,10)/p-1 EHMN_ABBREVIATION: C00940
boundary condition: false
is: CHEBI:16769
type: Species
is: SBO:0000247

metaR COQ5m
name: Ubiquinone biosynthesis methyltransferase COQ5
kinetic law: MODEL1310110063#
reactant: MODEL1310110063#
is: SBO:0000176
is described by: ECO:0000000
reversible: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Ubiquinone synthesis EC Number: Confidence Level: 2 AUTHORS: PMID:10777520,PMID:1965190,PMID:7380842 NOTES:_2.1.1.- IT
product: MODEL1310110063#
type: Reaction
fast: false

http://identifiers.org/biomodels.db/MODEL1310110063#_cdbcff1c_9ae6_40a8_9603_c1da38c25aca
initial concentration: NaN
boundary condition: true
is: Q6IBC4
initial amount: NaN
is encoded by: hsa:4726
constant: false
type: Species
has only substance units: false
is: SBO:0000252
name: NDUFS6

http://identifiers.org/biomodels.db/MODEL1310110063#_66cab2f0_aa87_47d3_af62_1142e3987be5
boundary condition: true
is encoded by: hsa:6647
type: Species
is: SBO:0000252
name: SOD1
has only substance units: false
initial concentration: NaN
initial amount: NaN
constant: false
is: P00441

metaM docosahexcoa m
initial concentration: 1.0
boundary condition: false
type: Species
has only substance units: false
notes: FORMULA: C43H62N7O17P3S CHARGE: -4
constant: false
name: 3,7,10,13,16,19-docosahexenoylcoa
is: http://identifiers.org/pubchem.compound/24892790
initial amount: NaN
is: SBO:0000247

metaM fdp c
is: SBO:0000247
notes: FORMULA: C6H10O12P2 CHARGE: -4 INCHI: " HEPATONET_1.0_ABBREVIATION: HC00300 EHMN_ABBREVIATION: C00354
initial amount: NaN
constant: false
is: HMDB01058
is: http://identifiers.org/pubchem.compound/3647
is: CHEBI:16905
is: C00354
has only substance units: false
type: Species
boundary condition: false
initial concentration: 1.0
name: D-Fructose 1,6-bisphosphate

metaR r0410
is: SBO:0000176
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Pyrimidine catabolism EC Number: 3.6.1.19 Confidence Level: 0 AUTHORS: PMID:15652174,PMID:16752921,PMID:17095758 NOTES:
product: MODEL1310110063#
type: Reaction
reactant: MODEL1310110063#
name: 2-Deoxyguanosine 5-triphosphate pyrophosphohydrolase Purine metabolism EC:3.6.1.19
kinetic law: MODEL1310110063#
is described by: ECO:0000000
fast: false

metaM atp n
constant: false
notes: FORMULA: C10H12N5O13P3 CHARGE: -4 INCHI: InChI=1S/C10H16N5O13P3/c11-8-5-9(13-2-12-8)15(3-14-5)10-7(17)6(16)4(26-10)1-25-30(21,22)28-31(23,24)27-29(18,19)20/h2-4,6-7,10,16-17H,1H2,(H,21,22)(H,23,24)(H2,11,12,13)(H2,18,19,20)/p-3/t4-,6-,7-,10-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00012 EHMN_ABBREVIATION: C00002
boundary condition: false
initial concentration: 1.0
is: SBO:0000247
name: ATP(3-)
has only substance units: false
is: HMDB00538
initial amount: NaN
type: Species
is: CHEBI:57299

metaR r0268
product: MODEL1310110063#
reactant: MODEL1310110063#
reversible: true
name: cytidine monophospho-N-acetylneuraminic acid hydroxylase EC:1.14.18.2
is described by: ECO:0000000
modifier: MODEL1310110063#
kinetic law: MODEL1310110063#
is version of: http://identifiers.org/ec-code/3.1.3.2
is: SBO:0000176
fast: false
notes: GENE_ASSOCIATION: (52.1) or (53.1) or (54.1) or (51205.1) or (55.1) or (AI191472.1) or (248.1) or (249.1) or (250.1) or (251.1) SUBSYSTEM: Unassigned EC Number: 1.14.18.2 Confidence Level: 0 AUTHORS: PMID:10052592,PMID:1964451,PMID:2249689 NOTES:
is version of: http://identifiers.org/ec-code/3.1.3.1
type: Reaction

metaM ocdcea c
name: octadecenoate (n-C18:1)
boundary condition: false
is: C00712
is: SBO:0000247
constant: false
is: HMDB00207
initial amount: NaN
notes: FORMULA: C18H33O2 CHARGE: -1
type: Species
is: CHEBI:0
initial concentration: 1.0
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110063#_f9321763_625e_4ba9_84f4_c0acb3290e7e
constant: false
is: SBO:0000252
initial amount: NaN
initial concentration: NaN
type: Species
is encoded by: hsa:91734
name: IDI2
boundary condition: true
has only substance units: false
is: Q9BXS1

metaR CYTK7n
reactant: MODEL1310110063#
kinetic law: MODEL1310110063#
modifier: MODEL1310110063#
fast: false
name: cytidylate kinase (CMP,UTP),nuclear
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
reversible: true
product: MODEL1310110063#
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/2.7.4.14
is: SBO:0000176
type: Reaction

metaM prostgd2 r
constant: false
type: Species
is: SBO:0000247
initial amount: NaN
has only substance units: false
name: prostaglandin D2(1-)
is: CHEBI:57406
boundary condition: false
notes: FORMULA: C20H31O5 CHARGE: -1 INCHI: InChI=1S/C20H32O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h4,7,12-13,15-18,21-22H,2-3,5-6,8-11,14H2,1H3,(H,24,25)/p-1/b7-4-,13-12+/t15-,16+,17+,18-/m0/s1 EHMN_ABBREVIATION: C00696
initial concentration: 1.0
is: HMDB01403

http://identifiers.org/biomodels.db/MODEL1310110063#_794d5c0f_bc25_4a06_8a1b_ffa1ed8cad84
initial amount: NaN
has only substance units: false
constant: false
is encoded by: hsa:26503
initial concentration: NaN
name: SLC17A5
is: SBO:0000252
is: Q9NRA2
type: Species
boundary condition: true

metaM Ser Gly Ala X Gly l
name: protein-linked serine residue (glycosaminoglycan attachment site)
is: CHEBI:36005
initial concentration: 1.0
boundary condition: false
initial amount: NaN
type: Species
is: SBO:0000247
has only substance units: false
constant: false
notes: FORMULA: XH CHARGE: 0
is: HMDB02183

metaR EX prpp LPAREN e RPAREN
kinetic law: MODEL1310110063#
reactant: MODEL1310110063#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of 5-O-phosphonato-alpha-D-ribofuranosyl diphosphate(5-)
type: Reaction

metaR r2364
fast: false
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
reversible: true
product: MODEL1310110063#
name: Organic anion transporter 5 Utilized transport
reactant: MODEL1310110063#
is described by: ECO:0000000
is: SBO:0000185
kinetic law: MODEL1310110063#

metaM 3hexdcrn c
is: SBO:0000247
has only substance units: false
is: HMDB13336
constant: false
initial amount: NaN
type: Species
notes: FORMULA: C23H45NO5 CHARGE: 0
initial concentration: 1.0
name: 3-hydroxyhexadecanoylcarnitine
boundary condition: false

metaR G14T19g
reactant: MODEL1310110063#
is version of: http://identifiers.org/ec-code/2.4.1.38
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.4.1.90
fast: false
is version of: http://identifiers.org/ec-code/2.4.1.22
product: MODEL1310110063#
type: Reaction
kinetic law: MODEL1310110063#
notes: GENE_ASSOCIATION: (9334.1) or (8704.1) or (8703.1) or (8704.2) or (2683.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.38 Confidence Level: 4 AUTHORS: PMID:10747980,PMID:12512857,PMID:1903938,PMID:3094506,PMID:3144273,PMID:9405390,PMID:9435216 NOTES:Keratan sulfate II biosynthesis NCD
is described by: ECO:0000000
reversible: false
modifier: MODEL1310110063#
name: beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase, Golgi

http://identifiers.org/biomodels.db/MODEL1310110063#_52cfed13_f31e_40e5_8403_533232259ba1
name: PIP4K2A
is: P48426
has only substance units: false
boundary condition: true
is: SBO:0000252
type: Species
is encoded by: hsa:5305
initial amount: NaN
constant: false
initial concentration: NaN

metaM ksi pre5 g
notes: FORMULA: C101H164N7O75SX CHARGE: -2
name: keratan sulfate I biosynthesis, precursor 5
constant: false
has only substance units: false
is: CHEBI:28067
boundary condition: false
initial amount: NaN
initial concentration: 1.0
type: Species
is: SBO:0000247

metaR DDPGAm
is: SBO:0000176
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Arginine and Proline Metabolism EC Number: 4.1.2.14 Confidence Level: 2 AUTHORS: PMID:12660328,PMID:14193832,PMID:15849464,PMID:9783918 NOTES:IT rxn is done by 4.1.2.14 and 4.1.3.16 mitochondrial isozyme - NCD
reactant: MODEL1310110063#
name: 2-dehydro-3-deoxy-phosphogluconate aldolase, mitochondrial
kinetic law: MODEL1310110063#
is described by: ECO:0000000
product: MODEL1310110063#
reversible: true
type: Reaction

metaM thcholstoic m
is: SBO:0000247
is: HMDB03873
notes: FORMULA: C27H45O5 CHARGE: -1 INCHI: InChI=1S/C27H46O5/c1-15(6-5-7-16(2)25(31)32)19-8-9-20-24-21(14-23(30)27(19,20)4)26(3)11-10-18(28)12-17(26)13-22(24)29/h15-24,28-30H,5-14H2,1-4H3,(H,31,32)/t15-,16?,17+,18-,19-,20+,21+,22-,23+,24+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01340 EHMN_ABBREVIATION: C04722
type: Species
is: CHEBI:18402
initial amount: NaN
constant: false
has only substance units: false
name: 3alpha,7alpha,12alpha-Trihydroxy-5beta-cholestanoate
boundary condition: false
initial concentration: 1.0

metaR ACNACNGALGBSIDEtg
fast: false
is described by: ECO:0000000
name: acnacngalgbside hs intracellular transport
type: Reaction
product: MODEL1310110063#
is: SBO:0000185
kinetic law: MODEL1310110063#
reactant: MODEL1310110063#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 1 AUTHORS: PMID:8206147 NOTES:unknown mechanism for transport - intracellular transport occurs, most details are unknown - see for example Varki glycobiology text or numerous reviews (PMID: 8206147) NJ
reversible: true

metaR FAOXC18C18OHm
kinetic law: MODEL1310110063#
product: MODEL1310110063#
reactant: MODEL1310110063#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C18-->C18OH)m
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110063#_fa6cc9b9_e4f4_4ccd_8052_20a1716a7c57
initial amount: NaN
constant: false
is encoded by: hsa:54344
is: Q86TM7
initial concentration: NaN
boundary condition: true
type: Species
is: SBO:0000252
has only substance units: false
name: DPM3

metaR CO2t
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 1 AUTHORS: NOTES:tv renamed from CO2TPr to CO2t NCD
fast: false
is described by: ECO:0000000
is: SBO:0000185
type: Reaction
name: CO2 transporter via diffusion
reactant: MODEL1310110063#
reversible: true
product: MODEL1310110063#
kinetic law: MODEL1310110063#

metaM atp m
initial concentration: 1.0
name: ATP(4-)
constant: false
is: C00002
is: SBO:0000247
is: CHEBI:57299
has only substance units: false
is: HMDB00538
initial amount: NaN
boundary condition: false
type: Species

metaM methf m
initial concentration: 1.0
name: (6R)-5,10-methenyltetrahydrofolate
notes: FORMULA: C20H20N7O6 CHARGE: -1 INCHI: InChI=1S/C20H21N7O6/c21-20-24-16-15(18(31)25-20)27-9-26(8-12(27)7-22-16)11-3-1-10(2-4-11)17(30)23-13(19(32)33)5-6-14(28)29/h1-4,9,12-13H,5-8H2,(H6-,21,22,23,24,25,28,29,30,31,32,33)/p-1/t12-,13+/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00360 EHMN_ABBREVIATION: C00445
is: SBO:0000247
has only substance units: false
initial amount: NaN
is: HMDB01354
constant: false
boundary condition: false
is: CHEBI:57455
type: Species

metaR r2365
kinetic law: MODEL1310110063#
type: Reaction
product: MODEL1310110063#
reactant: MODEL1310110063#
fast: false
reversible: true
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
is described by: ECO:0000000
name: Organic anion transporter 5 Utilized transport

metaM ocde9ecoa x
boundary condition: false
has only substance units: false
type: Species
initial concentration: 1.0
initial amount: NaN
is: SBO:0000247
is: http://identifiers.org/pubchem.compound/5280355
notes: FORMULA: C39H64N7O17P3S CHARGE: -4
name: 9-octadecenoylcoa
constant: false

metaR r0267
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/3.5.1.9
name: CMP-N-acetylneuraminate,ferrocytochrome-b5:oxygen oxidoreductase (N-acetyl-hydroxylating) Aminosugars metabolism EC:1.14.18.2
reversible: true
notes: GENE_ASSOCIATION: (125061.1) SUBSYSTEM: Unassigned EC Number: 1.14.18.2 Confidence Level: 0 AUTHORS: PMID:11211935,PMID:2249689,PMID:8112313 NOTES:
reactant: MODEL1310110063#
is: SBO:0000176
fast: false
modifier: MODEL1310110063#
kinetic law: MODEL1310110063#
product: MODEL1310110063#
type: Reaction

metaR OCTDECE1CRNe
kinetic law: MODEL1310110063#
product: MODEL1310110063#
reactant: MODEL1310110063#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of 3-hydroxy-octadecenoyl carnitine into extra cellular space
type: Reaction

metaM so4 l
is: HMDB01448
type: Species
constant: false
is: SBO:0000247
boundary condition: false
is: CHEBI:16189
has only substance units: false
initial amount: NaN
notes: FORMULA: O4S CHARGE: -2 INCHI: InChI=1S/H2O4S/c1-5(2,3)4/h(H2,1,2,3,4)/p-2 HEPATONET_1.0_ABBREVIATION: HC00062 EHMN_ABBREVIATION: C00059
initial concentration: 1.0
name: sulfate

metaM lpchol hs c
type: Species
initial amount: NaN
initial concentration: 1.0
has only substance units: false
is: SBO:0000247
boundary condition: false
name: lysophosphatidylcholine
notes: FORMULA: C8H19NO5PFULLRCO2 CHARGE: 0
is: CHEBI:60479
constant: false

http://identifiers.org/biomodels.db/MODEL1310110063#_b090517f_9291_49b8_9895_ef52def5f2a9
constant: false
is: Q9NR34
name: MAN1C1
has only substance units: false
boundary condition: true
is encoded by: hsa:57134
initial concentration: NaN
type: Species
is: SBO:0000252
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110063#_26695158_8076_4c94_ac5b_a4f081d8b43f
has only substance units: false
type: Species
boundary condition: true
initial concentration: NaN
is: SBO:0000252
name: PDE7A
is: Q13946
initial amount: NaN
is encoded by: hsa:5150
constant: false

metaR EX dag hs LPAREN e RPAREN
kinetic law: MODEL1310110063#
reactant: MODEL1310110063#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for diglyceride
type: Reaction

metaR NACHEX20ly
kinetic law: MODEL1310110063#
is: SBO:0000176
type: Reaction
modifier: MODEL1310110063#
reversible: false
reactant: MODEL1310110063#
product: MODEL1310110063#
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/3.2.1.52
name: beta-N-acetylhexosaminidase, lysosomal
fast: false
notes: GENE_ASSOCIATION: (3073.1 and 3074.1) or (3074.1) or (3073.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.52 Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12706724,PMID:8993162 NOTES:NCD

metaR S6TASE1ly
notes: GENE_ASSOCIATION: (2799.1) SUBSYSTEM: Heparan sulfate degradation EC Number: 3.1.6.14 Confidence Level: 4 AUTHORS: PMID:3196333,PMID:3689314,PMID:3689315 NOTES:NCD
is described by: ECO:0000000
kinetic law: MODEL1310110063#
is version of: http://identifiers.org/ec-code/3.1.6.14
reactant: MODEL1310110063#
reversible: true
type: Reaction
fast: false
product: MODEL1310110063#
name: N-acetylglucosamine-6-sulfatase, lysosomal
modifier: MODEL1310110063#
is: SBO:0000176

metaR LNLNCAt
name: fatty acid transport via diffusion
product: MODEL1310110063#
type: Reaction
is: SBO:0000185
reactant: MODEL1310110063#
kinetic law: MODEL1310110063#
reversible: true
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11788354,PMID:12864740 NOTES:NJ
fast: false

metaR G13MT U
modifier: MODEL1310110063#
is version of: http://identifiers.org/ec-code/2.4.1.132
fast: false
is: SBO:0000176
kinetic law: MODEL1310110063#
reactant: MODEL1310110063#
is described by: ECO:0000000
reversible: false
name: Glycolipid 1,3-alpha-D-mannosyltransferase (uterus)
type: Reaction
product: MODEL1310110063#
notes: GENE_ASSOCIATION: (85365.1) or (85365.2) SUBSYSTEM: N-glycan synthesis EC Number: 2.4.1.132 Confidence Level: 0 AUTHORS: NOTES:NCD

http://identifiers.org/biomodels.db/MODEL1310110063#_f28bca00_cd19_47ce_9fd9_f3701ec702de
boundary condition: true
initial amount: NaN
is: Q9BYZ2
name: LDHAL6B
constant: false
type: Species
is encoded by: hsa:92483
initial concentration: NaN
is: SBO:0000252
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110063#_575ed67a_348a_4984_b0b6_817bbe8afda8
is: B3KUV7
is: SBO:0000252
name: PIGA
initial amount: NaN
boundary condition: true
constant: false
has only substance units: false
initial concentration: NaN
type: Species
is encoded by: hsa:5277

metaR XYLUR
kinetic law: MODEL1310110063#
type: Reaction
modifier: MODEL1310110063#
notes: GENE_ASSOCIATION: (51181.1) SUBSYSTEM: Pentose phosphate pathway EC Number: 1.1.1.10 Confidence Level: 4 AUTHORS: PMID:11882650,PMID:6821187 NOTES:
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/1.1.1.10
reversible: true
fast: false
is: SBO:0000176
reactant: MODEL1310110063#
product: MODEL1310110063#
name: xylulose reductase

metaR r0594
type: Reaction
kinetic law: MODEL1310110063#
modifier: MODEL1310110063#
is version of: http://identifiers.org/ec-code/1.2.1.3
reactant: MODEL1310110063#
fast: false
product: MODEL1310110063#
is described by: ECO:0000000
is: SBO:0000176
notes: GENE_ASSOCIATION: (AA081045.1) or (AI620219.1) or (219.1) or (217.1) or (224.1) or (501.1) or (223.1) or (AU149534.1) or (T83654.1) SUBSYSTEM: Lysine metabolism EC Number: 1.2.1.31 Confidence Level: 0 AUTHORS: PMID:2160277 NOTES:
reversible: true
name: L-2-Aminoadipate-6-semialdehyde:NAD+ 6-oxidoreductase Lysine degradation EC:1.2.1.31

http://identifiers.org/biomodels.db/MODEL1310110063#_a71c86ff_c815_4f44_b67a_0a7aadb1a9fb
initial concentration: NaN
is encoded by: hsa:BF195998
constant: false
name: _BF195998_1_x
boundary condition: true
initial amount: NaN
type: Species
is: SBO:0000252
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110063#_d1fdd898_3c6e_4cb9_a399_9d2fa06628ce
initial amount: NaN
is: SBO:0000252
type: Species
boundary condition: true
initial concentration: NaN
name: _MBOAT5_1_c
has only substance units: false
is encoded by: hsa:MBOAT5
constant: false

http://identifiers.org/biomodels.db/MODEL1310110063#_099a2bca_0e23_4fc2_a1bb_051c3edf1445
initial amount: NaN
constant: false
is: Q9Y2Q0
initial concentration: NaN
type: Species
is: SBO:0000252
has only substance units: false
name: ATP8A1
boundary condition: true
is encoded by: hsa:10396

http://identifiers.org/biomodels.db/MODEL1310110063#_81f6183f_80c2_4857_a0af_b2ff73096ee9
is: SBO:0000297
initial amount: NaN
has only substance units: false
boundary condition: true
name: ATP5H:ATP5L:NSF:ATP5F1:ATP5G3:ATP5I:ATP5J:ATP5J2
type: Species
is encoded by: hsa:515
constant: false
initial concentration: NaN

metaR r2369
reactant: MODEL1310110063#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
type: Reaction
product: MODEL1310110063#
name: Organic anion transporter 5 Utilized transport
is: SBO:0000185
fast: false
reversible: true
kinetic law: MODEL1310110063#
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110063#_34fdc025_2759_44f2_b069_b9c2e8dbb8dd
is: Q53HM1
initial amount: NaN
type: Species
has only substance units: false
initial concentration: NaN
boundary condition: true
name: UCKL1
constant: false
is: SBO:0000252
is encoded by: hsa:54963

http://identifiers.org/biomodels.db/MODEL1310110063#_8c3c090e_341f_44ae_a6cc_ba8cfe71a3a4
boundary condition: true
is encoded by: hsa:1719
is: P00374
initial concentration: NaN
initial amount: NaN
constant: false
is: SBO:0000252
has only substance units: false
type: Species
name: DHFR

metaR AG13T4g
reactant: MODEL1310110063#
is version of: http://identifiers.org/ec-code/2.4.1.149
notes: GENE_ASSOCIATION: (11041.1) or (10678.1) or (93010.1) or (10331.1) or (374907.1) or (146712.1) or (374907.2) or (10678.2) or (79369.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.149 Confidence Level: 4 AUTHORS: PMID:10747980,PMID:11042166,PMID:12061784,PMID:12512857,PMID:15560372,PMID:15620693,PMID:9405606 NOTES:NCD
fast: false
kinetic law: MODEL1310110063#
product: MODEL1310110063#
name: N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase, Golgi apparatus
is: SBO:0000176
reversible: false
is described by: ECO:0000000
modifier: MODEL1310110063#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110063#_20a0917a_352a_40ae_b6b2_c3f644b52c58
initial concentration: NaN
initial amount: NaN
is: P78356
boundary condition: true
is: SBO:0000252
constant: false
type: Species
name: PIP4K2B
has only substance units: false
is encoded by: hsa:8396

metaM pe hs r
has only substance units: false
is: SBO:0000247
initial concentration: 1.0
constant: false
name: phosphatidylethanolamine
notes: FORMULA: C5H12NO4PFULLRCO2FULLR2CO2 CHARGE: 0
boundary condition: false
is: CHEBI:16038
type: Species
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110063#_5d6db763_9a95_4329_a899_f2311880cd7c
initial concentration: NaN
is encoded by: hsa:4539
has only substance units: false
initial amount: NaN
is: SBO:0000252
name: ND4L
boundary condition: true
type: Species
constant: false
is: Q7GXZ4

metaR HPDCACRNCPT1
kinetic law: MODEL1310110063#
product: MODEL1310110063#
is described by: ECO:0000000
reversible: false
modifier: MODEL1310110063#
fast: false
name: carnitine fatty-acyl transferase
is version of: http://identifiers.org/ec-code/2.3.1.21
reactant: MODEL1310110063#
notes: GENE_ASSOCIATION: (1375.2) or (1375.3) or (1374.1) or (126129.1) or (1375.1) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.21 Confidence Level: 4 AUTHORS: PMID:1988962 NOTES:NJ
is: SBO:0000176
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110063#_a84713e9_92a0_413f_93fa_afcaec2785d8
has only substance units: false
constant: false
initial concentration: NaN
boundary condition: true
is: SBO:0000252
type: Species
name: SLC20A1
initial amount: NaN
is: Q8WUM9
is encoded by: hsa:6574

metaR r2368
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
reactant: MODEL1310110063#
fast: false
is described by: ECO:0000000
is: SBO:0000185
reversible: true
product: MODEL1310110063#
kinetic law: MODEL1310110063#
type: Reaction
name: Organic anion transporter 5 Utilized transport

metaM gal c
is: CHEBI:0
initial amount: NaN
constant: false
is: C00124
type: Species
notes: FORMULA: C6H12O6 CHARGE: 0
is: HMDB00143
boundary condition: false
initial concentration: 1.0
has only substance units: false
is: SBO:0000247
name: D-Galactose

metaM atp r
is: HMDB00538
is: CHEBI:57299
is: SBO:0000247
type: Species
name: ATP(4-)
has only substance units: false
boundary condition: false
initial concentration: 1.0
is: C00002
initial amount: NaN
constant: false

metaR r1544
kinetic law: MODEL1310110063#
is described by: ECO:0000000
product: MODEL1310110063#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
type: Reaction
fast: false
is: SBO:0000185
reactant: MODEL1310110063#
reversible: true
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1

metaM CE0233 c
notes: FORMULA: C27H48O3 CHARGE: 0 INCHI: InChI=1/C27H48O3/c1-17(7-6-12-25(2,3)30)20-8-9-21-24-22(11-14-27(20,21)5)26(4)13-10-19(28)15-18(26)16-23(24)29/h17-24,28-30H,6-16H2,1-5H3/t17-,18-,19+,20-,21-,22-,23+,24-,26?,27-/m1/s1 EHMN_ABBREVIATION: CE0233
has only substance units: false
type: Species
initial amount: NaN
constant: false
boundary condition: false
is: CHEBI:17899
initial concentration: 1.0
is: SBO:0000247
name: 5beta-cholestane-3alpha,7alpha,27-triol
is: HMDB01993

http://identifiers.org/biomodels.db/MODEL1310110063#_6ee659a4_069c_4607_a502_f69f56c28212
is: SBO:0000252
initial amount: NaN
boundary condition: true
constant: false
is: Q13733
type: Species
has only substance units: false
initial concentration: NaN
is encoded by: hsa:480
name: ATP1A4

metaR DM dem2emgacpail prot hs r
kinetic law: MODEL1310110063#
reactant: MODEL1310110063#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 0 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: false
name: DM dem2emgacpail prot hs(r)
type: Reaction

metaR DOLPGT2 Uer
reactant: MODEL1310110063#
product: MODEL1310110063#
type: Reaction
modifier: MODEL1310110063#
notes: GENE_ASSOCIATION: (79053.1) or (79053.3) or (79053.2) SUBSYSTEM: N-glycan synthesis EC Number: Confidence Level: 0 AUTHORS: NOTES:EC 2.4.1.- NCD
is described by: ECO:0000000
kinetic law: MODEL1310110063#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.4.1.265
fast: false
name: dolichyl-phosphate-glucose-glycolipid alpha-glucosyltransferase (uterus)
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110063#_76296dce_0202_473d_9f5c_1f174982995f
is encoded by: hsa:60482
type: Species
is: SBO:0000252
boundary condition: true
is: Q9GZV3
constant: false
initial concentration: NaN
has only substance units: false
initial amount: NaN
name: SLC5A7

metaR r1547
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
type: Reaction
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
product: MODEL1310110063#
kinetic law: MODEL1310110063#
reversible: true
is described by: ECO:0000000
is: SBO:0000185
reactant: MODEL1310110063#
fast: false

http://identifiers.org/biomodels.db/MODEL1310110063#_5dc59abd_9d44_4697_b4ac_c5a65132c449
is encoded by: hsa:9551
is encoded by: hsa:522
has part: Q6IBB3
is encoded by: hsa:515
initial amount: NaN
type: Species
has part: O75964
has part: P05496
has part: P56385
is encoded by: hsa:10632
is encoded by: hsa:516
is encoded by: hsa:521
has only substance units: false
boundary condition: true
has part: A0PJH2
has part: P46459
constant: false
is encoded by: hsa:4905
is encoded by: hsa:10476
is: SBO:0000297
name: ATP5H:ATP5L:NSF:ATP5A1:ATP5B:ATP5C1:ATP5D:ATP5E:ATP5F1:ATP5G1:ATP5I:ATP5J:ATP5J2
has part: Q08ET0
initial concentration: NaN

metaR r2367
fast: false
reversible: true
reactant: MODEL1310110063#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
is: SBO:0000185
kinetic law: MODEL1310110063#
name: Organic anion transporter 5 Utilized transport
product: MODEL1310110063#
is described by: ECO:0000000

metaM ksi pre24 g
boundary condition: false
type: Species
is: SBO:0000247
initial amount: NaN
notes: FORMULA: C191H306N13O158S7X CHARGE: -8
is: CHEBI:58053
name: keratan sulfate I biosynthesis, precursor 24
is: C00130
initial concentration: 1.0
is: HMDB00175
constant: false
has only substance units: false

metaR C14STRr
is: SBO:0000176
modifier: MODEL1310110063#
name: C-14 sterol reductase
reversible: false
type: Reaction
kinetic law: MODEL1310110063#
reactant: MODEL1310110063#
is version of: http://identifiers.org/ec-code/1.3.1.70
notes: GENE_ASSOCIATION: (7108.1) SUBSYSTEM: Cholesterol metabolism EC Number: 1.3.1.70 Confidence Level: 4 AUTHORS: PMID:16784888 NOTES:NCD ER version NJ
product: MODEL1310110063#
is described by: ECO:0000134
fast: false

http://identifiers.org/biomodels.db/MODEL1310110063#_47edf727_68d8_46ba_b6c4_8bf257e8e120
type: Species
is encoded by: hsa:4645
name: MYO5B
has only substance units: false
initial amount: NaN
is: Q9H6Y6
is: SBO:0000252
boundary condition: true
constant: false
initial concentration: NaN

metaM udpglcur r
is: SBO:0000247
is: CHEBI:58052
has only substance units: false
initial concentration: 1.0
is: C00167
name: UDP-D-glucuronate
boundary condition: false
type: Species
initial amount: NaN
constant: false
is: HMDB00935
notes: FORMULA: C15H19N2O18P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00162 EHMN_ABBREVIATION: C00167

metaM gal e
boundary condition: false
initial concentration: 1.0
is: CHEBI:0
notes: FORMULA: C6H12O6 CHARGE: 0
is: SBO:0000247
initial amount: NaN
has only substance units: false
constant: false
is: HMDB00143
name: D-Galactose
type: Species
is: C00124

metaR FMNALKPle
fast: false
is described by: ECO:0000134
name: FMNALKPle
is: SBO:0000176
reactant: MODEL1310110063#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
product: MODEL1310110063#
type: Reaction
reversible: false
kinetic law: MODEL1310110063#

http://identifiers.org/biomodels.db/MODEL1310110063#_11e78472_e4dd_4471_85e5_ec69eca98e40
is encoded by: hsa:79143
name: MBOAT7
initial amount: NaN
is: SBO:0000252
is: Q96N66
initial concentration: NaN
boundary condition: true
constant: false
has only substance units: false
type: Species

metaM gbside hs g
is: CHEBI:18259
notes: FORMULA: C44H79N2O22FULLRCO CHARGE: 0
name: globoside
boundary condition: false
initial concentration: 1.0
initial amount: NaN
constant: false
has only substance units: false
is: SBO:0000247
type: Species

metaR r0400
is described by: ECO:0000000
kinetic law: MODEL1310110063#
is: SBO:0000176
name: N-acetylneuraminate,ferrocytochrome-b5:oxygen oxidoreductase (N-acetyl-hydroxylating) Aminosugars metabolism EC:1.14.18.2
notes: GENE_ASSOCIATION: (594.1) or (641649.1) SUBSYSTEM: Unassigned EC Number: 1.14.18.2 Confidence Level: 0 AUTHORS: PMID:11522391,PMID:12192086 NOTES:
type: Reaction
fast: false
modifier: MODEL1310110063#
reactant: MODEL1310110063#
is version of: http://identifiers.org/ec-code/1.2.4.4
reversible: true
product: MODEL1310110063#

metaR SMS
is described by: ECO:0000269
fast: false
reactant: MODEL1310110063#
reversible: false
product: MODEL1310110063#
modifier: MODEL1310110063#
notes: GENE_ASSOCIATION: (259230.1) SUBSYSTEM: Sphingolipid metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:14685263 NOTES:NJ
is version of: http://identifiers.org/ec-code/2.7.8.27
type: Reaction
kinetic law: MODEL1310110063#
name: Sphingomyelin synthase (homo sapiens)
is: SBO:0000176

metaR r1546
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
product: MODEL1310110063#
kinetic law: MODEL1310110063#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
type: Reaction
is: SBO:0000185
reactant: MODEL1310110063#
fast: false
reversible: true
is described by: ECO:0000000

metaM hs deg6 l
constant: false
boundary condition: false
initial concentration: 1.0
type: Species
notes: FORMULA: C67H98N4O83S9 CHARGE: -10
is: SBO:0000247
initial amount: NaN
is: CHEBI:17180
has only substance units: false
is: HMDB01352
name: heparan sulfate, degradation product 6

metaR r2366
type: Reaction
fast: false
reactant: MODEL1310110063#
kinetic law: MODEL1310110063#
reversible: true
name: Organic anion transporter 5 Utilized transport
is described by: ECO:0000000
product: MODEL1310110063#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:

metaM dectricoa m
boundary condition: false
notes: FORMULA: C31H44N7O17P3S CHARGE: -4
initial concentration: 1.0
is: SBO:0000247
initial amount: NaN
name: 2,4,7-decatrienoylcoa
type: Species
has only substance units: false
constant: false
is: http://identifiers.org/pubchem.compound/16019966

metaR XYLTt
fast: false
name: Xylitol transport via passive diffusion
kinetic law: MODEL1310110063#
is described by: ECO:0000000
product: MODEL1310110063#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 1 AUTHORS: PMID:6821187 NOTES:NCD
type: Reaction
reactant: MODEL1310110063#
reversible: true
is: SBO:0000185

metaR r0590
name: ATP:pantetheine-4-phosphate adenylyltransferase Pantothenate and CoA biosynthesis EC:2.7.7.3
notes: GENE_ASSOCIATION: (220.1) or (218.1) or (221.1) or (222.1) or (U37519.1) SUBSYSTEM: CoA synthesis EC Number: 2.7.7.3 Confidence Level: 0 AUTHORS: PMID:11923312,PMID:11994049,PMID:13163064,PMID:15893380 NOTES:
type: Reaction
reversible: false
is version of: http://identifiers.org/ec-code/1.2.1.5
reactant: MODEL1310110063#
product: MODEL1310110063#
is described by: ECO:0000000
is: SBO:0000176
kinetic law: MODEL1310110063#
modifier: MODEL1310110063#
fast: false

metaM 5mthf c
notes: FORMULA: C20H24N7O6 CHARGE: -1
initial concentration: 1.0
constant: false
is: SBO:0000247
is: C00440
boundary condition: false
initial amount: NaN
name: 5-Methyltetrahydrofolate
is: CHEBI:3729
has only substance units: false
type: Species
is: HMDB01396

metaM 2hb e
is: CHEBI:1148
constant: false
initial concentration: 1.0
initial amount: NaN
is: HMDB00008
notes: FORMULA: C4H7O3 CHARGE: -1 INCHI: InChI=1S/C4H8O3/c1-2-3(5)4(6)7/h3,5H,2H2,1H3,(H,6,7) HEPATONET_1.0_ABBREVIATION: HC01669 EHMN_ABBREVIATION: C05984
type: Species
is: SBO:0000247
boundary condition: false
name: 2-Hydroxybutyrate
has only substance units: false

metaR NADtpu
is: SBO:0000185
reactant: MODEL1310110063#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 0 AUTHORS: NOTES:diffusion - but unidirectional uptake into peroxisome (to avoid loops w/ NAD/NADP) NJ
fast: false
product: MODEL1310110063#
kinetic law: MODEL1310110063#
is described by: ECO:0000000
name: NAD transporter, peroxisome
type: Reaction
reversible: false

metaR RDH3
is: SBO:0000176
name: retinol dehydrogenase (11-cis,NADH)
product: MODEL1310110063#
kinetic law: MODEL1310110063#
notes: GENE_ASSOCIATION: (5959.1) SUBSYSTEM: Vitamin A metabolism EC Number: 1.1.1.105 Confidence Level: 4 AUTHORS: PMID:12226107,PMID:1503811,PMID:7836368 NOTES:IT
fast: false
type: Reaction
is version of: http://identifiers.org/ec-code/1.1.1.315
modifier: MODEL1310110063#
reactant: MODEL1310110063#
reversible: true
is described by: ECO:0000269

http://identifiers.org/biomodels.db/MODEL1310110063#_5b0696c6_93c6_41e1_9400_ff6fbe3a4d6e
initial concentration: NaN
is: SBO:0000252
has only substance units: false
type: Species
is encoded by: hsa:51181
initial amount: NaN
name: DCXR
is: Q7Z4W1
constant: false
boundary condition: true

metaM dcyt c
boundary condition: false
has only substance units: false
constant: false
initial concentration: 1.0
type: Species
is: SBO:0000247
is: CHEBI:15698
name: Deoxycytidine
is: HMDB00014
is: C00881
notes: FORMULA: C9H13N3O4 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00574 EHMN_ABBREVIATION: C00881
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110063#_7a7cca9a_38fe_478c_a146_9aa647f1f964
boundary condition: true
has only substance units: false
is: O00746
name: NME4
constant: false
type: Species
initial amount: NaN
is encoded by: hsa:4833
is: SBO:0000252
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110063#_94e112dd_6822_4ce2_9f7c_7cf279a5720c
boundary condition: true
is: P80404
is: SBO:0000252
has only substance units: false
is encoded by: hsa:18
constant: false
name: ABAT
initial amount: NaN
type: Species
initial concentration: NaN

metaR EX for LPAREN e RPAREN
kinetic law: MODEL1310110063#
reactant: MODEL1310110063#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Formate exchange
type: Reaction

metaM tag hs e
name: triglyceride
is: CHEBI:17855
constant: false
is: SBO:0000247
notes: FORMULA: C3H5FULLRCO2FULLR2CO2FULLR3CO2 CHARGE: 0
initial concentration: 1.0
boundary condition: false
initial amount: NaN
has only substance units: false
type: Species

metaR SERDGLNexR
reversible: true
reactant: MODEL1310110063#
fast: false
name: D-Serine/Glutamine reversible exchange
product: MODEL1310110063#
kinetic law: MODEL1310110063#
is described by: ECO:0000304
type: Reaction
notes: GENE_ASSOCIATION: (56301.1) and (6520.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10734121,PMID:10863037,PMID:14770310 NOTES:
modifier: MODEL1310110063#
is: SBO:0000185

metaR RE1530C
type: Reaction
name: RE1530
product: MODEL1310110063#
notes: GENE_ASSOCIATION: SUBSYSTEM: Pyrimidine synthesis EC Number: 2.7.1.21 Confidence Level: 0 AUTHORS: PMID:11812127 NOTES:
is: SBO:0000176
is described by: ECO:0000000
fast: false
reversible: true
reactant: MODEL1310110063#
kinetic law: MODEL1310110063#

metaR r0591
kinetic law: MODEL1310110063#
type: Reaction
reversible: true
is version of: http://identifiers.org/ec-code/1.2.1.5
fast: false
is described by: ECO:0000000
is: SBO:0000176
notes: GENE_ASSOCIATION: (220.1) or (218.1) or (221.1) or (222.1) or (U37519.1) SUBSYSTEM: CoA synthesis EC Number: 3.6.1.9 Confidence Level: 0 AUTHORS: PMID:11579996,PMID:11946484 NOTES:
modifier: MODEL1310110063#
name: Dephospho-CoA nucleotidohydrolase Pantothenate and CoA biosynthesis EC:3.6.1.9
reactant: MODEL1310110063#
product: MODEL1310110063#

http://identifiers.org/biomodels.db/MODEL1310110063#_0438b5cd_0226_4901_b0d0_e85c453c0c1b
initial concentration: NaN
is encoded by: hsa:AU149534
constant: false
initial amount: NaN
is: SBO:0000252
boundary condition: true
name: _AU149534_1_c
type: Species
has only substance units: false

metaR TYRt
notes: GENE_ASSOCIATION: (117247.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:11827462 NOTES:
reversible: true
name: L-tyrosine transport
kinetic law: MODEL1310110063#
product: MODEL1310110063#
is described by: ECO:0000269
fast: false
modifier: MODEL1310110063#
is: SBO:0000185
type: Reaction
reactant: MODEL1310110063#

metaR OAADC
kinetic law: MODEL1310110063#
product: MODEL1310110063#
reactant: MODEL1310110063#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: oxaloacetate decarboxylase
type: Reaction

metaM HC01399 m
is: SBO:0000247
initial amount: NaN
constant: false
has only substance units: false
type: Species
notes: FORMULA: C35H58N7O18P3S CHARGE: -4 INCHI: InChI=1S/C35H62N7O18P3S/c1-4-5-6-7-8-9-10-11-12-13-23(43)18-26(45)64-17-16-37-25(44)14-15-38-33(48)30(47)35(2,3)20-57-63(54,55)60-62(52,53)56-19-24-29(59-61(49,50)51)28(46)34(58-24)42-22-41-27-31(36)39-21-40-32(27)42/h21-24,28-30,34,43,46-47H,4-20H2,1-3H3,(H,37,44)(H,38,48)(H,52,53)(H,54,55)(H2,36,39,40)(H2,49,50,51)/t23-,24+,28+,29+,30-,34+/m0/s1 EHMN_ABBREVIATION: C05260
is: CHEBI:27466
initial concentration: 1.0
name: (S)-3-Hydroxytetradecanoyl-CoA
boundary condition: false

metaM Rtotal3coa c
constant: false
initial amount: NaN
type: Species
is: CHEBI:16189
has only substance units: false
initial concentration: 1.0
name: R total 3 Coenzyme A
is: SBO:0000247
boundary condition: false
is: HMDB01448
notes: FORMULA: CO2FULLR3C21H31N7O15P3S CHARGE: -4

metaR r1540
is described by: ECO:0000000
product: MODEL1310110063#
fast: false
notes: GENE_ASSOCIATION: (BE966236.1) or (6240.1) or (6241.1) or (50484.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12719981 NOTES:
modifier: MODEL1310110063#
is version of: http://identifiers.org/ec-code/1.17.4.1
reversible: false
type: Reaction
name: Neurotransmitter:Sodium Symporter (NSS) TCDB:2.A.22.3.3
reactant: MODEL1310110063#
kinetic law: MODEL1310110063#
is: SBO:0000185

metaR RDH4
product: MODEL1310110063#
kinetic law: MODEL1310110063#
is: SBO:0000176
reversible: true
type: Reaction
reactant: MODEL1310110063#
is described by: ECO:0000269
name: retinol dehydrogenase (13-cis,NADH)
is version of: http://identifiers.org/ec-code/1.1.1.315
notes: GENE_ASSOCIATION: (5959.1) SUBSYSTEM: Vitamin A metabolism EC Number: 1.1.1.105 Confidence Level: 4 AUTHORS: PMID:9115228 NOTES:IT
fast: false
modifier: MODEL1310110063#

metaM ha pre1 l
initial concentration: 1.0
is: SBO:0000247
constant: false
name: hyaluronan biosynthesis, precursor 1
is: CHEBI:16126
boundary condition: false
notes: FORMULA: C14H20NO11 CHARGE: -1 INCHI: InChI=1S/C14H21NO11/c1-4(17)15-8-11(10(20)7(3-16)24-13(8)23)26-14-9(19)5(18)2-6(25-14)12(21)22/h2,5,7-11,13-14,16,18-20,23H,3H2,1H3,(H,15,17)(H,21,22)/t5-,7+,8+,9+,10+,11+,13+,14-/m0/s1
has only substance units: false
initial amount: NaN
type: Species

http://identifiers.org/biomodels.db/MODEL1310110063#_b9aec470_539d_4550_a524_3a6ffadbe0e5
is: SBO:0000252
initial concentration: NaN
initial amount: NaN
has only substance units: false
constant: false
boundary condition: true
is encoded by: hsa:54898
type: Species
is: Q9NXB9
name: ELOVL2

metaM akg x
initial amount: NaN
is: CHEBI:16810
boundary condition: false
initial concentration: 1.0
name: 2-oxoglutarate(2-)
has only substance units: false
constant: false
type: Species
is: SBO:0000247
is: HMDB00208
notes: FORMULA: C5H4O5 CHARGE: -2 INCHI: InChI=1S/C5H6O5/c6-3(5(9)10)1-2-4(7)8/h1-2H2,(H,7,8)(H,9,10)/p-2 HEPATONET_1.0_ABBREVIATION: HC00035 EHMN_ABBREVIATION: C00026

http://identifiers.org/biomodels.db/MODEL1310110063#_de6a5ecf_2638_4362_876f_38842f9035ec
constant: false
is: Q14442
is: SBO:0000252
has only substance units: false
initial amount: NaN
name: PIGH
initial concentration: NaN
boundary condition: true
is encoded by: hsa:5283
type: Species

http://identifiers.org/biomodels.db/MODEL1310110063#_11292b54_de8f_4e86_8ae0_38e7c783ed44
is encoded by: hsa:522
has only substance units: false
name: ATP5J
boundary condition: true
type: Species
constant: false
initial concentration: NaN
is: Q6IB54
initial amount: NaN
is: SBO:0000252

metaM pe hs m
is: CHEBI:16038
initial concentration: 1.0
notes: FORMULA: C5H12NO4PFULLRCO2FULLR2CO2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC02002 EHMN_ABBREVIATION: C00350
has only substance units: false
name: phosphatidylethanolamine
constant: false
initial amount: NaN
type: Species
is: SBO:0000247
boundary condition: false

metaM ala D e
type: Species
initial concentration: 1.0
constant: false
is: CHEBI:15570
is: SBO:0000247
name: D-alanine
initial amount: NaN
has only substance units: false
notes: FORMULA: C3H7NO2 CHARGE: 0 INCHI: InChI=1S/C3H7NO2/c1-2(4)3(5)6/h2H,4H2,1H3,(H,5,6)/t2-/m1/s1
is: HMDB01310
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110063#_7ed61209_d7ed_4e5e_aa71_76a1e6a7ede9
boundary condition: true
initial concentration: NaN
type: Species
name: ALDH3A1
is encoded by: hsa:218
constant: false
is: SBO:0000252
initial amount: NaN
is: P30838
has only substance units: false

metaR ALAGLYexR
kinetic law: MODEL1310110063#
reactant: MODEL1310110063#
type: Reaction
name: L-alanine/glycine reversible exchange
fast: false
product: MODEL1310110063#
modifier: MODEL1310110063#
notes: GENE_ASSOCIATION: (56301.1) and (6520.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10734121,PMID:10863037,PMID:14770310 NOTES:
reversible: true
is: SBO:0000185
is described by: ECO:0000304

metaM cs a deg2 l
constant: false
initial concentration: 1.0
is: HMDB00127
name: chondroitin sulfate A (GalNAc4S-GlcA), degradation product 2
type: Species
is: SBO:0000247
boundary condition: false
initial amount: NaN
notes: FORMULA: C37H55NO38S2 CHARGE: -4
has only substance units: false
is: CHEBI:15748

http://identifiers.org/biomodels.db/MODEL1310110063#_9a705506_2fa2_45e5_923e_5bd04e69f5ec
has only substance units: false
boundary condition: true
initial concentration: NaN
is encoded by: hsa:11282
initial amount: NaN
is: SBO:0000252
name: MGAT4B
constant: false
type: Species

metaM 34dhoxmand m
initial concentration: 1.0
is: HMDB01866
initial amount: NaN
constant: false
is: CHEBI:27637
has only substance units: false
notes: FORMULA: C8H7O5 CHARGE: -1 INCHI: InChI=1S/C8H8O5/c9-5-2-1-4(3-6(5)10)7(11)8(12)13/h1-3,7,9-11H,(H,12,13) HEPATONET_1.0_ABBREVIATION: HC01517 EHMN_ABBREVIATION: C05580
type: Species
boundary condition: false
is: SBO:0000247
name: 3,4-Dihydroxymandelate

metaR r0281
name: Putrescine:oxygen oxidoreductase (deaminating) Urea cycle and metabolism of amino groups EC:1.4.3.6
reactant: MODEL1310110063#
is: SBO:0000176
modifier: MODEL1310110063#
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/5.3.1.6
reversible: true
notes: GENE_ASSOCIATION: (22934.1) SUBSYSTEM: Methionine and cysteine metabolism EC Number: 1.4.3.6 Confidence Level: 0 AUTHORS: PMID:12072962,PMID:15795708,PMID:17006978,PMID:6403048 NOTES:
product: MODEL1310110063#
type: Reaction
kinetic law: MODEL1310110063#
fast: false

metaM acgam r
type: Species
notes: FORMULA: C8H15NO6 CHARGE: 0 INCHI: InChI=1S/C8H15NO6/c1-4(12)9-5(2-10)7(14)8(15)6(13)3-11/h2,5-8,11,13-15H,3H2,1H3,(H,9,12)/t5-,6+,7+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00138 EHMN_ABBREVIATION: C00140
is: HMDB00215
initial amount: NaN
constant: false
initial concentration: 1.0
is: CHEBI:17411
boundary condition: false
name: N-acetyl-D-glucosamine
is: SBO:0000247
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110063#_037dc886_9f5a_40a9_b8f5_54c9d2e3d706
constant: false
has only substance units: false
is: SBO:0000252
initial amount: NaN
type: Species
initial concentration: NaN
boundary condition: true
name: AMPD2
is encoded by: hsa:271
is: E9PNG0

metaR r0403
name: L-Tryptophan,tetrahydrobiopterin:oxygen oxidoreductase (5-hydroxylating) Tryptophan metabolism EC:1.14.16.4
kinetic law: MODEL1310110063#
type: Reaction
modifier: MODEL1310110063#
product: MODEL1310110063#
is version of: http://identifiers.org/ec-code/1.2.4.4
reversible: true
fast: false
is described by: ECO:0000000
reactant: MODEL1310110063#
is: SBO:0000176
notes: GENE_ASSOCIATION: (594.1) or (641649.1) SUBSYSTEM: Tetrahydrobiopterin metabolism EC Number: 1.14.16.4 Confidence Level: 0 AUTHORS: NOTES:

metaM tag hs c
type: Species
is: CHEBI:17855
notes: FORMULA: C3H5FULLRCO2FULLR2CO2FULLR3CO2 CHARGE: 0
is: SBO:0000247
constant: false
initial concentration: 1.0
boundary condition: false
has only substance units: false
name: triglyceride
initial amount: NaN

metaR EX nrvnc LPAREN e RPAREN
kinetic law: MODEL1310110063#
reactant: MODEL1310110063#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: nervonic acid exchange
type: Reaction

metaR SERASNNaEx
product: MODEL1310110063#
notes: GENE_ASSOCIATION: (6510.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14530974 NOTES:SAB see Kanai and Hediger 2004 (2003), PMID 14530974
reversible: false
kinetic law: MODEL1310110063#
name: L-serine/L-asparagine Na-dependent exchange (Ser-L in)
reactant: MODEL1310110063#
type: Reaction
is described by: ECO:0000269
fast: false
is: SBO:0000185
modifier: MODEL1310110063#

metaR EX n2m2nmasn LPAREN e RPAREN
kinetic law: MODEL1310110063#
reactant: MODEL1310110063#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: N-Acetyl-beta-D-glucosaminyl-1,2-alpha-D-mannosyl-1,3-(N-acetyl-beta-D-glucosaminyl-1,2-alpha-D-mannosyl-1,6)-(N-acetyl-beta-D-glucosaminyl-1,4)-beta-D-mannosyl-1,4-N-acetyl-beta-D-glucosaminyl-R exchange
type: Reaction

metaM HC01459 x
has only substance units: false
is: CHEBI:27458
is: SBO:0000247
boundary condition: false
constant: false
type: Species
name: 3alpha,7alpha,12alpha,24-Tetrahydroxy-5beta-cholestanoyl-CoA
initial concentration: 1.0
notes: FORMULA: C48H76N7O21P3S CHARGE: -4 INCHI: InChI=1S/C48H80N7O21P3S/c1-24(28-8-9-29-36-30(19-34(59)48(28,29)6)47(5)13-11-27(56)17-26(47)18-32(36)58)7-10-31(57)25(2)45(64)80-16-15-50-35(60)12-14-51-43(63)40(62)46(3,4)21-73-79(70,71)76-78(68,69)72-20-33-39(75-77(65,66)67)38(61)44(74-33)55-23-54-37-41(49)52-22-53-42(37)55/h22-34,36,38-40,44,56-59,61-62H,7-21H2,1-6H3,(H,50,60)(H,51,63)(H,68,69)(H,70,71)(H2,49,52,53)(H2,65,66,67)/t24-,25?,26+,27-,28-,29+,30+,31?,32-,33-,34+,36+,38-,39-,40+,44-,47+,48-/m1/s1 EHMN_ABBREVIATION: C05450
initial amount: NaN

metaM xolest2 hs e
initial concentration: 1.0
has only substance units: false
boundary condition: false
type: Species
is: SBO:0000247
constant: false
notes: FORMULA: C27H45FULLR2CO2 CHARGE: 0
is: CHEBI:17002
initial amount: NaN
name: cholesterol ester

metaR EX 3hdececrn
kinetic law: MODEL1310110063#
reactant: MODEL1310110063#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for 3-hydroxyhexadecenoyl carnitine
type: Reaction

metaR PROD2m
name: Proline dehydrogenase (m)
product: MODEL1310110063#
reversible: false
reactant: MODEL1310110063#
notes: GENE_ASSOCIATION: (5625.1) SUBSYSTEM: Arginine and Proline Metabolism EC Number: 1.5.99.8 Confidence Level: 2 AUTHORS: PMID:10192398 NOTES:JLR SAB m
type: Reaction
is: SBO:0000176
fast: false
modifier: MODEL1310110063#
is version of: http://identifiers.org/ec-code/1.5.99.8
kinetic law: MODEL1310110063#
is described by: ECO:0000254

http://identifiers.org/biomodels.db/MODEL1310110063#_c301e9d6_9b6c_4532_a380_51e09674adbe
is: G3XAJ0
is: SBO:0000252
name: ACAD10
boundary condition: true
constant: false
initial amount: NaN
has only substance units: false
initial concentration: NaN
is encoded by: hsa:80724
type: Species

http://identifiers.org/biomodels.db/MODEL1310110063#_7392585f_3a8e_4013_a7b5_4c677844a811
has only substance units: false
has part: P18545
constant: false
is encoded by: hsa:5148
name: PDE6A:PDE6C:PDE6D:PDE6G:PDE6B
is encoded by: hsa:5147
initial amount: NaN
boundary condition: true
is: SBO:0000297
initial concentration: NaN
type: Species
has part: O43924

http://identifiers.org/biomodels.db/MODEL1310110063#_8ee0c6b2_4325_4a40_83e2_c8ce36031b60
boundary condition: true
name: ABP1
is encoded by: hsa:26
is: P19801
type: Species
has only substance units: false
initial amount: NaN
constant: false
initial concentration: NaN
is: SBO:0000252

metaM apoC c
is: SBO:0000247
initial amount: NaN
notes: FORMULA: XH CHARGE: 0
has only substance units: false
type: Species
initial concentration: 1.0
is: CHEBI:33190
is: HMDB11111
name: Apocarboxlase (no lys residue)
boundary condition: false
constant: false

metaM atp x
initial concentration: 1.0
initial amount: NaN
type: Species
is: C00002
is: SBO:0000247
has only substance units: false
is: HMDB00538
boundary condition: false
is: CHEBI:57299
constant: false
name: ATP(4-)

http://identifiers.org/biomodels.db/MODEL1310110063#_6721fd0c_8c45_49d2_91e3_44a24fa62b04
type: Species
constant: false
is: G3XA95
is: SBO:0000252
initial amount: NaN
has only substance units: false
boundary condition: true
name: PPAP2A
initial concentration: NaN
is encoded by: hsa:8611

metaR CERT1rt
fast: false
notes: GENE_ASSOCIATION: (10087.1) SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: PMID:12803919,PMID:14685229,PMID:15596449,PMID:15907394 NOTES:non-vesicular intracellular transport of ceramide
modifier: MODEL1310110063#
kinetic law: MODEL1310110063#
is version of: http://identifiers.org/ec-code/2.7.11.1
is described by: ECO:0000304
reactant: MODEL1310110063#
product: MODEL1310110063#
reversible: true
is: SBO:0000185
name: ceramide transport protein
type: Reaction

metaR r2079
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
fast: false
product: MODEL1310110063#
is described by: ECO:0000000
type: Reaction
reversible: true
reactant: MODEL1310110063#
kinetic law: MODEL1310110063#
is: SBO:0000185
modifier: MODEL1310110063#

metaM hexccoa x
notes: FORMULA: C47H82N7O17P3S CHARGE: -4 INCHI: InChI=1/C47H86N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-24-25-26-27-38(56)75-31-30-49-37(55)28-29-50-45(59)42(58)47(2,3)33-68-74(65,66)71-73(63,64)67-32-36-41(70-72(60,61)62)40(57)46(69-36)54-35-53-39-43(48)51-34-52-44(39)54/h34-36,40-42,46,57-58H,4-33H2,1-3H3,(H,49,55)(H,50,59)(H,63,64)(H,65,66)(H2,48,51,52)(H2,60,61,62)/p-4/t36-,40-,41-,42+,46-/m1/s1
type: Species
initial amount: NaN
boundary condition: false
has only substance units: false
is: SBO:0000247
initial concentration: 1.0
constant: false
name: Hexacosanoyl-CoA (n-C26:0CoA)
is: HMDB06459

metaM CE2435 m
notes: FORMULA: C31H46N7O17P3S CHARGE: -4 INCHI: InChI=1/C31H50N7O17P3S/c1-4-5-6-7-8-9-10-11-22(40)59-15-14-33-21(39)12-13-34-29(43)26(42)31(2,3)17-52-58(49,50)55-57(47,48)51-16-20-25(54-56(44,45)46)24(41)30(53-20)38-19-37-23-27(32)35-18-36-28(23)38/h8-11,18-20,24-26,30,41-42H,4-7,12-17H2,1-3H3,(H,33,39)(H,34,43)(H,47,48)(H,49,50)(H2,32,35,36)(H2,44,45,46)/p-4/b9-8-,11-10+/t20-,24+,25+,26u,30-/m0/s1 EHMN_ABBREVIATION: CE2435
is: SBO:0000247
has only substance units: false
name: trans,cis-deca-2,4-dienoyl-CoA
constant: false
initial amount: NaN
boundary condition: false
initial concentration: 1.0
is: CHEBI:57795
type: Species

metaM acgam l
is: CHEBI:17411
is: HMDB00215
initial concentration: 1.0
type: Species
has only substance units: false
constant: false
boundary condition: false
initial amount: NaN
notes: FORMULA: C8H15NO6 CHARGE: 0 INCHI: InChI=1S/C8H15NO6/c1-4(12)9-5(2-10)7(14)8(15)6(13)3-11/h2,5-8,11,13-15H,3H2,1H3,(H,9,12)/t5-,6+,7+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00138 EHMN_ABBREVIATION: C00140
is: SBO:0000247
name: N-acetyl-D-glucosamine

http://identifiers.org/biomodels.db/MODEL1310110063#_e337946a_e0f9_474a_b7c7_d592e7d8b312
is: SBO:0000252
name: SLC28A3
boundary condition: true
initial amount: NaN
type: Species
has only substance units: false
is encoded by: hsa:64078
is: Q9HAS3
initial concentration: NaN
constant: false

metaR r2139
reactant: MODEL1310110063#
fast: false
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
reversible: true
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.14
is described by: ECO:0000000
type: Reaction
kinetic law: MODEL1310110063#
product: MODEL1310110063#
modifier: MODEL1310110063#
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110063#_8def9624_7a55_4f00_b8b7_ec4bbbb478aa
is encoded by: hsa:498
is: SBO:0000252
initial amount: NaN
is: A8K092
boundary condition: true
name: ATP5A1
type: Species
has only substance units: false
initial concentration: NaN
constant: false

metaM CE5236 n
type: Species
is: SBO:0000247
initial concentration: 1.0
is: HMDB03952
has only substance units: false
initial amount: NaN
constant: false
notes: FORMULA: C9H13N5O3 CHARGE: 0 INCHI: InChI=1/C9H13N5O3/c1-3-5(15)4-2-11-6-9(14-4,17-3)7(16)13-8(10)12-6/h3-5,14-15H,2H2,1H3,(H3,10,11,12,13,16)/p+1/t3-,4u,5+,9u/m0/s1 EHMN_ABBREVIATION: CE5236
is: CHEBI:28002
name: O2'-4a-cyclic-tetrahydrobiopterin
boundary condition: false

metaR r1650
reversible: true
fast: false
modifier: MODEL1310110063#
is: SBO:0000185
reactant: MODEL1310110063#
type: Reaction
kinetic law: MODEL1310110063#
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
product: MODEL1310110063#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is described by: ECO:0000000

metaR PRISTANALtx
name: pristanal peroxisomal transport
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 1 AUTHORS: NOTES:Mechanism not known, see PMID 11591435 for justification. NJ
kinetic law: MODEL1310110063#
reactant: MODEL1310110063#
fast: false
is: SBO:0000185
reversible: true
product: MODEL1310110063#
is described by: ECO:0000000
type: Reaction

metaR EX atp LPAREN e RPAREN
kinetic law: MODEL1310110063#
reactant: MODEL1310110063#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: ATP exchange
type: Reaction

metaR EX doco13ac
kinetic law: MODEL1310110063#
reactant: MODEL1310110063#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for docosenoic acid (C22:1)
type: Reaction

metaR RE1804M
reactant: MODEL1310110063#
reversible: true
type: Reaction
product: MODEL1310110063#
modifier: MODEL1310110063#
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/1.14.13.15
is: SBO:0000176
kinetic law: MODEL1310110063#
notes: GENE_ASSOCIATION: (1593.1) SUBSYSTEM: Bile acid synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:9660774 NOTES:
fast: false
name: RE1804

metaR EX 5mthf LPAREN e RPAREN
kinetic law: MODEL1310110063#
reactant: MODEL1310110063#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for 5-Methyltetrahydrofolate
type: Reaction

metaR BUP2
name: beta-ureidopropionase (D-3-amino-isobutanoate forming)
fast: false
reactant: MODEL1310110063#
reversible: false
kinetic law: MODEL1310110063#
is described by: ECO:0000269
is: SBO:0000176
type: Reaction
is version of: http://identifiers.org/ec-code/3.5.1.6
notes: GENE_ASSOCIATION: (51733.1) SUBSYSTEM: Pyrimidine catabolism EC Number: 3.5.1.6 Confidence Level: 4 AUTHORS: PMID:11508704,PMID:5773299 NOTES:MM
modifier: MODEL1310110063#
product: MODEL1310110063#

http://identifiers.org/biomodels.db/MODEL1310110063#_a8b44faa_5c76_4662_91fd_e688f93b0800
constant: false
is: E7EPA7
is: SBO:0000252
boundary condition: true
is encoded by: hsa:7086
type: Species
name: TKT
initial amount: NaN
has only substance units: false
initial concentration: NaN

metaR DRPA
fast: false
name: deoxyribose-phosphate aldolase
type: Reaction
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Pentose phosphate pathway EC Number: 4.1.2.4 Confidence Level: 2 AUTHORS: NOTES:
reversible: false
kinetic law: MODEL1310110063#
reactant: MODEL1310110063#
is described by: ECO:0000000
product: MODEL1310110063#

metaM gal l
is: HMDB00143
is: CHEBI:12936
has only substance units: false
initial amount: NaN
boundary condition: false
notes: FORMULA: C6H12O6 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00122 EHMN_ABBREVIATION: C00124
constant: false
initial concentration: 1.0
type: Species
is: SBO:0000247
name: D-galactose

metaR TIGCRNe
kinetic law: MODEL1310110063#
product: MODEL1310110063#
reactant: MODEL1310110063#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of tiglyl carnitine into the extra cellular fluid
type: Reaction

metaM ala D c
boundary condition: false
is: CHEBI:15570
initial amount: NaN
is: HMDB01310
has only substance units: false
notes: FORMULA: C3H7NO2 CHARGE: 0 INCHI: InChI=1S/C3H7NO2/c1-2(4)3(5)6/h2H,4H2,1H3,(H,5,6)/t2-/m1/s1
name: D-alanine
is: SBO:0000247
type: Species
initial concentration: 1.0
constant: false

metaR BUTt2r
kinetic law: MODEL1310110063#
modifier: MODEL1310110063#
product: MODEL1310110063#
type: Reaction
fast: false
is described by: ECO:0000269
reversible: true
is: SBO:0000185
notes: GENE_ASSOCIATION: (6566.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10510291,PMID:11827462,PMID:12739169,PMID:7835905,PMID:8476015,PMID:9508842,PMID:9649795,PMID:9824713 NOTES:JLR
name: Butyrate transport via proton symport, reversible
reactant: MODEL1310110063#

metaM m1mpdol U c
initial amount: NaN
is: CHEBI:28067
notes: FORMULA: C1305H2140N20O270P20 CHARGE: -20 INCHI: InChI=1S/C53H92N2O27P2/c1-27(2)13-9-14-28(3)15-10-16-29(4)17-11-18-30(5)19-12-20-31(6)21-22-73-83(69,70)82-84(71,72)81-51-39(55-33(8)61)43(65)47(37(26-59)77-51)78-50-38(54-32(7)60)42(64)48(36(25-58)76-50)79-53-46(68)49(41(63)35(24-57)75-53)80-52-45(67)44(66)40(62)34(23-56)74-52/h13,15,17,19,31,34-53,56-59,62-68H,9-12,14,16,18,20-26H2,1-8H3,(H,54,60)(H,55,61)(H,69,70)(H,71,72)/b28-15+,29-17+,30-19+/t31?,34-,35-,36-,37-,38-,39-,40-,41-,42-,43-,44+,45+,46+,47-,48-,49+,50+,51-,52-,53+/m1/s1
name: alpha-D-mannosyl-beta-D-mannosyl-diacylchitobiosyldiphosphodolichol, human uterine homolog
type: Species
constant: false
has only substance units: false
boundary condition: false
is: SBO:0000247
initial concentration: 1.0

metaM pydxn c
has only substance units: false
is: C00314
type: Species
boundary condition: false
initial concentration: 1.0
notes: FORMULA: C8H11NO3 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00268 EHMN_ABBREVIATION: C00314
is: CHEBI:16709
initial amount: NaN
is: SBO:0000247
is: HMDB00239
name: Pyridoxine
constant: false

metaM hom L c
initial concentration: 1.0
is: CHEBI:15699
is: HMDB00719
is: SBO:0000247
boundary condition: false
type: Species
name: L-homoserine
has only substance units: false
initial amount: NaN
notes: FORMULA: C4H9NO3 CHARGE: 0 INCHI: InChI=1S/C4H9NO3/c5-3(1-2-6)4(7)8/h3,6H,1-2,5H2,(H,7,8)/t3-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00239
constant: false

metaR DECDPtm
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: PMID:12840657 NOTES:ubiquinone precursor, transport by "diffusion" -> actually beleived to be flip-flop mechanism (PMID: 12840657). NJ
reversible: true
product: MODEL1310110063#
fast: false
is: SBO:0000185
kinetic law: MODEL1310110063#
name: lipid, flip-flop intracellular transport
type: Reaction
reactant: MODEL1310110063#
is described by: ECO:0000000

metaM ca2 e
has only substance units: false
type: Species
name: calcium(2+)
initial concentration: 1.0
is: SBO:0000247
boundary condition: false
is: CHEBI:29108
is: HMDB00464
constant: false
notes: FORMULA: Ca CHARGE: 2 INCHI: InChI=1S/Ca/q+2 EHMN_ABBREVIATION: C00076
initial amount: NaN

metaR DRBK
name: Deoxyribokinase
is: SBO:0000176
type: Reaction
notes: GENE_ASSOCIATION: (64080.1) SUBSYSTEM: Pentose phosphate pathway EC Number: 2.7.1.15 Confidence Level: 2 AUTHORS: PMID:9693094 NOTES:NCD
is described by: ECO:0000304
reversible: false
fast: false
product: MODEL1310110063#
modifier: MODEL1310110063#
is version of: http://identifiers.org/ec-code/2.7.1.15
reactant: MODEL1310110063#
kinetic law: MODEL1310110063#

http://identifiers.org/biomodels.db/MODEL1310110063#_710546be_9756_445d_8d64_aecde94a3028
name: SLC2A12
is encoded by: hsa:154091
has only substance units: false
initial concentration: NaN
is: SBO:0000252
type: Species
initial amount: NaN
is: Q8TD20
boundary condition: true
constant: false

http://identifiers.org/biomodels.db/MODEL1310110063#_fb4f2640_aabd_4a3b_b1e0_479a984a281b
type: Species
is encoded by: hsa:221
has only substance units: false
initial amount: NaN
is: P43353
is: SBO:0000252
initial concentration: NaN
constant: false
boundary condition: true
name: ALDH3B1

metaM hs deg12 l
has only substance units: false
is: HMDB01352
type: Species
is: CHEBI:17180
initial amount: NaN
notes: FORMULA: C55H82N3O64S6 CHARGE: -7
is: SBO:0000247
constant: false
name: heparan sulfate, degradation product 12
boundary condition: false
initial concentration: 1.0

metaR r2137
name: Major Facilitator(MFS) TCDB:2.A.1.14.6
modifier: MODEL1310110063#
is: SBO:0000185
product: MODEL1310110063#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12811560 NOTES:
reactant: MODEL1310110063#
kinetic law: MODEL1310110063#
is described by: ECO:0000000
type: Reaction
fast: false
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110063#_1b241e25_ab3a_4dbc_bbbc_064d3c5005e0
is: F6KD01
has only substance units: false
type: Species
is encoded by: hsa:5728
name: PTEN
initial amount: NaN
initial concentration: NaN
is: SBO:0000252
constant: false
boundary condition: true

metaR RDH1
is version of: http://identifiers.org/ec-code/1.1.1.315
notes: GENE_ASSOCIATION: (5959.1) or (8608.1) SUBSYSTEM: Vitamin A metabolism EC Number: 1.1.1.105 Confidence Level: 4 AUTHORS: PMID:10329026,PMID:12226107,PMID:12534290,PMID:1503811 NOTES:IT
type: Reaction
reversible: true
name: retinol dehydrogenase (all-trans)
modifier: MODEL1310110063#
is described by: ECO:0000269
product: MODEL1310110063#
kinetic law: MODEL1310110063#
reactant: MODEL1310110063#
fast: false
is: SBO:0000176

metaR r1652
is: SBO:0000185
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
fast: false
reactant: MODEL1310110063#
type: Reaction
reversible: true
modifier: MODEL1310110063#
kinetic law: MODEL1310110063#
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is described by: ECO:0000000
product: MODEL1310110063#

metaR GLCURtly
kinetic law: MODEL1310110063#
type: Reaction
reversible: true
modifier: MODEL1310110063#
reactant: MODEL1310110063#
fast: false
notes: GENE_ASSOCIATION: (26503.1) SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 4 AUTHORS: PMID:10581036,PMID:2768261 NOTES:H symport into lysososome. See PMID: 2768261 and PMID: 10581036 ( for human evidence). Sialic acid storage disorders (due to transporter mutations) require import and export e.g. PMID: 2768266 NJ renamed from GLCURlt to GLCURtly - NCD
is: SBO:0000185
product: MODEL1310110063#
is described by: ECO:0000269
name: glucuronate transport into lysososme

metaR r0407
notes: GENE_ASSOCIATION: (AI934540.1) or (55163.1) or (W74642.1) SUBSYSTEM: Unassigned EC Number: 4.1.2.13 Confidence Level: 0 AUTHORS: PMID:10214945,PMID:2198022,PMID:4052378,PMID:4084320,PMID:6952783 NOTES:
type: Reaction
fast: false
is version of: http://identifiers.org/ec-code/1.4.3.5
reversible: true
modifier: MODEL1310110063#
is described by: ECO:0000000
reactant: MODEL1310110063#
is: SBO:0000176
product: MODEL1310110063#
kinetic law: MODEL1310110063#
name: Sedoheptulose 1,7-bisphosphate D-glyceraldehyde-3-phosphate-lyase Carbon fixation EC:4.1.2.13

metaR RE3243R
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (64834.1) SUBSYSTEM: Fatty acid synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:10970790,PMID:11567032,PMID:2114179 NOTES:
reactant: MODEL1310110063#
type: Reaction
product: MODEL1310110063#
modifier: MODEL1310110063#
fast: false
reversible: true
name: RE3243
is: SBO:0000176
kinetic law: MODEL1310110063#

metaM 3mldz c
is: HMDB04181
constant: false
initial concentration: 1.0
name: 1-methylimidazole-4-acetaldehyde
is: SBO:0000247
notes: FORMULA: C6H8N2O CHARGE: 0 INCHI: InChI=1S/C6H8N2O/c1-8-4-6(2-3-9)7-5-8/h3-5H,2H2,1H3 EHMN_ABBREVIATION: C05827
type: Species
boundary condition: false
has only substance units: false
initial amount: NaN
is: CHEBI:28104

metaR OCCOAtx
reactant: MODEL1310110063#
name: fatty acid intracellular transport
reversible: true
product: MODEL1310110063#
type: Reaction
kinetic law: MODEL1310110063#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: NOTES:interaction between peroxisomes and ER (some enzymes on the outer membrane) NJ
fast: false
is: SBO:0000185
is described by: ECO:0000000

metaM acnam l
is: HMDB00230
is: CHEBI:35418
boundary condition: false
has only substance units: false
type: Species
initial concentration: 1.0
notes: FORMULA: C11H18NO9 CHARGE: -1 INCHI: InChI=1S/C11H19NO9/c1-4(14)12-7-5(15)2-11(20,10(18)19)21-9(7)8(17)6(16)3-13/h5-9,13,15-17,20H,2-3H2,1H3,(H,12,14)(H,18,19)/p-1/t5-,6+,7+,8+,9+,11?/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00244 EHMN_ABBREVIATION: C00270
initial amount: NaN
is: SBO:0000247
constant: false
name: N-acetylneuraminate

metaR PDE4
modifier: MODEL1310110063#
name: 3',5'-cyclic-nucleotide phosphodiesterase
type: Reaction
is: SBO:0000176
product: MODEL1310110063#
is version of: http://identifiers.org/ec-code/3.1.4.35
reversible: false
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/3.1.4.17
kinetic law: MODEL1310110063#
fast: false
notes: GENE_ASSOCIATION: (5139.1) or (5146.1) or (5152.17) or (50940.1) or (5152.6) or (5136.1) or (5152.11) or (5152.2) or (8654.2) or (10846.1) or (5152.10) or (5145.1 and 5158.1 and 5149.1) or (5140.1) or (5152.12) or (5152.15) or (5137.1) or (5136.2) or (5138.1) or (5152.5) or (5153.1) or (5152.20) or (5152.19) or (5152.16) or (8654.3) or (5152.14) or (5152.13) or (5152.7) or (5152.3) or (5140.2) or (8654.1) or (5152.18) or (5145.1 and 5146.1 and 5158.1 and 5147.1 and 5148.1) or (5152.4) SUBSYSTEM: Nucleotide interconversion EC Number: 3.1.4.17 Confidence Level: 4 AUTHORS: PMID:10952971,PMID:12038792,PMID:12135876,PMID:12154085,PMID:12565835,PMID:14527714,PMID:14604994,PMID:15147193,PMID:15272012,PMID:15480303,PMID:8786098,PMID:8884271,PMID:9210593,PMID:9419816,PMID:9624146,PMID:9716380 NOTES:NCD
reactant: MODEL1310110063#

http://identifiers.org/biomodels.db/MODEL1310110063#_d3458126_c7f6_494a_9692_fd103840c37b
is: E9PB82
initial amount: NaN
has only substance units: false
initial concentration: NaN
is: SBO:0000252
name: HSD17B4
boundary condition: true
type: Species
is encoded by: hsa:3295
constant: false

metaR r2136
is described by: ECO:0000000
reactant: MODEL1310110063#
type: Reaction
reversible: false
kinetic law: MODEL1310110063#
modifier: MODEL1310110063#
fast: false
name: Major Facilitator(MFS) TCDB:2.A.1.14.6
is: SBO:0000185
product: MODEL1310110063#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12811560 NOTES:

metaM acnam n
is: HMDB00230
type: Species
initial concentration: 1.0
has only substance units: false
name: N-acetylneuraminate
constant: false
is: SBO:0000247
initial amount: NaN
boundary condition: false
notes: FORMULA: C11H18NO9 CHARGE: -1 INCHI: InChI=1S/C11H19NO9/c1-4(14)12-7-5(15)2-11(20,10(18)19)21-9(7)8(17)6(16)3-13/h5-9,13,15-17,20H,2-3H2,1H3,(H,12,14)(H,18,19)/p-1/t5-,6+,7+,8+,9+,11?/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00244 EHMN_ABBREVIATION: C00270
is: CHEBI:35418

metaR r0408
reversible: true
product: MODEL1310110063#
type: Reaction
fast: false
modifier: MODEL1310110063#
name: ATP:Sedoheptulose 7-phosphate 1-phosphotransferase EC:2.7.1.11
reactant: MODEL1310110063#
is version of: http://identifiers.org/ec-code/1.4.3.5
kinetic law: MODEL1310110063#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (AI934540.1) or (55163.1) or (W74642.1) SUBSYSTEM: Unassigned EC Number: 2.7.1.11 Confidence Level: 0 AUTHORS: PMID:4084320,PMID:4272358 NOTES:
is: SBO:0000176

metaR RDH2
is: SBO:0000176
product: MODEL1310110063#
notes: GENE_ASSOCIATION: (5959.1) SUBSYSTEM: Vitamin A metabolism EC Number: 1.1.1.105 Confidence Level: 4 AUTHORS: PMID:12226107,PMID:1503811,PMID:7836368,PMID:9115228 NOTES:IT
reversible: true
type: Reaction
reactant: MODEL1310110063#
modifier: MODEL1310110063#
name: retinol dehydrogenase (9-cis,NADH)
kinetic law: MODEL1310110063#
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/1.1.1.315
fast: false

metaR C142CPT1
kinetic law: MODEL1310110063#
product: MODEL1310110063#
reactant: MODEL1310110063#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: production of tetradecadienoylcarnitine
type: Reaction

metaR r1651
product: MODEL1310110063#
modifier: MODEL1310110063#
type: Reaction
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is: SBO:0000185
fast: false
reactant: MODEL1310110063#
is described by: ECO:0000000
kinetic law: MODEL1310110063#
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110063#_42ae0939_5ab3_4acf_a1f2_36cbc05426bb
type: Species
is: SBO:0000252
is: P48651
name: PTDSS1
boundary condition: true
initial concentration: NaN
initial amount: NaN
constant: false
has only substance units: false
is encoded by: hsa:9791

metaM hom L e
initial concentration: 1.0
is: CHEBI:15699
is: SBO:0000247
is: HMDB00719
initial amount: NaN
type: Species
boundary condition: false
constant: false
notes: FORMULA: C4H9NO3 CHARGE: 0 INCHI: InChI=1S/C4H9NO3/c5-3(1-2-6)4(7)8/h3,6H,1-2,5H2,(H,7,8)/t3-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00239
name: L-homoserine
has only substance units: false

metaR r0173
type: Reaction
notes: GENE_ASSOCIATION: (3704.1) SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: 1.1.1.27 Confidence Level: 0 AUTHORS: PMID:12042361,PMID:17045662,PMID:7449128,PMID:9927705 NOTES:
modifier: MODEL1310110063#
reversible: true
name: (S)-Lactate:NAD+ oxidoreductase Glycolysis / Gluconeogenesis / Pyruvate metabolism EC:1.1.1.27
fast: false
kinetic law: MODEL1310110063#
reactant: MODEL1310110063#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.6.1.19
is described by: ECO:0000000
product: MODEL1310110063#

metaM hs deg20 l
notes: FORMULA: C45H68N2O43S2 CHARGE: -4
initial concentration: 1.0
initial amount: NaN
boundary condition: false
is: SBO:0000247
has only substance units: false
constant: false
is: CHEBI:16126
name: heparan sulfate, degradation product 20
type: Species

http://identifiers.org/biomodels.db/MODEL1310110063#_e98790dc_4378_4d62_900d_379b7c66936b
initial amount: NaN
is: SBO:0000252
constant: false
initial concentration: NaN
has only substance units: false
is: P43251
boundary condition: true
type: Species
is encoded by: hsa:686
name: BTD

http://identifiers.org/biomodels.db/MODEL1310110063#_a682bfc7_3f59_4558_840b_14647df13bfa
name: _AF080579_1_c
has only substance units: false
type: Species
initial concentration: NaN
constant: false
is: SBO:0000252
is encoded by: hsa:AF080579
boundary condition: true
initial amount: NaN

metaM cmpacna n
is: SBO:0000247
initial concentration: 1.0
constant: false
has only substance units: false
boundary condition: false
is: HMDB01176
initial amount: NaN
is: CHEBI:57812
type: Species
notes: FORMULA: C20H29N4O16P CHARGE: -2 INCHI: InChI=1S/C20H31N4O16P/c1-7(26)22-12-8(27)4-20(18(32)33,39-16(12)13(29)9(28)5-25)40-41(35,36)37-6-10-14(30)15(31)17(38-10)24-3-2-11(21)23-19(24)34/h2-3,8-10,12-17,25,27-31H,4-6H2,1H3,(H,22,26)(H,32,33)(H,35,36)(H2,21,23,34)/p-2/t8-,9+,10+,12+,13+,14+,15+,16+,17+,20+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00126 EHMN_ABBREVIATION: C00128
name: CMP-N-acetyl-beta-neuraminate(2-)

http://identifiers.org/biomodels.db/MODEL1310110063#_53073e5d_08b6_4781_975f_5182b20dcb18
type: Species
is: P37268
is: SBO:0000252
is encoded by: hsa:2222
has only substance units: false
initial concentration: NaN
name: FDFT1
initial amount: NaN
boundary condition: true
constant: false

metaM ca2 c
name: calcium(2+)
initial concentration: 1.0
type: Species
initial amount: NaN
boundary condition: false
is: SBO:0000247
is: CHEBI:29108
notes: FORMULA: Ca CHARGE: 2 INCHI: InChI=1S/Ca/q+2 EHMN_ABBREVIATION: C00076
is: HMDB00464
has only substance units: false
constant: false

http://identifiers.org/biomodels.db/MODEL1310110063#_dc33e68e_acd9_415e_a2f9_6b14c0feff17
has only substance units: false
constant: false
is: SBO:0000252
initial concentration: NaN
is encoded by: hsa:6487
type: Species
initial amount: NaN
boundary condition: true
name: ST3GAL3

metaR DCSPTN1COAtx
fast: false
reversible: true
name: fatty acid intracellular transport
kinetic law: MODEL1310110063#
is: SBO:0000185
product: MODEL1310110063#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: NOTES:interaction between peroxisomes and ER (some enzymes on the outer membrane) NJ
is described by: ECO:0000000
reactant: MODEL1310110063#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110063#_03567ec0_abb0_4d9a_843e_85f4bf16c566
is encoded by: hsa:8801
has part: Q96I99
name: SUCLG2:SUCLG1
has only substance units: false
initial amount: NaN
initial concentration: NaN
is: SBO:0000297
is encoded by: hsa:8802
has part: P53597
boundary condition: true
constant: false
type: Species

metaR r1654
reactant: MODEL1310110063#
type: Reaction
fast: false
kinetic law: MODEL1310110063#
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
product: MODEL1310110063#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is described by: ECO:0000000
reversible: true
modifier: MODEL1310110063#
is: SBO:0000185

metaR EX retinol LPAREN e RPAREN
kinetic law: MODEL1310110063#
reactant: MODEL1310110063#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Retinol exchange
type: Reaction

metaM cs e deg1 l
boundary condition: false
initial concentration: 1.0
is: HMDB00868
initial amount: NaN
has only substance units: false
is: SBO:0000247
notes: FORMULA: C45H65N2O52S5 CHARGE: -7
constant: false
type: Species
is: CHEBI:57737
name: chondroitin sulfate E (GalNAc4,6diS-GlcA), degradation product 1

metaR EX dtdp LPAREN e RPAREN
kinetic law: MODEL1310110063#
reactant: MODEL1310110063#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: ({[(2R,3S,5R)-3-hydroxy-5-(5-methyl-2,4-dioxo-1,2,3,4-tetrahydropyrimidin-1-yl)oxolan-2-yl]methyl phosphonato}oxy)phosphonate exchange
type: Reaction

metaM 34dhoxmand c
name: 3,4-Dihydroxymandelate
type: Species
initial concentration: 1.0
notes: FORMULA: C8H7O5 CHARGE: -1 INCHI: InChI=1S/C8H8O5/c9-5-2-1-4(3-6(5)10)7(11)8(12)13/h1-3,7,9-11H,(H,12,13) HEPATONET_1.0_ABBREVIATION: HC01517 EHMN_ABBREVIATION: C05580
boundary condition: false
is: HMDB01866
is: CHEBI:27637
constant: false
is: SBO:0000247
initial amount: NaN
has only substance units: false

metaR THRASNNaEx
product: MODEL1310110063#
type: Reaction
modifier: MODEL1310110063#
reactant: MODEL1310110063#
name: L-threonine/L-asparagine Na-dependent exchange (Thr-L in)
fast: false
is: SBO:0000185
kinetic law: MODEL1310110063#
notes: GENE_ASSOCIATION: (6510.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14530974 NOTES:SAB see Kanai and Hediger 2004 (2003), PMID 14530974
reversible: false
is described by: ECO:0000269

metaR r0170
is version of: http://identifiers.org/ec-code/2.7.1.40
reactant: MODEL1310110063#
type: Reaction
kinetic law: MODEL1310110063#
name: Farnesyl-diphosphate:farnesyl-diphosphate farnesyltransferase Biosynthesis of steroids EC:2.5.1.21
product: MODEL1310110063#
notes: GENE_ASSOCIATION: (H77542.1) or (5313.1) or (5315.1) SUBSYSTEM: Cholesterol metabolism EC Number: 2.5.1.21 Confidence Level: 0 AUTHORS: PMID:11108725,PMID:1527001,PMID:17180682,PMID:7864626,PMID:8509416 NOTES:
fast: false
is: SBO:0000176
reversible: true
is described by: ECO:0000000
modifier: MODEL1310110063#

metaR BTNDm
is: SBO:0000176
reversible: false
modifier: MODEL1310110063#
name: biotinidase (biotin), mitochondrial
fast: false
is version of: http://identifiers.org/ec-code/3.5.1.12
reactant: MODEL1310110063#
type: Reaction
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (686.1) SUBSYSTEM: Biotin metabolism EC Number: 3.5.1.12 Confidence Level: 4 AUTHORS: PMID:12459313,PMID:15059618 NOTES:Also acts on biotin esters IT
product: MODEL1310110063#
kinetic law: MODEL1310110063#

metaM ethamp r
constant: false
notes: FORMULA: C2H7NO4P CHARGE: -1 INCHI: InChI=1S/C2H8NO4P/c3-1-2-7-8(4,5)6/h1-3H2,(H2,4,5,6)/p-1 HEPATONET_1.0_ABBREVIATION: HC00293 EHMN_ABBREVIATION: C00346
is: HMDB00224
type: Species
initial amount: NaN
is: CHEBI:58190
has only substance units: false
boundary condition: false
is: SBO:0000247
initial concentration: 1.0
name: O-phosphonatoethanaminium(1-)

metaR EX gluala LPAREN e RPAREN
kinetic law: MODEL1310110063#
reactant: MODEL1310110063#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 5-L-Glutamyl-L-alanine exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110063#_59b20f56_4f3d_468e_b21b_90180fd8ee4a
is: P00325
initial concentration: NaN
is encoded by: hsa:125
constant: false
has only substance units: false
name: ADH1B
type: Species
initial amount: NaN
is: SBO:0000252
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110063#_81ceadf5_e8f3_41ce_82e2_2313682e8249
is: SBO:0000252
boundary condition: true
has only substance units: false
is encoded by: hsa:3417
type: Species
constant: false
is: O75874
initial concentration: NaN
name: IDH1
initial amount: NaN

metaR r1653
modifier: MODEL1310110063#
type: Reaction
is: SBO:0000185
product: MODEL1310110063#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
fast: false
reactant: MODEL1310110063#
is described by: ECO:0000000
kinetic law: MODEL1310110063#
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reversible: true

metaM hdd2coa x
initial concentration: 1.0
name: (E)-hexadec-2-enoyl-CoA(4-)
is: CHEBI:61526
notes: FORMULA: C37H60N7O17P3S CHARGE: -4 INCHI: InChI=1S/C37H64N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-28(46)65-21-20-39-27(45)18-19-40-35(49)32(48)37(2,3)23-58-64(55,56)61-63(53,54)57-22-26-31(60-62(50,51)52)30(47)36(59-26)44-25-43-29-33(38)41-24-42-34(29)44/h16-17,24-26,30-32,36,47-48H,4-15,18-23H2,1-3H3,(H,39,45)(H,40,49)(H,53,54)(H,55,56)(H2,38,41,42)(H2,50,51,52)/p-4/b17-16+/t26-,30-,31-,32+,36-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01411 EHMN_ABBREVIATION: C05272
constant: false
type: Species
is: HMDB03945
initial amount: NaN
boundary condition: false
is: SBO:0000247
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110063#_59e7c37c_e7cd_4791_a4ac_55413b9edb68
initial concentration: NaN
constant: false
is: SBO:0000252
name: SLC2A9
is encoded by: hsa:56606
initial amount: NaN
boundary condition: true
type: Species
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110063#_ca598fe0_8556_4c0e_af5c_98f7db9b7449
constant: false
boundary condition: true
name: _AI924226_1_m
has only substance units: false
type: Species
initial concentration: NaN
initial amount: NaN
is: SBO:0000252
is encoded by: hsa:AI924226

metaM cmpacna g
has only substance units: false
initial amount: NaN
constant: false
is: CHEBI:57812
name: CMP-N-acetyl-beta-neuraminate(2-)
boundary condition: false
type: Species
notes: FORMULA: C20H29N4O16P CHARGE: -2 INCHI: InChI=1S/C20H31N4O16P/c1-7(26)22-12-8(27)4-20(18(32)33,39-16(12)13(29)9(28)5-25)40-41(35,36)37-6-10-14(30)15(31)17(38-10)24-3-2-11(21)23-19(24)34/h2-3,8-10,12-17,25,27-31H,4-6H2,1H3,(H,22,26)(H,32,33)(H,35,36)(H2,21,23,34)/p-2/t8-,9+,10+,12+,13+,14+,15+,16+,17+,20+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00126 EHMN_ABBREVIATION: C00128
is: HMDB01176
is: SBO:0000247
initial concentration: 1.0

metaM hs deg18 l
has only substance units: false
notes: FORMULA: C43H66N2O45S3 CHARGE: -4
is: HMDB01352
name: heparan sulfate, degradation product 18
initial concentration: 1.0
initial amount: NaN
constant: false
is: CHEBI:17180
type: Species
boundary condition: false
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110063#_d07ab15c_8a02_472f_b744_6e9d2d36a2c5
is: SBO:0000252
name: SLC4A5
initial amount: NaN
type: Species
has only substance units: false
is encoded by: hsa:57835
boundary condition: true
initial concentration: NaN
constant: false

http://identifiers.org/biomodels.db/MODEL1310110063#_3d5fbbfc_41e5_4694_b401_abc6a163ba63
is: SBO:0000252
constant: false
name: BCKDHB
initial concentration: NaN
boundary condition: true
initial amount: NaN
type: Species
has only substance units: false
is encoded by: hsa:594
is: Q9BQL0

metaR SPMS
kinetic law: MODEL1310110063#
notes: GENE_ASSOCIATION: (6723.1) SUBSYSTEM: Urea cycle EC Number: 2.5.1.16 Confidence Level: 4 AUTHORS: PMID:2069720,PMID:8343131 NOTES:
name: spermidine synthase
reversible: false
modifier: MODEL1310110063#
is version of: http://identifiers.org/ec-code/2.5.1.16
reactant: MODEL1310110063#
fast: false
product: MODEL1310110063#
type: Reaction
is described by: ECO:0000269
is: SBO:0000176

metaM HC01434 m
constant: false
notes: FORMULA: C6H3O7 CHARGE: -3 INCHI: InChI=1S/C6H6O7/c7-3(8)1-2(5(10)11)4(9)6(12)13/h2H,1H2,(H,7,8)(H,10,11)(H,12,13)/p-3 EHMN_ABBREVIATION: C05379
name: oxalatosuccinate(3-)
is: SBO:0000247
is: CHEBI:58931
boundary condition: false
type: Species
has only substance units: false
initial amount: NaN
initial concentration: 1.0

metaM acgal l
has only substance units: false
is: SBO:0000247
is: HMDB00212
is: CHEBI:28037
notes: FORMULA: C8H15NO6 CHARGE: 0 INCHI: InChI=1S/C8H15NO6/c1-3(11)9-5-7(13)6(12)4(2-10)15-8(5)14/h4-8,10,12-14H,2H2,1H3,(H,9,11)/t4-,5-,6+,7-,8?/m1/s1 EHMN_ABBREVIATION: C01132
initial amount: NaN
name: N-acetyl-D-galactosamine
boundary condition: false
constant: false
initial concentration: 1.0
type: Species

http://identifiers.org/biomodels.db/MODEL1310110063#_c83a01fb_6671_4dfc_b8a1_1e48f6dd54fd
name: SLC25A20
initial amount: NaN
is: SBO:0000252
constant: false
is: O43772
is encoded by: hsa:788
has only substance units: false
boundary condition: true
type: Species
initial concentration: NaN

metaR ACP1 FMN
is described by: ECO:0000254
reversible: false
fast: false
notes: GENE_ASSOCIATION: (52.1) or (52.3) or (52.2) SUBSYSTEM: Vitamin B2 metabolism EC Number: 3.1.3.2 Confidence Level: 2 AUTHORS: PMID:8522318 NOTES:INVALID ECO TERM: IFH
name: acid phosphatase (FMN)
reactant: MODEL1310110063#
product: MODEL1310110063#
kinetic law: MODEL1310110063#
is: SBO:0000176
modifier: MODEL1310110063#
is version of: http://identifiers.org/ec-code/3.1.3.2
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110063#_5c2951b8_5fcb_4f20_8416_2d99d0915954
initial amount: NaN
is: Q02153
constant: false
name: GUCY1B3
is: SBO:0000252
boundary condition: true
has only substance units: false
initial concentration: NaN
type: Species
is encoded by: hsa:2983

metaR EX gln L LPAREN e RPAREN
kinetic law: MODEL1310110063#
reactant: MODEL1310110063#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for L-glutamine
type: Reaction

metaR r1656
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
modifier: MODEL1310110063#
reactant: MODEL1310110063#
type: Reaction
fast: false
is described by: ECO:0000000
is: SBO:0000185
kinetic law: MODEL1310110063#
product: MODEL1310110063#
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110063#_43a3502d_f879_4977_8643_4c5c843f4b93
initial amount: NaN
initial concentration: NaN
has only substance units: false
is: SBO:0000252
type: Species
is: P11169
is encoded by: hsa:6515
name: SLC2A3
constant: false
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110063#_21bdb47d_6f06_4016_96bb_9e654b3c7cd2
constant: false
is: SBO:0000252
initial amount: NaN
type: Species
initial concentration: NaN
is encoded by: hsa:T83654
boundary condition: true
has only substance units: false
name: _T83654_1_m

http://identifiers.org/biomodels.db/MODEL1310110063#_48c09d8e_e454_43b0_822a_2affdba45a9e
name: ACP1
initial concentration: NaN
boundary condition: true
is encoded by: hsa:52
initial amount: NaN
is: SBO:0000252
has only substance units: false
type: Species
is: Q59EH3
constant: false

metaR RE2972M
is version of: http://identifiers.org/ec-code/2.7.1.67
modifier: MODEL1310110063#
is: SBO:0000176
fast: false
is described by: ECO:0000000
kinetic law: MODEL1310110063#
reactant: MODEL1310110063#
product: MODEL1310110063#
notes: GENE_ASSOCIATION: (5297.1) or (5298.1) SUBSYSTEM: Phosphatidylinositol phosphate metabolism EC Number: 2.7.1.67 Confidence Level: 0 AUTHORS: PMID:10358929,PMID:11493657,PMID:7961848,PMID:9211928 NOTES:
reversible: true
name: RE2972
type: Reaction

metaR r0596
type: Reaction
notes: GENE_ASSOCIATION: (6576.1) SUBSYSTEM: CoA synthesis EC Number: 3.1.2.4 Confidence Level: 0 AUTHORS: PMID:10989434,PMID:8188708,PMID:8824301 NOTES:
name: 3-hydroxyisobutyryl-CoA hydrolase beta-Alanine metabolism / Propanoate metabolism EC:3.1.2.4
reactant: MODEL1310110063#
product: MODEL1310110063#
fast: false
reversible: false
kinetic law: MODEL1310110063#
modifier: MODEL1310110063#
is described by: ECO:0000000
is: SBO:0000176

metaR 5MTAte
fast: false
reactant: MODEL1310110063#
reversible: true
kinetic law: MODEL1310110063#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
name: Transport of 5-S-methyl-5-thioadenosine
is described by: ECO:0000134
product: MODEL1310110063#
type: Reaction

metaR S4TASE5ly
kinetic law: MODEL1310110063#
product: MODEL1310110063#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.1.6.12
name: N-acetylgalactosamine-4-sulfatase, lysosomal
reversible: true
type: Reaction
is described by: ECO:0000000
fast: false
modifier: MODEL1310110063#
reactant: MODEL1310110063#
notes: GENE_ASSOCIATION: (411.1) or (411.2) SUBSYSTEM: Chondroitin sulfate degradation EC Number: 3.1.6.12 Confidence Level: 4 AUTHORS: PMID:1968043,PMID:2303452 NOTES:NCD

metaR r0839
notes: GENE_ASSOCIATION: (7108.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:7419607 NOTES:
modifier: MODEL1310110063#
type: Reaction
product: MODEL1310110063#
kinetic law: MODEL1310110063#
is: SBO:0000185
is version of: http://identifiers.org/ec-code/1.3.1.70
reversible: true
name: Postulated transport reaction
fast: false
reactant: MODEL1310110063#
is described by: ECO:0000000

metaM od2coa c
type: Species
notes: FORMULA: C39H64N7O17P3S CHARGE: -4 EHMN_ABBREVIATION: CE2244
is: SBO:0000247
boundary condition: false
has only substance units: false
constant: false
is: CHEBI:50570
initial amount: NaN
initial concentration: 1.0
is: HMDB06529
is: C16218
name: trans-Octadec-2-enoyl-CoA

metaM mescoa m
is: C06028
constant: false
is: SBO:0000247
initial concentration: 1.0
notes: FORMULA: C26H35N7O19P3S CHARGE: -5 INCHI: InChI=1S/C26H40N7O19P3S/c1-13(8-16(35)36)25(40)56-7-6-28-15(34)4-5-29-23(39)20(38)26(2,3)10-49-55(46,47)52-54(44,45)48-9-14-19(51-53(41,42)43)18(37)24(50-14)33-12-32-17-21(27)30-11-31-22(17)33/h8,11-12,14,18-20,24,37-38H,4-7,9-10H2,1-3H3,(H,28,34)(H,29,39)(H,35,36)(H,44,45)(H,46,47)(H2,27,30,31)(H2,41,42,43)/b13-8+/t14-,18-,19-,20+,24-/m1/s1
initial amount: NaN
type: Species
name: Mesaconyl-CoA
is: CHEBI:27969
has only substance units: false
boundary condition: false

metaM thcholoylcoa x
is: SBO:0000247
is: HMDB12456
constant: false
has only substance units: false
is: CHEBI:27403
initial amount: NaN
boundary condition: false
notes: FORMULA: C48H76N7O20P3S CHARGE: -4 INCHI: InChI=1S/C48H80N7O20P3S/c1-25(29-8-9-30-36-31(12-15-48(29,30)6)47(5)14-11-28(56)19-27(47)20-33(36)58)7-10-32(57)26(2)45(63)79-18-17-50-35(59)13-16-51-43(62)40(61)46(3,4)22-72-78(69,70)75-77(67,68)71-21-34-39(74-76(64,65)66)38(60)44(73-34)55-24-54-37-41(49)52-23-53-42(37)55/h23-34,36,38-40,44,56-58,60-61H,7-22H2,1-6H3,(H,50,59)(H,51,62)(H,67,68)(H,69,70)(H2,49,52,53)(H2,64,65,66)/t25-,26?,27+,28-,29-,30+,31+,32?,33-,34-,36+,38-,39-,40+,44-,47+,48-/m1/s1
name: 3alpha,7alpha,24-Trihydroxy-5beta-cholestanoyl-CoA
type: Species
initial concentration: 1.0

metaR r1655
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
type: Reaction
is: SBO:0000185
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reactant: MODEL1310110063#
is described by: ECO:0000000
reversible: true
modifier: MODEL1310110063#
fast: false
kinetic law: MODEL1310110063#
product: MODEL1310110063#

metaM 12ppd R c
is: SBO:0000247
notes: FORMULA: C3H8O2 CHARGE: 0 INCHI: InChI=1S/C3H8O2/c1-3(5)2-4/h3-5H,2H2,1H3/t3-/m1/s1
has only substance units: false
initial concentration: 1.0
name: (R)-propane-1,2-diol
constant: false
is: HMDB01881
initial amount: NaN
is: CHEBI:28972
type: Species
boundary condition: false

metaM dece4coa x
constant: false
initial concentration: 1.0
has only substance units: false
boundary condition: false
is: HMDB02145
initial amount: NaN
name: 4-decenoylcoa
type: Species
is: SBO:0000247
notes: FORMULA: C31H48N7O17P3S CHARGE: -4

metaR PDE1
name: 3',5'-cyclic-nucleotide phosphodiesterase
reversible: false
modifier: MODEL1310110063#
type: Reaction
kinetic law: MODEL1310110063#
is: SBO:0000176
is described by: ECO:0000269
fast: false
is version of: http://identifiers.org/ec-code/3.1.4.17
reactant: MODEL1310110063#
product: MODEL1310110063#
is version of: http://identifiers.org/ec-code/3.1.4.35
notes: GENE_ASSOCIATION: (5139.1) or (5142.1) or (5151.3) or (5153.1) or (5150.2) or (5143.1) or (5150.1) or (5137.1) or (5144.1) or (5136.2) or (5140.2) or (5151.2) or (10846.1) or (5151.5) or (5140.1) or (5141.1) or (5138.1) or (5136.1) or (5151.4) or (5151.1) or (27115.1) or (50940.1) or (8622.1) SUBSYSTEM: Nucleotide interconversion EC Number: 3.1.4.17 Confidence Level: 4 AUTHORS: PMID:10725373,PMID:10872825,PMID:10906126,PMID:10952971,PMID:11050148,PMID:11114167,PMID:12038792,PMID:12135876,PMID:12154085,PMID:12388353,PMID:12681444,PMID:12764607,PMID:14604994,PMID:15147193,PMID:15272012,PMID:15480303,PMID:8884271,PMID:9210593,PMID:9419816 NOTES:NCD

metaM CE1939 e
notes: FORMULA: C7H18N2O CHARGE: 2 INCHI: InChI=1/C7H16N2O/c8-4-1-2-5-9-6-3-7-10/h7,9H,1-6,8H2/p+2 EHMN_ABBREVIATION: CE1939
is: CHEBI:36781
boundary condition: false
initial concentration: 1.0
is: SBO:0000247
type: Species
name: spermidine monoaldehyde 1
constant: false
has only substance units: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110063#_338bdab2_9284_4788_a58a_48513b06d6bf
initial amount: NaN
name: PIGF:PIGO
type: Species
is: SBO:0000297
boundary condition: true
has only substance units: false
is encoded by: hsa:84720
constant: false
is encoded by: hsa:5281
has part: Q6IB04
initial concentration: NaN

metaM HC01609 e
is: SBO:0000247
constant: false
is: CHEBI:28766
notes: FORMULA: C40H36N4O16 CHARGE: -8 INCHI: InChI=1S/C40H44N4O16/c45-33(46)5-1-17-21(9-37(53)54)29-14-26-19(3-7-35(49)50)23(11-39(57)58)31(43-26)16-28-20(4-8-36(51)52)24(12-40(59)60)32(44-28)15-27-18(2-6-34(47)48)22(10-38(55)56)30(42-27)13-25(17)41-29/h41-44H,1-16H2,(H,45,46)(H,47,48)(H,49,50)(H,51,52)(H,53,54)(H,55,56)(H,57,58)(H,59,60) EHMN_ABBREVIATION: C05766
initial concentration: 1.0
type: Species
name: UroporphyrinogenI
has only substance units: false
initial amount: NaN
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110063#_b1b43766_08ab_4a61_a136_e1bfa84795a5
type: Species
has only substance units: false
constant: false
is: SBO:0000252
initial amount: NaN
name: PGM3
is: B4DX94
initial concentration: NaN
is encoded by: hsa:5238
boundary condition: true

metaR r0995
reactant: MODEL1310110063#
is described by: ECO:0000000
name: Mitochondrial Carrier (MC) TCDB:2.A.29.8.3
fast: false
reversible: true
type: Reaction
product: MODEL1310110063#
is: SBO:0000185
kinetic law: MODEL1310110063#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:1735445,PMID:18406340,PMID:1988962,PMID:2351134,PMID:2355017,PMID:6361812,PMID:7892212,PMID:8132483 NOTES:

metaR TETPENT6COAtx
kinetic law: MODEL1310110063#
is: SBO:0000185
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 0 AUTHORS: NOTES:interaction between peroxisomes and ER (some enzymes on the outer membrane) NJ
reversible: true
name: fatty acid intracellular transport
type: Reaction
product: MODEL1310110063#
fast: false
reactant: MODEL1310110063#

http://identifiers.org/biomodels.db/MODEL1310110063#_1785ef09_a3d4_4161_9388_8377f9000fc1
boundary condition: true
is: SBO:0000252
has only substance units: false
is encoded by: hsa:5152
name: PDE9A
initial amount: NaN
constant: false
initial concentration: NaN
type: Species

metaR SUCCACT
kinetic law: MODEL1310110063#
product: MODEL1310110063#
reactant: MODEL1310110063#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: activation of succinate
type: Reaction

metaR r2142
is described by: ECO:0000000
fast: false
product: MODEL1310110063#
reactant: MODEL1310110063#
type: Reaction
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.14
kinetic law: MODEL1310110063#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
modifier: MODEL1310110063#
reversible: true
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110063#_7cc1182e_6949_402d_b32f_6a9fdcad719c
name: _NOS2A_1_c
is encoded by: hsa:NOS2A
has only substance units: false
boundary condition: true
type: Species
initial concentration: NaN
constant: false
initial amount: NaN
is: SBO:0000252

metaM dcyt n
has only substance units: false
initial amount: NaN
is: CHEBI:15698
name: 2'-deoxycytidine
is: HMDB00014
is: SBO:0000247
boundary condition: false
type: Species
initial concentration: 1.0
constant: false
notes: FORMULA: C9H13N3O4 CHARGE: 0 INCHI: InChI=1S/C9H13N3O4/c10-7-1-2-12(9(15)11-7)8-3-5(14)6(4-13)16-8/h1-2,5-6,8,13-14H,3-4H2,(H2,10,11,15)/t5-,6+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00574 EHMN_ABBREVIATION: C00881

metaM cmpacna c
initial amount: NaN
notes: FORMULA: C20H29N4O16P CHARGE: -2 INCHI: InChI=1S/C20H31N4O16P/c1-7(26)22-12-8(27)4-20(18(32)33,39-16(12)13(29)9(28)5-25)40-41(35,36)37-6-10-14(30)15(31)17(38-10)24-3-2-11(21)23-19(24)34/h2-3,8-10,12-17,25,27-31H,4-6H2,1H3,(H,22,26)(H,32,33)(H,35,36)(H2,21,23,34)/p-2/t8-,9+,10+,12+,13+,14+,15+,16+,17+,20+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00126 EHMN_ABBREVIATION: C00128
is: SBO:0000247
is: CHEBI:57812
boundary condition: false
is: HMDB01176
has only substance units: false
constant: false
initial concentration: 1.0
name: CMP-N-acetyl-beta-neuraminate(2-)
type: Species

metaR FATP6t
kinetic law: MODEL1310110063#
product: MODEL1310110063#
is: SBO:0000185
fast: false
is version of: http://identifiers.org/ec-code/6.2.1.3
is version of: http://identifiers.org/ec-code/6.2.1.7
type: Reaction
modifier: MODEL1310110063#
notes: GENE_ASSOCIATION: (10998.1) or (11001.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10479480,PMID:12856180,PMID:15522816 NOTES:electroneutral transport NJ
reversible: true
is described by: ECO:0000269
reactant: MODEL1310110063#
name: fatty acid electroneutral transport

metaR r1657
type: Reaction
modifier: MODEL1310110063#
kinetic law: MODEL1310110063#
is: SBO:0000185
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reactant: MODEL1310110063#
is described by: ECO:0000000
reversible: true
product: MODEL1310110063#
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
fast: false

http://identifiers.org/biomodels.db/MODEL1310110063#_e7010427_a30f_47d5_8a75_0d53edc7081e
has only substance units: false
is encoded by: hsa:501
boundary condition: true
initial concentration: NaN
is: E7EPT3
name: ALDH7A1
constant: false
type: Species
is: SBO:0000252
initial amount: NaN

metaM ksi deg34 l
notes: FORMULA: C76H126N5O59S1 CHARGE: -1
initial concentration: 1.0
boundary condition: false
is: CHEBI:57455
initial amount: NaN
has only substance units: false
is: SBO:0000247
name: keratan sulfate I, degradation product 34
is: HMDB01354
type: Species
constant: false

metaM hexccoa c
notes: FORMULA: C47H82N7O17P3S CHARGE: -4 INCHI: InChI=1/C47H86N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-24-25-26-27-38(56)75-31-30-49-37(55)28-29-50-45(59)42(58)47(2,3)33-68-74(65,66)71-73(63,64)67-32-36-41(70-72(60,61)62)40(57)46(69-36)54-35-53-39-43(48)51-34-52-44(39)54/h34-36,40-42,46,57-58H,4-33H2,1-3H3,(H,49,55)(H,50,59)(H,63,64)(H,65,66)(H2,48,51,52)(H2,60,61,62)/p-4/t36-,40-,41-,42+,46-/m1/s1
is: SBO:0000247
name: Hexacosanoyl-CoA (n-C26:0CoA)
has only substance units: false
initial amount: NaN
constant: false
is: HMDB06459
initial concentration: 1.0
boundary condition: false
type: Species

metaR r0994
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:15975683 NOTES:
product: MODEL1310110063#
is: SBO:0000185
kinetic law: MODEL1310110063#
is described by: ECO:0000000
reversible: true
name: Facilitated diffusion
type: Reaction
reactant: MODEL1310110063#
fast: false

metaM m2mn l
boundary condition: false
constant: false
name: (alpha-D-mannosyl)2-beta-D-mannosyl-N-acetylglucosamine
is: HMDB06537
has only substance units: false
initial concentration: 1.0
notes: FORMULA: C26H45NO21 CHARGE: 0 INCHI: InChI=1/C26H45NO21/c1-6(32)27-11-15(36)20(10(5-31)42-23(11)41)46-25-18(39)22(14(35)8(3-29)44-25)48-26-19(40)21(13(34)9(4-30)45-26)47-24-17(38)16(37)12(33)7(2-28)43-24/h7-26,28-31,33-41H,2-5H2,1H3,(H,27,32)/t7-,8-,9-,10+,11+,12-,13-,14-,15+,16+,17+,18+,19+,20+,21+,22+,23+,24-,25+,26+/m0/s1
type: Species
initial amount: NaN
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110063#_b3c4008f_7e43_4f3c_a333_135c29217aee
initial concentration: NaN
is encoded by: hsa:4715
constant: false
is: SBO:0000252
type: Species
is: Q9Y6M9
name: NDUFB9
boundary condition: true
has only substance units: false
initial amount: NaN

metaM akg m
name: 2-Oxoglutarate
is: CHEBI:16810
is: C00026
is: HMDB00208
is: SBO:0000247
initial concentration: 1.0
initial amount: NaN
constant: false
notes: FORMULA: C5H4O5 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00035 EHMN_ABBREVIATION: C00026
has only substance units: false
type: Species
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110063#_572f7296_f524_42b1_a8ab_4427f578ede5
type: Species
initial concentration: NaN
constant: false
has only substance units: false
name: ALDH18A1
is: SBO:0000252
initial amount: NaN
is: P54886
is encoded by: hsa:5832
boundary condition: true

metaR r1658
fast: false
modifier: MODEL1310110063#
reactant: MODEL1310110063#
kinetic law: MODEL1310110063#
product: MODEL1310110063#
type: Reaction
reversible: true
is described by: ECO:0000000
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110063#_dd074b6f_eb59_4368_80a5_d292aad1f0b4
is: P21953
initial amount: NaN
initial concentration: NaN
is: SBO:0000252
boundary condition: true
type: Species
is encoded by: hsa:594
has only substance units: false
name: BCKDHB
constant: false

metaM thbpt c
has only substance units: false
initial concentration: 1.0
constant: false
boundary condition: false
notes: FORMULA: C9H15N5O3 CHARGE: 0 INCHI: InChI=1S/C9H15N5O3/c1-3(15)6(16)4-2-11-7-5(12-4)8(17)14-9(10)13-7/h3-4,6,12,15-16H,2H2,1H3,(H4,10,11,13,14,17) HEPATONET_1.0_ABBREVIATION: HC00245 EHMN_ABBREVIATION: C00272
name: 5,6,7,8-tetrahydrobiopterin
is: SBO:0000247
is: CHEBI:15372
is: HMDB00027
type: Species
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110063#_c13fe7ff_1ef4_40cf_be0f_03657a140797
name: PIK3C2G
initial amount: NaN
is: O75747
is: SBO:0000252
is encoded by: hsa:5288
constant: false
has only substance units: false
boundary condition: true
type: Species
initial concentration: NaN

metaM galgbside hs g
boundary condition: false
initial concentration: 1.0
is: SBO:0000247
constant: false
notes: FORMULA: C50H89N2O27FULLRCO CHARGE: 0
initial amount: NaN
name: galactosylgloboside
has only substance units: false
is: CHEBI:18259
type: Species

http://identifiers.org/biomodels.db/MODEL1310110063#_d055a47d_7c69_4606_acb0_95118c6bcd0b
constant: false
is: SBO:0000252
is encoded by: hsa:3612
boundary condition: true
has only substance units: false
initial amount: NaN
initial concentration: NaN
type: Species
is: B7Z6Q4
name: IMPA1

http://identifiers.org/biomodels.db/MODEL1310110063#_902676f5_289b_4e5b_b6cd_61710ed85a84
initial concentration: NaN
boundary condition: true
type: Species
is: SBO:0000252
constant: false
name: PDE9A
has only substance units: false
initial amount: NaN
is encoded by: hsa:5152

metaM ksi deg12 l
boundary condition: false
is: SBO:0000247
has only substance units: false
initial amount: NaN
type: Species
initial concentration: 1.0
name: keratan sulfate I, degradation product 12
is: HMDB00143
constant: false
notes: FORMULA: C174H279N12O153S9 CHARGE: -9
is: CHEBI:12936

http://identifiers.org/biomodels.db/MODEL1310110063#_29a30601_74c1_47e3_b70b_f3052dfeb668
initial amount: NaN
name: SLC25A22
constant: false
is encoded by: hsa:79751
boundary condition: true
is: SBO:0000252
type: Species
has only substance units: false
initial concentration: NaN
is: Q9H936

http://identifiers.org/biomodels.db/MODEL1310110063#_37d198df_4e3e_4a16_a9d6_c406b92fd1e7
is encoded by: hsa:1738
boundary condition: true
is: P09622
type: Species
has only substance units: false
initial concentration: NaN
is: SBO:0000252
initial amount: NaN
name: DLD
constant: false

metaR S6T9g
name: galactose/N-acetylglucosamine 6-O-sulfotransferase, Golgi apparatus
type: Reaction
modifier: MODEL1310110063#
is: SBO:0000176
notes: GENE_ASSOCIATION: (23563.2) or (9435.1) or (23563.1) or (10164.1) or (4166.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: Confidence Level: 4 AUTHORS: PMID:10330415,PMID:10491328,PMID:10913333,PMID:11278593,PMID:12403612,PMID:12855678,PMID:9722682 NOTES:NCD
fast: false
is described by: ECO:0000000
kinetic law: MODEL1310110063#
product: MODEL1310110063#
reversible: false
reactant: MODEL1310110063#

metaR NAGLCAly
is: SBO:0000176
reversible: false
product: MODEL1310110063#
name: N-acetylglucosaminidase, lysosomal
fast: false
reactant: MODEL1310110063#
type: Reaction
kinetic law: MODEL1310110063#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Keratan sulfate degradation EC Number: Confidence Level: 1 AUTHORS: NOTES:EC 3.2.1.- This reaction is my best guess at how the GlcNAc-beta-1,6-GalNAc linkage is cleaved. NCD

metaR UMPK
kinetic law: MODEL1310110063#
is described by: ECO:0000269
name: UMP kinase
product: MODEL1310110063#
is: SBO:0000176
type: Reaction
fast: false
modifier: MODEL1310110063#
reactant: MODEL1310110063#
is version of: http://identifiers.org/ec-code/2.7.4.14
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: NOTES:
reversible: true

metaR r2140
is: SBO:0000185
is described by: ECO:0000000
reversible: true
kinetic law: MODEL1310110063#
reactant: MODEL1310110063#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
type: Reaction
product: MODEL1310110063#
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.14
fast: false
modifier: MODEL1310110063#

metaM but c
has only substance units: false
is: CHEBI:17968
constant: false
is: HMDB00039
is: SBO:0000247
notes: FORMULA: C4H7O2 CHARGE: -1 INCHI: InChI=1S/C4H8O2/c1-2-3-4(5)6/h2-3H2,1H3,(H,5,6)/p-1 HEPATONET_1.0_ABBREVIATION: HC00223 EHMN_ABBREVIATION: C00246
initial concentration: 1.0
type: Species
initial amount: NaN
boundary condition: false
name: butyrate

metaR RIBt2
reversible: false
kinetic law: MODEL1310110063#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:15234337 NOTES:NCD
is: SBO:0000185
is described by: ECO:0000000
product: MODEL1310110063#
name: ribose transport in via proton symporter
fast: false
reactant: MODEL1310110063#

http://identifiers.org/biomodels.db/MODEL1310110063#_bf4c3de4_6cd8_438a_a30e_5d6cc7963d81
is: P11310
initial amount: NaN
initial concentration: NaN
has only substance units: false
name: ACADM
constant: false
type: Species
boundary condition: true
is: SBO:0000252
is encoded by: hsa:34

metaR TYRCBOX
kinetic law: MODEL1310110063#
is version of: http://identifiers.org/ec-code/4.1.1.28
is described by: ECO:0000134
product: MODEL1310110063#
is: SBO:0000176
notes: GENE_ASSOCIATION: (1644.1) SUBSYSTEM: Tyrosine metabolism EC Number: 4.1.1.28 Confidence Level: 4 AUTHORS: PMID:6131938 NOTES:SAB KEGG also says EC 4.1.1.28
type: Reaction
name: L-Tyrosine carboxy-lyase
fast: false
modifier: MODEL1310110063#
reversible: false
reactant: MODEL1310110063#

http://identifiers.org/biomodels.db/MODEL1310110063#_2946d352_6786_47cc_9448_d9a94b0e921d
type: Species
boundary condition: true
name: _286297_1_c
initial amount: NaN
constant: false
is encoded by: hsa:286297
initial concentration: NaN
has only substance units: false
is: SBO:0000252

metaM ksii core2 deg6 l
initial amount: NaN
constant: false
is: SBO:0000247
notes: FORMULA: C44H72N4O33SX CHARGE: -1
boundary condition: false
name: keratan sulfate II (core 2-linked), degradation product 6
has only substance units: false
type: Species
is: HMDB00143
is: CHEBI:12936
initial concentration: 1.0

metaR r1659
type: Reaction
is: SBO:0000185
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reversible: true
reactant: MODEL1310110063#
fast: false
product: MODEL1310110063#
is described by: ECO:0000000
kinetic law: MODEL1310110063#
modifier: MODEL1310110063#

http://identifiers.org/biomodels.db/MODEL1310110063#_1b045838_7a25_4b37_9860_94ad5a056eee
constant: false
initial amount: NaN
is: SBO:0000252
is: Q6IB80
has only substance units: false
is encoded by: hsa:4709
name: NDUFB3
type: Species
boundary condition: true
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110063#_0ba0b072_eda8_4ee3_b36b_80bf3eb8d1e8
has only substance units: false
is: P52789
is: SBO:0000252
constant: false
initial concentration: NaN
type: Species
is encoded by: hsa:3099
initial amount: NaN
name: HK2
boundary condition: true

metaM pectintchol e
is: SBO:0000247
initial concentration: 1.0
constant: false
name: pectin-taurocholic acid complex
notes: FORMULA: C2561H3555NO2542S CHARGE: 0
boundary condition: false
is: HMDB03402
type: Species
initial amount: NaN
has only substance units: false

metaM pe hs c
initial concentration: 1.0
type: Species
boundary condition: false
is: CHEBI:16038
initial amount: NaN
name: phosphatidylethanolamine
is: SBO:0000247
notes: FORMULA: C5H12NO4PFULLRCO2FULLR2CO2 CHARGE: 0
has only substance units: false
constant: false

http://identifiers.org/biomodels.db/MODEL1310110063#_70736817_287a_4c92_8c1b_1a5bc599e99e
boundary condition: true
initial concentration: NaN
type: Species
is encoded by: hsa:51292
constant: false
is: SBO:0000252
is: Q86T14
has only substance units: false
name: GMPR2
initial amount: NaN

metaR EX co LPAREN e RPAREN
kinetic law: MODEL1310110063#
reactant: MODEL1310110063#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Carbon monoxide exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110063#_c344a132_c5bf_49b1_94eb_62892280e8f4
has only substance units: false
is encoded by: hsa:AL050025
is: SBO:0000252
initial amount: NaN
initial concentration: NaN
name: _AL050025_1_c
type: Species
boundary condition: true
constant: false

http://identifiers.org/biomodels.db/MODEL1310110063#_7837eea9_600e_4988_966a_4a1eecf96ca5
name: PEMT
initial amount: NaN
is encoded by: hsa:10400
type: Species
constant: false
initial concentration: NaN
is: SBO:0000252
has only substance units: false
boundary condition: true

metaR r2141
reversible: true
product: MODEL1310110063#
reactant: MODEL1310110063#
kinetic law: MODEL1310110063#
is described by: ECO:0000000
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.14
type: Reaction
is: SBO:0000185
modifier: MODEL1310110063#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
fast: false

http://identifiers.org/biomodels.db/MODEL1310110063#_3f4e2e3d_afd6_4cc1_9918_3efb64358d91
initial concentration: NaN
is encoded by: hsa:9374
constant: false
boundary condition: true
initial amount: NaN
has only substance units: false
type: Species
is: Q9UMR5
name: PPT2
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110063#_f9642885_65a4_4b97_b94b_a72983e64b5b
constant: false
boundary condition: true
initial amount: NaN
initial concentration: NaN
type: Species
has only substance units: false
name: RHAG
is: Q96E98
is: SBO:0000252
is encoded by: hsa:6005

metaM udpglcur c
name: UDP-D-glucuronate
constant: false
is: HMDB00935
notes: FORMULA: C15H19N2O18P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00162 EHMN_ABBREVIATION: C00167
is: CHEBI:58052
is: SBO:0000247
boundary condition: false
has only substance units: false
is: C00167
initial amount: NaN
initial concentration: 1.0
type: Species

metaM but e
notes: FORMULA: C4H7O2 CHARGE: -1 INCHI: InChI=1S/C4H8O2/c1-2-3-4(5)6/h2-3H2,1H3,(H,5,6)/p-1 HEPATONET_1.0_ABBREVIATION: HC00223 EHMN_ABBREVIATION: C00246
constant: false
has only substance units: false
is: HMDB00039
is: SBO:0000247
boundary condition: false
is: CHEBI:17968
type: Species
initial concentration: 1.0
name: butyrate
initial amount: NaN

metaR FAOXC163Gm
kinetic law: MODEL1310110063#
product: MODEL1310110063#
reactant: MODEL1310110063#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: isomerization(C16:3)gm
type: Reaction

metaM HC02213 c
has only substance units: false
notes: FORMULA: C20H29O5 CHARGE: -1 INCHI: InChI=1S/C20H30O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h3-4,6-7,12-13,15-17,19,21,23H,2,5,8-11,14H2,1H3,(H,24,25)/b6-3-,7-4-,13-12+/t15-,16+,17+,19+/m0/s1 EHMN_ABBREVIATION: C06439
is: SBO:0000247
initial concentration: 1.0
constant: false
boundary condition: false
name: prostaglandin-e3
initial amount: NaN
type: Species
is: CHEBI:28031

metaR HCO3 CLt
kinetic law: MODEL1310110063#
reactant: MODEL1310110063#
product: MODEL1310110063#
modifier: MODEL1310110063#
reversible: true
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (6522.1) or (83697.1) or (6521.1) or (6508.2) or (6508.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:11302728,PMID:12027221,PMID:14722772 NOTES:MM
type: Reaction
is: SBO:0000185
fast: false
name: bicarbonate transport (Cl-/HCO3- exchange)

http://identifiers.org/biomodels.db/MODEL1310110063#_7638c8dd_c843_4f44_baed_fc660af382b7
type: Species
initial concentration: NaN
is: SBO:0000252
initial amount: NaN
boundary condition: true
has only substance units: false
name: CHST2
is: Q9Y4C5
constant: false
is encoded by: hsa:9435

http://identifiers.org/biomodels.db/MODEL1310110063#_d9143168_df4e_40ca_9d91_a7c0c4a68f38
boundary condition: true
initial amount: NaN
initial concentration: NaN
has only substance units: false
name: NDUFB6
is: O95139
is encoded by: hsa:4712
is: SBO:0000252
constant: false
type: Species

metaR r0999
reactant: MODEL1310110063#
is: SBO:0000185
is described by: ECO:0000000
type: Reaction
name: Facilitated diffusion
product: MODEL1310110063#
fast: false
kinetic law: MODEL1310110063#
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:1735445,PMID:18406340,PMID:1988962,PMID:2351134,PMID:2355017,PMID:6361812,PMID:7892212,PMID:8132483 NOTES:

metaM dece4coa m
name: 4-decenoylcoa
is: HMDB02145
constant: false
notes: FORMULA: C31H48N7O17P3S CHARGE: -4
initial amount: NaN
is: SBO:0000247
boundary condition: false
type: Species
initial concentration: 1.0
has only substance units: false

metaR CLPNDCOAtx
kinetic law: MODEL1310110063#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: NOTES:interaction between peroxisomes and ER (some enzymes on the outer membrane) NJ
type: Reaction
is described by: ECO:0000000
product: MODEL1310110063#
fast: false
reversible: true
reactant: MODEL1310110063#
name: fatty acid intracellular transport

http://identifiers.org/biomodels.db/MODEL1310110063#_e7701e77_61a9_4b10_836b_604fa659a3bb
initial concentration: NaN
constant: false
initial amount: NaN
name: ATP5J
is encoded by: hsa:522
boundary condition: true
has only substance units: false
type: Species
is: SBO:0000252

metaR DNDPt14m
kinetic law: MODEL1310110063#
type: Reaction
is: SBO:0000185
reversible: false
reactant: MODEL1310110063#
name: dUDP transport via dTDP antiport
fast: false
is described by: ECO:0000269
modifier: MODEL1310110063#
product: MODEL1310110063#
notes: GENE_ASSOCIATION: (60386.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:11226231 NOTES:IT

metaM zym int2 r
is: SBO:0000247
is: CHEBI:52386
type: Species
name: zymosterol intermediate 2
initial concentration: 1.0
boundary condition: false
notes: FORMULA: C27H42O CHARGE: 0 INCHI: InChI=1S/C27H42O/c1-18(2)7-6-8-19(3)23-11-12-24-22-10-9-20-17-21(28)13-15-26(20,4)25(22)14-16-27(23,24)5/h7,19-20,23-24H,6,8-17H2,1-5H3/t19-,20+,23-,24+,26+,27-/m1/s1
constant: false
initial amount: NaN
has only substance units: false

metaM lnlncacrn m
constant: false
boundary condition: false
type: Species
has only substance units: false
initial amount: NaN
is: HMDB06319
notes: FORMULA: C25H43NO4 CHARGE: 0 INCHI: InChI=1/C25H43NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-25(29)30-23(26(2,3)4)21-22-24(27)28/h6-7,9-10,12-13,23H,5,8,11,14-22H2,1-4H3/b7-6-,10-9-,13-12-/t23-/m0/s1
is: SBO:0000247
name: alpha-linolenyl carnitine
initial concentration: 1.0

metaM thmmp c
name: Thiamin monophosphate
initial concentration: 1.0
is: CHEBI:37575
is: HMDB02666
is: SBO:0000247
notes: FORMULA: C12H16N4O4PS CHARGE: -1 EHMN_ABBREVIATION: C01081
is: C01081
has only substance units: false
initial amount: NaN
constant: false
boundary condition: false
type: Species

metaR BTNDe
reactant: MODEL1310110063#
is: SBO:0000176
reversible: false
is version of: http://identifiers.org/ec-code/3.5.1.12
type: Reaction
kinetic law: MODEL1310110063#
notes: GENE_ASSOCIATION: (686.1) SUBSYSTEM: Biotin metabolism EC Number: 3.5.1.12 Confidence Level: 4 AUTHORS: PMID:12459313,PMID:7509806,PMID:8001986 NOTES:Also acts on biotin esters IT
is described by: ECO:0000269
fast: false
name: biotinidase (biotin), extracellular
modifier: MODEL1310110063#
product: MODEL1310110063#

metaR HEXCOAACBP
kinetic law: MODEL1310110063#
product: MODEL1310110063#
reactant: MODEL1310110063#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of Hexanoyl-CoA (n-C6:0CoA) from mitochondria into cytosol
type: Reaction

metaM i c
constant: false
is: CHEBI:16382
is: HMDB12238
notes: FORMULA: I CHARGE: -1 INCHI: InChI=1S/HI/h1H/p-1 EHMN_ABBREVIATION: C00708
is: SBO:0000247
has only substance units: false
name: iodide
initial concentration: 1.0
initial amount: NaN
type: Species
boundary condition: false

metaR FAOXC102C81x
kinetic law: MODEL1310110063#
product: MODEL1310110063#
reactant: MODEL1310110063#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C10:2-->C8:1)x
type: Reaction

metaR r0998
name: Facilitated diffusion
product: MODEL1310110063#
reversible: true
is described by: ECO:0000000
fast: false
kinetic law: MODEL1310110063#
type: Reaction
reactant: MODEL1310110063#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:1735445,PMID:18406340,PMID:1988962,PMID:2351134,PMID:2355017,PMID:6361812,PMID:7892212,PMID:8132483 NOTES:
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110063#_09cfb414_7879_4e74_bd30_39038db35bf2
is encoded by: hsa:1836
boundary condition: true
has only substance units: false
initial amount: NaN
name: SLC26A2
initial concentration: NaN
type: Species
constant: false
is: SBO:0000252
is: P50443

metaM xol7ah2al m
boundary condition: false
has only substance units: false
is: SBO:0000247
initial concentration: 1.0
is: CHEBI:27428
is: HMDB06894
notes: FORMULA: C27H46O3 CHARGE: 0 INCHI: InChI=1S/C27H46O3/c1-17(16-28)6-5-7-18(2)21-8-9-22-25-23(11-13-27(21,22)4)26(3)12-10-20(29)14-19(26)15-24(25)30/h16-25,29-30H,5-15H2,1-4H3/t17?,18-,19+,20-,21-,22+,23+,24-,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01454 EHMN_ABBREVIATION: C05445
type: Species
initial amount: NaN
constant: false
name: 3alpha,7alpha-dihydroxy-5beta-cholestan-26-al

metaR IDPtn
type: Reaction
kinetic law: MODEL1310110063#
name: IDP nuclear transport
product: MODEL1310110063#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: NOTES:IT
reactant: MODEL1310110063#
reversible: true
is described by: ECO:0000000
is: SBO:0000185

metaR NAt3 1
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (389015.1) or (6548.1) or (6550.1) or (6549.1) or (6553.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10444453,PMID:12845533,PMID:2536298,PMID:2581505,PMID:7631746,PMID:7759094,PMID:8199403,PMID:8595899,PMID:9933641 NOTES:JLR
is: SBO:0000185
name: sodium proton antiporter (H:NA is 1:1)
fast: false
reversible: true
product: MODEL1310110063#
modifier: MODEL1310110063#
kinetic law: MODEL1310110063#
type: Reaction
reactant: MODEL1310110063#

http://identifiers.org/biomodels.db/MODEL1310110063#_3abe9ff2_86c4_417a_8c3c_cc96d18ace53
is: SBO:0000252
initial concentration: NaN
name: PPA1
type: Species
boundary condition: true
constant: false
has only substance units: false
is encoded by: hsa:5464
initial amount: NaN
is: Q15181

metaM Asn X Ser Thr r
is: SBO:0000247
is: CHEBI:28938
is: C01342
boundary condition: false
constant: false
has only substance units: false
notes: FORMULA: XH CHARGE: 0
initial amount: NaN
type: Species
initial concentration: 1.0
is: HMDB00051
name: protein-linked asparagine residue (N-glycosylation site)

metaM HC02213 e
has only substance units: false
notes: FORMULA: C20H29O5 CHARGE: -1 INCHI: InChI=1S/C20H30O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h3-4,6-7,12-13,15-17,19,21,23H,2,5,8-11,14H2,1H3,(H,24,25)/b6-3-,7-4-,13-12+/t15-,16+,17+,19+/m0/s1 EHMN_ABBREVIATION: C06439
is: SBO:0000247
constant: false
initial concentration: 1.0
type: Species
initial amount: NaN
name: prostaglandin-e3
boundary condition: false
is: CHEBI:28031

metaR ME2m
product: MODEL1310110063#
reactant: MODEL1310110063#
reversible: false
kinetic law: MODEL1310110063#
type: Reaction
fast: false
is: SBO:0000176
modifier: MODEL1310110063#
notes: GENE_ASSOCIATION: (4200.1) or (10873.1) SUBSYSTEM: Pyruvate metabolism EC Number: 1.1.1.40 Confidence Level: 0 AUTHORS: PMID:1993674 NOTES:IF
name: malic enzyme (NADP), mitochondrial
is version of: http://identifiers.org/ec-code/1.1.1.38
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/1.1.1.40

http://identifiers.org/biomodels.db/MODEL1310110063#_42ac127c_3f57_48b6_be90_3e1cf3980edf
name: PRDX1
initial amount: NaN
constant: false
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:5052
has only substance units: false
type: Species
boundary condition: true

metaR FAOXC16DCr
kinetic law: MODEL1310110063#
product: MODEL1310110063#
reactant: MODEL1310110063#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid activation(C16DC)er
type: Reaction

metaM CE4790 m
boundary condition: false
is: CHEBI:57923
name: (3S)-3-hydroxy-cis-8-tetradecenoyl-CoA
is: SBO:0000247
type: Species
initial concentration: 1.0
constant: false
has only substance units: false
notes: FORMULA: C35H56N7O18P3S CHARGE: -4 INCHI: InChI=1/C35H60N7O18P3S/c1-4-5-6-7-8-9-10-11-12-13-23(43)18-26(45)64-17-16-37-25(44)14-15-38-33(48)30(47)35(2,3)20-57-63(54,55)60-62(52,53)56-19-24-29(59-61(49,50)51)28(46)34(58-24)42-22-41-27-31(36)39-21-40-32(27)42/h8-9,21-24,28-30,34,43,46-47H,4-7,10-20H2,1-3H3,(H,37,44)(H,38,48)(H,52,53)(H,54,55)(H2,36,39,40)(H2,49,50,51)/p-4/b9-8-/t23-,24-,28+,29+,30u,34-/m0/s1 EHMN_ABBREVIATION: CE4790
initial amount: NaN

metaM dmnoncrn x
name: 4,8-dimethylnonanoyl carnitine
is: SBO:0000247
boundary condition: false
initial concentration: 1.0
is: HMDB06202
initial amount: NaN
has only substance units: false
notes: FORMULA: C18H37NO4 CHARGE: 0
constant: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110063#_10783d02_ace0_4888_8855_3a47ce2a4efa
type: Species
is: Q9H2F3
has only substance units: false
boundary condition: true
constant: false
initial amount: NaN
is: SBO:0000252
is encoded by: hsa:80270
name: HSD3B7
initial concentration: NaN

metaR EX c3dc
kinetic law: MODEL1310110063#
reactant: MODEL1310110063#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for malonyl carnitine
type: Reaction

metaR r0165
name: UTP:pyruvate O2-phosphotransferase EC:2.7.1.40
modifier: MODEL1310110063#
reversible: false
product: MODEL1310110063#
reactant: MODEL1310110063#
kinetic law: MODEL1310110063#
is: SBO:0000176
type: Reaction
notes: GENE_ASSOCIATION: (6576.1) SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: 2.7.1.40 Confidence Level: 0 AUTHORS: PMID:1009117,PMID:7154942 NOTES:
is described by: ECO:0000000
fast: false

metaR PRPNCOAHYDm
name: Propenoyl-CoA hydrolase (m)
product: MODEL1310110063#
is version of: http://identifiers.org/ec-code/2.3.1.16
is version of: http://identifiers.org/ec-code/4.2.1.18
is version of: http://identifiers.org/ec-code/4.2.1.17
is: SBO:0000176
is described by: ECO:0000134
reactant: MODEL1310110063#
reversible: false
fast: false
modifier: MODEL1310110063#
kinetic law: MODEL1310110063#
notes: GENE_ASSOCIATION: (1892.1) or (3030.1) and (3032.1) or (549.1) SUBSYSTEM: beta-Alanine metabolism EC Number: 4.2.1.17 Confidence Level: 1 AUTHORS: PMID:8824301 NOTES:SAB made up name because name in KEGG seemed wrong. in vitro assay
type: Reaction

metaM i e
has only substance units: false
type: Species
name: iodide
initial amount: NaN
boundary condition: false
constant: false
notes: FORMULA: I CHARGE: -1 INCHI: InChI=1S/HI/h1H/p-1 EHMN_ABBREVIATION: C00708
is: SBO:0000247
initial concentration: 1.0
is: CHEBI:16382
is: HMDB12238

metaR HS4ly
is version of: http://identifiers.org/ec-code/3.10.1.1
product: MODEL1310110063#
modifier: MODEL1310110063#
notes: GENE_ASSOCIATION: (6448.1) SUBSYSTEM: Heparan sulfate degradation EC Number: 3.10.1.1 Confidence Level: 4 AUTHORS: PMID:7493035,PMID:8993162,PMID:9405287 NOTES:NCD
reversible: false
name: heparan-N-sulfatase, lysosomal
reactant: MODEL1310110063#
is described by: ECO:0000000
type: Reaction
is: SBO:0000176
fast: false
kinetic law: MODEL1310110063#

metaM 3aib m
constant: false
is: HMDB02166
is: SBO:0000247
notes: FORMULA: C4H9NO2 CHARGE: 0 INCHI: InChI=1S/C4H9NO2/c1-3(2-5)4(6)7/h3H,2,5H2,1H3,(H,6,7)/t3-/m0/s1 EHMN_ABBREVIATION: C03284
is: CHEBI:33094
name: (S)-3-aminoisobutyric acid
boundary condition: false
initial amount: NaN
has only substance units: false
initial concentration: 1.0
type: Species

http://identifiers.org/biomodels.db/MODEL1310110063#_143f015a_bcba_4c9a_b3df_121d29a49a84
initial amount: NaN
has only substance units: false
is: B4DG68
initial concentration: NaN
type: Species
boundary condition: true
is encoded by: hsa:4842
is: SBO:0000252
constant: false
name: NOS1

http://identifiers.org/biomodels.db/MODEL1310110063#_721803d8_ee15_4f33_9a48_0fc76af00f42
initial concentration: NaN
boundary condition: true
constant: false
initial amount: NaN
is: P48735
type: Species
name: IDH2
has only substance units: false
is: SBO:0000252
is encoded by: hsa:3418

metaM utp c
initial amount: NaN
initial concentration: 1.0
boundary condition: false
is: C00075
constant: false
type: Species
is: HMDB00285
notes: FORMULA: C9H11N2O15P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00077 EHMN_ABBREVIATION: C00075
has only substance units: false
is: SBO:0000247
is: CHEBI:46398
name: UTP

metaM pristcoa c
is: SBO:0000247
has only substance units: false
name: pristanoyl coa
initial concentration: 1.0
is: CHEBI:51341
constant: false
notes: FORMULA: C40H68N7O17P3S CHARGE: -4 INCHI: InChI=1/C40H72N7O17P3S/c1-25(2)11-8-12-26(3)13-9-14-27(4)15-10-16-28(5)39(52)68-20-19-42-30(48)17-18-43-37(51)34(50)40(6,7)22-61-67(58,59)64-66(56,57)60-21-29-33(63-65(53,54)55)32(49)38(62-29)47-24-46-31-35(41)44-23-45-36(31)47/h23-29,32-34,38,49-50H,8-22H2,1-7H3,(H,42,48)(H,43,51)(H,56,57)(H,58,59)(H2,41,44,45)(H2,53,54,55)/t26?,27?,28?,29-,32-,33-,34+,38-/m1/s1/f/h42-43,53-54,56,58H,41H2
type: Species
boundary condition: false
initial amount: NaN

metaM HC01412 m
constant: false
is: SBO:0000247
has only substance units: false
is: CHEBI:61405
initial amount: NaN
type: Species
name: trans-tetradec-2-enoyl-CoA(4-)
initial concentration: 1.0
boundary condition: false
notes: FORMULA: C35H56N7O17P3S CHARGE: -4 INCHI: InChI=1S/C35H60N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-26(44)63-19-18-37-25(43)16-17-38-33(47)30(46)35(2,3)21-56-62(53,54)59-61(51,52)55-20-24-29(58-60(48,49)50)28(45)34(57-24)42-23-41-27-31(36)39-22-40-32(27)42/h14-15,22-24,28-30,34,45-46H,4-13,16-21H2,1-3H3,(H,37,43)(H,38,47)(H,51,52)(H,53,54)(H2,36,39,40)(H2,48,49,50)/p-4/b15-14+/t24-,28-,29-,30+,34-/m1/s1 EHMN_ABBREVIATION: C05273

metaM ksii core4 pre2 g
is: SBO:0000247
is: CHEBI:58053
has only substance units: false
initial amount: NaN
initial concentration: 1.0
constant: false
name: keratan sulfate II boisynthesis, precursor 2
type: Species
notes: FORMULA: C47H76N4O33X CHARGE: -1
is: HMDB00175
is: C00130
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110063#_c8a289ec_cd9a_4915_996b_6b6ab61d25ea
name: ATP5A1:ATP5B:ATP5C1:ATP5D:ATP5E
is encoded by: hsa:513
initial amount: NaN
is encoded by: hsa:514
boundary condition: true
initial concentration: NaN
has only substance units: false
constant: false
type: Species
is: SBO:0000297

http://identifiers.org/biomodels.db/MODEL1310110063#_64500271_e6ce_4773_99f2_61caffa41cb7
is: SBO:0000252
has only substance units: false
initial concentration: NaN
boundary condition: true
type: Species
constant: false
is: P07195
is encoded by: hsa:3945
initial amount: NaN
name: LDHB

metaM dgsn c
initial concentration: 1.0
initial amount: NaN
notes: FORMULA: C10H13N5O4 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00280 EHMN_ABBREVIATION: C00330
is: SBO:0000247
constant: false
is: CHEBI:17172
is: C00330
is: HMDB00085
has only substance units: false
boundary condition: false
type: Species
name: Deoxyguanosine

http://identifiers.org/biomodels.db/MODEL1310110063#_864092c6_40db_4223_ab8a_7f2b8ae9a5e8
is encoded by: hsa:3032
has part: E9KL44
is encoded by: hsa:3030
initial amount: NaN
boundary condition: true
name: HADHA:HADHB
has part: P55084
has only substance units: false
initial concentration: NaN
constant: false
type: Species
is: SBO:0000297

metaR RE1804C
product: MODEL1310110063#
kinetic law: MODEL1310110063#
reactant: MODEL1310110063#
reversible: true
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Bile acid synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:9660774 NOTES:
is described by: ECO:0000000
fast: false
name: RE1804
is: SBO:0000176

metaR FAOXC226m
kinetic law: MODEL1310110063#
product: MODEL1310110063#
reactant: MODEL1310110063#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: isomerization(C22:6)m
type: Reaction

metaM hdd2coa m
initial concentration: 1.0
name: trans-Hexadec-2-enoyl-CoA
is: HMDB03945
initial amount: NaN
is: C05272
notes: FORMULA: C37H60N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC01411 EHMN_ABBREVIATION: C05272
is: CHEBI:61526
boundary condition: false
constant: false
type: Species
has only substance units: false
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110063#_2ba9ddb8_af29_4618_8378_14b17ae6c661
constant: false
initial concentration: NaN
type: Species
has only substance units: false
boundary condition: true
initial amount: NaN
name: COQ3
is: SBO:0000252
is encoded by: hsa:51805
is: Q9NZJ6

metaR r1921
is: SBO:0000185
modifier: MODEL1310110063#
fast: false
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
kinetic law: MODEL1310110063#
reversible: false
is described by: ECO:0000000
reactant: MODEL1310110063#
name: Y+LAT2 Utilized transport
type: Reaction
product: MODEL1310110063#

metaM dectricoa x
initial concentration: 1.0
type: Species
name: 2,4,7-decatrienoylcoa
notes: FORMULA: C31H44N7O17P3S CHARGE: -4
constant: false
boundary condition: false
has only substance units: false
initial amount: NaN
is: http://identifiers.org/pubchem.compound/16019966
is: SBO:0000247

metaR ALDD21
product: MODEL1310110063#
is: SBO:0000176
modifier: MODEL1310110063#
fast: false
name: aldehyde dehydrogenase (pristanal, NAD)
type: Reaction
kinetic law: MODEL1310110063#
reversible: false
is described by: ECO:0000304
notes: GENE_ASSOCIATION: (224.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 2 AUTHORS: PMID:11591435,PMID:8528251 NOTES:NJ
is version of: http://identifiers.org/ec-code/1.2.1.3
reactant: MODEL1310110063#

metaR TRIODTHYt2
is: SBO:0000185
notes: GENE_ASSOCIATION: (6567.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12871948,PMID:7981683 NOTES:NJ
name: T3 transport via facilitated diffusion
type: Reaction
fast: false
is described by: ECO:0000269
kinetic law: MODEL1310110063#
reactant: MODEL1310110063#
product: MODEL1310110063#
modifier: MODEL1310110063#
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110063#_d792ba5c_ee1b_46b5_9ab5_f8c4ca1c2c3c
name: CHAT
is encoded by: hsa:1103
type: Species
initial concentration: NaN
initial amount: NaN
is: SBO:0000252
boundary condition: true
has only substance units: false
constant: false
is: Q6LEN6

http://identifiers.org/biomodels.db/MODEL1310110063#_9d96cf39_a73e_440c_a04b_ab71aad16bfd
has only substance units: false
initial amount: NaN
is: SBO:0000252
name: SLC1A4
is encoded by: hsa:6509
initial concentration: NaN
boundary condition: true
is: P43007
constant: false
type: Species

metaM 3aib c
name: (S)-3-aminoisobutyric acid
has only substance units: false
is: HMDB02166
initial amount: NaN
constant: false
type: Species
is: CHEBI:33094
notes: FORMULA: C4H9NO2 CHARGE: 0 INCHI: InChI=1S/C4H9NO2/c1-3(2-5)4(6)7/h3H,2,5H2,1H3,(H,6,7)/t3-/m0/s1 EHMN_ABBREVIATION: C03284
boundary condition: false
initial concentration: 1.0
is: SBO:0000247

metaM CE2424 m
constant: false
has only substance units: false
is: HMDB11123
boundary condition: false
initial concentration: 1.0
is: SBO:0000247
type: Species
initial amount: NaN
is: CHEBI:28387
name: 3-oxo-cis,cis-5,8-tetradecadienoyl-CoA
notes: FORMULA: C35H52N7O18P3S CHARGE: -4 INCHI: InChI=1/C35H56N7O18P3S/c1-4-5-6-7-8-9-10-11-12-13-23(43)18-26(45)64-17-16-37-25(44)14-15-38-33(48)30(47)35(2,3)20-57-63(54,55)60-62(52,53)56-19-24-29(59-61(49,50)51)28(46)34(58-24)42-22-41-27-31(36)39-21-40-32(27)42/h8-9,11-12,21-22,24,28-30,34,46-47H,4-7,10,13-20H2,1-3H3,(H,37,44)(H,38,48)(H,52,53)(H,54,55)(H2,36,39,40)(H2,49,50,51)/p-4/b9-8-,12-11-/t24-,28+,29+,30u,34-/m0/s1 EHMN_ABBREVIATION: CE2424

metaM c8dc c
constant: false
initial amount: NaN
initial concentration: 1.0
is: C02838
is: HMDB00791
name: suberyl carnitine
notes: FORMULA: C15H26NO6 CHARGE: -1
boundary condition: false
type: Species
is: SBO:0000247
has only substance units: false

metaR r0276
product: MODEL1310110063#
reactant: MODEL1310110063#
type: Reaction
fast: false
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/1.1.1.21
is version of: http://identifiers.org/ec-code/1.1.1.2
reversible: true
kinetic law: MODEL1310110063#
modifier: MODEL1310110063#
is: SBO:0000176
notes: GENE_ASSOCIATION: (10327.1) or (231.1) SUBSYSTEM: Purine catabolism EC Number: 1.7.1.7 Confidence Level: 0 AUTHORS: PMID:12009299,PMID:12669231 NOTES:
name: NADH:guanosine-5-phosphate oxidoreductase(deaminating) Purine metabolism EC:1.7.1.7

metaM Asn X Ser Thr l
notes: FORMULA: XH CHARGE: 0
is: HMDB00051
constant: false
is: SBO:0000247
type: Species
is: C01342
name: protein-linked asparagine residue (N-glycosylation site)
initial concentration: 1.0
boundary condition: false
has only substance units: false
initial amount: NaN
is: CHEBI:28938

metaR r2372
reversible: true
reactant: MODEL1310110063#
is described by: ECO:0000000
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
fast: false
is: SBO:0000185
kinetic law: MODEL1310110063#
type: Reaction
product: MODEL1310110063#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172 NOTES:

metaR DOCO13ECOAtxc
kinetic law: MODEL1310110063#
product: MODEL1310110063#
reactant: MODEL1310110063#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of 13-docosenoylcoa into peroxisomes
type: Reaction

metaR r0842
is described by: ECO:0000000
is: SBO:0000185
kinetic law: MODEL1310110063#
product: MODEL1310110063#
modifier: MODEL1310110063#
is version of: http://identifiers.org/ec-code/1.3.1.72
type: Reaction
reactant: MODEL1310110063#
notes: GENE_ASSOCIATION: (1718.1) SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:7050120 NOTES:
fast: false
reversible: true
name: Postulated transport reaction

metaR FBP
product: MODEL1310110063#
fast: false
reactant: MODEL1310110063#
type: Reaction
is version of: http://identifiers.org/ec-code/3.1.3.11
kinetic law: MODEL1310110063#
modifier: MODEL1310110063#
name: fructose-bisphosphatase
notes: GENE_ASSOCIATION: (2203.1) or (8789.1) SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: 3.1.3.11 Confidence Level: 0 AUTHORS: PMID:9678974 NOTES:SMP
is: SBO:0000176
is described by: ECO:0000000
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110063#_7dfc7e88_6cd2_479f_b5c5_cc689bb9dc49
is: GO:0005794
is: SBO:0000290
constant: false
size: 1.0
spatial dimensions: 3.0
name: Golgi apparatus
type: Compartment

metaR FACOAL245 1
reactant: MODEL1310110063#
modifier: MODEL1310110063#
fast: false
notes: GENE_ASSOCIATION: (2180.1) SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 4 AUTHORS: PMID:15292367 NOTES:NJ
is version of: http://identifiers.org/ec-code/6.2.1.3
is: SBO:0000176
reversible: true
name: fatty-acid--CoA ligase
type: Reaction
product: MODEL1310110063#
is described by: ECO:0000000
kinetic law: MODEL1310110063#

http://identifiers.org/biomodels.db/MODEL1310110063#_c5679771_9f70_4150_9490_86b45babfe7d
constant: false
type: Species
is encoded by: hsa:686
is: SBO:0000252
boundary condition: true
initial concentration: NaN
is: P43251
initial amount: NaN
name: BTD
has only substance units: false

metaM utp e
type: Species
has only substance units: false
boundary condition: false
is: CHEBI:46398
is: HMDB00285
initial amount: NaN
notes: FORMULA: C9H11N2O15P3 CHARGE: -4 INCHI: InChI=1S/C9H15N2O15P3/c12-5-1-2-11(9(15)10-5)8-7(14)6(13)4(24-8)3-23-28(19,20)26-29(21,22)25-27(16,17)18/h1-2,4,6-8,13-14H,3H2,(H,19,20)(H,21,22)(H,10,12,15)(H2,16,17,18)/p-4/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00077 EHMN_ABBREVIATION: C00075
is: SBO:0000247
initial concentration: 1.0
name: UTP(4-)
constant: false

http://identifiers.org/biomodels.db/MODEL1310110063#_976446bd_32d5_43e5_99d8_5558e4c7384e
is: SBO:0000252
name: NAGLU
is: P54802
type: Species
initial concentration: NaN
is encoded by: hsa:4669
constant: false
initial amount: NaN
boundary condition: true
has only substance units: false

metaM r1p c
is: SBO:0000247
initial concentration: 1.0
boundary condition: false
notes: FORMULA: C5H9O8P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00456 EHMN_ABBREVIATION: C00442
is: HMDB01489
is: CHEBI:57720
constant: false
name: alpha-D-Ribose 1-phosphate
type: Species
has only substance units: false
initial amount: NaN
is: C00442

metaR GPIAT
reactant: MODEL1310110063#
is described by: ECO:0000269
modifier: MODEL1310110063#
notes: GENE_ASSOCIATION: (284098.1) SUBSYSTEM: Phosphatidylinositol phosphate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:14517336 NOTES:EC 2.3.-.- NCD
product: MODEL1310110063#
kinetic law: MODEL1310110063#
reversible: false
fast: false
type: Reaction
name: glucosaminylphosphatidyl inositol acetyltransferase
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110063#_a6885c62_300d_479b_827e_b85115888367
has only substance units: false
is: P30566
constant: false
is encoded by: hsa:158
name: ADSL
initial concentration: NaN
type: Species
initial amount: NaN
is: SBO:0000252
boundary condition: true

metaR r2373
product: MODEL1310110063#
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:16919238,PMID:17173541,PMID:18406340,PMID:8132483 NOTES:
reactant: MODEL1310110063#
type: Reaction
fast: false
is: SBO:0000185
kinetic law: MODEL1310110063#
reversible: true
is described by: ECO:0000000

metaR EX eicostet LPAREN e RPAREN
kinetic law: MODEL1310110063#
reactant: MODEL1310110063#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: eicosatetranoic acid exchange
type: Reaction

metaR r0841
name: Free diffusion
fast: false
notes: GENE_ASSOCIATION: (7264.1) SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:16756494 NOTES:
kinetic law: MODEL1310110063#
product: MODEL1310110063#
type: Reaction
reversible: true
is: SBO:0000185
is version of: http://identifiers.org/ec-code/1.1.1.271
modifier: MODEL1310110063#
reactant: MODEL1310110063#
is described by: ECO:0000000

metaM dgsn e
constant: false
boundary condition: false
is: SBO:0000247
is: CHEBI:17172
initial amount: NaN
has only substance units: false
initial concentration: 1.0
is: C00330
type: Species
name: Deoxyguanosine
notes: FORMULA: C10H13N5O4 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00280 EHMN_ABBREVIATION: C00330
is: HMDB00085

http://identifiers.org/biomodels.db/MODEL1310110063#_20e43f93_9da9_4ebf_af34_1a9f5b14af1d
initial concentration: NaN
initial amount: NaN
constant: false
name: TXNRD2
is: SBO:0000252
boundary condition: true
type: Species
has only substance units: false
is encoded by: hsa:10587

metaR RE0915E
reversible: true
modifier: MODEL1310110063#
product: MODEL1310110063#
is version of: http://identifiers.org/ec-code/3.2.1.1
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (280.1) or (84569.1) or (276.1) or (277.1) or (278.1) or (279.1) or (276.1) or (277.1) or (278.1) or (279.1) SUBSYSTEM: Starch and sucrose metabolism EC Number: 3.2.1.1 Confidence Level: 0 AUTHORS: PMID:385176,PMID:8528071,PMID:890964 NOTES:
type: Reaction
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.2.1.17
reactant: MODEL1310110063#
kinetic law: MODEL1310110063#
name: RE0915
fast: false

metaR PROt4
name: Na+/Proline-L symporter
reactant: MODEL1310110063#
product: MODEL1310110063#
type: Reaction
fast: false
notes: GENE_ASSOCIATION: (55089.1) or (81539.1) or (54407.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10747860,PMID:10891391,PMID:10930503,PMID:11325958,PMID:11342143,PMID:11414754 NOTES:JLR
modifier: MODEL1310110063#
is: SBO:0000185
kinetic law: MODEL1310110063#
reversible: false
is described by: ECO:0000269

metaR S6TASE20ly
is described by: ECO:0000000
fast: false
is version of: http://identifiers.org/ec-code/3.1.6.14
modifier: MODEL1310110063#
notes: GENE_ASSOCIATION: (2799.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.1.6.14 Confidence Level: 4 AUTHORS: PMID:3196333,PMID:3689314,PMID:3689315 NOTES:NCD
is: SBO:0000176
product: MODEL1310110063#
kinetic law: MODEL1310110063#
reversible: true
type: Reaction
reactant: MODEL1310110063#
name: N-acetylglucosamine-6-sulfatase, lysosomal

metaR CHSTEROLtrc
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: PMID: 11229876 NOTES:newly synthesized cholesterol may either be incorporated into membrane or transported out of enterocytes.
is: SBO:0000185
kinetic law: MODEL1310110063#
reversible: true
type: Reaction
product: MODEL1310110063#
is described by: ECO:0000134
name: transport of cholesterol into the cytosol
fast: false
reactant: MODEL1310110063#

http://identifiers.org/biomodels.db/MODEL1310110063#_2a97b719_5f53_415c_9c22_3024cb9cb927
initial amount: NaN
boundary condition: true
name: ACSL5
has only substance units: false
is: Q9ULC5
type: Species
is encoded by: hsa:51703
initial concentration: NaN
is: SBO:0000252
constant: false

http://identifiers.org/biomodels.db/MODEL1310110063#_f116ca34_d5af_4863_8135_0deffbec192a
has only substance units: false
initial amount: NaN
is encoded by: hsa:10637
is: O75610
initial concentration: NaN
type: Species
constant: false
name: LEFTY1
boundary condition: true
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110063#_cd6c4198_5123_40ee_8898_888a8e9053f0
is: Q9UNK4
initial amount: NaN
has only substance units: false
initial concentration: NaN
name: PLA2G2D
constant: false
type: Species
boundary condition: true
is: SBO:0000252
is encoded by: hsa:26279

http://identifiers.org/biomodels.db/MODEL1310110063#_f703abd3_d667_4888_93d6_335fc7e39842
is: B4DJQ3
has only substance units: false
type: Species
name: SHMT2
initial amount: NaN
is: SBO:0000252
constant: false
is encoded by: hsa:6472
initial concentration: NaN
boundary condition: true

metaR DOLASNT Uer
is described by: ECO:0000000
product: MODEL1310110063#
is: SBO:0000176
reactant: MODEL1310110063#
type: Reaction
fast: false
modifier: MODEL1310110063#
reversible: false
is version of: http://identifiers.org/ec-code/2.4.1.119
name: Dolichyl-diphosphooligosaccharide:protein-L-asparagine oligopolysaccharidotransferase (uterus)
kinetic law: MODEL1310110063#
notes: GENE_ASSOCIATION: (6185.1 and 1650.1 and 6184.1 and 1603.1) SUBSYSTEM: N-glycan synthesis EC Number: 2.4.1.119 Confidence Level: 0 AUTHORS: PMID:8413235,PMID:9367678 NOTES:NCD

metaM dmnoncrn m
initial concentration: 1.0
constant: false
boundary condition: false
initial amount: NaN
type: Species
name: 4,8 dimethylnonanoyl carnitine
has only substance units: false
is: SBO:0000247
is: HMDB06202
notes: FORMULA: C18H37NO4 CHARGE: 0 INCHI: InChI=1/C18H35NO4/c1-14(2)8-7-9-15(3)10-11-18(22)23-16(12-17(20)21)13-19(4,5)6/h14-16H,7-13H2,1-6H3

metaR KSIt
type: Reaction
reactant: MODEL1310110063#
kinetic law: MODEL1310110063#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:NCD
reversible: false
product: MODEL1310110063#
is: SBO:0000185
is described by: ECO:0000000
fast: false
name: keratan sulfate I transport, golgi to extracellular

http://identifiers.org/biomodels.db/MODEL1310110063#_71e441b5_d5ec_486f_b3b9_d8bf876b4478
is encoded by: hsa:728441
type: Species
initial amount: NaN
boundary condition: true
is: SBO:0000252
initial concentration: NaN
has only substance units: false
name: GGT2
constant: false

metaR r2371
is described by: ECO:0000000
reversible: true
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172 NOTES:
product: MODEL1310110063#
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
reactant: MODEL1310110063#
kinetic law: MODEL1310110063#
type: Reaction
is: SBO:0000185

metaR AMPDA
reversible: false
is: SBO:0000176
notes: GENE_ASSOCIATION: (271.2) or (270.1) or (271.1) or (272.1) or (271.3) SUBSYSTEM: Nucleotide interconversion EC Number: 3.5.4.6 Confidence Level: 4 AUTHORS: PMID:1400401,PMID:2345176 NOTES:
kinetic law: MODEL1310110063#
reactant: MODEL1310110063#
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/3.5.4.6
name: Adenosine monophosphate deaminase
product: MODEL1310110063#
type: Reaction
fast: false
modifier: MODEL1310110063#

metaM 4nph c
name: 4-nitrophenolate
initial concentration: 1.0
is: SBO:0000247
has only substance units: false
notes: FORMULA: C6H5NO3 CHARGE: 0 INCHI: InChI=1S/C6H5NO3/c8-6-3-1-5(2-4-6)7(9)10/h1-4,8H/p-1 HEPATONET_1.0_ABBREVIATION: HC00570 EHMN_ABBREVIATION: C00870
initial amount: NaN
type: Species
constant: false
is: CHEBI:57917
boundary condition: false
is: HMDB01232

http://identifiers.org/biomodels.db/MODEL1310110063#_dd86e5c5_42fc_4f46_a722_3839a74d6b95
constant: false
initial amount: NaN
type: Species
name: SLC7A10
is: SBO:0000252
initial concentration: NaN
is: Q9NS82
is encoded by: hsa:56301
boundary condition: true
has only substance units: false

metaM HC01434 x
initial concentration: 1.0
type: Species
has only substance units: false
is: CHEBI:58931
initial amount: NaN
name: oxalatosuccinate(3-)
is: SBO:0000247
boundary condition: false
notes: FORMULA: C6H3O7 CHARGE: -3 INCHI: InChI=1S/C6H6O7/c7-3(8)1-2(5(10)11)4(9)6(12)13/h2H,1H2,(H,7,8)(H,10,11)(H,12,13)/p-3 EHMN_ABBREVIATION: C05379
constant: false

metaM HC02202 c
type: Species
is: SBO:0000247
has only substance units: false
initial concentration: 1.0
initial amount: NaN
name: prostaglandin A1(1-)
is: CHEBI:57398
boundary condition: false
notes: FORMULA: C20H31O4 CHARGE: -1 INCHI: InChI=1S/C20H32O4/c1-2-3-6-9-17(21)14-12-16-13-15-19(22)18(16)10-7-4-5-8-11-20(23)24/h12-18,21H,2-11H2,1H3,(H,23,24)/p-1/b14-12+/t16-,17-,18+/m0/s1 EHMN_ABBREVIATION: C04685
constant: false

metaR ORNDC
reversible: false
notes: GENE_ASSOCIATION: (4953.1) SUBSYSTEM: Urea cycle EC Number: 4.1.1.17 Confidence Level: 4 AUTHORS: PMID:2317811 NOTES:JLR- added proton to balance
is version of: http://identifiers.org/ec-code/4.1.1.17
reactant: MODEL1310110063#
kinetic law: MODEL1310110063#
is described by: ECO:0000269
type: Reaction
product: MODEL1310110063#
modifier: MODEL1310110063#
name: Ornithine Decarboxylase
fast: false
is: SBO:0000176

metaR SPMTDe
is described by: ECO:0000134
kinetic law: MODEL1310110063#
is: SBO:0000185
reversible: true
product: MODEL1310110063#
reactant: MODEL1310110063#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
fast: false
name: SPMTDe
type: Reaction

metaM 2hb c
is: SBO:0000247
type: Species
notes: FORMULA: C4H7O3 CHARGE: -1 INCHI: InChI=1S/C4H8O3/c1-2-3(5)4(6)7/h3,5H,2H2,1H3,(H,6,7) HEPATONET_1.0_ABBREVIATION: HC01669 EHMN_ABBREVIATION: C05984
has only substance units: false
is: CHEBI:1148
is: HMDB00008
constant: false
boundary condition: false
initial amount: NaN
name: 2-Hydroxybutyrate
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110063#_a07170f2_0aa1_485a_ae7d_13f7947558b2
constant: false
initial concentration: NaN
is encoded by: hsa:80864
name: EGFL8
boundary condition: true
is: Q99944
initial amount: NaN
type: Species
is: SBO:0000252
has only substance units: false

metaR SGALSIDEtl
is described by: ECO:0000000
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 1 AUTHORS: NOTES:unknown mechanism for transport - however must get to other intracellular compartments (e.g. lysosome for degradation) NJ
kinetic law: MODEL1310110063#
fast: false
reactant: MODEL1310110063#
product: MODEL1310110063#
type: Reaction
is: SBO:0000185
name: sgalside hs intracellular transport

metaR STS1
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.1.6.2
name: Steryl-sulfatase
notes: GENE_ASSOCIATION: (412.1) SUBSYSTEM: Steroid metabolism EC Number: 3.1.6.2 Confidence Level: 4 AUTHORS: PMID:2668275,PMID:6957717 NOTES:NJ
reactant: MODEL1310110063#
fast: false
kinetic law: MODEL1310110063#
type: Reaction
is described by: ECO:0000269
modifier: MODEL1310110063#
reversible: false
product: MODEL1310110063#

metaR UPPN
type: Reaction
is version of: http://identifiers.org/ec-code/3.5.1.6
reversible: false
is described by: ECO:0000269
kinetic law: MODEL1310110063#
notes: GENE_ASSOCIATION: (51733.1) SUBSYSTEM: Pyrimidine catabolism EC Number: 3.5.1.6 Confidence Level: 4 AUTHORS: PMID:10542323,PMID:12450676 NOTES:SAB balanced
fast: false
reactant: MODEL1310110063#
is: SBO:0000176
name: b-ureidopropionase
product: MODEL1310110063#
modifier: MODEL1310110063#

metaM pe hs e
name: phosphatidylethanolamine
notes: FORMULA: C5H12NO4PFULLRCO2FULLR2CO2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC02002 EHMN_ABBREVIATION: C00350
initial concentration: 1.0
has only substance units: false
boundary condition: false
constant: false
is: SBO:0000247
initial amount: NaN
type: Species
is: CHEBI:16038

metaR r2376
is described by: ECO:0000000
type: Reaction
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:16919238,PMID:17173541,PMID:18406340,PMID:8132483 NOTES:
product: MODEL1310110063#
reactant: MODEL1310110063#
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
kinetic law: MODEL1310110063#
fast: false
is: SBO:0000185

metaR r1548
is described by: ECO:0000000
fast: false
reversible: true
reactant: MODEL1310110063#
product: MODEL1310110063#
type: Reaction
kinetic law: MODEL1310110063#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1

http://identifiers.org/biomodels.db/MODEL1310110063#_3ce06a0c_7ea6_4c2b_a603_a3dafa7f91c7
boundary condition: true
is: SBO:0000252
name: SLC15A2
constant: false
initial concentration: NaN
is: Q16348
has only substance units: false
type: Species
is encoded by: hsa:6565
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110063#_4674fe46_ec0d_4f51_ae7b_339d6c80bd93
name: PANK1
boundary condition: true
constant: false
has only substance units: false
type: Species
initial concentration: NaN
is encoded by: hsa:53354
initial amount: NaN
is: SBO:0000252

metaR PHEMEt
is described by: ECO:0000269
type: Reaction
reactant: MODEL1310110063#
reversible: false
is: SBO:0000185
fast: false
modifier: MODEL1310110063#
product: MODEL1310110063#
name: heme transport
notes: GENE_ASSOCIATION: (113235.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:16143108 NOTES:NCD
kinetic law: MODEL1310110063#

metaM CE5236 c
initial concentration: 1.0
is: HMDB03952
has only substance units: false
is: CHEBI:28002
type: Species
notes: FORMULA: C9H13N5O3 CHARGE: 0 INCHI: InChI=1/C9H13N5O3/c1-3-5(15)4-2-11-6-9(14-4,17-3)7(16)13-8(10)12-6/h3-5,14-15H,2H2,1H3,(H3,10,11,12,13,16)/p+1/t3-,4u,5+,9u/m0/s1 EHMN_ABBREVIATION: CE5236
is: SBO:0000247
boundary condition: false
constant: false
initial amount: NaN
name: O2'-4a-cyclic-tetrahydrobiopterin

metaR LNELDCCPT2
kinetic law: MODEL1310110063#
notes: GENE_ASSOCIATION: (1376.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: NOTES:NJ
type: Reaction
reversible: false
is: SBO:0000176
product: MODEL1310110063#
is described by: ECO:0000000
fast: false
modifier: MODEL1310110063#
is version of: http://identifiers.org/ec-code/2.3.1.21
reactant: MODEL1310110063#
name: carnitine transferase

metaR STS2
type: Reaction
reversible: false
fast: false
is version of: http://identifiers.org/ec-code/3.1.6.2
kinetic law: MODEL1310110063#
is: SBO:0000176
name: Steryl-sulfatase
is described by: ECO:0000269
reactant: MODEL1310110063#
product: MODEL1310110063#
notes: GENE_ASSOCIATION: (412.1) SUBSYSTEM: Steroid metabolism EC Number: 3.1.6.2 Confidence Level: 4 AUTHORS: PMID:2668275,PMID:6957717 NOTES:NJ
modifier: MODEL1310110063#

metaM pre prot r
name: glycophosphatidylinositol (GPI)-anchored protein precursor
is: CHEBI:16240
notes: FORMULA: XY CHARGE: 0
is: SBO:0000247
is: HMDB03125
initial concentration: 1.0
boundary condition: false
constant: false
type: Species
initial amount: NaN
has only substance units: false

metaR ADSS
notes: GENE_ASSOCIATION: (159.1) or (122622.1) or (122622.2) SUBSYSTEM: Nucleotide interconversion EC Number: 6.3.4.4 Confidence Level: 2 AUTHORS: PMID:1592113 NOTES:r0277
reversible: false
product: MODEL1310110063#
is described by: ECO:0000134
name: adenylosuccinate synthase
is: SBO:0000176
fast: false
reactant: MODEL1310110063#
is version of: http://identifiers.org/ec-code/6.3.4.4
modifier: MODEL1310110063#
kinetic law: MODEL1310110063#
type: Reaction

metaR r2377
reactant: MODEL1310110063#
kinetic law: MODEL1310110063#
fast: false
type: Reaction
reversible: true
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:16919238,PMID:17173541,PMID:18406340,PMID:8132483 NOTES:
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
is described by: ECO:0000000
product: MODEL1310110063#

metaR CYSGLNNaEx
kinetic law: MODEL1310110063#
reversible: false
name: L-cysteine/L-glutamine Na-dependent exchange (Cys-L in)
notes: GENE_ASSOCIATION: (6510.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14530974 NOTES:SAB see Kanai and Hediger 2004 (2003), PMID 14530974
product: MODEL1310110063#
modifier: MODEL1310110063#
is described by: ECO:0000269
is: SBO:0000185
reactant: MODEL1310110063#
fast: false
type: Reaction

metaR r1549
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reversible: true
type: Reaction
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is described by: ECO:0000000
reactant: MODEL1310110063#
kinetic law: MODEL1310110063#
is: SBO:0000185
product: MODEL1310110063#

metaM ha pre1 e
constant: false
notes: FORMULA: C14H20NO11 CHARGE: -1 INCHI: InChI=1S/C14H21NO11/c1-4(17)15-8-11(10(20)7(3-16)24-13(8)23)26-14-9(19)5(18)2-6(25-14)12(21)22/h2,5,7-11,13-14,16,18-20,23H,3H2,1H3,(H,15,17)(H,21,22)/t5-,7+,8+,9+,10+,11+,13+,14-/m0/s1
boundary condition: false
initial concentration: 1.0
has only substance units: false
is: SBO:0000247
initial amount: NaN
type: Species
name: hyaluronan biosynthesis, precursor 1
is: CHEBI:16126

metaM apoC Lys btn c
boundary condition: false
is: CHEBI:32551
initial amount: NaN
is: HMDB00182
notes: FORMULA: C16H27N4O3SX CHARGE: 0
type: Species
has only substance units: false
constant: false
name: Holocarboxylase (biotin covalent bound to Lys residue of apoC)
is: SBO:0000247
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110063#_f0aa756e_450e_452c_aaa2_7095940bba61
is: SBO:0000252
type: Species
name: ELOVL1
boundary condition: true
constant: false
initial concentration: NaN
is: Q9BW60
is encoded by: hsa:64834
initial amount: NaN
has only substance units: false

metaM 5forthf c
is: HMDB01534
boundary condition: false
is: SBO:0000247
type: Species
has only substance units: false
constant: false
name: 5-Formiminotetrahydrofolate
initial concentration: 1.0
notes: FORMULA: C20H22N8O6 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00483 EHMN_ABBREVIATION: C00664
initial amount: NaN
is: CHEBI:57456
is: C00664

metaM HC02202 e
boundary condition: false
is: SBO:0000247
notes: FORMULA: C20H31O4 CHARGE: -1 INCHI: InChI=1S/C20H32O4/c1-2-3-6-9-17(21)14-12-16-13-15-19(22)18(16)10-7-4-5-8-11-20(23)24/h12-18,21H,2-11H2,1H3,(H,23,24)/p-1/b14-12+/t16-,17-,18+/m0/s1 EHMN_ABBREVIATION: C04685
initial amount: NaN
has only substance units: false
is: CHEBI:57398
name: prostaglandin A1(1-)
initial concentration: 1.0
constant: false
type: Species

metaR EX 3octdeccrn
kinetic law: MODEL1310110063#
reactant: MODEL1310110063#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for 3-hydroxyoctadecanoyl carnitine
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110063#_16c20126_f4ff_465f_bcc7_634922cd1046
initial amount: NaN
type: Species
is: SBO:0000252
constant: false
is: Q53TV9
name: RPE
boundary condition: true
has only substance units: false
is encoded by: hsa:6120
initial concentration: NaN

metaM 4nph e
is: CHEBI:57917
has only substance units: false
notes: FORMULA: C6H5NO3 CHARGE: 0 INCHI: InChI=1S/C6H5NO3/c8-6-3-1-5(2-4-6)7(9)10/h1-4,8H/p-1 HEPATONET_1.0_ABBREVIATION: HC00570 EHMN_ABBREVIATION: C00870
name: 4-nitrophenolate
initial amount: NaN
initial concentration: 1.0
boundary condition: false
is: SBO:0000247
type: Species
is: HMDB01232
constant: false

metaR LNELDCCPT1
modifier: MODEL1310110063#
reversible: false
product: MODEL1310110063#
notes: GENE_ASSOCIATION: (1375.1) or (1375.3) or (1375.4) or (126129.1) or (1374.1) or (1375.2) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.21 Confidence Level: 4 AUTHORS: NOTES:NJ
type: Reaction
fast: false
is version of: http://identifiers.org/ec-code/2.3.1.21
is described by: ECO:0000269
reactant: MODEL1310110063#
is: SBO:0000176
kinetic law: MODEL1310110063#
name: carnitine O-palmitoyltransferase

metaM 3aib e
is: SBO:0000247
name: (S)-3-aminoisobutyric acid
initial amount: NaN
boundary condition: false
has only substance units: false
initial concentration: 1.0
type: Species
constant: false
is: CHEBI:33094
is: HMDB02166
notes: FORMULA: C4H9NO2 CHARGE: 0 INCHI: InChI=1S/C4H9NO2/c1-3(2-5)4(6)7/h3H,2,5H2,1H3,(H,6,7)/t3-/m0/s1 EHMN_ABBREVIATION: C03284

metaR CYTK8n
reversible: true
kinetic law: MODEL1310110063#
is: SBO:0000176
product: MODEL1310110063#
name: cytidylate kinase (CMP,dATP),nuclear
fast: false
reactant: MODEL1310110063#
type: Reaction
is version of: http://identifiers.org/ec-code/2.7.4.14
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
is described by: ECO:0000269
modifier: MODEL1310110063#

http://identifiers.org/biomodels.db/MODEL1310110063#_15b795f0_6b49_41e9_ba57_4e0a7c234d42
boundary condition: true
is: SBO:0000252
constant: false
initial concentration: NaN
is encoded by: hsa:1120
name: CHKB
initial amount: NaN
has only substance units: false
is: A0PJM6
type: Species

http://identifiers.org/biomodels.db/MODEL1310110063#_c12d913f_293d_437b_ae9a_0f32d240eaef
is: Q9Y6T7
boundary condition: true
constant: false
initial concentration: NaN
has only substance units: false
is: SBO:0000252
initial amount: NaN
name: DGKB
is encoded by: hsa:1607
type: Species

metaM ksii core4 pre1 g
constant: false
is: SBO:0000247
initial concentration: 1.0
type: Species
has only substance units: false
boundary condition: false
initial amount: NaN
is: CHEBI:28067
name: keratan sulfate II biosynthesis, precursor 1
notes: FORMULA: C36H60N3O25X CHARGE: 0

metaR r2374
reversible: true
product: MODEL1310110063#
reactant: MODEL1310110063#
is described by: ECO:0000000
is: SBO:0000185
fast: false
kinetic law: MODEL1310110063#
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:16919238,PMID:17173541,PMID:18406340,PMID:8132483 NOTES:
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110063#_626bce6b_f428_43e0_8b74_1c3c0337dd69
boundary condition: true
is: P04746
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:279
type: Species
constant: false
is: SBO:0000252
has only substance units: false
name: AMY2A

http://identifiers.org/biomodels.db/MODEL1310110063#_6a90f8cb_522d_468b_ad96_8b58ce2e9121
boundary condition: true
name: HSD3B7
is encoded by: hsa:80270
is: Q9H2F3
type: Species
is: SBO:0000252
initial concentration: NaN
initial amount: NaN
has only substance units: false
constant: false

metaR TYMSFt
type: Reaction
kinetic law: MODEL1310110063#
reactant: MODEL1310110063#
reversible: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 1 AUTHORS: NOTES:SAB excretion of tyramine sulfate
product: MODEL1310110063#
is described by: ECO:0000000
is: SBO:0000185
name: Tyramine O-sulfate transport (diffusion)
fast: false

http://identifiers.org/biomodels.db/MODEL1310110063#_4520a6a7_b63d_43f9_b84b_69b97c95d1d8
name: MTMR3
initial amount: NaN
initial concentration: NaN
boundary condition: true
is: SBO:0000252
constant: false
is encoded by: hsa:8897
type: Species
has only substance units: false

metaR NACHEX17ly
name: beta-N-acetylhexosaminidase, lysosomal
modifier: MODEL1310110063#
reactant: MODEL1310110063#
is: SBO:0000176
fast: false
is described by: ECO:0000000
type: Reaction
notes: GENE_ASSOCIATION: (3074.1) or (3073.1) or (3073.1 and 3074.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.52 Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12706724,PMID:8993162 NOTES:NCD
reversible: false
product: MODEL1310110063#
is version of: http://identifiers.org/ec-code/3.2.1.52
kinetic law: MODEL1310110063#

http://identifiers.org/biomodels.db/MODEL1310110063#_995b2bff_794c_4952_8d75_925f109c2d55
is encoded by: hsa:50484
is: Q7LG56
initial concentration: NaN
type: Species
initial amount: NaN
constant: false
name: RRM2B
boundary condition: true
is: SBO:0000252
has only substance units: false

metaR PROSTGH2t
product: MODEL1310110063#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:12827517,PMID:12883891,PMID:9187257 NOTES:
fast: false
kinetic law: MODEL1310110063#
reversible: true
is: SBO:0000185
is described by: ECO:0000269
type: Reaction
name: Prostaglandin H2 transport
reactant: MODEL1310110063#

metaM andrstandn r
has only substance units: false
notes: FORMULA: C19H28O2 CHARGE: 0 INCHI: InChI=1S/C19H28O2/c1-18-9-7-13(20)11-12(18)3-4-14-15-5-6-17(21)19(15,2)10-8-16(14)18/h12,14-16H,3-11H2,1-2H3/t12-,14-,15-,16-,18-,19-/m0/s1 EHMN_ABBREVIATION: C00674
is: SBO:0000247
type: Species
constant: false
is: CHEBI:15994
initial concentration: 1.0
name: 5alpha-androstane-3,17-dione
is: HMDB00899
boundary condition: false
initial amount: NaN

metaR HPDCACRNCPT2
reactant: MODEL1310110063#
type: Reaction
product: MODEL1310110063#
notes: GENE_ASSOCIATION: (1376.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: PMID:11274214,PMID:1528846,PMID:1988962 NOTES:NJ
is: SBO:0000176
name: heptadecanoate transport into the mitochondria
kinetic law: MODEL1310110063#
modifier: MODEL1310110063#
is described by: ECO:0000000
reversible: false
is version of: http://identifiers.org/ec-code/2.3.1.21
fast: false

metaR NODe
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
fast: false
kinetic law: MODEL1310110063#
name: NODe
product: MODEL1310110063#
reactant: MODEL1310110063#
type: Reaction
is: SBO:0000185
is described by: ECO:0000134

metaM m2mpdol U c
is: SBO:0000247
type: Species
constant: false
notes: FORMULA: C1365H2240N20O320P20 CHARGE: -20
initial concentration: 1.0
boundary condition: false
initial amount: NaN
has only substance units: false
name: (alpha-D-mannosyl)2-beta-D-mannosyl-diacetylchitobiosyldiphosphodolichol, human uterine homolog
is: CHEBI:28049

http://identifiers.org/biomodels.db/MODEL1310110063#_e111ebcf_72a6_418d_8a36_23e1bb5e858e
has only substance units: false
boundary condition: true
is encoded by: hsa:8654
initial concentration: NaN
constant: false
initial amount: NaN
is: G5E9C5
is: SBO:0000252
type: Species
name: PDE5A

http://identifiers.org/biomodels.db/MODEL1310110063#_1520cc83_5a3f_417c_b716_b5ea6c77f255
boundary condition: true
initial amount: NaN
type: Species
is: P00390
is: SBO:0000252
constant: false
name: GSR
is encoded by: hsa:2936
initial concentration: NaN
has only substance units: false

metaM xol7ah2al c
type: Species
is: SBO:0000247
notes: FORMULA: C27H46O3 CHARGE: 0 INCHI: InChI=1S/C27H46O3/c1-17(16-28)6-5-7-18(2)21-8-9-22-25-23(11-13-27(21,22)4)26(3)12-10-20(29)14-19(26)15-24(25)30/h16-25,29-30H,5-15H2,1-4H3/t17?,18-,19+,20-,21-,22+,23+,24-,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01454 EHMN_ABBREVIATION: C05445
constant: false
has only substance units: false
initial amount: NaN
name: 3alpha,7alpha-dihydroxy-5beta-cholestan-26-al
initial concentration: 1.0
is: CHEBI:27428
boundary condition: false
is: HMDB06894

http://identifiers.org/biomodels.db/MODEL1310110063#_2aea3a88_3ada_455c_b251_591ae877405a
initial concentration: NaN
type: Species
initial amount: NaN
has only substance units: false
is encoded by: hsa:114
is: SBO:0000252
boundary condition: true
is: Q4F7X0
constant: false
name: ADCY8

metaR r2375
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
product: MODEL1310110063#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:16919238,PMID:17173541,PMID:18406340,PMID:8132483 NOTES:
reactant: MODEL1310110063#
is: SBO:0000185
type: Reaction
fast: false
kinetic law: MODEL1310110063#
reversible: true
is described by: ECO:0000000

metaR RE2651R
reversible: true
is: SBO:0000176
type: Reaction
is described by: ECO:0000000
fast: false
kinetic law: MODEL1310110063#
product: MODEL1310110063#
notes: GENE_ASSOCIATION: SUBSYSTEM: Vitamin A metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:9647871 NOTES:
reactant: MODEL1310110063#
name: RE2651

metaR SARCStex
reversible: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:5096515 NOTES:MM
kinetic law: MODEL1310110063#
product: MODEL1310110063#
is described by: ECO:0000000
type: Reaction
fast: false
reactant: MODEL1310110063#
name: Sarcosine transport (extracellular to cytosol)
is: SBO:0000185

metaM h2o r
has only substance units: false
type: Species
is: SBO:0000247
is: CHEBI:15377
name: H2O
is: HMDB02111
is: C00001
initial concentration: 1.0
constant: false
notes: FORMULA: H2O CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00011 EHMN_ABBREVIATION: C00001
initial amount: NaN
boundary condition: false

metaR FAOXC61C4m
kinetic law: MODEL1310110063#
product: MODEL1310110063#
reactant: MODEL1310110063#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C6:1-->C4:0)m
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110063#_39fa736b_c321_446b_9af3_df53b11b653a
type: Species
is: SBO:0000252
is: Q53HE2
boundary condition: true
constant: false
name: TPI1
has only substance units: false
initial concentration: NaN
is encoded by: hsa:7167
initial amount: NaN

metaR LYStn
is: SBO:0000185
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: NOTES:IT
type: Reaction
kinetic law: MODEL1310110063#
name: L-lysine transport, nuclear
fast: false
is described by: ECO:0000000
reactant: MODEL1310110063#
product: MODEL1310110063#

http://identifiers.org/biomodels.db/MODEL1310110063#_3b49540e_e3b0_4227_af7f_c23ea39cc293
is: P34896
constant: false
boundary condition: true
name: SHMT1
type: Species
initial concentration: NaN
is: SBO:0000252
has only substance units: false
initial amount: NaN
is encoded by: hsa:6470

metaR r1660
is: SBO:0000185
product: MODEL1310110063#
reactant: MODEL1310110063#
kinetic law: MODEL1310110063#
type: Reaction
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reversible: true
is described by: ECO:0000000
modifier: MODEL1310110063#
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
fast: false

metaM cdp n
name: CDP(3-)
constant: false
initial concentration: 1.0
is: SBO:0000247
boundary condition: false
is: HMDB01546
is: CHEBI:58069
has only substance units: false
initial amount: NaN
notes: FORMULA: C9H12N3O11P2 CHARGE: -3 INCHI: InChI=1S/C9H15N3O11P2/c10-5-1-2-12(9(15)11-5)8-7(14)6(13)4(22-8)3-21-25(19,20)23-24(16,17)18/h1-2,4,6-8,13-14H,3H2,(H,19,20)(H2,10,11,15)(H2,16,17,18)/p-3/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00110 EHMN_ABBREVIATION: C00112
type: Species

metaR EX fe2 LPAREN e RPAREN
kinetic law: MODEL1310110063#
reactant: MODEL1310110063#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: EX_fe2(u)
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110063#_f405898a_2728_44de_83a5_f3abb87c5e17
name: SLC4A1
constant: false
initial concentration: NaN
is encoded by: hsa:6521
is: SBO:0000252
has only substance units: false
is: P02730
type: Species
initial amount: NaN
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110063#_bafe153f_f4a0_459f_a859_c8d6cf32956f
is: SBO:0000252
name: ENTPD8
initial concentration: NaN
initial amount: NaN
boundary condition: true
has only substance units: false
is encoded by: hsa:377841
type: Species
is: Q5MY95
constant: false

metaR H2CO3D
is version of: http://identifiers.org/ec-code/4.2.1.1
product: MODEL1310110063#
notes: GENE_ASSOCIATION: (761.1) or (771.1) or (377677.1) or (762.1) or (766.2) or (23632.1) or (766.1) or (771.2) or (759.1) or (768.1) or (760.1) SUBSYSTEM: Miscellaneous EC Number: 4.2.1.1 Confidence Level: 0 AUTHORS: PMID:11101628,PMID:11172051,PMID:11676494,PMID:14600151,PMID:7574487 NOTES:tv
reactant: MODEL1310110063#
name: carboxylic acid dissociation
is: SBO:0000176
modifier: MODEL1310110063#
reversible: true
is described by: ECO:0000000
fast: false
type: Reaction
kinetic law: MODEL1310110063#

metaR LINKDEG4ly
is: SBO:0000176
name: degradation of proteoglycan linkage region, lysosomal
type: Reaction
reactant: MODEL1310110063#
fast: false
is described by: ECO:0000000
product: MODEL1310110063#
notes: GENE_ASSOCIATION: SUBSYSTEM: Chondroitin sulfate degradation EC Number: Confidence Level: 2 AUTHORS: PMID:8993162 NOTES:NCD
kinetic law: MODEL1310110063#
reversible: false

metaM dpcoa m
has only substance units: false
initial amount: NaN
is: CHEBI:57328
notes: FORMULA: C21H33N7O13P2S CHARGE: -2 INCHI: InChI=1S/C21H35N7O13P2S/c1-21(2,16(32)19(33)24-4-3-12(29)23-5-6-44)8-39-43(36,37)41-42(34,35)38-7-11-14(30)15(31)20(40-11)28-10-27-13-17(22)25-9-26-18(13)28/h9-11,14-16,20,30-32,44H,3-8H2,1-2H3,(H,23,29)(H,24,33)(H,34,35)(H,36,37)(H2,22,25,26)/p-2/t11-,14-,15-,16+,20-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00575 EHMN_ABBREVIATION: C00882
boundary condition: false
type: Species
is: SBO:0000247
constant: false
is: HMDB01373
initial concentration: 1.0
name: 3'-dephospho-CoA(2-)

metaM leu L c
is: CHEBI:15603
is: HMDB00687
boundary condition: false
type: Species
initial concentration: 1.0
constant: false
has only substance units: false
notes: FORMULA: C6H13NO2 CHARGE: 0 INCHI: InChI=1S/C6H13NO2/c1-4(2)3-5(7)6(8)9/h4-5H,3,7H2,1-2H3,(H,8,9)/t5-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00121 EHMN_ABBREVIATION: C00123
is: SBO:0000247
initial amount: NaN
name: L-leucine

metaM aacoa m
boundary condition: false
is: HMDB01484
initial concentration: 1.0
name: acetoacetyl-CoA(4-)
is: SBO:0000247
notes: FORMULA: C25H36N7O18P3S CHARGE: -4 INCHI: InChI=1S/C25H40N7O18P3S/c1-13(33)8-16(35)54-7-6-27-15(34)4-5-28-23(38)20(37)25(2,3)10-47-53(44,45)50-52(42,43)46-9-14-19(49-51(39,40)41)18(36)24(48-14)32-12-31-17-21(26)29-11-30-22(17)32/h11-12,14,18-20,24,36-37H,4-10H2,1-3H3,(H,27,34)(H,28,38)(H,42,43)(H,44,45)(H2,26,29,30)(H2,39,40,41)/p-4/t14-,18-,19-,20+,24-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00282 EHMN_ABBREVIATION: C00332
initial amount: NaN
type: Species
constant: false
is: CHEBI:57286
has only substance units: false

metaM c8dc e
initial concentration: 1.0
constant: false
is: HMDB00791
is: C02838
has only substance units: false
boundary condition: false
type: Species
notes: FORMULA: C15H26NO6 CHARGE: -1
initial amount: NaN
is: SBO:0000247
name: suberyl carnitine

http://identifiers.org/biomodels.db/MODEL1310110063#_209a08e2_7b4b_4144_ab30_ff27df5ebdaf
initial amount: NaN
type: Species
initial concentration: NaN
is encoded by: hsa:4717
name: NDUFC1
is: SBO:0000252
boundary condition: true
has only substance units: false
constant: false
is: O43677

metaM Rtotal2coa c
is: SBO:0000247
has only substance units: false
type: Species
name: R total 2 coenzyme A
initial amount: NaN
initial concentration: 1.0
is: HMDB01564
constant: false
notes: FORMULA: CO2FULLR2C21H31N7O15P3S CHARGE: -4
boundary condition: false
is: CHEBI:57876

metaM ksii core4 deg2 l
boundary condition: false
initial concentration: 1.0
is: CHEBI:12936
initial amount: NaN
notes: FORMULA: C78H127N6O61S2X CHARGE: -2
is: SBO:0000247
is: HMDB00143
name: keratan sulfate II (core 4-linked), degradation product 2
has only substance units: false
type: Species
constant: false

metaM udp n
type: Species
is: HMDB00295
initial concentration: 1.0
constant: false
has only substance units: false
is: SBO:0000247
boundary condition: false
name: UDP(3-)
initial amount: NaN
is: CHEBI:58223
notes: FORMULA: C9H11N2O12P2 CHARGE: -3 INCHI: InChI=1S/C9H14N2O12P2/c12-5-1-2-11(9(15)10-5)8-7(14)6(13)4(22-8)3-21-25(19,20)23-24(16,17)18/h1-2,4,6-8,13-14H,3H2,(H,19,20)(H,10,12,15)(H2,16,17,18)/p-3/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00025 EHMN_ABBREVIATION: C00015

metaR G3PD2m
is described by: ECO:0000304
reversible: false
product: MODEL1310110063#
reactant: MODEL1310110063#
name: glycerol-3-phosphate dehydrogenase (FAD), mitochondrial
is version of: http://identifiers.org/ec-code/1.1.5.3
modifier: MODEL1310110063#
fast: false
kinetic law: MODEL1310110063#
notes: GENE_ASSOCIATION: (2820.1) SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: 1.1.99.5 Confidence Level: 2 AUTHORS: PMID:11385633,PMID:8549872 NOTES:replaces old version which contains redundant metabolite (gly3p) NCD split compartmentation NJ
type: Reaction
is: SBO:0000185

metaM 2octdectecoa x
has only substance units: false
is: http://identifiers.org/pubchem.compound/5280355
type: Species
constant: false
name: 2,6,9,12-octadecatetraenoylcoa
is: SBO:0000247
boundary condition: false
notes: FORMULA: C39H58N7O17P3S CHARGE: -4
initial concentration: 1.0
initial amount: NaN

metaR C16OHc
kinetic law: MODEL1310110063#
product: MODEL1310110063#
reactant: MODEL1310110063#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: production of 3-hydroxyhexadecanoylcarnitinec
type: Reaction

metaR AG13T3g
notes: GENE_ASSOCIATION: (10331.1) or (11041.1) or (374907.2) or (10678.1) or (79369.1) or (374907.1) or (10678.2) or (93010.1) or (146712.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.149 Confidence Level: 4 AUTHORS: PMID:10747980,PMID:11042166,PMID:12061784,PMID:12512857,PMID:15560372,PMID:15620693,PMID:9405606 NOTES:NCD
reactant: MODEL1310110063#
modifier: MODEL1310110063#
name: N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase, Golgi apparatus
kinetic law: MODEL1310110063#
reversible: false
product: MODEL1310110063#
is version of: http://identifiers.org/ec-code/2.4.1.149
is described by: ECO:0000000
type: Reaction
is: SBO:0000176
fast: false

http://identifiers.org/biomodels.db/MODEL1310110063#_e88dae47_d69b_4270_8509_5625caa7ce58
has only substance units: false
is encoded by: hsa:56848
type: Species
is: Q9NRA0
name: SPHK2
constant: false
is: SBO:0000252
initial amount: NaN
initial concentration: NaN
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110063#_0be45229_9d9b_4150_b2b5_2dc1828d6135
initial amount: NaN
has only substance units: false
is encoded by: hsa:7841
boundary condition: true
initial concentration: NaN
type: Species
is: SBO:0000252
is: F5H6D0
name: MOGS
constant: false

metaM cdp m
initial amount: NaN
notes: FORMULA: C9H12N3O11P2 CHARGE: -3 INCHI: InChI=1S/C9H15N3O11P2/c10-5-1-2-12(9(15)11-5)8-7(14)6(13)4(22-8)3-21-25(19,20)23-24(16,17)18/h1-2,4,6-8,13-14H,3H2,(H,19,20)(H2,10,11,15)(H2,16,17,18)/p-3/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00110 EHMN_ABBREVIATION: C00112
boundary condition: false
is: HMDB01546
is: CHEBI:58069
type: Species
name: CDP(3-)
constant: false
is: SBO:0000247
initial concentration: 1.0
has only substance units: false

metaM octa e
constant: false
is: HMDB00482
type: Species
has only substance units: false
initial amount: NaN
name: octanoate (n-C8:0)
is: CHEBI:25646
boundary condition: false
initial concentration: 1.0
notes: FORMULA: C8H15O2 CHARGE: -1
is: C06423
is: SBO:0000247

metaM dolglcp U r
is: CHEBI:15812
initial concentration: 1.0
notes: FORMULA: C1085H1780O90P10 CHARGE: -10 INCHI: InChI=1S/C31H55O9P/c1-22(2)11-7-12-23(3)13-8-14-24(4)15-9-16-25(5)17-10-18-26(6)19-20-38-41(36,37)40-31-30(35)29(34)28(33)27(21-32)39-31/h11,13,15,17,26-35H,7-10,12,14,16,18-21H2,1-6H3,(H,36,37)/b23-13+,24-15+,25-17-/t26?,27-,28-,29+,30-,31+/m1/s1
initial amount: NaN
name: Dolichyl beta-D-glucosyl phosphate, human uterine homolog
is: SBO:0000247
constant: false
has only substance units: false
boundary condition: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110063#_66468edc_3961_4928_937e_8bee511a48d3
is: GO:0005737
is: SBO:0000290
constant: false
size: 1.0
spatial dimensions: 3.0
name: cytoplasm
type: Compartment

http://identifiers.org/biomodels.db/MODEL1310110063#_378f248b_f0cf_44f2_81e3_1d5142911e0e
constant: false
boundary condition: true
is encoded by: hsa:377841
type: Species
name: ENTPD8
is: SBO:0000252
initial amount: NaN
initial concentration: NaN
is: Q5MY95
has only substance units: false

metaR NACHEX2ly
reversible: false
product: MODEL1310110063#
reactant: MODEL1310110063#
is described by: ECO:0000000
kinetic law: MODEL1310110063#
is version of: http://identifiers.org/ec-code/3.2.1.52
name: beta-N-acetylhexosaminidase, lysosomal
fast: false
type: Reaction
notes: GENE_ASSOCIATION: (3073.1 and 3074.1) or (3073.1) or (3074.1) SUBSYSTEM: Chondroitin sulfate degradation EC Number: 3.2.1.52 Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12706724,PMID:8993162 NOTES:NCD
modifier: MODEL1310110063#
is: SBO:0000176

metaR r0295
fast: false
name: glycine synthase Nitrogen metabolism EC:2.1.2.10
is: SBO:0000176
reversible: false
type: Reaction
notes: GENE_ASSOCIATION: (6576.1) SUBSYSTEM: Glycine, serine, alanine and threonine metabolism EC Number: 2.1.2.10 Confidence Level: 0 AUTHORS: PMID:7916605 NOTES:
reactant: MODEL1310110063#
kinetic law: MODEL1310110063#
is described by: ECO:0000000
product: MODEL1310110063#
modifier: MODEL1310110063#

metaR RE3244R
is: SBO:0000176
product: MODEL1310110063#
fast: false
name: RE3244
is described by: ECO:0000000
reactant: MODEL1310110063#
type: Reaction
notes: GENE_ASSOCIATION: (64834.1) SUBSYSTEM: Fatty acid synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:10970790 NOTES:
modifier: MODEL1310110063#
reversible: true
kinetic law: MODEL1310110063#

http://identifiers.org/biomodels.db/MODEL1310110063#_9b43f571_724b_4af2_bd5d_a7167809a665
type: Species
constant: false
boundary condition: true
initial concentration: NaN
name: ATP5H:ATP5L:NSF:ATP5F1:ATP5G3:ATP5I:ATP5J:ATP5J2
has only substance units: false
initial amount: NaN
has part: Q6IB54
is encoded by: hsa:522
is: SBO:0000297

metaM leu L e
is: HMDB00687
initial concentration: 1.0
name: L-leucine
initial amount: NaN
is: CHEBI:15603
type: Species
boundary condition: false
constant: false
notes: FORMULA: C6H13NO2 CHARGE: 0 INCHI: InChI=1S/C6H13NO2/c1-4(2)3-5(7)6(8)9/h4-5H,3,7H2,1-2H3,(H,8,9)/t5-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00121 EHMN_ABBREVIATION: C00123
is: SBO:0000247
has only substance units: false

metaM asp L e
name: L-aspartate(1-)
has only substance units: false
initial amount: NaN
is: SBO:0000247
is: HMDB00191
type: Species
notes: FORMULA: C4H6NO4 CHARGE: -1 INCHI: InChI=1S/C4H7NO4/c5-2(4(8)9)1-3(6)7/h2H,1,5H2,(H,6,7)(H,8,9)/p-1/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00055
initial concentration: 1.0
constant: false
boundary condition: false
is: CHEBI:29991

http://identifiers.org/biomodels.db/MODEL1310110063#_b6534653_5aee_4099_8de5_79933c19c1fd
constant: false
initial concentration: NaN
is encoded by: hsa:3550
boundary condition: true
is: Q13123
initial amount: NaN
name: IK
is: SBO:0000252
type: Species
has only substance units: false

metaM camp c
name: 3',5'-cyclic AMP(1-)
notes: FORMULA: C10H11N5O6P CHARGE: -1 INCHI: InChI=1S/C10H12N5O6P/c11-8-5-9(13-2-12-8)15(3-14-5)10-6(16)7-4(20-10)1-19-22(17,18)21-7/h2-4,6-7,10,16H,1H2,(H,17,18)(H2,11,12,13)/p-1/t4-,6-,7-,10-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00434 EHMN_ABBREVIATION: C00575
is: SBO:0000247
has only substance units: false
initial amount: NaN
initial concentration: 1.0
boundary condition: false
type: Species
constant: false
is: CHEBI:58165
is: HMDB00058

metaM 2dp6mep m
initial concentration: 1.0
is: CHEBI:50774
boundary condition: false
has only substance units: false
type: Species
name: 2-Decaprenyl-6-methoxyphenol
initial amount: NaN
notes: FORMULA: C57H88O2 CHARGE: 0 INCHI: InChI=1S/C57H88O2/c1-45(2)23-13-24-46(3)25-14-26-47(4)27-15-28-48(5)29-16-30-49(6)31-17-32-50(7)33-18-34-51(8)35-19-36-52(9)37-20-38-53(10)39-21-40-54(11)43-44-55-41-22-42-56(59-12)57(55)58/h22-23,25,27,29,31,33,35,37,39,41-43,58H,13-21,24,26,28,30,32,34,36,38,40,44H2,1-12H3/b46-25+,47-27+,48-29+,49-31+,50-33+,51-35+,52-37+,53-39+,54-43+
constant: false
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110063#_0c9a94d4_df8d_499e_8237_041f55adfae2
is encoded by: hsa:9551
constant: false
initial concentration: NaN
boundary condition: true
has only substance units: false
name: ATP5J2
is: SBO:0000252
type: Species
initial amount: NaN
is: Q6IBB3

metaR RE1836X
type: Reaction
product: MODEL1310110063#
kinetic law: MODEL1310110063#
name: RE1836
is: SBO:0000176
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/2.3.1.176
reactant: MODEL1310110063#
fast: false
modifier: MODEL1310110063#
reversible: true
notes: GENE_ASSOCIATION: (6342.1) SUBSYSTEM: Bile acid synthesis EC Number: 2.3.1.154 Confidence Level: 0 AUTHORS: PMID:10706581 NOTES:

metaR r2379
reversible: true
reactant: MODEL1310110063#
type: Reaction
kinetic law: MODEL1310110063#
fast: false
is: SBO:0000185
product: MODEL1310110063#
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:16919238,PMID:17173541,PMID:18406340,PMID:8132483 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110063#_f32e4704_cba9_45a5_b4d8_8bb856a76437
type: Species
is encoded by: hsa:1629
is: P11182
has only substance units: false
boundary condition: true
name: DBT
initial concentration: NaN
initial amount: NaN
is: SBO:0000252
constant: false

metaR LNLCCPT1
notes: GENE_ASSOCIATION: (1375.1) or (1375.3) or (1375.4) or (126129.1) or (1374.1) or (1375.2) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.21 Confidence Level: 4 AUTHORS: NOTES:NJ
fast: false
kinetic law: MODEL1310110063#
product: MODEL1310110063#
reversible: false
reactant: MODEL1310110063#
is described by: ECO:0000269
type: Reaction
modifier: MODEL1310110063#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.3.1.21
name: carnitine O-palmitoyltransferase

metaR C8CRNe
kinetic law: MODEL1310110063#
product: MODEL1310110063#
reactant: MODEL1310110063#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of octanoyl carnitine into the extra cellular space
type: Reaction

metaR EX tetdece1crn
kinetic law: MODEL1310110063#
reactant: MODEL1310110063#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for tetradecenoyl carnitine
type: Reaction

metaR r0580
reversible: true
fast: false
notes: GENE_ASSOCIATION: (AD000092.1) or (2639.1) SUBSYSTEM: CoA synthesis EC Number: 4.1.1.30 Confidence Level: 0 AUTHORS: PMID:13163064 NOTES:
kinetic law: MODEL1310110063#
reactant: MODEL1310110063#
product: MODEL1310110063#
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/1.3.99.7
is: SBO:0000176
modifier: MODEL1310110063#
name: N-((R)-Pantothenoyl)-L-cysteine carboxy-lyase Pantothenate and CoA biosynthesis EC:4.1.1.30
type: Reaction

metaM h2o n
type: Species
notes: FORMULA: H2O CHARGE: 0 INCHI: InChI=1S/H2O/h1H2 HEPATONET_1.0_ABBREVIATION: HC00011 EHMN_ABBREVIATION: C00001
initial concentration: 1.0
is: HMDB02111
boundary condition: false
has only substance units: false
name: water
is: CHEBI:15377
constant: false
is: SBO:0000247
initial amount: NaN

metaR C142ACBP
kinetic law: MODEL1310110063#
product: MODEL1310110063#
reactant: MODEL1310110063#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: transport of 3-hydroxytetradeca dienoyl coa from mitochondria into cytosol
type: Reaction

metaR DECDICRNe
kinetic law: MODEL1310110063#
product: MODEL1310110063#
reactant: MODEL1310110063#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: trnasport of decadienoyl carnitine into the extra cellular space
type: Reaction

metaR r2378
kinetic law: MODEL1310110063#
fast: false
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:16919238,PMID:17173541,PMID:18406340,PMID:8132483 NOTES:
is: SBO:0000185
reversible: true
product: MODEL1310110063#
type: Reaction
reactant: MODEL1310110063#
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2

metaR LNLCCPT2
is described by: ECO:0000000
name: carnitine transferase
reactant: MODEL1310110063#
fast: false
kinetic law: MODEL1310110063#
modifier: MODEL1310110063#
is version of: http://identifiers.org/ec-code/2.3.1.21
type: Reaction
product: MODEL1310110063#
is: SBO:0000176
notes: GENE_ASSOCIATION: (1376.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: NOTES:NJ
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110063#_7e6a0db9_907a_4239_86b0_c3ffb70185a6
constant: false
initial concentration: NaN
is: SBO:0000252
initial amount: NaN
name: PDE8A
boundary condition: true
has only substance units: false
type: Species
is encoded by: hsa:5151

http://identifiers.org/biomodels.db/MODEL1310110063#_dbf7e4c1_39a7_4cc5_b219_5dda2aff9b2e
is encoded by: hsa:25902
type: Species
has only substance units: false
initial concentration: NaN
constant: false
initial amount: NaN
is: SBO:0000252
name: MTHFD1L
is: B2RD24
boundary condition: true

metaR FAEL205
reversible: false
is described by: ECO:0000000
kinetic law: MODEL1310110063#
type: Reaction
product: MODEL1310110063#
is: SBO:0000176
fast: false
name: fatty-acyl-CoA elongation (n-C20:5CoA)
notes: GENE_ASSOCIATION: (6785.1) SUBSYSTEM: Fatty acid synthesis EC Number: 2.3.1.86 Confidence Level: 4 AUTHORS: PMID:11138005,PMID:15189125 NOTES:fatty acid elongation step NJ
modifier: MODEL1310110063#
reactant: MODEL1310110063#

metaR DOLGPP Uer
kinetic law: MODEL1310110063#
is: SBO:0000176
reversible: false
type: Reaction
reactant: MODEL1310110063#
notes: GENE_ASSOCIATION: SUBSYSTEM: N-glycan synthesis EC Number: 3.1.4.48 Confidence Level: 0 AUTHORS: PMID:12137737 NOTES:
name: Dolichyl-beta-D-glucosyl-phosphate dolichylphosphohydrolase (uterus)
product: MODEL1310110063#
fast: false
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110063#_d5f3a094_acb5_48d0_8edb_a7cab92361aa
boundary condition: true
constant: false
initial amount: NaN
name: GCDH
is: Q92947
initial concentration: NaN
is: SBO:0000252
has only substance units: false
type: Species
is encoded by: hsa:2639

metaM h2o m
constant: false
notes: FORMULA: H2O CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00011 EHMN_ABBREVIATION: C00001
is: SBO:0000247
initial amount: NaN
is: CHEBI:15377
type: Species
name: H2O
is: C00001
has only substance units: false
initial concentration: 1.0
is: HMDB02111
boundary condition: false

metaM focytC m
boundary condition: false
initial amount: NaN
constant: false
type: Species
notes: FORMULA: C42H54FeN8O6S2 CHARGE: 2 HEPATONET_1.0_ABBREVIATION: HC00124
is: SBO:0000247
is: CHEBI:16928
has only substance units: false
name: Ferrocytochrome C
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110063#_a757f4e6_1dfe_4dbc_aabd_422d36802ff0
initial amount: NaN
is: Q9NYW8
name: RBAK
boundary condition: true
constant: false
is: SBO:0000252
is encoded by: hsa:57786
has only substance units: false
initial concentration: NaN
type: Species

http://identifiers.org/biomodels.db/MODEL1310110063#_0724959a_e75f_4cd8_ae41_94e017e59365
boundary condition: true
is: SBO:0000252
type: Species
initial concentration: NaN
name: SDHB
initial amount: NaN
is: P21912
constant: false
has only substance units: false
is encoded by: hsa:6390

metaM udp r
notes: FORMULA: C9H11N2O12P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00025 EHMN_ABBREVIATION: C00015
is: HMDB00295
name: UDP
is: C00015
type: Species
has only substance units: false
initial amount: NaN
boundary condition: false
is: CHEBI:58223
constant: false
initial concentration: 1.0
is: SBO:0000247

metaR EX HC01610 LPAREN e RPAREN
kinetic law: MODEL1310110063#
reactant: MODEL1310110063#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of CoproporphyrinogenI
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110063#_aaf982f7_e905_429d_939b_655e80aeeb6f
has part: H0UI06
has part: P15954
has part: P14854
initial concentration: NaN
is encoded by: hsa:4512
is encoded by: hsa:341947
initial amount: NaN
is encoded by: hsa:1337
is encoded by: hsa:1351
has part: P00414
has only substance units: false
has part: Q7Z4L0
is encoded by: hsa:1327
has part: Q7GXY8
has part: P24311
is encoded by: hsa:1345
has part: Q7GXZ8
is: SBO:0000297
has part: P24310
type: Species
has part: Q02221
has part: Q53YB7
is encoded by: hsa:1347
is encoded by: hsa:1350
is encoded by: hsa:1329
is encoded by: hsa:170712
is encoded by: hsa:1340
name: COX6B2:COX4I1:COX5B:COX6A1:COX6A2:COX6B1:COX6C:COX7A1:COX7A2:COX7B:COX7C:COX8A:COX7B2:COX8C:COX1:COX2:COX3:COX4I2:COX7A2L:COX5A
has part: P13073
has part: Q6YFQ2
has part: Q6FGA0
is encoded by: hsa:9167
has part: Q8TF08
is encoded by: hsa:4514
has part: Q96KJ9
is encoded by: hsa:1339
is encoded by: hsa:1349
constant: false
has part: Q53XN1
has part: P20674
boundary condition: true
is encoded by: hsa:84701
is encoded by: hsa:125965
has part: P09669
is encoded by: hsa:4513
is encoded by: hsa:9377
has part: P12074
is encoded by: hsa:1346

metaR PPItm
reactant: MODEL1310110063#
product: MODEL1310110063#
is: SBO:0000185
is described by: ECO:0000134
name: diphopshate transporter, mitochondrial
reversible: true
type: Reaction
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 1 AUTHORS: added during gap-filling. NOTES:added during gap-filling.
kinetic law: MODEL1310110063#

metaR r0437
reversible: true
fast: false
modifier: MODEL1310110063#
type: Reaction
is described by: ECO:0000000
reactant: MODEL1310110063#
is version of: http://identifiers.org/ec-code/4.1.2.13
name: Palmitoyl-CoA:L-carnitine O-palmitoyltransferase Fatty acid metabolism EC:2.3.1.21
kinetic law: MODEL1310110063#
is: SBO:0000176
product: MODEL1310110063#
notes: GENE_ASSOCIATION: (AI469183.1) or (226.1) or (229.1) or (230.1) or (BC005314.1) or (BF195998.1) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.21 Confidence Level: 0 AUTHORS: PMID:1735445,PMID:1988962,PMID:2355017,PMID:6361812,PMID:7892212 NOTES:

metaM dmnoncrn c
notes: FORMULA: C18H37NO4 CHARGE: 0
boundary condition: false
name: 4,8-dimethylnonanoyl carnitine
type: Species
is: SBO:0000247
has only substance units: false
initial amount: NaN
constant: false
is: HMDB06202
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110063#_7efbc798_3ac5_4420_97f2_f81b60401af7
is encoded by: hsa:728441
is: SBO:0000252
constant: false
boundary condition: true
type: Species
initial concentration: NaN
name: GGT2
has only substance units: false
initial amount: NaN

metaM dcsptn1crn m
constant: false
has only substance units: false
initial concentration: 1.0
is: SBO:0000247
initial amount: NaN
boundary condition: false
is: HMDB06321
type: Species
name: docosa-4,7,10,13,16-pentaenoyl carnitine
notes: FORMULA: C29H47NO4 CHARGE: 0 INCHI: InChI=1/C29H47NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-24-29(33)34-27(25-28(31)32)26-30(2,3)4/h9-10,12-13,15-16,18-19,21-22,27H,5-8,11,14,17,20,23-26H2,1-4H3/b10-9+,13-12+,16-15+,19-18+,22-21+

http://identifiers.org/biomodels.db/MODEL1310110063#_43a893c0_b8ab_44ca_963d_76ee1f436312
type: Species
boundary condition: true
is: SBO:0000252
name: _AI769281_1_e
initial amount: NaN
constant: false
has only substance units: false
initial concentration: NaN
is encoded by: hsa:AI769281

http://identifiers.org/biomodels.db/MODEL1310110063#_82d95b9c_d52a_4d85_a121_e3f97d382a4d
is: O75387
is encoded by: hsa:8501
constant: false
name: SLC43A1
type: Species
boundary condition: true
initial amount: NaN
has only substance units: false
is: SBO:0000252
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110063#_6dac7bd5_333e_4f67_aae5_e94a3aa45df3
is: SBO:0000297
constant: false
has part: P24539
is encoded by: hsa:10476
has only substance units: false
initial concentration: NaN
type: Species
initial amount: NaN
name: ATP5H:ATP5L:NSF:ATP5F1:ATP5G3:ATP5I:ATP5J:ATP5J2
has part: O75947
is encoded by: hsa:518
is encoded by: hsa:522
boundary condition: true
has part: P18859
is encoded by: hsa:515

metaM h2o l
initial concentration: 1.0
initial amount: NaN
is: CHEBI:15377
name: water
notes: FORMULA: H2O CHARGE: 0 INCHI: InChI=1S/H2O/h1H2 HEPATONET_1.0_ABBREVIATION: HC00011 EHMN_ABBREVIATION: C00001
constant: false
is: SBO:0000247
has only substance units: false
boundary condition: false
type: Species
is: HMDB02111

metaM pan4p e
name: Pantetheine 4'-phosphate
notes: FORMULA: C11H21N2O7PS CHARGE: -2
type: Species
constant: false
is: CHEBI:47942
is: SBO:0000247
boundary condition: false
is: HMDB01416
is: C01134
initial concentration: 1.0
initial amount: NaN
has only substance units: false

metaR TDCRNe
kinetic law: MODEL1310110063#
product: MODEL1310110063#
reactant: MODEL1310110063#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of myristoyl carnitine into extra cellular space
type: Reaction

metaR ACACT1rm
reversible: true
modifier: MODEL1310110063#
is version of: http://identifiers.org/ec-code/4.2.1.17
fast: false
reactant: MODEL1310110063#
notes: GENE_ASSOCIATION: (3030.1) and (3032.1) or (38.1) SUBSYSTEM: Tryptophan metabolism EC Number: 2.3.1.9 Confidence Level: 0 AUTHORS: NOTES:TDV
type: Reaction
product: MODEL1310110063#
name: acetyl-CoA C-acetyltransferase, mitochondrial
is: SBO:0000176
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/2.3.1.9
is version of: http://identifiers.org/ec-code/2.3.1.16
kinetic law: MODEL1310110063#

http://identifiers.org/biomodels.db/MODEL1310110063#_aa5db1b8_a523_4a4e_82ed_f461773153bc
name: TXNRD1
initial concentration: NaN
is: SBO:0000252
has only substance units: false
is: Q16881
type: Species
initial amount: NaN
is encoded by: hsa:7296
constant: false
boundary condition: true

metaM utp n
is: SBO:0000247
initial amount: NaN
initial concentration: 1.0
constant: false
name: UTP(4-)
is: HMDB00285
boundary condition: false
is: CHEBI:46398
type: Species
notes: FORMULA: C9H11N2O15P3 CHARGE: -4 INCHI: InChI=1S/C9H15N2O15P3/c12-5-1-2-11(9(15)10-5)8-7(14)6(13)4(24-8)3-23-28(19,20)26-29(21,22)25-27(16,17)18/h1-2,4,6-8,13-14H,3H2,(H,19,20)(H,21,22)(H,10,12,15)(H2,16,17,18)/p-4/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00077 EHMN_ABBREVIATION: C00075
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110063#_8202759a_721f_4de2_9c6c_8deff3dd2677
initial concentration: NaN
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:29926
boundary condition: true
has only substance units: false
type: Species
constant: false
name: GMPPA

metaR PRFGS
notes: GENE_ASSOCIATION: (5198.1) SUBSYSTEM: Purine synthesis EC Number: Confidence Level: 4 AUTHORS: NOTES:
name: phosphoribosylformylglycinamidine synthase
product: MODEL1310110063#
fast: false
kinetic law: MODEL1310110063#
is version of: http://identifiers.org/ec-code/6.3.5.3
is: SBO:0000176
type: Reaction
reactant: MODEL1310110063#
is described by: ECO:0000269
reversible: false
modifier: MODEL1310110063#

metaM dece3coa m
is: SBO:0000247
initial concentration: 1.0
initial amount: NaN
notes: FORMULA: C31H48N7O17P3S CHARGE: -4
constant: false
name: 3-decenoylcoa
type: Species
boundary condition: false
is: http://identifiers.org/pubchem.compound/16019966
has only substance units: false

metaM hpyr c
is: HMDB01352
is: SBO:0000247
boundary condition: false
is: CHEBI:17180
type: Species
name: 3-hydroxypyruvate
has only substance units: false
constant: false
initial concentration: 1.0
notes: FORMULA: C3H3O4 CHARGE: -1 INCHI: InChI=1S/C3H4O4/c4-1-2(5)3(6)7/h4H,1H2,(H,6,7)/p-1 HEPATONET_1.0_ABBREVIATION: HC00163 EHMN_ABBREVIATION: C00168
initial amount: NaN

MODEL1310110063
reaction: metaR r0354
species: metaM gum e
reaction: metaR LDH L
species: metaM lpam m
species: metaM ha deg1 l
species: metaM meoh e
species: metaM dlnlcgcoa c
species: metaM 3tetd7ecoacrn e
species: metaM clpnd c
reaction: metaR CYTDtm
species: metaM acgam c
reaction: metaR r1620
species: metaM lpchol hs e
species: metaM CE5101 m
species: metaM kynate c
reaction: metaR CYSSERNaEx
species: metaM h l
species: metaM 6thf e
reaction: metaR C16DCc
reaction: metaR MCPST
reaction: metaR EX fmn LPAREN e RPAREN
reaction: metaR ACACT1r
species: metaM nadp x
species: metaM glx m
reaction: metaR EX dhf LPAREN e RPAREN
reaction: metaR S6TASE14ly
species: metaM xylt c
species: metaM dnad c
species: metaM Rtotal2coa c
species: metaM dtmp c
reaction: metaR r1557
species: metaM gluside hs r
reaction: metaR HBZOPT10m
reaction: metaR r0627
species: metaM spmd c
species: metaM 34dhoxmand m
reaction: metaR MTHFD2
reaction: metaR r2104
reaction: metaR OCTDECE1CRNe
reaction: metaR r0580
reaction: metaR ME2m
reaction: metaR TYMSFt
reaction: metaR ALAR
species: metaM 4abut m
reaction: metaR B3GALT3g
reaction: metaR PYRt2m
reaction: metaR S6T2g
reaction: metaR PROSTGF2t
species: metaM T4hcinnm m
reaction: metaR r1573
reaction: metaR HDECEACBP
reaction: metaR RTOTALt
reaction: metaR r0643
species: metaM drib e
reaction: metaR M16NTg
reaction: metaR LNELDCCRNt
reaction: metaR OCTDECCACT
reaction: metaR r2062
reaction: metaR NDPK9n
reaction: metaR LNLCt
reaction: metaR sink decdicoa LPAREN c RPAREN
reaction: metaR r2396
species: metaM n2m2nmasn e
species: metaM cs b l
species: metaM hs deg5 l
species: metaM nicrnt c
reaction: metaR EX HC00229 LPAREN e RPAREN
reaction: metaR r2095
species: metaM clpn hs c
species: metaM thym e
species: metaM crn r
species: metaM sgalside hs g
reaction: metaR EX hco3 LPAREN e RPAREN
species: metaM pydx5p c
species: metaM leuktrA4 e
reaction: metaR r1291
reaction: metaR r2538
species: metaM ksii core2 deg4 l
species: metaM g3p c
species: metaM hpdcacrn c

metaR CHOLATEt
type: Reaction
fast: false
is: SBO:0000185
reversible: true
product: MODEL1310110063#
modifier: MODEL1310110063#
notes: GENE_ASSOCIATION: (6579.1) or (10599.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12507753,PMID:9007731,PMID:9334206 NOTES:NJ
name: cholate transport via bicarbonate countertransport
reactant: MODEL1310110063#
kinetic law: MODEL1310110063#
is described by: ECO:0000269

http://identifiers.org/biomodels.db/MODEL1310110063#_d73ee9ef_a226_47d1_a2da_4162acada877
boundary condition: true
initial amount: NaN
is encoded by: hsa:28231
has only substance units: false
name: SLCO4A1
type: Species
constant: false
is: Q96BD0
is: SBO:0000252
initial concentration: NaN

metaR DHCHOLESTANATEtm
kinetic law: MODEL1310110063#
is: SBO:0000185
name: lipid, flip-flop intracellular transport
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: PMID:12840657 NOTES:cholesterol precursor, transport by "diffusion" -> actually beleived to be flip-flop mechanism (PMID: 12840657). NJ
product: MODEL1310110063#
reactant: MODEL1310110063#
type: Reaction
reversible: true
fast: false

metaR LYStm
fast: false
notes: GENE_ASSOCIATION: (83884.1) or (10166.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172 NOTES:TDV
reactant: MODEL1310110063#
modifier: MODEL1310110063#
is described by: ECO:0000269
type: Reaction
is: SBO:0000185
kinetic law: MODEL1310110063#
name: Lysine mitochondrial transport via ornithine carrier
product: MODEL1310110063#
reversible: true

metaR r0870
is version of: http://identifiers.org/ec-code/2.7.7.72
kinetic law: MODEL1310110063#
type: Reaction
reversible: true
is version of: http://identifiers.org/ec-code/3.6.4.13
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/3.1.3.4
is: SBO:0000185
name: Facilitated diffusion
notes: GENE_ASSOCIATION: (AA419122.1) or (AA576959.1) or (64077.1) or (8776.1) or (8898.1) or (9107.1) or (29085.1) or (8611.1) or (8613.1) or (8612.1) or (81537.1) or (130367.1) or (23517.1) or (51095.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14977409,PMID:17466261 NOTES:
modifier: MODEL1310110063#
product: MODEL1310110063#
fast: false
is version of: http://identifiers.org/ec-code/3.6.1.1
reactant: MODEL1310110063#

http://identifiers.org/biomodels.db/MODEL1310110063#_acde2d95_31ba_4aca_a45c_4e70e94d77dd
name: CHAT
initial concentration: NaN
type: Species
constant: false
is encoded by: hsa:1103
is: D3DX95
boundary condition: true
has only substance units: false
is: SBO:0000252
initial amount: NaN

metaM 4hglusa m
initial concentration: 1.0
is: CHEBI:27809
is: SBO:0000247
is: HMDB06556
notes: FORMULA: C5H9NO4 CHARGE: 0 INCHI: InChI=1S/C5H9NO4/c6-4(5(9)10)1-3(8)2-7/h2-4,8H,1,6H2,(H,9,10)/t3-,4+/m1/s1 EHMN_ABBREVIATION: C05938
has only substance units: false
boundary condition: false
constant: false
initial amount: NaN
name: L-4-hydroxyglutamic semialdehyde
type: Species

http://identifiers.org/biomodels.db/MODEL1310110063#_f0d26bdd_439b_49b9_bbf8_a935c6cf7ebd
type: Species
is: Q01968
initial amount: NaN
is: SBO:0000252
is encoded by: hsa:4952
has only substance units: false
initial concentration: NaN
boundary condition: true
constant: false
name: OCRL

metaR r0584
reactant: MODEL1310110063#
is version of: http://identifiers.org/ec-code/1.2.1.5
kinetic law: MODEL1310110063#
is described by: ECO:0000000
name: Deamino-NAD+ nucleotidohydrolase Nicotinate and nicotinamide metabolism EC:3.6.1.9
reversible: true
notes: GENE_ASSOCIATION: (220.1) or (218.1) or (221.1) or (222.1) or (U37519.1) SUBSYSTEM: NAD metabolism EC Number: 3.6.1.9 Confidence Level: 0 AUTHORS: PMID:11579996,PMID:11946484 NOTES:
is: SBO:0000176
type: Reaction
fast: false
modifier: MODEL1310110063#
product: MODEL1310110063#

metaR P4508B11r
reactant: MODEL1310110063#
is: SBO:0000176
is described by: ECO:0000269
name: sterol 12-alpha-hydroxylase
product: MODEL1310110063#
notes: GENE_ASSOCIATION: (1582.1) SUBSYSTEM: Bile acid synthesis EC Number: Confidence Level: 4 AUTHORS: NOTES:NJ - added, substrates by analogy to other xol hydroxylase reactions (NADH and NADPH can both be used)
modifier: MODEL1310110063#
kinetic law: MODEL1310110063#
reversible: false
fast: false
is version of: http://identifiers.org/ec-code/1.14.13.95
type: Reaction

metaR CYANt
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:assumed to be readily diffusible MM
is: SBO:0000185
type: Reaction
reactant: MODEL1310110063#
kinetic law: MODEL1310110063#
reversible: true
name: Cyanide transport via diffusion (extracellular to cytosol)
is described by: ECO:0000000
product: MODEL1310110063#
fast: false

metaR G6PDH2rer
is described by: ECO:0000269
name: glucose 6-phosphate dehydrogenase, endoplasmic reticulum
reversible: true
modifier: MODEL1310110063#
kinetic law: MODEL1310110063#
is: SBO:0000176
type: Reaction
notes: GENE_ASSOCIATION: (9563.1) SUBSYSTEM: Pentose phosphate pathway EC Number: 1.1.1.47 Confidence Level: 4 AUTHORS: PMID:10349511,PMID:12831846,PMID:2156506 NOTES:NCD
fast: false
reactant: MODEL1310110063#
is version of: http://identifiers.org/ec-code/1.1.1.47
product: MODEL1310110063#

metaR r1668
reactant: MODEL1310110063#
type: Reaction
modifier: MODEL1310110063#
kinetic law: MODEL1310110063#
is described by: ECO:0000000
is: SBO:0000185
product: MODEL1310110063#
fast: false
name: Y+LAT2 Utilized transport
reversible: true
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:

metaR EX retn LPAREN e RPAREN
kinetic law: MODEL1310110063#
reactant: MODEL1310110063#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Retinoate exchange
type: Reaction

metaR r1929
kinetic law: MODEL1310110063#
name: Y+LAT2 Utilized transport
reversible: false
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
modifier: MODEL1310110063#
reactant: MODEL1310110063#
fast: false
type: Reaction
is: SBO:0000185
product: MODEL1310110063#

metaR ALAASNNaEx
reversible: false
is described by: ECO:0000269
product: MODEL1310110063#
fast: false
modifier: MODEL1310110063#
notes: GENE_ASSOCIATION: (6510.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14530974 NOTES:SAB see Kanai and Hediger 2004 (2003), PMID 14530974
reactant: MODEL1310110063#
type: Reaction
name: L-alanine/L-asparagine Na-dependent exchange (Ala-L in)
kinetic law: MODEL1310110063#
is: SBO:0000185

metaR RAI2
fast: false
name: retinal isomerase (9-cis)
is described by: ECO:0000000
reversible: true
type: Reaction
reactant: MODEL1310110063#
product: MODEL1310110063#
is: SBO:0000176
kinetic law: MODEL1310110063#
notes: GENE_ASSOCIATION: SUBSYSTEM: Vitamin A metabolism EC Number: 5.2.1.3 Confidence Level: 2 AUTHORS: PMID:1503811 NOTES:IT

metaR EX pchol hs LPAREN e RPAREN
kinetic law: MODEL1310110063#
reactant: MODEL1310110063#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Phosphatidylcholine (homo sapiens) exchange
type: Reaction

metaR NAGA2ly
fast: false
product: MODEL1310110063#
kinetic law: MODEL1310110063#
type: Reaction
notes: GENE_ASSOCIATION: (4668.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.49 Confidence Level: 4 AUTHORS: PMID:2174888,PMID:2551294 NOTES:Alpha-galactosidase B NJ
reversible: false
name: N-acetylgalactosaminidase, alpha-
is described by: ECO:0000000
reactant: MODEL1310110063#
modifier: MODEL1310110063#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.2.1.49

metaM dpcoa e
name: Dephospho-CoA
is: HMDB01373
constant: false
is: SBO:0000247
boundary condition: false
initial amount: NaN
is: CHEBI:57328
is: C00882
has only substance units: false
type: Species
notes: FORMULA: C21H33N7O13P2S CHARGE: -2
initial concentration: 1.0

metaM ksii core2 pre10 g
notes: FORMULA: C81H130N6O64S2X CHARGE: -3
name: keratan sulfate II biosynthesis, precursor 10
initial amount: NaN
is: SBO:0000247
initial concentration: 1.0
boundary condition: false
has only substance units: false
is: CHEBI:28067
constant: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110063#_512cbcb2_2f48_40cc_a90e_ec582b14d189
is encoded by: hsa:3032
has only substance units: false
initial concentration: NaN
name: HADHB
boundary condition: true
is: SBO:0000252
type: Species
constant: false
initial amount: NaN
is: P55084

metaM dece3coa x
has only substance units: false
constant: false
initial concentration: 1.0
name: 3-decenoylcoa
type: Species
boundary condition: false
is: SBO:0000247
notes: FORMULA: C31H48N7O17P3S CHARGE: -4
is: http://identifiers.org/pubchem.compound/16019966
initial amount: NaN

metaR BHBt
fast: false
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:1408469,PMID:16380372 NOTES:IT, TDV
product: MODEL1310110063#
type: Reaction
name: (R)-3-Hydroxybutanoate transport via H+ symport
reactant: MODEL1310110063#
is: SBO:0000185
kinetic law: MODEL1310110063#
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110063#_6a572751_6b1a_431d_9ff0_fbe49d88884c
constant: false
type: Species
initial concentration: NaN
is encoded by: hsa:10606
is: SBO:0000252
initial amount: NaN
is: P22234
name: PAICS
boundary condition: true
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110063#_6f4e7791_4214_4337_b17e_8ac93a1c8391
constant: false
name: HADHA
initial concentration: NaN
type: Species
is encoded by: hsa:3030
initial amount: NaN
has only substance units: false
is: SBO:0000252
boundary condition: true
is: E9KL44

metaR r1667
name: Y+LAT2 Utilized transport
reversible: true
kinetic law: MODEL1310110063#
is: SBO:0000185
product: MODEL1310110063#
fast: false
type: Reaction
modifier: MODEL1310110063#
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reactant: MODEL1310110063#
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110063#_865df3ee_d78c_46bc_b343_4696f23a83c8
is: SBO:0000252
boundary condition: true
has only substance units: false
is: P17812
constant: false
name: CTPS1
initial concentration: NaN
type: Species
is encoded by: hsa:1503
initial amount: NaN

metaR PHCHGSm
kinetic law: MODEL1310110063#
fast: false
reversible: true
is: SBO:0000176
product: MODEL1310110063#
notes: GENE_ASSOCIATION: SUBSYSTEM: Arginine and Proline Metabolism EC Number: Confidence Level: 2 AUTHORS: PMID:12660328,PMID:15849464 NOTES:taken from KEGG map. No enzyme assigned, so assumed this is a non-enzymatic reaction. NCD
reactant: MODEL1310110063#
name: L-1-Pyrroline-3-hydroxy-5-carboxylate spontaneous conversion to L-4-Hydroxyglutamate semialdehyde, mitochondrial
type: Reaction
is described by: ECO:0000000

metaR RPI
kinetic law: MODEL1310110063#
product: MODEL1310110063#
is described by: ECO:0000000
type: Reaction
modifier: MODEL1310110063#
name: ribose-5-phosphate isomerase
reactant: MODEL1310110063#
reversible: true
fast: false
is version of: http://identifiers.org/ec-code/5.3.1.6
is: SBO:0000176
notes: GENE_ASSOCIATION: (22934.1) SUBSYSTEM: Pentose phosphate pathway EC Number: 5.3.1.6 Confidence Level: 0 AUTHORS: NOTES:SMP

metaR r2062
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.15
is: SBO:0000185
reactant: MODEL1310110063#
product: MODEL1310110063#
fast: false
type: Reaction
kinetic law: MODEL1310110063#
reversible: false
modifier: MODEL1310110063#

metaR RTOTALFATPc
kinetic law: MODEL1310110063#
product: MODEL1310110063#
reactant: MODEL1310110063#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: uptake of Rtotal by enterocytes
type: Reaction

metaM h2o x
is: HMDB02111
name: H2O
is: SBO:0000247
constant: false
has only substance units: false
initial concentration: 1.0
notes: FORMULA: H2O CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00011 EHMN_ABBREVIATION: C00001
type: Species
is: C00001
boundary condition: false
initial amount: NaN
is: CHEBI:15377

metaR GALASE12ly
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) or (5476.1) and (2720.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.23 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD
modifier: MODEL1310110063#
type: Reaction
reversible: false
is described by: ECO:0000000
name: beta-galactosidase, lysosomal
fast: false
product: MODEL1310110063#
kinetic law: MODEL1310110063#
is version of: http://identifiers.org/ec-code/3.2.1.18
is version of: http://identifiers.org/ec-code/3.2.1.23
reactant: MODEL1310110063#
is version of: http://identifiers.org/ec-code/3.4.16.5
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.1.6.4

metaR EX cspg b LPAREN e RPAREN
kinetic law: MODEL1310110063#
reactant: MODEL1310110063#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: chondroitin sulfate B / dermatan sulfate (IdoA2S-GalNAc4S) proteoglycan exchange
type: Reaction

metaR r1666
modifier: MODEL1310110063#
reactant: MODEL1310110063#
type: Reaction
kinetic law: MODEL1310110063#
product: MODEL1310110063#
name: Y+LAT2 Utilized transport
is described by: ECO:0000000
reversible: true
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
fast: false
is: SBO:0000185

metaR EX 2hb LPAREN e RPAREN
kinetic law: MODEL1310110063#
reactant: MODEL1310110063#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 2-Hydroxybutyrate exchange
type: Reaction

metaR r1397
fast: false
name: carnitine acetyltransferase EC:2.3.1.7
reversible: false
product: MODEL1310110063#
is described by: ECO:0000000
reactant: MODEL1310110063#
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.7 Confidence Level: 0 AUTHORS: PMID:12133002,PMID:4475632,PMID:5810070 NOTES:
type: Reaction
kinetic law: MODEL1310110063#
is: SBO:0000176

metaR r1396
reversible: false
type: Reaction
name: EC:2.3.1.21
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.21 Confidence Level: 0 AUTHORS: PMID:12133002,PMID:4475632,PMID:5810070 NOTES:
reactant: MODEL1310110063#
is described by: ECO:0000000
kinetic law: MODEL1310110063#
fast: false
is: SBO:0000176
product: MODEL1310110063#

metaR LEUt4
name: L-leucine transport in via sodium symport
modifier: MODEL1310110063#
kinetic law: MODEL1310110063#
is described by: ECO:0000269
reactant: MODEL1310110063#
reversible: false
fast: false
type: Reaction
is: SBO:0000185
notes: GENE_ASSOCIATION: (81539.1) or (84889.1) or (6520.1) or (6542.1) or (6541.1) or (11254.1) or (55089.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10391915,PMID:10891391,PMID:11325958,PMID:11342143,PMID:11414754,PMID:11591158,PMID:11891586,PMID:12049641,PMID:1348489,PMID:1376926,PMID:14770310,PMID:7534987,PMID:8954799 NOTES:SAB
product: MODEL1310110063#

metaR PGLer
type: Reaction
is described by: ECO:0000269
modifier: MODEL1310110063#
is version of: http://identifiers.org/ec-code/1.1.1.47
name: 6-phosphogluconolactonase, endoplasmic reticulum
is: SBO:0000176
reactant: MODEL1310110063#
reversible: false
notes: GENE_ASSOCIATION: (9563.1) SUBSYSTEM: Pentose phosphate pathway EC Number: 3.1.1.31 Confidence Level: 4 AUTHORS: PMID:10349511,PMID:12831846,PMID:2156506 NOTES:SMP Net reaction same as described in Lehringer 334 NCD
fast: false
kinetic law: MODEL1310110063#
product: MODEL1310110063#

metaM asp L m
name: L-aspartate(1-)
constant: false
initial amount: NaN
type: Species
is: HMDB00191
is: SBO:0000247
initial concentration: 1.0
notes: FORMULA: C4H6NO4 CHARGE: -1 INCHI: InChI=1S/C4H7NO4/c5-2(4(8)9)1-3(6)7/h2H,1,5H2,(H,6,7)(H,8,9)/p-1/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00055
boundary condition: false
has only substance units: false
is: CHEBI:29991

metaM dpcoa c
notes: FORMULA: C21H33N7O13P2S CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00575 EHMN_ABBREVIATION: C00882
is: HMDB01373
name: Dephospho-CoA
type: Species
initial amount: NaN
is: C00882
boundary condition: false
constant: false
initial concentration: 1.0
has only substance units: false
is: CHEBI:57328
is: SBO:0000247

metaR PRODt2r
type: Reaction
kinetic law: MODEL1310110063#
is described by: ECO:0000304
is: SBO:0000185
reactant: MODEL1310110063#
name: D-proline reversible transport via proton symport
modifier: MODEL1310110063#
reversible: true
fast: false
notes: GENE_ASSOCIATION: (206358.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11390972,PMID:11959859 NOTES:NCD SAB D form
product: MODEL1310110063#

http://identifiers.org/biomodels.db/MODEL1310110063#_f78ebd42_226f_4eeb_b66a_5f77fc26c2ac
is encoded by: hsa:2954
name: GSTZ1
type: Species
initial concentration: NaN
constant: false
has only substance units: false
initial amount: NaN
is: SBO:0000252
boundary condition: true

metaM hgentis c
type: Species
boundary condition: false
is: CHEBI:16169
name: homogentisate
is: HMDB00130
constant: false
initial concentration: 1.0
is: SBO:0000247
initial amount: NaN
notes: FORMULA: C8H7O4 CHARGE: -1 INCHI: InChI=1S/C8H8O4/c9-6-1-2-7(10)5(3-6)4-8(11)12/h1-3,9-10H,4H2,(H,11,12)/p-1 HEPATONET_1.0_ABBREVIATION: HC00423 EHMN_ABBREVIATION: C00544
has only substance units: false

metaR DOLMANP Uter
kinetic law: MODEL1310110063#
notes: GENE_ASSOCIATION: SUBSYSTEM: N-glycan synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:12137737 NOTES:
fast: false
reversible: false
is described by: ECO:0000000
name: dolichol-phosphate mannose flippase (uterus)
product: MODEL1310110063#
type: Reaction
is: SBO:0000185
reactant: MODEL1310110063#

metaR PHACCOAGLNAC
reversible: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Phenylalanine metabolism EC Number: 2.3.1.14 Confidence Level: 2 AUTHORS: NOTES:SAB
fast: false
is described by: ECO:0000000
is: SBO:0000176
type: Reaction
kinetic law: MODEL1310110063#
name: Phenylacetyl-CoA:L-glutamine alpha-N-phenylacetyltransferase
product: MODEL1310110063#
reactant: MODEL1310110063#

metaR r0587
name: 4-Nitrophenyl phosphate phosphohydrolase gamma-Hexachlorocyclohexane degradation EC:3.1.3.2 EC:3.1.3.41 EC:3.1.3.1
kinetic law: MODEL1310110063#
is described by: ECO:0000000
reversible: true
product: MODEL1310110063#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.2.1.5
reactant: MODEL1310110063#
type: Reaction
fast: false
modifier: MODEL1310110063#
notes: GENE_ASSOCIATION: (220.1) or (218.1) or (221.1) or (222.1) or (U37519.1) SUBSYSTEM: Unassigned EC Number: 3.1.3.41 Confidence Level: 0 AUTHORS: PMID:11797369,PMID:1730777,PMID:388794 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110063#_be8d4494_d354_4a67_b9f8_d78c8660b532
type: Species
is: SBO:0000252
boundary condition: true
initial amount: NaN
is encoded by: hsa:587
is: O15382
name: BCAT2
has only substance units: false
constant: false
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110063#_e37567fc_0072_4286_943a_9ac269ff7f79
constant: false
has only substance units: false
is: SBO:0000252
is encoded by: hsa:2544
boundary condition: true
type: Species
name: _2544_1_c
initial amount: NaN
initial concentration: NaN

metaR r1665
name: Y+LAT2 Utilized transport
is described by: ECO:0000000
reversible: true
kinetic law: MODEL1310110063#
product: MODEL1310110063#
modifier: MODEL1310110063#
fast: false
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is: SBO:0000185
type: Reaction
reactant: MODEL1310110063#

metaM gchola e
type: Species
initial concentration: 1.0
boundary condition: false
is: HMDB00138
has only substance units: false
is: SBO:0000247
constant: false
initial amount: NaN
notes: FORMULA: C26H43NO6 CHARGE: 0
name: glycocholate

metaM C04849 e
initial amount: NaN
name: (5Z,9E,14Z)-(8xi,11R,12S)-11,12-epoxy-8-hydroxyicosa-5,9,14-trienoate
is: CHEBI:57449
is: SBO:0000247
type: Species
boundary condition: false
initial concentration: 1.0
constant: false
has only substance units: false
notes: FORMULA: C20H31O4 CHARGE: -1 INCHI: InChI=1S/C20H32O4/c1-2-3-4-5-6-10-13-18-19(24-18)16-15-17(21)12-9-7-8-11-14-20(22)23/h6-7,9-10,15-19,21H,2-5,8,11-14H2,1H3,(H,22,23)/p-1/b9-7-,10-6-,16-15+/t17?,18-,19+/m0/s1 EHMN_ABBREVIATION: C04849

metaM dcsptn1crn c
name: docosa-4,7,10,13,16-pentaenoyl carnitine
type: Species
is: SBO:0000247
has only substance units: false
initial concentration: 1.0
boundary condition: false
initial amount: NaN
constant: false
is: HMDB06321
notes: FORMULA: C29H47NO4 CHARGE: 0 INCHI: InChI=1/C29H47NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-24-29(33)34-27(25-28(31)32)26-30(2,3)4/h9-10,12-13,15-16,18-19,21-22,27H,5-8,11,14,17,20,23-26H2,1-4H3/b10-9+,13-12+,16-15+,19-18+,22-21+

http://identifiers.org/biomodels.db/MODEL1310110063#_c1ac5487_67d9_4592_813b_97c62d831f89
name: NPR2
is: P20594
is encoded by: hsa:4882
type: Species
constant: false
is: SBO:0000252
initial concentration: NaN
has only substance units: false
initial amount: NaN
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110063#_6bd39547_49c8_4388_ad9e_06e183a527eb
is: Q9H999
constant: false
has only substance units: false
initial amount: NaN
name: PANK3
is encoded by: hsa:79646
boundary condition: true
initial concentration: NaN
type: Species
is: SBO:0000252

metaR C10DCc
kinetic law: MODEL1310110063#
product: MODEL1310110063#
reactant: MODEL1310110063#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: production of sebacoylcarnitine
type: Reaction

metaR EX mal L LPAREN e RPAREN
kinetic law: MODEL1310110063#
reactant: MODEL1310110063#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: Exchange of L-malate
type: Reaction

metaM 3mb2coa m
boundary condition: false
is: HMDB01493
is: CHEBI:57344
type: Species
initial concentration: 1.0
constant: false
is: SBO:0000247
notes: FORMULA: C26H38N7O17P3S CHARGE: -4 INCHI: InChI=1S/C26H42N7O17P3S/c1-14(2)9-17(35)54-8-7-28-16(34)5-6-29-24(38)21(37)26(3,4)11-47-53(44,45)50-52(42,43)46-10-15-20(49-51(39,40)41)19(36)25(48-15)33-13-32-18-22(27)30-12-31-23(18)33/h9,12-13,15,19-21,25,36-37H,5-8,10-11H2,1-4H3,(H,28,34)(H,29,38)(H,42,43)(H,44,45)(H2,27,30,31)(H2,39,40,41)/p-4/t15-,19-,20-,21+,25-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01047 EHMN_ABBREVIATION: C03069
has only substance units: false
initial amount: NaN
name: 3-methylbut-2-enoyl-CoA(4-)

http://identifiers.org/biomodels.db/MODEL1310110063#_16507725_5d75_4b1a_a58e_f611b6a1985d
is: O95470
initial concentration: NaN
type: Species
has only substance units: false
name: SGPL1
constant: false
boundary condition: true
initial amount: NaN
is: SBO:0000252
is encoded by: hsa:8879

http://identifiers.org/biomodels.db/MODEL1310110063#_4dffe7f8_f185_45c1_a2b6_a4010ac521d2
initial amount: NaN
boundary condition: true
type: Species
is: Q9H477
is: SBO:0000252
has only substance units: false
name: RBKS
constant: false
initial concentration: NaN
is encoded by: hsa:64080

metaR r1664
is: SBO:0000185
reactant: MODEL1310110063#
name: Y+LAT2 Utilized transport
reversible: true
type: Reaction
fast: false
kinetic law: MODEL1310110063#
modifier: MODEL1310110063#
is described by: ECO:0000000
product: MODEL1310110063#
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:

metaM octa c
boundary condition: false
notes: FORMULA: C8H15O2 CHARGE: -1
constant: false
initial concentration: 1.0
has only substance units: false
type: Species
is: C06423
is: CHEBI:25646
is: HMDB00482
name: octanoate (n-C8:0)
initial amount: NaN
is: SBO:0000247

metaR HSD17B4x
reversible: false
kinetic law: MODEL1310110063#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/4.2.1.107
fast: false
product: MODEL1310110063#
reactant: MODEL1310110063#
name: hydroxysteroid (17-beta) dehydrogenase 4
modifier: MODEL1310110063#
notes: GENE_ASSOCIATION: (3295.1) SUBSYSTEM: Bile acid synthesis EC Number: Confidence Level: 4 AUTHORS: NOTES:see Russell bile acid synthesis review paper in human recon citation db adamanski et al Steroids (1997) 62:159 notes cofactor NADP/NADPH use
is described by: ECO:0000269
type: Reaction

metaR PHEt4
modifier: MODEL1310110063#
reactant: MODEL1310110063#
notes: GENE_ASSOCIATION: (54407.1) or (84889.1) or (11254.1) or (6542.1) or (81539.1) or (6541.1) or (55089.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10747860,PMID:10891391,PMID:10930503,PMID:11325958,PMID:11342143,PMID:11414754,PMID:11591158,PMID:11891586,PMID:12049641,PMID:1348489,PMID:14770310,PMID:7534987,PMID:8954799 NOTES:SAB
name: L-phenylalanine transport in via sodium symport
kinetic law: MODEL1310110063#
product: MODEL1310110063#
fast: false
is: SBO:0000185
reversible: false
is described by: ECO:0000269
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110063#_766b03d4_8b1c_4c03_bfa1_c3ce29be0424
type: Species
initial concentration: NaN
name: UCK1
is: SBO:0000252
constant: false
boundary condition: true
is: Q5JT09
initial amount: NaN
is encoded by: hsa:83549
has only substance units: false

metaM CE0849 m
type: Species
boundary condition: false
is: SBO:0000247
constant: false
initial amount: NaN
notes: FORMULA: C37H58N7O17P3S CHARGE: -4 INCHI: InChI=1/C37H62N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-28(46)65-21-20-39-27(45)18-19-40-35(49)32(48)37(2,3)23-58-64(55,56)61-63(53,54)57-22-26-31(60-62(50,51)52)30(47)36(59-26)44-25-43-29-33(38)41-24-42-34(29)44/h8-9,11-12,24-26,30-32,36,47-48H,4-7,10,13-23H2,1-3H3,(H,39,45)(H,40,49)(H,53,54)(H,55,56)(H2,38,41,42)(H2,50,51,52)/p-4/b9-8-,12-11-/t26-,30+,31+,32u,36-/m0/s1 EHMN_ABBREVIATION: CE0849
is: CHEBI:57795
has only substance units: false
initial concentration: 1.0
name: cis,cis-palmito-7,10-dienoyl-CoA

metaR FAOXC10C10OHm
kinetic law: MODEL1310110063#
product: MODEL1310110063#
reactant: MODEL1310110063#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C10-->OHC10)m
type: Reaction

metaR HDDACBP
kinetic law: MODEL1310110063#
product: MODEL1310110063#
reactant: MODEL1310110063#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: transport of (S)-3-Hydroxydodecanoyl-CoA from mitochondria into the cytosol
type: Reaction

metaM ksi pre30 g
type: Species
initial concentration: 1.0
name: keratan sulfate I biosynthesis, precursor 30
has only substance units: false
boundary condition: false
is: CHEBI:58053
initial amount: NaN
is: C00130
is: SBO:0000247
constant: false
notes: FORMULA: C219H350N15O184S9X CHARGE: -10
is: HMDB00175

metaM maltttr e
initial amount: NaN
is: HMDB01296
name: Maltotetraose
boundary condition: false
constant: false
is: http://identifiers.org/pubchem.compound/5141
type: Species
is: C02052
is: SBO:0000247
initial concentration: 1.0
notes: FORMULA: C24H42O21 CHARGE: 0 INCHI: InChI=1/C24H42O21/c25-1-5-9(29)10(30)15(35)22(40-5)44-19-7(3-27)42-24(17(37)12(19)32)45-20-8(4-28)41-23(16(36)13(20)33)43-18-6(2-26)39-21(38)14(34)11(18)31/h5-38H,1-4H2/t5-,6-,7-,8-,9-,10+,11-,12-,13-,14-,15-,16-,17-,18-,19-,20-,21u,22-,23-,24-/m1/s1 EHMN_ABBREVIATION: C02052
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110063#_ae4c4303_f4c5_4940_8895_f613e8d6f929
is: Q53H96
is: SBO:0000252
type: Species
boundary condition: true
constant: false
has only substance units: false
name: PYCRL
is encoded by: hsa:65263
initial amount: NaN
initial concentration: NaN

metaR ADCim
type: Reaction
product: MODEL1310110063#
reversible: false
is: SBO:0000176
reactant: MODEL1310110063#
notes: GENE_ASSOCIATION: SUBSYSTEM: Propanoate metabolism EC Number: 4.1.1.4 Confidence Level: 2 AUTHORS: NOTES:TDV (Voet & Voet pg 581) Non-enzymatic decarboxylation; spontaneous reaction added "m" suffix - NCD
name: Acetoacetate decarboxylation (irreversible), mitochondrial
fast: false
is described by: ECO:0000000
kinetic law: MODEL1310110063#

metaM gchola c
initial amount: NaN
type: Species
initial concentration: 1.0
has only substance units: false
boundary condition: false
is: HMDB00138
is: SBO:0000247
notes: FORMULA: C26H43NO6 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00863 EHMN_ABBREVIATION: C01921
is: CHEBI:58235
name: glycocholate
constant: false

http://identifiers.org/biomodels.db/MODEL1310110063#_ff9b7aa6_20df_49a2_b2d6_0295e6239fbe
has only substance units: false
is: SBO:0000252
initial amount: NaN
boundary condition: true
initial concentration: NaN
name: MAOB
is: P27338
constant: false
type: Species
is encoded by: hsa:4129

metaR EX duri LPAREN e RPAREN
kinetic law: MODEL1310110063#
reactant: MODEL1310110063#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for Deoxyuridine
type: Reaction

metaM CE5160 r
boundary condition: false
initial concentration: 1.0
is: SBO:0000247
initial amount: NaN
has only substance units: false
is: CHEBI:57923
notes: FORMULA: C39H62N7O18P3S CHARGE: -4 INCHI: InChI=1/C39H66N7O18P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-27(47)22-30(49)68-21-20-41-29(48)18-19-42-37(52)34(51)39(2,3)24-61-67(58,59)64-66(56,57)60-23-28-33(63-65(53,54)55)32(50)38(62-28)46-26-45-31-35(40)43-25-44-36(31)46/h11-12,25-26,28,32-34,38,50-51H,4-10,13-24H2,1-3H3,(H,41,48)(H,42,52)(H,56,57)(H,58,59)(H2,40,43,44)(H2,53,54,55)/p-4/b12-11-/t28-,32+,33+,34u,38-/m0/s1 EHMN_ABBREVIATION: CE5160
name: 3-oxo-cis-9-octadecenoyl-CoA
constant: false
type: Species

metaR FAOXC181C161m
kinetic law: MODEL1310110063#
product: MODEL1310110063#
reactant: MODEL1310110063#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C18:1-->C16:1)m
type: Reaction

metaM 2ddecdicoa m
is: SBO:0000247
has only substance units: false
initial concentration: 1.0
notes: FORMULA: C33H50N7O17P3S CHARGE: -4
is: C05279
is: HMDB11123
initial amount: NaN
name: 2,6-dodecadienoylcoa
type: Species
boundary condition: false
constant: false

metaR RPE
is: SBO:0000176
reversible: true
product: MODEL1310110063#
is version of: http://identifiers.org/ec-code/5.1.3.1
is described by: ECO:0000000
fast: false
name: ribulose 5-phosphate 3-epimerase
type: Reaction
notes: GENE_ASSOCIATION: (6120.1) or (6120.2) SUBSYSTEM: Pentose phosphate pathway EC Number: 5.1.3.1 Confidence Level: 0 AUTHORS: NOTES:SMP
reactant: MODEL1310110063#
modifier: MODEL1310110063#
kinetic law: MODEL1310110063#

http://identifiers.org/biomodels.db/MODEL1310110063#_6cc26254_fe7a_482f_b2f4_d18770ed91d5
is encoded by: hsa:D87002
name: _D87002_1_e
boundary condition: true
has only substance units: false
initial concentration: NaN
initial amount: NaN
constant: false
is: SBO:0000252
type: Species

metaR HOXG
notes: GENE_ASSOCIATION: (3162.1) or (3163.1) SUBSYSTEM: Heme degradation EC Number: 1.14.99.3 Confidence Level: 0 AUTHORS: PMID:16356137 NOTES:TDV (4/28/2004) There are conflicting data on how many moles of NADPH consumed per mole of Biliverdine (Tenhunen 1969, Ryter, 2000). Heme oxygenase is a well known enzyme
type: Reaction
is described by: ECO:0000134
kinetic law: MODEL1310110063#
modifier: MODEL1310110063#
reactant: MODEL1310110063#
name: Heme oxygenase 1
is version of: http://identifiers.org/ec-code/1.14.99.3
is: SBO:0000176
fast: false
product: MODEL1310110063#
reversible: false

metaR DM btn
kinetic law: MODEL1310110063#
reactant: MODEL1310110063#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: Demand for biotin
type: Reaction

metaR r1662
reversible: true
is: SBO:0000185
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reactant: MODEL1310110063#
kinetic law: MODEL1310110063#
type: Reaction
fast: false
modifier: MODEL1310110063#
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
product: MODEL1310110063#
is described by: ECO:0000000

metaR ABUTD
is described by: ECO:0000269
kinetic law: MODEL1310110063#
name: Aminobutyraldehyde dehydrogenase
notes: GENE_ASSOCIATION: (223.1) SUBSYSTEM: beta-Alanine metabolism EC Number: 1.2.1.19 Confidence Level: 4 AUTHORS: PMID:8786138 NOTES:JLR
modifier: MODEL1310110063#
is: SBO:0000176
fast: false
reversible: false
is version of: http://identifiers.org/ec-code/1.2.1.3
type: Reaction
reactant: MODEL1310110063#
product: MODEL1310110063#

http://identifiers.org/biomodels.db/MODEL1310110063#_554ba5ba_c015_4de3_8ca3_17ac3bf37094
name: MANBA
is encoded by: hsa:4126
is: O00462
type: Species
boundary condition: true
has only substance units: false
constant: false
initial concentration: NaN
initial amount: NaN
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110063#_bfe6767f_6e45_4a2b_8d2f_bcde513a077b
boundary condition: true
is: P11926
constant: false
is encoded by: hsa:4953
type: Species
initial concentration: NaN
initial amount: NaN
is: SBO:0000252
has only substance units: false
name: ODC1

metaR NTD2e
type: Reaction
product: MODEL1310110063#
reactant: MODEL1310110063#
reversible: false
is: SBO:0000176
modifier: MODEL1310110063#
notes: GENE_ASSOCIATION: (4907.1) SUBSYSTEM: Nucleotide interconversion EC Number: 3.1.3.5 Confidence Level: 2 AUTHORS: PMID:2840110 NOTES:Wide specificity for 5'-nucleotides Also see EC 3.1.3.31
is described by: ECO:0000134
fast: false
is version of: http://identifiers.org/ec-code/3.1.3.5
kinetic law: MODEL1310110063#
name: 5'-nucleotidase (UMP), extracellular

metaM 7thf e
is: SBO:0000247
initial concentration: 1.0
has only substance units: false
name: heptaglutamyl folate (THF)
boundary condition: false
is: HMDB06559
notes: FORMULA: C49H57N13O24 CHARGE: -8
constant: false
type: Species
initial amount: NaN

metaR NH4tp
type: Reaction
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD
is: SBO:0000185
reversible: true
name: ammonia peroxisomal transport
product: MODEL1310110063#
kinetic law: MODEL1310110063#
reactant: MODEL1310110063#
is described by: ECO:0000000

metaM aacoa x
initial amount: NaN
name: acetoacetyl-CoA(4-)
has only substance units: false
initial concentration: 1.0
is: HMDB01484
notes: FORMULA: C25H36N7O18P3S CHARGE: -4 INCHI: InChI=1S/C25H40N7O18P3S/c1-13(33)8-16(35)54-7-6-27-15(34)4-5-28-23(38)20(37)25(2,3)10-47-53(44,45)50-52(42,43)46-9-14-19(49-51(39,40)41)18(36)24(48-14)32-12-31-17-21(26)29-11-30-22(17)32/h11-12,14,18-20,24,36-37H,4-10H2,1-3H3,(H,27,34)(H,28,38)(H,42,43)(H,44,45)(H2,26,29,30)(H2,39,40,41)/p-4/t14-,18-,19-,20+,24-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00282 EHMN_ABBREVIATION: C00332
type: Species
is: CHEBI:57286
constant: false
boundary condition: false
is: SBO:0000247

metaR r1661
reactant: MODEL1310110063#
kinetic law: MODEL1310110063#
is described by: ECO:0000000
fast: false
reversible: true
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
product: MODEL1310110063#
type: Reaction
modifier: MODEL1310110063#
is: SBO:0000185
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1

metaR FAOXC183C163Gm
kinetic law: MODEL1310110063#
product: MODEL1310110063#
reactant: MODEL1310110063#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C18:3-->C16:3)gm
type: Reaction

metaR GLNtm
is: SBO:0000185
kinetic law: MODEL1310110063#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: NOTES:TV (6/7/2005) Study in rat liver (Soboll, 1991)
name: L-glutamine transport via electroneutral transporter
reversible: false
fast: false
is described by: ECO:0000000
product: MODEL1310110063#
reactant: MODEL1310110063#

metaM pan4p m
initial concentration: 1.0
is: CHEBI:47942
has only substance units: false
is: SBO:0000247
constant: false
type: Species
boundary condition: false
initial amount: NaN
name: pantetheine 4'-phosphate(2-)
notes: FORMULA: C11H21N2O7PS CHARGE: -2 INCHI: InChI=1S/C11H23N2O7PS/c1-11(2,7-20-21(17,18)19)9(15)10(16)13-4-3-8(14)12-5-6-22/h9,15,22H,3-7H2,1-2H3,(H,12,14)(H,13,16)(H2,17,18,19)/p-2 HEPATONET_1.0_ABBREVIATION: HC00681 EHMN_ABBREVIATION: C01134
is: HMDB01416

http://identifiers.org/biomodels.db/MODEL1310110063#_20f713c4_acd8_451e_83a3_bdbd9c1258d4
is: SBO:0000252
initial concentration: NaN
is: Q8TCD5
is encoded by: hsa:30833
constant: false
boundary condition: true
name: NT5C
type: Species
has only substance units: false
initial amount: NaN

metaM xoldioloneh c
name: 7alpha,12alpha-dihydroxy-5beta-cholestan-3-one
is: HMDB06887
has only substance units: false
is: SBO:0000247
boundary condition: false
is: CHEBI:2288
type: Species
initial amount: NaN
notes: FORMULA: C27H46O3 CHARGE: 0 INCHI: InChI=1S/C27H46O3/c1-16(2)7-6-8-17(3)20-9-10-21-25-22(15-24(30)27(20,21)5)26(4)12-11-19(28)13-18(26)14-23(25)29/h16-18,20-25,29-30H,6-15H2,1-5H3/t17-,18+,20-,21+,22+,23-,24+,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01462 EHMN_ABBREVIATION: C05453
initial concentration: 1.0
constant: false

metaR RAI1
type: Reaction
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Vitamin A metabolism EC Number: 5.2.1.3 Confidence Level: 2 AUTHORS: PMID:1503811 NOTES:IT
kinetic law: MODEL1310110063#
name: retinal isomerase (11-cis)
reversible: true
reactant: MODEL1310110063#
fast: false
is described by: ECO:0000000
product: MODEL1310110063#

metaR EX dad 2 LPAREN e RPAREN
kinetic law: MODEL1310110063#
reactant: MODEL1310110063#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for 2-deoxyadenosine
type: Reaction

metaR HISCAT1
kinetic law: MODEL1310110063#
product: MODEL1310110063#
reactant: MODEL1310110063#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: Transport of L-Histidine by y+ transporter
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110063#_70345335_57d4_499c_9a0e_d61a48364ecc
has only substance units: false
initial concentration: NaN
constant: false
boundary condition: true
type: Species
initial amount: NaN
is: SBO:0000252
is encoded by: hsa:BE966236
name: _BE966236_1_m

metaR EX dha LPAREN e RPAREN
kinetic law: MODEL1310110063#
reactant: MODEL1310110063#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of glycerone
type: Reaction

metaM 3octdeccrn e
notes: FORMULA: C25H49NO5 CHARGE: 0
constant: false
initial concentration: 1.0
type: Species
is: SBO:0000247
initial amount: NaN
is: HMDB13336
boundary condition: false
has only substance units: false
name: 3-hydroxyoctadecanoyl carnitine

http://identifiers.org/biomodels.db/MODEL1310110063#_60251ce9_ac5a_4782_8a9a_10f3f4a76b33
constant: false
initial amount: NaN
boundary condition: true
initial concentration: NaN
has only substance units: false
name: AK4
is encoded by: hsa:205
type: Species
is: SBO:0000252

metaR VLCSp
reversible: false
product: MODEL1310110063#
name: Very-long-chain-fatty-acid-CoA ligase
modifier: MODEL1310110063#
type: Reaction
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/6.2.1.3
is: SBO:0000176
kinetic law: MODEL1310110063#
fast: false
notes: GENE_ASSOCIATION: (11001.1) SUBSYSTEM: Bile acid synthesis EC Number: 6.2.1.7 Confidence Level: 4 AUTHORS: NOTES:from uniprot and lit - see human recon lit refs divalent cation requirement - unclear which one, reaction inhibited in the presence of EDTA (may just be MgATP or MgATP) - see Kelley and Vessey Biochimica et Biophysica Acta (1994) 1209: 51-55 temporarily will have H+ balance reaction NJ
reactant: MODEL1310110063#

metaR FAOXC101C102x
kinetic law: MODEL1310110063#
product: MODEL1310110063#
reactant: MODEL1310110063#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C10:1-->C10:2)x
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110063#_d0291dbf_656c_4e96_8d36_00c5c1069803
constant: false
has only substance units: false
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:AI469183
is: SBO:0000252
name: _AI469183_1_x
boundary condition: true
type: Species

metaM btcoa x
notes: FORMULA: C25H38N7O17P3S CHARGE: -4
is: C00136
boundary condition: false
name: Butanoyl-CoA
type: Species
has only substance units: false
is: HMDB01088
constant: false
initial concentration: 1.0
is: SBO:0000247
initial amount: NaN

metaM itaccoa m
constant: false
notes: FORMULA: C26H35N7O19P3S CHARGE: -5 INCHI: InChI=1S/C26H40N7O19P3S/c1-13(25(39)40)8-16(35)56-7-6-28-15(34)4-5-29-23(38)20(37)26(2,3)10-49-55(46,47)52-54(44,45)48-9-14-19(51-53(41,42)43)18(36)24(50-14)33-12-32-17-21(27)30-11-31-22(17)33/h11-12,14,18-20,24,36-37H,1,4-10H2,2-3H3,(H,28,34)(H,29,38)(H,39,40)(H,44,45)(H,46,47)(H2,27,30,31)(H2,41,42,43)/p-5/t14-,18-,19-,20+,24-/m1/s1 EHMN_ABBREVIATION: C00531
initial amount: NaN
type: Species
boundary condition: false
is: HMDB03377
name: itaconyl-CoA(5-)
is: CHEBI:57381
initial concentration: 1.0
is: SBO:0000247
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110063#_9a9aeba5_88a0_47bb_8173_a7cbd3135919
initial amount: NaN
is: P00558
name: PGK1
type: Species
initial concentration: NaN
boundary condition: true
is encoded by: hsa:5230
is: SBO:0000252
has only substance units: false
constant: false

http://identifiers.org/biomodels.db/MODEL1310110063#_ac3bfae1_3a7e_4430_a822_7193d2ffb46b
is: SBO:0000252
has only substance units: false
initial concentration: NaN
boundary condition: true
type: Species
name: VNN3
initial amount: NaN
constant: false
is encoded by: hsa:55350

metaR LYStiDF
modifier: MODEL1310110063#
name: L-lysine transport via diffusion (extracellular to cytosol)
is: SBO:0000185
kinetic law: MODEL1310110063#
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (6541.1) or (6542.1) or (55089.1) or (84889.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:11342143,PMID:11414754,PMID:11591158,PMID:11891586,PMID:12049641,PMID:1348489,PMID:14770310,PMID:7534987,PMID:8954799 NOTES:SAB
fast: false
reversible: false
reactant: MODEL1310110063#
product: MODEL1310110063#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110063#_206021ee_8ede_4aed_a896_97ecce07a8b0
initial concentration: NaN
boundary condition: true
constant: false
name: NDUFB9
type: Species
has only substance units: false
initial amount: NaN
is: Q9Y6M9
is: SBO:0000252
is encoded by: hsa:4715

metaR FAOXC160
reversible: false
is version of: http://identifiers.org/ec-code/1.3.8.1
is: SBO:0000176
type: Reaction
reactant: MODEL1310110063#
kinetic law: MODEL1310110063#
is version of: http://identifiers.org/ec-code/1.3.99.3
notes: GENE_ASSOCIATION: (34.1) or (35.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.99.3 Confidence Level: 4 AUTHORS: PMID:2565344,PMID:3035565 NOTES:TV Other enzymes: 1.3.3.6, 4.2.1.74, 4.2.1.17, 1.1.1.35, 1.1.1.211
product: MODEL1310110063#
name: Beta oxidation of long chain fatty acid
fast: false
modifier: MODEL1310110063#
is described by: ECO:0000269

metaM C02528 c
is: CHEBI:36234
initial amount: NaN
initial concentration: 1.0
has only substance units: false
name: chenodeoxycholate
constant: false
is: HMDB00518
type: Species
boundary condition: false
notes: FORMULA: C24H39O4 CHARGE: -1 INCHI: InChI=1S/C24H40O4/c1-14(4-7-21(27)28)17-5-6-18-22-19(9-11-24(17,18)3)23(2)10-8-16(25)12-15(23)13-20(22)26/h14-20,22,25-26H,4-13H2,1-3H3,(H,27,28)/p-1/t14-,15+,16-,17-,18+,19+,20-,22+,23+,24-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00958 EHMN_ABBREVIATION: C02528
is: SBO:0000247

metaM ttdca c
constant: false
initial concentration: 1.0
has only substance units: false
type: Species
is: HMDB00806
is: SBO:0000247
boundary condition: false
notes: FORMULA: C14H27O2 CHARGE: -1 INCHI: InChI=1S/C14H28O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14(15)16/h2-13H2,1H3,(H,15,16)/p-1 EHMN_ABBREVIATION: C06424
is: CHEBI:30807
name: myristate
initial amount: NaN

metaR r1933
is: SBO:0000185
type: Reaction
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reversible: false
fast: false
modifier: MODEL1310110063#
product: MODEL1310110063#
kinetic law: MODEL1310110063#
is described by: ECO:0000000
name: Y+LAT2 Utilized transport
reactant: MODEL1310110063#

metaR EX bhb LPAREN e RPAREN
kinetic law: MODEL1310110063#
reactant: MODEL1310110063#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: (R)-3-Hydroxybutanoate transport via H+ symport
type: Reaction

metaM 3mop m
constant: false
is: SBO:0000247
notes: FORMULA: C6H9O3 CHARGE: -1 INCHI: InChI=1S/C6H10O3/c1-3-4(2)5(7)6(8)9/h4H,3H2,1-2H3,(H,8,9)/p-1 HEPATONET_1.0_ABBREVIATION: HC01123 EHMN_ABBREVIATION: C00671
has only substance units: false
is: HMDB00491
type: Species
is: CHEBI:28654
initial amount: NaN
initial concentration: 1.0
name: 3-methyl-2-oxopentanoate
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110063#_9f78ead2_b631_4882_8822_c2bf348f20df
is encoded by: hsa:2348
initial concentration: NaN
initial amount: NaN
has only substance units: false
constant: false
type: Species
name: FOLR1
boundary condition: true
is: SBO:0000252

metaR EX vacc LPAREN e RPAREN
kinetic law: MODEL1310110063#
reactant: MODEL1310110063#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: vaccenic acid exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110063#_ab7d3be8_0f11_4905_8abc_e44f8a04c9f7
is: Q11203
is: SBO:0000252
has only substance units: false
name: ST3GAL3
initial concentration: NaN
is encoded by: hsa:6487
boundary condition: true
initial amount: NaN
constant: false
type: Species

metaR r0879
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11287335,PMID:11327718 NOTES:
is: SBO:0000185
reversible: false
name: TCDB:2.A.29.2.4 TCDB:2.A.29.16.1
fast: false
is described by: ECO:0000000
type: Reaction
reactant: MODEL1310110063#
product: MODEL1310110063#
kinetic law: MODEL1310110063#

metaM c8dc x
is: SBO:0000247
has only substance units: false
name: suberyl carnitine
is: HMDB06351
constant: false
initial concentration: 1.0
notes: FORMULA: C15H26NO6 CHARGE: -1
initial amount: NaN
type: Species
boundary condition: false

metaR RE3245C
product: MODEL1310110063#
fast: false
name: RE3245
type: Reaction
is: SBO:0000176
reactant: MODEL1310110063#
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:0 NOTES:IT - fixed proton
is described by: ECO:0000000
kinetic law: MODEL1310110063#

metaM 3octdeccrn c
initial concentration: 1.0
has only substance units: false
boundary condition: false
name: 3-hydroxyoctadecanoyl carnitine
notes: FORMULA: C25H49NO5 CHARGE: 0
initial amount: NaN
type: Species
constant: false
is: HMDB13336
is: SBO:0000247

metaR VLCSr
kinetic law: MODEL1310110063#
reversible: false
product: MODEL1310110063#
type: Reaction
is described by: ECO:0000269
name: Very-long-chain-fatty-acid-CoA ligase
modifier: MODEL1310110063#
is: SBO:0000176
reactant: MODEL1310110063#
fast: false
is version of: http://identifiers.org/ec-code/6.2.1.3
notes: GENE_ASSOCIATION: (11001.1) SUBSYSTEM: Bile acid synthesis EC Number: 6.2.1.7 Confidence Level: 4 AUTHORS: NOTES:from uniprot and lit - see human recon lit refs divalent cation requirement - unclear which one, reaction inhibited in the presence of EDTA (may just be MgATP or MgATP) - see Kelley and Vessey Biochimica et Biophysica Acta (1994) 1209: 51-55 temporarily will have H+ balance reaction NJ

metaR S6TASE19ly
kinetic law: MODEL1310110063#
fast: false
type: Reaction
reversible: true
is version of: http://identifiers.org/ec-code/3.1.6.14
modifier: MODEL1310110063#
is: SBO:0000176
is described by: ECO:0000000
name: N-acetylglucosamine-6-sulfatase, lysosomal
product: MODEL1310110063#
reactant: MODEL1310110063#
notes: GENE_ASSOCIATION: (2799.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.1.6.14 Confidence Level: 4 AUTHORS: PMID:3196333,PMID:3689314,PMID:3689315 NOTES:NCD

http://identifiers.org/biomodels.db/MODEL1310110063#_d16f17d2_e71d_42ec_85dd_5914649bd246
type: Species
is encoded by: hsa:8693
initial concentration: NaN
has only substance units: false
initial amount: NaN
is: Q8N4A0
constant: false
is: SBO:0000252
boundary condition: true
name: GALNT4

metaR S3TASE2ly
type: Reaction
fast: false
is described by: ECO:0000000
is: SBO:0000176
name: N-acetylglucosamine-3-sulfatase, lysosomal
product: MODEL1310110063#
reactant: MODEL1310110063#
notes: GENE_ASSOCIATION: SUBSYSTEM: Heparan sulfate degradation EC Number: 3.1.6.15 Confidence Level: 4 AUTHORS: PMID:7396957,PMID:8993162 NOTES:NCD
kinetic law: MODEL1310110063#
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110063#_d3b57380_f2b6_4153_8ed2_88657c8eb25a
initial concentration: NaN
name: ALDH1A3
has only substance units: false
is encoded by: hsa:220
type: Species
boundary condition: true
initial amount: NaN
is: P47895
is: SBO:0000252
constant: false

metaM HC02175 e
initial concentration: 1.0
name: caprate
boundary condition: false
type: Species
constant: false
is: SBO:0000247
initial amount: NaN
notes: FORMULA: C10H19O2 CHARGE: -1 INCHI: InChI=1S/C10H20O2/c1-2-3-4-5-6-7-8-9-10(11)12/h2-9H2,1H3,(H,11,12)/p-1
has only substance units: false
is: CHEBI:27689

metaR C141CPT1
kinetic law: MODEL1310110063#
product: MODEL1310110063#
reactant: MODEL1310110063#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: production of tetradecenoylcarnitine
type: Reaction

metaR RE0344C
notes: GENE_ASSOCIATION: (641372.1) or (641371.1) or (570.1) SUBSYSTEM: Fatty acid synthesis EC Number: 3.1.2.2 Confidence Level: 0 AUTHORS: PMID:10092594,PMID:10578051,PMID:16103133,PMID:16940157,PMID:9153233 NOTES:
kinetic law: MODEL1310110063#
reactant: MODEL1310110063#
reversible: true
is version of: http://identifiers.org/ec-code/2.3.1.65
name: RE0344
type: Reaction
modifier: MODEL1310110063#
fast: false
product: MODEL1310110063#
is version of: http://identifiers.org/ec-code/3.1.2.2
is described by: ECO:0000000
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110063#_9c2357d1_1484_4c15_8493_32f3fea8a991
boundary condition: true
type: Species
is encoded by: hsa:411
initial amount: NaN
is: SBO:0000252
constant: false
name: ARSB
has only substance units: false
initial concentration: NaN
is: A8K4A0

http://identifiers.org/biomodels.db/MODEL1310110063#_63a42962_d57f_409e_97a0_1fd42e152da8
has only substance units: false
is: SBO:0000252
is encoded by: hsa:26290
constant: false
initial amount: NaN
boundary condition: true
initial concentration: NaN
type: Species
is: Q9NY28
name: GALNT8

metaR r2380
reactant: MODEL1310110063#
is described by: ECO:0000000
is: SBO:0000185
product: MODEL1310110063#
reversible: true
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:16919238,PMID:17173541,PMID:18406340,PMID:8132483 NOTES:
kinetic law: MODEL1310110063#
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
type: Reaction

metaR S6T8g
name: galactose/N-acetylglucosamine 6-O-sulfotransferase, Golgi apparatus
type: Reaction
reactant: MODEL1310110063#
fast: false
notes: GENE_ASSOCIATION: (23563.2) or (9435.1) or (23563.1) or (10164.1) or (4166.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: Confidence Level: 4 AUTHORS: PMID:10330415,PMID:10491328,PMID:10913333,PMID:11278593,PMID:12403612,PMID:12855678,PMID:9722682 NOTES:NCD
is: SBO:0000176
is described by: ECO:0000000
kinetic law: MODEL1310110063#
reversible: false
product: MODEL1310110063#
modifier: MODEL1310110063#

metaM ttdca e
initial concentration: 1.0
is: CHEBI:30807
is: SBO:0000247
type: Species
has only substance units: false
notes: FORMULA: C14H27O2 CHARGE: -1 EHMN_ABBREVIATION: C06424
is: C06424
is: HMDB00806
constant: false
boundary condition: false
initial amount: NaN
name: tetradecanoate (n-C14:0)

http://identifiers.org/biomodels.db/MODEL1310110063#_480f5c1e_c23a_4d61_a580_40370426186e
constant: false
initial amount: NaN
type: Species
initial concentration: NaN
boundary condition: true
is encoded by: hsa:AI620219
is: SBO:0000252
name: _AI620219_1_m
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110063#_caa9c195_9e01_4e4b_a783_fb9cb33408fa
is: B3KQH0
type: Species
initial amount: NaN
constant: false
initial concentration: NaN
name: SLC35C1
is: SBO:0000252
boundary condition: true
is encoded by: hsa:55343
has only substance units: false

metaM n2m2masn g
constant: false
notes: FORMULA: C50H83N4O35X CHARGE: 0
initial concentration: 1.0
is: C11530
name: ((N-acetyl-D-glucosaminyl)2-(alpha-D-mannosyl)2-beta-D-mannosyl-diacetylchitobiosyl)-L-asparagine (protein)
initial amount: NaN
boundary condition: false
has only substance units: false
is: SBO:0000247
type: Species

metaM vacccoa c
is: SBO:0000247
boundary condition: false
is: http://identifiers.org/pubchem.compound/9543677
notes: FORMULA: C39H64N7O17P3S CHARGE: -4 INCHI: InChI=1/C39H68N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-30(48)67-23-22-41-29(47)20-21-42-37(51)34(50)39(2,3)25-60-66(57,58)63-65(55,56)59-24-28-33(62-64(52,53)54)32(49)38(61-28)46-27-45-31-35(40)43-26-44-36(31)46/h9-10,26-28,32-34,38,49-50H,4-8,11-25H2,1-3H3,(H,41,47)(H,42,51)(H,55,56)(H,57,58)(H2,40,43,44)(H2,52,53,54)/b10-9+/t28-,32-,33?,34+,38-/m1/s1
initial concentration: 1.0
type: Species
has only substance units: false
constant: false
is: HMDB06521
initial amount: NaN
name: vaccenyl coenzyme A

metaR FACOAL180i
is version of: http://identifiers.org/ec-code/6.2.1.3
kinetic law: MODEL1310110063#
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (22305.2) or (2181.2) or (51703.1) or (2181.1) or (2180.1) or (22305.1) SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 4 AUTHORS: NOTES:TV catalyzed by acyl-CoA synthetases
product: MODEL1310110063#
reactant: MODEL1310110063#
fast: false
is: SBO:0000176
reversible: false
modifier: MODEL1310110063#
name: C180 fatty acid activation
type: Reaction

metaM hs deg7 l
name: heparan sulfate, degradation product 7
constant: false
is: SBO:0000247
is: CHEBI:17180
boundary condition: false
notes: FORMULA: C67H99N4O80S8 CHARGE: -9
has only substance units: false
is: HMDB01352
initial amount: NaN
type: Species
initial concentration: 1.0

metaR r0130
name: gamma-glutamyltranspeptidase Glutathione metabolism EC:3.4.11.4
fast: false
notes: GENE_ASSOCIATION: (LOC374569.1) SUBSYSTEM: Glutathione metabolism EC Number: 3.4.11.4 Confidence Level: 0 AUTHORS: PMID:1968061,PMID:3511062 NOTES:
is described by: ECO:0000000
product: MODEL1310110063#
reactant: MODEL1310110063#
reversible: true
modifier: MODEL1310110063#
kinetic law: MODEL1310110063#
is: SBO:0000176
type: Reaction

metaR MTHFD2m
type: Reaction
reversible: true
fast: false
kinetic law: MODEL1310110063#
is: SBO:0000176
product: MODEL1310110063#
is version of: http://identifiers.org/ec-code/3.5.4.9
reactant: MODEL1310110063#
is described by: ECO:0000254
notes: GENE_ASSOCIATION: (10797.1) SUBSYSTEM: Folate metabolism EC Number: 1.5.1.5 Confidence Level: 2 AUTHORS: PMID:8218174 NOTES:NCD
modifier: MODEL1310110063#
name: methylenetetrahydrofolate dehydrogenase (NAD), mitochondrial

http://identifiers.org/biomodels.db/MODEL1310110063#_a749f3a9_9f8d_41f7_9f93_458299e7df66
initial concentration: NaN
boundary condition: true
is: SBO:0000252
is: Q9NVE7
initial amount: NaN
constant: false
type: Species
name: PANK4
has only substance units: false
is encoded by: hsa:55229

metaR TETPENT3t
reversible: true
reactant: MODEL1310110063#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11788354,PMID:12864740 NOTES:NJ
is described by: ECO:0000000
is: SBO:0000185
type: Reaction
name: fatty acid transport via diffusion
product: MODEL1310110063#
fast: false
kinetic law: MODEL1310110063#

metaR DOCO13EFATP
kinetic law: MODEL1310110063#
product: MODEL1310110063#
reactant: MODEL1310110063#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: absorption or uptake of 13-docosenoic acid into cells
type: Reaction

metaR DPPS
product: MODEL1310110063#
is: SBO:0000176
reversible: false
fast: false
is described by: ECO:0000134
name: decaprenyl synthase
notes: GENE_ASSOCIATION: SUBSYSTEM: Miscellaneous EC Number: Confidence Level: 2 AUTHORS: PMID:16262699 NOTES:by analogy to other dimethyl transferase rxns. See PMID: 10586494, human interemidate (from C15 ->C50) not explicitly determined yet, however it is known to occur since this pathway is essential in Q10 synthesis. For human metabolism: may be associated w/ GeneID: 23590 TPRT - recheck lit in future IT and NJ
kinetic law: MODEL1310110063#
type: Reaction
reactant: MODEL1310110063#

metaR NADPtru
name: NADP transporter, endoplasmic reticulum
kinetic law: MODEL1310110063#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: NOTES:diffusion - but unidirectional output from ER (to avoid loops w/ NAD/NADP) NJ
reactant: MODEL1310110063#
reversible: false
is described by: ECO:0000000
fast: false
product: MODEL1310110063#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110063#_89fd68b8_413d_42ed_a688_37dfcbe3349e
is: SBO:0000252
constant: false
name: PKLR
type: Species
is encoded by: hsa:5313
has only substance units: false
is: P30613
boundary condition: true
initial amount: NaN
initial concentration: NaN

metaM 2ddecdicoa x
has only substance units: false
initial concentration: 1.0
constant: false
name: 2,6-dodecadienoylcoa
notes: FORMULA: C33H50N7O17P3S CHARGE: -4
initial amount: NaN
is: C05279
is: SBO:0000247
boundary condition: false
is: HMDB11123
type: Species

metaR C160CPT1
is: SBO:0000176
type: Reaction
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (126129.1) or (1375.3) or (1374.1) or (1375.2) or (1375.1) or (1375.4) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.21 Confidence Level: 4 AUTHORS: PMID:1988962 NOTES:
fast: false
name: production of Palmitoylcarnitine
reversible: false
is version of: http://identifiers.org/ec-code/2.3.1.21
product: MODEL1310110063#
reactant: MODEL1310110063#
kinetic law: MODEL1310110063#
modifier: MODEL1310110063#

metaR DNDPt15m
name: dUDP transport via dGDP antiport
type: Reaction
is: SBO:0000185
reactant: MODEL1310110063#
modifier: MODEL1310110063#
is described by: ECO:0000269
fast: false
reversible: false
product: MODEL1310110063#
kinetic law: MODEL1310110063#
notes: GENE_ASSOCIATION: (60386.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:11226231 NOTES:IT

http://identifiers.org/biomodels.db/MODEL1310110063#_0cb4fd01_3bd4_4132_acdc_78746b7e0fa8
has only substance units: false
initial amount: NaN
boundary condition: true
type: Species
initial concentration: NaN
is: SBO:0000252
constant: false
name: MVD
is encoded by: hsa:4597
is: P53602

metaM HC02175 c
is: CHEBI:27689
type: Species
has only substance units: false
constant: false
initial concentration: 1.0
boundary condition: false
initial amount: NaN
name: caprate
notes: FORMULA: C10H19O2 CHARGE: -1 INCHI: InChI=1S/C10H20O2/c1-2-3-4-5-6-7-8-9-10(11)12/h2-9H2,1H3,(H,11,12)/p-1
is: SBO:0000247

metaM xol7ah2 c
type: Species
initial concentration: 1.0
has only substance units: false
boundary condition: false
is: SBO:0000247
is: HMDB06893
constant: false
initial amount: NaN
notes: FORMULA: C27H48O2 CHARGE: 0 INCHI: InChI=1S/C27H48O2/c1-17(2)7-6-8-18(3)21-9-10-22-25-23(12-14-27(21,22)5)26(4)13-11-20(28)15-19(26)16-24(25)29/h17-25,28-29H,6-16H2,1-5H3/t18-,19+,20-,21-,22+,23+,24-,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01461 EHMN_ABBREVIATION: C05452
is: CHEBI:28047
name: 5beta-cholestane-3alpha,7alpha-diol

metaR RE1807M
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/1.14.13.15
name: RE1807
type: Reaction
fast: false
is: SBO:0000176
kinetic law: MODEL1310110063#
reversible: true
modifier: MODEL1310110063#
product: MODEL1310110063#
reactant: MODEL1310110063#
notes: GENE_ASSOCIATION: (1593.1) SUBSYSTEM: Bile acid synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:9660774 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110063#_cebef1a4_f226_4d80_a2da_68bf3e1bb9bf
type: Species
name: ECHS1
constant: false
initial amount: NaN
is: SBO:0000252
has only substance units: false
initial concentration: NaN
is encoded by: hsa:1892
is: P30084
boundary condition: true

metaR IDOURtly
name: iduronate transport into lysososme
product: MODEL1310110063#
reversible: true
notes: GENE_ASSOCIATION: (26503.1) SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 4 AUTHORS: PMID:10581036,PMID:2768261,PMID:9852127 NOTES:H symport into lysososome. See PMID: 2768261 and PMID: 10581036 (for human evidence). Sialic acid storage disorders (due to transporter mutations) require import and export e.g. PMID: 2768266 NJ renamed from GLCURlt to GLCURtly - NCD added IdoA reaction - NCD
is: SBO:0000185
fast: false
type: Reaction
kinetic law: MODEL1310110063#
modifier: MODEL1310110063#
reactant: MODEL1310110063#
is described by: ECO:0000269

http://identifiers.org/biomodels.db/MODEL1310110063#_4d5f5a90_de36_4fc3_8fd9_17db9f777332
constant: false
initial amount: NaN
initial concentration: NaN
boundary condition: true
type: Species
has only substance units: false
name: DHCR24
is encoded by: hsa:1718
is: Q15392
is: SBO:0000252

metaM amet c
boundary condition: false
name: S-Adenosyl-L-methionine
has only substance units: false
constant: false
initial amount: NaN
notes: FORMULA: C15H23N6O5S CHARGE: 1 HEPATONET_1.0_ABBREVIATION: HC00029 EHMN_ABBREVIATION: C00019
is: HMDB01185
is: CHEBI:15414
is: C00019
is: SBO:0000247
initial concentration: 1.0
type: Species

metaR SERALANaEx
reversible: false
is: SBO:0000185
name: L-alanine/L-serine Na-dependent exchange (Ser-L in)
product: MODEL1310110063#
is described by: ECO:0000269
kinetic law: MODEL1310110063#
fast: false
reactant: MODEL1310110063#
notes: GENE_ASSOCIATION: (6509.1) or (6510.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14530974 NOTES:SAB see Kanai and Hediger 2004 (2003), PMID 14530974
type: Reaction
modifier: MODEL1310110063#

http://identifiers.org/biomodels.db/MODEL1310110063#_cd47fc6d_874a_4a3f_9356_0b59ee8ecd11
is encoded by: hsa:64077
is: SBO:0000252
is: Q9H008
initial amount: NaN
name: LHPP
has only substance units: false
constant: false
boundary condition: true
initial concentration: NaN
type: Species

metaR 3MOPte
kinetic law: MODEL1310110063#
product: MODEL1310110063#
reactant: MODEL1310110063#
is described by: ECO:0000134
name: Transport of 3-methyl-2-oxopentanoate
is: SBO:0000185
fast: false
type: Reaction
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:

http://identifiers.org/biomodels.db/MODEL1310110063#_71e861c2_098b_48f9_bfd7_0666d0bed33c
has part: Q9P2X0
initial concentration: NaN
is encoded by: hsa:54344
name: DPM3:DPM1:DPM2
is: SBO:0000297
is encoded by: hsa:8818
has only substance units: false
constant: false
boundary condition: true
type: Species
initial amount: NaN

metaR COQ3m
modifier: MODEL1310110063#
reversible: false
is described by: ECO:0000269
kinetic law: MODEL1310110063#
name: methyltransferase COQ3
type: Reaction
is version of: http://identifiers.org/ec-code/2.1.1.114
notes: GENE_ASSOCIATION: (51805.1) SUBSYSTEM: Ubiquinone synthesis EC Number: Confidence Level: 4 AUTHORS: PMID:10777520,PMID:11051212,PMID:1965190,PMID:7380842 NOTES:_2.1.1.114 IT
fast: false
product: MODEL1310110063#
reactant: MODEL1310110063#
is: SBO:0000176

metaM 2octdectecoa m
boundary condition: false
name: 2,6,9,12-octadecatetraenoylcoa
has only substance units: false
is: SBO:0000247
notes: FORMULA: C39H58N7O17P3S CHARGE: -4
initial amount: NaN
is: http://identifiers.org/pubchem.compound/5280355
type: Species
constant: false
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110063#_ce27381f_71be_449e_ac52_0e1cd5949a3c
is: A7E2E5
is encoded by: hsa:5140
boundary condition: true
is: SBO:0000252
name: PDE3B
constant: false
initial amount: NaN
initial concentration: NaN
has only substance units: false
type: Species

metaM ksi pre25 g
name: keratan sulfate I biosynthesis, precursor 25
is: SBO:0000247
initial amount: NaN
type: Species
is: CHEBI:58053
boundary condition: false
initial concentration: 1.0
notes: FORMULA: C199H319N14O163S7X CHARGE: -8
has only substance units: false
is: C00130
constant: false
is: HMDB00175

metaR r2497
is described by: ECO:0000000
reactant: MODEL1310110063#
reversible: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 0 AUTHORS: PMID:18619829 NOTES:
type: Reaction
fast: false
is: SBO:0000185
kinetic law: MODEL1310110063#
name: ATP-binding Cassette (ABC) TCDB:3.A.1.203.3
product: MODEL1310110063#

metaR FAOXC80
notes: GENE_ASSOCIATION: (35.1) or (34.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.99.3 Confidence Level: 4 AUTHORS: PMID:2565344,PMID:3035565 NOTES:TDV (9/7/2004) Other enzymes: 1.3.3.6, 4.2.1.74, 4.2.1.17, 1.1.1.35, 1.1.1.211
is version of: http://identifiers.org/ec-code/1.3.8.1
reversible: false
reactant: MODEL1310110063#
type: Reaction
kinetic law: MODEL1310110063#
is: SBO:0000176
is described by: ECO:0000269
product: MODEL1310110063#
modifier: MODEL1310110063#
is version of: http://identifiers.org/ec-code/1.3.99.3
name: Beta oxidation of med/long chain fatty acid
fast: false

metaR G16MT U
reversible: false
type: Reaction
reactant: MODEL1310110063#
notes: GENE_ASSOCIATION: SUBSYSTEM: N-glycan synthesis EC Number: Confidence Level: 0 AUTHORS: NOTES:
is: SBO:0000176
kinetic law: MODEL1310110063#
product: MODEL1310110063#
name: Glycolipid 1,6-alpha-D-mannosyltransferase (uterus)
is described by: ECO:0000000
fast: false

http://identifiers.org/biomodels.db/MODEL1310110063#_3a258426_dbdd_415d_94cc_e549f9d27c05
boundary condition: true
name: RRM1
initial concentration: NaN
constant: false
has only substance units: false
is: SBO:0000252
is encoded by: hsa:6240
initial amount: NaN
is: P23921
type: Species

metaR r1669
fast: false
is: SBO:0000185
name: Y+LAT2 Utilized transport
type: Reaction
modifier: MODEL1310110063#
kinetic law: MODEL1310110063#
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reversible: true
reactant: MODEL1310110063#
product: MODEL1310110063#
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110063#_92aee840_13b0_4122_b3b8_bc1c4aac0339
name: HSD3B1
is: SBO:0000252
type: Species
constant: false
has only substance units: false
initial amount: NaN
initial concentration: NaN
boundary condition: true
is encoded by: hsa:3283
is: P14060

metaR HACD1m
notes: GENE_ASSOCIATION: (3028.1) or (3033.1) or (3030.1) and (3032.1) SUBSYSTEM: Tryptophan metabolism EC Number: 1.1.1.35 Confidence Level: 1 AUTHORS: PMID:17143551,PMID:17143552 NOTES:Same as EC 1.1.1.157 SAB mito. some physiological
is: SBO:0000176
reversible: true
reactant: MODEL1310110063#
name: 3-hydroxyacyl-CoA dehydrogenase (acetoacetyl-CoA) (mitochondria)
type: Reaction
is version of: http://identifiers.org/ec-code/2.3.1.16
fast: false
is version of: http://identifiers.org/ec-code/4.2.1.17
modifier: MODEL1310110063#
kinetic law: MODEL1310110063#
is version of: http://identifiers.org/ec-code/1.1.1.35
product: MODEL1310110063#
is described by: ECO:0000134

metaM 2docohexecoa m
initial concentration: 1.0
is: http://identifiers.org/pubchem.compound/24892790
boundary condition: false
initial amount: NaN
has only substance units: false
constant: false
name: 2,7,10,13,16,19-docosahexenoylcoa
is: SBO:0000247
notes: FORMULA: C43H62N7O17P3S CHARGE: -4
type: Species

http://identifiers.org/biomodels.db/MODEL1310110063#_9e2d814d_6e53_488e_8401_e243b5690bca
name: ST20
type: Species
initial amount: NaN
is: SBO:0000252
initial concentration: NaN
is encoded by: hsa:400410
boundary condition: true
constant: false
is: Q9HBF5
has only substance units: false

metaM omhdecacid c
initial amount: NaN
is: HMDB00672
notes: FORMULA: C10H19O3 CHARGE: -1
name: w-hydroxydecanoicacid
is: SBO:0000247
initial concentration: 1.0
is: C08260
constant: false
type: Species
has only substance units: false
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110063#_14e71fc0_3b94_4f21_9e04_f46d57ad48c3
is encoded by: hsa:5138
type: Species
initial amount: NaN
initial concentration: NaN
is: Q8IW54
is: SBO:0000252
boundary condition: true
has only substance units: false
constant: false
name: PDE2A

http://identifiers.org/biomodels.db/MODEL1310110063#_32124d73_1cf5_457d_b695_002255eb80f2
is: SBO:0000252
name: MECR
has only substance units: false
initial amount: NaN
constant: false
is: Q9BV79
boundary condition: true
is encoded by: hsa:51102
initial concentration: NaN
type: Species

http://identifiers.org/biomodels.db/MODEL1310110063#_9e10f029_a09a_4848_a48d_9185c216c7f4
initial amount: NaN
is: SBO:0000252
is: Q67FW5
type: Species
constant: false
boundary condition: true
has only substance units: false
initial concentration: NaN
name: B3GNTL1
is encoded by: hsa:146712

metaR UGALNACtg
is described by: ECO:0000269
kinetic law: MODEL1310110063#
product: MODEL1310110063#
notes: GENE_ASSOCIATION: (7355.1) SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 4 AUTHORS: PMID:11784306,PMID:8889805,PMID:9010752,PMID:9399569,PMID:9562625 NOTES:NCD
fast: false
reactant: MODEL1310110063#
is: SBO:0000185
name: UDP-GalNAc Golgi transport via CMP antiport
reversible: true
modifier: MODEL1310110063#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110063#_fdb610eb_9b4d_49ed_953f_28b7100190eb
constant: false
type: Species
boundary condition: true
has only substance units: false
is: P16219
initial amount: NaN
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:35
name: ACADS

metaM stcoa c
initial concentration: 1.0
is: C00412
boundary condition: false
constant: false
is: CHEBI:57394
initial amount: NaN
name: Stearoyl-CoA (n-C18:0CoA)
type: Species
is: SBO:0000247
is: HMDB01114
has only substance units: false
notes: FORMULA: C39H66N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00338 EHMN_ABBREVIATION: C00412

metaR ECOAH1m
product: MODEL1310110063#
reactant: MODEL1310110063#
is version of: http://identifiers.org/ec-code/4.2.1.17
fast: false
notes: GENE_ASSOCIATION: (549.1) or (3030.1) and (3032.1) or (1892.1) SUBSYSTEM: Tryptophan metabolism EC Number: 4.2.1.17 Confidence Level: 2 AUTHORS: PMID:7558027 NOTES:SAB for mito
is: SBO:0000176
kinetic law: MODEL1310110063#
is version of: http://identifiers.org/ec-code/4.2.1.18
is described by: ECO:0000304
modifier: MODEL1310110063#
reversible: true
name: 3-hydroxyacyl-CoA dehydratase (3-hydroxybutanoyl-CoA) (mitochondria)
type: Reaction
is version of: http://identifiers.org/ec-code/2.3.1.16

metaR MG2er
name: mannosyl-oligosaccharide glucosidase, endoplasmic reticulum
fast: false
reversible: false
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: N-glycan synthesis EC Number: Confidence Level: 0 AUTHORS: NOTES:EC-3.2.1.- NCD
type: Reaction
kinetic law: MODEL1310110063#
reactant: MODEL1310110063#
is described by: ECO:0000000
product: MODEL1310110063#

metaR GALASE5ly
product: MODEL1310110063#
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/3.2.1.18
kinetic law: MODEL1310110063#
reactant: MODEL1310110063#
is version of: http://identifiers.org/ec-code/3.4.16.5
fast: false
modifier: MODEL1310110063#
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) or (5476.1) and (2720.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.23 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD
is version of: http://identifiers.org/ec-code/3.2.1.23
reversible: false
is version of: http://identifiers.org/ec-code/3.1.6.4
is: SBO:0000176
name: beta-galactosidase, lysosomal
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110063#_f0f5144c_bf95_419d_8387_904f92191c6b
has only substance units: false
constant: false
is: Q53XN1
is encoded by: hsa:1351
initial amount: NaN
boundary condition: true
type: Species
initial concentration: NaN
name: COX8A
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110063#_588b00c1_be87_486a_95d3_918779759011
is encoded by: hsa:51292
is: SBO:0000252
boundary condition: true
constant: false
name: GMPR2
has only substance units: false
initial concentration: NaN
initial amount: NaN
type: Species
is: Q9P2T1

http://identifiers.org/biomodels.db/MODEL1310110063#_b85a9116_f1c5_4487_88e4_186ec6454391
initial amount: NaN
is: Q548A7
constant: false
name: SLC26A6
type: Species
initial concentration: NaN
is encoded by: hsa:65010
boundary condition: true
is: SBO:0000252
has only substance units: false

metaR r2386
product: MODEL1310110063#
modifier: MODEL1310110063#
reactant: MODEL1310110063#
kinetic law: MODEL1310110063#
is described by: ECO:0000000
is: SBO:0000185
notes: GENE_ASSOCIATION: (215.1) or (U52111.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172 NOTES:
reversible: false
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
fast: false
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110063#_28369afd_08d8_4d23_bb83_2ee1303a6f59
is: SBO:0000252
type: Species
is encoded by: hsa:5320
initial concentration: NaN
constant: false
is: P14555
name: PLA2G2A
boundary condition: true
initial amount: NaN
has only substance units: false

metaR MI14P4P
name: inositol-1,4-bisphosphate 4-phosphatase
kinetic law: MODEL1310110063#
product: MODEL1310110063#
reactant: MODEL1310110063#
is: SBO:0000176
type: Reaction
reversible: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Inositol phosphate metabolism EC Number: Confidence Level: 2 AUTHORS: PMID:2906139 NOTES:NCD
is described by: ECO:0000000
fast: false

metaM Tn antigen g
initial concentration: 1.0
is: SBO:0000247
type: Species
constant: false
notes: FORMULA: C8H14NO5X CHARGE: 0
name: Tn antigen
is: C04383
has only substance units: false
initial amount: NaN
boundary condition: false

metaR PROt2r
is described by: ECO:0000304
reactant: MODEL1310110063#
modifier: MODEL1310110063#
product: MODEL1310110063#
type: Reaction
reversible: true
name: L-proline reversible transport via proton symport
kinetic law: MODEL1310110063#
notes: GENE_ASSOCIATION: (206358.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11390972,PMID:11959859 NOTES:NCD
is: SBO:0000185
fast: false

metaR DCSPTN1CPT2
product: MODEL1310110063#
kinetic law: MODEL1310110063#
reversible: false
modifier: MODEL1310110063#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (1376.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: NOTES:NJ
is version of: http://identifiers.org/ec-code/2.3.1.21
is: SBO:0000176
type: Reaction
name: carnitine transferase
reactant: MODEL1310110063#
fast: false

http://identifiers.org/biomodels.db/MODEL1310110063#_eb84bda5_be48_45c3_8073_a4bc4ca08084
initial amount: NaN
type: Species
name: MTMR6
is: Q9Y217
boundary condition: true
constant: false
initial concentration: NaN
is: SBO:0000252
has only substance units: false
is encoded by: hsa:9107

http://identifiers.org/biomodels.db/MODEL1310110063#_61af055c_bbab_4dbe_9dad_786af6ea4f06
initial concentration: NaN
boundary condition: true
is: SBO:0000252
has only substance units: false
initial amount: NaN
constant: false
name: _D29675_1_e
type: Species
is encoded by: hsa:D29675

metaR EX aicar LPAREN e RPAREN
kinetic law: MODEL1310110063#
reactant: MODEL1310110063#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: Exchange of 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide(2-)
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110063#_bcd36683_a324_4f6e_a5ac_5693f1e4330d
constant: false
is encoded by: hsa:113
initial concentration: NaN
is: P51828
initial amount: NaN
name: ADCY7
is: SBO:0000252
has only substance units: false
boundary condition: true
type: Species

metaR GLYt2r
modifier: MODEL1310110063#
reversible: true
reactant: MODEL1310110063#
product: MODEL1310110063#
notes: GENE_ASSOCIATION: (206358.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11390972,PMID:11959859 NOTES:NCD
type: Reaction
name: glycine reversible transport via proton symport
is described by: ECO:0000304
kinetic law: MODEL1310110063#
fast: false
is: SBO:0000185

metaR FATP7t
modifier: MODEL1310110063#
reactant: MODEL1310110063#
kinetic law: MODEL1310110063#
name: fatty acid electroneutral transport
is: SBO:0000185
reversible: true
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/6.2.1.3
is version of: http://identifiers.org/ec-code/6.2.1.7
notes: GENE_ASSOCIATION: (10998.1) or (11001.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10479480,PMID:12856180,PMID:15522816 NOTES:electroneutral transport NJ
product: MODEL1310110063#
fast: false
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110063#_5161d3e8_b93b_456e_85d6_27eb4d00c0fd
type: Species
initial concentration: NaN
initial amount: NaN
is: Q3I5F7
name: ACOT6
is: SBO:0000252
has only substance units: false
boundary condition: true
is encoded by: hsa:641372
constant: false

metaM omhdecacid r
initial amount: NaN
type: Species
name: w-hydroxydecanoicacid
is: HMDB06522
has only substance units: false
is: SBO:0000247
initial concentration: 1.0
notes: FORMULA: C10H19O3 CHARGE: -1
boundary condition: false
constant: false

http://identifiers.org/biomodels.db/MODEL1310110063#_df6dae9b_3f37_4426_8515_9238ca491744
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:H53099
name: _H53099_1_m
is: SBO:0000252
type: Species
constant: false
has only substance units: false
boundary condition: true

metaR PIK3
is version of: http://identifiers.org/ec-code/2.7.11.1
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/2.7.1.153
kinetic law: MODEL1310110063#
reversible: false
is version of: http://identifiers.org/ec-code/2.7.1.154
name: phosphatidylinositol 3-kinase
reactant: MODEL1310110063#
modifier: MODEL1310110063#
is version of: http://identifiers.org/ec-code/2.7.1.137
is: SBO:0000176
notes: GENE_ASSOCIATION: (5295.2 and 5291.1) or (23533.1 and 5294.1) or (5290.1 and 5295.1) or (5293.1 and 5295.3) or (5287.1) or (5286.1) or (5293.1 and 5296.1) or (5295.2 and 5293.1) or (5296.1 and 5291.1) or (5290.1 and 5295.3) or (5288.1) or (5290.1 and 8503.1) or (5291.1 and 5295.3) or (10870.1 and 5294.1) or (5291.1 and 8503.1) or (5293.1 and 5295.1) or (5296.1 and 5290.1) or (5289.1) or (5293.1 and 8503.1) or (5291.1 and 5295.1) or (5295.2 and 5290.1) SUBSYSTEM: Inositol phosphate metabolism EC Number: 2.7.1.137 Confidence Level: 4 AUTHORS: PMID:7624799,PMID:7628435,PMID:7713498,PMID:8246984,PMID:9113989,PMID:9337861,PMID:9830063,PMID:9878262 NOTES:NCD
product: MODEL1310110063#
type: Reaction
fast: false

metaM HC02149 c
is: CHEBI:28867
type: Species
initial concentration: 1.0
name: O-Propanoylcarnitine
boundary condition: false
constant: false
notes: FORMULA: C10H19NO4 CHARGE: 0 INCHI: InChI=1S/C10H19NO4/c1-5-10(14)15-8(6-9(12)13)7-11(2,3)4/h8H,5-7H2,1-4H3
has only substance units: false
is: SBO:0000247
initial amount: NaN

metaR r0871
kinetic law: MODEL1310110063#
name: Diffusion
product: MODEL1310110063#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14977409 NOTES:
is: SBO:0000185
reversible: true
fast: false
type: Reaction
reactant: MODEL1310110063#
is described by: ECO:0000000

metaR biomass reaction
reversible: false
type: Reaction
fast: false
product: MODEL1310110063#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: AUTHORS: NOTES:
is described by: ECO:0000134
name: biomass_reaction
is: SBO:0000185
reactant: MODEL1310110063#
kinetic law: MODEL1310110063#

http://identifiers.org/biomodels.db/MODEL1310110063#_f0056563_7543_481e_bc7f_9d6a97e73623
type: Species
initial concentration: NaN
has only substance units: false
is: Q8WWX8
initial amount: NaN
constant: false
is encoded by: hsa:115584
is: SBO:0000252
boundary condition: true
name: SLC5A11

metaM pan4p c
boundary condition: false
has only substance units: false
constant: false
initial concentration: 1.0
initial amount: NaN
notes: FORMULA: C11H21N2O7PS CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00681 EHMN_ABBREVIATION: C01134
is: SBO:0000247
name: Pantetheine 4'-phosphate
is: CHEBI:47942
type: Species
is: C01134
is: HMDB01416

metaM 3mop e
constant: false
notes: FORMULA: C6H9O3 CHARGE: -1 INCHI: InChI=1S/C6H10O3/c1-3-4(2)5(7)6(8)9/h4H,3H2,1-2H3,(H,8,9)/p-1
name: 3-methyl-2-oxopentanoate
has only substance units: false
boundary condition: false
type: Species
is: CHEBI:28654
initial amount: NaN
initial concentration: 1.0
is: SBO:0000247
is: HMDB00491

metaM 4abut m
has only substance units: false
boundary condition: false
initial amount: NaN
initial concentration: 1.0
is: C00334
is: CHEBI:16865
is: HMDB00112
name: 4-Aminobutanoate
type: Species
constant: false
notes: FORMULA: C4H9NO2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00284 EHMN_ABBREVIATION: C00334
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110063#_44371538_df5b_4fe6_a116_406c4a76bc13
constant: false
boundary condition: true
is: SBO:0000252
is encoded by: hsa:6319
type: Species
initial concentration: NaN
initial amount: NaN
name: SCD
has only substance units: false
is: O00767

metaR DCSPTN1CPT1
reactant: MODEL1310110063#
kinetic law: MODEL1310110063#
modifier: MODEL1310110063#
is: SBO:0000176
type: Reaction
product: MODEL1310110063#
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/2.3.1.21
fast: false
reversible: false
name: carnitine O-palmitoyltransferase
notes: GENE_ASSOCIATION: (1375.1) or (1375.3) or (1375.4) or (126129.1) or (1374.1) or (1375.2) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.21 Confidence Level: 4 AUTHORS: NOTES:NJ

http://identifiers.org/biomodels.db/MODEL1310110063#_9c7fa1c3_619a_4e79_ac96_0a372a852463
type: Species
boundary condition: true
is encoded by: hsa:26
name: ABP1
initial concentration: NaN
has only substance units: false
initial amount: NaN
constant: false
is: P19801
is: SBO:0000252

metaM ethamp c
is: SBO:0000247
notes: FORMULA: C2H7NO4P CHARGE: -1 INCHI: InChI=1S/C2H8NO4P/c3-1-2-7-8(4,5)6/h1-3H2,(H2,4,5,6)/p-1 HEPATONET_1.0_ABBREVIATION: HC00293 EHMN_ABBREVIATION: C00346
constant: false
initial concentration: 1.0
is: CHEBI:58190
is: HMDB00224
has only substance units: false
type: Species
name: ethamp[c]
initial amount: NaN
boundary condition: false

metaR 2DR1PP
reactant: MODEL1310110063#
type: Reaction
name: 2-deoxy-D-ribose 1-phosphate phosphorylase
reversible: false
is: SBO:0000176
kinetic law: MODEL1310110063#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Pyrimidine catabolism EC Number: 3.1.3.10 Confidence Level: 2 AUTHORS: PMID:9693094 NOTES:NCD
product: MODEL1310110063#
is described by: ECO:0000000

metaR FAOXC181C161x
kinetic law: MODEL1310110063#
product: MODEL1310110063#
reactant: MODEL1310110063#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta xoidation(C18:1-->C16:1)x
type: Reaction

metaR r2387
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
is described by: ECO:0000000
kinetic law: MODEL1310110063#
product: MODEL1310110063#
reactant: MODEL1310110063#
reversible: false
modifier: MODEL1310110063#
is: SBO:0000185
type: Reaction
notes: GENE_ASSOCIATION: (215.1) or (U52111.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172 NOTES:
fast: false

metaM 5mta e
notes: FORMULA: C11H15N5O3S CHARGE: 0
is: C00170
initial concentration: 1.0
name: 5-Methylthioadenosine
is: CHEBI:17509
constant: false
type: Species
boundary condition: false
is: SBO:0000247
is: HMDB01173
initial amount: NaN
has only substance units: false

metaR EX prostgh2 LPAREN e RPAREN
kinetic law: MODEL1310110063#
reactant: MODEL1310110063#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: prostaglandin H2(1-) exchange
type: Reaction

metaR EX gua LPAREN e RPAREN
kinetic law: MODEL1310110063#
reactant: MODEL1310110063#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Guanine exchange
type: Reaction

metaM HC01409 m
is: SBO:0000247
initial amount: NaN
boundary condition: false
constant: false
notes: FORMULA: C27H42N7O17P3S CHARGE: -4 INCHI: InChI=1S/C27H46N7O17P3S/c1-4-5-6-7-18(36)55-11-10-29-17(35)8-9-30-25(39)22(38)27(2,3)13-48-54(45,46)51-53(43,44)47-12-16-21(50-52(40,41)42)20(37)26(49-16)34-15-33-19-23(28)31-14-32-24(19)34/h14-16,20-22,26,37-38H,4-13H2,1-3H3,(H,29,35)(H,30,39)(H,43,44)(H,45,46)(H2,28,31,32)(H2,40,41,42)/t16-,20-,21-,22+,26-/m1/s1 EHMN_ABBREVIATION: C05270
is: CHEBI:27540
has only substance units: false
type: Species
name: Hexanoyl-CoA
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110063#_5a29c883_8c4c_4903_9b74_175f8b6fe1ba
boundary condition: true
has only substance units: false
initial amount: NaN
type: Species
name: _AU149534_1_m
is: SBO:0000252
is encoded by: hsa:AU149534
initial concentration: NaN
constant: false

http://identifiers.org/biomodels.db/MODEL1310110063#_e1aac044_2da8_4528_a594_aaaffc547d2f
is: SBO:0000252
is encoded by: hsa:6576
name: SLC25A1
constant: false
initial amount: NaN
initial concentration: NaN
is: D9HTE9
type: Species
boundary condition: true
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110063#_2b31d6cb_d81b_44e6_8308_dd0939e973fb
is: SBO:0000252
constant: false
initial amount: NaN
type: Species
is encoded by: hsa:4905
is: P46459
has only substance units: false
boundary condition: true
name: NSF
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110063#_612189fb_4b03_46e1_8382_0f8b9477702e
constant: false
is encoded by: hsa:767
initial amount: NaN
is: P35219
is: SBO:0000252
has only substance units: false
type: Species
boundary condition: true
name: CA8
initial concentration: NaN

metaM leu L m
initial concentration: 1.0
notes: FORMULA: C6H13NO2 CHARGE: 0 INCHI: InChI=1S/C6H13NO2/c1-4(2)3-5(7)6(8)9/h4-5H,3,7H2,1-2H3,(H,8,9)/t5-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00121 EHMN_ABBREVIATION: C00123
constant: false
is: CHEBI:15603
name: L-leucine
type: Species
is: HMDB00687
initial amount: NaN
boundary condition: false
has only substance units: false
is: SBO:0000247

metaR BILIRUBt2
fast: false
reactant: MODEL1310110063#
reversible: true
type: Reaction
modifier: MODEL1310110063#
kinetic law: MODEL1310110063#
product: MODEL1310110063#
is described by: ECO:0000269
name: bilirubin transport via bicarbonate countertransport
notes: GENE_ASSOCIATION: (10599.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10358072,PMID:12507753,PMID:9334206 NOTES:NJ
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110063#_23331b5c_78ff_468a_81d9_b8dcdaf9172d
is encoded by: hsa:AA664770
is: SBO:0000252
has only substance units: false
boundary condition: true
initial amount: NaN
initial concentration: NaN
type: Species
constant: false
name: _AA664770_1_m

http://identifiers.org/biomodels.db/MODEL1310110063#_3d73c8d8_8539_41d7_b655_918899c845cb
is: SBO:0000252
boundary condition: true
initial amount: NaN
is: Q9BYC2
has only substance units: false
initial concentration: NaN
constant: false
name: OXCT2
is encoded by: hsa:64064
type: Species

metaR r0434
is described by: ECO:0000000
kinetic law: MODEL1310110063#
reversible: true
is: SBO:0000176
product: MODEL1310110063#
notes: GENE_ASSOCIATION: (AI824319.1) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.21 Confidence Level: 0 AUTHORS: PMID:1735445,PMID:1988962,PMID:2355017,PMID:6361812,PMID:7892212 NOTES:
name: Palmitoyl-CoA:L-carnitine O-palmitoyltransferase Fatty acid metabolism EC:2.3.1.21
reactant: MODEL1310110063#
modifier: MODEL1310110063#
fast: false
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110063#_ad2795fe_09b7_47d4_be63_e492c3422aeb
name: MVK
is: SBO:0000252
boundary condition: true
is encoded by: hsa:4598
initial concentration: NaN
type: Species
constant: false
has only substance units: false
initial amount: NaN
is: B2RDU6

metaR MI145PP
is described by: ECO:0000269
is: SBO:0000176
fast: false
modifier: MODEL1310110063#
product: MODEL1310110063#
type: Reaction
is version of: http://identifiers.org/ec-code/3.1.3.56
is version of: http://identifiers.org/ec-code/3.1.3.86
kinetic law: MODEL1310110063#
reversible: false
reactant: MODEL1310110063#
name: inositol-1,4,5-trisphosphate 5-phosphatase
is version of: http://identifiers.org/ec-code/3.1.3.36
notes: GENE_ASSOCIATION: (3635.1) or (8867.2) or (3636.1) or (27124.2) or (8867.1) or (27124.1) or (3633.1) or (56623.1) or (3632.1) SUBSYSTEM: Inositol phosphate metabolism EC Number: 3.1.3.56 Confidence Level: 4 AUTHORS: PMID:10593988,PMID:10764818,PMID:15261714,PMID:2906139,PMID:7721860,PMID:8006039,PMID:8013665,PMID:8530088,PMID:8769125,PMID:9428629,PMID:9824312 NOTES:NCD

metaR EX CLPND LPAREN e RPAREN
kinetic law: MODEL1310110063#
reactant: MODEL1310110063#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: clupanodonic acid (docosapentaenoic (n-3)) exchange
type: Reaction

metaR r0139
product: MODEL1310110063#
modifier: MODEL1310110063#
kinetic law: MODEL1310110063#
fast: false
type: Reaction
reactant: MODEL1310110063#
reversible: true
is: SBO:0000176
notes: GENE_ASSOCIATION: (AI222095.1) or (AI697028.1) or (D87002.1) or (2678.1) or (728441.1) or (2687.1) or (2686.1) or (728226.1) or (NM_013421.1) SUBSYSTEM: Pyrimidine catabolism EC Number: 3.6.1.5 Confidence Level: 0 AUTHORS: PMID:15652174,PMID:16752921,PMID:17095758 NOTES:
name: CDP diphosphohydrolase Pyrimidine metabolism EC:3.6.1.5
is version of: http://identifiers.org/ec-code/2.3.2.2
is described by: ECO:0000000

metaR EX HC02203 LPAREN e RPAREN
kinetic law: MODEL1310110063#
reactant: MODEL1310110063#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: prostaglandin-a2 exchange
type: Reaction

metaM tymsf e
is: SBO:0000247
constant: false
has only substance units: false
type: Species
initial amount: NaN
name: Tyramine O-sulfate
initial concentration: 1.0
boundary condition: false
notes: FORMULA: C8H11NO4S CHARGE: 0 INCHI: InChI=1/C8H11NO4S/c9-6-5-7-1-3-8(4-2-7)13-14(10,11)12/h1-4H,5-6,9H2,(H,10,11,12)
is: HMDB06409

metaR GLNCYSNaEx
kinetic law: MODEL1310110063#
reactant: MODEL1310110063#
fast: false
reversible: false
type: Reaction
notes: GENE_ASSOCIATION: (6510.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14530974 NOTES:SAB see Kanai and Hediger 2004 (2003), PMID 14530974
modifier: MODEL1310110063#
is: SBO:0000185
is described by: ECO:0000269
name: L-cysteine/L-glutamine Na-dependent exchange (Gln-L in)
product: MODEL1310110063#

metaR r2388
notes: GENE_ASSOCIATION: (215.1) or (U52111.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172 NOTES:
fast: false
modifier: MODEL1310110063#
type: Reaction
kinetic law: MODEL1310110063#
product: MODEL1310110063#
reactant: MODEL1310110063#
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
is: SBO:0000185
reversible: false
is described by: ECO:0000000

metaR APOC LYS BTNP
reactant: MODEL1310110063#
reversible: false
type: Reaction
name: proteolysis of apoC-Lys-btn
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Biotin metabolism EC Number: Confidence Level: 2 AUTHORS: NOTES:
kinetic law: MODEL1310110063#
product: MODEL1310110063#
is described by: ECO:0000000
fast: false

metaR THRGLYexR
notes: GENE_ASSOCIATION: (56301.1) and (6520.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10734121,PMID:10863037,PMID:14770310 NOTES:
is: SBO:0000185
product: MODEL1310110063#
type: Reaction
is described by: ECO:0000304
name: L-threonine/glycine reversible exchange
modifier: MODEL1310110063#
reversible: true
fast: false
reactant: MODEL1310110063#
kinetic law: MODEL1310110063#

metaR r2389
is described by: ECO:0000000
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
reactant: MODEL1310110063#
kinetic law: MODEL1310110063#
product: MODEL1310110063#
is: SBO:0000185
type: Reaction
reversible: false
fast: false
modifier: MODEL1310110063#
notes: GENE_ASSOCIATION: (215.1) or (U52111.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172 NOTES:

metaR CHOLt4
name: choline, sodium cotransport
is: SBO:0000185
reversible: true
notes: GENE_ASSOCIATION: (60482.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:11027560,PMID:11068039,PMID:12675135 NOTES:NCD
reactant: MODEL1310110063#
kinetic law: MODEL1310110063#
modifier: MODEL1310110063#
product: MODEL1310110063#
type: Reaction
is described by: ECO:0000269
fast: false

metaM HC02205 e
constant: false
name: prostaglandin-b2
is: CHEBI:28099
boundary condition: false
initial concentration: 1.0
notes: FORMULA: C20H29O4 CHARGE: -1 INCHI: InChI=1S/C20H30O4/c1-2-3-6-9-17(21)14-12-16-13-15-19(22)18(16)10-7-4-5-8-11-20(23)24/h4,7,12,14,17,21H,2-3,5-6,8-11,13,15H2,1H3,(H,23,24)/b7-4-,14-12+/t17-/m0/s1 EHMN_ABBREVIATION: C05954
is: SBO:0000247
initial amount: NaN
has only substance units: false
type: Species

metaM lnlnca c
is: HMDB01388
boundary condition: false
type: Species
is: CHEBI:32387
has only substance units: false
is: SBO:0000247
notes: FORMULA: C18H29O2 CHARGE: -1 INCHI: InChI=1S/C18H30O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20/h3-4,6-7,9-10H,2,5,8,11-17H2,1H3,(H,19,20)/p-1/b4-3-,7-6-,10-9-
initial concentration: 1.0
name: alpha-linolenate
constant: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110063#_7b095a3a_4958_4cae_aa70_c0f729ae597f
initial amount: NaN
type: Species
is: Q6TCH8
boundary condition: true
initial concentration: NaN
is encoded by: hsa:10873
constant: false
name: ME3
is: SBO:0000252
has only substance units: false

metaR r2382
kinetic law: MODEL1310110063#
type: Reaction
product: MODEL1310110063#
reactant: MODEL1310110063#
is described by: ECO:0000000
fast: false
notes: GENE_ASSOCIATION: (215.1) or (U52111.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172 NOTES:
modifier: MODEL1310110063#
is: SBO:0000185
reversible: false
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2

http://identifiers.org/biomodels.db/MODEL1310110063#_ec25882e_97f8_4ea5_a2d7_8849376c9093
is encoded by: hsa:1962
initial amount: NaN
boundary condition: true
name: EHHADH
initial concentration: NaN
is: Q9NY65
has only substance units: false
is: SBO:0000252
type: Species
constant: false

metaM dolglcp U c
is: SBO:0000247
initial amount: NaN
notes: FORMULA: C1085H1780O90P10 CHARGE: -10 INCHI: InChI=1S/C31H55O9P/c1-22(2)11-7-12-23(3)13-8-14-24(4)15-9-16-25(5)17-10-18-26(6)19-20-38-41(36,37)40-31-30(35)29(34)28(33)27(21-32)39-31/h11,13,15,17,26-35H,7-10,12,14,16,18-21H2,1-6H3,(H,36,37)/b23-13+,24-15+,25-17-/t26?,27-,28-,29+,30-,31+/m1/s1
initial concentration: 1.0
is: CHEBI:15812
has only substance units: false
name: Dolichyl beta-D-glucosyl phosphate, human uterine homolog
type: Species
constant: false
boundary condition: false

metaM asp L c
is: CHEBI:29991
name: L-aspartate(1-)
constant: false
type: Species
is: HMDB00191
initial concentration: 1.0
is: SBO:0000247
notes: FORMULA: C4H6NO4 CHARGE: -1 INCHI: InChI=1S/C4H7NO4/c5-2(4(8)9)1-3(6)7/h2H,1,5H2,(H,6,7)(H,8,9)/p-1/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00055
initial amount: NaN
has only substance units: false
boundary condition: false

metaR FACOAL1822
kinetic law: MODEL1310110063#
modifier: MODEL1310110063#
notes: GENE_ASSOCIATION: (2180.1) SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 4 AUTHORS: PMID:15292367 NOTES:NJ
type: Reaction
is version of: http://identifiers.org/ec-code/6.2.1.3
reactant: MODEL1310110063#
reversible: true
fast: false
product: MODEL1310110063#
name: fatty-acid--CoA ligase
is described by: ECO:0000269
is: SBO:0000176

metaR LEUKTRD4t
is described by: ECO:0000269
kinetic law: MODEL1310110063#
reactant: MODEL1310110063#
type: Reaction
name: leukotriene D4 transport
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10358072,PMID:12507753,PMID:9334206 NOTES:
reversible: true
product: MODEL1310110063#
fast: false
is: SBO:0000185

metaR EX prostgd2 LPAREN e RPAREN
kinetic law: MODEL1310110063#
reactant: MODEL1310110063#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Prostaglandin D2 exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110063#_68ef12d4_92ac_4c5a_8fa2_277ccbf09f3e
name: ALDH3B1
type: Species
boundary condition: true
is: SBO:0000252
initial amount: NaN
is: P43353
initial concentration: NaN
is encoded by: hsa:221
has only substance units: false
constant: false

metaM tddedi2coa m
boundary condition: false
notes: FORMULA: C33H50N7O17P3S CHARGE: -4
is: C08277
is: SBO:0000247
initial concentration: 1.0
name: trans2,6dodecadienoylcoa
initial amount: NaN
has only substance units: false
is: HMDB00792
type: Species
constant: false

metaR OXAHCOtex
reversible: false
kinetic law: MODEL1310110063#
fast: false
reactant: MODEL1310110063#
is: SBO:0000185
notes: GENE_ASSOCIATION: (1836.1) or (10861.1) or (10861.3) or (10861.2) or (1811.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:12759755 NOTES:SAB
name: oxalate transport via bicarbonate countertransport
product: MODEL1310110063#
type: Reaction
modifier: MODEL1310110063#
is described by: ECO:0000304

metaM dlnlcgcrn c
type: Species
is: CHEBI:16004
constant: false
initial amount: NaN
notes: FORMULA: C27H47NO4 CHARGE: 0 INCHI: InChI=1/C27H47NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-27(31)32-25(23-26(29)30)24-28(2,3)4/h9-10,12-13,15-16,25H,5-8,11,14,17-24H2,1-4H3
is: HMDB01311
name: dihomo-gamma-linolenyl carnitine
initial concentration: 1.0
is: SBO:0000247
has only substance units: false
boundary condition: false

metaR RE3273C
is version of: http://identifiers.org/ec-code/3.1.4.4
reversible: true
type: Reaction
product: MODEL1310110063#
fast: false
reactant: MODEL1310110063#
is: SBO:0000176
name: RE3273
modifier: MODEL1310110063#
notes: GENE_ASSOCIATION: (5338.1) SUBSYSTEM: Phosphatidylinositol phosphate metabolism EC Number: 3.1.4.4 Confidence Level: 0 AUTHORS: PMID:3135804 NOTES:
kinetic law: MODEL1310110063#
is described by: ECO:0000000

metaM stcoa m
initial amount: NaN
type: Species
name: Stearoyl-CoA (n-C18:0CoA)
notes: FORMULA: C39H66N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00338 EHMN_ABBREVIATION: C00412
is: CHEBI:57394
has only substance units: false
boundary condition: false
initial concentration: 1.0
is: SBO:0000247
is: C00412
constant: false
is: HMDB01114

metaR DM gpi sig er
kinetic law: MODEL1310110063#
reactant: MODEL1310110063#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 0 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: false
name: DM gpi sig(er)
type: Reaction

metaR FACOAL1821
reactant: MODEL1310110063#
is: SBO:0000176
fast: false
product: MODEL1310110063#
name: fatty-acid--CoA ligase
is described by: ECO:0000269
modifier: MODEL1310110063#
type: Reaction
is version of: http://identifiers.org/ec-code/6.2.1.3
reversible: true
notes: GENE_ASSOCIATION: (2180.1) SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 4 AUTHORS: PMID:15292367 NOTES:NJ, RE1514C
kinetic law: MODEL1310110063#

metaR XOLTRIOLtm
is: SBO:0000185
product: MODEL1310110063#
is described by: ECO:0000000
kinetic law: MODEL1310110063#
type: Reaction
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: PMID:12840657 NOTES:cholesterol precursor, transport by "diffusion" -> actually beleived to be flip-flop mechanism (PMID: 12840657). NJ
reactant: MODEL1310110063#
name: lipid, flip-flop intracellular transport
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110063#_a60697c3_b58a_49cf_9892_9bc06a89b4e1
constant: false
is encoded by: hsa:6541
has only substance units: false
type: Species
initial amount: NaN
is: P30825
boundary condition: true
is: SBO:0000252
initial concentration: NaN
name: SLC7A1

metaR DIGALSIDEtl
product: MODEL1310110063#
type: Reaction
reversible: true
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 1 AUTHORS: NOTES:unknown mechanism for transport - however must get to other intracellular compartments (e.g. lysosome for degradation) NJ
kinetic law: MODEL1310110063#
fast: false
name: digalside hs intracellular transport
reactant: MODEL1310110063#
is: SBO:0000185

metaM lnlnca e
has only substance units: false
notes: FORMULA: C18H29O2 CHARGE: -1 INCHI: InChI=1S/C18H30O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20/h3-4,6-7,9-10H,2,5,8,11-17H2,1H3,(H,19,20)/p-1/b4-3-,7-6-,10-9-
name: alpha-linolenate
initial concentration: 1.0
type: Species
is: CHEBI:32387
is: SBO:0000247
boundary condition: false
initial amount: NaN
is: HMDB01388
constant: false

metaR DURAD
reactant: MODEL1310110063#
is: SBO:0000176
fast: false
reversible: true
is version of: http://identifiers.org/ec-code/1.3.1.2
type: Reaction
name: dihydrouracil dehydrogenase (NADP)
notes: GENE_ASSOCIATION: (1806.1) SUBSYSTEM: Pyrimidine catabolism EC Number: 1.3.1.2 Confidence Level: 4 AUTHORS: PMID:1512248,PMID:8221682 NOTES:_01-26-05 IT based on Lu et al., JBC,1992,24,17102-17109
kinetic law: MODEL1310110063#
is described by: ECO:0000269
modifier: MODEL1310110063#
product: MODEL1310110063#

http://identifiers.org/biomodels.db/MODEL1310110063#_cbea27e0_9f80_4a01_8f6e_264d0ae67e78
constant: false
is encoded by: hsa:410
initial amount: NaN
type: Species
is: SBO:0000252
initial concentration: NaN
is: P15289
boundary condition: true
name: ARSA
has only substance units: false

metaR AKGMALtm
kinetic law: MODEL1310110063#
is described by: ECO:0000269
name: alpha-ketoglutarate/malate transporter
reversible: true
type: Reaction
product: MODEL1310110063#
is: SBO:0000185
reactant: MODEL1310110063#
notes: GENE_ASSOCIATION: (8402.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172 NOTES:TV
modifier: MODEL1310110063#
fast: false

http://identifiers.org/biomodels.db/MODEL1310110063#_2d45d853_0218_40cc_931e_9981513718a0
has only substance units: false
boundary condition: true
constant: false
is: Q9Y2A9
is: SBO:0000252
is encoded by: hsa:10331
initial concentration: NaN
initial amount: NaN
type: Species
name: B3GNT3

metaR GUAPRT
reactant: MODEL1310110063#
reversible: false
name: guanine phosphoribosyltransferase
type: Reaction
product: MODEL1310110063#
fast: false
kinetic law: MODEL1310110063#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.4.2.8
notes: GENE_ASSOCIATION: (3251.1) SUBSYSTEM: Nucleotide salvage pathway EC Number: 2.4.2.8 Confidence Level: 4 AUTHORS: PMID:3008106,PMID:6853490 NOTES:Guanine and 6-mercaptopurine can replace hypoxanthine EC added (2.4.2.7 makes the same reaction) IT
is described by: ECO:0000269
modifier: MODEL1310110063#

metaR GULN3D
type: Reaction
reversible: true
is described by: ECO:0000000
fast: false
product: MODEL1310110063#
notes: GENE_ASSOCIATION: SUBSYSTEM: Pentose phosphate pathway EC Number: 1.1.1.45 Confidence Level: 2 AUTHORS: PMID:6821187 NOTES:NCD
kinetic law: MODEL1310110063#
name: L-gulonate 3-dehydrogenase
reactant: MODEL1310110063#
is: SBO:0000176

metaM HC02205 c
name: prostaglandin-b2
initial amount: NaN
notes: FORMULA: C20H29O4 CHARGE: -1 INCHI: InChI=1S/C20H30O4/c1-2-3-6-9-17(21)14-12-16-13-15-19(22)18(16)10-7-4-5-8-11-20(23)24/h4,7,12,14,17,21H,2-3,5-6,8-11,13,15H2,1H3,(H,23,24)/b7-4-,14-12+/t17-/m0/s1 EHMN_ABBREVIATION: C05954
has only substance units: false
is: CHEBI:28099
is: SBO:0000247
initial concentration: 1.0
type: Species
boundary condition: false
constant: false

metaR NaKt
modifier: MODEL1310110063#
type: Reaction
is described by: ECO:0000269
reactant: MODEL1310110063#
name: Na+/K+ exchanging ATPase
kinetic law: MODEL1310110063#
fast: false
is version of: http://identifiers.org/ec-code/3.6.3.9
reversible: false
notes: GENE_ASSOCIATION: (481.1 and 478.1) or (477.1 and 23439.1) or (483.1 and 476.1) or (481.1 and 480.1) or (482.1 and 478.1) or (482.1 and 476.1) or (482.1 and 477.1) or (481.1 and 476.1) or (23439.1 and 476.1) or (480.1 and 23439.1) or (481.1 and 477.1) SUBSYSTEM: Transport, extracellular EC Number: 3.6.3.9 Confidence Level: 4 AUTHORS: PMID:10456317,PMID:8833915,PMID:9159180 NOTES:AMF TDV (8/25/2005, stoichiometry changed)
product: MODEL1310110063#
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110063#_fbadcb29_0a6e_4b6b_b74a_4318713d94e6
constant: false
name: LHPP
boundary condition: true
initial amount: NaN
is encoded by: hsa:64077
type: Species
is: SBO:0000252
has only substance units: false
initial concentration: NaN
is: Q9H008

metaR r2384
reactant: MODEL1310110063#
is described by: ECO:0000000
modifier: MODEL1310110063#
kinetic law: MODEL1310110063#
is: SBO:0000185
reversible: false
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
fast: false
product: MODEL1310110063#
type: Reaction
notes: GENE_ASSOCIATION: (215.1) or (U52111.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172 NOTES:

metaR G14T17g
reversible: false
kinetic law: MODEL1310110063#
is version of: http://identifiers.org/ec-code/2.4.1.90
notes: GENE_ASSOCIATION: (8703.1) or (8704.2) or (8704.1) or (2683.1) or (9334.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.38 Confidence Level: 4 AUTHORS: PMID:12512857,PMID:1903938,PMID:3094506,PMID:3144273,PMID:9405390,PMID:9435216 NOTES:Keratan sulfate I biosynthesis NCD
is described by: ECO:0000000
reactant: MODEL1310110063#
modifier: MODEL1310110063#
type: Reaction
product: MODEL1310110063#
name: beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase, Golgi
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.4.1.22
is version of: http://identifiers.org/ec-code/2.4.1.38
fast: false

metaR LGNCt
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11788354,PMID:12864740 NOTES:NJ
fast: false
is: SBO:0000185
reactant: MODEL1310110063#
is described by: ECO:0000000
reversible: true
kinetic law: MODEL1310110063#
name: fatty acid transport via diffusion
product: MODEL1310110063#

http://identifiers.org/biomodels.db/MODEL1310110063#_c1279702_7a39_4405_be6f_6c266f19d7c4
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:5730
initial concentration: NaN
type: Species
is: P41222
has only substance units: false
name: PTGDS
constant: false
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110063#_9530d86b_f21b_4942_a01e_09a1d9e17b27
boundary condition: true
initial amount: NaN
is: SBO:0000252
is: P25325
constant: false
type: Species
has only substance units: false
initial concentration: NaN
is encoded by: hsa:4357
name: MPST

metaR FAOXC227C226m
kinetic law: MODEL1310110063#
product: MODEL1310110063#
reactant: MODEL1310110063#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C22:7-->C22:6)m
type: Reaction

metaM ksii core2 pre6 g
initial concentration: 1.0
constant: false
name: keratan sulfate II biosynthesis, precursor 6
has only substance units: false
is: SBO:0000247
boundary condition: false
initial amount: NaN
type: Species
is: CHEBI:28067
notes: FORMULA: C61H98N5O46SX CHARGE: -2

metaM 1p3h5c m
initial amount: NaN
has only substance units: false
constant: false
initial concentration: 1.0
notes: FORMULA: C5H6NO3 CHARGE: -1 INCHI: InChI=1S/C5H7NO3/c7-3-1-4(5(8)9)6-2-3/h2-4,7H,1H2,(H,8,9)/t3-,4+/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01261 EHMN_ABBREVIATION: C04281
type: Species
name: L-1-Pyrroline-3-hydroxy-5-carboxylate
is: CHEBI:6151
is: HMDB01369
is: SBO:0000247
boundary condition: false

metaR EX dhap LPAREN e RPAREN
kinetic law: MODEL1310110063#
reactant: MODEL1310110063#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of glycerone phosphate(2-)
type: Reaction

metaM xu5p D c
constant: false
has only substance units: false
is: CHEBI:57737
initial concentration: 1.0
type: Species
is: SBO:0000247
notes: FORMULA: C5H9O8P CHARGE: -2 INCHI: InChI=1S/C5H11O8P/c6-1-3(7)5(9)4(8)2-13-14(10,11)12/h4-6,8-9H,1-2H2,(H2,10,11,12)/p-2/t4-,5-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00209
initial amount: NaN
boundary condition: false
is: HMDB00868
name: D-xylulose 5-phosphate(2-)

http://identifiers.org/biomodels.db/MODEL1310110063#_8578bf64_561d_46ba_87b8_12c1565fa378
is: SBO:0000252
boundary condition: true
type: Species
name: ENTPD1
is encoded by: hsa:953
initial amount: NaN
constant: false
initial concentration: NaN
is: Q86VV3
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110063#_d6e0f345_6410_47da_b1bf_74b3bbfe7880
initial concentration: NaN
name: RHBG
is encoded by: hsa:57127
type: Species
has only substance units: false
boundary condition: true
is: Q9H310
constant: false
is: SBO:0000252
initial amount: NaN

metaM ksii core4 pre4 g
has only substance units: false
name: keratan sulfate II biosynthesis, precursor 4
is: SBO:0000247
notes: FORMULA: C61H99N5O43X CHARGE: -1
is: CHEBI:58053
is: C00130
type: Species
constant: false
initial amount: NaN
boundary condition: false
initial concentration: 1.0
is: HMDB00175

http://identifiers.org/biomodels.db/MODEL1310110063#_0c6824b8_787a_480a_965f_bc4002e417a1
name: EPX
is: P11678
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:8288
constant: false
is: SBO:0000252
has only substance units: false
type: Species
boundary condition: true

metaM Tn antigen l
name: Tn antigen
boundary condition: false
initial amount: NaN
has only substance units: false
is: SBO:0000247
type: Species
constant: false
is: C04383
initial concentration: 1.0
notes: FORMULA: C8H14NO5X CHARGE: 0

http://identifiers.org/biomodels.db/MODEL1310110063#_6228610a_3609_47e4_abdc_6ead81611b4d
name: ACSL3
boundary condition: true
is: O95573
initial amount: NaN
has only substance units: false
initial concentration: NaN
constant: false
is: SBO:0000252
is encoded by: hsa:2181
type: Species

metaR r2385
type: Reaction
kinetic law: MODEL1310110063#
is described by: ECO:0000000
reversible: false
fast: false
modifier: MODEL1310110063#
product: MODEL1310110063#
reactant: MODEL1310110063#
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
notes: GENE_ASSOCIATION: (215.1) or (U52111.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172 NOTES:
is: SBO:0000185

metaM 5mta c
boundary condition: false
is: SBO:0000247
notes: FORMULA: C11H15N5O3S CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00165 EHMN_ABBREVIATION: C00170
is: C00170
constant: false
has only substance units: false
is: CHEBI:17509
type: Species
is: HMDB01173
initial concentration: 1.0
initial amount: NaN
name: 5-Methylthioadenosine

metaM C02528 r
boundary condition: false
has only substance units: false
constant: false
is: CHEBI:36234
name: chenodeoxycholate
is: SBO:0000247
notes: FORMULA: C24H39O4 CHARGE: -1 INCHI: InChI=1S/C24H40O4/c1-14(4-7-21(27)28)17-5-6-18-22-19(9-11-24(17,18)3)23(2)10-8-16(25)12-15(23)13-20(22)26/h14-20,22,25-26H,4-13H2,1-3H3,(H,27,28)/p-1/t14-,15+,16-,17-,18+,19+,20-,22+,23+,24-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00958 EHMN_ABBREVIATION: C02528
type: Species
initial amount: NaN
initial concentration: 1.0
is: HMDB00518

metaR DNDPt26m
type: Reaction
is described by: ECO:0000269
kinetic law: MODEL1310110063#
is: SBO:0000185
name: dCDP transport via dUDP antiport
fast: false
notes: GENE_ASSOCIATION: (60386.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:11226231 NOTES:IT
product: MODEL1310110063#
modifier: MODEL1310110063#
reactant: MODEL1310110063#
reversible: false

metaR ENGASEly
type: Reaction
product: MODEL1310110063#
notes: GENE_ASSOCIATION: SUBSYSTEM: N-glycan degradation EC Number: 3.2.1.96 Confidence Level: 0 AUTHORS: NOTES:NCD
is: SBO:0000176
reversible: false
kinetic law: MODEL1310110063#
reactant: MODEL1310110063#
name: endo-beta-N-acetylglucosaminidase, lysosomal
is described by: ECO:0000000
fast: false

metaM amet m
notes: FORMULA: C15H23N6O5S CHARGE: 1 HEPATONET_1.0_ABBREVIATION: HC00029 EHMN_ABBREVIATION: C00019
type: Species
initial concentration: 1.0
boundary condition: false
name: S-Adenosyl-L-methionine
is: SBO:0000247
is: HMDB01185
is: CHEBI:15414
is: C00019
initial amount: NaN
constant: false
has only substance units: false

metaR KSII CORE4tly
type: Reaction
name: keratan sulfate II (core 4) transport, extracellular to lysosome
is: SBO:0000185
reactant: MODEL1310110063#
product: MODEL1310110063#
kinetic law: MODEL1310110063#
fast: false
is described by: ECO:0000000
reversible: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 2 AUTHORS: NOTES:

metaR r0287
notes: GENE_ASSOCIATION: (6576.1) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.16 Confidence Level: 0 AUTHORS: PMID:10806397,PMID:1121274,PMID:1679347,PMID:1735445,PMID:1979337,PMID:2048733,PMID:3194209,PMID:6378901,PMID:8241273 NOTES:
fast: false
modifier: MODEL1310110063#
is described by: ECO:0000000
type: Reaction
name: Acetyl-CoA:acetyl-CoA C-acetyltransferase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:2.3.1.16
product: MODEL1310110063#
reactant: MODEL1310110063#
reversible: false
is: SBO:0000176
kinetic law: MODEL1310110063#

metaR EX fol LPAREN e RPAREN
kinetic law: MODEL1310110063#
reactant: MODEL1310110063#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for Folate
type: Reaction

metaR 10FTHFtm
name: 10-Formyltetrahydrofolate mitochondrial transport via diffusion
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: PMID:11375437 NOTES:NCD
reactant: MODEL1310110063#
product: MODEL1310110063#
type: Reaction
is: SBO:0000185
kinetic law: MODEL1310110063#
reversible: true
fast: false
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110063#_a298796e_a5d1_4504_a043_31898f34e37c
boundary condition: true
type: Species
is encoded by: hsa:4200
is: SBO:0000252
constant: false
name: ME2
is: P23368
initial concentration: NaN
initial amount: NaN
has only substance units: false

metaR RE1807C
reactant: MODEL1310110063#
reversible: true
product: MODEL1310110063#
name: RE1807
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Bile acid synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:9660774 NOTES:
kinetic law: MODEL1310110063#
fast: false
type: Reaction
is: SBO:0000176

metaM glu L e
name: L-glutamate(1-)
is: HMDB00148
initial amount: NaN
type: Species
is: CHEBI:29985
constant: false
is: SBO:0000247
has only substance units: false
initial concentration: 1.0
boundary condition: false
notes: FORMULA: C5H8NO4 CHARGE: -1 INCHI: InChI=1S/C5H9NO4/c6-3(5(9)10)1-2-4(7)8/h3H,1-2,6H2,(H,7,8)(H,9,10)/p-1/t3-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00034 EHMN_ABBREVIATION: C00025

http://identifiers.org/biomodels.db/MODEL1310110063#_e6fc2145_b38f_42aa_b359_a1afbb0bea12
constant: false
is encoded by: hsa:160851
initial amount: NaN
type: Species
initial concentration: NaN
has only substance units: false
name: DGKH
is: Q86XP1
is: SBO:0000252
boundary condition: true

metaM 4h2oglt m
has only substance units: false
is: HMDB02070
constant: false
is: CHEBI:17742
notes: FORMULA: C5H4O6 CHARGE: -2 INCHI: InChI=1S/C5H6O6/c6-2(4(8)9)1-3(7)5(10)11/h2,6H,1H2,(H,8,9)(H,10,11)/p-2
initial concentration: 1.0
initial amount: NaN
is: SBO:0000247
name: 4-hydroxy-2-oxoglutarate(2-)
boundary condition: false
type: Species

metaM cs a deg5 l
is: SBO:0000247
constant: false
boundary condition: false
has only substance units: false
name: chondroitin sulfate A (GalNAc4S-GlcA), degradation product 5
type: Species
initial concentration: 1.0
notes: FORMULA: C23H36O24S CHARGE: -2
initial amount: NaN
is: CHEBI:15936

metaR P450SCC1m
kinetic law: MODEL1310110063#
product: MODEL1310110063#
notes: GENE_ASSOCIATION: SUBSYSTEM: Cholesterol metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:1525048 NOTES:Acting on paired donors with incorporation of molecular oxygen With a reduced iron-sulfur protein as one donor, and incorporation of one atom of oxygen
is: SBO:0000176
is described by: ECO:0000134
fast: false
type: Reaction
reactant: MODEL1310110063#
name: cholesterol monooxygenase
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110063#_b0847bd0_b654_4fc1_ab92_a145bfbf3641
is encoded by: hsa:5279
initial concentration: NaN
has part: Q9BRB3
is encoded by: hsa:5283
boundary condition: true
is encoded by: hsa:5277
has part: Q14442
has part: Q92535
is encoded by: hsa:8818
name: PIGP:PIGA:PIGC:PIGH:DPM2:PIGQ
has part: O94777
type: Species
constant: false
is encoded by: hsa:9091
has part: B3KUV7
initial amount: NaN
has only substance units: false
is: SBO:0000297
is encoded by: hsa:51227

metaM glyc e
is: CHEBI:17754
notes: FORMULA: C3H8O3 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00114 EHMN_ABBREVIATION: C00116
is: SBO:0000247
has only substance units: false
boundary condition: false
type: Species
constant: false
is: C00116
initial concentration: 1.0
is: HMDB00131
name: Glycerol
initial amount: NaN

metaR r1670
name: Y+LAT2 Utilized transport
kinetic law: MODEL1310110063#
modifier: MODEL1310110063#
reversible: true
is described by: ECO:0000000
fast: false
type: Reaction
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is: SBO:0000185
product: MODEL1310110063#
reactant: MODEL1310110063#

metaM k e
name: potassium
is: SBO:0000247
boundary condition: false
initial concentration: 1.0
notes: FORMULA: K CHARGE: 1 HEPATONET_1.0_ABBREVIATION: HC00216 EHMN_ABBREVIATION: C00238
initial amount: NaN
is: HMDB00586
is: C00238
is: CHEBI:29103
type: Species
constant: false
has only substance units: false

metaR RE1573M
kinetic law: MODEL1310110063#
product: MODEL1310110063#
name: RE1573
is version of: http://identifiers.org/ec-code/5.3.3.8
is: SBO:0000176
type: Reaction
is described by: ECO:0000000
modifier: MODEL1310110063#
is version of: http://identifiers.org/ec-code/1.1.1.35
notes: GENE_ASSOCIATION: (1632.1) or (10455.1) or (1962.1) SUBSYSTEM: Fatty acid oxidation EC Number: 5.3.3.8 Confidence Level: 0 AUTHORS: PMID:10407780 NOTES:
fast: false
reactant: MODEL1310110063#
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110063#_c3cb43f2_299a_4aaf_a385_2266104e98de
initial concentration: NaN
name: NDUFS4
type: Species
initial amount: NaN
is: SBO:0000252
is: O43181
has only substance units: false
boundary condition: true
is encoded by: hsa:4724
constant: false

metaM CE4792 m
initial amount: NaN
has only substance units: false
boundary condition: false
constant: false
name: 3-oxo-cis-8-tetradecenoyl-CoA
initial concentration: 1.0
is: SBO:0000247
type: Species
notes: FORMULA: C35H54N7O18P3S CHARGE: -4 INCHI: InChI=1/C35H58N7O18P3S/c1-4-5-6-7-8-9-10-11-12-13-23(43)18-26(45)64-17-16-37-25(44)14-15-38-33(48)30(47)35(2,3)20-57-63(54,55)60-62(52,53)56-19-24-29(59-61(49,50)51)28(46)34(58-24)42-22-41-27-31(36)39-21-40-32(27)42/h8-9,21-22,24,28-30,34,46-47H,4-7,10-20H2,1-3H3,(H,37,44)(H,38,48)(H,52,53)(H,54,55)(H2,36,39,40)(H2,49,50,51)/p-4/b9-8-/t24-,28+,29+,30u,34-/m0/s1 EHMN_ABBREVIATION: CE4792
is: CHEBI:57923

metaR GLAl
modifier: MODEL1310110063#
name: galactosidase, alpha
fast: false
is version of: http://identifiers.org/ec-code/3.2.1.22
product: MODEL1310110063#
kinetic law: MODEL1310110063#
notes: GENE_ASSOCIATION: (2717.1) SUBSYSTEM: Sphingolipid metabolism EC Number: 3.2.1.22 Confidence Level: 4 AUTHORS: PMID:11775551,PMID:11828341,PMID:15003450,PMID:2836863 NOTES:NJ
reversible: false
is: SBO:0000176
is described by: ECO:0000000
reactant: MODEL1310110063#
type: Reaction

metaR EX pan4p LPAREN e RPAREN
kinetic law: MODEL1310110063#
reactant: MODEL1310110063#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for pan4p
type: Reaction

metaR AG13T2g
modifier: MODEL1310110063#
name: N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase, Golgi apparatus
type: Reaction
is: SBO:0000176
reversible: false
product: MODEL1310110063#
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/2.4.1.149
notes: GENE_ASSOCIATION: (79369.1) or (374907.1) or (11041.1) or (146712.1) or (374907.2) or (93010.1) or (10331.1) or (10678.1) or (10678.2) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.149 Confidence Level: 4 AUTHORS: PMID:10747980,PMID:11042166,PMID:12061784,PMID:12512857,PMID:15560372,PMID:15620693,PMID:9405606 NOTES:NCD
fast: false
reactant: MODEL1310110063#
kinetic law: MODEL1310110063#

metaR DURIK1
reactant: MODEL1310110063#
name: deoxyuridine kinase (ATP:Deoxyuridine)
is described by: ECO:0000254
kinetic law: MODEL1310110063#
fast: false
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.7.1.21
reversible: false
modifier: MODEL1310110063#
type: Reaction
product: MODEL1310110063#
notes: GENE_ASSOCIATION: (7083.1) or (7084.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.1.21 Confidence Level: 2 AUTHORS: PMID:12535661,PMID:9342341 NOTES:

metaM ksi deg19 l
has only substance units: false
initial amount: NaN
boundary condition: false
is: HMDB01354
is: SBO:0000247
name: keratan sulfate I, degradation product 19
initial concentration: 1.0
notes: FORMULA: C146H236N10O124S6 CHARGE: -6
is: CHEBI:57455
type: Species
constant: false

metaM 56dthm c
initial amount: NaN
type: Species
boundary condition: false
is: SBO:0000247
notes: FORMULA: C5H8N2O2 CHARGE: 0 INCHI: InChI=1S/C5H8N2O2/c1-3-2-6-5(9)7-4(3)8/h3H,2H2,1H3,(H2,6,7,8,9) HEPATONET_1.0_ABBREVIATION: HC00582 EHMN_ABBREVIATION: C00906
constant: false
is: CHEBI:27468
name: 5,6-dihydrothymine
has only substance units: false
initial concentration: 1.0
is: HMDB00079

metaM cspg b l
is: CHEBI:36005
initial concentration: 1.0
initial amount: NaN
has only substance units: false
name: chondroitin sulfate B / dermatan sulfate (IdoA2S-GalNAc4S) proteoglycan
constant: false
type: Species
notes: FORMULA: C45H65N2O48S4X CHARGE: -6
is: HMDB02183
boundary condition: false
is: SBO:0000247

metaR MCLOR
is version of: http://identifiers.org/ec-code/1.1.1.27
fast: false
is: SBO:0000176
product: MODEL1310110063#
kinetic law: MODEL1310110063#
reactant: MODEL1310110063#
modifier: MODEL1310110063#
name: 3-Mercaptolactate:NAD+ oxidoreductase
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (92483.1) or (3945.1 and 3939.1) or (55293.1) or (3948.2) or (3948.1) or (3945.1) or (160287.1) or (3939.1) SUBSYSTEM: Methionine and cysteine metabolism EC Number: 1.1.1.27 Confidence Level: 4 AUTHORS: PMID:7054184 NOTES:
reversible: true
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110063#_abc0cce0_b510_45bb_9942_550671b77adb
constant: false
is: SBO:0000252
boundary condition: true
is encoded by: hsa:10568
is: O95436
type: Species
has only substance units: false
name: SLC34A2
initial concentration: NaN
initial amount: NaN

metaM glu L c
is: HMDB00148
type: Species
is: CHEBI:29985
boundary condition: false
notes: FORMULA: C5H8NO4 CHARGE: -1 INCHI: InChI=1S/C5H9NO4/c6-3(5(9)10)1-2-4(7)8/h3H,1-2,6H2,(H,7,8)(H,9,10)/p-1/t3-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00034 EHMN_ABBREVIATION: C00025
name: L-glutamate(1-)
constant: false
is: SBO:0000247
initial amount: NaN
initial concentration: 1.0
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110063#_e4b6e1de_a19d_47f2_b9e6_1ea1135bd27e
initial concentration: NaN
boundary condition: true
type: Species
name: NADSYN1
initial amount: NaN
is encoded by: hsa:55191
has only substance units: false
constant: false
is: SBO:0000252
is: Q6IA69

http://identifiers.org/biomodels.db/MODEL1310110063#_a075a62b_de02_46bf_b113_e4599d81522c
boundary condition: true
is: SBO:0000252
initial amount: NaN
name: AK7
is: Q96M32
initial concentration: NaN
constant: false
type: Species
is encoded by: hsa:122481
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110063#_d622166b_7828_45d5_8142_224f0509d6c3
is encoded by: hsa:4694
initial amount: NaN
is: SBO:0000252
constant: false
name: NDUFA1
has only substance units: false
initial concentration: NaN
is: Q6IBB5
boundary condition: true
type: Species

metaM ptrc e
type: Species
boundary condition: false
name: Putrescine
is: CHEBI:326268
initial amount: NaN
constant: false
is: C00134
notes: FORMULA: C4H14N2 CHARGE: 2 HEPATONET_1.0_ABBREVIATION: HC00132 EHMN_ABBREVIATION: C00134
is: HMDB01414
is: SBO:0000247
initial concentration: 1.0
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110063#_d8c19903_4132_4e1f_a226_8503542921da
boundary condition: true
is encoded by: hsa:125206
initial amount: NaN
constant: false
has only substance units: false
initial concentration: NaN
is: A0PJK1
type: Species
is: SBO:0000252
name: SLC5A10

http://identifiers.org/biomodels.db/MODEL1310110063#_dbf41372_1d64_4edc_add7_62566b8f4cf9
is: SBO:0000252
initial amount: NaN
constant: false
is encoded by: hsa:84569
name: LYZL1
is: Q6UWQ5
has only substance units: false
initial concentration: NaN
type: Species
boundary condition: true

metaR PPCDC
reactant: MODEL1310110063#
product: MODEL1310110063#
reversible: false
is: SBO:0000176
name: phosphopantothenoylcysteine decarboxylase
fast: false
is version of: http://identifiers.org/ec-code/4.1.1.36
notes: GENE_ASSOCIATION: (60490.1) SUBSYSTEM: CoA synthesis EC Number: 4.1.1.36 Confidence Level: 4 AUTHORS: PMID:11923312 NOTES:
is described by: ECO:0000269
modifier: MODEL1310110063#
type: Reaction
kinetic law: MODEL1310110063#

metaR EX hdca LPAREN e RPAREN
kinetic law: MODEL1310110063#
reactant: MODEL1310110063#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Hexadecanoate (n-C16:0) exchange
type: Reaction

metaM dmnoncoa x
initial concentration: 1.0
type: Species
boundary condition: false
initial amount: NaN
name: 4,8 dimethylnonanoyl-CoA
is: HMDB11604
has only substance units: false
is: SBO:0000247
constant: false
notes: FORMULA: C32H54N7O17P3S CHARGE: -4 INCHI: InChI=1/C32H56N7O17P3S/c1-19(2)7-6-8-20(3)9-10-23(41)60-14-13-34-22(40)11-12-35-30(44)27(43)32(4,5)16-53-59(50,51)56-58(48,49)52-15-21-26(55-57(45,46)47)25(42)31(54-21)39-18-38-24-28(33)36-17-37-29(24)39/h17-21,25-27,31,42-43H,6-16H2,1-5H3,(H,34,40)(H,35,44)(H,48,49)(H,50,51)(H2,33,36,37)(H2,45,46,47)/t20?,21-,25-,26-,27?,31-/m1/s1

metaR FE2t
product: MODEL1310110063#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12440707 NOTES:
reversible: false
is: SBO:0000185
name: iron (II) transport
is described by: ECO:0000000
reactant: MODEL1310110063#
kinetic law: MODEL1310110063#
fast: false

metaM 4abut e
constant: false
is: HMDB00112
is: C00334
has only substance units: false
name: 4-Aminobutanoate
type: Species
initial amount: NaN
initial concentration: 1.0
boundary condition: false
notes: FORMULA: C4H9NO2 CHARGE: 0
is: CHEBI:3628
is: SBO:0000247

metaR CERT2gt
modifier: MODEL1310110063#
reversible: true
notes: GENE_ASSOCIATION: (10087.1) SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 2 AUTHORS: PMID:12803919,PMID:14685229,PMID:15596449,PMID:15907394 NOTES:non-vesicular intracellular transport of glucocerebroside
kinetic law: MODEL1310110063#
reactant: MODEL1310110063#
is: SBO:0000185
fast: false
is described by: ECO:0000000
type: Reaction
name: ceramide transport protein
product: MODEL1310110063#
is version of: http://identifiers.org/ec-code/2.7.11.1

metaM q10h2 c
name: Ubiquinol-10
initial amount: NaN
has only substance units: false
initial concentration: 1.0
is: http://identifiers.org/pubchem.compound/6504740
boundary condition: false
is: HMDB13111
notes: FORMULA: C59H92O4 CHARGE: 0 INCHI: InChI=1/C59H92O4/c1-44(2)24-15-25-45(3)26-16-27-46(4)28-17-29-47(5)30-18-31-48(6)32-19-33-49(7)34-20-35-50(8)36-21-37-51(9)38-22-39-52(10)40-23-41-53(11)42-43-55-54(12)56(60)58(62-13)59(63-14)57(55)61/h24,26,28,30,32,34,36,38,40,42,60-61H,15-23,25,27,29,31,33,35,37,39,41,43H2,1-14H3/b45-26+,46-28+,47-30+,48-32+,49-34+,50-36+,51-38+,52-40+,53-42+ HEPATONET_1.0_ABBREVIATION: HC00324
constant: false
is: SBO:0000247
type: Species

http://identifiers.org/biomodels.db/MODEL1310110063#_ef8e776a_7bc3_4341_a307_99b1da66a932
is: Q9BZ23
boundary condition: true
constant: false
is encoded by: hsa:80025
type: Species
is: SBO:0000252
initial concentration: NaN
has only substance units: false
name: PANK2
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110063#_4f240b9d_0887_4e50_beae_5a81eff5ee16
boundary condition: true
is encoded by: hsa:1629
name: DBT
is: SBO:0000252
has only substance units: false
type: Species
initial concentration: NaN
constant: false
initial amount: NaN
is: P11182

metaM gly m
constant: false
is: HMDB00123
notes: FORMULA: C2H5NO2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00045 EHMN_ABBREVIATION: C00037
name: Glycine
has only substance units: false
is: CHEBI:15428
is: C00037
initial concentration: 1.0
initial amount: NaN
is: SBO:0000247
type: Species
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110063#_ab0a2796_7465_44d2_ab91_b6080f41e5e8
is: Q6LEN6
boundary condition: true
constant: false
initial concentration: NaN
type: Species
is encoded by: hsa:1103
initial amount: NaN
has only substance units: false
name: CHAT
is: SBO:0000252

metaR AHEXASEly
type: Reaction
kinetic law: MODEL1310110063#
notes: GENE_ASSOCIATION: (3073.1) or (3074.1) or (3073.1 and 3074.1) SUBSYSTEM: N-glycan degradation EC Number: 3.2.1.52 Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12706724 NOTES:NCD
is: SBO:0000176
product: MODEL1310110063#
reversible: false
is version of: http://identifiers.org/ec-code/3.2.1.52
name: beta-N-acetylhexosaminidase, lysosomal
fast: false
is described by: ECO:0000000
reactant: MODEL1310110063#
modifier: MODEL1310110063#

metaM s2l2n2m2masn l
boundary condition: false
is: CHEBI:18287
initial concentration: 1.0
is: HMDB00174
name: de-Fuc form of PA6
notes: FORMULA: C84H135N6O61X CHARGE: -2
is: SBO:0000247
initial amount: NaN
constant: false
type: Species
has only substance units: false

metaM xoltriol m
type: Species
initial amount: NaN
initial concentration: 1.0
constant: false
has only substance units: false
boundary condition: false
notes: FORMULA: C27H48O3 CHARGE: 0 INCHI: InChI=1S/C27H48O3/c1-16(2)7-6-8-17(3)20-9-10-21-25-22(15-24(30)27(20,21)5)26(4)12-11-19(28)13-18(26)14-23(25)29/h16-25,28-30H,6-15H2,1-5H3/t17-,18+,19-,20-,21+,22+,23-,24+,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01463 EHMN_ABBREVIATION: C05454
name: 5beta-cholestane-3alpha,7alpha,12alpha-triol
is: SBO:0000247
is: CHEBI:16496
is: HMDB01457

http://identifiers.org/biomodels.db/MODEL1310110063#_33d1c0bb_0ac8_481d_860f_7213c85c5d98
is: Q9GZX3
initial amount: NaN
initial concentration: NaN
is: SBO:0000252
boundary condition: true
type: Species
name: CHST6
is encoded by: hsa:4166
constant: false
has only substance units: false

metaR r2055
is described by: ECO:0000000
reversible: false
fast: false
type: Reaction
product: MODEL1310110063#
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.15
is: SBO:0000185
reactant: MODEL1310110063#
modifier: MODEL1310110063#
kinetic law: MODEL1310110063#

metaM ptrc c
is: C00134
initial concentration: 1.0
notes: FORMULA: C4H14N2 CHARGE: 2 HEPATONET_1.0_ABBREVIATION: HC00132 EHMN_ABBREVIATION: C00134
is: SBO:0000247
type: Species
initial amount: NaN
constant: false
is: HMDB01414
boundary condition: false
is: CHEBI:326268
name: Putrescine
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110063#_541063f5_6e24_4545_85a0_b1cbbcde88d6
has only substance units: false
initial concentration: NaN
boundary condition: true
constant: false
type: Species
is encoded by: hsa:2584
is: P51570
name: GALK1
initial amount: NaN
is: SBO:0000252

metaR r1671
is described by: ECO:0000000
modifier: MODEL1310110063#
product: MODEL1310110063#
type: Reaction
reactant: MODEL1310110063#
kinetic law: MODEL1310110063#
fast: false
is: SBO:0000185
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
name: Y+LAT2 Utilized transport
reversible: true

metaM 2mop c
is: HMDB01172
name: 2-methyl-3-oxopropanoate
is: SBO:0000247
initial concentration: 1.0
notes: FORMULA: C4H5O3 CHARGE: -1 INCHI: InChI=1S/C4H6O3/c1-3(2-5)4(6)7/h2-3H,1H3,(H,6,7)/p-1 HEPATONET_1.0_ABBREVIATION: HC00296 EHMN_ABBREVIATION: C00349
initial amount: NaN
type: Species
boundary condition: false
is: CHEBI:57700
has only substance units: false
constant: false

metaR ETFQO
is: SBO:0000176
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (2110.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.5.5.1 Confidence Level: 4 AUTHORS: PMID:10444348,PMID:12049629 NOTES:TV Ruzicka F, JBC, 1977
kinetic law: MODEL1310110063#
name: Electron transfer flavoprotein-ubiquinone oxidoreductase
is version of: http://identifiers.org/ec-code/1.5.5.1
reversible: false
product: MODEL1310110063#
modifier: MODEL1310110063#
fast: false
type: Reaction
reactant: MODEL1310110063#

metaR PHYHx
type: Reaction
modifier: MODEL1310110063#
notes: GENE_ASSOCIATION: (5264.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.14.11.18 Confidence Level: 4 AUTHORS: PMID:8954107,PMID:9326940 NOTES:NJ
reactant: MODEL1310110063#
is version of: http://identifiers.org/ec-code/1.14.11.18
is described by: ECO:0000269
product: MODEL1310110063#
fast: false
name: Phytanoyl-CoA dioxygenase, peroxisomal
kinetic law: MODEL1310110063#
is: SBO:0000176
reversible: false

metaM prostgd2 e
initial concentration: 1.0
initial amount: NaN
is: HMDB01403
type: Species
boundary condition: false
is: SBO:0000247
constant: false
notes: FORMULA: C20H31O5 CHARGE: -1 INCHI: InChI=1S/C20H32O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h4,7,12-13,15-18,21-22H,2-3,5-6,8-11,14H2,1H3,(H,24,25)/p-1/b7-4-,13-12+/t15-,16+,17+,18-/m0/s1 EHMN_ABBREVIATION: C00696
is: CHEBI:57406
has only substance units: false
name: prostaglandin D2(1-)

metaR NDP8
is: SBO:0000176
reversible: false
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/2.7.4.9
name: nucleoside-diphosphatase (dUDP)
reactant: MODEL1310110063#
product: MODEL1310110063#
type: Reaction
kinetic law: MODEL1310110063#
notes: GENE_ASSOCIATION: (1841.1) SUBSYSTEM: Nucleotide interconversion EC Number: 3.6.1.6 Confidence Level: 4 AUTHORS: NOTES:
fast: false
modifier: MODEL1310110063#

metaR FAOXC103C102x
kinetic law: MODEL1310110063#
product: MODEL1310110063#
reactant: MODEL1310110063#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C10:3-->C10:2)x
type: Reaction

metaM xol7aone r
constant: false
notes: FORMULA: C27H44O2 CHARGE: 0 INCHI: InChI=1S/C27H44O2/c1-17(2)7-6-8-18(3)21-9-10-22-25-23(12-14-27(21,22)5)26(4)13-11-20(28)15-19(26)16-24(25)29/h15,17-18,21-25,29H,6-14,16H2,1-5H3/t18-,21-,22+,23+,24-,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01464 EHMN_ABBREVIATION: C05455
is: CHEBI:17899
is: SBO:0000247
initial concentration: 1.0
name: 7alpha-hydroxycholest-4-en-3-one
boundary condition: false
has only substance units: false
is: HMDB01993
initial amount: NaN
type: Species

metaR G3PD1
fast: false
reversible: true
name: glycerol-3-phosphate dehydrogenase (NAD)
product: MODEL1310110063#
is version of: http://identifiers.org/ec-code/1.1.1.8
reactant: MODEL1310110063#
modifier: MODEL1310110063#
type: Reaction
kinetic law: MODEL1310110063#
is: SBO:0000176
notes: GENE_ASSOCIATION: (2819.1) SUBSYSTEM: Glycerophospholipid metabolism EC Number: 1.1.1.94 Confidence Level: 4 AUTHORS: PMID:11385633,PMID:7772607 NOTES:NAD-specific; see also G3PD2
is described by: ECO:0000269

metaR PSt3
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: 2.7.8.8 Confidence Level: 2 AUTHORS: NOTES:
is described by: ECO:0000269
reactant: MODEL1310110063#
is: SBO:0000185
product: MODEL1310110063#
type: Reaction
fast: false
reversible: true
name: phosphatidylserine transport
kinetic law: MODEL1310110063#

http://identifiers.org/biomodels.db/MODEL1310110063#_bb7f22f4_53cd_4f92_9f75_d6e35971c257
is: SBO:0000252
constant: false
is encoded by: hsa:AI222095
name: _AI222095_1_m
type: Species
boundary condition: true
initial concentration: NaN
initial amount: NaN
has only substance units: false

metaR HDCAtr
is described by: ECO:0000000
name: fatty acid transport via diffusion
reactant: MODEL1310110063#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11788354,PMID:12864740 NOTES:NJ
reversible: true
type: Reaction
fast: false
is: SBO:0000185
product: MODEL1310110063#
kinetic law: MODEL1310110063#

metaR PI34P5K
notes: GENE_ASSOCIATION: (8394.1) or (23396.1) or (8395.1) SUBSYSTEM: Inositol phosphate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:10358929,PMID:1850246,PMID:1851250,PMID:2174884,PMID:8042983 NOTES:NCD
name: phosphatidylinositol 3,4-bisphosphate 5-kinase
product: MODEL1310110063#
is described by: ECO:0000000
modifier: MODEL1310110063#
reactant: MODEL1310110063#
type: Reaction
reversible: false
is: SBO:0000176
fast: false
kinetic law: MODEL1310110063#
is version of: http://identifiers.org/ec-code/2.7.1.68

metaM 4abut c
has only substance units: false
name: 4-Aminobutanoate
constant: false
is: HMDB00112
initial concentration: 1.0
is: C00334
boundary condition: false
initial amount: NaN
type: Species
notes: FORMULA: C4H9NO2 CHARGE: 0
is: CHEBI:3628
is: SBO:0000247

metaR NRPPHRSULT
reactant: MODEL1310110063#
reversible: false
name: Norepinephrine Sulfotransferase
is version of: http://identifiers.org/ec-code/2.8.2.1
modifier: MODEL1310110063#
fast: false
product: MODEL1310110063#
is: SBO:0000176
notes: GENE_ASSOCIATION: (6818.1) or (6818.3) or (6818.2) SUBSYSTEM: Tyrosine metabolism EC Number: 2.8.2.1 Confidence Level: 4 AUTHORS: PMID:11535246,PMID:15293241 NOTES:RS/TV (6/14/05)
type: Reaction
is described by: ECO:0000269
kinetic law: MODEL1310110063#

metaR r0570
name: 2-Deoxy-D-ribose 1-phosphate 1,5-phosphomutase Pentose phosphate pathway EC:5.4.2.7
reversible: true
modifier: MODEL1310110063#
fast: false
reactant: MODEL1310110063#
is described by: ECO:0000000
is: SBO:0000176
kinetic law: MODEL1310110063#
product: MODEL1310110063#
notes: GENE_ASSOCIATION: (10588.1) or (400410.1) SUBSYSTEM: Pentose phosphate pathway EC Number: 5.4.2.7 Confidence Level: 0 AUTHORS: PMID:3023765 NOTES:
type: Reaction
is version of: http://identifiers.org/ec-code/6.3.3.2

metaM dlnlcgcrn m
is: CHEBI:16004
initial amount: NaN
is: SBO:0000247
has only substance units: false
notes: FORMULA: C27H47NO4 CHARGE: 0 INCHI: InChI=1/C27H47NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-27(31)32-25(23-26(29)30)24-28(2,3)4/h9-10,12-13,15-16,25H,5-8,11,14,17-24H2,1-4H3
initial concentration: 1.0
constant: false
is: HMDB01311
name: dihomo-gamma-linolenyl carnitine
type: Species
boundary condition: false

metaM q10h2 e
type: Species
constant: false
boundary condition: false
is: SBO:0000247
initial concentration: 1.0
is: http://identifiers.org/pubchem.compound/6504740
has only substance units: false
initial amount: NaN
name: Ubiquinol-10
is: HMDB13111
notes: FORMULA: C59H92O4 CHARGE: 0 INCHI: InChI=1/C59H92O4/c1-44(2)24-15-25-45(3)26-16-27-46(4)28-17-29-47(5)30-18-31-48(6)32-19-33-49(7)34-20-35-50(8)36-21-37-51(9)38-22-39-52(10)40-23-41-53(11)42-43-55-54(12)56(60)58(62-13)59(63-14)57(55)61/h24,26,28,30,32,34,36,38,40,42,60-61H,15-23,25,27,29,31,33,35,37,39,41,43H2,1-14H3/b45-26+,46-28+,47-30+,48-32+,49-34+,50-36+,51-38+,52-40+,53-42+

metaM 3ivcoa c
notes: FORMULA: C26H40N7O18P3S CHARGE: -4
is: HMDB06870
is: SBO:0000247
has only substance units: false
is: C05998
constant: false
initial amount: NaN
name: 3-hydroxyisovalerylcoa
initial concentration: 1.0
is: http://identifiers.org/pubchem.compound/11966188
boundary condition: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110063#_a7fda765_3789_4e2a_af36_32b3c0d061d6
boundary condition: true
is encoded by: hsa:1608
type: Species
constant: false
is: P49619
initial amount: NaN
is: SBO:0000252
name: DGKG
initial concentration: NaN
has only substance units: false

metaM HC02149 m
boundary condition: false
is: CHEBI:28867
notes: FORMULA: C10H19NO4 CHARGE: 0 INCHI: InChI=1S/C10H19NO4/c1-5-10(14)15-8(6-9(12)13)7-11(2,3)4/h8H,5-7H2,1-4H3
type: Species
has only substance units: false
initial amount: NaN
initial concentration: 1.0
name: O-Propanoylcarnitine
is: SBO:0000247
constant: false

metaR r0426
modifier: MODEL1310110063#
is described by: ECO:0000000
is: SBO:0000176
notes: GENE_ASSOCIATION: (5860.1) SUBSYSTEM: Unassigned EC Number: 4.2.1.3 Confidence Level: 0 AUTHORS: PMID:15263083,PMID:16511074 NOTES:
fast: false
kinetic law: MODEL1310110063#
reactant: MODEL1310110063#
is version of: http://identifiers.org/ec-code/1.5.1.34
name: isocitrate hydro-lyase Citrate cycle (TCA cycle) / Glyoxylate and dicarboxylate metabolism EC:4.2.1.3
type: Reaction
reversible: true
product: MODEL1310110063#

http://identifiers.org/biomodels.db/MODEL1310110063#_539f673b_4066_4de2_8087_a5500ee11b30
type: Species
is encoded by: hsa:8659
is: SBO:0000252
name: ALDH4A1
initial amount: NaN
initial concentration: NaN
constant: false
boundary condition: true
has only substance units: false

metaM CE5161 r
initial amount: NaN
initial concentration: 1.0
boundary condition: false
type: Species
constant: false
name: 3(S)-hydroxy-cis-9-octadecenoyl-CoA
notes: FORMULA: C39H64N7O18P3S CHARGE: -4 INCHI: InChI=1/C39H68N7O18P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-27(47)22-30(49)68-21-20-41-29(48)18-19-42-37(52)34(51)39(2,3)24-61-67(58,59)64-66(56,57)60-23-28-33(63-65(53,54)55)32(50)38(62-28)46-26-45-31-35(40)43-25-44-36(31)46/h11-12,25-28,32-34,38,47,50-51H,4-10,13-24H2,1-3H3,(H,41,48)(H,42,52)(H,56,57)(H,58,59)(H2,40,43,44)(H2,53,54,55)/p-4/b12-11-/t27-,28-,32+,33+,34u,38-/m0/s1 EHMN_ABBREVIATION: CE5161
has only substance units: false
is: CHEBI:57923
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110063#_0cccfd26_db6a_4f93_ac05_78da80a38c80
has only substance units: false
constant: false
initial amount: NaN
is: Q6FHI7
is: SBO:0000252
type: Species
name: CA4
is encoded by: hsa:762
boundary condition: true
initial concentration: NaN

metaM 2dp6mobq m
has only substance units: false
name: 2-decaprenyl-6-methoxy-1,4-benzoquinone
boundary condition: false
is: SBO:0000247
initial amount: NaN
initial concentration: 1.0
notes: FORMULA: C57H86O3 CHARGE: 0 INCHI: InChI=1S/C57H86O3/c1-44(2)22-13-23-45(3)24-14-25-46(4)26-15-27-47(5)28-16-29-48(6)30-17-31-49(7)32-18-33-50(8)34-19-35-51(9)36-20-37-52(10)38-21-39-53(11)40-41-54-42-55(58)43-56(60-12)57(54)59/h22,24,26,28,30,32,34,36,38,40,42-43H,13-21,23,25,27,29,31,33,35,37,39,41H2,1-12H3/b45-24+,46-26+,47-28+,48-30+,49-32+,50-34+,51-36+,52-38+,53-40+
constant: false
type: Species
is: CHEBI:50773

metaR r0571
is described by: ECO:0000000
is: SBO:0000176
notes: GENE_ASSOCIATION: (10157.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 3.1.2.17 Confidence Level: 0 AUTHORS: PMID:3071714,PMID:6885824 NOTES:
name: (S)-Methylmalonyl-CoA hydrolase Propanoate metabolism EC:3.1.2.17
is version of: http://identifiers.org/ec-code/1.5.1.8
type: Reaction
fast: false
reactant: MODEL1310110063#
kinetic law: MODEL1310110063#
product: MODEL1310110063#
reversible: true
modifier: MODEL1310110063#

metaR GALK
reversible: false
type: Reaction
notes: GENE_ASSOCIATION: (2584.1) or (2585.2) or (2585.1) SUBSYSTEM: Galactose metabolism EC Number: 2.7.1.6 Confidence Level: 0 AUTHORS: PMID:4371022 NOTES:INVALID ECO TERM: IFH
reactant: MODEL1310110063#
is version of: http://identifiers.org/ec-code/2.7.1.157
is version of: http://identifiers.org/ec-code/2.7.1.6
modifier: MODEL1310110063#
fast: false
kinetic law: MODEL1310110063#
product: MODEL1310110063#
is: SBO:0000176
name: galactokinase
is described by: ECO:0000000

metaR DHEASULT
kinetic law: MODEL1310110063#
is described by: ECO:0000269
fast: false
notes: GENE_ASSOCIATION: (6783.1) or (6822.1) SUBSYSTEM: Steroid metabolism EC Number: 2.8.2.2 Confidence Level: 4 AUTHORS: PMID:11535246,PMID:1588921 NOTES:NJ
is version of: http://identifiers.org/ec-code/2.8.2.14
name: Dehydroepiandrosterone sulfotransferase
product: MODEL1310110063#
reversible: false
is version of: http://identifiers.org/ec-code/2.8.2.4
is: SBO:0000176
modifier: MODEL1310110063#
reactant: MODEL1310110063#
type: Reaction

metaR r0423
reversible: true
is described by: ECO:0000000
reactant: MODEL1310110063#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.2.1.3
name: Isocitrate:NADP+ oxidoreductase (decarboxylating) Citrate cycle (TCA cycle) EC:1.1.1.42
fast: false
product: MODEL1310110063#
kinetic law: MODEL1310110063#
notes: GENE_ASSOCIATION: (AA081045.1) or (AI620219.1) or (219.1) or (217.1) or (224.1) or (501.1) or (223.1) or (AU149534.1) or (T83654.1) SUBSYSTEM: Unassigned EC Number: 1.1.1.42 Confidence Level: 0 AUTHORS: PMID:10521434,PMID:16489927,PMID:9866202 NOTES:
type: Reaction
modifier: MODEL1310110063#

metaM prostgd2 c
initial concentration: 1.0
initial amount: NaN
is: HMDB01403
type: Species
boundary condition: false
notes: FORMULA: C20H31O5 CHARGE: -1 INCHI: InChI=1S/C20H32O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h4,7,12-13,15-18,21-22H,2-3,5-6,8-11,14H2,1H3,(H,24,25)/p-1/b7-4-,13-12+/t15-,16+,17+,18-/m0/s1 EHMN_ABBREVIATION: C00696
has only substance units: false
is: SBO:0000247
name: prostaglandin D2(1-)
constant: false
is: CHEBI:57406

metaR DOPABMO
is: SBO:0000176
kinetic law: MODEL1310110063#
product: MODEL1310110063#
is version of: http://identifiers.org/ec-code/1.14.17.1
name: dopamine beta-monooxygenase
modifier: MODEL1310110063#
reversible: false
is described by: ECO:0000269
reactant: MODEL1310110063#
fast: false
type: Reaction
notes: GENE_ASSOCIATION: (26002.1) or (1621.1) SUBSYSTEM: Tyrosine metabolism EC Number: 1.14.17.1 Confidence Level: 4 AUTHORS: NOTES:SAB

metaR EX ctp LPAREN e RPAREN
kinetic law: MODEL1310110063#
reactant: MODEL1310110063#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of CTP(4-)
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110063#_b978fd00_9ebf_41f5_a29d_9e5d15ef0896
type: Species
boundary condition: true
name: DEGS1
is: SBO:0000252
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:8560
has only substance units: false
constant: false

metaM ksi deg9 l
name: keratan sulfate I, degradation product 9
notes: FORMULA: C188H301N13O166S10 CHARGE: -10
initial concentration: 1.0
constant: false
has only substance units: false
boundary condition: false
is: HMDB00143
is: CHEBI:12936
type: Species
initial amount: NaN
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110063#_7878777f_8fa4_437a_b64c_42223ebf00ca
constant: false
initial amount: NaN
name: GGT7
is encoded by: hsa:2686
initial concentration: NaN
is: SBO:0000252
has only substance units: false
type: Species
is: A0PJJ9
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110063#_5edcfa6e_141c_40bd_99fb_b3ca1d282796
is: B4DX62
boundary condition: true
initial amount: NaN
constant: false
name: ST3GAL3
type: Species
initial concentration: NaN
has only substance units: false
is: SBO:0000252
is encoded by: hsa:6487

metaR DAGK hs
kinetic law: MODEL1310110063#
reversible: true
is: SBO:0000176
name: Diacylglycerol phosphate kinase (homo sapiens)
modifier: MODEL1310110063#
type: Reaction
fast: false
is version of: http://identifiers.org/ec-code/2.7.1.107
reactant: MODEL1310110063#
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (9162.1) or (1607.1) or (8525.2) or (160851.1) or (1608.1) or (1607.2) or (8525.1) or (8527.1) or (1606.1) or (160851.2) or (8526.1) or (8525.3) or (1607.1) or (8527.2) or (1609.1) SUBSYSTEM: Glycerophospholipid metabolism EC Number: 2.7.1.107 Confidence Level: 4 AUTHORS: NOTES:NJ
product: MODEL1310110063#

metaR MAL Lte
reactant: MODEL1310110063#
name: Transport of L-malate
reversible: true
kinetic law: MODEL1310110063#
type: Reaction
is: SBO:0000185
is described by: ECO:0000134
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
product: MODEL1310110063#
fast: false

http://identifiers.org/biomodels.db/MODEL1310110063#_0c29ba80_92df_48c1_a64d_f91cfbe8d809
constant: false
name: SLC6A9
is encoded by: hsa:6536
has only substance units: false
is: SBO:0000252
initial concentration: NaN
is: P48067
initial amount: NaN
boundary condition: true
type: Species

metaR CSEPASEly
is described by: ECO:0000000
product: MODEL1310110063#
reversible: false
name: chondroitin sulfate E proteoglycan protease, lysosome (endosome)
notes: GENE_ASSOCIATION: SUBSYSTEM: Chondroitin sulfate degradation EC Number: Confidence Level: 1 AUTHORS: PMID:8993162 NOTES:Note that this reaction occurs in the endosome during endocytosis, but has been compartmentalized as lysosomal. NCD
reactant: MODEL1310110063#
fast: false
type: Reaction
kinetic law: MODEL1310110063#
is: SBO:0000176

metaR DOPAtu
is described by: ECO:0000269
reactant: MODEL1310110063#
name: Dopamine uniport
notes: GENE_ASSOCIATION: (6581.1) or (6582.2) or (6582.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12883891 NOTES:SAB electrogenic, Na indepdendent & rev NJ
reversible: true
fast: false
kinetic law: MODEL1310110063#
is: SBO:0000185
type: Reaction
modifier: MODEL1310110063#
product: MODEL1310110063#

http://identifiers.org/biomodels.db/MODEL1310110063#_22267539_693c_42e7_a09d_7592d9bfaeff
has only substance units: false
name: ALPP
is encoded by: hsa:250
initial concentration: NaN
constant: false
boundary condition: true
type: Species
is: SBO:0000252
initial amount: NaN
is: P05187

metaR FAOXTC122m
kinetic law: MODEL1310110063#
product: MODEL1310110063#
reactant: MODEL1310110063#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: isomerization trans(C12:2)m
type: Reaction

metaR r0424
type: Reaction
fast: false
is described by: ECO:0000000
modifier: MODEL1310110063#
is: SBO:0000176
reversible: true
product: MODEL1310110063#
is version of: http://identifiers.org/ec-code/1.17.1.4
notes: GENE_ASSOCIATION: (7498.1) SUBSYSTEM: Unassigned EC Number: 1.1.1.42 Confidence Level: 0 AUTHORS: PMID:10521434,PMID:16489927,PMID:9866202 NOTES:
kinetic law: MODEL1310110063#
name: Isocitrate:NADP+ oxidoreductase (decarboxylating) Citrate cycle (TCA cycle) EC:1.1.1.42
reactant: MODEL1310110063#

http://identifiers.org/biomodels.db/MODEL1310110063#_fe4b7b38_34b6_4ff0_8620_6da46fecaeb5
is: P28329
boundary condition: true
is encoded by: hsa:1103
type: Species
name: CHAT
is: SBO:0000252
has only substance units: false
initial amount: NaN
initial concentration: NaN
constant: false

metaM tymsf c
type: Species
initial concentration: 1.0
is: HMDB06409
notes: FORMULA: C8H11NO4S CHARGE: 0 INCHI: InChI=1/C8H11NO4S/c9-6-5-7-1-3-8(4-2-7)13-14(10,11)12/h1-4H,5-6,9H2,(H,10,11,12)
name: Tyramine O-sulfate
is: SBO:0000247
constant: false
boundary condition: false
initial amount: NaN
has only substance units: false

metaM glyc m
is: HMDB00131
name: Glycerol
initial concentration: 1.0
notes: FORMULA: C3H8O3 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00114 EHMN_ABBREVIATION: C00116
is: CHEBI:17754
is: SBO:0000247
constant: false
initial amount: NaN
has only substance units: false
type: Species
boundary condition: false
is: C00116

metaR 34DHPLACOX
fast: false
is described by: ECO:0000269
type: Reaction
is: SBO:0000176
reactant: MODEL1310110063#
modifier: MODEL1310110063#
product: MODEL1310110063#
is version of: http://identifiers.org/ec-code/1.2.1.5
reversible: false
kinetic law: MODEL1310110063#
name: 3,4-Dihydroxyphenylacetaldehyde:NAD+ oxidoreductase
notes: GENE_ASSOCIATION: (218.1) or (222.1) or (220.1) or (221.1) SUBSYSTEM: Tyrosine metabolism EC Number: 1.2.1.5 Confidence Level: 4 AUTHORS: PMID:11306106,PMID:2071588 NOTES:SAB

http://identifiers.org/biomodels.db/MODEL1310110063#_331a5e9d_3c5c_42eb_82d2_ac3e66a24c33
constant: false
is encoded by: hsa:5372
name: PMM1
boundary condition: true
has only substance units: false
type: Species
initial amount: NaN
is: SBO:0000252
initial concentration: NaN
is: A8K003

http://identifiers.org/biomodels.db/MODEL1310110063#_8cc685cb_d1f6_4415_9109_16110ecb503f
type: Species
constant: false
initial amount: NaN
is: P54868
is encoded by: hsa:3158
has only substance units: false
initial concentration: NaN
is: SBO:0000252
boundary condition: true
name: HMGCS2

metaM k c
initial concentration: 1.0
is: CHEBI:29103
type: Species
is: SBO:0000247
notes: FORMULA: K CHARGE: 1 HEPATONET_1.0_ABBREVIATION: HC00216 EHMN_ABBREVIATION: C00238
is: C00238
initial amount: NaN
is: HMDB00586
has only substance units: false
name: potassium
boundary condition: false
constant: false

metaM ctdecdcoa m
initial concentration: 1.0
boundary condition: false
notes: FORMULA: C31H46N7O17P3S CHARGE: -4
constant: false
has only substance units: false
is: HMDB00792
name: cis2trans4decadienoylcoa
is: SBO:0000247
initial amount: NaN
is: C08277
type: Species

metaR EX 5oxpro LPAREN e RPAREN
kinetic law: MODEL1310110063#
reactant: MODEL1310110063#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: Exchange of 5-oxoprolinate
type: Reaction

metaR PCRNtm
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: PMID:7654220 NOTES:NJ
reversible: false
product: MODEL1310110063#
name: transport into the mitochondria from cytosol (carnitine)
fast: false
reactant: MODEL1310110063#
is: SBO:0000185
kinetic law: MODEL1310110063#
is described by: ECO:0000000
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110063#_42423b66_a283_40d3_b213_92f4a9813b96
boundary condition: true
type: Species
name: ATP5H:ATP5L:NSF:ATP5F1:ATP5G3:ATP5I:ATP5J:ATP5J2
has part: P48201
has only substance units: false
is: SBO:0000297
constant: false
initial concentration: NaN
is encoded by: hsa:518
initial amount: NaN

metaM 1p3h5c c
initial amount: NaN
boundary condition: false
name: L-1-Pyrroline-3-hydroxy-5-carboxylate
constant: false
notes: FORMULA: C5H6NO3 CHARGE: -1 INCHI: InChI=1S/C5H7NO3/c7-3-1-4(5(8)9)6-2-3/h2-4,7H,1H2,(H,8,9)/t3-,4+/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01261 EHMN_ABBREVIATION: C04281
is: SBO:0000247
initial concentration: 1.0
has only substance units: false
is: CHEBI:6151
type: Species
is: HMDB01369

metaR SADT
kinetic law: MODEL1310110063#
is version of: http://identifiers.org/ec-code/2.7.1.25
is described by: ECO:0000269
fast: false
product: MODEL1310110063#
type: Reaction
reactant: MODEL1310110063#
modifier: MODEL1310110063#
is: SBO:0000176
name: sulfate adenylyltransferase
notes: GENE_ASSOCIATION: (9060.1) or (9061.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.7.4 Confidence Level: 4 AUTHORS: PMID:11931637,PMID:12716056 NOTES:
reversible: false

metaR RE1901R
type: Reaction
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Vitamin A metabolism EC Number: 1.2.1.36 Confidence Level: 0 AUTHORS: PMID:10559215,PMID:11007799,PMID:11279029 NOTES:
reversible: true
is: SBO:0000176
kinetic law: MODEL1310110063#
name: RE1901
product: MODEL1310110063#
reactant: MODEL1310110063#
fast: false

metaR FAOXC200180m
fast: false
name: Beta oxidation of long chain fatty acid
type: Reaction
is version of: http://identifiers.org/ec-code/1.3.8.1
modifier: MODEL1310110063#
product: MODEL1310110063#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (35.1) or (34.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.74 Confidence Level: 4 AUTHORS: NOTES:c20:0 -> c18:0 4 step FAO lumped also includes EC 1.1.1.35, 1.1.1.211, 1.3.3.6, 4.2.1.17, 4.2.1.74 NJ
kinetic law: MODEL1310110063#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.3.99.3
reactant: MODEL1310110063#
reversible: false

metaM n2m2nmasn e
is: SBO:0000247
initial amount: NaN
constant: false
notes: FORMULA: C58H96N5O40X CHARGE: 0
initial concentration: 1.0
is: C04946
boundary condition: false
has only substance units: false
name: N-Acetyl-beta-D-glucosaminyl-1,2-alpha-D-mannosyl-1,3-(N-acetyl-beta-D-glucosaminyl-1,2-alpha-D-mannosyl-1,6)-(N-acetyl-beta-D-glucosaminyl-1,4)-beta-D-mannosyl-1,4-N-acetyl-beta-D-glucosaminyl-R
type: Species

http://identifiers.org/biomodels.db/MODEL1310110063#_7977a46b_5fa1_4a59_b679_507582c54eb0
initial concentration: NaN
initial amount: NaN
type: Species
has only substance units: false
is: SBO:0000252
name: COQ6
is: Q9Y2Z9
boundary condition: true
is encoded by: hsa:51004
constant: false

metaM biocyt m
notes: FORMULA: C16H28N4O4S CHARGE: 0 INCHI: InChI=1/C16H28N4O4S/c17-10(15(22)23)5-3-4-8-18-13(21)7-2-1-6-12-14-11(9-25-12)19-16(24)20-14/h10-12,14H,1-9,17H2,(H,18,21)(H,22,23)(H2,19,20,24)/t10-,11-,12-,14-/m0/s1 EHMN_ABBREVIATION: C05552
type: Species
name: Biocytin
is: C05552
constant: false
is: http://identifiers.org/pubchem.compound/7886
is: SBO:0000247
boundary condition: false
is: HMDB03134
initial concentration: 1.0
has only substance units: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110063#_e1d0ef77_4681_41f6_beb9_b62626b2669d
name: CPT1C
constant: false
is encoded by: hsa:126129
has only substance units: false
is: SBO:0000252
initial amount: NaN
boundary condition: true
initial concentration: NaN
type: Species
is: Q8TCG5

metaM clpn hs c
boundary condition: false
type: Species
is: CHEBI:21338
constant: false
is: SBO:0000247
has only substance units: false
notes: FORMULA: CHARGE: 0
initial amount: NaN
is: HMDB02704
name: clpn_hs[c]
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110063#_92e16c3a_ba4e_4fdf_9ea8_97a8037f42d1
constant: false
is encoded by: hsa:7372
is: SBO:0000252
is: A8K5J1
initial amount: NaN
has only substance units: false
name: UMPS
boundary condition: true
initial concentration: NaN
type: Species

http://identifiers.org/biomodels.db/MODEL1310110063#_6eef5b94_26ab_4111_8ed3_47472c306118
type: Species
initial amount: NaN
initial concentration: NaN
boundary condition: true
name: SULT1A1
has only substance units: false
constant: false
is: SBO:0000252
is encoded by: hsa:6817

http://identifiers.org/biomodels.db/MODEL1310110063#_84b67654_04e6_486a_8751_3ee41c3a85fb
type: Species
has only substance units: false
constant: false
initial amount: NaN
name: GUCY1A3
is encoded by: hsa:2982
is: SBO:0000252
initial concentration: NaN
is: D6RDW3
boundary condition: true

metaM btcoa m
boundary condition: false
notes: FORMULA: C25H38N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00134 EHMN_ABBREVIATION: C00136
constant: false
initial amount: NaN
is: C00136
has only substance units: false
initial concentration: 1.0
is: CHEBI:57371
is: SBO:0000247
is: HMDB01088
name: Butanoyl-CoA
type: Species

http://identifiers.org/biomodels.db/MODEL1310110063#_14a66403_af55_4bcf_935b_2234bf583425
constant: false
is: Q6FGA0
initial concentration: NaN
type: Species
boundary condition: true
has only substance units: false
is encoded by: hsa:9167
name: COX7A2L
is: SBO:0000252
initial amount: NaN

metaR PROSTGF2t
reversible: true
is described by: ECO:0000269
is: SBO:0000185
kinetic law: MODEL1310110063#
notes: GENE_ASSOCIATION: (6582.2) or (6582.1) or (6580.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12827517,PMID:12883891,PMID:9187257 NOTES:electrogenic, Na indepdendent & rev NJ
type: Reaction
name: prostaglandin uniport
product: MODEL1310110063#
fast: false
modifier: MODEL1310110063#
reactant: MODEL1310110063#

metaM 2maacoa m
is: SBO:0000247
notes: FORMULA: C26H38N7O18P3S CHARGE: -4 INCHI: InChI=1S/C26H42N7O18P3S/c1-13(14(2)34)25(39)55-8-7-28-16(35)5-6-29-23(38)20(37)26(3,4)10-48-54(45,46)51-53(43,44)47-9-15-19(50-52(40,41)42)18(36)24(49-15)33-12-32-17-21(27)30-11-31-22(17)33/h11-13,15,18-20,24,36-37H,5-10H2,1-4H3,(H,28,35)(H,29,38)(H,43,44)(H,45,46)(H2,27,30,31)(H2,40,41,42)/p-4/t13?,15-,18-,19-,20+,24-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01101 EHMN_ABBREVIATION: C03344
is: HMDB01157
initial amount: NaN
type: Species
initial concentration: 1.0
has only substance units: false
constant: false
is: CHEBI:57335
name: 2-methylacetoacetyl-CoA(4-)
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110063#_175da4d8_6223_41a4_865f_bf0d27096b58
is: SBO:0000252
constant: false
type: Species
name: PIGX
is encoded by: hsa:54965
initial amount: NaN
is: Q8TBF5
boundary condition: true
initial concentration: NaN
has only substance units: false

metaM sbcoa x
type: Species
is: http://identifiers.org/pubchem.compound/16019966
boundary condition: false
notes: FORMULA: C29H43N7O19P3S CHARGE: -5
initial concentration: 1.0
has only substance units: false
is: SBO:0000247
constant: false
name: suberylcoa
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110063#_228fd520_9fa8_4def_aa1f_8a0104b83df7
is: SBO:0000252
initial amount: NaN
boundary condition: true
name: INPP5J
is encoded by: hsa:27124
initial concentration: NaN
constant: false
type: Species
has only substance units: false

metaR RE3326M
is: SBO:0000176
notes: GENE_ASSOCIATION: (594.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:2699399,PMID:9665099 NOTES:
reactant: MODEL1310110063#
fast: false
modifier: MODEL1310110063#
name: RE3326
reversible: true
product: MODEL1310110063#
kinetic law: MODEL1310110063#
is version of: http://identifiers.org/ec-code/1.2.4.4
type: Reaction
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110063#_8ff0e843_6b5d_4d96_841a_de9f1ac708a2
is encoded by: hsa:7084
is: O00142
initial amount: NaN
name: TK2
initial concentration: NaN
constant: false
type: Species
has only substance units: false
is: SBO:0000252
boundary condition: true

metaM 2mop m
initial concentration: 1.0
type: Species
is: SBO:0000247
notes: FORMULA: C4H5O3 CHARGE: -1 INCHI: InChI=1S/C4H6O3/c1-3(2-5)4(6)7/h2-3H,1H3,(H,6,7)/p-1 HEPATONET_1.0_ABBREVIATION: HC00296 EHMN_ABBREVIATION: C00349
is: CHEBI:57700
is: HMDB01172
name: 2-methyl-3-oxopropanoate
constant: false
has only substance units: false
boundary condition: false
initial amount: NaN

metaR SAMHISTA
kinetic law: MODEL1310110063#
reversible: false
reactant: MODEL1310110063#
product: MODEL1310110063#
type: Reaction
name: S-Adenosyl-L-methionine:histamine N-tele-methyltransferase
is version of: http://identifiers.org/ec-code/2.1.1.8
modifier: MODEL1310110063#
is: SBO:0000176
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (3176.1) SUBSYSTEM: Histidine metabolism EC Number: 2.1.1.8 Confidence Level: 4 AUTHORS: PMID:7943261 NOTES:SAB R02155
fast: false

metaM gly x
is: HMDB00123
notes: FORMULA: C2H5NO2 CHARGE: 0 INCHI: InChI=1S/C2H5NO2/c3-1-2(4)5/h1,3H2,(H,4,5) HEPATONET_1.0_ABBREVIATION: HC00045 EHMN_ABBREVIATION: C00037
is: CHEBI:15428
constant: false
boundary condition: false
initial amount: NaN
type: Species
has only substance units: false
name: glycine
is: SBO:0000247
initial concentration: 1.0

metaR r1384
product: MODEL1310110063#
notes: GENE_ASSOCIATION: SUBSYSTEM: Nucleotide interconversion EC Number: 3.5.4.15 Confidence Level: 0 AUTHORS: PMID:10348987,PMID:14725335 NOTES:
name: Guanosine aminohydrolase EC:3.5.4.15
reactant: MODEL1310110063#
kinetic law: MODEL1310110063#
is described by: ECO:0000000
reversible: true
is: SBO:0000176
fast: false
type: Reaction

MODEL1310110063#
species: metaM m3mpdol U c
species: metaM 6pgl r
stoichiometry: 0.545544
stoichiometry: 0.392525
species: metaM akg c
species: metaM udp n
species: metaM sgalside hs c
species: metaM mlthf m
species: metaM mlthf c
species: metaM 4abutn m
species: metaM 4abutn c
species: metaM nm2masn g
species: metaM 3mlda e
species: metaM thexddcoa m
species: metaM acetone e
species: metaM retn r
species: metaM ksii core4 g
species: metaM retfa e
species: metaM phe L e
species: metaM ahcys m
species: metaM cit m
species: metaM drib c
species: metaM clpnd e
species: metaM hpdca e
species: metaM hdca e
species: metaM 2decdicoa x
species: metaM HC00900 m
species: metaM Rtotal3coa c
species: metaM lnlncacoa c
species: metaM pail3p hs n
species: metaM ump e
species: metaM 3aib D m
stoichiometry: 7.92
species: metaM chsterol c
species: metaM bildglcur r
species: metaM L2aadp m
species: metaM gal e
stoichiometry: 0.154463
species: metaM ddcacoa x
species: metaM dsmsterol r
species: metaM decdicrn e
species: metaM 3hexdtetcoa m
species: metaM hmgcoa x
species: metaM tettet6coa x
species: metaM fuc L c
species: metaM leuktrA4 c
species: metaM crvnc c
species: metaM HC02121 c
species: metaM mma c
species: metaM lneldc e
species: metaM tetdece1crn e
species: metaM retn c
species: metaM ksii core2 pre2 g
species: metaM tethex3coa c
species: metaM gthox m
species: metaM gthox c
species: metaM nicrns c
species: metaM s2l2fn2m2masn e
name: PIK3CD:PIK3R1
species: metaM 2octdectecoa m
species: metaM stcoa m
species: metaM leugly e
species: metaM lnlc e
species: metaM ksi pre1 g
species: metaM pap g
species: metaM dcsptn1coa m
species: metaM dcsptn1coa c
species: metaM thyox L e
species: metaM 4izp c
species: metaM dgtp n
species: metaM leuleu e
species: metaM ksi deg21 l
species: metaM accoa c
species: metaM em2emgacpail hs r
species: metaM nad c
species: metaM thcholstoic c
species: metaM CE2424 m
species: metaM lald D c
species: metaM leu L e
species: metaM 3deccrn e

metaR r1677
name: Y+LAT2 Utilized transport
kinetic law: MODEL1310110063#
product: MODEL1310110063#
modifier: MODEL1310110063#
fast: false
is: SBO:0000185
reversible: false
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
type: Reaction
reactant: MODEL1310110063#
is described by: ECO:0000000

metaM biocyt n
initial amount: NaN
name: Biocytin
has only substance units: false
type: Species
is: C05552
is: HMDB03134
notes: FORMULA: C16H28N4O4S CHARGE: 0 INCHI: InChI=1/C16H28N4O4S/c17-10(15(22)23)5-3-4-8-18-13(21)7-2-1-6-12-14-11(9-25-12)19-16(24)20-14/h10-12,14H,1-9,17H2,(H,18,21)(H,22,23)(H2,19,20,24)/t10-,11-,12-,14-/m0/s1 EHMN_ABBREVIATION: C05552
constant: false
boundary condition: false
is: http://identifiers.org/pubchem.compound/7886
initial concentration: 1.0
is: SBO:0000247

metaM xol7aone m
notes: FORMULA: C27H44O2 CHARGE: 0 INCHI: InChI=1S/C27H44O2/c1-17(2)7-6-8-18(3)21-9-10-22-25-23(12-14-27(21,22)5)26(4)13-11-20(28)15-19(26)16-24(25)29/h15,17-18,21-25,29H,6-14,16H2,1-5H3/t18-,21-,22+,23+,24-,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01464 EHMN_ABBREVIATION: C05455
is: CHEBI:17899
name: 7alpha-hydroxycholest-4-en-3-one
is: SBO:0000247
type: Species
boundary condition: false
initial concentration: 1.0
constant: false
has only substance units: false
initial amount: NaN
is: HMDB01993

http://identifiers.org/biomodels.db/MODEL1310110063#_cb355e71_cdd8_4157_a501_b36f602d6d0e
type: Species
has only substance units: false
is: P49247
boundary condition: true
constant: false
is encoded by: hsa:22934
initial amount: NaN
name: RPIA
is: SBO:0000252
initial concentration: NaN

metaR RAtn3
name: 13-cis-retinoic acid transport, nuclear
fast: false
product: MODEL1310110063#
is described by: ECO:0000000
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: PMID:1503811 NOTES:IT
type: Reaction
kinetic law: MODEL1310110063#
reversible: true
reactant: MODEL1310110063#

metaM 5htrp c
type: Species
has only substance units: false
constant: false
name: 5-hydroxy-L-tryptophan
is: SBO:0000247
is: CHEBI:17780
initial amount: NaN
initial concentration: 1.0
is: HMDB00472
notes: FORMULA: C11H12N2O3 CHARGE: 0 INCHI: InChI=1S/C11H12N2O3/c12-9(11(15)16)3-6-5-13-10-2-1-7(14)4-8(6)10/h1-2,4-5,9,13-14H,3,12H2,(H,15,16)/t9-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00472 EHMN_ABBREVIATION: C00643
boundary condition: false

metaR r0575
is: SBO:0000176
fast: false
type: Reaction
reactant: MODEL1310110063#
is version of: http://identifiers.org/ec-code/2.7.1.48
reversible: true
product: MODEL1310110063#
kinetic law: MODEL1310110063#
notes: GENE_ASSOCIATION: (AA021081.1) or (AI440329.1) or (R06874.1) or (83549.1) or (7371.1) or (54963.1) SUBSYSTEM: Cholesterol metabolism EC Number: 2.5.1.21 Confidence Level: 0 AUTHORS: PMID:10449533,PMID:1527001,PMID:7864626,PMID:8509416 NOTES:
name: Presqualene diphosphate:farnesyl-diphosphate farnesyltransferase Biosynthesis of steroids EC:2.5.1.21
modifier: MODEL1310110063#
is described by: ECO:0000000

metaR RE0935E
modifier: MODEL1310110063#
is version of: http://identifiers.org/ec-code/3.2.1.17
reversible: true
is: SBO:0000176
product: MODEL1310110063#
kinetic law: MODEL1310110063#
is described by: ECO:0000000
name: RE0935
type: Reaction
reactant: MODEL1310110063#
is version of: http://identifiers.org/ec-code/3.2.1.1
notes: GENE_ASSOCIATION: (276.1) or (277.1) or (278.1) or (279.1) or (276.1) or (277.1) or (278.1) or (279.1) or (280.1) or (84569.1) SUBSYSTEM: Starch and sucrose metabolism EC Number: 3.2.1.1 Confidence Level: 0 AUTHORS: PMID:385176,PMID:8528071,PMID:890964 NOTES:
fast: false

http://identifiers.org/biomodels.db/MODEL1310110063#_31630b0e_b6c7_46ff_8ca9_38f7bd639297
type: Species
initial concentration: NaN
constant: false
initial amount: NaN
is: SBO:0000252
name: HAS1
is encoded by: hsa:3036
boundary condition: true
has only substance units: false
is: Q8IYH3

metaM cspg b e
is: HMDB00300
initial amount: NaN
constant: false
has only substance units: false
is: CHEBI:17568
type: Species
is: SBO:0000247
boundary condition: false
name: chondroitin sulfate B / dermatan sulfate (IdoA2S-GalNAc4S) proteoglycan
initial concentration: 1.0
notes: FORMULA: C45H65N2O48S4X CHARGE: -6
is: C00106

metaM m3gacpail hs r
type: Species
constant: false
initial amount: NaN
notes: FORMULA: C49H88NO29PFULLRCO2FULLR2CO2 CHARGE: 0
name: trimannosyl-glucosaminyl-acylphosphatidylinositol (H4)
is: CHEBI:16240
has only substance units: false
is: HMDB03125
boundary condition: false
is: SBO:0000247
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110063#_7ba1b3c2_02fd_4183_b58d_37bac881cff0
type: Species
initial concentration: NaN
is: Q96FL9
is encoded by: hsa:79623
constant: false
has only substance units: false
name: GALNT14
boundary condition: true
initial amount: NaN
is: SBO:0000252

metaR G6Pter
notes: GENE_ASSOCIATION: (2542.1) SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 4 AUTHORS: PMID:11032333,PMID:11140953,PMID:11879177,PMID:9428641 NOTES:NCD
reversible: true
name: glucose 6-phosphate endoplasmic reticular transport via diffusion
fast: false
modifier: MODEL1310110063#
is: SBO:0000185
is described by: ECO:0000269
kinetic law: MODEL1310110063#
type: Reaction
reactant: MODEL1310110063#
product: MODEL1310110063#

metaR LTC4CP
reversible: true
type: Reaction
kinetic law: MODEL1310110063#
notes: GENE_ASSOCIATION: SUBSYSTEM: Eicosanoid metabolism EC Number: 2.3.2.2 Confidence Level: 2 AUTHORS: PMID:12729612 NOTES:Converts leukotriene C4 (LTC4) to leukotriene F4 (LTF4). NJ
is described by: ECO:0000000
name: Leukotriene C4 carboxypeptidase
fast: false
reactant: MODEL1310110063#
product: MODEL1310110063#
is: SBO:0000176

metaR C101CPT1
kinetic law: MODEL1310110063#
product: MODEL1310110063#
reactant: MODEL1310110063#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: production of decenoylcarnitine
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110063#_1af55f42_5888_4ef7_b782_cfa07ed933ef
initial concentration: NaN
has only substance units: false
name: PHYH
constant: false
initial amount: NaN
is: O14832
type: Species
boundary condition: true
is: SBO:0000252
is encoded by: hsa:5264

metaM crvnc c
is: SBO:0000247
initial concentration: 1.0
type: Species
initial amount: NaN
boundary condition: false
is: CHEBI:36005
constant: false
notes: FORMULA: C22H31O2 CHARGE: -1
is: HMDB02183
name: cervonic acid, C22:6 n-3
has only substance units: false

metaM glc D e
notes: FORMULA: C6H12O6 CHARGE: 0 INCHI: InChI=1S/C6H12O6/c7-1-2-3(8)4(9)5(10)6(11)12-2/h2-11H,1H2/t2-,3-,4+,5-,6?/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00040
has only substance units: false
type: Species
name: D-glucose
is: SBO:0000247
is: CHEBI:4167
boundary condition: false
initial amount: NaN
is: HMDB00122
constant: false
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110063#_43dde7c0_a236_437b_a050_a52a7a031266
constant: false
has part: P05166
name: PCCA:PCCB
initial concentration: NaN
is: SBO:0000297
has only substance units: false
type: Species
is encoded by: hsa:5096
initial amount: NaN
has part: C9JPQ8
boundary condition: true
is encoded by: hsa:5095

metaR EX ksi deg1 LPAREN e RPAREN
kinetic law: MODEL1310110063#
reactant: MODEL1310110063#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: keratan sulfate I, degradation product 1 exchange
type: Reaction

metaR LPASE
reactant: MODEL1310110063#
is described by: ECO:0000000
product: MODEL1310110063#
fast: false
reversible: false
name: lysophospholipase
is version of: http://identifiers.org/ec-code/3.1.1.5
notes: GENE_ASSOCIATION: (5321.1) or (1178.1) or (29124.1) SUBSYSTEM: Glycerophospholipid metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:9430701 NOTES:phosphatidyl choline degradation NJ
modifier: MODEL1310110063#
is: SBO:0000176
type: Reaction
kinetic law: MODEL1310110063#

metaR EX ac LPAREN e RPAREN
kinetic law: MODEL1310110063#
reactant: MODEL1310110063#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Acetate exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110063#_999f4fd1_ce11_4e70_ada1_dd87e052576f
initial amount: NaN
is encoded by: hsa:3284
constant: false
type: Species
name: HSD3B2
has only substance units: false
is: SBO:0000252
initial concentration: NaN
is: P26439
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110063#_7c0cca52_f199_479d_a1b6_2c1e03b3584b
has only substance units: false
type: Species
name: _22305_1_c
constant: false
initial amount: NaN
initial concentration: NaN
boundary condition: true
is encoded by: hsa:22305
is: SBO:0000252

metaM met L c
is: CHEBI:16643
type: Species
is: SBO:0000247
notes: FORMULA: C5H11NO2S CHARGE: 0 INCHI: InChI=1S/C5H11NO2S/c1-9-3-2-4(6)5(7)8/h4H,2-3,6H2,1H3,(H,7,8)/t4-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00075
constant: false
boundary condition: false
initial concentration: 1.0
name: L-methionine
has only substance units: false
is: HMDB00696
initial amount: NaN

metaM chol n
initial amount: NaN
is: HMDB00097
name: choline
is: SBO:0000247
is: CHEBI:15354
type: Species
constant: false
boundary condition: false
initial concentration: 1.0
has only substance units: false
notes: FORMULA: C5H14NO CHARGE: 1 INCHI: InChI=1S/C5H14NO/c1-6(2,3)4-5-7/h7H,4-5H2,1-3H3/q+1 HEPATONET_1.0_ABBREVIATION: HC00112 EHMN_ABBREVIATION: C00114

metaR 3SALAASPm
is described by: ECO:0000304
is: SBO:0000185
reversible: true
fast: false
name: cysteinesulfinate-aspartate mitochondrial shuttle
type: Reaction
product: MODEL1310110063#
modifier: MODEL1310110063#
kinetic law: MODEL1310110063#
notes: GENE_ASSOCIATION: (10165.1) or (8604.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: PMID:14598172 NOTES:PMID:486467 MM
reactant: MODEL1310110063#

metaR EX tetpent6 LPAREN e RPAREN
kinetic law: MODEL1310110063#
reactant: MODEL1310110063#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: tetracosapentaenoic acid, n-6 exchange
type: Reaction

metaR HEXCt
fast: false
kinetic law: MODEL1310110063#
reversible: true
reactant: MODEL1310110063#
name: fatty acid transport via diffusion
is described by: ECO:0000000
product: MODEL1310110063#
type: Reaction
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11788354,PMID:12864740 NOTES:NJ

http://identifiers.org/biomodels.db/MODEL1310110063#_ec903f82_165d_4c94_a667_8a35766ac846
constant: false
has only substance units: false
initial amount: NaN
is: Q04828
initial concentration: NaN
is encoded by: hsa:1645
boundary condition: true
is: SBO:0000252
type: Species
name: AKR1C1

metaM Rtotalcoa c
is: CHEBI:16189
type: Species
notes: FORMULA: CO2FULLRC21H31N7O15P3S CHARGE: -4
is: HMDB01448
is: SBO:0000247
constant: false
boundary condition: false
has only substance units: false
initial concentration: 1.0
initial amount: NaN
name: R total Coenzyme A

http://identifiers.org/biomodels.db/MODEL1310110063#_570dee78_4485_4d37_8aeb_1b2793932478
initial concentration: NaN
is encoded by: hsa:5244
constant: false
initial amount: NaN
type: Species
boundary condition: true
name: ABCB4
is: SBO:0000252
has only substance units: false

metaR GLCNACASE2ly
kinetic law: MODEL1310110063#
is version of: http://identifiers.org/ec-code/3.2.1.50
reactant: MODEL1310110063#
fast: false
product: MODEL1310110063#
type: Reaction
name: alpha-N-acetylglucosaminidase, lysosomal
reversible: false
modifier: MODEL1310110063#
notes: GENE_ASSOCIATION: (4669.1) SUBSYSTEM: Heparan sulfate degradation EC Number: 3.2.1.50 Confidence Level: 4 AUTHORS: PMID:1783617,PMID:8776591,PMID:8993162 NOTES:NCD
is: SBO:0000176
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110063#_154109f2_d453_4142_8f7a_cf754fa308aa
is: P03915
initial concentration: NaN
is: SBO:0000252
name: ND5
type: Species
constant: false
has only substance units: false
initial amount: NaN
boundary condition: true
is encoded by: hsa:4540

http://identifiers.org/biomodels.db/MODEL1310110063#_e4a73919_33e3_49f4_8d87_154fdc7f5447
initial concentration: NaN
boundary condition: true
name: PPCDC
is: Q96CD2
is: SBO:0000252
initial amount: NaN
has only substance units: false
is encoded by: hsa:60490
constant: false
type: Species

metaM 3ivcoa m
is: C05998
initial amount: NaN
has only substance units: false
initial concentration: 1.0
type: Species
is: SBO:0000247
boundary condition: false
is: HMDB06870
name: 3-hydroxyisovalerylcoa
notes: FORMULA: C26H40N7O18P3S CHARGE: -4
constant: false
is: http://identifiers.org/pubchem.compound/11966188

http://identifiers.org/biomodels.db/MODEL1310110063#_b1be6d19_9104_4378_8adc_550256844000
constant: false
is encoded by: hsa:3038
is: Q96RV2
initial amount: NaN
name: HAS3
initial concentration: NaN
type: Species
has only substance units: false
is: SBO:0000252
boundary condition: true

metaM chol m
is: CHEBI:15354
initial amount: NaN
is: HMDB00097
is: SBO:0000247
name: choline
has only substance units: false
type: Species
constant: false
boundary condition: false
initial concentration: 1.0
notes: FORMULA: C5H14NO CHARGE: 1 INCHI: InChI=1S/C5H14NO/c1-6(2,3)4-5-7/h7H,4-5H2,1-3H3/q+1 HEPATONET_1.0_ABBREVIATION: HC00112 EHMN_ABBREVIATION: C00114

http://identifiers.org/biomodels.db/MODEL1310110063#_0bb505aa_c7fb_475f_94ab_57b84d1efb9e
type: Species
is encoded by: hsa:130367
name: SGPP2
constant: false
has only substance units: false
is: SBO:0000252
is: Q8IWX5
boundary condition: true
initial concentration: NaN
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110063#_bb0b314e_6029_4d0d_beb7_f5aa3ea3eb05
is encoded by: hsa:NM 013421
initial concentration: NaN
name: _NM_013421_1_m
type: Species
is: SBO:0000252
constant: false
initial amount: NaN
has only substance units: false
boundary condition: true

metaR TDCHOLAtx
type: Reaction
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: NOTES:unknown mechanism, however bile acids need to be secreted out of the cell NJ
is described by: ECO:0000000
name: bile acid intracellular transport
is: SBO:0000185
product: MODEL1310110063#
reactant: MODEL1310110063#
kinetic law: MODEL1310110063#
fast: false

metaR EX gmp LPAREN e RPAREN
kinetic law: MODEL1310110063#
reactant: MODEL1310110063#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: GMP exchange
type: Reaction

metaM 3sala m
initial concentration: 1.0
has only substance units: false
type: Species
is: C00606
is: CHEBI:61085
name: 3-sulfino-L-alanine (1-)
is: SBO:0000247
notes: FORMULA: C3H5NO4S CHARGE: -2 INCHI: InChI=1S/C3H7NO4S/c4-2(3(5)6)1-9(7)8/h2H,1,4H2,(H,5,6)(H,7,8)/p-1/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00451 EHMN_ABBREVIATION: C00606
initial amount: NaN
constant: false
boundary condition: false

metaM crvnc e
name: cervonic acid, C22:6 n-3
has only substance units: false
type: Species
is: CHEBI:36005
initial amount: NaN
is: SBO:0000247
constant: false
is: HMDB02183
notes: FORMULA: C22H31O2 CHARGE: -1
initial concentration: 1.0
boundary condition: false

metaM glc D c
name: D-glucose
notes: FORMULA: C6H12O6 CHARGE: 0 INCHI: InChI=1S/C6H12O6/c7-1-2-3(8)4(9)5(10)6(11)12-2/h2-11H,1H2/t2-,3-,4+,5-,6?/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00040
boundary condition: false
is: SBO:0000247
type: Species
initial concentration: 1.0
is: CHEBI:4167
initial amount: NaN
is: HMDB00122
constant: false
has only substance units: false

metaR r1381
name: 5alpha-Cholest-7-en-3beta-ol delta7-delta8-isomerase Biosynthesis of steroids EC:5.3.3.5
product: MODEL1310110063#
is described by: ECO:0000000
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Cholesterol metabolism EC Number: 5.3.3.5 Confidence Level: 0 AUTHORS: PMID:12133002,PMID:4475632,PMID:5810070 NOTES:
type: Reaction
reversible: true
fast: false
kinetic law: MODEL1310110063#
reactant: MODEL1310110063#

http://identifiers.org/biomodels.db/MODEL1310110063#_9dc8acb0_431b_4225_960b_a23396a1357a
is encoded by: hsa:55907
has only substance units: false
is: Q8NFW8
initial concentration: NaN
is: SBO:0000252
type: Species
name: CMAS
initial amount: NaN
boundary condition: true
constant: false

http://identifiers.org/biomodels.db/MODEL1310110063#_db576dbb_b967_4a18_852c_5bac3d540c0c
type: Species
constant: false
is: SBO:0000252
boundary condition: true
initial concentration: NaN
initial amount: NaN
name: SMPD3
is: Q9NY59
is encoded by: hsa:55512
has only substance units: false

metaM xoltriol c
type: Species
name: 5beta-cholestane-3alpha,7alpha,12alpha-triol
boundary condition: false
initial amount: NaN
constant: false
notes: FORMULA: C27H48O3 CHARGE: 0 INCHI: InChI=1S/C27H48O3/c1-16(2)7-6-8-17(3)20-9-10-21-25-22(15-24(30)27(20,21)5)26(4)12-11-19(28)13-18(26)14-23(25)29/h16-25,28-30H,6-15H2,1-5H3/t17-,18+,19-,20-,21+,22+,23-,24+,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01463 EHMN_ABBREVIATION: C05454
is: CHEBI:16496
initial concentration: 1.0
is: SBO:0000247
has only substance units: false
is: HMDB01457

metaM hs deg23 l
name: GlcNAc(3S)-alpha-1,4-GlcA-beta-1,3-Gal-beta-1,3-Gal-beta-1,4-Xylose
constant: false
has only substance units: false
boundary condition: false
initial amount: NaN
is: HMDB02704
notes: FORMULA: C31H49NO29S CHARGE: -2
is: SBO:0000247
type: Species
is: CHEBI:21338
initial concentration: 1.0

metaR r0578
fast: false
is described by: ECO:0000000
is: SBO:0000176
reversible: true
is version of: http://identifiers.org/ec-code/4.1.2.27
type: Reaction
kinetic law: MODEL1310110063#
modifier: MODEL1310110063#
name: ATP:pantothenate 4-phosphotransferase Pantothenate and CoA biosynthesis EC:2.7.1.33
notes: GENE_ASSOCIATION: (8879.1) SUBSYSTEM: CoA synthesis EC Number: 2.7.1.33 Confidence Level: 0 AUTHORS: PMID:13163064,PMID:15105273,PMID:15659606 NOTES:
reactant: MODEL1310110063#
product: MODEL1310110063#

http://identifiers.org/biomodels.db/MODEL1310110063#_361768be_ee2e_443a_8733_94df639b4891
name: NDUFB6
is: Q5VYT2
boundary condition: true
is: SBO:0000252
constant: false
initial concentration: NaN
is encoded by: hsa:4712
has only substance units: false
initial amount: NaN
type: Species

metaR P5CRm
reactant: MODEL1310110063#
modifier: MODEL1310110063#
fast: false
name: pyrroline-5-carboxylate reductase (m)
type: Reaction
kinetic law: MODEL1310110063#
product: MODEL1310110063#
is: SBO:0000176
is described by: ECO:0000304
reversible: false
notes: GENE_ASSOCIATION: (5831.1) or (5831.2) SUBSYSTEM: Arginine and Proline Metabolism EC Number: 1.5.1.2 Confidence Level: 2 AUTHORS: NOTES:
is version of: http://identifiers.org/ec-code/1.5.1.2

metaM mhista c
is: CHEBI:58600
name: N(tele)-methylhistaminium
has only substance units: false
initial concentration: 1.0
notes: FORMULA: C6H12N3 CHARGE: 1 INCHI: InChI=1S/C6H11N3/c1-9-4-6(2-3-7)8-5-9/h4-5H,2-3,7H2,1H3/p+1 EHMN_ABBREVIATION: C05127
constant: false
is: HMDB00898
initial amount: NaN
boundary condition: false
type: Species
is: SBO:0000247

metaM decdp c
type: Species
initial amount: NaN
constant: false
boundary condition: false
has only substance units: false
is: SBO:0000247
name: all trans Decaprenyl diphosphate
is: HMDB06288
initial concentration: 1.0
notes: FORMULA: C50H81O7P2 CHARGE: -3 INCHI: InChI=1/C50H90O7P2/c1-41(2)21-31-53-58(51,54-32-22-42(3)4)57-59(52,35-25-45(9)10,36-26-46(11)12,37-27-47(13)14,38-28-48(15)16,39-29-49(17)18,40-30-50(19)20,55-33-23-43(5)6)56-34-24-44(7)8/h21-30H,31-40H2,1-20H3

metaM met L e
type: Species
boundary condition: false
has only substance units: false
is: HMDB00696
initial amount: NaN
is: CHEBI:16643
name: L-methionine
is: SBO:0000247
initial concentration: 1.0
constant: false
notes: FORMULA: C5H11NO2S CHARGE: 0 INCHI: InChI=1S/C5H11NO2S/c1-9-3-2-4(6)5(7)8/h4H,2-3,6H2,1H3,(H,7,8)/t4-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00075

metaM dttp n
initial concentration: 1.0
initial amount: NaN
type: Species
boundary condition: false
notes: FORMULA: C10H13N2O14P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00368 EHMN_ABBREVIATION: C00459
has only substance units: false
is: CHEBI:37568
is: C00459
name: dTTP
is: HMDB01342
constant: false
is: SBO:0000247

metaR APOCF
name: Apocarboxylase formation
notes: GENE_ASSOCIATION: SUBSYSTEM: Biotin metabolism EC Number: Confidence Level: 2 AUTHORS: PMID:10191093 NOTES:IT faked reaction to balance reaction in human biotin metabolism
fast: false
is: SBO:0000176
product: MODEL1310110063#
reversible: false
is described by: ECO:0000000
kinetic law: MODEL1310110063#
reactant: MODEL1310110063#
type: Reaction

metaR 3MOPt2im
fast: false
is: SBO:0000185
reversible: false
type: Reaction
kinetic law: MODEL1310110063#
product: MODEL1310110063#
reactant: MODEL1310110063#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:8428987 NOTES:MM
is described by: ECO:0000000
name: 3-Methyl-2-oxopentanoate mitochondrial transport via proton symport

http://identifiers.org/biomodels.db/MODEL1310110063#_d55d7a5a_3dcb_43a3_9567_d707db0092fc
initial concentration: NaN
boundary condition: true
is: SBO:0000252
has only substance units: false
is encoded by: hsa:8898
type: Species
constant: false
is: A6NN98
initial amount: NaN
name: MTMR2

metaR r1380
type: Reaction
reversible: true
product: MODEL1310110063#
fast: false
kinetic law: MODEL1310110063#
notes: GENE_ASSOCIATION: SUBSYSTEM: Cholesterol metabolism EC Number: 1.3.1.72 Confidence Level: 0 AUTHORS: PMID:12162789,PMID:9291139,PMID:9638657 NOTES:
reactant: MODEL1310110063#
name: delta24-sterol reductase Biosynthesis of steroids EC:1.3.1.72
is described by: ECO:0000000
is: SBO:0000176

metaR EX leu L LPAREN e RPAREN
kinetic law: MODEL1310110063#
reactant: MODEL1310110063#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: L-Leucine exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110063#_cf82b3eb_80cd_4a72_92f3_68fb607a538a
type: Species
has only substance units: false
initial amount: NaN
initial concentration: NaN
is: P36957
name: DLST
is: SBO:0000252
is encoded by: hsa:1743
constant: false
boundary condition: true

metaR r0579
reactant: MODEL1310110063#
product: MODEL1310110063#
notes: GENE_ASSOCIATION: (84890.1) or (AV713053.1) SUBSYSTEM: CoA synthesis EC Number: 2.7.1.33 Confidence Level: 0 AUTHORS: PMID:13163064,PMID:15105273,PMID:15659606 NOTES:
fast: false
modifier: MODEL1310110063#
is version of: http://identifiers.org/ec-code/1.13.11.19
kinetic law: MODEL1310110063#
is described by: ECO:0000000
is: SBO:0000176
reversible: true
name: ATP:pantothenate 4-phosphotransferase Pantothenate and CoA biosynthesis EC:2.7.1.33
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110063#_9b1b2999_7ce1_44fb_a9d9_21fcb671f037
is: B3KTQ4
name: B3GALNT1
boundary condition: true
initial concentration: NaN
type: Species
constant: false
is: SBO:0000252
is encoded by: hsa:8706
has only substance units: false
initial amount: NaN

metaM glutcoa c
initial amount: NaN
has only substance units: false
type: Species
name: glutaryl-CoA(5-)
is: HMDB01339
notes: FORMULA: C26H37N7O19P3S CHARGE: -5 INCHI: InChI=1S/C26H42N7O19P3S/c1-26(2,21(39)24(40)29-7-6-15(34)28-8-9-56-17(37)5-3-4-16(35)36)11-49-55(46,47)52-54(44,45)48-10-14-20(51-53(41,42)43)19(38)25(50-14)33-13-32-18-22(27)30-12-31-23(18)33/h12-14,19-21,25,38-39H,3-11H2,1-2H3,(H,28,34)(H,29,40)(H,35,36)(H,44,45)(H,46,47)(H2,27,30,31)(H2,41,42,43)/p-5/t14-,19-,20-,21+,25-/m1/s1
boundary condition: false
initial concentration: 1.0
constant: false
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110063#_8c9dd23d_aee7_4fbe_bc6a_7534bdf35070
type: Species
has only substance units: false
is: Q8NFW8
name: CMAS
boundary condition: true
is: SBO:0000252
initial amount: NaN
constant: false
initial concentration: NaN
is encoded by: hsa:55907

http://identifiers.org/biomodels.db/MODEL1310110063#_d3f2bd84_536d_4f69_9150_d14164a4d6c7
initial amount: NaN
has only substance units: false
is encoded by: hsa:26289
type: Species
constant: false
is: SBO:0000252
boundary condition: true
is: Q9Y6K8
name: AK5
initial concentration: NaN

metaR r1673
is described by: ECO:0000000
kinetic law: MODEL1310110063#
fast: false
name: Y+LAT2 Utilized transport
product: MODEL1310110063#
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
modifier: MODEL1310110063#
is: SBO:0000185
reversible: false
type: Reaction
reactant: MODEL1310110063#

metaM ahdt e
notes: FORMULA: C9H12N5O13P3 CHARGE: -4 INCHI: InChI=1S/C9H16N5O13P3/c10-9-13-7-5(8(17)14-9)12-3(1-11-7)6(16)4(15)2-25-29(21,22)27-30(23,24)26-28(18,19)20/h4,6,15-16H,1-2H2,(H,21,22)(H,23,24)(H2,18,19,20)(H4,10,11,13,14,17)/p-4/t4-,6+/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01367 EHMN_ABBREVIATION: C04895
is: SBO:0000247
is: HMDB00980
has only substance units: false
name: 7,8-dihydroneopterin 3'-triphosphate(4-)
boundary condition: false
type: Species
constant: false
initial amount: NaN
is: CHEBI:58462
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110063#_16031901_4316_4386_892c_b34f01e7f44f
is: SBO:0000252
initial amount: NaN
boundary condition: true
type: Species
is: C9JC79
has only substance units: false
name: SCP2
constant: false
is encoded by: hsa:6342
initial concentration: NaN

metaM glyc c
has only substance units: false
is: CHEBI:17754
constant: false
type: Species
initial concentration: 1.0
boundary condition: false
initial amount: NaN
is: SBO:0000247
is: HMDB00131
name: Glycerol
is: C00116
notes: FORMULA: C3H8O3 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00114 EHMN_ABBREVIATION: C00116

metaR AHEXASE2ly
type: Reaction
name: beta-N-acetylhexosaminidase, lysosomal
reversible: false
modifier: MODEL1310110063#
notes: GENE_ASSOCIATION: (3074.1) or (3073.1) or (3073.1 and 3074.1) SUBSYSTEM: N-glycan degradation EC Number: 3.2.1.52 Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12706724 NOTES:NCD
is version of: http://identifiers.org/ec-code/3.2.1.52
fast: false
is: SBO:0000176
kinetic law: MODEL1310110063#
reactant: MODEL1310110063#
product: MODEL1310110063#
is described by: ECO:0000000

metaM ksi deg27 l
type: Species
has only substance units: false
is: HMDB00143
constant: false
is: CHEBI:12936
initial amount: NaN
initial concentration: 1.0
is: SBO:0000247
notes: FORMULA: C104H169N7O88S4 CHARGE: -4
name: keratan sulfate I, degradation product 27
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110063#_cbb5d4b9_5e77_4449_a63d_989eae88893a
boundary condition: true
constant: false
type: Species
has only substance units: false
initial concentration: NaN
is: Q9Y633
is encoded by: hsa:5136
initial amount: NaN
name: PDE1A
is: SBO:0000252

metaR r2052
type: Reaction
fast: false
reactant: MODEL1310110063#
product: MODEL1310110063#
reversible: false
modifier: MODEL1310110063#
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
kinetic law: MODEL1310110063#
is: SBO:0000185
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.15
is described by: ECO:0000000

metaM dudp m
notes: FORMULA: C9H11N2O11P2 CHARGE: -3 INCHI: InChI=1S/C9H14N2O11P2/c12-5-3-8(11-2-1-7(13)10-9(11)14)21-6(5)4-20-24(18,19)22-23(15,16)17/h1-2,5-6,8,12H,3-4H2,(H,18,19)(H,10,13,14)(H2,15,16,17)/p-3/t5-,6+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00768 EHMN_ABBREVIATION: C01346
initial amount: NaN
is: HMDB01000
is: CHEBI:60471
constant: false
has only substance units: false
name: dUDP(3-)
initial concentration: 1.0
type: Species
is: SBO:0000247
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110063#_3b617de0_042f_44d6_ac40_32d396deb000
constant: false
type: Species
has only substance units: false
initial amount: NaN
boundary condition: true
name: _AA614647_1_c
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:AA614647

metaM phyt e
is: HMDB00801
initial concentration: 1.0
is: SBO:0000247
initial amount: NaN
boundary condition: false
constant: false
type: Species
has only substance units: false
notes: FORMULA: C20H39O2 CHARGE: -1 INCHI: InChI=1S/C20H40O2/c1-16(2)9-6-10-17(3)11-7-12-18(4)13-8-14-19(5)15-20(21)22/h16-19H,6-15H2,1-5H3,(H,21,22)/p-1 EHMN_ABBREVIATION: C01607
is: CHEBI:37257
name: phytanate

http://identifiers.org/biomodels.db/MODEL1310110063#_eeec1186_e6fc_4346_b1d2_8ca5962c9de5
is: P19440
boundary condition: true
name: GGT1
is encoded by: hsa:2678
initial amount: NaN
constant: false
has only substance units: false
is: SBO:0000252
type: Species
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110063#_d7e23ba1_79ae_4c29_a3ac_ea17c5d34d7b
initial concentration: NaN
is encoded by: hsa:55350
boundary condition: true
is: SBO:0000252
has only substance units: false
type: Species
constant: false
initial amount: NaN
name: VNN3

http://identifiers.org/biomodels.db/MODEL1310110063#_e121b04e_0d71_4b3a_b8fa_b4186a045325
is: SBO:0000252
name: _AA576959_1_c
is encoded by: hsa:AA576959
constant: false
initial concentration: NaN
type: Species
has only substance units: false
initial amount: NaN
boundary condition: true

metaR DM pe hs LPAREN r RPAREN
kinetic law: MODEL1310110063#
reactant: MODEL1310110063#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 0 AUTHORS: PMID: 17173541 NOTES:added during gap-filling, no evidence for such a reaction. only assumed.
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: demand reaction for pe_hs[r]
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110063#_05069ed6_c25b_4b27_998e_f11eb27f65e7
initial amount: NaN
name: MGST3
is: O14880
is encoded by: hsa:4259
has only substance units: false
constant: false
type: Species
is: SBO:0000252
boundary condition: true
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110063#_45bd73c5_bf25_43a2_8387_654679116e7d
initial amount: NaN
type: Species
is: SBO:0000252
initial concentration: NaN
is encoded by: hsa:51079
has only substance units: false
boundary condition: true
is: Q9P0J0
constant: false
name: NDUFA13

metaR FAOXTC101TC102m
kinetic law: MODEL1310110063#
product: MODEL1310110063#
reactant: MODEL1310110063#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation trans(C10:1-->C10:2)m
type: Reaction

metaR FAOXC8C6m
kinetic law: MODEL1310110063#
product: MODEL1310110063#
reactant: MODEL1310110063#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C8-->C6)m
type: Reaction

metaM thcholstoic c
is: HMDB03873
initial amount: NaN
name: 3alpha,7alpha,12alpha-Trihydroxy-5beta-cholestanoate
constant: false
has only substance units: false
initial concentration: 1.0
notes: FORMULA: C27H45O5 CHARGE: -1 INCHI: InChI=1S/C27H46O5/c1-15(6-5-7-16(2)25(31)32)19-8-9-20-24-21(14-23(30)27(19,20)4)26(3)11-10-18(28)12-17(26)13-22(24)29/h15-24,28-30H,5-14H2,1-4H3,(H,31,32)/t15-,16?,17+,18-,19-,20+,21+,22-,23+,24+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01340 EHMN_ABBREVIATION: C04722
is: SBO:0000247
type: Species
boundary condition: false
is: CHEBI:18402

http://identifiers.org/biomodels.db/MODEL1310110063#_cbafc452_b780_45c0_bf23_dc95603880ac
name: CEPT1
initial amount: NaN
constant: false
has only substance units: false
is: B3KN25
is: SBO:0000252
boundary condition: true
type: Species
is encoded by: hsa:10390
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110063#_metaR_EX_s2l2fn2m2masn_LPAREN_e_RPAREN_
kinetic law: MODEL1310110063#
reactant: MODEL1310110063#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: PA6 exchange
type: Reaction

metaM lnlncg e
has only substance units: false
name: gamma-linolenate
boundary condition: false
initial amount: NaN
is: SBO:0000247
is: CHEBI:32391
constant: false
type: Species
is: HMDB03073
notes: FORMULA: C18H29O2 CHARGE: -1 INCHI: InChI=1S/C18H30O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20/h6-7,9-10,12-13H,2-5,8,11,14-17H2,1H3,(H,19,20)/p-1/b7-6-,10-9-,13-12-
initial concentration: 1.0

metaR r1946
modifier: MODEL1310110063#
fast: false
reversible: false
name: Y+LAT2 Utilized transport
type: Reaction
reactant: MODEL1310110063#
product: MODEL1310110063#
is: SBO:0000185
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
kinetic law: MODEL1310110063#
is described by: ECO:0000000

metaR CSPG Etly
name: chondroitin sulfate E transport, extracellular to lysosome
fast: false
product: MODEL1310110063#
reversible: false
reactant: MODEL1310110063#
kinetic law: MODEL1310110063#
is: SBO:0000185
type: Reaction
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 2 AUTHORS: NOTES:

metaR FAOXC185C164m
kinetic law: MODEL1310110063#
product: MODEL1310110063#
reactant: MODEL1310110063#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C18:5-->C16:4)m
type: Reaction

metaM leuktrD4 c
is: HMDB03080
notes: FORMULA: C25H39N2O6S CHARGE: -1 INCHI: InChI=1S/C25H40N2O6S/c1-2-3-4-5-6-7-8-9-10-11-12-13-16-22(21(28)15-14-17-23(29)30)34-19-20(26)25(33)27-18-24(31)32/h6-7,9-13,16,20-22,28H,2-5,8,14-15,17-19,26H2,1H3,(H,27,33)(H,29,30)(H,31,32)/b7-6-,10-9-,12-11+,16-13+/t20-,21-,22+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01664 EHMN_ABBREVIATION: C05951
is: SBO:0000247
constant: false
initial concentration: 1.0
type: Species
initial amount: NaN
has only substance units: false
is: CHEBI:28666
boundary condition: false
name: Leukotriene D4

http://identifiers.org/biomodels.db/MODEL1310110063#_eeff2368_7021_4142_94ad_39e6b79fa6ee
initial concentration: NaN
initial amount: NaN
is: SBO:0000252
constant: false
type: Species
name: _NOS2A_1_e
is encoded by: hsa:NOS2A
boundary condition: true
has only substance units: false

metaR LEUKTRD4tr
name: leukotriene intracellular transport
fast: false
product: MODEL1310110063#
kinetic law: MODEL1310110063#
type: Reaction
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: NOTES:unknown mechanism, presumed diffusion NJ
is described by: ECO:0000000
reactant: MODEL1310110063#
reversible: true

metaR C18OHc
kinetic law: MODEL1310110063#
product: MODEL1310110063#
reactant: MODEL1310110063#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: production of 3-hydroxyoctadecanoylcarnitine
type: Reaction

metaR FAOXC16080m
reactant: MODEL1310110063#
modifier: MODEL1310110063#
kinetic law: MODEL1310110063#
is version of: http://identifiers.org/ec-code/1.3.99.3
notes: GENE_ASSOCIATION: (35.1) or (34.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.74 Confidence Level: 4 AUTHORS: NOTES:_4 rounds of beta ox c16:0 -> c8:0, 4 step FAO lumped for 2 rounds also includes EC 1.1.1.35, 1.1.1.211, 1.3.3.6, 4.2.1.17, 4.2.1.74 NJ
is described by: ECO:0000269
type: Reaction
is version of: http://identifiers.org/ec-code/1.3.8.1
fast: false
name: Beta oxidation of long chain fatty acid
is: SBO:0000176
reversible: false
product: MODEL1310110063#

http://identifiers.org/biomodels.db/MODEL1310110063#_eb9b950d_4517_48dc_9447_8ef3a40d5fdc
is encoded by: hsa:26289
type: Species
has only substance units: false
boundary condition: true
constant: false
initial concentration: NaN
name: AK5
is: SBO:0000252
initial amount: NaN

metaM co2 e
is: CHEBI:16526
notes: FORMULA: CO2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00021 EHMN_ABBREVIATION: C00011
is: C00011
boundary condition: false
has only substance units: false
constant: false
is: SBO:0000247
is: HMDB01967
initial concentration: 1.0
type: Species
name: CO2
initial amount: NaN

metaM cmp e
name: CMP(2-)
is: HMDB00095
boundary condition: false
has only substance units: false
constant: false
notes: FORMULA: C9H12N3O8P CHARGE: -2 INCHI: InChI=1S/C9H14N3O8P/c10-5-1-2-12(9(15)11-5)8-7(14)6(13)4(20-8)3-19-21(16,17)18/h1-2,4,6-8,13-14H,3H2,(H2,10,11,15)(H2,16,17,18)/p-2/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00060 EHMN_ABBREVIATION: C00055
is: SBO:0000247
is: CHEBI:60377
initial concentration: 1.0
type: Species
initial amount: NaN

metaR r2392
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172 NOTES:
kinetic law: MODEL1310110063#
reactant: MODEL1310110063#
type: Reaction
is described by: ECO:0000000
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
is: SBO:0000185
fast: false
reversible: false
product: MODEL1310110063#

metaR r0975
kinetic law: MODEL1310110063#
product: MODEL1310110063#
name: Facilitated diffusion
reversible: false
fast: false
type: Reaction
reactant: MODEL1310110063#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:1260500 NOTES:
is: SBO:0000185

metaR EX C05965 LPAREN e RPAREN
kinetic law: MODEL1310110063#
reactant: MODEL1310110063#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 12(S)-HPETE(1-) exchange
type: Reaction

metaR RE1233C
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.6.1.64
type: Reaction
is described by: ECO:0000000
modifier: MODEL1310110063#
product: MODEL1310110063#
fast: false
reactant: MODEL1310110063#
notes: GENE_ASSOCIATION: (883.1) SUBSYSTEM: Tryptophan metabolism EC Number: 2.6.1.7 Confidence Level: 0 AUTHORS: PMID:10756023 NOTES:IT - removed H[c] on right hand side
kinetic law: MODEL1310110063#
reversible: true
name: RE1233

http://identifiers.org/biomodels.db/MODEL1310110063#_05317b4e_a321_417c_b9bb_7e2f20df9f5b
has only substance units: false
is: SBO:0000252
type: Species
constant: false
is encoded by: hsa:U52111
boundary condition: true
name: _U52111_1_c
initial amount: NaN
initial concentration: NaN

metaM ksi deg38 l
is: HMDB00143
name: keratan sulfate I, degradation product 38
constant: false
boundary condition: false
is: SBO:0000247
notes: FORMULA: C54H91N3O41 CHARGE: 0
is: CHEBI:12936
has only substance units: false
initial amount: NaN
initial concentration: 1.0
type: Species

metaM biocyt e
has only substance units: false
initial amount: NaN
initial concentration: 1.0
is: http://identifiers.org/pubchem.compound/7886
boundary condition: false
is: HMDB03134
type: Species
name: Biocytin
constant: false
is: SBO:0000247
is: C05552
notes: FORMULA: C16H28N4O4S CHARGE: 0 INCHI: InChI=1/C16H28N4O4S/c17-10(15(22)23)5-3-4-8-18-13(21)7-2-1-6-12-14-11(9-25-12)19-16(24)20-14/h10-12,14H,1-9,17H2,(H,18,21)(H,22,23)(H2,19,20,24)/t10-,11-,12-,14-/m0/s1 EHMN_ABBREVIATION: C05552

http://identifiers.org/biomodels.db/MODEL1310110063#_a8d5acf7_7d43_4ea6_b6bc_8e8b962b1e70
constant: false
boundary condition: true
initial amount: NaN
is: P21399
name: ACO1
is: SBO:0000252
has only substance units: false
type: Species
initial concentration: NaN
is encoded by: hsa:48

metaM duri e
initial concentration: 1.0
is: CHEBI:16450
initial amount: NaN
is: C00526
name: Deoxyuridine
constant: false
is: HMDB00012
notes: FORMULA: C9H12N2O5 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00410 EHMN_ABBREVIATION: C00526
is: SBO:0000247
has only substance units: false
type: Species
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110063#_399c52ee_132f_4b07_8d53_765aca6fd167
constant: false
is encoded by: hsa:2271
boundary condition: true
initial amount: NaN
name: FH
has only substance units: false
type: Species
is: SBO:0000252
is: P07954
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110063#_3a033f21_dab6_4a8b_8e5e_cb119b03e461
is: SBO:0000252
is encoded by: hsa:79369
constant: false
has only substance units: false
initial amount: NaN
is: Q9C0J1
name: B3GNT4
boundary condition: true
type: Species
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110063#_f10c5cde_523a_4324_a1e5_0e3d4a56e5b6
boundary condition: true
has only substance units: false
is: SBO:0000252
constant: false
initial amount: NaN
type: Species
name: PKLR
is encoded by: hsa:5313
is: P30613
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110063#_29c2476a_69c8_4cea_bea7_bae0d6fc4b05
type: Species
initial amount: NaN
constant: false
is: SBO:0000252
is: P13196
initial concentration: NaN
boundary condition: true
is encoded by: hsa:211
name: ALAS1
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110063#_a1ff540b_99ce_451c_98d6_f850051625c7
constant: false
initial concentration: NaN
is: SBO:0000252
initial amount: NaN
boundary condition: true
is: B7Z3U6
is encoded by: hsa:476
name: ATP1A1
has only substance units: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110063#_e4e402df_3c33_4d31_a8e5_3e17e4958645
is: SBO:0000252
name: MECR
initial amount: NaN
boundary condition: true
is encoded by: hsa:51102
type: Species
is: Q9BV79
initial concentration: NaN
constant: false
has only substance units: false

metaM pect e
boundary condition: false
has only substance units: false
is: SBO:0000247
initial concentration: 1.0
is: HMDB03402
initial amount: NaN
type: Species
notes: FORMULA: C2535H3509O2535 CHARGE: -1
constant: false
name: pectins

metaR r0142
kinetic law: MODEL1310110063#
fast: false
is: SBO:0000176
type: Reaction
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (AV717590.1) or (953.1) or (956.1) or (377841.1) SUBSYSTEM: Methionine and cysteine metabolism EC Number: 1.8.3.1 Confidence Level: 0 AUTHORS: PMID:12763039,PMID:16475804,PMID:17459792 NOTES:
product: MODEL1310110063#
reactant: MODEL1310110063#
reversible: false
is version of: http://identifiers.org/ec-code/3.6.1.5
modifier: MODEL1310110063#
name: Sulfite:oxygen oxidoreductase Sulfur metabolism EC:1.8.3.1

metaR PRISTCOAtcx
kinetic law: MODEL1310110063#
product: MODEL1310110063#
reactant: MODEL1310110063#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of pristanoylcoa from cytosol to peroxisomes.
type: Reaction

metaR r0974
kinetic law: MODEL1310110063#
product: MODEL1310110063#
is described by: ECO:0000000
reversible: true
fast: false
name: Active transport
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:10334869,PMID:12603856,PMID:17024033,PMID:9516450 NOTES:
reactant: MODEL1310110063#
is: SBO:0000185
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110063#_013d14c5_714e_415b_a69e_e2c19418456e
initial amount: NaN
has only substance units: false
boundary condition: true
constant: false
is: Q8N0W3
is: SBO:0000252
is encoded by: hsa:197258
initial concentration: NaN
name: FUK
type: Species

metaR HSD3B7P
fast: false
reactant: MODEL1310110063#
modifier: MODEL1310110063#
kinetic law: MODEL1310110063#
is: SBO:0000176
notes: GENE_ASSOCIATION: (80270.1) SUBSYSTEM: Bile acid synthesis EC Number: Confidence Level: 4 AUTHORS: NOTES:
is version of: http://identifiers.org/ec-code/1.1.1.181
is described by: ECO:0000269
name: hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 7
reversible: false
type: Reaction
product: MODEL1310110063#

metaM 2obut c
boundary condition: false
type: Species
name: 2-Oxobutanoate
is: HMDB00005
notes: FORMULA: C4H5O3 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00108 EHMN_ABBREVIATION: C00109
has only substance units: false
is: CHEBI:16763
is: SBO:0000247
initial amount: NaN
is: C00109
constant: false
initial concentration: 1.0

metaR r1378
product: MODEL1310110063#
type: Reaction
name: S-(hydroxymethyl)glutathione dehydrogenase Methane metabolism EC:1.1.1.284
is: SBO:0000176
is described by: ECO:0000000
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 1.1.1.284 Confidence Level: 0 AUTHORS: PMID:18288723 NOTES:
reactant: MODEL1310110063#
kinetic law: MODEL1310110063#
fast: false

http://identifiers.org/biomodels.db/MODEL1310110063#_df8e51aa_cb9b_483f_9ad4_e41a41131f5f
is: SBO:0000252
has only substance units: false
is encoded by: hsa:4541
type: Species
initial amount: NaN
boundary condition: true
name: ND6
constant: false
initial concentration: NaN
is: Q7GXZ1

http://identifiers.org/biomodels.db/MODEL1310110063#_28c77b1c_a195_4884_8de7_d1addcf924d4
name: NDUFA2
boundary condition: true
has only substance units: false
initial amount: NaN
initial concentration: NaN
constant: false
type: Species
is: SBO:0000252
is encoded by: hsa:4695
is: O43678

metaR HISTAtu
kinetic law: MODEL1310110063#
is: SBO:0000185
name: Histamine uniport
product: MODEL1310110063#
reversible: true
fast: false
notes: GENE_ASSOCIATION: (6581.1) or (6582.2) or (6582.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12883891 NOTES:SAB electrogenic, Na indepdendent & rev NJ
reactant: MODEL1310110063#
type: Reaction
is described by: ECO:0000269
modifier: MODEL1310110063#

metaM xol7aone c
notes: FORMULA: C27H44O2 CHARGE: 0 INCHI: InChI=1S/C27H44O2/c1-17(2)7-6-8-18(3)21-9-10-22-25-23(12-14-27(21,22)5)26(4)13-11-20(28)15-19(26)16-24(25)29/h15,17-18,21-25,29H,6-14,16H2,1-5H3/t18-,21-,22+,23+,24-,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01464 EHMN_ABBREVIATION: C05455
is: HMDB01993
initial concentration: 1.0
constant: false
boundary condition: false
initial amount: NaN
name: 7alpha-hydroxycholest-4-en-3-one
is: SBO:0000247
is: CHEBI:17899
type: Species
has only substance units: false

metaR r0973
is described by: ECO:0000000
is: SBO:0000185
kinetic law: MODEL1310110063#
name: Facilitated diffusion
product: MODEL1310110063#
fast: false
type: Reaction
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:15975683 NOTES:
reactant: MODEL1310110063#

http://identifiers.org/biomodels.db/MODEL1310110063#_29b63b8f_847d_42e7_810e_b1f4bdae0491
constant: false
is encoded by: hsa:4701
initial concentration: NaN
has only substance units: false
name: NDUFA7
is: Q6FG42
is: SBO:0000252
boundary condition: true
initial amount: NaN
type: Species

metaM ksi deg31 l
is: HMDB01354
boundary condition: false
has only substance units: false
is: CHEBI:57455
initial concentration: 1.0
constant: false
initial amount: NaN
notes: FORMULA: C90H148N6O72S2 CHARGE: -2
name: keratan sulfate I, degradation product 31
type: Species
is: SBO:0000247

metaR S6T7g
notes: GENE_ASSOCIATION: (23563.2) or (9435.1) or (23563.1) or (10164.1) or (4166.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: Confidence Level: 4 AUTHORS: PMID:10330415,PMID:10491328,PMID:10913333,PMID:11278593,PMID:12403612,PMID:12855678,PMID:9722682 NOTES:NCD
is: SBO:0000176
kinetic law: MODEL1310110063#
is described by: ECO:0000000
name: galactose/N-acetylglucosamine 6-O-sulfotransferase, Golgi apparatus
type: Reaction
product: MODEL1310110063#
reversible: false
reactant: MODEL1310110063#
modifier: MODEL1310110063#
fast: false

metaR FAOXC103C102m
kinetic law: MODEL1310110063#
product: MODEL1310110063#
reactant: MODEL1310110063#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C10:3-->C10:2)m
type: Reaction

metaR PSSA1 hs
kinetic law: MODEL1310110063#
reactant: MODEL1310110063#
is: SBO:0000176
is described by: ECO:0000269
fast: false
is version of: http://identifiers.org/ec-code/2.7.8.29
name: Phosphatidylserine synthase homo sapiens
product: MODEL1310110063#
reversible: true
type: Reaction
notes: GENE_ASSOCIATION: (9791.1) SUBSYSTEM: Glycerophospholipid metabolism EC Number: 2.7.8.8 Confidence Level: 4 AUTHORS: NOTES:phosphatidylcholine as substrate NJ
modifier: MODEL1310110063#

metaM co2 c
name: CO2
initial amount: NaN
constant: false
is: SBO:0000247
type: Species
is: C00011
is: HMDB01967
is: CHEBI:3313
notes: FORMULA: CO2 CHARGE: 0
initial concentration: 1.0
has only substance units: false
boundary condition: false

metaM cmp c
is: C00055
initial amount: NaN
is: CHEBI:60377
constant: false
is: SBO:0000247
is: HMDB00095
type: Species
notes: FORMULA: C9H12N3O8P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00060 EHMN_ABBREVIATION: C00055
initial concentration: 1.0
has only substance units: false
boundary condition: false
name: CMP

metaR EX leuktrC4 LPAREN e RPAREN
kinetic law: MODEL1310110063#
reactant: MODEL1310110063#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Leukotriene C4 exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110063#_868360d7_51f0_4310_b65c_f42b20643eb2
name: ATG9B
is: SBO:0000252
constant: false
initial amount: NaN
has only substance units: false
is: Q674R7
boundary condition: true
is encoded by: hsa:285973
initial concentration: NaN
type: Species

metaM n2m2nmasn l
initial concentration: 1.0
initial amount: NaN
is: C04946
constant: false
is: SBO:0000247
name: N-Acetyl-beta-D-glucosaminyl-1,2-alpha-D-mannosyl-1,3-(N-acetyl-beta-D-glucosaminyl-1,2-alpha-D-mannosyl-1,6)-(N-acetyl-beta-D-glucosaminyl-1,4)-beta-D-mannosyl-1,4-N-acetyl-beta-D-glucosaminyl-R
has only substance units: false
notes: FORMULA: C58H96N5O40X CHARGE: 0
boundary condition: false
type: Species

metaR EX 6thf LPAREN e RPAREN
kinetic law: MODEL1310110063#
reactant: MODEL1310110063#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: hexaglutamyl folate (THF) exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110063#_1a83283b_8aae_4e50_b701_24c277aea427
has only substance units: false
is: SBO:0000252
is encoded by: hsa:2678
boundary condition: true
constant: false
type: Species
initial concentration: NaN
name: GGT1
initial amount: NaN

metaR G14T9g
is described by: ECO:0000000
modifier: MODEL1310110063#
notes: GENE_ASSOCIATION: (8703.1) or (2683.1) or (8704.2) or (8704.1) or (9334.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.38 Confidence Level: 4 AUTHORS: PMID:12512857,PMID:1903938,PMID:3094506,PMID:3144273,PMID:9405390,PMID:9435216 NOTES:Keratan sulfate I biosynthesis NCD
fast: false
kinetic law: MODEL1310110063#
type: Reaction
product: MODEL1310110063#
reactant: MODEL1310110063#
is version of: http://identifiers.org/ec-code/2.4.1.38
is version of: http://identifiers.org/ec-code/2.4.1.22
name: beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase, Golgi
is version of: http://identifiers.org/ec-code/2.4.1.90
is: SBO:0000176
reversible: false

metaR BDMT U
name: GDPmannose:chitobiosyldiphosphodolichol beta-D-mannosyltransferase (uterus)
is version of: http://identifiers.org/ec-code/2.4.1.142
type: Reaction
fast: false
reactant: MODEL1310110063#
is described by: ECO:0000000
product: MODEL1310110063#
kinetic law: MODEL1310110063#
notes: GENE_ASSOCIATION: (56052.1) SUBSYSTEM: N-glycan synthesis EC Number: 2.4.1.142 Confidence Level: 0 AUTHORS: NOTES:NCD
modifier: MODEL1310110063#
is: SBO:0000176
reversible: false

metaM CE5786 e
initial amount: NaN
has only substance units: false
type: Species
boundary condition: false
name: kinetensin
is: HMDB02710
initial concentration: 1.0
is: CHEBI:27485
constant: false
notes: FORMULA: C56H87N17O11 CHARGE: 2 INCHI: InChI=1/C56H85N17O11/c1-6-32(4)45(57)52(81)66-33(5)46(75)67-38(15-10-22-63-55(58)59)47(76)68-39(16-11-23-64-56(60)61)48(77)71-42(28-36-29-62-30-65-36)53(82)73-24-12-17-44(73)51(80)70-41(27-35-18-20-37(74)21-19-35)49(78)69-40(26-34-13-8-7-9-14-34)50(79)72-43(54(83)84)25-31(2)3/h7-9,13-14,18-21,29-33,38-45,74H,6,10-12,15-17,22-28,57H2,1-5H3,(H,62,65)(H,66,81)(H,67,75)(H,68,76)(H,69,78)(H,70,80)(H,71,77)(H,72,79)(H,83,84)(H4,58,59,63)(H4,60,61,64)/p+2/t32-,33+,38-,39+,40-,41+,42-,43+,44-,45-/m1/s1 EHMN_ABBREVIATION: CE5786
is: SBO:0000247

metaM ksii core2 pre7 g
type: Species
name: keratan sulfate II biosynthesis, precursor 7
notes: FORMULA: C67H108N5O51SX CHARGE: -2
is: CHEBI:58053
is: SBO:0000247
is: HMDB00175
initial concentration: 1.0
constant: false
has only substance units: false
initial amount: NaN
is: C00130
boundary condition: false

metaM HC02206 c
initial amount: NaN
notes: FORMULA: C20H31O4 CHARGE: -1 INCHI: InChI=1S/C20H32O4/c1-2-3-6-9-17(21)14-12-16-13-15-19(22)18(16)10-7-4-5-8-11-20(23)24/h12-14,17-18,21H,2-11,15H2,1H3,(H,23,24)/p-1/b14-12+/t17-,18+/m0/s1 EHMN_ABBREVIATION: C04686
constant: false
name: prostaglandin C1(1-)
is: CHEBI:57399
has only substance units: false
is: SBO:0000247
type: Species
boundary condition: false
initial concentration: 1.0

metaM CE2432 m
type: Species
initial concentration: 1.0
name: trans-2-cis,cis-5,8-tetradecatrienoyl-CoA
initial amount: NaN
has only substance units: false
boundary condition: false
notes: FORMULA: C35H52N7O17P3S CHARGE: -4 INCHI: InChI=1/C35H56N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-26(44)63-19-18-37-25(43)16-17-38-33(47)30(46)35(2,3)21-56-62(53,54)59-61(51,52)55-20-24-29(58-60(48,49)50)28(45)34(57-24)42-23-41-27-31(36)39-22-40-32(27)42/h8-9,11-12,14-15,22-24,28-30,34,45-46H,4-7,10,13,16-21H2,1-3H3,(H,37,43)(H,38,47)(H,51,52)(H,53,54)(H2,36,39,40)(H2,48,49,50)/p-4/b9-8-,12-11-,15-14+/t24-,28+,29+,30u,34-/m0/s1 EHMN_ABBREVIATION: CE2432
is: CHEBI:57795
is: SBO:0000247
constant: false

metaM dttp c
is: HMDB01342
is: CHEBI:37568
is: C00459
constant: false
name: dTTP
initial amount: NaN
has only substance units: false
notes: FORMULA: C10H13N2O14P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00368 EHMN_ABBREVIATION: C00459
initial concentration: 1.0
boundary condition: false
is: SBO:0000247
type: Species

http://identifiers.org/biomodels.db/MODEL1310110063#_63bfa1c5_af1a_4df1_bdcd_6a5de3c93002
has only substance units: false
is encoded by: hsa:280
is: SBO:0000252
name: AMY2B
type: Species
constant: false
is: P19961
boundary condition: true
initial amount: NaN
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110063#_f6734112_6484_4778_86f5_9a239bada26f
constant: false
type: Species
is encoded by: hsa:AF116616
initial amount: NaN
is: SBO:0000252
boundary condition: true
has only substance units: false
initial concentration: NaN
name: _AF116616_1_m

http://identifiers.org/biomodels.db/MODEL1310110063#_f4a9a7d2_277d_4b09_8079_c1c37b5d31b7
name: PAPSS1
is encoded by: hsa:9061
has only substance units: false
is: O43252
is: SBO:0000252
boundary condition: true
type: Species
initial concentration: NaN
constant: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110063#_6ec68996_0064_4c73_aa9c_b13fa2603f49
boundary condition: true
is: SBO:0000252
name: NDUFS1
constant: false
initial concentration: NaN
has only substance units: false
is encoded by: hsa:4719
is: P28331
initial amount: NaN
type: Species

metaR DOPASULT
type: Reaction
name: Dopamine Sulfotransferase
notes: GENE_ASSOCIATION: (6799.1) or (6817.3) or (6799.2) or (6818.2) or (6817.2) or (6818.1) or (6817.1) or (6817.4) or (6818.3) or (6817.5) SUBSYSTEM: Tyrosine metabolism EC Number: 2.8.2.1 Confidence Level: 4 AUTHORS: PMID:11535246,PMID:15293241 NOTES:RS/TV (6/14/2005)
kinetic law: MODEL1310110063#
fast: false
is version of: http://identifiers.org/ec-code/2.8.2.1
is: SBO:0000176
modifier: MODEL1310110063#
reactant: MODEL1310110063#
is described by: ECO:0000269
reversible: false
product: MODEL1310110063#

metaR RE2660C
type: Reaction
name: RE2660
product: MODEL1310110063#
reactant: MODEL1310110063#
reversible: true
is: SBO:0000176
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Tetrahydrobiopterin metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:9647871 NOTES:
is described by: ECO:0000000
kinetic law: MODEL1310110063#

metaR r2391
product: MODEL1310110063#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172 NOTES:
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
type: Reaction
is described by: ECO:0000000
kinetic law: MODEL1310110063#
reversible: false
reactant: MODEL1310110063#
is: SBO:0000185
fast: false

metaM ppi x
notes: FORMULA: HO7P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00023 EHMN_ABBREVIATION: C00013
name: Diphosphate
initial concentration: 1.0
boundary condition: false
constant: false
has only substance units: false
is: HMDB00250
is: SBO:0000247
is: CHEBI:33019
is: C00013
type: Species
initial amount: NaN

metaM oxa m
name: oxalate(2-)
has only substance units: false
initial concentration: 1.0
type: Species
is: SBO:0000247
notes: FORMULA: C2O4 CHARGE: -2 INCHI: InChI=1S/C2H2O4/c3-1(4)2(5)6/h(H,3,4)(H,5,6)/p-2 HEPATONET_1.0_ABBREVIATION: HC00195 EHMN_ABBREVIATION: C00209
constant: false
is: CHEBI:30623
is: HMDB02329
initial amount: NaN
boundary condition: false

metaM 4ppcys c
notes: FORMULA: C12H20N2O9PS CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC01276 EHMN_ABBREVIATION: C04352
is: CHEBI:59458
initial concentration: 1.0
initial amount: NaN
constant: false
has only substance units: false
boundary condition: false
is: C04352
name: N-((R)-4-Phosphopantothenoyl)-L-cysteine
type: Species
is: HMDB01117
is: SBO:0000247

metaR FUCASE2ly
notes: GENE_ASSOCIATION: (2517.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.51 Confidence Level: 4 AUTHORS: PMID:11870229,PMID:1769200,PMID:2803312,PMID:2983333 NOTES:NCD
modifier: MODEL1310110063#
is version of: http://identifiers.org/ec-code/3.2.1.51
is described by: ECO:0000000
type: Reaction
product: MODEL1310110063#
kinetic law: MODEL1310110063#
name: alpha-fucosidase, lysosomal
reactant: MODEL1310110063#
reversible: false
fast: false
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110063#_61a78ad6_0bec_4f60_b870_883d4884e3f7
is: SBO:0000252
is: Q6YFQ2
has only substance units: false
is encoded by: hsa:125965
type: Species
boundary condition: true
constant: false
initial amount: NaN
name: COX6B2
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110063#_2a9d8974_5937_45d0_b3ba_931c6c88142b
boundary condition: true
constant: false
initial amount: NaN
initial concentration: NaN
is: SBO:0000252
type: Species
is encoded by: hsa:515
has only substance units: false
name: ATP5F1

metaR C102CPT1
kinetic law: MODEL1310110063#
product: MODEL1310110063#
reactant: MODEL1310110063#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: production of decadienoylcarnitine
type: Reaction

metaM 3docopencoa m
is: SBO:0000247
is: http://identifiers.org/pubchem.compound/24892790
initial amount: NaN
constant: false
type: Species
name: 3,7,10,13,16-docosapentenoylcoa
has only substance units: false
initial concentration: 1.0
notes: FORMULA: C43H64N7O17P3S CHARGE: -4
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110063#_bfa40d36_c37a_4523_bc03_3e85f3d97e04
initial amount: NaN
name: ND1
boundary condition: true
type: Species
is encoded by: hsa:4535
is: Q85KV6
initial concentration: NaN
constant: false
is: SBO:0000252
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110063#_d3855162_77b8_48b0_9b4f_bba4c165c23e
name: COX6C
is: P09669
constant: false
has only substance units: false
is encoded by: hsa:1345
type: Species
initial amount: NaN
is: SBO:0000252
boundary condition: true
initial concentration: NaN

metaR IDOAASE2ly
fast: false
type: Reaction
product: MODEL1310110063#
modifier: MODEL1310110063#
reversible: false
kinetic law: MODEL1310110063#
is version of: http://identifiers.org/ec-code/3.2.1.76
name: alpha-L-iduronidase, lysosomal
is: SBO:0000176
notes: GENE_ASSOCIATION: (3425.1) SUBSYSTEM: Heparan sulfate degradation EC Number: 3.2.1.76 Confidence Level: 4 AUTHORS: PMID:1946389,PMID:2470345 NOTES:NCD
reactant: MODEL1310110063#
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110063#_dd45f916_30a5_4043_9904_1ffd054ee2cd
constant: false
name: SLC35A1
is: P78382
initial concentration: NaN
has only substance units: false
initial amount: NaN
type: Species
boundary condition: true
is: SBO:0000252
is encoded by: hsa:10559

metaM mthgxl c
notes: FORMULA: C3H4O2 CHARGE: 0 INCHI: InChI=1S/C3H4O2/c1-3(5)2-4/h2H,1H3 HEPATONET_1.0_ABBREVIATION: HC00425 EHMN_ABBREVIATION: C00546
initial amount: NaN
is: CHEBI:17158
initial concentration: 1.0
is: SBO:0000247
has only substance units: false
is: HMDB01167
type: Species
constant: false
boundary condition: false
name: methylglyoxal

metaM tdchola x
type: Species
has only substance units: false
is: SBO:0000247
initial concentration: 1.0
is: HMDB00951
initial amount: NaN
is: CHEBI:9407
notes: FORMULA: C26H45NO6S CHARGE: 0 INCHI: InChI=1S/C26H45NO6S/c1-16(4-7-23(30)27-12-13-34(31,32)33)19-5-6-20-24-21(9-11-26(19,20)3)25(2)10-8-18(28)14-17(25)15-22(24)29/h16-22,24,28-29H,4-15H2,1-3H3,(H,27,30)(H,31,32,33)/p-1/t16-,17+,18-,19-,20+,21+,22-,24+,25+,26-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01471 EHMN_ABBREVIATION: C05465
name: taurochenodeoxycholate
constant: false
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110063#_d3164c12_ad85_4bfe_82bd_609b4993b119
initial amount: NaN
constant: false
has only substance units: false
initial concentration: NaN
boundary condition: true
type: Species
is encoded by: hsa:8867
is: SBO:0000252
is: O43426
name: SYNJ1

metaR r1377
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 4.4.1.22 Confidence Level: 0 AUTHORS: NOTES:
type: Reaction
is: SBO:0000176
is described by: ECO:0000000
reactant: MODEL1310110063#
name: S-(hydroxymethyl)glutathione synthase Methane metabolism EC:4.4.1.22
fast: false
product: MODEL1310110063#
reversible: true
kinetic law: MODEL1310110063#

http://identifiers.org/biomodels.db/MODEL1310110063#_54073e58_b4c8_45dd_a6c1_eedd69666376
is: SBO:0000252
initial amount: NaN
name: GK2
is encoded by: hsa:2712
initial concentration: NaN
boundary condition: true
is: Q14410
type: Species
has only substance units: false
constant: false

metaM ppa c
is: SBO:0000247
boundary condition: false
type: Species
constant: false
has only substance units: false
name: propionate
notes: FORMULA: C3H5O2 CHARGE: -1 INCHI: InChI=1S/C3H6O2/c1-2-3(4)5/h2H2,1H3,(H,4,5)/p-1 HEPATONET_1.0_ABBREVIATION: HC00158 EHMN_ABBREVIATION: C00163
initial amount: NaN
is: CHEBI:17272
initial concentration: 1.0
is: HMDB00237

metaR FAOXTC102C101m
kinetic law: MODEL1310110063#
product: MODEL1310110063#
reactant: MODEL1310110063#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation trans(C10:2-->C10:1)m
type: Reaction

metaR EX tre LPAREN e RPAREN
kinetic law: MODEL1310110063#
reactant: MODEL1310110063#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Trehalose exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110063#_45cc6e08_99e7_428d_a441_8162d5798dc9
is: SBO:0000252
is: Q16795
constant: false
has only substance units: false
initial concentration: NaN
name: NDUFA9
is encoded by: hsa:4704
type: Species
initial amount: NaN
boundary condition: true

metaR SERDGLYexR
is: SBO:0000185
product: MODEL1310110063#
is described by: ECO:0000304
modifier: MODEL1310110063#
name: D-Serine/Glycine reversible exchange
reversible: true
reactant: MODEL1310110063#
type: Reaction
kinetic law: MODEL1310110063#
notes: GENE_ASSOCIATION: (56301.1) and (6520.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10734121,PMID:10863037,PMID:14770310 NOTES:
fast: false

metaM dttp e
constant: false
initial amount: NaN
notes: FORMULA: C10H13N2O14P3 CHARGE: -4 INCHI: InChI=1S/C10H17N2O14P3/c1-5-3-12(10(15)11-9(5)14)8-2-6(13)7(24-8)4-23-28(19,20)26-29(21,22)25-27(16,17)18/h3,6-8,13H,2,4H2,1H3,(H,19,20)(H,21,22)(H,11,14,15)(H2,16,17,18)/p-4/t6-,7+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00368 EHMN_ABBREVIATION: C00459
name: dTTP(4-)
type: Species
has only substance units: false
is: SBO:0000247
initial concentration: 1.0
boundary condition: false
is: HMDB01342
is: CHEBI:37568

http://identifiers.org/biomodels.db/MODEL1310110063#_3f2d549e_3ae0_4266_adc8_8c12ce98841f
is encoded by: hsa:6487
has only substance units: false
name: ST3GAL3
boundary condition: true
type: Species
is: SBO:0000252
constant: false
initial amount: NaN
initial concentration: NaN

metaR FALDH
reactant: MODEL1310110063#
kinetic law: MODEL1310110063#
fast: false
modifier: MODEL1310110063#
reversible: true
is version of: http://identifiers.org/ec-code/1.1.1.1
name: formaldehyde dehydrogenase
notes: GENE_ASSOCIATION: (128.1) SUBSYSTEM: Tyrosine metabolism EC Number: 1.2.1.1 Confidence Level: 4 AUTHORS: PMID:4436331,PMID:8460164 NOTES:NCD
is described by: ECO:0000269
is: SBO:0000176
product: MODEL1310110063#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110063#_5fe42aa9_6073_4a72_8b5e_2d96dcec037f
boundary condition: true
constant: false
initial amount: NaN
is: SBO:0000252
is encoded by: hsa:AI345944
has only substance units: false
initial concentration: NaN
type: Species
name: _AI345944_1_m

http://identifiers.org/biomodels.db/MODEL1310110063#_11e2277f_822a_439a_9e78_b3dcf7c598a0
initial amount: NaN
type: Species
name: _LOC647190_1_c
initial concentration: NaN
is: SBO:0000252
constant: false
boundary condition: true
is encoded by: hsa:LOC647190
has only substance units: false

metaR EX dgchol LPAREN e RPAREN
kinetic law: MODEL1310110063#
reactant: MODEL1310110063#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Chenodeoxyglycocholate exchange
type: Reaction

metaM xol27oh m
initial amount: NaN
type: Species
notes: FORMULA: C27H46O2 CHARGE: 0 INCHI: InChI=1S/C27H46O2/c1-18(17-28)6-5-7-19(2)23-10-11-24-22-9-8-20-16-21(29)12-14-26(20,3)25(22)13-15-27(23,24)4/h8,18-19,21-25,28-29H,5-7,9-17H2,1-4H3/t18?,19-,21+,22+,23-,24+,25+,26+,27-/m1/s1 EHMN_ABBREVIATION: C06340
initial concentration: 1.0
boundary condition: false
is: CHEBI:17703
is: SBO:0000247
name: 26-hydroxycholesterol
constant: false
is: HMDB02103
has only substance units: false

metaM xoltetrol c
is: SBO:0000247
is: CHEBI:17278
initial concentration: 1.0
notes: FORMULA: C27H48O4 CHARGE: 0 INCHI: InChI=1S/C27H48O4/c1-16(15-28)6-5-7-17(2)20-8-9-21-25-22(14-24(31)27(20,21)4)26(3)11-10-19(29)12-18(26)13-23(25)30/h16-25,28-31H,5-15H2,1-4H3/t16?,17-,18+,19-,20-,21+,22+,23-,24+,25+,26+,27-/m1/s1 EHMN_ABBREVIATION: C05446
type: Species
boundary condition: false
has only substance units: false
is: HMDB01231
constant: false
initial amount: NaN
name: 5beta-cholestane-3alpha,7alpha,12alpha,26-tetrol

metaR r0145
kinetic law: MODEL1310110063#
product: MODEL1310110063#
reversible: true
is: SBO:0000176
fast: false
name: L-Arginine,NADPH:oxygen oxidoreductase (nitric-oxide-forming) Arginine and proline metabolism EC:1.14.13.39
modifier: MODEL1310110063#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (6821.1) SUBSYSTEM: Arginine and Proline Metabolism EC Number: 1.14.13.39 Confidence Level: 0 AUTHORS: PMID:11125020,PMID:7515853 NOTES:
is version of: http://identifiers.org/ec-code/1.8.3.1
reactant: MODEL1310110063#
type: Reaction

metaM lnlncg c
name: gamma-linolenate
is: SBO:0000247
is: CHEBI:32391
initial amount: NaN
initial concentration: 1.0
notes: FORMULA: C18H29O2 CHARGE: -1 INCHI: InChI=1S/C18H30O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20/h6-7,9-10,12-13H,2-5,8,11,14-17H2,1H3,(H,19,20)/p-1/b7-6-,10-9-,13-12-
constant: false
boundary condition: false
is: HMDB03073
has only substance units: false
type: Species

metaR NMNATr
reversible: true
product: MODEL1310110063#
fast: false
type: Reaction
is version of: http://identifiers.org/ec-code/2.7.7.1
kinetic law: MODEL1310110063#
reactant: MODEL1310110063#
name: nicotinamide-nucleotide adenylyltransferase
is described by: ECO:0000269
modifier: MODEL1310110063#
notes: GENE_ASSOCIATION: (349565.1) or (23057.1) or (23057.2) SUBSYSTEM: NAD metabolism EC Number: Confidence Level: 4 AUTHORS: NOTES:
is: SBO:0000176

metaR C226CRNt
reactant: MODEL1310110063#
type: Reaction
is described by: ECO:0000000
name: C226 transport into the mitochondria
reversible: false
product: MODEL1310110063#
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: PMID:14598172 NOTES:TDV
kinetic law: MODEL1310110063#
fast: false
is: SBO:0000185

metaM cmp g
is: HMDB00095
name: CMP(2-)
is: CHEBI:60377
constant: false
type: Species
notes: FORMULA: C9H12N3O8P CHARGE: -2 INCHI: InChI=1S/C9H14N3O8P/c10-5-1-2-12(9(15)11-5)8-7(14)6(13)4(20-8)3-19-21(16,17)18/h1-2,4,6-8,13-14H,3H2,(H2,10,11,15)(H2,16,17,18)/p-2/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00060 EHMN_ABBREVIATION: C00055
has only substance units: false
is: SBO:0000247
boundary condition: false
initial amount: NaN
initial concentration: 1.0

metaR CYSSERNaEx
is: SBO:0000185
product: MODEL1310110063#
reactant: MODEL1310110063#
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (6509.1) or (6510.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14530974 NOTES:SAB see Kanai and Hediger 2004 (2003), PMID 14530974
fast: false
kinetic law: MODEL1310110063#
reversible: false
modifier: MODEL1310110063#
type: Reaction
name: L-serine/L-cysteine Na-dependent exchange (Cys-L in)

metaR FADtx
reactant: MODEL1310110063#
fast: false
product: MODEL1310110063#
reversible: true
name: FAD transporter, peroxisomal
is: SBO:0000185
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 1 AUTHORS: NOTES:most likely NOT physiological - detailed information about the peroxisomal transporters has not yet been achieved - this transport is most likely dependent on a concomitant energy consuming reaction (human ABC peroxisomal transporters: PEX family - check in future for new research articles describing biochemistry and stoichiometry) NJ
type: Reaction
kinetic law: MODEL1310110063#

metaM ppa e
type: Species
is: CHEBI:17272
name: propionate
boundary condition: false
notes: FORMULA: C3H5O2 CHARGE: -1 INCHI: InChI=1S/C3H6O2/c1-2-3(4)5/h2H2,1H3,(H,4,5)/p-1 HEPATONET_1.0_ABBREVIATION: HC00158 EHMN_ABBREVIATION: C00163
initial concentration: 1.0
initial amount: NaN
has only substance units: false
is: HMDB00237
is: SBO:0000247
constant: false

metaR TMNDNCt
reactant: MODEL1310110063#
is: SBO:0000185
fast: false
name: fatty acid transport via diffusion
type: Reaction
kinetic law: MODEL1310110063#
product: MODEL1310110063#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11788354,PMID:12864740 NOTES:NJ
reversible: true
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110063#_805b5943_41b3_43a7_9aee_b03718a20235
constant: false
is: SBO:0000252
type: Species
is: P16066
initial amount: NaN
initial concentration: NaN
has only substance units: false
name: NPR1
boundary condition: true
is encoded by: hsa:4881

metaM duri c
initial amount: NaN
type: Species
is: C00526
name: Deoxyuridine
is: HMDB00012
boundary condition: false
initial concentration: 1.0
constant: false
has only substance units: false
notes: FORMULA: C9H12N2O5 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00410 EHMN_ABBREVIATION: C00526
is: SBO:0000247
is: CHEBI:16450

metaM cs e deg3 l
notes: FORMULA: C37H53NO44S4 CHARGE: -6
is: CHEBI:15748
name: chondroitin sulfate E (GalNAc4,6diS-GlcA), degradation product 3
is: HMDB00127
type: Species
initial concentration: 1.0
initial amount: NaN
boundary condition: false
has only substance units: false
is: SBO:0000247
constant: false

metaM 56dthm m
type: Species
initial amount: NaN
constant: false
initial concentration: 1.0
is: HMDB00079
name: 5,6-dihydrothymine
boundary condition: false
has only substance units: false
is: CHEBI:27468
notes: FORMULA: C5H8N2O2 CHARGE: 0 INCHI: InChI=1S/C5H8N2O2/c1-3-2-6-5(9)7-4(3)8/h3H,2H2,1H3,(H2,6,7,8,9) HEPATONET_1.0_ABBREVIATION: HC00582 EHMN_ABBREVIATION: C00906
is: SBO:0000247

metaR 5OXPROt
kinetic law: MODEL1310110063#
name: Transport of 5-oxoprolinate
type: Reaction
reversible: true
is: SBO:0000185
fast: false
is described by: ECO:0000134
product: MODEL1310110063#
reactant: MODEL1310110063#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:

metaM dad 2 c
is: HMDB00101
is: SBO:0000247
initial concentration: 1.0
constant: false
initial amount: NaN
has only substance units: false
is: CHEBI:17256
notes: FORMULA: C10H13N5O3 CHARGE: 0 INCHI: InChI=1S/C10H13N5O3/c11-9-8-10(13-3-12-9)15(4-14-8)7-1-5(17)6(2-16)18-7/h3-7,16-17H,1-2H2,(H2,11,12,13)/t5-,6+,7+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00431
boundary condition: false
name: 2-deoxyadenosine
type: Species

metaR GDPtg
reversible: true
name: GDP intracellular transport
product: MODEL1310110063#
kinetic law: MODEL1310110063#
reactant: MODEL1310110063#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 1 AUTHORS: NOTES:unknown mechanism for transport - likely translocated, unknown transporter/mechanism though NJ
is described by: ECO:0000000
fast: false
type: Reaction

metaR GALASE8ly
type: Reaction
reversible: false
fast: false
kinetic law: MODEL1310110063#
is described by: ECO:0000000
modifier: MODEL1310110063#
is: SBO:0000176
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) or (5476.1) and (2720.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.23 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD
is version of: http://identifiers.org/ec-code/3.2.1.23
is version of: http://identifiers.org/ec-code/3.2.1.18
product: MODEL1310110063#
name: beta-galactosidase, lysosomal
reactant: MODEL1310110063#
is version of: http://identifiers.org/ec-code/3.4.16.5
is version of: http://identifiers.org/ec-code/3.1.6.4

http://identifiers.org/biomodels.db/MODEL1310110063#_c1b04157_3628_4b63_947c_1219beab3cdf
name: PRODH
initial amount: NaN
initial concentration: NaN
is: SBO:0000252
is: O43272
has only substance units: false
constant: false
boundary condition: true
is encoded by: hsa:5625
type: Species

metaR S6TASE8ly
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/3.4.16.5
is version of: http://identifiers.org/ec-code/3.1.6.4
product: MODEL1310110063#
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) SUBSYSTEM: Chondroitin sulfate degradation EC Number: 3.1.6.4 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD
kinetic law: MODEL1310110063#
modifier: MODEL1310110063#
name: N-acetylgalactosamine-6-sulfatase, lysosomal
reversible: true
is: SBO:0000176
fast: false
reactant: MODEL1310110063#
type: Reaction
is version of: http://identifiers.org/ec-code/3.2.1.23
is version of: http://identifiers.org/ec-code/3.2.1.18

http://identifiers.org/biomodels.db/MODEL1310110063#_481b9af4_a657_4639_927d_d2d8c6b577cd
is: Q02218
initial concentration: NaN
boundary condition: true
is: SBO:0000252
type: Species
has only substance units: false
is encoded by: hsa:4967
constant: false
name: OGDH
initial amount: NaN

metaM 34dhpac c
has only substance units: false
notes: FORMULA: C8H8O3 CHARGE: 0 INCHI: InChI=1S/C8H8O3/c9-4-3-6-1-2-7(10)8(11)5-6/h1-2,4-5,10-11H,3H2 EHMN_ABBREVIATION: C04043
is: CHEBI:27978
name: 3,4-Dihydroxyphenylacetaldehyde
constant: false
initial amount: NaN
initial concentration: 1.0
boundary condition: false
is: SBO:0000247
type: Species
is: HMDB03791

metaM dgmp e
notes: FORMULA: C10H12N5O7P CHARGE: -2 INCHI: InChI=1S/C10H14N5O7P/c11-10-13-8-7(9(17)14-10)12-3-15(8)6-1-4(16)5(22-6)2-21-23(18,19)20/h3-6,16H,1-2H2,(H2,18,19,20)(H3,11,13,14,17)/p-2/t4-,5+,6+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00306 EHMN_ABBREVIATION: C00362
is: HMDB01044
constant: false
type: Species
initial concentration: 1.0
boundary condition: false
initial amount: NaN
name: dGMP(2-)
is: CHEBI:57673
has only substance units: false
is: SBO:0000247

metaM h2o g
has only substance units: false
notes: FORMULA: H2O CHARGE: 0 INCHI: InChI=1S/H2O/h1H2 HEPATONET_1.0_ABBREVIATION: HC00011 EHMN_ABBREVIATION: C00001
is: SBO:0000247
is: CHEBI:15377
name: water
initial amount: NaN
initial concentration: 1.0
type: Species
boundary condition: false
constant: false
is: HMDB02111

metaM gsn c
name: Guanosine
notes: FORMULA: C10H13N5O5 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00322 EHMN_ABBREVIATION: C00387
initial concentration: 1.0
boundary condition: false
type: Species
constant: false
is: HMDB00133
initial amount: NaN
is: SBO:0000247
has only substance units: false
is: C00387
is: CHEBI:16750

metaM dmnoncoa m
notes: FORMULA: C32H54N7O17P3S CHARGE: -4 INCHI: InChI=1/C32H56N7O17P3S/c1-19(2)7-6-8-20(3)9-10-23(41)60-14-13-34-22(40)11-12-35-30(44)27(43)32(4,5)16-53-59(50,51)56-58(48,49)52-15-21-26(55-57(45,46)47)25(42)31(54-21)39-18-38-24-28(33)36-17-37-29(24)39/h17-21,25-27,31,42-43H,6-16H2,1-5H3,(H,34,40)(H,35,44)(H,48,49)(H,50,51)(H2,33,36,37)(H2,45,46,47)/t20?,21-,25-,26-,27?,31-/m1/s1
initial concentration: 1.0
name: 4,8 dimethylnonanoyl-CoA
constant: false
boundary condition: false
type: Species
initial amount: NaN
is: SBO:0000247
is: HMDB11604
has only substance units: false

metaM hs deg8 l
type: Species
initial amount: NaN
has only substance units: false
name: heparan sulfate, degradation product 8
constant: false
initial concentration: 1.0
is: SBO:0000247
boundary condition: false
notes: FORMULA: C69H100N4O81S8 CHARGE: -10
is: CHEBI:16126

metaR EX hdcea LPAREN e RPAREN
kinetic law: MODEL1310110063#
reactant: MODEL1310110063#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for Hexadecenoate (n-C16:1)
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110063#_0f8912fc_342b_4b42_8096_610f1b21275e
initial concentration: NaN
has only substance units: false
is: SBO:0000252
is: P53004
type: Species
constant: false
boundary condition: true
is encoded by: hsa:644
name: BLVRA
initial amount: NaN

metaR FACOAL1812
product: MODEL1310110063#
name: fatty-acid--CoA ligase
notes: GENE_ASSOCIATION: (2180.1) SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 4 AUTHORS: PMID:15292367 NOTES:NJ
type: Reaction
modifier: MODEL1310110063#
reactant: MODEL1310110063#
fast: false
reversible: true
is version of: http://identifiers.org/ec-code/6.2.1.3
is described by: ECO:0000000
is: SBO:0000176
kinetic law: MODEL1310110063#

metaR FATP8t
name: fatty acid electroneutral transport
reactant: MODEL1310110063#
product: MODEL1310110063#
modifier: MODEL1310110063#
is: SBO:0000185
type: Reaction
is described by: ECO:0000269
fast: false
reversible: true
notes: GENE_ASSOCIATION: (10998.1) or (11001.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10479480,PMID:12856180,PMID:15522816 NOTES:electroneutral transport NJ
is version of: http://identifiers.org/ec-code/6.2.1.3
is version of: http://identifiers.org/ec-code/6.2.1.7
kinetic law: MODEL1310110063#

http://identifiers.org/biomodels.db/MODEL1310110063#_4bf01454_d2ad_4f8c_a74e_4509b77f7db2
initial amount: NaN
constant: false
has only substance units: false
type: Species
boundary condition: true
is encoded by: hsa:10587
initial concentration: NaN
name: TXNRD2
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110063#_6adfb341_9d65_4c1c_9332_a46a43713072
is encoded by: hsa:124637
initial amount: NaN
has only substance units: false
name: CYB5D1
constant: false
is: Q6P9G0
type: Species
boundary condition: true
is: SBO:0000252
initial concentration: NaN

metaM cdp c
is: HMDB01546
boundary condition: false
has only substance units: false
initial amount: NaN
name: CDP
is: CHEBI:58069
notes: FORMULA: C9H12N3O11P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00110 EHMN_ABBREVIATION: C00112
is: SBO:0000247
is: C00112
type: Species
initial concentration: 1.0
constant: false

metaR H2O2tp
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: PMID:2989289 NOTES:NCD
reversible: true
kinetic law: MODEL1310110063#
is described by: ECO:0000000
fast: false
product: MODEL1310110063#
is: SBO:0000185
reactant: MODEL1310110063#
type: Reaction
name: hydrogen peroxide peroxisomal transport via diffusion

http://identifiers.org/biomodels.db/MODEL1310110063#_4fb6087d_adff_467e_9cda_2f1af641fc21
is: SBO:0000252
initial concentration: NaN
is encoded by: hsa:5052
constant: false
has only substance units: false
initial amount: NaN
name: PRDX1
type: Species
boundary condition: true

metaR EX leuktrA4 LPAREN e RPAREN
kinetic law: MODEL1310110063#
reactant: MODEL1310110063#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: leukotriene A4 exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110063#_a53ce905_f3c9_48bd_865b_fe1334b6fc4c
is: P04181
is encoded by: hsa:4942
initial amount: NaN
is: SBO:0000252
name: OAT
has only substance units: false
initial concentration: NaN
constant: false
type: Species
boundary condition: true

metaM 5adtststerone c
name: 17beta-hydroxy-5alpha-androstan-3-one
type: Species
is: HMDB02961
notes: FORMULA: C19H30O2 CHARGE: 0 INCHI: InChI=1S/C19H30O2/c1-18-9-7-13(20)11-12(18)3-4-14-15-5-6-17(21)19(15,2)10-8-16(14)18/h12,14-17,21H,3-11H2,1-2H3/t12-,14-,15-,16-,17-,18-,19-/m0/s1 EHMN_ABBREVIATION: C03917
has only substance units: false
is: CHEBI:16330
initial concentration: 1.0
constant: false
boundary condition: false
is: SBO:0000247
initial amount: NaN

metaR ACGPID
kinetic law: MODEL1310110063#
fast: false
modifier: MODEL1310110063#
reactant: MODEL1310110063#
product: MODEL1310110063#
type: Reaction
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (9487.1) SUBSYSTEM: Phosphatidylinositol phosphate metabolism EC Number: 3.5.1.89 Confidence Level: 4 AUTHORS: PMID:10085243,PMID:14742432 NOTES:NCD
reversible: false
name: N-acetylglucosaminylphosphatidylinositol deacetylase
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.5.1.89

metaM 3docopencoa x
has only substance units: false
constant: false
type: Species
notes: FORMULA: C43H64N7O17P3S CHARGE: -4
name: 3,7,10,13,16-docosapentenoylcoa
is: http://identifiers.org/pubchem.compound/24892790
boundary condition: false
initial concentration: 1.0
is: SBO:0000247
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110063#_7809ba4a_d856_447f_876e_5571eb412df1
constant: false
is: Q8WXF9
boundary condition: true
type: Species
has only substance units: false
is: SBO:0000252
name: SLC2A11
is encoded by: hsa:66035
initial concentration: NaN
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110063#_444b018a_be70_4e77_872a_cc1fe0b9dc14
type: Species
constant: false
is encoded by: hsa:5287
boundary condition: true
is: SBO:0000252
initial concentration: NaN
has only substance units: false
name: PIK3C2B
initial amount: NaN
is: O00750

metaM dudp c
initial amount: NaN
is: C01346
type: Species
name: dUDP
initial concentration: 1.0
notes: FORMULA: C9H11N2O11P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00768 EHMN_ABBREVIATION: C01346
boundary condition: false
is: HMDB01000
is: CHEBI:60471
constant: false
is: SBO:0000247
has only substance units: false

metaM dad 2 e
notes: FORMULA: C10H13N5O3 CHARGE: 0 INCHI: InChI=1S/C10H13N5O3/c11-9-8-10(13-3-12-9)15(4-14-8)7-1-5(17)6(2-16)18-7/h3-7,16-17H,1-2H2,(H2,11,12,13)/t5-,6+,7+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00431
is: SBO:0000247
constant: false
boundary condition: false
initial concentration: 1.0
is: HMDB00101
type: Species
is: CHEBI:17256
initial amount: NaN
name: 2-deoxyadenosine
has only substance units: false

metaM lnlncg l
has only substance units: false
name: gamma-linolenate
boundary condition: false
initial amount: NaN
initial concentration: 1.0
notes: FORMULA: C18H29O2 CHARGE: -1 INCHI: InChI=1S/C18H30O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20/h6-7,9-10,12-13H,2-5,8,11,14-17H2,1H3,(H,19,20)/p-1/b7-6-,10-9-,13-12- HEPATONET_1.0_ABBREVIATION: HC01757 EHMN_ABBREVIATION: C06426
type: Species
constant: false
is: HMDB03073
is: SBO:0000247
is: CHEBI:32391

metaR TYRTAm
is version of: http://identifiers.org/ec-code/2.6.1.1
name: tyrosine transaminase, mitochondrial
modifier: MODEL1310110063#
reversible: true
notes: GENE_ASSOCIATION: (6898.1) or (2806.1) SUBSYSTEM: Tyrosine metabolism EC Number: 2.6.1.5 Confidence Level: 4 AUTHORS: PMID:1973834 NOTES:NCD
fast: false
type: Reaction
kinetic law: MODEL1310110063#
product: MODEL1310110063#
is: SBO:0000176
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/2.6.1.5
reactant: MODEL1310110063#

http://identifiers.org/biomodels.db/MODEL1310110063#_9cebe645_b30b_46f5_8722_53f57c8fae82
constant: false
type: Species
initial amount: NaN
name: PDE6D
is encoded by: hsa:5147
is: O43924
boundary condition: true
is: SBO:0000252
has only substance units: false
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110063#_15357ba8_7eee_4800_8567_2aa883520d9b
is: SBO:0000252
initial amount: NaN
type: Species
has only substance units: false
initial concentration: NaN
name: _AI285872_1_c
is encoded by: hsa:AI285872
constant: false
boundary condition: true

metaR G14T18g
product: MODEL1310110063#
type: Reaction
is: SBO:0000176
name: beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase, Golgi
fast: false
modifier: MODEL1310110063#
is version of: http://identifiers.org/ec-code/2.4.1.90
is version of: http://identifiers.org/ec-code/2.4.1.22
reversible: false
notes: GENE_ASSOCIATION: (8703.1) or (8704.2) or (8704.1) or (2683.1) or (9334.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.38 Confidence Level: 4 AUTHORS: PMID:10747980,PMID:12512857,PMID:1903938,PMID:3094506,PMID:3144273,PMID:9405390,PMID:9435216 NOTES:Keratan sulfate II biosynthesis NCD
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/2.4.1.38
kinetic law: MODEL1310110063#
reactant: MODEL1310110063#

metaM glutcoa m
constant: false
is: HMDB01339
initial amount: NaN
notes: FORMULA: C26H37N7O19P3S CHARGE: -5 INCHI: InChI=1S/C26H42N7O19P3S/c1-26(2,21(39)24(40)29-7-6-15(34)28-8-9-56-17(37)5-3-4-16(35)36)11-49-55(46,47)52-54(44,45)48-10-14-20(51-53(41,42)43)19(38)25(50-14)33-13-32-18-22(27)30-12-31-23(18)33/h12-14,19-21,25,38-39H,3-11H2,1-2H3,(H,28,34)(H,29,40)(H,35,36)(H,44,45)(H,46,47)(H2,27,30,31)(H2,41,42,43)/p-5/t14-,19-,20-,21+,25-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00411 EHMN_ABBREVIATION: C00527
has only substance units: false
name: glutaryl-CoA(5-)
type: Species
is: SBO:0000247
initial concentration: 1.0
is: CHEBI:57378
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110063#_c055f85f_a9af_4895_a4af_89e3f7175f9b
is: SBO:0000252
name: _AI971023_1_c
is encoded by: hsa:AI971023
type: Species
constant: false
initial amount: NaN
boundary condition: true
has only substance units: false
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110063#_da3a543c_29e4_4ed8_83e9_1e8bc0d61af1
type: Species
initial amount: NaN
has only substance units: false
initial concentration: NaN
is encoded by: hsa:218
name: ALDH3A1
is: SBO:0000252
is: P30838
boundary condition: true
constant: false

metaR r0860
notes: GENE_ASSOCIATION: (8879.1) SUBSYSTEM: Purine catabolism EC Number: Confidence Level: 0 AUTHORS: PMID:1459,PMID:14598172,PMID:18406340,PMID:8132483 NOTES:
fast: false
reactant: MODEL1310110063#
modifier: MODEL1310110063#
kinetic law: MODEL1310110063#
type: Reaction
name: Utilized transport
reversible: true
is described by: ECO:0000000
product: MODEL1310110063#
is version of: http://identifiers.org/ec-code/4.1.2.27
is: SBO:0000185

metaR EX prostgi2 LPAREN e RPAREN
kinetic law: MODEL1310110063#
reactant: MODEL1310110063#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: prostaglandin I2(1-) exchange
type: Reaction

metaM dgmp c
has only substance units: false
is: C00362
notes: FORMULA: C10H12N5O7P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00306 EHMN_ABBREVIATION: C00362
name: dGMP
initial amount: NaN
is: CHEBI:57673
is: HMDB01044
is: SBO:0000247
type: Species
initial concentration: 1.0
boundary condition: false
constant: false

http://identifiers.org/biomodels.db/MODEL1310110063#_8eb8b182_9a11_434f_a972_b680d746d035
is: SBO:0000252
type: Species
constant: false
name: ALPI
initial amount: NaN
is: P09923
is encoded by: hsa:248
boundary condition: true
initial concentration: NaN
has only substance units: false

metaR r0149
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.14.13.39
name: CTP diphosphohydrolase Pyrimidine metabolism EC:3.6.1.5
is described by: ECO:0000000
modifier: MODEL1310110063#
fast: false
product: MODEL1310110063#
kinetic law: MODEL1310110063#
notes: GENE_ASSOCIATION: (285973.1) or (D29675.1) or (4842.1) or (NOS2A.1) or (4846.1) SUBSYSTEM: Pyrimidine catabolism EC Number: 3.6.1.5 Confidence Level: 0 AUTHORS: PMID:15652174,PMID:16752921,PMID:17095758 NOTES:
reactant: MODEL1310110063#
reversible: true
type: Reaction

metaM ppi n
notes: FORMULA: HO7P2 CHARGE: -3 INCHI: InChI=1S/H4O7P2/c1-8(2,3)7-9(4,5)6/h(H2,1,2,3)(H2,4,5,6)/p-3 HEPATONET_1.0_ABBREVIATION: HC00023 EHMN_ABBREVIATION: C00013
initial concentration: 1.0
is: CHEBI:33019
is: SBO:0000247
type: Species
initial amount: NaN
boundary condition: false
name: diphosphate(3-)
constant: false
has only substance units: false
is: HMDB00250

metaM cdp e
initial amount: NaN
boundary condition: false
has only substance units: false
is: CHEBI:58069
name: CDP(3-)
is: SBO:0000247
notes: FORMULA: C9H12N3O11P2 CHARGE: -3 INCHI: InChI=1S/C9H15N3O11P2/c10-5-1-2-12(9(15)11-5)8-7(14)6(13)4(22-8)3-21-25(19,20)23-24(16,17)18/h1-2,4,6-8,13-14H,3H2,(H,19,20)(H2,10,11,15)(H2,16,17,18)/p-3/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00110 EHMN_ABBREVIATION: C00112
type: Species
constant: false
is: HMDB01546
initial concentration: 1.0

metaM ipdp c
notes: FORMULA: C5H9O7P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00127 EHMN_ABBREVIATION: C00129
is: SBO:0000247
is: C00129
is: HMDB01347
type: Species
boundary condition: false
initial concentration: 1.0
constant: false
name: Isopentenyl diphosphate
is: CHEBI:128769
initial amount: NaN
has only substance units: false

metaM ksii core2 pre8 g
name: keratan sulfate II biosynthesis, precursor 8
notes: FORMULA: C75H121N6O56SX CHARGE: -2
is: C00130
type: Species
is: SBO:0000247
boundary condition: false
is: HMDB00175
initial amount: NaN
has only substance units: false
is: CHEBI:58053
constant: false
initial concentration: 1.0

metaM gly e
initial concentration: 1.0
constant: false
type: Species
is: HMDB00123
notes: FORMULA: C2H5NO2 CHARGE: 0
name: Glycine
boundary condition: false
is: SBO:0000247
has only substance units: false
is: CHEBI:3339
is: C00037
initial amount: NaN

metaR DCATDc
kinetic law: MODEL1310110063#
product: MODEL1310110063#
reactant: MODEL1310110063#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: transport of Decanoate (n-C10:0) into the cell by diffusion
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110063#_b80b3502_d603_4651_adaf_44754bedb448
boundary condition: true
is: P42336
constant: false
is encoded by: hsa:5290
name: PIK3CA
initial amount: NaN
type: Species
is: SBO:0000252
initial concentration: NaN
has only substance units: false

metaR DNDPt27m
notes: GENE_ASSOCIATION: (60386.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:11226231 NOTES:IT
reactant: MODEL1310110063#
type: Reaction
modifier: MODEL1310110063#
reversible: false
fast: false
product: MODEL1310110063#
name: dCDP transport via dTDP antiport
is: SBO:0000185
is described by: ECO:0000269
kinetic law: MODEL1310110063#

metaR H2O2tn
reactant: MODEL1310110063#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: PMID:2989289 NOTES:it
type: Reaction
is: SBO:0000185
fast: false
product: MODEL1310110063#
reversible: true
is described by: ECO:0000000
name: hydrogen peroxide nuclear transport
kinetic law: MODEL1310110063#

metaM ile L c
notes: FORMULA: C6H13NO2 CHARGE: 0 INCHI: InChI=1S/C6H13NO2/c1-3-4(2)5(7)6(8)9/h4-5H,3,7H2,1-2H3,(H,8,9)/t4-,5-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00334 EHMN_ABBREVIATION: C00407
initial amount: NaN
is: HMDB00172
type: Species
is: SBO:0000247
constant: false
boundary condition: false
initial concentration: 1.0
is: CHEBI:17191
name: L-isoleucine
has only substance units: false

metaM decdp m
is: HMDB06288
type: Species
notes: FORMULA: C50H81O7P2 CHARGE: -3 INCHI: InChI=1/C50H90O7P2/c1-41(2)21-31-53-58(51,54-32-22-42(3)4)57-59(52,35-25-45(9)10,36-26-46(11)12,37-27-47(13)14,38-28-48(15)16,39-29-49(17)18,40-30-50(19)20,55-33-23-43(5)6)56-34-24-44(7)8/h21-30H,31-40H2,1-20H3
initial amount: NaN
is: SBO:0000247
constant: false
name: all trans Decaprenyl diphosphate
boundary condition: false
has only substance units: false
initial concentration: 1.0

metaR THMP
notes: GENE_ASSOCIATION: SUBSYSTEM: Thiamine metabolism EC Number: Confidence Level: 1 AUTHORS: PMID:11997266,PMID:8522961 NOTES:EC 3.1.3.- NCD
fast: false
reactant: MODEL1310110063#
type: Reaction
is described by: ECO:0000000
product: MODEL1310110063#
reversible: false
is: SBO:0000176
name: thiamin phosphatase
kinetic law: MODEL1310110063#

http://identifiers.org/biomodels.db/MODEL1310110063#_8c03a4e3_18d7_443e_8fd3_3f3130ef1971
has only substance units: false
is encoded by: hsa:T83654
type: Species
constant: false
initial amount: NaN
name: _T83654_1_e
initial concentration: NaN
is: SBO:0000252
boundary condition: true

metaM malcoa c
notes: FORMULA: C24H33N7O19P3S CHARGE: -5 HEPATONET_1.0_ABBREVIATION: HC00086 EHMN_ABBREVIATION: C00083
name: Malonyl-CoA
is: SBO:0000247
initial amount: NaN
boundary condition: false
is: CHEBI:57384
has only substance units: false
initial concentration: 1.0
constant: false
is: C00083
type: Species
is: HMDB01175

metaM s2l2n2m2masn e
has only substance units: false
is: SBO:0000247
is: HMDB00244
boundary condition: false
initial concentration: 1.0
name: de-Fuc form of PA6
constant: false
type: Species
is: C00255
is: CHEBI:3554
initial amount: NaN
notes: FORMULA: C84H135N6O61X CHARGE: -2

http://identifiers.org/biomodels.db/MODEL1310110063#_a31235c5_df64_496d_9d4e_e5b7eb8ebd74
is encoded by: hsa:81031
is: O95528
initial amount: NaN
constant: false
is: SBO:0000252
has only substance units: false
initial concentration: NaN
type: Species
boundary condition: true
name: SLC2A10

metaM ppi m
boundary condition: false
is: CHEBI:33019
is: SBO:0000247
type: Species
name: Diphosphate
initial amount: NaN
is: C00013
constant: false
has only substance units: false
initial concentration: 1.0
notes: FORMULA: HO7P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00023 EHMN_ABBREVIATION: C00013
is: HMDB00250

http://identifiers.org/biomodels.db/MODEL1310110063#_3489cc00_ec3c_4097_b795_8f9a05a9730a
is: P54868
has only substance units: false
initial concentration: NaN
boundary condition: true
constant: false
type: Species
is encoded by: hsa:3158
name: HMGCS2
is: SBO:0000252
initial amount: NaN

metaR r1527
name: ATP-binding Cassette (ABC) TCDB:3.A.1.211.1
reversible: false
is described by: ECO:0000000
reactant: MODEL1310110063#
notes: GENE_ASSOCIATION: (AI024818.1) or (AI091231.1) or (AI480132.1) or (AI972237.1) or (AL050025.1) or (759.1) or (771.1) or (377677.1) or (23632.1) or (760.1) or (761.1) or (762.1) or (763.1) or (11238.1) or (765.1) or (766.1) or (767.1) or (768.1) or (8883.1) or (R51273.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:16858612 NOTES:
is version of: http://identifiers.org/ec-code/4.2.1.1
modifier: MODEL1310110063#
product: MODEL1310110063#
is: SBO:0000185
type: Reaction
kinetic law: MODEL1310110063#
fast: false

http://identifiers.org/biomodels.db/MODEL1310110063#_b5fcd367_a60b_4881_90f4_dd9538b92092
initial amount: NaN
is encoded by: hsa:50484
type: Species
has only substance units: false
name: RRM2B
is: Q7LG56
boundary condition: true
initial concentration: NaN
is: SBO:0000252
constant: false

metaM xol27oh r
constant: false
notes: FORMULA: C27H46O2 CHARGE: 0 INCHI: InChI=1S/C27H46O2/c1-18(17-28)6-5-7-19(2)23-10-11-24-22-9-8-20-16-21(29)12-14-26(20,3)25(22)13-15-27(23,24)4/h8,18-19,21-25,28-29H,5-7,9-17H2,1-4H3/t18?,19-,21+,22+,23-,24+,25+,26+,27-/m1/s1 EHMN_ABBREVIATION: C06340
boundary condition: false
name: 26-hydroxycholesterol
is: SBO:0000247
has only substance units: false
type: Species
is: CHEBI:17703
initial amount: NaN
initial concentration: 1.0
is: HMDB02103

metaR FACOAL1813
type: Reaction
modifier: MODEL1310110063#
product: MODEL1310110063#
kinetic law: MODEL1310110063#
name: fatty-acid--CoA ligase
reversible: true
notes: GENE_ASSOCIATION: (2180.1) SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 4 AUTHORS: PMID:15292367 NOTES:NJ
is version of: http://identifiers.org/ec-code/6.2.1.3
is: SBO:0000176
is described by: ECO:0000269
reactant: MODEL1310110063#
fast: false

metaR r2396
product: MODEL1310110063#
reactant: MODEL1310110063#
type: Reaction
is described by: ECO:0000000
name: Mitochondrial Carrier (MC) TCDB:2.A.29.19.1
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172 NOTES:
reversible: false
kinetic law: MODEL1310110063#
fast: false

metaM h2o c
boundary condition: false
initial concentration: 1.0
has only substance units: false
notes: FORMULA: H2O CHARGE: 0
type: Species
name: H2O
is: HMDB02111
initial amount: NaN
is: SBO:0000247
constant: false
is: C00001
is: CHEBI:3303

http://identifiers.org/biomodels.db/MODEL1310110063#_2cb9351a_b846_4ad4_bb68_0006afcd412e
is: P13804
initial amount: NaN
constant: false
type: Species
is: SBO:0000252
name: ETFA
boundary condition: true
initial concentration: NaN
is encoded by: hsa:2108
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110063#_84624fca_01df_450e_a186_b027b5171eea
has only substance units: false
name: HADHA
initial amount: NaN
is: SBO:0000252
is encoded by: hsa:3030
is: E9KL44
constant: false
initial concentration: NaN
boundary condition: true
type: Species

http://identifiers.org/biomodels.db/MODEL1310110063#_6be8af81_42a1_44ff_90f4_cb8bdfd0fad1
has only substance units: false
constant: false
boundary condition: true
initial concentration: NaN
name: _AI697028_1_m
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:AI697028
type: Species

metaR FAOXC2252053m
modifier: MODEL1310110063#
is version of: http://identifiers.org/ec-code/1.3.8.1
fast: false
product: MODEL1310110063#
is version of: http://identifiers.org/ec-code/1.3.99.3
notes: GENE_ASSOCIATION: (35.1) or (34.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.74 Confidence Level: 4 AUTHORS: NOTES:_1 round beta ox - c22:5,n-3 -> c20:5, n-3 - final '3' in abbreviation indicates omega3 FA 4 step FAO lumped for 2 rounds also includes EC 1.1.1.35, 1.1.1.211, 1.3.3.6, 4.2.1.17, 4.2.1.74 NJ
kinetic law: MODEL1310110063#
is: SBO:0000176
is described by: ECO:0000000
type: Reaction
reactant: MODEL1310110063#
reversible: false
name: Beta oxidation of long chain fatty acid

metaR r1942
is described by: ECO:0000000
modifier: MODEL1310110063#
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
product: MODEL1310110063#
kinetic law: MODEL1310110063#
reversible: false
type: Reaction
reactant: MODEL1310110063#
is: SBO:0000185
name: Y+LAT2 Utilized transport
fast: false

metaM gly c
initial amount: NaN
name: Glycine
constant: false
boundary condition: false
is: HMDB00123
notes: FORMULA: C2H5NO2 CHARGE: 0
type: Species
has only substance units: false
is: SBO:0000247
is: CHEBI:3339
initial concentration: 1.0
is: C00037

metaR EX nrpphr LPAREN e RPAREN
kinetic law: MODEL1310110063#
reactant: MODEL1310110063#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Norepinephrine exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110063#_5c6a0e52_b70d_4017_853f_c22f0cde5ab7
boundary condition: true
is: SBO:0000252
is encoded by: hsa:10935
constant: false
type: Species
name: PRDX3
is: E9PH29
initial amount: NaN
has only substance units: false
initial concentration: NaN

metaM 3sala c
type: Species
boundary condition: false
name: 3-Sulfino-L-alanine
initial concentration: 1.0
constant: false
is: C00606
is: SBO:0000247
has only substance units: false
is: CHEBI:61085
notes: FORMULA: C3H5NO4S CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00451 EHMN_ABBREVIATION: C00606
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110063#_fe9e14d6_c1ba_4870_a58a_4dcc710afbf2
is encoded by: hsa:55163
initial amount: NaN
boundary condition: true
has only substance units: false
type: Species
constant: false
initial concentration: NaN
is: Q9NVS9
is: SBO:0000252
name: PNPO

metaR OCTDECCACT
kinetic law: MODEL1310110063#
product: MODEL1310110063#
reactant: MODEL1310110063#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: transport of Octadecenoyl-CoA into mitochondrial matrix
type: Reaction

metaR r2397
type: Reaction
is described by: ECO:0000000
reversible: false
kinetic law: MODEL1310110063#
fast: false
name: Mitochondrial Carrier (MC) TCDB:2.A.29.19.1
product: MODEL1310110063#
reactant: MODEL1310110063#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172 NOTES:

metaM ile L e
is: HMDB00172
has only substance units: false
name: L-isoleucine
constant: false
is: SBO:0000247
is: CHEBI:17191
boundary condition: false
initial concentration: 1.0
initial amount: NaN
notes: FORMULA: C6H13NO2 CHARGE: 0 INCHI: InChI=1S/C6H13NO2/c1-3-4(2)5(7)6(8)9/h4-5H,3,7H2,1-2H3,(H,8,9)/t4-,5-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00334 EHMN_ABBREVIATION: C00407
type: Species

metaM xoltetrol m
is: SBO:0000247
type: Species
constant: false
boundary condition: false
initial amount: NaN
has only substance units: false
name: 5beta-cholestane-3alpha,7alpha,12alpha,26-tetrol
initial concentration: 1.0
is: CHEBI:17278
is: HMDB01231
notes: FORMULA: C27H48O4 CHARGE: 0 INCHI: InChI=1S/C27H48O4/c1-16(15-28)6-5-7-17(2)20-8-9-21-25-22(14-24(31)27(20,21)4)26(3)11-10-19(29)12-18(26)13-23(25)30/h16-25,28-31H,5-15H2,1-4H3/t16?,17-,18+,19-,20-,21+,22+,23-,24+,25+,26+,27-/m1/s1 EHMN_ABBREVIATION: C05446

metaM 3hmp m
notes: FORMULA: C4H7O3 CHARGE: -1 INCHI: InChI=1S/C4H8O3/c1-3(2-5)4(6)7/h3,5H,2H2,1H3,(H,6,7)/p-1 HEPATONET_1.0_ABBREVIATION: HC00705 EHMN_ABBREVIATION: C01188
is: HMDB00023
is: SBO:0000247
name: 3-hydroxy-2-methylpropanoate
initial amount: NaN
constant: false
has only substance units: false
initial concentration: 1.0
is: CHEBI:11805
boundary condition: false
type: Species

metaR C161OHc
kinetic law: MODEL1310110063#
product: MODEL1310110063#
reactant: MODEL1310110063#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: production of 3-hydroxyhexadecenoylcarnitine
type: Reaction

metaM HC02206 e
notes: FORMULA: C20H31O4 CHARGE: -1 INCHI: InChI=1S/C20H32O4/c1-2-3-6-9-17(21)14-12-16-13-15-19(22)18(16)10-7-4-5-8-11-20(23)24/h12-14,17-18,21H,2-11,15H2,1H3,(H,23,24)/p-1/b14-12+/t17-,18+/m0/s1 EHMN_ABBREVIATION: C04686
is: SBO:0000247
initial concentration: 1.0
is: CHEBI:57399
initial amount: NaN
constant: false
has only substance units: false
name: prostaglandin C1(1-)
boundary condition: false
type: Species

metaR HEXDCRNe
kinetic law: MODEL1310110063#
product: MODEL1310110063#
reactant: MODEL1310110063#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of 3-hydroxyhexadecanoyl carnitine into extra cellular space
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110063#_afed89aa_6ca9_4dae_b0a9_40646d51bb4f
constant: false
boundary condition: true
initial concentration: NaN
has only substance units: false
initial amount: NaN
is encoded by: hsa:8875
is encoded by: hsa:55350
name: VNN3:VNN2:VNN1
type: Species
is encoded by: hsa:8876
has part: A8K7W0
is: SBO:0000297
has part: O95497

metaR NDP7ex
reversible: false
is described by: ECO:0000269
is: SBO:0000176
reactant: MODEL1310110063#
type: Reaction
kinetic law: MODEL1310110063#
name: nucleoside-diphosphatase (UDP), extracellular
modifier: MODEL1310110063#
product: MODEL1310110063#
is version of: http://identifiers.org/ec-code/3.6.1.6
notes: GENE_ASSOCIATION: (124583.1) SUBSYSTEM: Nucleotide interconversion EC Number: 3.6.1.6 Confidence Level: 4 AUTHORS: PMID:12600208 NOTES:
fast: false

metaR GALU
type: Reaction
is version of: http://identifiers.org/ec-code/2.7.7.9
reversible: true
kinetic law: MODEL1310110063#
is: SBO:0000176
product: MODEL1310110063#
modifier: MODEL1310110063#
is described by: ECO:0000134
reactant: MODEL1310110063#
name: UTP-glucose-1-phosphate uridylyltransferase
fast: false
notes: GENE_ASSOCIATION: (7360.1) or (7359.1) or (7360.2) SUBSYSTEM: Galactose metabolism EC Number: 2.7.7.9 Confidence Level: 0 AUTHORS: PMID:9119383 NOTES:Human Y/N: Y

metaR SERTHRNaEx
reactant: MODEL1310110063#
product: MODEL1310110063#
fast: false
reversible: false
is described by: ECO:0000269
type: Reaction
notes: GENE_ASSOCIATION: (6509.1) or (6510.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14530974 NOTES:SAB see Kanai and Hediger 2004 (2003), PMID 14530974
modifier: MODEL1310110063#
kinetic law: MODEL1310110063#
name: L-serine/L-threonine Na-dependent exchange (Ser-L in)
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110063#_7a13d2fa_2963_45a4_a369_717c626b7b5f
type: Species
initial amount: NaN
initial concentration: NaN
boundary condition: true
is: Q5SPY7
is: SBO:0000252
name: ENTPD2
constant: false
is encoded by: hsa:954
has only substance units: false

metaM phyt x
is: SBO:0000247
has only substance units: false
is: CHEBI:37257
boundary condition: false
notes: FORMULA: C20H39O2 CHARGE: -1 INCHI: InChI=1S/C20H40O2/c1-16(2)9-6-10-17(3)11-7-12-18(4)13-8-14-19(5)15-20(21)22/h16-19H,6-15H2,1-5H3,(H,21,22)/p-1 EHMN_ABBREVIATION: C01607
constant: false
initial amount: NaN
initial concentration: 1.0
name: phytanate
type: Species
is: HMDB00801

metaR G14Tg
modifier: MODEL1310110063#
reactant: MODEL1310110063#
is version of: http://identifiers.org/ec-code/2.4.1.38
product: MODEL1310110063#
is: SBO:0000176
name: beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase
kinetic law: MODEL1310110063#
reversible: false
is described by: ECO:0000269
type: Reaction
is version of: http://identifiers.org/ec-code/2.4.1.90
is version of: http://identifiers.org/ec-code/2.4.1.22
notes: GENE_ASSOCIATION: (9334.1) or (2683.1) or (8704.1) or (8703.1) or (8704.2) SUBSYSTEM: N-glycan synthesis EC Number: 2.4.1.38 Confidence Level: 4 AUTHORS: PMID:9597550 NOTES:NCD
fast: false

http://identifiers.org/biomodels.db/MODEL1310110063#_c72ad05b_d18d_4c56_8ac5_f1c4d823ab39
has only substance units: false
is: SBO:0000252
constant: false
name: PIP5K1B
is encoded by: hsa:8395
initial amount: NaN
boundary condition: true
is: O14986
initial concentration: NaN
type: Species

metaM CE5854 e
initial amount: NaN
constant: false
name: gama-CEHC-glucuronide
boundary condition: false
has only substance units: false
is: SBO:0000247
type: Species
notes: FORMULA: C21H27O10 CHARGE: -1 INCHI: InChI=1/C21H28O10/c1-9-10(2)17-11(8-12(9)22)4-6-21(3,31-17)7-5-13(23)29-20-16(26)14(24)15(25)18(30-20)19(27)28/h8,14-16,18,20,22,24-26H,4-7H2,1-3H3,(H,27,28)/p-1/t14-,15+,16-,18-,20+,21?/m1/s1 EHMN_ABBREVIATION: CE5854
initial concentration: 1.0
is: CHEBI:27485
is: HMDB02710

metaM h2o e
constant: false
initial concentration: 1.0
is: CHEBI:15377
notes: FORMULA: H2O CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00011 EHMN_ABBREVIATION: C00001
is: C00001
initial amount: NaN
boundary condition: false
name: H2O
type: Species
has only substance units: false
is: HMDB02111
is: SBO:0000247

metaM biocyt c
has only substance units: false
is: SBO:0000247
is: C05552
initial concentration: 1.0
notes: FORMULA: C16H28N4O4S CHARGE: 0 INCHI: InChI=1/C16H28N4O4S/c17-10(15(22)23)5-3-4-8-18-13(21)7-2-1-6-12-14-11(9-25-12)19-16(24)20-14/h10-12,14H,1-9,17H2,(H,18,21)(H,22,23)(H2,19,20,24)/t10-,11-,12-,14-/m0/s1 EHMN_ABBREVIATION: C05552
name: Biocytin
boundary condition: false
type: Species
is: http://identifiers.org/pubchem.compound/7886
constant: false
is: HMDB03134
initial amount: NaN

metaR RE2660N
name: RE2660
is: SBO:0000176
product: MODEL1310110063#
modifier: MODEL1310110063#
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/4.2.1.96
reactant: MODEL1310110063#
notes: GENE_ASSOCIATION: (5092.1) or (84105.1) SUBSYSTEM: Tetrahydrobiopterin metabolism EC Number: 4.2.1.96 Confidence Level: 0 AUTHORS: PMID:8921004 NOTES:
reversible: true
type: Reaction
kinetic law: MODEL1310110063#
fast: false

http://identifiers.org/biomodels.db/MODEL1310110063#_7b74c60b_fbd3_4e07_8edb_22917f0a970b
constant: false
is: O00767
is: SBO:0000252
is encoded by: hsa:6319
name: SCD
boundary condition: true
initial amount: NaN
has only substance units: false
type: Species
initial concentration: NaN

metaM glc D r
name: D-glucose
is: SBO:0000247
initial concentration: 1.0
is: CHEBI:4167
type: Species
is: HMDB00122
notes: FORMULA: C6H12O6 CHARGE: 0 INCHI: InChI=1S/C6H12O6/c7-1-2-3(8)4(9)5(10)6(11)12-2/h2-11H,1H2/t2-,3-,4+,5-,6?/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00040
initial amount: NaN
has only substance units: false
boundary condition: false
constant: false

metaM ppa m
is: SBO:0000247
name: propionate
initial concentration: 1.0
initial amount: NaN
has only substance units: false
is: HMDB00237
notes: FORMULA: C3H5O2 CHARGE: -1 INCHI: InChI=1S/C3H6O2/c1-2-3(4)5/h2H2,1H3,(H,4,5)/p-1 HEPATONET_1.0_ABBREVIATION: HC00158 EHMN_ABBREVIATION: C00163
is: CHEBI:17272
type: Species
boundary condition: false
constant: false

metaR CORE3GTg
fast: false
is version of: http://identifiers.org/ec-code/2.4.1.149
notes: GENE_ASSOCIATION: (192134.1) SUBSYSTEM: O-glycan synthesis EC Number: 2.4.1.147 Confidence Level: 0 AUTHORS: PMID:11821425 NOTES:NCD
is described by: ECO:0000000
product: MODEL1310110063#
type: Reaction
is: SBO:0000176
modifier: MODEL1310110063#
name: Core 3 beta-GlcNAc-transferase, Golgi apparatus
kinetic law: MODEL1310110063#
reversible: false
reactant: MODEL1310110063#

http://identifiers.org/biomodels.db/MODEL1310110063#_238356df_2fe7_46a3_986c_052119a70c5a
initial concentration: NaN
constant: false
has only substance units: false
name: INPP5E
boundary condition: true
initial amount: NaN
type: Species
is: SBO:0000252
is: Q9NRR6
is encoded by: hsa:56623

metaR r1940
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
product: MODEL1310110063#
kinetic law: MODEL1310110063#
reversible: false
is described by: ECO:0000000
name: Y+LAT2 Utilized transport
type: Reaction
reactant: MODEL1310110063#
fast: false
is: SBO:0000185
modifier: MODEL1310110063#

metaM ppi r
initial amount: NaN
name: Diphosphate
is: C00013
boundary condition: false
type: Species
has only substance units: false
initial concentration: 1.0
notes: FORMULA: HO7P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00023 EHMN_ABBREVIATION: C00013
is: SBO:0000247
constant: false
is: HMDB00250
is: CHEBI:33019

http://identifiers.org/biomodels.db/MODEL1310110063#_eb9a75ad_029c_475e_92bd_bcb514b4a5f7
boundary condition: true
is: P11168
constant: false
initial concentration: NaN
name: SLC2A2
initial amount: NaN
is encoded by: hsa:6514
has only substance units: false
is: SBO:0000252
type: Species

metaR SUCOASm
is version of: http://identifiers.org/ec-code/6.2.1.5
is described by: ECO:0000000
name: Succinate--CoA ligase (ADP-forming)
product: MODEL1310110063#
reactant: MODEL1310110063#
fast: false
modifier: MODEL1310110063#
is version of: http://identifiers.org/ec-code/6.2.1.4
type: Reaction
is: SBO:0000176
notes: GENE_ASSOCIATION: (8802.1 and 8803.1) SUBSYSTEM: Citric acid cycle EC Number: 6.2.1.5 Confidence Level: 0 AUTHORS: PMID:9765291 NOTES:MIPS: cofactor ATP IF changed EC from 6.2.1.4 to 6.2.1.5 - NCD
reversible: true
kinetic law: MODEL1310110063#

http://identifiers.org/biomodels.db/MODEL1310110063#_f9ba85fd_bbe5_4cac_8a5c_331e5cac1562
boundary condition: true
has only substance units: false
initial concentration: NaN
initial amount: NaN
name: NOS3
type: Species
constant: false
is encoded by: hsa:4846
is: A0S0A7
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110063#_45d48ce9_4553_4ab9_bbcd_1c7f63d92a74
is encoded by: hsa:2687
name: GGT5
initial concentration: NaN
boundary condition: true
type: Species
has only substance units: false
initial amount: NaN
is: P36269
constant: false
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110063#_90a29e07_892b_4515_ae9c_78651c6fa04c
is: SBO:0000252
is encoded by: hsa:115286
type: Species
name: SLC25A26
is: Q70HW3
constant: false
initial amount: NaN
boundary condition: true
has only substance units: false
initial concentration: NaN

metaM tetpent6coa x
boundary condition: false
name: tetracosapentaenoyl coenzyme A, n-6
constant: false
is: C16172
initial concentration: 1.0
type: Species
is: SBO:0000247
initial amount: NaN
notes: FORMULA: C45H68N7O17P3S CHARGE: -4 INCHI: InChI=1/C45H72N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-24-25-36(54)73-29-28-47-35(53)26-27-48-43(57)40(56)45(2,3)31-66-72(63,64)69-71(61,62)65-30-34-39(68-70(58,59)60)38(55)44(67-34)52-33-51-37-41(46)49-32-50-42(37)52/h8-9,11-12,14-15,17-18,20-21,32-34,38-40,44,55-56H,4-7,10,13,16,19,22-31H2,1-3H3,(H,47,53)(H,48,57)(H,61,62)(H,63,64)(H2,46,49,50)(H2,58,59,60)/b9-8-,12-11-,15-14-,18-17-,21-20-/t34-,38-,39-,40?,44-/m1/s1
has only substance units: false

metaR EX 3mob LPAREN e RPAREN
kinetic law: MODEL1310110063#
reactant: MODEL1310110063#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: Exchange of 3-methyl-2-oxobutanoate
type: Reaction

metaM ddsmsterol r
initial concentration: 1.0
constant: false
has only substance units: false
is: SBO:0000247
type: Species
notes: FORMULA: C27H42O CHARGE: 0 INCHI: InChI=1S/C27H42O/c1-18(2)7-6-8-19(3)23-11-12-24-22-10-9-20-17-21(28)13-15-26(20,4)25(22)14-16-27(23,24)5/h7,9-10,19,21,23-25,28H,6,8,11-17H2,1-5H3/t19-,21+,23-,24+,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01373
is: CHEBI:27910
boundary condition: false
is: HMDB03896
name: 7-dehydrodesmosterol
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110063#_4e398759_810d_44bd_8fe7_7ce799ec8f3b
name: NAGA
constant: false
initial concentration: NaN
is: P17050
is: SBO:0000252
initial amount: NaN
boundary condition: true
is encoded by: hsa:4668
type: Species
has only substance units: false

metaR ADEt
reactant: MODEL1310110063#
notes: GENE_ASSOCIATION: (3177.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12006583,PMID:12838422 NOTES:NCD
reversible: true
product: MODEL1310110063#
name: adenine reversible transport, cytosol
fast: false
is: SBO:0000185
is described by: ECO:0000269
kinetic law: MODEL1310110063#
type: Reaction
modifier: MODEL1310110063#

http://identifiers.org/biomodels.db/MODEL1310110063#_d5122b1b_7492_4659_b095_99bf03593022
initial concentration: NaN
name: _AA081045_1_e
is: SBO:0000252
is encoded by: hsa:AA081045
constant: false
has only substance units: false
boundary condition: true
type: Species
initial amount: NaN

metaR FAOXC201C181x
kinetic law: MODEL1310110063#
product: MODEL1310110063#
reactant: MODEL1310110063#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta xoidation(C20:1-->C18:1)x
type: Reaction

metaR 3MOBt2im
reactant: MODEL1310110063#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:8428987 NOTES:MM
is described by: ECO:0000000
product: MODEL1310110063#
type: Reaction
is: SBO:0000185
reversible: false
name: 3-methyl-2-oxobutanoate mitochondrial transport via proton symport
kinetic law: MODEL1310110063#

http://identifiers.org/biomodels.db/MODEL1310110063#_d82fc1ea_3630_48a1_b5ca_f0e692946e33
initial amount: NaN
has only substance units: false
boundary condition: true
initial concentration: NaN
is: SBO:0000252
constant: false
name: OXSM
is encoded by: hsa:54995
is: Q9NWU1
type: Species

metaM btcoa c
constant: false
is: SBO:0000247
initial amount: NaN
is: C00136
has only substance units: false
initial concentration: 1.0
name: Butanoyl-CoA
notes: FORMULA: C25H38N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00134 EHMN_ABBREVIATION: C00136
is: HMDB01088
type: Species
is: CHEBI:57371
boundary condition: false

metaR RE3218C
notes: GENE_ASSOCIATION: (412.1) SUBSYSTEM: Androgen and estrogen synthesis and metabolism EC Number: 3.1.6.2 Confidence Level: 0 AUTHORS: PMID:11886493 NOTES:IT - fixed proton
name: RE3218
reversible: true
is: SBO:0000176
kinetic law: MODEL1310110063#
is described by: ECO:0000000
modifier: MODEL1310110063#
reactant: MODEL1310110063#
product: MODEL1310110063#
is version of: http://identifiers.org/ec-code/3.1.6.2
fast: false
type: Reaction

metaR AKGtp
reversible: true
fast: false
reactant: MODEL1310110063#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 0 AUTHORS: NOTES:unknown mechanism NJ
type: Reaction
is: SBO:0000185
product: MODEL1310110063#
is described by: ECO:0000000
kinetic law: MODEL1310110063#
name: AKG transporter, peroxisome

metaM 44mctr r
notes: FORMULA: C29H46O CHARGE: 0 INCHI: InChI=1S/C29H46O/c1-19(2)9-8-10-20(3)22-12-13-23-21-11-14-25-27(4,5)26(30)16-18-29(25,7)24(21)15-17-28(22,23)6/h9,13,20,22,25-26,30H,8,10-12,14-18H2,1-7H3/t20-,22-,25+,26+,28-,29-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01808 EHMN_ABBREVIATION: C11455
type: Species
name: 4,4-dimethyl-5alpha-cholesta-8,14,24-trien-3beta-ol
is: CHEBI:17813
initial amount: NaN
constant: false
has only substance units: false
is: SBO:0000247
is: HMDB01023
boundary condition: false
initial concentration: 1.0

metaM dump c
type: Species
is: SBO:0000247
initial concentration: 1.0
is: HMDB01409
constant: false
initial amount: NaN
has only substance units: false
notes: FORMULA: C9H11N2O8P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00309 EHMN_ABBREVIATION: C00365
name: dUMP
is: CHEBI:246422
is: C00365
boundary condition: false

metaM ksi pre9 g
type: Species
is: C00130
is: HMDB00175
initial amount: NaN
notes: FORMULA: C121H196N8O93S2X CHARGE: -3
is: CHEBI:58053
has only substance units: false
name: keratan sulfate I biosynthesis, precursor 9
initial concentration: 1.0
constant: false
boundary condition: false
is: SBO:0000247

metaM 5adtststerone e
name: 17beta-hydroxy-5alpha-androstan-3-one
is: HMDB02961
notes: FORMULA: C19H30O2 CHARGE: 0 INCHI: InChI=1S/C19H30O2/c1-18-9-7-13(20)11-12(18)3-4-14-15-5-6-17(21)19(15,2)10-8-16(14)18/h12,14-17,21H,3-11H2,1-2H3/t12-,14-,15-,16-,17-,18-,19-/m0/s1 EHMN_ABBREVIATION: C03917
is: CHEBI:16330
constant: false
has only substance units: false
type: Species
is: SBO:0000247
initial amount: NaN
initial concentration: 1.0
boundary condition: false

metaR r2314
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
reversible: true
product: MODEL1310110063#
is described by: ECO:0000000
fast: false
is: SBO:0000185
kinetic law: MODEL1310110063#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
type: Reaction
reactant: MODEL1310110063#

metaM chlstol r
is: SBO:0000247
has only substance units: false
initial amount: NaN
notes: FORMULA: C27H44O CHARGE: 0 INCHI: InChI=1S/C27H44O/c1-18(2)7-6-8-19(3)23-11-12-24-22-10-9-20-17-21(28)13-15-26(20,4)25(22)14-16-27(23,24)5/h7,10,19-21,23-25,28H,6,8-9,11-17H2,1-5H3/t19-,20+,21+,23-,24+,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01452 EHMN_ABBREVIATION: C05439
type: Species
name: 5alpha-cholesta-7,24-dien-3beta-ol
initial concentration: 1.0
constant: false
is: HMDB06842
boundary condition: false
is: CHEBI:16290

metaM 1pyr5c m
boundary condition: false
is: CHEBI:15893
is: C03912
initial amount: NaN
name: 1-Pyrroline-5-carboxylate
notes: FORMULA: C5H6NO2 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC01199 EHMN_ABBREVIATION: C03912
type: Species
is: HMDB01301
is: SBO:0000247
has only substance units: false
constant: false
initial concentration: 1.0

metaM dhcholestancoa r
has only substance units: false
initial amount: NaN
is: CHEBI:15494
boundary condition: false
notes: FORMULA: C48H76N7O19P3S CHARGE: -4 INCHI: InChI=1S/C48H80N7O19P3S/c1-26(30-10-11-31-36-32(13-16-48(30,31)6)47(5)15-12-29(56)20-28(47)21-33(36)57)8-7-9-27(2)45(62)78-19-18-50-35(58)14-17-51-43(61)40(60)46(3,4)23-71-77(68,69)74-76(66,67)70-22-34-39(73-75(63,64)65)38(59)44(72-34)55-25-54-37-41(49)52-24-53-42(37)55/h24-34,36,38-40,44,56-57,59-60H,7-23H2,1-6H3,(H,50,58)(H,51,61)(H,66,67)(H,68,69)(H2,49,52,53)(H2,63,64,65)/t26-,27?,28+,29-,30-,31+,32+,33-,34-,36+,38-,39-,40+,44-,47+,48-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01332 EHMN_ABBREVIATION: C04644
is: SBO:0000247
constant: false
name: 3alpha,7alpha-Dihydroxy-5beta-cholestanoyl-CoA
is: HMDB02159
type: Species
initial concentration: 1.0

metaM pnto R c
initial concentration: 1.0
initial amount: NaN
notes: FORMULA: C9H16NO5 CHARGE: -1 INCHI: InChI=1S/C9H17NO5/c1-9(2,5-11)7(14)8(15)10-4-3-6(12)13/h7,11,14H,3-5H2,1-2H3,(H,10,15)(H,12,13) HEPATONET_1.0_ABBREVIATION: HC00568
constant: false
has only substance units: false
is: SBO:0000247
name: (R)-Pantothenate
type: Species
boundary condition: false
is: HMDB00210
is: CHEBI:7916

metaR 34DHPLACOX NADP
name: 3,4-Dihydroxyphenylacetaldehyde:NADP+ oxidoreductase
is: SBO:0000176
reactant: MODEL1310110063#
type: Reaction
fast: false
is version of: http://identifiers.org/ec-code/1.2.1.5
kinetic law: MODEL1310110063#
is described by: ECO:0000269
product: MODEL1310110063#
modifier: MODEL1310110063#
notes: GENE_ASSOCIATION: (222.1) or (221.1) or (218.1) SUBSYSTEM: Tyrosine metabolism EC Number: 1.2.1.5 Confidence Level: 4 AUTHORS: PMID:11306106,PMID:2071588 NOTES:SAB
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110063#_58493825_b22f_40e3_8a60_75457ae6e8a3
initial amount: NaN
is: P39656
boundary condition: true
initial concentration: NaN
has only substance units: false
name: DDOST
constant: false
is: SBO:0000252
type: Species
is encoded by: hsa:1650

metaR 4HBZCOAFm
product: MODEL1310110063#
kinetic law: MODEL1310110063#
reactant: MODEL1310110063#
notes: GENE_ASSOCIATION: SUBSYSTEM: Ubiquinone synthesis EC Number: Confidence Level: 2 AUTHORS: PMID:11583838,PMID:12232327 NOTES:IT reaction involved in formation of 4-hydroxybenzoate from tyrosine.
name: 4-hydroxybenzoyl-CoA formation
reversible: false
is: SBO:0000176
fast: false
type: Reaction
is described by: ECO:0000000

metaR AG13T9g
kinetic law: MODEL1310110063#
reactant: MODEL1310110063#
reversible: false
notes: GENE_ASSOCIATION: (146712.1) or (79369.1) or (10331.1) or (374907.1) or (10678.2) or (374907.2) or (10678.1) or (11041.1) or (93010.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.149 Confidence Level: 4 AUTHORS: PMID:10747980,PMID:11042166,PMID:12061784,PMID:12512857,PMID:15560372,PMID:15620693,PMID:9405606 NOTES:NCD
name: N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase, Golgi apparatus
is: SBO:0000176
product: MODEL1310110063#
is version of: http://identifiers.org/ec-code/2.4.1.149
modifier: MODEL1310110063#
is described by: ECO:0000000
fast: false
type: Reaction

metaM HC02203 c
type: Species
constant: false
name: prostaglandin-a2
has only substance units: false
initial concentration: 1.0
notes: FORMULA: C20H29O4 CHARGE: -1 INCHI: InChI=1S/C20H30O4/c1-2-3-6-9-17(21)14-12-16-13-15-19(22)18(16)10-7-4-5-8-11-20(23)24/h4,7,12-18,21H,2-3,5-6,8-11H2,1H3,(H,23,24)/b7-4-,14-12+/t16-,17-,18+/m0/s1 EHMN_ABBREVIATION: C05953
is: CHEBI:27820
initial amount: NaN
boundary condition: false
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110063#_af62f71f_551a_4cf7_bf59_54e093548142
has only substance units: false
name: ESCO2
is: SBO:0000252
is: Q56NI9
constant: false
initial amount: NaN
is encoded by: hsa:157570
type: Species
initial concentration: NaN
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110063#_8fbbf781_8270_415b_b77a_fb13ca47ee10
has only substance units: false
constant: false
boundary condition: true
type: Species
is: SBO:0000252
name: ENPP3
initial concentration: NaN
is encoded by: hsa:5169
is: Q308M7
initial amount: NaN

metaM 3hexdcoa c
is: HMDB03932
has only substance units: false
notes: FORMULA: C37H62N7O18P3S CHARGE: -4
initial amount: NaN
constant: false
boundary condition: false
name: 3-hydroxyhexadecanoylcoa
type: Species
is: SBO:0000247
is: C05258
initial concentration: 1.0

metaR XOL27OHtm
product: MODEL1310110063#
is described by: ECO:0000000
type: Reaction
reactant: MODEL1310110063#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 1 AUTHORS: NOTES:unknown mechanism NJ
kinetic law: MODEL1310110063#
fast: false
name: 27 hydroxy cholesterol transport
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110063#_7734d230_4fe7_42d6_8436_ac6bb145c86e
has only substance units: false
is: SBO:0000252
name: SLC27A1
is: Q6PCB7
initial amount: NaN
is encoded by: hsa:376497
type: Species
boundary condition: true
constant: false
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110063#_9893c33d_4d1b_4b4b_87f0_22ea155bb294
initial concentration: NaN
constant: false
name: NDUFS7
has only substance units: false
is encoded by: hsa:374291
is: SBO:0000252
initial amount: NaN
is: O75251
type: Species
boundary condition: true

metaM 3snpyr m
boundary condition: false
constant: false
is: CHEBI:1665
notes: FORMULA: C3H2O5S CHARGE: -2 INCHI: InChI=1S/C3H4O5S/c4-2(3(5)6)1-9(7)8/h1H2,(H,5,6)(H,7,8) EHMN_ABBREVIATION: C05527
name: 3-Sulfinopyruvate
initial amount: NaN
type: Species
is: SBO:0000247
is: HMDB02332
initial concentration: 1.0
has only substance units: false

metaM spmd e
boundary condition: false
constant: false
type: Species
name: Spermidine
has only substance units: false
is: CHEBI:57834
is: HMDB01257
notes: FORMULA: C7H22N3 CHARGE: 3 HEPATONET_1.0_ABBREVIATION: HC00269 EHMN_ABBREVIATION: C00315
is: SBO:0000247
is: C00315
initial amount: NaN
initial concentration: 1.0

metaR G14T7g
product: MODEL1310110063#
notes: GENE_ASSOCIATION: (8704.1) or (8703.1) or (2683.1) or (9334.1) or (8704.2) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.38 Confidence Level: 4 AUTHORS: PMID:12512857,PMID:1903938,PMID:3094506,PMID:3144273,PMID:9405390,PMID:9435216 NOTES:Keratan sulfate I biosynthesis NCD
name: beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase, Golgi
reactant: MODEL1310110063#
fast: false
is version of: http://identifiers.org/ec-code/2.4.1.90
reversible: false
is version of: http://identifiers.org/ec-code/2.4.1.22
modifier: MODEL1310110063#
kinetic law: MODEL1310110063#
is version of: http://identifiers.org/ec-code/2.4.1.38
is described by: ECO:0000000
type: Reaction
is: SBO:0000176

metaR r2315
is described by: ECO:0000000
reactant: MODEL1310110063#
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
type: Reaction
product: MODEL1310110063#
fast: false
is: SBO:0000185
kinetic law: MODEL1310110063#
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110063#_9a0ea725_8c4c_40c5_9808_ffbf4d27693e
has only substance units: false
is encoded by: hsa:6392
type: Species
initial amount: NaN
is: SBO:0000252
initial concentration: NaN
is: O14521
name: SDHD
constant: false
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110063#_66503acf_40c8_4e2b_b4b4_835e3cc7307c
is: Q75T13
name: PGAP1
constant: false
initial amount: NaN
type: Species
is encoded by: hsa:80055
is: SBO:0000252
has only substance units: false
boundary condition: true
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110063#_492dc500_9fa6_497b_b0d7_4c6d4be7fcd9
initial amount: NaN
has only substance units: false
is encoded by: hsa:80308
name: FLAD1
type: Species
is: SBO:0000252
initial concentration: NaN
constant: false
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110063#_b331b32c_e226_41ad_9349_b3a9b86c2195
is: P00374
name: DHFR
constant: false
has only substance units: false
initial amount: NaN
is encoded by: hsa:1719
type: Species
boundary condition: true
initial concentration: NaN
is: SBO:0000252

metaR TMDK1
kinetic law: MODEL1310110063#
reactant: MODEL1310110063#
is version of: http://identifiers.org/ec-code/2.7.1.21
product: MODEL1310110063#
fast: false
is described by: ECO:0000269
name: thymidine kinase (ATP:thymidine)
modifier: MODEL1310110063#
reversible: false
is: SBO:0000176
notes: GENE_ASSOCIATION: (7084.1) or (7083.1) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: NOTES:
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110063#_00a26d94_06cc_425d_ad67_a67319b78b90
is: SBO:0000297
name: GALNS:GLB1:NEU1:CTSA
has part: P10619
boundary condition: true
is encoded by: hsa:2720
initial concentration: NaN
has part: Q99519
constant: false
is encoded by: hsa:5476
type: Species
initial amount: NaN
has part: P16278
has only substance units: false
is encoded by: hsa:4758
has part: P34059
is encoded by: hsa:2588

metaM orn e
notes: FORMULA: C5H13N2O2 CHARGE: 1
is: C01602
boundary condition: false
has only substance units: false
constant: false
initial concentration: 1.0
is: HMDB00214
is: SBO:0000247
initial amount: NaN
is: CHEBI:0
type: Species
name: Ornithine

http://identifiers.org/biomodels.db/MODEL1310110063#_484b8f09_d968_44ae_b7d9_e5ddcf11480b
initial amount: NaN
is encoded by: hsa:5092
has only substance units: false
boundary condition: true
is: SBO:0000252
type: Species
constant: false
initial concentration: NaN
is: P61457
name: PCBD1

metaR r2316
reversible: true
is described by: ECO:0000000
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
product: MODEL1310110063#
is: SBO:0000185
fast: false
type: Reaction
kinetic law: MODEL1310110063#
reactant: MODEL1310110063#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:

metaR EX 4hpro LPAREN e RPAREN
kinetic law: MODEL1310110063#
reactant: MODEL1310110063#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for hydroxy proline
type: Reaction

metaR EX 6dhf LPAREN e RPAREN
kinetic law: MODEL1310110063#
reactant: MODEL1310110063#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: haxglutamyl folate (DHF) exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110063#_8ee04e59_0921_45f6_9ea2_41decb4dd1d7
is: SBO:0000252
has only substance units: false
constant: false
initial concentration: NaN
initial amount: NaN
is: Q7L266
is encoded by: hsa:80150
type: Species
boundary condition: true
name: ASRGL1

http://identifiers.org/biomodels.db/MODEL1310110063#_0b9e2743_b430_4e77_83bf_9ff7f5dec48e
constant: false
name: ENTPD3
is: SBO:0000252
initial amount: NaN
has only substance units: false
boundary condition: true
is: O75355
initial concentration: NaN
type: Species
is encoded by: hsa:956

http://identifiers.org/biomodels.db/MODEL1310110063#_aaa8988f_861e_421b_9bfd_b46e147e7214
type: Species
name: B3GNT2
is encoded by: hsa:10678
boundary condition: true
constant: false
initial amount: NaN
has only substance units: false
initial concentration: NaN
is: SBO:0000252

metaR ORNt3m
notes: GENE_ASSOCIATION: (83884.1) or (10166.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172 NOTES:NCD
kinetic law: MODEL1310110063#
reactant: MODEL1310110063#
name: ornithine mitochondrial transport via proton antiport
modifier: MODEL1310110063#
product: MODEL1310110063#
fast: false
is described by: ECO:0000269
reversible: true
is: SBO:0000185
type: Reaction

metaM HC02216 c
name: prostaglandin-f2beta
has only substance units: false
constant: false
is: CHEBI:28922
initial amount: NaN
type: Species
notes: FORMULA: C20H33O5 CHARGE: -1 INCHI: InChI=1S/C20H34O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h4,7,12-13,15-19,21-23H,2-3,5-6,8-11,14H2,1H3,(H,24,25)/b7-4-,13-12+/t15-,16+,17+,18+,19+/m0/s1
boundary condition: false
initial concentration: 1.0
is: SBO:0000247

metaR GLCNACASE5ly
reversible: false
type: Reaction
reactant: MODEL1310110063#
is: SBO:0000176
kinetic law: MODEL1310110063#
is version of: http://identifiers.org/ec-code/3.2.1.50
product: MODEL1310110063#
fast: false
modifier: MODEL1310110063#
notes: GENE_ASSOCIATION: (4669.1) SUBSYSTEM: Heparan sulfate degradation EC Number: 3.2.1.50 Confidence Level: 4 AUTHORS: PMID:1783617,PMID:8776591,PMID:8993162 NOTES:NCD
name: alpha-N-acetylglucosaminidase, lysosomal
is described by: ECO:0000000

metaR 4ABUTtm
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: PMID:10407778 NOTES:NCD
reactant: MODEL1310110063#
type: Reaction
product: MODEL1310110063#
kinetic law: MODEL1310110063#
is described by: ECO:0000000
reversible: true
fast: false
name: 4-aminobutanoate mitochondrial transport via diffusion
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110063#_b7616116_49fb_432b_a4a3_240e16a38d0e
constant: false
is: SBO:0000252
boundary condition: true
is: Q5JPH6
type: Species
has only substance units: false
initial amount: NaN
is encoded by: hsa:124454
name: EARS2
initial concentration: NaN

metaM dmpp x
name: prenyl diphosphate(3-)
notes: FORMULA: C5H9O7P2 CHARGE: -3 INCHI: InChI=1S/C5H12O7P2/c1-5(2)3-4-11-14(9,10)12-13(6,7)8/h3H,4H2,1-2H3,(H,9,10)(H2,6,7,8)/p-3 HEPATONET_1.0_ABBREVIATION: HC00213 EHMN_ABBREVIATION: C00235
constant: false
initial concentration: 1.0
initial amount: NaN
type: Species
is: HMDB01120
is: SBO:0000247
is: CHEBI:57623
boundary condition: false
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110063#_8fd7d2dc_7a2f_4cf2_867b_55034e525228
is: SBO:0000252
type: Species
boundary condition: true
has only substance units: false
is encoded by: hsa:5232
constant: false
initial amount: NaN
initial concentration: NaN
is: P07205
name: PGK2

http://identifiers.org/biomodels.db/MODEL1310110063#_83e0839b_0935_4529_86ec_1ca8b702450d
is: B2RB13
type: Species
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:23305
constant: false
has only substance units: false
boundary condition: true
name: ACSL6
initial concentration: NaN

metaR GTHRDt
notes: GENE_ASSOCIATION: SUBSYSTEM: Glutathione metabolism EC Number: Confidence Level: 2 AUTHORS: NOTES:TV (8-15-2003) Meister, A, Mitochondrial changes associated with glutathione deficiency, Biochimica et Biophysica Acta 1271 (1995) 35-42. The article reports that this is an active transport but doesn't not specify if it uses atp.
product: MODEL1310110063#
fast: false
reversible: true
is described by: ECO:0000000
reactant: MODEL1310110063#
is: SBO:0000185
name: Glutathione transport into mitochondria
type: Reaction
kinetic law: MODEL1310110063#

metaR SQLEr
fast: false
notes: GENE_ASSOCIATION: (6713.1) SUBSYSTEM: Cholesterol metabolism EC Number: 1.14.99.7 Confidence Level: 4 AUTHORS: PMID:1964954 NOTES:NCD
is described by: ECO:0000134
is: SBO:0000176
kinetic law: MODEL1310110063#
reversible: false
name: Squalene epoxidase, endoplasmic reticular (NADP)
is version of: http://identifiers.org/ec-code/1.14.13.132
product: MODEL1310110063#
modifier: MODEL1310110063#
type: Reaction
reactant: MODEL1310110063#

metaR RPEc
kinetic law: MODEL1310110063#
type: Reaction
is described by: ECO:0000134
product: MODEL1310110063#
name: ribulose 5-phosphate 3-epimerase
notes: GENE_ASSOCIATION: SUBSYSTEM: Pentose phosphate pathway EC Number: 5.1.3.1 Confidence Level: 4 AUTHORS: PMID: 4382012, PMID: 13575411, Harpers illustrated Biochemistry (2009) 28th edition pages 174-183 NOTES:coefficient changed to 2
reactant: MODEL1310110063#
is: SBO:0000176
reversible: true
fast: false

metaR EX 4abut LPAREN e RPAREN
kinetic law: MODEL1310110063#
reactant: MODEL1310110063#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 4-Aminobutanoate exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110063#_39710222_cd8a_4129_adea_c2c2cc4ee338
name: HSD3B2
is: SBO:0000252
initial amount: NaN
type: Species
is encoded by: hsa:3284
is: P26439
has only substance units: false
constant: false
initial concentration: NaN
boundary condition: true

metaM spmd c
name: Spermidine
boundary condition: false
has only substance units: false
type: Species
constant: false
is: CHEBI:57834
notes: FORMULA: C7H22N3 CHARGE: 3 HEPATONET_1.0_ABBREVIATION: HC00269 EHMN_ABBREVIATION: C00315
is: HMDB01257
initial concentration: 1.0
is: SBO:0000247
is: C00315
initial amount: NaN

metaR r2317
reactant: MODEL1310110063#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
type: Reaction
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
product: MODEL1310110063#
is: SBO:0000185
fast: false
reversible: true
is described by: ECO:0000000
kinetic law: MODEL1310110063#

metaM clpndcoa x
initial amount: NaN
notes: FORMULA: C43H64N7O17P3S CHARGE: -4 INCHI: InChI=1/C43H68N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-34(52)71-27-26-45-33(51)24-25-46-41(55)38(54)43(2,3)29-64-70(61,62)67-69(59,60)63-28-32-37(66-68(56,57)58)36(53)42(65-32)50-31-49-35-39(44)47-30-48-40(35)50/h5-6,8-9,11-12,14-15,17-18,30-32,36-38,42,53-54H,4,7,10,13,16,19-29H2,1-3H3,(H,45,51)(H,46,55)(H,59,60)(H,61,62)(H2,44,47,48)(H2,56,57,58)/p-4/b6-5-,9-8-,12-11-,15-14-,18-17-/t32-,36+,37+,38?,42-/m0/s1
is: http://identifiers.org/pubchem.compound/47205476
constant: false
initial concentration: 1.0
name: clupanodonyl CoA
type: Species
is: C16166
is: SBO:0000247
is: HMDB06267
has only substance units: false
boundary condition: false

metaR FAOXC102C103x
kinetic law: MODEL1310110063#
product: MODEL1310110063#
reactant: MODEL1310110063#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C10:2-->C10:3)x
type: Reaction

metaR DM Ser Gly Ala X Gly ly
kinetic law: MODEL1310110063#
reactant: MODEL1310110063#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 0 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: false
name: DM Ser-Gly/Ala-X-Gly(ly)
type: Reaction

metaM dcdp n
has only substance units: false
notes: FORMULA: C9H12N3O10P2 CHARGE: -3 INCHI: InChI=1S/C9H15N3O10P2/c10-7-1-2-12(9(14)11-7)8-3-5(13)6(21-8)4-20-24(18,19)22-23(15,16)17/h1-2,5-6,8,13H,3-4H2,(H,18,19)(H2,10,11,14)(H2,15,16,17)/p-3/t5-,6+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00506 EHMN_ABBREVIATION: C00705
is: HMDB01245
constant: false
is: SBO:0000247
initial amount: NaN
initial concentration: 1.0
name: dCDP(3-)
type: Species
is: CHEBI:58593
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110063#_8d102ab5_3457_4d16_b279_205e10ab537d
initial concentration: NaN
has only substance units: false
type: Species
initial amount: NaN
has part: P23921
is encoded by: hsa:6241
constant: false
name: RRM1:RRM2
boundary condition: true
has part: P31350
is encoded by: hsa:6240
is: SBO:0000297

metaR FAOXC226205m
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.3.99.3
type: Reaction
is described by: ECO:0000000
modifier: MODEL1310110063#
reactant: MODEL1310110063#
fast: false
name: Beta oxidation of long chain fatty acid
notes: GENE_ASSOCIATION: (35.1) or (34.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.74 Confidence Level: 4 AUTHORS: PMID:2565344,PMID:3035565 NOTES:_1 round of beta-oxidation, loses degree of desat, so no fad peroxisomal (very long chain FA) c22:6,n-3 -> c20:5, n-3 4 step FAO lumped also includes EC 1.1.1.35, 1.1.1.211, 1.3.3.6, 4.2.1.17, 4.2.1.74 NJ
kinetic law: MODEL1310110063#
product: MODEL1310110063#
reversible: false
is version of: http://identifiers.org/ec-code/1.3.8.1

metaM cysam c
is: CHEBI:58029
is: HMDB02991
has only substance units: false
notes: FORMULA: C2H8NS CHARGE: 1 INCHI: InChI=1S/C2H7NS/c3-1-2-4/h4H,1-3H2/p+1 HEPATONET_1.0_ABBREVIATION: HC00823 EHMN_ABBREVIATION: C01678
initial amount: NaN
name: cysteaminium
initial concentration: 1.0
boundary condition: false
type: Species
is: SBO:0000247
constant: false

http://identifiers.org/biomodels.db/MODEL1310110063#_1ab1de44_e00e_40b6_b593_a294ffea79ca
name: FH
boundary condition: true
is encoded by: hsa:2271
constant: false
initial concentration: NaN
has only substance units: false
is: P07954
is: SBO:0000252
initial amount: NaN
type: Species

metaR r2318
product: MODEL1310110063#
is described by: ECO:0000000
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
kinetic law: MODEL1310110063#
type: Reaction
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
fast: false
reactant: MODEL1310110063#
is: SBO:0000185

metaM HC02180 c
notes: FORMULA: C20H33O6 CHARGE: -1 INCHI: InChI=1S/C20H34O6/c1-2-3-6-9-15(21)12-13-18-16(17(22)14-20(25)26-18)10-7-4-5-8-11-19(23)24/h4,7,12-13,15-18,20-22,25H,2-3,5-6,8-11,14H2,1H3,(H,23,24)/b7-4-,13-12+/t15-,16-,17-,18+,20?/m0/s1 EHMN_ABBREVIATION: C05963
initial concentration: 1.0
initial amount: NaN
is: SBO:0000247
is: CHEBI:28728
type: Species
has only substance units: false
boundary condition: false
constant: false
name: thromboxane-b2

metaM HC02216 e
initial concentration: 1.0
name: prostaglandin-f2beta
boundary condition: false
notes: FORMULA: C20H33O5 CHARGE: -1 INCHI: InChI=1S/C20H34O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h4,7,12-13,15-19,21-23H,2-3,5-6,8-11,14H2,1H3,(H,24,25)/b7-4-,13-12+/t15-,16+,17+,18+,19+/m0/s1
is: SBO:0000247
type: Species
is: CHEBI:28922
constant: false
has only substance units: false
initial amount: NaN

metaR IPDDIx
fast: false
reactant: MODEL1310110063#
reversible: true
type: Reaction
is described by: ECO:0000134
modifier: MODEL1310110063#
is version of: http://identifiers.org/ec-code/5.3.3.2
name: isopentenyl-diphosphate D-isomerase
is: SBO:0000176
product: MODEL1310110063#
kinetic law: MODEL1310110063#
notes: GENE_ASSOCIATION: (3422.1) or (91734.1) SUBSYSTEM: Cholesterol metabolism EC Number: 5.3.3.2 Confidence Level: 4 AUTHORS: PMID:11111079 NOTES:peroxisomal version - NJ

metaR CSPG Atly
product: MODEL1310110063#
reversible: false
reactant: MODEL1310110063#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 2 AUTHORS: NOTES:
type: Reaction
is: SBO:0000185
name: chondroitin sulfate A transport, extracellular to lysosome
fast: false
kinetic law: MODEL1310110063#

metaR APRGSTRNte
kinetic law: MODEL1310110063#
type: Reaction
fast: false
is described by: ECO:0000000
product: MODEL1310110063#
is: SBO:0000185
reactant: MODEL1310110063#
reversible: true
name: hydroxyprogesterone transport
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 1 AUTHORS: NOTES:unknown mechanism NJ

metaM gluside hs g
initial concentration: 1.0
name: D-glucosyl-N-acylsphingosine
boundary condition: false
initial amount: NaN
constant: false
is: CHEBI:18368
type: Species
has only substance units: false
is: SBO:0000247
notes: FORMULA: C24H46NO7FULLRCO CHARGE: 0 EHMN_ABBREVIATION: C01190

metaM 4nphsf e
name: 4-Nitrophenyl sulfate
is: CHEBI:35422
notes: FORMULA: C6H4NO6S CHARGE: -1 INCHI: InChI=1S/C6H5NO6S/c8-7(9)5-1-3-6(4-2-5)13-14(10,11)12/h1-4H,(H,10,11,12)
initial concentration: 1.0
constant: false
type: Species
is: HMDB06492
has only substance units: false
is: SBO:0000247
initial amount: NaN
boundary condition: false

metaM cs b l
is: CHEBI:36005
name: chondroitin sulfate B / dermatan sulfate (IdoA2S-GalNAc4S), free chain
boundary condition: false
type: Species
initial concentration: 1.0
is: HMDB02183
constant: false
notes: FORMULA: C45H66N2O49S4 CHARGE: -6
is: SBO:0000247
initial amount: NaN
has only substance units: false

metaR r2319
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
fast: false
reactant: MODEL1310110063#
is: SBO:0000185
type: Reaction
product: MODEL1310110063#
reversible: true
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
kinetic law: MODEL1310110063#
is described by: ECO:0000000

metaM hs deg19 l
initial concentration: 1.0
initial amount: NaN
has only substance units: false
is: SBO:0000247
is: CHEBI:17180
constant: false
boundary condition: false
is: HMDB01352
type: Species
notes: FORMULA: C43H67N2O42S2 CHARGE: -3
name: heparan sulfate, degradation product 19

metaR RE0452M
product: MODEL1310110063#
reversible: true
kinetic law: MODEL1310110063#
reactant: MODEL1310110063#
is described by: ECO:0000000
name: RE0452
type: Reaction
is: SBO:0000176
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Pyrimidine synthesis EC Number: 2.7.4.9 Confidence Level: 0 AUTHORS: PMID:8024690 NOTES:

metaM c101coa c
initial concentration: 1.0
notes: FORMULA: C31H48N7O17P3S CHARGE: -4
is: SBO:0000247
initial amount: NaN
name: decenoylcoa
constant: false
has only substance units: false
type: Species
boundary condition: false
is: HMDB00651

http://identifiers.org/biomodels.db/MODEL1310110063#_eb77aad1_2644_4fec_922a_8c06d7c909d5
has only substance units: false
is: SBO:0000252
boundary condition: true
name: ABP1
is: P19801
initial concentration: NaN
is encoded by: hsa:26
type: Species
initial amount: NaN
constant: false

metaM dhcholestancoa x
is: HMDB02159
has only substance units: false
name: 3alpha,7alpha-Dihydroxy-5beta-cholestanoyl-CoA
initial concentration: 1.0
is: CHEBI:15494
boundary condition: false
notes: FORMULA: C48H76N7O19P3S CHARGE: -4 INCHI: InChI=1S/C48H80N7O19P3S/c1-26(30-10-11-31-36-32(13-16-48(30,31)6)47(5)15-12-29(56)20-28(47)21-33(36)57)8-7-9-27(2)45(62)78-19-18-50-35(58)14-17-51-43(61)40(60)46(3,4)23-71-77(68,69)74-76(66,67)70-22-34-39(73-75(63,64)65)38(59)44(72-34)55-25-54-37-41(49)52-24-53-42(37)55/h24-34,36,38-40,44,56-57,59-60H,7-23H2,1-6H3,(H,50,58)(H,51,61)(H,66,67)(H,68,69)(H2,49,52,53)(H2,63,64,65)/t26-,27?,28+,29-,30-,31+,32+,33-,34-,36+,38-,39-,40+,44-,47+,48-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01332 EHMN_ABBREVIATION: C04644
initial amount: NaN
constant: false
is: SBO:0000247
type: Species

metaM 4nphsf c
is: HMDB06492
has only substance units: false
type: Species
constant: false
is: SBO:0000247
is: CHEBI:35422
name: 4-Nitrophenyl sulfate
boundary condition: false
notes: FORMULA: C6H4NO6S CHARGE: -1 INCHI: InChI=1S/C6H5NO6S/c8-7(9)5-1-3-6(4-2-5)13-14(10,11)12/h1-4H,(H,10,11,12)
initial amount: NaN
initial concentration: 1.0

metaR EX c101crn
kinetic law: MODEL1310110063#
reactant: MODEL1310110063#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for decenoyl carnitine
type: Reaction

metaM pnto R e
boundary condition: false
initial amount: NaN
constant: false
type: Species
initial concentration: 1.0
is: CHEBI:7916
notes: FORMULA: C9H16NO5 CHARGE: -1 INCHI: InChI=1S/C9H17NO5/c1-9(2,5-11)7(14)8(15)10-4-3-6(12)13/h7,11,14H,3-5H2,1-2H3,(H,10,15)(H,12,13) HEPATONET_1.0_ABBREVIATION: HC00568
is: SBO:0000247
has only substance units: false
is: HMDB00210
name: (R)-Pantothenate

metaR C6CRNe
kinetic law: MODEL1310110063#
product: MODEL1310110063#
reactant: MODEL1310110063#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of hexanoyl carnitine into the extra cellular fluid
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110063#_4ce21621_14c4_429f_a15e_b0414f67861a
has only substance units: false
is: P37287
constant: false
initial amount: NaN
is encoded by: hsa:5277
name: PIGA
initial concentration: NaN
boundary condition: true
type: Species
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110063#_0cf02942_28a2_4c3e_ae47_2312408251f3
constant: false
boundary condition: true
is encoded by: hsa:594
is: SBO:0000297
initial concentration: NaN
initial amount: NaN
name: DBT:DLD:BCKDHA:BCKDHB
has only substance units: false
type: Species
has part: Q9BQL0

metaM HC02180 e
name: thromboxane-b2
initial concentration: 1.0
notes: FORMULA: C20H33O6 CHARGE: -1 INCHI: InChI=1S/C20H34O6/c1-2-3-6-9-15(21)12-13-18-16(17(22)14-20(25)26-18)10-7-4-5-8-11-19(23)24/h4,7,12-13,15-18,20-22,25H,2-3,5-6,8-11,14H2,1H3,(H,23,24)/b7-4-,13-12+/t15-,16-,17-,18+,20?/m0/s1 EHMN_ABBREVIATION: C05963
is: SBO:0000247
is: CHEBI:28728
type: Species
has only substance units: false
constant: false
initial amount: NaN
boundary condition: false

metaR C226CPT1
reactant: MODEL1310110063#
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/2.3.1.21
is: SBO:0000176
name: carnitine C22:6 transferase
notes: GENE_ASSOCIATION: (126129.1) or (1375.3) or (1374.1) or (1375.2) or (1375.1) or (1375.4) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.21 Confidence Level: 4 AUTHORS: PMID:1988962 NOTES:TDV
modifier: MODEL1310110063#
fast: false
kinetic law: MODEL1310110063#
product: MODEL1310110063#
type: Reaction
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110063#_f2abdfc7_380c_4324_91fa_35b0cd852550
boundary condition: true
is: SBO:0000252
initial concentration: NaN
is: O75354
name: ENTPD6
constant: false
initial amount: NaN
has only substance units: false
is encoded by: hsa:955
type: Species

metaR CYSALANaEx
is: SBO:0000185
kinetic law: MODEL1310110063#
product: MODEL1310110063#
fast: false
reactant: MODEL1310110063#
notes: GENE_ASSOCIATION: (6509.1) or (6510.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14530974 NOTES:SAB see Kanai and Hediger 2004 (2003), PMID 14530974
type: Reaction
reversible: false
name: L-alanine/L-cysteine Na-dependent exchange (Cys-L in)
modifier: MODEL1310110063#
is described by: ECO:0000269

metaR H2MTer U
reversible: false
is described by: ECO:0000000
kinetic law: MODEL1310110063#
product: MODEL1310110063#
modifier: MODEL1310110063#
type: Reaction
fast: false
notes: GENE_ASSOCIATION: (55650.1) SUBSYSTEM: Phosphatidylinositol phosphate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:15623507 NOTES:NCD
name: H2 mannosyltransferase, endoplasmic reticulum
is: SBO:0000176
reactant: MODEL1310110063#

http://identifiers.org/biomodels.db/MODEL1310110063#_753215bf_4b91_48c0_a277_1178dd8b9d11
is encoded by: hsa:23556
initial amount: NaN
is: SBO:0000252
constant: false
boundary condition: true
has only substance units: false
initial concentration: NaN
type: Species
name: PIGN

metaR DESAT16 2
notes: GENE_ASSOCIATION: (6319.1) SUBSYSTEM: Fatty acid synthesis EC Number: 1.14.19.1 Confidence Level: 4 AUTHORS: PMID:14967823 NOTES:for homo sapiens, noted to actually be NADH-cyt b5, using NADH at present NJ
is: SBO:0000176
is described by: ECO:0000000
type: Reaction
reactant: MODEL1310110063#
is version of: http://identifiers.org/ec-code/1.14.19.1
modifier: MODEL1310110063#
reversible: false
product: MODEL1310110063#
fast: false
name: palmitoyl-CoA desaturase (n-C16:0CoA -> n-C16:1CoA)
kinetic law: MODEL1310110063#

metaR r0009
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (AI990637.1) or (64077.1) or (5464.1) or (27068.1) SUBSYSTEM: Purine catabolism EC Number: 3.6.1.1 Confidence Level: 0 AUTHORS: PMID:10542310,PMID:16300924 NOTES:IT - fixed proton
kinetic law: MODEL1310110063#
name: Pyrophosphate phosphohydrolase EC:3.6.1.1
is version of: http://identifiers.org/ec-code/3.6.1.1
is: SBO:0000176
reactant: MODEL1310110063#
fast: false
type: Reaction
product: MODEL1310110063#
reversible: false
modifier: MODEL1310110063#

metaM 3hmbcoa m
initial concentration: 1.0
is: CHEBI:57312
is: SBO:0000247
has only substance units: false
constant: false
name: (2S,3S)-3-hydroxy-2-methylbutanoyl-CoA(4-)
boundary condition: false
initial amount: NaN
notes: FORMULA: C26H40N7O18P3S CHARGE: -4 INCHI: InChI=1S/C26H44N7O18P3S/c1-13(14(2)34)25(39)55-8-7-28-16(35)5-6-29-23(38)20(37)26(3,4)10-48-54(45,46)51-53(43,44)47-9-15-19(50-52(40,41)42)18(36)24(49-15)33-12-32-17-21(27)30-11-31-22(17)33/h11-15,18-20,24,34,36-37H,5-10H2,1-4H3,(H,28,35)(H,29,38)(H,43,44)(H,45,46)(H2,27,30,31)(H2,40,41,42)/p-4/t13-,14-,15+,18+,19+,20-,24+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01287 EHMN_ABBREVIATION: C04405
is: HMDB01356
type: Species

metaR C226CPT2
notes: GENE_ASSOCIATION: (1376.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: PMID:11274214,PMID:1528846,PMID:1988962 NOTES:TDV
is version of: http://identifiers.org/ec-code/2.3.1.21
fast: false
is described by: ECO:0000000
name: C226 transport into the mitochondria
is: SBO:0000176
kinetic law: MODEL1310110063#
product: MODEL1310110063#
modifier: MODEL1310110063#
reactant: MODEL1310110063#
type: Reaction
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110063#_b662aad0_fb85_4e91_aff3_aea37843e22b
is encoded by: hsa:5286
initial amount: NaN
has only substance units: false
name: PIK3C2A
constant: false
is: SBO:0000252
type: Species
is: O00443
initial concentration: NaN
boundary condition: true

metaM orn c
has only substance units: false
initial concentration: 1.0
is: C01602
is: HMDB00214
is: SBO:0000247
constant: false
initial amount: NaN
notes: FORMULA: C5H13N2O2 CHARGE: 1
name: Ornithine
is: CHEBI:0
boundary condition: false
type: Species

metaR EX phyt LPAREN e RPAREN
kinetic law: MODEL1310110063#
reactant: MODEL1310110063#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: phytanic acid exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110063#_0a708b91_06d9_495f_a027_7f3c2f5dcd4d
has only substance units: false
initial concentration: NaN
is: SBO:0000252
name: B3GALT5
initial amount: NaN
boundary condition: true
constant: false
is encoded by: hsa:10317
is: Q9Y2C3
type: Species

http://identifiers.org/biomodels.db/MODEL1310110063#_32d29a1a_ce92_4748_90bd_5f1d90071acc
boundary condition: true
name: ACADVL
constant: false
is encoded by: hsa:37
is: P49748
is: SBO:0000252
initial amount: NaN
initial concentration: NaN
has only substance units: false
type: Species

metaR UGT1A10r
product: MODEL1310110063#
is: SBO:0000176
name: UDP-glucuronosyltransferase 1-10 precursor, microsomal
reversible: true
fast: false
is version of: http://identifiers.org/ec-code/2.4.1.17
reactant: MODEL1310110063#
is described by: ECO:0000134
kinetic law: MODEL1310110063#
modifier: MODEL1310110063#
type: Reaction
notes: GENE_ASSOCIATION: (54576.1) SUBSYSTEM: Steroid metabolism EC Number: 2.4.1.17 Confidence Level: 1 AUTHORS: PMID:7945246 NOTES:bil is taken up by cell - made reversible (actual measurements of deltaG/reversibility not described in literature currently) NJ. rate of estradiol (alpha and beta) glucuronidation by human bilirubin UGT quantified

metaR FAOXC226
kinetic law: MODEL1310110063#
reversible: false
product: MODEL1310110063#
reactant: MODEL1310110063#
notes: GENE_ASSOCIATION: (35.1) or (34.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.99.3 Confidence Level: 4 AUTHORS: PMID:2565344,PMID:3035565 NOTES:TV Other enzymes: 1.3.3.6, 4.2.1.74, 4.2.1.17, 1.1.1.35, 1.1.1.211
is: SBO:0000176
name: Beta oxidation of long chain fatty acid
is version of: http://identifiers.org/ec-code/1.3.8.1
modifier: MODEL1310110063#
is version of: http://identifiers.org/ec-code/1.3.99.3
is described by: ECO:0000000
fast: false
type: Reaction

metaM CE5586 c
type: Species
name: N-[(E)-4-ammoniobutylidene]propane-1,3-diaminium
initial concentration: 1.0
notes: FORMULA: C7H20N3 CHARGE: 3 INCHI: InChI=1S/C7H17N3/c8-4-1-2-6-10-7-3-5-9/h6H,1-5,7-9H2/p+3/b10-6+ EHMN_ABBREVIATION: CE5586
is: CHEBI:58732
constant: false
has only substance units: false
initial amount: NaN
boundary condition: false
is: SBO:0000247

metaR EHGLATm
type: Reaction
is described by: ECO:0000212
kinetic law: MODEL1310110063#
reactant: MODEL1310110063#
reversible: false
is version of: http://identifiers.org/ec-code/2.6.1.1
fast: false
name: L-erythro-4-Hydroxyglutamate:2-oxoglutarate aminotransferase, mitochondrial
notes: GENE_ASSOCIATION: (2806.1) SUBSYSTEM: Arginine and Proline Metabolism EC Number: 2.6.1.1 Confidence Level: 1 AUTHORS: PMID:15849464 NOTES:NCD
modifier: MODEL1310110063#
is: SBO:0000176
product: MODEL1310110063#

metaM CE1944 c
has only substance units: false
is: CHEBI:36781
initial amount: NaN
notes: FORMULA: C4H8N CHARGE: 1 INCHI: InChI=1S/C4H7N/c1-2-4-5-3-1/h3H,1-2,4H2/p+1 EHMN_ABBREVIATION: CE1944
constant: false
initial concentration: 1.0
type: Species
name: 1-pyrrolinium
is: SBO:0000247
boundary condition: false

metaM ksi deg26 l
initial concentration: 1.0
has only substance units: false
notes: FORMULA: C110H179N7O93S4 CHARGE: -4
name: keratan sulfate I, degradation product 26
constant: false
is: CHEBI:58343
type: Species
boundary condition: false
is: HMDB00061
initial amount: NaN
is: SBO:0000247

metaM succoa m
boundary condition: false
initial amount: NaN
constant: false
notes: FORMULA: C25H35N7O19P3S CHARGE: -5 HEPATONET_1.0_ABBREVIATION: HC00093 EHMN_ABBREVIATION: C00091
initial concentration: 1.0
name: Succinyl-CoA
is: CHEBI:57292
is: SBO:0000247
has only substance units: false
type: Species
is: HMDB01022

http://identifiers.org/biomodels.db/MODEL1310110063#_bbc14fcd_bfe2_4cdc_b62b_37b1844cc6a5
has only substance units: false
constant: false
initial concentration: NaN
initial amount: NaN
name: _AI378339_1_m
is encoded by: hsa:AI378339
is: SBO:0000252
boundary condition: true
type: Species

metaM occoa c
initial concentration: 1.0
name: Octanoyl-CoA (n-C8:0CoA)
is: HMDB01070
initial amount: NaN
type: Species
boundary condition: false
notes: FORMULA: C29H46N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00869 EHMN_ABBREVIATION: C01944
is: CHEBI:57386
is: SBO:0000247
has only substance units: false
is: C01944
constant: false

metaM mi1345p c
is: CHEBI:57895
name: 1D-myo-inositol 1,3,4,5-tetrakisphosphate(8-)
notes: FORMULA: C6H8O18P4 CHARGE: -8 INCHI: InChI=1S/C6H16O18P4/c7-1-3(21-25(9,10)11)2(8)5(23-27(15,16)17)6(24-28(18,19)20)4(1)22-26(12,13)14/h1-8H,(H2,9,10,11)(H2,12,13,14)(H2,15,16,17)(H2,18,19,20)/p-8/t1-,2-,3-,4+,5-,6-/m0/s1 EHMN_ABBREVIATION: C01272
initial concentration: 1.0
is: SBO:0000247
type: Species
boundary condition: false
constant: false
is: HMDB01059
has only substance units: false
initial amount: NaN

metaR r2047
modifier: MODEL1310110063#
reactant: MODEL1310110063#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.15
type: Reaction
reversible: false
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
fast: false
is described by: ECO:0000000
is: SBO:0000185
product: MODEL1310110063#
kinetic law: MODEL1310110063#

metaR CDPDAGtm
reversible: true
type: Reaction
product: MODEL1310110063#
fast: false
name: intracellular transport
reactant: MODEL1310110063#
is described by: ECO:0000000
is: SBO:0000185
kinetic law: MODEL1310110063#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 1 AUTHORS: NOTES:unknown mechanism, presumed diffusion NJ

metaM m3mpdol U c
initial concentration: 1.0
constant: false
initial amount: NaN
is: CHEBI:37632
boundary condition: false
is: SBO:0000247
type: Species
has only substance units: false
notes: FORMULA: C1425H2340N20O370P20 CHARGE: -20
name: (alpha-D-mannosyl)3-beta-D-mannosyl-diacetylchitodiphosphodolichol, human uterine homolog

metaM gluside hs c
is: SBO:0000247
has only substance units: false
type: Species
notes: FORMULA: C24H46NO7FULLRCO CHARGE: 0 EHMN_ABBREVIATION: C01190
constant: false
initial concentration: 1.0
boundary condition: false
initial amount: NaN
name: D-glucosyl-N-acylsphingosine
is: CHEBI:18368

metaR ASPTAm
type: Reaction
product: MODEL1310110063#
notes: GENE_ASSOCIATION: (2806.1) SUBSYSTEM: Alanine and aspartate metabolism EC Number: 2.6.1.1 Confidence Level: 4 AUTHORS: PMID:6930651 NOTES:NCD
reactant: MODEL1310110063#
modifier: MODEL1310110063#
is: SBO:0000176
kinetic law: MODEL1310110063#
reversible: true
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/2.6.1.1
name: aspartate transaminase
fast: false

metaR FUCASEe
is described by: ECO:0000000
fast: false
reactant: MODEL1310110063#
product: MODEL1310110063#
is: SBO:0000176
reversible: false
is version of: http://identifiers.org/ec-code/3.2.1.51
notes: GENE_ASSOCIATION: (2519.1) SUBSYSTEM: N-glycan degradation EC Number: 3.2.1.51 Confidence Level: 0 AUTHORS: NOTES:NCD
name: alpha-fucosidase, extracellular
kinetic law: MODEL1310110063#
modifier: MODEL1310110063#
type: Reaction

metaM 3decdicoa m
is: http://identifiers.org/pubchem.compound/16019966
boundary condition: false
is: SBO:0000247
initial concentration: 1.0
type: Species
name: 3,7-decadienoylcoa
constant: false
notes: FORMULA: C31H46N7O17P3S CHARGE: -4
initial amount: NaN
has only substance units: false

metaM dctp n
boundary condition: false
constant: false
name: dCTP
notes: FORMULA: C9H12N3O13P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00367 EHMN_ABBREVIATION: C00458
has only substance units: false
initial amount: NaN
is: SBO:0000247
initial concentration: 1.0
is: CHEBI:16311
is: HMDB00998
is: C00458
type: Species

http://identifiers.org/biomodels.db/MODEL1310110063#_a7c470ba_9190_4446_85da_0727eef2a148
has only substance units: false
initial concentration: NaN
is: SBO:0000252
constant: false
initial amount: NaN
is: O15056
type: Species
name: SYNJ2
is encoded by: hsa:8871
boundary condition: true

metaR PROSTGD2t
kinetic law: MODEL1310110063#
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (6578.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12507753,PMID:8787677,PMID:9334206 NOTES:NJ
modifier: MODEL1310110063#
fast: false
type: Reaction
is: SBO:0000185
reversible: true
reactant: MODEL1310110063#
name: prostaglandin transport via bicarbonate countertransport
product: MODEL1310110063#

http://identifiers.org/biomodels.db/MODEL1310110063#_414462ef_cc90_470c_b528_1389bd2b5372
is: P30043
is encoded by: hsa:645
has only substance units: false
name: BLVRB
constant: false
is: SBO:0000252
initial amount: NaN
boundary condition: true
type: Species
initial concentration: NaN

metaM prostge1 c
boundary condition: false
has only substance units: false
is: HMDB01442
is: SBO:0000247
type: Species
initial concentration: 1.0
constant: false
initial amount: NaN
is: CHEBI:57397
name: prostaglandin E1(1-)
notes: FORMULA: C20H33O5 CHARGE: -1 INCHI: InChI=1S/C20H34O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h12-13,15-17,19,21,23H,2-11,14H2,1H3,(H,24,25)/p-1/b13-12+/t15-,16+,17+,19+/m0/s1 EHMN_ABBREVIATION: C04741

http://identifiers.org/biomodels.db/MODEL1310110063#_683b21ce_3ad5_4731_8856_36bd4cbdb8b9
is: Q5K4L6
type: Species
initial concentration: NaN
constant: false
name: SLC27A3
initial amount: NaN
boundary condition: true
is: SBO:0000252
is encoded by: hsa:11000
has only substance units: false

metaR FACOAL170
reversible: true
product: MODEL1310110063#
reactant: MODEL1310110063#
notes: GENE_ASSOCIATION: (22305.2) or (2182.1) or (2180.1) or (2181.2) or (2181.1) or (22305.1) SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 4 AUTHORS: PMID:15292367 NOTES:AR
is: SBO:0000176
kinetic law: MODEL1310110063#
type: Reaction
modifier: MODEL1310110063#
is version of: http://identifiers.org/ec-code/6.2.1.3
name: fatty-acid--CoA ligase
is described by: ECO:0000000
fast: false

metaM nad c
initial concentration: 1.0
is: http://identifiers.org/pubchem.compound/3305
type: Species
is: SBO:0000247
constant: false
name: Nicotinamide adenine dinucleotide
is: HMDB00902
is: CHEBI:57540
initial amount: NaN
is: C00003
boundary condition: false
has only substance units: false

metaM lnlncg r
notes: FORMULA: C18H29O2 CHARGE: -1 INCHI: InChI=1S/C18H30O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20/h6-7,9-10,12-13H,2-5,8,11,14-17H2,1H3,(H,19,20)/p-1/b7-6-,10-9-,13-12- HEPATONET_1.0_ABBREVIATION: HC01757 EHMN_ABBREVIATION: C06426
is: SBO:0000247
has only substance units: false
initial amount: NaN
constant: false
type: Species
boundary condition: false
name: gamma-linolenate
is: HMDB03073
is: CHEBI:32391
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110063#_afe9ac36_9ae0_490d_b840_d9598d8140e3
boundary condition: true
has only substance units: false
initial concentration: NaN
is encoded by: hsa:2821
constant: false
is: SBO:0000252
is: P06744
name: GPI
type: Species
initial amount: NaN

metaM ksi deg22 l
notes: FORMULA: C132H214N9O111S5 CHARGE: -5
is: HMDB01354
initial concentration: 1.0
is: CHEBI:57455
name: keratan sulfate I, degradation product 22
type: Species
has only substance units: false
initial amount: NaN
boundary condition: false
constant: false
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110063#_9d753b4b_6123_4229_ad51_0a7e5197d936
is: GO:0005777
is: SBO:0000290
constant: false
size: 1.0
spatial dimensions: 3.0
name: peroxisome
type: Compartment

metaR LNELDCCRNt
product: MODEL1310110063#
name: transport into the mitochondria (carnitine)
is: SBO:0000185
notes: GENE_ASSOCIATION: (788.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: NOTES:NJ
kinetic law: MODEL1310110063#
is described by: ECO:0000000
modifier: MODEL1310110063#
type: Reaction
reversible: false
fast: false
reactant: MODEL1310110063#

http://identifiers.org/biomodels.db/MODEL1310110063#_44be71ff_e0b2_433c_86c8_00c3046b3fd9
constant: false
is encoded by: hsa:224
has only substance units: false
initial concentration: NaN
is: P51648
type: Species
boundary condition: true
name: ALDH3A2
is: SBO:0000252
initial amount: NaN

metaR EX 3mop LPAREN e RPAREN
kinetic law: MODEL1310110063#
reactant: MODEL1310110063#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: Exchange of 3-methyl-2-oxopentanoate
type: Reaction

metaM dtdp n
boundary condition: false
has only substance units: false
is: SBO:0000247
type: Species
initial concentration: 1.0
initial amount: NaN
notes: FORMULA: C10H13N2O11P2 CHARGE: -3 INCHI: InChI=1S/C10H16N2O11P2/c1-5-3-12(10(15)11-9(5)14)8-2-6(13)7(22-8)4-21-25(19,20)23-24(16,17)18/h3,6-8,13H,2,4H2,1H3,(H,19,20)(H,11,14,15)(H2,16,17,18)/p-3/t6-,7+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00307 EHMN_ABBREVIATION: C00363
constant: false
name: ({[(2R,3S,5R)-3-hydroxy-5-(5-methyl-2,4-dioxo-1,2,3,4-tetrahydropyrimidin-1-yl)oxolan-2-yl]methyl phosphonato}oxy)phosphonate
is: HMDB01274
is: CHEBI:58369

metaM hs deg17 l
is: CHEBI:21338
notes: FORMULA: C43H65N2O48S4 CHARGE: -5
name: heparan sulfate, degradation product 17
type: Species
boundary condition: false
is: SBO:0000247
initial amount: NaN
initial concentration: 1.0
has only substance units: false
is: HMDB02704
constant: false

http://identifiers.org/biomodels.db/MODEL1310110063#_5a52777f_c00b_42a3_b015_9c430dcf32dc
is: A6NDW6
initial concentration: NaN
name: ALG8
constant: false
has only substance units: false
type: Species
boundary condition: true
initial amount: NaN
is: SBO:0000252
is encoded by: hsa:79053

metaM prostge1 e
notes: FORMULA: C20H33O5 CHARGE: -1 INCHI: InChI=1S/C20H34O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h12-13,15-17,19,21,23H,2-11,14H2,1H3,(H,24,25)/p-1/b13-12+/t15-,16+,17+,19+/m0/s1 EHMN_ABBREVIATION: C04741
name: prostaglandin E1(1-)
boundary condition: false
is: CHEBI:57397
is: SBO:0000247
initial amount: NaN
type: Species
has only substance units: false
constant: false
is: HMDB01442
initial concentration: 1.0

metaR NACHEX19ly
is version of: http://identifiers.org/ec-code/3.2.1.52
is: SBO:0000176
type: Reaction
modifier: MODEL1310110063#
kinetic law: MODEL1310110063#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (3074.1) or (3073.1 and 3074.1) or (3073.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.52 Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12706724,PMID:8993162 NOTES:NCD
reversible: false
reactant: MODEL1310110063#
name: beta-N-acetylhexosaminidase, lysosomal
fast: false
product: MODEL1310110063#

metaM retinal r
constant: false
is: HMDB01358
initial concentration: 1.0
has only substance units: false
is: SBO:0000247
name: retinal
notes: FORMULA: C20H28O CHARGE: 0 INCHI: InChI=1S/C20H28O/c1-16(8-6-9-17(2)13-15-21)11-12-19-18(3)10-7-14-20(19,4)5/h6,8-9,11-13,15H,7,10,14H2,1-5H3 EHMN_ABBREVIATION: C00376
is: CHEBI:15035
type: Species
boundary condition: false
initial amount: NaN

metaM cholcoa x
notes: FORMULA: C45H70N7O20P3S CHARGE: -4 INCHI: InChI=1S/C45H74N7O20P3S/c1-23(26-7-8-27-34-28(18-31(55)45(26,27)5)44(4)12-10-25(53)16-24(44)17-29(34)54)6-9-33(57)76-15-14-47-32(56)11-13-48-41(60)38(59)43(2,3)20-69-75(66,67)72-74(64,65)68-19-30-37(71-73(61,62)63)36(58)42(70-30)52-22-51-35-39(46)49-21-50-40(35)52/h21-31,34,36-38,42,53-55,58-59H,6-20H2,1-5H3,(H,47,56)(H,48,60)(H,64,65)(H,66,67)(H2,46,49,50)(H2,61,62,63)/p-4/t23-,24+,25-,26-,27+,28+,29-,30-,31+,34+,36-,37-,38+,42-,44+,45-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00844 EHMN_ABBREVIATION: C01794
constant: false
is: SBO:0000247
type: Species
initial concentration: 1.0
name: choloyl-CoA(4-)
initial amount: NaN
is: HMDB01374
has only substance units: false
boundary condition: false
is: CHEBI:57373

metaR NDP3ex
type: Reaction
product: MODEL1310110063#
notes: GENE_ASSOCIATION: (124583.1) SUBSYSTEM: Nucleotide interconversion EC Number: 3.6.1.6 Confidence Level: 4 AUTHORS: PMID:12234496,PMID:12600208 NOTES:EC is 3.6.1.42? NCD
is version of: http://identifiers.org/ec-code/3.6.1.6
reversible: false
is: SBO:0000176
is described by: ECO:0000269
kinetic law: MODEL1310110063#
modifier: MODEL1310110063#
name: nucleoside-diphosphatase (GDP), extracellular
fast: false
reactant: MODEL1310110063#

http://identifiers.org/biomodels.db/MODEL1310110063#_521c7ec0_ccea_40e2_9394_00acb584d439
has only substance units: false
constant: false
type: Species
initial concentration: NaN
is encoded by: hsa:51733
boundary condition: true
name: UPB1
is: SBO:0000252
is: B3KNC1
initial amount: NaN

metaM ile L m
constant: false
has only substance units: false
is: SBO:0000247
is: CHEBI:17191
type: Species
boundary condition: false
notes: FORMULA: C6H13NO2 CHARGE: 0 INCHI: InChI=1S/C6H13NO2/c1-3-4(2)5(7)6(8)9/h4-5H,3,7H2,1-2H3,(H,8,9)/t4-,5-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00334 EHMN_ABBREVIATION: C00407
name: L-isoleucine
is: HMDB00172
initial amount: NaN
initial concentration: 1.0

metaM gacpail hs r
type: Species
notes: FORMULA: C31H58NO14PFULLRCO2FULLR2CO2 CHARGE: 0
initial concentration: 1.0
constant: false
is: HMDB01401
boundary condition: false
has only substance units: false
initial amount: NaN
is: SBO:0000247
name: glucosaminyl-acylphosphatidylinositol
is: C00092
is: CHEBI:61548

metaR RE1520M
name: RE1520
product: MODEL1310110063#
type: Reaction
modifier: MODEL1310110063#
notes: GENE_ASSOCIATION: (1892.1) or (3030.1) or (1962.1) or (3032.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.17 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:7923814,PMID:9568246,PMID:9920399 NOTES:
is: SBO:0000176
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/2.3.1.16
reactant: MODEL1310110063#
kinetic law: MODEL1310110063#
reversible: true
is version of: http://identifiers.org/ec-code/4.2.1.17
is version of: http://identifiers.org/ec-code/1.1.1.35
fast: false

metaR r0671
product: MODEL1310110063#
reversible: false
kinetic law: MODEL1310110063#
is version of: http://identifiers.org/ec-code/3.2.1.22
name: (R)-4-Phosphopantothenate:L-cysteine ligase EC:6.3.2.5
is: SBO:0000176
fast: false
notes: GENE_ASSOCIATION: (2717.1) or (6173.1) SUBSYSTEM: CoA synthesis EC Number: 6.3.2.5 Confidence Level: 0 AUTHORS: PMID:11923312,PMID:12906824,PMID:15893380 NOTES:
modifier: MODEL1310110063#
type: Reaction
is described by: ECO:0000000
reactant: MODEL1310110063#

metaR A4GALTg
fast: false
is described by: ECO:0000269
type: Reaction
name: Lactosylceramide 4-alpha-galactosyltransferase
reversible: false
modifier: MODEL1310110063#
kinetic law: MODEL1310110063#
is: SBO:0000176
notes: GENE_ASSOCIATION: (53947.1) SUBSYSTEM: Sphingolipid metabolism EC Number: 2.4.1.228 Confidence Level: 4 AUTHORS: PMID:10747952,PMID:10748143 NOTES:EC: 2.4.1.228 NJ
is version of: http://identifiers.org/ec-code/2.4.1.228
reactant: MODEL1310110063#
product: MODEL1310110063#

metaR FAOXC61x
kinetic law: MODEL1310110063#
product: MODEL1310110063#
reactant: MODEL1310110063#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: isomerization(C6:1)x
type: Reaction

metaM 3tdcrn c
name: 3-hydroxy-tetradecanoyl carnitine
is: HMDB02014
is: SBO:0000247
has only substance units: false
initial concentration: 1.0
initial amount: NaN
constant: false
boundary condition: false
type: Species
notes: FORMULA: C21H41NO5 CHARGE: 0

metaR N3Tg
modifier: MODEL1310110063#
is version of: http://identifiers.org/ec-code/2.4.1.122
is described by: ECO:0000000
reactant: MODEL1310110063#
notes: GENE_ASSOCIATION: (56913.1) SUBSYSTEM: O-glycan synthesis EC Number: 2.4.1.122 Confidence Level: 0 AUTHORS: PMID:11677243 NOTES:NCD
name: N-acetylgalactosamine 3-beta-galactosyltransferase, Golgi apparatus
is: SBO:0000176
kinetic law: MODEL1310110063#
product: MODEL1310110063#
type: Reaction
fast: false
reversible: false

metaR EX ptrc LPAREN e RPAREN
kinetic law: MODEL1310110063#
reactant: MODEL1310110063#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of 1,4-butanediammonium
type: Reaction

metaR FAOXC185m
kinetic law: MODEL1310110063#
product: MODEL1310110063#
reactant: MODEL1310110063#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: isomerization(C18:5)m
type: Reaction

metaR FAOXC102C103m
kinetic law: MODEL1310110063#
product: MODEL1310110063#
reactant: MODEL1310110063#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C10:2-->C10:3)m
type: Reaction

metaM omhpal r
is: SBO:0000247
notes: FORMULA: C16H30O3 CHARGE: -1
type: Species
has only substance units: false
is: HMDB06294
name: w-hydroxypalmiticacid
initial concentration: 1.0
boundary condition: false
constant: false
initial amount: NaN

metaR EX C04849 LPAREN e RPAREN
kinetic law: MODEL1310110063#
reactant: MODEL1310110063#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: (5Z,9E,14Z)-(8xi,11R,12S)-11,12-epoxy-8-hydroxyicosa-5,9,14-trienoate exchange
type: Reaction

metaM gluala e
initial amount: NaN
is: C03740
notes: FORMULA: C8H13N2O5 CHARGE: -1 INCHI: InChI=1/C8H14N2O5/c1-4(7(12)13)10-6(11)3-2-5(9)8(14)15/h4-5H,2-3,9H2,1H3,(H,10,11)(H,12,13)(H,14,15)/t4-,5-/m0/s1 EHMN_ABBREVIATION: C03740
is: SBO:0000247
is: HMDB06248
name: 5-L-Glutamyl-L-alanine
constant: false
initial concentration: 1.0
is: http://identifiers.org/pubchem.compound/6503
boundary condition: false
type: Species
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110063#_612ced0e_a184_443b_b08e_0bbbfb127161
boundary condition: true
is: SBO:0000252
is encoded by: hsa:4882
type: Species
initial amount: NaN
has only substance units: false
name: NPR2
constant: false
initial concentration: NaN

metaR r2310
reactant: MODEL1310110063#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14579113 NOTES:
is: SBO:0000185
is described by: ECO:0000000
reversible: true
product: MODEL1310110063#
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.14
type: Reaction
kinetic law: MODEL1310110063#
fast: false

metaR P45027A11m
kinetic law: MODEL1310110063#
is described by: ECO:0000269
modifier: MODEL1310110063#
notes: GENE_ASSOCIATION: (1593.1) SUBSYSTEM: Bile acid synthesis EC Number: 1.14.13.15 Confidence Level: 4 AUTHORS: NOTES:from uniprot NJ
type: Reaction
reversible: false
is: SBO:0000176
name: 5-beta-cholestane-3-alpha,7-alpha,12-alpha-triol 27-hydroxylase
reactant: MODEL1310110063#
is version of: http://identifiers.org/ec-code/1.14.13.15
product: MODEL1310110063#
fast: false

metaR RE3628M
reactant: MODEL1310110063#
is version of: http://identifiers.org/ec-code/1.1.1.35
is version of: http://identifiers.org/ec-code/5.3.3.8
reversible: true
name: RE3628
is: SBO:0000176
notes: GENE_ASSOCIATION: (1632.1) or (10455.1) or (1962.1) SUBSYSTEM: Fatty acid oxidation EC Number: 5.3.3.8 Confidence Level: 0 AUTHORS: PMID:11356164,PMID:7775433 NOTES:
fast: false
type: Reaction
product: MODEL1310110063#
is described by: ECO:0000000
modifier: MODEL1310110063#
kinetic law: MODEL1310110063#

http://identifiers.org/biomodels.db/MODEL1310110063#_88326080_74ac_4a85_8538_5577d0a7c283
has only substance units: false
initial concentration: NaN
constant: false
initial amount: NaN
is: SBO:0000252
is: Q16706
name: MAN2A1
type: Species
boundary condition: true
is encoded by: hsa:4124

metaM ksii core2 deg3 l
boundary condition: false
is: SBO:0000247
initial amount: NaN
constant: false
initial concentration: 1.0
is: HMDB00143
type: Species
name: keratan sulfate II (core 2-linked), degradation product 3
notes: FORMULA: C58H94N5O46S2X CHARGE: -2
has only substance units: false
is: CHEBI:12936

metaM dtdp m
is: HMDB01274
name: dTDP
is: C00363
initial concentration: 1.0
constant: false
initial amount: NaN
has only substance units: false
is: SBO:0000247
boundary condition: false
notes: FORMULA: C10H13N2O11P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00307 EHMN_ABBREVIATION: C00363
is: CHEBI:58369
type: Species

http://identifiers.org/biomodels.db/MODEL1310110063#_78bc4556_423e_40f8_aa6d_baab2b87179a
is encoded by: hsa:2530
type: Species
constant: false
is: Q9BYC5
initial concentration: NaN
has only substance units: false
boundary condition: true
name: FUT8
is: SBO:0000252
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110063#_9373098d_9ca9_4f3e_aa1e_b76f6a0674fa
is: SBO:0000252
has only substance units: false
initial amount: NaN
name: PLCD1
initial concentration: NaN
constant: false
is encoded by: hsa:5333
boundary condition: true
type: Species
is: P51178

metaR ADNCYC
fast: false
reactant: MODEL1310110063#
reversible: false
notes: GENE_ASSOCIATION: (112.1) or (55811.1) or (109.1) or (112.2) or (114.1) or (108.1) or (113.1) or (107.1) or (196883.1) or (115.1) or (111.1) SUBSYSTEM: Nucleotide interconversion EC Number: 4.6.1.1 Confidence Level: 4 AUTHORS: PMID:10481931,PMID:11299302,PMID:11423534,PMID:11840511,PMID:12503609,PMID:12609998,PMID:12623444,PMID:1427768,PMID:14996950,PMID:15547246,PMID:7860067,PMID:7959689,PMID:8076676 NOTES:JLR
kinetic law: MODEL1310110063#
product: MODEL1310110063#
modifier: MODEL1310110063#
type: Reaction
is described by: ECO:0000269
name: adenylate cyclase
is version of: http://identifiers.org/ec-code/4.6.1.1
is: SBO:0000176

metaR PIACGT
modifier: MODEL1310110063#
is version of: http://identifiers.org/ec-code/2.4.1.198
reactant: MODEL1310110063#
product: MODEL1310110063#
type: Reaction
name: phosphatidylinositol N-acetylglucosaminyltransferase
fast: false
kinetic law: MODEL1310110063#
is version of: http://identifiers.org/ec-code/2.4.1.83
is: SBO:0000176
notes: GENE_ASSOCIATION: (5279.1) and (51227.2) and (5283.1) and (5277.2) and (9091.1) and (8818.1) or (5279.1) and (51227.2) and (5283.1) and (9091.1) and (5277.2) and (8818.1) or (51227.1) and (9091.2) and (5277.3) and (5283.1) and (5279.2) and (8818.1) or (51227.2) and (5277.1) and (5283.1) and (9091.1) and (8818.2) and (5279.2) or (51227.3) and (9091.2) and (5277.3) and (5283.1) and (5279.2) and (8818.1) or (5279.1) and (51227.1) and (9091.2) and (5277.1) and (5283.1) and (8818.2) or (51227.3) and (9091.2) and (5277.1) and (5283.1) and (5279.2) and (8818.1) or (51227.1) and (9091.2) and (5277.1) and (5283.1) and (8818.1) and (5279.2) or (51227.3) and (9091.2) and (5277.3) and (5283.1) and (5279.2) and (8818.2) or (51227.1) and (5277.1) and (5283.1) and (9091.1) and (5279.2) and (8818.1) or (51227.2) and (5283.1) and (9091.1) and (5277.2) and (8818.1) and (5279.2) or (5279.1) and (51227.1) and (9091.2) and (5277.3) and (5283.1) and (8818.2) or (51227.3) and (9091.2) and (5277.1) and (5283.1) and (8818.2) and (5279.2) or (5279.1) and (51227.2) and (5277.3) and (5283.1) and (9091.1) and (8818.2) or (51227.1) and (5277.3) and (5283.1) and (9091.1) and (8818.1) and (5279.2) or (51227.2) and (5277.1) and (5283.1) and (9091.1) and (8818.1) and (5279.2) or (5279.1) and (51227.2) and (9091.2) and (5277.1) and (5283.1) and (8818.1) or (5279.1) and (51227.1) and (9091.2) and (5283.1) and (5277.2) and (8818.2) or (5279.1) and (9091.2) and (51227.2) and (5277.2) and (5283.1) and (8818.2) or (5279.1) and (9091.2) and (51227.2) and (5277.1) and (5283.1) and (8818.2) or (51227.3) and (5283.1) and (5277.2) and (9091.1) and (8818.1) and (5279.2) or (51227.2) and (5277.3) and (5283.1) and (9091.1) and (8818.1) and (5279.2) or (5279.1) and (51227.1) and (5283.1) and (5277.2) and (9091.1) and (8818.2) or (51227.3) and (9091.2) and (5283.1) and (5277.2) and (5279.2) and (8818.1) or (5279.1) and (51227.3) and (9091.2) and (5283.1) and (5277.2) and (8818.2) or (51227.1) and (9091.2) and (5277…
is described by: ECO:0000000
reversible: false

metaR EX 7dhf LPAREN e RPAREN
kinetic law: MODEL1310110063#
reactant: MODEL1310110063#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: heptaglutamyl folate (DHF) exchange
type: Reaction

metaR 2HBt2
fast: false
notes: GENE_ASSOCIATION: (9123.1) or (9194.1) or (6566.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10510291,PMID:11101640,PMID:12739169,PMID:7835905,PMID:8476015,PMID:9425115,PMID:9508842,PMID:9649795,PMID:9786900,PMID:9824713 NOTES:NCD
type: Reaction
modifier: MODEL1310110063#
reversible: true
kinetic law: MODEL1310110063#
reactant: MODEL1310110063#
name: 2-hydroxybutyrate cotransport with proton
is described by: ECO:0000269
product: MODEL1310110063#
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110063#_f7213292_ee31_429c_a920_478c7e316c4b
initial amount: NaN
boundary condition: true
is encoded by: hsa:6649
initial concentration: NaN
is: P08294
has only substance units: false
type: Species
is: SBO:0000252
constant: false
name: SOD3

metaM retinol cis 11 c
has only substance units: false
is: HMDB06216
constant: false
type: Species
is: SBO:0000247
boundary condition: false
notes: FORMULA: C20H30O CHARGE: 0 INCHI: InChI=1S/C20H30O/c1-16(8-6-9-17(2)13-15-21)11-12-19-18(3)10-7-14-20(19,4)5/h6,8-9,11-13,21H,7,10,14-15H2,1-5H3/b9-6-,12-11+,16-8+,17-13+
initial concentration: 1.0
name: 11-cis-retinol
is: CHEBI:16302
initial amount: NaN

metaR THMMPtm
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: PMID:12014993,PMID:9755848 NOTES:IT
is described by: ECO:0000000
reversible: true
product: MODEL1310110063#
fast: false
type: Reaction
name: Thiamine monophosphate transport, mitochondrial
reactant: MODEL1310110063#
kinetic law: MODEL1310110063#
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110063#_59a0005a_7615_487e_8ae0_5ff74d0a0fcd
type: Species
is encoded by: hsa:6530
has only substance units: false
is: Q96KH8
constant: false
is: SBO:0000252
initial concentration: NaN
initial amount: NaN
boundary condition: true
name: SLC6A2

http://identifiers.org/biomodels.db/MODEL1310110063#_7f1a8bc2_c195_478d_ba2c_5721ac597d97
is encoded by: hsa:AI480132
initial concentration: NaN
type: Species
constant: false
boundary condition: true
has only substance units: false
initial amount: NaN
is: SBO:0000252
name: _AI480132_1_c

metaR r2311
is described by: ECO:0000000
reversible: true
kinetic law: MODEL1310110063#
fast: false
reactant: MODEL1310110063#
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.14
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14579113 NOTES:
is: SBO:0000185
product: MODEL1310110063#

metaR GDPFUCtg
notes: GENE_ASSOCIATION: (55343.1) SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 4 AUTHORS: PMID:11326279,PMID:11326280 NOTES:NCD
reactant: MODEL1310110063#
is described by: ECO:0000269
type: Reaction
is: SBO:0000185
kinetic law: MODEL1310110063#
modifier: MODEL1310110063#
product: MODEL1310110063#
fast: false
reversible: true
name: GDPFuc Golgi transport via CMP antiport

metaM 3tdcrn e
is: SBO:0000247
initial amount: NaN
name: 3-hydroxy-tetradecanoyl carnitine
constant: false
initial concentration: 1.0
has only substance units: false
is: HMDB13336
boundary condition: false
type: Species
notes: FORMULA: C21H41NO5 CHARGE: 0

metaR G12MT1 U
is: SBO:0000176
fast: false
reactant: MODEL1310110063#
product: MODEL1310110063#
notes: GENE_ASSOCIATION: SUBSYSTEM: N-glycan synthesis EC Number: 2.4.1.131 Confidence Level: 0 AUTHORS: NOTES:
name: Glycolipid 1,2-alpha-D-mannosyltransferase (uterus)
is described by: ECO:0000000
kinetic law: MODEL1310110063#
type: Reaction
reversible: false

metaR r2045
reversible: false
product: MODEL1310110063#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.15
fast: false
is: SBO:0000185
reactant: MODEL1310110063#
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
type: Reaction
is described by: ECO:0000000
modifier: MODEL1310110063#
kinetic law: MODEL1310110063#

http://identifiers.org/biomodels.db/MODEL1310110063#_9e0dfa45_fd42_445d_8a57_bbc677d0ed74
is: P08842
boundary condition: true
initial concentration: NaN
name: STS
is encoded by: hsa:412
has only substance units: false
constant: false
type: Species
is: SBO:0000252
initial amount: NaN

metaR RE0688E
fast: false
modifier: MODEL1310110063#
is: SBO:0000176
reversible: false
type: Reaction
notes: GENE_ASSOCIATION: (26.1) SUBSYSTEM: Urea cycle EC Number: 1.4.3.6 Confidence Level: 0 AUTHORS: PMID:10047787,PMID:7040832 NOTES:
product: MODEL1310110063#
is version of: http://identifiers.org/ec-code/1.4.3.22
kinetic law: MODEL1310110063#
is described by: ECO:0000000
reactant: MODEL1310110063#
name: RE0688

metaR CYTK3n
kinetic law: MODEL1310110063#
modifier: MODEL1310110063#
product: MODEL1310110063#
is version of: http://identifiers.org/ec-code/2.7.4.14
reactant: MODEL1310110063#
is described by: ECO:0000269
is: SBO:0000176
fast: false
type: Reaction
name: cytidylate kinase (dCMP,CTP),nuclear
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
reversible: true

metaR r2312
kinetic law: MODEL1310110063#
is: SBO:0000185
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14579113 NOTES:
reversible: true
type: Reaction
product: MODEL1310110063#
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.14
reactant: MODEL1310110063#
fast: false

metaR r0002
product: MODEL1310110063#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:10460205,PMID:1296165,PMID:16288981,PMID:17466261,PMID:2199597,PMID:6219439,PMID:6361812,PMID:8353366 NOTES:
reversible: true
reactant: MODEL1310110063#
fast: false
is described by: ECO:0000000
kinetic law: MODEL1310110063#
name: Active transport
is: SBO:0000185
type: Reaction

metaM prpncoa m
type: Species
name: acryloyl-CoA(4-)
initial amount: NaN
has only substance units: false
initial concentration: 1.0
is: CHEBI:57367
boundary condition: false
is: SBO:0000247
constant: false
notes: FORMULA: C24H34N7O17P3S CHARGE: -4 INCHI: InChI=1S/C24H38N7O17P3S/c1-4-15(33)52-8-7-26-14(32)5-6-27-22(36)19(35)24(2,3)10-45-51(42,43)48-50(40,41)44-9-13-18(47-49(37,38)39)17(34)23(46-13)31-12-30-16-20(25)28-11-29-21(16)31/h4,11-13,17-19,23,34-35H,1,5-10H2,2-3H3,(H,26,32)(H,27,36)(H,40,41)(H,42,43)(H2,25,28,29)(H2,37,38,39)/p-4/t13-,17-,18-,19+,23-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00579 EHMN_ABBREVIATION: C00894
is: HMDB02307

metaR GNDer
reactant: MODEL1310110063#
product: MODEL1310110063#
name: phosphogluconate dehydrogenase, endoplasmic reticulum
notes: GENE_ASSOCIATION: SUBSYSTEM: Pentose phosphate pathway EC Number: 1.1.1.44 Confidence Level: 4 AUTHORS: PMID:2156506 NOTES:SMP Note no proton generation by the the reaction NCD
fast: false
kinetic law: MODEL1310110063#
is described by: ECO:0000000
type: Reaction
is: SBO:0000176
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110063#_4395623a_4902_4cdc_b7fc_dcb1577741a6
constant: false
is: B2RDZ2
initial amount: NaN
boundary condition: true
has only substance units: false
name: RFK
is: SBO:0000252
initial concentration: NaN
type: Species
is encoded by: hsa:55312

http://identifiers.org/biomodels.db/MODEL1310110063#_0b529e1e_55bd_4cae_b355_31d042f5a76f
is: Q549M5
constant: false
initial concentration: NaN
type: Species
has only substance units: false
initial amount: NaN
boundary condition: true
is: SBO:0000252
is encoded by: hsa:4718
name: NDUFC2

metaR APOCFm
type: Reaction
kinetic law: MODEL1310110063#
reversible: false
fast: false
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Biotin metabolism EC Number: Confidence Level: 2 AUTHORS: NOTES:IT faked reaction to balance reaction in human biotin metabolism
product: MODEL1310110063#
is: SBO:0000176
reactant: MODEL1310110063#
name: Apocarboxylase formation, mitochondrial

metaM CE2418 m
is: SBO:0000247
type: Species
initial concentration: 1.0
has only substance units: false
is: CHEBI:28387
boundary condition: false
name: (3S)-3-hydroxy-cis,cis-palmito-7,10-dienoyl-CoA
notes: FORMULA: C37H58N7O18P3S CHARGE: -4 INCHI: InChI=1/C37H62N7O18P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-25(45)20-28(47)66-19-18-39-27(46)16-17-40-35(50)32(49)37(2,3)22-59-65(56,57)62-64(54,55)58-21-26-31(61-63(51,52)53)30(48)36(60-26)44-24-43-29-33(38)41-23-42-34(29)44/h8-9,11-12,23-26,30-32,36,45,48-49H,4-7,10,13-22H2,1-3H3,(H,39,46)(H,40,50)(H,54,55)(H,56,57)(H2,38,41,42)(H2,51,52,53)/p-4/b9-8-,12-11-/t25-,26-,30+,31+,32u,36-/m0/s1 EHMN_ABBREVIATION: CE2418
is: HMDB11123
constant: false
initial amount: NaN

metaR r2313
product: MODEL1310110063#
reversible: true
reactant: MODEL1310110063#
fast: false
type: Reaction
kinetic law: MODEL1310110063#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110063#_280875ba_9cb6_4fcd_8e4c_1a578ec03e02
initial concentration: NaN
name: AMY1B
is: P04745
type: Species
constant: false
is encoded by: hsa:277
has only substance units: false
initial amount: NaN
is: SBO:0000252
boundary condition: true

metaM mercplaccys c
initial concentration: 1.0
name: 3-mercaptolactate-cysteine disulfide
boundary condition: false
is: HMDB06512
notes: FORMULA: C6H10O5S2N CHARGE: -1 INCHI: InChI=1/C6H11NO5S2/c7-3(5(9)10)1-13-14-2-4(8)6(11)12/h3-4,8H,1-2,7H2,(H,9,10)(H,11,12)/t3-,4?/m0/s1
has only substance units: false
initial amount: NaN
constant: false
type: Species
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110063#_f2a6c261_6cda_4ea8_b20b_13e05e156f50
is: Q8WYR1
name: PIK3R5
initial concentration: NaN
is: SBO:0000252
has only substance units: false
constant: false
initial amount: NaN
type: Species
is encoded by: hsa:23533
boundary condition: true

metaM succoa c
notes: FORMULA: C25H35N7O19P3S CHARGE: -5
constant: false
initial amount: NaN
is: SBO:0000247
has only substance units: false
name: Succinyl-CoA
type: Species
is: HMDB01022
boundary condition: false
initial concentration: 1.0

metaM 3mob e
is: SBO:0000247
name: 3-methyl-2-oxobutanoate
initial amount: NaN
initial concentration: 1.0
is: CHEBI:11851
constant: false
boundary condition: false
has only substance units: false
notes: FORMULA: C5H7O3 CHARGE: -1 INCHI: InChI=1S/C5H8O3/c1-3(2)4(6)5(7)8/h3H,1-2H3,(H,7,8)/p-1
type: Species
is: HMDB00019

metaM dhf e
initial concentration: 1.0
is: CHEBI:57451
is: SBO:0000247
initial amount: NaN
boundary condition: false
notes: FORMULA: C19H19N7O6 CHARGE: -2 INCHI: InChI=1S/C19H21N7O6/c20-19-25-15-14(17(30)26-19)23-11(8-22-15)7-21-10-3-1-9(2-4-10)16(29)24-12(18(31)32)5-6-13(27)28/h1-4,12,21H,5-8H2,(H,24,29)(H,27,28)(H,31,32)(H4,20,22,25,26,30)/p-2/t12-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00340 EHMN_ABBREVIATION: C00415
type: Species
has only substance units: false
constant: false
is: HMDB01056
name: dihydrofolate(2-)

metaR r1608
reactant: MODEL1310110063#
reversible: true
type: Reaction
kinetic law: MODEL1310110063#
fast: false
is described by: ECO:0000000
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
product: MODEL1310110063#

metaR AKR1D2
name: aldo-keto reductase family 1, member D1 (delta 4-3-ketosteroid-5-beta-reductase)
reactant: MODEL1310110063#
is: SBO:0000176
notes: GENE_ASSOCIATION: (6718.1) SUBSYSTEM: Bile acid synthesis EC Number: 1.3.99.6 Confidence Level: 4 AUTHORS: NOTES:refs: uniprot, KEGG DW Russell bile acid synthesis review paper (see human recon journal citations) NJ
is version of: http://identifiers.org/ec-code/1.3.1.3
modifier: MODEL1310110063#
is described by: ECO:0000269
kinetic law: MODEL1310110063#
reversible: false
fast: false
type: Reaction
product: MODEL1310110063#

metaR r2193
type: Reaction
is: SBO:0000185
modifier: MODEL1310110063#
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.14
notes: GENE_ASSOCIATION: (6566.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
kinetic law: MODEL1310110063#
reactant: MODEL1310110063#
reversible: true
product: MODEL1310110063#
is described by: ECO:0000000
fast: false

metaM HC00319 m
initial amount: NaN
name: Malonate
type: Species
initial concentration: 1.0
notes: FORMULA: C3H2O4 CHARGE: -2 INCHI: InChI=1S/C3H4O4/c4-2(5)1-3(6)7/h1H2,(H,4,5)(H,6,7)
is: CHEBI:30794
is: SBO:0000247
has only substance units: false
boundary condition: false
constant: false

http://identifiers.org/biomodels.db/MODEL1310110063#_3fec5d00_056a_4322_91c8_d5ed6fb5c24f
has only substance units: false
boundary condition: true
is: O00757
constant: false
initial amount: NaN
initial concentration: NaN
is: SBO:0000252
type: Species
name: FBP2
is encoded by: hsa:8789

http://identifiers.org/biomodels.db/MODEL1310110063#_e3cd779d_ee20_4869_ba13_10bc1755415b
constant: false
is: E9PCI1
is: SBO:0000252
has only substance units: false
boundary condition: true
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:53
type: Species
name: ACP2

metaR r0899
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:10721894,PMID:11787643,PMID:12269802,PMID:12504794,PMID:16955229,PMID:17401668,PMID:18599538,PMID:3132542,PMID:487087,PMID:551321,PMID:6418146,PMID:7731061,PMID:8010975,PMID:8382624,PMID:8654117,PMID:8899554,PMID:911815,PMID:917262 NOTES:
reversible: true
type: Reaction
is: SBO:0000185
name: Amino acid transporter ATB0+ Facilitated diffusion
fast: false
kinetic law: MODEL1310110063#
is described by: ECO:0000000
reactant: MODEL1310110063#
product: MODEL1310110063#

metaR FAOXC163C143m
kinetic law: MODEL1310110063#
product: MODEL1310110063#
reactant: MODEL1310110063#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C16:3-->C14:3)m
type: Reaction

metaM 3hddcoa m
name: (S)-3-Hydroxydodecanoyl-CoA
initial amount: NaN
initial concentration: 1.0
is: HMDB11123
boundary condition: false
has only substance units: false
is: C05279
is: SBO:0000247
type: Species
constant: false
notes: FORMULA: C33H54N7O18P3S CHARGE: -4

metaR EX tettet6 LPAREN e RPAREN
kinetic law: MODEL1310110063#
reactant: MODEL1310110063#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: tetracosatetraenoic acid n-6 exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110063#_33cf2d1d_5f94_4c1e_b123_3bbc8ada2bb5
is: SBO:0000252
type: Species
initial amount: NaN
is: Q16134
boundary condition: true
name: ETFDH
has only substance units: false
is encoded by: hsa:2110
initial concentration: NaN
constant: false

http://identifiers.org/biomodels.db/MODEL1310110063#_7e1f0b86_0c63_4e4d_9ac3_9a4765c4c384
type: Species
initial amount: NaN
is: SBO:0000252
has only substance units: false
is: Q96QE2
boundary condition: true
is encoded by: hsa:114134
name: SLC2A13
initial concentration: NaN
constant: false

http://identifiers.org/biomodels.db/MODEL1310110063#_f42e6dcd_d273_4ffa_9fe4_39812e354618
constant: false
initial concentration: NaN
name: ZADH2
initial amount: NaN
is encoded by: hsa:284273
has only substance units: false
is: Q8N4Q0
is: SBO:0000252
type: Species
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110063#_69947d7a_3a76_4a84_b463_ddbd24b2f291
initial concentration: NaN
boundary condition: true
type: Species
is: SBO:0000252
has only substance units: false
is encoded by: hsa:4047
name: LSS
initial amount: NaN
is: E9PEI9
constant: false

metaM fol c
notes: FORMULA: C19H18N7O6 CHARGE: -1
initial amount: NaN
is: HMDB00121
has only substance units: false
initial concentration: 1.0
is: SBO:0000247
constant: false
boundary condition: false
name: Folate
type: Species

http://identifiers.org/biomodels.db/MODEL1310110063#_9e6fe6c2_7a9b_4629_b10e_1e295953087c
boundary condition: true
constant: false
name: SLCO2A1
is: SBO:0000252
has only substance units: false
type: Species
is encoded by: hsa:6578
initial amount: NaN
is: Q92959
initial concentration: NaN

metaM hco3 c
initial concentration: 1.0
is: CHEBI:17544
is: C00288
initial amount: NaN
constant: false
type: Species
has only substance units: false
boundary condition: false
notes: FORMULA: CHO3 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00253 EHMN_ABBREVIATION: C00288
name: Bicarbonate
is: SBO:0000247
is: HMDB00595

metaR GLUt2m
type: Reaction
reversible: true
fast: false
is: SBO:0000185
kinetic law: MODEL1310110063#
notes: GENE_ASSOCIATION: (83733.1) or (8604.1) or (79751.1) or (10165.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172 NOTES:NCD
is described by: ECO:0000269
reactant: MODEL1310110063#
modifier: MODEL1310110063#
product: MODEL1310110063#
name: L-glutamate reversible transport via proton symport, mitochondrial

metaR r1607
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
kinetic law: MODEL1310110063#
fast: false
is: SBO:0000185
reversible: true
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
type: Reaction
product: MODEL1310110063#
reactant: MODEL1310110063#
is described by: ECO:0000000

metaM dhf c
is: HMDB01056
initial concentration: 1.0
initial amount: NaN
is: SBO:0000247
has only substance units: false
is: C00415
notes: FORMULA: C19H19N7O6 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00340 EHMN_ABBREVIATION: C00415
type: Species
is: CHEBI:57451
boundary condition: false
constant: false
name: 7,8-Dihydrofolate

metaM hpdcacoa m
initial concentration: 1.0
notes: FORMULA: C38H64N7O17P3S CHARGE: -4 INCHI: InChI=1/C38H68N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-29(47)66-22-21-40-28(46)19-20-41-36(50)33(49)38(2,3)24-59-65(56,57)62-64(54,55)58-23-27-32(61-63(51,52)53)31(48)37(60-27)45-26-44-30-34(39)42-25-43-35(30)45/h25-27,31-33,37,48-49H,4-24H2,1-3H3,(H,40,46)(H,41,50)(H,54,55)(H,56,57)(H2,39,42,43)(H2,51,52,53)/t27-,31-,32-,33+,37-/m1/s1
boundary condition: false
name: heptadecanoyl coa
type: Species
constant: false
is: HMDB06497
initial amount: NaN
has only substance units: false
is: SBO:0000247

metaR MTHFD
is: SBO:0000176
fast: false
reversible: true
name: methylenetetrahydrofolate dehydrogenase (NADP)
product: MODEL1310110063#
is version of: http://identifiers.org/ec-code/1.5.1.5
reactant: MODEL1310110063#
modifier: MODEL1310110063#
kinetic law: MODEL1310110063#
notes: GENE_ASSOCIATION: (4522.1) SUBSYSTEM: Folate metabolism EC Number: 1.5.1.5 Confidence Level: 4 AUTHORS: PMID:2786332 NOTES:Human Y/N: Y
type: Reaction
is described by: ECO:0000134

http://identifiers.org/biomodels.db/MODEL1310110063#_38f07ce3_666b_4bf6_a26d_9e1d39ed5e71
has only substance units: false
initial concentration: NaN
name: ATP1A3:ATP1B1
has part: B7Z2T0
initial amount: NaN
boundary condition: true
is: SBO:0000297
is encoded by: hsa:478
has part: A3KLL5
is encoded by: hsa:481
constant: false
type: Species

metaR DESAT22 2p
type: Reaction
reversible: false
is described by: ECO:0000000
name: fatty acyl-CoA desaturase (n-C22:5CoA -> n-C22:6CoA)
fast: false
kinetic law: MODEL1310110063#
is: SBO:0000176
reactant: MODEL1310110063#
product: MODEL1310110063#
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid synthesis EC Number: 1.14.19.1 Confidence Level: 4 AUTHORS: NOTES:

http://identifiers.org/biomodels.db/MODEL1310110063#_52827671_2a1d_49c8_994b_50c3c79be5ec
is: Q59EA4
initial amount: NaN
name: PLD1
type: Species
has only substance units: false
boundary condition: true
constant: false
initial concentration: NaN
is encoded by: hsa:5337
is: SBO:0000252

metaR FACOAL2252
product: MODEL1310110063#
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/6.2.1.3
modifier: MODEL1310110063#
kinetic law: MODEL1310110063#
notes: GENE_ASSOCIATION: (2180.1) SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 4 AUTHORS: PMID:15292367 NOTES:NJ
reactant: MODEL1310110063#
name: fatty-acid--CoA ligase
reversible: true
fast: false
is: SBO:0000176
type: Reaction

metaR r0679
notes: GENE_ASSOCIATION: (30.1) or (10449.1) or (3032.1) or (4645.1) SUBSYSTEM: CoA catabolism EC Number: 2.7.1.33 Confidence Level: 0 AUTHORS: PMID:10625688,PMID:13630913,PMID:15105273,PMID:15659606,PMID:16040613 NOTES:
name: ATP:pantothenate 4-phosphotransferase Pantothenate and CoA biosynthesis EC:2.7.1.33
is: SBO:0000176
fast: false
product: MODEL1310110063#
modifier: MODEL1310110063#
is version of: http://identifiers.org/ec-code/2.3.1.16
type: Reaction
is described by: ECO:0000000
reactant: MODEL1310110063#
kinetic law: MODEL1310110063#
reversible: true

metaM acac x
is: HMDB00060
initial amount: NaN
type: Species
has only substance units: false
name: acetoacetate
boundary condition: false
is: CHEBI:13705
notes: FORMULA: C4H5O3 CHARGE: -1 INCHI: InChI=1S/C4H6O3/c1-3(5)2-4(6)7/h2H2,1H3,(H,6,7)/p-1 HEPATONET_1.0_ABBREVIATION: HC00159 EHMN_ABBREVIATION: C00164
is: SBO:0000247
constant: false
initial concentration: 1.0

metaR r1606
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reactant: MODEL1310110063#
kinetic law: MODEL1310110063#
product: MODEL1310110063#
type: Reaction
reversible: true
is described by: ECO:0000000
is: SBO:0000185

metaR EX hco3 LPAREN e RPAREN
kinetic law: MODEL1310110063#
reactant: MODEL1310110063#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Bicarbonate exchange
type: Reaction

metaR r0340
kinetic law: MODEL1310110063#
fast: false
is version of: http://identifiers.org/ec-code/1.3.1.38
reversible: false
type: Reaction
name: ATP:(R)-glycerate 3-phosphotransferase Glycine, serine and threonine metabolism EC:2.7.1.31
modifier: MODEL1310110063#
product: MODEL1310110063#
is: SBO:0000176
notes: GENE_ASSOCIATION: (AA526438.1) or (H17063.1) or (51102.1) or (55825.1) SUBSYSTEM: Unassigned EC Number: 2.7.1.31 Confidence Level: 0 AUTHORS: PMID:16753811,PMID:216417,PMID:2537226,PMID:6252205 NOTES:
reactant: MODEL1310110063#
is described by: ECO:0000000

metaR SCP21x
reactant: MODEL1310110063#
is version of: http://identifiers.org/ec-code/2.3.1.176
kinetic law: MODEL1310110063#
fast: false
is: SBO:0000185
type: Reaction
modifier: MODEL1310110063#
product: MODEL1310110063#
reversible: true
name: Sterol carrier protein 2
notes: GENE_ASSOCIATION: (6342.1) SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 4 AUTHORS: PMID:1703300 NOTES:intracellular transport, mechanism details not presently known NJ
is described by: ECO:0000269

http://identifiers.org/biomodels.db/MODEL1310110063#_aece9f53_fe3b_4997_b143_cfbd75050531
is: Q9ULD0
initial concentration: NaN
name: OGDHL
has only substance units: false
boundary condition: true
type: Species
constant: false
initial amount: NaN
is encoded by: hsa:55753
is: SBO:0000252

metaR r2195
is: SBO:0000185
notes: GENE_ASSOCIATION: (6566.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
modifier: MODEL1310110063#
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.14
reactant: MODEL1310110063#
kinetic law: MODEL1310110063#
is described by: ECO:0000000
reversible: true
product: MODEL1310110063#
fast: false
type: Reaction

metaR NADtx
name: transport of NAD into peroxisome
fast: false
kinetic law: MODEL1310110063#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: NOTES:
type: Reaction
product: MODEL1310110063#
reversible: true
reactant: MODEL1310110063#
is described by: ECO:0000134

metaR MTHFC
product: MODEL1310110063#
type: Reaction
reactant: MODEL1310110063#
is: SBO:0000176
kinetic law: MODEL1310110063#
notes: GENE_ASSOCIATION: (4522.1) or (100287639.1) or (441024.1) SUBSYSTEM: Folate metabolism EC Number: 3.5.4.9 Confidence Level: 4 AUTHORS: PMID:2786332 NOTES:Human Y/N: Y
is version of: http://identifiers.org/ec-code/1.5.1.5
reversible: true
modifier: MODEL1310110063#
is version of: http://identifiers.org/ec-code/3.5.4.9
is described by: ECO:0000134
fast: false
name: methenyltetrahydrofolate cyclohydrolase

http://identifiers.org/biomodels.db/MODEL1310110063#_e140aa59_3352_442e_b03a_fa76668ce185
is encoded by: hsa:131669
is: Q68CJ7
initial amount: NaN
is: SBO:0000252
initial concentration: NaN
name: UROC1
has only substance units: false
boundary condition: true
constant: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110063#_5ce6d36c_6633_4b60_8f38_9a3415d2bb99
is encoded by: hsa:7915
is: Q546H9
initial concentration: NaN
boundary condition: true
has only substance units: false
initial amount: NaN
name: ALDH5A1
is: SBO:0000252
constant: false
type: Species

metaR FACOAL2251
is: SBO:0000176
type: Reaction
kinetic law: MODEL1310110063#
notes: GENE_ASSOCIATION: (2180.1) SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 4 AUTHORS: PMID:15292367 NOTES:NJ
reactant: MODEL1310110063#
name: fatty-acid--CoA ligase
fast: false
is version of: http://identifiers.org/ec-code/6.2.1.3
modifier: MODEL1310110063#
is described by: ECO:0000000
product: MODEL1310110063#
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110063#_eba0e284_812f_49ff_8542_4a876198805e
type: Species
is: SBO:0000252
boundary condition: true
constant: false
initial concentration: NaN
initial amount: NaN
name: GNS
is: Q7Z3X3
has only substance units: false
is encoded by: hsa:2799

metaM dhlam m
initial amount: NaN
has only substance units: false
constant: false
type: Species
is: CHEBI:17694
notes: FORMULA: C8H17NOS2 CHARGE: 0 INCHI: InChI=1S/C8H17NOS2/c9-8(10)4-2-1-3-7(12)5-6-11/h7,11-12H,1-6H2,(H2,9,10) HEPATONET_1.0_ABBREVIATION: HC00437 EHMN_ABBREVIATION: C00579
boundary condition: false
initial concentration: 1.0
is: SBO:0000247
name: dihydrolipoamide
is: HMDB00985

http://identifiers.org/biomodels.db/MODEL1310110063#_b67fd140_4c5f_423a_af28_bf97c6363ada
initial concentration: NaN
constant: false
is encoded by: hsa:2098
type: Species
has only substance units: false
is: P10768
name: ESD
is: SBO:0000252
initial amount: NaN
boundary condition: true

metaR EX nh4 LPAREN e RPAREN
kinetic law: MODEL1310110063#
reactant: MODEL1310110063#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Ammonia exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110063#_7204f8cf_d6d7_437d_8b82_8f6c859cc107
type: Species
initial amount: NaN
is encoded by: hsa:501
constant: false
name: ALDH7A1
is: E7EPT3
boundary condition: true
has only substance units: false
is: SBO:0000252
initial concentration: NaN

metaR EX fmn LPAREN e RPAREN
kinetic law: MODEL1310110063#
reactant: MODEL1310110063#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for FMN
type: Reaction

metaM hco3 e
initial concentration: 1.0
is: CHEBI:17544
initial amount: NaN
is: C00288
constant: false
type: Species
is: SBO:0000247
has only substance units: false
boundary condition: false
notes: FORMULA: CHO3 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00253 EHMN_ABBREVIATION: C00288
is: HMDB00595
name: Bicarbonate

metaR r1605
kinetic law: MODEL1310110063#
product: MODEL1310110063#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is: SBO:0000185
type: Reaction
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
fast: false
reversible: true
reactant: MODEL1310110063#

metaM leuleu c
name: Leucylleucine
notes: FORMULA: C12H24N2O3 CHARGE: 0
initial amount: NaN
is: http://identifiers.org/pubchem.compound/94244
boundary condition: false
constant: false
initial concentration: 1.0
type: Species
is: SBO:0000247
has only substance units: false

metaR r2194
reversible: true
type: Reaction
reactant: MODEL1310110063#
kinetic law: MODEL1310110063#
product: MODEL1310110063#
fast: false
notes: GENE_ASSOCIATION: (6566.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
modifier: MODEL1310110063#
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.14
is: SBO:0000185
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110063#_ed502b0c_0980_453a_8d8d_2605a16109d5
is encoded by: hsa:60386
is: SBO:0000252
name: SLC25A19
is: Q9HC21
boundary condition: true
constant: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
type: Species

metaR AMPtp
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 0 AUTHORS: NOTES:"diffusion" NJ
is: SBO:0000185
product: MODEL1310110063#
is described by: ECO:0000000
kinetic law: MODEL1310110063#
reversible: true
reactant: MODEL1310110063#
type: Reaction
fast: false
name: AMP transporter, peroxisome

metaM cs b deg1 l
initial amount: NaN
boundary condition: false
is: HMDB01354
notes: FORMULA: C45H67N2O46S3 CHARGE: -5
is: CHEBI:57455
initial concentration: 1.0
constant: false
type: Species
has only substance units: false
name: chondroitin sulfate B / dermatan sulfate (IdoA2S-GalNAc4S), degradation product 1
is: SBO:0000247

metaM hedepecoa m
has only substance units: false
is: HMDB02288
boundary condition: false
notes: FORMULA: C37H52N7O17P3S CHARGE: -4
name: 2,4,7,10,13-hexadecapentenoylcoa
initial concentration: 1.0
initial amount: NaN
is: SBO:0000247
constant: false
type: Species

metaR SO4CLtex2
is: SBO:0000185
type: Reaction
kinetic law: MODEL1310110063#
is described by: ECO:0000304
name: sulfate transport via chloride countertransport (2:1)
fast: false
reactant: MODEL1310110063#
reversible: false
notes: GENE_ASSOCIATION: (65010.1) or (65010.3) or (65010.2) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:12759755 NOTES:SAB
product: MODEL1310110063#
modifier: MODEL1310110063#

http://identifiers.org/biomodels.db/MODEL1310110063#_38ba61c2_d92e_44e8_8012_b55bd5b25317
constant: false
initial amount: NaN
has only substance units: false
is: SBO:0000252
is encoded by: hsa:2348
type: Species
boundary condition: true
initial concentration: NaN
name: FOLR1

metaR SERLYSNaex
reversible: false
is described by: ECO:0000212
notes: GENE_ASSOCIATION: (9056.1 and 6519.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 1 AUTHORS: PMID:14770310 NOTES:SAB see PMID 14770310
fast: false
reactant: MODEL1310110063#
is: SBO:0000185
type: Reaction
modifier: MODEL1310110063#
product: MODEL1310110063#
kinetic law: MODEL1310110063#
name: Serine/Lysine Na-dependent exchange (Ser in)

metaR RE2999M
modifier: MODEL1310110063#
is described by: ECO:0000000
type: Reaction
reversible: true
reactant: MODEL1310110063#
name: RE2999
is: SBO:0000176
fast: false
kinetic law: MODEL1310110063#
notes: GENE_ASSOCIATION: (1632.1) or (10455.1) or (1962.1) SUBSYSTEM: Fatty acid oxidation EC Number: 5.3.3.8 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:7775433 NOTES:
is version of: http://identifiers.org/ec-code/5.3.3.8
is version of: http://identifiers.org/ec-code/1.1.1.35
product: MODEL1310110063#

metaR EX cys L LPAREN e RPAREN
kinetic law: MODEL1310110063#
reactant: MODEL1310110063#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for L-cysteine
type: Reaction

metaR EX Rtotal3 LPAREN e RPAREN
kinetic law: MODEL1310110063#
reactant: MODEL1310110063#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: R total 3 position exchange
type: Reaction

metaR EX cit LPAREN e RPAREN
kinetic law: MODEL1310110063#
reactant: MODEL1310110063#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Citrate exchange
type: Reaction

metaR ILEtec
product: MODEL1310110063#
is: SBO:0000185
notes: GENE_ASSOCIATION: (8501.1) or (124935.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12930836,PMID:14624363,PMID:15659399 NOTES:SAB
reactant: MODEL1310110063#
kinetic law: MODEL1310110063#
is described by: ECO:0000269
name: L-isoleucine transport via diffusion (extracellular to cytosol)
reversible: true
type: Reaction
fast: false
modifier: MODEL1310110063#

metaM dtdp e
notes: FORMULA: C10H13N2O11P2 CHARGE: -3 INCHI: InChI=1S/C10H16N2O11P2/c1-5-3-12(10(15)11-9(5)14)8-2-6(13)7(22-8)4-21-25(19,20)23-24(16,17)18/h3,6-8,13H,2,4H2,1H3,(H,19,20)(H,11,14,15)(H2,16,17,18)/p-3/t6-,7+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00307 EHMN_ABBREVIATION: C00363
type: Species
constant: false
boundary condition: false
is: SBO:0000247
initial amount: NaN
initial concentration: 1.0
has only substance units: false
is: CHEBI:58369
is: HMDB01274
name: ({[(2R,3S,5R)-3-hydroxy-5-(5-methyl-2,4-dioxo-1,2,3,4-tetrahydropyrimidin-1-yl)oxolan-2-yl]methyl phosphonato}oxy)phosphonate

metaR ARACHCRNt
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (788.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: NOTES:NJ
name: transport into the mitochondria (carnitine)
fast: false
type: Reaction
reactant: MODEL1310110063#
product: MODEL1310110063#
kinetic law: MODEL1310110063#
modifier: MODEL1310110063#
reversible: false
is: SBO:0000185

metaR IDOAASE1ly
kinetic law: MODEL1310110063#
fast: false
type: Reaction
is: SBO:0000176
name: alpha-L-iduronidase, lysosomal
modifier: MODEL1310110063#
is version of: http://identifiers.org/ec-code/3.2.1.76
is described by: ECO:0000000
product: MODEL1310110063#
reactant: MODEL1310110063#
reversible: false
notes: GENE_ASSOCIATION: (3425.1) SUBSYSTEM: Heparan sulfate degradation EC Number: 3.2.1.76 Confidence Level: 4 AUTHORS: PMID:1946389,PMID:2470345 NOTES:NCD

http://identifiers.org/biomodels.db/MODEL1310110063#_6d16a215_b86b_4633_8cb7_8e4454bb368f
type: Species
initial amount: NaN
is encoded by: hsa:27068
is: SBO:0000252
is: F8WDN9
constant: false
boundary condition: true
name: PPA2
initial concentration: NaN
has only substance units: false

metaR r2197
type: Reaction
notes: GENE_ASSOCIATION: (6566.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
fast: false
reversible: true
kinetic law: MODEL1310110063#
reactant: MODEL1310110063#
product: MODEL1310110063#
is described by: ECO:0000000
modifier: MODEL1310110063#
is: SBO:0000185
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.14

metaR r2039
reactant: MODEL1310110063#
is: SBO:0000185
modifier: MODEL1310110063#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.15
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
type: Reaction
product: MODEL1310110063#
reversible: false
kinetic law: MODEL1310110063#
is described by: ECO:0000000
fast: false

metaR r0456
reactant: MODEL1310110063#
name: ATP:deoxyguanosine 5-phosphotransferase Purine metabolism EC:2.7.1.113
notes: GENE_ASSOCIATION: (AA614647.1) or (1120.1) or (1374.1) or (1375.1) or (126129.1) or (1376.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.1.113 Confidence Level: 0 AUTHORS: PMID:15748706 NOTES:
is: SBO:0000176
reversible: false
kinetic law: MODEL1310110063#
is described by: ECO:0000000
product: MODEL1310110063#
is version of: http://identifiers.org/ec-code/2.3.1.21
modifier: MODEL1310110063#
is version of: http://identifiers.org/ec-code/2.7.1.32
type: Reaction
fast: false

http://identifiers.org/biomodels.db/MODEL1310110063#_163d4b4e_6aca_466c_bf53_74916d24aa57
has only substance units: false
initial amount: NaN
constant: false
is: SBO:0000252
type: Species
is encoded by: hsa:BC005314
name: _BC005314_1_x
boundary condition: true
initial concentration: NaN

metaR FACOAL161
name: fatty-acid--CoA ligase (hexadecenoate)
kinetic law: MODEL1310110063#
is: SBO:0000176
type: Reaction
is version of: http://identifiers.org/ec-code/6.2.1.3
reversible: true
modifier: MODEL1310110063#
product: MODEL1310110063#
notes: GENE_ASSOCIATION: (2180.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: NOTES:
reactant: MODEL1310110063#
fast: false
is described by: ECO:0000000

metaR PIPLC
modifier: MODEL1310110063#
kinetic law: MODEL1310110063#
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/3.1.4.11
reactant: MODEL1310110063#
notes: GENE_ASSOCIATION: (23236.2) or (5336.1) or (23007.1) or (113026.1) or (89869.1) or (84812.1) or (9651.1) or (5335.1) or (51196.1) or (257068.1) or (5332.2) or (5331.1) or (5335.2) or (5334.1) or (5332.1) or (5330.1) or (23236.1) or (5333.1) SUBSYSTEM: Inositol phosphate metabolism EC Number: 3.1.4.3 Confidence Level: 4 AUTHORS: PMID:10702670,PMID:10702683,PMID:10760467,PMID:11022047,PMID:11022048,PMID:11118617,PMID:12117804,PMID:12213492,PMID:12416999,PMID:13333955,PMID:15140260,PMID:1644792,PMID:2167438,PMID:7607669,PMID:7612006,PMID:7633416,PMID:7789993,PMID:7835906,PMID:7849701,PMID:7890667,PMID:8530101,PMID:9345909 NOTES:NCD
product: MODEL1310110063#
reversible: false
type: Reaction
name: phosphatidylinositol phospholipase C
is: SBO:0000176
fast: false

metaR r2196
is described by: ECO:0000000
fast: false
modifier: MODEL1310110063#
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.14
kinetic law: MODEL1310110063#
type: Reaction
reactant: MODEL1310110063#
notes: GENE_ASSOCIATION: (6566.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
product: MODEL1310110063#
is: SBO:0000185
reversible: true

metaM nrpphrsf e
constant: false
initial amount: NaN
has only substance units: false
boundary condition: false
is: HMDB02062
is: SBO:0000247
is: http://identifiers.org/pubchem.compound/123747
notes: FORMULA: C8H11NO6S CHARGE: 0 INCHI: InChI=1/C8H11NO6S/c9-4-7(11)5-1-2-8(6(10)3-5)15-16(12,13)14/h1-3,7,10-11H,4,9H2,(H,12,13,14)/t7-/m0/s1
initial concentration: 1.0
type: Species
name: Sulfate derivative of norepinephrine

metaR BDHm
is: SBO:0000176
kinetic law: MODEL1310110063#
reversible: true
type: Reaction
fast: false
reactant: MODEL1310110063#
name: (R)-3-Hydroxybutanoate:NAD+ oxidoreductase
notes: GENE_ASSOCIATION: (622.2) or (622.3) or (622.1) SUBSYSTEM: Butanoate metabolism EC Number: 1.1.1.30 Confidence Level: 4 AUTHORS: PMID:1639787,PMID:8679568 NOTES:IT
is version of: http://identifiers.org/ec-code/1.1.1.30
product: MODEL1310110063#
is described by: ECO:0000269
modifier: MODEL1310110063#

metaR DOLGLCP Uter
notes: GENE_ASSOCIATION: SUBSYSTEM: N-glycan synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:12137737 NOTES:
is: SBO:0000185
kinetic law: MODEL1310110063#
fast: false
reversible: false
product: MODEL1310110063#
reactant: MODEL1310110063#
is described by: ECO:0000000
name: Dolichyl beta-D-glucosyl phosphate flippase (uterus)
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110063#_1884ffb2_a4a7_4a27_9842_5a54c97eb2ab
boundary condition: true
is encoded by: hsa:30814
constant: false
initial amount: NaN
type: Species
name: PLA2G2E
is: SBO:0000252
has only substance units: false
initial concentration: NaN
is: Q9NZK7

http://identifiers.org/biomodels.db/MODEL1310110063#_bc963c34_b586_43dc_93a6_f7675341c6bf
is encoded by: hsa:6528
initial amount: NaN
boundary condition: true
name: SLC5A5
constant: false
is: SBO:0000252
type: Species
is: Q92911
initial concentration: NaN
has only substance units: false

metaR ASNSERNaEx
is: SBO:0000185
is described by: ECO:0000269
fast: false
product: MODEL1310110063#
type: Reaction
name: L-serine/L-asparagine Na-dependent exchange (Asn-L in)
modifier: MODEL1310110063#
kinetic law: MODEL1310110063#
notes: GENE_ASSOCIATION: (6510.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14530974 NOTES:SAB see Kanai and Hediger 2004 (2003), PMID 14530974
reactant: MODEL1310110063#
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110063#_dd38af26_1d47_4f9a_a704_ac1a21b08464
is: A8K3J4
initial concentration: NaN
constant: false
is: SBO:0000252
type: Species
is encoded by: hsa:23632
name: CA14
initial amount: NaN
has only substance units: false
boundary condition: true

metaR FRDPtcr
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: required for cholesterol synthesis in E.R. NOTES:required for cholesterol synthesis in E.R.
reversible: true
is: SBO:0000185
is described by: ECO:0000134
fast: false
name: transport of Farnesyl diphosphate into the endoplasmic reticulum
kinetic law: MODEL1310110063#
product: MODEL1310110063#
reactant: MODEL1310110063#

http://identifiers.org/biomodels.db/MODEL1310110063#_8d0fdd2d_23f7_43ec_9f93_0f82a20c0538
constant: false
initial concentration: NaN
is: Q16222
initial amount: NaN
is encoded by: hsa:6675
is: SBO:0000252
has only substance units: false
boundary condition: true
name: UAP1
type: Species

metaM ksii core4 pre8 g
constant: false
initial concentration: 1.0
notes: FORMULA: C83H134N7O61SX CHARGE: -2
type: Species
boundary condition: false
has only substance units: false
name: keratan sulfate II biosynthesis, precursor 8
is: SBO:0000247
is: HMDB00175
initial amount: NaN
is: C00130
is: CHEBI:58053

metaM mercplaccys e
boundary condition: false
notes: FORMULA: C6H10O5S2N CHARGE: -1 INCHI: InChI=1/C6H11NO5S2/c7-3(5(9)10)1-13-14-2-4(8)6(11)12/h3-4,8H,1-2,7H2,(H,9,10)(H,11,12)/t3-,4?/m0/s1
initial concentration: 1.0
has only substance units: false
is: HMDB06512
is: SBO:0000247
initial amount: NaN
constant: false
name: 3-mercaptolactate-cysteine disulfide
type: Species

metaM xtsn c
boundary condition: false
is: CHEBI:18107
type: Species
has only substance units: false
initial concentration: 1.0
notes: FORMULA: C10H12N4O6 CHARGE: 0 INCHI: InChI=1S/C10H12N4O6/c15-1-3-5(16)6(17)9(20-3)14-2-11-4-7(14)12-10(19)13-8(4)18/h2-3,5-6,9,15-17H,1H2,(H2,12,13,18,19)/t3-,5-,6-,9-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00838 EHMN_ABBREVIATION: C01762
initial amount: NaN
is: HMDB00299
constant: false
is: SBO:0000247
name: xanthosine

http://identifiers.org/biomodels.db/MODEL1310110063#_ac368e1b_2121_4f62_ae7c_c9bad0f38a7b
boundary condition: true
initial amount: NaN
type: Species
name: NT5C1B
initial concentration: NaN
is: Q96P26
is encoded by: hsa:93034
constant: false
has only substance units: false
is: SBO:0000252

metaM 4izp c
type: Species
is: CHEBI:57255
notes: FORMULA: C6H7N2O3 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC01157 EHMN_ABBREVIATION: C03680
is: HMDB01014
initial amount: NaN
constant: false
boundary condition: false
is: SBO:0000247
has only substance units: false
name: 4-Imidazolone-5-propanoate
initial concentration: 1.0

metaM dtdp c
notes: FORMULA: C10H13N2O11P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00307 EHMN_ABBREVIATION: C00363
type: Species
is: C00363
boundary condition: false
has only substance units: false
initial concentration: 1.0
constant: false
is: SBO:0000247
initial amount: NaN
is: CHEBI:58369
name: dTDP
is: HMDB01274

metaR TPI
fast: false
is described by: ECO:0000134
reversible: true
type: Reaction
kinetic law: MODEL1310110063#
reactant: MODEL1310110063#
is: SBO:0000176
product: MODEL1310110063#
notes: GENE_ASSOCIATION: (7167.1) or (286016.1) SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: 5.3.1.1 Confidence Level: 0 AUTHORS: PMID:18456264,PMID:18840520,PMID:2579079,PMID:999837 NOTES:SMP. 18840520 - expression data; 18456264 - protein purification; 2579079 - genetic, homology; 999837 - biochemical
name: triose-phosphate isomerase
modifier: MODEL1310110063#
is version of: http://identifiers.org/ec-code/5.3.1.1

metaM eitetcoa m
initial concentration: 1.0
name: 5,8,11,14-eicosatetraenoylcoa
is: http://identifiers.org/pubchem.compound/24892790
constant: false
has only substance units: false
is: SBO:0000247
type: Species
initial amount: NaN
boundary condition: false
notes: FORMULA: C41H62N7O17P3S CHARGE: -4

metaR PETHCT
kinetic law: MODEL1310110063#
name: phosphoethanolamine cytidyltransferase
type: Reaction
notes: GENE_ASSOCIATION: (5833.1) SUBSYSTEM: Glycerophospholipid metabolism EC Number: 2.7.7.14 Confidence Level: 4 AUTHORS: NOTES:NCD
fast: false
reversible: false
is: SBO:0000176
reactant: MODEL1310110063#
is version of: http://identifiers.org/ec-code/2.7.7.14
product: MODEL1310110063#
is described by: ECO:0000269
modifier: MODEL1310110063#

metaR FAOXC61m
kinetic law: MODEL1310110063#
product: MODEL1310110063#
reactant: MODEL1310110063#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: isomerization(C6:1)m
type: Reaction

metaM dhea c
type: Species
constant: false
boundary condition: false
is: HMDB00077
notes: FORMULA: C19H28O2 CHARGE: 0 INCHI: InChI=1S/C19H28O2/c1-18-9-7-13(20)11-12(18)3-4-14-15-5-6-17(21)19(15,2)10-8-16(14)18/h3,13-16,20H,4-11H2,1-2H3/t13-,14-,15-,16-,18-,19-/m0/s1 EHMN_ABBREVIATION: C01227
name: 3beta-hydroxyandrost-5-en-17-one
initial concentration: 1.0
has only substance units: false
is: CHEBI:28689
initial amount: NaN
is: SBO:0000247

metaR r2199
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.5
notes: GENE_ASSOCIATION: (6566.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
modifier: MODEL1310110063#
fast: false
reactant: MODEL1310110063#
reversible: true
is described by: ECO:0000000
kinetic law: MODEL1310110063#
product: MODEL1310110063#
is: SBO:0000185
type: Reaction

metaR S2TASE1ly
modifier: MODEL1310110063#
name: iduronate-2-sulfatase, lysosomal
is: SBO:0000176
reactant: MODEL1310110063#
reversible: false
fast: false
is described by: ECO:0000000
kinetic law: MODEL1310110063#
type: Reaction
is version of: http://identifiers.org/ec-code/3.1.6.13
product: MODEL1310110063#
notes: GENE_ASSOCIATION: (3423.1) or (3423.2) SUBSYSTEM: Heparan sulfate degradation EC Number: 3.1.6.13 Confidence Level: 4 AUTHORS: PMID:2122463,PMID:8244397,PMID:8530090,PMID:8993162 NOTES:NCD

metaR 4HGLSDm
is: SBO:0000176
kinetic law: MODEL1310110063#
reversible: true
reactant: MODEL1310110063#
product: MODEL1310110063#
modifier: MODEL1310110063#
is version of: http://identifiers.org/ec-code/1.5.1.12
fast: false
is described by: ECO:0000212
notes: GENE_ASSOCIATION: (8659.1) or (8659.2) SUBSYSTEM: Arginine and Proline Metabolism EC Number: 1.5.1.12 Confidence Level: 1 AUTHORS: PMID:15849464 NOTES:NCD
type: Reaction
name: L-4-hydroxyglutamate semialdehyde dehydrogenase, mitochondrial

metaM ala B m
is: CHEBI:16958
initial concentration: 1.0
is: SBO:0000247
initial amount: NaN
constant: false
boundary condition: false
name: beta-alanine
type: Species
notes: FORMULA: C3H7NO2 CHARGE: 0 INCHI: InChI=1S/C3H7NO2/c4-2-1-3(5)6/h1-2,4H2,(H,5,6) HEPATONET_1.0_ABBREVIATION: HC00100
is: HMDB00056
has only substance units: false

metaR r1609
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
kinetic law: MODEL1310110063#
fast: false
is: SBO:0000185
reversible: true
type: Reaction
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reactant: MODEL1310110063#
product: MODEL1310110063#

metaM ksi deg39 l
initial concentration: 1.0
boundary condition: false
is: CHEBI:12936
is: SBO:0000247
constant: false
type: Species
is: HMDB00143
notes: FORMULA: C48H81N3O36 CHARGE: 0
name: keratan sulfate I, degradation product 39
has only substance units: false
initial amount: NaN

metaM fol e
is: HMDB00121
constant: false
has only substance units: false
is: SBO:0000247
notes: FORMULA: C19H18N7O6 CHARGE: -1
name: Folate
initial concentration: 1.0
type: Species
boundary condition: false
initial amount: NaN

metaR TDCHOLAte
product: MODEL1310110063#
is: SBO:0000185
is described by: ECO:0000000
kinetic law: MODEL1310110063#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:unknown mechanism, however bile acids need to be secreted out of the cell NJ
name: bile acid intracellular transport
fast: false
reactant: MODEL1310110063#
reversible: true
type: Reaction

metaR CHOLtu
name: Choline uniport
fast: false
product: MODEL1310110063#
notes: GENE_ASSOCIATION: (6582.1) or (6584.1) or (6582.2) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12883891 NOTES:SAB electrogenic, Na indepdendent & rev
reversible: true
reactant: MODEL1310110063#
kinetic law: MODEL1310110063#
type: Reaction
modifier: MODEL1310110063#
is: SBO:0000185
is described by: ECO:0000269

metaR NP1
product: MODEL1310110063#
is version of: http://identifiers.org/ec-code/2.4.2.1
modifier: MODEL1310110063#
notes: GENE_ASSOCIATION: (4860.1) SUBSYSTEM: NAD metabolism EC Number: 3.4.2.1 Confidence Level: 2 AUTHORS: NOTES:NCD
type: Reaction
kinetic law: MODEL1310110063#
fast: false
is described by: ECO:0000304
is: SBO:0000176
reactant: MODEL1310110063#
reversible: false
name: nucleotide phosphatase

metaR PUNP7
is: SBO:0000176
reactant: MODEL1310110063#
product: MODEL1310110063#
kinetic law: MODEL1310110063#
is described by: ECO:0000269
modifier: MODEL1310110063#
is version of: http://identifiers.org/ec-code/2.4.2.1
fast: false
name: purine-nucleoside phosphorylase (Xanthosine)
notes: GENE_ASSOCIATION: (4860.1) SUBSYSTEM: Nucleotide interconversion EC Number: 3.4.2.1 Confidence Level: 4 AUTHORS: PMID:6087295,PMID:9305963 NOTES:Specificity not completely determined. Can also catalyse ribosyltransferase reactions of the type catalysed by EC 2.4.2.5, nucleoside ribosyltransferasextsn
reversible: true
type: Reaction

metaR C140CPT1
kinetic law: MODEL1310110063#
product: MODEL1310110063#
reactant: MODEL1310110063#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: production of myristoylcarnitine
type: Reaction

metaM tyr L m
type: Species
has only substance units: false
constant: false
is: HMDB00158
is: SBO:0000247
name: L-tyrosine
initial concentration: 1.0
initial amount: NaN
boundary condition: false
notes: FORMULA: C9H11NO3 CHARGE: 0 INCHI: InChI=1S/C9H11NO3/c10-8(9(12)13)5-6-1-3-7(11)4-2-6/h1-4,8,11H,5,10H2,(H,12,13)/t8-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00085
is: CHEBI:17895

metaR H2O2t
reactant: MODEL1310110063#
fast: false
name: hydrogen peroxide transport via diffusion
product: MODEL1310110063#
kinetic law: MODEL1310110063#
is: SBO:0000185
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:2989289 NOTES:AMF
type: Reaction
reversible: true

metaR r2198
reactant: MODEL1310110063#
type: Reaction
notes: GENE_ASSOCIATION: (6566.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
modifier: MODEL1310110063#
kinetic law: MODEL1310110063#
product: MODEL1310110063#
is: SBO:0000185
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.5
reversible: true
is described by: ECO:0000000
fast: false

metaR CYSASNNaEx
name: L-cysteine/L-asparagine Na-dependent exchange (Cys-L in)
is described by: ECO:0000269
modifier: MODEL1310110063#
type: Reaction
reactant: MODEL1310110063#
product: MODEL1310110063#
fast: false
reversible: false
is: SBO:0000185
notes: GENE_ASSOCIATION: (6510.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14530974 NOTES:SAB see Kanai and Hediger 2004 (2003), PMID 14530974
kinetic law: MODEL1310110063#

metaM nrpphrsf c
is: SBO:0000247
name: Sulfate derivative of norepinephrine
is: http://identifiers.org/pubchem.compound/123747
initial amount: NaN
type: Species
is: HMDB02062
has only substance units: false
boundary condition: false
initial concentration: 1.0
constant: false
notes: FORMULA: C8H11NO6S CHARGE: 0 INCHI: InChI=1/C8H11NO6S/c9-4-7(11)5-1-2-8(6(10)3-5)15-16(12,13)14/h1-3,7,10-11H,4,9H2,(H,12,13,14)/t7-/m0/s1

http://identifiers.org/biomodels.db/MODEL1310110063#_f6fb5beb_24a8_4c14_8b31_1b9970cbf3c4
initial concentration: NaN
has only substance units: false
name: ECI2
constant: false
boundary condition: true
is encoded by: hsa:10455
type: Species
is: O75521
is: SBO:0000252
initial amount: NaN

metaM 3mob m
is: SBO:0000247
is: HMDB00019
initial concentration: 1.0
name: 3-methyl-2-oxobutanoate
has only substance units: false
initial amount: NaN
type: Species
is: CHEBI:11851
boundary condition: false
constant: false
notes: FORMULA: C5H7O3 CHARGE: -1 INCHI: InChI=1S/C5H8O3/c1-3(2)4(6)5(7)8/h3H,1-2H3,(H,7,8)/p-1 HEPATONET_1.0_ABBREVIATION: HC00139 EHMN_ABBREVIATION: C00141

http://identifiers.org/biomodels.db/MODEL1310110063#_2a9703d9_8ba2_4d53_9440_a64445da10e9
is encoded by: hsa:54995
type: Species
boundary condition: true
is: SBO:0000252
initial amount: NaN
has only substance units: false
constant: false
name: OXSM
is: Q9NWU1
initial concentration: NaN

metaM gacpail hs c
is: C00092
constant: false
type: Species
is: CHEBI:61548
is: HMDB01401
name: glucosaminyl-acylphosphatidylinositol
boundary condition: false
notes: FORMULA: C31H58NO14PFULLRCO2FULLR2CO2 CHARGE: 0
initial amount: NaN
initial concentration: 1.0
has only substance units: false
is: SBO:0000247

metaM Lcystin c
is: SBO:0000247
initial amount: NaN
boundary condition: false
notes: FORMULA: C6H12N2O4S2 CHARGE: 0 INCHI: InChI=1S/C6H12N2O4S2/c7-3(5(9)10)1-13-14-2-4(8)6(11)12/h3-4H,1-2,7-8H2,(H,9,10)(H,11,12)/t3-,4-/m0/s1
name: L-cystine
type: Species
initial concentration: 1.0
has only substance units: false
is: HMDB00192
is: CHEBI:16283
constant: false

http://identifiers.org/biomodels.db/MODEL1310110063#_2ec4f3ec_f20a_4b26_b16d_a082a32ec38b
is: Q53F23
is encoded by: hsa:6916
type: Species
name: TBXAS1
constant: false
boundary condition: true
is: SBO:0000252
initial concentration: NaN
has only substance units: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110063#_76b8282f_d62c_40bf_85ac_5d5e7157a138
name: ACSL1
is encoded by: hsa:2180
initial concentration: NaN
initial amount: NaN
constant: false
has only substance units: false
is: SBO:0000252
is: P33121
boundary condition: true
type: Species

http://identifiers.org/biomodels.db/MODEL1310110063#_336ebab7_e105_4763_8c3a_cb050bacfd88
initial amount: NaN
is: SBO:0000252
boundary condition: true
is encoded by: hsa:H45672
type: Species
constant: false
has only substance units: false
name: _H45672_1_m
initial concentration: NaN

metaR OMHDEACIDTD
kinetic law: MODEL1310110063#
product: MODEL1310110063#
reactant: MODEL1310110063#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: transport of w-hydroxydecanoic acid by diffusion
type: Reaction

metaR r1600
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is: SBO:0000185
reactant: MODEL1310110063#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
type: Reaction
product: MODEL1310110063#
fast: false
kinetic law: MODEL1310110063#
is described by: ECO:0000000
reversible: true

metaR PUNP2
notes: GENE_ASSOCIATION: (4860.1) SUBSYSTEM: Purine catabolism EC Number: 3.4.2.1 Confidence Level: 4 AUTHORS: PMID:6087295,PMID:9305963 NOTES:Specificity not completely determined. Can also catalyse ribosyltransferase reactions of the type catalysed by EC 2.4.2.5, nucleoside ribosyltransferase
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.4.2.1
reactant: MODEL1310110063#
fast: false
is described by: ECO:0000269
name: purine-nucleoside phosphorylase (Deoxyadenosine)
reversible: true
kinetic law: MODEL1310110063#
modifier: MODEL1310110063#
type: Reaction
product: MODEL1310110063#

metaR LTC4Sr
is described by: ECO:0000269
name: Leukotriene C4 synthase
modifier: MODEL1310110063#
fast: false
reactant: MODEL1310110063#
product: MODEL1310110063#
is version of: http://identifiers.org/ec-code/4.4.1.20
is version of: http://identifiers.org/ec-code/2.5.1.18
kinetic law: MODEL1310110063#
is: SBO:0000176
reversible: false
notes: GENE_ASSOCIATION: (4056.1) or (4259.1) or (4056.2) or (4258.1) SUBSYSTEM: Eicosanoid metabolism EC Number: 4.4.1.20 Confidence Level: 4 AUTHORS: PMID:11160764 NOTES:previous EC 2.5.1.37 EC: 4.4.1.20 NJ
type: Reaction

metaR 34HPPte
fast: false
is described by: ECO:0000134
product: MODEL1310110063#
reversible: true
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
reactant: MODEL1310110063#
kinetic law: MODEL1310110063#
is: SBO:0000185
name: Transport of 3-(4-hydroxyphenyl)pyruvate

http://identifiers.org/biomodels.db/MODEL1310110063#_1a108780_e06e_431a_a4a0_2e9fe81702c6
type: Species
is: Q9UBM1
is encoded by: hsa:10400
has only substance units: false
name: PEMT
boundary condition: true
initial concentration: NaN
constant: false
initial amount: NaN
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110063#_ec1e7586_223e_418c_af00_e90113cd470c
name: SLC2A6
boundary condition: true
is encoded by: hsa:11182
has only substance units: false
initial concentration: NaN
initial amount: NaN
type: Species
is: Q9UGQ3
is: SBO:0000252
constant: false

metaM peamn c
is: SBO:0000247
initial amount: NaN
is: CHEBI:225237
constant: false
has only substance units: false
initial concentration: 1.0
name: 2-phenylethanaminium
is: HMDB12275
notes: FORMULA: C8H12N CHARGE: 1 INCHI: InChI=1S/C8H11N/c9-7-6-8-4-2-1-3-5-8/h1-5H,6-7,9H2/p+1 EHMN_ABBREVIATION: C05332
boundary condition: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110063#_74527cf0_a66f_43c5_88e5_44d22a7687a6
name: ITPKA
is: SBO:0000252
type: Species
constant: false
initial amount: NaN
is encoded by: hsa:3706
boundary condition: true
initial concentration: NaN
has only substance units: false
is: P23677

http://identifiers.org/biomodels.db/MODEL1310110063#_d66ded1f_4f22_4f1c_82d6_f3cf7ff023dc
boundary condition: true
constant: false
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:6487
initial amount: NaN
type: Species
name: ST3GAL3
has only substance units: false

metaR EX fuc L LPAREN e RPAREN
kinetic law: MODEL1310110063#
reactant: MODEL1310110063#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: L-Fucose exchange
type: Reaction

metaR CDIPTr
product: MODEL1310110063#
is described by: ECO:0000000
kinetic law: MODEL1310110063#
is: SBO:0000176
fast: false
reversible: true
type: Reaction
notes: GENE_ASSOCIATION: (10423.1) or (10423.2) SUBSYSTEM: Glycerophospholipid metabolism EC Number: 2.7.8.11 Confidence Level: 4 AUTHORS: PMID:2425833 NOTES:NJ - reversibility of enzyme found in lit by NCD
name: phosphatidylinositol synthase (Homo sapiens)
reactant: MODEL1310110063#
modifier: MODEL1310110063#
is version of: http://identifiers.org/ec-code/2.7.8.11

http://identifiers.org/biomodels.db/MODEL1310110063#_00fbbaa9_c9e8_4cd0_8b8e_7d0284fa1b3f
is encoded by: hsa:112
name: ADCY6
initial concentration: NaN
is: SBO:0000252
type: Species
constant: false
has only substance units: false
initial amount: NaN
boundary condition: true

metaM retinal c
is: SBO:0000247
notes: FORMULA: C20H28O CHARGE: 0 INCHI: InChI=1S/C20H28O/c1-16(8-6-9-17(2)13-15-21)11-12-19-18(3)10-7-14-20(19,4)5/h6,8-9,11-13,15H,7,10,14H2,1-5H3 EHMN_ABBREVIATION: C00376
boundary condition: false
has only substance units: false
initial amount: NaN
is: HMDB01358
name: retinal
initial concentration: 1.0
type: Species
is: CHEBI:15035
constant: false

metaM Lcystin e
boundary condition: false
type: Species
is: CHEBI:16283
initial concentration: 1.0
notes: FORMULA: C6H12N2O4S2 CHARGE: 0 INCHI: InChI=1S/C6H12N2O4S2/c7-3(5(9)10)1-13-14-2-4(8)6(11)12/h3-4H,1-2,7-8H2,(H,9,10)(H,11,12)/t3-,4-/m0/s1
name: L-cystine
is: HMDB00192
constant: false
has only substance units: false
initial amount: NaN
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110063#_80e29055_1688_4b24_921c_8c6d7b4e925e
is: SBO:0000252
initial concentration: NaN
is: Q9NQ66
boundary condition: true
constant: false
is encoded by: hsa:23236
type: Species
name: PLCB1
initial amount: NaN
has only substance units: false

metaR DMATTx
is: SBO:0000176
product: MODEL1310110063#
is version of: http://identifiers.org/ec-code/2.5.1.1
reversible: false
name: dimethylallyltranstransferase
reactant: MODEL1310110063#
type: Reaction
is described by: ECO:0000134
kinetic law: MODEL1310110063#
notes: GENE_ASSOCIATION: (2224.1) SUBSYSTEM: Cholesterol metabolism EC Number: 2.5.1.1 Confidence Level: 4 AUTHORS: PMID:8188698 NOTES:peroxisomal version - NJ
fast: false
modifier: MODEL1310110063#

http://identifiers.org/biomodels.db/MODEL1310110063#_f17294fd_6d09_456f_afd9_f01007d37e4f
boundary condition: true
constant: false
has only substance units: false
is encoded by: hsa:3098
name: HK1
initial concentration: NaN
is: P78542
is: SBO:0000252
type: Species
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110063#_7704d65a_118e_45f2_b24e_0a1bdb773ed4
constant: false
initial concentration: NaN
has only substance units: false
initial amount: NaN
name: TXNRD1
is: SBO:0000252
boundary condition: true
is encoded by: hsa:7296
type: Species

metaM ei11ecoa x
notes: FORMULA: C41H68N7O17P3S CHARGE: -4
name: 11-eicosenoylcoa
constant: false
type: Species
boundary condition: false
initial amount: NaN
is: SBO:0000247
is: http://identifiers.org/pubchem.compound/24892790
initial concentration: 1.0
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110063#_8dcce9ae_17cc_4b11_8771_aec9bfd43c3d
constant: false
is encoded by: hsa:91373
is: Q3KQV9
boundary condition: true
initial amount: NaN
name: UAP1L1
is: SBO:0000252
initial concentration: NaN
has only substance units: false
type: Species

metaM udpgal g
type: Species
constant: false
boundary condition: false
is: SBO:0000247
initial amount: NaN
initial concentration: 1.0
is: CHEBI:58439
name: UDP-D-galactose(2-)
has only substance units: false
is: HMDB00302
notes: FORMULA: C15H22N2O17P2 CHARGE: -2 INCHI: InChI=1S/C15H24N2O17P2/c18-3-5-8(20)10(22)12(24)14(32-5)33-36(28,29)34-35(26,27)30-4-6-9(21)11(23)13(31-6)17-2-1-7(19)16-15(17)25/h1-2,5-6,8-14,18,20-24H,3-4H2,(H,26,27)(H,28,29)(H,16,19,25)/p-2/t5-,6-,8+,9-,10+,11-,12-,13-,14?/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00057 EHMN_ABBREVIATION: C00052

http://identifiers.org/biomodels.db/MODEL1310110063#_db4c2af2_a2ce_4096_af19_877910d3f175
is encoded by: hsa:2820
type: Species
name: GPD2
initial amount: NaN
is: SBO:0000252
constant: false
initial concentration: NaN
is: P43304
has only substance units: false
boundary condition: true

metaR PUNP4
product: MODEL1310110063#
kinetic law: MODEL1310110063#
modifier: MODEL1310110063#
notes: GENE_ASSOCIATION: (4860.1) SUBSYSTEM: Purine catabolism EC Number: 3.4.2.1 Confidence Level: 4 AUTHORS: PMID:6087295,PMID:9305963 NOTES:Specificity not completely determined. Can also catalyse ribosyltransferase reactions of the type catalysed by EC 2.4.2.5, nucleoside ribosyltransferase
is version of: http://identifiers.org/ec-code/2.4.2.1
name: purine-nucleoside phosphorylase (Deoxyguanosine)
reactant: MODEL1310110063#
is described by: ECO:0000269
fast: false
type: Reaction
reversible: true
is: SBO:0000176

metaR FK
is version of: http://identifiers.org/ec-code/2.7.1.52
fast: false
is described by: ECO:0000000
modifier: MODEL1310110063#
reversible: false
kinetic law: MODEL1310110063#
type: Reaction
name: Fucokinase
reactant: MODEL1310110063#
product: MODEL1310110063#
is: SBO:0000176
notes: GENE_ASSOCIATION: (197258.1) SUBSYSTEM: Fructose and mannose metabolism EC Number: 2.7.1.52 Confidence Level: 0 AUTHORS: NOTES:kh 1/6/03 NCD

metaM 2mp2coa m
is: HMDB01011
type: Species
initial concentration: 1.0
has only substance units: false
is: CHEBI:27754
constant: false
notes: FORMULA: C25H36N7O17P3S CHARGE: -4 INCHI: InChI=1S/C25H40N7O17P3S/c1-13(2)24(37)53-8-7-27-15(33)5-6-28-22(36)19(35)25(3,4)10-46-52(43,44)49-51(41,42)45-9-14-18(48-50(38,39)40)17(34)23(47-14)32-12-31-16-20(26)29-11-30-21(16)32/h11-12,14,17-19,23,34-35H,1,5-10H2,2-4H3,(H,27,33)(H,28,36)(H,41,42)(H,43,44)(H2,26,29,30)(H2,38,39,40)/t14-,17-,18-,19+,23-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01122 EHMN_ABBREVIATION: C03460
is: SBO:0000247
initial amount: NaN
name: 2-Methylprop-2-enoyl-CoA
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110063#_370ccfae_8616_4172_9253_220c9b883f02
is: SBO:0000252
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:122970
constant: false
is: Q8N9L9
boundary condition: true
type: Species
has only substance units: false
name: ACOT4

metaR RE0830C
product: MODEL1310110063#
reversible: true
name: RE0830
fast: false
is: SBO:0000176
is described by: ECO:0000000
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Tetrahydrobiopterin metabolism EC Number: 4.2.1.96 Confidence Level: 0 AUTHORS: PMID:10727395,PMID:1355046,PMID:1988938 NOTES:
reactant: MODEL1310110063#
kinetic law: MODEL1310110063#

http://identifiers.org/biomodels.db/MODEL1310110063#_1ad8e2fa_a04f_4326_966e_828d6c29d67a
boundary condition: true
name: AK4
is encoded by: hsa:205
type: Species
is: P27144
constant: false
is: SBO:0000252
has only substance units: false
initial amount: NaN
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110063#_1cb0fac0_ac55_4b3c_90dd_acc1fb83b61d
name: DECR1
is encoded by: hsa:1666
initial concentration: NaN
is: SBO:0000252
type: Species
boundary condition: true
has only substance units: false
constant: false
initial amount: NaN
is: Q16698

metaR OMPDC
kinetic law: MODEL1310110063#
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/2.4.2.10
is: SBO:0000176
type: Reaction
modifier: MODEL1310110063#
notes: GENE_ASSOCIATION: (7372.1) SUBSYSTEM: Pyrimidine synthesis EC Number: 4.1.1.23 Confidence Level: 4 AUTHORS: PMID:3279416,PMID:6574608,PMID:6893554,PMID:9042911 NOTES:
reversible: false
name: orotidine-5'-phosphate decarboxylase
reactant: MODEL1310110063#
product: MODEL1310110063#
fast: false

metaR ARGtm
product: MODEL1310110063#
fast: false
modifier: MODEL1310110063#
kinetic law: MODEL1310110063#
name: arginine mitochondrial transport via ornithine carrier
is described by: ECO:0000269
reversible: true
notes: GENE_ASSOCIATION: (83884.1) or (10166.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172 NOTES:TDV
is: SBO:0000185
reactant: MODEL1310110063#
type: Reaction

metaM eitetcoa x
initial concentration: 1.0
name: 5,8,11,14-eicosatetraenoylcoa
is: SBO:0000247
has only substance units: false
constant: false
boundary condition: false
initial amount: NaN
type: Species
notes: FORMULA: C41H62N7O17P3S CHARGE: -4
is: http://identifiers.org/pubchem.compound/24892790

metaM omhpal c
name: w-hydroxypalmiticacid
constant: false
type: Species
initial amount: NaN
boundary condition: false
is: SBO:0000247
initial concentration: 1.0
notes: FORMULA: C16H30O3 CHARGE: -1
has only substance units: false
is: HMDB06294

metaR PUNP3
type: Reaction
reversible: true
is: SBO:0000176
reactant: MODEL1310110063#
name: purine-nucleoside phosphorylase (Guanosine)
is described by: ECO:0000269
modifier: MODEL1310110063#
fast: false
is version of: http://identifiers.org/ec-code/2.4.2.1
product: MODEL1310110063#
kinetic law: MODEL1310110063#
notes: GENE_ASSOCIATION: (4860.1) SUBSYSTEM: Purine catabolism EC Number: 3.4.2.1 Confidence Level: 4 AUTHORS: PMID:6087295,PMID:9305963 NOTES:Specificity not completely determined. Can also catalyse ribosyltransferase reactions of the type catalysed by EC 2.4.2.5, nucleoside ribosyltransferase

http://identifiers.org/biomodels.db/MODEL1310110063#_80627e1e_a2f3_4e74_96f6_99caf3ccc2e2
is: SBO:0000252
constant: false
boundary condition: true
is encoded by: hsa:9091
has only substance units: false
is: B2RAU6
initial concentration: NaN
name: PIGQ
initial amount: NaN
type: Species

metaR r0224
fast: false
modifier: MODEL1310110063#
kinetic law: MODEL1310110063#
name: 5,6,7,8-Tetrahydrofolate:NAD+ oxidoreductase One carbon pool by folate EC:1.5.1.3
is: SBO:0000176
product: MODEL1310110063#
reactant: MODEL1310110063#
is described by: ECO:0000000
type: Reaction
notes: GENE_ASSOCIATION: (6576.1) SUBSYSTEM: Folate metabolism EC Number: 1.5.1.3 Confidence Level: 0 AUTHORS: PMID:15153070,PMID:1631094,PMID:6882460 NOTES:
reversible: false

metaR CHAT
reversible: true
name: Choline O-acetyltransferase
type: Reaction
reactant: MODEL1310110063#
kinetic law: MODEL1310110063#
notes: GENE_ASSOCIATION: (1103.4) or (1103.2) or (1103.3) or (1103.1) SUBSYSTEM: Glycerophospholipid metabolism EC Number: 2.3.1.6 Confidence Level: 4 AUTHORS: PMID:10861222 NOTES:rev by uniprot NJ
is: SBO:0000176
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/2.3.1.6
modifier: MODEL1310110063#
fast: false
product: MODEL1310110063#

metaR ANTHte
reactant: MODEL1310110063#
name: Transport of anthranilate
product: MODEL1310110063#
fast: false
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
kinetic law: MODEL1310110063#
reversible: true
is: SBO:0000185

metaM CE4791 x
is: CHEBI:57923
type: Species
boundary condition: false
is: SBO:0000247
initial amount: NaN
constant: false
has only substance units: false
name: 3(S)-hydroxy-dihomo-gama-linolenoyl-CoA
notes: FORMULA: C41H64N7O18P3S CHARGE: -4 INCHI: InChI=1/C41H68N7O18P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-29(49)24-32(51)70-23-22-43-31(50)20-21-44-39(54)36(53)41(2,3)26-63-69(60,61)66-68(58,59)62-25-30-35(65-67(55,56)57)34(52)40(64-30)48-28-47-33-37(42)45-27-46-38(33)48/h8-9,11-12,14-15,27-30,34-36,40,49,52-53H,4-7,10,13,16-26H2,1-3H3,(H,43,50)(H,44,54)(H,58,59)(H,60,61)(H2,42,45,46)(H2,55,56,57)/p-4/b9-8-,12-11-,15-14-/t29-,30-,34+,35+,36u,40-/m0/s1 EHMN_ABBREVIATION: CE4791
initial concentration: 1.0

metaM ksi pre27 g
is: CHEBI:58053
type: Species
constant: false
is: HMDB00175
initial concentration: 1.0
boundary condition: false
has only substance units: false
is: C00130
notes: FORMULA: C205H328N14O171S8X CHARGE: -9
initial amount: NaN
is: SBO:0000247
name: keratan sulfate I biosynthesis, precursor 27

metaR r1841
reversible: false
type: Reaction
modifier: MODEL1310110063#
kinetic law: MODEL1310110063#
fast: false
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
name: Y+LAT2 Utilized transport
is: SBO:0000185
is described by: ECO:0000000
reactant: MODEL1310110063#
product: MODEL1310110063#

metaM ala B c
has only substance units: false
is: SBO:0000247
notes: FORMULA: C3H7NO2 CHARGE: 0 INCHI: InChI=1S/C3H7NO2/c4-2-1-3(5)6/h1-2,4H2,(H,5,6) HEPATONET_1.0_ABBREVIATION: HC00100
initial amount: NaN
is: HMDB00056
name: beta-alanine
initial concentration: 1.0
is: CHEBI:16958
boundary condition: false
type: Species
constant: false

metaR FUCtly
name: L-fucose efflux from lysosome
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 2 AUTHORS: PMID:1751541,PMID:8993166 NOTES:
reversible: false
type: Reaction
is: SBO:0000185
fast: false
product: MODEL1310110063#
is described by: ECO:0000000
kinetic law: MODEL1310110063#
reactant: MODEL1310110063#

http://identifiers.org/biomodels.db/MODEL1310110063#_f1ee0eda_5188_48c8_bd23_1b1830e47291
is encoded by: hsa:1339
initial concentration: NaN
name: COX6A2
has only substance units: false
is: SBO:0000252
constant: false
is: Q02221
initial amount: NaN
boundary condition: true
type: Species

metaM man r
initial concentration: 1.0
is: HMDB00169
is: CHEBI:16024
notes: FORMULA: C6H12O6 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00154 EHMN_ABBREVIATION: C00159
has only substance units: false
type: Species
boundary condition: false
initial amount: NaN
constant: false
is: SBO:0000247
name: D-mannose

metaR DPCOAK
is version of: http://identifiers.org/ec-code/2.7.7.3
is: SBO:0000176
modifier: MODEL1310110063#
reactant: MODEL1310110063#
kinetic law: MODEL1310110063#
product: MODEL1310110063#
name: dephospho-CoA kinase
fast: false
reversible: false
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (80347.1) SUBSYSTEM: CoA synthesis EC Number: Confidence Level: 4 AUTHORS: NOTES:
type: Reaction

metaR r1604
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reactant: MODEL1310110063#
fast: false
type: Reaction
product: MODEL1310110063#
reversible: true
is: SBO:0000185
is described by: ECO:0000000
kinetic law: MODEL1310110063#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1

http://identifiers.org/biomodels.db/MODEL1310110063#_e23bd254_2356_43bc_974d_6c17d6886af2
has only substance units: false
is: SBO:0000252
initial amount: NaN
initial concentration: NaN
is: Q02252
name: ALDH6A1
is encoded by: hsa:4329
constant: false
type: Species
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110063#_9a7cf3ad_83fe_4132_a427_bf1bb83ee161
has only substance units: false
name: SLC25A1
initial concentration: NaN
is: SBO:0000252
constant: false
type: Species
is encoded by: hsa:6576
is: D9HTE9
boundary condition: true
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110063#_e32d0dd5_1dfe_4292_a5ca_dce46b028d90
is: P11310
name: ACADM
boundary condition: true
has only substance units: false
is: SBO:0000252
initial concentration: NaN
initial amount: NaN
constant: false
type: Species
is encoded by: hsa:34

metaR CHOLtn
name: Choline transport, nuclear through pores
reactant: MODEL1310110063#
type: Reaction
reversible: true
is: SBO:0000185
product: MODEL1310110063#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: NOTES:it
kinetic law: MODEL1310110063#
is described by: ECO:0000000
fast: false

metaM ptdcacoa m
type: Species
initial amount: NaN
notes: FORMULA: C36H60N7O17P3S CHARGE: -4 INCHI: InChI=1/C36H64N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-27(45)64-20-19-38-26(44)17-18-39-34(48)31(47)36(2,3)22-57-63(54,55)60-62(52,53)56-21-25-30(59-61(49,50)51)29(46)35(58-25)43-24-42-28-32(37)40-23-41-33(28)43/h23-25,29-31,35,46-47H,4-22H2,1-3H3,(H,38,44)(H,39,48)(H,52,53)(H,54,55)(H2,37,40,41)(H2,49,50,51)/p-4/t25-,29-,30-,31+,35-/m0/s1
boundary condition: false
initial concentration: 1.0
constant: false
name: pentadecanoyl Coenzyme A
is: HMDB06499
has only substance units: false
is: SBO:0000247

metaR FAOXMC10OHMC10r
kinetic law: MODEL1310110063#
product: MODEL1310110063#
reactant: MODEL1310110063#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid omega oxidation(MC10-->w-OHMC10)er
type: Reaction

metaM cs e deg7 l
has only substance units: false
type: Species
notes: FORMULA: C23H35O27S2 CHARGE: -3
name: chondroitin sulfate E (GalNAc4,6diS-GlcA), degradation product 7
boundary condition: false
is: SBO:0000247
constant: false
is: CHEBI:15936
initial amount: NaN
initial concentration: 1.0

metaR HIStN1
type: Reaction
notes: GENE_ASSOCIATION: (10991.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10823827,PMID:12845534 NOTES:SAB based om PMID 10823827
is described by: ECO:0000269
fast: false
kinetic law: MODEL1310110063#
modifier: MODEL1310110063#
name: Histidine transport (Na, H coupled)
reactant: MODEL1310110063#
is: SBO:0000185
product: MODEL1310110063#
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110063#_17d99183_f09c_4de4_b1b3_4fa37441ff68
is encoded by: hsa:956
initial concentration: NaN
is: O75355
boundary condition: true
constant: false
type: Species
name: ENTPD3
has only substance units: false
is: SBO:0000252
initial amount: NaN

metaM chol e
is: HMDB00097
initial amount: NaN
boundary condition: false
type: Species
has only substance units: false
is: SBO:0000247
initial concentration: 1.0
constant: false
notes: FORMULA: C5H14NO CHARGE: 1 HEPATONET_1.0_ABBREVIATION: HC00112 EHMN_ABBREVIATION: C00114
is: CHEBI:15354
name: Choline
is: C00114

metaM leuleu e
has only substance units: false
boundary condition: false
is: http://identifiers.org/pubchem.compound/94244
is: SBO:0000247
initial amount: NaN
notes: FORMULA: C12H24N2O3 CHARGE: 0
constant: false
name: Leucylleucine
initial concentration: 1.0
type: Species

metaR FAOXC183806x
modifier: MODEL1310110063#
is: SBO:0000176
fast: false
kinetic law: MODEL1310110063#
reactant: MODEL1310110063#
is version of: http://identifiers.org/ec-code/1.1.1.35
is version of: http://identifiers.org/ec-code/2.3.1.16
is version of: http://identifiers.org/ec-code/4.2.1.107
name: Beta oxidation of long chain fatty acid
is version of: http://identifiers.org/ec-code/1.3.3.6
product: MODEL1310110063#
notes: GENE_ASSOCIATION: (3295.1 and 30.1 and 51.2) or (30.1 and 51.2 and 1962.1) or (51.1 and 3295.1 and 30.1) or (51.1 and 30.1 and 1962.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.74 Confidence Level: 4 AUTHORS: NOTES:_5 rounds of beta ox, 3 degrees loss of saturation -> only 2 fad oxidized to fadh2 - in peroxisome, no fad, 1ste set of beta-ox is by acyl-coa oxidase (passes electrons directly to o2 -> h2o2) peroxisomal (very long chain FA) c18:3,n-6 -> c8:0, 4 step FAO lumped for 2 rounds also includes EC 1.1.1.35, 1.1.1.211, 1.3.3.6, 4.2.1.17, 4.2.1.74 NJ
is described by: ECO:0000269
reversible: false
type: Reaction

metaR r1603
is described by: ECO:0000000
product: MODEL1310110063#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
kinetic law: MODEL1310110063#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
type: Reaction
reversible: true
reactant: MODEL1310110063#
fast: false

metaR RE0512M
is version of: http://identifiers.org/ec-code/4.2.1.17
reversible: true
is version of: http://identifiers.org/ec-code/1.1.1.35
fast: false
kinetic law: MODEL1310110063#
notes: GENE_ASSOCIATION: (3030.1) or (3295.1) or (1962.1) or (3033.1) or (3028.1) or (3032.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.1.1.35 Confidence Level: 0 AUTHORS: PMID:7846063 NOTES:
is described by: ECO:0000000
product: MODEL1310110063#
reactant: MODEL1310110063#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/4.2.1.107
is version of: http://identifiers.org/ec-code/2.3.1.16
name: RE0512
modifier: MODEL1310110063#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110063#_25299a77_3f5c_4f3c_b437_5029b8753a0b
initial amount: NaN
name: SLC4A3
boundary condition: true
type: Species
is: SBO:0000252
has only substance units: false
constant: false
is encoded by: hsa:6508
initial concentration: NaN
is: P48751

metaM 3decdicoa x
name: 3,7-decadienoylcoa
boundary condition: false
constant: false
type: Species
has only substance units: false
notes: FORMULA: C31H46N7O17P3S CHARGE: -4
is: SBO:0000247
initial amount: NaN
initial concentration: 1.0
is: http://identifiers.org/pubchem.compound/16019966

metaM hpdcacrn m
initial amount: NaN
type: Species
boundary condition: false
has only substance units: false
is: HMDB06210
name: heptadecanoyl carnitine
initial concentration: 1.0
is: SBO:0000247
notes: FORMULA: C24H47NO4 CHARGE: 0 INCHI: InChI=1/C24H47NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-24(28)29-22(20-23(26)27)21-25(2,3)4/h22H,5-21H2,1-4H3
constant: false

metaR ACCOAtn
reactant: MODEL1310110063#
kinetic law: MODEL1310110063#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD
reversible: true
type: Reaction
product: MODEL1310110063#
name: acetyl-CoA transport, nuclear
fast: false
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110063#_a25e76d6_4ebb_4e37_9741_576de7fd8273
constant: false
type: Species
has only substance units: false
initial amount: NaN
is: P30838
name: ALDH3A1
boundary condition: true
is encoded by: hsa:218
is: SBO:0000252
initial concentration: NaN

metaR ACACT10m
modifier: MODEL1310110063#
name: acetyl-CoA C-acetyltransferase, mitochondrial
is described by: ECO:0000134
reversible: true
product: MODEL1310110063#
is version of: http://identifiers.org/ec-code/2.3.1.9
is: SBO:0000176
reactant: MODEL1310110063#
notes: GENE_ASSOCIATION: (38.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 2.3.1.9 Confidence Level: 4 AUTHORS: PMID:676035 NOTES:MM. 2-Methyl-3-acetoacetyl-CoA excreted into urine for patients with disease deficiency
type: Reaction
kinetic law: MODEL1310110063#
fast: false

metaM 3otdcoa m
name: 3-Oxotetradecanoyl-CoA
is: HMDB03935
initial amount: NaN
constant: false
is: SBO:0000247
type: Species
initial concentration: 1.0
is: CHEBI:28726
boundary condition: false
has only substance units: false
notes: FORMULA: C35H56N7O18P3S CHARGE: -4 INCHI: InChI=1S/C35H60N7O18P3S/c1-4-5-6-7-8-9-10-11-12-13-23(43)18-26(45)64-17-16-37-25(44)14-15-38-33(48)30(47)35(2,3)20-57-63(54,55)60-62(52,53)56-19-24-29(59-61(49,50)51)28(46)34(58-24)42-22-41-27-31(36)39-21-40-32(27)42/h21-22,24,28-30,34,46-47H,4-20H2,1-3H3,(H,37,44)(H,38,48)(H,52,53)(H,54,55)(H2,36,39,40)(H2,49,50,51)/t24-,28-,29-,30+,34-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01400 EHMN_ABBREVIATION: C05261

metaM tetde5coa x
constant: false
is: HMDB11123
type: Species
boundary condition: false
initial concentration: 1.0
has only substance units: false
notes: FORMULA: C35H56N7O17P3S CHARGE: -4
is: SBO:0000247
name: 5-tetradecenoylcoa
is: C05279
initial amount: NaN

metaM udpgal c
constant: false
initial concentration: 1.0
boundary condition: false
is: CHEBI:58439
is: HMDB00302
initial amount: NaN
notes: FORMULA: C15H22N2O17P2 CHARGE: -2 INCHI: InChI=1S/C15H24N2O17P2/c18-3-5-8(20)10(22)12(24)14(32-5)33-36(28,29)34-35(26,27)30-4-6-9(21)11(23)13(31-6)17-2-1-7(19)16-15(17)25/h1-2,5-6,8-14,18,20-24H,3-4H2,(H,26,27)(H,28,29)(H,16,19,25)/p-2/t5-,6-,8+,9-,10+,11-,12-,13-,14?/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00057 EHMN_ABBREVIATION: C00052
type: Species
has only substance units: false
is: SBO:0000247
name: UDP-D-galactose(2-)

metaR EX urate LPAREN e RPAREN
kinetic law: MODEL1310110063#
reactant: MODEL1310110063#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Urate exchange
type: Reaction

metaR DNDPt24m
is: SBO:0000185
kinetic law: MODEL1310110063#
type: Reaction
notes: GENE_ASSOCIATION: (60386.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:11226231 NOTES:IT
reactant: MODEL1310110063#
is described by: ECO:0000269
name: dTDP transport via dADP antiport
product: MODEL1310110063#
fast: false
reversible: false
modifier: MODEL1310110063#

http://identifiers.org/biomodels.db/MODEL1310110063#_e100fd64_b28f_4ef9_b3f6_2163efa09f33
boundary condition: true
type: Species
is: SBO:0000252
name: FOLR1
initial amount: NaN
is encoded by: hsa:2348
constant: false
has only substance units: false
initial concentration: NaN

metaM cholcoa c
is: SBO:0000247
initial amount: NaN
has only substance units: false
constant: false
type: Species
is: CHEBI:57373
boundary condition: false
is: HMDB01374
initial concentration: 1.0
name: choloyl-CoA(4-)
notes: FORMULA: C45H70N7O20P3S CHARGE: -4 INCHI: InChI=1S/C45H74N7O20P3S/c1-23(26-7-8-27-34-28(18-31(55)45(26,27)5)44(4)12-10-25(53)16-24(44)17-29(34)54)6-9-33(57)76-15-14-47-32(56)11-13-48-41(60)38(59)43(2,3)20-69-75(66,67)72-74(64,65)68-19-30-37(71-73(61,62)63)36(58)42(70-30)52-22-51-35-39(46)49-21-50-40(35)52/h21-31,34,36-38,42,53-55,58-59H,6-20H2,1-5H3,(H,47,56)(H,48,60)(H,64,65)(H,66,67)(H2,46,49,50)(H2,61,62,63)/p-4/t23-,24+,25-,26-,27+,28+,29-,30-,31+,34+,36-,37-,38+,42-,44+,45-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00844 EHMN_ABBREVIATION: C01794

metaM ala B e
is: CHEBI:16958
initial amount: NaN
type: Species
constant: false
is: SBO:0000247
boundary condition: false
has only substance units: false
initial concentration: 1.0
name: beta-alanine
is: HMDB00056
notes: FORMULA: C3H7NO2 CHARGE: 0 INCHI: InChI=1S/C3H7NO2/c4-2-1-3(5)6/h1-2,4H2,(H,5,6) HEPATONET_1.0_ABBREVIATION: HC00100

metaR MHISOR
kinetic law: MODEL1310110063#
product: MODEL1310110063#
type: Reaction
is: SBO:0000176
reversible: false
fast: false
name: N-Methylhistamine:oxygen oxidoreductase (deaminating)
modifier: MODEL1310110063#
is version of: http://identifiers.org/ec-code/1.4.3.21
reactant: MODEL1310110063#
is version of: http://identifiers.org/ec-code/1.4.3.22
notes: GENE_ASSOCIATION: (26.1) or (314.1) or (8639.1) or (314.2) SUBSYSTEM: Histidine metabolism EC Number: 1.4.3.4 Confidence Level: 4 AUTHORS: PMID:12072962,PMID:15035803,PMID:8920635,PMID:9653080 NOTES:
is described by: ECO:0000269

metaR CRNt
reactant: MODEL1310110063#
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (6584.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12827517,PMID:12883891,PMID:9933568 NOTES:NCD
type: Reaction
product: MODEL1310110063#
modifier: MODEL1310110063#
fast: false
name: L-carnitine reversible transport
is: SBO:0000185
kinetic law: MODEL1310110063#
reversible: true

metaM occoa m
constant: false
boundary condition: false
is: HMDB01070
notes: FORMULA: C29H46N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00869 EHMN_ABBREVIATION: C01944
type: Species
is: SBO:0000247
initial amount: NaN
is: CHEBI:57386
is: C01944
has only substance units: false
initial concentration: 1.0
name: Octanoyl-CoA (n-C8:0CoA)

http://identifiers.org/biomodels.db/MODEL1310110063#_1a56b975_9756_4993_a4fd_94588aabf6e8
boundary condition: true
is encoded by: hsa:123041
name: SLC24A4
type: Species
has only substance units: false
initial concentration: NaN
constant: false
initial amount: NaN
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110063#_0f7c0ad7_14df_4840_aff2_667363a37110
initial concentration: NaN
is encoded by: hsa:6519
has part: Q07837
has part: P82251
name: SLC7A9:SLC3A1
is: SBO:0000297
constant: false
boundary condition: true
type: Species
is encoded by: hsa:11136
initial amount: NaN
has only substance units: false

metaM ksi pre20 g
is: SBO:0000247
is: CHEBI:28067
type: Species
boundary condition: false
initial amount: NaN
name: keratan sulfate I biosynthesis, precursor 20
notes: FORMULA: C171H274N12O140S6X CHARGE: -7
has only substance units: false
constant: false
initial concentration: 1.0

metaR OIVD3m
is version of: http://identifiers.org/ec-code/1.2.4.4
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.8.1.4
is described by: ECO:0000269
kinetic law: MODEL1310110063#
fast: false
reactant: MODEL1310110063#
product: MODEL1310110063#
type: Reaction
modifier: MODEL1310110063#
is version of: http://identifiers.org/ec-code/2.3.1.168
name: 2-oxoisovalerate dehydrogenase (acylating; 3-methyl-2-oxopentanoate), mitochondrial
notes: GENE_ASSOCIATION: (1629.1) and (594.1 and 593.1) and (1738.1) or (1629.1) and (1738.1) and (594.2 and 593.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 1.8.1.4 Confidence Level: 4 AUTHORS: PMID:1429740,PMID:2914958 NOTES:
reversible: false

metaR LNLNCGt
product: MODEL1310110063#
name: fatty acid transport via diffusion
is: SBO:0000185
type: Reaction
kinetic law: MODEL1310110063#
reactant: MODEL1310110063#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11788354,PMID:12864740 NOTES:NJ
is described by: ECO:0000000
reversible: true
fast: false

http://identifiers.org/biomodels.db/MODEL1310110063#_d48d7f2c_382e_4682_9f68_6d36fb41b718
is: SBO:0000252
initial concentration: NaN
boundary condition: true
name: _AI990637_1_x
constant: false
has only substance units: false
is encoded by: hsa:AI990637
initial amount: NaN
type: Species

metaR G14T8g
reactant: MODEL1310110063#
kinetic law: MODEL1310110063#
modifier: MODEL1310110063#
product: MODEL1310110063#
fast: false
notes: GENE_ASSOCIATION: (8703.1) or (2683.1) or (8704.2) or (8704.1) or (9334.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.38 Confidence Level: 4 AUTHORS: PMID:12512857,PMID:1903938,PMID:3094506,PMID:3144273,PMID:9405390,PMID:9435216 NOTES:Keratan sulfate I biosynthesis NCD
name: beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase, Golgi
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/2.4.1.22
is: SBO:0000176
type: Reaction
is version of: http://identifiers.org/ec-code/2.4.1.38
reversible: false
is version of: http://identifiers.org/ec-code/2.4.1.90

metaM 3mob c
is: SBO:0000247
initial amount: NaN
notes: FORMULA: C5H7O3 CHARGE: -1 INCHI: InChI=1S/C5H8O3/c1-3(2)4(6)5(7)8/h3H,1-2H3,(H,7,8)/p-1 HEPATONET_1.0_ABBREVIATION: HC00139 EHMN_ABBREVIATION: C00141
type: Species
name: 3-methyl-2-oxobutanoate
constant: false
is: HMDB00019
is: CHEBI:11851
has only substance units: false
initial concentration: 1.0
boundary condition: false

metaR r1602
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reactant: MODEL1310110063#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
type: Reaction
fast: false
kinetic law: MODEL1310110063#
product: MODEL1310110063#
is described by: ECO:0000000
is: SBO:0000185
reversible: true

metaM clpndcoa c
is: HMDB06267
initial amount: NaN
has only substance units: false
boundary condition: false
constant: false
is: http://identifiers.org/pubchem.compound/47205476
name: clupanodonyl CoA
is: C16166
is: SBO:0000247
notes: FORMULA: C43H64N7O17P3S CHARGE: -4 INCHI: InChI=1/C43H68N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-34(52)71-27-26-45-33(51)24-25-46-41(55)38(54)43(2,3)29-64-70(61,62)67-69(59,60)63-28-32-37(66-68(56,57)58)36(53)42(65-32)50-31-49-35-39(44)47-30-48-40(35)50/h5-6,8-9,11-12,14-15,17-18,30-32,36-38,42,53-54H,4,7,10,13,16,19-29H2,1-3H3,(H,45,51)(H,46,55)(H,59,60)(H,61,62)(H2,44,47,48)(H2,56,57,58)/p-4/b6-5-,9-8-,12-11-,15-14-,18-17-/t32-,36+,37+,38?,42-/m0/s1
type: Species
initial concentration: 1.0

metaR G14T15g
is version of: http://identifiers.org/ec-code/2.4.1.38
fast: false
type: Reaction
is described by: ECO:0000000
kinetic law: MODEL1310110063#
modifier: MODEL1310110063#
name: beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase, Golgi
reactant: MODEL1310110063#
reversible: false
product: MODEL1310110063#
notes: GENE_ASSOCIATION: (8703.1) or (2683.1) or (8704.2) or (8704.1) or (9334.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.38 Confidence Level: 4 AUTHORS: PMID:12512857,PMID:1903938,PMID:3094506,PMID:3144273,PMID:9405390,PMID:9435216 NOTES:Keratan sulfate I biosynthesis NCD
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.4.1.90
is version of: http://identifiers.org/ec-code/2.4.1.22

metaR MAN1PT2
reversible: false
is version of: http://identifiers.org/ec-code/2.7.7.13
product: MODEL1310110063#
kinetic law: MODEL1310110063#
type: Reaction
is described by: ECO:0000000
name: mannose-1-phosphate guanylyltransferase (GDP)
modifier: MODEL1310110063#
fast: false
notes: GENE_ASSOCIATION: (29926.2) or (29926.1) or (29925.2) or (29925.1) SUBSYSTEM: Fructose and mannose metabolism EC Number: 2.7.7.22 Confidence Level: 0 AUTHORS: NOTES:JLR
is: SBO:0000176
reactant: MODEL1310110063#

metaR EX mercplaccys LPAREN e RPAREN
kinetic law: MODEL1310110063#
reactant: MODEL1310110063#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 3-mercaptolactate-cysteine disulfide exchange
type: Reaction

metaR GLNSERNaEx
name: L-serine/L-glutamine Na-dependent exchange (Gln-L in)
is described by: ECO:0000269
fast: false
is: SBO:0000185
product: MODEL1310110063#
notes: GENE_ASSOCIATION: (6510.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14530974 NOTES:SAB see Kanai and Hediger 2004 (2003), PMID 14530974
modifier: MODEL1310110063#
reactant: MODEL1310110063#
kinetic law: MODEL1310110063#
type: Reaction
reversible: false

metaR r0450
type: Reaction
name: L-2-Aminoadipate:2-oxoglutarate aminotransferase Lysine biosynthesis / Lysine degradation EC:2.6.1.39
is version of: http://identifiers.org/ec-code/4.2.1.3
product: MODEL1310110063#
reversible: true
modifier: MODEL1310110063#
notes: GENE_ASSOCIATION: (AA278423.1) or (48.1) or (50.1) SUBSYSTEM: Lysine metabolism EC Number: 2.6.1.39 Confidence Level: 0 AUTHORS: PMID:8087205 NOTES:
reactant: MODEL1310110063#
is: SBO:0000176
is described by: ECO:0000000
kinetic law: MODEL1310110063#
fast: false

metaM chol c
is: HMDB00097
notes: FORMULA: C5H14NO CHARGE: 1 HEPATONET_1.0_ABBREVIATION: HC00112 EHMN_ABBREVIATION: C00114
is: C00114
initial amount: NaN
name: Choline
is: SBO:0000247
constant: false
boundary condition: false
initial concentration: 1.0
has only substance units: false
is: CHEBI:15354
type: Species

http://identifiers.org/biomodels.db/MODEL1310110063#_c1078b8f_b13a_42eb_9dc6_6c8aa17d38ab
initial concentration: NaN
constant: false
type: Species
has only substance units: false
is encoded by: hsa:5152
name: PDE9A
is: SBO:0000252
boundary condition: true
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110063#_e009facb_01bc_4262_8b02_b762c05b8565
boundary condition: true
is: C9JZ62
is: SBO:0000252
type: Species
constant: false
has only substance units: false
is encoded by: hsa:641649
initial concentration: NaN
initial amount: NaN
name: TMEM91

metaR r0345
reactant: MODEL1310110063#
type: Reaction
modifier: MODEL1310110063#
name: ATP:AMP phosphotransferase Purine metabolism EC:2.7.4.11
notes: GENE_ASSOCIATION: (27034.1) or (28976.1) or (33.1) or (34.1) or (37.1) or (51.1) or (8310.1) or (AI285872.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.11 Confidence Level: 0 AUTHORS: PMID:11768308 NOTES:
is version of: http://identifiers.org/ec-code/1.3.3.6
reversible: true
product: MODEL1310110063#
is version of: http://identifiers.org/ec-code/1.3.99.3
fast: false
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.3.99.13
kinetic law: MODEL1310110063#
is described by: ECO:0000000

metaR NDPK9n
is described by: ECO:0000269
product: MODEL1310110063#
reversible: true
kinetic law: MODEL1310110063#
type: Reaction
name: nucleoside-diphosphate kinase (ATP:IDP), nuclear
is: SBO:0000176
reactant: MODEL1310110063#
is version of: http://identifiers.org/ec-code/2.7.4.6
notes: GENE_ASSOCIATION: (4831.1 and 4830.1) or (4830.2 and 4831.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.6 Confidence Level: 4 AUTHORS: NOTES:NCD
modifier: MODEL1310110063#
fast: false

metaR r2328
reversible: true
is described by: ECO:0000000
product: MODEL1310110063#
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
is: SBO:0000185
fast: false
type: Reaction
kinetic law: MODEL1310110063#
reactant: MODEL1310110063#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110063#_72497343_8db6_4b7a_857b_822ceee4e8c8
boundary condition: true
is encoded by: hsa:374291
initial amount: NaN
is: SBO:0000252
name: NDUFS7
constant: false
type: Species
has only substance units: false
is: O75251
initial concentration: NaN

metaR RE3272N
fast: false
reversible: true
kinetic law: MODEL1310110063#
reactant: MODEL1310110063#
name: RE3272
notes: GENE_ASSOCIATION: SUBSYSTEM: Phosphatidylinositol phosphate metabolism EC Number: 3.1.3.66 Confidence Level: 0 AUTHORS: PMID:7556092 NOTES:
is described by: ECO:0000000
is: SBO:0000176
product: MODEL1310110063#
type: Reaction

metaM acald c
is: CHEBI:15343
initial concentration: 1.0
initial amount: NaN
type: Species
is: SBO:0000247
boundary condition: false
constant: false
is: HMDB00990
notes: FORMULA: C2H4O CHARGE: 0 INCHI: InChI=1S/C2H4O/c1-2-3/h2H,1H3 HEPATONET_1.0_ABBREVIATION: HC00087 EHMN_ABBREVIATION: C00084
has only substance units: false
name: acetaldehyde

http://identifiers.org/biomodels.db/MODEL1310110063#_4a178a6c_58cc_4f91_ac36_3dc9fb75c7bc
initial concentration: NaN
type: Species
initial amount: NaN
boundary condition: true
has only substance units: false
name: BPNT1
is encoded by: hsa:10380
is: SBO:0000252
is: O95861
constant: false

metaR FAOXC183806m
reversible: false
name: Beta oxidation of fatty acid
is version of: http://identifiers.org/ec-code/1.3.99.3
modifier: MODEL1310110063#
is version of: http://identifiers.org/ec-code/1.3.8.1
reactant: MODEL1310110063#
is: SBO:0000176
kinetic law: MODEL1310110063#
product: MODEL1310110063#
is described by: ECO:0000269
type: Reaction
fast: false
notes: GENE_ASSOCIATION: (34.1) or (35.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.74 Confidence Level: 4 AUTHORS: NOTES:_5 rounds of beta ox, 3 degrees loss of saturation -> only 2 fad oxidized to fadh2 - in peroxisome, no fad, 1ste set of beta-ox is by acyl-coa oxidase (passes electrons directly to o2 -> h2o2) peroxisomal (very long chain FA) c18:3,n-6 -> c8:0, 4 step FAO lumped for 2 rounds also includes EC 1.1.1.35, 1.1.1.211, 1.3.3.6, 4.2.1.17, 4.2.1.74 NJ

metaR AG13T8g
name: N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase, Golgi apparatus
product: MODEL1310110063#
type: Reaction
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/2.4.1.149
modifier: MODEL1310110063#
fast: false
kinetic law: MODEL1310110063#
notes: GENE_ASSOCIATION: (79369.1) or (374907.1) or (11041.1) or (146712.1) or (374907.2) or (93010.1) or (10331.1) or (10678.1) or (10678.2) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.149 Confidence Level: 4 AUTHORS: PMID:10747980,PMID:11042166,PMID:12061784,PMID:12512857,PMID:15560372,PMID:15620693,PMID:9405606 NOTES:NCD
reactant: MODEL1310110063#
is: SBO:0000176
reversible: false

metaM elaid c
is: CHEBI:30825
type: Species
is: HMDB00573
constant: false
has only substance units: false
is: SBO:0000247
boundary condition: false
initial amount: NaN
notes: FORMULA: C18H33O2 CHARGE: -1 INCHI: InChI=1S/C18H34O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20/h9-10H,2-8,11-17H2,1H3,(H,19,20)/p-1/b10-9+ HEPATONET_1.0_ABBREVIATION: HC00830
initial concentration: 1.0
name: elaidate

metaR r2329
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
is described by: ECO:0000000
reactant: MODEL1310110063#
fast: false
product: MODEL1310110063#
kinetic law: MODEL1310110063#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
is: SBO:0000185
type: Reaction
reversible: true

metaR MM5cg
is: SBO:0000176
kinetic law: MODEL1310110063#
fast: false
product: MODEL1310110063#
type: Reaction
is described by: ECO:0000000
reversible: false
name: mannosyl-oligosaccharide 1,2-alpha-mannosidase, Golgi apparatus
notes: GENE_ASSOCIATION: (4121.1) or (57134.1) or (10905.1) SUBSYSTEM: N-glycan synthesis EC Number: 3.2.1.113 Confidence Level: 0 AUTHORS: PMID:10915796,PMID:9592125 NOTES:NCD
modifier: MODEL1310110063#
reactant: MODEL1310110063#
is version of: http://identifiers.org/ec-code/3.2.1.113

metaR OIVD1m
type: Reaction
reactant: MODEL1310110063#
modifier: MODEL1310110063#
is version of: http://identifiers.org/ec-code/1.2.4.4
kinetic law: MODEL1310110063#
is: SBO:0000176
product: MODEL1310110063#
name: 2-oxoisovalerate dehydrogenase (acylating; 4-methyl-2-oxopentaoate), mitochondrial
fast: false
is version of: http://identifiers.org/ec-code/1.8.1.4
reversible: false
notes: GENE_ASSOCIATION: (1629.1) and (594.1 and 593.1) and (1738.1) or (1629.1) and (1738.1) and (594.2 and 593.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 1.8.1.4 Confidence Level: 4 AUTHORS: PMID:1429740,PMID:2914958 NOTES:
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/2.3.1.168

metaR DURAD2
modifier: MODEL1310110063#
name: dihydrothymin dehydrogenase (NADP)
product: MODEL1310110063#
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/1.3.1.2
fast: false
reversible: true
type: Reaction
is: SBO:0000176
kinetic law: MODEL1310110063#
reactant: MODEL1310110063#
notes: GENE_ASSOCIATION: (1806.1) SUBSYSTEM: Pyrimidine catabolism EC Number: 1.3.1.2 Confidence Level: 4 AUTHORS: PMID:1512248,PMID:8221682 NOTES:_01-26-05 IT based on Lu et al., JBC,1992,24,17102-17109

http://identifiers.org/biomodels.db/MODEL1310110063#_815e14fc_1d04_4cbd_b2d0_1f1a79c4010b
constant: false
type: Species
is: Q9BZM2
has only substance units: false
name: PLA2G2F
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:64600
initial concentration: NaN
boundary condition: true

metaR SUBERCACT
kinetic law: MODEL1310110063#
product: MODEL1310110063#
reactant: MODEL1310110063#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: transport of suberyl carnitine into cytosol
type: Reaction

metaR NAtx
product: MODEL1310110063#
fast: false
reactant: MODEL1310110063#
name: sodium transport via diffusion (perioxisome)
is: SBO:0000185
is described by: ECO:0000000
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 1 AUTHORS: NOTES:SAB
reversible: true
kinetic law: MODEL1310110063#

metaR G14T6g
reversible: false
kinetic law: MODEL1310110063#
is version of: http://identifiers.org/ec-code/2.4.1.38
type: Reaction
is version of: http://identifiers.org/ec-code/2.4.1.22
is: SBO:0000176
modifier: MODEL1310110063#
is described by: ECO:0000000
product: MODEL1310110063#
notes: GENE_ASSOCIATION: (8703.1) or (2683.1) or (8704.2) or (8704.1) or (9334.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.38 Confidence Level: 4 AUTHORS: PMID:12512857,PMID:1903938,PMID:3094506,PMID:3144273,PMID:9405390,PMID:9435216 NOTES:Keratan sulfate I biosynthesis NCD
name: beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase, Golgi
reactant: MODEL1310110063#
is version of: http://identifiers.org/ec-code/2.4.1.90
fast: false

metaR EX 10fthf5glu LPAREN e RPAREN
kinetic law: MODEL1310110063#
reactant: MODEL1310110063#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 10-formyltetrahydrofolate-[Glu](5) exchange
type: Reaction

metaM h r
boundary condition: false
is: SBO:0000247
is: C00080
initial amount: NaN
initial concentration: 1.0
type: Species
constant: false
name: proton
notes: FORMULA: H CHARGE: 1 INCHI: " HEPATONET_1.0_ABBREVIATION: HC00083 EHMN_ABBREVIATION: C00080
is: CHEBI:24636
is: http://identifiers.org/pubchem.compound/3380
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110063#_5bf08aee_2237_413c_97b6_337990ea0261
boundary condition: true
has only substance units: false
name: GLA
constant: false
is: Q53Y83
initial amount: NaN
is encoded by: hsa:2717
type: Species
is: SBO:0000252
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110063#_2a71cdea_7f2d_4062_a874_80d469fa3951
initial concentration: NaN
boundary condition: true
has only substance units: false
is: Q59HH3
type: Species
constant: false
initial amount: NaN
is: SBO:0000252
name: GART
is encoded by: hsa:2618

metaM man l
is: SBO:0000247
boundary condition: false
type: Species
constant: false
has only substance units: false
name: D-mannose
initial concentration: 1.0
notes: FORMULA: C6H12O6 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00154 EHMN_ABBREVIATION: C00159
initial amount: NaN
is: CHEBI:16024
is: HMDB00169

http://identifiers.org/biomodels.db/MODEL1310110063#_d1b92554_646d_4213_8a3a_fa5cd8b5feb1
is encoded by: hsa:AI971036
initial amount: NaN
boundary condition: true
initial concentration: NaN
has only substance units: false
constant: false
name: _AI971036_1_c
type: Species
is: SBO:0000252

metaR r0553
reactant: MODEL1310110063#
kinetic law: MODEL1310110063#
fast: false
is: SBO:0000176
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Glycine, serine, alanine and threonine metabolism EC Number: 1.2.1.8 Confidence Level: 0 AUTHORS: PMID:10505788,PMID:7646513 NOTES:
product: MODEL1310110063#
type: Reaction
is described by: ECO:0000000
name: p-Cumic alcohol:NADP+ oxidoreductase Glycine, serine and threonine metabolism EC:1.2.1.8

metaR RE1534M
product: MODEL1310110063#
name: RE1534
notes: GENE_ASSOCIATION: (10449.1) or (3032.1) or (3030.1) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.16 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:7923814,PMID:9568246,PMID:9920399 NOTES:
modifier: MODEL1310110063#
kinetic law: MODEL1310110063#
fast: false
reversible: true
is: SBO:0000176
reactant: MODEL1310110063#
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/2.3.1.16
is version of: http://identifiers.org/ec-code/4.2.1.17
type: Reaction

metaM CE2417 m
constant: false
name: 3(S)-hydroxy-5Z,8Z-tetradecadienoyl-CoA
is: CHEBI:28387
is: SBO:0000247
type: Species
notes: FORMULA: C35H54N7O18P3S CHARGE: -4 INCHI: InChI=1/C35H58N7O18P3S/c1-4-5-6-7-8-9-10-11-12-13-23(43)18-26(45)64-17-16-37-25(44)14-15-38-33(48)30(47)35(2,3)20-57-63(54,55)60-62(52,53)56-19-24-29(59-61(49,50)51)28(46)34(58-24)42-22-41-27-31(36)39-21-40-32(27)42/h8-9,11-12,21-24,28-30,34,43,46-47H,4-7,10,13-20H2,1-3H3,(H,37,44)(H,38,48)(H,52,53)(H,54,55)(H2,36,39,40)(H2,49,50,51)/p-4/b9-8-,12-11-/t23-,24-,28+,29+,30u,34-/m0/s1 EHMN_ABBREVIATION: CE2417
has only substance units: false
is: HMDB11123
initial amount: NaN
initial concentration: 1.0
boundary condition: false

metaM 2hexdtetcoa x
is: SBO:0000247
name: 2,7,10,13-hexadecatetraenoylcoa
initial amount: NaN
constant: false
boundary condition: false
is: HMDB02288
has only substance units: false
type: Species
notes: FORMULA: C37H54N7O17P3S CHARGE: -4
initial concentration: 1.0

metaR FATP1t
type: Reaction
fast: false
reactant: MODEL1310110063#
modifier: MODEL1310110063#
is described by: ECO:0000269
kinetic law: MODEL1310110063#
is: SBO:0000185
product: MODEL1310110063#
notes: GENE_ASSOCIATION: (376497.2) or (10999.1) or (376497.1) or (11000.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12856180,PMID:15522816,PMID:9878842 NOTES:electroneutral transport NJ
reversible: true
name: fatty acid electroneutral transport

http://identifiers.org/biomodels.db/MODEL1310110063#_153869e1_521e_491f_a397_284b6cffbfcb
type: Species
boundary condition: true
is: SBO:0000252
initial amount: NaN
constant: false
name: SLC22A2
initial concentration: NaN
has only substance units: false
is encoded by: hsa:6582

metaR r2326
product: MODEL1310110063#
is described by: ECO:0000000
fast: false
is: SBO:0000185
kinetic law: MODEL1310110063#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
type: Reaction
reactant: MODEL1310110063#
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
reversible: true

metaR OCD11CRNCACT
kinetic law: MODEL1310110063#
product: MODEL1310110063#
reactant: MODEL1310110063#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: transport of 11-octadecenoyl carnitine into the mitochondrial matrix
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110063#_24e267f0_4f48_45be_b735_45b4fdafdce1
type: Species
has only substance units: false
is encoded by: hsa:56894
boundary condition: true
is: SBO:0000252
initial concentration: NaN
initial amount: NaN
is: Q9NRZ7
constant: false
name: AGPAT3

metaR NACHEX3ly
reactant: MODEL1310110063#
name: beta-N-acetylhexosaminidase, lysosomal
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/3.2.1.52
fast: false
product: MODEL1310110063#
reversible: false
modifier: MODEL1310110063#
is: SBO:0000176
kinetic law: MODEL1310110063#
type: Reaction
notes: GENE_ASSOCIATION: (3073.1) or (3073.1 and 3074.1) or (3074.1) SUBSYSTEM: Chondroitin sulfate degradation EC Number: 3.2.1.52 Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12706724,PMID:8993162 NOTES:NCD

metaM 3dphb m
constant: false
is: SBO:0000247
type: Species
has only substance units: false
initial amount: NaN
is: HMDB06251
name: 3-Decaprenyl-4-hydroxybenzoate
boundary condition: false
notes: FORMULA: C57H85O3 CHARGE: -1 INCHI: InChI=1/C57H86O3/c1-44(2)21-12-22-45(3)23-13-24-46(4)25-14-26-47(5)27-15-28-48(6)29-16-30-49(7)31-17-32-50(8)33-18-34-51(9)35-19-36-52(10)37-20-38-53(11)39-40-54-43-55(57(59)60)41-42-56(54)58/h21,23,25,27,29,31,33,35,37,39,41-43,58H,12-20,22,24,26,28,30,32,34,36,38,40H2,1-11H3,(H,59,60)/b45-23+,46-25+,47-27+,48-29+,49-31+,50-33+,51-35+,52-37+,53-39+
initial concentration: 1.0

metaM Ssq23epx r
constant: false
notes: FORMULA: C30H50O CHARGE: 0 INCHI: InChI=1S/C30H50O/c1-24(2)14-11-17-27(5)20-12-18-25(3)15-9-10-16-26(4)19-13-21-28(6)22-23-29-30(7,8)31-29/h14-16,20-21,29H,9-13,17-19,22-23H2,1-8H3/b25-15+,26-16+,27-20+,28-21+/t29-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00645 EHMN_ABBREVIATION: C01054
type: Species
boundary condition: false
name: (S)-2,3-epoxysqualene
has only substance units: false
is: HMDB01188
initial amount: NaN
is: CHEBI:15441
initial concentration: 1.0
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110063#_e24c133c_bd93_45aa_abf7_5879eace322e
boundary condition: true
has only substance units: false
type: Species
is encoded by: hsa:5291
name: PIK3CB
initial concentration: NaN
is: B4DER4
is: SBO:0000252
initial amount: NaN
constant: false

metaM tchola e
type: Species
constant: false
is: HMDB00036
is: SBO:0000247
boundary condition: false
notes: FORMULA: C26H45NO7S CHARGE: 0
initial amount: NaN
initial concentration: 1.0
name: taurocholic acid
has only substance units: false

metaM acald e
name: acetaldehyde
initial amount: NaN
is: SBO:0000247
constant: false
type: Species
initial concentration: 1.0
boundary condition: false
is: HMDB00990
notes: FORMULA: C2H4O CHARGE: 0 INCHI: InChI=1S/C2H4O/c1-2-3/h2H,1H3 HEPATONET_1.0_ABBREVIATION: HC00087 EHMN_ABBREVIATION: C00084
is: CHEBI:15343
has only substance units: false

metaR HTDCRNe
kinetic law: MODEL1310110063#
product: MODEL1310110063#
reactant: MODEL1310110063#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of 3-hydroxy-tetradecanoyl carnitine into extra cellular space
type: Reaction

metaM ksi deg7 l
initial amount: NaN
notes: FORMULA: C210H337N15O181S10 CHARGE: -10
is: CHEBI:57455
name: keratan sulfate I, degradation product 7
is: HMDB01354
boundary condition: false
constant: false
type: Species
initial concentration: 1.0
is: SBO:0000247
has only substance units: false

metaR r0552
is described by: ECO:0000000
product: MODEL1310110063#
is: SBO:0000176
reversible: true
notes: GENE_ASSOCIATION: (AF080579.1) or (AI348006.1) or (6389.1) or (6390.1) or (6391.1) or (6392.1) or (642502.1) SUBSYSTEM: Glycine, serine, alanine and threonine metabolism EC Number: 1.2.1.8 Confidence Level: 0 AUTHORS: PMID:10505788,PMID:7646513 NOTES:
is version of: http://identifiers.org/ec-code/1.3.5.1
name: p-cumic alcohol:NAD+ oxidoreductase Glycine, serine and threonine metabolism EC:1.2.1.8
reactant: MODEL1310110063#
kinetic law: MODEL1310110063#
type: Reaction
fast: false
modifier: MODEL1310110063#

http://identifiers.org/biomodels.db/MODEL1310110063#_e94d54f2_265e_4338_b7b4_312ddc11a567
initial concentration: NaN
has only substance units: false
name: PIK3R1
constant: false
type: Species
boundary condition: true
initial amount: NaN
is encoded by: hsa:5295
is: E7EX19
is: SBO:0000252

metaR EX crvnc LPAREN e RPAREN
kinetic law: MODEL1310110063#
reactant: MODEL1310110063#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: nC22:6 exchange
type: Reaction

metaR DM fol
kinetic law: MODEL1310110063#
reactant: MODEL1310110063#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: Demand for folic aicd
type: Reaction

metaR r2327
reversible: true
is described by: ECO:0000000
kinetic law: MODEL1310110063#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
reactant: MODEL1310110063#
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
type: Reaction
fast: false
product: MODEL1310110063#
is: SBO:0000185

metaM CE0693 m
is: HMDB11123
initial concentration: 1.0
name: 3-oxolaur-6-cis-enoyl-CoA
constant: false
initial amount: NaN
has only substance units: false
notes: FORMULA: C33H50N7O18P3S CHARGE: -4 INCHI: InChI=1/C33H54N7O18P3S/c1-4-5-6-7-8-9-10-11-21(41)16-24(43)62-15-14-35-23(42)12-13-36-31(46)28(45)33(2,3)18-55-61(52,53)58-60(50,51)54-17-22-27(57-59(47,48)49)26(44)32(56-22)40-20-39-25-29(34)37-19-38-30(25)40/h8-9,19-20,22,26-28,32,44-45H,4-7,10-18H2,1-3H3,(H,35,42)(H,36,46)(H,50,51)(H,52,53)(H2,34,37,38)(H2,47,48,49)/p-4/b9-8-/t22-,26+,27+,28u,32-/m0/s1 EHMN_ABBREVIATION: CE0693
type: Species
boundary condition: false
is: SBO:0000247
is: CHEBI:28387

metaM dlnlcg c
initial concentration: 1.0
constant: false
has only substance units: false
is: SBO:0000247
type: Species
boundary condition: false
name: dihomo-gamma-linolenic acid (n-6)
is: CHEBI:53486
is: HMDB02925
notes: FORMULA: C20H33O2 CHARGE: -1 INCHI: InChI=1S/C20H34O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20(21)22/h6-7,9-10,12-13H,2-5,8,11,14-19H2,1H3,(H,21,22)/b7-6-,10-9-,13-12-
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110063#_cb85f789_16cd_43f2_9085_73ca7496b231
constant: false
type: Species
has only substance units: false
is encoded by: hsa:4729
name: NDUFV2
initial concentration: NaN
initial amount: NaN
is: P19404
boundary condition: true
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110063#_31d11c86_dbb1_4484_869e_de39efc513e3
boundary condition: true
name: PDE7B
is encoded by: hsa:27115
initial amount: NaN
has only substance units: false
type: Species
initial concentration: NaN
is: Q9NP56
is: SBO:0000252
constant: false

metaM acnacngalgbside hs c
initial concentration: 1.0
constant: false
is: SBO:0000247
is: HMDB00223
is: CHEBI:3338
type: Species
notes: FORMULA: C72H121N4O43FULLRCO CHARGE: -2
has only substance units: false
is: C00036
boundary condition: false
initial amount: NaN
name: disialyl galactosylgloboside

http://identifiers.org/biomodels.db/MODEL1310110063#_ef71266c_40aa_431f_8ea1_c820c1fd4cc7
boundary condition: true
name: PRPS1
has only substance units: false
constant: false
initial concentration: NaN
is: SBO:0000252
type: Species
is: P60891
is encoded by: hsa:5631
initial amount: NaN

metaR DOLP Uter
reactant: MODEL1310110063#
is: SBO:0000176
kinetic law: MODEL1310110063#
fast: false
type: Reaction
reversible: false
notes: GENE_ASSOCIATION: SUBSYSTEM: N-glycan synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:12137737 NOTES:
name: dolichol phosphate flippase (uterus)
is described by: ECO:0000000
product: MODEL1310110063#

http://identifiers.org/biomodels.db/MODEL1310110063#_bbb73c3f_ff6a_4354_80f5_521b50d14b12
boundary condition: true
constant: false
is encoded by: hsa:6535
is: SBO:0000252
initial concentration: NaN
has only substance units: false
type: Species
is: B4DIA3
name: SLC6A8
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110063#_180106af_b41a_418d_aa2c_c6e3de0feac6
has only substance units: false
is: Q8TDY1
is: SBO:0000252
name: B3GALNT1
boundary condition: true
initial amount: NaN
type: Species
is encoded by: hsa:8706
constant: false
initial concentration: NaN

metaR RE0453N
is: SBO:0000176
reactant: MODEL1310110063#
kinetic law: MODEL1310110063#
fast: false
reversible: true
name: RE0453
is version of: http://identifiers.org/ec-code/2.7.4.6
is described by: ECO:0000000
modifier: MODEL1310110063#
product: MODEL1310110063#
notes: GENE_ASSOCIATION: (4830.1) or (4831.1) SUBSYSTEM: Pyrimidine synthesis EC Number: 2.7.4.6 Confidence Level: 0 AUTHORS: PMID:3026468 NOTES:
type: Reaction

metaM abt c
initial amount: NaN
constant: false
boundary condition: false
is: CHEBI:18403
is: SBO:0000247
type: Species
has only substance units: false
initial concentration: 1.0
notes: FORMULA: C5H12O5 CHARGE: 0 INCHI: InChI=1S/C5H12O5/c6-1-3(8)5(10)4(9)2-7/h3-10H,1-2H2/t3-,4-/m0/s1 EHMN_ABBREVIATION: C00532
name: L-arabinitol
is: HMDB01851

metaR DDECE1CRNe
kinetic law: MODEL1310110063#
product: MODEL1310110063#
reactant: MODEL1310110063#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of dodecenoyl carnitine into extra cellular space
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110063#_bf99e309_9683_4a0c_85d7_5f50ca625b14
constant: false
type: Species
is encoded by: hsa:AI684467
initial concentration: NaN
has only substance units: false
boundary condition: true
is: SBO:0000252
name: _AI684467_1_m
initial amount: NaN

metaR NADPHtxu
kinetic law: MODEL1310110063#
reactant: MODEL1310110063#
is described by: ECO:0000000
name: NADPH transporter, peroxisome
reversible: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 1 AUTHORS: PMID:10521434 NOTES:diffusion - unidirectional to avoid NADP/NAD loops w/ free hydrogens NJ
type: Reaction
fast: false
is: SBO:0000185
product: MODEL1310110063#

metaR ORNtiDF
modifier: MODEL1310110063#
product: MODEL1310110063#
notes: GENE_ASSOCIATION: (6542.1) or (6541.1) or (84889.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:11591158,PMID:11891586,PMID:12049641,PMID:1348489,PMID:14770310,PMID:7534987,PMID:8954799 NOTES:SAB
type: Reaction
is: SBO:0000185
kinetic law: MODEL1310110063#
is described by: ECO:0000269
reversible: false
reactant: MODEL1310110063#
fast: false
name: ornithine transport via diffusion (extracellular to cytosol)

metaM hexdicoa r
is: HMDB00672
is: SBO:0000247
name: hexadecanedioylcoa
constant: false
has only substance units: false
type: Species
notes: FORMULA: C37H59N7O19P3S CHARGE: -5
initial concentration: 1.0
initial amount: NaN
boundary condition: false
is: C08260

metaR RE3421R
product: MODEL1310110063#
kinetic law: MODEL1310110063#
name: RE3421
notes: GENE_ASSOCIATION: SUBSYSTEM: Eicosanoid metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:11786541,PMID:8521498 NOTES:
is: SBO:0000176
reversible: true
is described by: ECO:0000000
fast: false
type: Reaction
reactant: MODEL1310110063#

http://identifiers.org/biomodels.db/MODEL1310110063#_a8b4bac6_cd2c_42db_a1ce_0c2de56d2a53
has only substance units: false
name: ACAD9
is: Q9H845
initial concentration: NaN
is: SBO:0000252
boundary condition: true
initial amount: NaN
type: Species
is encoded by: hsa:28976
constant: false

http://identifiers.org/biomodels.db/MODEL1310110063#_b06e67ff_006f_4900_8a27_dd6b311b1e87
type: Species
is: SBO:0000252
initial concentration: NaN
name: BTD
initial amount: NaN
has only substance units: false
is encoded by: hsa:686
constant: false
boundary condition: true
is: P43251

metaM q10 m
initial amount: NaN
name: ubiquinone-10
type: Species
has only substance units: false
is: HMDB01072
is: CHEBI:46245
constant: false
boundary condition: false
notes: FORMULA: C59H90O4 CHARGE: 0 INCHI: InChI=1S/C59H90O4/c1-44(2)24-15-25-45(3)26-16-27-46(4)28-17-29-47(5)30-18-31-48(6)32-19-33-49(7)34-20-35-50(8)36-21-37-51(9)38-22-39-52(10)40-23-41-53(11)42-43-55-54(12)56(60)58(62-13)59(63-14)57(55)61/h24,26,28,30,32,34,36,38,40,42H,15-23,25,27,29,31,33,35,37,39,41,43H2,1-14H3/b45-26+,46-28+,47-30+,48-32+,49-34+,50-36+,51-38+,52-40+,53-42+ HEPATONET_1.0_ABBREVIATION: HC00329 EHMN_ABBREVIATION: C11378
initial concentration: 1.0
is: SBO:0000247

metaR FAOXC225C204m
kinetic law: MODEL1310110063#
product: MODEL1310110063#
reactant: MODEL1310110063#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C22:5-->C20:4)m
type: Reaction

metaR R group phosphotase 2
reversible: false
name: R group phosphotase 2
fast: false
reactant: MODEL1310110063#
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: Confidence Level: AUTHORS: NOTES:
is: SBO:0000176
kinetic law: MODEL1310110063#
product: MODEL1310110063#
type: Reaction
is described by: ECO:0000000

metaR EX 10fthf6glu LPAREN e RPAREN
kinetic law: MODEL1310110063#
reactant: MODEL1310110063#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 10-formyltetrahydrofolate-[Glu](6) exchange
type: Reaction

metaR HPYRR2x
kinetic law: MODEL1310110063#
is version of: http://identifiers.org/ec-code/1.1.1.27
notes: GENE_ASSOCIATION: (3948.1) or (197257.1) or (3945.1) or (160287.1) or (3945.1 and 3939.1) or (92483.1) or (3939.1) or (197257.2) or (3948.2) SUBSYSTEM: Glyoxylate and dicarboxylate metabolism EC Number: 1.1.1.27 Confidence Level: 2 AUTHORS: PMID:14635115,PMID:5635456 NOTES:NCD
is: SBO:0000176
is described by: ECO:0000304
is version of: http://identifiers.org/ec-code/1.1.2.4
modifier: MODEL1310110063#
name: hydroxypyruvate reductase (NADH)
reversible: false
type: Reaction
reactant: MODEL1310110063#
product: MODEL1310110063#
fast: false

metaR EX 5adtststerone LPAREN e RPAREN
kinetic law: MODEL1310110063#
reactant: MODEL1310110063#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 5alpha-Dihydrotestosterone exchange
type: Reaction

metaM udpg r
has only substance units: false
is: HMDB00286
initial concentration: 1.0
type: Species
notes: FORMULA: C15H22N2O17P2 CHARGE: -2 INCHI: InChI=1S/C15H24N2O17P2/c18-3-5-8(20)10(22)12(24)14(32-5)33-36(28,29)34-35(26,27)30-4-6-9(21)11(23)13(31-6)17-2-1-7(19)16-15(17)25/h1-2,5-6,8-14,18,20-24H,3-4H2,(H,26,27)(H,28,29)(H,16,19,25)/p-2/t5-,6-,8-,9-,10+,11-,12-,13-,14?/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00038 EHMN_ABBREVIATION: C00029
is: SBO:0000247
initial amount: NaN
constant: false
boundary condition: false
name: [(2R,3S,4R,5R)-5-(2,4-dioxo-1,2,3,4-tetrahydropyrimidin-1-yl)-3,4-dihydroxyoxolan-2-yl]methyl {[(3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl phosphonato]oxy}phosphonate
is: CHEBI:58367

http://identifiers.org/biomodels.db/MODEL1310110063#_f65761ce_ca1f_4d76_a9be_8a7d03c38e59
has only substance units: false
is encoded by: hsa:3704
type: Species
initial amount: NaN
name: ITPA
boundary condition: true
is: SBO:0000252
is: Q9BY32
constant: false
initial concentration: NaN

metaM ksi pre33 g
name: keratan sulfate I biosynthesis, precursor 33
type: Species
has only substance units: false
constant: false
is: C00130
is: CHEBI:58053
is: HMDB00175
notes: FORMULA: C233H372N16O197S10X CHARGE: -11
boundary condition: false
is: SBO:0000247
initial concentration: 1.0
initial amount: NaN

metaM man g
type: Species
notes: FORMULA: C6H12O6 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00154 EHMN_ABBREVIATION: C00159
boundary condition: false
has only substance units: false
constant: false
name: D-mannose
is: HMDB00169
initial concentration: 1.0
is: CHEBI:16024
is: SBO:0000247
initial amount: NaN

metaM hx2coa m
type: Species
is: http://identifiers.org/pubchem.compound/11966188
boundary condition: false
name: trans-Hex-2-enoyl-CoA
notes: FORMULA: C27H40N7O17P3S CHARGE: -4
is: C05998
initial concentration: 1.0
constant: false
initial amount: NaN
is: SBO:0000247
has only substance units: false
is: HMDB06870

metaM pi c
is: HMDB00973
boundary condition: false
notes: FORMULA: HO4P CHARGE: -2
name: hydrogenphosphate
is: C00009
is: SBO:0000247
is: CHEBI:43474
has only substance units: false
initial concentration: 1.0
type: Species
constant: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110063#_d786690c_da53_4a8d_af8b_b016611e7d39
initial amount: NaN
boundary condition: true
initial concentration: NaN
name: _100128062_1_m
constant: false
type: Species
is: SBO:0000252
is encoded by: hsa:100128062
has only substance units: false

metaM xol7ah2 m
constant: false
notes: FORMULA: C27H48O2 CHARGE: 0 INCHI: InChI=1S/C27H48O2/c1-17(2)7-6-8-18(3)21-9-10-22-25-23(12-14-27(21,22)5)26(4)13-11-20(28)15-19(26)16-24(25)29/h17-25,28-29H,6-16H2,1-5H3/t18-,19+,20-,21-,22+,23+,24-,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01461 EHMN_ABBREVIATION: C05452
type: Species
name: 5beta-cholestane-3alpha,7alpha-diol
initial amount: NaN
is: CHEBI:28047
is: SBO:0000247
initial concentration: 1.0
is: HMDB06893
boundary condition: false
has only substance units: false

metaM ivcrn c
name: isovaleryl carnitine
notes: FORMULA: C12H23NO4 CHARGE: 0
type: Species
boundary condition: false
is: SBO:0000247
is: HMDB00688
initial concentration: 1.0
initial amount: NaN
has only substance units: false
constant: false

metaR CORE4GTg
reversible: false
modifier: MODEL1310110063#
notes: GENE_ASSOCIATION: (9245.1) SUBSYSTEM: O-glycan synthesis EC Number: 2.4.1.148 Confidence Level: 0 AUTHORS: PMID:9915862 NOTES:NCD
is: SBO:0000176
kinetic law: MODEL1310110063#
type: Reaction
is described by: ECO:0000000
name: Core 4 beta6-GalNAc-transferase, Golgi apparatus
is version of: http://identifiers.org/ec-code/2.4.1.102
fast: false
reactant: MODEL1310110063#
product: MODEL1310110063#

metaR GGT5r
kinetic law: MODEL1310110063#
name: Gamma-glutamyltransferase 5
type: Reaction
notes: GENE_ASSOCIATION: (2687.1) SUBSYSTEM: Eicosanoid metabolism EC Number: 2.3.2.2 Confidence Level: 4 AUTHORS: PMID:18357468,PMID:18357469,PMID:6120203 NOTES:Cleaves the gamma-glutamyl peptide bond of glutathione conjugates, but maybe not glutathione itself. Converts leukotriene C4 (LTC4) to leukotriene D4 (LTD4). NJ
reactant: MODEL1310110063#
is version of: http://identifiers.org/ec-code/2.3.2.2
product: MODEL1310110063#
is: SBO:0000176
modifier: MODEL1310110063#
fast: false
reversible: true
is described by: ECO:0000134

metaR GGH 10FTHF6GLUe
modifier: MODEL1310110063#
reversible: false
reactant: MODEL1310110063#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (8836.1) SUBSYSTEM: Folate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:11375437,PMID:2867095,PMID:9614206 NOTES:REMOVES EITHER ONE OR TWO GLUTAMYL RESIDUES WITH A REACTION (WILL ONLY REPRESENT 1) IT
kinetic law: MODEL1310110063#
type: Reaction
name: Gamma-glutamyl hydrolase (10FTHF6GLU), extracellular
fast: false
is version of: http://identifiers.org/ec-code/3.4.19.9
is: SBO:0000176
product: MODEL1310110063#

metaR r0339
reversible: false
is version of: http://identifiers.org/ec-code/2.3.1.65
is: SBO:0000176
name: ATP:(R)-glycerate 3-phosphotransferase Glycine, serine and threonine metabolism EC:2.7.1.31
notes: GENE_ASSOCIATION: (10965.1) or (122970.1) or (11332.1) or (570.1) or (80864.1) or (83715.1) or (5538.1) or (9374.1) or (R33828.1) SUBSYSTEM: Unassigned EC Number: 2.7.1.31 Confidence Level: 0 AUTHORS: PMID:16753811,PMID:216417,PMID:2537226,PMID:6252205 NOTES:
is version of: http://identifiers.org/ec-code/3.1.2.2
is described by: ECO:0000000
kinetic law: MODEL1310110063#
type: Reaction
reactant: MODEL1310110063#
product: MODEL1310110063#
is version of: http://identifiers.org/ec-code/3.1.2.22
fast: false
modifier: MODEL1310110063#

http://identifiers.org/biomodels.db/MODEL1310110063#_beff3e97_7220_4149_a4b4_ea77de107653
constant: false
initial concentration: NaN
is encoded by: hsa:NM 001929
type: Species
boundary condition: true
has only substance units: false
is: SBO:0000252
initial amount: NaN
name: _NM_001929_1_c

metaR FAOXC260240x
modifier: MODEL1310110063#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.3.1.16
notes: GENE_ASSOCIATION: (3295.1 and 30.1 and 51.2) or (51.1 and 30.1 and 1962.1) or (51.1 and 3295.1 and 30.1) or (30.1 and 51.2 and 1962.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.74 Confidence Level: 4 AUTHORS: NOTES:peroxisomal (very long chain FA) - in peroxisome, no fad, 1ste set of beta-ox is by acyl-coa oxidase (passes electrons directly to o2 -> h2o2) c26:0 -> c24:0 4 step FAO lumped also includes EC 1.1.1.35, 1.1.1.211, 1.3.3.6, 4.2.1.17, 4.2.1.74 -> into pmtcoa NJ
product: MODEL1310110063#
reactant: MODEL1310110063#
reversible: false
is version of: http://identifiers.org/ec-code/4.2.1.107
is described by: ECO:0000000
kinetic law: MODEL1310110063#
name: Beta oxidation of long chain fatty acid
type: Reaction
is version of: http://identifiers.org/ec-code/1.3.3.6
fast: false
is version of: http://identifiers.org/ec-code/1.1.1.35

metaM HC01410 m
initial amount: NaN
constant: false
type: Species
name: (2E)-Hexenoyl-CoA
initial concentration: 1.0
is: CHEBI:28706
notes: FORMULA: C27H40N7O17P3S CHARGE: -4 INCHI: InChI=1S/C27H44N7O17P3S/c1-4-5-6-7-18(36)55-11-10-29-17(35)8-9-30-25(39)22(38)27(2,3)13-48-54(45,46)51-53(43,44)47-12-16-21(50-52(40,41)42)20(37)26(49-16)34-15-33-19-23(28)31-14-32-24(19)34/h6-7,14-16,20-22,26,37-38H,4-5,8-13H2,1-3H3,(H,29,35)(H,30,39)(H,43,44)(H,45,46)(H2,28,31,32)(H2,40,41,42)/b7-6+/t16-,20-,21-,22+,26-/m1/s1 EHMN_ABBREVIATION: C05271
boundary condition: false
is: SBO:0000247
has only substance units: false

metaM occoa x
name: Octanoyl-CoA (n-C8:0CoA)
initial concentration: 1.0
initial amount: NaN
is: SBO:0000247
constant: false
notes: FORMULA: C29H46N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00869 EHMN_ABBREVIATION: C01944
has only substance units: false
boundary condition: false
is: CHEBI:57386
type: Species
is: HMDB01070
is: C01944

metaR 2OXOADOXm
modifier: MODEL1310110063#
is version of: http://identifiers.org/ec-code/1.2.4.2
name: 2-Oxoadipate:lipoamde 2-oxidoreductase(decarboxylating and acceptor-succinylating) (mitochondria)
fast: false
is described by: ECO:0000304
product: MODEL1310110063#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.8.1.4
kinetic law: MODEL1310110063#
reversible: false
type: Reaction
is version of: http://identifiers.org/ec-code/2.3.1.61
reactant: MODEL1310110063#
notes: GENE_ASSOCIATION: (4967.1) and (1738.1 and 8050.1) and (1743.1) or (4967.2) and (1738.1 and 8050.1) and (1743.1) SUBSYSTEM: Lysine metabolism EC Number: 2.3.1.61 Confidence Level: 2 AUTHORS: NOTES:SAB

http://identifiers.org/biomodels.db/MODEL1310110063#_7bf18726_eb4a_4e1b_b46a_8a379bee6eb4
initial amount: NaN
type: Species
has only substance units: false
name: SLC6A10P
initial concentration: NaN
is: SBO:0000252
boundary condition: true
is encoded by: hsa:386757
constant: false

metaM elaid e
has only substance units: false
initial concentration: 1.0
is: CHEBI:30825
type: Species
name: elaidate
boundary condition: false
notes: FORMULA: C18H33O2 CHARGE: -1 INCHI: InChI=1S/C18H34O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20/h9-10H,2-8,11-17H2,1H3,(H,19,20)/p-1/b10-9+ HEPATONET_1.0_ABBREVIATION: HC00830
initial amount: NaN
constant: false
is: HMDB00573
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110063#_16edd9af_5f9b_4fc2_a8a3_a55a42506f8f
type: Species
is encoded by: hsa:954
has only substance units: false
initial concentration: NaN
boundary condition: true
is: SBO:0000252
initial amount: NaN
is: Q5SPY7
name: ENTPD2
constant: false

metaR KSItly
name: keratan sulfate I transport, extracellular to lysosome
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 2 AUTHORS: NOTES:NCD
reversible: false
type: Reaction
fast: false
is described by: ECO:0000000
kinetic law: MODEL1310110063#
product: MODEL1310110063#
is: SBO:0000185
reactant: MODEL1310110063#

metaM cholcoaone x
is: HMDB06891
name: 3alpha,7alpha,12alpha-trihydroxy-24-oxo-5beta-cholestan-26-oyl-CoA(4-)
initial amount: NaN
notes: FORMULA: C48H74N7O21P3S CHARGE: -4 INCHI: InChI=1S/C48H78N7O21P3S/c1-24(28-8-9-29-36-30(19-34(59)48(28,29)6)47(5)13-11-27(56)17-26(47)18-32(36)58)7-10-31(57)25(2)45(64)80-16-15-50-35(60)12-14-51-43(63)40(62)46(3,4)21-73-79(70,71)76-78(68,69)72-20-33-39(75-77(65,66)67)38(61)44(74-33)55-23-54-37-41(49)52-22-53-42(37)55/h22-30,32-34,36,38-40,44,56,58-59,61-62H,7-21H2,1-6H3,(H,50,60)(H,51,63)(H,68,69)(H,70,71)(H2,49,52,53)(H2,65,66,67)/p-4/t24-,25?,26+,27-,28-,29+,30+,32-,33-,34+,36+,38-,39-,40+,44-,47+,48-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01473 EHMN_ABBREVIATION: C05467
type: Species
has only substance units: false
boundary condition: false
is: CHEBI:58507
constant: false
initial concentration: 1.0
is: SBO:0000247

metaR EX 9 cis retfa LPAREN e RPAREN
kinetic law: MODEL1310110063#
reactant: MODEL1310110063#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: fatty acid 9-cis-retinol exchange
type: Reaction

metaM l2fn2m2masn g
constant: false
has only substance units: false
is: CHEBI:28067
name: {[galactosyl-(1,4)-N-Acetyl-glucosaminyl-(1,2)-mannosyl-(1,3)-],[N-acetyl-glucosaminyl-(1,2)-mannosyl-(1,6)-]mannosyl-(1,4)-N-acetyl-glucosaminyl-(1,4)-[fucosyl-(1,6)]-N-acetyl-glucosaminyl}asparagine
initial concentration: 1.0
type: Species
notes: FORMULA: C68H113N4O49X CHARGE: 0
is: SBO:0000247
initial amount: NaN
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110063#_634724ac_b23d_4d16_add6_2ea759b18ccd
has only substance units: false
type: Species
is: SBO:0000252
name: PIP5K1C
is: O60331
boundary condition: true
constant: false
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:23396

http://identifiers.org/biomodels.db/MODEL1310110063#_143e6cd9_3845_4595_9433_79661786975c
name: SLC27A2
is: SBO:0000252
constant: false
initial amount: NaN
type: Species
boundary condition: true
is: O14975
initial concentration: NaN
is encoded by: hsa:11001
has only substance units: false

metaM hs deg16 l
constant: false
initial concentration: 1.0
is: CHEBI:21338
initial amount: NaN
name: heparan sulfate, degradation product 16
type: Species
notes: FORMULA: C49H72N2O54S4 CHARGE: -6
is: HMDB02704
boundary condition: false
is: SBO:0000247
has only substance units: false

metaM pi e
notes: FORMULA: HO4P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00019 EHMN_ABBREVIATION: C00009
name: hydrogenphosphate
constant: false
type: Species
is: HMDB00973
has only substance units: false
is: CHEBI:43474
initial amount: NaN
is: C00009
is: SBO:0000247
boundary condition: false
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110063#_3f5a1715_69ee_4cfd_b589_66a1f8571bc4
initial amount: NaN
constant: false
is encoded by: hsa:23428
initial concentration: NaN
boundary condition: true
is: SBO:0000252
has only substance units: false
name: SLC7A8
is: Q86U05
type: Species

metaR RE0926E
modifier: MODEL1310110063#
name: RE0926
product: MODEL1310110063#
is: SBO:0000176
reactant: MODEL1310110063#
reversible: true
fast: false
kinetic law: MODEL1310110063#
type: Reaction
notes: GENE_ASSOCIATION: (276.1) or (277.1) or (278.1) or (279.1) or (276.1) or (277.1) or (278.1) or (279.1) or (280.1) or (84569.1) SUBSYSTEM: Starch and sucrose metabolism EC Number: 3.2.1.1 Confidence Level: 0 AUTHORS: PMID:385176,PMID:8528071,PMID:890964 NOTES:
is version of: http://identifiers.org/ec-code/3.2.1.1
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/3.2.1.17

http://identifiers.org/biomodels.db/MODEL1310110063#_a2a644a9_9f0f_48e0_ae46_57a165f454c4
is: SBO:0000252
constant: false
type: Species
boundary condition: true
is encoded by: hsa:6241
is: P31350
name: RRM2
initial concentration: NaN
has only substance units: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110063#_f574eeec_afb5_4000_833e_1ff0f6b72a02
is: SBO:0000252
is: P24310
is encoded by: hsa:1346
initial concentration: NaN
initial amount: NaN
has only substance units: false
constant: false
name: COX7A1
boundary condition: true
type: Species

http://identifiers.org/biomodels.db/MODEL1310110063#_8f7b9008_76bf_41ad_adcc_8b055fcfef73
initial concentration: NaN
is: SBO:0000252
has only substance units: false
is: Q06203
initial amount: NaN
type: Species
name: PPAT
is encoded by: hsa:5471
constant: false
boundary condition: true

metaM 2mpdhl m
type: Species
constant: false
initial amount: NaN
has only substance units: false
boundary condition: false
name: S-(2-Methylpropanoyl)-dihydrolipoamide
is: SBO:0000247
notes: FORMULA: C12H23NO2S2 CHARGE: 0 INCHI: InChI=1S/C12H23NO2S2/c1-9(2)12(15)17-8-7-10(16)5-3-4-6-11(13)14/h9-10,16H,3-8H2,1-2H3,(H2,13,14) EHMN_ABBREVIATION: C04424
initial concentration: 1.0
is: CHEBI:17577

metaM g3m8masn r
has only substance units: false
initial concentration: 1.0
notes: FORMULA: C88H147N2O70X CHARGE: 0
constant: false
is: C05873
boundary condition: false
name: (alpha-D-Glucosyl)3-(alpha-D-mannosyl)8-beta-D-mannosyl-diacetylchitobiosyl-L-asparagine (protein)
is: SBO:0000247
type: Species
initial amount: NaN

metaM h x
boundary condition: false
is: http://identifiers.org/pubchem.compound/3380
is: SBO:0000247
type: Species
initial amount: NaN
notes: FORMULA: H CHARGE: 1 INCHI: " HEPATONET_1.0_ABBREVIATION: HC00083 EHMN_ABBREVIATION: C00080
name: proton
constant: false
initial concentration: 1.0
is: C00080
has only substance units: false
is: CHEBI:24636

metaM 2decdicoa x
boundary condition: false
is: SBO:0000247
is: http://identifiers.org/pubchem.compound/16019966
constant: false
has only substance units: false
notes: FORMULA: C31H46N7O17P3S CHARGE: -4
name: 2,7-decadienoylcoa
type: Species
initial amount: NaN
initial concentration: 1.0

metaR HOCTDACBP
kinetic law: MODEL1310110063#
product: MODEL1310110063#
reactant: MODEL1310110063#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: transport of 3-hydroxyoctadecenoylcoa from mitochondria into the cytosol
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110063#_0617dd95_d62f_4fd1_975f_162f73c382eb
initial amount: NaN
has only substance units: false
type: Species
is: O14732
is: SBO:0000252
boundary condition: true
name: IMPA2
initial concentration: NaN
is encoded by: hsa:3613
constant: false

metaM hpdcacrn c
is: HMDB06210
initial concentration: 1.0
is: SBO:0000247
constant: false
boundary condition: false
notes: FORMULA: C24H47NO4 CHARGE: 0 INCHI: InChI=1/C24H47NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-24(28)29-22(20-23(26)27)21-25(2,3)4/h22H,5-21H2,1-4H3
initial amount: NaN
type: Species
name: heptadecanoyl carnitine
has only substance units: false

metaM core4 g
is: SBO:0000247
initial amount: NaN
has only substance units: false
initial concentration: 1.0
notes: FORMULA: C24H40N3O15X CHARGE: 0
is: CHEBI:16478
name: Core 4
boundary condition: false
constant: false
type: Species

metaM arg L c
initial concentration: 1.0
has only substance units: false
type: Species
boundary condition: false
is: HMDB00517
name: L-argininium(1+)
is: SBO:0000247
notes: FORMULA: C6H15N4O2 CHARGE: 1 INCHI: InChI=1S/C6H14N4O2/c7-4(5(11)12)2-1-3-10-6(8)9/h4H,1-3,7H2,(H,11,12)(H4,8,9,10)/p+1/t4-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00065
constant: false
is: CHEBI:32682
initial amount: NaN

metaR D3AIBTm
product: MODEL1310110063#
reactant: MODEL1310110063#
type: Reaction
name: D-3-Amino-isobutanoate:pyruvate aminotransferase, mitochondrial
kinetic law: MODEL1310110063#
reversible: true
fast: false
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Pyrimidine catabolism EC Number: 2.6.1.40 Confidence Level: 4 AUTHORS: PMID:5773299 NOTES:MM
is: SBO:0000176

metaR r2320
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
type: Reaction
reactant: MODEL1310110063#
is described by: ECO:0000000
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
fast: false
is: SBO:0000185
product: MODEL1310110063#
kinetic law: MODEL1310110063#
reversible: true

metaM mlthf m
constant: false
boundary condition: false
is: SBO:0000247
initial amount: NaN
has only substance units: false
notes: FORMULA: C20H21N7O6 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00140 EHMN_ABBREVIATION: C00143
name: 5,10-Methylenetetrahydrofolate
initial concentration: 1.0
is: C00143
type: Species
is: HMDB01533
is: CHEBI:15636

metaM ksi pre1 g
boundary condition: false
is: SBO:0000247
initial amount: NaN
is: CHEBI:58053
initial concentration: 1.0
is: HMDB00175
has only substance units: false
is: C00130
name: keratan sulfate I biosynthesis, precursor 1
constant: false
notes: FORMULA: C79H129N5O57X CHARGE: -1
type: Species

metaM hco3 m
type: Species
initial concentration: 1.0
initial amount: NaN
has only substance units: false
is: C00288
notes: FORMULA: CHO3 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00253 EHMN_ABBREVIATION: C00288
is: CHEBI:17544
is: HMDB00595
is: SBO:0000247
boundary condition: false
name: Bicarbonate
constant: false

metaM 5HPET c
is: CHEBI:57450
initial amount: NaN
constant: false
notes: FORMULA: C20H31O4 CHARGE: -1 INCHI: InChI=1S/C20H32O4/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-16-19(24-23)17-15-18-20(21)22/h6-7,9-10,12-14,16,19,23H,2-5,8,11,15,17-18H2,1H3,(H,21,22)/p-1/b7-6-,10-9-,13-12-,16-14+/t19-/m1/s1
initial concentration: 1.0
boundary condition: false
is: HMDB01193
has only substance units: false
type: Species
is: SBO:0000247
name: 5(S)-HPETE(1-)

metaM CE4795 x
notes: FORMULA: C41H60N7O17P3S CHARGE: -4 INCHI: InChI=1/C41H64N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-32(50)69-25-24-43-31(49)22-23-44-39(53)36(52)41(2,3)27-62-68(59,60)65-67(57,58)61-26-30-35(64-66(54,55)56)34(51)40(63-30)48-29-47-33-37(42)45-28-46-38(33)48/h8-9,11-12,14-15,18-21,28-30,34-36,40,51-52H,4-7,10,13,16-17,22-27H2,1-3H3,(H,43,49)(H,44,53)(H,57,58)(H,59,60)(H2,42,45,46)(H2,54,55,56)/p-4/b9-8-,12-11-,15-14-,19-18-,21-20+/t30-,34+,35+,36u,40-/m0/s1 EHMN_ABBREVIATION: CE4795
is: SBO:0000247
initial concentration: 1.0
constant: false
name: 2-trans-cis,cis,cis,cis-4,8,11,14-eicosapentaenoyl-CoA
is: CHEBI:57923
type: Species
boundary condition: false
initial amount: NaN
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110063#_b8cbda8f_beb4_4843_8c2b_1d0947b009e7
boundary condition: true
is: F8W7V3
initial concentration: NaN
constant: false
type: Species
initial amount: NaN
is encoded by: hsa:9551
name: ATP5J2
has only substance units: false
is: SBO:0000252

metaR r0660
notes: GENE_ASSOCIATION: (10637.1) or (5831.1) or (29920.1) or (65263.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.17 Confidence Level: 0 AUTHORS: PMID:8012501,PMID:8188243 NOTES:
is: SBO:0000176
name: (S)-3-Hydroxydodecanoyl-CoA hydro-lyase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:4.2.1.17
reactant: MODEL1310110063#
is version of: http://identifiers.org/ec-code/1.5.1.2
reversible: true
product: MODEL1310110063#
kinetic law: MODEL1310110063#
type: Reaction
modifier: MODEL1310110063#
is described by: ECO:0000000
fast: false

metaR H3MTer U
fast: false
type: Reaction
kinetic law: MODEL1310110063#
modifier: MODEL1310110063#
reactant: MODEL1310110063#
is described by: ECO:0000000
is: SBO:0000176
product: MODEL1310110063#
notes: GENE_ASSOCIATION: (9488.1) SUBSYSTEM: Phosphatidylinositol phosphate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:8861954 NOTES:NCD
reversible: false
name: H3 mannosyltransferase, endoplasmic reticulum

http://identifiers.org/biomodels.db/MODEL1310110063#_b487b868_2f1c_4b01_9fb0_45785576e6e8
name: SLC4A8
is: E7EML0
has only substance units: false
initial amount: NaN
is: SBO:0000252
type: Species
constant: false
initial concentration: NaN
boundary condition: true
is encoded by: hsa:9498

http://identifiers.org/biomodels.db/MODEL1310110063#_86fa2e5a_a8dd_4859_81bf_108eb23e5c7a
type: Species
is: SBO:0000252
is encoded by: hsa:4714
initial amount: NaN
boundary condition: true
initial concentration: NaN
constant: false
name: NDUFB8
is: O95169
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110063#_3406fa53_087e_4e55_8bbb_174454aec515
is: Q15111
is encoded by: hsa:5334
name: PLCL1
is: SBO:0000252
type: Species
has only substance units: false
initial concentration: NaN
constant: false
initial amount: NaN
boundary condition: true

metaR NICRNS
fast: false
name: NICRNS
reversible: false
type: Reaction
is described by: ECO:0000000
is: SBO:0000176
kinetic law: MODEL1310110063#
reactant: MODEL1310110063#
product: MODEL1310110063#
notes: GENE_ASSOCIATION: SUBSYSTEM: NAD metabolism EC Number: Confidence Level: 2 AUTHORS: NOTES:no gene or enzyme name known (in kegg) but reaction has to take place. IT

metaR C60CPT1
kinetic law: MODEL1310110063#
product: MODEL1310110063#
reactant: MODEL1310110063#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: production of hexanoylcarnitine
type: Reaction

metaR r0881
is: SBO:0000185
product: MODEL1310110063#
fast: false
name: Active transport
kinetic law: MODEL1310110063#
reactant: MODEL1310110063#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12107270,PMID:12739169,PMID:12829793,PMID:17245649,PMID:18375207,PMID:8476015,PMID:8557697,PMID:9786900 NOTES:
type: Reaction
reversible: false

metaR PAPtg
is: SBO:0000185
reactant: MODEL1310110063#
type: Reaction
product: MODEL1310110063#
fast: false
kinetic law: MODEL1310110063#
is described by: ECO:0000000
name: adenosine 3',5'-bisphosphate Golgi transport
reversible: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD

metaM HC02187 c
constant: false
type: Species
initial amount: NaN
is: CHEBI:28774
is: SBO:0000247
boundary condition: false
has only substance units: false
initial concentration: 1.0
name: reverse-triiodthyronine
notes: FORMULA: C15H12I3NO4 CHARGE: 0 INCHI: InChI=1S/C15H12I3NO4/c16-9-3-7(4-12(19)15(21)22)1-2-13(9)23-8-5-10(17)14(20)11(18)6-8/h1-3,5-6,12,20H,4,19H2,(H,21,22)

http://identifiers.org/biomodels.db/MODEL1310110063#_89fc5b1a_691d_4f44_8496_152e1dc2109c
initial concentration: NaN
is: Q86SF2
is encoded by: hsa:51809
name: GALNT7
type: Species
is: SBO:0000252
boundary condition: true
initial amount: NaN
has only substance units: false
constant: false

metaM ksi deg23 l
type: Species
notes: FORMULA: C124H201N8O106S5 CHARGE: -5
is: CHEBI:12936
initial concentration: 1.0
name: keratan sulfate I, degradation product 23
boundary condition: false
is: HMDB00143
constant: false
has only substance units: false
is: SBO:0000247
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110063#_659026b8_610f_4227_8168_8ee7347bd47b
boundary condition: true
is: SBO:0000252
type: Species
initial amount: NaN
name: ACSL3
has only substance units: false
constant: false
initial concentration: NaN
is encoded by: hsa:2181
is: B3KMA6

metaR RE1903R
reactant: MODEL1310110063#
product: MODEL1310110063#
kinetic law: MODEL1310110063#
fast: false
is described by: ECO:0000000
is: SBO:0000176
name: RE1903
notes: GENE_ASSOCIATION: SUBSYSTEM: Vitamin A metabolism EC Number: 1.2.1.36 Confidence Level: 0 AUTHORS: PMID:10559215,PMID:11007799 NOTES:
reversible: true
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110063#_d7e78e7a_dc31_4ca9_8846_f1eda4cceaf6
name: _W74642_1_c
type: Species
constant: false
is: SBO:0000252
is encoded by: hsa:W74642
initial concentration: NaN
initial amount: NaN
has only substance units: false
boundary condition: true

metaM etfrd m
has only substance units: false
is: HMDB00145
notes: FORMULA: RH2 CHARGE: 0
initial concentration: 1.0
constant: false
is: SBO:0000247
initial amount: NaN
is: CHEBI:17263
boundary condition: false
name: Electron transfer flavoprotein reduced
type: Species

metaM 3hodcoa c
constant: false
name: (S)-3-Hydroxyoctadecanoyl-CoA
boundary condition: false
type: Species
is: HMDB13336
has only substance units: false
initial concentration: 1.0
initial amount: NaN
is: SBO:0000247
notes: FORMULA: C39H66N7O18P3S CHARGE: -4

metaR PCHOLPm hs
name: choline phosphatase
fast: false
kinetic law: MODEL1310110063#
is described by: ECO:0000269
reactant: MODEL1310110063#
product: MODEL1310110063#
type: Reaction
reversible: false
modifier: MODEL1310110063#
is: SBO:0000176
notes: GENE_ASSOCIATION: (5337.1) SUBSYSTEM: Glycerophospholipid metabolism EC Number: 3.1.4.4 Confidence Level: 4 AUTHORS: PMID:11481335,PMID:8530346 NOTES:NJ
is version of: http://identifiers.org/ec-code/3.1.4.4

metaR ADRNCOAtx
is: SBO:0000185
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: NOTES:interaction between peroxisomes and ER (some enzymes on the outer membrane) NJ
type: Reaction
kinetic law: MODEL1310110063#
reversible: true
fast: false
reactant: MODEL1310110063#
product: MODEL1310110063#
name: fatty acid intracellular transport

metaM ksi pre31 g
is: HMDB00175
name: keratan sulfate I biosynthesis, precursor 31
is: C00130
boundary condition: false
is: CHEBI:58053
is: SBO:0000247
type: Species
has only substance units: false
constant: false
notes: FORMULA: C227H363N16O189S9X CHARGE: -10
initial concentration: 1.0
initial amount: NaN

metaR r2321
is: SBO:0000185
product: MODEL1310110063#
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
is described by: ECO:0000000
reversible: true
reactant: MODEL1310110063#
fast: false
type: Reaction
kinetic law: MODEL1310110063#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110063#_1577f61e_6e70_430e_9d2e_5b5987fa3058
has only substance units: false
boundary condition: true
is: Q6P1M0
initial concentration: NaN
is: SBO:0000252
type: Species
constant: false
name: SLC27A4
is encoded by: hsa:10999
initial amount: NaN

metaM man c
is: HMDB00169
is: CHEBI:16024
initial concentration: 1.0
notes: FORMULA: C6H12O6 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00154 EHMN_ABBREVIATION: C00159
name: D-Mannose
has only substance units: false
type: Species
constant: false
boundary condition: false
is: C00159
initial amount: NaN
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110063#_a2d29a77_f12f_44eb_a1cd_14dd8d2885e0
is: P06576
constant: false
type: Species
is encoded by: hsa:506
has only substance units: false
name: ATP5B
initial concentration: NaN
initial amount: NaN
is: SBO:0000252
boundary condition: true

metaR FAOXC11
is described by: ECO:0000000
fast: false
is version of: http://identifiers.org/ec-code/1.3.99.3
type: Reaction
name: Beta oxidation of long chain fatty acid
notes: GENE_ASSOCIATION: (34.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.99.3 Confidence Level: 2 AUTHORS: PMID:9819701 NOTES:TV Other enzymes: 1.3.3.6, 4.2.1.74, 4.2.1.17, 1.1.1.35, 1.1.1.211 1 round of beta ox of branched chain FA from peroxisome NJ
modifier: MODEL1310110063#
product: MODEL1310110063#
kinetic law: MODEL1310110063#
reactant: MODEL1310110063#
is: SBO:0000176
reversible: false

metaM arg L e
is: HMDB00517
initial concentration: 1.0
type: Species
is: SBO:0000247
has only substance units: false
boundary condition: false
name: L-argininium(1+)
constant: false
notes: FORMULA: C6H15N4O2 CHARGE: 1 INCHI: InChI=1S/C6H14N4O2/c7-4(5(11)12)2-1-3-10-6(8)9/h4H,1-3,7H2,(H,11,12)(H4,8,9,10)/p+1/t4-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00065
initial amount: NaN
is: CHEBI:32682

http://identifiers.org/biomodels.db/MODEL1310110063#_e44c9449_3746_435e_9c1b_c418be651298
initial concentration: NaN
type: Species
is encoded by: hsa:10423
initial amount: NaN
constant: false
is: SBO:0000252
has only substance units: false
name: CDIPT
boundary condition: true
is: A8K3L7

metaR FAOXC4C4DCc
kinetic law: MODEL1310110063#
product: MODEL1310110063#
reactant: MODEL1310110063#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: succ-->C4DCc
type: Reaction

metaM abt e
is: SBO:0000247
boundary condition: false
name: L-arabinitol
is: HMDB01851
initial amount: NaN
constant: false
type: Species
has only substance units: false
notes: FORMULA: C5H12O5 CHARGE: 0 INCHI: InChI=1S/C5H12O5/c6-1-3(8)5(10)4(9)2-7/h3-10H,1-2H2/t3-,4-/m0/s1 EHMN_ABBREVIATION: C00532
initial concentration: 1.0
is: CHEBI:18403

metaM 3hddcoa c
type: Species
initial concentration: 1.0
is: HMDB03712
initial amount: NaN
name: (S)-3-Hydroxydodecanoyl-CoA
constant: false
boundary condition: false
notes: FORMULA: C33H54N7O18P3S CHARGE: -4
has only substance units: false
is: SBO:0000247

metaM hexdicoa c
notes: FORMULA: C37H59N7O19P3S CHARGE: -5
name: hexadecanedioylcoa
initial concentration: 1.0
initial amount: NaN
has only substance units: false
is: HMDB02014
constant: false
boundary condition: false
type: Species
is: SBO:0000247

metaM ptth c
is: HMDB03426
notes: FORMULA: C11H22N2O4S CHARGE: 0 INCHI: InChI=1S/C11H22N2O4S/c1-11(2,7-14)9(16)10(17)13-4-3-8(15)12-5-6-18/h9,14,16,18H,3-7H2,1-2H3,(H,12,15)(H,13,17)/t9-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00554 EHMN_ABBREVIATION: C00831
is: CHEBI:16753
constant: false
initial amount: NaN
boundary condition: false
type: Species
has only substance units: false
initial concentration: 1.0
name: pantetheine
is: SBO:0000247

metaM dhcholoylcoa x
is: HMDB06895
type: Species
is: SBO:0000247
constant: false
name: 3alpha,7alpha-Dihydroxy-5beta-cholest-24-enoyl-CoA
notes: FORMULA: C48H74N7O19P3S CHARGE: -4 INCHI: InChI=1S/C48H78N7O19P3S/c1-26(30-10-11-31-36-32(13-16-48(30,31)6)47(5)15-12-29(56)20-28(47)21-33(36)57)8-7-9-27(2)45(62)78-19-18-50-35(58)14-17-51-43(61)40(60)46(3,4)23-71-77(68,69)74-76(66,67)70-22-34-39(73-75(63,64)65)38(59)44(72-34)55-25-54-37-41(49)52-24-53-42(37)55/h9,24-26,28-34,36,38-40,44,56-57,59-60H,7-8,10-23H2,1-6H3,(H,50,58)(H,51,61)(H,66,67)(H,68,69)(H2,49,52,53)(H2,63,64,65)/t26-,28+,29-,30-,31+,32+,33-,34-,36+,38-,39-,40+,44-,47+,48-/m1/s1
is: CHEBI:27393
boundary condition: false
initial amount: NaN
initial concentration: 1.0
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110063#_1c17b85f_8fd1_48df_89c6_a6db8c21d6ea
is encoded by: hsa:3034
constant: false
name: HAL
boundary condition: true
is: B4E0V8
initial concentration: NaN
is: SBO:0000252
initial amount: NaN
type: Species
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110063#_a3afd436_2403_4bb6_bcdf_902a82c8b442
initial amount: NaN
is encoded by: hsa:1607
constant: false
boundary condition: true
type: Species
is: SBO:0000252
initial concentration: NaN
has only substance units: false
name: DGKB

metaM pail345p hs c
is: SBO:0000247
type: Species
name: 1-phosphatidyl-1D-myo-inositol 3,4,5-trisphosphate(7-)
constant: false
is: CHEBI:57836
has only substance units: false
boundary condition: false
initial concentration: 1.0
notes: FORMULA: C9H13O18P4FULLRCO2FULLR2CO2 CHARGE: -7 EHMN_ABBREVIATION: C05981
initial amount: NaN

metaM xol7a r
is: HMDB01496
constant: false
type: Species
initial concentration: 1.0
boundary condition: false
name: 20-hydroxycholesterol
is: CHEBI:1296
has only substance units: false
notes: FORMULA: C27H46O2 CHARGE: 0 INCHI: InChI=1S/C27H46O2/c1-18(2)7-6-14-27(5,29)24-11-10-22-21-9-8-19-17-20(28)12-15-25(19,3)23(21)13-16-26(22,24)4/h8,18,20-24,28-29H,6-7,9-17H2,1-5H3/t20-,21-,22-,23-,24-,25-,26-,27-/m0/s1 EHMN_ABBREVIATION: C03594
is: SBO:0000247
initial amount: NaN

metaR KYNATESYN
type: Reaction
reversible: false
product: MODEL1310110063#
name: 4-(2-Aminophenyl)-2,4-dioxobutanoate dehydratase
kinetic law: MODEL1310110063#
fast: false
reactant: MODEL1310110063#
is described by: ECO:0000000
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Tryptophan metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:15016471,PMID:16008534 NOTES:SAB name is a guess

metaR PALFATPtc
kinetic law: MODEL1310110063#
product: MODEL1310110063#
reactant: MODEL1310110063#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: uptake of Hexadecanoate by the enterocytes
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110063#_6ee3fd6e_a472_406c_b2c3_be3e7b9c2aad
name: INPP5D
has only substance units: false
is encoded by: hsa:3635
constant: false
is: SBO:0000252
is: Q92835
initial amount: NaN
initial concentration: NaN
type: Species
boundary condition: true

metaM HC02187 e
initial amount: NaN
type: Species
is: SBO:0000247
is: CHEBI:28774
boundary condition: false
constant: false
initial concentration: 1.0
notes: FORMULA: C15H12I3NO4 CHARGE: 0 INCHI: InChI=1S/C15H12I3NO4/c16-9-3-7(4-12(19)15(21)22)1-2-13(9)23-8-5-10(17)14(20)11(18)6-8/h1-3,5-6,12,20H,4,19H2,(H,21,22)
name: reverse-triiodthyronine
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110063#_0463d3e4_e620_495f_b2c2_23109f7cc987
has only substance units: false
type: Species
initial amount: NaN
constant: false
is encoded by: hsa:514
initial concentration: NaN
is: SBO:0000252
boundary condition: true
name: ATP5E

http://identifiers.org/biomodels.db/MODEL1310110063#_cfcbec4d_1089_40b7_bd8b_946957d761db
type: Species
boundary condition: true
constant: false
is: SBO:0000252
initial amount: NaN
initial concentration: NaN
has only substance units: false
is encoded by: hsa:9091
is: Q9BRB3
name: PIGQ

metaM ksii core2 deg5 l
initial concentration: 1.0
type: Species
is: SBO:0000247
has only substance units: false
is: CHEBI:12936
notes: FORMULA: C50H82N4O38SX CHARGE: -1
is: HMDB00143
name: keratan sulfate II (core 2-linked), degradation product 5
initial amount: NaN
constant: false
boundary condition: false

metaM sphs1p e
initial concentration: 1.0
notes: FORMULA: C18H37NO5P CHARGE: -1 INCHI: InChI=1S/C18H38NO5P/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-18(20)17(19)16-24-25(21,22)23/h14-15,17-18,20H,2-13,16,19H2,1H3,(H2,21,22,23)/p-1/b15-14+/t17-,18+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01702 EHMN_ABBREVIATION: C06124
is: HMDB00277
boundary condition: false
constant: false
is: SBO:0000247
is: CHEBI:60119
type: Species
initial amount: NaN
has only substance units: false
name: sphingosine 1-phosphate(1-)

http://identifiers.org/biomodels.db/MODEL1310110063#_d03278f8_2022_4ed5_8211_09ec07154e82
boundary condition: true
is encoded by: hsa:84890
initial concentration: NaN
is: SBO:0000252
is: B3KXN9
has only substance units: false
type: Species
initial amount: NaN
name: ADO
constant: false

http://identifiers.org/biomodels.db/MODEL1310110063#_60fc6115_574c_4d54_ab5a_406dc62ca911
is encoded by: hsa:81579
is: Q542Y6
type: Species
has only substance units: false
constant: false
name: PLA2G12A
boundary condition: true
is: SBO:0000252
initial amount: NaN
initial concentration: NaN

metaM m7masnB r
notes: FORMULA: C64H107N2O50X CHARGE: 0
initial concentration: 1.0
type: Species
initial amount: NaN
name: (alpha-D-mannosyl)7-beta-D-mannosyl-diacetylchitobiosyl-L-asparagine, isoform B (protein)
has only substance units: false
boundary condition: false
is: SBO:0000247
constant: false
is: C05881

metaR FAOXC184m
kinetic law: MODEL1310110063#
product: MODEL1310110063#
reactant: MODEL1310110063#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: isomerization of (C18:4)m
type: Reaction

metaM hpdcacoa c
constant: false
initial concentration: 1.0
initial amount: NaN
type: Species
notes: FORMULA: C38H64N7O17P3S CHARGE: -4 INCHI: InChI=1/C38H68N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-29(47)66-22-21-40-28(46)19-20-41-36(50)33(49)38(2,3)24-59-65(56,57)62-64(54,55)58-23-27-32(61-63(51,52)53)31(48)37(60-27)45-26-44-30-34(39)42-25-43-35(30)45/h25-27,31-33,37,48-49H,4-24H2,1-3H3,(H,40,46)(H,41,50)(H,54,55)(H,56,57)(H2,39,42,43)(H2,51,52,53)/t27-,31-,32-,33+,37-/m1/s1
boundary condition: false
is: SBO:0000247
name: heptadecanoyl coa
is: HMDB06497
has only substance units: false

metaM idp n
initial amount: NaN
constant: false
is: HMDB03335
boundary condition: false
initial concentration: 1.0
is: CHEBI:58280
has only substance units: false
name: IDP(3-)
notes: FORMULA: C10H11N4O11P2 CHARGE: -3 INCHI: InChI=1S/C10H14N4O11P2/c15-6-4(1-23-27(21,22)25-26(18,19)20)24-10(7(6)16)14-3-13-5-8(14)11-2-12-9(5)17/h2-4,6-7,10,15-16H,1H2,(H,21,22)(H,11,12,17)(H2,18,19,20)/p-3/t4-,6-,7-,10-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00104 EHMN_ABBREVIATION: C00104
is: SBO:0000247
type: Species

metaR SIAASE3ly
fast: false
is version of: http://identifiers.org/ec-code/3.2.1.18
is version of: http://identifiers.org/ec-code/3.4.16.5
type: Reaction
kinetic law: MODEL1310110063#
is described by: ECO:0000000
is: SBO:0000176
product: MODEL1310110063#
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.18 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD
is version of: http://identifiers.org/ec-code/3.2.1.23
modifier: MODEL1310110063#
reversible: false
name: sialidase, lysosomal
is version of: http://identifiers.org/ec-code/3.1.6.4
reactant: MODEL1310110063#

metaR EX prostge1 LPAREN e RPAREN
kinetic law: MODEL1310110063#
reactant: MODEL1310110063#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Prostaglandin E1 exchange
type: Reaction

metaR r2324
is: SBO:0000185
kinetic law: MODEL1310110063#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
reversible: true
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
product: MODEL1310110063#
type: Reaction
reactant: MODEL1310110063#
fast: false

metaM 2decdicoa m
initial concentration: 1.0
type: Species
constant: false
name: 2,7-decadienoylcoa
boundary condition: false
is: SBO:0000247
notes: FORMULA: C31H46N7O17P3S CHARGE: -4
is: http://identifiers.org/pubchem.compound/16019966
initial amount: NaN
has only substance units: false

metaM q10 e
constant: false
initial amount: NaN
is: CHEBI:46245
name: ubiquinone-10
type: Species
has only substance units: false
boundary condition: false
notes: FORMULA: C59H90O4 CHARGE: 0 INCHI: InChI=1S/C59H90O4/c1-44(2)24-15-25-45(3)26-16-27-46(4)28-17-29-47(5)30-18-31-48(6)32-19-33-49(7)34-20-35-50(8)36-21-37-51(9)38-22-39-52(10)40-23-41-53(11)42-43-55-54(12)56(60)58(62-13)59(63-14)57(55)61/h24,26,28,30,32,34,36,38,40,42H,15-23,25,27,29,31,33,35,37,39,41,43H2,1-14H3/b45-26+,46-28+,47-30+,48-32+,49-34+,50-36+,51-38+,52-40+,53-42+
is: SBO:0000247
is: HMDB01072
initial concentration: 1.0

metaR RE1796M
modifier: MODEL1310110063#
reactant: MODEL1310110063#
is described by: ECO:0000000
product: MODEL1310110063#
type: Reaction
reversible: true
is version of: http://identifiers.org/ec-code/1.1.1.145
name: RE1796
fast: false
notes: GENE_ASSOCIATION: (3283.1) or (3284.1) SUBSYSTEM: Bile acid synthesis EC Number: 5.3.3.1 Confidence Level: 0 AUTHORS: PMID:10599696,PMID:11067870,PMID:11454857,PMID:1401999 NOTES:
kinetic law: MODEL1310110063#
is: SBO:0000176

metaR MAOX
fast: false
is version of: http://identifiers.org/ec-code/1.4.3.22
modifier: MODEL1310110063#
reactant: MODEL1310110063#
is version of: http://identifiers.org/ec-code/1.4.3.21
kinetic law: MODEL1310110063#
is described by: ECO:0000304
name: Methylamine oxidase
product: MODEL1310110063#
type: Reaction
is: SBO:0000176
notes: GENE_ASSOCIATION: (8639.1) or (26.1) or (314.2) or (314.1) SUBSYSTEM: Tyrosine metabolism EC Number: 1.4.3.6 Confidence Level: 2 AUTHORS: PMID:11136547,PMID:14715500,PMID:9131641 NOTES:SAB
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110063#_e88679b0_732d_4bde_b6e4_cdc37f7775a5
constant: false
initial amount: NaN
initial concentration: NaN
type: Species
is: P32189
has only substance units: false
is: SBO:0000252
name: GK
boundary condition: true
is encoded by: hsa:2710

metaR r2034
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
type: Reaction
reversible: false
is described by: ECO:0000000
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.15
product: MODEL1310110063#
fast: false
is: SBO:0000185
modifier: MODEL1310110063#
reactant: MODEL1310110063#
kinetic law: MODEL1310110063#

metaR FRDPtr
is described by: ECO:0000000
is: SBO:0000185
reactant: MODEL1310110063#
reversible: true
kinetic law: MODEL1310110063#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: PMID:12121718,PMID:12840657,PMID:14713247 NOTES:cholesterol precursor, transport by "diffusion" -> actually beleived to be flip-flop mechanism (PMID: 12840657). See also Krisans (PMID: 14713247, PMID: 12121718) for synthesis of cholesterol pathway (why FRDP needs to be transported between ER and peroxisome) NJ
product: MODEL1310110063#
type: Reaction
name: lipid, flip-flop intracellular transport

metaM m2gacpail hs r
constant: false
initial amount: NaN
has only substance units: false
is: SBO:0000247
name: dimannosyl-glucosaminyl-acylphosphatidylinositol (H3)
boundary condition: false
notes: FORMULA: C43H78NO24PFULLRCO2FULLR2CO2 CHARGE: 0
is: CHEBI:16038
initial concentration: 1.0
type: Species

metaM accoa c
constant: false
initial concentration: 1.0
boundary condition: false
is: SBO:0000247
name: Acetyl-CoA
has only substance units: false
initial amount: NaN
is: CHEBI:57288
type: Species
is: HMDB01206
notes: FORMULA: C23H34N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00033 EHMN_ABBREVIATION: C00024
is: C00024

metaM 3hbcoa m
boundary condition: false
initial concentration: 1.0
type: Species
name: (S)-3-hydroxybutanoyl-CoA(4-)
is: HMDB01166
is: CHEBI:57316
constant: false
notes: FORMULA: C25H38N7O18P3S CHARGE: -4 INCHI: InChI=1S/C25H42N7O18P3S/c1-13(33)8-16(35)54-7-6-27-15(34)4-5-28-23(38)20(37)25(2,3)10-47-53(44,45)50-52(42,43)46-9-14-19(49-51(39,40)41)18(36)24(48-14)32-12-31-17-21(26)29-11-30-22(17)32/h11-14,18-20,24,33,36-37H,4-10H2,1-3H3,(H,27,34)(H,28,38)(H,42,43)(H,44,45)(H2,26,29,30)(H2,39,40,41)/p-4/t13-,14+,18+,19+,20-,24+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00686 EHMN_ABBREVIATION: C01144
initial amount: NaN
is: SBO:0000247
has only substance units: false

metaR THRSERNaEx
kinetic law: MODEL1310110063#
reversible: false
modifier: MODEL1310110063#
reactant: MODEL1310110063#
is: SBO:0000185
type: Reaction
fast: false
name: L-serine/L-threonine Na-dependent exchange (Thr-L in)
product: MODEL1310110063#
notes: GENE_ASSOCIATION: (6509.1) or (6510.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14530974 NOTES:SAB see Kanai and Hediger 2004 (2003), PMID 14530974
is described by: ECO:0000269

metaR ALAt2r
name: L-alanine reversible transport via proton symport
kinetic law: MODEL1310110063#
is described by: ECO:0000304
modifier: MODEL1310110063#
notes: GENE_ASSOCIATION: (206358.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11390972,PMID:11959859 NOTES:NCD
reversible: true
product: MODEL1310110063#
fast: false
reactant: MODEL1310110063#
is: SBO:0000185
type: Reaction

metaM retinol cis 13 c
constant: false
name: 13-cis-retinol
is: HMDB06217
has only substance units: false
is: CHEBI:45479
boundary condition: false
initial concentration: 1.0
is: SBO:0000247
type: Species
initial amount: NaN
notes: FORMULA: C20H30O CHARGE: 0 INCHI: InChI=1S/C20H30O/c1-16(8-6-9-17(2)13-15-21)11-12-19-18(3)10-7-14-20(19,4)5/h6,8-9,11-13,21H,7,10,14-15H2,1-5H3/b9-6+,12-11+,16-8+,17-13-

metaR NACHEX13ly
notes: GENE_ASSOCIATION: (3074.1) or (3073.1) or (3073.1 and 3074.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.52 Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12706724,PMID:8993162 NOTES:NCD
is described by: ECO:0000000
fast: false
type: Reaction
reactant: MODEL1310110063#
name: beta-N-acetylhexosaminidase, lysosomal
is version of: http://identifiers.org/ec-code/3.2.1.52
reversible: false
modifier: MODEL1310110063#
kinetic law: MODEL1310110063#
product: MODEL1310110063#
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110063#_788f1ea7_7b55_423f_b6ea_3b1f2421e914
constant: false
type: Species
initial concentration: NaN
initial amount: NaN
name: AMPD2
is: SBO:0000252
has only substance units: false
is encoded by: hsa:271
is: B2RB47
boundary condition: true

metaM fe2 c
name: Fe2+
is: C00023
is: CHEBI:29033
constant: false
initial amount: NaN
notes: FORMULA: Fe CHARGE: 2 HEPATONET_1.0_ABBREVIATION: HC01846 EHMN_ABBREVIATION: C00023
has only substance units: false
boundary condition: false
initial concentration: 1.0
is: HMDB00692
is: SBO:0000247
type: Species

metaR RE3627M
type: Reaction
fast: false
is: SBO:0000176
kinetic law: MODEL1310110063#
product: MODEL1310110063#
notes: GENE_ASSOCIATION: (3295.1) or (1962.1) or (3033.1) or (3028.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.1.1.35 Confidence Level: 0 AUTHORS: PMID:11356164,PMID:7775433 NOTES:
modifier: MODEL1310110063#
name: RE3627
is version of: http://identifiers.org/ec-code/1.1.1.35
reversible: true
is described by: ECO:0000000
reactant: MODEL1310110063#
is version of: http://identifiers.org/ec-code/4.2.1.107

metaR r2325
kinetic law: MODEL1310110063#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
product: MODEL1310110063#
is described by: ECO:0000000
reversible: true
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
reactant: MODEL1310110063#
is: SBO:0000185
type: Reaction
fast: false

metaM sphs1p c
name: sphingosine 1-phosphate(1-)
type: Species
initial amount: NaN
notes: FORMULA: C18H37NO5P CHARGE: -1 INCHI: InChI=1S/C18H38NO5P/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-18(20)17(19)16-24-25(21,22)23/h14-15,17-18,20H,2-13,16,19H2,1H3,(H2,21,22,23)/p-1/b15-14+/t17-,18+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01702 EHMN_ABBREVIATION: C06124
is: HMDB00277
is: SBO:0000247
is: CHEBI:60119
constant: false
has only substance units: false
initial concentration: 1.0
boundary condition: false

metaM acnacngalgbside hs e
notes: FORMULA: C72H121N4O43FULLRCO CHARGE: -2
boundary condition: false
name: disialyl galactosylgloboside
is: SBO:0000247
is: CHEBI:3338
type: Species
has only substance units: false
initial amount: NaN
is: HMDB00223
is: C00036
initial concentration: 1.0
constant: false

http://identifiers.org/biomodels.db/MODEL1310110063#_3fc7f19f_405c_4766_811c_bd0db461d921
is encoded by: hsa:7357
initial amount: NaN
is: SBO:0000252
constant: false
has only substance units: false
is: Q16739
initial concentration: NaN
type: Species
name: UGCG
boundary condition: true

metaR FAOXC141C121x
kinetic law: MODEL1310110063#
product: MODEL1310110063#
reactant: MODEL1310110063#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta xoidation(C14:1-->C12:1)x
type: Reaction

metaR RE0689E
fast: false
name: RE0689
modifier: MODEL1310110063#
reversible: false
is version of: http://identifiers.org/ec-code/1.4.3.22
notes: GENE_ASSOCIATION: (26.1) SUBSYSTEM: Urea cycle EC Number: 1.4.3.6 Confidence Level: 0 AUTHORS: PMID:10047787,PMID:7040832 NOTES:
product: MODEL1310110063#
kinetic law: MODEL1310110063#
is: SBO:0000176
type: Reaction
is described by: ECO:0000000
reactant: MODEL1310110063#

http://identifiers.org/biomodels.db/MODEL1310110063#_7e7bbdff_87fe_4a25_9c03_39ac337481b8
type: Species
is encoded by: hsa:5293
initial amount: NaN
has only substance units: false
name: PIK3CD
is: A7E2E0
initial concentration: NaN
constant: false
boundary condition: true
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110063#_c79ddac1_af72_40fb_b9dc_ed75d9d821c2
type: Species
constant: false
is encoded by: hsa:80271
boundary condition: true
initial amount: NaN
is: SBO:0000252
is: Q96DU7
name: ITPKC
initial concentration: NaN
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110063#_0a9446e2_ad0a_405e_9cdd_f5f985dd197f
initial amount: NaN
has only substance units: false
name: _AW299740_1_m
constant: false
is: SBO:0000252
type: Species
is encoded by: hsa:AW299740
boundary condition: true
initial concentration: NaN

metaR GALASE13ly
is described by: ECO:0000000
is: SBO:0000176
reactant: MODEL1310110063#
product: MODEL1310110063#
fast: false
is version of: http://identifiers.org/ec-code/3.2.1.23
name: beta-galactosidase, lysosomal
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) or (5476.1) and (2720.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.23 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD
reversible: false
modifier: MODEL1310110063#
is version of: http://identifiers.org/ec-code/3.4.16.5
kinetic law: MODEL1310110063#
type: Reaction
is version of: http://identifiers.org/ec-code/3.1.6.4
is version of: http://identifiers.org/ec-code/3.2.1.18

metaM his L m
name: L-histidine
notes: FORMULA: C6H9N3O2 CHARGE: 0 INCHI: InChI=1S/C6H9N3O2/c7-5(6(10)11)1-4-2-8-3-9-4/h2-3,5H,1,7H2,(H,8,9)(H,10,11)/t5-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00133
has only substance units: false
initial concentration: 1.0
type: Species
boundary condition: false
is: CHEBI:15971
is: HMDB00177
initial amount: NaN
is: SBO:0000247
constant: false

metaM hx2coa x
constant: false
is: http://identifiers.org/pubchem.compound/11966188
notes: FORMULA: C27H40N7O17P3S CHARGE: -4
boundary condition: false
has only substance units: false
name: trans-Hex-2-enoyl-CoA
is: SBO:0000247
initial concentration: 1.0
is: HMDB06870
initial amount: NaN
is: C05998
type: Species

http://identifiers.org/biomodels.db/MODEL1310110063#_bb48b411_c586_45c3_b373_ab70afc8f71a
name: TXNRD1
initial concentration: NaN
is encoded by: hsa:7296
has only substance units: false
constant: false
is: SBO:0000252
initial amount: NaN
type: Species
boundary condition: true

metaR r2322
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
is: SBO:0000185
is described by: ECO:0000000
reversible: true
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
product: MODEL1310110063#
type: Reaction
fast: false
kinetic law: MODEL1310110063#
reactant: MODEL1310110063#

metaR CYTK4n
fast: false
modifier: MODEL1310110063#
reversible: true
name: cytidylate kinase (dCMP,GTP),nuclear
is described by: ECO:0000269
product: MODEL1310110063#
reactant: MODEL1310110063#
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
is version of: http://identifiers.org/ec-code/2.7.4.14
is: SBO:0000176
kinetic law: MODEL1310110063#
type: Reaction

metaR ORNt4m
reversible: true
product: MODEL1310110063#
is described by: ECO:0000269
kinetic law: MODEL1310110063#
type: Reaction
reactant: MODEL1310110063#
modifier: MODEL1310110063#
is: SBO:0000185
notes: GENE_ASSOCIATION: (10166.1) or (83884.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172 NOTES:TDV (ornithine carrier)
fast: false
name: ornithine mitochondrial transport exchange with citruline

http://identifiers.org/biomodels.db/MODEL1310110063#_c37d0d40_8d57_41d6_ba70_475d1ba2a5c8
initial concentration: NaN
constant: false
is encoded by: hsa:4709
initial amount: NaN
boundary condition: true
is: Q6IB80
is: SBO:0000252
name: NDUFB3
type: Species
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110063#_7ccbd5ac_db3e_4810_ba96_8ee2f0b10684
is: SBO:0000252
is: F5GWS5
boundary condition: true
has only substance units: false
initial amount: NaN
constant: false
type: Species
name: ADCY10
is encoded by: hsa:55811
initial concentration: NaN

metaM hs deg15 l
boundary condition: false
notes: FORMULA: C49H71N2O57S5 CHARGE: -7
type: Species
name: heparan sulfate, degradation product 15
initial amount: NaN
is: CHEBI:16126
constant: false
has only substance units: false
initial concentration: 1.0
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110063#_309c8717_61d8_4c88_b52c_359bb2bb5f8d
constant: false
boundary condition: true
initial amount: NaN
is: SBO:0000252
is: P07451
name: CA3
is encoded by: hsa:761
has only substance units: false
initial concentration: NaN
type: Species

metaR PI5P3K
is described by: ECO:0000000
fast: false
is version of: http://identifiers.org/ec-code/2.7.1.153
is version of: http://identifiers.org/ec-code/2.7.1.137
modifier: MODEL1310110063#
type: Reaction
product: MODEL1310110063#
is version of: http://identifiers.org/ec-code/2.7.11.1
kinetic law: MODEL1310110063#
reversible: false
is version of: http://identifiers.org/ec-code/2.7.1.154
reactant: MODEL1310110063#
is: SBO:0000176
name: phosphatidylinositol-5-phosphate 3-kinase
notes: GENE_ASSOCIATION: (5295.2 and 5291.1) or (23533.1 and 5294.1) or (5295.2 and 5290.1) or (5293.1 and 5295.3) or (5287.1) or (5286.1) or (5293.1 and 5296.1) or (5295.2 and 5293.1) or (5296.1 and 5291.1) or (5290.1 and 5295.1) or (5288.1) or (5290.1 and 8503.1) or (5291.1 and 5295.3) or (10870.1 and 5294.1) or (5291.1 and 8503.1) or (5293.1 and 5295.1) or (5296.1 and 5290.1) or (5289.1) or (5293.1 and 8503.1) or (5291.1 and 5295.1) or (5290.1 and 5295.3) SUBSYSTEM: Inositol phosphate metabolism EC Number: Confidence Level: 1 AUTHORS: PMID:10358929 NOTES:NCD

metaR FAOXC225C204x
kinetic law: MODEL1310110063#
product: MODEL1310110063#
reactant: MODEL1310110063#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C22:5-->C20:4)x
type: Reaction

metaM T antigen g
is: SBO:0000247
is: CHEBI:22783
notes: FORMULA: C14H24NO10X CHARGE: 0
initial amount: NaN
name: T antigen (core 1)
has only substance units: false
constant: false
initial concentration: 1.0
boundary condition: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110063#_e94629bb_bc57_4b4a_a578_92ddea31b9b2
type: Species
is encoded by: hsa:6390
is: SBO:0000252
has only substance units: false
is: P21912
initial amount: NaN
name: SDHB
boundary condition: true
initial concentration: NaN
constant: false

http://identifiers.org/biomodels.db/MODEL1310110063#_773a994c_c407_48f2_b9f4_cdad886105ab
has only substance units: false
is: O75874
initial amount: NaN
name: IDH1
constant: false
boundary condition: true
is: SBO:0000252
is encoded by: hsa:3417
type: Species
initial concentration: NaN

metaM 2hexdtetcoa m
is: SBO:0000247
notes: FORMULA: C37H54N7O17P3S CHARGE: -4
has only substance units: false
constant: false
initial amount: NaN
name: 2,7,10,13-hexadecatetraenoylcoa
type: Species
is: HMDB02288
initial concentration: 1.0
boundary condition: false

metaR r2323
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
is described by: ECO:0000000
product: MODEL1310110063#
fast: false
reversible: true
reactant: MODEL1310110063#
is: SBO:0000185
kinetic law: MODEL1310110063#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
type: Reaction

metaR r0661
is: SBO:0000176
name: (S)-3-Hydroxydodecanoyl-CoA hydro-lyase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:4.2.1.17
fast: false
type: Reaction
kinetic law: MODEL1310110063#
reversible: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.17 Confidence Level: 0 AUTHORS: PMID:8012501,PMID:8188243 NOTES:
is described by: ECO:0000000
reactant: MODEL1310110063#
product: MODEL1310110063#

metaR FACOAL160i
reactant: MODEL1310110063#
product: MODEL1310110063#
fast: false
is: SBO:0000176
reversible: false
type: Reaction
modifier: MODEL1310110063#
is version of: http://identifiers.org/ec-code/6.2.1.3
name: C160 fatty acid activation
is described by: ECO:0000269
kinetic law: MODEL1310110063#
notes: GENE_ASSOCIATION: (2181.2) or (22305.2) or (51703.1) or (22305.1) or (2180.1) or (2181.1) SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 4 AUTHORS: PMID:1531127 NOTES:TV catalyzed by acyl-CoA synthetases

metaM acnacngalgbside hs g
is: CHEBI:3338
notes: FORMULA: C72H121N4O43FULLRCO CHARGE: -2
boundary condition: false
type: Species
initial amount: NaN
name: disialyl galactosylgloboside
is: HMDB00223
is: C00036
constant: false
has only substance units: false
initial concentration: 1.0
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110063#_74a1e57d_d8fd_41ec_83fc_de3d63b158c2
is: SBO:0000252
is encoded by: hsa:54677
name: CROT
is: E7EQF2
initial amount: NaN
boundary condition: true
has only substance units: false
initial concentration: NaN
constant: false
type: Species

metaR r1618
kinetic law: MODEL1310110063#
is described by: ECO:0000000
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is: SBO:0000185
product: MODEL1310110063#
modifier: MODEL1310110063#
reactant: MODEL1310110063#
notes: GENE_ASSOCIATION: (19.1) or (AL038231.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reversible: true
fast: false
type: Reaction

metaM ksi pre28 g
notes: FORMULA: C213H341N15O176S8X CHARGE: -9
is: SBO:0000247
type: Species
constant: false
is: CHEBI:58053
is: C00130
name: keratan sulfate I biosynthesis, precursor 28
boundary condition: false
is: HMDB00175
initial concentration: 1.0
has only substance units: false
initial amount: NaN

metaR GCALDD
name: Glycolaldehyde dehydrogenase
is version of: http://identifiers.org/ec-code/1.2.1.3
fast: false
reactant: MODEL1310110063#
is described by: ECO:0000304
notes: GENE_ASSOCIATION: (218.1) or (223.1) or (8854.2) or (224.1) or (222.1) or (8854.1) or (221.1) or (216.1) or (8854.3) or (501.1) or (220.1) SUBSYSTEM: Glyoxylate and dicarboxylate metabolism EC Number: 1.2.1.21 Confidence Level: 2 AUTHORS: PMID:11434452 NOTES:JLR
product: MODEL1310110063#
is version of: http://identifiers.org/ec-code/1.2.1.5
is: SBO:0000176
kinetic law: MODEL1310110063#
modifier: MODEL1310110063#
is version of: http://identifiers.org/ec-code/1.2.1.36
type: Reaction
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110063#_67d30e04_2ada_4e5a_91f8_0ddc28ed1ac4
initial amount: NaN
type: Species
has only substance units: false
is encoded by: hsa:728226
is: SBO:0000252
initial concentration: NaN
constant: false
boundary condition: true
name: _728226_1_e

metaR MACACI
kinetic law: MODEL1310110063#
type: Reaction
product: MODEL1310110063#
notes: GENE_ASSOCIATION: (2954.1) or (2954.3) or (2954.2) SUBSYSTEM: Tyrosine metabolism EC Number: 5.2.1.2 Confidence Level: 4 AUTHORS: PMID:10373324 NOTES:NCD
is: SBO:0000176
fast: false
modifier: MODEL1310110063#
name: maleylacetoacetate isomerase
is described by: ECO:0000269
reactant: MODEL1310110063#
reversible: false
is version of: http://identifiers.org/ec-code/2.5.1.18

http://identifiers.org/biomodels.db/MODEL1310110063#_642b1f8a_3248_48cb_8615_28fe8112ae75
name: UPP1
constant: false
is: SBO:0000252
initial concentration: NaN
is encoded by: hsa:7378
type: Species
has only substance units: false
initial amount: NaN
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110063#_993c7113_6362_40d9_8e44_5482c2fd4016
boundary condition: true
is: SBO:0000252
initial amount: NaN
initial concentration: NaN
name: _HG2846_HT2983_1_c
type: Species
has only substance units: false
constant: false
is encoded by: hsa:HG2846-HT2983

metaM his L c
boundary condition: false
is: SBO:0000247
type: Species
initial concentration: 1.0
is: HMDB00177
has only substance units: false
is: CHEBI:15971
notes: FORMULA: C6H9N3O2 CHARGE: 0 INCHI: InChI=1S/C6H9N3O2/c7-5(6(10)11)1-4-2-8-3-9-4/h2-3,5H,1,7H2,(H,8,9)(H,10,11)/t5-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00133
name: L-histidine
initial amount: NaN
constant: false

http://identifiers.org/biomodels.db/MODEL1310110063#_373226d1_92d3_44b2_b8bb_7ca7193a65d4
initial amount: NaN
boundary condition: true
constant: false
is: SBO:0000252
type: Species
name: SLC22A3
is encoded by: hsa:6581
initial concentration: NaN
is: Q5SYN6
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110063#_6e06ef82_1f1a_4d2a_b832_1852c73a2c8d
is: Q9NPB1
constant: false
is: SBO:0000252
has only substance units: false
boundary condition: true
type: Species
initial concentration: NaN
name: NT5M
initial amount: NaN
is encoded by: hsa:56953

metaR FACOAL1831
reactant: MODEL1310110063#
is described by: ECO:0000269
fast: false
notes: GENE_ASSOCIATION: (2180.1) SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 4 AUTHORS: PMID:15292367 NOTES:NJ
kinetic law: MODEL1310110063#
modifier: MODEL1310110063#
product: MODEL1310110063#
is: SBO:0000176
reversible: true
type: Reaction
is version of: http://identifiers.org/ec-code/6.2.1.3
name: fatty-acid--CoA ligase

http://identifiers.org/biomodels.db/MODEL1310110063#_c67f7d7d_53ef_4c4a_b9d1_8a26a6ea4f14
boundary condition: true
is: SBO:0000252
has only substance units: false
name: ACAT2
type: Species
initial concentration: NaN
initial amount: NaN
is: Q9BWD1
constant: false
is encoded by: hsa:39

metaR FAOXC225C226x
kinetic law: MODEL1310110063#
product: MODEL1310110063#
reactant: MODEL1310110063#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C22:5-->C22:6)x
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110063#_b99f7f56_a51e_45fa_93f7_b63ea8a4a6f1
has only substance units: false
boundary condition: true
is: SBO:0000252
constant: false
is: P14618
type: Species
is encoded by: hsa:5315
initial concentration: NaN
initial amount: NaN
name: PKM2

http://identifiers.org/biomodels.db/MODEL1310110063#_a7d353da_8cde_402d_8d90_7c364d4ae746
has only substance units: false
is: SBO:0000252
initial amount: NaN
is: Q5JT09
constant: false
is encoded by: hsa:83549
boundary condition: true
type: Species
name: UCK1
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110063#_81f0f954_a74e_4771_bb01_8433c7b38121
is: Q96CA6
initial concentration: NaN
is: SBO:0000252
initial amount: NaN
boundary condition: true
name: ACAA1
is encoded by: hsa:30
has only substance units: false
constant: false
type: Species

metaR NADS2
is version of: http://identifiers.org/ec-code/6.3.5.1
reactant: MODEL1310110063#
type: Reaction
product: MODEL1310110063#
is: SBO:0000176
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (55191.1) SUBSYSTEM: NAD metabolism EC Number: Confidence Level: 4 AUTHORS: NOTES:
reversible: false
name: NAD synthase (glutamine-hydrolysing)
kinetic law: MODEL1310110063#
fast: false
modifier: MODEL1310110063#

metaR FACOAL1832
notes: GENE_ASSOCIATION: (2180.1) SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 4 AUTHORS: PMID:15292367 NOTES:NJ, RE3114C
name: fatty-acid--CoA ligase
kinetic law: MODEL1310110063#
modifier: MODEL1310110063#
is described by: ECO:0000269
fast: false
reversible: true
is version of: http://identifiers.org/ec-code/6.2.1.3
product: MODEL1310110063#
type: Reaction
reactant: MODEL1310110063#
is: SBO:0000176

metaR EX dttp LPAREN e RPAREN
kinetic law: MODEL1310110063#
reactant: MODEL1310110063#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of dTTP(4-)
type: Reaction

metaM dsmsterol r
is: CHEBI:17737
initial concentration: 1.0
name: desmosterol
boundary condition: false
is: SBO:0000247
initial amount: NaN
notes: FORMULA: C27H44O CHARGE: 0 INCHI: InChI=1S/C27H44O/c1-18(2)7-6-8-19(3)23-11-12-24-22-10-9-20-17-21(28)13-15-26(20,4)25(22)14-16-27(23,24)5/h7,9,19,21-25,28H,6,8,10-17H2,1-5H3/t19-,21+,22+,23-,24+,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00847 EHMN_ABBREVIATION: C01802
constant: false
has only substance units: false
type: Species
is: HMDB02719

metaR r1617
is described by: ECO:0000000
kinetic law: MODEL1310110063#
modifier: MODEL1310110063#
is: SBO:0000185
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
notes: GENE_ASSOCIATION: (19.1) or (AL038231.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
fast: false
reversible: true
type: Reaction
reactant: MODEL1310110063#
product: MODEL1310110063#

metaM CE5132 n
is: CHEBI:57923
initial amount: NaN
type: Species
boundary condition: false
initial concentration: 1.0
notes: FORMULA: C11H14O19P3R2 CHARGE: -5 EHMN_ABBREVIATION: CE5132
is: SBO:0000247
has only substance units: false
name: 1-phosphatidyl-1D-myo-inositol 3,5-bisphosphate(5-)
constant: false

metaR r0668
is version of: http://identifiers.org/ec-code/2.4.2.19
kinetic law: MODEL1310110063#
notes: GENE_ASSOCIATION: (AI539321.1) or (23475.1) SUBSYSTEM: Unassigned EC Number: 2.7.7.43 Confidence Level: 0 AUTHORS: PMID:1577759,PMID:422125,PMID:4288894,PMID:4803836,PMID:9689047 NOTES:
reactant: MODEL1310110063#
type: Reaction
name: CTP:N-acylneuraminate cytidylyltransferase Aminosugars metabolism EC:2.7.7.43
modifier: MODEL1310110063#
is described by: ECO:0000000
fast: false
reversible: true
product: MODEL1310110063#
is: SBO:0000176

metaM prgstrn c
initial amount: NaN
is: CHEBI:17026
initial concentration: 1.0
is: HMDB01830
has only substance units: false
boundary condition: false
notes: FORMULA: C21H30O2 CHARGE: 0 INCHI: InChI=1S/C21H30O2/c1-13(22)17-6-7-18-16-5-4-14-12-15(23)8-10-20(14,2)19(16)9-11-21(17,18)3/h12,16-19H,4-11H2,1-3H3/t16-,17+,18-,19-,20-,21+/m0/s1 EHMN_ABBREVIATION: C00410
is: SBO:0000247
constant: false
type: Species
name: progesterone

metaM pi n
has only substance units: false
type: Species
boundary condition: false
constant: false
name: hydrogenphosphate
is: HMDB00973
is: SBO:0000247
notes: FORMULA: HO4P CHARGE: -2 INCHI: InChI=1S/H3O4P/c1-5(2,3)4/h(H3,1,2,3,4)/p-2 HEPATONET_1.0_ABBREVIATION: HC00019 EHMN_ABBREVIATION: C00009
initial amount: NaN
is: CHEBI:43474
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110063#_a5909f7c_9e1e_46bc_a41d_0ae54ec739b2
type: Species
is: P06865
initial amount: NaN
initial concentration: NaN
has only substance units: false
constant: false
is: SBO:0000252
boundary condition: true
name: HEXA
is encoded by: hsa:3073

http://identifiers.org/biomodels.db/MODEL1310110063#_ea9b6d8e_9d25_48a9_a3c1_e17d0cdceca9
boundary condition: true
name: _R14373_1_x
initial concentration: NaN
is encoded by: hsa:R14373
constant: false
type: Species
is: SBO:0000252
has only substance units: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110063#_bee3ca59_c0ab_4d09_9d2c_788a7137e820
initial concentration: NaN
constant: false
initial amount: NaN
is: SBO:0000252
is encoded by: hsa:51
type: Species
name: ACOX1
is: Q15067
has only substance units: false
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110063#_4142a93a_e098_45ca_aa9f_6d9afe7b96be
is: P11498
boundary condition: true
has only substance units: false
is encoded by: hsa:5091
initial concentration: NaN
type: Species
initial amount: NaN
name: PC
is: SBO:0000252
constant: false

http://identifiers.org/biomodels.db/MODEL1310110063#_74854836_160d_4f1a_9cad_beffb9e6039e
name: RDH14
is: Q9HBH5
initial concentration: NaN
initial amount: NaN
type: Species
boundary condition: true
has only substance units: false
constant: false
is: SBO:0000252
is encoded by: hsa:57665

metaR MMMm
type: Reaction
is version of: http://identifiers.org/ec-code/5.4.99.2
reversible: true
reactant: MODEL1310110063#
is described by: ECO:0000269
name: methylmalonyl-CoA mutase
notes: GENE_ASSOCIATION: (4594.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 5.4.99.2 Confidence Level: 4 AUTHORS: PMID:8990001 NOTES:TDV
fast: false
is: SBO:0000176
kinetic law: MODEL1310110063#
modifier: MODEL1310110063#
product: MODEL1310110063#

http://identifiers.org/biomodels.db/MODEL1310110063#_16f3400f_7ee6_4987_a39e_7bf7d4fa7aae
type: Species
is: SBO:0000252
constant: false
has only substance units: false
is encoded by: hsa:J03866
name: _J03866_1_m
initial amount: NaN
initial concentration: NaN
boundary condition: true

metaM udp l
is: HMDB00295
is: SBO:0000247
is: CHEBI:58223
type: Species
name: UDP(3-)
constant: false
notes: FORMULA: C9H11N2O12P2 CHARGE: -3 INCHI: InChI=1S/C9H14N2O12P2/c12-5-1-2-11(9(15)10-5)8-7(14)6(13)4(22-8)3-21-25(19,20)23-24(16,17)18/h1-2,4,6-8,13-14H,3H2,(H,19,20)(H,10,12,15)(H2,16,17,18)/p-3/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00025 EHMN_ABBREVIATION: C00015
boundary condition: false
has only substance units: false
initial amount: NaN
initial concentration: 1.0

metaR CSNAT2m
is: SBO:0000176
reversible: true
is version of: http://identifiers.org/ec-code/2.3.1.7
fast: false
notes: GENE_ASSOCIATION: (1384.1) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.7 Confidence Level: 4 AUTHORS: PMID:11257506,PMID:3759988 NOTES:TDV
reactant: MODEL1310110063#
is described by: ECO:0000000
name: carnitine O-aceyltransferase, mitochondrial
kinetic law: MODEL1310110063#
type: Reaction
modifier: MODEL1310110063#
product: MODEL1310110063#

metaM fe2 e
boundary condition: false
is: C00023
notes: FORMULA: Fe CHARGE: 2 HEPATONET_1.0_ABBREVIATION: HC01846 EHMN_ABBREVIATION: C00023
is: SBO:0000247
type: Species
has only substance units: false
constant: false
initial amount: NaN
initial concentration: 1.0
is: HMDB00692
is: CHEBI:29033
name: Fe2+

metaR EX dopasf LPAREN e RPAREN
kinetic law: MODEL1310110063#
reactant: MODEL1310110063#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Dopamine 3-O-sulfate exchange
type: Reaction

metaR NOt
fast: false
reversible: true
kinetic law: MODEL1310110063#
reactant: MODEL1310110063#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 1 AUTHORS: NOTES:IT (06-16-04)
name: NO transport (diffusion)
is described by: ECO:0000000
product: MODEL1310110063#
type: Reaction
is: SBO:0000185

metaM arachcoa c
boundary condition: false
is: HMDB04258
is: CHEBI:15527
name: arachidyl coenzyme A
initial amount: NaN
has only substance units: false
is: SBO:0000247
constant: false
type: Species
notes: FORMULA: C41H70N7O17P3S CHARGE: -4 INCHI: InChI=1S/C41H74N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-32(50)69-25-24-43-31(49)22-23-44-39(53)36(52)41(2,3)27-62-68(59,60)65-67(57,58)61-26-30-35(64-66(54,55)56)34(51)40(63-30)48-29-47-33-37(42)45-28-46-38(33)48/h28-30,34-36,40,51-52H,4-27H2,1-3H3,(H,43,49)(H,44,53)(H,57,58)(H,59,60)(H2,42,45,46)(H2,54,55,56)/t30-,34-,35-,36+,40-/m1/s1 EHMN_ABBREVIATION: C02041
initial concentration: 1.0

metaR RE0453C
is described by: ECO:0000000
reactant: MODEL1310110063#
fast: false
is: SBO:0000176
product: MODEL1310110063#
name: RE0453
kinetic law: MODEL1310110063#
type: Reaction
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Pyrimidine synthesis EC Number: 2.7.4.6 Confidence Level: 0 AUTHORS: PMID:3026468 NOTES:

metaM 3hodcoa m
has only substance units: false
initial amount: NaN
initial concentration: 1.0
boundary condition: false
is: SBO:0000247
name: (S)-3-Hydroxyoctadecanoyl-CoA
notes: FORMULA: C39H66N7O18P3S CHARGE: -4
constant: false
is: http://identifiers.org/pubchem.compound/5280355
type: Species

metaR r0666
is version of: http://identifiers.org/ec-code/1.2.4.2
name: 2-(Formamido)-N1-(5-phosphoribosyl)acetamidine cyclo-ligase (ADP-forming) Purine metabolism EC:6.3.3.1
is: SBO:0000176
reversible: true
product: MODEL1310110063#
fast: false
reactant: MODEL1310110063#
type: Reaction
is described by: ECO:0000000
modifier: MODEL1310110063#
notes: GENE_ASSOCIATION: (4967.1) or (55753.1) SUBSYSTEM: Purine synthesis EC Number: 6.3.3.1 Confidence Level: 0 AUTHORS: PMID:4084560 NOTES:
kinetic law: MODEL1310110063#

metaM ksii core2 pre4 g
notes: FORMULA: C53H86N4O38X CHARGE: -1
is: C00130
initial concentration: 1.0
is: CHEBI:58053
type: Species
is: HMDB00175
initial amount: NaN
is: SBO:0000247
name: keratan sulfate II biosynthesis, precursor 4
boundary condition: false
has only substance units: false
constant: false

metaR r0129
name: gamma-glutamyltranspeptidase Glutathione metabolism EC:3.4.11.4
modifier: MODEL1310110063#
is: SBO:0000176
fast: false
type: Reaction
is version of: http://identifiers.org/ec-code/2.7.1.40
product: MODEL1310110063#
kinetic law: MODEL1310110063#
reversible: true
reactant: MODEL1310110063#
notes: GENE_ASSOCIATION: (H77542.1) or (5313.1) or (5315.1) SUBSYSTEM: Glutathione metabolism EC Number: 3.4.11.4 Confidence Level: 0 AUTHORS: PMID:1968061,PMID:3511062 NOTES:
is described by: ECO:0000000

metaR r1619
fast: false
kinetic law: MODEL1310110063#
modifier: MODEL1310110063#
is: SBO:0000185
reversible: true
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
product: MODEL1310110063#
type: Reaction
reactant: MODEL1310110063#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (19.1) or (AL038231.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:

metaR TREHe
fast: false
reversible: false
is described by: ECO:0000269
product: MODEL1310110063#
is version of: http://identifiers.org/ec-code/3.2.1.28
reactant: MODEL1310110063#
notes: GENE_ASSOCIATION: (11181.1) SUBSYSTEM: Starch and sucrose metabolism EC Number: 3.2.1.28 Confidence Level: 4 AUTHORS: PMID:12065209,PMID:9427547 NOTES:JLR
modifier: MODEL1310110063#
type: Reaction
is: SBO:0000176
name: alpha,alpha-trehalase
kinetic law: MODEL1310110063#

metaM q10 c
is: HMDB01072
is: SBO:0000247
type: Species
has only substance units: false
name: ubiquinone-10
notes: FORMULA: C59H90O4 CHARGE: 0 INCHI: InChI=1S/C59H90O4/c1-44(2)24-15-25-45(3)26-16-27-46(4)28-17-29-47(5)30-18-31-48(6)32-19-33-49(7)34-20-35-50(8)36-21-37-51(9)38-22-39-52(10)40-23-41-53(11)42-43-55-54(12)56(60)58(62-13)59(63-14)57(55)61/h24,26,28,30,32,34,36,38,40,42H,15-23,25,27,29,31,33,35,37,39,41,43H2,1-14H3/b45-26+,46-28+,47-30+,48-32+,49-34+,50-36+,51-38+,52-40+,53-42+ HEPATONET_1.0_ABBREVIATION: HC00329 EHMN_ABBREVIATION: C11378
initial concentration: 1.0
constant: false
initial amount: NaN
boundary condition: false
is: CHEBI:46245

metaR G14T16g
is version of: http://identifiers.org/ec-code/2.4.1.90
is: SBO:0000176
product: MODEL1310110063#
name: beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase, Golgi
fast: false
is described by: ECO:0000000
modifier: MODEL1310110063#
notes: GENE_ASSOCIATION: (8703.1) or (2683.1) or (8704.2) or (8704.1) or (9334.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.38 Confidence Level: 4 AUTHORS: PMID:12512857,PMID:1903938,PMID:3094506,PMID:3144273,PMID:9405390,PMID:9435216 NOTES:Keratan sulfate I biosynthesis NCD
is version of: http://identifiers.org/ec-code/2.4.1.22
type: Reaction
reversible: false
kinetic law: MODEL1310110063#
reactant: MODEL1310110063#
is version of: http://identifiers.org/ec-code/2.4.1.38

metaM CE5119 m
is: CHEBI:57923
is: SBO:0000247
initial amount: NaN
name: trans-3-cis-8-tetradecadienoyl-CoA
initial concentration: 1.0
constant: false
type: Species
notes: FORMULA: C35H54N7O17P3S CHARGE: -4 INCHI: InChI=1/C35H58N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-26(44)63-19-18-37-25(43)16-17-38-33(47)30(46)35(2,3)21-56-62(53,54)59-61(51,52)55-20-24-29(58-60(48,49)50)28(45)34(57-24)42-23-41-27-31(36)39-22-40-32(27)42/h8-9,13-14,22-24,28-30,34,45-46H,4-7,10-12,15-21H2,1-3H3,(H,37,43)(H,38,47)(H,51,52)(H,53,54)(H2,36,39,40)(H2,48,49,50)/p-4/b9-8-,14-13+/t24-,28+,29+,30u,34-/m0/s1 EHMN_ABBREVIATION: CE5119
boundary condition: false
has only substance units: false

metaM co c
is: SBO:0000247
notes: FORMULA: CO CHARGE: 0 INCHI: InChI=1S/CO/c1-2 EHMN_ABBREVIATION: C00237
boundary condition: false
name: carbon monoxide
initial amount: NaN
constant: false
is: CHEBI:17245
is: HMDB01361
has only substance units: false
type: Species
initial concentration: 1.0

metaM arg L m
type: Species
is: CHEBI:32682
has only substance units: false
name: L-argininium(1+)
constant: false
is: SBO:0000247
initial amount: NaN
is: HMDB00517
boundary condition: false
notes: FORMULA: C6H15N4O2 CHARGE: 1 INCHI: InChI=1S/C6H14N4O2/c7-4(5(11)12)2-1-3-10-6(8)9/h4H,1-3,7H2,(H,11,12)(H4,8,9,10)/p+1/t4-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00065
initial concentration: 1.0

metaR KYNAKGAT
modifier: MODEL1310110063#
name: L-Kynurenine:2-oxoglutarate aminotransferase
fast: false
is described by: ECO:0000269
reactant: MODEL1310110063#
is version of: http://identifiers.org/ec-code/2.6.1.7
kinetic law: MODEL1310110063#
product: MODEL1310110063#
notes: GENE_ASSOCIATION: (51166.1) or (883.1) or (51166.2) SUBSYSTEM: Tryptophan metabolism EC Number: 2.6.1.7 Confidence Level: 4 AUTHORS: PMID:15016471 NOTES:SAB
is: SBO:0000176
type: Reaction
reversible: false
is version of: http://identifiers.org/ec-code/2.6.1.64

metaM urcan c
is: CHEBI:17771
is: HMDB00301
initial concentration: 1.0
is: SBO:0000247
has only substance units: false
constant: false
notes: FORMULA: C6H5N2O2 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00534 EHMN_ABBREVIATION: C00785
initial amount: NaN
is: C00785
boundary condition: false
name: Urocanate
type: Species

metaR TRPHYDRO2
reactant: MODEL1310110063#
is version of: http://identifiers.org/ec-code/1.14.16.4
fast: false
kinetic law: MODEL1310110063#
product: MODEL1310110063#
name: L-Tryptophan,tetrahydrobiopterin:oxygen oxidoreductase (5-hydroxylating)
notes: GENE_ASSOCIATION: (7166.1) or (121278.1) SUBSYSTEM: Tryptophan metabolism EC Number: 1.14.16.4 Confidence Level: 4 AUTHORS: PMID:10727395,PMID:12379098 NOTES:SAB unlumped version of TRPHYDRO1
type: Reaction
reversible: false
modifier: MODEL1310110063#
is: SBO:0000176
is described by: ECO:0000269

http://identifiers.org/biomodels.db/MODEL1310110063#_6ab1d8d6_7715_488b_9eb2_cfd1b791cabd
has only substance units: false
boundary condition: true
initial concentration: NaN
name: PDE9A
initial amount: NaN
type: Species
is: SBO:0000252
is encoded by: hsa:5152
constant: false

metaM cit e
is: HMDB00094
is: SBO:0000247
notes: FORMULA: C6H5O7 CHARGE: -3 INCHI: InChI=1S/C6H8O7/c7-3(8)1-6(13,5(11)12)2-4(9)10/h13H,1-2H2,(H,7,8)(H,9,10)(H,11,12)/p-3 HEPATONET_1.0_ABBREVIATION: HC00153 EHMN_ABBREVIATION: C00158
type: Species
initial amount: NaN
has only substance units: false
boundary condition: false
constant: false
initial concentration: 1.0
is: CHEBI:16947
name: citrate(3-)

http://identifiers.org/biomodels.db/MODEL1310110063#_7b4f9f5d_c3df_44dc_9e48_523be34ee760
is: SBO:0000252
constant: false
has only substance units: false
type: Species
is encoded by: hsa:U37519
boundary condition: true
initial concentration: NaN
initial amount: NaN
name: _U37519_1_m

http://identifiers.org/biomodels.db/MODEL1310110063#_00102ea3_7539_41cb_a495_7a273cfe4123
boundary condition: true
initial amount: NaN
is encoded by: hsa:8883
has only substance units: false
initial concentration: NaN
is: A8MU28
name: NAE1
type: Species
is: SBO:0000252
constant: false

http://identifiers.org/biomodels.db/MODEL1310110063#_eb2dfc3b_12b1_4552_983b_8af95d55159b
name: PCYT2
boundary condition: true
is encoded by: hsa:5833
constant: false
type: Species
is: SBO:0000252
initial concentration: NaN
has only substance units: false
is: F5H8B1
initial amount: NaN

metaR r0885
kinetic law: MODEL1310110063#
is: SBO:0000185
reactant: MODEL1310110063#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (AA526438.1) or (H17063.1) or (51102.1) or (55825.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:15845418,PMID:16600197,PMID:9639574 NOTES:
product: MODEL1310110063#
fast: false
type: Reaction
is version of: http://identifiers.org/ec-code/1.3.1.38
modifier: MODEL1310110063#
name: Mitochondrial Carrier (MC) TCDB:2.A.29.2.7
reversible: true

metaR DNDPt10m
kinetic law: MODEL1310110063#
is: SBO:0000185
is described by: ECO:0000269
reactant: MODEL1310110063#
type: Reaction
name: dADP transport via dCDP antiport
fast: false
modifier: MODEL1310110063#
notes: GENE_ASSOCIATION: (60386.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:11226231 NOTES:IT
reversible: false
product: MODEL1310110063#

metaM ptth m
is: SBO:0000247
type: Species
notes: FORMULA: C11H22N2O4S CHARGE: 0 INCHI: InChI=1S/C11H22N2O4S/c1-11(2,7-14)9(16)10(17)13-4-3-8(15)12-5-6-18/h9,14,16,18H,3-7H2,1-2H3,(H,12,15)(H,13,17)/t9-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00554 EHMN_ABBREVIATION: C00831
name: pantetheine
constant: false
initial amount: NaN
boundary condition: false
is: CHEBI:16753
has only substance units: false
initial concentration: 1.0
is: HMDB03426

http://identifiers.org/biomodels.db/MODEL1310110063#_e258d384_9fbc_4863_91ed_775663388705
constant: false
has only substance units: false
type: Species
boundary condition: true
is: Q6FG42
initial concentration: NaN
is encoded by: hsa:4701
initial amount: NaN
name: NDUFA7
is: SBO:0000252

metaM cys L c
initial concentration: 1.0
name: L-cysteine
boundary condition: false
notes: FORMULA: C3H7NO2S CHARGE: 0 INCHI: InChI=1S/C3H7NO2S/c4-2(1-7)3(5)6/h2,7H,1,4H2,(H,5,6)/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00099
initial amount: NaN
is: CHEBI:17561
type: Species
is: SBO:0000247
has only substance units: false
constant: false
is: HMDB00574

metaR r2029
kinetic law: MODEL1310110063#
is described by: ECO:0000000
reversible: false
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reactant: MODEL1310110063#
type: Reaction
fast: false
is: SBO:0000185
modifier: MODEL1310110063#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.15
product: MODEL1310110063#

metaM aacoa c
is: C00332
name: Acetoacetyl-CoA
initial concentration: 1.0
type: Species
has only substance units: false
is: HMDB01484
is: SBO:0000247
boundary condition: false
constant: false
is: CHEBI:57286
notes: FORMULA: C25H36N7O18P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00282 EHMN_ABBREVIATION: C00332
initial amount: NaN

metaM co e
has only substance units: false
initial concentration: 1.0
is: SBO:0000247
initial amount: NaN
name: carbon monoxide
is: CHEBI:17245
is: HMDB01361
notes: FORMULA: CO CHARGE: 0 INCHI: InChI=1S/CO/c1-2 EHMN_ABBREVIATION: C00237
constant: false
type: Species
boundary condition: false

metaM dd3coa x
type: Species
is: SBO:0000247
is: HMDB04257
notes: FORMULA: C33H52N7O17P3S CHARGE: -4
boundary condition: false
constant: false
has only substance units: false
name: 3-dodecenoylcoa
initial concentration: 1.0
initial amount: NaN

metaM pi r
type: Species
constant: false
notes: FORMULA: HO4P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00019 EHMN_ABBREVIATION: C00009
is: C00009
name: hydrogenphosphate
is: CHEBI:43474
initial amount: NaN
initial concentration: 1.0
has only substance units: false
boundary condition: false
is: HMDB00973
is: SBO:0000247

metaR RE1796R
reactant: MODEL1310110063#
kinetic law: MODEL1310110063#
is version of: http://identifiers.org/ec-code/1.1.1.145
is: SBO:0000176
reversible: true
notes: GENE_ASSOCIATION: (3283.1) or (3284.1) SUBSYSTEM: Bile acid synthesis EC Number: 5.3.3.1 Confidence Level: 0 AUTHORS: PMID:10599696,PMID:11067870,PMID:11454857,PMID:1401999 NOTES:
modifier: MODEL1310110063#
is described by: ECO:0000000
fast: false
type: Reaction
product: MODEL1310110063#
name: RE1796

metaM his L e
is: SBO:0000247
boundary condition: false
is: CHEBI:15971
notes: FORMULA: C6H9N3O2 CHARGE: 0 INCHI: InChI=1S/C6H9N3O2/c7-5(6(10)11)1-4-2-8-3-9-4/h2-3,5H,1,7H2,(H,8,9)(H,10,11)/t5-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00133
initial amount: NaN
is: HMDB00177
constant: false
initial concentration: 1.0
has only substance units: false
name: L-histidine
type: Species

http://identifiers.org/biomodels.db/MODEL1310110063#_4a201a86_b6fd_4a24_a93c_1aee667c1a6f
initial concentration: NaN
has only substance units: false
is encoded by: hsa:4695
constant: false
is: SBO:0000252
initial amount: NaN
name: NDUFA2
type: Species
is: O43678
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110063#_ae628f2c_8fca_4afb_8ff0_a4024b2a1310
constant: false
initial amount: NaN
is: P04075
name: ALDOA
is encoded by: hsa:226
type: Species
has only substance units: false
is: SBO:0000252
boundary condition: true
initial concentration: NaN

metaR r0669
fast: false
kinetic law: MODEL1310110063#
product: MODEL1310110063#
name: (S)-3-Hydroxyisobutyryl-CoA hydro-lyase Valine, leucine and isoleucine degradation EC:4.2.1.17
type: Reaction
reversible: false
is described by: ECO:0000000
reactant: MODEL1310110063#
notes: GENE_ASSOCIATION: SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 4.2.1.17 Confidence Level: 0 AUTHORS: PMID:10671535,PMID:12467702 NOTES:
is: SBO:0000176

metaR S6TASE18ly
product: MODEL1310110063#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (2799.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.1.6.14 Confidence Level: 4 AUTHORS: PMID:3196333,PMID:3689314,PMID:3689315 NOTES:NCD
fast: false
name: N-acetylglucosamine-6-sulfatase, lysosomal
reactant: MODEL1310110063#
reversible: true
is: SBO:0000176
kinetic law: MODEL1310110063#
type: Reaction
is version of: http://identifiers.org/ec-code/3.1.6.14
modifier: MODEL1310110063#

metaR RTOTALt
fast: false
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:14598172 NOTES:
name: RTOTAL transport
product: MODEL1310110063#
type: Reaction
is described by: ECO:0000000
is: SBO:0000185
kinetic law: MODEL1310110063#
reactant: MODEL1310110063#

metaR EX taur LPAREN e RPAREN
kinetic law: MODEL1310110063#
reactant: MODEL1310110063#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Taurine exchange
type: Reaction

metaM udp g
is: CHEBI:58223
type: Species
initial amount: NaN
initial concentration: 1.0
is: HMDB00295
constant: false
name: UDP(3-)
boundary condition: false
notes: FORMULA: C9H11N2O12P2 CHARGE: -3 INCHI: InChI=1S/C9H14N2O12P2/c12-5-1-2-11(9(15)10-5)8-7(14)6(13)4(22-8)3-21-25(19,20)23-24(16,17)18/h1-2,4,6-8,13-14H,3H2,(H,19,20)(H,10,12,15)(H2,16,17,18)/p-3/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00025 EHMN_ABBREVIATION: C00015
has only substance units: false
is: SBO:0000247

metaM citr L m
has only substance units: false
boundary condition: false
is: CHEBI:16349
name: L-citrulline
is: SBO:0000247
notes: FORMULA: C6H13N3O3 CHARGE: 0 INCHI: InChI=1S/C6H13N3O3/c7-4(5(10)11)2-1-3-9-6(8)12/h4H,1-3,7H2,(H,10,11)(H3,8,9,12)/t4-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00277
is: HMDB00904
constant: false
initial amount: NaN
initial concentration: 1.0
type: Species

metaR EX arachd LPAREN e RPAREN
kinetic law: MODEL1310110063#
reactant: MODEL1310110063#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: nC20:4 exchange
type: Reaction

metaM cit c
boundary condition: false
notes: FORMULA: C6H5O7 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00153 EHMN_ABBREVIATION: C00158
name: Citrate
initial amount: NaN
constant: false
is: CHEBI:16947
is: C00158
is: HMDB00094
has only substance units: false
type: Species
initial concentration: 1.0
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110063#_8e85bf2d_6e61_4fb2_9c26_ae019f9821ed
is: SBO:0000252
name: PIGC
initial concentration: NaN
type: Species
initial amount: NaN
is encoded by: hsa:5279
is: Q92535
constant: false
has only substance units: false
boundary condition: true

metaM prgstrn e
initial amount: NaN
initial concentration: 1.0
is: HMDB01830
boundary condition: false
constant: false
type: Species
is: CHEBI:17026
name: progesterone
has only substance units: false
is: SBO:0000247
notes: FORMULA: C21H30O2 CHARGE: 0 INCHI: InChI=1S/C21H30O2/c1-13(22)17-6-7-18-16-5-4-14-12-15(23)8-10-20(14,2)19(16)9-11-21(17,18)3/h12,16-19H,4-11H2,1-3H3/t16-,17+,18-,19-,20-,21+/m0/s1 EHMN_ABBREVIATION: C00410

metaM accoa m
initial amount: NaN
name: Acetyl-CoA
is: SBO:0000247
has only substance units: false
type: Species
is: C00024
notes: FORMULA: C23H34N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00033 EHMN_ABBREVIATION: C00024
boundary condition: false
is: CHEBI:57288
constant: false
initial concentration: 1.0
is: HMDB01206

metaM meoh e
initial concentration: 1.0
is: CHEBI:17790
is: SBO:0000247
is: HMDB01875
boundary condition: false
type: Species
initial amount: NaN
has only substance units: false
constant: false
notes: FORMULA: CH4O1 CHARGE: 0 INCHI: InChI=1S/CH4O/c1-2/h2H,1H3 HEPATONET_1.0_ABBREVIATION: HC00130 EHMN_ABBREVIATION: C00132
name: methanol

http://identifiers.org/biomodels.db/MODEL1310110063#_3fda1425_13ad_4bf6_bbee_2c835ba7b5ef
constant: false
is encoded by: hsa:2180
type: Species
name: ACSL1
initial amount: NaN
initial concentration: NaN
has only substance units: false
boundary condition: true
is: SBO:0000252
is: P33121

metaM cys L e
initial concentration: 1.0
name: L-cysteine
constant: false
has only substance units: false
notes: FORMULA: C3H7NO2S CHARGE: 0 INCHI: InChI=1S/C3H7NO2S/c4-2(1-7)3(5)6/h2,7H,1,4H2,(H,5,6)/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00099
is: HMDB00574
boundary condition: false
type: Species
is: SBO:0000247
initial amount: NaN
is: CHEBI:17561

http://identifiers.org/biomodels.db/MODEL1310110063#_ec6c25b5_528e_4eb3_ab9c_a646b76ecef3
is: SBO:0000252
constant: false
initial concentration: NaN
initial amount: NaN
boundary condition: true
has only substance units: false
name: GALK2
type: Species
is encoded by: hsa:2585

metaR SMPD4
type: Reaction
reactant: MODEL1310110063#
fast: false
name: sphingomyelinase
kinetic law: MODEL1310110063#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Sphingolipid metabolism EC Number: Confidence Level: 2 AUTHORS: PMID:12069827,PMID:9972865 NOTES:reaction details not determined - elucidated from PMID: 9972865, 12069827 NJ
is: SBO:0000176
reversible: false
product: MODEL1310110063#

metaM udpg c
is: SBO:0000247
notes: FORMULA: C15H22N2O17P2 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00038 EHMN_ABBREVIATION: C00029
is: C00029
constant: false
name: UDPglucose
has only substance units: false
boundary condition: false
is: HMDB00286
initial amount: NaN
type: Species
is: CHEBI:58367
initial concentration: 1.0

metaM CE4794 m
type: Species
constant: false
is: CHEBI:57923
is: SBO:0000247
notes: FORMULA: C33H52N7O17P3S CHARGE: -4 INCHI: InChI=1/C33H56N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-24(42)61-17-16-35-23(41)14-15-36-31(45)28(44)33(2,3)19-54-60(51,52)57-59(49,50)53-18-22-27(56-58(46,47)48)26(43)32(55-22)40-21-39-25-29(34)37-20-38-30(25)40/h8-9,20-22,26-28,32,43-44H,4-7,10-19H2,1-3H3,(H,35,41)(H,36,45)(H,49,50)(H,51,52)(H2,34,37,38)(H2,46,47,48)/p-4/b9-8-/t22-,26+,27+,28u,32-/m0/s1 EHMN_ABBREVIATION: CE4794
name: cis-6-dodecenoyl-CoA
initial concentration: 1.0
has only substance units: false
boundary condition: false
initial amount: NaN

metaM mlthf c
is: SBO:0000247
name: 5,10-Methylenetetrahydrofolate
constant: false
has only substance units: false
type: Species
boundary condition: false
is: HMDB01533
initial amount: NaN
is: CHEBI:15636
notes: FORMULA: C20H21N7O6 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00140 EHMN_ABBREVIATION: C00143
is: C00143
initial concentration: 1.0

metaR DESAT18 4
reactant: MODEL1310110063#
type: Reaction
product: MODEL1310110063#
notes: GENE_ASSOCIATION: (6319.1) SUBSYSTEM: Fatty acid synthesis EC Number: 1.14.19.1 Confidence Level: 4 AUTHORS: PMID:14967823 NOTES:for homo sapiens, noted to actually be NADH-cyt b5, using NADH at present NJ
modifier: MODEL1310110063#
is: SBO:0000176
reversible: false
is version of: http://identifiers.org/ec-code/1.14.19.1
kinetic law: MODEL1310110063#
name: stearoyl-CoA desaturase (n-C18:0CoA -> n-C18:1CoA)
is described by: ECO:0000000
fast: false

metaR HOCDACBP
kinetic law: MODEL1310110063#
product: MODEL1310110063#
reactant: MODEL1310110063#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: transport of (S)-3-Hydroxyoctadecanoyl-CoA from mitochondria into the cytosol
type: Reaction

metaM udp e
notes: FORMULA: C9H11N2O12P2 CHARGE: -3 INCHI: InChI=1S/C9H14N2O12P2/c12-5-1-2-11(9(15)10-5)8-7(14)6(13)4(22-8)3-21-25(19,20)23-24(16,17)18/h1-2,4,6-8,13-14H,3H2,(H,19,20)(H,10,12,15)(H2,16,17,18)/p-3/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00025 EHMN_ABBREVIATION: C00015
type: Species
constant: false
name: UDP(3-)
is: HMDB00295
is: SBO:0000247
has only substance units: false
boundary condition: false
initial amount: NaN
is: CHEBI:58223
initial concentration: 1.0

metaR 34HPPOR
kinetic law: MODEL1310110063#
fast: false
is described by: ECO:0000269
name: 4-Hydroxyphenylpyruvate:oxygen oxidoreductase
type: Reaction
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.13.11.27
modifier: MODEL1310110063#
notes: GENE_ASSOCIATION: (3242.1) SUBSYSTEM: Tyrosine metabolism EC Number: 1.13.11.27 Confidence Level: 4 AUTHORS: NOTES:
product: MODEL1310110063#
reactant: MODEL1310110063#
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110063#_66d91d36_ae09_4ec7_ba09_912bd78c077b
constant: false
is encoded by: hsa:5152
type: Species
name: PDE9A
has only substance units: false
is: SBO:0000252
boundary condition: true
initial amount: NaN
initial concentration: NaN

metaR GLU5Km
kinetic law: MODEL1310110063#
is version of: http://identifiers.org/ec-code/1.2.1.41
reversible: false
product: MODEL1310110063#
is: SBO:0000176
reactant: MODEL1310110063#
notes: GENE_ASSOCIATION: (5832.1) SUBSYSTEM: Urea cycle EC Number: 2.7.2.11 Confidence Level: 2 AUTHORS: PMID:10037775 NOTES:SAB m
modifier: MODEL1310110063#
type: Reaction
name: glutamate 5-kinase (m)
fast: false
is described by: ECO:0000254

metaR RE2998M
type: Reaction
is described by: ECO:0000000
is: SBO:0000176
name: RE2998
reactant: MODEL1310110063#
modifier: MODEL1310110063#
fast: false
is version of: http://identifiers.org/ec-code/1.3.3.6
product: MODEL1310110063#
reversible: false
notes: GENE_ASSOCIATION: (51.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.3.6 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:7775433 NOTES:
kinetic law: MODEL1310110063#

metaR SPH1Pte
reactant: MODEL1310110063#
is described by: ECO:0000000
kinetic law: MODEL1310110063#
product: MODEL1310110063#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:15585321 NOTES:unknown mechanism for transport, may be vesicular/caveolar/other ... intracellular transport and extracellular export mechanisms must exist - see for example: PMID: 15585321 NJ
reversible: true
name: sph1p transport
type: Reaction
fast: false
is: SBO:0000185

metaM pi g
initial amount: NaN
initial concentration: 1.0
is: SBO:0000247
name: hydrogenphosphate
type: Species
constant: false
has only substance units: false
boundary condition: false
notes: FORMULA: HO4P CHARGE: -2 INCHI: InChI=1S/H3O4P/c1-5(2,3)4/h(H3,1,2,3,4)/p-2 HEPATONET_1.0_ABBREVIATION: HC00019 EHMN_ABBREVIATION: C00009
is: CHEBI:43474
is: HMDB00973

metaR r1610
product: MODEL1310110063#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
type: Reaction
is described by: ECO:0000000
kinetic law: MODEL1310110063#
reversible: true
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is: SBO:0000185
reactant: MODEL1310110063#

metaR PYRt2p
notes: GENE_ASSOCIATION: (6566.1) or (9194.1) SUBSYSTEM: D-alanine metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:12705896,PMID:12739169,PMID:9786900 NOTES:NCD
fast: false
name: pyruvate peroxisomal transport via proton symport
type: Reaction
modifier: MODEL1310110063#
product: MODEL1310110063#
reactant: MODEL1310110063#
reversible: true
is: SBO:0000185
kinetic law: MODEL1310110063#
is described by: ECO:0000269

metaM arachcoa m
constant: false
boundary condition: false
initial amount: NaN
has only substance units: false
type: Species
is: HMDB04258
notes: FORMULA: C41H70N7O17P3S CHARGE: -4 INCHI: InChI=1S/C41H74N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-32(50)69-25-24-43-31(49)22-23-44-39(53)36(52)41(2,3)27-62-68(59,60)65-67(57,58)61-26-30-35(64-66(54,55)56)34(51)40(63-30)48-29-47-33-37(42)45-28-46-38(33)48/h28-30,34-36,40,51-52H,4-27H2,1-3H3,(H,43,49)(H,44,53)(H,57,58)(H,59,60)(H2,42,45,46)(H2,54,55,56)/t30-,34-,35-,36+,40-/m1/s1 EHMN_ABBREVIATION: C02041
is: CHEBI:15527
is: SBO:0000247
initial concentration: 1.0
name: arachidyl coenzyme A

http://identifiers.org/biomodels.db/MODEL1310110063#_b72ed1bd_90bd_4f57_8ff0_97628c973ec9
constant: false
name: HPRT1
type: Species
initial concentration: NaN
is: SBO:0000252
boundary condition: true
is: P00492
has only substance units: false
initial amount: NaN
is encoded by: hsa:3251

metaR r0122
is: SBO:0000176
type: Reaction
product: MODEL1310110063#
notes: GENE_ASSOCIATION: SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: 2.7.1.40 Confidence Level: 0 AUTHORS: PMID:1009117,PMID:7154942 NOTES:
fast: false
name: GTP:pyruvate O2-phosphotransferase Purine metabolism EC:2.7.1.40
is described by: ECO:0000000
reactant: MODEL1310110063#
reversible: false
kinetic law: MODEL1310110063#

metaM accoa n
has only substance units: false
name: acetyl-CoA(4-)
initial amount: NaN
notes: FORMULA: C23H34N7O17P3S CHARGE: -4 INCHI: InChI=1S/C23H38N7O17P3S/c1-12(31)51-7-6-25-14(32)4-5-26-21(35)18(34)23(2,3)9-44-50(41,42)47-49(39,40)43-8-13-17(46-48(36,37)38)16(33)22(45-13)30-11-29-15-19(24)27-10-28-20(15)30/h10-11,13,16-18,22,33-34H,4-9H2,1-3H3,(H,25,32)(H,26,35)(H,39,40)(H,41,42)(H2,24,27,28)(H2,36,37,38)/p-4/t13-,16-,17-,18+,22-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00033 EHMN_ABBREVIATION: C00024
initial concentration: 1.0
is: HMDB01206
type: Species
is: CHEBI:57288
boundary condition: false
is: SBO:0000247
constant: false

http://identifiers.org/biomodels.db/MODEL1310110063#_c2b76223_9682_45d7_bb2e_30a888d0fc6f
boundary condition: true
has part: P00338
is encoded by: hsa:3945
type: Species
is encoded by: hsa:3939
constant: false
initial concentration: NaN
name: LDHA:LDHB
is: SBO:0000297
has part: P07195
initial amount: NaN
has only substance units: false

metaR GALASE4ly
is version of: http://identifiers.org/ec-code/3.4.16.5
product: MODEL1310110063#
reactant: MODEL1310110063#
is version of: http://identifiers.org/ec-code/3.2.1.23
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) or (5476.1) and (2720.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.23 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD
is version of: http://identifiers.org/ec-code/3.1.6.4
name: beta-galactosidase, lysosomal
modifier: MODEL1310110063#
type: Reaction
fast: false
is described by: ECO:0000000
is: SBO:0000176
kinetic law: MODEL1310110063#
is version of: http://identifiers.org/ec-code/3.2.1.18
reversible: false

metaM ksii core2 deg2 l
name: keratan sulfate II (core 2-linked), degradation product 2
is: CHEBI:12936
constant: false
initial amount: NaN
has only substance units: false
is: SBO:0000247
boundary condition: false
initial concentration: 1.0
notes: FORMULA: C70H114N5O56S2X CHARGE: -2
is: HMDB00143
type: Species

metaR ASNtm
is described by: ECO:0000000
reactant: MODEL1310110063#
name: L-asparagine transport, mitochondrial
reversible: false
product: MODEL1310110063#
kinetic law: MODEL1310110063#
is: SBO:0000185
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: NOTES:TDV
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110063#_2b07d60e_b0e1_43d6_8fcd_4b5514ac9b44
constant: false
is encoded by: hsa:2184
has only substance units: false
name: FAH
type: Species
boundary condition: true
initial amount: NaN
is: P16930
initial concentration: NaN
is: SBO:0000252

metaM udp c
name: UDP
notes: FORMULA: C9H11N2O12P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00025 EHMN_ABBREVIATION: C00015
is: C00015
is: HMDB00295
initial concentration: 1.0
type: Species
boundary condition: false
is: CHEBI:58223
constant: false
is: SBO:0000247
has only substance units: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110063#_a2512617_76bb_48d4_b946_e17661101ebd
is: SBO:0000252
boundary condition: true
has only substance units: false
constant: false
type: Species
is encoded by: hsa:23600
name: AMACR
initial concentration: NaN
is: Q3KT79
initial amount: NaN

metaR r0236
notes: GENE_ASSOCIATION: (AI640625.1) or (51733.1) SUBSYSTEM: Pyrimidine catabolism EC Number: 1.3.1.1 Confidence Level: 0 AUTHORS: PMID:1260500 NOTES:
kinetic law: MODEL1310110063#
product: MODEL1310110063#
name: 5,6-Dihydrouracil:NAD+ oxidoreductase Pyrimidine metabolism EC:1.3.1.1
is: SBO:0000176
reactant: MODEL1310110063#
reversible: true
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/3.5.1.6
type: Reaction
fast: false
modifier: MODEL1310110063#

metaM meoh c
constant: false
name: methanol
boundary condition: false
initial amount: NaN
is: SBO:0000247
is: CHEBI:17790
notes: FORMULA: CH4O1 CHARGE: 0 INCHI: InChI=1S/CH4O/c1-2/h2H,1H3 HEPATONET_1.0_ABBREVIATION: HC00130 EHMN_ABBREVIATION: C00132
is: HMDB01875
initial concentration: 1.0
has only substance units: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110063#_f378c44f_70f2_4de4_a902_bd973c4679cd
boundary condition: true
is encoded by: hsa:30
initial amount: NaN
is: Q96CA6
has only substance units: false
is: SBO:0000252
name: ACAA1
constant: false
type: Species
initial concentration: NaN

metaR DESAT18 6
notes: GENE_ASSOCIATION: (9415.1) SUBSYSTEM: Fatty acid synthesis EC Number: 1.14.99.25 Confidence Level: 4 AUTHORS: NOTES:for homo sapiens, noted to actually be NADH-cyt b5, using NADH at present NJ
type: Reaction
reversible: false
is: SBO:0000176
modifier: MODEL1310110063#
is described by: ECO:0000269
name: fatty acyl-CoA desaturase (n-C18:1CoA -> n-C18:2CoA)
product: MODEL1310110063#
reactant: MODEL1310110063#
kinetic law: MODEL1310110063#
fast: false

metaM tetdece1crn e
is: HMDB02014
notes: FORMULA: C21H39NO4 CHARGE: 0
name: tetradecenoyl carnitine
type: Species
is: SBO:0000247
constant: false
boundary condition: false
initial amount: NaN
initial concentration: 1.0
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110063#_860e00d5_aa49_4b1e_a017_e0e7196a186e
is: P11908
boundary condition: true
is encoded by: hsa:5634
name: PRPS2
has only substance units: false
initial amount: NaN
type: Species
initial concentration: NaN
is: SBO:0000252
constant: false

metaM gluside hs r
type: Species
notes: FORMULA: C24H46NO7FULLRCO CHARGE: 0 EHMN_ABBREVIATION: C01190
initial amount: NaN
initial concentration: 1.0
constant: false
boundary condition: false
has only substance units: false
is: CHEBI:18368
is: SBO:0000247
name: D-glucosyl-N-acylsphingosine

metaR FAOXC81C61m
kinetic law: MODEL1310110063#
product: MODEL1310110063#
reactant: MODEL1310110063#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C8:1-->C6:1)m
type: Reaction

metaM gdpmann c
has only substance units: false
is: SBO:0000247
boundary condition: false
initial concentration: 1.0
constant: false
type: Species
initial amount: NaN
name: GDP-alpha-D-mannose(2-)
is: HMDB01163
notes: FORMULA: C16H23N5O16P2 CHARGE: -2 INCHI: InChI=1S/C16H25N5O16P2/c17-16-19-12-6(13(28)20-16)18-3-21(12)14-10(26)8(24)5(34-14)2-33-38(29,30)37-39(31,32)36-15-11(27)9(25)7(23)4(1-22)35-15/h3-5,7-11,14-15,22-27H,1-2H2,(H,29,30)(H,31,32)(H3,17,19,20,28)/p-2/t4-,5-,7-,8-,9+,10-,11+,14-,15-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00098 EHMN_ABBREVIATION: C00096
is: CHEBI:57527

http://identifiers.org/biomodels.db/MODEL1310110063#_0d858039_92dd_4060_ad24_6c8a2bfbdf2a
constant: false
type: Species
initial concentration: NaN
boundary condition: true
is encoded by: hsa:175
is: P20933
name: AGA
is: SBO:0000252
initial amount: NaN
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110063#_41dc2f12_550b_4175_bcb8_673fc2476f5c
is: SBO:0000252
name: SLC38A5
type: Species
has only substance units: false
initial concentration: NaN
boundary condition: true
is: Q8WUX1
is encoded by: hsa:92745
constant: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110063#_2b493a96_ddd8_4027_9b85_eaa8c17450c8
initial amount: NaN
has only substance units: false
is: SBO:0000252
type: Species
is encoded by: hsa:AI915649
constant: false
initial concentration: NaN
boundary condition: true
name: _AI915649_1_c

metaR HPYRDC
name: hydroxypyruvate decarboxylase
reactant: MODEL1310110063#
type: Reaction
reversible: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Glyoxylate and dicarboxylate metabolism EC Number: 4.1.1.40 Confidence Level: 2 AUTHORS: PMID:3778681 NOTES:NCD
fast: false
kinetic law: MODEL1310110063#
product: MODEL1310110063#
is: SBO:0000176
is described by: ECO:0000000

metaR DADNt4
reversible: true
is: SBO:0000185
fast: false
type: Reaction
reactant: MODEL1310110063#
product: MODEL1310110063#
name: deoxyadenosine transport via diffusion
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10899995 NOTES:
is described by: ECO:0000000
kinetic law: MODEL1310110063#

metaM orn m
has only substance units: false
name: Ornithine
notes: FORMULA: C5H13N2O2 CHARGE: 1
type: Species
boundary condition: false
initial concentration: 1.0
is: SBO:0000247
initial amount: NaN
is: HMDB00214
is: C01602
is: CHEBI:46912
constant: false

http://identifiers.org/biomodels.db/MODEL1310110063#_9984ca57_4f27_428e_9431_b8f14ce880bc
name: SLC24A1
initial concentration: NaN
is: B4DUG1
initial amount: NaN
boundary condition: true
is encoded by: hsa:9187
has only substance units: false
constant: false
type: Species
is: SBO:0000252

metaM ivcrn e
is: SBO:0000247
initial concentration: 1.0
is: HMDB00688
initial amount: NaN
boundary condition: false
name: isovaleryl carnitine
notes: FORMULA: C12H23NO4 CHARGE: 0
has only substance units: false
constant: false
type: Species

metaR FACOAL181i
notes: GENE_ASSOCIATION: (2180.1) or (2181.2) or (2181.1) SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 4 AUTHORS: NOTES:TV catalyzed by acyl-CoA synthetases
fast: false
reversible: false
reactant: MODEL1310110063#
modifier: MODEL1310110063#
is described by: ECO:0000269
product: MODEL1310110063#
name: C181 fatty acid activation
is version of: http://identifiers.org/ec-code/6.2.1.3
is: SBO:0000176
type: Reaction
kinetic law: MODEL1310110063#

metaR r1612
type: Reaction
fast: false
product: MODEL1310110063#
is described by: ECO:0000000
is: SBO:0000185
reversible: true
kinetic law: MODEL1310110063#
reactant: MODEL1310110063#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
notes: GENE_ASSOCIATION: (19.1) or (AL038231.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
modifier: MODEL1310110063#

http://identifiers.org/biomodels.db/MODEL1310110063#_47427129_deac_42d6_a0ef_d228c3b91a88
is: O95045
constant: false
name: UPP2
initial concentration: NaN
type: Species
has only substance units: false
boundary condition: true
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:151531

http://identifiers.org/biomodels.db/MODEL1310110063#_ccd90a67_dffb_4cb8_b08a_93cbb17414c0
initial amount: NaN
boundary condition: true
is: SBO:0000252
name: PDE6A
is: P16499
initial concentration: NaN
has only substance units: false
type: Species
constant: false
is encoded by: hsa:5145

http://identifiers.org/biomodels.db/MODEL1310110063#_80f6227e_9dc0_45c4_98ec_030e3dd23f63
initial concentration: NaN
is: SBO:0000252
initial amount: NaN
name: DYLX2
boundary condition: true
is encoded by: hsa:9856
type: Species
has only substance units: false
constant: false
is: F5H123

metaR ATP1ter
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: NOTES:NCD
fast: false
is: SBO:0000185
kinetic law: MODEL1310110063#
reversible: true
reactant: MODEL1310110063#
name: ADP/ATP transporter, endoplasmic reticulum
is described by: ECO:0000000
type: Reaction
product: MODEL1310110063#

metaM rbt e
is: SBO:0000247
name: D-ribitol
notes: FORMULA: C5H12O5 CHARGE: 0 INCHI: InChI=1S/C5H12O5/c6-1-3(8)5(10)4(9)2-7/h3-10H,1-2H2/t3-,4+,5- HEPATONET_1.0_ABBREVIATION: HC00380
has only substance units: false
initial concentration: 1.0
boundary condition: false
type: Species
is: HMDB00508
is: CHEBI:15963
constant: false
initial amount: NaN

metaR r1851
kinetic law: MODEL1310110063#
reversible: false
modifier: MODEL1310110063#
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is: SBO:0000185
type: Reaction
is described by: ECO:0000000
reactant: MODEL1310110063#
fast: false
name: Y+LAT2 Utilized transport
product: MODEL1310110063#

metaR PYRt2m
notes: GENE_ASSOCIATION: (6566.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:6987111 NOTES:IF changed name from "tm" to "t2m" - NCD
is described by: ECO:0000000
reversible: true
fast: false
kinetic law: MODEL1310110063#
reactant: MODEL1310110063#
product: MODEL1310110063#
type: Reaction
name: pyruvate mitochondrial transport via proton symport
modifier: MODEL1310110063#
is: SBO:0000185

metaR FAOXC184x
kinetic law: MODEL1310110063#
product: MODEL1310110063#
reactant: MODEL1310110063#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: isomerization(C18:4)x
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110063#_2bda1af9_624a_4d29_be27_1c87de00febb
is encoded by: hsa:157506
boundary condition: true
is: SBO:0000252
constant: false
initial amount: NaN
name: RDH10
initial concentration: NaN
is: Q8IZV5
type: Species
has only substance units: false

metaR r1611
is described by: ECO:0000000
reversible: true
product: MODEL1310110063#
fast: false
kinetic law: MODEL1310110063#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
type: Reaction
reactant: MODEL1310110063#

http://identifiers.org/biomodels.db/MODEL1310110063#_f3dc1202_9ef1_4e66_9d71_3ef720c5a409
boundary condition: true
initial amount: NaN
type: Species
constant: false
has only substance units: false
initial concentration: NaN
name: PIGC
is encoded by: hsa:5279
is: SBO:0000252

metaR FAOXC142C122x
kinetic law: MODEL1310110063#
product: MODEL1310110063#
reactant: MODEL1310110063#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C14:2-->C12:2)x
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110063#_8c143dad_081b_4e0a_aa74_6ee526b14927
type: Species
constant: false
is: SBO:0000252
name: _U37519_1_c
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:U37519
boundary condition: true
has only substance units: false

metaR DM n5m2masn g
kinetic law: MODEL1310110063#
reactant: MODEL1310110063#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 0 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: false
name: DM n5m2masn(g)
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110063#_5b646514_c3a5_4669_840a_68f5587e7627
is encoded by: hsa:10317
type: Species
has only substance units: false
constant: false
initial amount: NaN
name: B3GALT5
is: SBO:0000252
initial concentration: NaN
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110063#_84db8838_641e_4419_891a_8df71f88c7e2
is: SBO:0000252
constant: false
name: FUT8
initial amount: NaN
has only substance units: false
is: B4DFS7
is encoded by: hsa:2530
type: Species
boundary condition: true
initial concentration: NaN

metaR FOAXC122C101x
kinetic law: MODEL1310110063#
product: MODEL1310110063#
reactant: MODEL1310110063#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C12:2-->C10:1)x
type: Reaction

metaM dlnlcg e
is: HMDB02925
is: SBO:0000247
initial amount: NaN
initial concentration: 1.0
notes: FORMULA: C20H33O2 CHARGE: -1 INCHI: InChI=1S/C20H34O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20(21)22/h6-7,9-10,12-13H,2-5,8,11,14-19H2,1H3,(H,21,22)/b7-6-,10-9-,13-12-
name: dihomo-gamma-linolenic acid (n-6)
boundary condition: false
is: CHEBI:53486
constant: false
has only substance units: false
type: Species

metaM prostgf2 e
constant: false
is: CHEBI:57404
boundary condition: false
type: Species
initial concentration: 1.0
has only substance units: false
notes: FORMULA: C20H33O5 CHARGE: -1 INCHI: InChI=1S/C20H34O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h4,7,12-13,15-19,21-23H,2-3,5-6,8-11,14H2,1H3,(H,24,25)/p-1/b7-4-,13-12+/t15-,16+,17+,18-,19+/m0/s1 EHMN_ABBREVIATION: C00639
initial amount: NaN
is: HMDB01139
is: SBO:0000247
name: prostaglandin F2alpha(1-)

metaM tetdece1crn c
notes: FORMULA: C21H39NO4 CHARGE: 0
is: HMDB02014
boundary condition: false
is: SBO:0000247
name: tetradecenoyl carnitine
initial concentration: 1.0
type: Species
constant: false
has only substance units: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110063#_efa35f8f_376b_4de6_a7dc_40301a9ad44b
has only substance units: false
is: SBO:0000252
name: ALG3
is encoded by: hsa:10195
boundary condition: true
initial amount: NaN
type: Species
initial concentration: NaN
constant: false

metaR r0558
is version of: http://identifiers.org/ec-code/1.5.1.3
product: MODEL1310110063#
is: SBO:0000176
kinetic law: MODEL1310110063#
reactant: MODEL1310110063#
type: Reaction
reversible: true
notes: GENE_ASSOCIATION: (1719.1) or (HG2846-HT2983.1) SUBSYSTEM: Unassigned EC Number: 1.2.1.29 Confidence Level: 0 AUTHORS: PMID:11569919,PMID:16143537 NOTES:
name: Gentisate aldehyde:NAD+ oxidoreductase Tyrosine metabolism EC:1.2.1.29
fast: false
modifier: MODEL1310110063#
is described by: ECO:0000000

metaM cit m
has only substance units: false
is: C00158
initial amount: NaN
constant: false
is: CHEBI:16947
is: SBO:0000247
name: Citrate
is: HMDB00094
boundary condition: false
initial concentration: 1.0
notes: FORMULA: C6H5O7 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00153 EHMN_ABBREVIATION: C00158
type: Species

metaR ASNTHRNaEx
product: MODEL1310110063#
reversible: false
type: Reaction
kinetic law: MODEL1310110063#
name: L-threonine/L-asparagine Na-dependent exchange (Asn-L in)
is: SBO:0000185
is described by: ECO:0000269
reactant: MODEL1310110063#
fast: false
notes: GENE_ASSOCIATION: (6510.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14530974 NOTES:SAB see Kanai and Hediger 2004 (2003), PMID 14530974
modifier: MODEL1310110063#

metaR FAOXC102C101x
kinetic law: MODEL1310110063#
product: MODEL1310110063#
reactant: MODEL1310110063#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C10:2-->C10:1)x
type: Reaction

metaR r1614
product: MODEL1310110063#
type: Reaction
reversible: true
is: SBO:0000185
is described by: ECO:0000000
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
modifier: MODEL1310110063#
kinetic law: MODEL1310110063#
fast: false
notes: GENE_ASSOCIATION: (19.1) or (AL038231.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reactant: MODEL1310110063#

metaR KHte
product: MODEL1310110063#
kinetic law: MODEL1310110063#
reactant: MODEL1310110063#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
type: Reaction
is described by: ECO:0000134
fast: false
reversible: true
name: KHte

metaM HC02203 e
name: prostaglandin-a2
initial amount: NaN
notes: FORMULA: C20H29O4 CHARGE: -1 INCHI: InChI=1S/C20H30O4/c1-2-3-6-9-17(21)14-12-16-13-15-19(22)18(16)10-7-4-5-8-11-20(23)24/h4,7,12-18,21H,2-3,5-6,8-11H2,1H3,(H,23,24)/b7-4-,14-12+/t16-,17-,18+/m0/s1 EHMN_ABBREVIATION: C05953
type: Species
is: SBO:0000247
boundary condition: false
constant: false
has only substance units: false
is: CHEBI:27820
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110063#_e0bca0bb_0320_4c9e_aac2_e172e2413fb7
type: Species
constant: false
has only substance units: false
is encoded by: hsa:1327
is: SBO:0000252
initial concentration: NaN
name: COX4I1
initial amount: NaN
is: P13073
boundary condition: true

metaM rbt c
constant: false
has only substance units: false
initial concentration: 1.0
initial amount: NaN
boundary condition: false
is: HMDB00508
is: CHEBI:15963
type: Species
name: D-ribitol
notes: FORMULA: C5H12O5 CHARGE: 0 INCHI: InChI=1S/C5H12O5/c6-1-3(8)5(10)4(9)2-7/h3-10H,1-2H2/t3-,4+,5- HEPATONET_1.0_ABBREVIATION: HC00380
is: SBO:0000247

metaM tchola c
is: SBO:0000247
name: taurocholic acid
initial amount: NaN
initial concentration: 1.0
notes: FORMULA: C26H45NO7S CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC01378 EHMN_ABBREVIATION: C05122
is: CHEBI:36257
has only substance units: false
boundary condition: false
type: Species
constant: false
is: HMDB00036

metaM uri e
constant: false
is: CHEBI:16704
is: C00299
name: Uridine
boundary condition: false
is: SBO:0000247
initial concentration: 1.0
has only substance units: false
is: HMDB00296
notes: FORMULA: C9H12N2O6 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00259 EHMN_ABBREVIATION: C00299
initial amount: NaN
type: Species

http://identifiers.org/biomodels.db/MODEL1310110063#_42b488eb_cfa1_4516_b13f_174df4cbfae3
constant: false
type: Species
has only substance units: false
initial concentration: NaN
is encoded by: hsa:6487
is: Q5T4W8
boundary condition: true
initial amount: NaN
name: ST3GAL3
is: SBO:0000252

metaM arab L c
notes: FORMULA: C5H10O5 CHARGE: 0
name: L-arabinose
is: CHEBI:30849
initial concentration: 1.0
constant: false
boundary condition: false
type: Species
is: HMDB00646
has only substance units: false
initial amount: NaN
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110063#_b2f991fc_7064_43bd_83f0_691e6c9f23e1
has part: P56381
is encoded by: hsa:514
name: ATP5A1:ATP5B:ATP5C1:ATP5D:ATP5E
has only substance units: false
type: Species
constant: false
is encoded by: hsa:513
initial amount: NaN
is encoded by: hsa:506
is encoded by: hsa:509
has part: P06576
is encoded by: hsa:498
has part: A8K092
boundary condition: true
has part: P36542
is: SBO:0000297
has part: P30049
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110063#_729bc27a_271a_43a8_9049_46aea69d9071
initial amount: NaN
has only substance units: false
constant: false
name: ST3GAL1
is encoded by: hsa:6482
boundary condition: true
type: Species
is: SBO:0000252
initial concentration: NaN

metaM accoa r
constant: false
has only substance units: false
is: SBO:0000247
is: CHEBI:57288
boundary condition: false
type: Species
notes: FORMULA: C23H34N7O17P3S CHARGE: -4 INCHI: InChI=1S/C23H38N7O17P3S/c1-12(31)51-7-6-25-14(32)4-5-26-21(35)18(34)23(2,3)9-44-50(41,42)47-49(39,40)43-8-13-17(46-48(36,37)38)16(33)22(45-13)30-11-29-15-19(24)27-10-28-20(15)30/h10-11,13,16-18,22,33-34H,4-9H2,1-3H3,(H,25,32)(H,26,35)(H,39,40)(H,41,42)(H2,24,27,28)(H2,36,37,38)/p-4/t13-,16-,17-,18+,22-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00033 EHMN_ABBREVIATION: C00024
initial concentration: 1.0
is: HMDB01206
name: acetyl-CoA(4-)
initial amount: NaN

metaR r1613
is described by: ECO:0000000
reversible: true
fast: false
modifier: MODEL1310110063#
product: MODEL1310110063#
kinetic law: MODEL1310110063#
is: SBO:0000185
notes: GENE_ASSOCIATION: (19.1) or (AL038231.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
type: Reaction
reactant: MODEL1310110063#

metaR r0559
fast: false
name: aldehyde oxidase Tyrosine metabolism EC:1.2.3.1
type: Reaction
reversible: true
product: MODEL1310110063#
modifier: MODEL1310110063#
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/1.5.1.3
kinetic law: MODEL1310110063#
notes: GENE_ASSOCIATION: (1719.1) or (HG2846-HT2983.1) SUBSYSTEM: Unassigned EC Number: 1.2.3.1 Confidence Level: 0 AUTHORS: PMID:11569919,PMID:16143537 NOTES:
reactant: MODEL1310110063#
is: SBO:0000176

metaM f6p c
boundary condition: false
has only substance units: false
is: C00085
is: CHEBI:57579
initial concentration: 1.0
is: HMDB00124
initial amount: NaN
type: Species
name: D-Fructose 6-phosphate
constant: false
is: http://identifiers.org/pubchem.compound/3385
is: SBO:0000247

metaR FAOXC141C141OHm
kinetic law: MODEL1310110063#
product: MODEL1310110063#
reactant: MODEL1310110063#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C14:1-->C14:1OH)m
type: Reaction

metaR RE2655R
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Vitamin A metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:9647871 NOTES:
is: SBO:0000176
product: MODEL1310110063#
type: Reaction
reactant: MODEL1310110063#
name: RE2655
reversible: true
fast: false
kinetic law: MODEL1310110063#

http://identifiers.org/biomodels.db/MODEL1310110063#_2f75ee0a_00c1_4122_aa5d_ac7325509208
has only substance units: false
is: B7Z4Y6
constant: false
initial concentration: NaN
is encoded by: hsa:249
boundary condition: true
initial amount: NaN
name: ALPL
type: Species
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110063#_005039a5_cd61_4467_a2e2_6177b2e5bdcc
is encoded by: hsa:113235
initial concentration: NaN
is: Q96NT5
initial amount: NaN
name: SLC46A1
constant: false
is: SBO:0000252
boundary condition: true
type: Species
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110063#_6e32fc8e_a3fb_458d_b9ba_d8d5c8b5584c
name: EHHADH:ACAA1:ACOX1
initial concentration: NaN
constant: false
has part: Q9NY65
type: Species
initial amount: NaN
boundary condition: true
is encoded by: hsa:1962
is: SBO:0000297
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110063#_2dc39e60_ebd1_4758_a6cc_6e42dc3df37d
boundary condition: true
name: ACOX3
is: SBO:0000252
initial concentration: NaN
initial amount: NaN
is: O15254
type: Species
is encoded by: hsa:8310
has only substance units: false
constant: false

http://identifiers.org/biomodels.db/MODEL1310110063#_523900ee_a924_472e_90d4_2ff702e7b306
type: Species
boundary condition: true
is: SBO:0000252
name: DPAGT1
has only substance units: false
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:1798
constant: false

metaM pi m
name: hydrogenphosphate
constant: false
notes: FORMULA: HO4P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00019 EHMN_ABBREVIATION: C00009
has only substance units: false
boundary condition: false
is: CHEBI:43474
initial amount: NaN
is: HMDB00973
initial concentration: 1.0
is: C00009
is: SBO:0000247
type: Species

metaR PYRt2r
notes: GENE_ASSOCIATION: (9123.1) or (9194.1) or (6566.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10510291,PMID:11101640,PMID:12739169,PMID:7835905,PMID:8476015,PMID:9425115,PMID:9508842,PMID:9649795,PMID:9786900,PMID:9824713 NOTES:JLR
fast: false
modifier: MODEL1310110063#
type: Reaction
reactant: MODEL1310110063#
is: SBO:0000185
name: pyruvate reversible transport via proton symport
product: MODEL1310110063#
is described by: ECO:0000269
reversible: true
kinetic law: MODEL1310110063#

metaR C5DCe
kinetic law: MODEL1310110063#
product: MODEL1310110063#
reactant: MODEL1310110063#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of glutaryl carnitine into the extra cellular fluid
type: Reaction

metaM prostgf2 c
initial concentration: 1.0
is: CHEBI:57404
is: HMDB01139
is: SBO:0000247
notes: FORMULA: C20H33O5 CHARGE: -1 INCHI: InChI=1S/C20H34O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h4,7,12-13,15-19,21-23H,2-3,5-6,8-11,14H2,1H3,(H,24,25)/p-1/b7-4-,13-12+/t15-,16+,17+,18-,19+/m0/s1 EHMN_ABBREVIATION: C00639
boundary condition: false
initial amount: NaN
name: prostaglandin F2alpha(1-)
type: Species
constant: false
has only substance units: false

metaR r0556
is described by: ECO:0000000
modifier: MODEL1310110063#
reversible: true
fast: false
kinetic law: MODEL1310110063#
is: SBO:0000176
product: MODEL1310110063#
name: succinyl-CoA:enzyme N6-(dihydrolipoyl)lysine S-succinyltransferase Citrate cycle (TCA cycle) EC:2.3.1.61
reactant: MODEL1310110063#
is version of: http://identifiers.org/ec-code/1.14.19.1
type: Reaction
notes: GENE_ASSOCIATION: (AF116616.1) or (PRO1933.1) or (6319.1) or (79966.1) SUBSYSTEM: Unassigned EC Number: 2.3.1.61 Confidence Level: 0 AUTHORS: PMID:8076640,PMID:9620315 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110063#_6b570417_0f9b_4865_83f2_b2add2c9da0d
name: ACSS1
boundary condition: true
is: Q9NUB1
is encoded by: hsa:84532
has only substance units: false
constant: false
initial concentration: NaN
type: Species
initial amount: NaN
is: SBO:0000252

metaR r0330
type: Reaction
product: MODEL1310110063#
reversible: false
name: 5,6-Dihydrothymine:NAD+ oxidoreductase Pyrimidine metabolism EC:1.3.1.1
modifier: MODEL1310110063#
notes: GENE_ASSOCIATION: (6576.1) SUBSYSTEM: Pyrimidine catabolism EC Number: 1.3.1.1 Confidence Level: 0 AUTHORS: PMID:1260500,PMID:8615641 NOTES:
is: SBO:0000176
reactant: MODEL1310110063#
kinetic law: MODEL1310110063#
fast: false
is described by: ECO:0000000

metaR r1616
product: MODEL1310110063#
is described by: ECO:0000000
reversible: true
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reactant: MODEL1310110063#
fast: false
modifier: MODEL1310110063#
kinetic law: MODEL1310110063#
notes: GENE_ASSOCIATION: (19.1) or (AL038231.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
type: Reaction
is: SBO:0000185

metaR CSNAT2x
type: Reaction
notes: GENE_ASSOCIATION: (54677.1) or (1384.2) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.7 Confidence Level: 4 AUTHORS: PMID:15464416,PMID:7829107 NOTES:NJ
reactant: MODEL1310110063#
product: MODEL1310110063#
reversible: true
is: SBO:0000176
modifier: MODEL1310110063#
name: carnitine dimethyl nonanoyl transferase, revsible, peroxisomal
is version of: http://identifiers.org/ec-code/2.3.1.137
fast: false
kinetic law: MODEL1310110063#
is version of: http://identifiers.org/ec-code/2.3.1.7
is described by: ECO:0000269

metaR ADNt
notes: GENE_ASSOCIATION: (3177.1) or (2030.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10722669,PMID:12838422 NOTES:IT
product: MODEL1310110063#
type: Reaction
kinetic law: MODEL1310110063#
modifier: MODEL1310110063#
reactant: MODEL1310110063#
is described by: ECO:0000269
fast: false
name: adenosine facilated transport in cytosol
is: SBO:0000185
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110063#_03240ba7_3b9f_4588_8fb3_12577d6ef6e9
is: SBO:0000252
constant: false
boundary condition: true
is: Q96QD8
type: Species
is encoded by: hsa:54407
name: SLC38A2
initial amount: NaN
has only substance units: false
initial concentration: NaN

metaM uri c
initial amount: NaN
name: Uridine
is: CHEBI:16704
constant: false
boundary condition: false
is: C00299
initial concentration: 1.0
has only substance units: false
is: SBO:0000247
notes: FORMULA: C9H12N2O6 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00259 EHMN_ABBREVIATION: C00299
is: HMDB00296
type: Species

metaM arab L e
notes: FORMULA: C5H10O5 CHARGE: 0
name: L-arabinose
initial concentration: 1.0
constant: false
is: HMDB00646
boundary condition: false
type: Species
initial amount: NaN
is: SBO:0000247
is: CHEBI:30849
has only substance units: false

metaR SARCStm
reactant: MODEL1310110063#
is: SBO:0000185
name: Sarcosine transport (mitochondrial)
type: Reaction
reversible: false
is described by: ECO:0000000
product: MODEL1310110063#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 1 AUTHORS: NOTES:MM
fast: false
kinetic law: MODEL1310110063#

http://identifiers.org/biomodels.db/MODEL1310110063#_26063e6a_7c79_4ec2_be46_a3f2425a0fe2
boundary condition: true
is: O95395
is: SBO:0000252
initial amount: NaN
name: GCNT3
constant: false
has only substance units: false
type: Species
is encoded by: hsa:9245
initial concentration: NaN

metaR FAOXC225C226m
kinetic law: MODEL1310110063#
product: MODEL1310110063#
reactant: MODEL1310110063#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C22:5-->C22:6)m
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110063#_9e2376a9_94f8_45aa_886e_e84ec19bcac1
is encoded by: hsa:85365
initial amount: NaN
has only substance units: false
constant: false
type: Species
boundary condition: true
is: Q9H553
is: SBO:0000252
name: ALG2
initial concentration: NaN

metaR HTDCACBP
kinetic law: MODEL1310110063#
product: MODEL1310110063#
reactant: MODEL1310110063#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: transport of (S)-3-Hydroxytetradecanoyl-CoA from mitochondria into the cytosol
type: Reaction

metaR FRDPtc
name: lipid, flip-flop intracellular transport
is: SBO:0000185
kinetic law: MODEL1310110063#
type: Reaction
is described by: ECO:0000000
reactant: MODEL1310110063#
fast: false
product: MODEL1310110063#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: PMID:12840657 NOTES:cholesterol precursor, transport by "diffusion" -> actually beleived to be flip-flop mechanism (PMID: 12840657). See also Krisans (PMID: 14713247, PMID: 12121718) for synthesis of cholesterol pathway (why FRDP needs to be transported between ER and peroxisome) NJ
reversible: true

metaR NCKt
name: Na+/Ca2+-K+ exchange
modifier: MODEL1310110063#
product: MODEL1310110063#
reactant: MODEL1310110063#
reversible: true
notes: GENE_ASSOCIATION: (123041.2) or (57419.1) or (9187.1) or (123041.3) or (25769.1) or (123041.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10484410,PMID:10662833,PMID:11294880,PMID:12379639,PMID:14770312,PMID:9478004 NOTES:NCD
fast: false
is: SBO:0000185
kinetic law: MODEL1310110063#
is described by: ECO:0000269
type: Reaction

metaR SPC HSt
reactant: MODEL1310110063#
fast: false
type: Reaction
name: sphingosylphosphorylcholine transport (diffusion)
reversible: true
product: MODEL1310110063#
is: SBO:0000185
kinetic law: MODEL1310110063#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:12069827 NOTES:

metaR r1615
product: MODEL1310110063#
modifier: MODEL1310110063#
is: SBO:0000185
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
kinetic law: MODEL1310110063#
type: Reaction
reversible: true
reactant: MODEL1310110063#
fast: false
notes: GENE_ASSOCIATION: (19.1) or (AL038231.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is described by: ECO:0000000

metaR r0331
modifier: MODEL1310110063#
notes: GENE_ASSOCIATION: (6576.1) SUBSYSTEM: Pyrimidine catabolism EC Number: 1.3.1.1 Confidence Level: 0 AUTHORS: PMID:1260500,PMID:8615641 NOTES:
is: SBO:0000176
product: MODEL1310110063#
reversible: false
is described by: ECO:0000000
type: Reaction
reactant: MODEL1310110063#
kinetic law: MODEL1310110063#
name: 5,6-Dihydrothymine:NAD+ oxidoreductase Pyrimidine metabolism EC:1.3.1.1
fast: false

http://identifiers.org/biomodels.db/MODEL1310110063#_909b5676_30d5_4eb5_9f4e_5afe282933a9
type: Species
is: SBO:0000252
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:518
boundary condition: true
name: ATP5G3
has only substance units: false
constant: false

http://identifiers.org/biomodels.db/MODEL1310110063#_2459fc66_a72f_42d1_88a2_008bc891772d
is encoded by: hsa:10965
name: ACOT2
is: P49753
boundary condition: true
is: SBO:0000252
constant: false
has only substance units: false
initial amount: NaN
initial concentration: NaN
type: Species

http://identifiers.org/biomodels.db/MODEL1310110063#_d9314329_8fd5_4c7e_9d58_aab9b790e2d1
constant: false
is: SBO:0000252
name: CA9
has only substance units: false
is: Q16790
boundary condition: true
initial amount: NaN
is encoded by: hsa:768
initial concentration: NaN
type: Species

metaR AG13T7g
modifier: MODEL1310110063#
name: N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase, Golgi apparatus
fast: false
type: Reaction
is: SBO:0000176
is described by: ECO:0000000
product: MODEL1310110063#
kinetic law: MODEL1310110063#
notes: GENE_ASSOCIATION: (79369.1) or (374907.1) or (11041.1) or (146712.1) or (374907.2) or (93010.1) or (10331.1) or (10678.1) or (10678.2) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.149 Confidence Level: 4 AUTHORS: PMID:10747980,PMID:11042166,PMID:12061784,PMID:12512857,PMID:15560372,PMID:15620693,PMID:9405606 NOTES:NCD
reactant: MODEL1310110063#
reversible: false
is version of: http://identifiers.org/ec-code/2.4.1.149

metaM lac L e
is: HMDB00190
boundary condition: false
is: SBO:0000247
initial amount: NaN
notes: FORMULA: C3H5O3 CHARGE: -1 INCHI: InChI=1S/C3H6O3/c1-2(4)3(5)6/h2,4H,1H3,(H,5,6)/p-1/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00177
name: (S)-lactate
initial concentration: 1.0
type: Species
is: CHEBI:16651
constant: false
has only substance units: false

metaM 5tedtricoa m
notes: FORMULA: C35H52N7O17P3S CHARGE: -4
boundary condition: false
has only substance units: false
is: HMDB02288
type: Species
is: SBO:0000247
constant: false
initial amount: NaN
initial concentration: 1.0
name: 5,8,11-tetradecatrienoylcoa

metaR C100CPT1
kinetic law: MODEL1310110063#
product: MODEL1310110063#
reactant: MODEL1310110063#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: production of decanoylcarnitine
type: Reaction

metaM octdececoa c
type: Species
initial concentration: 1.0
is: SBO:0000247
has only substance units: false
is: HMDB06351
initial amount: NaN
notes: FORMULA: C39H64N7O17P3S CHARGE: -4
boundary condition: false
name: octadecenoylcoa
constant: false

metaR C14OHc
kinetic law: MODEL1310110063#
product: MODEL1310110063#
reactant: MODEL1310110063#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: production of 3-hydroxytetradecanoylcarnitine
type: Reaction

metaR ADK3
product: MODEL1310110063#
kinetic law: MODEL1310110063#
type: Reaction
name: adentylate kinase (GTP)
notes: GENE_ASSOCIATION: (26289.1) or (26289.2) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: PMID:9434148 NOTES:JLR
reactant: MODEL1310110063#
is: SBO:0000176
fast: false
modifier: MODEL1310110063#
reversible: true
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/2.7.4.3

http://identifiers.org/biomodels.db/MODEL1310110063#_7af87bbe_f32b_45d4_8839_edb4eea02187
name: SDHC
has only substance units: false
initial concentration: NaN
is: Q99643
is: SBO:0000252
boundary condition: true
is encoded by: hsa:6391
initial amount: NaN
type: Species
constant: false

metaR GALASE14ly
is described by: ECO:0000000
kinetic law: MODEL1310110063#
reactant: MODEL1310110063#
fast: false
reversible: false
is version of: http://identifiers.org/ec-code/3.4.16.5
is version of: http://identifiers.org/ec-code/3.2.1.18
modifier: MODEL1310110063#
type: Reaction
product: MODEL1310110063#
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) or (5476.1) and (2720.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.23 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD
is: SBO:0000176
name: beta-galactosidase, lysosomal
is version of: http://identifiers.org/ec-code/3.2.1.23
is version of: http://identifiers.org/ec-code/3.1.6.4

metaM apoC Lys m
notes: FORMULA: C6H13N2OX CHARGE: 0
has only substance units: false
boundary condition: false
type: Species
constant: false
initial concentration: 1.0
initial amount: NaN
name: Apocarboxylase (Lys residue)
is: HMDB00182
is: CHEBI:32551
is: SBO:0000247

metaR GLYCTDle
type: Reaction
product: MODEL1310110063#
is: SBO:0000185
is described by: ECO:0000134
reactant: MODEL1310110063#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
reversible: true
name: difussion of glycerol accross the brush border membrane
kinetic law: MODEL1310110063#

http://identifiers.org/biomodels.db/MODEL1310110063#_03bb1916_88e9_429d_b647_a95dcc95e193
has only substance units: false
constant: false
is: SBO:0000252
is encoded by: hsa:N63787
initial amount: NaN
name: _N63787_1_c
type: Species
boundary condition: true
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110063#_a0e02dfc_eb50_4a54_a784_dbb14fe5346c
initial amount: NaN
has only substance units: false
boundary condition: true
name: CHKA
is encoded by: hsa:1119
type: Species
is: SBO:0000252
initial concentration: NaN
constant: false

metaR r1620
type: Reaction
is described by: ECO:0000000
is: SBO:0000185
reactant: MODEL1310110063#
product: MODEL1310110063#
reversible: true
kinetic law: MODEL1310110063#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
notes: GENE_ASSOCIATION: (19.1) or (AL038231.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
fast: false
modifier: MODEL1310110063#

metaM em2emgacpail prot hs r
boundary condition: false
is: CHEBI:16870
is: HMDB00086
has only substance units: false
name: (phosphoethanolaminyl-dimannosyl),(phosphoethanolaminyl)-mannosyl-glucosaminyl-acylphosphatidylinositol
constant: false
initial concentration: 1.0
is: SBO:0000247
initial amount: NaN
notes: FORMULA: C53H100N3O35P3FULLRCO2FULLR2CO2X CHARGE: 0
type: Species

metaR G14T5g
fast: false
name: beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase, Golgi
type: Reaction
notes: GENE_ASSOCIATION: (9334.1) or (2683.1) or (8704.2) or (8704.1) or (8703.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.38 Confidence Level: 4 AUTHORS: PMID:12512857,PMID:1903938,PMID:3094506,PMID:3144273,PMID:9405390,PMID:9435216 NOTES:Keratan sulfate II biosynthesis NCD
is version of: http://identifiers.org/ec-code/2.4.1.22
kinetic law: MODEL1310110063#
is version of: http://identifiers.org/ec-code/2.4.1.90
is described by: ECO:0000000
modifier: MODEL1310110063#
product: MODEL1310110063#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.4.1.38
reversible: false
reactant: MODEL1310110063#

metaR EX octa LPAREN e RPAREN
kinetic law: MODEL1310110063#
reactant: MODEL1310110063#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for octanoate (n-C8:0)
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110063#_7df939ac_739e_4a58_98fa_994bbe594362
has only substance units: false
is encoded by: hsa:4907
constant: false
initial concentration: NaN
is: SBO:0000252
name: NT5E
type: Species
boundary condition: true
is: P21589
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110063#_9e5b47a7_81f6_427d_b927_9ed97fa031a7
has only substance units: false
is encoded by: hsa:5295
type: Species
boundary condition: true
constant: false
name: PIK3R1
initial concentration: NaN
is: SBO:0000252
is: P27986
initial amount: NaN

metaR CMPSASn
is version of: http://identifiers.org/ec-code/2.7.7.43
product: MODEL1310110063#
is: SBO:0000176
reversible: false
kinetic law: MODEL1310110063#
notes: GENE_ASSOCIATION: (55907.1) SUBSYSTEM: Aminosugar metabolism EC Number: 2.7.7.43 Confidence Level: 2 AUTHORS: PMID:9689047 NOTES:NCD
type: Reaction
is described by: ECO:0000304
modifier: MODEL1310110063#
name: CMP sialic acid synthase, nuclear
fast: false
reactant: MODEL1310110063#

metaR DMNONCOACRNCPT1
product: MODEL1310110063#
type: Reaction
fast: false
name: DMNONCOACRNCPT1
kinetic law: MODEL1310110063#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 2 AUTHORS: PMID:9299016,PMID:9819701 NOTES:
reactant: MODEL1310110063#
is: SBO:0000176
reversible: true

metaR FRUt4
reactant: MODEL1310110063#
type: Reaction
modifier: MODEL1310110063#
name: D-fructose transport via sodium cotransport
is: SBO:0000185
kinetic law: MODEL1310110063#
notes: GENE_ASSOCIATION: (200010.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12748858,PMID:15607332 NOTES:NCD
fast: false
is described by: ECO:0000269
reversible: true
product: MODEL1310110063#

http://identifiers.org/biomodels.db/MODEL1310110063#_3b69213b_3c37_4ced_b8f4_8eb8faa01b66
name: CHST5
has only substance units: false
boundary condition: true
initial concentration: NaN
constant: false
is encoded by: hsa:23563
type: Species
initial amount: NaN
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110063#_b2b61575_adbb_413a_a52e_eb473e9cd7b5
boundary condition: true
name: _AI971036_1_x
initial amount: NaN
is encoded by: hsa:AI971036
initial concentration: NaN
has only substance units: false
type: Species
is: SBO:0000252
constant: false

metaM trp L e
notes: FORMULA: C11H12N2O2 CHARGE: 0 INCHI: InChI=1S/C11H12N2O2/c12-9(11(14)15)5-7-6-13-10-4-2-1-3-8(7)10/h1-4,6,9,13H,5,12H2,(H,14,15)/t9-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00080
is: SBO:0000247
boundary condition: false
initial concentration: 1.0
has only substance units: false
type: Species
initial amount: NaN
is: CHEBI:16828
constant: false
is: HMDB00929
name: L-tryptophan

http://identifiers.org/biomodels.db/MODEL1310110063#_69019615_bc4d_4d0f_a00e_3e023cd3fb6d
has only substance units: false
is: P23921
initial concentration: NaN
type: Species
boundary condition: true
initial amount: NaN
constant: false
is encoded by: hsa:6240
is: SBO:0000252
name: RRM1

http://identifiers.org/biomodels.db/MODEL1310110063#_ba00295f_8875_4772_93b1_a8110e89db88
name: TPK1
type: Species
constant: false
is: F5GZG6
boundary condition: true
initial amount: NaN
is encoded by: hsa:27010
has only substance units: false
is: SBO:0000252
initial concentration: NaN

metaM adrn e
is: CHEBI:53487
has only substance units: false
constant: false
notes: FORMULA: C22H35O2 CHARGE: -1 INCHI: InChI=1S/C22H36O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22(23)24/h6-7,9-10,12-13,15-16H,2-5,8,11,14,17-21H2,1H3,(H,23,24)/b7-6-,10-9-,13-12-,16-15-
is: HMDB02226
initial amount: NaN
name: adrenic acid
type: Species
initial concentration: 1.0
boundary condition: false
is: SBO:0000247

metaR PETOHMm hs
product: MODEL1310110063#
fast: false
notes: GENE_ASSOCIATION: (10400.2) or (10400.1) or (10400.3) SUBSYSTEM: Glycerophospholipid metabolism EC Number: 2.1.1.17 Confidence Level: 2 AUTHORS: PMID:9989271 NOTES:for human Catalyzes three sequential methylation of phosphatidylethanolamine (PE) by AdoMet, thus producing phosphatidylcholine (PC). [Swiss-prot] NJ
name: phosphatidylethanolamine N-methyltransferase
modifier: MODEL1310110063#
is: SBO:0000176
type: Reaction
reversible: false
is described by: ECO:0000254
kinetic law: MODEL1310110063#
reactant: MODEL1310110063#
is version of: http://identifiers.org/ec-code/2.1.1.17

metaR FAOXC15ATPx
kinetic law: MODEL1310110063#
product: MODEL1310110063#
reactant: MODEL1310110063#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid activation(C15)x
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110063#_c93fb24a_860f_4dea_81e8_7632cf098286
boundary condition: true
name: PIK3R1
type: Species
initial amount: NaN
constant: false
is: B3KT19
has only substance units: false
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:5295

metaR RBK
name: ribokinase
modifier: MODEL1310110063#
reversible: false
is: SBO:0000176
type: Reaction
notes: GENE_ASSOCIATION: (64080.1) SUBSYSTEM: Pentose phosphate pathway EC Number: Confidence Level: 2 AUTHORS: NOTES:
product: MODEL1310110063#
is version of: http://identifiers.org/ec-code/2.7.1.15
fast: false
is described by: ECO:0000304
kinetic law: MODEL1310110063#
reactant: MODEL1310110063#

metaM glx m
type: Species
is: HMDB00119
name: glyoxylate
constant: false
notes: FORMULA: C2H1O3 CHARGE: -1 INCHI: InChI=1S/C2H2O3/c3-1-2(4)5/h1H,(H,4,5)/p-1 EHMN_ABBREVIATION: C00048
is: SBO:0000247
has only substance units: false
initial concentration: 1.0
boundary condition: false
is: CHEBI:36655
initial amount: NaN

metaM dd2coa m
type: Species
has only substance units: false
constant: false
boundary condition: false
is: CHEBI:57330
notes: FORMULA: C33H52N7O17P3S CHARGE: -4 INCHI: InChI=1S/C33H56N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-24(42)61-17-16-35-23(41)14-15-36-31(45)28(44)33(2,3)19-54-60(51,52)57-59(49,50)53-18-22-27(56-58(46,47)48)26(43)32(55-22)40-21-39-25-29(34)37-20-38-30(25)40/h12-13,20-22,26-28,32,43-44H,4-11,14-19H2,1-3H3,(H,35,41)(H,36,45)(H,49,50)(H,51,52)(H2,34,37,38)(H2,46,47,48)/p-4/b13-12+/t22-,26-,27-,28+,32-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01078 EHMN_ABBREVIATION: C03221
initial amount: NaN
initial concentration: 1.0
is: HMDB03712
name: trans-dodec-2-enoyl-CoA(4-)
is: SBO:0000247

metaM akg e
boundary condition: false
constant: false
type: Species
has only substance units: false
initial amount: NaN
is: CHEBI:16810
initial concentration: 1.0
is: HMDB00208
name: 2-oxoglutarate(2-)
notes: FORMULA: C5H4O5 CHARGE: -2 INCHI: InChI=1S/C5H6O5/c6-3(5(9)10)1-2-4(7)8/h1-2H2,(H,7,8)(H,9,10)/p-2 HEPATONET_1.0_ABBREVIATION: HC00035 EHMN_ABBREVIATION: C00026
is: SBO:0000247

metaR OCT11EFATP
kinetic law: MODEL1310110063#
product: MODEL1310110063#
reactant: MODEL1310110063#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: uptake of vaccenic acid by cells
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110063#_9ca7338c_67da_4600_ad90_cf9b999ff3c3
has part: P23378
is encoded by: hsa:2731
is: SBO:0000297
initial amount: NaN
is encoded by: hsa:275
boundary condition: true
has only substance units: false
is encoded by: hsa:2653
name: DLD:GCSH:GLDC:AMT
type: Species
initial concentration: NaN
has part: P48728
constant: false
has part: P23434

http://identifiers.org/biomodels.db/MODEL1310110063#_6c315893_e6f0_416c_972d_61c790e1312b
name: ACSL4
initial concentration: NaN
type: Species
boundary condition: true
has only substance units: false
is: O60488
is encoded by: hsa:2182
initial amount: NaN
is: SBO:0000252
constant: false

metaR MI13PP
notes: GENE_ASSOCIATION: SUBSYSTEM: Inositol phosphate metabolism EC Number: 3.1.3.64 Confidence Level: 2 AUTHORS: PMID:2906139 NOTES:NCD
is described by: ECO:0000000
fast: false
name: inositol-1,3-bisphosphate 3-phosphatase
reversible: false
is: SBO:0000176
reactant: MODEL1310110063#
kinetic law: MODEL1310110063#
type: Reaction
product: MODEL1310110063#

metaR r2338
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12883891 NOTES:
reactant: MODEL1310110063#
type: Reaction
is described by: ECO:0000000
reversible: true
product: MODEL1310110063#
is: SBO:0000185
kinetic law: MODEL1310110063#
fast: false
name: Major Facilitator(MFS) TCDB:2.A.1.19.1

metaR r2443
kinetic law: MODEL1310110063#
name: Proposed Fatty Acid Transporter (FAT) TCDB:4.C.1.1.5
is: SBO:0000185
is described by: ECO:0000000
reactant: MODEL1310110063#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
reversible: false
fast: false
product: MODEL1310110063#
type: Reaction

metaM gln L e
boundary condition: false
initial amount: NaN
is: HMDB00641
constant: false
is: CHEBI:18050
has only substance units: false
notes: FORMULA: C5H10N2O3 CHARGE: 0 INCHI: InChI=1S/C5H10N2O3/c6-3(5(9)10)1-2-4(7)8/h3H,1-2,6H2,(H2,7,8)(H,9,10)/t3-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00067
initial concentration: 1.0
name: L-glutamine
is: SBO:0000247
type: Species

metaR r0541
reactant: MODEL1310110063#
reversible: true
modifier: MODEL1310110063#
kinetic law: MODEL1310110063#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.6.1.5
type: Reaction
product: MODEL1310110063#
name: Glutaryl-CoA:(acceptor) 2,3-oxidoreductase (decarboxylating) Fatty acid metabolism EC:1.3.99.7
notes: GENE_ASSOCIATION: (AV717590.1) or (953.1) or (956.1) or (377841.1) SUBSYSTEM: Tryptophan metabolism EC Number: 1.3.99.7 Confidence Level: 0 AUTHORS: PMID:3081514 NOTES:
fast: false
is described by: ECO:0000000

metaR VALt5m
kinetic law: MODEL1310110063#
type: Reaction
reactant: MODEL1310110063#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:11004451 NOTES:MM
reversible: true
is described by: ECO:0000000
fast: false
product: MODEL1310110063#
is: SBO:0000185
name: Valine reversible mitochondrial transport

metaM 4hpro LT m
has only substance units: false
initial concentration: 1.0
initial amount: NaN
notes: FORMULA: C5H9NO3 CHARGE: 0 INCHI: InChI=1S/C5H9NO3/c7-3-1-4(5(8)9)6-2-3/h3-4,6-7H,1-2H2,(H,8,9)/t3-,4+/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00690
is: HMDB00725
boundary condition: false
is: SBO:0000247
constant: false
is: CHEBI:18095
type: Species
name: trans-4-hydroxy-L-proline

http://identifiers.org/biomodels.db/MODEL1310110063#_4c13dde5_46ed_487a_8c17_61739f9ec886
constant: false
initial concentration: NaN
is: SBO:0000252
initial amount: NaN
type: Species
boundary condition: true
name: PDE8A
is encoded by: hsa:5151
has only substance units: false

metaR SQLSr
is: SBO:0000176
kinetic law: MODEL1310110063#
notes: GENE_ASSOCIATION: (2222.1) SUBSYSTEM: Cholesterol metabolism EC Number: 2.5.1.21 Confidence Level: 4 AUTHORS: PMID:1318747 NOTES:This is a lumped reaction: Rxn 1: 2 frdp -> 2 ppi + presqualene diphosphate Rxn 2: presqualene diphosphate + NADPH -> squalene + NADP NCD ER version - NJ
reactant: MODEL1310110063#
is described by: ECO:0000134
reversible: false
type: Reaction
fast: false
modifier: MODEL1310110063#
is version of: http://identifiers.org/ec-code/2.5.1.21
name: Squalene synthase
product: MODEL1310110063#

http://identifiers.org/biomodels.db/MODEL1310110063#_ffcf1911_9a11_4bcd_90bf_5b957e63c649
initial concentration: NaN
initial amount: NaN
name: _X63359_1_c
type: Species
is encoded by: hsa:X63359
boundary condition: true
constant: false
has only substance units: false
is: SBO:0000252

metaM trp L c
boundary condition: false
initial concentration: 1.0
notes: FORMULA: C11H12N2O2 CHARGE: 0 INCHI: InChI=1S/C11H12N2O2/c12-9(11(14)15)5-7-6-13-10-4-2-1-3-8(7)10/h1-4,6,9,13H,5,12H2,(H,14,15)/t9-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00080
constant: false
is: SBO:0000247
has only substance units: false
name: L-tryptophan
is: CHEBI:16828
initial amount: NaN
type: Species
is: HMDB00929

metaR RE3626M
is: SBO:0000176
kinetic law: MODEL1310110063#
is version of: http://identifiers.org/ec-code/1.3.3.6
fast: false
is described by: ECO:0000000
reactant: MODEL1310110063#
name: RE3626
type: Reaction
product: MODEL1310110063#
reversible: false
notes: GENE_ASSOCIATION: (51.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.3.6 Confidence Level: 0 AUTHORS: PMID:11356164,PMID:7775433 NOTES:
modifier: MODEL1310110063#

http://identifiers.org/biomodels.db/MODEL1310110063#_80f8dd9f_f0cd_4b35_8644_7774cd98eb7b
initial amount: NaN
is encoded by: hsa:498
is: SBO:0000252
initial concentration: NaN
has only substance units: false
type: Species
name: ATP5A1
is: P25705
constant: false
boundary condition: true

metaM HC00900 c
constant: false
initial amount: NaN
boundary condition: false
type: Species
initial concentration: 1.0
is: CHEBI:30860
name: Methylmalonate
is: SBO:0000247
notes: FORMULA: C4H4O4 CHARGE: -2 INCHI: InChI=1S/C4H6O4/c1-2(3(5)6)4(7)8/h2H,1H3,(H,5,6)(H,7,8) EHMN_ABBREVIATION: C02170
has only substance units: false

metaR r0027
product: MODEL1310110063#
type: Reaction
kinetic law: MODEL1310110063#
notes: GENE_ASSOCIATION: (285973.1) or (D29675.1) or (4842.1) or (NOS2A.1) or (4846.1) SUBSYSTEM: Methionine and cysteine metabolism EC Number: 1.8.1.9 Confidence Level: 0 AUTHORS: PMID:18042542 NOTES:
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/1.14.13.39
fast: false
name: NADPH:CoA-glutathione oxidoreductase EC:1.8.1.9
is: SBO:0000176
reactant: MODEL1310110063#
modifier: MODEL1310110063#
reversible: true

metaR RTOTAL2FATPc
kinetic law: MODEL1310110063#
product: MODEL1310110063#
reactant: MODEL1310110063#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: uptake of Rtotal2 by enterocytes
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110063#_f3316ef2_a172_4839_ac82_d08d6dc01884
name: SLC22A2
type: Species
is: O15244
is encoded by: hsa:6582
constant: false
initial amount: NaN
is: SBO:0000252
has only substance units: false
initial concentration: NaN
boundary condition: true

metaR TAUBETAtc
kinetic law: MODEL1310110063#
product: MODEL1310110063#
reactant: MODEL1310110063#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of taurine into the intestinal cells by beta transport system
type: Reaction

metaM akg c
is: C00026
initial concentration: 1.0
initial amount: NaN
boundary condition: false
is: CHEBI:16810
has only substance units: false
is: SBO:0000247
is: HMDB00208
type: Species
notes: FORMULA: C5H4O5 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00035 EHMN_ABBREVIATION: C00026
name: 2-Oxoglutarate
constant: false

metaM doco13ecoa c
boundary condition: false
initial concentration: 1.0
has only substance units: false
notes: FORMULA: C43H72N7O17P3S CHARGE: -4
constant: false
name: 13-docosenoylcoa
is: SBO:0000247
type: Species
initial amount: NaN
is: http://identifiers.org/pubchem.compound/24892791

metaR PItx
reversible: true
is: SBO:0000185
reactant: MODEL1310110063#
fast: false
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 1 AUTHORS: NOTES:diffusion NJ
product: MODEL1310110063#
kinetic law: MODEL1310110063#
name: Phosphate transporter, peroxisome
type: Reaction

metaM dcsptn1 c
notes: FORMULA: C22H33O2 CHARGE: -1 INCHI: InChI=1/C22H34O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22(23)24/h6-7,9-10,12-13,15-16,18-19H,2-5,8,11,14,17,20-21H2,1H3,(H,23,24)/b7-6-,10-9-,13-12-,16-15-,19-18-
initial amount: NaN
has only substance units: false
is: HMDB13123
type: Species
constant: false
is: SBO:0000247
initial concentration: 1.0
name: docosa-4,7,10,13,16-pentaenoic acid
boundary condition: false
is: http://identifiers.org/pubchem.compound/5282848

metaR HAS1
reversible: false
type: Reaction
fast: false
notes: GENE_ASSOCIATION: (3038.2) or (3036.1) or (3038.1) or (3037.1) SUBSYSTEM: Hyaluronan metabolism EC Number: 2.4.1.212 Confidence Level: 4 AUTHORS: PMID:12512858,PMID:8651928,PMID:8798477,PMID:8798544,PMID:9083017 NOTES:NCD
reactant: MODEL1310110063#
name: hyaluronan synthase
kinetic law: MODEL1310110063#
is version of: http://identifiers.org/ec-code/2.4.1.212
is: SBO:0000185
is described by: ECO:0000269
product: MODEL1310110063#
modifier: MODEL1310110063#

metaR EX 34dhoxpeg LPAREN e RPAREN
kinetic law: MODEL1310110063#
reactant: MODEL1310110063#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 3,4-Dihydroxyphenylethyleneglycol exchange
type: Reaction

metaR H2Oter
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD
reversible: true
kinetic law: MODEL1310110063#
reactant: MODEL1310110063#
is: SBO:0000185
name: H2O endoplasmic reticulum transport
product: MODEL1310110063#
fast: false
type: Reaction
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110063#_0e57ce69_7bcf_4e98_800d_893473a77b32
has only substance units: false
type: Species
initial concentration: NaN
is encoded by: hsa:5152
is: SBO:0000252
name: PDE9A
boundary condition: true
initial amount: NaN
constant: false

metaR GLYCtm
is: SBO:0000185
kinetic law: MODEL1310110063#
name: glycerol transport
type: Reaction
product: MODEL1310110063#
reversible: true
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: NOTES:TDV
reactant: MODEL1310110063#
fast: false

http://identifiers.org/biomodels.db/MODEL1310110063#_a3f7247d_535f_4e5c_a064_cdbb0a627c84
is encoded by: hsa:5167
constant: false
is: P22413
is: SBO:0000252
has only substance units: false
boundary condition: true
initial concentration: NaN
initial amount: NaN
type: Species
name: ENPP1

metaR FATP2t
reactant: MODEL1310110063#
product: MODEL1310110063#
notes: GENE_ASSOCIATION: (376497.1) or (376497.2) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12856180,PMID:15522816 NOTES:electroneutral transport NJ
modifier: MODEL1310110063#
type: Reaction
fast: false
is: SBO:0000185
is described by: ECO:0000269
reversible: true
kinetic law: MODEL1310110063#
name: fatty acid electroneutral transport

metaR ADK1
is described by: ECO:0000269
type: Reaction
kinetic law: MODEL1310110063#
reactant: MODEL1310110063#
is: SBO:0000176
fast: false
reversible: true
modifier: MODEL1310110063#
is version of: http://identifiers.org/ec-code/2.7.4.3
notes: GENE_ASSOCIATION: (122481.1) or (203.1) or (26289.1) or (26289.2) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: NOTES:
name: adenylate kinase
product: MODEL1310110063#

metaM gln L c
has only substance units: false
is: HMDB00641
constant: false
initial amount: NaN
boundary condition: false
type: Species
is: SBO:0000247
notes: FORMULA: C5H10N2O3 CHARGE: 0 INCHI: InChI=1S/C5H10N2O3/c6-3(5(9)10)1-2-4(7)8/h3H,1-2,6H2,(H2,7,8)(H,9,10)/t3-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00067
name: L-glutamine
initial concentration: 1.0
is: CHEBI:18050

metaR GARFT
is: SBO:0000176
reactant: MODEL1310110063#
reversible: true
name: phosphoribosylglycinamide formyltransferase
is described by: ECO:0000269
fast: false
modifier: MODEL1310110063#
product: MODEL1310110063#
is version of: http://identifiers.org/ec-code/2.1.2.2
notes: GENE_ASSOCIATION: (2618.1) or (2618.2) SUBSYSTEM: Purine synthesis EC Number: 2.1.2.2 Confidence Level: 4 AUTHORS: PMID:12450384,PMID:2183217,PMID:9328467,PMID:9473452 NOTES:
kinetic law: MODEL1310110063#
type: Reaction

metaM sprm e
notes: FORMULA: C10H30N4 CHARGE: 4 INCHI: InChI=1S/C10H26N4/c11-5-3-9-13-7-1-2-8-14-10-4-6-12/h13-14H,1-12H2 HEPATONET_1.0_ABBREVIATION: HC00525 EHMN_ABBREVIATION: C00750
initial concentration: 1.0
name: spermine(4+)
is: HMDB01256
boundary condition: false
is: SBO:0000247
has only substance units: false
type: Species
initial amount: NaN
is: CHEBI:45725
constant: false

metaR RE1533M
is version of: http://identifiers.org/ec-code/4.2.1.17
notes: GENE_ASSOCIATION: (10449.1) or (3032.1) or (3030.1) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.16 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:7923814,PMID:9568246,PMID:9920399 NOTES:
reversible: true
fast: false
name: RE1533
is: SBO:0000176
type: Reaction
reactant: MODEL1310110063#
modifier: MODEL1310110063#
kinetic law: MODEL1310110063#
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/2.3.1.16
product: MODEL1310110063#

http://identifiers.org/biomodels.db/MODEL1310110063#_8e7c76a9_16b8_47ba_9399_deb6122b8d60
initial concentration: NaN
name: ATP5A1
type: Species
is encoded by: hsa:498
initial amount: NaN
has only substance units: false
is: B4DY56
is: SBO:0000252
boundary condition: true
constant: false

http://identifiers.org/biomodels.db/MODEL1310110063#_f5651cc6_465f_471e_a22b_2894bb02d482
constant: false
has only substance units: false
type: Species
name: ELOVL5
is encoded by: hsa:60481
is: F6SH78
boundary condition: true
is: SBO:0000252
initial amount: NaN
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110063#_69773cfd_7964_4893_a1db_20bddc41aa6c
is: SBO:0000252
has only substance units: false
name: SLC27A2
boundary condition: true
is encoded by: hsa:11001
initial amount: NaN
constant: false
is: O14975
initial concentration: NaN
type: Species

metaM accoa x
constant: false
is: SBO:0000247
has only substance units: false
boundary condition: false
initial amount: NaN
is: HMDB01206
is: CHEBI:57288
initial concentration: 1.0
type: Species
name: Acetyl-CoA
is: C00024
notes: FORMULA: C23H34N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00033 EHMN_ABBREVIATION: C00024

metaR EX pydx LPAREN e RPAREN
kinetic law: MODEL1310110063#
reactant: MODEL1310110063#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for Pyridoxal
type: Reaction

metaR PGDI
reactant: MODEL1310110063#
fast: false
is: SBO:0000176
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/5.3.99.2
notes: GENE_ASSOCIATION: (5730.1) or (27306.1) SUBSYSTEM: Eicosanoid metabolism EC Number: 5.3.99.2 Confidence Level: 4 AUTHORS: PMID:9065498,PMID:9353279 NOTES:noted on RER, but also cytoplasmic structures NJ
name: Prostaglandin-H2 D-isomerase [Precursor]
product: MODEL1310110063#
modifier: MODEL1310110063#
type: Reaction
is version of: http://identifiers.org/ec-code/2.5.1.18
kinetic law: MODEL1310110063#
reversible: true

metaR S6TASE16ly
is: SBO:0000176
reversible: true
name: N-acetylglucosamine-6-sulfatase, lysosomal
notes: GENE_ASSOCIATION: (2799.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.1.6.14 Confidence Level: 4 AUTHORS: PMID:3196333,PMID:3689314,PMID:3689315 NOTES:NCD
kinetic law: MODEL1310110063#
modifier: MODEL1310110063#
reactant: MODEL1310110063#
product: MODEL1310110063#
is described by: ECO:0000000
type: Reaction
fast: false
is version of: http://identifiers.org/ec-code/3.1.6.14

metaR NACHEX24ly
reactant: MODEL1310110063#
kinetic law: MODEL1310110063#
reversible: false
is described by: ECO:0000000
type: Reaction
is: SBO:0000176
fast: false
is version of: http://identifiers.org/ec-code/3.2.1.52
product: MODEL1310110063#
notes: GENE_ASSOCIATION: (3074.1) or (3073.1) or (3073.1 and 3074.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.52 Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12706724,PMID:8993162 NOTES:NCD
name: beta-N-acetylhexosaminidase, lysosomal
modifier: MODEL1310110063#

metaM imp c
is: SBO:0000247
is: C00130
initial amount: NaN
type: Species
initial concentration: 1.0
is: HMDB00175
has only substance units: false
notes: FORMULA: C10H11N4O8P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00128 EHMN_ABBREVIATION: C00130
boundary condition: false
constant: false
is: CHEBI:58053
name: IMP

http://identifiers.org/biomodels.db/MODEL1310110063#_2de8e099_5836_4fc9_b655_7750189e8fcc
constant: false
type: Species
initial concentration: NaN
is encoded by: hsa:1384
is: P43155
boundary condition: true
is: SBO:0000252
has only substance units: false
name: CRAT
initial amount: NaN

metaR C4STMO2r
reversible: false
is described by: ECO:0000000
kinetic law: MODEL1310110063#
is version of: http://identifiers.org/ec-code/1.1.1.170
type: Reaction
notes: GENE_ASSOCIATION: (6307.1) or (50814.1) SUBSYSTEM: Cholesterol metabolism EC Number: Confidence Level: 4 AUTHORS: NOTES:double check rxn specifics - see lit ref: Marijanovic, Molecular Endocrinology 2003 17:1715-1725 ER version NJ
name: C-4 methyl sterol oxidase
modifier: MODEL1310110063#
fast: false
product: MODEL1310110063#
is: SBO:0000176
reactant: MODEL1310110063#
is version of: http://identifiers.org/ec-code/1.14.13.72

metaR BILDGLCURtr
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: NOTES:unknown mechanism, however glucuronidated metabolites need to get out of the cell NJ
type: Reaction
reactant: MODEL1310110063#
kinetic law: MODEL1310110063#
name: glucuronidated compound transport
fast: false
is: SBO:0000185
reversible: true
is described by: ECO:0000000
product: MODEL1310110063#

http://identifiers.org/biomodels.db/MODEL1310110063#_9840acfc_d692_41ce_93be_429b7f3b0ed2
name: PIK3C2B
initial concentration: NaN
constant: false
initial amount: NaN
is: O00750
type: Species
boundary condition: true
has only substance units: false
is encoded by: hsa:5287
is: SBO:0000252

metaM c226coa x
type: Species
name: cervonyl coenzyme A
initial amount: NaN
notes: FORMULA: C43H62N7O17P3S CHARGE: -4 INCHI: InChI=1/C43H66N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-34(52)71-27-26-45-33(51)24-25-46-41(55)38(54)43(2,3)29-64-70(61,62)67-69(59,60)63-28-32-37(66-68(56,57)58)36(53)42(65-32)50-31-49-35-39(44)47-30-48-40(35)50/h5-6,8-9,11-12,14-15,17-18,20-21,30-32,36-38,42,53-54H,4,7,10,13,16,19,22-29H2,1-3H3,(H,45,51)(H,46,55)(H,59,60)(H,61,62)(H2,44,47,48)(H2,56,57,58)/b6-5-,9-8-,12-11-,15-14-,18-17-,21-20-/t32-,36-,37-,38?,42-/m1/s1
is: http://identifiers.org/pubchem.compound/47205479
is: SBO:0000247
has only substance units: false
constant: false
boundary condition: false
is: C16169
initial concentration: 1.0

metaM cyan e
boundary condition: false
initial amount: NaN
is: SBO:0000247
initial concentration: 1.0
type: Species
name: hydrogen cyanide
is: HMDB02084
notes: FORMULA: CHN CHARGE: 0 INCHI: InChI=1S/CHN/c1-2/h1H EHMN_ABBREVIATION: C01326
is: CHEBI:18407
has only substance units: false
constant: false

metaR FAOXC81C61x
kinetic law: MODEL1310110063#
product: MODEL1310110063#
reactant: MODEL1310110063#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C8:1-->C6:1)x
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110063#_36a5d371_bd76_4926_8280_1484d1bab4aa
has part: P48736
has only substance units: false
is encoded by: hsa:10870
initial concentration: NaN
has part: Q9UBK5
name: HCST:PIK3CG
is encoded by: hsa:5294
type: Species
boundary condition: true
constant: false
is: SBO:0000297
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110063#_ad896d7c_2aab_4494_b531_d0ce43496a06
constant: false
initial concentration: NaN
name: ALDH1B1
type: Species
is: P30837
has only substance units: false
is encoded by: hsa:219
is: SBO:0000252
boundary condition: true
initial amount: NaN

metaM ksii core4 e
constant: false
initial amount: NaN
is: SBO:0000247
has only substance units: false
initial concentration: 1.0
is: HMDB00211
type: Species
notes: FORMULA: C89H142N7O72S3X CHARGE: -4
is: CHEBI:17268
boundary condition: false
name: keratan sulfate II (core 4-linked)

metaR r2334
product: MODEL1310110063#
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
reactant: MODEL1310110063#
kinetic law: MODEL1310110063#
type: Reaction
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
fast: false
is described by: ECO:0000000
reversible: true

metaM dcsptn1 e
notes: FORMULA: C22H33O2 CHARGE: -1 INCHI: InChI=1/C22H34O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22(23)24/h6-7,9-10,12-13,15-16,18-19H,2-5,8,11,14,17,20-21H2,1H3,(H,23,24)/b7-6-,10-9-,13-12-,16-15-,19-18-
name: docosa-4,7,10,13,16-pentaenoic acid
is: SBO:0000247
has only substance units: false
initial amount: NaN
is: http://identifiers.org/pubchem.compound/5282848
boundary condition: false
type: Species
is: HMDB13123
constant: false
initial concentration: 1.0

metaR PAIL HStn
fast: false
product: MODEL1310110063#
is described by: ECO:0000000
name: phosphatidylinositol nuclear transport (diffusion)
is: SBO:0000185
reactant: MODEL1310110063#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 1 AUTHORS: NOTES:
reversible: true
kinetic law: MODEL1310110063#

http://identifiers.org/biomodels.db/MODEL1310110063#_3f3b700d_ff86_48df_a7a1_c22e8cfc3443
type: Species
constant: false
is: SBO:0000252
initial concentration: NaN
has only substance units: false
is: Q9NPH0
boundary condition: true
name: ACP6
is encoded by: hsa:51205
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110063#_6d10f983_c1a5_48cd_80ac_8e9c9e361301
initial amount: NaN
is: SBO:0000252
boundary condition: true
initial concentration: NaN
is: P56556
type: Species
name: NDUFA6
constant: false
is encoded by: hsa:4700
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110063#_9f617428_e41f_4bc0_8f2c_0e7466ed2567
initial concentration: NaN
is encoded by: hsa:5332
constant: false
type: Species
is: Q15147
is: SBO:0000252
initial amount: NaN
boundary condition: true
name: PLCB4
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110063#_8650a19c_c06c_49a5_8383_37e63e8207a9
boundary condition: true
constant: false
has only substance units: false
initial concentration: NaN
is encoded by: hsa:AI971036
name: _AI971036_1_m
is: SBO:0000252
initial amount: NaN
type: Species

metaM g1p c
initial concentration: 1.0
is: HMDB01586
is: C00103
has only substance units: false
is: CHEBI:58601
is: SBO:0000247
type: Species
constant: false
name: D-Glucose 1-phosphate
notes: FORMULA: C6H11O9P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00103 EHMN_ABBREVIATION: C00103
boundary condition: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110063#_e19dd083_a1b6_4311_9fbe_6bfaff541120
name: ALG3
has only substance units: false
is: Q92685
constant: false
boundary condition: true
initial amount: NaN
type: Species
is encoded by: hsa:10195
is: SBO:0000252
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110063#_b081738a_dc0d_4ca5_847f_6d06ba6ba686
initial amount: NaN
boundary condition: true
constant: false
has part: Q9UN42
has only substance units: false
has part: P50993
name: ATP1B4:ATP1A2
initial concentration: NaN
is encoded by: hsa:477
is encoded by: hsa:23439
type: Species
is: SBO:0000297

metaM 4mzym int1 r
initial concentration: 1.0
name: 4-Methylzymosterol intermediate 1
is: HMDB06927
type: Species
has only substance units: false
constant: false
initial amount: NaN
notes: FORMULA: C29H46O3 CHARGE: 0 INCHI: InChI=1/C29H46O3/c1-18(2)8-7-9-19(3)21-11-12-22-20-10-13-24-28(5,23(20)14-16-27(21,22)4)17-15-25(30)29(24,6)26(31)32/h8,19,21-22,24-25,30H,7,9-17H2,1-6H3,(H,31,32)/t19-,21?,22?,24?,25-,27+,28+,29-/m0/s1
is: SBO:0000247
boundary condition: false

metaM rib D c
initial amount: NaN
has only substance units: false
constant: false
is: CHEBI:16988
notes: FORMULA: C5H10O5 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00119
is: SBO:0000247
name: D-ribose
boundary condition: false
initial concentration: 1.0
type: Species
is: HMDB00283

metaM imp e
is: CHEBI:58053
notes: FORMULA: C10H11N4O8P CHARGE: -2 INCHI: InChI=1S/C10H13N4O8P/c15-6-4(1-21-23(18,19)20)22-10(7(6)16)14-3-13-5-8(14)11-2-12-9(5)17/h2-4,6-7,10,15-16H,1H2,(H,11,12,17)(H2,18,19,20)/p-2/t4-,6-,7-,10-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00128 EHMN_ABBREVIATION: C00130
is: HMDB00175
type: Species
boundary condition: false
initial amount: NaN
has only substance units: false
initial concentration: 1.0
is: SBO:0000247
name: IMP(2-)
constant: false

metaR r2335
type: Reaction
is described by: ECO:0000000
product: MODEL1310110063#
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
reversible: true
reactant: MODEL1310110063#
kinetic law: MODEL1310110063#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
fast: false

http://identifiers.org/biomodels.db/MODEL1310110063#_07891634_cf91_4f7f_8734_7c1cf563976f
boundary condition: true
is encoded by: hsa:H17063
has only substance units: false
initial concentration: NaN
constant: false
type: Species
is: SBO:0000252
name: _H17063_1_m
initial amount: NaN

metaM apoC Lys btn m
initial concentration: 1.0
has only substance units: false
initial amount: NaN
boundary condition: false
is: C05552
name: Holocarboxylase (biotin covalent bound to Lys residue of apoC)
notes: FORMULA: C16H27N4O3SX CHARGE: 0
is: SBO:0000247
is: http://identifiers.org/pubchem.compound/7886
constant: false
is: HMDB03134
type: Species

metaM octdececoa m
has only substance units: false
is: SBO:0000247
constant: false
initial amount: NaN
type: Species
notes: FORMULA: C39H64N7O17P3S CHARGE: -4
initial concentration: 1.0
boundary condition: false
name: octadecenoylcoa
is: http://identifiers.org/pubchem.compound/5280355

http://identifiers.org/biomodels.db/MODEL1310110063#_76a16abe_74f5_4d14_9c33_48f880f7dabd
type: Species
is: Q7KYS4
is: SBO:0000252
boundary condition: true
is encoded by: hsa:5143
name: PDE4C
initial amount: NaN
constant: false
has only substance units: false
initial concentration: NaN

metaR S6T11g
notes: GENE_ASSOCIATION: (23563.2) or (9435.1) or (23563.1) or (10164.1) or (4166.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: Confidence Level: 4 AUTHORS: PMID:10330415,PMID:10491328,PMID:10913333,PMID:11278593,PMID:12403612,PMID:12855678,PMID:9722682 NOTES:NCD
reversible: false
kinetic law: MODEL1310110063#
name: galactose/N-acetylglucosamine 6-O-sulfotransferase, Golgi apparatus
fast: false
is: SBO:0000176
product: MODEL1310110063#
modifier: MODEL1310110063#
type: Reaction
reactant: MODEL1310110063#
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110063#_6ce412b1_7309_4032_a263_b6ecb2657fb9
has only substance units: false
initial amount: NaN
is: Q14435
is encoded by: hsa:2591
name: GALNT3
is: SBO:0000252
initial concentration: NaN
boundary condition: true
constant: false
type: Species

metaR XOLDIOLONEt
reversible: true
kinetic law: MODEL1310110063#
name: lipid, flip-flop intracellular transport
type: Reaction
fast: false
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: PMID:12840657 NOTES:cholesterol precursor, transport by "diffusion" -> actually beleived to be flip-flop mechanism (PMID: 12840657). NJ
product: MODEL1310110063#
reactant: MODEL1310110063#
is: SBO:0000185

metaR CYSGLYexR
type: Reaction
name: L-cysteine/glycine reversible exchanger
fast: false
product: MODEL1310110063#
reactant: MODEL1310110063#
is described by: ECO:0000000
kinetic law: MODEL1310110063#
is: SBO:0000185
reversible: true
modifier: MODEL1310110063#
notes: GENE_ASSOCIATION: (6520.1) and (23428.1) or (6520.1) and (23428.2) or (56301.1) and (6520.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10734121,PMID:10863037,PMID:14770310 NOTES:Merged CYSGLYexR and CYSGLYex - (May 2011) IT

metaR FACOAL191
kinetic law: MODEL1310110063#
name: fatty-acid--CoA ligase
modifier: MODEL1310110063#
product: MODEL1310110063#
is described by: ECO:0000269
is: SBO:0000176
notes: GENE_ASSOCIATION: (11001.1) SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 4 AUTHORS: PMID:11591435 NOTES:current models suggest COAL activity occurs on outer peroxisomal membrane NJ
is version of: http://identifiers.org/ec-code/6.2.1.3
reversible: false
type: Reaction
reactant: MODEL1310110063#
fast: false

metaM hs deg13 l
name: heparan sulfate, degradation product 13
initial concentration: 1.0
is: CHEBI:17180
constant: false
type: Species
notes: FORMULA: C55H83N3O61S5 CHARGE: -6
initial amount: NaN
is: SBO:0000247
has only substance units: false
is: HMDB01352
boundary condition: false

metaR MERCPLACCYSt
kinetic law: MODEL1310110063#
reactant: MODEL1310110063#
type: Reaction
is: SBO:0000185
name: 3-mercaptolactate-cysteine disulfide transport, extracellular
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:excretion of 3-mercaptolactate-cysteine disulfide (PMID: 6945862) MM
is described by: ECO:0000000
reversible: false
product: MODEL1310110063#
fast: false

metaM CE5120 m
initial concentration: 1.0
boundary condition: false
initial amount: NaN
type: Species
notes: FORMULA: C35H54N7O17P3S CHARGE: -4 INCHI: InChI=1/C35H58N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-26(44)63-19-18-37-25(43)16-17-38-33(47)30(46)35(2,3)21-56-62(53,54)59-61(51,52)55-20-24-29(58-60(48,49)50)28(45)34(57-24)42-23-41-27-31(36)39-22-40-32(27)42/h8-9,14-15,22-24,28-30,34,45-46H,4-7,10-13,16-21H2,1-3H3,(H,37,43)(H,38,47)(H,51,52)(H,53,54)(H2,36,39,40)(H2,48,49,50)/p-4/b9-8-,15-14+/t24-,28+,29+,30u,34-/m0/s1 EHMN_ABBREVIATION: CE5120
has only substance units: false
constant: false
is: CHEBI:57923
is: SBO:0000247
name: trans-2-cis-8-tetradecadienoyl-CoA

metaM gum e
boundary condition: false
is: SBO:0000247
has only substance units: false
name: gums
initial amount: NaN
is: http://identifiers.org/pubchem.compound/93131
constant: false
initial concentration: 1.0
notes: FORMULA: C2760000H5060000O2530000 CHARGE: 0
type: Species

metaM gmp g
boundary condition: false
type: Species
initial concentration: 1.0
initial amount: NaN
is: HMDB01397
constant: false
name: GMP(3-)
is: SBO:0000247
is: CHEBI:58115
has only substance units: false
notes: FORMULA: C10H12N5O8P CHARGE: -2 INCHI: InChI=1S/C10H14N5O8P/c11-10-13-7-4(8(18)14-10)12-2-15(7)9-6(17)5(16)3(23-9)1-22-24(19,20)21/h2-3,5-6,9,16-17H,1H2,(H2,19,20,21)(H3,11,13,14,18)/p-2/t3-,5-,6-,9-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00141 EHMN_ABBREVIATION: C00144

metaR RE1522M
type: Reaction
is version of: http://identifiers.org/ec-code/1.1.1.35
modifier: MODEL1310110063#
is described by: ECO:0000000
reactant: MODEL1310110063#
kinetic law: MODEL1310110063#
reversible: true
product: MODEL1310110063#
is version of: http://identifiers.org/ec-code/4.2.1.17
is version of: http://identifiers.org/ec-code/2.3.1.16
name: RE1522
fast: false
notes: GENE_ASSOCIATION: (1892.1) or (3030.1) or (1962.1) or (3032.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.17 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:7775433,PMID:7923814,PMID:9568246,PMID:9920399 NOTES:
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110063#_0b938750_3a48_4159_b487_c1b6eb261657
is: Q16795
initial amount: NaN
is encoded by: hsa:4704
initial concentration: NaN
type: Species
name: NDUFA9
boundary condition: true
has only substance units: false
constant: false
is: SBO:0000252

metaM pydx5p e
has only substance units: false
name: pyridoxal 5'-phosphate(2-)
is: HMDB01491
initial amount: NaN
is: SBO:0000247
type: Species
notes: FORMULA: C8H8NO6P CHARGE: -2 INCHI: InChI=1S/C8H10NO6P/c1-5-8(11)7(3-10)6(2-9-5)4-15-16(12,13)14/h2-3,11H,4H2,1H3,(H2,12,13,14)/p-2 HEPATONET_1.0_ABBREVIATION: HC00028 EHMN_ABBREVIATION: C00018
boundary condition: false
is: CHEBI:597326
initial concentration: 1.0
constant: false

metaR 34DHPHEt
reactant: MODEL1310110063#
reversible: true
name: 3,4-Dihydroxy-L-phenylalanine transport
is described by: ECO:0000269
product: MODEL1310110063#
is: SBO:0000185
type: Reaction
modifier: MODEL1310110063#
fast: false
notes: GENE_ASSOCIATION: (117247.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:11827462 NOTES:NCD
kinetic law: MODEL1310110063#

http://identifiers.org/biomodels.db/MODEL1310110063#_ead49d3c_60d1_40f8_834e_2f3484c4ca3e
is encoded by: hsa:10327
initial amount: NaN
is: SBO:0000252
initial concentration: NaN
name: AKR1A1
constant: false
boundary condition: true
type: Species
has only substance units: false

metaR FAOXC161802m
name: Beta oxidation fatty acid
is version of: http://identifiers.org/ec-code/1.3.99.3
notes: GENE_ASSOCIATION: (34.1) or (35.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.74 Confidence Level: 4 AUTHORS: NOTES:_4 rounds of beta ox, 1 loss of degree of unsat -> only 3 fad oxidized c16:1 -> c8:0 4 step FAO lumped for 2 rounds also includes EC 1.1.1.35, 1.1.1.211, 1.3.3.6, 4.2.1.17, 4.2.1.74 NJ
modifier: MODEL1310110063#
is described by: ECO:0000269
reactant: MODEL1310110063#
kinetic law: MODEL1310110063#
is version of: http://identifiers.org/ec-code/1.3.8.1
product: MODEL1310110063#
is: SBO:0000176
type: Reaction
reversible: false
fast: false

metaM 2dp6mobq me m
initial amount: NaN
type: Species
is: CHEBI:50772
name: 2-decaprenyl-6-methoxy-3-methyl-1,4-benzoquinone
boundary condition: false
constant: false
has only substance units: false
notes: FORMULA: C58H88O3 CHARGE: 0 INCHI: InChI=1S/C58H88O3/c1-44(2)23-14-24-45(3)25-15-26-46(4)27-16-28-47(5)29-17-30-48(6)31-18-32-49(7)33-19-34-50(8)35-20-36-51(9)37-21-38-52(10)39-22-40-53(11)41-42-55-54(12)56(59)43-57(61-13)58(55)60/h23,25,27,29,31,33,35,37,39,41,43H,14-22,24,26,28,30,32,34,36,38,40,42H2,1-13H3/b45-25+,46-27+,47-29+,48-31+,49-33+,50-35+,51-37+,52-39+,53-41+
initial concentration: 1.0
is: SBO:0000247

metaM rib D e
initial concentration: 1.0
constant: false
is: CHEBI:16988
has only substance units: false
notes: FORMULA: C5H10O5 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00119
is: SBO:0000247
name: D-ribose
boundary condition: false
initial amount: NaN
type: Species
is: HMDB00283

metaR S3TASE1ly
notes: GENE_ASSOCIATION: SUBSYSTEM: Heparan sulfate degradation EC Number: 3.1.6.15 Confidence Level: 4 AUTHORS: PMID:7396957,PMID:8993162 NOTES:NCD
is: SBO:0000176
type: Reaction
is described by: ECO:0000000
reversible: true
name: N-acetylglucosamine-3-sulfatase, lysosomal
kinetic law: MODEL1310110063#
fast: false
reactant: MODEL1310110063#
product: MODEL1310110063#

metaM lald D c
type: Species
is: CHEBI:17167
constant: false
is: HMDB06458
boundary condition: false
is: SBO:0000247
name: (R)-lactaldehyde
has only substance units: false
initial concentration: 1.0
notes: FORMULA: C3H6O2 CHARGE: 0 INCHI: InChI=1S/C3H6O2/c1-3(5)2-4/h2-3,5H,1H3/t3-/m1/s1
initial amount: NaN

metaR sink pre prot LPAREN r RPAREN
kinetic law: MODEL1310110063#
reactant: MODEL1310110063#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: 2.4.99.9 Confidence Level: 1 AUTHORS: PMID:9822625 NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: glycophosphatidylinositol (GPI)-anchored protein precursor sink
type: Reaction

metaR GLNASNNaEx
is described by: ECO:0000269
reactant: MODEL1310110063#
is: SBO:0000185
name: L-glutamine/L-asparagine Na-dependent exchange (Gln-L in)
kinetic law: MODEL1310110063#
modifier: MODEL1310110063#
type: Reaction
notes: GENE_ASSOCIATION: (6510.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14530974 NOTES:SAB see Kanai and Hediger 2004 (2003), PMID 14530974
product: MODEL1310110063#
reversible: false
fast: false

metaM zymstnl r
boundary condition: false
has only substance units: false
is: CHEBI:16608
initial concentration: 1.0
initial amount: NaN
type: Species
is: HMDB06841
name: 5alpha-cholest-8-en-3beta-ol
notes: FORMULA: C27H46O CHARGE: 0 INCHI: InChI=1S/C27H46O/c1-18(2)7-6-8-19(3)23-11-12-24-22-10-9-20-17-21(28)13-15-26(20,4)25(22)14-16-27(23,24)5/h18-21,23-24,28H,6-17H2,1-5H3/t19-,20+,21+,23-,24+,26+,27-/m1/s1 EHMN_ABBREVIATION: C03845
constant: false
is: SBO:0000247

metaR PLA2 2e
product: MODEL1310110063#
type: Reaction
fast: false
is described by: ECO:0000000
modifier: MODEL1310110063#
reversible: false
reactant: MODEL1310110063#
is: SBO:0000176
kinetic law: MODEL1310110063#
notes: GENE_ASSOCIATION: (5322.1) or (5319.1) or (81579.1) or (64600.1) or (26279.1) or (5320.1) or (8399.1) or (30814.1) SUBSYSTEM: Glycerophospholipid metabolism EC Number: 3.1.1.4 Confidence Level: 4 AUTHORS: PMID:10455175,PMID:10681567,PMID:11031251,PMID:11112443,PMID:8300559,PMID:9188469,PMID:9272153,PMID:9886417 NOTES:phosphatidyl choline degradation NJ
name: phospholipase A2
is version of: http://identifiers.org/ec-code/3.1.1.4

http://identifiers.org/biomodels.db/MODEL1310110063#_a0124476_9e12_4eb9_9cbb_12d3cec147fe
is: O60476
name: MAN1A2
initial concentration: NaN
boundary condition: true
constant: false
has only substance units: false
is encoded by: hsa:10905
type: Species
is: SBO:0000252
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110063#_89d632bc_4973_477b_b3c7_8af9977577a7
boundary condition: true
type: Species
initial amount: NaN
is: Q6IBA0
is encoded by: hsa:4725
constant: false
has only substance units: false
is: SBO:0000252
name: NDUFS5
initial concentration: NaN

metaR r2022
type: Reaction
fast: false
kinetic law: MODEL1310110063#
modifier: MODEL1310110063#
reversible: false
is described by: ECO:0000000
product: MODEL1310110063#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.15
is: SBO:0000185
reactant: MODEL1310110063#
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110063#_3c1407ab_e208_4419_b8d6_0badfc7864e6
type: Species
constant: false
initial amount: NaN
has only substance units: false
is encoded by: hsa:11041
name: B3GNT1
initial concentration: NaN
boundary condition: true
is: SBO:0000252
is: O43505

http://identifiers.org/biomodels.db/MODEL1310110063#_b915e522_99b8_42e7_96e4_d0d0fff3104e
is encoded by: hsa:6307
has only substance units: false
is: SBO:0000252
boundary condition: true
type: Species
name: MSMO1
is: A8MYF6
initial concentration: NaN
constant: false
initial amount: NaN

metaM 2hexdtricoa x
is: HMDB02288
notes: FORMULA: C37H56N7O17P3S CHARGE: -4
initial concentration: 1.0
initial amount: NaN
boundary condition: false
name: 2,7,10-hexadecatrienoylcoa
constant: false
has only substance units: false
type: Species
is: SBO:0000247

metaR FAOXC142C122m
kinetic law: MODEL1310110063#
product: MODEL1310110063#
reactant: MODEL1310110063#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C14:2-->C12:2)m
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110063#_c538157a_315c_42b8_8bb7_f6d006764af0
boundary condition: true
initial concentration: NaN
has only substance units: false
type: Species
name: NDUFV1
is encoded by: hsa:4723
constant: false
is: E5KNH5
initial amount: NaN
is: SBO:0000252

metaM cspg e e
boundary condition: false
initial amount: NaN
is: SBO:0000247
is: C00106
has only substance units: false
is: CHEBI:17568
notes: FORMULA: C45H63N2O54S6X CHARGE: -8
name: chondroitin sulfate E (GalNAc4,6diS-GlcA) proteoglycan
constant: false
initial concentration: 1.0
is: HMDB00300
type: Species

metaR C3DCe
kinetic law: MODEL1310110063#
product: MODEL1310110063#
reactant: MODEL1310110063#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of malonyl carnitine into extra cellular space
type: Reaction

metaM ksi deg37 l
is: HMDB01354
initial amount: NaN
is: CHEBI:57455
has only substance units: false
boundary condition: false
type: Species
notes: FORMULA: C62H104N4O46 CHARGE: 0
initial concentration: 1.0
constant: false
name: keratan sulfate I, degradation product 37
is: SBO:0000247

metaR FAOXC102C101m
kinetic law: MODEL1310110063#
product: MODEL1310110063#
reactant: MODEL1310110063#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: reduction(C10:2-->C10:1)m
type: Reaction

metaM hpdca c
is: CHEBI:32366
constant: false
initial concentration: 1.0
notes: FORMULA: C17H33O2 CHARGE: -1 INCHI: InChI=1S/C17H34O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17(18)19/h2-16H2,1H3,(H,18,19)/p-1
is: SBO:0000247
boundary condition: false
initial amount: NaN
name: margarate
has only substance units: false
type: Species
is: HMDB02259

metaM HC00900 m
type: Species
notes: FORMULA: C4H4O4 CHARGE: -2 INCHI: InChI=1S/C4H6O4/c1-2(3(5)6)4(7)8/h2H,1H3,(H,5,6)(H,7,8) EHMN_ABBREVIATION: C02170
initial concentration: 1.0
initial amount: NaN
boundary condition: false
constant: false
is: CHEBI:30860
name: Methylmalonate
has only substance units: false
is: SBO:0000247

metaR r2330
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
fast: false
product: MODEL1310110063#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
reversible: true
reactant: MODEL1310110063#
is described by: ECO:0000000
type: Reaction
kinetic law: MODEL1310110063#
is: SBO:0000185

metaR PItn
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: NOTES:IT
type: Reaction
name: phosphate transport, nuclear
fast: false
is: SBO:0000185
product: MODEL1310110063#
reactant: MODEL1310110063#
kinetic law: MODEL1310110063#
is described by: ECO:0000000

metaR FAOXC164C163x
kinetic law: MODEL1310110063#
product: MODEL1310110063#
reactant: MODEL1310110063#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C16:4-->C16:3)x
type: Reaction

metaM pi x
name: hydrogenphosphate
notes: FORMULA: HO4P CHARGE: -2 INCHI: InChI=1S/H3O4P/c1-5(2,3)4/h(H3,1,2,3,4)/p-2 HEPATONET_1.0_ABBREVIATION: HC00019 EHMN_ABBREVIATION: C00009
initial concentration: 1.0
constant: false
is: HMDB00973
is: CHEBI:43474
initial amount: NaN
is: SBO:0000247
boundary condition: false
has only substance units: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110063#_2795ec50_019c_4a91_9233_eb528bbf13ab
has only substance units: false
is: SBO:0000252
is: Q63HM1
initial amount: NaN
type: Species
name: AFMID
is encoded by: hsa:125061
constant: false
boundary condition: true
initial concentration: NaN

metaR DM anth
kinetic law: MODEL1310110063#
reactant: MODEL1310110063#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: Demand for anthranilate
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110063#_78ca3d0b_c846_4559_ad36_32239adb3c8a
is: SBO:0000252
type: Species
name: _AA021081_1_r
initial concentration: NaN
initial amount: NaN
boundary condition: true
constant: false
is encoded by: hsa:AA021081
has only substance units: false

metaM pydx5p c
is: C00018
is: CHEBI:597326
notes: FORMULA: C8H8NO6P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00028 EHMN_ABBREVIATION: C00018
boundary condition: false
is: SBO:0000247
is: HMDB01491
initial concentration: 1.0
initial amount: NaN
type: Species
name: Pyridoxal 5'-phosphate
has only substance units: false
constant: false

http://identifiers.org/biomodels.db/MODEL1310110063#_b1022307_c5ca_4c60_89aa_7439835aeb4d
has only substance units: false
boundary condition: true
initial concentration: NaN
is encoded by: hsa:8803
is: SBO:0000297
name: SUCLG1:SUCLA2
type: Species
initial amount: NaN
constant: false
has part: E5KS60

metaR NRVNCCOAtx
is: SBO:0000185
kinetic law: MODEL1310110063#
type: Reaction
product: MODEL1310110063#
fast: false
reversible: true
name: fatty acid intracellular transport
reactant: MODEL1310110063#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: NOTES:interaction between peroxisomes and ER (some enzymes on the outer membrane) NJ

metaM 5aizc c
initial amount: NaN
is: SBO:0000247
notes: FORMULA: C9H11N3O9P CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC01347 EHMN_ABBREVIATION: C04751
is: CHEBI:58564
type: Species
has only substance units: false
name: 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate
is: C04751
constant: false
is: HMDB06273
boundary condition: false
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110063#_8f68d2dd_5bc2_4f6f_abde_b5ee40f652fa
type: Species
name: BAAT
initial amount: NaN
is: SBO:0000252
is: Q14032
boundary condition: true
is encoded by: hsa:570
has only substance units: false
constant: false
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110063#_6b4ceab8_c5d2_465b_b15b_6fa7356d79d3
boundary condition: true
type: Species
initial concentration: NaN
is: P25325
is encoded by: hsa:4357
is: SBO:0000252
initial amount: NaN
constant: false
has only substance units: false
name: MPST

metaR r2331
reversible: true
kinetic law: MODEL1310110063#
is: SBO:0000185
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
fast: false
is described by: ECO:0000000
type: Reaction
product: MODEL1310110063#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
reactant: MODEL1310110063#

metaM 4hpro LT c
constant: false
type: Species
has only substance units: false
is: SBO:0000247
name: trans-4-hydroxy-L-proline
boundary condition: false
notes: FORMULA: C5H9NO3 CHARGE: 0 INCHI: InChI=1S/C5H9NO3/c7-3-1-4(5(8)9)6-2-3/h3-4,6-7H,1-2H2,(H,8,9)/t3-,4+/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00690
initial amount: NaN
initial concentration: 1.0
is: CHEBI:18095
is: HMDB00725

http://identifiers.org/biomodels.db/MODEL1310110063#_5c8f2c0f_eb25_48ed_9af9_6c2161448bc1
initial amount: NaN
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:2582
is: Q38G75
type: Species
constant: false
boundary condition: true
has only substance units: false
name: GALE

metaM glx x
notes: FORMULA: C2H1O3 CHARGE: -1 INCHI: InChI=1S/C2H2O3/c3-1-2(4)5/h1H,(H,4,5)/p-1 EHMN_ABBREVIATION: C00048
name: glyoxylate
type: Species
has only substance units: false
is: HMDB00119
constant: false
initial amount: NaN
is: CHEBI:36655
is: SBO:0000247
initial concentration: 1.0
boundary condition: false

metaR AKR1D
product: MODEL1310110063#
kinetic law: MODEL1310110063#
name: aldo-keto reductase family 1, member D1 (delta 4-3-ketosteroid-5-beta-reductase)
is version of: http://identifiers.org/ec-code/1.3.1.3
modifier: MODEL1310110063#
reactant: MODEL1310110063#
notes: GENE_ASSOCIATION: (6718.1) SUBSYSTEM: Bile acid synthesis EC Number: 1.3.99.6 Confidence Level: 4 AUTHORS: NOTES:refs: uniprot, KEGG DW Russell bile acid synthesis review paper (see human recon journal citations) NJ
type: Reaction
reversible: false
fast: false
is: SBO:0000176
is described by: ECO:0000269

metaR r2332
reactant: MODEL1310110063#
type: Reaction
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
kinetic law: MODEL1310110063#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
fast: false
is: SBO:0000185
reversible: true
product: MODEL1310110063#

metaR r0022
notes: GENE_ASSOCIATION: (AA532636.1) or (2936.1) SUBSYSTEM: Glutathione metabolism EC Number: 1.8.1.7 Confidence Level: 0 AUTHORS: PMID:10781871,PMID:12821209,PMID:237878,PMID:31912,PMID:4380255,PMID:8981046,PMID:9621574 NOTES:
is: SBO:0000176
fast: false
modifier: MODEL1310110063#
product: MODEL1310110063#
type: Reaction
name: glutathione:NAD+ oxidoreductase Glutamate metabolism EC:1.8.1.7
reversible: true
reactant: MODEL1310110063#
is described by: ECO:0000000
kinetic law: MODEL1310110063#
is version of: http://identifiers.org/ec-code/1.8.1.7

http://identifiers.org/biomodels.db/MODEL1310110063#_b1dba505_c4fb_417b_b154_8e821a9f9062
is: Q13057
boundary condition: true
is encoded by: hsa:80347
is: SBO:0000252
constant: false
name: COASY
has only substance units: false
initial amount: NaN
initial concentration: NaN
type: Species

http://identifiers.org/biomodels.db/MODEL1310110063#_a3971ffc_9c5a_42d7_9d67_62f862bfec7d
initial amount: NaN
constant: false
is: E7ET30
name: AK3
boundary condition: true
type: Species
is: SBO:0000252
has only substance units: false
initial concentration: NaN
is encoded by: hsa:50808

metaM lac L c
is: HMDB00190
notes: FORMULA: C3H5O3 CHARGE: -1 INCHI: InChI=1S/C3H6O3/c1-2(4)3(5)6/h2,4H,1H3,(H,5,6)/p-1/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00177
initial amount: NaN
name: (S)-lactate
boundary condition: false
initial concentration: 1.0
constant: false
type: Species
is: SBO:0000247
is: CHEBI:16651
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110063#_09115480_9d34_48c5_88c0_9a3525803806
boundary condition: true
type: Species
has only substance units: false
initial concentration: NaN
is: Q6ZWT7
constant: false
is encoded by: hsa:129642
is: SBO:0000252
initial amount: NaN
name: MBOAT2

metaR EX c8crn
kinetic law: MODEL1310110063#
reactant: MODEL1310110063#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for octanoyl carnitine
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110063#_508cc13e_34a0_4db9_9db0_d0847dcbad73
has only substance units: false
is encoded by: hsa:4536
type: Species
initial amount: NaN
is: Q7GXY9
constant: false
initial concentration: NaN
boundary condition: true
name: ND2
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110063#_d4caad02_a7c6_4690_8598_4f900f912c56
constant: false
initial concentration: NaN
is encoded by: hsa:39
is: SBO:0000252
type: Species
boundary condition: true
has only substance units: false
is: Q9BWD1
initial amount: NaN
name: ACAT2

http://identifiers.org/biomodels.db/MODEL1310110063#_f43782ec_6b82_49fc_940e_033af9811019
boundary condition: true
initial concentration: NaN
initial amount: NaN
name: NDUFA8
has only substance units: false
constant: false
is encoded by: hsa:4702
is: SBO:0000252
type: Species
is: B1AM93

metaM ksii core4 deg4 l
is: HMDB01354
notes: FORMULA: C66H108N6O48SX CHARGE: -1
is: CHEBI:57455
has only substance units: false
initial amount: NaN
name: keratan sulfate II (core 4-linked), degradation product 4
is: SBO:0000247
constant: false
boundary condition: false
type: Species
initial concentration: 1.0

metaM hexdtrcoa m
initial concentration: 1.0
constant: false
boundary condition: false
is: HMDB02288
name: 7,10,13-hexadecatrienoylcoa
has only substance units: false
type: Species
is: SBO:0000247
notes: FORMULA: C37H56N7O17P3S CHARGE: -4
initial amount: NaN

metaM hpdca e
name: margarate
boundary condition: false
type: Species
initial amount: NaN
has only substance units: false
initial concentration: 1.0
notes: FORMULA: C17H33O2 CHARGE: -1 INCHI: InChI=1S/C17H34O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17(18)19/h2-16H2,1H3,(H,18,19)/p-1
constant: false
is: SBO:0000247
is: HMDB02259
is: CHEBI:32366

metaR CRVNCtr
is: SBO:0000185
type: Reaction
reversible: true
reactant: MODEL1310110063#
name: fatty acid transport via diffusion
kinetic law: MODEL1310110063#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11788354,PMID:12864740 NOTES:NJ
is described by: ECO:0000000
fast: false
product: MODEL1310110063#

metaR RE2986X
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/1.1.1.35
reversible: true
name: RE2986
is: SBO:0000176
kinetic law: MODEL1310110063#
modifier: MODEL1310110063#
product: MODEL1310110063#
type: Reaction
reactant: MODEL1310110063#
fast: false
notes: GENE_ASSOCIATION: (1962.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.17 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:10970790,PMID:7775433 NOTES:

metaR r2333
product: MODEL1310110063#
is described by: ECO:0000000
reversible: true
reactant: MODEL1310110063#
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
kinetic law: MODEL1310110063#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
fast: false
is: SBO:0000185
type: Reaction

metaR M16N4Tg
notes: GENE_ASSOCIATION: SUBSYSTEM: N-glycan synthesis EC Number: 2.4.1.201 Confidence Level: 0 AUTHORS: NOTES:NCD
reactant: MODEL1310110063#
is: SBO:0000176
type: Reaction
fast: false
name: alpha-1,6-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase
product: MODEL1310110063#
kinetic law: MODEL1310110063#
is described by: ECO:0000000
reversible: false

metaR HSPGtly
type: Reaction
name: heparan sulfate transport, extracellular to lysosome
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 2 AUTHORS: NOTES:NCD
reversible: false
product: MODEL1310110063#
is described by: ECO:0000000
is: SBO:0000185
kinetic law: MODEL1310110063#
reactant: MODEL1310110063#

metaM apoC Lys c
boundary condition: false
is: CHEBI:32551
notes: FORMULA: C6H13N2OX CHARGE: 0
initial amount: NaN
is: SBO:0000247
type: Species
constant: false
is: HMDB00182
initial concentration: 1.0
name: Apocarboxylase (Lys residue)
has only substance units: false

metaM 4hpro LT e
name: trans-4-hydroxy-L-proline
boundary condition: false
initial amount: NaN
constant: false
is: HMDB00725
is: SBO:0000247
type: Species
initial concentration: 1.0
notes: FORMULA: C5H9NO3 CHARGE: 0 INCHI: InChI=1S/C5H9NO3/c7-3-1-4(5(8)9)6-2-3/h3-4,6-7H,1-2H2,(H,8,9)/t3-,4+/m1/s1
has only substance units: false

metaR r0021
reactant: MODEL1310110063#
notes: GENE_ASSOCIATION: (AV717590.1) or (953.1) or (954.1) or (956.1) or (377841.1) SUBSYSTEM: Glutathione metabolism EC Number: 1.8.1.7 Confidence Level: 0 AUTHORS: PMID:10781871,PMID:12821209,PMID:237878,PMID:31912,PMID:4380255,PMID:8981046,PMID:9621574 NOTES:IT - fixed proton
name: glutathione:NAD+ oxidoreductase Glutamate metabolism EC:1.8.1.7
is version of: http://identifiers.org/ec-code/3.6.1.5
modifier: MODEL1310110063#
kinetic law: MODEL1310110063#
is described by: ECO:0000000
type: Reaction
product: MODEL1310110063#
fast: false
is: SBO:0000176
reversible: true

metaM dcsptn1coa c
initial amount: NaN
is: SBO:0000247
boundary condition: false
is: HMDB06513
initial concentration: 1.0
notes: FORMULA: C43H64N7O17P3S CHARGE: -4 INCHI: InChI=1/C43H68N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-34(52)71-27-26-45-33(51)24-25-46-41(55)38(54)43(2,3)29-64-70(61,62)67-69(59,60)63-28-32-37(66-68(56,57)58)36(53)42(65-32)50-31-49-35-39(44)47-30-48-40(35)50/h8-9,11-12,14-15,17-18,20-21,30-32,36-38,42,53-54H,4-7,10,13,16,19,22-29H2,1-3H3,(H,45,51)(H,46,55)(H,59,60)(H,61,62)(H2,44,47,48)(H2,56,57,58)/b9-8-,12-11-,15-14-,18-17-,21-20-/t32-,36-,37?,38+,42-/m1/s1
has only substance units: false
constant: false
type: Species
is: http://identifiers.org/pubchem.compound/47205483
is: C16173
name: docosa-4,7,10,13,16-pentaenoyl coenzyme A

metaR DTTPtn
product: MODEL1310110063#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: NOTES:IT
type: Reaction
kinetic law: MODEL1310110063#
reactant: MODEL1310110063#
is described by: ECO:0000000
reversible: true
fast: false
name: dTTP diffusion in nucleus
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110063#_36b06b89_2e6a_4f6f_b15b_bfa756c6f6b4
initial amount: NaN
has only substance units: false
is encoded by: hsa:6901
initial concentration: NaN
boundary condition: true
is: Q16635
constant: false
is: SBO:0000252
name: TAZ
type: Species

http://identifiers.org/biomodels.db/MODEL1310110063#_e5be0038_4d3c_40ae_9b81_e350222f5527
constant: false
initial amount: NaN
has only substance units: false
name: ESPN
is encoded by: hsa:83715
initial concentration: NaN
is: SBO:0000252
type: Species
boundary condition: true
is: B1AK53

metaM xylu L c
initial amount: NaN
is: SBO:0000247
notes: FORMULA: C5H10O5 CHARGE: 0 INCHI: InChI=1S/C5H10O5/c6-1-3(8)5(10)4(9)2-7/h3,5-8,10H,1-2H2/t3-,5+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00267
is: CHEBI:17399
name: L-xylulose
boundary condition: false
is: HMDB00751
constant: false
initial concentration: 1.0
has only substance units: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110063#_8542c189_ade7_4bdb_87ff_317be10d51d9
constant: false
is: Q9Y2D0
type: Species
name: CA5B
initial amount: NaN
has only substance units: false
is encoded by: hsa:11238
initial concentration: NaN
is: SBO:0000252
boundary condition: true

metaM dlnlcgcoa m
is: SBO:0000247
constant: false
is: CHEBI:27979
initial amount: NaN
initial concentration: 1.0
type: Species
name: dihomo-gamma-linolenyl coenzyme A
boundary condition: false
notes: FORMULA: C41H64N7O17P3S CHARGE: -4 INCHI: InChI=1S/C41H68N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-32(50)69-25-24-43-31(49)22-23-44-39(53)36(52)41(2,3)27-62-68(59,60)65-67(57,58)61-26-30-35(64-66(54,55)56)34(51)40(63-30)48-29-47-33-37(42)45-28-46-38(33)48/h8-9,11-12,14-15,28-30,34-36,40,51-52H,4-7,10,13,16-27H2,1-3H3,(H,43,49)(H,44,53)(H,57,58)(H,59,60)(H2,42,45,46)(H2,54,55,56)/b9-8-,12-11-,15-14-/t30-,34-,35-,36+,40-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC02102
has only substance units: false

metaR ABTD
is: SBO:0000176
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Pentose phosphate pathway EC Number: 1.1.1.12 Confidence Level: 2 AUTHORS: PMID:12359133,PMID:13922173,PMID:15234337 NOTES:NCD
is described by: ECO:0000000
reactant: MODEL1310110063#
type: Reaction
reversible: true
name: L-arabinitol 4-dehydrogenase
product: MODEL1310110063#
kinetic law: MODEL1310110063#

http://identifiers.org/biomodels.db/MODEL1310110063#_55b48ddf_d68f_42d3_832d_5861cc926d45
name: PIK3CA:PIK3R1
initial concentration: NaN
type: Species
has part: P27986
constant: false
initial amount: NaN
boundary condition: true
is: SBO:0000297
is encoded by: hsa:5295
has only substance units: false

metaR HISSNAT5tc
kinetic law: MODEL1310110063#
product: MODEL1310110063#
reactant: MODEL1310110063#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: Transport of L-Histidine into the cell coupled with co-transport with Sodium and counter transport with proton by SNAT5 transporter.
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110063#_34169c47_7dfd_4bb1_a7ce_bd35243728f0
is encoded by: hsa:5315
name: PKM2
has only substance units: false
is: SBO:0000252
is: P14618
constant: false
boundary condition: true
initial amount: NaN
initial concentration: NaN
type: Species

metaR r1828
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
product: MODEL1310110063#
type: Reaction
reactant: MODEL1310110063#
reversible: false
kinetic law: MODEL1310110063#
name: Y+LAT2 Utilized transport
fast: false
is described by: ECO:0000000
modifier: MODEL1310110063#
is: SBO:0000185

metaR EX leuktrF4 LPAREN e RPAREN
kinetic law: MODEL1310110063#
reactant: MODEL1310110063#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: leukotriene F4 exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110063#_704a214f_efad_4bc9_b1fd_12642b22ba21
is: Q9BY49
boundary condition: true
initial concentration: NaN
has only substance units: false
constant: false
type: Species
name: PECR
initial amount: NaN
is encoded by: hsa:55825
is: SBO:0000252

metaR ACACT1x
type: Reaction
fast: false
is described by: ECO:0000134
reactant: MODEL1310110063#
reversible: false
kinetic law: MODEL1310110063#
product: MODEL1310110063#
is version of: http://identifiers.org/ec-code/2.3.1.9
name: acetyl-CoA C-acetyltransferase, mitochondrial
modifier: MODEL1310110063#
notes: GENE_ASSOCIATION: (39.1) SUBSYSTEM: Cholesterol metabolism EC Number: 2.3.1.9 Confidence Level: 4 AUTHORS: PMID:11108725 NOTES:NCD NJ - added peroxisomal version
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110063#_38ffc56c_9fd7_4f6a_880c_81ab530bc42c
name: PROSC
initial concentration: NaN
constant: false
is encoded by: hsa:11212
is: SBO:0000252
boundary condition: true
type: Species
has only substance units: false
is: O94903
initial amount: NaN

metaR GluForTx
fast: false
is described by: ECO:0000269
type: Reaction
product: MODEL1310110063#
is version of: http://identifiers.org/ec-code/2.1.2.5
reactant: MODEL1310110063#
notes: GENE_ASSOCIATION: (10841.1) or (10841.2) SUBSYSTEM: Histidine metabolism EC Number: 2.1.2.5 Confidence Level: 4 AUTHORS: PMID:12815595 NOTES:SAB
reversible: false
modifier: MODEL1310110063#
kinetic law: MODEL1310110063#
is: SBO:0000176
name: Glutamate formimidoyltransferase

http://identifiers.org/biomodels.db/MODEL1310110063#_51109f23_ca2b_4939_9953_82fe0271c8dc
initial concentration: NaN
name: SLC3A2:SLC7A6
boundary condition: true
is encoded by: hsa:9057
has part: Q92536
initial amount: NaN
has only substance units: false
constant: false
is: SBO:0000297
type: Species

metaM 3ttetddcoacrn c
constant: false
notes: FORMULA: C21H37NO5 CHARGE: 0
initial concentration: 1.0
is: SBO:0000247
initial amount: NaN
is: HMDB02014
boundary condition: false
has only substance units: false
type: Species
name: 3-hydroxy trans5,8tetradecadienoyl carnitine

metaR r0242
is: SBO:0000176
is described by: ECO:0000000
product: MODEL1310110063#
fast: false
reversible: true
is version of: http://identifiers.org/ec-code/6.2.1.1
type: Reaction
modifier: MODEL1310110063#
notes: GENE_ASSOCIATION: (84532.1) or (55902.1) or (79611.1) SUBSYSTEM: Unassigned EC Number: 3.1.3.1 Confidence Level: 0 AUTHORS: PMID:1730777,PMID:3042787 NOTES:
name: Glycerone phosphate phosphohydrolase (alkaline optimum) EC:3.1.3.1
kinetic law: MODEL1310110063#
reactant: MODEL1310110063#

metaR r1078
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:10049700,PMID:10574970,PMID:11389679,PMID:11557028,PMID:11564694,PMID:12824232,PMID:12930836,PMID:14574404,PMID:16288981,PMID:911815 NOTES:
kinetic law: MODEL1310110063#
product: MODEL1310110063#
is: SBO:0000185
reversible: false
fast: false
is described by: ECO:0000000
type: Reaction
name: Vesicular transport
reactant: MODEL1310110063#

metaR r1827
is described by: ECO:0000000
modifier: MODEL1310110063#
reactant: MODEL1310110063#
reversible: false
kinetic law: MODEL1310110063#
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
fast: false
type: Reaction
is: SBO:0000185
product: MODEL1310110063#
name: Y+LAT2 Utilized transport

metaM CE2422 m
boundary condition: false
has only substance units: false
constant: false
is: CHEBI:28387
is: SBO:0000247
is: HMDB11123
type: Species
initial amount: NaN
notes: FORMULA: C37H56N7O18P3S CHARGE: -4 INCHI: InChI=1/C37H60N7O18P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-25(45)20-28(47)66-19-18-39-27(46)16-17-40-35(50)32(49)37(2,3)22-59-65(56,57)62-64(54,55)58-21-26-31(61-63(51,52)53)30(48)36(60-26)44-24-43-29-33(38)41-23-42-34(29)44/h8-9,11-12,23-24,26,30-32,36,48-49H,4-7,10,13-22H2,1-3H3,(H,39,46)(H,40,50)(H,54,55)(H,56,57)(H2,38,41,42)(H2,51,52,53)/p-4/b9-8-,12-11-/t26-,30+,31+,32u,36-/m0/s1 EHMN_ABBREVIATION: CE2422
initial concentration: 1.0
name: 3-oxo-cis,cis-7,10-hexadecadienoyl-CoA

http://identifiers.org/biomodels.db/MODEL1310110063#_37c8ac59_77b8_467c_b31b_e64919e69f3d
initial concentration: NaN
is: SBO:0000252
type: Species
initial amount: NaN
has only substance units: false
is encoded by: hsa:771
constant: false
boundary condition: true
name: CA12

metaM ksii core4 l
notes: FORMULA: C89H142N7O72S3X CHARGE: -4
constant: false
name: keratan sulfate II (core 4-linked)
is: HMDB01644
has only substance units: false
initial concentration: 1.0
initial amount: NaN
is: SBO:0000247
type: Species
boundary condition: false
is: CHEBI:17140

metaR FAOXC10C8x
kinetic law: MODEL1310110063#
product: MODEL1310110063#
reactant: MODEL1310110063#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C10-->C8)x
type: Reaction

metaR r2341
name: Organic anion transporter 5 Utilized transport
reactant: MODEL1310110063#
is: SBO:0000185
kinetic law: MODEL1310110063#
product: MODEL1310110063#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
type: Reaction
reversible: true
fast: false

metaM leuktrE4 c
initial amount: NaN
name: leukotriene E4(1-)
initial concentration: 1.0
is: SBO:0000247
is: CHEBI:57462
type: Species
has only substance units: false
constant: false
notes: FORMULA: C23H36NO5S CHARGE: -1 INCHI: InChI=1S/C23H37NO5S/c1-2-3-4-5-6-7-8-9-10-11-12-13-16-21(30-18-19(24)23(28)29)20(25)15-14-17-22(26)27/h6-7,9-13,16,19-21,25H,2-5,8,14-15,17-18,24H2,1H3,(H,26,27)(H,28,29)/p-1/b7-6-,10-9-,12-11+,16-13+/t19-,20-,21+/m0/s1 EHMN_ABBREVIATION: C05952
boundary condition: false
is: HMDB02200

http://identifiers.org/biomodels.db/MODEL1310110063#_5af99965_f5d5_4583_a87a_c6970e648af3
is encoded by: hsa:2678
is: P19440
type: Species
constant: false
boundary condition: true
is: SBO:0000252
name: GGT1
initial concentration: NaN
has only substance units: false
initial amount: NaN

metaM idp e
constant: false
boundary condition: false
name: IDP(3-)
initial concentration: 1.0
has only substance units: false
type: Species
notes: FORMULA: C10H11N4O11P2 CHARGE: -3 INCHI: InChI=1S/C10H14N4O11P2/c15-6-4(1-23-27(21,22)25-26(18,19)20)24-10(7(6)16)14-3-13-5-8(14)11-2-12-9(5)17/h2-4,6-7,10,15-16H,1H2,(H,21,22)(H,11,12,17)(H2,18,19,20)/p-3/t4-,6-,7-,10-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00104 EHMN_ABBREVIATION: C00104
is: HMDB03335
is: SBO:0000247
is: CHEBI:58280
initial amount: NaN

metaR EX dlnlcg LPAREN e RPAREN
kinetic law: MODEL1310110063#
reactant: MODEL1310110063#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: dihomo-gamma-linolenic acid (n-6) exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110063#_183f2e9a_6e97_423b_925e_4e5790eb26d2
boundary condition: true
has only substance units: false
initial concentration: NaN
is: SBO:0000252
name: SLC2A7
is: Q6PXP3
is encoded by: hsa:155184
type: Species
constant: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110063#_43bac94f_3066_4297_b962_456be5e58132
constant: false
is: E9PEN2
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:11320
name: MGAT4A
is: SBO:0000252
has only substance units: false
boundary condition: true
type: Species

metaR GLCNACPT U
reactant: MODEL1310110063#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (1798.1) or (1798.2) SUBSYSTEM: N-glycan synthesis EC Number: 2.7.8.15 Confidence Level: 0 AUTHORS: NOTES:NCD
modifier: MODEL1310110063#
is version of: http://identifiers.org/ec-code/2.7.8.15
product: MODEL1310110063#
fast: false
name: UDP-GlcNAc:dolichol-phosphate GlcNAc phosphotransferase (uterus)
reversible: false
type: Reaction
kinetic law: MODEL1310110063#
is: SBO:0000176

metaM thf c
is: C00101
is: HMDB01846
constant: false
initial concentration: 1.0
name: 5,6,7,8-Tetrahydrofolate
is: SBO:0000247
initial amount: NaN
type: Species
is: CHEBI:57453
has only substance units: false
notes: FORMULA: C19H21N7O6 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00102 EHMN_ABBREVIATION: C00101
boundary condition: false

metaR M4MPDOL Uter
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: N-glycan synthesis EC Number: Confidence Level: 0 AUTHORS: NOTES:
name: m4mpdol flippase
reversible: false
type: Reaction
is described by: ECO:0000000
is: SBO:0000185
reactant: MODEL1310110063#
product: MODEL1310110063#
kinetic law: MODEL1310110063#

metaR r1106
is described by: ECO:0000000
type: Reaction
kinetic law: MODEL1310110063#
reactant: MODEL1310110063#
fast: false
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:10049700,PMID:10574970,PMID:11389679,PMID:11557028,PMID:11564694,PMID:12824232,PMID:12930836,PMID:14574404,PMID:16288981,PMID:911815 NOTES:
product: MODEL1310110063#
reversible: true
name: Postulated transport reaction

http://identifiers.org/biomodels.db/MODEL1310110063#_3a72b511_74bf_4de8_bd0d_eabc3c370493
constant: false
initial concentration: NaN
is: E7EUT4
boundary condition: true
type: Species
has only substance units: false
is encoded by: hsa:2597
name: GAPDH
initial amount: NaN
is: SBO:0000252

metaM lac L x
name: (S)-lactate
initial concentration: 1.0
is: SBO:0000247
is: HMDB00190
has only substance units: false
boundary condition: false
is: CHEBI:16651
notes: FORMULA: C3H5O3 CHARGE: -1 INCHI: InChI=1S/C3H6O3/c1-2(4)3(5)6/h2,4H,1H3,(H,5,6)/p-1/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00177
initial amount: NaN
constant: false
type: Species

metaR EX HC02206 LPAREN e RPAREN
kinetic law: MODEL1310110063#
reactant: MODEL1310110063#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: prostaglandin C1(1-) exchange
type: Reaction

metaR ADKd
notes: GENE_ASSOCIATION: (26289.2) or (26289.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.3 Confidence Level: 4 AUTHORS: PMID:10215863 NOTES:Inorganic triphosphate can also act as donor This form was added for Staph based on KEGG evidence (SAB)
modifier: MODEL1310110063#
reactant: MODEL1310110063#
product: MODEL1310110063#
reversible: true
fast: false
kinetic law: MODEL1310110063#
type: Reaction
is version of: http://identifiers.org/ec-code/2.7.4.3
name: adenylate kinase (d form)
is described by: ECO:0000269
is: SBO:0000176

metaR FAOXC161C161OHm
kinetic law: MODEL1310110063#
product: MODEL1310110063#
reactant: MODEL1310110063#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: production of 3-hydroxyhexadecenoylcoA
type: Reaction

metaR CYSGLTH
fast: false
product: MODEL1310110063#
notes: GENE_ASSOCIATION: SUBSYSTEM: Methionine and cysteine metabolism EC Number: 1.8.4.4 Confidence Level: 4 AUTHORS: PMID:15189131,PMID:932033 NOTES:reaction according to KEGG MM
name: Glutathione:cystine oxidoreductase
kinetic law: MODEL1310110063#
is described by: ECO:0000000
is: SBO:0000176
reversible: true
type: Reaction
reactant: MODEL1310110063#

http://identifiers.org/biomodels.db/MODEL1310110063#_c1b86ea6_ae99_4a2d_869b_93082b46d40d
type: Species
has only substance units: false
is encoded by: hsa:107
is: Q08828
constant: false
name: ADCY1
boundary condition: true
is: SBO:0000252
initial amount: NaN
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110063#_dcbafa88_4a28_43b4_9603_5efbec4565d5
name: _AI601100_1_m
initial amount: NaN
constant: false
is: SBO:0000252
initial concentration: NaN
has only substance units: false
is encoded by: hsa:AI601100
type: Species
boundary condition: true

metaR r2017
is described by: ECO:0000000
fast: false
reversible: false
kinetic law: MODEL1310110063#
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
type: Reaction
modifier: MODEL1310110063#
reactant: MODEL1310110063#
is: SBO:0000185
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.15
product: MODEL1310110063#

http://identifiers.org/biomodels.db/MODEL1310110063#_6dbd0a2a_db7c_40f2_9fa1_0faaecedce98
is: SBO:0000252
type: Species
is encoded by: hsa:515
has only substance units: false
is: P24539
constant: false
initial concentration: NaN
initial amount: NaN
name: ATP5F1
boundary condition: true

metaR r1829
reactant: MODEL1310110063#
type: Reaction
modifier: MODEL1310110063#
fast: false
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is: SBO:0000185
reversible: false
kinetic law: MODEL1310110063#
is described by: ECO:0000000
product: MODEL1310110063#
name: Y+LAT2 Utilized transport

metaM h g
notes: FORMULA: H CHARGE: 1 INCHI: InChI=1S/p+1/i/hH HEPATONET_1.0_ABBREVIATION: HC00083 EHMN_ABBREVIATION: C00080
has only substance units: false
initial concentration: 1.0
boundary condition: false
constant: false
is: SBO:0000247
name: proton
type: Species
initial amount: NaN
is: CHEBI:24636

metaR CHOLESTle
is described by: ECO:0000134
is: SBO:0000176
notes: GENE_ASSOCIATION: (3988.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
name: hydrolysis of cholesterol ester by cholesterol esterase
modifier: MODEL1310110063#
type: Reaction
reactant: MODEL1310110063#
product: MODEL1310110063#
is version of: http://identifiers.org/ec-code/3.1.1.13
fast: false
reversible: false
kinetic law: MODEL1310110063#

metaM fprica c
constant: false
notes: FORMULA: C10H13N4O9P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC01344 EHMN_ABBREVIATION: C04734
initial amount: NaN
is: C04734
is: HMDB01439
name: 5-Formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide
boundary condition: false
is: CHEBI:58467
is: SBO:0000247
has only substance units: false
type: Species
initial concentration: 1.0

metaR EX bilglcur LPAREN e RPAREN
kinetic law: MODEL1310110063#
reactant: MODEL1310110063#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for blirubin mono-glucuronide
type: Reaction

metaM idp c
type: Species
is: SBO:0000247
is: CHEBI:58280
boundary condition: false
has only substance units: false
notes: FORMULA: C10H11N4O11P2 CHARGE: -3 INCHI: InChI=1S/C10H14N4O11P2/c15-6-4(1-23-27(21,22)25-26(18,19)20)24-10(7(6)16)14-3-13-5-8(14)11-2-12-9(5)17/h2-4,6-7,10,15-16H,1H2,(H,21,22)(H,11,12,17)(H2,18,19,20)/p-3/t4-,6-,7-,10-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00104 EHMN_ABBREVIATION: C00104
name: IDP(3-)
is: HMDB03335
constant: false
initial concentration: 1.0
initial amount: NaN

metaM ak2lgchol hs e
type: Species
has only substance units: false
constant: false
notes: FORMULA: C10H21O5NPFULLR CHARGE: 0 EHMN_ABBREVIATION: C04317
name: 1-alkyl 2-lysoglycerol 3-phosphocholine
is: SBO:0000247
initial amount: NaN
boundary condition: false
is: C04317
is: http://identifiers.org/pubchem.compound/6975
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110063#_1b7faa26_ffe9_4180_8ae8_3ac6e276f582
name: CMPK1
type: Species
initial amount: NaN
is encoded by: hsa:51727
is: B2R6S5
initial concentration: NaN
constant: false
has only substance units: false
is: SBO:0000252
boundary condition: true

metaR 5MTHFt
modifier: MODEL1310110063#
notes: GENE_ASSOCIATION: (2348.5) or (2348.3) or (2348.1) or (2348.6) or (2352.1) or (2348.4) or (2348.2) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:15094208 NOTES:IT
product: MODEL1310110063#
is: SBO:0000185
type: Reaction
fast: false
kinetic law: MODEL1310110063#
is described by: ECO:0000269
name: 5-Methyltetrahydrofolate transport via receptor binding and protolysis
reactant: MODEL1310110063#
reversible: true

metaR sink c101coa LPAREN c RPAREN
kinetic law: MODEL1310110063#
reactant: MODEL1310110063#
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: C101COASINK
type: Reaction

metaM leuktrE4 e
boundary condition: false
name: leukotriene E4(1-)
type: Species
is: SBO:0000247
is: CHEBI:57462
constant: false
initial concentration: 1.0
has only substance units: false
notes: FORMULA: C23H36NO5S CHARGE: -1 INCHI: InChI=1S/C23H37NO5S/c1-2-3-4-5-6-7-8-9-10-11-12-13-16-21(30-18-19(24)23(28)29)20(25)15-14-17-22(26)27/h6-7,9-13,16,19-21,25H,2-5,8,14-15,17-18,24H2,1H3,(H,26,27)(H,28,29)/p-1/b7-6-,10-9-,12-11+,16-13+/t19-,20-,21+/m0/s1 EHMN_ABBREVIATION: C05952
is: HMDB02200
initial amount: NaN

metaM dd2coa c
is: SBO:0000247
initial concentration: 1.0
type: Species
has only substance units: false
constant: false
notes: FORMULA: C33H52N7O17P3S CHARGE: -4
boundary condition: false
name: trans-Dodec-2-enoyl-CoA
is: HMDB03712
initial amount: NaN

metaR r1977
modifier: MODEL1310110063#
kinetic law: MODEL1310110063#
fast: false
is described by: ECO:0000000
name: Y+LAT2 Utilized transport
type: Reaction
reactant: MODEL1310110063#
is: SBO:0000185
reversible: false
product: MODEL1310110063#
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:

metaM gtp n
initial concentration: 1.0
has only substance units: false
boundary condition: false
name: GTP(4-)
notes: FORMULA: C10H12N5O14P3 CHARGE: -4 INCHI: InChI=1S/C10H16N5O14P3/c11-10-13-7-4(8(18)14-10)12-2-15(7)9-6(17)5(16)3(27-9)1-26-31(22,23)29-32(24,25)28-30(19,20)21/h2-3,5-6,9,16-17H,1H2,(H,22,23)(H,24,25)(H2,19,20,21)(H3,11,13,14,18)/p-4/t3-,5-,6-,9-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00051 EHMN_ABBREVIATION: C00044
is: SBO:0000247
initial amount: NaN
is: HMDB01273
is: CHEBI:37565
constant: false
type: Species

metaM gmp e
is: SBO:0000247
boundary condition: false
is: CHEBI:58115
is: HMDB01397
notes: FORMULA: C10H12N5O8P CHARGE: -2 INCHI: InChI=1S/C10H14N5O8P/c11-10-13-7-4(8(18)14-10)12-2-15(7)9-6(17)5(16)3(23-9)1-22-24(19,20)21/h2-3,5-6,9,16-17H,1H2,(H2,19,20,21)(H3,11,13,14,18)/p-2/t3-,5-,6-,9-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00141 EHMN_ABBREVIATION: C00144
name: GMP(3-)
has only substance units: false
type: Species
initial amount: NaN
initial concentration: 1.0
constant: false

metaR r0475
is described by: ECO:0000000
reactant: MODEL1310110063#
name: 2-Deoxyadenosine 5-diphosphate:oxidized-thioredoxin 2-oxidoreductase Purine metabolism EC:1.17.4.1
notes: GENE_ASSOCIATION: SUBSYSTEM: Nucleotide interconversion EC Number: 1.17.4.1 Confidence Level: 0 AUTHORS: PMID:6121703,PMID:8074691 NOTES:
reversible: true
kinetic law: MODEL1310110063#
type: Reaction
product: MODEL1310110063#
fast: false
is: SBO:0000176

metaR DOLPMT2 Uer
is: SBO:0000176
is described by: ECO:0000000
name: dolichyl-phosphate-mannose-glycolipid alpha-mannosyltransferase (uterus)
kinetic law: MODEL1310110063#
reversible: false
product: MODEL1310110063#
type: Reaction
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: N-glycan synthesis EC Number: 2.4.1.130 Confidence Level: 0 AUTHORS: NOTES:
reactant: MODEL1310110063#

metaM cspg e l
is: CHEBI:36005
constant: false
is: HMDB02183
type: Species
has only substance units: false
notes: FORMULA: C45H63N2O54S6X CHARGE: -8
initial concentration: 1.0
name: chondroitin sulfate E (GalNAc4,6diS-GlcA) proteoglycan
initial amount: NaN
is: SBO:0000247
boundary condition: false

metaM hdca l
is: CHEBI:7896
has only substance units: false
is: HMDB00220
name: palmitate
type: Species
constant: false
initial amount: NaN
initial concentration: 1.0
is: SBO:0000247
boundary condition: false
notes: FORMULA: C16H31O2 CHARGE: -1 INCHI: InChI=1S/C16H32O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16(17)18/h2-15H2,1H3,(H,17,18)/p-1 HEPATONET_1.0_ABBREVIATION: HC00226 EHMN_ABBREVIATION: C00249

metaM spc hs e
is: SBO:0000247
has only substance units: false
name: sphingosylphosphorylcholine
constant: false
initial concentration: 1.0
type: Species
initial amount: NaN
boundary condition: false
notes: FORMULA: C23H50N2O5P CHARGE: 1 INCHI: InChI=1S/C23H49N2O5P/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-23(26)22(24)21-30-31(27,28)29-20-19-25(2,3)4/h17-18,22-23,26H,5-16,19-21,24H2,1-4H3/b18-17+/t22-,23+/m1/s1
is: http://identifiers.org/pubchem.compound/5311445

http://identifiers.org/biomodels.db/MODEL1310110063#_b9b4920f_a5c8_4a48_9e64_bb136a89165e
constant: false
has only substance units: false
is encoded by: hsa:341947
initial concentration: NaN
boundary condition: true
is: SBO:0000252
name: COX8C
type: Species
initial amount: NaN
is: Q7Z4L0

http://identifiers.org/biomodels.db/MODEL1310110063#_c89cd973_3241_481a_9031_14f3c4c00e74
is: Q53Y41
initial amount: NaN
is: SBO:0000252
boundary condition: true
type: Species
is encoded by: hsa:1644
name: DDC
constant: false
has only substance units: false
initial concentration: NaN

metaR EX hista LPAREN e RPAREN
kinetic law: MODEL1310110063#
reactant: MODEL1310110063#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Histamine exchange
type: Reaction

metaM HC02214 e
boundary condition: false
has only substance units: false
is: CHEBI:28852
name: prostaglandin-f1alpha
type: Species
initial amount: NaN
constant: false
notes: FORMULA: C20H35O5 CHARGE: -1 INCHI: InChI=1S/C20H36O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h12-13,15-19,21-23H,2-11,14H2,1H3,(H,24,25)/b13-12+/t15-,16+,17+,18-,19+/m0/s1
is: SBO:0000247
initial concentration: 1.0

metaM dheas c
has only substance units: false
notes: FORMULA: C19H27O5S CHARGE: -1 INCHI: InChI=1S/C19H28O5S/c1-18-9-7-13(24-25(21,22)23)11-12(18)3-4-14-15-5-6-17(20)19(15,2)10-8-16(14)18/h3,13-16H,4-11H2,1-2H3,(H,21,22,23)/p-1/t13-,14-,15-,16-,18-,19-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01314 EHMN_ABBREVIATION: C04555
type: Species
is: SBO:0000247
initial amount: NaN
is: HMDB01032
name: 3beta-hydroxyandrost-5-en-17-one 3-sulfate(1-)
is: CHEBI:57905
initial concentration: 1.0
constant: false
boundary condition: false

metaM gtp m
type: Species
has only substance units: false
name: GTP
is: CHEBI:37565
is: C00044
is: SBO:0000247
initial amount: NaN
initial concentration: 1.0
boundary condition: false
is: HMDB01273
notes: FORMULA: C10H12N5O14P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00051 EHMN_ABBREVIATION: C00044
constant: false

metaM h e
is: SBO:0000247
is: C00080
constant: false
initial amount: NaN
boundary condition: false
has only substance units: false
type: Species
notes: FORMULA: H CHARGE: 1 INCHI: "
is: CHEBI:24636
initial concentration: 1.0
name: proton
is: http://identifiers.org/pubchem.compound/3380

metaR CYSt4
type: Reaction
is: SBO:0000185
notes: GENE_ASSOCIATION: (11254.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11133652,PMID:12719981 NOTES:SAB
modifier: MODEL1310110063#
kinetic law: MODEL1310110063#
reversible: false
name: L-cysteine reversible transport via sodium symport
product: MODEL1310110063#
reactant: MODEL1310110063#
fast: false
is described by: ECO:0000304

http://identifiers.org/biomodels.db/MODEL1310110063#_6c537dfd_ddd1_4760_ab09_d3be1aa75a78
is: SBO:0000252
has only substance units: false
type: Species
is encoded by: hsa:6817
initial amount: NaN
constant: false
name: SULT1A1
boundary condition: true
initial concentration: NaN

metaR r1109
is: SBO:0000176
type: Reaction
fast: false
reversible: true
kinetic law: MODEL1310110063#
reactant: MODEL1310110063#
product: MODEL1310110063#
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 4.1.3.6 Confidence Level: 0 AUTHORS: PMID:11741334 NOTES:
name: Citrate oxaloacetate-lyase ((pro-3S)-CH2COO- -->acetate) Citrate cycle (TCA cycle) EC:4.1.3.6
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110063#_df38862e_5246_4b4b_b933_1322ee5fede3
boundary condition: true
type: Species
is: Q5JZF5
is encoded by: hsa:212
initial concentration: NaN
initial amount: NaN
constant: false
is: SBO:0000252
name: ALAS2
has only substance units: false

metaR ASNtN1
is: SBO:0000185
modifier: MODEL1310110063#
fast: false
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (92745.1) or (10991.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10823827,PMID:12845534 NOTES:SAB based om PMID 10823827
name: Asparagine transport (Na, H coupled)
reactant: MODEL1310110063#
product: MODEL1310110063#
type: Reaction
kinetic law: MODEL1310110063#
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110063#_b6007078_29f3_40ba_a28e_8b711ba5ff8c
type: Species
has only substance units: false
initial amount: NaN
is: SBO:0000297
initial concentration: NaN
is encoded by: hsa:9056
name: SLC3A1:SLC7A7
boundary condition: true
constant: false
has part: Q9UM01

http://identifiers.org/biomodels.db/MODEL1310110063#_95ed2d86_99c4_4793_b863_d26281e3ac61
is encoded by: hsa:7001
is: SBO:0000252
boundary condition: true
initial concentration: NaN
type: Species
constant: false
has only substance units: false
initial amount: NaN
name: PRDX2

metaM CE0785 m
initial concentration: 1.0
notes: FORMULA: C35H54N7O17P3S CHARGE: -4 INCHI: InChI=1/C35H58N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-26(44)63-19-18-37-25(43)16-17-38-33(47)30(46)35(2,3)21-56-62(53,54)59-61(51,52)55-20-24-29(58-60(48,49)50)28(45)34(57-24)42-23-41-27-31(36)39-22-40-32(27)42/h8-9,11-12,22-24,28-30,34,45-46H,4-7,10,13-21H2,1-3H3,(H,37,43)(H,38,47)(H,51,52)(H,53,54)(H2,36,39,40)(H2,48,49,50)/p-4/b9-8-,12-11-/t24-,28+,29+,30u,34-/m0/s1 EHMN_ABBREVIATION: CE0785
has only substance units: false
is: SBO:0000247
type: Species
boundary condition: false
initial amount: NaN
is: CHEBI:57795
constant: false
name: cis,cis-myristo-5,8-dienoyl-CoA

http://identifiers.org/biomodels.db/MODEL1310110063#_b493bd2e_70c6_42b7_b67c_ac942c958f85
name: NDUFS3
type: Species
constant: false
is: SBO:0000252
initial concentration: NaN
boundary condition: true
is encoded by: hsa:4722
initial amount: NaN
has only substance units: false
is: O75489

metaR PItg
is described by: ECO:0000000
reversible: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 2 AUTHORS: NOTES:NCD
is: SBO:0000185
fast: false
name: phosphate transport, Golgi apparatus
type: Reaction
product: MODEL1310110063#
kinetic law: MODEL1310110063#
reactant: MODEL1310110063#

metaM gmp c
notes: FORMULA: C10H12N5O8P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00141 EHMN_ABBREVIATION: C00144
initial amount: NaN
is: CHEBI:58115
is: HMDB01397
type: Species
constant: false
boundary condition: false
is: C00144
name: GMP
initial concentration: 1.0
is: SBO:0000247
has only substance units: false

metaM spc hs c
name: sphingosylphosphorylcholine
is: SBO:0000247
initial concentration: 1.0
type: Species
constant: false
notes: FORMULA: C23H50N2O5P CHARGE: 1 INCHI: InChI=1S/C23H49N2O5P/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-23(26)22(24)21-30-31(27,28)29-20-19-25(2,3)4/h17-18,22-23,26H,5-16,19-21,24H2,1-4H3/b18-17+/t22-,23+/m1/s1
boundary condition: false
initial amount: NaN
has only substance units: false
is: http://identifiers.org/pubchem.compound/5311445

http://identifiers.org/biomodels.db/MODEL1310110063#_147c27ff_174d_4fea_9b52_191e8bb5cb7c
has only substance units: false
type: Species
name: DHCR7
is: Q9UBM7
constant: false
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:1717
boundary condition: true
is: SBO:0000252

metaM ksii core4 g
is: CHEBI:17140
type: Species
constant: false
name: keratan sulfate II (core 4-linked)
initial amount: NaN
boundary condition: false
has only substance units: false
notes: FORMULA: C89H142N7O72S3X CHARGE: -4
is: HMDB01644
is: SBO:0000247
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110063#_227d233c_699f_4e0a_94f3_de3dc51427a9
initial amount: NaN
has only substance units: false
is: O43306
initial concentration: NaN
name: ADCY6
boundary condition: true
is: SBO:0000252
constant: false
type: Species
is encoded by: hsa:112

metaM HC02214 c
is: SBO:0000247
name: prostaglandin-f1alpha
is: CHEBI:28852
type: Species
notes: FORMULA: C20H35O5 CHARGE: -1 INCHI: InChI=1S/C20H36O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h12-13,15-19,21-23H,2-11,14H2,1H3,(H,24,25)/b13-12+/t15-,16+,17+,18-,19+/m0/s1
initial amount: NaN
constant: false
initial concentration: 1.0
has only substance units: false
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110063#_9d40d8ad_8de2_473c_89ba_8ece3e2ef9d4
is encoded by: hsa:5279
is encoded by: hsa:5277
has part: P57054
constant: false
has part: B2RAU6
is encoded by: hsa:9091
has only substance units: false
is: SBO:0000297
name: PIGP:PIGA:PIGC:PIGH:DPM2:PIGQ
boundary condition: true
initial amount: NaN
type: Species
is encoded by: hsa:51227
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110063#_f88b5caa_0290_4f51_a057_ef5c7c1d8857
boundary condition: true
type: Species
constant: false
is: SBO:0000252
has only substance units: false
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:9060
is: O95340
name: PAPSS2

metaR CYTK5n
product: MODEL1310110063#
type: Reaction
name: cytidylate kinase (CMP),nuclear
modifier: MODEL1310110063#
fast: false
reversible: true
reactant: MODEL1310110063#
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544 NOTES:
is: SBO:0000176
kinetic law: MODEL1310110063#
is version of: http://identifiers.org/ec-code/2.7.4.14
is described by: ECO:0000269

metaM hdcoa m
name: Hexadecenoyl-CoA (n-C16:1CoA)
constant: false
initial amount: NaN
is: HMDB06532
notes: FORMULA: C37H60N7O17P3S CHARGE: -4
has only substance units: false
initial concentration: 1.0
is: SBO:0000247
boundary condition: false
type: Species

metaR r1629
product: MODEL1310110063#
reactant: MODEL1310110063#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is described by: ECO:0000000
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
kinetic law: MODEL1310110063#
fast: false
is: SBO:0000185
reversible: true

metaM 3ttetddcoacrn e
name: 3-hydroxy trans5,8tetradecadienoyl carnitine
notes: FORMULA: C21H37NO5 CHARGE: 0
initial amount: NaN
is: SBO:0000247
initial concentration: 1.0
type: Species
is: HMDB02014
has only substance units: false
boundary condition: false
constant: false

metaM cyan c
is: HMDB02084
initial concentration: 1.0
is: CHEBI:18407
boundary condition: false
notes: FORMULA: CHN CHARGE: 0 INCHI: InChI=1S/CHN/c1-2/h1H EHMN_ABBREVIATION: C01326
type: Species
name: hydrogen cyanide
constant: false
has only substance units: false
initial amount: NaN
is: SBO:0000247

metaR EX lgnc LPAREN e RPAREN
kinetic law: MODEL1310110063#
reactant: MODEL1310110063#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: lignoceric acid exchange
type: Reaction

metaM h c
is: http://identifiers.org/pubchem.compound/3380
is: C00080
is: SBO:0000247
constant: false
has only substance units: false
initial amount: NaN
boundary condition: false
notes: FORMULA: H CHARGE: 1 INCHI: "
type: Species
name: proton
initial concentration: 1.0
is: CHEBI:24636

metaR C4STMO1r
kinetic law: MODEL1310110063#
is version of: http://identifiers.org/ec-code/1.14.13.72
fast: false
notes: GENE_ASSOCIATION: (6307.1) SUBSYSTEM: Cholesterol metabolism EC Number: Confidence Level: 4 AUTHORS: NOTES:EC 1.-.-.- NCD ER version NJ
modifier: MODEL1310110063#
is: SBO:0000176
reactant: MODEL1310110063#
product: MODEL1310110063#
is described by: ECO:0000000
name: C-4 sterol methyl oxidase (4,4-dimethylzymosterol)
reversible: false
type: Reaction

metaR r1628
reversible: true
kinetic law: MODEL1310110063#
reactant: MODEL1310110063#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
fast: false
is: SBO:0000185
product: MODEL1310110063#
is described by: ECO:0000000
type: Reaction

metaM glx c
notes: FORMULA: C2H1O3 CHARGE: -1 INCHI: InChI=1S/C2H2O3/c3-1-2(4)5/h1H,(H,4,5)/p-1 EHMN_ABBREVIATION: C00048
initial amount: NaN
boundary condition: false
type: Species
constant: false
is: SBO:0000247
has only substance units: false
is: HMDB00119
is: CHEBI:36655
name: glyoxylate
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110063#_182d19cc_c0be_41cd_b5ca_6f4a76065ac0
is: SBO:0000297
initial concentration: NaN
name: ATP5H:ATP5L:NSF:ATP5F1:ATP5G2:ATP5I:ATP5J:ATP5J2
is encoded by: hsa:517
has only substance units: false
constant: false
initial amount: NaN
type: Species
has part: Q06055
boundary condition: true

metaM CE5121 m
notes: FORMULA: C31H48N7O17P3S CHARGE: -4 INCHI: InChI=1/C31H52N7O17P3S/c1-4-5-6-7-8-9-10-11-22(40)59-15-14-33-21(39)12-13-34-29(43)26(42)31(2,3)17-52-58(49,50)55-57(47,48)51-16-20-25(54-56(44,45)46)24(41)30(53-20)38-19-37-23-27(32)35-18-36-28(23)38/h9-10,18-20,24-26,30,41-42H,4-8,11-17H2,1-3H3,(H,33,39)(H,34,43)(H,47,48)(H,49,50)(H2,32,35,36)(H2,44,45,46)/p-4/b10-9+/t20-,24+,25+,26u,30-/m0/s1 EHMN_ABBREVIATION: CE5121
name: trans-3-decenoyl-CoA
is: CHEBI:57449
initial amount: NaN
constant: false
is: SBO:0000247
type: Species
boundary condition: false
has only substance units: false
initial concentration: 1.0

metaM hs deg3 l
is: CHEBI:16126
name: heparan sulfate, degradation product 3
boundary condition: false
type: Species
has only substance units: false
notes: FORMULA: C81H117N5O97S10 CHARGE: -12
is: SBO:0000247
initial amount: NaN
constant: false
initial concentration: 1.0

metaR MANtly
is described by: ECO:0000000
name: mannose efflux from lysosome
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 2 AUTHORS: PMID:1751541,PMID:8993166 NOTES:NCD
reversible: false
kinetic law: MODEL1310110063#
type: Reaction
is: SBO:0000185
fast: false
reactant: MODEL1310110063#
product: MODEL1310110063#

metaM decdicrn e
has only substance units: false
is: HMDB13325
boundary condition: false
type: Species
name: decadienoyl carnitine
initial concentration: 1.0
constant: false
initial amount: NaN
is: SBO:0000247
notes: FORMULA: C17H29NO4 CHARGE: 0

metaR TTDCAtr
kinetic law: MODEL1310110063#
reversible: true
is: SBO:0000185
name: tetradecanoate (transport)
product: MODEL1310110063#
reactant: MODEL1310110063#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10811962,PMID:11161786 NOTES:
fast: false
is described by: ECO:0000269

metaM succ x
boundary condition: false
is: CHEBI:30031
is: HMDB00254
initial amount: NaN
is: C00042
notes: FORMULA: C4H4O4 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00049 EHMN_ABBREVIATION: C00042
is: SBO:0000247
initial concentration: 1.0
constant: false
name: Succinate
has only substance units: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110063#_c49e92cd_01b6_4dc8_8ca1_e212a25a90c7
constant: false
name: SGPL1
boundary condition: true
is encoded by: hsa:8879
initial concentration: NaN
is: O95470
has only substance units: false
initial amount: NaN
type: Species
is: SBO:0000252

metaR NACHEX16ly
modifier: MODEL1310110063#
notes: GENE_ASSOCIATION: (3073.1 and 3074.1) or (3074.1) or (3073.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.52 Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12706724,PMID:8993162 NOTES:NCD
is version of: http://identifiers.org/ec-code/3.2.1.52
is described by: ECO:0000000
name: beta-N-acetylhexosaminidase, lysosomal
product: MODEL1310110063#
reactant: MODEL1310110063#
type: Reaction
reversible: false
is: SBO:0000176
kinetic law: MODEL1310110063#
fast: false

metaR r1627
kinetic law: MODEL1310110063#
reactant: MODEL1310110063#
is described by: ECO:0000000
type: Reaction
reversible: true
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
fast: false
is: SBO:0000185
product: MODEL1310110063#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:

metaR r0545
reactant: MODEL1310110063#
is version of: http://identifiers.org/ec-code/3.6.1.5
name: Phenylacetaldehyde:NAD+ oxidoreductase Phenylalanine metabolism / Styrene degradation EC:1.2.1.5 EC:1.2.1.39
fast: false
is: SBO:0000176
type: Reaction
modifier: MODEL1310110063#
notes: GENE_ASSOCIATION: (AV717590.1) or (953.1) or (956.1) or (377841.1) SUBSYSTEM: Phenylalanine metabolism EC Number: 1.2.1.5 Confidence Level: 0 AUTHORS: PMID:15230339 NOTES:
is described by: ECO:0000000
kinetic law: MODEL1310110063#
reversible: true
product: MODEL1310110063#

metaR RETFA
reversible: false
is: SBO:0000176
kinetic law: MODEL1310110063#
name: retinol acyltransferase
reactant: MODEL1310110063#
fast: false
product: MODEL1310110063#
notes: GENE_ASSOCIATION: SUBSYSTEM: Vitamin A metabolism EC Number: 2.3.1.76 Confidence Level: 2 AUTHORS: PMID:1503811 NOTES:IT
type: Reaction
is described by: ECO:0000000

metaM ksi deg24 l
notes: FORMULA: C118H191N8O101S5 CHARGE: -5
constant: false
type: Species
is: SBO:0000247
boundary condition: false
is: HMDB00143
is: CHEBI:12936
has only substance units: false
initial concentration: 1.0
initial amount: NaN
name: keratan sulfate I, degradation product 24

http://identifiers.org/biomodels.db/MODEL1310110063#_59026d4d_27e7_4e96_a8de_97a18a8be038
constant: false
is: Q5JWV8
has only substance units: false
name: ACSL4
type: Species
is: SBO:0000252
is encoded by: hsa:2182
initial amount: NaN
initial concentration: NaN
boundary condition: true

metaR r1401
reactant: MODEL1310110063#
is version of: http://identifiers.org/ec-code/2.3.1.51
is version of: http://identifiers.org/ec-code/2.7.10.1
is described by: ECO:0000000
product: MODEL1310110063#
is version of: http://identifiers.org/ec-code/3.1.1.3
is: SBO:0000185
modifier: MODEL1310110063#
kinetic law: MODEL1310110063#
type: Reaction
reversible: false
notes: GENE_ASSOCIATION: (AA177072.1) or (AA203143.1) or (56894.1) or (56895.1) or (AGPAT7.1) or (AI818585.1) or (AI971023.1) or (1956.1) or (54898.1) or (60481.1) or (79071.1) or (114799.1) or (157570.1) or (8372.1) or (LOC647190.1) or (9926.1) or (129642.1) or (MBOAT5.1) or (79143.1) or (N63787.1) or (54995.1) or (80339.1) or (9197.1) or (6901.1) or (W87865.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:6361812,PMID:8132483 NOTES:
is version of: http://identifiers.org/ec-code/3.2.1.35
is version of: http://identifiers.org/ec-code/2.3.1.41
fast: false
name: Facilitated diffusion

metaR M13N2Tg
notes: GENE_ASSOCIATION: (4245.1) SUBSYSTEM: N-glycan synthesis EC Number: 2.4.1.101 Confidence Level: 0 AUTHORS: PMID:12621063 NOTES:NCD
is described by: ECO:0000000
is: SBO:0000176
reactant: MODEL1310110063#
type: Reaction
product: MODEL1310110063#
kinetic law: MODEL1310110063#
modifier: MODEL1310110063#
reversible: false
fast: false
name: alpha-1,3-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase
is version of: http://identifiers.org/ec-code/2.4.1.101

http://identifiers.org/biomodels.db/MODEL1310110063#_61e489da_c7f7_4a4f_8b6e_1cf98d62f261
is: SBO:0000252
type: Species
initial concentration: NaN
is: P05091
name: ALDH2
constant: false
has only substance units: false
initial amount: NaN
boundary condition: true
is encoded by: hsa:217

metaR LEUKTRA4t
name: leukotriene A4 transport
kinetic law: MODEL1310110063#
reversible: true
reactant: MODEL1310110063#
type: Reaction
product: MODEL1310110063#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: 1.1.1.27 Confidence Level: 2 AUTHORS: PMID:15987839,PMID:9927705 NOTES:
is described by: ECO:0000269
fast: false
is: SBO:0000185

metaR BILIRED
kinetic law: MODEL1310110063#
product: MODEL1310110063#
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/1.3.1.24
type: Reaction
name: Nad(p)h biliverdin reductase
reactant: MODEL1310110063#
modifier: MODEL1310110063#
notes: GENE_ASSOCIATION: (645.1) or (644.1) SUBSYSTEM: Heme degradation EC Number: 1.3.1.24 Confidence Level: 0 AUTHORS: PMID:12456881,PMID:7656592,PMID:8117274 NOTES:TDV
is: SBO:0000176
reversible: false
fast: false

http://identifiers.org/biomodels.db/MODEL1310110063#_95e5ceec_0f72_4d14_adbc_096f5a317bb9
initial amount: NaN
is encoded by: hsa:1103
has only substance units: false
initial concentration: NaN
type: Species
constant: false
name: CHAT
is: SBO:0000252
boundary condition: true
is: Q6LEN5

http://identifiers.org/biomodels.db/MODEL1310110063#_c8ed483d_7e3c_49a5_bcf3_00769021cfc2
initial amount: NaN
is: SBO:0000252
name: PIGL
is encoded by: hsa:9487
initial concentration: NaN
is: Q9Y2B2
type: Species
has only substance units: false
boundary condition: true
constant: false

metaR TAURtcx
name: taurine transport (sodium symport) (cytosol to peroxisome)
product: MODEL1310110063#
reversible: true
is: SBO:0000185
kinetic law: MODEL1310110063#
modifier: MODEL1310110063#
notes: GENE_ASSOCIATION: (6533.1) SUBSYSTEM: Taurine and hypotaurine metabolism EC Number: Confidence Level: 1 AUTHORS: PMID:8010975 NOTES:SAB
type: Reaction
reactant: MODEL1310110063#
fast: false
is described by: ECO:0000212

metaR H2Otly
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD
name: H2O transport, lysosomal
product: MODEL1310110063#
type: Reaction
kinetic law: MODEL1310110063#
fast: false
is described by: ECO:0000000
is: SBO:0000185
reversible: true
reactant: MODEL1310110063#

http://identifiers.org/biomodels.db/MODEL1310110063#_bb26341b_008c_4d10_bba8_79a01daaacd6
name: DGKI
is: SBO:0000252
constant: false
initial amount: NaN
has only substance units: false
boundary condition: true
is: O75912
type: Species
is encoded by: hsa:9162
initial concentration: NaN

metaR r1626
is: SBO:0000185
is described by: ECO:0000000
type: Reaction
kinetic law: MODEL1310110063#
reactant: MODEL1310110063#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
modifier: MODEL1310110063#
fast: false
notes: GENE_ASSOCIATION: (19.1) or (AL038231.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
product: MODEL1310110063#
reversible: true

metaM ksi pre13 g
is: HMDB00175
type: Species
is: SBO:0000247
is: C00130
constant: false
initial concentration: 1.0
has only substance units: false
boundary condition: false
notes: FORMULA: C143H231N10O111S3X CHARGE: -4
is: CHEBI:58053
name: keratan sulfate I biosynthesis, precursor 13
initial amount: NaN

metaR FERO
type: Reaction
is: SBO:0000176
is described by: ECO:0000134
modifier: MODEL1310110063#
kinetic law: MODEL1310110063#
notes: GENE_ASSOCIATION: (9843.1) SUBSYSTEM: Vitamin B2 metabolism EC Number: Confidence Level: 4 AUTHORS: Sareen S. Gropper, Jack L. Smith, James L. Groff (2009) Advanced nutrition and human metabolism, Wadsworth cengage learning, 5th edition, page 472-476. NOTES:
reactant: MODEL1310110063#
fast: false
product: MODEL1310110063#
reversible: false
name: ferroxidase

metaR r1400
reversible: false
is described by: ECO:0000000
type: Reaction
name: Active transport
reactant: MODEL1310110063#
kinetic law: MODEL1310110063#
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 0 AUTHORS: PMID:12133002,PMID:4475632,PMID:5810070 NOTES:
fast: false
is: SBO:0000185
product: MODEL1310110063#

metaM bhb e
name: (R)-3-hydroxybutyrate
type: Species
is: SBO:0000247
has only substance units: false
is: HMDB00011
initial amount: NaN
notes: FORMULA: C4H7O3 CHARGE: -1 INCHI: InChI=1S/C4H8O3/c1-3(5)2-4(6)7/h3,5H,2H2,1H3,(H,6,7)/p-1/t3-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00661 EHMN_ABBREVIATION: C01089
boundary condition: false
initial concentration: 1.0
is: CHEBI:10983
constant: false

http://identifiers.org/biomodels.db/MODEL1310110063#_67c38850_c733_4458_9f7c_9339c4828bc3
constant: false
initial amount: NaN
boundary condition: true
is encoded by: hsa:6822
initial concentration: NaN
is: SBO:0000252
is: Q06520
name: SULT2A1
type: Species
has only substance units: false

metaM h n
has only substance units: false
boundary condition: false
is: SBO:0000247
initial amount: NaN
name: proton
constant: false
is: CHEBI:24636
type: Species
initial concentration: 1.0
notes: FORMULA: H CHARGE: 1 INCHI: InChI=1S/p+1/i/hH HEPATONET_1.0_ABBREVIATION: HC00083 EHMN_ABBREVIATION: C00080

http://identifiers.org/biomodels.db/MODEL1310110063#_a479e60a_b86f_43ca_90f3_e8a55eefdefb
has only substance units: false
initial amount: NaN
is encoded by: hsa:8818
type: Species
initial concentration: NaN
has part: Q86TM7
constant: false
boundary condition: true
has part: O94777
is encoded by: hsa:8813
is: SBO:0000297
name: DPM3:DPM1:DPM2
has part: O60762
is encoded by: hsa:54344

metaM man1p c
initial amount: NaN
name: D-Mannose 1-phosphate
initial concentration: 1.0
notes: FORMULA: C6H11O9P CHARGE: -2 INCHI: InChI=1S/C6H13O9P/c7-1-2-3(8)4(9)5(10)6(14-2)15-16(11,12)13/h2-10H,1H2,(H2,11,12,13)/t2-,3-,4+,5+,6?/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00466 EHMN_ABBREVIATION: C00636
has only substance units: false
boundary condition: false
is: CHEBI:35374
is: HMDB06330
is: SBO:0000247
constant: false
type: Species

metaR EX 4nphsf LPAREN e RPAREN
kinetic law: MODEL1310110063#
reactant: MODEL1310110063#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 4-Nitrophenyl sulfate exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110063#_7864b790_1a12_4756_9e39_afeb14331571
boundary condition: true
is encoded by: hsa:80025
type: Species
is: SBO:0000252
initial concentration: NaN
constant: false
initial amount: NaN
has only substance units: false
name: PANK2

http://identifiers.org/biomodels.db/MODEL1310110063#_e0d6c7e2_70de_4535_a91e_c2aecc7edb49
has only substance units: false
type: Species
initial concentration: NaN
constant: false
boundary condition: true
is encoded by: hsa:22305
initial amount: NaN
is: SBO:0000252
name: _22305_2_c

metaR r0474
fast: false
product: MODEL1310110063#
reactant: MODEL1310110063#
type: Reaction
kinetic law: MODEL1310110063#
is: SBO:0000176
name: 2-Deoxyadenosine 5-diphosphate:oxidized-thioredoxin 2-oxidoreductase Purine metabolism EC:1.17.4.1
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Nucleotide interconversion EC Number: 1.17.4.1 Confidence Level: 0 AUTHORS: PMID:6121703,PMID:8074691 NOTES:
reversible: true

metaR r0321
notes: GENE_ASSOCIATION: (AA664770.1) or (AI684467.1) or (8833.1) SUBSYSTEM: Cholesterol metabolism EC Number: 6.2.1.16 Confidence Level: 0 AUTHORS: PMID:4073493 NOTES:
kinetic law: MODEL1310110063#
is: SBO:0000176
type: Reaction
product: MODEL1310110063#
is described by: ECO:0000000
fast: false
is version of: http://identifiers.org/ec-code/6.3.5.2
reversible: false
reactant: MODEL1310110063#
name: Acetoacetate:CoA ligase (AMP-forming) Butanoate metabolism EC:6.2.1.16
modifier: MODEL1310110063#

metaR ACACT1r
fast: false
product: MODEL1310110063#
notes: GENE_ASSOCIATION: (39.1) SUBSYSTEM: Tryptophan metabolism EC Number: 2.3.1.9 Confidence Level: 0 AUTHORS: NOTES:JLR- reversible form of ACACT1
type: Reaction
modifier: MODEL1310110063#
is described by: ECO:0000000
name: acetyl-CoA C-acetyltransferase
is version of: http://identifiers.org/ec-code/2.3.1.9
reactant: MODEL1310110063#
kinetic law: MODEL1310110063#
reversible: true
is: SBO:0000176

metaR r1625
reversible: true
reactant: MODEL1310110063#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is described by: ECO:0000000
type: Reaction
fast: false
notes: GENE_ASSOCIATION: (19.1) or (AL038231.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
product: MODEL1310110063#
is: SBO:0000185
modifier: MODEL1310110063#
kinetic law: MODEL1310110063#

metaR EX 3ttetddcoacrn
kinetic law: MODEL1310110063#
reactant: MODEL1310110063#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for 3-hydroxy trans5,8tetradecadienoyl carnitine
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110063#_f1f97fd6_3de9_4e8e_a38a_a819fbf6e3f3
is encoded by: hsa:33
initial concentration: NaN
name: ACADL
has only substance units: false
boundary condition: true
initial amount: NaN
constant: false
is: SBO:0000252
is: P28330
type: Species

http://identifiers.org/biomodels.db/MODEL1310110063#_b316ce6c_f382_4f83_b866_791f55d839d9
constant: false
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:2747
boundary condition: true
has only substance units: false
name: GLUD2
type: Species
initial amount: NaN
is: P49448

metaM 2octpencoa m
is: SBO:0000247
initial concentration: 1.0
boundary condition: false
has only substance units: false
notes: FORMULA: C39H56N7O17P3S CHARGE: -4
initial amount: NaN
type: Species
name: 2,6,9,12,15-octadecapentenoylcoa
is: http://identifiers.org/pubchem.compound/5280355
constant: false

http://identifiers.org/biomodels.db/MODEL1310110063#_7ee8a798_ad54_491e_a9e7_55733f919277
type: Species
initial concentration: NaN
has only substance units: false
name: SLC6A7
is: SBO:0000252
constant: false
is encoded by: hsa:6534
initial amount: NaN
boundary condition: true
is: Q99884

http://identifiers.org/biomodels.db/MODEL1310110063#_4c6f2f9a_e943_4740_b2be_a6f59534f020
has only substance units: false
constant: false
name: COX5B
initial concentration: NaN
boundary condition: true
is encoded by: hsa:1329
type: Species
initial amount: NaN
is: Q53YB7
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110063#_44b71267_ccd1_4ebc_b7c7_f25aeda84672
is: SBO:0000252
boundary condition: true
is encoded by: hsa:6718
is: P51857
initial amount: NaN
name: AKR1D1
constant: false
type: Species
has only substance units: false
initial concentration: NaN

metaM dlnlcgcoa r
initial concentration: 1.0
is: C03595
initial amount: NaN
name: dihomo-gamma-linolenyl coenzyme A
constant: false
has only substance units: false
is: CHEBI:27979
boundary condition: false
notes: FORMULA: C41H64N7O17P3S CHARGE: -4 INCHI: InChI=1S/C41H68N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-32(50)69-25-24-43-31(49)22-23-44-39(53)36(52)41(2,3)27-62-68(59,60)65-67(57,58)61-26-30-35(64-66(54,55)56)34(51)40(63-30)48-29-47-33-37(42)45-28-46-38(33)48/h8-9,11-12,14-15,28-30,34-36,40,51-52H,4-7,10,13,16-27H2,1-3H3,(H,43,49)(H,44,53)(H,57,58)(H,59,60)(H2,42,45,46)(H2,54,55,56)/b9-8-,12-11-,15-14-/t30-,34-,35-,36+,40-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC02102
type: Species
is: SBO:0000247

metaR OCDCAtr
reactant: MODEL1310110063#
product: MODEL1310110063#
kinetic law: MODEL1310110063#
is described by: ECO:0000000
reversible: true
name: fatty acid transport via diffusion
fast: false
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11788354,PMID:12864740 NOTES:NJ
is: SBO:0000185

metaM pep c
initial amount: NaN
constant: false
notes: FORMULA: C3H2O6P CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00076 EHMN_ABBREVIATION: C00074
is: C00074
initial concentration: 1.0
has only substance units: false
is: HMDB00263
type: Species
name: Phosphoenolpyruvate
is: SBO:0000247
is: CHEBI:18021
boundary condition: false

metaM m8masn r
is: SBO:0000247
initial amount: NaN
has only substance units: false
type: Species
is: C05876
name: (alpha-D-mannosyl)8-beta-D-mannosyl-diacetylchitobiosyl-L-asparagine (protein)
constant: false
notes: FORMULA: C70H117N2O55X CHARGE: 0
boundary condition: false
initial concentration: 1.0

metaM 3octdectecoa m
initial concentration: 1.0
name: 3,6,9,12-octadecatetraenoylcoa
initial amount: NaN
boundary condition: false
type: Species
constant: false
is: http://identifiers.org/pubchem.compound/5280355
is: SBO:0000247
has only substance units: false
notes: FORMULA: C39H58N7O17P3S CHARGE: -4

metaM ump r
constant: false
notes: FORMULA: C9H11N2O9P CHARGE: -2 INCHI: InChI=1S/C9H13N2O9P/c12-5-1-2-11(9(15)10-5)8-7(14)6(13)4(20-8)3-19-21(16,17)18/h1-2,4,6-8,13-14H,3H2,(H,10,12,15)(H2,16,17,18)/p-2/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00105 EHMN_ABBREVIATION: C00105
initial amount: NaN
is: HMDB00288
name: UMP
boundary condition: false
type: Species
has only substance units: false
initial concentration: 1.0
is: SBO:0000247
is: CHEBI:57865

metaM h l
initial amount: NaN
constant: false
notes: FORMULA: H CHARGE: 1 INCHI: "
initial concentration: 1.0
is: CHEBI:24636
has only substance units: false
boundary condition: false
name: proton
is: SBO:0000247
type: Species
is: C00080
is: http://identifiers.org/pubchem.compound/3380

metaR r0245
notes: GENE_ASSOCIATION: (1719.1) or (HG2846-HT2983.1) SUBSYSTEM: Glycerophospholipid metabolism EC Number: 1.1.1.72 Confidence Level: 0 AUTHORS: PMID:11716357,PMID:6753936,PMID:6815419,PMID:8916913,PMID:9693960 NOTES:
reversible: true
reactant: MODEL1310110063#
product: MODEL1310110063#
type: Reaction
is version of: http://identifiers.org/ec-code/1.5.1.3
kinetic law: MODEL1310110063#
fast: false
name: Glycerol:NADP+ oxidoreductase Glycerolipid metabolism EC:1.1.1.2 EC:1.1.1.72
modifier: MODEL1310110063#
is: SBO:0000176
is described by: ECO:0000000

metaR r1624
product: MODEL1310110063#
is described by: ECO:0000000
type: Reaction
modifier: MODEL1310110063#
kinetic law: MODEL1310110063#
fast: false
reversible: true
is: SBO:0000185
reactant: MODEL1310110063#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
notes: GENE_ASSOCIATION: (19.1) or (AL038231.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:

metaR CSNATer
is version of: http://identifiers.org/ec-code/2.3.1.7
product: MODEL1310110063#
modifier: MODEL1310110063#
reversible: true
kinetic law: MODEL1310110063#
is described by: ECO:0000254
name: carnitine O-acetyltransferase, endolasmic reticulum
is: SBO:0000176
type: Reaction
notes: GENE_ASSOCIATION: (1384.3) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.7 Confidence Level: 2 AUTHORS: PMID:11257506,PMID:3759988 NOTES:mm
reactant: MODEL1310110063#
fast: false

http://identifiers.org/biomodels.db/MODEL1310110063#_9891e373_a382_48e0_8a8e_aec429ab3f2f
constant: false
boundary condition: true
name: ACSS2
is: SBO:0000252
initial amount: NaN
type: Species
has only substance units: false
initial concentration: NaN
is encoded by: hsa:55902
is: Q5QPH3

metaR ME1m
notes: GENE_ASSOCIATION: (4200.1) SUBSYSTEM: Pyruvate metabolism EC Number: 1.1.1.40 Confidence Level: 0 AUTHORS: NOTES:NCD
is: SBO:0000176
reversible: false
fast: false
reactant: MODEL1310110063#
name: malic enzyme (NAD), mitochondrial
is version of: http://identifiers.org/ec-code/1.1.1.38
product: MODEL1310110063#
type: Reaction
modifier: MODEL1310110063#
kinetic law: MODEL1310110063#
is described by: ECO:0000000

metaM thf m
has only substance units: false
initial amount: NaN
constant: false
is: SBO:0000247
name: 5,6,7,8-Tetrahydrofolate
is: CHEBI:57453
notes: FORMULA: C19H21N7O6 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00102 EHMN_ABBREVIATION: C00101
type: Species
is: C00101
initial concentration: 1.0
is: HMDB01846
boundary condition: false

metaM adrn c
is: HMDB02226
boundary condition: false
initial amount: NaN
is: CHEBI:53487
is: SBO:0000247
name: adrenic acid
type: Species
initial concentration: 1.0
notes: FORMULA: C22H35O2 CHARGE: -1 INCHI: InChI=1S/C22H36O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22(23)24/h6-7,9-10,12-13,15-16H,2-5,8,11,14,17-21H2,1H3,(H,23,24)/b7-6-,10-9-,13-12-,16-15-
constant: false
has only substance units: false

metaR GALASE1ly
is described by: ECO:0000000
reversible: false
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.2.1.18
fast: false
modifier: MODEL1310110063#
is version of: http://identifiers.org/ec-code/3.2.1.23
product: MODEL1310110063#
name: beta-galactosidase, lysosomal
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) or (5476.1) and (2720.1) SUBSYSTEM: N-glycan degradation EC Number: 3.2.1.23 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD
type: Reaction
reactant: MODEL1310110063#
is version of: http://identifiers.org/ec-code/3.1.6.4
is version of: http://identifiers.org/ec-code/3.4.16.5
kinetic law: MODEL1310110063#

http://identifiers.org/biomodels.db/MODEL1310110063#_1f2e8191_6bd3_47af_af9c_344a6dda0b2f
is: SBO:0000252
is: P05187
boundary condition: true
initial concentration: NaN
type: Species
name: ALPP
initial amount: NaN
has only substance units: false
constant: false
is encoded by: hsa:250

metaM h m
is: CHEBI:24636
has only substance units: false
is: http://identifiers.org/pubchem.compound/3380
name: proton
is: SBO:0000247
type: Species
initial concentration: 1.0
boundary condition: false
initial amount: NaN
is: C00080
constant: false
notes: FORMULA: H CHARGE: 1 INCHI: " HEPATONET_1.0_ABBREVIATION: HC00083 EHMN_ABBREVIATION: C00080

http://identifiers.org/biomodels.db/MODEL1310110063#_ec6b20c2_66bc_4d9e_8195_644d943cb6f4
type: Species
initial amount: NaN
is encoded by: hsa:2585
has only substance units: false
is: Q01415
initial concentration: NaN
boundary condition: true
constant: false
is: SBO:0000252
name: GALK2

metaR r1623
kinetic law: MODEL1310110063#
fast: false
is: SBO:0000185
reactant: MODEL1310110063#
is described by: ECO:0000000
type: Reaction
modifier: MODEL1310110063#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reversible: true
notes: GENE_ASSOCIATION: (19.1) or (AL038231.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
product: MODEL1310110063#

http://identifiers.org/biomodels.db/MODEL1310110063#_533c17af_a709_4242_9a66_1a9ce64a4cee
is encoded by: hsa:2731
has only substance units: false
constant: false
initial concentration: NaN
boundary condition: true
initial amount: NaN
name: GLDC
type: Species
is: SBO:0000252
is: P23378

metaR r0246
reversible: false
is version of: http://identifiers.org/ec-code/1.5.1.3
name: Glycerol:NADP+ oxidoreductase Glycerolipid metabolism EC:1.1.1.72 EC:1.1.1.2
kinetic law: MODEL1310110063#
type: Reaction
fast: false
modifier: MODEL1310110063#
product: MODEL1310110063#
notes: GENE_ASSOCIATION: (1719.1) or (HG2846-HT2983.1) SUBSYSTEM: Unassigned EC Number: 1.1.1.72 Confidence Level: 0 AUTHORS: PMID:11716357,PMID:6753936,PMID:6815419,PMID:8916913,PMID:9693960 NOTES:
reactant: MODEL1310110063#
is: SBO:0000176
is described by: ECO:0000000

metaM 2dpmhobq m
initial concentration: 1.0
boundary condition: false
type: Species
has only substance units: false
initial amount: NaN
is: CHEBI:50771
constant: false
notes: FORMULA: C58H88O4 CHARGE: 0 INCHI: InChI=1S/C58H88O4/c1-43(2)23-14-24-44(3)25-15-26-45(4)27-16-28-46(5)29-17-30-47(6)31-18-32-48(7)33-19-34-49(8)35-20-36-50(9)37-21-38-51(10)39-22-40-52(11)41-42-54-53(12)55(59)57(61)58(62-13)56(54)60/h23,25,27,29,31,33,35,37,39,41,61H,14-22,24,26,28,30,32,34,36,38,40,42H2,1-13H3/b44-25+,45-27+,46-29+,47-31+,48-33+,49-35+,50-37+,51-39+,52-41+
is: HMDB06484
is: SBO:0000247
name: 2-decaprenyl-5-hydroxy-6-methoxy-3-methyl-1,4-benzoquinone

metaM paps c
has only substance units: false
is: CHEBI:58339
type: Species
is: HMDB01134
notes: FORMULA: C10H11N5O13P2S CHARGE: -4 INCHI: InChI=1S/C10H15N5O13P2S/c11-8-5-9(13-2-12-8)15(3-14-5)10-6(16)7(27-29(17,18)19)4(26-10)1-25-30(20,21)28-31(22,23)24/h2-4,6-7,10,16H,1H2,(H,20,21)(H2,11,12,13)(H2,17,18,19)(H,22,23,24)/p-4/t4-,6-,7-,10-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00058 EHMN_ABBREVIATION: C00053
is: SBO:0000247
initial concentration: 1.0
constant: false
initial amount: NaN
boundary condition: false
name: (2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-4-hydroxy-2-({[(sulfonatooxy)phosphinato]oxy}methyl)oxolan-3-yl phosphate

metaR r0549
kinetic law: MODEL1310110063#
is version of: http://identifiers.org/ec-code/1.6.99.3
is version of: http://identifiers.org/ec-code/6.1.1.17
name: 4-aminobutanal:NAD+ 1-oxidoreductase; 4-aminobutyraldehyde:NAD+ oxidoreductase Urea cycle and metabolism of amino groups / beta-Alanine metabolism EC:1.2.1.3 EC:1.2.1.19
modifier: MODEL1310110063#
is: SBO:0000176
type: Reaction
is version of: http://identifiers.org/ec-code/1.6.5.3
reversible: true
notes: GENE_ASSOCIATION: (AA629629.1) or (AA854479.1) or (AI345944.1) or (AI378339.1) or (AI601100.1) or (AI631997.1) or (AI935189.1) or (124454.1) or (F23536.1) or (FLJ44968.1) or (H45672.1) or (H53099.1) or (3550.1) or (LOC727762.1) or (4694.1) or (4705.1) or (126328.1) or (55967.1) or (51079.1) or (4695.1) or (4696.1) or (4697.1) or (56901.1) or (4698.1) or (4700.1) or (4701.1) or (4702.1) or (4704.1) or (4706.1) or (4707.1) or (4716.1) or (54539.1) or (4708.1) or (4709.1) or (4710.1) or (4711.1) or (4712.1) or (4713.1) or (4714.1) or (4715.1) or (4717.1) or (4718.1) or (4719.1) or (4720.1) or (4722.1) or (4724.1) or (4725.1) or (4726.1) or (374291.1) or (4728.1) or (4723.1) or (4729.1) or (4731.1) SUBSYSTEM: Glutamate metabolism EC Number: 1.2.1.3 Confidence Level: 0 AUTHORS: PMID:2925663,PMID:8155713,PMID:8269919,PMID:8786138,PMID:9417993 NOTES:
is described by: ECO:0000000
fast: false
product: MODEL1310110063#
reactant: MODEL1310110063#

metaR EX cmp LPAREN e RPAREN
kinetic law: MODEL1310110063#
reactant: MODEL1310110063#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: CMP exchange
type: Reaction

metaR EX co2 LPAREN e RPAREN
kinetic law: MODEL1310110063#
reactant: MODEL1310110063#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: CO2 exchange
type: Reaction

metaM gtp e
initial amount: NaN
initial concentration: 1.0
constant: false
is: CHEBI:37565
notes: FORMULA: C10H12N5O14P3 CHARGE: -4 INCHI: InChI=1S/C10H16N5O14P3/c11-10-13-7-4(8(18)14-10)12-2-15(7)9-6(17)5(16)3(27-9)1-26-31(22,23)29-32(24,25)28-30(19,20)21/h2-3,5-6,9,16-17H,1H2,(H,22,23)(H,24,25)(H2,19,20,21)(H3,11,13,14,18)/p-4/t3-,5-,6-,9-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00051 EHMN_ABBREVIATION: C00044
boundary condition: false
is: SBO:0000247
type: Species
has only substance units: false
is: HMDB01273
name: GTP(4-)

http://identifiers.org/biomodels.db/MODEL1310110063#_281eb905_a066_4201_bf19_3edca9b27948
type: Species
is encoded by: hsa:249
initial concentration: NaN
boundary condition: true
is: SBO:0000252
is: B7Z4Y6
initial amount: NaN
name: ALPL
constant: false
has only substance units: false

metaM bhb m
is: SBO:0000247
is: HMDB00011
is: CHEBI:10983
has only substance units: false
constant: false
name: (R)-3-hydroxybutyrate
notes: FORMULA: C4H7O3 CHARGE: -1 INCHI: InChI=1S/C4H8O3/c1-3(5)2-4(6)7/h3,5H,2H2,1H3,(H,6,7)/p-1/t3-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00661 EHMN_ABBREVIATION: C01089
initial amount: NaN
boundary condition: false
type: Species
initial concentration: 1.0

metaM doldp U r
constant: false
is: SBO:0000247
is: CHEBI:15750
boundary condition: false
initial concentration: 1.0
type: Species
has only substance units: false
name: Dolichol diphosphate, human uterine homolog
initial amount: NaN
notes: FORMULA: C1025H1670O70P20 CHARGE: -30 INCHI: InChI=1S/C25H46O7P2/c1-21(2)11-7-12-22(3)13-8-14-23(4)15-9-16-24(5)17-10-18-25(6)19-20-31-34(29,30)32-33(26,27)28/h11,13,15,17,25H,7-10,12,14,16,18-20H2,1-6H3,(H,29,30)(H2,26,27,28)/b22-13+,23-15+,24-17-

metaR r1622
product: MODEL1310110063#
kinetic law: MODEL1310110063#
is described by: ECO:0000000
type: Reaction
reversible: true
fast: false
is: SBO:0000185
reactant: MODEL1310110063#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
notes: GENE_ASSOCIATION: (19.1) or (AL038231.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
modifier: MODEL1310110063#

metaR ASNNm
kinetic law: MODEL1310110063#
is version of: http://identifiers.org/ec-code/3.5.1.1
is described by: ECO:0000254
product: MODEL1310110063#
reversible: false
is: SBO:0000176
reactant: MODEL1310110063#
name: L-asparaginase (mitochondrial)
fast: false
modifier: MODEL1310110063#
type: Reaction
notes: GENE_ASSOCIATION: (80150.1) SUBSYSTEM: Alanine and aspartate metabolism EC Number: 3.5.1.1 Confidence Level: 2 AUTHORS: PMID:11984834 NOTES:PMID: 11984834 (denotes it as potentially mitochondrial) mm

http://identifiers.org/biomodels.db/MODEL1310110063#_1b4c6a14_f859_44e9_96e1_ec59a5506e57
initial amount: NaN
constant: false
name: ATP5D
is encoded by: hsa:513
is: P30049
is: SBO:0000252
type: Species
has only substance units: false
boundary condition: true
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110063#_a33e9501_447d_4e70_9f5d_a0ab67e734c0
initial amount: NaN
is encoded by: hsa:4707
name: NDUFB1
boundary condition: true
has only substance units: false
is: O75438
type: Species
initial concentration: NaN
is: SBO:0000252
constant: false

http://identifiers.org/biomodels.db/MODEL1310110063#_eac6f696_c054_430d_a8b1_385ba0c260cd
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:AGPAT7
has only substance units: false
name: _AGPAT7_1_c
boundary condition: true
initial concentration: NaN
constant: false
type: Species

metaR CSNAT3x
name: carnitine O-aceyltransferase, peroxisomal
kinetic law: MODEL1310110063#
notes: GENE_ASSOCIATION: (1384.2) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.7 Confidence Level: 4 AUTHORS: PMID:7654220,PMID:7829107 NOTES:NJ
fast: false
type: Reaction
modifier: MODEL1310110063#
is described by: ECO:0000269
reactant: MODEL1310110063#
product: MODEL1310110063#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.3.1.7
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110063#_23618734_1b36_477b_9c6f_6dbc1fa75f8b
constant: false
name: SULT1A3
has only substance units: false
boundary condition: true
is encoded by: hsa:6818
initial amount: NaN
is: SBO:0000252
is: Q1ET61
initial concentration: NaN
type: Species

http://identifiers.org/biomodels.db/MODEL1310110063#_479a7fad_5162_4939_ae50_0550f9623add
initial concentration: NaN
boundary condition: true
is: Q86VV3
constant: false
has only substance units: false
is: SBO:0000252
initial amount: NaN
type: Species
is encoded by: hsa:953
name: ENTPD1

metaR AG13T10g
is: SBO:0000176
notes: GENE_ASSOCIATION: (79369.1) or (10678.1) or (11041.1) or (146712.1) or (374907.1) or (93010.1) or (374907.2) or (10331.1) or (10678.2) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.149 Confidence Level: 4 AUTHORS: PMID:10747980,PMID:11042166,PMID:12061784,PMID:12512857,PMID:15560372,PMID:15620693,PMID:9405606 NOTES:NCD
fast: false
reactant: MODEL1310110063#
name: N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase, Golgi apparatus
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/2.4.1.149
type: Reaction
modifier: MODEL1310110063#
kinetic law: MODEL1310110063#
product: MODEL1310110063#
reversible: false

metaM decdicrn c
is: HMDB13325
initial concentration: 1.0
name: decadienoyl carnitine
type: Species
is: SBO:0000247
notes: FORMULA: C17H29NO4 CHARGE: 0
constant: false
has only substance units: false
boundary condition: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110063#_2437b2a9_0227_4bfe_ae9b_7e50490d6d9c
boundary condition: true
initial concentration: NaN
has only substance units: false
is: P04054
is: SBO:0000252
is encoded by: hsa:5319
type: Species
initial amount: NaN
constant: false
name: PLA2G1B

http://identifiers.org/biomodels.db/MODEL1310110063#_255bc72b_831e_4c85_8907_ead6e2361088
is: D6RBB5
type: Species
initial amount: NaN
is encoded by: hsa:4258
name: MGST2
constant: false
has only substance units: false
initial concentration: NaN
is: SBO:0000252
boundary condition: true

metaR r1621
fast: false
modifier: MODEL1310110063#
is: SBO:0000185
reactant: MODEL1310110063#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
notes: GENE_ASSOCIATION: (19.1) or (AL038231.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is described by: ECO:0000000
type: Reaction
reversible: true
product: MODEL1310110063#
kinetic law: MODEL1310110063#

http://identifiers.org/biomodels.db/MODEL1310110063#_46b50360_a920_460c_b2d2_ccd20c91fa55
boundary condition: true
type: Species
is: SBO:0000252
has only substance units: false
is: P23743
initial concentration: NaN
constant: false
initial amount: NaN
name: DGKA
is encoded by: hsa:1606

metaM gtp c
initial concentration: 1.0
notes: FORMULA: C10H12N5O14P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00051 EHMN_ABBREVIATION: C00044
initial amount: NaN
is: CHEBI:37565
constant: false
boundary condition: false
has only substance units: false
name: GTP
type: Species
is: SBO:0000247
is: HMDB01273
is: C00044

metaM hdca r
has only substance units: false
is: HMDB00220
boundary condition: false
name: Hexadecanoate (n-C16:0)
is: CHEBI:7896
notes: FORMULA: C16H31O2 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00226 EHMN_ABBREVIATION: C00249
initial concentration: 1.0
is: SBO:0000247
type: Species
constant: false
is: C00249
initial amount: NaN

metaM tdec4ecoa m
has only substance units: false
type: Species
name: trans4decenoylcoa
notes: FORMULA: C31H48N7O17P3S CHARGE: -4
constant: false
is: HMDB00792
initial concentration: 1.0
boundary condition: false
initial amount: NaN
is: SBO:0000247
is: C08277

metaR EX 5dhf LPAREN e RPAREN
kinetic law: MODEL1310110063#
reactant: MODEL1310110063#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: pentaglutamyl folate (DHF) exchange
type: Reaction

metaM ksi pre10 g
notes: FORMULA: C129H209N9O98S2X CHARGE: -3
type: Species
initial amount: NaN
boundary condition: false
initial concentration: 1.0
constant: false
is: CHEBI:58053
name: keratan sulfate I biosynthesis, precursor 10
is: C00130
is: SBO:0000247
is: HMDB00175
has only substance units: false

metaR r0470
name: 2-Deoxyadenosine 5-diphosphate:oxidized-thioredoxin 2-oxidoreductase Purine metabolism EC:1.17.4.1
product: MODEL1310110063#
notes: GENE_ASSOCIATION: SUBSYSTEM: Nucleotide interconversion EC Number: 1.17.4.1 Confidence Level: 0 AUTHORS: PMID:6121703,PMID:8074691 NOTES:
reversible: true
reactant: MODEL1310110063#
fast: false
is: SBO:0000176
type: Reaction
is described by: ECO:0000000
kinetic law: MODEL1310110063#

metaR G14T13g
product: MODEL1310110063#
reactant: MODEL1310110063#
modifier: MODEL1310110063#
name: beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase, Golgi
type: Reaction
is: SBO:0000176
reversible: false
notes: GENE_ASSOCIATION: (8703.1) or (2683.1) or (8704.2) or (8704.1) or (9334.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.38 Confidence Level: 4 AUTHORS: PMID:12512857,PMID:1903938,PMID:3094506,PMID:3144273,PMID:9405390,PMID:9435216 NOTES:Keratan sulfate I biosynthesis NCD
is version of: http://identifiers.org/ec-code/2.4.1.22
is version of: http://identifiers.org/ec-code/2.4.1.38
is described by: ECO:0000000
fast: false
kinetic law: MODEL1310110063#
is version of: http://identifiers.org/ec-code/2.4.1.90

metaR EX gchola LPAREN e RPAREN
kinetic law: MODEL1310110063#
reactant: MODEL1310110063#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Glycocholate exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110063#_aa00bca2_5485_4b7d_a82a_c4502ff4b2f7
is: P59796
initial concentration: NaN
name: GPX6
is: SBO:0000252
constant: false
type: Species
initial amount: NaN
is encoded by: hsa:257202
has only substance units: false
boundary condition: true

metaR r0680
kinetic law: MODEL1310110063#
is described by: ECO:0000000
name: ATP:pantothenate 4-phosphotransferase Pantothenate and CoA biosynthesis EC:2.7.1.33
is: SBO:0000176
type: Reaction
product: MODEL1310110063#
reversible: true
modifier: MODEL1310110063#
is version of: http://identifiers.org/ec-code/2.3.1.137
notes: GENE_ASSOCIATION: (AI373818.1) or (54677.1) SUBSYSTEM: CoA catabolism EC Number: 2.7.1.33 Confidence Level: 0 AUTHORS: PMID:10625688,PMID:13630913,PMID:15105273,PMID:15659606,PMID:16040613 NOTES:
reactant: MODEL1310110063#
fast: false

http://identifiers.org/biomodels.db/MODEL1310110063#_ec3ecddf_ca0f_4dfe_8467_9f404046dfcd
constant: false
is: SBO:0000252
name: SGPP1
type: Species
initial concentration: NaN
is: Q9BX95
boundary condition: true
initial amount: NaN
has only substance units: false
is encoded by: hsa:81537

metaM hmgcoa x
is: SBO:0000247
is: HMDB01375
has only substance units: false
name: Hydroxymethylglutaryl-CoA
initial concentration: 1.0
constant: false
notes: FORMULA: C27H39N7O20P3S CHARGE: -5 INCHI: InChI=1S/C27H44N7O20P3S/c1-26(2,21(40)24(41)30-5-4-15(35)29-6-7-58-17(38)9-27(3,42)8-16(36)37)11-51-57(48,49)54-56(46,47)50-10-14-20(53-55(43,44)45)19(39)25(52-14)34-13-33-18-22(28)31-12-32-23(18)34/h12-14,19-21,25,39-40,42H,4-11H2,1-3H3,(H,29,35)(H,30,41)(H,36,37)(H,46,47)(H,48,49)(H2,28,31,32)(H2,43,44,45)/t14-,19-,20-,21+,25-,27+/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00302 EHMN_ABBREVIATION: C00356
initial amount: NaN
is: CHEBI:15467
type: Species
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110063#_a9158374_228e_42cc_afa8_208b2e037049
is encoded by: hsa:5152
type: Species
initial amount: NaN
constant: false
has only substance units: false
boundary condition: true
is: SBO:0000252
initial concentration: NaN
name: PDE9A

metaR AG13T6g
product: MODEL1310110063#
kinetic law: MODEL1310110063#
notes: GENE_ASSOCIATION: (79369.1) or (374907.1) or (11041.1) or (146712.1) or (374907.2) or (93010.1) or (10331.1) or (10678.1) or (10678.2) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.149 Confidence Level: 4 AUTHORS: PMID:10747980,PMID:11042166,PMID:12061784,PMID:12512857,PMID:15560372,PMID:15620693,PMID:9405606 NOTES:NCD
reactant: MODEL1310110063#
type: Reaction
is: SBO:0000176
reversible: false
is version of: http://identifiers.org/ec-code/2.4.1.149
modifier: MODEL1310110063#
name: N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase, Golgi apparatus
fast: false
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110063#_2cfe6334_7f35_4588_8685_d83f0aacfc1c
type: Species
initial amount: NaN
is: SBO:0000252
initial concentration: NaN
name: GLB1
has only substance units: false
is encoded by: hsa:2720
constant: false
boundary condition: true
is: P16278

metaR HDCACBP
kinetic law: MODEL1310110063#
product: MODEL1310110063#
reactant: MODEL1310110063#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: transport of (S)-3-Hydroxydecanoyl-CoA from mitochondria into the cytosol
type: Reaction

metaR EX 5adtststerones LPAREN e RPAREN
kinetic law: MODEL1310110063#
reactant: MODEL1310110063#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 5alpha-Dihydrotestosterone sulfate exchange
type: Reaction

metaR NTP3e
modifier: MODEL1310110063#
type: Reaction
notes: GENE_ASSOCIATION: (124583.1) SUBSYSTEM: Nucleotide interconversion EC Number: 3.6.1.15 Confidence Level: 4 AUTHORS: PMID:12234496,PMID:12600208 NOTES:
is version of: http://identifiers.org/ec-code/3.6.1.6
name: nucleoside-triphosphatase (GTP)
fast: false
kinetic law: MODEL1310110063#
reversible: false
is: SBO:0000176
product: MODEL1310110063#
reactant: MODEL1310110063#
is described by: ECO:0000269

http://identifiers.org/biomodels.db/MODEL1310110063#_bb21df67_e797_4150_aaf3_894095d9d087
is encoded by: hsa:7359
constant: false
type: Species
initial concentration: NaN
name: _7359_1_c
is: SBO:0000252
boundary condition: true
initial amount: NaN
has only substance units: false

metaM 3tetd7ecoacrn c
constant: false
name: 3-hydroxy tetradecenoyl-7-carnitine
initial amount: NaN
notes: FORMULA: C21H39NO5 CHARGE: 0
type: Species
is: SBO:0000247
is: HMDB02014
initial concentration: 1.0
boundary condition: false
has only substance units: false

metaR EX lac L LPAREN e RPAREN
kinetic law: MODEL1310110063#
reactant: MODEL1310110063#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: L-Lactate exchange
type: Reaction

metaR r0317
is described by: ECO:0000000
fast: false
kinetic law: MODEL1310110063#
reactant: MODEL1310110063#
modifier: MODEL1310110063#
reversible: true
product: MODEL1310110063#
notes: GENE_ASSOCIATION: (AI761708.1) or (275.1) or (1738.1) or (2731.1) SUBSYSTEM: Unassigned EC Number: 4.2.1.4 Confidence Level: 0 AUTHORS: PMID:15263083,PMID:16511074 NOTES:
is version of: http://identifiers.org/ec-code/1.4.4.2
is version of: http://identifiers.org/ec-code/2.1.2.10
name: citrate hydro-lyase Citrate cycle (TCA cycle) / Glyoxylate and dicarboxylate metabolism EC:4.2.1.4
is: SBO:0000176
type: Reaction
is version of: http://identifiers.org/ec-code/1.8.1.4

metaR XYLtly
product: MODEL1310110063#
reactant: MODEL1310110063#
reversible: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 1 AUTHORS: PMID:1751541,PMID:8993166 NOTES:NCD
name: Xylose efflux from lysosome
fast: false
is described by: ECO:0000000
type: Reaction
kinetic law: MODEL1310110063#
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110063#_53c55e8a_5db2_42ce_bac5_b4d9c4f1300f
constant: false
is encoded by: hsa:AI926493
has only substance units: false
initial amount: NaN
boundary condition: true
initial concentration: NaN
name: _AI926493_1_c
type: Species
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110063#_ef5dd0c0_0496_41c0_afdf_3d26ab9b6468
has part: P36957
is encoded by: hsa:8050
type: Species
is encoded by: hsa:1738
initial amount: NaN
name: DLD:DLST:OGDH:PDHX
is: SBO:0000297
is encoded by: hsa:4967
is encoded by: hsa:1743
has part: P09622
has part: O00330
has part: Q02218
has only substance units: false
boundary condition: true
constant: false
initial concentration: NaN

metaR KSII CORE2tly
kinetic law: MODEL1310110063#
reversible: false
is: SBO:0000185
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 2 AUTHORS: NOTES:
fast: false
is described by: ECO:0000000
product: MODEL1310110063#
reactant: MODEL1310110063#
name: keratan sulfate II (core 2) transport, extracellular to lysosome

metaR FAOXC16180m
fast: false
name: Beta oxidation fatty acid
type: Reaction
is: SBO:0000176
notes: GENE_ASSOCIATION: (35.1) or (34.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.74 Confidence Level: 4 AUTHORS: NOTES:_4 rounds of beta ox, 1 loss of degree of unsat -> only 3 fad oxidized c16:1 -> c8:0 4 step FAO lumped for 2 rounds also includes EC 1.1.1.35, 1.1.1.211, 1.3.3.6, 4.2.1.17, 4.2.1.74 NJ
is described by: ECO:0000269
modifier: MODEL1310110063#
kinetic law: MODEL1310110063#
product: MODEL1310110063#
is version of: http://identifiers.org/ec-code/1.3.8.1
reversible: false
is version of: http://identifiers.org/ec-code/1.3.99.3
reactant: MODEL1310110063#

http://identifiers.org/biomodels.db/MODEL1310110063#_6fc504e8_1779_4fee_894a_3aa5a7389106
name: SGMS1
is: SBO:0000252
initial concentration: NaN
has only substance units: false
constant: false
is encoded by: hsa:259230
initial amount: NaN
type: Species
is: D3DWC4
boundary condition: true

metaR r1630
reactant: MODEL1310110063#
product: MODEL1310110063#
reversible: true
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
kinetic law: MODEL1310110063#
fast: false
is described by: ECO:0000000
is: SBO:0000185
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:

metaM cs a l
constant: false
name: chondroitin sulfate A (GalNAc4S-GlcA), free chain
type: Species
boundary condition: false
notes: FORMULA: C45H67N2O46S3 CHARGE: -5
initial amount: NaN
initial concentration: 1.0
has only substance units: false
is: CHEBI:36005
is: SBO:0000247
is: HMDB02183

metaM succ m
constant: false
is: C00042
type: Species
is: CHEBI:30031
initial concentration: 1.0
is: HMDB00254
initial amount: NaN
boundary condition: false
is: SBO:0000247
has only substance units: false
name: Succinate
notes: FORMULA: C4H4O4 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00049 EHMN_ABBREVIATION: C00042

metaR G14T4g
product: MODEL1310110063#
is version of: http://identifiers.org/ec-code/2.4.1.38
notes: GENE_ASSOCIATION: (8703.1) or (2683.1) or (8704.2) or (8704.1) or (9334.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.38 Confidence Level: 4 AUTHORS: PMID:12512857,PMID:1903938,PMID:3094506,PMID:3144273,PMID:9405390,PMID:9435216 NOTES:Keratan sulfate II biosynthesis NCD
modifier: MODEL1310110063#
reversible: false
reactant: MODEL1310110063#
type: Reaction
name: beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase, Golgi
fast: false
kinetic law: MODEL1310110063#
is version of: http://identifiers.org/ec-code/2.4.1.22
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.4.1.90
is described by: ECO:0000000

metaR EX CE1943 LPAREN e RPAREN
kinetic law: MODEL1310110063#
reactant: MODEL1310110063#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: spermidine dialdehyde exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110063#_52eaf1a5_e489_41f6_8b24_2f54b9be6a35
type: Species
initial concentration: NaN
is: SBO:0000252
constant: false
initial amount: NaN
name: MAN1B1
is encoded by: hsa:11253
has only substance units: false
is: Q9UKM7
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110063#_768b8ccd_96d6_45e6_b9f1_c6ba98f0335c
is: Q2TU34
name: FBP1
boundary condition: true
is encoded by: hsa:2203
has only substance units: false
type: Species
is: SBO:0000252
constant: false
initial concentration: NaN
initial amount: NaN

metaM HC01522 c
has only substance units: false
initial amount: NaN
is: SBO:0000247
constant: false
name: Gentisate aldehyde
type: Species
is: CHEBI:28508
notes: FORMULA: C7H6O3 CHARGE: 0 INCHI: InChI=1S/C7H6O3/c8-4-5-3-6(9)1-2-7(5)10/h1-4,9-10H EHMN_ABBREVIATION: C05585
boundary condition: false
initial concentration: 1.0

metaR PYDAMK
is: SBO:0000176
reversible: false
type: Reaction
notes: GENE_ASSOCIATION: (8566.1) SUBSYSTEM: Vitamin B6 metabolism EC Number: Confidence Level: 4 AUTHORS: NOTES:
is version of: http://identifiers.org/ec-code/2.7.1.35
fast: false
modifier: MODEL1310110063#
reactant: MODEL1310110063#
kinetic law: MODEL1310110063#
is described by: ECO:0000269
name: pyridoxamine kinase
product: MODEL1310110063#

http://identifiers.org/biomodels.db/MODEL1310110063#_1e868f21_d8b6_4661_80d6_9904fcbc1d77
is encoded by: hsa:2643
type: Species
name: GCH1
initial amount: NaN
is: Q8IZH9
constant: false
is: SBO:0000252
has only substance units: false
initial concentration: NaN
boundary condition: true

metaR P5CDm
name: 1-pyrroline-5-carboxylate dehydrogenase, mitochondrial
fast: false
is version of: http://identifiers.org/ec-code/1.5.1.12
modifier: MODEL1310110063#
reversible: false
kinetic law: MODEL1310110063#
is: SBO:0000176
reactant: MODEL1310110063#
notes: GENE_ASSOCIATION: (8659.1) or (8659.2) SUBSYSTEM: Glutamate metabolism EC Number: 1.5.1.12 Confidence Level: 4 AUTHORS: PMID:8621661,PMID:9700195 NOTES:NCD
product: MODEL1310110063#
is described by: ECO:0000269
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110063#_2817805f_6f87_4b42_a735_b7a1f294d1cb
constant: false
initial amount: NaN
has only substance units: false
initial concentration: NaN
name: ATP5I
is encoded by: hsa:521
is: P56385
boundary condition: true
type: Species
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110063#_e1a81453_f69f_4280_87a0_e6b8e3aff401
has only substance units: false
is encoded by: hsa:285973
type: Species
constant: false
initial amount: NaN
initial concentration: NaN
name: ATG9B
boundary condition: true
is: SBO:0000252
is: Q674R7

http://identifiers.org/biomodels.db/MODEL1310110063#_b5a657c1_17ca_4008_a9ba_85bf7e9b1cf5
is: SBO:0000252
type: Species
has only substance units: false
is: O00154
constant: false
name: ACOT7
boundary condition: true
is encoded by: hsa:11332
initial concentration: NaN
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110063#_0e64b81b_844e_4901_8ca0_6c68881083b3
name: MAN2B1
is encoded by: hsa:4125
type: Species
initial amount: NaN
constant: false
is: SBO:0000252
initial concentration: NaN
boundary condition: true
is: O00754
has only substance units: false

metaR GLNtN1
notes: GENE_ASSOCIATION: (92745.1) or (10991.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10823827,PMID:12845534 NOTES:SAB based om PMID 10823827
product: MODEL1310110063#
reversible: true
fast: false
name: Glutamine transport (Na, H coupled)
type: Reaction
reactant: MODEL1310110063#
kinetic law: MODEL1310110063#
is: SBO:0000185
is described by: ECO:0000269
modifier: MODEL1310110063#

metaR RE3241R
modifier: MODEL1310110063#
name: RE3241
kinetic law: MODEL1310110063#
fast: false
product: MODEL1310110063#
reactant: MODEL1310110063#
reversible: false
is described by: ECO:0000000
type: Reaction
notes: GENE_ASSOCIATION: (64834.1) SUBSYSTEM: Fatty acid synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:10970790 NOTES:
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110063#_dda94be0_0fec_495f_a426_483f58600666
constant: false
initial amount: NaN
boundary condition: true
type: Species
name: IVD
is: B3KVI7
is encoded by: hsa:3712
has only substance units: false
initial concentration: NaN
is: SBO:0000252

metaR RE2996X
reactant: MODEL1310110063#
modifier: MODEL1310110063#
is described by: ECO:0000000
name: RE2996
fast: false
is: SBO:0000176
notes: GENE_ASSOCIATION: (26063.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.1.34 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:7775433 NOTES:
reversible: true
kinetic law: MODEL1310110063#
is version of: http://identifiers.org/ec-code/1.3.1.34
type: Reaction
product: MODEL1310110063#

metaR r1631
reactant: MODEL1310110063#
product: MODEL1310110063#
is described by: ECO:0000000
type: Reaction
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
kinetic law: MODEL1310110063#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is: SBO:0000185
reversible: true

metaR NADPtxu
reversible: false
fast: false
is: SBO:0000185
reactant: MODEL1310110063#
name: NADP transporter, peroxisome
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 1 AUTHORS: PMID:10521434 NOTES:diffusion - unidirectional to avoid NADP/NAD loops w/ potential for free H NJ
is described by: ECO:0000000
kinetic law: MODEL1310110063#
type: Reaction
product: MODEL1310110063#

metaR EX arg L LPAREN e RPAREN
kinetic law: MODEL1310110063#
reactant: MODEL1310110063#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: L-Arginine exchange
type: Reaction

metaR P45027A1m
reactant: MODEL1310110063#
type: Reaction
modifier: MODEL1310110063#
is described by: ECO:0000269
product: MODEL1310110063#
kinetic law: MODEL1310110063#
fast: false
name: Cytochrome P450 27
is version of: http://identifiers.org/ec-code/1.14.13.15
is: SBO:0000176
notes: GENE_ASSOCIATION: (1593.1) SUBSYSTEM: Bile acid synthesis EC Number: Confidence Level: 4 AUTHORS: NOTES:
reversible: false

metaR RE1532M
kinetic law: MODEL1310110063#
modifier: MODEL1310110063#
fast: false
is version of: http://identifiers.org/ec-code/2.3.1.16
is: SBO:0000176
name: RE1532
type: Reaction
notes: GENE_ASSOCIATION: (10449.1) or (3032.1) or (3030.1) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.16 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:7775433,PMID:7923814,PMID:9568246,PMID:9920399 NOTES:
is version of: http://identifiers.org/ec-code/4.2.1.17
reactant: MODEL1310110063#
is described by: ECO:0000000
product: MODEL1310110063#
reversible: true

metaM cs b deg2 l
boundary condition: false
initial concentration: 1.0
is: CHEBI:57455
constant: false
has only substance units: false
is: SBO:0000247
name: chondroitin sulfate B / dermatan sulfate (IdoA2S-GalNAc4S), degradation product 2
notes: FORMULA: C37H54NO41S3 CHARGE: -5
is: HMDB01354
initial amount: NaN
type: Species

http://identifiers.org/biomodels.db/MODEL1310110063#_290832fd_82c1_4ae2_9bbe_1c274e0da799
constant: false
boundary condition: true
is: Q6NSB3
type: Species
initial amount: NaN
initial concentration: NaN
has only substance units: false
name: AMY1A
is encoded by: hsa:276
is: SBO:0000252

metaR CYSSNAT5tc
kinetic law: MODEL1310110063#
product: MODEL1310110063#
reactant: MODEL1310110063#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: transport of L-Cysteine into the cell coupled with co-transport with Sodium and counter transport with proton by SNAT5 transporter.
type: Reaction

metaM paps g
is: HMDB01134
is: SBO:0000247
boundary condition: false
is: CHEBI:58339
name: (2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-4-hydroxy-2-({[(sulfonatooxy)phosphinato]oxy}methyl)oxolan-3-yl phosphate
initial amount: NaN
type: Species
has only substance units: false
notes: FORMULA: C10H11N5O13P2S CHARGE: -4 INCHI: InChI=1S/C10H15N5O13P2S/c11-8-5-9(13-2-12-8)15(3-14-5)10-6(16)7(27-29(17,18)19)4(26-10)1-25-30(20,21)28-31(22,23)24/h2-4,6-7,10,16H,1H2,(H,20,21)(H2,11,12,13)(H2,17,18,19)(H,22,23,24)/p-4/t4-,6-,7-,10-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00058 EHMN_ABBREVIATION: C00053
initial concentration: 1.0
constant: false

metaR r1632
modifier: MODEL1310110063#
kinetic law: MODEL1310110063#
is described by: ECO:0000000
is: SBO:0000185
notes: GENE_ASSOCIATION: (57835.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
type: Reaction
fast: false
product: MODEL1310110063#
reversible: true
reactant: MODEL1310110063#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1

metaM ump n
is: SBO:0000247
initial amount: NaN
boundary condition: false
type: Species
is: CHEBI:57865
notes: FORMULA: C9H11N2O9P CHARGE: -2 INCHI: InChI=1S/C9H13N2O9P/c12-5-1-2-11(9(15)10-5)8-7(14)6(13)4(20-8)3-19-21(16,17)18/h1-2,4,6-8,13-14H,3H2,(H,10,12,15)(H2,16,17,18)/p-2/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00105 EHMN_ABBREVIATION: C00105
constant: false
initial concentration: 1.0
has only substance units: false
is: HMDB00288
name: UMP(2-)

metaM estrones c
is: CHEBI:60050
notes: FORMULA: C18H21O5S CHARGE: -1 INCHI: InChI=1S/C18H22O5S/c1-18-9-8-14-13-5-3-12(23-24(20,21)22)10-11(13)2-4-15(14)16(18)6-7-17(18)19/h3,5,10,14-16H,2,4,6-9H2,1H3,(H,20,21,22)/p-1/t14-,15-,16+,18+/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00961 EHMN_ABBREVIATION: C02538
constant: false
name: estrone 3-sulfate(1-)
boundary condition: false
has only substance units: false
initial amount: NaN
is: SBO:0000247
initial concentration: 1.0
is: HMDB01425
type: Species

http://identifiers.org/biomodels.db/MODEL1310110063#_5be8c8a0_28d2_496f_9ea9_bde47edf28db
has only substance units: false
name: UGP2
initial concentration: NaN
type: Species
initial amount: NaN
boundary condition: true
constant: false
is: SBO:0000252
is encoded by: hsa:7360
is: Q16851

http://identifiers.org/biomodels.db/MODEL1310110063#_9eb3289d_4879_4979_96b3_56e32654a1d0
boundary condition: true
is: SBO:0000252
constant: false
initial amount: NaN
type: Species
name: SLC9A5
initial concentration: NaN
is: Q9NSW9
is encoded by: hsa:6553
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110063#_695ed01d_76aa_4664_95bb_91c5d0d2d77b
has only substance units: false
constant: false
initial concentration: NaN
is encoded by: hsa:AI348006
is: SBO:0000252
boundary condition: true
type: Species
initial amount: NaN
name: _AI348006_1_c

metaR APOC LYS BTNPm
type: Reaction
kinetic law: MODEL1310110063#
is described by: ECO:0000000
reversible: false
fast: false
name: proteolysis of apoC-Lys-btn, mitochondrial
reactant: MODEL1310110063#
product: MODEL1310110063#
notes: GENE_ASSOCIATION: SUBSYSTEM: Biotin metabolism EC Number: Confidence Level: 2 AUTHORS: NOTES:
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110063#_3c7c23ba_7b94_42d1_a4ee_d91ae1f2fbd5
initial concentration: NaN
initial amount: NaN
type: Species
is encoded by: hsa:7296
is: SBO:0000252
boundary condition: true
constant: false
name: TXNRD1
has only substance units: false

metaR BTNt4i
notes: GENE_ASSOCIATION: (80704.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14770311,PMID:15623830 NOTES:IT
product: MODEL1310110063#
is: SBO:0000185
reactant: MODEL1310110063#
is described by: ECO:0000269
modifier: MODEL1310110063#
reversible: false
kinetic law: MODEL1310110063#
fast: false
name: Biotin uptake (antiport)
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110063#_834e4f8d_f7ae_4789_8466_79eabf9be50c
type: Species
constant: false
has only substance units: false
initial concentration: NaN
is: Q5DSZ6
is: SBO:0000252
boundary condition: true
is encoded by: hsa:54576
name: UGT1A8
initial amount: NaN

metaM o2 e
name: O2
is: HMDB01377
is: SBO:0000247
is: C00007
initial concentration: 1.0
boundary condition: false
notes: FORMULA: O2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00017 EHMN_ABBREVIATION: C00007
has only substance units: false
is: CHEBI:15379
initial amount: NaN
type: Species
constant: false

http://identifiers.org/biomodels.db/MODEL1310110063#_4f267fa3_1f87_4a6f_96b6_4d33bea17e64
has only substance units: false
initial amount: NaN
constant: false
boundary condition: true
initial concentration: NaN
is: Q96CA6
name: ACAA1
type: Species
is encoded by: hsa:30
is: SBO:0000252

metaM aprgstrn e
boundary condition: false
is: SBO:0000247
type: Species
is: CHEBI:28453
constant: false
notes: FORMULA: C21H32O2 CHARGE: 0 INCHI: InChI=1S/C21H32O2/c1-13(22)17-6-7-18-16-5-4-14-12-15(23)8-10-20(14,2)19(16)9-11-21(17,18)3/h12-13,16-19,22H,4-11H2,1-3H3/t13-,16-,17+,18-,19-,20-,21+/m0/s1 EHMN_ABBREVIATION: C04042
name: (20S)-20-hydroxypregn-4-en-3-one
has only substance units: false
is: HMDB03069
initial concentration: 1.0
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110063#_338ae469_b945_4127_857b_778ac784e1b0
has only substance units: false
is: O14561
name: NDUFAB1
type: Species
initial concentration: NaN
is: SBO:0000252
initial amount: NaN
boundary condition: true
is encoded by: hsa:4706
constant: false

metaR r0531
product: MODEL1310110063#
is version of: http://identifiers.org/ec-code/1.1.1.34
notes: GENE_ASSOCIATION: (3156.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.1.48 Confidence Level: 0 AUTHORS: PMID:11306702,PMID:9923963 NOTES:
is described by: ECO:0000000
fast: false
reactant: MODEL1310110063#
is: SBO:0000176
reversible: true
kinetic law: MODEL1310110063#
name: dUTP:cytidine 5-phosphotransferase Pyrimidine metabolism EC:2.7.1.48
type: Reaction
modifier: MODEL1310110063#

http://identifiers.org/biomodels.db/MODEL1310110063#_4edf5cbb_bbb4_49b5_a88f_fe0d3d8a7549
initial concentration: NaN
type: Species
initial amount: NaN
boundary condition: true
is encoded by: hsa:55089
has only substance units: false
name: SLC38A4
is: Q969I6
constant: false
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110063#_85a821e5_9a2c_423e_a250_3bdc75c2e98b
has only substance units: false
is: SBO:0000252
type: Species
constant: false
name: MTMR3
initial concentration: NaN
initial amount: NaN
boundary condition: true
is encoded by: hsa:8897

http://identifiers.org/biomodels.db/MODEL1310110063#_3f2a8bec_5279_4355_b67f_b077e93b7536
initial amount: NaN
name: _AA526438_1_m
constant: false
is: SBO:0000252
initial concentration: NaN
is encoded by: hsa:AA526438
has only substance units: false
type: Species
boundary condition: true

metaM ribflv e
is: HMDB00244
is: SBO:0000247
notes: FORMULA: C17H20N4O6 CHARGE: 0
constant: false
name: Riboflavin
type: Species
is: CHEBI:3554
initial amount: NaN
boundary condition: false
has only substance units: false
initial concentration: 1.0
is: C00255

metaR EX thym LPAREN e RPAREN
kinetic law: MODEL1310110063#
reactant: MODEL1310110063#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Thymine exchange
type: Reaction

metaM ocdececrn c
is: HMDB06351
initial amount: NaN
notes: FORMULA: C25H47NO4 CHARGE: 0
is: SBO:0000247
boundary condition: false
name: 11-octadecenoyl carnitine
constant: false
type: Species
has only substance units: false
initial concentration: 1.0

metaR S6T10g
fast: false
is: SBO:0000176
type: Reaction
notes: GENE_ASSOCIATION: (23563.2) or (9435.1) or (23563.1) or (10164.1) or (4166.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: Confidence Level: 4 AUTHORS: PMID:10330415,PMID:10491328,PMID:10913333,PMID:11278593,PMID:12403612,PMID:12855678,PMID:9722682 NOTES:NCD
modifier: MODEL1310110063#
reactant: MODEL1310110063#
is described by: ECO:0000000
name: galactose/N-acetylglucosamine 6-O-sulfotransferase, Golgi apparatus
reversible: false
kinetic law: MODEL1310110063#
product: MODEL1310110063#

metaR NDP10ex
kinetic law: MODEL1310110063#
notes: GENE_ASSOCIATION: (124583.1) SUBSYSTEM: Nucleotide interconversion EC Number: 3.6.1.6 Confidence Level: 4 AUTHORS: PMID:12234496,PMID:12600208 NOTES:IT
modifier: MODEL1310110063#
reversible: false
fast: false
reactant: MODEL1310110063#
type: Reaction
name: nucleoside-diphosphatase (IDP), extracellular
product: MODEL1310110063#
is described by: ECO:0000269
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.6.1.6

metaR C142OHc
kinetic law: MODEL1310110063#
product: MODEL1310110063#
reactant: MODEL1310110063#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: production of 3-hydroxytetradeca dienoyl carnitine
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110063#_fb8d911b_2da4_4e3c_83d3_dbbb8952dc2b
is: Q92523
boundary condition: true
is encoded by: hsa:1375
initial concentration: NaN
is: SBO:0000252
type: Species
constant: false
name: CPT1B
has only substance units: false
initial amount: NaN

metaR NADH2 u10m
fast: false
reversible: false
product: MODEL1310110063#
name: NADH dehydrogenase, mitochondrial
notes: GENE_ASSOCIATION: (4715.1) and (4720.1) and (4719.1) and (55967.1) and (4700.1) and (4709.1) and (4710.1) and (4726.1) and (4696.1) and (4718.1) and (4694.1) and (374291.1) and (4728.1) and (4717.1) and (4731.1) and (4705.1) and (4725.1) and (4716.1) and (4537.1) and (4722.1) and (7991.1) and (4541.1) and (4539.1) and (4712.1) and (4707.1) and (4701.1) and (4723.1) and (4698.1) and (4538.1) and (4697.1) and (51079.1) and (4714.1) and (4704.1) and (4711.1) and (126328.1) and (4724.1) and (4713.1) and (4536.1) and (4695.1) and (4702.1) and (4708.1) and (4706.1) and (4535.1) and (4540.1) and (4729.1) or (4715.1) and (4720.1) and (4719.1) and (4700.1) and (55967.1) and (4709.1) and (4710.1) and (4726.1) and (4718.1) and (4696.1) and (4694.1) and (374291.1) and (4728.1) and (4712.2) and (4717.1) and (4705.1) and (4725.1) and (4716.1) and (4537.1) and (7991.1) and (4722.1) and (4541.1) and (4539.1) and (4707.1) and (4701.1) and (4723.1) and (4698.1) and (4538.1) and (4697.1) and (51079.1) and (4714.1) and (4704.1) and (126328.1) and (4711.1) and (4724.1) and (4713.1) and (4536.1) and (4695.1) and (4702.1) and (4708.1) and (4535.1) and (4731.2) and (4706.1) and (4729.1) and (4540.1) or (4715.1) and (4720.1) and (4719.1) and (4700.1) and (55967.1) and (4709.1) and (4710.1) and (4726.1) and (4718.1) and (4696.1) and (4694.1) and (374291.1) and (4728.1) and (7991.2) and (4717.1) and (4705.1) and (4725.1) and (4537.1) and (4716.1) and (4722.1) and (4541.1) and (4712.1) and (4539.1) and (4707.1) and (4701.1) and (4723.1) and (4698.1) and (4538.1) and (4697.1) and (51079.1) and (4714.1) and (4704.1) and (4711.1) and (126328.1) and (4724.1) and (4713.1) and (4536.1) and (4695.1) and (4702.1) and (4708.1) and (4535.1) and (4731.2) and (4706.1) and (4540.1) and (4729.1) or (4715.1) and (4720.1) and (4719.1) and (55967.1) and (4700.1) and (4709.1) and (4710.1) and (4726.1) and (4696.1) and (4718.1) and (374291.1) and (4694.1) and (4728.1) and (4712.2) and (4717.1) and (4731.1) and (…
type: Reaction
is version of: http://identifiers.org/ec-code/1.6.99.3
modifier: MODEL1310110063#
reactant: MODEL1310110063#
is version of: http://identifiers.org/ec-code/1.6.5.3
is described by: ECO:0000134
kinetic law: MODEL1310110063#
is: SBO:0000185

metaR FAOXC12C12OHm
kinetic law: MODEL1310110063#
product: MODEL1310110063#
reactant: MODEL1310110063#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C12-->OHC12)m
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110063#_ec358e37_91f4_44ff_ae75_8455e1bcd47a
name: ENTPD4
type: Species
has only substance units: false
is encoded by: hsa:9583
is: Q9Y227
initial amount: NaN
boundary condition: true
constant: false
initial concentration: NaN
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110063#_0eef6730_c658_435f_9b60_e105631e40c9
is: Q9H845
boundary condition: true
has only substance units: false
constant: false
type: Species
name: ACAD9
is encoded by: hsa:28976
initial amount: NaN
is: SBO:0000252
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110063#_2470659a_da1c_4b33_b27d_b242bc23719d
is: Q7GXY8
name: COX1
type: Species
has only substance units: false
initial concentration: NaN
constant: false
initial amount: NaN
is: SBO:0000252
boundary condition: true
is encoded by: hsa:4512

metaM ribflv c
is: HMDB00244
type: Species
is: C00255
constant: false
has only substance units: false
is: CHEBI:3554
boundary condition: false
initial concentration: 1.0
initial amount: NaN
name: Riboflavin
notes: FORMULA: C17H20N4O6 CHARGE: 0
is: SBO:0000247

metaM ddece1crn c
constant: false
name: dodecenoyl carnitine
initial concentration: 1.0
is: HMDB03712
initial amount: NaN
has only substance units: false
type: Species
notes: FORMULA: C19H35NO4 CHARGE: 0
boundary condition: false
is: SBO:0000247

metaM aprgstrn c
initial amount: NaN
constant: false
notes: FORMULA: C21H32O2 CHARGE: 0 INCHI: InChI=1S/C21H32O2/c1-13(22)17-6-7-18-16-5-4-14-12-15(23)8-10-20(14,2)19(16)9-11-21(17,18)3/h12-13,16-19,22H,4-11H2,1-3H3/t13-,16-,17+,18-,19-,20-,21+/m0/s1 EHMN_ABBREVIATION: C04042
is: CHEBI:28453
boundary condition: false
name: (20S)-20-hydroxypregn-4-en-3-one
type: Species
is: SBO:0000247
initial concentration: 1.0
has only substance units: false
is: HMDB03069

metaR sink 5hpet LPAREN c RPAREN
kinetic law: MODEL1310110063#
reactant: MODEL1310110063#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: sink reaction for 5(S)-HPETE(1-)
type: Reaction

metaM 13 cis retn c
has only substance units: false
initial amount: NaN
constant: false
type: Species
initial concentration: 1.0
is: SBO:0000247
is: http://identifiers.org/pubchem.compound/7847414
boundary condition: false
is: HMDB06219
notes: FORMULA: C20H27O2 CHARGE: -1 INCHI: InChI=1/C20H28O2/c1-15(8-6-9-16(2)14-19(21)22)11-12-18-17(3)10-7-13-20(18,4)5/h6,8-9,11-12,14H,7,10,13H2,1-5H3,(H,21,22)/b9-6+,12-11+,15-8+,16-14- EHMN_ABBREVIATION: CE2952
name: 13-cis-retinoate
is: D00348

metaR DMNONCRNCPT2
kinetic law: MODEL1310110063#
product: MODEL1310110063#
fast: false
reversible: true
type: Reaction
reactant: MODEL1310110063#
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 2 AUTHORS: PMID:9299016,PMID:9819701 NOTES:
name: DMNONCRNCPT2
is described by: ECO:0000000
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110063#_bc01f00e_4dc3_4050_a150_09c477d1fa96
initial concentration: NaN
boundary condition: true
name: _AA278423_1_m
has only substance units: false
is: SBO:0000252
constant: false
type: Species
initial amount: NaN
is encoded by: hsa:AA278423

http://identifiers.org/biomodels.db/MODEL1310110063#_c863d4e8_20fd_41ca_86f6_f3080602f3d3
has only substance units: false
is: SBO:0000252
boundary condition: true
initial concentration: NaN
type: Species
initial amount: NaN
is encoded by: hsa:6785
constant: false
name: ELOVL4
is: Q9GZR5

metaR ACCOAtr
product: MODEL1310110063#
is: SBO:0000185
reversible: true
reactant: MODEL1310110063#
name: acetyl-coa transport
notes: GENE_ASSOCIATION: (9197.1) SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: NOTES:transport between cytosol and Golgi/ER presumed presumed facilitated transport, but unknown co-substrates, see PMID: 12739170, Hirabayashi et al NJ changed name from ACCOArt to ACCOAtr for consistency - NCD
is described by: ECO:0000000
modifier: MODEL1310110063#
fast: false
type: Reaction
kinetic law: MODEL1310110063#

metaM ala L e
has only substance units: false
is: CHEBI:16977
initial amount: NaN
type: Species
initial concentration: 1.0
is: SBO:0000247
is: HMDB00161
constant: false
notes: FORMULA: C3H7NO2 CHARGE: 0 INCHI: InChI=1S/C3H7NO2/c1-2(4)3(5)6/h2H,4H2,1H3,(H,5,6)/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00048
boundary condition: false
name: L-alanine

http://identifiers.org/biomodels.db/MODEL1310110063#_66b7b786_646a_470d_9982_2ebf1e31202d
boundary condition: true
initial amount: NaN
is: Q6ZWP6
is: SBO:0000252
has only substance units: false
type: Species
is encoded by: hsa:27034
constant: false
initial concentration: NaN
name: ACAD8

metaM gar c
type: Species
is: HMDB02022
constant: false
initial amount: NaN
initial concentration: 1.0
boundary condition: false
is: SBO:0000247
notes: FORMULA: C7H14N2O8P CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC01190 EHMN_ABBREVIATION: C03838
has only substance units: false
is: C03838
name: N1-(5-Phospho-D-ribosyl)glycinamide
is: CHEBI:58457

http://identifiers.org/biomodels.db/MODEL1310110063#_e6e9c671_fc1b_4da2_9108_3fb4f1fba11e
has only substance units: false
initial concentration: NaN
initial amount: NaN
type: Species
boundary condition: true
is: SBO:0000252
constant: false
is encoded by: hsa:W87865
name: _W87865_1_c

metaR C142OHe
kinetic law: MODEL1310110063#
product: MODEL1310110063#
reactant: MODEL1310110063#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: excretion of C14:2-OH
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110063#_a72cf7a5_97c6_49e6_8acb_f09b48e42afb
boundary condition: true
initial amount: NaN
type: Species
is encoded by: hsa:10998
constant: false
has only substance units: false
name: SLC27A5
is: Q9Y2P5
initial concentration: NaN
is: SBO:0000252

metaM dcmp n
is: HMDB01202
boundary condition: false
is: CHEBI:57566
has only substance units: false
initial amount: NaN
initial concentration: 1.0
notes: FORMULA: C9H12N3O7P CHARGE: -2 INCHI: InChI=1S/C9H14N3O7P/c10-7-1-2-12(9(14)11-7)8-3-5(13)6(19-8)4-18-20(15,16)17/h1-2,5-6,8,13H,3-4H2,(H2,10,11,14)(H2,15,16,17)/p-2/t5-,6+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00217 EHMN_ABBREVIATION: C00239
type: Species
constant: false
is: SBO:0000247
name: dCMP(2-)

metaR LALDO
name: D-Lactaldehyde:NAD+ oxidoreductase (glutathione-formylating)
modifier: MODEL1310110063#
is: SBO:0000176
type: Reaction
reversible: true
is version of: http://identifiers.org/ec-code/1.1.1.1
fast: false
product: MODEL1310110063#
reactant: MODEL1310110063#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (128.1) SUBSYSTEM: Pyruvate metabolism EC Number: 1.1.1.1 Confidence Level: 0 AUTHORS: NOTES:EC 1.2.1.1 NCD
kinetic law: MODEL1310110063#

metaR ALCD21 L
kinetic law: MODEL1310110063#
modifier: MODEL1310110063#
reactant: MODEL1310110063#
is version of: http://identifiers.org/ec-code/1.1.1.1
name: alcohol dehydrogenase (L-1,2-propanediol)
type: Reaction
notes: GENE_ASSOCIATION: (130.1) or (125.1) or (125.1 and 124.1) or (128.1) or (126.1) or (284273.2) or (137872.1) or (127.1) or (124.1) or (126.1 and 124.1) or (284273.1) or (125.1 and 126.1) or (131.1) SUBSYSTEM: Pyruvate metabolism EC Number: 1.1.1.1 Confidence Level: 2 AUTHORS: PMID:15987839,PMID:2296157 NOTES:NCD
is: SBO:0000176
reversible: false
is version of: http://identifiers.org/ec-code/1.1.99.24
product: MODEL1310110063#
fast: false
is described by: ECO:0000304

metaR r1418
is described by: ECO:0000000
is: SBO:0000176
product: MODEL1310110063#
reactant: MODEL1310110063#
name: Carbonic acid hydro-lyase Nitrogen metabolism EC:4.2.1.1
type: Reaction
reversible: true
kinetic law: MODEL1310110063#
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 4.2.1.1 Confidence Level: 0 AUTHORS: PMID:10938543,PMID:11493685,PMID:12713833,PMID:12747791,PMID:14640555,PMID:17259996,PMID:17504134,PMID:17826101,PMID:7011879,PMID:7672338 NOTES:
fast: false

http://identifiers.org/biomodels.db/MODEL1310110063#_615f8124_427a_4f1e_8b7b_3e94c93711dc
has only substance units: false
initial concentration: NaN
initial amount: NaN
type: Species
is encoded by: hsa:93034
name: NT5C1B
constant: false
is: SBO:0000252
is: B3KUK6
boundary condition: true

metaR OCTAt
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:JLR
reversible: true
reactant: MODEL1310110063#
product: MODEL1310110063#
is described by: ECO:0000000
name: Octanoate transport via diffusion
fast: false
kinetic law: MODEL1310110063#
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110063#_f0d8252c_3d5f_4b4e_9020_23fb0c96d816
initial concentration: NaN
name: ACAA1:HSD17B4:ACOX1
type: Species
constant: false
has only substance units: false
has part: E9PB82
initial amount: NaN
is: SBO:0000297
is encoded by: hsa:3295
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110063#_167f40f2_cb7f_4277_bc9d_85b49cf85937
boundary condition: true
is: Q9BZX2
initial concentration: NaN
has only substance units: false
initial amount: NaN
name: UCK2
is: SBO:0000252
is encoded by: hsa:7371
constant: false
type: Species

metaM bhb c
type: Species
initial amount: NaN
has only substance units: false
is: HMDB00011
is: CHEBI:10983
initial concentration: 1.0
constant: false
notes: FORMULA: C4H7O3 CHARGE: -1 INCHI: InChI=1S/C4H8O3/c1-3(5)2-4(6)7/h3,5H,2H2,1H3,(H,6,7)/p-1/t3-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00661 EHMN_ABBREVIATION: C01089
is: SBO:0000247
name: (R)-3-hydroxybutyrate
boundary condition: false

metaR ST8SIA11
is: SBO:0000176
reversible: false
name: Beta-galactoside alpha-2,3-sialyltransferase
reactant: MODEL1310110063#
is version of: http://identifiers.org/ec-code/2.4.99.8
notes: GENE_ASSOCIATION: (6489.1) SUBSYSTEM: Sphingolipid metabolism EC Number: 2.4.99.8 Confidence Level: 4 AUTHORS: PMID:9199191 NOTES:NJ
fast: false
kinetic law: MODEL1310110063#
is described by: ECO:0000000
type: Reaction
product: MODEL1310110063#
modifier: MODEL1310110063#

metaM strdnccoa c
name: stearidonyl coenzyme A
initial concentration: 1.0
is: C16163
constant: false
is: HMDB06519
is: http://identifiers.org/pubchem.compound/47205473
boundary condition: false
has only substance units: false
is: SBO:0000247
initial amount: NaN
notes: FORMULA: C39H58N7O17P3S CHARGE: -4 INCHI: InChI=1/C39H62N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-30(48)67-23-22-41-29(47)20-21-42-37(51)34(50)39(2,3)25-60-66(57,58)63-65(55,56)59-24-28-33(62-64(52,53)54)32(49)38(61-28)46-27-45-31-35(40)43-26-44-36(31)46/h5-6,8-9,11-12,14-15,26-28,32-34,38,49-50H,4,7,10,13,16-25H2,1-3H3,(H,41,47)(H,42,51)(H,55,56)(H,57,58)(H2,40,43,44)(H2,52,53,54)/b6-5-,9-8-,12-11-,15-14-/t28-,32-,33?,34+,38-/m1/s1
type: Species

metaR r0688
kinetic law: MODEL1310110063#
modifier: MODEL1310110063#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.2.1.3
name: 3alpha,7alpha-Dihydroxy-5beta-cholestan-26-al:NAD+ oxidoreductase Bile acid biosynthesis EC:1.2.1.3
notes: GENE_ASSOCIATION: (AA081045.1) or (AI620219.1) or (219.1) or (217.1) or (224.1) or (501.1) or (223.1) or (AU149534.1) or (T83654.1) SUBSYSTEM: Bile acid synthesis EC Number: 1.2.1.3 Confidence Level: 0 AUTHORS: PMID:11182138,PMID:8155713,PMID:9538213 NOTES:
reactant: MODEL1310110063#
reversible: true
fast: false
product: MODEL1310110063#
is described by: ECO:0000000
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110063#_e6ca508f_9a02_4e6f_83d2_77b6deb9c2da
has only substance units: false
name: ALG2
initial amount: NaN
type: Species
boundary condition: true
constant: false
is encoded by: hsa:85365
initial concentration: NaN
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110063#_ee1ee6a7_914b_4c1a_afa6_e0ac3750fc04
initial amount: NaN
boundary condition: true
is: SBO:0000252
type: Species
is: Q53Y83
name: GLA
constant: false
initial concentration: NaN
is encoded by: hsa:2717
has only substance units: false

metaR SO4tl
is: SBO:0000185
fast: false
reactant: MODEL1310110063#
reversible: true
kinetic law: MODEL1310110063#
product: MODEL1310110063#
is described by: ECO:0000269
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 1 AUTHORS: PMID:10535998,PMID:15607730 NOTES:
name: Sulfate transport (lysosome)

http://identifiers.org/biomodels.db/MODEL1310110063#_06158cd4_708b_4cba_bb10_b1d9ea2577fa
is: SBO:0000252
boundary condition: true
name: ND3
initial amount: NaN
has only substance units: false
initial concentration: NaN
constant: false
is: P03897
is encoded by: hsa:4537
type: Species

http://identifiers.org/biomodels.db/MODEL1310110063#_41ae5647_9f2b_410f_ad0b_122b13bdbfb0
type: Species
name: NDUFA11:NDUFS7:ND1:ND2:ND3:ND4:ND4L:ND5:ND6:NDUFA1:NDUFA2:NDUFA3:NDUFA4:NDUFA5:NDUFA6:NDUFA7:NDUFA8:NDUFA9:NDUFA10:NDUFAB1:NDUFB1:NDUFB2:NDUFB3:NDUFB4:NDUFB5:NDUFB6:NDUFB7:NDUFB8:NDUFB9:NDUFB10:NDUFC1:NDUFC2:NDUFS1:NDUFS2:NDUFS3:NDUFV1:NDUFS4:NDUFS5:NDUFS6:NDUFS8:NDUFV2:NDUFV3:NDUFA13:NDUFA12:TUSC3
initial amount: NaN
is encoded by: hsa:4712
has part: Q5VYT2
initial concentration: NaN
is encoded by: hsa:4731
has only substance units: false
constant: false
boundary condition: true
is: SBO:0000297

metaM mev R x
initial concentration: 1.0
constant: false
is: HMDB00227
has only substance units: false
name: (R)-mevalonate
type: Species
notes: FORMULA: C6H11O4 CHARGE: -1 INCHI: InChI=1S/C6H12O4/c1-6(10,2-3-7)4-5(8)9/h7,10H,2-4H2,1H3,(H,8,9)/p-1/t6-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00343
boundary condition: false
is: SBO:0000247
initial amount: NaN
is: CHEBI:36464

metaR GGLUCT
modifier: MODEL1310110063#
fast: false
reversible: false
reactant: MODEL1310110063#
is described by: ECO:0000269
type: Reaction
notes: GENE_ASSOCIATION: (79017.1) SUBSYSTEM: Glutathione metabolism EC Number: 2.3.2.4 Confidence Level: 4 AUTHORS: PMID:2570694 NOTES:SAB
is version of: http://identifiers.org/ec-code/2.3.2.4
kinetic law: MODEL1310110063#
product: MODEL1310110063#
name: gamma-glutamylcyclotransferase
is: SBO:0000185

metaM dlnlcgcoa c
has only substance units: false
is: SBO:0000247
type: Species
is: CHEBI:27979
initial concentration: 1.0
initial amount: NaN
name: dihomo-gamma-linolenyl coenzyme A
notes: FORMULA: C41H64N7O17P3S CHARGE: -4 INCHI: InChI=1S/C41H68N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-32(50)69-25-24-43-31(49)22-23-44-39(53)36(52)41(2,3)27-62-68(59,60)65-67(57,58)61-26-30-35(64-66(54,55)56)34(51)40(63-30)48-29-47-33-37(42)45-28-46-38(33)48/h8-9,11-12,14-15,28-30,34-36,40,51-52H,4-7,10,13,16-27H2,1-3H3,(H,43,49)(H,44,53)(H,57,58)(H,59,60)(H2,42,45,46)(H2,54,55,56)/b9-8-,12-11-,15-14-/t30-,34-,35-,36+,40-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC02102
boundary condition: false
constant: false

metaM o2 r
boundary condition: false
name: O2
initial amount: NaN
is: CHEBI:15379
initial concentration: 1.0
is: HMDB01377
type: Species
constant: false
is: SBO:0000247
notes: FORMULA: O2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00017 EHMN_ABBREVIATION: C00007
is: C00007
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110063#_28d75be3_170b_4fc6_ab70_5ab7c25e3ed3
initial amount: NaN
is: SBO:0000252
type: Species
boundary condition: true
constant: false
is encoded by: hsa:1808
initial concentration: NaN
is: B4DR31
name: DPYSL2
has only substance units: false

metaM 5eipencoa m
constant: false
has only substance units: false
is: SBO:0000247
name: 5,8,11,14,17-eicosapentenoylcoa
type: Species
notes: FORMULA: C41H60N7O17P3S CHARGE: -4
initial concentration: 1.0
is: http://identifiers.org/pubchem.compound/24892790
boundary condition: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110063#_9916d7cc_7cec_4bd1_aa0f_dd167e39a84e
initial concentration: NaN
is: Q99808
initial amount: NaN
type: Species
is encoded by: hsa:2030
constant: false
name: SLC29A1
has only substance units: false
boundary condition: true
is: SBO:0000252

metaM 34dhoxpeg c
notes: FORMULA: C8H10O4 CHARGE: 0 INCHI: InChI=1/C8H10O4/c9-4-8(12)5-1-2-6(10)7(11)3-5/h1-3,8-12H,4H2 EHMN_ABBREVIATION: C05576
name: 3,4-Dihydroxyphenylethyleneglycol
is: HMDB00318
constant: false
initial concentration: 1.0
boundary condition: false
initial amount: NaN
is: SBO:0000247
has only substance units: false
is: http://identifiers.org/pubchem.compound/7902
type: Species
is: C05576

metaM ump g
constant: false
is: SBO:0000247
boundary condition: false
initial concentration: 1.0
has only substance units: false
is: CHEBI:57865
is: HMDB00288
type: Species
name: UMP(2-)
initial amount: NaN
notes: FORMULA: C9H11N2O9P CHARGE: -2 INCHI: InChI=1S/C9H13N2O9P/c12-5-1-2-11(9(15)10-5)8-7(14)6(13)4(20-8)3-19-21(16,17)18/h1-2,4,6-8,13-14H,3H2,(H,10,12,15)(H2,16,17,18)/p-2/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00105 EHMN_ABBREVIATION: C00105

metaR EX so4 LPAREN e RPAREN
kinetic law: MODEL1310110063#
reactant: MODEL1310110063#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Sulfate exchange
type: Reaction

metaR r2346
product: MODEL1310110063#
reactant: MODEL1310110063#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
is: SBO:0000185
kinetic law: MODEL1310110063#
type: Reaction
fast: false
is described by: ECO:0000000
name: Organic anion transporter 5 Utilized transport
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110063#_eeeee4db_5ee3_4cc6_a1d1_ed2a184d4046
type: Species
name: MIA3
is: SBO:0000252
has only substance units: false
is encoded by: hsa:375056
initial amount: NaN
initial concentration: NaN
is: Q5JRA6
boundary condition: true
constant: false

metaR MEVK1x
reversible: false
product: MODEL1310110063#
modifier: MODEL1310110063#
is version of: http://identifiers.org/ec-code/2.7.1.36
notes: GENE_ASSOCIATION: (4598.1) SUBSYSTEM: Cholesterol metabolism EC Number: 2.7.1.36 Confidence Level: 4 AUTHORS: PMID:11111079 NOTES:peroxisomal version NJ
name: mevalonate kinase (atp)
is described by: ECO:0000134
type: Reaction
is: SBO:0000176
reactant: MODEL1310110063#
fast: false
kinetic law: MODEL1310110063#

metaM dcmp c
notes: FORMULA: C9H12N3O7P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00217 EHMN_ABBREVIATION: C00239
is: SBO:0000247
is: C00239
initial concentration: 1.0
initial amount: NaN
has only substance units: false
boundary condition: false
name: dCMP
is: CHEBI:57566
type: Species
is: HMDB01202
constant: false

metaR r0686
is described by: ECO:0000000
type: Reaction
is version of: http://identifiers.org/ec-code/2.3.2.2
is: SBO:0000176
notes: GENE_ASSOCIATION: (AI222095.1) or (AI697028.1) or (D87002.1) or (2678.1) or (728441.1) or (2687.1) or (2686.1) or (728226.1) or (NM_013421.1) SUBSYSTEM: Arginine and Proline Metabolism EC Number: 1.5.1.12 Confidence Level: 0 AUTHORS: PMID:1286669,PMID:2211729 NOTES:
reversible: true
reactant: MODEL1310110063#
product: MODEL1310110063#
fast: false
kinetic law: MODEL1310110063#
modifier: MODEL1310110063#
name: L-1-Pyrroline-3-hydroxy-5-carboxylate:NADP+ oxidoreductase Arginine and proline metabolism EC:1.5.1.12

http://identifiers.org/biomodels.db/MODEL1310110063#_12ba747c_d90b_4acb_a331_45cab90b363e
initial amount: NaN
type: Species
is: SBO:0000252
is encoded by: hsa:5091
has only substance units: false
name: PC
boundary condition: true
constant: false
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110063#_e31fb4b6_49c7_4467_b978_29db25f1b9ae
type: Species
is: SBO:0000252
boundary condition: true
constant: false
name: PGM2
is encoded by: hsa:55276
is: Q96G03
initial concentration: NaN
has only substance units: false
initial amount: NaN

metaR RE0830N
reversible: true
reactant: MODEL1310110063#
is: SBO:0000176
notes: GENE_ASSOCIATION: (5092.1) or (84105.1) SUBSYSTEM: Tetrahydrobiopterin metabolism EC Number: 4.2.1.96 Confidence Level: 0 AUTHORS: PMID:10727395,PMID:1355046,PMID:1988938 NOTES:
is version of: http://identifiers.org/ec-code/4.2.1.96
product: MODEL1310110063#
modifier: MODEL1310110063#
name: RE0830
type: Reaction
fast: false
is described by: ECO:0000000
kinetic law: MODEL1310110063#

http://identifiers.org/biomodels.db/MODEL1310110063#_e7eaf0f7_acba_4f56_b6ee_e39f59546288
initial amount: NaN
is encoded by: hsa:471
boundary condition: true
type: Species
is: SBO:0000252
initial concentration: NaN
name: ATIC
constant: false
is: P31939
has only substance units: false

metaR EX malthp LPAREN e RPAREN
kinetic law: MODEL1310110063#
reactant: MODEL1310110063#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: maltoheptaose exchange
type: Reaction

metaR CYSTHRNaEx
modifier: MODEL1310110063#
is described by: ECO:0000269
name: L-cysteine/L-threonine Na-dependent exchange (Cys-L in)
type: Reaction
kinetic law: MODEL1310110063#
fast: false
reactant: MODEL1310110063#
is: SBO:0000185
reversible: false
product: MODEL1310110063#
notes: GENE_ASSOCIATION: (6509.1) or (6510.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14530974 NOTES:SAB see Kanai and Hediger 2004 (2003), PMID 14530974

http://identifiers.org/biomodels.db/MODEL1310110063#_61f43e4b_3b8b_47eb_b363_3e5e2cb5ba86
boundary condition: true
constant: false
initial concentration: NaN
name: SC5DL
has only substance units: false
type: Species
initial amount: NaN
is encoded by: hsa:6309
is: SBO:0000252
is: Q6GTM5

http://identifiers.org/biomodels.db/MODEL1310110063#_080d1062_46fc_45f3_aa9f_75c5f32b42cd
boundary condition: true
has part: B4E3E9
constant: false
is encoded by: hsa:4967
has only substance units: false
name: DLD:DLST:OGDH:PDHX
type: Species
initial concentration: NaN
initial amount: NaN
is: SBO:0000297

metaR r2347
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
name: Organic anion transporter 5 Utilized transport
kinetic law: MODEL1310110063#
product: MODEL1310110063#
type: Reaction
fast: false
is described by: ECO:0000000
reversible: true
reactant: MODEL1310110063#

http://identifiers.org/biomodels.db/MODEL1310110063#_ef30c8f6_71bb_4a6a_84f0_3d1033e19c1a
is: O94778
constant: false
is encoded by: hsa:343
boundary condition: true
is: SBO:0000252
initial concentration: NaN
name: AQP8
type: Species
has only substance units: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110063#_90824248_c000_4242_b85b_95b5a142d41b
is encoded by: hsa:1633
has only substance units: false
initial amount: NaN
name: DCK
constant: false
is: P27707
initial concentration: NaN
boundary condition: true
type: Species
is: SBO:0000252

metaM ametam c
is: SBO:0000247
is: C01137
type: Species
is: CHEBI:57443
is: HMDB00988
initial amount: NaN
constant: false
boundary condition: false
name: S-Adenosylmethioninamine
initial concentration: 1.0
notes: FORMULA: C14H24N6O3S CHARGE: 2 HEPATONET_1.0_ABBREVIATION: HC00683 EHMN_ABBREVIATION: C01137
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110063#_a68d44ea_6d29_46a8_8713_9d5d43d96d48
is: SBO:0000252
is: Q92820
has only substance units: false
initial amount: NaN
initial concentration: NaN
name: GGH
constant: false
type: Species
boundary condition: true
is encoded by: hsa:8836

http://identifiers.org/biomodels.db/MODEL1310110063#_dfb45545_c00e_4c79_8527_d32e4d21a027
initial amount: NaN
constant: false
is encoded by: hsa:AA203143
boundary condition: true
name: _AA203143_1_c
has only substance units: false
initial concentration: NaN
type: Species
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110063#_8d86ab02_8a27_4c6b_a704_49cdce0e119a
constant: false
initial amount: NaN
name: _LOC728997_1_c
boundary condition: true
has only substance units: false
type: Species
is encoded by: hsa:LOC728997
initial concentration: NaN
is: SBO:0000252

metaR 3HLYTCL
is described by: ECO:0000269
kinetic law: MODEL1310110063#
name: 3-Hydroxy-L-tyrosine carboxy-lyase
fast: false
is version of: http://identifiers.org/ec-code/4.1.1.28
modifier: MODEL1310110063#
type: Reaction
product: MODEL1310110063#
reactant: MODEL1310110063#
reversible: false
notes: GENE_ASSOCIATION: (1644.1) SUBSYSTEM: Tyrosine metabolism EC Number: 4.1.1.28 Confidence Level: 4 AUTHORS: NOTES:SAB
is: SBO:0000176

metaM ump e
name: UMP(2-)
initial concentration: 1.0
initial amount: NaN
notes: FORMULA: C9H11N2O9P CHARGE: -2 INCHI: InChI=1S/C9H13N2O9P/c12-5-1-2-11(9(15)10-5)8-7(14)6(13)4(20-8)3-19-21(16,17)18/h1-2,4,6-8,13-14H,3H2,(H,10,12,15)(H2,16,17,18)/p-2/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00105 EHMN_ABBREVIATION: C00105
type: Species
boundary condition: false
constant: false
has only substance units: false
is: HMDB00288
is: SBO:0000247
is: CHEBI:57865

metaR IDOURte
is described by: ECO:0000134
name: L-iduronate transport, extracellular
kinetic law: MODEL1310110063#
is: SBO:0000185
reversible: true
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
product: MODEL1310110063#
fast: false
reactant: MODEL1310110063#

metaM 34dhoxpeg e
is: HMDB00318
constant: false
notes: FORMULA: C8H10O4 CHARGE: 0 INCHI: InChI=1/C8H10O4/c9-4-8(12)5-1-2-6(10)7(11)3-5/h1-3,8-12H,4H2 EHMN_ABBREVIATION: C05576
initial concentration: 1.0
initial amount: NaN
name: 3,4-Dihydroxyphenylethyleneglycol
is: SBO:0000247
boundary condition: false
is: http://identifiers.org/pubchem.compound/7902
type: Species
has only substance units: false
is: C05576

metaM dhcrm hs c
name: dihydroceramide
initial amount: NaN
constant: false
type: Species
is: SBO:0000247
boundary condition: false
is: CHEBI:31488
initial concentration: 1.0
has only substance units: false
notes: FORMULA: C18H38NO2FULLRCO CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC02158 EHMN_ABBREVIATION: C12126

metaM o2 m
name: O2
is: HMDB01377
is: CHEBI:15379
is: C00007
has only substance units: false
constant: false
is: SBO:0000247
type: Species
initial concentration: 1.0
initial amount: NaN
boundary condition: false
notes: FORMULA: O2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00017 EHMN_ABBREVIATION: C00007

metaR MG3er
notes: GENE_ASSOCIATION: SUBSYSTEM: N-glycan synthesis EC Number: Confidence Level: 0 AUTHORS: NOTES:EC-3.2.1.- NCD
product: MODEL1310110063#
reversible: false
is: SBO:0000176
reactant: MODEL1310110063#
fast: false
type: Reaction
kinetic law: MODEL1310110063#
is described by: ECO:0000000
name: mannosyl-oligosaccharide glucosidase, endoplasmic reticulum

metaM g2m8masn r
has only substance units: false
is: SBO:0000247
initial concentration: 1.0
notes: FORMULA: C82H137N2O65X CHARGE: 0
initial amount: NaN
is: C05874
type: Species
boundary condition: false
name: (alpha-D-Glucosyl)2-(alpha-D-mannosyl)8-beta-D-mannosyl-diacetylchitobiosyl-L-asparagine (protein)
constant: false

metaM pail45p hs m
type: Species
initial amount: NaN
boundary condition: false
constant: false
initial concentration: 1.0
is: SBO:0000247
is: CHEBI:28910
name: phosphatidylinositol 4,5-bisphosphate
has only substance units: false
notes: FORMULA: C9H14O15P3FULLRCO2FULLR2CO2 CHARGE: -5 EHMN_ABBREVIATION: C04637

metaR GGH 6THFe
reactant: MODEL1310110063#
reversible: false
product: MODEL1310110063#
is described by: ECO:0000000
name: Gamma-glutamyl hydrolase (6THF), extracellular
is version of: http://identifiers.org/ec-code/3.4.19.9
notes: GENE_ASSOCIATION: (8836.1) SUBSYSTEM: Folate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:11375437,PMID:2867095,PMID:9614206 NOTES:REMOVES EITHER ONE OR TWO GLUTAMYL RESIDUES WITH A REACTION (WILL ONLY REPRESENT 1) IT
is: SBO:0000176
fast: false
modifier: MODEL1310110063#
kinetic law: MODEL1310110063#
type: Reaction

metaM HC00319 c
initial amount: NaN
constant: false
name: Malonate
initial concentration: 1.0
is: SBO:0000247
notes: FORMULA: C3H2O4 CHARGE: -2 INCHI: InChI=1S/C3H4O4/c4-2(5)1-3(6)7/h1H2,(H,4,5)(H,6,7)
is: CHEBI:30794
type: Species
has only substance units: false
boundary condition: false

metaR r2344
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
reactant: MODEL1310110063#
type: Reaction
is described by: ECO:0000000
kinetic law: MODEL1310110063#
fast: false
name: Organic anion transporter 5 Utilized transport
is: SBO:0000185
reversible: true
product: MODEL1310110063#

http://identifiers.org/biomodels.db/MODEL1310110063#_3dabdf13_09ed_4300_8e85_3037ad354a40
is encoded by: hsa:5330
constant: false
is: SBO:0000252
is: Q59F77
boundary condition: true
type: Species
has only substance units: false
initial concentration: NaN
initial amount: NaN
name: PLCB2

http://identifiers.org/biomodels.db/MODEL1310110063#_5dccac60_8694_40f9_86c0_7dfc1541a3db
type: Species
name: AMPD2
is: Q01433
initial amount: NaN
is: SBO:0000252
is encoded by: hsa:271
has only substance units: false
initial concentration: NaN
boundary condition: true
constant: false

metaM prostgh2 r
is: HMDB01381
has only substance units: false
boundary condition: false
notes: FORMULA: C20H31O5 CHARGE: -1 INCHI: InChI=1S/C20H32O5/c1-2-3-6-9-15(21)12-13-17-16(18-14-19(17)25-24-18)10-7-4-5-8-11-20(22)23/h4,7,12-13,15-19,21H,2-3,5-6,8-11,14H2,1H3,(H,22,23)/p-1/b7-4-,13-12+/t15-,16+,17+,18-,19+/m0/s1 EHMN_ABBREVIATION: C00427
initial concentration: 1.0
is: SBO:0000247
constant: false
type: Species
is: CHEBI:57405
name: prostaglandin H2(1-)
initial amount: NaN

metaR LINOFATPtc
kinetic law: MODEL1310110063#
product: MODEL1310110063#
reactant: MODEL1310110063#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: uptake of linoleic acid by the enterocytes
type: Reaction

metaM g2m8mpdol U r
has only substance units: false
type: Species
initial concentration: 1.0
initial amount: NaN
is: CHEBI:59093
is: SBO:0000247
boundary condition: false
name: (alpha-D-Glucosyl)2-(alpha-D-mannosyl)8-beta-D-mannosyl-diacetylchitobiosyldiphosphodolichol, human uterine homolog
constant: false
notes: FORMULA: C1845H3040N20O720P20 CHARGE: -20

metaM o2 n
name: dioxygen
boundary condition: false
has only substance units: false
constant: false
is: SBO:0000247
type: Species
notes: FORMULA: O2 CHARGE: 0 INCHI: InChI=1S/O2/c1-2 HEPATONET_1.0_ABBREVIATION: HC00017 EHMN_ABBREVIATION: C00007
is: HMDB01377
initial amount: NaN
is: CHEBI:15379
initial concentration: 1.0

metaR 4HPRO LTte
type: Reaction
kinetic law: MODEL1310110063#
product: MODEL1310110063#
fast: false
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
name: Transport of trans-4-hydroxy-L-proline
reactant: MODEL1310110063#
is: SBO:0000185
is described by: ECO:0000134

metaR r2014
reactant: MODEL1310110063#
is described by: ECO:0000000
modifier: MODEL1310110063#
type: Reaction
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.15
fast: false
reversible: false
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is: SBO:0000185
kinetic law: MODEL1310110063#
product: MODEL1310110063#

metaR r0683
product: MODEL1310110063#
kinetic law: MODEL1310110063#
modifier: MODEL1310110063#
reversible: false
is: SBO:0000176
notes: GENE_ASSOCIATION: (30.1) or (10449.1) or (3032.1) or (4645.1) SUBSYSTEM: Unassigned EC Number: 1.3.99.3 Confidence Level: 0 AUTHORS: PMID:10502673,PMID:3597357,PMID:4062874 NOTES:
is version of: http://identifiers.org/ec-code/2.3.1.16
name: Propanoyl-CoA:(acceptor) 2,3-oxidoreductase beta-Alanine metabolism EC:1.3.3.6 EC:1.3.99.3
fast: false
is described by: ECO:0000000
reactant: MODEL1310110063#
type: Reaction

metaM pail45p hs n
name: phosphatidylinositol 4,5-bisphosphate
notes: FORMULA: C9H14O15P3FULLRCO2FULLR2CO2 CHARGE: -5 EHMN_ABBREVIATION: C04637
constant: false
is: SBO:0000247
has only substance units: false
boundary condition: false
initial concentration: 1.0
type: Species
initial amount: NaN
is: CHEBI:28910

http://identifiers.org/biomodels.db/MODEL1310110063#_bd039200_c2f7_445b_8d48_14ab7d36a5d9
initial amount: NaN
name: ATP5H:ATP5L:NSF:ATP5F1:ATP5G3:ATP5I:ATP5J:ATP5J2
is: SBO:0000297
constant: false
boundary condition: true
initial concentration: NaN
is encoded by: hsa:518
type: Species
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110063#_2508d300_c8c4_4f84_abb0_29f091d68478
type: Species
initial concentration: NaN
initial amount: NaN
boundary condition: true
constant: false
is: SBO:0000252
has only substance units: false
name: _H77542_1_c
is encoded by: hsa:H77542

metaR FACOAL184
reactant: MODEL1310110063#
name: fatty-acid--CoA ligase
kinetic law: MODEL1310110063#
notes: GENE_ASSOCIATION: (2180.1) SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 4 AUTHORS: PMID:15292367 NOTES:NJ
is version of: http://identifiers.org/ec-code/6.2.1.3
type: Reaction
reversible: true
product: MODEL1310110063#
modifier: MODEL1310110063#
is described by: ECO:0000000
fast: false
is: SBO:0000176

metaM ttetddcoa m
is: HMDB02288
boundary condition: false
name: trans5,8tetradecadienoylcoa
initial concentration: 1.0
has only substance units: false
type: Species
is: SBO:0000247
constant: false
initial amount: NaN
notes: FORMULA: C35H54N7O17P3S CHARGE: -4

metaR r0033
reactant: MODEL1310110063#
modifier: MODEL1310110063#
is: SBO:0000176
name: ATP:dephospho-CoA 3-phosphotransferase Pantothenate and CoA biosynthesis EC:2.7.1.24
notes: GENE_ASSOCIATION: (AV717590.1) or (953.1) or (956.1) or (377841.1) SUBSYSTEM: CoA synthesis EC Number: 2.7.1.24 Confidence Level: 0 AUTHORS: PMID:11923312,PMID:11994049,PMID:13163064,PMID:15893380 NOTES:
kinetic law: MODEL1310110063#
fast: false
type: Reaction
product: MODEL1310110063#
reversible: false
is version of: http://identifiers.org/ec-code/3.6.1.5
is described by: ECO:0000000

metaM hdcoa c
name: Hexadecenoyl-CoA (n-C16:1CoA)
notes: FORMULA: C37H60N7O17P3S CHARGE: -4
initial amount: NaN
type: Species
is: SBO:0000247
constant: false
has only substance units: false
is: HMDB06532
initial concentration: 1.0
boundary condition: false

metaM hdca c
constant: false
is: SBO:0000247
type: Species
boundary condition: false
initial concentration: 1.0
notes: FORMULA: C16H31O2 CHARGE: -1 INCHI: InChI=1S/C16H32O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16(17)18/h2-15H2,1H3,(H,17,18)/p-1 HEPATONET_1.0_ABBREVIATION: HC00226 EHMN_ABBREVIATION: C00249
has only substance units: false
is: CHEBI:7896
name: palmitate
initial amount: NaN
is: HMDB00220

metaM 3octdectecoa x
initial amount: NaN
initial concentration: 1.0
boundary condition: false
is: SBO:0000247
type: Species
is: http://identifiers.org/pubchem.compound/5280355
notes: FORMULA: C39H58N7O17P3S CHARGE: -4
name: 3,6,9,12-octadecatetraenoylcoa
constant: false
has only substance units: false

metaM ump c
is: CHEBI:57865
boundary condition: false
initial amount: NaN
notes: FORMULA: C9H11N2O9P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00105 EHMN_ABBREVIATION: C00105
is: C00105
has only substance units: false
name: UMP
type: Species
is: HMDB00288
is: SBO:0000247
constant: false
initial concentration: 1.0

metaR MGCHrm
notes: GENE_ASSOCIATION: (549.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 4.2.1.18 Confidence Level: 4 AUTHORS: PMID:12434311,PMID:3082934 NOTES:MM
kinetic law: MODEL1310110063#
reversible: true
modifier: MODEL1310110063#
name: methylglutaconyl-CoA hydratase (reversible), mitochondrial
reactant: MODEL1310110063#
product: MODEL1310110063#
is version of: http://identifiers.org/ec-code/4.2.1.18
fast: false
type: Reaction
is described by: ECO:0000269
is: SBO:0000176

metaM m4mpdol U c
constant: false
type: Species
initial amount: NaN
notes: FORMULA: C1485H2440N20O420P20 CHARGE: -20 INCHI: InChI=1S/C71H122N2O42P2/c1-30(2)13-9-14-31(3)15-10-16-32(4)17-11-18-33(5)19-12-20-34(6)21-22-101-116(96,97)115-117(98,99)114-66-45(73-36(8)81)52(88)60(42(28-79)107-66)109-65-44(72-35(7)80)51(87)61(41(27-78)106-65)110-69-59(95)62(50(86)43(108-69)29-100-67-57(93)53(89)46(82)37(23-74)102-67)111-70-64(56(92)49(85)39(25-76)104-70)113-71-63(55(91)48(84)40(26-77)105-71)112-68-58(94)54(90)47(83)38(24-75)103-68/h13,15,17,19,34,37-71,74-79,82-95H,9-12,14,16,18,20-29H2,1-8H3,(H,72,80)(H,73,81)(H,96,97)(H,98,99)/b31-15+,32-17+,33-19+/t34?,37-,38-,39-,40-,41-,42-,43-,44-,45-,46-,47-,48-,49-,50-,51-,52-,53+,54+,55+,56+,57+,58+,59+,60-,61-,62+,63+,64+,65+,66-,67+,68-,69+,70-,71-/m1/s1
is: CHEBI:37633
boundary condition: false
is: SBO:0000247
has only substance units: false
initial concentration: 1.0
name: (alpha-D-Mannosyl)4-beta-D-mannosyl-diacetylchitobiosyldiphosphodolichol, human uterine homolog

metaM ala L m
name: L-alanine
boundary condition: false
constant: false
is: SBO:0000247
has only substance units: false
is: CHEBI:16977
initial amount: NaN
is: HMDB00161
type: Species
notes: FORMULA: C3H7NO2 CHARGE: 0 INCHI: InChI=1S/C3H7NO2/c1-2(4)3(5)6/h2H,4H2,1H3,(H,5,6)/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00048
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110063#_04326cc0_3c61_43ff_b3a4_9c2eb249ea53
constant: false
name: SLC25A1
is: SBO:0000252
boundary condition: true
is: D9HTE9
type: Species
has only substance units: false
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:6576

http://identifiers.org/biomodels.db/MODEL1310110063#_c38f7b01_52ba_4327_88e1_d2e3ecfe545b
boundary condition: true
has only substance units: false
is: Q6NVY1
initial concentration: NaN
constant: false
name: HIBCH
is encoded by: hsa:26275
initial amount: NaN
is: SBO:0000252
type: Species

metaM m5mpdol U r
is: SBO:0000247
type: Species
initial amount: NaN
notes: FORMULA: C1545H2540N20O470P20 CHARGE: -20
is: CHEBI:37634
has only substance units: false
name: (alpha-D-Mannosyl)5-beta-D-mannosyl-diacetylchitobiosyldiphosphodolichol, human uterine homolog
boundary condition: false
initial concentration: 1.0
constant: false

http://identifiers.org/biomodels.db/MODEL1310110063#_4f402b58_aa39_4203_b508_b99128125ec4
is encoded by: hsa:8760
is: O95674
type: Species
boundary condition: true
name: CDS2
constant: false
initial concentration: NaN
is: SBO:0000252
initial amount: NaN
has only substance units: false

metaM 3tetd7ecoacrn e
name: 3-hydroxy tetradecenoyl-7-carnitine
has only substance units: false
initial concentration: 1.0
is: SBO:0000247
constant: false
initial amount: NaN
boundary condition: false
type: Species
is: HMDB02014
notes: FORMULA: C21H39NO5 CHARGE: 0

http://identifiers.org/biomodels.db/MODEL1310110063#_c4aeedd8_f89d_4608_9f3e_ebf381c56c16
initial amount: NaN
is: SBO:0000252
is encoded by: hsa:220
is: P47895
constant: false
name: ALDH1A3
has only substance units: false
boundary condition: true
type: Species
initial concentration: NaN

metaM fum m
constant: false
is: HMDB00134
boundary condition: false
is: C00122
initial concentration: 1.0
initial amount: NaN
has only substance units: false
is: CHEBI:29806
type: Species
notes: FORMULA: C4H2O4 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00120 EHMN_ABBREVIATION: C00122
name: Fumarate
is: SBO:0000247

metaM paf hs e
constant: false
type: Species
is: CHEBI:36707
initial amount: NaN
has only substance units: false
name: 1-alkyl 2-acteylglycerol 3-phosphocholine
initial concentration: 1.0
is: SBO:0000247
notes: FORMULA: C11H23O4NPFULLRCO2 CHARGE: 0
boundary condition: false

metaR r2011
modifier: MODEL1310110063#
product: MODEL1310110063#
reactant: MODEL1310110063#
kinetic law: MODEL1310110063#
is described by: ECO:0000000
fast: false
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reversible: false
is: SBO:0000185
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.15
type: Reaction

metaR XOL7AONEtr
is described by: ECO:0000000
reactant: MODEL1310110063#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: PMID:12840657 NOTES:cholesterol precursor, transport by "diffusion" -> actually beleived to be flip-flop mechanism (PMID: 12840657). NJ
reversible: true
product: MODEL1310110063#
is: SBO:0000185
kinetic law: MODEL1310110063#
name: lipid, flip-flop intracellular transport
fast: false
type: Reaction

metaR RE1521M
product: MODEL1310110063#
fast: false
kinetic law: MODEL1310110063#
notes: GENE_ASSOCIATION: (1892.1) or (3030.1) or (1962.1) or (3032.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.17 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:7923814,PMID:9568246,PMID:9920399 NOTES:
modifier: MODEL1310110063#
is: SBO:0000176
type: Reaction
is version of: http://identifiers.org/ec-code/1.1.1.35
reversible: true
is version of: http://identifiers.org/ec-code/4.2.1.17
is described by: ECO:0000000
reactant: MODEL1310110063#
is version of: http://identifiers.org/ec-code/2.3.1.16
name: RE1521

metaR r1981
product: MODEL1310110063#
modifier: MODEL1310110063#
fast: false
name: Y+LAT2 Utilized transport
is described by: ECO:0000000
kinetic law: MODEL1310110063#
reactant: MODEL1310110063#
type: Reaction
is: SBO:0000185
reversible: false
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:

metaM pail hs n
is: CHEBI:57880
initial amount: NaN
is: SBO:0000247
initial concentration: 1.0
boundary condition: false
name: 1-phosphatidyl-1D-myo-inositol(1-)
has only substance units: false
notes: FORMULA: C9H16O9PFULLRCO2FULLR2CO2 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC02009 EHMN_ABBREVIATION: C01194
type: Species
constant: false

metaR RE2985X
kinetic law: MODEL1310110063#
name: RE2985
type: Reaction
notes: GENE_ASSOCIATION: (8310.1) or (8309.1) or (51.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.3.6 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:7775433 NOTES:
product: MODEL1310110063#
reactant: MODEL1310110063#
modifier: MODEL1310110063#
fast: false
is described by: ECO:0000000
reversible: false
is version of: http://identifiers.org/ec-code/1.3.3.6
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.17.99.3

metaM m5masnB2 g
constant: false
type: Species
is: SBO:0000247
initial amount: NaN
boundary condition: false
initial concentration: 1.0
name: (alpha-D-mannosyl)5-beta-D-mannosyl-diacetylchitobiosyl-L-asparagine (protein)
has only substance units: false
notes: FORMULA: C52H87N2O40X CHARGE: 0
is: HMDB00968
is: CHEBI:58282

metaM succ c
initial concentration: 1.0
has only substance units: false
notes: FORMULA: C4H4O4 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00049 EHMN_ABBREVIATION: C00042
name: Succinate
constant: false
type: Species
is: HMDB00254
boundary condition: false
initial amount: NaN
is: CHEBI:30031
is: SBO:0000247
is: C00042

http://identifiers.org/biomodels.db/MODEL1310110063#_bf5db1b8_5bdd_4cfd_bab1_6d75ee778e61
initial concentration: NaN
boundary condition: true
initial amount: NaN
has only substance units: false
is: F8VQS7
is encoded by: hsa:55967
is: SBO:0000252
name: NDUFA12
type: Species
constant: false

metaR ALCD21 D
is version of: http://identifiers.org/ec-code/1.1.99.24
reversible: false
fast: false
is described by: ECO:0000304
modifier: MODEL1310110063#
reactant: MODEL1310110063#
kinetic law: MODEL1310110063#
name: alcohol dehydrogenase (D-1,2-propanediol)
product: MODEL1310110063#
type: Reaction
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.1.1.1
notes: GENE_ASSOCIATION: (127.1) or (284273.2) or (125.1) or (128.1) or (131.1) or (125.1 and 124.1) or (124.1) or (130.1) or (137872.1) or (125.1 and 126.1) or (126.1 and 124.1) or (284273.1) or (126.1) SUBSYSTEM: Pyruvate metabolism EC Number: 1.1.1.1 Confidence Level: 2 AUTHORS: PMID:15987839,PMID:2296157 NOTES:NCD

metaM hdca e
is: C00249
has only substance units: false
constant: false
initial concentration: 1.0
is: SBO:0000247
is: CHEBI:0
type: Species
notes: FORMULA: C16H31O2 CHARGE: -1
initial amount: NaN
is: HMDB00220
name: Hexadecanoate (n-C16:0)
boundary condition: false

metaM mercppyr c
constant: false
is: CHEBI:57678
is: HMDB01368
is: SBO:0000247
has only substance units: false
type: Species
boundary condition: false
name: 3-mercaptopyruvate
notes: FORMULA: C3H3O3S CHARGE: -1 INCHI: InChI=1S/C3H4O3S/c4-2(1-7)3(5)6/h7H,1H2,(H,5,6)/p-1 HEPATONET_1.0_ABBREVIATION: HC00600 EHMN_ABBREVIATION: C00957
initial amount: NaN
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110063#_cfb52161_2946_4514_8d2d_540dffb29832
is: Q9P1E4
initial amount: NaN
initial concentration: NaN
is: SBO:0000252
type: Species
constant: false
boundary condition: true
name: MAN2A2
is encoded by: hsa:4122
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110063#_a9eb7ada_0791_4c35_97dc_84ff0abbfebc
constant: false
initial amount: NaN
type: Species
has only substance units: false
is: SBO:0000252
is: Q86SR1
boundary condition: true
initial concentration: NaN
name: GALNT10
is encoded by: hsa:55568

metaM nadp c
initial concentration: 1.0
has only substance units: false
notes: FORMULA: C21H25N7O17P3 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00016 EHMN_ABBREVIATION: C00006
is: SBO:0000247
constant: false
is: HMDB00217
name: Nicotinamide adenine dinucleotide phosphate
boundary condition: false
is: CHEBI:58349
type: Species
is: C00006
initial amount: NaN

metaR EX 3ivcrn
kinetic law: MODEL1310110063#
reactant: MODEL1310110063#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for 3-hydroxy-isovaleryl carnitine
type: Reaction

metaM ocdececrn m
is: HMDB06351
name: 11-octadecenoyl carnitine
type: Species
constant: false
is: SBO:0000247
initial amount: NaN
initial concentration: 1.0
has only substance units: false
boundary condition: false
notes: FORMULA: C25H47NO4 CHARGE: 0

http://identifiers.org/biomodels.db/MODEL1310110063#_12dc38f7_d308_4fdf_8c9c_ed04c03f7794
name: PCBD2
is: SBO:0000252
is encoded by: hsa:84105
boundary condition: true
type: Species
initial concentration: NaN
initial amount: NaN
is: Q9H0N5
has only substance units: false
constant: false

metaR FAOXC161C141m
kinetic law: MODEL1310110063#
product: MODEL1310110063#
reactant: MODEL1310110063#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C16:1-->C14:1)m
type: Reaction

metaM tetpent3coa c
name: tetracosapentaenoyl coenzyme A, n-3
boundary condition: false
type: Species
initial amount: NaN
constant: false
initial concentration: 1.0
is: C16167
notes: FORMULA: C45H68N7O17P3S CHARGE: -4 INCHI: InChI=1/C45H72N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-24-25-36(54)73-29-28-47-35(53)26-27-48-43(57)40(56)45(2,3)31-66-72(63,64)69-71(61,62)65-30-34-39(68-70(58,59)60)38(55)44(67-34)52-33-51-37-41(46)49-32-50-42(37)52/h5-6,8-9,11-12,14-15,17-18,32-34,38-40,44,55-56H,4,7,10,13,16,19-31H2,1-3H3,(H,47,53)(H,48,57)(H,61,62)(H,63,64)(H2,46,49,50)(H2,58,59,60)/b6-5-,9-8-,12-11-,15-14-,18-17-/t34-,38-,39-,40?,44-/m1/s1
has only substance units: false
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110063#_2a775700_95ef_47df_bfed_b3f3a5d4b88d
name: GLRX2
type: Species
initial concentration: NaN
initial amount: NaN
constant: false
is encoded by: hsa:51022
boundary condition: true
has only substance units: false
is: SBO:0000252

metaR r2353
reactant: MODEL1310110063#
is: SBO:0000185
name: Organic anion transporter 5 Utilized transport
product: MODEL1310110063#
kinetic law: MODEL1310110063#
is described by: ECO:0000000
fast: false
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
type: Reaction

metaR LNLNCACRNt
modifier: MODEL1310110063#
reactant: MODEL1310110063#
is described by: ECO:0000269
is: SBO:0000185
type: Reaction
kinetic law: MODEL1310110063#
notes: GENE_ASSOCIATION: (788.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: NOTES:NJ
name: transport into the mitochondria (carnitine)
fast: false
reversible: false
product: MODEL1310110063#

metaR C4x
kinetic law: MODEL1310110063#
product: MODEL1310110063#
reactant: MODEL1310110063#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: esterification of butyrylcoa to butyrylcarnitine for transport
type: Reaction

metaR ACOX22x
is described by: ECO:0000304
modifier: MODEL1310110063#
type: Reaction
fast: false
name: acyl-Coenzyme A oxidase 2, branched chain
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.17.99.3
reactant: MODEL1310110063#
product: MODEL1310110063#
kinetic law: MODEL1310110063#
notes: GENE_ASSOCIATION: (8309.1) SUBSYSTEM: Bile acid synthesis EC Number: 1.3.3.6 Confidence Level: 2 AUTHORS: PMID:11181649 NOTES:noted in uniprot to have FAD as cofactor - further reaction specific lit evidence not found to support or contradict, see Baumgart et al PNAS (1996) 93: 13748-13753 analog as per KEGG added NJ
reversible: false

metaR EX acnacngalgbside hs LPAREN e RPAREN
kinetic law: MODEL1310110063#
reactant: MODEL1310110063#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: disialyl galactosylgloboside (homo sapiens) exchange
type: Reaction

metaM prostgh2 e
name: prostaglandin H2(1-)
is: SBO:0000247
initial amount: NaN
is: HMDB01381
initial concentration: 1.0
notes: FORMULA: C20H31O5 CHARGE: -1 INCHI: InChI=1S/C20H32O5/c1-2-3-6-9-15(21)12-13-17-16(18-14-19(17)25-24-18)10-7-4-5-8-11-20(22)23/h4,7,12-13,15-19,21H,2-3,5-6,8-11,14H2,1H3,(H,22,23)/p-1/b7-4-,13-12+/t15-,16+,17+,18-,19+/m0/s1 EHMN_ABBREVIATION: C00427
constant: false
has only substance units: false
is: CHEBI:57405
boundary condition: false
type: Species

metaR 3DPHBH2
name: Hydroxylation of 3-Decaprenyl-4-hydroxybenzoate (NADPH)
type: Reaction
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Ubiquinone synthesis EC Number: Confidence Level: 2 AUTHORS: PMID:11051212 NOTES:Used to make Ubiquinone-10 enzyme has not been identified yet. IT
reactant: MODEL1310110063#
is described by: ECO:0000000
kinetic law: MODEL1310110063#
reversible: false
product: MODEL1310110063#
is: SBO:0000176

metaR DESAT20 2
product: MODEL1310110063#
name: fatty acyl-CoA desaturase (n-C20:4CoA -> n-C20:5CoA)
reversible: false
modifier: MODEL1310110063#
fast: false
reactant: MODEL1310110063#
is: SBO:0000176
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (3992.1) SUBSYSTEM: Fatty acid synthesis EC Number: 1.14.19.1 Confidence Level: 4 AUTHORS: NOTES:for homo sapiens, noted to actually be NADH-cyt b5, using NADH at present NJ
type: Reaction
kinetic law: MODEL1310110063#

metaR HSPASEly
is: SBO:0000176
is described by: ECO:0000000
reactant: MODEL1310110063#
reversible: false
type: Reaction
kinetic law: MODEL1310110063#
fast: false
name: heparan sulfate proteoglycan protease, lysosome (endosome)
notes: GENE_ASSOCIATION: SUBSYSTEM: Heparan sulfate degradation EC Number: Confidence Level: 2 AUTHORS: PMID:12782143,PMID:8993162 NOTES:Note that this reaction occurs in the endosome during endocytosis, but has been compartmentalized as lysosomal. NCD
product: MODEL1310110063#

http://identifiers.org/biomodels.db/MODEL1310110063#_f59dbebe_e634_4a68_8071_ab57fb75d6be
has only substance units: false
constant: false
is encoded by: hsa:10841
initial amount: NaN
boundary condition: true
name: FTCD
is: SBO:0000252
type: Species
is: O95954
initial concentration: NaN

metaR r2352
product: MODEL1310110063#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
type: Reaction
kinetic law: MODEL1310110063#
fast: false
reactant: MODEL1310110063#
is described by: ECO:0000000
is: SBO:0000185
name: Organic anion transporter 5 Utilized transport
reversible: true

metaR r1088
fast: false
reversible: true
reactant: MODEL1310110063#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:10049700,PMID:10574970,PMID:11389679,PMID:11557028,PMID:11564694,PMID:12824232,PMID:12930836,PMID:14574404,PMID:16288981,PMID:911815 NOTES:
product: MODEL1310110063#
is: SBO:0000185
name: Active transport
kinetic law: MODEL1310110063#
is described by: ECO:0000000

metaR DESAT22 1p
kinetic law: MODEL1310110063#
reactant: MODEL1310110063#
name: fatty acyl-CoA desaturase (n-C22:4CoA -> n-C22:5CoA)
reversible: false
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid synthesis EC Number: 1.14.19.1 Confidence Level: 4 AUTHORS: NOTES:
type: Reaction
product: MODEL1310110063#
fast: false
is described by: ECO:0000000

metaR NAIt
product: MODEL1310110063#
reversible: true
is: SBO:0000185
is described by: ECO:0000269
name: Na+ / iodide cotransport
reactant: MODEL1310110063#
fast: false
type: Reaction
notes: GENE_ASSOCIATION: (6528.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10893432,PMID:11034615,PMID:12679487,PMID:12748858,PMID:15546855,PMID:8559252,PMID:8806637,PMID:9341168 NOTES:NCD
kinetic law: MODEL1310110063#
modifier: MODEL1310110063#

metaM hs deg9 l
is: SBO:0000247
is: CHEBI:17115
has only substance units: false
initial amount: NaN
boundary condition: false
constant: false
initial concentration: 1.0
type: Species
name: heparan sulfate, degradation product 9
is: HMDB00187
notes: FORMULA: C61H87N3O76S8 CHARGE: -10

metaM xylt e
has only substance units: false
notes: FORMULA: C5H12O5 CHARGE: 0 INCHI: InChI=1S/C5H12O5/c6-1-3(8)5(10)4(9)2-7/h3-10H,1-2H2/t3-,4+,5+ HEPATONET_1.0_ABBREVIATION: HC00317 EHMN_ABBREVIATION: C00379
type: Species
name: xylitol
constant: false
initial amount: NaN
initial concentration: 1.0
is: CHEBI:17151
is: SBO:0000247
boundary condition: false
is: HMDB02917

metaM CE2420 m
constant: false
is: HMDB11123
has only substance units: false
is: CHEBI:28387
notes: FORMULA: C33H52N7O18P3S CHARGE: -4 INCHI: InChI=1/C33H56N7O18P3S/c1-4-5-6-7-8-9-10-11-21(41)16-24(43)62-15-14-35-23(42)12-13-36-31(46)28(45)33(2,3)18-55-61(52,53)58-60(50,51)54-17-22-27(57-59(47,48)49)26(44)32(56-22)40-20-39-25-29(34)37-19-38-30(25)40/h8-9,19-22,26-28,32,41,44-45H,4-7,10-18H2,1-3H3,(H,35,42)(H,36,46)(H,50,51)(H,52,53)(H2,34,37,38)(H2,47,48,49)/p-4/b9-8-/t21-,22-,26+,27+,28u,32-/m0/s1 EHMN_ABBREVIATION: CE2420
initial amount: NaN
name: (3S)-3-hydroxydodec-cis-6-enoyl-CoA
boundary condition: false
is: SBO:0000247
type: Species
initial concentration: 1.0

metaM dcsptn1coa x
is: HMDB06513
type: Species
notes: FORMULA: C43H64N7O17P3S CHARGE: -4 INCHI: InChI=1/C43H68N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-34(52)71-27-26-45-33(51)24-25-46-41(55)38(54)43(2,3)29-64-70(61,62)67-69(59,60)63-28-32-37(66-68(56,57)58)36(53)42(65-32)50-31-49-35-39(44)47-30-48-40(35)50/h8-9,11-12,14-15,17-18,20-21,30-32,36-38,42,53-54H,4-7,10,13,16,19,22-29H2,1-3H3,(H,45,51)(H,46,55)(H,59,60)(H,61,62)(H2,44,47,48)(H2,56,57,58)/b9-8-,12-11-,15-14-,18-17-,21-20-/t32-,36-,37?,38+,42-/m1/s1
initial concentration: 1.0
is: C16173
constant: false
boundary condition: false
has only substance units: false
name: docosa-4,7,10,13,16-pentaenoyl coenzyme A
is: http://identifiers.org/pubchem.compound/47205483
initial amount: NaN
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110063#_45656a41_4f9d_461b_ba1f_8849fb95d5bd
has only substance units: false
is: SBO:0000252
name: PEMT
constant: false
type: Species
initial amount: NaN
boundary condition: true
initial concentration: NaN
is encoded by: hsa:10400

metaR r2005
is described by: ECO:0000000
type: Reaction
reversible: false
reactant: MODEL1310110063#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.15
modifier: MODEL1310110063#
is: SBO:0000185
fast: false
kinetic law: MODEL1310110063#
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
product: MODEL1310110063#

metaR EX 3tetd7ecoacrn
kinetic law: MODEL1310110063#
reactant: MODEL1310110063#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for 3-hydroxy tetradecenoyl-7-carnitine
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110063#_11ec522a_d3c2_4b6e_a0b8_4fb8848e3da0
initial concentration: NaN
name: SLC7A8:SLC3A2
initial amount: NaN
type: Species
constant: false
has part: Q86U05
has only substance units: false
is: SBO:0000297
boundary condition: true
is encoded by: hsa:23428

http://identifiers.org/biomodels.db/MODEL1310110063#_f266315c_d190_48e1_a310_25591b03bcd0
initial amount: NaN
type: Species
initial concentration: NaN
name: B4GALT5
is: O43286
is encoded by: hsa:9334
boundary condition: true
has only substance units: false
constant: false
is: SBO:0000252

metaM 5thf e
type: Species
boundary condition: false
notes: FORMULA: C39H45N11O18 CHARGE: -6
has only substance units: false
is: HMDB06487
is: SBO:0000247
initial concentration: 1.0
name: pentaglutamyl folate (THF)
constant: false
initial amount: NaN

metaR C226COAtx
reversible: true
is described by: ECO:0000000
name: fatty acid intracellular transport
fast: false
kinetic law: MODEL1310110063#
product: MODEL1310110063#
reactant: MODEL1310110063#
type: Reaction
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: NOTES:interaction between peroxisomes and ER (some enzymes on the outer membrane) NJ

metaR CDSm
product: MODEL1310110063#
notes: GENE_ASSOCIATION: (8760.1) SUBSYSTEM: Glycerophospholipid metabolism EC Number: 2.7.7.41 Confidence Level: 4 AUTHORS: NOTES:inner mitochondrial membrane NJ
is: SBO:0000176
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/2.7.7.41
name: phosphatidate cytidylyltransferase
kinetic law: MODEL1310110063#
type: Reaction
reversible: false
fast: false
reactant: MODEL1310110063#
modifier: MODEL1310110063#

metaR PPCOACm
notes: GENE_ASSOCIATION: (5096.1 and 5095.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 6.4.1.3 Confidence Level: 4 AUTHORS: PMID:3460076,PMID:8188292 NOTES:TV
fast: false
name: Propionyl-CoA carboxylase, mitochondrial
is: SBO:0000176
is described by: ECO:0000269
reactant: MODEL1310110063#
modifier: MODEL1310110063#
is version of: http://identifiers.org/ec-code/6.4.1.3
kinetic law: MODEL1310110063#
product: MODEL1310110063#
reversible: false
type: Reaction

metaR O2t
reversible: true
fast: false
kinetic law: MODEL1310110063#
product: MODEL1310110063#
name: o2 transport (diffusion)
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 1 AUTHORS: NOTES:tv renamed from O2TP to O2t to avoid confusion with transport reaction from cytosol to peroxisome NCD
is: SBO:0000185
type: Reaction
is described by: ECO:0000000
reactant: MODEL1310110063#

metaR HAtly
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD
fast: false
name: hyaluronan transport, extracellular to lysosome
type: Reaction
product: MODEL1310110063#
reversible: false
is described by: ECO:0000000
reactant: MODEL1310110063#
is: SBO:0000185
kinetic law: MODEL1310110063#

http://identifiers.org/biomodels.db/MODEL1310110063#_1cd7e947_2b3f_4962_97e4_bf5f84714acb
boundary condition: true
type: Species
is: SBO:0000252
has only substance units: false
constant: false
initial concentration: NaN
is encoded by: hsa:517
initial amount: NaN
name: ATP5G2

metaR RETFAt
reactant: MODEL1310110063#
reversible: false
product: MODEL1310110063#
kinetic law: MODEL1310110063#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:1503811 NOTES:IT
is: SBO:0000185
is described by: ECO:0000000
type: Reaction
fast: false
name: fatty acid retinol efflux

metaM prostgh2 c
type: Species
constant: false
is: SBO:0000247
is: HMDB01381
initial amount: NaN
initial concentration: 1.0
has only substance units: false
notes: FORMULA: C20H31O5 CHARGE: -1 INCHI: InChI=1S/C20H32O5/c1-2-3-6-9-15(21)12-13-17-16(18-14-19(17)25-24-18)10-7-4-5-8-11-20(22)23/h4,7,12-13,15-19,21H,2-3,5-6,8-11,14H2,1H3,(H,22,23)/p-1/b7-4-,13-12+/t15-,16+,17+,18-,19+/m0/s1 EHMN_ABBREVIATION: C00427
name: prostaglandin H2(1-)
boundary condition: false
is: CHEBI:57405

metaM 5adtststerones e
initial concentration: 1.0
type: Species
has only substance units: false
initial amount: NaN
is: SBO:0000247
constant: false
name: 5alpha-Dihydrotestosterone sulfate
notes: FORMULA: C19H29O5S CHARGE: -1 INCHI: InChI=1/C19H30O5S/c1-18-9-7-13(20)11-12(18)3-4-14-15-5-6-17(24-25(21,22)23)19(15,2)10-8-16(14)18/h12,14-17H,3-11H2,1-2H3,(H,21,22,23)/t12-,14-,15-,16-,17-,18-,19-/m0/s1 EHMN_ABBREVIATION: CE6032
is: HMDB06278
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110063#_6c0324d7_84e2_417d_9157_2c64f3f656f3
has only substance units: false
boundary condition: true
name: NDUFA4L2
initial concentration: NaN
type: Species
constant: false
is encoded by: hsa:56901
is: SBO:0000252
initial amount: NaN
is: Q9NRX3

http://identifiers.org/biomodels.db/MODEL1310110063#_8f173ccc_3899_45dc_9a6f_a249d22abef7
initial amount: NaN
initial concentration: NaN
boundary condition: true
is: SBO:0000252
has only substance units: false
is encoded by: hsa:115286
constant: false
name: SLC25A26
type: Species
is: F8WAB8

http://identifiers.org/biomodels.db/MODEL1310110063#_04663e08_51f8_40cb_9041_f93ac0b13e28
is: Q16773
has only substance units: false
is: SBO:0000252
constant: false
is encoded by: hsa:883
boundary condition: true
initial amount: NaN
type: Species
initial concentration: NaN
name: CCBL1

metaM octd11ecoa m
is: SBO:0000247
initial amount: NaN
is: HMDB06294
initial concentration: 1.0
name: 11-octadecenoylcoa
notes: FORMULA: C39H64N7O17P3S CHARGE: -4
constant: false
has only substance units: false
boundary condition: false
type: Species

metaM nad m
constant: false
name: Nicotinamide adenine dinucleotide
has only substance units: false
type: Species
is: C00003
is: HMDB00902
boundary condition: false
is: SBO:0000247
initial amount: NaN
is: CHEBI:57540
initial concentration: 1.0
is: http://identifiers.org/pubchem.compound/3305

metaM HC02217 c
is: CHEBI:27647
name: prostaglandin-g2
has only substance units: false
boundary condition: false
constant: false
initial concentration: 1.0
type: Species
notes: FORMULA: C20H31O6 CHARGE: -1 INCHI: InChI=1S/C20H32O6/c1-2-3-6-9-15(24-23)12-13-17-16(18-14-19(17)26-25-18)10-7-4-5-8-11-20(21)22/h4,7,12-13,15-19,23H,2-3,5-6,8-11,14H2,1H3,(H,21,22)/b7-4-,13-12+/t15-,16+,17+,18-,19+/m0/s1 EHMN_ABBREVIATION: C05956
initial amount: NaN
is: SBO:0000247

metaR OROTGLUt
is: SBO:0000185
name: OROTGLUt
type: Reaction
is described by: ECO:0000134
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
reversible: true
fast: false
reactant: MODEL1310110063#
kinetic law: MODEL1310110063#
product: MODEL1310110063#

metaR FACOAL140i
is: SBO:0000176
product: MODEL1310110063#
fast: false
modifier: MODEL1310110063#
is described by: ECO:0000269
reversible: false
is version of: http://identifiers.org/ec-code/6.2.1.3
kinetic law: MODEL1310110063#
name: fatty-acid--CoA ligase (tetradecanoate)
reactant: MODEL1310110063#
type: Reaction
notes: GENE_ASSOCIATION: (2181.1) SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 4 AUTHORS: NOTES:JLR

http://identifiers.org/biomodels.db/MODEL1310110063#_7740d100_82c2_45ab_9840_649ed80d3805
type: Species
boundary condition: true
initial concentration: NaN
initial amount: NaN
constant: false
name: _AI640625_1_c
is: SBO:0000252
has only substance units: false
is encoded by: hsa:AI640625

metaM tym c
is: HMDB00306
has only substance units: false
is: CHEBI:327995
boundary condition: false
type: Species
initial concentration: 1.0
name: tyraminium
is: SBO:0000247
notes: FORMULA: C8H12NO CHARGE: 1 INCHI: InChI=1S/C8H11NO/c9-6-5-7-1-3-8(10)4-2-7/h1-4,10H,5-6,9H2/p+1 EHMN_ABBREVIATION: C00483
initial amount: NaN
constant: false

http://identifiers.org/biomodels.db/MODEL1310110063#_6237d414_98dc_430c_b8aa_ef41f803e5f5
has only substance units: false
boundary condition: true
constant: false
initial concentration: NaN
is encoded by: hsa:AV713053
initial amount: NaN
type: Species
is: SBO:0000252
name: _AV713053_1_m

metaM ksi deg4 l
is: SBO:0000247
notes: FORMULA: C222H355N15O197S12 CHARGE: -12
is: CHEBI:57737
is: HMDB00868
initial concentration: 1.0
type: Species
boundary condition: false
constant: false
name: keratan sulfate I, degradation product 4
initial amount: NaN
has only substance units: false

metaR CYTDK1
notes: GENE_ASSOCIATION: (7371.1) or (83549.1) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 2 AUTHORS: NOTES:
is version of: http://identifiers.org/ec-code/2.7.1.48
product: MODEL1310110063#
fast: false
is: SBO:0000176
name: ATPcytidine 5-phosphotransferase
reversible: false
kinetic law: MODEL1310110063#
modifier: MODEL1310110063#
type: Reaction
reactant: MODEL1310110063#
is described by: ECO:0000254

metaR DNDPt12m
notes: GENE_ASSOCIATION: (60386.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:11226231 NOTES:IT
modifier: MODEL1310110063#
reactant: MODEL1310110063#
kinetic law: MODEL1310110063#
type: Reaction
product: MODEL1310110063#
fast: false
reversible: false
is described by: ECO:0000269
name: dADP transport via ADP antiport
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110063#_ffcb67e7_539c_4d36_85f3_0d2ebb7369b0
is: P51160
initial concentration: NaN
is: SBO:0000252
constant: false
initial amount: NaN
is encoded by: hsa:5146
has only substance units: false
type: Species
boundary condition: true
name: PDE6C

metaM mev R c
initial amount: NaN
constant: false
notes: FORMULA: C6H11O4 CHARGE: -1 INCHI: InChI=1S/C6H12O4/c1-6(10,2-3-7)4-5(8)9/h7,10H,2-4H2,1H3,(H,8,9)/p-1/t6-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00343
type: Species
is: SBO:0000247
initial concentration: 1.0
is: CHEBI:36464
is: HMDB00227
name: (R)-mevalonate
boundary condition: false
has only substance units: false

metaR AKR1C1
product: MODEL1310110063#
reversible: false
modifier: MODEL1310110063#
is: SBO:0000176
name: aldo-keto reductase family 1, member C1 (chlordecone reductase; 3-alpha hydroxysteroid dehydrogenase, type I; dihydrodiol dehydrogenase 4)
kinetic law: MODEL1310110063#
type: Reaction
notes: GENE_ASSOCIATION: (1645.1) SUBSYSTEM: Steroid metabolism EC Number: 1.3.1.20 Confidence Level: 4 AUTHORS: PMID:8486699 NOTES:NJ
reactant: MODEL1310110063#
is described by: ECO:0000269
fast: false
is version of: http://identifiers.org/ec-code/1.3.1.20

http://identifiers.org/biomodels.db/MODEL1310110063#_1299c4d3_a586_4338_9fa2_1784457e618a
is: SBO:0000252
constant: false
name: PPCDC
initial amount: NaN
is encoded by: hsa:60490
type: Species
initial concentration: NaN
has only substance units: false
boundary condition: true
is: Q96CD2

metaR C4STMO2Pr
is version of: http://identifiers.org/ec-code/1.1.1.170
product: MODEL1310110063#
reversible: false
fast: false
is: SBO:0000176
notes: GENE_ASSOCIATION: (50814.1) SUBSYSTEM: Cholesterol metabolism EC Number: Confidence Level: 4 AUTHORS: NOTES:double check rxn specifics - see lit ref: Marijanovic, Molecular Endocrinology 2003 17:1715-1725 ER version NJ
is described by: ECO:0000000
reactant: MODEL1310110063#
modifier: MODEL1310110063#
kinetic law: MODEL1310110063#
type: Reaction
name: C-4 methyl sterol oxidase

metaR DALAt2r
kinetic law: MODEL1310110063#
notes: GENE_ASSOCIATION: (206358.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11390972,PMID:11959859 NOTES:JLR
product: MODEL1310110063#
type: Reaction
reactant: MODEL1310110063#
is: SBO:0000185
fast: false
reversible: true
modifier: MODEL1310110063#
is described by: ECO:0000304
name: D-alanine transport via proton symport

metaM pail hs c
initial concentration: 1.0
has only substance units: false
notes: FORMULA: C9H16O9PFULLRCO2FULLR2CO2 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC02009 EHMN_ABBREVIATION: C01194
name: 1-phosphatidyl-1D-myo-inositol(1-)
initial amount: NaN
constant: false
type: Species
is: CHEBI:57880
is: SBO:0000247
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110063#_618dcb07_90af_4bc5_a1a6_a237051eba85
is: SBO:0000252
has only substance units: false
is encoded by: hsa:AI631997
type: Species
constant: false
name: _AI631997_1_m
initial concentration: NaN
initial amount: NaN
boundary condition: true

metaR S6TASE15ly
is: SBO:0000176
fast: false
is version of: http://identifiers.org/ec-code/3.1.6.14
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (2799.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.1.6.14 Confidence Level: 4 AUTHORS: PMID:3196333,PMID:3689314,PMID:3689315 NOTES:NCD
name: N-acetylglucosamine-6-sulfatase, lysosomal
product: MODEL1310110063#
reversible: true
type: Reaction
reactant: MODEL1310110063#
kinetic law: MODEL1310110063#
modifier: MODEL1310110063#

metaR r1837
reactant: MODEL1310110063#
name: Y+LAT2 Utilized transport
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
type: Reaction
kinetic law: MODEL1310110063#
modifier: MODEL1310110063#
is: SBO:0000185
reversible: false
is described by: ECO:0000000
product: MODEL1310110063#
fast: false

http://identifiers.org/biomodels.db/MODEL1310110063#_3fdef5ff_d2ef_43a4_adea_473076af4f68
has only substance units: false
name: ATP1A4:ATP1B1
has part: Q13733
is: SBO:0000297
is encoded by: hsa:480
initial concentration: NaN
type: Species
boundary condition: true
initial amount: NaN
constant: false

metaR EX gtp LPAREN e RPAREN
kinetic law: MODEL1310110063#
reactant: MODEL1310110063#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: GTP exchange
type: Reaction

metaM 3mox4hoxm c
has only substance units: false
is: HMDB00291
constant: false
notes: FORMULA: C9H9O5 CHARGE: -1 INCHI: InChI=1S/C9H10O5/c1-14-7-4-5(2-3-6(7)10)8(11)9(12)13/h2-4,8,10-11H,1H3,(H,12,13)/p-1 HEPATONET_1.0_ABBREVIATION: HC01521 EHMN_ABBREVIATION: C05584
is: SBO:0000247
type: Species
initial concentration: 1.0
is: CHEBI:27622
initial amount: NaN
name: 3-Methoxy-4-hydroxymandelate
boundary condition: false

metaM dag hs r
notes: FORMULA: C3H6OFULLRCO2FULLR2CO2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC02055
name: diglyceride
is: CHEBI:18035
has only substance units: false
boundary condition: false
initial amount: NaN
is: SBO:0000247
constant: false
type: Species
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110063#_5e0a3115_2931_4d55_ac34_25696e63dc8b
is: SBO:0000252
initial concentration: NaN
has only substance units: false
initial amount: NaN
is: Q9H903
constant: false
is encoded by: hsa:441024
boundary condition: true
name: MTHFD2L
type: Species

metaM c226coa m
type: Species
initial amount: NaN
name: cervonyl coenzyme A
constant: false
has only substance units: false
notes: FORMULA: C43H62N7O17P3S CHARGE: -4 INCHI: InChI=1/C43H66N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-34(52)71-27-26-45-33(51)24-25-46-41(55)38(54)43(2,3)29-64-70(61,62)67-69(59,60)63-28-32-37(66-68(56,57)58)36(53)42(65-32)50-31-49-35-39(44)47-30-48-40(35)50/h5-6,8-9,11-12,14-15,17-18,20-21,30-32,36-38,42,53-54H,4,7,10,13,16,19,22-29H2,1-3H3,(H,45,51)(H,46,55)(H,59,60)(H,61,62)(H2,44,47,48)(H2,56,57,58)/b6-5-,9-8-,12-11-,15-14-,18-17-,21-20-/t32-,36-,37-,38?,42-/m1/s1
is: http://identifiers.org/pubchem.compound/47205479
initial concentration: 1.0
is: SBO:0000247
boundary condition: false
is: C16169

metaR EX ura LPAREN e RPAREN
kinetic law: MODEL1310110063#
reactant: MODEL1310110063#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Uracil exchange
type: Reaction

metaR RTOTAL3FATPc
kinetic law: MODEL1310110063#
product: MODEL1310110063#
reactant: MODEL1310110063#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: uptake of Rtotal3 by enterocytes
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110063#_2e0f2e38_5b64_4c62_96f8_daae0a37e3f7
has only substance units: false
type: Species
initial concentration: NaN
is encoded by: hsa:1892
is: SBO:0000252
initial amount: NaN
name: ECHS1
boundary condition: true
is: P30084
constant: false

http://identifiers.org/biomodels.db/MODEL1310110063#_e57f7061_6a05_47d1_86b2_eb791477badc
is: P35754
is encoded by: hsa:2745
constant: false
is: SBO:0000252
type: Species
initial amount: NaN
name: GLRX
has only substance units: false
initial concentration: NaN
boundary condition: true

metaR SCP22x
modifier: MODEL1310110063#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (6342.1) SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 4 AUTHORS: PMID:1703300 NOTES:intracellular transport, mechanism details not presently known NJ
name: Sterol carrier protein 2
kinetic law: MODEL1310110063#
is version of: http://identifiers.org/ec-code/2.3.1.176
reactant: MODEL1310110063#
is: SBO:0000185
fast: false
product: MODEL1310110063#
reversible: true
type: Reaction

metaR r0463
type: Reaction
product: MODEL1310110063#
is: SBO:0000176
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Cholesterol metabolism EC Number: 2.3.3.10 Confidence Level: 0 AUTHORS: PMID:11087424,PMID:11108725,PMID:1358203,PMID:7893153 NOTES:
name: (S)-3-Hydroxy-3-methylglutaryl-CoA acetoacetyl-CoA-lyase (CoA-acetylating) Synthesis and degradation of ketone bodies / Valine, leucine and isoleucine degradation / Butanoate metabolism EC:2.3.3.10
is described by: ECO:0000000
reactant: MODEL1310110063#
kinetic law: MODEL1310110063#
reversible: true

metaR r1836
is described by: ECO:0000000
kinetic law: MODEL1310110063#
reversible: false
is: SBO:0000185
fast: false
modifier: MODEL1310110063#
name: Y+LAT2 Utilized transport
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
type: Reaction
product: MODEL1310110063#
reactant: MODEL1310110063#

metaR DCSPTN1t
name: fatty acid transport via diffusion
product: MODEL1310110063#
reversible: true
is: SBO:0000185
fast: false
reactant: MODEL1310110063#
is described by: ECO:0000000
kinetic law: MODEL1310110063#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11788354,PMID:12864740 NOTES:NJ

metaR EX pyr LPAREN e RPAREN
kinetic law: MODEL1310110063#
reactant: MODEL1310110063#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Pyruvate exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110063#_327c0dc9_0276_4473_a734_e13b84560595
name: PDE6G
is: SBO:0000252
boundary condition: true
initial amount: NaN
constant: false
type: Species
initial concentration: NaN
is: P18545
has only substance units: false
is encoded by: hsa:5148

metaM inost c
is: HMDB00211
is: SBO:0000247
is: CHEBI:17268
boundary condition: false
has only substance units: false
constant: false
type: Species
name: myo-inositol
notes: FORMULA: C6H12O6 CHARGE: 0 INCHI: InChI=1S/C6H12O6/c7-1-2(8)4(10)6(12)5(11)3(1)9/h1-12H/t1-,2-,3-,4+,5-,6- HEPATONET_1.0_ABBREVIATION: HC00135 EHMN_ABBREVIATION: C00137
initial amount: NaN
initial concentration: 1.0

metaM pglyc hs c
constant: false
is: SBO:0000247
is: CHEBI:21338
initial concentration: 1.0
boundary condition: false
initial amount: NaN
has only substance units: false
type: Species
is: HMDB02704
notes: FORMULA: CHARGE: 0
name: pglyc_hs[c]

metaR S6TASE13ly
is: SBO:0000176
product: MODEL1310110063#
reversible: true
name: N-acetylglucosamine-6-sulfatase, lysosomal
fast: false
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (2799.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.1.6.14 Confidence Level: 4 AUTHORS: PMID:3196333,PMID:3689314,PMID:3689315 NOTES:NCD
is version of: http://identifiers.org/ec-code/3.1.6.14
kinetic law: MODEL1310110063#
type: Reaction
reactant: MODEL1310110063#
modifier: MODEL1310110063#

metaM ksii core4 pre5 g
has only substance units: false
notes: FORMULA: C69H112N6O48X CHARGE: -1
name: keratan sulfate II biosynthesis, precursor 5
initial amount: NaN
is: C00130
initial concentration: 1.0
is: HMDB00175
is: SBO:0000247
boundary condition: false
constant: false
is: CHEBI:58053
type: Species

metaR B MANNASEly
is described by: ECO:0000000
product: MODEL1310110063#
modifier: MODEL1310110063#
is: SBO:0000176
fast: false
reactant: MODEL1310110063#
is version of: http://identifiers.org/ec-code/3.2.1.25
type: Reaction
reversible: false
notes: GENE_ASSOCIATION: (4126.1) SUBSYSTEM: N-glycan degradation EC Number: 3.2.1.25 Confidence Level: 0 AUTHORS: PMID:9384606 NOTES:NCD
name: beta-mannosidase, lysosomal
kinetic law: MODEL1310110063#

metaR r0464
name: 4-Aminobutyraldehyde:NAD+ oxidoreductase Urea cycle and metabolism of amino groups EC:1.2.1.3
reversible: true
product: MODEL1310110063#
fast: false
type: Reaction
reactant: MODEL1310110063#
notes: GENE_ASSOCIATION: SUBSYSTEM: Glutamate metabolism EC Number: 1.2.1.3 Confidence Level: 0 AUTHORS: PMID:10467734,PMID:11790142,PMID:4817964,PMID:8155713,PMID:8645224,PMID:8786138 NOTES:
is: SBO:0000176
kinetic law: MODEL1310110063#
is described by: ECO:0000000

metaR PDX5PO
product: MODEL1310110063#
notes: GENE_ASSOCIATION: (55163.1) SUBSYSTEM: Vitamin B6 metabolism EC Number: 1.4.3.5 Confidence Level: 4 AUTHORS: PMID:15182361,PMID:6380540 NOTES:NCD
is version of: http://identifiers.org/ec-code/1.4.3.5
modifier: MODEL1310110063#
kinetic law: MODEL1310110063#
type: Reaction
reversible: true
fast: false
is: SBO:0000176
is described by: ECO:0000269
name: pyridoxine 5'-phosphate oxidase
reactant: MODEL1310110063#

metaR M1316Mg
modifier: MODEL1310110063#
fast: false
kinetic law: MODEL1310110063#
is: SBO:0000176
is described by: ECO:0000000
reactant: MODEL1310110063#
reversible: false
name: mannosyl-oligosaccharide 1,3-1,6-alpha-mannosidase
type: Reaction
is version of: http://identifiers.org/ec-code/3.2.1.114
product: MODEL1310110063#
notes: GENE_ASSOCIATION: (4124.1) or (4122.1) SUBSYSTEM: N-glycan synthesis EC Number: 3.2.1.114 Confidence Level: 0 AUTHORS: PMID:8524845 NOTES:NCD

metaR TXASr
product: MODEL1310110063#
name: Thromboxane-A synthase
reactant: MODEL1310110063#
is described by: ECO:0000134
reversible: false
type: Reaction
kinetic law: MODEL1310110063#
modifier: MODEL1310110063#
is version of: http://identifiers.org/ec-code/5.3.99.5
fast: false
notes: GENE_ASSOCIATION: (6916.1) SUBSYSTEM: Eicosanoid metabolism EC Number: 5.3.99.5 Confidence Level: 0 AUTHORS: PMID:10903770,PMID:2491846,PMID:7811713 NOTES:NJ
is: SBO:0000176

metaR DESAT20 1
reversible: false
fast: false
kinetic law: MODEL1310110063#
is: SBO:0000176
is described by: ECO:0000000
product: MODEL1310110063#
modifier: MODEL1310110063#
reactant: MODEL1310110063#
type: Reaction
notes: GENE_ASSOCIATION: (3992.1) SUBSYSTEM: Fatty acid synthesis EC Number: 1.14.19.1 Confidence Level: 4 AUTHORS: NOTES:for homo sapiens, noted to actually be NADH-cyt b5, using NADH at present NJ
name: fatty acyl-CoA desaturase (n-C20:3CoA -> n-C20:4CoA)

http://identifiers.org/biomodels.db/MODEL1310110063#_4c33f035_548c_43b5_84a2_10dbd630870b
constant: false
initial concentration: NaN
type: Species
name: GMPR2
has only substance units: false
is: SBO:0000252
boundary condition: true
is encoded by: hsa:51292
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110063#_ebe8766b_43b7_4f39_a217_17bb00a14ac2
constant: false
is: SBO:0000252
has only substance units: false
initial concentration: NaN
type: Species
is encoded by: hsa:55825
is: Q9BY49
name: PECR
initial amount: NaN
boundary condition: true

metaM CE2421 m
is: SBO:0000247
name: (3S)-3-hydroxylinoleoyl-CoA
is: CHEBI:30623
type: Species
initial concentration: 1.0
constant: false
notes: FORMULA: C39H62N7O18P3S CHARGE: -4 INCHI: InChI=1/C39H66N7O18P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-27(47)22-30(49)68-21-20-41-29(48)18-19-42-37(52)34(51)39(2,3)24-61-67(58,59)64-66(56,57)60-23-28-33(63-65(53,54)55)32(50)38(62-28)46-26-45-31-35(40)43-25-44-36(31)46/h8-9,11-12,25-28,32-34,38,47,50-51H,4-7,10,13-24H2,1-3H3,(H,41,48)(H,42,52)(H,56,57)(H,58,59)(H2,40,43,44)(H2,53,54,55)/p-4/b9-8-,12-11-/t27-,28-,32+,33+,34u,38-/m0/s1 EHMN_ABBREVIATION: CE2421
is: HMDB02329
initial amount: NaN
boundary condition: false
has only substance units: false

metaM mi13p c
type: Species
initial amount: NaN
is: CHEBI:18225
initial concentration: 1.0
constant: false
name: 1D-myo-Inositol 1,3-bisphosphate
notes: FORMULA: C6H10O12P2 CHARGE: -4 INCHI: InChI=1S/C6H14O12P2/c7-1-2(8)5(17-19(11,12)13)4(10)6(3(1)9)18-20(14,15)16/h1-10H,(H2,11,12,13)(H2,14,15,16)/t1-,2-,3+,4+,5+,6-
has only substance units: false
is: SBO:0000247
is: HMDB06234
boundary condition: false

metaM c51crn e
is: HMDB02366
initial amount: NaN
constant: false
initial concentration: 1.0
boundary condition: false
name: tiglyl carnitine
has only substance units: false
type: Species
notes: FORMULA: C12H21NO4 CHARGE: 0
is: SBO:0000247

metaR r1638
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
fast: false
modifier: MODEL1310110063#
is: SBO:0000185
product: MODEL1310110063#
is described by: ECO:0000000
reversible: true
type: Reaction
reactant: MODEL1310110063#
kinetic law: MODEL1310110063#
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:

metaM nadp m
has only substance units: false
is: C00006
notes: FORMULA: C21H25N7O17P3 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00016 EHMN_ABBREVIATION: C00006
constant: false
initial concentration: 1.0
initial amount: NaN
is: HMDB00217
is: CHEBI:58349
boundary condition: false
name: Nicotinamide adenine dinucleotide phosphate
type: Species
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110063#_85f80834_c438_4f1b_ba24_95471239d112
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:5152
has only substance units: false
type: Species
name: PDE9A
initial amount: NaN
boundary condition: true
constant: false

metaM 4hbzcoa m
notes: FORMULA: C28H36N7O18P3S CHARGE: -4 INCHI: InChI=1/C28H40N7O18P3S/c1-28(2,22(39)25(40)31-8-7-18(37)30-9-10-57-27(41)15-3-5-16(36)6-4-15)12-50-56(47,48)53-55(45,46)49-11-17-21(52-54(42,43)44)20(38)26(51-17)35-14-34-19-23(29)32-13-33-24(19)35/h3-6,13-14,17,20-22,26,36,38-39H,7-12H2,1-2H3,(H,30,37)(H,31,40)(H,45,46)(H,47,48)(H2,29,32,33)(H2,42,43,44)/t17-,20?,21-,22+,26-/m1/s1
boundary condition: false
has only substance units: false
name: 4-hydroxybenoyl-CoA
type: Species
is: HMDB06467
is: SBO:0000247
constant: false
initial amount: NaN
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110063#_a81e19a0_ee4f_460c_872d_4924889fe63a
type: Species
has part: Q6NZ59
name: ATP5H:ATP5L:NSF:ATP5F1:ATP5G1:ATP5I:ATP5J:ATP5J2
has only substance units: false
is: SBO:0000297
is encoded by: hsa:522
initial amount: NaN
initial concentration: NaN
boundary condition: true
constant: false

metaR EX c16dc
kinetic law: MODEL1310110063#
reactant: MODEL1310110063#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for Hexadecanedioic acid mono-L-carnitine ester
type: Reaction

metaM pro D e
initial concentration: 1.0
has only substance units: false
is: CHEBI:16313
notes: FORMULA: C5H9NO2 CHARGE: 0 INCHI: InChI=1S/C5H9NO2/c7-5(8)4-2-1-3-6-4/h4,6H,1-3H2,(H,7,8)/t4-/m1/s1
is: HMDB03411
is: SBO:0000247
type: Species
name: D-proline
boundary condition: false
constant: false
initial amount: NaN

metaR INSTt2r
fast: false
is described by: ECO:0000269
modifier: MODEL1310110063#
reversible: true
name: inositol transport in via proton symport
product: MODEL1310110063#
is: SBO:0000185
type: Reaction
kinetic law: MODEL1310110063#
notes: GENE_ASSOCIATION: (114134.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:11500374,PMID:12750891 NOTES:
reactant: MODEL1310110063#

http://identifiers.org/biomodels.db/MODEL1310110063#_ac86fe42_d971_409b_99e1_373e646cc726
is: SBO:0000252
type: Species
is encoded by: hsa:6342
constant: false
is: C9JC79
initial amount: NaN
initial concentration: NaN
name: SCP2
has only substance units: false
boundary condition: true

metaM doco13ecoa x
boundary condition: false
initial amount: NaN
is: http://identifiers.org/pubchem.compound/24892791
constant: false
has only substance units: false
notes: FORMULA: C43H72N7O17P3S CHARGE: -4
initial concentration: 1.0
type: Species
name: 13-docosenoylcoa
is: SBO:0000247

metaM 13 cis retn r
notes: FORMULA: C20H27O2 CHARGE: -1 INCHI: InChI=1/C20H28O2/c1-15(8-6-9-16(2)14-19(21)22)11-12-18-17(3)10-7-13-20(18,4)5/h6,8-9,11-12,14H,7,10,13H2,1-5H3,(H,21,22)/b9-6+,12-11+,15-8+,16-14- EHMN_ABBREVIATION: CE2952
type: Species
is: D00348
has only substance units: false
is: http://identifiers.org/pubchem.compound/7847414
initial amount: NaN
name: 13-cis-retinoate
is: SBO:0000247
initial concentration: 1.0
is: HMDB06219
constant: false
boundary condition: false

metaM ala L c
initial concentration: 1.0
is: CHEBI:16977
boundary condition: false
name: L-alanine
constant: false
notes: FORMULA: C3H7NO2 CHARGE: 0 INCHI: InChI=1S/C3H7NO2/c1-2(4)3(5)6/h2H,4H2,1H3,(H,5,6)/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00048
initial amount: NaN
has only substance units: false
is: HMDB00161
is: SBO:0000247
type: Species

http://identifiers.org/biomodels.db/MODEL1310110063#_f633b437_37a5_464c_9951_1722b13f057c
boundary condition: true
is encoded by: hsa:6526
is: SBO:0000252
initial amount: NaN
has only substance units: false
is: P53794
type: Species
constant: false
initial concentration: NaN
name: SLC5A3

metaR SEBCOACROT
kinetic law: MODEL1310110063#
product: MODEL1310110063#
reactant: MODEL1310110063#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: production of sebacoyl carnitine
type: Reaction

metaR r1637
kinetic law: MODEL1310110063#
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reversible: true
reactant: MODEL1310110063#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is described by: ECO:0000000
fast: false
type: Reaction
product: MODEL1310110063#
is: SBO:0000185
modifier: MODEL1310110063#

metaM nicrns c
is: HMDB06809
name: Nicotinate D-ribonucleoside
constant: false
initial amount: NaN
type: Species
is: SBO:0000247
boundary condition: false
has only substance units: false
initial concentration: 1.0
is: CHEBI:58527
notes: FORMULA: C11H13NO6 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC01628 EHMN_ABBREVIATION: C05841

metaM 3mgcoa m
name: trans-3-methylglutaconyl-CoA(5-)
constant: false
notes: FORMULA: C27H37N7O19P3S CHARGE: -5 INCHI: InChI=1S/C27H42N7O19P3S/c1-14(8-17(36)37)9-18(38)57-7-6-29-16(35)4-5-30-25(41)22(40)27(2,3)11-50-56(47,48)53-55(45,46)49-10-15-21(52-54(42,43)44)20(39)26(51-15)34-13-33-19-23(28)31-12-32-24(19)34/h8,12-13,15,20-22,26,39-40H,4-7,9-11H2,1-3H3,(H,29,35)(H,30,41)(H,36,37)(H,45,46)(H,47,48)(H2,28,31,32)(H2,42,43,44)/p-5/b14-8+/t15-,20-,21-,22+,26-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01081 EHMN_ABBREVIATION: C03231
is: HMDB01057
boundary condition: false
initial amount: NaN
type: Species
is: CHEBI:57346
initial concentration: 1.0
has only substance units: false
is: SBO:0000247

metaM nad x
initial amount: NaN
type: Species
is: C00003
name: Nicotinamide adenine dinucleotide
initial concentration: 1.0
has only substance units: false
is: HMDB00902
is: SBO:0000247
is: CHEBI:57540
boundary condition: false
constant: false
is: http://identifiers.org/pubchem.compound/3305

metaM ddece1crn e
initial amount: NaN
name: dodecenoyl carnitine
boundary condition: false
type: Species
has only substance units: false
is: HMDB02250
initial concentration: 1.0
notes: FORMULA: C19H35NO4 CHARGE: 0
constant: false
is: SBO:0000247

metaM inost e
initial concentration: 1.0
initial amount: NaN
boundary condition: false
has only substance units: false
is: CHEBI:17268
name: myo-inositol
is: HMDB00211
notes: FORMULA: C6H12O6 CHARGE: 0 INCHI: InChI=1S/C6H12O6/c7-1-2(8)4(10)6(12)5(11)3(1)9/h1-12H/t1-,2-,3-,4+,5-,6- HEPATONET_1.0_ABBREVIATION: HC00135 EHMN_ABBREVIATION: C00137
type: Species
is: SBO:0000247
constant: false

metaR FAOXTC122TC101m
kinetic law: MODEL1310110063#
product: MODEL1310110063#
reactant: MODEL1310110063#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation trans(C12:2-->C10:1)m
type: Reaction

metaR DOLPMT3 Uer
type: Reaction
name: dolichyl-phosphate-mannose-glycolipid alpha-mannosyltransferase (uterus)
modifier: MODEL1310110063#
fast: false
reversible: false
is version of: http://identifiers.org/ec-code/2.4.1.260
product: MODEL1310110063#
notes: GENE_ASSOCIATION: (79087.1) SUBSYSTEM: N-glycan synthesis EC Number: 2.4.1.130 Confidence Level: 0 AUTHORS: NOTES:NCD
is described by: ECO:0000000
is: SBO:0000176
kinetic law: MODEL1310110063#
reactant: MODEL1310110063#

http://identifiers.org/biomodels.db/MODEL1310110063#_b6194c13_e262_4f8a_8434_b80bb6e13323
is encoded by: hsa:AI435857
is: SBO:0000252
initial amount: NaN
name: _AI435857_1_x
constant: false
has only substance units: false
boundary condition: true
type: Species
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110063#_e20e29ef_777a_4939_b7ee_68b0c8fe1952
initial concentration: NaN
is: Q5JAM2
constant: false
type: Species
boundary condition: true
is: SBO:0000252
has only substance units: false
name: ALAS1
initial amount: NaN
is encoded by: hsa:211

metaR C10OHc
kinetic law: MODEL1310110063#
product: MODEL1310110063#
reactant: MODEL1310110063#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: production of 3-OHdecanoylcarnitinec
type: Reaction

metaM octd11ecoa c
name: 11-octadecenoylcoa
initial amount: NaN
notes: FORMULA: C39H64N7O17P3S CHARGE: -4
has only substance units: false
is: http://identifiers.org/pubchem.compound/5280771
is: SBO:0000247
constant: false
boundary condition: false
initial concentration: 1.0
type: Species

http://identifiers.org/biomodels.db/MODEL1310110063#_4d3512c4_a475_4f53_b0fb_f1ef2ec204de
initial amount: NaN
is: SBO:0000252
type: Species
is encoded by: hsa:5296
constant: false
boundary condition: true
has only substance units: false
is: O00459
initial concentration: NaN
name: PIK3R2

http://identifiers.org/biomodels.db/MODEL1310110063#_a0f7ce00_78ad_4e6e_8a5e_b504a7a69416
is: C9JPQ8
is: SBO:0000252
type: Species
initial concentration: NaN
is encoded by: hsa:5095
initial amount: NaN
constant: false
has only substance units: false
name: PCCA
boundary condition: true

metaM creat c
is: SBO:0000247
is: HMDB00064
boundary condition: false
is: CHEBI:16919
initial concentration: 1.0
has only substance units: false
initial amount: NaN
name: creatine
constant: false
type: Species
notes: FORMULA: C4H9N3O2 CHARGE: 0 INCHI: InChI=1S/C4H9N3O2/c1-7(4(5)6)2-3(8)9/h2H2,1H3,(H3,5,6)(H,8,9) HEPATONET_1.0_ABBREVIATION: HC00260 EHMN_ABBREVIATION: C00300

metaM c51crn c
is: SBO:0000247
initial amount: NaN
is: HMDB02366
initial concentration: 1.0
name: tiglyl carnitine
has only substance units: false
boundary condition: false
constant: false
notes: FORMULA: C12H21NO4 CHARGE: 0
type: Species

metaR NRPPHRtu
reactant: MODEL1310110063#
notes: GENE_ASSOCIATION: (6581.1) or (6582.2) or (6582.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12883891 NOTES:SAB electrogenic, Na indepdendent & rev NJ
is: SBO:0000185
is described by: ECO:0000269
modifier: MODEL1310110063#
fast: false
kinetic law: MODEL1310110063#
type: Reaction
name: Norepinephrine uniport
reversible: true
product: MODEL1310110063#

metaM pro D c
is: SBO:0000247
is: CHEBI:16313
type: Species
boundary condition: false
has only substance units: false
is: HMDB03411
constant: false
notes: FORMULA: C5H9NO2 CHARGE: 0 INCHI: InChI=1S/C5H9NO2/c7-5(8)4-2-1-3-6-4/h4,6H,1-3H2,(H,7,8)/t4-/m1/s1
initial concentration: 1.0
name: D-proline
initial amount: NaN

metaM 34hpl m
initial amount: NaN
constant: false
has only substance units: false
is: HMDB00755
name: 3-(4-hydroxyphenyl)lactate
type: Species
is: CHEBI:36659
initial concentration: 1.0
notes: FORMULA: C9H9O4 CHARGE: -1 INCHI: InChI=1S/C9H10O4/c10-7-3-1-6(2-4-7)5-8(11)9(12)13/h1-4,8,10-11H,5H2,(H,12,13)/p-1
is: SBO:0000247
boundary condition: false

metaM dd2coa x
initial concentration: 1.0
boundary condition: false
name: trans-Dodec-2-enoyl-CoA
type: Species
constant: false
notes: FORMULA: C33H52N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC01078 EHMN_ABBREVIATION: C03221
is: HMDB03712
is: SBO:0000247
initial amount: NaN
has only substance units: false
is: CHEBI:57330

metaM pail45p hs c
constant: false
notes: FORMULA: C9H14O15P3FULLRCO2FULLR2CO2 CHARGE: -5 EHMN_ABBREVIATION: C04637
is: CHEBI:28910
has only substance units: false
is: SBO:0000247
boundary condition: false
type: Species
name: phosphatidylinositol 4,5-bisphosphate
initial amount: NaN
initial concentration: 1.0

metaM dcsptn1coa m
initial amount: NaN
constant: false
initial concentration: 1.0
notes: FORMULA: C43H64N7O17P3S CHARGE: -4 INCHI: InChI=1/C43H68N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-34(52)71-27-26-45-33(51)24-25-46-41(55)38(54)43(2,3)29-64-70(61,62)67-69(59,60)63-28-32-37(66-68(56,57)58)36(53)42(65-32)50-31-49-35-39(44)47-30-48-40(35)50/h8-9,11-12,14-15,17-18,20-21,30-32,36-38,42,53-54H,4-7,10,13,16,19,22-29H2,1-3H3,(H,45,51)(H,46,55)(H,59,60)(H,61,62)(H2,44,47,48)(H2,56,57,58)/b9-8-,12-11-,15-14-,18-17-,21-20-/t32-,36-,37?,38+,42-/m1/s1
is: SBO:0000247
is: C16173
name: docosa-4,7,10,13,16-pentaenoyl coenzyme A
is: HMDB06513
boundary condition: false
type: Species
is: http://identifiers.org/pubchem.compound/47205483
has only substance units: false

metaM HC02217 e
boundary condition: false
notes: FORMULA: C20H31O6 CHARGE: -1 INCHI: InChI=1S/C20H32O6/c1-2-3-6-9-15(24-23)12-13-17-16(18-14-19(17)26-25-18)10-7-4-5-8-11-20(21)22/h4,7,12-13,15-19,23H,2-3,5-6,8-11,14H2,1H3,(H,21,22)/b7-4-,13-12+/t15-,16+,17+,18-,19+/m0/s1 EHMN_ABBREVIATION: C05956
initial amount: NaN
has only substance units: false
is: CHEBI:27647
is: SBO:0000247
constant: false
initial concentration: 1.0
type: Species
name: prostaglandin-g2

metaR PCHOLP hs
kinetic law: MODEL1310110063#
is: SBO:0000176
modifier: MODEL1310110063#
name: choline phosphatase
is version of: http://identifiers.org/ec-code/3.1.4.4
fast: false
notes: GENE_ASSOCIATION: (5338.1) SUBSYSTEM: Glycerophospholipid metabolism EC Number: 3.1.4.4 Confidence Level: 4 AUTHORS: PMID:9395408,PMID:9582313 NOTES:NJ
is described by: ECO:0000269
type: Reaction
product: MODEL1310110063#
reactant: MODEL1310110063#
reversible: false

metaR DNDPt23m
type: Reaction
is: SBO:0000185
reversible: false
is described by: ECO:0000269
fast: false
reactant: MODEL1310110063#
name: dTDP transport via dGTP antiport
kinetic law: MODEL1310110063#
notes: GENE_ASSOCIATION: (60386.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:11226231 NOTES:IT
modifier: MODEL1310110063#
product: MODEL1310110063#

metaM 2hexdtricoa m
boundary condition: false
type: Species
initial amount: NaN
name: 2,7,10-hexadecatrienoylcoa
is: SBO:0000247
constant: false
initial concentration: 1.0
notes: FORMULA: C37H56N7O17P3S CHARGE: -4
has only substance units: false
is: HMDB02288

http://identifiers.org/biomodels.db/MODEL1310110063#_8f6b92c0_fcf6_4b2d_bae4_9da3aed11ef3
type: Species
is: SBO:0000252
name: NDUFB2
is: H7C5B8
initial concentration: NaN
initial amount: NaN
constant: false
is encoded by: hsa:4708
has only substance units: false
boundary condition: true

metaM Ser Thr g
constant: false
initial concentration: 1.0
name: protein-linked serine or threonine residue (O-glycosylation site)
type: Species
notes: FORMULA: XH CHARGE: 0
is: SBO:0000247
is: CHEBI:58336
has only substance units: false
boundary condition: false
initial amount: NaN
is: HMDB00645

metaR r1639
reactant: MODEL1310110063#
is described by: ECO:0000000
kinetic law: MODEL1310110063#
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reversible: true
type: Reaction
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
fast: false
is: SBO:0000185
product: MODEL1310110063#
modifier: MODEL1310110063#

http://identifiers.org/biomodels.db/MODEL1310110063#_7e4932fe_fedb_4a12_9f29_240c4287be12
is: SBO:0000252
has only substance units: false
constant: false
is encoded by: hsa:171425
initial amount: NaN
initial concentration: NaN
name: CLYBL
boundary condition: true
type: Species

http://identifiers.org/biomodels.db/MODEL1310110063#_f31ba7c7_606e_42b0_ac84_7c927a999bdc
initial concentration: NaN
name: ACHE
is encoded by: hsa:43
is: SBO:0000252
constant: false
type: Species
has only substance units: false
initial amount: NaN
boundary condition: true

metaR FAOXC163C142x
kinetic law: MODEL1310110063#
product: MODEL1310110063#
reactant: MODEL1310110063#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C16:3-->C14:2)x
type: Reaction

metaM hs deg4 l
name: heparan sulfate, degradation product 4
boundary condition: false
initial amount: NaN
notes: FORMULA: C73H104N4O92S10 CHARGE: -12
initial concentration: 1.0
is: CHEBI:16126
is: SBO:0000247
constant: false
type: Species
has only substance units: false

metaM o2 c
name: O2
is: HMDB01377
initial concentration: 1.0
initial amount: NaN
is: C00007
has only substance units: false
constant: false
type: Species
is: SBO:0000247
notes: FORMULA: O2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00017 EHMN_ABBREVIATION: C00007
is: CHEBI:15379
boundary condition: false

metaM dctp c
boundary condition: false
initial concentration: 1.0
type: Species
name: dCTP
is: C00458
notes: FORMULA: C9H12N3O13P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00367 EHMN_ABBREVIATION: C00458
is: CHEBI:16311
has only substance units: false
constant: false
is: SBO:0000247
initial amount: NaN
is: HMDB00998

metaR G14T14g
is described by: ECO:0000000
reversible: false
is version of: http://identifiers.org/ec-code/2.4.1.22
is version of: http://identifiers.org/ec-code/2.4.1.90
product: MODEL1310110063#
fast: false
reactant: MODEL1310110063#
notes: GENE_ASSOCIATION: (8703.1) or (8704.2) or (8704.1) or (2683.1) or (9334.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.38 Confidence Level: 4 AUTHORS: PMID:12512857,PMID:1903938,PMID:3094506,PMID:3144273,PMID:9405390,PMID:9435216 NOTES:Keratan sulfate I biosynthesis NCD
is version of: http://identifiers.org/ec-code/2.4.1.38
name: beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase, Golgi
kinetic law: MODEL1310110063#
modifier: MODEL1310110063#
type: Reaction
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110063#_e601daa9_ed5d_45c0_b199_eabba1771b60
has only substance units: false
boundary condition: true
is: P17707
constant: false
initial amount: NaN
is: SBO:0000252
type: Species
name: AMD1
is encoded by: hsa:262
initial concentration: NaN

metaR HEX1
reversible: false
notes: GENE_ASSOCIATION: (3098.3) or (80201.1) or (2645.3) or (3098.4) or (3099.1) or (2645.2) or (3098.5) or (2645.1) or (3098.1) or (3101.1) or (3098.2) SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: Confidence Level: 2 AUTHORS: NOTES:
is: SBO:0000176
modifier: MODEL1310110063#
kinetic law: MODEL1310110063#
is version of: http://identifiers.org/ec-code/2.7.1.2
product: MODEL1310110063#
fast: false
type: Reaction
name: hexokinase (D-glucose:ATP)
is version of: http://identifiers.org/ec-code/2.7.1.1
reactant: MODEL1310110063#
is described by: ECO:0000134

metaR G6PDH1rer
is described by: ECO:0000269
reactant: MODEL1310110063#
fast: false
kinetic law: MODEL1310110063#
is: SBO:0000176
reversible: true
is version of: http://identifiers.org/ec-code/1.1.1.47
type: Reaction
product: MODEL1310110063#
modifier: MODEL1310110063#
notes: GENE_ASSOCIATION: (9563.1) SUBSYSTEM: Pentose phosphate pathway EC Number: 1.1.1.47 Confidence Level: 4 AUTHORS: PMID:10349511,PMID:12831846,PMID:2156506 NOTES:tv, jp NCD
name: glucose-6-phosphate dehydrogenase, endoplasmic reticulum

metaR DM taur LPAREN c RPAREN
kinetic law: MODEL1310110063#
reactant: MODEL1310110063#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: demand reaction for taurine
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110063#_53ff48de_3b29_468c_872e_63098b33f907
initial concentration: NaN
is: SBO:0000252
initial amount: NaN
is: B4DG68
type: Species
has only substance units: false
boundary condition: true
constant: false
is encoded by: hsa:4842
name: NOS1

http://identifiers.org/biomodels.db/MODEL1310110063#_99a20a97_294a_4dac_9c4d_59e4dfd3161f
type: Species
constant: false
has only substance units: false
is: O95168
is encoded by: hsa:4710
initial concentration: NaN
name: NDUFB4
is: SBO:0000252
boundary condition: true
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110063#_901519fa_bb56_4b75_ac1a_f4118316b024
name: NDUFB7
initial amount: NaN
has only substance units: false
is: SBO:0000252
initial concentration: NaN
is encoded by: hsa:4713
is: P17568
boundary condition: true
type: Species
constant: false

http://identifiers.org/biomodels.db/MODEL1310110063#_b55aade0_53e5_4054_bc69_cc423b138a61
initial concentration: NaN
is encoded by: hsa:5151
name: PDE8A
boundary condition: true
is: O60658
initial amount: NaN
type: Species
has only substance units: false
constant: false
is: SBO:0000252

metaM hexc e
boundary condition: false
has only substance units: false
type: Species
initial concentration: 1.0
is: HMDB02356
initial amount: NaN
is: CHEBI:31013
constant: false
is: SBO:0000247
notes: FORMULA: C26H51O2 CHARGE: -1 INCHI: InChI=1S/C26H52O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-24-25-26(27)28/h2-25H2,1H3,(H,27,28)/p-1
name: cerotate

metaM 3mox4hoxm m
constant: false
notes: FORMULA: C9H9O5 CHARGE: -1 INCHI: InChI=1S/C9H10O5/c1-14-7-4-5(2-3-6(7)10)8(11)9(12)13/h2-4,8,10-11H,1H3,(H,12,13)/p-1 HEPATONET_1.0_ABBREVIATION: HC01521 EHMN_ABBREVIATION: C05584
has only substance units: false
initial amount: NaN
type: Species
initial concentration: 1.0
is: CHEBI:27622
boundary condition: false
name: 3-Methoxy-4-hydroxymandelate
is: SBO:0000247
is: HMDB00291

metaR ASPGLUm
reversible: true
product: MODEL1310110063#
fast: false
reactant: MODEL1310110063#
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (8604.1) or (10165.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172 NOTES:TDV
name: aspartate-glutamate mitochondrial shuttle
modifier: MODEL1310110063#
is: SBO:0000185
kinetic law: MODEL1310110063#
type: Reaction

metaR r1634
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
product: MODEL1310110063#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
fast: false
type: Reaction
kinetic law: MODEL1310110063#
reversible: true
is: SBO:0000185
reactant: MODEL1310110063#

metaM nad r
has only substance units: false
is: CHEBI:57540
boundary condition: false
name: NAD(1-)
is: SBO:0000247
initial concentration: 1.0
is: HMDB00902
initial amount: NaN
constant: false
notes: FORMULA: C21H26N7O14P2 CHARGE: -1 INCHI: InChI=1S/C21H27N7O14P2/c22-17-12-19(25-7-24-17)28(8-26-12)21-16(32)14(30)11(41-21)6-39-44(36,37)42-43(34,35)38-5-10-13(29)15(31)20(40-10)27-3-1-2-9(4-27)18(23)33/h1-4,7-8,10-11,13-16,20-21,29-32H,5-6H2,(H5-,22,23,24,25,33,34,35,36,37)/p-1/t10-,11-,13-,14-,15-,16-,20-,21-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00013 EHMN_ABBREVIATION: C00003
type: Species

metaM creat e
type: Species
is: CHEBI:16919
boundary condition: false
initial amount: NaN
constant: false
initial concentration: 1.0
is: SBO:0000247
notes: FORMULA: C4H9N3O2 CHARGE: 0 INCHI: InChI=1S/C4H9N3O2/c1-7(4(5)6)2-3(8)9/h2H2,1H3,(H3,5,6)(H,8,9) HEPATONET_1.0_ABBREVIATION: HC00260 EHMN_ABBREVIATION: C00300
is: HMDB00064
name: creatine
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110063#_40121309_48a6_4bf9_ac8c_b464564009c2
initial concentration: NaN
name: PANK2
boundary condition: true
is: SBO:0000252
is: Q6P1K9
type: Species
initial amount: NaN
constant: false
has only substance units: false
is encoded by: hsa:80025

metaR RE3270C
product: MODEL1310110063#
name: RE3270
kinetic law: MODEL1310110063#
reactant: MODEL1310110063#
fast: false
type: Reaction
is: SBO:0000176
is described by: ECO:0000000
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Phosphatidylinositol phosphate metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:7556092 NOTES:IT - fixed proton

metaR 4NPHSULT
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.8.2.1
product: MODEL1310110063#
reversible: false
modifier: MODEL1310110063#
name: 4-Nitrophenol Sulfotransferase
fast: false
type: Reaction
kinetic law: MODEL1310110063#
is described by: ECO:0000269
reactant: MODEL1310110063#
notes: GENE_ASSOCIATION: (6799.1) or (6817.3) or (6799.2) or (6818.2) or (6817.2) or (6818.1) or (6817.1) or (6817.4) or (6818.3) or (6817.5) SUBSYSTEM: Cytochrome metabolism EC Number: 2.8.2.1 Confidence Level: 4 AUTHORS: PMID:11535246,PMID:15293241 NOTES:RS/TV (6/14/05)

http://identifiers.org/biomodels.db/MODEL1310110063#_28c512ef_0e15_408d_b45d_59148d094dde
name: HMGCS1
is: SBO:0000252
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:3157
has only substance units: false
constant: false
is: Q01581
boundary condition: true
type: Species

metaM 13 cis retn n
boundary condition: false
type: Species
is: D00348
initial amount: NaN
is: HMDB06219
is: SBO:0000247
has only substance units: false
initial concentration: 1.0
notes: FORMULA: C20H27O2 CHARGE: -1 INCHI: InChI=1/C20H28O2/c1-15(8-6-9-16(2)14-19(21)22)11-12-18-17(3)10-7-13-20(18,4)5/h6,8-9,11-12,14H,7,10,13H2,1-5H3,(H,21,22)/b9-6+,12-11+,15-8+,16-14- EHMN_ABBREVIATION: CE2952
constant: false
name: 13-cis-retinoate
is: http://identifiers.org/pubchem.compound/7847414

metaR LEUGLYHYc
product: MODEL1310110063#
fast: false
name: hydrolysis of leucylglycine
type: Reaction
is described by: ECO:0000134
reversible: true
reactant: MODEL1310110063#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 1 AUTHORS: most probable reaction. added during gap filling. NOTES:most probable reaction. added during gap filling.
is: SBO:0000176
kinetic law: MODEL1310110063#

http://identifiers.org/biomodels.db/MODEL1310110063#_9f6e1478_945c_4246_83df_20eef401e563
initial concentration: NaN
is encoded by: hsa:2645
is: SBO:0000252
name: GCK
has only substance units: false
initial amount: NaN
boundary condition: true
type: Species
constant: false

metaM c81crn c
is: HMDB13324
initial concentration: 1.0
boundary condition: false
notes: FORMULA: C15H27NO4 CHARGE: 0
initial amount: NaN
type: Species
has only substance units: false
name: octenoyl carnitine
constant: false
is: SBO:0000247

metaM m4mpdol U r
is: SBO:0000247
boundary condition: false
is: CHEBI:37633
constant: false
type: Species
name: (alpha-D-Mannosyl)4-beta-D-mannosyl-diacetylchitobiosyldiphosphodolichol, human uterine homolog
notes: FORMULA: C1485H2440N20O420P20 CHARGE: -20 INCHI: InChI=1S/C71H122N2O42P2/c1-30(2)13-9-14-31(3)15-10-16-32(4)17-11-18-33(5)19-12-20-34(6)21-22-101-116(96,97)115-117(98,99)114-66-45(73-36(8)81)52(88)60(42(28-79)107-66)109-65-44(72-35(7)80)51(87)61(41(27-78)106-65)110-69-59(95)62(50(86)43(108-69)29-100-67-57(93)53(89)46(82)37(23-74)102-67)111-70-64(56(92)49(85)39(25-76)104-70)113-71-63(55(91)48(84)40(26-77)105-71)112-68-58(94)54(90)47(83)38(24-75)103-68/h13,15,17,19,34,37-71,74-79,82-95H,9-12,14,16,18,20-29H2,1-8H3,(H,72,80)(H,73,81)(H,96,97)(H,98,99)/b31-15+,32-17+,33-19+/t34?,37-,38-,39-,40-,41-,42-,43-,44-,45-,46-,47-,48-,49-,50-,51-,52-,53+,54+,55+,56+,57+,58+,59+,60-,61-,62+,63+,64+,65+,66-,67+,68-,69+,70-,71-/m1/s1
initial concentration: 1.0
initial amount: NaN
has only substance units: false

metaR r0539
reversible: true
is described by: ECO:0000000
product: MODEL1310110063#
fast: false
kinetic law: MODEL1310110063#
reactant: MODEL1310110063#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.1.1.34
type: Reaction
notes: GENE_ASSOCIATION: (3156.1) SUBSYSTEM: Taurine and hypotaurine metabolism EC Number: 1.13.11.19 Confidence Level: 0 AUTHORS: PMID:17153586,PMID:17581819,PMID:3657558 NOTES:
modifier: MODEL1310110063#
name: Cysteamine:oxygen oxidoreductase Taurine and hypotaurine metabolism EC:1.13.11.19

metaR r1633
fast: false
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reactant: MODEL1310110063#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is described by: ECO:0000000
reversible: true
type: Reaction
product: MODEL1310110063#
kinetic law: MODEL1310110063#

metaM malttr e
is: HMDB01262
initial concentration: 1.0
constant: false
notes: FORMULA: C18H32O16 CHARGE: 0 INCHI: InChI=1S/C18H32O16/c19-1-4-7(22)8(23)12(27)17(31-4)34-15-6(3-21)32-18(13(28)10(15)25)33-14-5(2-20)30-16(29)11(26)9(14)24/h4-29H,1-3H2/t4-,5-,6-,7-,8+,9-,10-,11-,12-,13-,14-,15-,16+,17-,18-/m1/s1 EHMN_ABBREVIATION: C01835
boundary condition: false
is: SBO:0000247
is: CHEBI:27931
name: maltotriose
is: C01835
type: Species
has only substance units: false
initial amount: NaN

metaR GLYCt
product: MODEL1310110063#
fast: false
is described by: ECO:0000000
reactant: MODEL1310110063#
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:9405233 NOTES:NCD
is: SBO:0000185
kinetic law: MODEL1310110063#
name: glycerol transport via channel
type: Reaction

metaR EX arach LPAREN e RPAREN
kinetic law: MODEL1310110063#
reactant: MODEL1310110063#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for arachidate
type: Reaction

metaM 3hexdcoa m
type: Species
initial concentration: 1.0
initial amount: NaN
boundary condition: false
is: HMDB03932
constant: false
is: SBO:0000247
name: 3-hydroxyhexadecanoylcoa
is: C05258
notes: FORMULA: C37H62N7O18P3S CHARGE: -4
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110063#_c117d629_2810_449e_a866_7d7201d35cf0
initial amount: NaN
initial concentration: NaN
is: P57054
boundary condition: true
constant: false
is: SBO:0000252
has only substance units: false
name: PIGP
is encoded by: hsa:51227
type: Species

metaM 5tedtricoa x
name: 5,8,11-tetradecatrienoylcoa
initial concentration: 1.0
is: HMDB02288
initial amount: NaN
has only substance units: false
notes: FORMULA: C35H52N7O17P3S CHARGE: -4
is: SBO:0000247
type: Species
boundary condition: false
constant: false

metaM 5adtststerones c
is: HMDB06278
has only substance units: false
constant: false
name: 5alpha-Dihydrotestosterone sulfate
notes: FORMULA: C19H29O5S CHARGE: -1 INCHI: InChI=1/C19H30O5S/c1-18-9-7-13(20)11-12(18)3-4-14-15-5-6-17(24-25(21,22)23)19(15,2)10-8-16(14)18/h12,14-17H,3-11H2,1-2H3,(H,21,22,23)/t12-,14-,15-,16-,17-,18-,19-/m0/s1 EHMN_ABBREVIATION: CE6032
is: SBO:0000247
initial concentration: 1.0
boundary condition: false
initial amount: NaN
type: Species

metaR HEX7
is described by: ECO:0000304
notes: GENE_ASSOCIATION: (2645.2) or (2645.3) or (3098.3) or (3098.1) or (3101.1) or (3098.2) or (3099.1) or (2645.1) or (3098.4) or (80201.1) or (3098.5) SUBSYSTEM: Fructose and mannose metabolism EC Number: 2.7.1.1 Confidence Level: 2 AUTHORS: NOTES:D-Glucose, D-mannose, D-fructose, sorbitol and D-glucosamine can act as acceptors; ITP and dATP can act as donors. The liver isoenzyme has sometimes been called glucokinase. Same as 2.7.1.4
fast: false
is version of: http://identifiers.org/ec-code/2.7.1.1
name: hexokinase (D-fructose:ATP)
reversible: false
type: Reaction
kinetic law: MODEL1310110063#
modifier: MODEL1310110063#
reactant: MODEL1310110063#
product: MODEL1310110063#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.7.1.2

metaR r1636
product: MODEL1310110063#
fast: false
modifier: MODEL1310110063#
is described by: ECO:0000000
reversible: true
is: SBO:0000185
type: Reaction
reactant: MODEL1310110063#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
kinetic law: MODEL1310110063#
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:

metaM hexc c
has only substance units: false
boundary condition: false
initial concentration: 1.0
type: Species
is: HMDB02356
initial amount: NaN
is: CHEBI:31013
notes: FORMULA: C26H51O2 CHARGE: -1 INCHI: InChI=1S/C26H52O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-24-25-26(27)28/h2-25H2,1H3,(H,27,28)/p-1
name: cerotate
constant: false
is: SBO:0000247

metaR KSII CORE4t
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:
name: keratan sulfate II (core4) transport, golgi to extracellular
reactant: MODEL1310110063#
fast: false
kinetic law: MODEL1310110063#
reversible: false
product: MODEL1310110063#
is described by: ECO:0000000
type: Reaction
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110063#_8f2e29dc_5140_4b11_ae22_298affcc874c
boundary condition: true
is: Q9NY65
initial amount: NaN
is: SBO:0000252
is encoded by: hsa:1962
type: Species
constant: false
has only substance units: false
initial concentration: NaN
name: EHHADH

metaR FACOAL2042
is version of: http://identifiers.org/ec-code/6.2.1.3
is: SBO:0000176
notes: GENE_ASSOCIATION: (2180.1) SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 4 AUTHORS: PMID:15292367 NOTES:rev version so additional rxn doesn't need to be added to "unload" AA alternate to arachidonic acid (n-3 rather than n-6) NJ
is described by: ECO:0000000
fast: false
reversible: true
modifier: MODEL1310110063#
product: MODEL1310110063#
kinetic law: MODEL1310110063#
reactant: MODEL1310110063#
type: Reaction
name: fatty-acid--CoA ligase

metaM Ser Thr l
has only substance units: false
is: CHEBI:58190
notes: FORMULA: XH CHARGE: 0
initial amount: NaN
name: protein-linked serine or threonine residue (O-glycosylation site)
is: SBO:0000247
is: HMDB00224
initial concentration: 1.0
boundary condition: false
constant: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110063#_4f62ff1e_fbd8_4188_b256_d623a7958791
constant: false
is: Q13093
boundary condition: true
initial amount: NaN
type: Species
is: SBO:0000252
name: PLA2G7
initial concentration: NaN
is encoded by: hsa:7941
has only substance units: false

metaM 13dampp c
is: CHEBI:57484
is: SBO:0000247
initial concentration: 1.0
notes: FORMULA: C3H12N2 CHARGE: 2 INCHI: InChI=1S/C3H10N2/c4-2-1-3-5/h1-5H2/p+2 EHMN_ABBREVIATION: C00986
name: trimethylenediaminium
initial amount: NaN
has only substance units: false
boundary condition: false
constant: false
type: Species
is: HMDB00002

metaM core6 l
is: HMDB00143
has only substance units: false
boundary condition: false
initial concentration: 1.0
is: CHEBI:12936
initial amount: NaN
name: Core 6
notes: FORMULA: C16H27N2O10X CHARGE: 0
constant: false
is: SBO:0000247
type: Species

metaR HEX4
is described by: ECO:0000304
fast: false
reactant: MODEL1310110063#
product: MODEL1310110063#
type: Reaction
kinetic law: MODEL1310110063#
modifier: MODEL1310110063#
reversible: false
is version of: http://identifiers.org/ec-code/2.7.1.1
is version of: http://identifiers.org/ec-code/2.7.1.2
notes: GENE_ASSOCIATION: (3098.2) or (2645.2) or (3098.3) or (2645.3) or (3098.4) or (3099.1) or (3098.5) or (3098.1) or (3101.1) or (80201.1) or (2645.1) SUBSYSTEM: Fructose and mannose metabolism EC Number: 2.7.1.7 Confidence Level: 2 AUTHORS: NOTES:D-Glucose, D-mannose, D-fructose, sorbitol and D-glucosamine can act as acceptors; ITP and dATP can act as donors. The liver isoenzyme has sometimes been called glucokinase. also active in ecoli PMID: 4557975
is: SBO:0000176
name: hexokinase (D-mannose:ATP)

metaR r0311
is: SBO:0000176
type: Reaction
reversible: false
product: MODEL1310110063#
fast: false
notes: GENE_ASSOCIATION: (30.1) or (10449.1) or (38.1) or (39.1) or (3032.1) or (4645.1) SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 0 AUTHORS: PMID:8584017 NOTES:
is described by: ECO:0000000
modifier: MODEL1310110063#
reactant: MODEL1310110063#
kinetic law: MODEL1310110063#
name: Palmitate:CoA ligase (AMP-forming) Fatty acid metabolism EC:6.2.1.3
is version of: http://identifiers.org/ec-code/2.3.1.16
is version of: http://identifiers.org/ec-code/2.3.1.9

metaR EX sph1p LPAREN e RPAREN
kinetic law: MODEL1310110063#
reactant: MODEL1310110063#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Sphinganine 1-phosphate exchange
type: Reaction

metaM gln L m
is: CHEBI:18050
notes: FORMULA: C5H10N2O3 CHARGE: 0 INCHI: InChI=1S/C5H10N2O3/c6-3(5(9)10)1-2-4(7)8/h3H,1-2,6H2,(H2,7,8)(H,9,10)/t3-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00067
boundary condition: false
is: HMDB00641
constant: false
initial concentration: 1.0
has only substance units: false
type: Species
name: L-glutamine
initial amount: NaN
is: SBO:0000247

metaM nadp r
is: C00006
name: Nicotinamide adenine dinucleotide phosphate
boundary condition: false
notes: FORMULA: C21H25N7O17P3 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00016 EHMN_ABBREVIATION: C00006
is: CHEBI:58349
initial amount: NaN
type: Species
initial concentration: 1.0
has only substance units: false
is: HMDB00217
is: SBO:0000247
constant: false

metaM xylt c
notes: FORMULA: C5H12O5 CHARGE: 0 INCHI: InChI=1S/C5H12O5/c6-1-3(8)5(10)4(9)2-7/h3-10H,1-2H2/t3-,4+,5+ HEPATONET_1.0_ABBREVIATION: HC00317 EHMN_ABBREVIATION: C00379
name: xylitol
has only substance units: false
boundary condition: false
initial amount: NaN
initial concentration: 1.0
type: Species
constant: false
is: CHEBI:17151
is: SBO:0000247
is: HMDB02917

metaR H7 TAer
reactant: MODEL1310110063#
notes: GENE_ASSOCIATION: SUBSYSTEM: Phosphatidylinositol phosphate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:10727241,PMID:11483512,PMID:12802054,PMID:15632136,PMID:9356492,PMID:9468317 NOTES:EC 2.6.-.- NCD
is: SBO:0000176
name: H7' transamidase, endoplasmic reticulum
type: Reaction
product: MODEL1310110063#
reversible: false
is described by: ECO:0000000
kinetic law: MODEL1310110063#
fast: false

metaR r1635
is: SBO:0000185
kinetic law: MODEL1310110063#
reactant: MODEL1310110063#
is described by: ECO:0000000
modifier: MODEL1310110063#
type: Reaction
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reversible: true
product: MODEL1310110063#
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
fast: false

metaM c81crn e
initial concentration: 1.0
initial amount: NaN
boundary condition: false
notes: FORMULA: C15H27NO4 CHARGE: 0
type: Species
constant: false
name: octenoyl carnitine
is: SBO:0000247
has only substance units: false
is: HMDB13324

http://identifiers.org/biomodels.db/MODEL1310110063#_0ac2c920_28df_43d1_bb41_c89e7ac78727
boundary condition: true
initial concentration: NaN
type: Species
is encoded by: hsa:374907
constant: false
has only substance units: false
initial amount: NaN
name: B3GNT8
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110063#_418ce21f_ad0b_449a_8192_1ab99b6c85de
is encoded by: hsa:1807
type: Species
initial amount: NaN
name: DPYS
has only substance units: false
constant: false
is: SBO:0000252
initial concentration: NaN
boundary condition: true
is: Q14117

http://identifiers.org/biomodels.db/MODEL1310110063#_f1dc6f4c_085a_4c0b_ba67_426d08eadffd
name: AACS
has only substance units: false
is encoded by: hsa:65985
initial amount: NaN
boundary condition: true
initial concentration: NaN
type: Species
is: Q86V21
constant: false
is: SBO:0000252

metaM c226coa c
constant: false
boundary condition: false
notes: FORMULA: C43H62N7O17P3S CHARGE: -4 INCHI: InChI=1/C43H66N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-34(52)71-27-26-45-33(51)24-25-46-41(55)38(54)43(2,3)29-64-70(61,62)67-69(59,60)63-28-32-37(66-68(56,57)58)36(53)42(65-32)50-31-49-35-39(44)47-30-48-40(35)50/h5-6,8-9,11-12,14-15,17-18,20-21,30-32,36-38,42,53-54H,4,7,10,13,16,19,22-29H2,1-3H3,(H,45,51)(H,46,55)(H,59,60)(H,61,62)(H2,44,47,48)(H2,56,57,58)/b6-5-,9-8-,12-11-,15-14-,18-17-,21-20-/t32-,36-,37-,38?,42-/m1/s1
initial concentration: 1.0
type: Species
initial amount: NaN
is: SBO:0000247
name: cervonyl coenzyme A
is: http://identifiers.org/pubchem.compound/47205479
has only substance units: false
is: C16169

metaR KCC2t
fast: false
kinetic law: MODEL1310110063#
product: MODEL1310110063#
notes: GENE_ASSOCIATION: (6560.1) or (10723.1) or (9990.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10187864,PMID:10347194,PMID:10600773,PMID:121106695,PMID:12657561,PMID:8663127 NOTES:NCD
reactant: MODEL1310110063#
reversible: true
is described by: ECO:0000269
type: Reaction
is: SBO:0000185
modifier: MODEL1310110063#
name: K+-Cl- cotransporter (NH4+)

metaR FAOXC161C141x
kinetic law: MODEL1310110063#
product: MODEL1310110063#
reactant: MODEL1310110063#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta xoidation(C16:1-->C14:1)x
type: Reaction

metaR FAOXC241C221x
kinetic law: MODEL1310110063#
product: MODEL1310110063#
reactant: MODEL1310110063#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C24:1-->C22:1)x
type: Reaction

metaR r0494
reactant: MODEL1310110063#
type: Reaction
name: dTDP diphosphohydrolase Pyrimidine metabolism EC:3.6.1.5
is described by: ECO:0000000
product: MODEL1310110063#
fast: false
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Pyrimidine catabolism EC Number: 3.6.1.5 Confidence Level: 0 AUTHORS: PMID:15652174,PMID:16752921,PMID:17095758 NOTES:
reversible: true
kinetic law: MODEL1310110063#

metaR GLUtr
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: NOTES:unknown mechanism, needed to transport glu-L out of ER in conversion of leuktrC4-> leuktrD4 NJ
reactant: MODEL1310110063#
fast: false
is: SBO:0000185
type: Reaction
kinetic law: MODEL1310110063#
name: intracellular transport
product: MODEL1310110063#
reversible: true
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110063#_990795e3_c814_4fd2_9938_7fe28a115f66
constant: false
type: Species
boundary condition: true
is: SBO:0000252
name: _AA629629_1_m
is encoded by: hsa:AA629629
has only substance units: false
initial amount: NaN
initial concentration: NaN

metaR NTD3
name: 5'-nucleotidase (dCMP)
reversible: false
is version of: http://identifiers.org/ec-code/3.1.3.5
kinetic law: MODEL1310110063#
modifier: MODEL1310110063#
fast: false
type: Reaction
product: MODEL1310110063#
is: SBO:0000176
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (93034.1) or (30833.1) or (93034.2) SUBSYSTEM: Pyrimidine catabolism EC Number: 3.1.3.5 Confidence Level: 4 AUTHORS: PMID:11133996 NOTES:Wide specificity for 5'-nucleotides Also see EC 3.1.3.31
reactant: MODEL1310110063#

metaM c4dc e
initial amount: NaN
is: HMDB02013
type: Species
is: SBO:0000247
boundary condition: false
name: succinyl carnitine
is: C02862
notes: FORMULA: C11H18NO6 CHARGE: -1
has only substance units: false
constant: false
initial concentration: 1.0
is: http://identifiers.org/pubchem.compound/213144

http://identifiers.org/biomodels.db/MODEL1310110063#_176e4c67_0cf5_4687_9a52_a7514809136e
constant: false
boundary condition: true
has only substance units: false
is: SBO:0000252
is encoded by: hsa:5019
name: OXCT1
is: P55809
initial amount: NaN
type: Species
initial concentration: NaN

metaR r1700
type: Reaction
kinetic law: MODEL1310110063#
reversible: false
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
fast: false
reactant: MODEL1310110063#
is described by: ECO:0000000
name: Y+LAT2 Utilized transport
modifier: MODEL1310110063#
product: MODEL1310110063#
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110063#_61c19f19_632d_426b_868f_46459446503d
has only substance units: false
constant: false
type: Species
initial concentration: NaN
is encoded by: hsa:1632
is: SBO:0000252
name: ECI1
initial amount: NaN
is: P42126
boundary condition: true

metaM pheme c
initial concentration: 1.0
has only substance units: false
boundary condition: false
is: HMDB03178
is: CHEBI:17627
is: SBO:0000247
type: Species
notes: FORMULA: C34H30FeN4O4 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00041 EHMN_ABBREVIATION: C00032
is: C00032
constant: false
initial amount: NaN
name: Protoheme

http://identifiers.org/biomodels.db/MODEL1310110063#_4a385578_2e09_4669_9c4a_825064e88fe4
is: GO:0005634
is: SBO:0000290
constant: false
size: 1.0
spatial dimensions: 3.0
name: nucleus
type: Compartment

metaM thbpt4acam n
name: 4a-hydroxytetrahydrobiopterin
is: HMDB02281
is: SBO:0000247
is: CHEBI:15374
initial concentration: 1.0
type: Species
has only substance units: false
notes: FORMULA: C9H15N5O4 CHARGE: 0 INCHI: InChI=1S/C9H15N5O4/c1-3(15)5(16)4-2-11-6-9(18,14-4)7(17)13-8(10)12-6/h3-5,14-16,18H,2H2,1H3,(H3,10,11,12,13,17) EHMN_ABBREVIATION: CE1951
boundary condition: false
initial amount: NaN
constant: false

http://identifiers.org/biomodels.db/MODEL1310110063#_a6179462_60a6_47df_b30a_4a34ecfa641c
is: P28332
boundary condition: true
constant: false
is: SBO:0000252
is encoded by: hsa:130
initial concentration: NaN
name: ADH6
initial amount: NaN
has only substance units: false
type: Species

metaR FAOXC16OHC16r
kinetic law: MODEL1310110063#
product: MODEL1310110063#
reactant: MODEL1310110063#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid omega oxidation(C16-->w-OHC16)er
type: Reaction

metaR EX tyr L LPAREN e RPAREN
kinetic law: MODEL1310110063#
reactant: MODEL1310110063#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: L-Tyrosine exchange
type: Reaction

metaM 3htdcoa m
is: HMDB02288
is: SBO:0000247
type: Species
initial amount: NaN
notes: FORMULA: C35H58N7O18P3S CHARGE: -4
boundary condition: false
has only substance units: false
name: (S)-3-Hydroxytetradecanoyl-CoA
constant: false
initial concentration: 1.0

metaR r0642
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 1.2.1.3 Confidence Level: 0 AUTHORS: PMID:10947204,PMID:10989432,PMID:1527093,PMID:16683190,PMID:8120000,PMID:8155713,PMID:8634152,PMID:9787093 NOTES:
is described by: ECO:0000000
fast: false
reactant: MODEL1310110063#
reversible: true
type: Reaction
product: MODEL1310110063#
name: (S)-Methylmalonate semialdehyde:NAD+ oxidoreductase Valine, leucine and isoleucine degradation EC:1.2.1.3
kinetic law: MODEL1310110063#

http://identifiers.org/biomodels.db/MODEL1310110063#_0204b135_884f_47df_84d1_aa08442a7d85
initial amount: NaN
has only substance units: false
is encoded by: hsa:7498
type: Species
constant: false
name: XDH
is: P47989
is: SBO:0000252
initial concentration: NaN
boundary condition: true

metaM strdnccoa x
name: stearidonyl coenzyme A
notes: FORMULA: C39H58N7O17P3S CHARGE: -4 INCHI: InChI=1/C39H62N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-30(48)67-23-22-41-29(47)20-21-42-37(51)34(50)39(2,3)25-60-66(57,58)63-65(55,56)59-24-28-33(62-64(52,53)54)32(49)38(61-28)46-27-45-31-35(40)43-26-44-36(31)46/h5-6,8-9,11-12,14-15,26-28,32-34,38,49-50H,4,7,10,13,16-25H2,1-3H3,(H,41,47)(H,42,51)(H,55,56)(H,57,58)(H2,40,43,44)(H2,52,53,54)/b6-5-,9-8-,12-11-,15-14-/t28-,32-,33?,34+,38-/m1/s1
is: C16163
initial amount: NaN
is: http://identifiers.org/pubchem.compound/47205473
type: Species
is: SBO:0000247
boundary condition: false
initial concentration: 1.0
has only substance units: false
constant: false
is: HMDB06519

metaR ASNCYSNaEx
type: Reaction
is described by: ECO:0000269
fast: false
kinetic law: MODEL1310110063#
reactant: MODEL1310110063#
is: SBO:0000185
notes: GENE_ASSOCIATION: (6510.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14530974 NOTES:SAB see Kanai and Hediger 2004 (2003), PMID 14530974
modifier: MODEL1310110063#
product: MODEL1310110063#
reversible: false
name: L-cysteine/L-asparagine Na-dependent exchange (Asn-L in)

http://identifiers.org/biomodels.db/MODEL1310110063#_2ceda6be_ac45_4395_b907_b8fb1048b84a
initial concentration: NaN
is: SBO:0000252
initial amount: NaN
type: Species
is: O60909
name: B4GALT2
is encoded by: hsa:8704
boundary condition: true
has only substance units: false
constant: false

metaR RETt
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:1503811 NOTES:IT
name: Retinol transport via faciliated diffusion
reversible: false
reactant: MODEL1310110063#
fast: false
is described by: ECO:0000000
product: MODEL1310110063#
kinetic law: MODEL1310110063#
type: Reaction
is: SBO:0000185

metaR UMPK5n
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
is described by: ECO:0000269
kinetic law: MODEL1310110063#
product: MODEL1310110063#
name: UMP kinase (dATP),nuclear
type: Reaction
modifier: MODEL1310110063#
is: SBO:0000176
reversible: true
reactant: MODEL1310110063#
fast: false
is version of: http://identifiers.org/ec-code/2.7.4.14

metaR r0641
kinetic law: MODEL1310110063#
is: SBO:0000176
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/3.1.2.4
fast: false
product: MODEL1310110063#
notes: GENE_ASSOCIATION: (26275.1) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.2.2 Confidence Level: 0 AUTHORS: PMID:1968061 NOTES:
type: Reaction
modifier: MODEL1310110063#
reversible: true
reactant: MODEL1310110063#
name: (5-Glutamyl)-peptide:amino-acid 5-glutamyltransferase Arachidonic acid metabolism EC:2.3.2.2

metaM arachcrn m
has only substance units: false
type: Species
name: arachidyl carnitine
boundary condition: false
is: HMDB06460
notes: FORMULA: C27H53NO4 CHARGE: 0 INCHI: InChI=1/C27H53NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-27(31)32-25(23-26(29)30)24-28(2,3)4/h25H,5-24H2,1-4H3
constant: false
initial amount: NaN
initial concentration: 1.0
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110063#_dd631729_bd65_4ae4_9b7e_c05b4e9039bb
constant: false
initial concentration: NaN
is encoded by: hsa:586
initial amount: NaN
name: BCAT1
is: SBO:0000252
has only substance units: false
is: P54687
type: Species
boundary condition: true

metaM dec24dicoa x
notes: FORMULA: C31H46N7O17P3S CHARGE: -4
is: HMDB01168
constant: false
initial concentration: 1.0
is: SBO:0000247
boundary condition: false
has only substance units: false
type: Species
name: 2,4-decadienoylcoa
initial amount: NaN

metaR GLUDxm
fast: false
reactant: MODEL1310110063#
is described by: ECO:0000269
type: Reaction
modifier: MODEL1310110063#
kinetic law: MODEL1310110063#
is version of: http://identifiers.org/ec-code/1.4.1.3
reversible: true
name: glutamate dehydrogenase (NAD) (mitochondrial)
is: SBO:0000176
product: MODEL1310110063#
notes: GENE_ASSOCIATION: (2747.1) or (2746.1) SUBSYSTEM: Glutamate metabolism EC Number: 1.4.1.3 Confidence Level: 4 AUTHORS: PMID:12324473,PMID:3368458 NOTES:

metaR NTD1
product: MODEL1310110063#
fast: false
reactant: MODEL1310110063#
kinetic law: MODEL1310110063#
name: 5'-nucleotidase (dUMP)
reversible: false
is version of: http://identifiers.org/ec-code/3.1.3.5
is described by: ECO:0000269
modifier: MODEL1310110063#
type: Reaction
is: SBO:0000176
notes: GENE_ASSOCIATION: (30833.1) SUBSYSTEM: Pyrimidine catabolism EC Number: 3.1.3.5 Confidence Level: 4 AUTHORS: PMID:10899995 NOTES:Wide specificity for 5'-nucleotides Also see EC 3.1.3.31

http://identifiers.org/biomodels.db/MODEL1310110063#_3e58d1ab_a8a4_4200_9c7b_d95b1acfdc7f
is: SBO:0000252
boundary condition: true
initial amount: NaN
has only substance units: false
is: B4E3E9
type: Species
is encoded by: hsa:4967
constant: false
name: OGDH
initial concentration: NaN

metaR r1050
fast: false
product: MODEL1310110063#
name: Vesicular transport
is described by: ECO:0000000
kinetic law: MODEL1310110063#
reversible: true
type: Reaction
reactant: MODEL1310110063#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:10772724,PMID:12856181 NOTES:

metaM txa2 e
has only substance units: false
constant: false
is: CHEBI:57445
name: thromboxane A2(1-)
notes: FORMULA: C20H31O5 CHARGE: -1 INCHI: InChI=1S/C20H32O5/c1-2-3-6-9-15(21)12-13-17-16(18-14-20(24-17)25-18)10-7-4-5-8-11-19(22)23/h4,7,12-13,15-18,20-21H,2-3,5-6,8-11,14H2,1H3,(H,22,23)/p-1/b7-4-,13-12+/t15-,16+,17+,18-,20+/m0/s1 EHMN_ABBREVIATION: C02198
initial concentration: 1.0
type: Species
is: SBO:0000247
initial amount: NaN
boundary condition: false
is: HMDB01452

metaR GCC2cm
kinetic law: MODEL1310110063#
modifier: MODEL1310110063#
type: Reaction
product: MODEL1310110063#
fast: false
is version of: http://identifiers.org/ec-code/1.4.4.2
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.8.1.4
notes: GENE_ASSOCIATION: (275.1) and (1738.1) and (2731.1) and (2653.1) SUBSYSTEM: Glycine, serine, alanine and threonine metabolism EC Number: 2.1.2.10 Confidence Level: 4 AUTHORS: PMID:15355973 NOTES:NCD
is version of: http://identifiers.org/ec-code/2.1.2.10
reactant: MODEL1310110063#
is described by: ECO:0000269
name: glycine-cleavage complex (lipoamide), mitochondrial
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110063#_7143681b_3aa9_4a32_bee6_bacd4defb3a9
initial amount: NaN
is: SBO:0000252
is encoded by: hsa:5198
is: Q6P4B4
constant: false
boundary condition: true
has only substance units: false
type: Species
initial concentration: NaN
name: PFAS

metaM adrncoa x
is: C16170
notes: FORMULA: C43H66N7O17P3S CHARGE: -4 INCHI: InChI=1/C43H70N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-34(52)71-27-26-45-33(51)24-25-46-41(55)38(54)43(2,3)29-64-70(61,62)67-69(59,60)63-28-32-37(66-68(56,57)58)36(53)42(65-32)50-31-49-35-39(44)47-30-48-40(35)50/h8-9,11-12,14-15,17-18,30-32,36-38,42,53-54H,4-7,10,13,16,19-29H2,1-3H3,(H,45,51)(H,46,55)(H,59,60)(H,61,62)(H2,44,47,48)(H2,56,57,58)/b9-8-,12-11-,15-14-,18-17-/t32-,36-,37-,38?,42-/m1/s1
name: adrenyl coenzyme A
is: SBO:0000247
has only substance units: false
type: Species
is: http://identifiers.org/pubchem.compound/47205480
constant: false
initial concentration: 1.0
boundary condition: false
initial amount: NaN

metaM hs l
is: SBO:0000247
name: heparan sulfate, free chain
type: Species
constant: false
notes: FORMULA: C79H114N5O102S12 CHARGE: -13
boundary condition: false
initial concentration: 1.0
has only substance units: false
is: CHEBI:28815
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110063#_4df2dd73_40e6_4525_83c0_3d2abe4865d8
boundary condition: true
name: PDE9A
is encoded by: hsa:5152
constant: false
initial concentration: NaN
type: Species
is: SBO:0000252
has only substance units: false
initial amount: NaN

metaM phe L c
has only substance units: false
initial amount: NaN
constant: false
notes: FORMULA: C9H11NO2 CHARGE: 0 INCHI: InChI=1S/C9H11NO2/c10-8(9(11)12)6-7-4-2-1-3-5-7/h1-5,8H,6,10H2,(H,11,12)/t8-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00081 EHMN_ABBREVIATION: C00079
is: CHEBI:17295
is: SBO:0000247
name: L-phenylalanine
boundary condition: false
type: Species
is: HMDB00159
initial concentration: 1.0

metaR EX 4mop LPAREN e RPAREN
kinetic law: MODEL1310110063#
reactant: MODEL1310110063#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: Exchange of 4-methyl-2-oxopentanoate
type: Reaction

metaR EX q10 LPAREN e RPAREN
kinetic law: MODEL1310110063#
reactant: MODEL1310110063#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for ubiquinone
type: Reaction

metaR r1421
kinetic law: MODEL1310110063#
type: Reaction
reversible: true
is: SBO:0000185
fast: false
product: MODEL1310110063#
name: Free diffusion
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: 4.2.1.1 Confidence Level: 0 AUTHORS: PMID:10938543,PMID:11493685,PMID:12713833,PMID:12747791,PMID:14640555,PMID:17259996,PMID:17504134,PMID:17826101,PMID:7011879,PMID:7672338 NOTES:
reactant: MODEL1310110063#
is described by: ECO:0000000

metaM pheme e
initial concentration: 1.0
initial amount: NaN
is: HMDB03178
is: SBO:0000247
is: CHEBI:17627
notes: FORMULA: C34H30FeN4O4 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00041 EHMN_ABBREVIATION: C00032
type: Species
boundary condition: false
constant: false
name: Protoheme
has only substance units: false
is: C00032

metaM fe3 e
boundary condition: false
is: CHEBI:29034
type: Species
constant: false
is: SBO:0000247
has only substance units: false
initial concentration: 1.0
name: Fe3+
initial amount: NaN
notes: FORMULA: Fe CHARGE: 3 HEPATONET_1.0_ABBREVIATION: HC01847
is: HMDB12943

http://identifiers.org/biomodels.db/MODEL1310110063#_b695defe_4021_4da8_afe8_c97d2186a46f
is: P33908
is: SBO:0000252
is encoded by: hsa:4121
has only substance units: false
name: MAN1A1
constant: false
initial amount: NaN
initial concentration: NaN
type: Species
boundary condition: true

metaR PYAM5POr
reactant: MODEL1310110063#
is described by: ECO:0000269
kinetic law: MODEL1310110063#
type: Reaction
name: pyridoxamine 5'-phosphate oxidase
fast: false
product: MODEL1310110063#
notes: GENE_ASSOCIATION: (55163.1) SUBSYSTEM: Vitamin B6 metabolism EC Number: 1.4.3.5 Confidence Level: 4 AUTHORS: PMID:6380540 NOTES:NCD IT
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.4.3.5
modifier: MODEL1310110063#
reversible: true

metaM C05965 e
constant: false
notes: FORMULA: C20H31O4 CHARGE: -1 INCHI: InChI=1S/C20H32O4/c1-2-3-4-5-10-13-16-19(24-23)17-14-11-8-6-7-9-12-15-18-20(21)22/h7-11,13-14,17,19,23H,2-6,12,15-16,18H2,1H3,(H,21,22)/p-1/b9-7-,11-8-,13-10-,17-14+/t19-/m0/s1 EHMN_ABBREVIATION: C05965
type: Species
initial amount: NaN
initial concentration: 1.0
is: CHEBI:57444
boundary condition: false
name: 12(S)-HPETE(1-)
is: HMDB04243
is: SBO:0000247
has only substance units: false

metaR PSFLIPm
name: phosphatidylserine flippase
notes: GENE_ASSOCIATION: (10396.1) or (57194.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:10198212,PMID:10856717,PMID:11353404 NOTES:See PMID: 10856717 - flippase activity no detailed data on which compartment ATP hydrolysis occurs, so for the time being assumed to be cytosolic NJ
is: SBO:0000185
reversible: false
modifier: MODEL1310110063#
product: MODEL1310110063#
kinetic law: MODEL1310110063#
is described by: ECO:0000269
fast: false
reactant: MODEL1310110063#
type: Reaction
is version of: http://identifiers.org/ec-code/3.6.3.1

metaR PI45P4P
type: Reaction
fast: false
product: MODEL1310110063#
reactant: MODEL1310110063#
name: phosphatidylinositol-4,5-bisphosphate 4-phosphatase
kinetic law: MODEL1310110063#
is: SBO:0000176
reversible: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Inositol phosphate metabolism EC Number: Confidence Level: 1 AUTHORS: PMID:10358929 NOTES:NCD
is described by: ECO:0000000

metaR r0644
is: SBO:0000176
is described by: ECO:0000000
kinetic law: MODEL1310110063#
reactant: MODEL1310110063#
fast: false
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 1.2.3.1 Confidence Level: 0 AUTHORS: PMID:11569919,PMID:16143537 NOTES:
reversible: true
name: (S)-Methylmalonate semialdehyde:oxygen oxidoreductase Valine, leucine and isoleucine degradation EC:1.2.3.1
product: MODEL1310110063#

metaM 3dodtricoa m
initial concentration: 1.0
initial amount: NaN
constant: false
is: HMDB11123
has only substance units: false
boundary condition: false
name: 3,6,9-dodecatrienoylcoa
notes: FORMULA: C33H48N7O17P3S CHARGE: -4
type: Species
is: C05279
is: SBO:0000247

metaR FAOXC122m
kinetic law: MODEL1310110063#
product: MODEL1310110063#
reactant: MODEL1310110063#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: isomerization(C12:2)m
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110063#_a4d2f6ef_c081_4a06_9595_be77a166f38c
type: Species
initial concentration: NaN
has only substance units: false
constant: false
boundary condition: true
initial amount: NaN
is: SBO:0000252
is encoded by: hsa:221823
name: PRPS1L1

metaR RE2974C
reactant: MODEL1310110063#
modifier: MODEL1310110063#
kinetic law: MODEL1310110063#
notes: GENE_ASSOCIATION: (8395.1) or (23396.1) or (5305.1) or (8396.1) or (79837.1) or (8394.1) SUBSYSTEM: Phosphatidylinositol phosphate metabolism EC Number: 2.7.1.68 Confidence Level: 0 AUTHORS: PMID:10231032,PMID:10358929,PMID:11493657,PMID:9211928 NOTES:
fast: false
is: SBO:0000176
name: RE2974
is version of: http://identifiers.org/ec-code/2.7.1.68
type: Reaction
reversible: true
product: MODEL1310110063#
is version of: http://identifiers.org/ec-code/2.7.1.149
is described by: ECO:0000000

metaM btn e
initial amount: NaN
is: HMDB00030
is: C00120
type: Species
has only substance units: false
constant: false
notes: FORMULA: C10H15N2O3S CHARGE: -1
is: CHEBI:3420
name: Biotin
is: SBO:0000247
boundary condition: false
initial concentration: 1.0

metaR FAOXC121C10x
kinetic law: MODEL1310110063#
product: MODEL1310110063#
reactant: MODEL1310110063#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta xoidation(C12:1-->C10)x
type: Reaction

metaR HPACtr
name: hydroxyphenylacetate transport via diffusion
is described by: ECO:0000000
reactant: MODEL1310110063#
type: Reaction
product: MODEL1310110063#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:3753983 NOTES:SAB
fast: false
kinetic law: MODEL1310110063#
reversible: true
is: SBO:0000185

metaM frdp x
initial amount: NaN
is: CHEBI:175763
constant: false
has only substance units: false
name: farnesyl pyrophosphate(3-)
initial concentration: 1.0
boundary condition: false
is: HMDB00961
type: Species
notes: FORMULA: C15H25O7P2 CHARGE: -3 INCHI: InChI=1S/C15H28O7P2/c1-13(2)7-5-8-14(3)9-6-10-15(4)11-12-21-24(19,20)22-23(16,17)18/h7,9,11H,5-6,8,10,12H2,1-4H3,(H,19,20)(H2,16,17,18)/p-3/b14-9+,15-11+ HEPATONET_1.0_ABBREVIATION: HC00362 EHMN_ABBREVIATION: C00448
is: SBO:0000247

metaM nmn c
has only substance units: false
is: C00455
notes: FORMULA: C11H14N2O8P CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00366 EHMN_ABBREVIATION: C00455
type: Species
initial concentration: 1.0
name: NMN
is: CHEBI:14649
is: HMDB00229
constant: false
is: SBO:0000247
initial amount: NaN
boundary condition: false

metaM txa2 c
type: Species
is: CHEBI:57445
is: SBO:0000247
has only substance units: false
notes: FORMULA: C20H31O5 CHARGE: -1 INCHI: InChI=1S/C20H32O5/c1-2-3-6-9-15(21)12-13-17-16(18-14-20(24-17)25-18)10-7-4-5-8-11-19(22)23/h4,7,12-13,15-18,20-21H,2-3,5-6,8-11,14H2,1H3,(H,22,23)/p-1/b7-4-,13-12+/t15-,16+,17+,18-,20+/m0/s1 EHMN_ABBREVIATION: C02198
boundary condition: false
is: HMDB01452
constant: false
name: thromboxane A2(1-)
initial amount: NaN
initial concentration: 1.0

metaR TETDEC2CRNe
kinetic law: MODEL1310110063#
product: MODEL1310110063#
reactant: MODEL1310110063#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: trnasport of tetradecadienoyl carnitine into extra cellular space
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110063#_24cfd9e1_7e00_4af3_9780_538249d2855f
boundary condition: true
has only substance units: false
constant: false
is encoded by: hsa:4711
initial amount: NaN
is: SBO:0000252
name: NDUFB5
type: Species
is: O43674
initial concentration: NaN

metaR r0643
product: MODEL1310110063#
kinetic law: MODEL1310110063#
reversible: true
type: Reaction
reactant: MODEL1310110063#
name: (S)-Methylmalonate semialdehyde:NAD+ oxidoreductase Valine, leucine and isoleucine degradation EC:1.2.1.3
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 1.2.1.3 Confidence Level: 0 AUTHORS: PMID:10947204,PMID:10989432,PMID:1527093,PMID:16683190,PMID:8120000,PMID:8155713,PMID:8634152,PMID:9787093 NOTES:
is: SBO:0000176
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110063#_0c478ed9_d722_4ebc_aa26_d4222fe2ee7f
is: P23786
boundary condition: true
constant: false
initial amount: NaN
name: CPT2
type: Species
is encoded by: hsa:1376
has only substance units: false
is: SBO:0000252
initial concentration: NaN

metaM pail5p hs c
initial concentration: 1.0
initial amount: NaN
is: CHEBI:57795
name: 1-phosphatidyl-1D-myo-inositol 5-phosphate(3-)
notes: FORMULA: C9H15O12P2FULLRCO2FULLR2CO2 CHARGE: -3
has only substance units: false
boundary condition: false
is: SBO:0000247
type: Species
constant: false

metaM C02470 c
has only substance units: false
initial concentration: 1.0
boundary condition: false
is: http://identifiers.org/pubchem.compound/5485
is: C02470
is: HMDB00881
initial amount: NaN
constant: false
type: Species
is: SBO:0000247
notes: FORMULA: C10H6NO4 CHARGE: -1 INCHI: InChI=1/C10H7NO4/c12-7-3-1-2-5-8(13)4-6(10(14)15)11-9(5)7/h1-4,12H,(H,11,13)(H,14,15) HEPATONET_1.0_ABBREVIATION: HC00945 EHMN_ABBREVIATION: C02470
name: Xanthurenic acid

metaM 3hexdtetcoa x
type: Species
constant: false
is: SBO:0000247
notes: FORMULA: C37H54N7O17P3S CHARGE: -4
boundary condition: false
name: 3,7,10,13-hexadecatetraenoylcoa
initial concentration: 1.0
initial amount: NaN
is: HMDB02288
has only substance units: false

metaR GALASE17ly
type: Reaction
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) or (5476.1) and (2720.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.23 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD
reactant: MODEL1310110063#
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/3.2.1.23
is version of: http://identifiers.org/ec-code/3.2.1.18
kinetic law: MODEL1310110063#
is: SBO:0000176
product: MODEL1310110063#
reversible: false
modifier: MODEL1310110063#
is version of: http://identifiers.org/ec-code/3.1.6.4
is version of: http://identifiers.org/ec-code/3.4.16.5
name: beta-galactosidase, lysosomal
fast: false

metaR FAOXC102x
kinetic law: MODEL1310110063#
product: MODEL1310110063#
reactant: MODEL1310110063#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: isomerization(C10:2)x
type: Reaction

metaR M7MASNBterg
reactant: MODEL1310110063#
kinetic law: MODEL1310110063#
reversible: false
is described by: ECO:0000000
is: SBO:0000185
type: Reaction
product: MODEL1310110063#
notes: GENE_ASSOCIATION: SUBSYSTEM: N-glycan synthesis EC Number: Confidence Level: 0 AUTHORS: NOTES:NCD
name: m7masnB transport from endoplasmic reticulum to Golgi apparatus
fast: false

metaR FAOXC143C123x
kinetic law: MODEL1310110063#
product: MODEL1310110063#
reactant: MODEL1310110063#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C14:3-->C12:3)x
type: Reaction

metaR CYTK11n
reactant: MODEL1310110063#
is: SBO:0000176
fast: false
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
reversible: true
is version of: http://identifiers.org/ec-code/2.7.4.14
is described by: ECO:0000269
name: cytidylate kinase (dCMP,dGTP),nuclear
modifier: MODEL1310110063#
kinetic law: MODEL1310110063#
product: MODEL1310110063#
type: Reaction

metaM aps c
initial concentration: 1.0
is: HMDB01003
initial amount: NaN
boundary condition: false
notes: FORMULA: C10H12N5O10PS CHARGE: -2 INCHI: InChI=1S/C10H14N5O10PS/c11-8-5-9(13-2-12-8)15(3-14-5)10-7(17)6(16)4(24-10)1-23-26(18,19)25-27(20,21)22/h2-4,6-7,10,16-17H,1H2,(H,18,19)(H2,11,12,13)(H,20,21,22)/p-2/t4-,6-,7-,10-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00204 EHMN_ABBREVIATION: C00224
has only substance units: false
is: CHEBI:58243
name: 5'-adenylyl sulfate(2-)
constant: false
is: SBO:0000247
type: Species

metaM c4crn x
is: HMDB02013
initial concentration: 1.0
type: Species
has only substance units: false
is: C02862
is: SBO:0000247
name: butyryl carnitine
constant: false
notes: FORMULA: C11H21NO4 CHARGE: 0
boundary condition: false
is: http://identifiers.org/pubchem.compound/213144
initial amount: NaN

metaM kynate c
is: HMDB00715
constant: false
is: CHEBI:58454
is: SBO:0000247
notes: FORMULA: C10H6NO3 CHARGE: -1 INCHI: InChI=1S/C10H7NO3/c12-9-5-8(10(13)14)11-7-4-2-1-3-6(7)9/h1-5H,(H,11,12)(H,13,14)/p-1 EHMN_ABBREVIATION: C01717
name: kynurenate
type: Species
boundary condition: false
has only substance units: false
initial concentration: 1.0
initial amount: NaN

metaM phe L e
is: CHEBI:17295
is: SBO:0000247
initial concentration: 1.0
is: HMDB00159
boundary condition: false
constant: false
has only substance units: false
name: L-phenylalanine
notes: FORMULA: C9H11NO2 CHARGE: 0 INCHI: InChI=1S/C9H11NO2/c10-8(9(11)12)6-7-4-2-1-3-5-7/h1-5,8H,6,10H2,(H,11,12)/t8-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00081 EHMN_ABBREVIATION: C00079
initial amount: NaN
type: Species

metaR UAGALDP
type: Reaction
product: MODEL1310110063#
reversible: false
fast: false
name: UDP-N-acetylgalactosamine diphosphorylase
reactant: MODEL1310110063#
is: SBO:0000176
is described by: ECO:0000000
kinetic law: MODEL1310110063#
notes: GENE_ASSOCIATION: SUBSYSTEM: Aminosugar metabolism EC Number: Confidence Level: 2 AUTHORS: NOTES:NCD

metaR PMTCOAtx
reversible: true
reactant: MODEL1310110063#
name: fatty acid intracellular transport
product: MODEL1310110063#
kinetic law: MODEL1310110063#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: NOTES:interaction between peroxisomes and ER (some enzymes on the outer membrane) NJ
is: SBO:0000185
is described by: ECO:0000000
type: Reaction
fast: false

metaM fe3 c
initial concentration: 1.0
has only substance units: false
notes: FORMULA: Fe CHARGE: 3
is: SBO:0000247
constant: false
name: Fe3+
type: Species
boundary condition: false
initial amount: NaN
is: HMDB12943

metaR EX tcynt LPAREN e RPAREN
kinetic law: MODEL1310110063#
reactant: MODEL1310110063#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Thiocyanate exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110063#_dda4dab6_fd65_41b6_979d_3bd2547e6d79
boundary condition: true
name: NDUFAB1
constant: false
initial amount: NaN
initial concentration: NaN
type: Species
is encoded by: hsa:4706
has only substance units: false
is: O14561
is: SBO:0000252

metaR RE0827E
fast: false
reversible: false
type: Reaction
is: SBO:0000176
kinetic law: MODEL1310110063#
modifier: MODEL1310110063#
notes: GENE_ASSOCIATION: (26.1) SUBSYSTEM: Urea cycle EC Number: 1.4.3.6 Confidence Level: 0 AUTHORS: PMID:10047787,PMID:7040832 NOTES:
name: RE0827
is version of: http://identifiers.org/ec-code/1.4.3.22
is described by: ECO:0000000
product: MODEL1310110063#
reactant: MODEL1310110063#

http://identifiers.org/biomodels.db/MODEL1310110063#_6c1929bb_e9e2_4b88_89e4_19d99069017f
is encoded by: hsa:29929
initial concentration: NaN
boundary condition: true
constant: false
initial amount: NaN
is: Q9Y672
has only substance units: false
is: SBO:0000252
name: ALG6
type: Species

metaM dgdp n
is: CHEBI:58595
boundary condition: false
is: HMDB00960
notes: FORMULA: C10H12N5O10P2 CHARGE: -3 INCHI: InChI=1S/C10H15N5O10P2/c11-10-13-8-7(9(17)14-10)12-3-15(8)6-1-4(16)5(24-6)2-23-27(21,22)25-26(18,19)20/h3-6,16H,1-2H2,(H,21,22)(H2,18,19,20)(H3,11,13,14,17)/p-3/t4-,5+,6+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00305 EHMN_ABBREVIATION: C00361
is: SBO:0000247
name: dGDP(2-)
type: Species
initial concentration: 1.0
initial amount: NaN
constant: false
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110063#_5cd41d0b_dd80_45ed_9f70_2c73a6cfff56
initial concentration: NaN
boundary condition: true
type: Species
name: _HG2846_HT2983_1_m
is encoded by: hsa:HG2846-HT2983
is: SBO:0000252
initial amount: NaN
has only substance units: false
constant: false

metaR EX tethex3 LPAREN e RPAREN
kinetic law: MODEL1310110063#
reactant: MODEL1310110063#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: tetracosahexaenoic acid, n-3 exchange
type: Reaction

metaM 3dpdhb me m
constant: false
has only substance units: false
initial amount: NaN
name: 3-Decaprenyl-4-hydroxy-5-methoxybenzoate
type: Species
boundary condition: false
is: SBO:0000247
is: CHEBI:50776
notes: FORMULA: C58H87O4 CHARGE: -1 INCHI: InChI=1S/C58H88O4/c1-44(2)22-13-23-45(3)24-14-25-46(4)26-15-27-47(5)28-16-29-48(6)30-17-31-49(7)32-18-33-50(8)34-19-35-51(9)36-20-37-52(10)38-21-39-53(11)40-41-54-42-55(58(60)61)43-56(62-12)57(54)59/h22,24,26,28,30,32,34,36,38,40,42-43,59H,13-21,23,25,27,29,31,33,35,37,39,41H2,1-12H3,(H,60,61)/b45-24+,46-26+,47-28+,48-30+,49-32+,50-34+,51-36+,52-38+,53-40+
initial concentration: 1.0

metaM cytd m
is: SBO:0000247
constant: false
name: cytidine
boundary condition: false
type: Species
notes: FORMULA: C9H13N3O5 CHARGE: 0 INCHI: InChI=1S/C9H13N3O5/c10-5-1-2-12(9(16)11-5)8-7(15)6(14)4(3-13)17-8/h1-2,4,6-8,13-15H,3H2,(H2,10,11,16)/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00381 EHMN_ABBREVIATION: C00475
has only substance units: false
initial amount: NaN
is: CHEBI:17562
is: HMDB00089
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110063#_42fac160_ac2a_4303_8ae4_351ff756c845
has only substance units: false
name: HSD17B4
is encoded by: hsa:3295
initial amount: NaN
is: E9PB82
is: SBO:0000252
initial concentration: NaN
type: Species
constant: false
boundary condition: true

metaR M16NTg
name: alpha-1,6-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase
notes: GENE_ASSOCIATION: (4247.1) SUBSYSTEM: N-glycan synthesis EC Number: 2.4.1.143 Confidence Level: 0 AUTHORS: PMID:12621063 NOTES:NCD
fast: false
is described by: ECO:0000000
type: Reaction
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.4.1.143
modifier: MODEL1310110063#
kinetic law: MODEL1310110063#
reactant: MODEL1310110063#
product: MODEL1310110063#
reversible: false

metaM btn c
has only substance units: false
name: Biotin
is: C00120
initial amount: NaN
notes: FORMULA: C10H15N2O3S CHARGE: -1
is: HMDB00030
boundary condition: false
type: Species
constant: false
initial concentration: 1.0
is: SBO:0000247
is: CHEBI:3420

metaR ASPte
reversible: true
kinetic law: MODEL1310110063#
is described by: ECO:0000134
name: diffusion of aspartate into blood
reactant: MODEL1310110063#
product: MODEL1310110063#
is: SBO:0000185
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 1 AUTHORS: added during gap-filling. no such transporter could be found so diffusion reaction is assumed. NOTES:
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110063#_8d739b59_47f7_49b2_8767_97d158b65762
initial amount: NaN
boundary condition: true
is: Q86YI5
constant: false
name: DLAT
type: Species
is: SBO:0000252
initial concentration: NaN
has only substance units: false
is encoded by: hsa:1737

metaR EX 4abutn LPAREN e RPAREN
kinetic law: MODEL1310110063#
reactant: MODEL1310110063#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of 4-ammoniobutanal
type: Reaction

metaR RE2625M
is: SBO:0000176
type: Reaction
modifier: MODEL1310110063#
name: RE2625
is described by: ECO:0000000
kinetic law: MODEL1310110063#
reactant: MODEL1310110063#
is version of: http://identifiers.org/ec-code/1.14.13.15
fast: false
product: MODEL1310110063#
reversible: true
notes: GENE_ASSOCIATION: (1593.1) SUBSYSTEM: Bile acid synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:9660774 NOTES:

metaM ksi deg10 l
initial amount: NaN
has only substance units: false
is: CHEBI:57455
is: HMDB01354
is: SBO:0000247
constant: false
initial concentration: 1.0
notes: FORMULA: C188H302N13O163S9 CHARGE: -9
name: keratan sulfate I, degradation product 10
type: Species
boundary condition: false

metaR AG13T11g
is described by: ECO:0000000
fast: false
modifier: MODEL1310110063#
is version of: http://identifiers.org/ec-code/2.4.1.149
name: N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase, Golgi apparatus
notes: GENE_ASSOCIATION: (79369.1) or (374907.1) or (11041.1) or (146712.1) or (374907.2) or (93010.1) or (10331.1) or (10678.1) or (10678.2) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.149 Confidence Level: 4 AUTHORS: PMID:10747980,PMID:11042166,PMID:12061784,PMID:12512857,PMID:15560372,PMID:15620693,PMID:9405606 NOTES:NCD
reversible: false
is: SBO:0000176
kinetic law: MODEL1310110063#
product: MODEL1310110063#
type: Reaction
reactant: MODEL1310110063#

metaR EX xyl D LPAREN e RPAREN
kinetic law: MODEL1310110063#
reactant: MODEL1310110063#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: D-Xylose exchange
type: Reaction

metaR BILGLCURtr
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: NOTES:unknown mechanism, however glucuronidated metabolites need to get out of the cell NJ
name: glucuronidated compound transport
fast: false
is described by: ECO:0000000
product: MODEL1310110063#
reversible: true
kinetic law: MODEL1310110063#
is: SBO:0000185
reactant: MODEL1310110063#

http://identifiers.org/biomodels.db/MODEL1310110063#_2ead523e_c36f_472c_99ad_0c5d1b074470
type: Species
initial amount: NaN
constant: false
is: SBO:0000252
has only substance units: false
boundary condition: true
initial concentration: NaN
name: _H77542_1_r
is encoded by: hsa:H77542

http://identifiers.org/biomodels.db/MODEL1310110063#_df75fa13_8a22_4287_ae4f_744815702462
name: PANK2
initial amount: NaN
has only substance units: false
initial concentration: NaN
boundary condition: true
is encoded by: hsa:80025
constant: false
type: Species
is: SBO:0000252

metaR r0497
is version of: http://identifiers.org/ec-code/1.2.4.2
product: MODEL1310110063#
type: Reaction
reversible: true
name: dTTP nucleotidohydrolase Pyrimidine metabolism EC:3.6.1.39
is described by: ECO:0000000
reactant: MODEL1310110063#
modifier: MODEL1310110063#
fast: false
notes: GENE_ASSOCIATION: (4967.1) or (55753.1) SUBSYSTEM: Pyrimidine catabolism EC Number: 3.6.1.39 Confidence Level: 0 AUTHORS: PMID:1320895,PMID:6097526,PMID:6297538 NOTES:
is: SBO:0000176
kinetic law: MODEL1310110063#

metaR DRIBt
product: MODEL1310110063#
kinetic law: MODEL1310110063#
reversible: true
is: SBO:0000185
name: deoxyribose transport via diffusion
reactant: MODEL1310110063#
type: Reaction
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:9693094 NOTES:NCD
is described by: ECO:0000000

metaR 34DHOXPEGt
reactant: MODEL1310110063#
kinetic law: MODEL1310110063#
is: SBO:0000185
is described by: ECO:0000000
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:7473774 NOTES:SAB
product: MODEL1310110063#
fast: false
name: 3,4-Dihydroxyphenylethyleneglycol transport (diffusion)
reversible: true

metaM dgdp m
initial amount: NaN
constant: false
has only substance units: false
initial concentration: 1.0
is: SBO:0000247
name: dGDP(2-)
is: CHEBI:58595
boundary condition: false
is: HMDB00960
type: Species
notes: FORMULA: C10H12N5O10P2 CHARGE: -3 INCHI: InChI=1S/C10H15N5O10P2/c11-10-13-8-7(9(17)14-10)12-3-15(8)6-1-4(16)5(24-6)2-23-27(21,22)25-26(18,19)20/h3-6,16H,1-2H2,(H,21,22)(H2,18,19,20)(H3,11,13,14,17)/p-3/t4-,5+,6+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00305 EHMN_ABBREVIATION: C00361

metaM gpi sig r
has only substance units: false
name: glycophosphatidylinositol (GPI) signal sequence (C-terminal peptide)
initial amount: NaN
notes: FORMULA: Y CHARGE: 0
is: HMDB00224
type: Species
constant: false
is: CHEBI:58190
initial concentration: 1.0
is: SBO:0000247
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110063#_4f436e49_8067_4900_83f1_70b01fee848c
name: PDE9A
is encoded by: hsa:5152
type: Species
is: SBO:0000252
constant: false
initial amount: NaN
has only substance units: false
boundary condition: true
initial concentration: NaN

metaM glyclt c
is: SBO:0000247
initial concentration: 1.0
boundary condition: false
is: HMDB00115
type: Species
name: glycolate
is: CHEBI:29805
has only substance units: false
initial amount: NaN
constant: false
notes: FORMULA: C2H3O3 CHARGE: -1 INCHI: InChI=1S/C2H4O3/c3-1-2(4)5/h3H,1H2,(H,4,5)/p-1 EHMN_ABBREVIATION: C00160

metaR HSAT1ly
is: SBO:0000185
type: Reaction
product: MODEL1310110063#
reversible: false
reactant: MODEL1310110063#
is described by: ECO:0000000
kinetic law: MODEL1310110063#
name: heparan-glucosaminide N-acetyltransferase, lysosomal
notes: GENE_ASSOCIATION: SUBSYSTEM: Heparan sulfate degradation EC Number: 2.3.1.78 Confidence Level: 4 AUTHORS: PMID:15591281,PMID:8993162 NOTES:The proton is located in the lysosome since it comes from oxidation of the NH3+ group in glucosamine. This reaction assumes that the other proton liberated from glucosamine reduces coa in the cytosol. NCD
fast: false

http://identifiers.org/biomodels.db/MODEL1310110063#_2732e03d_6953_4d3e_9666_0fd0f4be8bf8
boundary condition: true
initial amount: NaN
has only substance units: false
constant: false
is: SBO:0000252
is encoded by: hsa:10723
initial concentration: NaN
is: Q9Y666
type: Species
name: SLC12A7

http://identifiers.org/biomodels.db/MODEL1310110063#_cba627f8_cae5_4dc6_b693_543caaf419b0
is encoded by: hsa:2194
type: Species
boundary condition: true
name: FASN
is: P49327
initial concentration: NaN
constant: false
initial amount: NaN
has only substance units: false
is: SBO:0000252

metaR NRPPHRSFt
is: SBO:0000185
reactant: MODEL1310110063#
kinetic law: MODEL1310110063#
product: MODEL1310110063#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 1 AUTHORS: NOTES:SAB
type: Reaction
name: norepinephrine sulfate transport (diffusion)
fast: false
is described by: ECO:0000000
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110063#_7b6caddc_62d3_424d_ae48_2ec24686e2f9
initial concentration: NaN
type: Species
constant: false
initial amount: NaN
has only substance units: false
is encoded by: hsa:204
boundary condition: true
is: SBO:0000252
is: P54819
name: AK2

http://identifiers.org/biomodels.db/MODEL1310110063#_5c24e5c3_dba9_4cbe_b8e9_d488dcc97b78
initial concentration: NaN
is: P32119
name: PRDX2
boundary condition: true
type: Species
has only substance units: false
is: SBO:0000252
is encoded by: hsa:7001
initial amount: NaN
constant: false

metaR TMDPK
type: Reaction
notes: GENE_ASSOCIATION: (27010.1) SUBSYSTEM: Thiamine metabolism EC Number: Confidence Level: 4 AUTHORS: NOTES:
name: Thiamin pyrophosphokinase (EC 2.7.6.2)
modifier: MODEL1310110063#
is: SBO:0000176
reactant: MODEL1310110063#
is described by: ECO:0000269
fast: false
kinetic law: MODEL1310110063#
reversible: false
product: MODEL1310110063#
is version of: http://identifiers.org/ec-code/2.7.6.2

metaR GHMT2r
type: Reaction
modifier: MODEL1310110063#
is described by: ECO:0000269
name: glycine hydroxymethyltransferase, reversible
is: SBO:0000176
fast: false
reactant: MODEL1310110063#
notes: GENE_ASSOCIATION: (6470.1) or (6470.2) SUBSYSTEM: Glycine, serine, alanine and threonine metabolism EC Number: 2.1.2.1 Confidence Level: 4 AUTHORS: PMID:8505317,PMID:8611185,PMID:9038835 NOTES:NCD
product: MODEL1310110063#
is version of: http://identifiers.org/ec-code/2.1.2.1
kinetic law: MODEL1310110063#
reversible: true

metaM c4dc c
constant: false
boundary condition: false
is: SBO:0000247
is: http://identifiers.org/pubchem.compound/213144
initial amount: NaN
is: HMDB02013
name: succinyl carnitine
type: Species
initial concentration: 1.0
has only substance units: false
notes: FORMULA: C11H18NO6 CHARGE: -1
is: C02862

metaM dca r
constant: false
initial concentration: 1.0
is: SBO:0000247
initial amount: NaN
notes: FORMULA: C10H19O2 CHARGE: -1
is: HMDB00791
boundary condition: false
has only substance units: false
type: Species
name: Decanoate (n-C10:0)
is: C02838

metaR EX HC01444 LPAREN e RPAREN
kinetic law: MODEL1310110063#
reactant: MODEL1310110063#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of Galactosylglycerol
type: Reaction

metaR S2TASE2ly
notes: GENE_ASSOCIATION: (3423.1) or (3423.2) SUBSYSTEM: Heparan sulfate degradation EC Number: 3.1.6.13 Confidence Level: 4 AUTHORS: PMID:2122463,PMID:8244397,PMID:8530090,PMID:8993162 NOTES:NCD
is: SBO:0000176
modifier: MODEL1310110063#
fast: false
is version of: http://identifiers.org/ec-code/3.1.6.13
product: MODEL1310110063#
kinetic law: MODEL1310110063#
reversible: false
type: Reaction
is described by: ECO:0000000
reactant: MODEL1310110063#
name: iduronate-2-sulfatase, lysosomal

metaR SRTNtu
modifier: MODEL1310110063#
reactant: MODEL1310110063#
product: MODEL1310110063#
reversible: true
is described by: ECO:0000269
kinetic law: MODEL1310110063#
fast: false
is: SBO:0000185
name: Serotonin uniport
type: Reaction
notes: GENE_ASSOCIATION: (6580.1) or (6582.2) or (6582.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12883891 NOTES:SAB electrogenic, Na indepdendent & rev NJ

http://identifiers.org/biomodels.db/MODEL1310110063#_f343723c_7010_4f7e_a388_520f2820b8ea
is: Q9H3S5
has only substance units: false
is: SBO:0000252
initial amount: NaN
type: Species
name: PIGM
is encoded by: hsa:93183
boundary condition: true
initial concentration: NaN
constant: false

metaM Sfglutth c
boundary condition: false
constant: false
notes: FORMULA: C11H16N3O7S CHARGE: -1 INCHI: InChI=1S/C11H17N3O7S/c12-6(11(20)21)1-2-8(16)14-7(4-22-5-15)10(19)13-3-9(17)18/h5-7H,1-4,12H2,(H,13,19)(H,14,16)(H,17,18)(H,20,21)/p-1/t6-,7-/m0/s1 EHMN_ABBREVIATION: C01031
has only substance units: false
name: S-formylglutathionate(1-)
is: HMDB01550
initial concentration: 1.0
initial amount: NaN
type: Species
is: SBO:0000247
is: CHEBI:57688

metaR CITtam
type: Reaction
is: SBO:0000185
name: citrate transport, mitochondrial
reactant: MODEL1310110063#
reversible: true
product: MODEL1310110063#
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (6576.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172 NOTES:antiport with malate IF
kinetic law: MODEL1310110063#
fast: false
modifier: MODEL1310110063#

metaR TCHOLAtx
type: Reaction
fast: false
reversible: true
name: bile acid intracellular transport
kinetic law: MODEL1310110063#
is: SBO:0000185
reactant: MODEL1310110063#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: NOTES:unknown mechanism, however bile acids need to be secreted out of the cell NJ
is described by: ECO:0000000
product: MODEL1310110063#

http://identifiers.org/biomodels.db/MODEL1310110063#_ca971cc4_6727_4eeb_9753_bd2486d9e6fc
is: Q9P019
initial concentration: NaN
is encoded by: hsa:29085
name: PHPT1
boundary condition: true
is: SBO:0000252
has only substance units: false
type: Species
initial amount: NaN
constant: false

metaM C05280 m
initial amount: NaN
boundary condition: false
is: HMDB03952
name: cis,cis-3,6-Dodecadienoyl-CoA
has only substance units: false
is: CHEBI:28002
is: SBO:0000247
initial concentration: 1.0
constant: false
notes: FORMULA: C33H50N7O17P3S CHARGE: -4 INCHI: InChI=1S/C33H54N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-24(42)61-17-16-35-23(41)14-15-36-31(45)28(44)33(2,3)19-54-60(51,52)57-59(49,50)53-18-22-27(56-58(46,47)48)26(43)32(55-22)40-21-39-25-29(34)37-20-38-30(25)40/h8-9,11-12,20-22,26-28,32,43-44H,4-7,10,13-19H2,1-3H3,(H,35,41)(H,36,45)(H,49,50)(H,51,52)(H2,34,37,38)(H2,46,47,48)/b9-8-,12-11-/t22-,26-,27-,28+,32-/m1/s1 EHMN_ABBREVIATION: C05280
type: Species

metaM hexdpencoa x
is: SBO:0000247
is: HMDB02288
initial concentration: 1.0
boundary condition: false
type: Species
initial amount: NaN
name: 2,4,7,10,13-hexadecapentaenoylcoa
has only substance units: false
notes: FORMULA: C37H52N7O17P3S CHARGE: -4
constant: false

http://identifiers.org/biomodels.db/MODEL1310110063#_8747f8ec_5d88_49bb_bfb8_97715727f6f5
initial amount: NaN
boundary condition: true
is: SBO:0000252
name: SULT1A1
initial concentration: NaN
type: Species
has only substance units: false
constant: false
is encoded by: hsa:6817

metaR LNLCt
kinetic law: MODEL1310110063#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11788354,PMID:12864740 NOTES:NJ
is: SBO:0000185
name: Linoleic acid (n-C18:2) transport in via diffusion
is described by: ECO:0000000
reactant: MODEL1310110063#
fast: false
type: Reaction
reversible: true
product: MODEL1310110063#

http://identifiers.org/biomodels.db/MODEL1310110063#_43fa8e1a_82c5_4390_9cdc_d58913713fa7
type: Species
is: SBO:0000252
is encoded by: hsa:5315
initial concentration: NaN
constant: false
boundary condition: true
name: PKM2
initial amount: NaN
has only substance units: false

metaR ARGLYSex
product: MODEL1310110063#
fast: false
reversible: false
notes: GENE_ASSOCIATION: (9057.1 and 6520.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14770310 NOTES:SAB see PMID 14770310
modifier: MODEL1310110063#
name: Arginine/Lysine exchanger (Arg in)
kinetic law: MODEL1310110063#
is: SBO:0000185
type: Reaction
reactant: MODEL1310110063#
is described by: ECO:0000269

metaR ARAB Lt
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:12359133,PMID:15234337,PMID:2167807 NOTES:
fast: false
is: SBO:0000185
reversible: true
reactant: MODEL1310110063#
is described by: ECO:0000000
name: L-arabinoase extracellular transport
type: Reaction
kinetic law: MODEL1310110063#
product: MODEL1310110063#

metaM pacald c
is: HMDB06236
name: phenylacetaldehyde
initial amount: NaN
constant: false
is: SBO:0000247
is: CHEBI:16424
boundary condition: false
has only substance units: false
initial concentration: 1.0
type: Species
notes: FORMULA: C8H8O CHARGE: 0 INCHI: InChI=1S/C8H8O/c9-7-6-8-4-2-1-3-5-8/h1-5,7H,6H2 HEPATONET_1.0_ABBREVIATION: HC00448 EHMN_ABBREVIATION: C00601

metaM mn l
initial amount: NaN
is: HMDB06535
constant: false
initial concentration: 1.0
name: beta-1,4-mannose-N-acetylglucosamine
is: SBO:0000247
boundary condition: false
type: Species
notes: FORMULA: C14H25NO11 CHARGE: 0 INCHI: InChI=1/C14H25NO11/c1-4(18)15-7-9(20)12(6(3-17)24-13(7)23)26-14-11(22)10(21)8(19)5(2-16)25-14/h5-14,16-17,19-23H,2-3H2,1H3,(H,15,18)/t5-,6-,7-,8-,9-,10+,11+,12-,13-,14-/m1/s1
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110063#_350942a7_734c_4503_b73e_065dfde33cf4
has only substance units: false
boundary condition: true
initial concentration: NaN
initial amount: NaN
name: TUSC3
is encoded by: hsa:7991
is: SBO:0000252
type: Species
is: Q13454
constant: false

metaR NDPK6m
reactant: MODEL1310110063#
is version of: http://identifiers.org/ec-code/2.7.4.6
notes: GENE_ASSOCIATION: (4833.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.6 Confidence Level: 2 AUTHORS: PMID:9099850 NOTES:Many nucleoside diphosphates (eight described) can act as acceptors. While many ribo- and deoxyribonucleoside triphosphates can act as donors, only ATP is chosen as a donor to minimize the number of total reactions.
name: nucleoside-diphosphate kinase (ATP:dUDP), mitochondrial
type: Reaction
kinetic law: MODEL1310110063#
reversible: true
modifier: MODEL1310110063#
fast: false
is: SBO:0000176
product: MODEL1310110063#
is described by: ECO:0000254

metaR r0647
notes: GENE_ASSOCIATION: SUBSYSTEM: Tryptophan metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:18124509,PMID:6027578 NOTES:
reversible: true
fast: false
name: Spontaneous reaction
kinetic law: MODEL1310110063#
type: Reaction
reactant: MODEL1310110063#
is: SBO:0000176
is described by: ECO:0000000
product: MODEL1310110063#

http://identifiers.org/biomodels.db/MODEL1310110063#_26b54ec8_888f_4935_bb39_0dbc0eec6203
type: Species
constant: false
is encoded by: hsa:4731
boundary condition: true
is: SBO:0000252
name: NDUFV3
has only substance units: false
initial concentration: NaN
initial amount: NaN

metaM glyc3p x
boundary condition: false
notes: FORMULA: C3H7O6P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00095 EHMN_ABBREVIATION: C00093
is: C00093
is: CHEBI:57597
initial amount: NaN
constant: false
is: SBO:0000247
initial concentration: 1.0
is: HMDB00126
type: Species
has only substance units: false
name: Glycerol 3-phosphate

metaR r1117
name: Facilitated diffusion
kinetic law: MODEL1310110063#
product: MODEL1310110063#
fast: false
reactant: MODEL1310110063#
is: SBO:0000185
type: Reaction
reversible: true
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:17124168 NOTES:

metaR CRNCARtp
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 0 AUTHORS: NOTES:NCD
reactant: MODEL1310110063#
type: Reaction
product: MODEL1310110063#
is: SBO:0000185
is described by: ECO:0000000
fast: false
reversible: false
kinetic law: MODEL1310110063#
name: carnitine-acetylcarnitine carrier, peroxisomal

metaM gua c
is: HMDB00132
has only substance units: false
is: SBO:0000247
notes: FORMULA: C5H5N5O CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00219 EHMN_ABBREVIATION: C00242
is: CHEBI:16235
boundary condition: false
name: Guanine
constant: false
type: Species
initial amount: NaN
initial concentration: 1.0
is: C00242

metaR r0389
fast: false
product: MODEL1310110063#
type: Reaction
kinetic law: MODEL1310110063#
notes: GENE_ASSOCIATION: SUBSYSTEM: Vitamin B6 metabolism EC Number: 1.1.3.12 Confidence Level: 0 AUTHORS: PMID:6088736,PMID:9601034 NOTES:
is described by: ECO:0000000
is: SBO:0000176
reversible: true
name: Pyridoxine:oxygen oxidoreductase (deaminating) Vitamin B6 metabolism EC:1.1.3.12
reactant: MODEL1310110063#

http://identifiers.org/biomodels.db/MODEL1310110063#_020ed6fa_b8cb_4553_a839_3a31bd319836
is encoded by: hsa:BE042354
initial amount: NaN
has only substance units: false
is: SBO:0000252
name: _BE042354_1_m
boundary condition: true
type: Species
initial concentration: NaN
constant: false

metaR EX c51crn
kinetic law: MODEL1310110063#
reactant: MODEL1310110063#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for tiglyl carnitine
type: Reaction

metaM ocdca e
boundary condition: false
is: C01530
is: CHEBI:25629
notes: FORMULA: C18H35O2 CHARGE: -1 EHMN_ABBREVIATION: C01530
is: HMDB00827
initial concentration: 1.0
name: octadecanoate (n-C18:0)
is: SBO:0000247
constant: false
type: Species
initial amount: NaN
has only substance units: false

metaR RE2974N
product: MODEL1310110063#
reversible: true
is described by: ECO:0000000
name: RE2974
kinetic law: MODEL1310110063#
reactant: MODEL1310110063#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Phosphatidylinositol phosphate metabolism EC Number: 2.7.1.68 Confidence Level: 0 AUTHORS: PMID:10231032,PMID:10358929,PMID:11493657,PMID:9211928 NOTES:
is: SBO:0000176
fast: false

metaR r0755
notes: GENE_ASSOCIATION: (27034.1) or (28976.1) or (37.1) SUBSYSTEM: Unassigned EC Number: 1.2.1.5 Confidence Level: 0 AUTHORS: PMID:1898068 NOTES:
modifier: MODEL1310110063#
type: Reaction
reactant: MODEL1310110063#
reversible: true
fast: false
is: SBO:0000176
is described by: ECO:0000000
kinetic law: MODEL1310110063#
name: 3-Methoxy-4-hydroxyphenylacetaldehyde:NADP+ oxidoreductase Tyrosine metabolism EC:1.2.1.5
product: MODEL1310110063#

metaM pail34p hs c
initial amount: NaN
initial concentration: 1.0
is: CHEBI:57658
type: Species
notes: FORMULA: C9H14O15P3FULLRCO2FULLR2CO2 CHARGE: -5
is: SBO:0000247
boundary condition: false
has only substance units: false
constant: false
name: 1-phosphatidyl-1D-myo-inositol 3,4-bisphosphate(5-)

metaR r2099
fast: false
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
is: SBO:0000185
modifier: MODEL1310110063#
product: MODEL1310110063#
is described by: ECO:0000000
reactant: MODEL1310110063#
kinetic law: MODEL1310110063#
type: Reaction
reversible: true

metaR RNDR1
product: MODEL1310110063#
is described by: ECO:0000254
type: Reaction
kinetic law: MODEL1310110063#
fast: false
modifier: MODEL1310110063#
reactant: MODEL1310110063#
is version of: http://identifiers.org/ec-code/1.17.4.1
is: SBO:0000176
reversible: false
name: ribonucleoside-diphosphate reductase (ADP)
notes: GENE_ASSOCIATION: (6240.1 and 6241.1) SUBSYSTEM: Nucleotide interconversion EC Number: 1.7.14.1 Confidence Level: 2 AUTHORS: PMID:14729598 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110063#_75eaa369_3f2e_4fbe_9f43_848318ae26d5
initial concentration: NaN
constant: false
initial amount: NaN
boundary condition: true
type: Species
is: Q5TDP6
is: SBO:0000252
is encoded by: hsa:51557
name: LGSN
has only substance units: false

metaM m2emgacpail hs r
is: CHEBI:24636
is: http://identifiers.org/pubchem.compound/3380
type: Species
name: (dimannosyl),(phosphoethanolaminyl)-mannosyl-glucosylaminyl-acylphosphatidylinositol (H6)
is: C00080
has only substance units: false
boundary condition: false
constant: false
is: SBO:0000247
initial concentration: 1.0
initial amount: NaN
notes: FORMULA: C51H94N2O32P2FULLRCO2FULLR2CO2 CHARGE: 0

http://identifiers.org/biomodels.db/MODEL1310110063#_d95244ea_5d5d_49df_9beb_cf95df7bbf03
constant: false
has only substance units: false
type: Species
initial amount: NaN
boundary condition: true
is encoded by: hsa:AA854479
name: _AA854479_1_m
initial concentration: NaN
is: SBO:0000252

metaM glyc S c
has only substance units: false
initial amount: NaN
notes: FORMULA: C3H5O4 CHARGE: 0
is: CHEBI:33871
type: Species
boundary condition: false
is: HMDB06372
constant: false
initial concentration: 1.0
is: SBO:0000247
name: (S)-Glycerate

metaR GALtly
reversible: false
type: Reaction
product: MODEL1310110063#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 2 AUTHORS: PMID:1751541,PMID:8993166 NOTES:NCD
reactant: MODEL1310110063#
is described by: ECO:0000000
is: SBO:0000185
kinetic law: MODEL1310110063#
name: galactose efflux from lysosome
fast: false

metaM dhap x
is: http://identifiers.org/pubchem.compound/3411
initial amount: NaN
is: HMDB01473
constant: false
has only substance units: false
initial concentration: 1.0
name: Dihydroxyacetone phosphate
is: CHEBI:57642
is: SBO:0000247
boundary condition: false
is: C00111
type: Species

metaM 6pgc r
is: HMDB01316
is: CHEBI:58759
constant: false
boundary condition: false
notes: FORMULA: C6H10O10P CHARGE: -3 INCHI: InChI=1S/C6H13O10P/c7-2(1-16-17(13,14)15)3(8)4(9)5(10)6(11)12/h2-5,7-10H,1H2,(H,11,12)(H2,13,14,15)/p-3/t2-,3-,4+,5-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00292 EHMN_ABBREVIATION: C00345
name: 6-phosphonatooxy-D-gluconate
initial amount: NaN
is: SBO:0000247
has only substance units: false
type: Species
initial concentration: 1.0

metaM frdp r
initial concentration: 1.0
initial amount: NaN
is: CHEBI:175763
has only substance units: false
is: HMDB00961
name: Farnesyl diphosphate
type: Species
is: C00448
constant: false
notes: FORMULA: C15H25O7P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00362 EHMN_ABBREVIATION: C00448
is: SBO:0000247
boundary condition: false

metaR PEt
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11591435,PMID:12814641,PMID:15599942,PMID:1679347,PMID:7487879,PMID:8188243 NOTES:
product: MODEL1310110063#
is: SBO:0000185
name: phosphatidylethanolamine transport
is described by: ECO:0000000
reactant: MODEL1310110063#
reversible: true
kinetic law: MODEL1310110063#
fast: false

metaR r1116
name: ATP Exporter (ATP-E) TCDB:9.A.6.1.1
reactant: MODEL1310110063#
is: SBO:0000185
kinetic law: MODEL1310110063#
product: MODEL1310110063#
reversible: true
type: Reaction
is described by: ECO:0000000
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:10913128,PMID:11147574,PMID:11557556,PMID:12269403,PMID:14613890,PMID:15210701,PMID:15958381,PMID:17124168,PMID:179827,PMID:18697206,PMID:3031070,PMID:3244197,PMID:9305892 NOTES:

metaR EX paf hs LPAREN e RPAREN
kinetic law: MODEL1310110063#
reactant: MODEL1310110063#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 1-alkyl 2-acteylglycerol 3-phosphocholine (homo sapiens) exchange
type: Reaction

metaM pmtcrn c
is: CHEBI:17490
has only substance units: false
is: HMDB00222
name: L-palmitoylcarnitine
initial concentration: 1.0
boundary condition: false
notes: FORMULA: C23H45NO4 CHARGE: 0 INCHI: InChI=1S/C23H45NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-23(27)28-21(19-22(25)26)20-24(2,3)4/h21H,5-20H2,1-4H3/t21-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01034 EHMN_ABBREVIATION: C02990
type: Species
initial amount: NaN
constant: false
is: SBO:0000247

metaR DHORD9
type: Reaction
is described by: ECO:0000269
is: SBO:0000185
product: MODEL1310110063#
is version of: http://identifiers.org/ec-code/1.3.5.2
kinetic law: MODEL1310110063#
reactant: MODEL1310110063#
notes: GENE_ASSOCIATION: (1723.1) SUBSYSTEM: Pyrimidine synthesis EC Number: 1.3.3.1 Confidence Level: 4 AUTHORS: PMID:10727948,PMID:9693067 NOTES:_06-15-05 - EC 1.3.3.1 IT based on Bader et al, 1998, Prot. Expr. Purif,., 13,414-422 (I guess it is ubiquinone but i am not sure ) (needs FMN as cofactor) v(enzyme is located in inner-membrane of mitochondria, reaction take place in cytosol (Fig. 8 Rawls et al PMID: 10727948 )
fast: false
reversible: false
name: dihydoorotic acid dehydrogenase (quinone10)
modifier: MODEL1310110063#

metaR r0754
is: SBO:0000176
is described by: ECO:0000000
reactant: MODEL1310110063#
is version of: http://identifiers.org/ec-code/2.3.1.85
name: 3-Methoxy-4-hydroxyphenylacetaldehyde:NAD+ oxidoreductase Tyrosine metabolism EC:1.2.1.5
notes: GENE_ASSOCIATION: (2194.1) SUBSYSTEM: Unassigned EC Number: 1.2.1.5 Confidence Level: 0 AUTHORS: PMID:17379813,PMID:18621017 NOTES:
fast: false
modifier: MODEL1310110063#
kinetic law: MODEL1310110063#
type: Reaction
product: MODEL1310110063#
reversible: true

metaR r0388
fast: false
reversible: true
type: Reaction
reactant: MODEL1310110063#
kinetic law: MODEL1310110063#
is described by: ECO:0000000
product: MODEL1310110063#
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Vitamin B6 metabolism EC Number: 1.4.3.5 Confidence Level: 0 AUTHORS: PMID:6088736,PMID:9601034 NOTES:
name: Pyridoxamine:oxygen oxidoreductase (deaminating) Vitamin B6 metabolism EC:1.4.3.5

metaM HC02204 c
constant: false
has only substance units: false
name: prostaglandin-b1
boundary condition: false
initial concentration: 1.0
notes: FORMULA: C20H31O4 CHARGE: -1 INCHI: InChI=1S/C20H32O4/c1-2-3-6-9-17(21)14-12-16-13-15-19(22)18(16)10-7-4-5-8-11-20(23)24/h12,14,17,21H,2-11,13,15H2,1H3,(H,23,24)/b14-12+/t17-/m0/s1 EHMN_ABBREVIATION: C00959
is: CHEBI:27624
type: Species
initial amount: NaN
is: SBO:0000247

metaR ACOAD1fm
modifier: MODEL1310110063#
type: Reaction
reversible: false
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/1.3.99.3
is: SBO:0000176
notes: GENE_ASSOCIATION: (80724.1) or (36.1) or (35.1) or (34.1) or (84129.1) or (27034.1) or (28976.1) SUBSYSTEM: Butanoate metabolism EC Number: 1.3.99.2 Confidence Level: 4 AUTHORS: PMID:2565344 NOTES:Assume NAD/NADH as acceptors Lumped long-chain acyl-CoA dehydrogenase (EC 1.3.99.13) This reaction is therefore equilivalent to trans-2-enoyl-CoA reductase (NAD) (EC 1.3.1.44)
kinetic law: MODEL1310110063#
reactant: MODEL1310110063#
fast: false
product: MODEL1310110063#
name: acyl-CoA dehydrogenase (butanoyl-CoA), mitochondrial
is version of: http://identifiers.org/ec-code/1.3.8.1

http://identifiers.org/biomodels.db/MODEL1310110063#_1a30394e_a1de_46ae_a5ff_fcb00e112153
is: SBO:0000252
name: AMPD3
is encoded by: hsa:272
is: B7Z763
boundary condition: true
has only substance units: false
initial amount: NaN
initial concentration: NaN
constant: false
type: Species

metaR FUMm
reversible: true
fast: false
notes: GENE_ASSOCIATION: (2271.1) SUBSYSTEM: Citric acid cycle EC Number: 4.2.1.2 Confidence Level: 0 AUTHORS: PMID:16774737,PMID:17111171,PMID:17111172 NOTES:IF. Biochemical
kinetic law: MODEL1310110063#
modifier: MODEL1310110063#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/4.2.1.2
is described by: ECO:0000134
reactant: MODEL1310110063#
product: MODEL1310110063#
name: fumarase, mitochondrial
type: Reaction

metaR KAS8
type: Reaction
name: b-ketoacyl synthetase (palmitate, n-C16:0)
fast: false
kinetic law: MODEL1310110063#
notes: GENE_ASSOCIATION: (2194.1) SUBSYSTEM: Fatty acid synthesis EC Number: 2.3.1.85 Confidence Level: 4 AUTHORS: PMID:11756679,PMID:15507492,PMID:2669958 NOTES:
modifier: MODEL1310110063#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.3.1.85
is described by: ECO:0000269
reactant: MODEL1310110063#
product: MODEL1310110063#
reversible: false

metaR r0757
type: Reaction
reversible: true
fast: false
reactant: MODEL1310110063#
notes: GENE_ASSOCIATION: (2643.1) SUBSYSTEM: Unassigned EC Number: 1.2.1.5 Confidence Level: 0 AUTHORS: PMID:17379813,PMID:18621017 NOTES:
is version of: http://identifiers.org/ec-code/3.5.4.16
is: SBO:0000176
product: MODEL1310110063#
is described by: ECO:0000000
name: 3-Methoxy-4-hydroxyphenylglycolaldehyde:NADP+ oxidoreductase Tyrosine metabolism EC:1.2.1.5
modifier: MODEL1310110063#
kinetic law: MODEL1310110063#

metaR FAOXC102m
kinetic law: MODEL1310110063#
product: MODEL1310110063#
reactant: MODEL1310110063#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: isomerization(C10:2)m
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110063#_6f8a182f_3b30_4d0b_99f4_37da386e0e23
type: Species
boundary condition: true
name: H6PD
is encoded by: hsa:9563
constant: false
initial amount: NaN
is: O95479
has only substance units: false
initial concentration: NaN
is: SBO:0000252

metaM gua e
notes: FORMULA: C5H5N5O CHARGE: 0 INCHI: InChI=1S/C5H5N5O/c6-5-9-3-2(4(11)10-5)7-1-8-3/h1H,(H4,6,7,8,9,10,11) HEPATONET_1.0_ABBREVIATION: HC00219 EHMN_ABBREVIATION: C00242
is: SBO:0000247
is: CHEBI:16235
has only substance units: false
boundary condition: false
constant: false
name: guanine
initial amount: NaN
type: Species
is: HMDB00132
initial concentration: 1.0

metaM thbpt4acam c
name: 4a-hydroxytetrahydrobiopterin
is: HMDB02281
initial concentration: 1.0
boundary condition: false
has only substance units: false
constant: false
is: CHEBI:15374
type: Species
initial amount: NaN
is: SBO:0000247
notes: FORMULA: C9H15N5O4 CHARGE: 0 INCHI: InChI=1S/C9H15N5O4/c1-3(15)5(16)4-2-11-6-9(18,14-4)7(17)13-8(10)12-6/h3-5,14-16,18H,2H2,1H3,(H3,10,11,12,13,17) EHMN_ABBREVIATION: CE1951

metaM 3thexddcoacrn c
name: 3-hydroxy trans7,10-hexadecadienoyl carnitine
initial amount: NaN
is: SBO:0000247
boundary condition: false
constant: false
is: HMDB02014
notes: FORMULA: C23H41NO5 CHARGE: 0
has only substance units: false
type: Species
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110063#_330e3931_b67c_4203_b985_ef01469653eb
is: B7Z3K8
has only substance units: false
is encoded by: hsa:51004
is: SBO:0000252
boundary condition: true
initial concentration: NaN
initial amount: NaN
type: Species
name: COQ6
constant: false

metaR FAOXC3DC
kinetic law: MODEL1310110063#
product: MODEL1310110063#
reactant: MODEL1310110063#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: malonylcoa-->malonylcarnitine
type: Reaction

metaR RNDR3
type: Reaction
product: MODEL1310110063#
is described by: ECO:0000269
reactant: MODEL1310110063#
fast: false
is: SBO:0000176
notes: GENE_ASSOCIATION: (6240.1 and 6241.1) SUBSYSTEM: Nucleotide interconversion EC Number: 1.7.14.1 Confidence Level: 4 AUTHORS: PMID:14729598 NOTES:
kinetic law: MODEL1310110063#
is version of: http://identifiers.org/ec-code/1.17.4.1
modifier: MODEL1310110063#
name: ribonucleoside-diphosphate reductase (CDP)
reversible: false

metaR EX o2s LPAREN e RPAREN
kinetic law: MODEL1310110063#
reactant: MODEL1310110063#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Superoxide anion exchange
type: Reaction

metaM strdnccoa m
boundary condition: false
notes: FORMULA: C39H58N7O17P3S CHARGE: -4 INCHI: InChI=1/C39H62N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-30(48)67-23-22-41-29(47)20-21-42-37(51)34(50)39(2,3)25-60-66(57,58)63-65(55,56)59-24-28-33(62-64(52,53)54)32(49)38(61-28)46-27-45-31-35(40)43-26-44-36(31)46/h5-6,8-9,11-12,14-15,26-28,32-34,38,49-50H,4,7,10,13,16-25H2,1-3H3,(H,41,47)(H,42,51)(H,55,56)(H,57,58)(H2,40,43,44)(H2,52,53,54)/b6-5-,9-8-,12-11-,15-14-/t28-,32-,33?,34+,38-/m1/s1
initial amount: NaN
type: Species
has only substance units: false
is: C16163
name: stearidonyl coenzyme A
constant: false
is: HMDB06519
is: http://identifiers.org/pubchem.compound/47205473
initial concentration: 1.0
is: SBO:0000247

metaR NACHEX9ly
is version of: http://identifiers.org/ec-code/3.2.1.52
is described by: ECO:0000000
reversible: false
is: SBO:0000176
type: Reaction
modifier: MODEL1310110063#
name: beta-N-acetylhexosaminidase, lysosomal
reactant: MODEL1310110063#
notes: GENE_ASSOCIATION: (3073.1 and 3074.1) or (3074.1) or (3073.1) SUBSYSTEM: Chondroitin sulfate degradation EC Number: 3.2.1.52 Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12706724,PMID:8993162 NOTES:NCD
product: MODEL1310110063#
kinetic law: MODEL1310110063#
fast: false

metaM glyc S e
name: (S)-Glycerate
initial amount: NaN
has only substance units: false
notes: FORMULA: C3H5O4 CHARGE: 0
is: CHEBI:33871
constant: false
is: SBO:0000247
type: Species
is: HMDB06372
boundary condition: false
initial concentration: 1.0

metaR r0756
modifier: MODEL1310110063#
product: MODEL1310110063#
type: Reaction
reversible: true
is version of: http://identifiers.org/ec-code/3.1.3.1
kinetic law: MODEL1310110063#
notes: GENE_ASSOCIATION: (248.1) or (249.1) or (250.1) or (251.1) SUBSYSTEM: Unassigned EC Number: 1.2.1.5 Confidence Level: 0 AUTHORS: PMID:17379813,PMID:18621017 NOTES:
name: 3-Methoxy-4-hydroxyphenylglycolaldehyde:NAD+ oxidoreductase Tyrosine metabolism EC:1.2.1.5
is: SBO:0000176
fast: false
is described by: ECO:0000000
reactant: MODEL1310110063#

http://identifiers.org/biomodels.db/MODEL1310110063#_d65633f4_7a92_4835_a77a_04097bd39799
is: O00154
boundary condition: true
name: ACOT7
has only substance units: false
initial concentration: NaN
constant: false
is encoded by: hsa:11332
is: SBO:0000252
type: Species
initial amount: NaN

metaM cgly e
initial concentration: 1.0
has only substance units: false
constant: false
is: SBO:0000247
name: L-cysteinylglycine
is: HMDB00078
notes: FORMULA: C5H10N2O3S CHARGE: 0 INCHI: InChI=1S/C5H10N2O3S/c6-3(2-11)5(10)7-1-4(8)9/h3,11H,1-2,6H2,(H,7,10)(H,8,9)/t3-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00784 EHMN_ABBREVIATION: C01419
type: Species
is: CHEBI:4047
boundary condition: false
initial amount: NaN

metaM btn n
is: HMDB00030
is: SBO:0000247
constant: false
type: Species
initial concentration: 1.0
initial amount: NaN
boundary condition: false
notes: FORMULA: C10H15N2O3S CHARGE: -1 INCHI: InChI=1S/C10H16N2O3S/c13-8(14)4-2-1-3-7-9-6(5-16-7)11-10(15)12-9/h6-7,9H,1-5H2,(H,13,14)(H2,11,12,15)/p-1/t6-,7-,9-/m0/s1 EHMN_ABBREVIATION: C00120
is: CHEBI:57586
name: biotinate
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110063#_5febcd17_17b4_4017_bf7d_402ed792a872
type: Species
initial concentration: NaN
constant: false
initial amount: NaN
is encoded by: hsa:771
boundary condition: true
has only substance units: false
name: CA12
is: SBO:0000252
is: O43570

metaR TRPt
reversible: true
is described by: ECO:0000269
fast: false
product: MODEL1310110063#
notes: GENE_ASSOCIATION: (117247.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:11827462 NOTES:
type: Reaction
modifier: MODEL1310110063#
is: SBO:0000185
name: L-tryptophan transport
kinetic law: MODEL1310110063#
reactant: MODEL1310110063#

http://identifiers.org/biomodels.db/MODEL1310110063#_84311d07_6f3e_4076_ab7e_a8b20c92ae48
is: SBO:0000252
constant: false
boundary condition: true
has only substance units: false
name: TREH
type: Species
initial amount: NaN
is: O43280
initial concentration: NaN
is encoded by: hsa:11181

http://identifiers.org/biomodels.db/MODEL1310110063#_98269b81_56a4_420d_bef1_b882df41cc25
constant: false
initial concentration: NaN
is encoded by: hsa:7371
has only substance units: false
is: Q9BZX2
is: SBO:0000252
initial amount: NaN
boundary condition: true
type: Species
name: UCK2

metaR RNDR4
is described by: ECO:0000254
type: Reaction
reversible: false
kinetic law: MODEL1310110063#
is version of: http://identifiers.org/ec-code/1.17.4.1
name: ribonucleoside-diphosphate reductase (UDP)
notes: GENE_ASSOCIATION: (6240.1 and 6241.1) SUBSYSTEM: Nucleotide interconversion EC Number: 1.7.14.1 Confidence Level: 2 AUTHORS: PMID:14729598 NOTES:
modifier: MODEL1310110063#
is: SBO:0000176
product: MODEL1310110063#
fast: false
reactant: MODEL1310110063#

metaM HC02204 e
is: SBO:0000247
type: Species
initial concentration: 1.0
notes: FORMULA: C20H31O4 CHARGE: -1 INCHI: InChI=1S/C20H32O4/c1-2-3-6-9-17(21)14-12-16-13-15-19(22)18(16)10-7-4-5-8-11-20(23)24/h12,14,17,21H,2-11,13,15H2,1H3,(H,23,24)/b14-12+/t17-/m0/s1 EHMN_ABBREVIATION: C00959
constant: false
initial amount: NaN
name: prostaglandin-b1
has only substance units: false
is: CHEBI:27624
boundary condition: false

metaM dec24dicoa m
type: Species
initial amount: NaN
is: SBO:0000247
has only substance units: false
is: HMDB01168
constant: false
name: 2,4-decadienoylcoa
boundary condition: false
notes: FORMULA: C31H46N7O17P3S CHARGE: -4
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110063#_59a08b06_fe12_4110_839e_ed9054507271
constant: false
type: Species
is: SBO:0000252
boundary condition: true
is: P42765
has only substance units: false
name: ACAA2
initial concentration: NaN
is encoded by: hsa:10449
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110063#_4b13f07f_7bf4_4666_9d3c_cb3bb5ecafeb
is: SBO:0000252
is: Q9UG56
has only substance units: false
boundary condition: true
initial concentration: NaN
initial amount: NaN
type: Species
constant: false
name: PISD
is encoded by: hsa:23761

metaM btn m
name: biotinate
initial concentration: 1.0
initial amount: NaN
is: SBO:0000247
has only substance units: false
constant: false
is: CHEBI:57586
is: HMDB00030
type: Species
boundary condition: false
notes: FORMULA: C10H15N2O3S CHARGE: -1 INCHI: InChI=1S/C10H16N2O3S/c13-8(14)4-2-1-3-7-9-6(5-16-7)11-10(15)12-9/h6-7,9H,1-5H2,(H,13,14)(H2,11,12,15)/p-1/t6-,7-,9-/m0/s1 EHMN_ABBREVIATION: C00120

http://identifiers.org/biomodels.db/MODEL1310110063#_a48376e6_8bb1_44e3_9fdd_ad18f7349a24
is encoded by: hsa:4710
name: NDUFB4
has only substance units: false
initial concentration: NaN
is: O95168
constant: false
initial amount: NaN
boundary condition: true
type: Species
is: SBO:0000252

metaR S6TASE11ly
type: Reaction
name: N-acetylglucosamine-6-sulfatase, lysosomal
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (2799.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.1.6.14 Confidence Level: 4 AUTHORS: PMID:3196333,PMID:3689314,PMID:3689315 NOTES:NCD
kinetic law: MODEL1310110063#
is: SBO:0000176
product: MODEL1310110063#
modifier: MODEL1310110063#
reversible: true
reactant: MODEL1310110063#
is version of: http://identifiers.org/ec-code/3.1.6.14
fast: false

metaM ksi pre21 g
is: CHEBI:58053
type: Species
initial concentration: 1.0
initial amount: NaN
boundary condition: false
is: SBO:0000247
name: keratan sulfate I biosynthesis, precursor 21
is: HMDB00175
has only substance units: false
notes: FORMULA: C177H284N12O145S6X CHARGE: -7
is: C00130
constant: false

metaR r0385
reversible: false
reactant: MODEL1310110063#
name: 3-methyl-2-oxobutanoate:[dihydrolipoyllysine-residue (2-methylpropanoyl)transferase] lipoyllysine 2-oxidoreductase (decarboxylating, acceptor-2-methylpropanoylating) EC:1.2.4.4
product: MODEL1310110063#
kinetic law: MODEL1310110063#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 1.2.4.4 Confidence Level: 0 AUTHORS: PMID:11839747,PMID:12387880,PMID:15576032 NOTES:
fast: false
is described by: ECO:0000000
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110063#_3f62de35_ea0f_4c38_8e68_e9c494416412
constant: false
name: PKLR
type: Species
initial concentration: NaN
initial amount: NaN
is: SBO:0000252
has only substance units: false
is encoded by: hsa:5313
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110063#_f1213390_a439_4417_b722_87025987c25b
is: SBO:0000252
name: BDH1
initial concentration: NaN
type: Species
is encoded by: hsa:622
constant: false
has only substance units: false
is: Q02338
boundary condition: true
initial amount: NaN

metaR r1879
type: Reaction
kinetic law: MODEL1310110063#
fast: false
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reactant: MODEL1310110063#
name: Y+LAT2 Utilized transport
is: SBO:0000185
modifier: MODEL1310110063#
product: MODEL1310110063#
is described by: ECO:0000000
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110063#_8ce1a757_23ed_43ce_b221_e3db26c99af4
initial amount: NaN
is: SBO:0000252
has only substance units: false
initial concentration: NaN
is: O75715
type: Species
constant: false
name: GPX5
is encoded by: hsa:2880
boundary condition: true

metaR UGLCNACtg
product: MODEL1310110063#
reactant: MODEL1310110063#
name: UDP-GlcNAc Golgi transport via CMP antiport
type: Reaction
fast: false
notes: GENE_ASSOCIATION: (11046.1) SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 4 AUTHORS: PMID:15082721,PMID:15607426 NOTES:NCD
is: SBO:0000185
reversible: true
modifier: MODEL1310110063#
is described by: ECO:0000269
kinetic law: MODEL1310110063#

metaR ALATHRNaEx
reactant: MODEL1310110063#
fast: false
modifier: MODEL1310110063#
notes: GENE_ASSOCIATION: (6509.1) or (6510.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14530974 NOTES:SAB see Kanai and Hediger 2004 (2003), PMID 14530974
reversible: false
kinetic law: MODEL1310110063#
product: MODEL1310110063#
type: Reaction
name: L-alanine/L-threonine Na-dependent exchange (Ala-L in)
is described by: ECO:0000269
is: SBO:0000185

metaR r2095
type: Reaction
reversible: true
product: MODEL1310110063#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
is: SBO:0000185
kinetic law: MODEL1310110063#
modifier: MODEL1310110063#
fast: false
reactant: MODEL1310110063#

metaM prist c
is: HMDB00795
is: CHEBI:51340
initial amount: NaN
type: Species
initial concentration: 1.0
constant: false
is: SBO:0000247
name: pristanic acid
notes: FORMULA: C19H37O2 CHARGE: -1 INCHI: InChI=1S/C19H38O2/c1-15(2)9-6-10-16(3)11-7-12-17(4)13-8-14-18(5)19(20)21/h15-18H,6-14H2,1-5H3,(H,20,21)
boundary condition: false
has only substance units: false

metaM 3thexddcoacrn e
initial amount: NaN
notes: FORMULA: C23H41NO5 CHARGE: 0
constant: false
name: 3-hydroxy trans7,10-hexadecadienoyl carnitine
initial concentration: 1.0
is: SBO:0000247
boundary condition: false
is: HMDB02014
type: Species
has only substance units: false

metaM tetpent3 c
boundary condition: false
type: Species
constant: false
initial concentration: 1.0
is: HMDB06323
initial amount: NaN
is: SBO:0000247
has only substance units: false
name: tetracosapentaenoic acid, n-3
notes: FORMULA: C24H37O2 CHARGE: -1 INCHI: InChI=1/C24H38O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-24(25)26/h3-4,6-7,9-10,12-13,15-16H,2,5,8,11,14,17-23H2,1H3,(H,25,26)/b4-3-,7-6-,10-9-,13-12-,16-15-

metaM cgly c
initial amount: NaN
is: CHEBI:4047
notes: FORMULA: C5H10N2O3S CHARGE: 0 INCHI: InChI=1S/C5H10N2O3S/c6-3(2-11)5(10)7-1-4(8)9/h3,11H,1-2,6H2,(H,7,10)(H,8,9)/t3-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00784 EHMN_ABBREVIATION: C01419
type: Species
has only substance units: false
name: L-cysteinylglycine
is: SBO:0000247
initial concentration: 1.0
is: HMDB00078
boundary condition: false
constant: false

metaR r0750
notes: GENE_ASSOCIATION: (2194.1) SUBSYSTEM: Bile acid synthesis EC Number: 1.1.1.50 Confidence Level: 0 AUTHORS: PMID:1591235,PMID:3459552 NOTES:
fast: false
is: SBO:0000176
reversible: true
is described by: ECO:0000000
reactant: MODEL1310110063#
name: 3alpha,7alpha,12alpha-Trihydroxy-5beta-cholestane:NADP+ oxidoreductase (B-specific); 3alpha,7alpha,12alpha-Trihydroxy-5beta-cholestane:NADP+ oxidoreductase Bile acid biosynthesis EC:1.1.1.50
kinetic law: MODEL1310110063#
type: Reaction
product: MODEL1310110063#
modifier: MODEL1310110063#
is version of: http://identifiers.org/ec-code/2.3.1.85

http://identifiers.org/biomodels.db/MODEL1310110063#_05315705_e0c7_4f87_a6b4_386abc4277c9
is: SBO:0000252
is: Q9UNU6
is encoded by: hsa:1582
initial concentration: NaN
initial amount: NaN
name: CYP8B1
has only substance units: false
boundary condition: true
type: Species
constant: false

http://identifiers.org/biomodels.db/MODEL1310110063#_993fd249_7664_4973_bed3_8ab3083af2b3
name: GALNT11
is: SBO:0000252
boundary condition: true
is: B3KWF4
initial concentration: NaN
initial amount: NaN
has only substance units: false
constant: false
type: Species
is encoded by: hsa:63917

http://identifiers.org/biomodels.db/MODEL1310110063#_41cba6bf_571a_4ee4_af2b_756cb494baca
is encoded by: hsa:83594
is: Q9BQG2
initial amount: NaN
initial concentration: NaN
name: NUDT12
type: Species
is: SBO:0000252
has only substance units: false
constant: false
boundary condition: true

metaR r1051
product: MODEL1310110063#
reactant: MODEL1310110063#
name: Vesicular transport
reversible: true
is described by: ECO:0000000
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:10772724,PMID:12856181 NOTES:
is: SBO:0000185
type: Reaction
kinetic law: MODEL1310110063#

metaR C3STDH1Pr
fast: false
product: MODEL1310110063#
modifier: MODEL1310110063#
notes: GENE_ASSOCIATION: (50814.1) SUBSYSTEM: Cholesterol metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:10710235,PMID:14506130 NOTES:NCD ER version NJ
kinetic law: MODEL1310110063#
reactant: MODEL1310110063#
type: Reaction
name: C-3 sterol dehydrogenase (4-methylzymosterol)
reversible: false
is described by: ECO:0000134
is version of: http://identifiers.org/ec-code/1.1.1.170
is: SBO:0000176

metaR r0384
kinetic law: MODEL1310110063#
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 1.2.4.2 Confidence Level: 0 AUTHORS: PMID:10676873 NOTES:
type: Reaction
fast: false
reactant: MODEL1310110063#
reversible: false
is described by: ECO:0000000
product: MODEL1310110063#
is: SBO:0000176
name: 2-oxoglutarate:[dihydrolipoyllysine-residue succinyltransferase]-lipoyllysine 2-oxidoreductase (decarboxylating, acceptor-succinylating) EC:1.2.4.2

metaR PI4P3K
name: phosphatidylinositol 4-phosphate 3-kinase
reactant: MODEL1310110063#
type: Reaction
is: SBO:0000176
notes: GENE_ASSOCIATION: (5291.1 and 5295.3) or (5296.1 and 5290.1) or (5293.1 and 5296.1) or (5287.1) or (5286.1) or (5293.1 and 8503.1) or (5293.1 and 5295.3) or (5291.1 and 8503.1) or (5295.2 and 5290.1) or (5288.1) or (5291.1 and 5295.1) or (5296.1 and 5291.1) or (23533.1 and 5294.1) or (5293.1 and 5295.1) or (5295.2 and 5293.1) or (5290.1 and 8503.1) or (5290.1 and 5295.3) or (10870.1 and 5294.1) or (5295.2 and 5291.1) or (5290.1 and 5295.1) SUBSYSTEM: Inositol phosphate metabolism EC Number: 2.7.1.68 Confidence Level: 4 AUTHORS: PMID:7624799,PMID:7713498,PMID:8246984,PMID:9113989,PMID:9337861,PMID:9830063,PMID:9878262 NOTES:NCD Notice that contrary to some standards in texts, KEGG, etc, the Rtotal group accounts for the whole fatty acyl CoA (so the CHO only accounts for the core backbone), manner in which Rtotal was produced accounts for O and H balances. Formation of the Rtotal group (rxn flux)accounted for mass balance for CoA NJ changed EC from 2.7.1.149 (pail5p) to 2.7.1.68 (pail4p) - NCD
kinetic law: MODEL1310110063#
modifier: MODEL1310110063#
is version of: http://identifiers.org/ec-code/2.7.1.154
reversible: false
is version of: http://identifiers.org/ec-code/2.7.1.153
fast: false
product: MODEL1310110063#
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/2.7.11.1

metaR r2096
reversible: true
kinetic law: MODEL1310110063#
fast: false
reactant: MODEL1310110063#
is described by: ECO:0000000
modifier: MODEL1310110063#
type: Reaction
product: MODEL1310110063#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
is: SBO:0000185

metaR r0753
modifier: MODEL1310110063#
type: Reaction
notes: GENE_ASSOCIATION: (2194.1) SUBSYSTEM: Unassigned EC Number: 1.2.1.5 Confidence Level: 0 AUTHORS: PMID:11790142,PMID:12604221 NOTES:
reactant: MODEL1310110063#
name: 3,4-Dihydroxymandelaldehyde:NADP+ oxidoreductase Tyrosine metabolism EC:1.2.1.5
is version of: http://identifiers.org/ec-code/2.3.1.85
reversible: true
is: SBO:0000176
product: MODEL1310110063#
fast: false
is described by: ECO:0000000
kinetic law: MODEL1310110063#

metaM ocdca c
initial amount: NaN
is: SBO:0000247
notes: FORMULA: C18H35O2 CHARGE: -1 INCHI: InChI=1S/C18H36O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20/h2-17H2,1H3,(H,19,20)/p-1 EHMN_ABBREVIATION: C01530
has only substance units: false
is: HMDB00827
initial concentration: 1.0
boundary condition: false
is: CHEBI:25629
name: stearate
constant: false
type: Species

metaM bamppald c
has only substance units: false
type: Species
initial amount: NaN
is: http://identifiers.org/pubchem.compound/7975
is: HMDB01106
is: C05665
constant: false
name: beta-Aminopropion aldehyde
notes: FORMULA: C3H8NO CHARGE: 1 INCHI: InChI=1/C3H7NO/c4-2-1-3-5/h3H,1-2,4H2 EHMN_ABBREVIATION: C05665
boundary condition: false
is: SBO:0000247
initial concentration: 1.0

metaR PYDXNK
product: MODEL1310110063#
is version of: http://identifiers.org/ec-code/2.7.1.35
reactant: MODEL1310110063#
notes: GENE_ASSOCIATION: (8566.1) SUBSYSTEM: Vitamin B6 metabolism EC Number: Confidence Level: 4 AUTHORS: NOTES:
reversible: false
is described by: ECO:0000269
fast: false
modifier: MODEL1310110063#
is: SBO:0000176
name: pyridoxine kinase
type: Reaction
kinetic law: MODEL1310110063#

metaR HPDCACRNt
type: Reaction
reversible: false
product: MODEL1310110063#
notes: GENE_ASSOCIATION: (788.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: PMID:14598172 NOTES:NJ
kinetic law: MODEL1310110063#
modifier: MODEL1310110063#
is described by: ECO:0000269
is: SBO:0000185
reactant: MODEL1310110063#
name: heptadecanoate transport into the mitochondria
fast: false

http://identifiers.org/biomodels.db/MODEL1310110063#_1d766fe3_3582_4b0d_be26_7ff221daf20c
has only substance units: false
type: Species
name: DCK
boundary condition: true
is: SBO:0000252
is: P27707
constant: false
initial concentration: NaN
is encoded by: hsa:1633
initial amount: NaN

metaM thr L c
initial concentration: 1.0
is: CHEBI:16857
is: HMDB00167
notes: FORMULA: C4H9NO3 CHARGE: 0 INCHI: InChI=1S/C4H9NO3/c1-2(6)3(5)4(7)8/h2-3,6H,5H2,1H3,(H,7,8)/t2-,3+/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00179
boundary condition: false
type: Species
is: SBO:0000247
name: L-threonine
constant: false
initial amount: NaN
has only substance units: false

metaM gal1p c
is: CHEBI:58336
is: HMDB00645
type: Species
constant: false
initial concentration: 1.0
has only substance units: false
notes: FORMULA: C6H11O9P CHARGE: -2 INCHI: InChI=1S/C6H13O9P/c7-1-2-3(8)4(9)5(10)6(14-2)15-16(11,12)13/h2-10H,1H2,(H2,11,12,13)/p-2/t2-,3+,4+,5-,6-/m1/s1 EHMN_ABBREVIATION: C00446
boundary condition: false
initial amount: NaN
name: (2R,3R,4S,5R,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl phosphate
is: SBO:0000247

metaR MTHFD2
reactant: MODEL1310110063#
product: MODEL1310110063#
is described by: ECO:0000134
reversible: true
kinetic law: MODEL1310110063#
modifier: MODEL1310110063#
is: SBO:0000176
fast: false
is version of: http://identifiers.org/ec-code/3.5.4.9
type: Reaction
notes: GENE_ASSOCIATION: (100287639.1) or (441024.1) SUBSYSTEM: Folate metabolism EC Number: 1.5.1.5 Confidence Level: 2 AUTHORS: PMID:2786332 NOTES:NCD
name: methylenetetrahydrofolate dehydrogenase (NAD)

metaR EX maltpt LPAREN e RPAREN
kinetic law: MODEL1310110063#
reactant: MODEL1310110063#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: maltopentaose exchange
type: Reaction

metaR r0921
reactant: MODEL1310110063#
fast: false
is: SBO:0000185
is described by: ECO:0000000
name: Postulated transport reaction
reversible: false
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:12006583,PMID:1260500,PMID:12838422,PMID:14747464,PMID:16595656,PMID:168203,PMID:17187757,PMID:17279066,PMID:3728675,PMID:6778226,PMID:7419607,PMID:7479738,PMID:8438778 NOTES:
kinetic law: MODEL1310110063#
product: MODEL1310110063#

http://identifiers.org/biomodels.db/MODEL1310110063#_5af40291_609b_4a73_8913_c2a3cd2b7869
has only substance units: false
is encoded by: hsa:3155
initial concentration: NaN
constant: false
boundary condition: true
type: Species
name: HMGCL
is: SBO:0000252
is: Q6IBC0
initial amount: NaN

metaM c10dc c
is: SBO:0000247
initial concentration: 1.0
has only substance units: false
name: sebacoyl carnitine
notes: FORMULA: C17H30NO6 CHARGE: -1
boundary condition: false
initial amount: NaN
type: Species
is: HMDB00651
constant: false

http://identifiers.org/biomodels.db/MODEL1310110063#_a5c2a887_c067_42fe_91f2_364e5e0a810a
constant: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
boundary condition: true
is: SBO:0000252
type: Species
is encoded by: hsa:18
name: ABAT

metaR r2097
fast: false
product: MODEL1310110063#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
is described by: ECO:0000000
modifier: MODEL1310110063#
is: SBO:0000185
reactant: MODEL1310110063#
type: Reaction
kinetic law: MODEL1310110063#
reversible: true

metaR DNDPt36m
reversible: false
reactant: MODEL1310110063#
name: dGDP transport via dCDP antiport
modifier: MODEL1310110063#
fast: false
is: SBO:0000185
product: MODEL1310110063#
notes: GENE_ASSOCIATION: (60386.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:11226231 NOTES:IT
type: Reaction
kinetic law: MODEL1310110063#
is described by: ECO:0000269

metaR RE3005M
modifier: MODEL1310110063#
reversible: true
is version of: http://identifiers.org/ec-code/4.2.1.107
fast: false
is described by: ECO:0000000
reactant: MODEL1310110063#
type: Reaction
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.1.1.35
notes: GENE_ASSOCIATION: (3295.1) or (1962.1) or (3033.1) or (3028.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.1.1.35 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:7775433 NOTES:
kinetic law: MODEL1310110063#
product: MODEL1310110063#
name: RE3005

metaR r0752
is described by: ECO:0000000
reactant: MODEL1310110063#
product: MODEL1310110063#
fast: false
type: Reaction
modifier: MODEL1310110063#
kinetic law: MODEL1310110063#
notes: GENE_ASSOCIATION: (30.1) or (10449.1) or (3032.1) or (4645.1) SUBSYSTEM: Unassigned EC Number: 1.2.1.5 Confidence Level: 0 AUTHORS: PMID:10424772,PMID:11958479,PMID:3466164 NOTES:
is version of: http://identifiers.org/ec-code/2.3.1.16
name: 3,4-Dihydroxymandelaldehyde:NAD+ oxidoreductase Tyrosine metabolism EC:1.2.1.5
reversible: true
is: SBO:0000176

metaM cytd c
initial amount: NaN
constant: false
has only substance units: false
is: HMDB00089
type: Species
notes: FORMULA: C9H13N3O5 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00381 EHMN_ABBREVIATION: C00475
boundary condition: false
is: SBO:0000247
is: C00475
is: CHEBI:17562
initial concentration: 1.0
name: Cytidine

metaR SERGLNNaEx
notes: GENE_ASSOCIATION: (6510.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14530974 NOTES:SAB see Kanai and Hediger 2004 (2003), PMID 14530974
name: L-serine/L-glutamine Na-dependent exchange (Ser-L in)
reactant: MODEL1310110063#
kinetic law: MODEL1310110063#
is described by: ECO:0000269
type: Reaction
modifier: MODEL1310110063#
reversible: false
fast: false
product: MODEL1310110063#
is: SBO:0000185

metaR ACCOAC
kinetic law: MODEL1310110063#
product: MODEL1310110063#
reactant: MODEL1310110063#
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: false
name: acetyl-CoA carboxylase
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110063#_900b6667_5d51_4d11_9ef8_0219d739264f
name: _AV727634_1_c
is encoded by: hsa:AV727634
is: SBO:0000252
initial amount: NaN
type: Species
initial concentration: NaN
constant: false
boundary condition: true
has only substance units: false

metaR FAOXC5C5OHm
kinetic law: MODEL1310110063#
product: MODEL1310110063#
reactant: MODEL1310110063#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C5-->C5OH)m
type: Reaction

metaR r2098
reactant: MODEL1310110063#
kinetic law: MODEL1310110063#
is described by: ECO:0000000
modifier: MODEL1310110063#
fast: false
product: MODEL1310110063#
type: Reaction
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
reversible: true
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
is: SBO:0000185

metaM 3oddcoa m
notes: FORMULA: C33H52N7O18P3S CHARGE: -4 INCHI: InChI=1S/C33H56N7O18P3S/c1-4-5-6-7-8-9-10-11-21(41)16-24(43)62-15-14-35-23(42)12-13-36-31(46)28(45)33(2,3)18-55-61(52,53)58-60(50,51)54-17-22-27(57-59(47,48)49)26(44)32(56-22)40-20-39-25-29(34)37-19-38-30(25)40/h19-20,22,26-28,32,44-45H,4-18H2,1-3H3,(H,35,42)(H,36,46)(H,50,51)(H,52,53)(H2,34,37,38)(H2,47,48,49)/t22-,26-,27-,28+,32-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01402 EHMN_ABBREVIATION: C05263
type: Species
initial amount: NaN
is: SBO:0000247
is: HMDB03937
constant: false
initial concentration: 1.0
is: CHEBI:27868
boundary condition: false
has only substance units: false
name: 3-Oxododecanoyl-CoA

http://identifiers.org/biomodels.db/MODEL1310110063#_fb719dd5_99bd_4cc3_9ea1_f9601a78b9b8
initial concentration: NaN
name: HK1
type: Species
boundary condition: true
is encoded by: hsa:3098
is: SBO:0000252
constant: false
has only substance units: false
is: Q59FD4
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110063#_a3e95ec7_9f4e_4223_856b_6e4077eddd9c
is encoded by: hsa:3032
is: SBO:0000252
constant: false
type: Species
name: HADHB
boundary condition: true
initial amount: NaN
has only substance units: false
is: P55084
initial concentration: NaN

metaM docohexcoa x
type: Species
initial concentration: 1.0
has only substance units: false
is: SBO:0000247
initial amount: NaN
constant: false
notes: FORMULA: C43H62N7O17P3S CHARGE: -4
is: http://identifiers.org/pubchem.compound/24892790
name: 2,4,7,10,13,16-docosahexenoylcoa
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110063#_7dd4e2ad_48cc_4496_819b_cc5eacdf3db5
boundary condition: true
constant: false
is encoded by: hsa:53354
is: SBO:0000252
name: PANK1
initial amount: NaN
initial concentration: NaN
type: Species
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110063#_a05e0245_86ee_4a1e_93a8_2b234371dc7f
is: P56556
is encoded by: hsa:4700
name: NDUFA6
initial amount: NaN
is: SBO:0000252
initial concentration: NaN
constant: false
type: Species
has only substance units: false
boundary condition: true

metaM ksi deg21 l
initial amount: NaN
is: CHEBI:12936
has only substance units: false
initial concentration: 1.0
type: Species
constant: false
boundary condition: false
is: SBO:0000247
notes: FORMULA: C132H213N9O114S6 CHARGE: -6
is: HMDB00143
name: keratan sulfate I, degradation product 21

metaR r0392
name: D-Glyceraldehyde:NAD+ oxidoreductase Glycerolipid metabolism EC:1.2.1.3
type: Reaction
reactant: MODEL1310110063#
fast: false
is described by: ECO:0000000
kinetic law: MODEL1310110063#
reversible: true
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 1.2.1.3 Confidence Level: 0 AUTHORS: PMID:12705826,PMID:170276,PMID:6189823,PMID:6285247,PMID:8155713 NOTES:
product: MODEL1310110063#

metaR r2092
is: SBO:0000185
modifier: MODEL1310110063#
reactant: MODEL1310110063#
reversible: true
product: MODEL1310110063#
kinetic law: MODEL1310110063#
is described by: ECO:0000000
fast: false
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
type: Reaction

metaR MECOAS1m
notes: GENE_ASSOCIATION: (8802.1 and 8801.1) SUBSYSTEM: C5-branched dibasic acid metabolism EC Number: 6.2.1.4 Confidence Level: 2 AUTHORS: PMID:13783048 NOTES:IF
is version of: http://identifiers.org/ec-code/6.2.1.4
is: SBO:0000176
is described by: ECO:0000304
type: Reaction
fast: false
reactant: MODEL1310110063#
name: mesaconate--CoA ligase (GDP-forming)
modifier: MODEL1310110063#
product: MODEL1310110063#
reversible: true
kinetic law: MODEL1310110063#

http://identifiers.org/biomodels.db/MODEL1310110063#_1eb09751_1137_421c_9f68_86368fee2ab4
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:5332
has only substance units: false
is: E2QRH8
constant: false
boundary condition: true
type: Species
is: SBO:0000252
name: PLCB4

http://identifiers.org/biomodels.db/MODEL1310110063#_adbe6a82_989d_4b89_9d16_1b2410bbbf36
is encoded by: hsa:5277
boundary condition: true
type: Species
initial amount: NaN
name: PIGA
constant: false
initial concentration: NaN
has only substance units: false
is: SBO:0000252

metaR EX leuktrD4 LPAREN e RPAREN
kinetic law: MODEL1310110063#
reactant: MODEL1310110063#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: leukotriene D4 exchange
type: Reaction

metaR RE1525M
modifier: MODEL1310110063#
notes: GENE_ASSOCIATION: (3295.1) or (1962.1) or (3033.1) or (3028.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.1.1.35 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:7775433 NOTES:
reactant: MODEL1310110063#
type: Reaction
kinetic law: MODEL1310110063#
fast: false
is version of: http://identifiers.org/ec-code/4.2.1.107
is described by: ECO:0000000
reversible: true
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.1.1.35
name: RE1525
product: MODEL1310110063#

metaM dgchol x
is: HMDB00637
has only substance units: false
is: CHEBI:36252
name: glycochenodeoxycholate
is: SBO:0000247
initial concentration: 1.0
notes: FORMULA: C26H43NO5 CHARGE: 0 INCHI: InChI=1S/C26H43NO5/c1-15(4-7-22(30)27-14-23(31)32)18-5-6-19-24-20(9-11-26(18,19)3)25(2)10-8-17(28)12-16(25)13-21(24)29/h15-21,24,28-29H,4-14H2,1-3H3,(H,27,30)(H,31,32)/p-1/t15-,16+,17-,18-,19+,20+,21-,24+,25+,26-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01472
type: Species
initial amount: NaN
constant: false
boundary condition: false

metaR DAG HSter
reactant: MODEL1310110063#
reversible: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: NOTES:
product: MODEL1310110063#
kinetic law: MODEL1310110063#
is: SBO:0000185
type: Reaction
is described by: ECO:0000000
fast: false
name: diacylglycerol ER export

metaR r2001
is: SBO:0000185
modifier: MODEL1310110063#
reactant: MODEL1310110063#
type: Reaction
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.15
reversible: false
fast: false
kinetic law: MODEL1310110063#
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is described by: ECO:0000000
product: MODEL1310110063#

metaR r0915
kinetic law: MODEL1310110063#
reactant: MODEL1310110063#
reversible: true
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:16919238,PMID:17173541,PMID:18406340,PMID:8132483 NOTES:
is: SBO:0000185
product: MODEL1310110063#
type: Reaction
fast: false
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2

metaR r0393
is: SBO:0000176
modifier: MODEL1310110063#
reactant: MODEL1310110063#
fast: false
kinetic law: MODEL1310110063#
notes: GENE_ASSOCIATION: (1633.1) SUBSYSTEM: Unassigned EC Number: 1.2.1.3 Confidence Level: 0 AUTHORS: PMID:12705826,PMID:170276,PMID:6189823,PMID:6285247,PMID:8155713 NOTES:
is version of: http://identifiers.org/ec-code/2.7.1.74
name: D-Glyceraldehyde:NAD+ oxidoreductase Glycerolipid metabolism EC:1.2.1.3
type: Reaction
is described by: ECO:0000000
reversible: false
product: MODEL1310110063#

metaM nh4 x
is: C01342
notes: FORMULA: H4N CHARGE: 1 HEPATONET_1.0_ABBREVIATION: HC00765 EHMN_ABBREVIATION: C01342
type: Species
boundary condition: false
constant: false
initial amount: NaN
is: HMDB00051
is: CHEBI:28938
is: SBO:0000247
name: Ammonium
initial concentration: 1.0
has only substance units: false

metaM ksi e
initial concentration: 1.0
constant: false
is: SBO:0000247
initial amount: NaN
notes: FORMULA: C247H393N17O213S12X CHARGE: -13
is: HMDB00211
name: keratan sulfate I
type: Species
is: CHEBI:17268
has only substance units: false
boundary condition: false

metaR FADH2tru
reversible: false
product: MODEL1310110063#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: NOTES:diffusion - but unidirectional uptake into ER (to avoid loops w/ NAD/NADP) NJ
kinetic law: MODEL1310110063#
name: FADH2 transporter, endoplasmic reticulum
is described by: ECO:0000000
fast: false
type: Reaction
reactant: MODEL1310110063#
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110063#_3d3041cc_1531_473b_9063_35c723c362cf
name: CA7
type: Species
boundary condition: true
is: Q86YU0
is encoded by: hsa:766
constant: false
initial concentration: NaN
has only substance units: false
initial amount: NaN
is: SBO:0000252

metaM crn c
constant: false
is: SBO:0000247
name: L-Carnitine
is: C00318
is: CHEBI:16347
is: HMDB00062
initial amount: NaN
initial concentration: 1.0
boundary condition: false
has only substance units: false
notes: FORMULA: C7H15NO3 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00270 EHMN_ABBREVIATION: C00318
type: Species

metaM pap g
initial amount: NaN
is: HMDB00061
notes: FORMULA: C10H11N5O10P2 CHARGE: -4 INCHI: InChI=1S/C10H15N5O10P2/c11-8-5-9(13-2-12-8)15(3-14-5)10-6(16)7(25-27(20,21)22)4(24-10)1-23-26(17,18)19/h2-4,6-7,10,16H,1H2,(H2,11,12,13)(H2,17,18,19)(H2,20,21,22)/p-4/t4-,6-,7-,10-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00059 EHMN_ABBREVIATION: C00054
initial concentration: 1.0
name: adenosine 3',5'-bismonophosphate(4-)
is: CHEBI:58343
type: Species
constant: false
boundary condition: false
has only substance units: false
is: SBO:0000247

metaR r2091
reactant: MODEL1310110063#
type: Reaction
product: MODEL1310110063#
kinetic law: MODEL1310110063#
fast: false
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
modifier: MODEL1310110063#
reversible: true
is: SBO:0000185
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110063#_d007e40a_8c90_42fc_bcdf_6db91609d10e
is: GO:0005739
is: SBO:0000290
constant: false
size: 1.0
spatial dimensions: 3.0
name: mitochondrion
type: Compartment

http://identifiers.org/biomodels.db/MODEL1310110063#_946564a4_aa31_4558_8f76_085324d27377
is: SBO:0000252
name: SLC24A4
has only substance units: false
is: Q8NFF2
initial concentration: NaN
is encoded by: hsa:123041
constant: false
initial amount: NaN
type: Species
boundary condition: true

metaR r0791
product: MODEL1310110063#
type: Reaction
is: SBO:0000176
notes: GENE_ASSOCIATION: (1962.1) or (3033.1) or (3028.1) or (3295.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.1.38 Confidence Level: 0 AUTHORS: PMID:12654921 NOTES:
reversible: true
reactant: MODEL1310110063#
modifier: MODEL1310110063#
is described by: ECO:0000000
name: trans-Hex-2-enoyl-CoA reductase Fatty acid elongation in mitochondria EC:1.3.1.38
fast: false
kinetic law: MODEL1310110063#
is version of: http://identifiers.org/ec-code/4.2.1.107
is version of: http://identifiers.org/ec-code/1.1.1.35

metaR PROSTGE2t2
product: MODEL1310110063#
modifier: MODEL1310110063#
reversible: true
notes: GENE_ASSOCIATION: (6582.2) or (6582.1) or (6580.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12827517,PMID:12883891,PMID:9187257 NOTES:electrogenic, Na indepdendent & rev NJ
is described by: ECO:0000269
type: Reaction
is: SBO:0000185
reactant: MODEL1310110063#
fast: false
name: prostaglandin uniport
kinetic law: MODEL1310110063#

metaM thyox L c
has only substance units: false
initial amount: NaN
constant: false
is: CHEBI:18332
boundary condition: false
initial concentration: 1.0
type: Species
notes: FORMULA: C15H11I4NO4 CHARGE: 0 INCHI: InChI=1S/C15H11I4NO4/c16-8-4-7(5-9(17)13(8)21)24-14-10(18)1-6(2-11(14)19)3-12(20)15(22)23/h1-2,4-5,12,21H,3,20H2,(H,22,23)/t12-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00849
is: HMDB00248
name: L-thyroxine
is: SBO:0000247

metaR MG1er
is version of: http://identifiers.org/ec-code/3.2.1.106
modifier: MODEL1310110063#
reactant: MODEL1310110063#
product: MODEL1310110063#
notes: GENE_ASSOCIATION: (7841.1) SUBSYSTEM: N-glycan synthesis EC Number: 3.2.1.106 Confidence Level: 0 AUTHORS: NOTES:NCD
reversible: false
type: Reaction
fast: false
is described by: ECO:0000000
is: SBO:0000176
name: mannosyl-oligosaccharide glucosidase, endoplasmic reticulum
kinetic law: MODEL1310110063#

metaR GGT6
is described by: ECO:0000000
fast: false
reactant: MODEL1310110063#
reversible: true
is: SBO:0000176
product: MODEL1310110063#
notes: GENE_ASSOCIATION: SUBSYSTEM: Eicosanoid metabolism EC Number: 2.3.2.2 Confidence Level: 2 AUTHORS: PMID:12729612 NOTES:Converts leukotriene E4 (LTE4) to leukotriene D4 (LTE4). NJ
type: Reaction
kinetic law: MODEL1310110063#
name: Gamma-glutamyltransferase

http://identifiers.org/biomodels.db/MODEL1310110063#_d66fe0b8_b089_49df_9704_77c13e09a2b2
constant: false
initial amount: NaN
initial concentration: NaN
type: Species
boundary condition: true
has only substance units: false
name: ATP5D
is: SBO:0000252
is encoded by: hsa:513

metaR GLCNACASE4ly
notes: GENE_ASSOCIATION: (4669.1) SUBSYSTEM: Heparan sulfate degradation EC Number: 3.2.1.50 Confidence Level: 4 AUTHORS: PMID:1783617,PMID:8776591,PMID:8993162 NOTES:NCD
is version of: http://identifiers.org/ec-code/3.2.1.50
is: SBO:0000176
kinetic law: MODEL1310110063#
reactant: MODEL1310110063#
fast: false
product: MODEL1310110063#
modifier: MODEL1310110063#
reversible: false
is described by: ECO:0000000
name: alpha-N-acetylglucosaminidase, lysosomal
type: Reaction

metaR EX pheacgln LPAREN e RPAREN
kinetic law: MODEL1310110063#
reactant: MODEL1310110063#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: alpha-N-Phenylacetyl-L-glutamine exchange
type: Reaction

metaR r0390
kinetic law: MODEL1310110063#
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 3.2.1.10 Confidence Level: 0 AUTHORS: PMID:17194452 NOTES:
product: MODEL1310110063#
type: Reaction
reactant: MODEL1310110063#
is described by: ECO:0000000
is: SBO:0000176
reversible: true
fast: false
name: Isomaltose 6-alpha-D-glucanohydrolase Starch and sucrose metabolism EC:3.2.1.10

metaR r2094
product: MODEL1310110063#
fast: false
reactant: MODEL1310110063#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
type: Reaction
kinetic law: MODEL1310110063#
is: SBO:0000185
reversible: true
modifier: MODEL1310110063#

metaM c3dc e
notes: FORMULA: C10H16NO6 CHARGE: -1
is: SBO:0000247
initial amount: NaN
boundary condition: false
name: malonyl carnitine
constant: false
has only substance units: false
initial concentration: 1.0
is: HMDB02095
type: Species

http://identifiers.org/biomodels.db/MODEL1310110063#_fd095271_4523_4708_b50b_7fa1bb408461
boundary condition: true
is: P49189
has only substance units: false
type: Species
initial concentration: NaN
name: ALDH9A1
is encoded by: hsa:223
initial amount: NaN
is: SBO:0000252
constant: false

metaR S6T13g
kinetic law: MODEL1310110063#
reversible: false
notes: GENE_ASSOCIATION: (4166.1) or (10164.1) or (23563.2) or (23563.1) or (9435.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: Confidence Level: 4 AUTHORS: PMID:10330415,PMID:10491328,PMID:10913333,PMID:11278593,PMID:12403612,PMID:12855678,PMID:9722682 NOTES:NCD
fast: false
type: Reaction
product: MODEL1310110063#
is: SBO:0000176
reactant: MODEL1310110063#
is described by: ECO:0000000
modifier: MODEL1310110063#
name: galactose/N-acetylglucosamine 6-O-sulfotransferase, Golgi apparatus

http://identifiers.org/biomodels.db/MODEL1310110063#_cd85466d_8602_4b93_9bc7_25178cf325dc
has part: P25705
type: Species
is encoded by: hsa:509
initial concentration: NaN
has only substance units: false
is: SBO:0000297
constant: false
initial amount: NaN
boundary condition: true
has part: Q6I9V2
is encoded by: hsa:498
name: ATP5A1:ATP5B:ATP5C1:ATP5D:ATP5E

http://identifiers.org/biomodels.db/MODEL1310110063#_7041beda_6c54_4019_8d22_033ad2c32443
is: SBO:0000252
boundary condition: true
is encoded by: hsa:65263
has only substance units: false
initial concentration: NaN
type: Species
initial amount: NaN
is: Q53H96
name: PYCRL
constant: false

metaR r0792
modifier: MODEL1310110063#
name: 5-methyltetrahydrofolate:NAD+ oxidoreductase One carbon pool by folate / Methane metabolism EC:1.5.1.20
is: SBO:0000176
is version of: http://identifiers.org/ec-code/4.2.1.107
product: MODEL1310110063#
is described by: ECO:0000000
reactant: MODEL1310110063#
kinetic law: MODEL1310110063#
fast: false
reversible: true
notes: GENE_ASSOCIATION: (3295.1) SUBSYSTEM: Folate metabolism EC Number: 1.5.1.20 Confidence Level: 0 AUTHORS: PMID:1119805,PMID:2383427 NOTES:
type: Reaction

metaR SIAT4Bg
type: Reaction
kinetic law: MODEL1310110063#
is described by: ECO:0000269
fast: false
is: SBO:0000176
product: MODEL1310110063#
reactant: MODEL1310110063#
reversible: false
name: Beta-galactoside alpha-2,3-sialyltransferase, Golgi apparatus
is version of: http://identifiers.org/ec-code/2.4.99.4
modifier: MODEL1310110063#
notes: GENE_ASSOCIATION: (6483.1) SUBSYSTEM: Sphingolipid metabolism EC Number: 2.4.99.4 Confidence Level: 4 AUTHORS: PMID:9266697 NOTES:NJ

http://identifiers.org/biomodels.db/MODEL1310110063#_3c9fe12f_ab71_42b8_a60c_313e9118a04a
is encoded by: hsa:374291
has part: O95168
constant: false
is encoded by: hsa:4722
has part: Q7GXZ4
has part: Q7GXZ1
is encoded by: hsa:4705
name: NDUFA11:NDUFS7:ND1:ND2:ND3:ND4:ND4L:ND5:ND6:NDUFA1:NDUFA2:NDUFA3:NDUFA4:NDUFA5:NDUFA6:NDUFA7:NDUFA8:NDUFA9:NDUFA10:NDUFAB1:NDUFB1:NDUFB2:NDUFB3:NDUFB4:NDUFB5:NDUFB6:NDUFB7:NDUFB8:NDUFB9:NDUFB10:NDUFC1:NDUFC2:NDUFS1:NDUFS2:NDUFS3:NDUFV1:NDUFS4:NDUFS5:NDUFS6:NDUFS8:NDUFV2:NDUFV3:NDUFA13:NDUFA12:TUSC3
is encoded by: hsa:4706
is encoded by: hsa:4536
is encoded by: hsa:4538
has part: Q6IBA0
has part: O00483
has part: Q6IBB5
is encoded by: hsa:4718
is encoded by: hsa:4539
is encoded by: hsa:4697
has part: P56181
is encoded by: hsa:51079
has part: P03915
is encoded by: hsa:4710
is encoded by: hsa:4719
has part: B7Z792
has part: Q7GXY9
has part: H7C5B8
is encoded by: hsa:4711
initial concentration: NaN
has part: O95167
has part: P03905
has part: P03897
is encoded by: hsa:126328
has part: O43678
has part: P17568
is encoded by: hsa:4731
has part: Q16795
has part: O95139
has part: O43181
is encoded by: hsa:4698
has part: P56556
is encoded by: hsa:4723
is encoded by: hsa:4715
is encoded by: hsa:4694
has part: Q6FG42
is encoded by: hsa:4724
is encoded by: hsa:4540
has part: Q9P0J0
is encoded by: hsa:4707
has part: A8K761
is encoded by: hsa:4708
boundary condition: true
has part: C9JT23
has part: O43677
is encoded by: hsa:4700
has part: O43674
has part: O00217
is encoded by: hsa:4712
has part: Q13454
is encoded by: hsa:4728
is encoded by: hsa:4713
is encoded by: hsa:7991
is encoded by: hsa:4720
has part: Q549M5
type: Species
is: SBO:0000297
has part: F8VQS7
initial amount: NaN
has part: Q16718
is encoded by: hsa:55967
has only substance units: false
has part: P28331
is encoded by: hsa:4704
has part: Q9Y6M9
has part: O95169
has part: Q85KV6
is encoded by: hsa:4541
is encoded by: hsa:4716
is encoded by: hsa:4535
is encoded by: hsa:4537
has part: B1AM93
is encoded by: hsa:4695

metaR FAOXC143C123m
kinetic law: MODEL1310110063#
product: MODEL1310110063#
reactant: MODEL1310110063#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C14:3-->C12:3)m
type: Reaction

metaM CE5116 x
name: trans-3-cis-8,11,14-eicosatetraenoyl-CoA
notes: FORMULA: C41H62N7O17P3S CHARGE: -4 INCHI: InChI=1/C41H66N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-32(50)69-25-24-43-31(49)22-23-44-39(53)36(52)41(2,3)27-62-68(59,60)65-67(57,58)61-26-30-35(64-66(54,55)56)34(51)40(63-30)48-29-47-33-37(42)45-28-46-38(33)48/h8-9,11-12,14-15,19-20,28-30,34-36,40,51-52H,4-7,10,13,16-18,21-27H2,1-3H3,(H,43,49)(H,44,53)(H,57,58)(H,59,60)(H2,42,45,46)(H2,54,55,56)/p-4/b9-8-,12-11-,15-14-,20-19+/t30-,34+,35+,36u,40-/m0/s1 EHMN_ABBREVIATION: CE5116
is: CHEBI:57923
has only substance units: false
initial concentration: 1.0
type: Species
initial amount: NaN
is: SBO:0000247
constant: false
boundary condition: false

metaR G14T3g
kinetic law: MODEL1310110063#
reversible: false
fast: false
is version of: http://identifiers.org/ec-code/2.4.1.38
reactant: MODEL1310110063#
product: MODEL1310110063#
notes: GENE_ASSOCIATION: (8703.1) or (2683.1) or (8704.2) or (8704.1) or (9334.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.38 Confidence Level: 4 AUTHORS: PMID:12512857,PMID:1903938,PMID:3094506,PMID:3144273,PMID:9405390,PMID:9435216 NOTES:Keratan sulfate II biosynthesis NCD
type: Reaction
is: SBO:0000176
name: beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase, Golgi
is version of: http://identifiers.org/ec-code/2.4.1.22
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/2.4.1.90
modifier: MODEL1310110063#

http://identifiers.org/biomodels.db/MODEL1310110063#_0cf6e506_a834_4072_87ba_33fe8b0ebe51
is encoded by: hsa:23057
type: Species
name: NMNAT2
initial concentration: NaN
constant: false
boundary condition: true
is: SBO:0000252
has only substance units: false
initial amount: NaN
is: Q9BZQ4

http://identifiers.org/biomodels.db/MODEL1310110063#_3cfdc6bc_4098_45c7_bc7b_c39e26e97a81
boundary condition: true
is: P48448
initial amount: NaN
constant: false
initial concentration: NaN
type: Species
is encoded by: hsa:222
has only substance units: false
is: SBO:0000252
name: ALDH3B2

metaM tetdec2coa c
is: HMDB02014
is: SBO:0000247
notes: FORMULA: C35H54N7O17P3S CHARGE: -4
boundary condition: false
constant: false
has only substance units: false
initial concentration: 1.0
initial amount: NaN
name: tetradecadienoylcoa
type: Species

metaR 5ADTSTSTERONESte
type: Reaction
reversible: true
kinetic law: MODEL1310110063#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 1 AUTHORS: NOTES:unknown mechanism - presumed excretion of sulfonated testosterone NJ
fast: false
name: sulfonated testosterone transport
reactant: MODEL1310110063#
is: SBO:0000185
product: MODEL1310110063#

metaR r0913
product: MODEL1310110063#
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:16919238,PMID:17173541,PMID:18406340,PMID:8132483 NOTES:
fast: false
reactant: MODEL1310110063#
is described by: ECO:0000000
reversible: true
is: SBO:0000185
kinetic law: MODEL1310110063#
type: Reaction

metaM glyc3p m
name: Glycerol 3-phosphate
type: Species
initial concentration: 1.0
is: CHEBI:57597
is: SBO:0000247
initial amount: NaN
boundary condition: false
is: C00093
notes: FORMULA: C3H7O6P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00095 EHMN_ABBREVIATION: C00093
is: HMDB00126
has only substance units: false
constant: false

metaR 2HCO3 NAt
product: MODEL1310110063#
reversible: true
kinetic law: MODEL1310110063#
notes: GENE_ASSOCIATION: (57835.3) or (8671.1) or (57835.2) or (57835.1) or (57835.4) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14722772 NOTES:MM
is: SBO:0000185
name: bicarbonate transport (Na/HCO3 1:2 cotransport)
modifier: MODEL1310110063#
reactant: MODEL1310110063#
is described by: ECO:0000269
fast: false
type: Reaction

metaR r2093
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
reversible: true
modifier: MODEL1310110063#
kinetic law: MODEL1310110063#
is: SBO:0000185
is described by: ECO:0000000
product: MODEL1310110063#
fast: false
reactant: MODEL1310110063#
type: Reaction

metaR r0391
is described by: ECO:0000000
is: SBO:0000176
kinetic law: MODEL1310110063#
product: MODEL1310110063#
reversible: true
name: Nicotinate D-ribonucleotide:pyrophosphate phosphoribosyltransferase Nicotinate and nicotinamide metabolism EC:2.4.2.11
reactant: MODEL1310110063#
notes: GENE_ASSOCIATION: SUBSYSTEM: NAD metabolism EC Number: 2.4.2.11 Confidence Level: 0 AUTHORS: PMID:17604275 NOTES:
type: Reaction
fast: false

metaR LEUTAm
is: SBO:0000176
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (587.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 2.6.1.6 Confidence Level: 4 AUTHORS: PMID:6933702,PMID:9165094 NOTES:NCD
fast: false
reversible: true
is version of: http://identifiers.org/ec-code/2.6.1.42
reactant: MODEL1310110063#
kinetic law: MODEL1310110063#
type: Reaction
modifier: MODEL1310110063#
name: leucine transaminase, mitochondrial
product: MODEL1310110063#

metaR 13DAMPPOX
modifier: MODEL1310110063#
is: SBO:0000176
kinetic law: MODEL1310110063#
product: MODEL1310110063#
is version of: http://identifiers.org/ec-code/1.4.3.22
type: Reaction
is version of: http://identifiers.org/ec-code/1.4.3.21
is described by: ECO:0000212
reversible: false
fast: false
reactant: MODEL1310110063#
name: 1,3-Diaminopropane:oxygen oxidoreductase (deaminating)
notes: GENE_ASSOCIATION: (8639.1) or (26.1) or (314.2) or (314.1) SUBSYSTEM: beta-Alanine metabolism EC Number: 1.4.3.6 Confidence Level: 1 AUTHORS: PMID:15035803,PMID:8920635,PMID:9653080 NOTES:SAB

http://identifiers.org/biomodels.db/MODEL1310110063#_2f73d889_74f4_4c5c_8a58_5731ca2cb875
is encoded by: hsa:349565
boundary condition: true
initial amount: NaN
is: Q96T66
name: NMNAT3
type: Species
has only substance units: false
is: SBO:0000252
initial concentration: NaN
constant: false

metaM retinol e
is: SBO:0000247
is: CHEBI:50211
constant: false
boundary condition: false
notes: FORMULA: C20H30O CHARGE: 0 INCHI: InChI=1S/C20H30O/c1-16(8-6-9-17(2)13-15-21)11-12-19-18(3)10-7-14-20(19,4)5/h6,8-9,11-13,21H,7,10,14-15H2,1-5H3
is: HMDB00305
name: retinol
initial concentration: 1.0
initial amount: NaN
type: Species
has only substance units: false

metaM ksi g
boundary condition: false
has only substance units: false
initial concentration: 1.0
notes: FORMULA: C247H393N17O213S12X CHARGE: -13
type: Species
name: keratan sulfate I
is: HMDB01644
constant: false
initial amount: NaN
is: SBO:0000247
is: CHEBI:17140

metaR r2437
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:1735445,PMID:18406340,PMID:1988962,PMID:2351134,PMID:2355017,PMID:6361812,PMID:7892212,PMID:8132483 NOTES:
reversible: false
type: Reaction
kinetic law: MODEL1310110063#
name: Mitochondrial Carrier (MC) TCDB:2.A.29.8.3
is described by: ECO:0000000
reactant: MODEL1310110063#
product: MODEL1310110063#
fast: false
is: SBO:0000185

metaM 3hexdtetcoa m
initial amount: NaN
notes: FORMULA: C37H54N7O17P3S CHARGE: -4
is: SBO:0000247
is: HMDB02288
has only substance units: false
name: 3,7,10,13-hexadecatetraenoylcoa
initial concentration: 1.0
boundary condition: false
constant: false
type: Species

metaR PGK
is described by: ECO:0000134
fast: false
is: SBO:0000176
reactant: MODEL1310110063#
modifier: MODEL1310110063#
reversible: true
kinetic law: MODEL1310110063#
notes: GENE_ASSOCIATION: (5230.1) or (375056.1) or (5232.1) SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: Confidence Level: 0 AUTHORS: NOTES:
type: Reaction
is version of: http://identifiers.org/ec-code/2.7.2.3
product: MODEL1310110063#
name: phosphoglycerate kinase

http://identifiers.org/biomodels.db/MODEL1310110063#_14de723f_dffb_4999_9286_a3e20f557fab
is: Q02846
boundary condition: true
is encoded by: hsa:3000
type: Species
initial amount: NaN
is: SBO:0000252
constant: false
name: GUCY2D
has only substance units: false
initial concentration: NaN

metaR MTHFCm
is version of: http://identifiers.org/ec-code/6.3.4.3
modifier: MODEL1310110063#
notes: GENE_ASSOCIATION: (25902.1) or (10797.1) SUBSYSTEM: Folate metabolism EC Number: 3.5.4.9 Confidence Level: 4 AUTHORS: PMID:12937168 NOTES:NCD
reversible: true
type: Reaction
product: MODEL1310110063#
kinetic law: MODEL1310110063#
is version of: http://identifiers.org/ec-code/3.5.4.9
is described by: ECO:0000269
name: methenyltetrahydrifikate cyclohydrolase, mitochondrial
is: SBO:0000176
fast: false
reactant: MODEL1310110063#

metaM CE5788 e
type: Species
is: CHEBI:27485
name: kinetensin 1-7
boundary condition: false
initial concentration: 1.0
notes: FORMULA: C41H67N15O9 CHARGE: 2 INCHI: InChI=1/C41H65N15O9/c1-4-22(2)32(42)37(62)51-23(3)33(58)52-27(8-5-15-48-40(43)44)34(59)53-28(9-6-16-49-41(45)46)35(60)54-29(19-25-20-47-21-50-25)38(63)56-17-7-10-31(56)36(61)55-30(39(64)65)18-24-11-13-26(57)14-12-24/h11-14,20-23,27-32,57H,4-10,15-19,42H2,1-3H3,(H,47,50)(H,51,62)(H,52,58)(H,53,59)(H,54,60)(H,55,61)(H,64,65)(H4,43,44,48)(H4,45,46,49)/p+2/t22-,23+,27-,28+,29-,30+,31-,32-/m1/s1 EHMN_ABBREVIATION: CE5788
initial amount: NaN
is: SBO:0000247
is: HMDB02710
constant: false
has only substance units: false

metaR r0055
product: MODEL1310110063#
reactant: MODEL1310110063#
is version of: http://identifiers.org/ec-code/2.4.2.7
modifier: MODEL1310110063#
name: 2-Oxopropanal:NADP+ oxidoreductase Pyruvate metabolism EC:1.2.1.49
kinetic law: MODEL1310110063#
fast: false
is: SBO:0000176
notes: GENE_ASSOCIATION: (353.1) or (3251.1) SUBSYSTEM: Pyruvate metabolism EC Number: 1.2.1.49 Confidence Level: 0 AUTHORS: PMID:20958,PMID:4383524,PMID:4391087,PMID:6014,PMID:7107625,PMID:7107626,PMID:7144586,PMID:7763257,PMID:7993370 NOTES:IT added 2 protons (are there really 2 protons produced?)
type: Reaction
reversible: true
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/2.4.2.8

metaM pap c
initial concentration: 1.0
initial amount: NaN
has only substance units: false
is: CHEBI:58343
is: HMDB00061
name: adenosine 3',5'-bismonophosphate(4-)
type: Species
is: SBO:0000247
boundary condition: false
constant: false
notes: FORMULA: C10H11N5O10P2 CHARGE: -4 INCHI: InChI=1S/C10H15N5O10P2/c11-8-5-9(13-2-12-8)15(3-14-5)10-6(16)7(25-27(20,21)22)4(24-10)1-23-26(17,18)19/h2-4,6-7,10,16H,1H2,(H2,11,12,13)(H2,17,18,19)(H2,20,21,22)/p-4/t4-,6-,7-,10-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00059 EHMN_ABBREVIATION: C00054

metaM retinol c
boundary condition: false
type: Species
notes: FORMULA: C20H30O CHARGE: 0 INCHI: InChI=1S/C20H30O/c1-16(8-6-9-17(2)13-15-21)11-12-19-18(3)10-7-14-20(19,4)5/h6,8-9,11-13,21H,7,10,14-15H2,1-5H3
constant: false
initial concentration: 1.0
is: CHEBI:50211
name: retinol
is: HMDB00305
has only substance units: false
initial amount: NaN
is: SBO:0000247

metaM 4ppan c
constant: false
type: Species
is: C03492
is: CHEBI:10986
notes: FORMULA: C9H15NO8P CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC01127 EHMN_ABBREVIATION: C03492
has only substance units: false
boundary condition: false
initial concentration: 1.0
is: SBO:0000247
name: D-4'-Phosphopantothenate
is: HMDB01016
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110063#_4ad12eb4_edc6_4b6f_ae94_1f8a809dc40e
is encoded by: hsa:7991
name: NDUFA11:NDUFS7:ND1:ND2:ND3:ND4:ND4L:ND5:ND6:NDUFA1:NDUFA2:NDUFA3:NDUFA4:NDUFA5:NDUFA6:NDUFA7:NDUFA8:NDUFA9:NDUFA10:NDUFAB1:NDUFB1:NDUFB2:NDUFB3:NDUFB4:NDUFB5:NDUFB6:NDUFB7:NDUFB8:NDUFB9:NDUFB10:NDUFC1:NDUFC2:NDUFS1:NDUFS2:NDUFS3:NDUFV1:NDUFS4:NDUFS5:NDUFS6:NDUFS8:NDUFV2:NDUFV3:NDUFA13:NDUFA12:TUSC3
initial concentration: NaN
type: Species
is: SBO:0000297
initial amount: NaN
boundary condition: true
has only substance units: false
constant: false

metaR EX pydx5p LPAREN e RPAREN
kinetic law: MODEL1310110063#
reactant: MODEL1310110063#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of pyridoxal 5-phosphate(2-)
type: Reaction

metaM 4mzym int2 r
is: HMDB06838
initial amount: NaN
constant: false
name: 4-Methylzymosterol intermediate 2
has only substance units: false
notes: FORMULA: C28H44O CHARGE: 0 INCHI: InChI=1/C28H44O/c1-18(2)8-7-9-19(3)22-12-13-24-21-10-11-23-20(4)26(29)15-17-28(23,6)25(21)14-16-27(22,24)5/h8,19-20,22-24H,7,9-17H2,1-6H3/t19-,20?,22?,23?,24?,27-,28+/m1/s1
type: Species
initial concentration: 1.0
is: SBO:0000247
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110063#_0f9fbed0_60bd_4b63_8ffb_e5fedfed98d0
constant: false
has only substance units: false
name: ALG5
initial concentration: NaN
is: Q9Y673
type: Species
boundary condition: true
is: SBO:0000252
is encoded by: hsa:29880
initial amount: NaN

metaR ATPtx
is: SBO:0000185
kinetic law: MODEL1310110063#
fast: false
product: MODEL1310110063#
is described by: ECO:0000000
reversible: true
name: ATP transporter, peroxisomal
reactant: MODEL1310110063#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 1 AUTHORS: NOTES:most likely NOT physiological - detailed information about the peroxisomal transporters has not yet been achieved - this transport is most likely dependent on a concomitant energy consuming reaction (human ABC peroxisomal transporters: PEX family - check in future for new research articles describing biochemistry and stoichiometry) NJ

http://identifiers.org/biomodels.db/MODEL1310110063#_3c70baeb_c7f8_4cb4_97eb_d2b4a7ea4bf3
is encoded by: hsa:113452
has only substance units: false
initial concentration: NaN
type: Species
initial amount: NaN
is: Q969K7
name: TMEM54
is: SBO:0000252
constant: false
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110063#_44925321_4edb_425b_9914_efbd3ceae966
has only substance units: false
is encoded by: hsa:27306
name: HPGDS
initial concentration: NaN
type: Species
constant: false
is: SBO:0000252
boundary condition: true
initial amount: NaN
is: O60760

metaR r2090
product: MODEL1310110063#
is: SBO:0000185
reactant: MODEL1310110063#
reversible: true
modifier: MODEL1310110063#
is described by: ECO:0000000
kinetic law: MODEL1310110063#
fast: false
type: Reaction
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
name: Major Facilitator(MFS) TCDB:2.A.1.13.1

metaR r0796
fast: false
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.2.1.5
product: MODEL1310110063#
name: Ribitol:NAD+ 2-oxidoreductase Pentose and glucuronate interconversions EC:1.1.1.56
is described by: ECO:0000000
reactant: MODEL1310110063#
reversible: true
modifier: MODEL1310110063#
kinetic law: MODEL1310110063#
type: Reaction
notes: GENE_ASSOCIATION: (220.1) or (218.1) or (221.1) or (222.1) or (U37519.1) SUBSYSTEM: Pentose phosphate pathway EC Number: Confidence Level: 0 AUTHORS: PMID:15234337 NOTES:

metaR NRVNCt
type: Reaction
product: MODEL1310110063#
is described by: ECO:0000000
kinetic law: MODEL1310110063#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11788354,PMID:12864740 NOTES:NJ
reversible: true
reactant: MODEL1310110063#
name: fatty acid transport via diffusion
is: SBO:0000185
fast: false

metaM ksii core4 deg3 l
is: SBO:0000247
constant: false
has only substance units: false
name: keratan sulfate II (core 4-linked), degradation product 3
notes: FORMULA: C66H107N6O51S2X CHARGE: -2
initial concentration: 1.0
is: CHEBI:12936
boundary condition: false
initial amount: NaN
type: Species
is: HMDB00143

metaR HEDCECRNe
kinetic law: MODEL1310110063#
product: MODEL1310110063#
reactant: MODEL1310110063#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of 3-hydroxyhexadecenoyl carnitine into extra cellular space
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110063#_bae30102_c751_4fb0_9ab7_c8058791b1d8
is: SBO:0000252
boundary condition: true
constant: false
has only substance units: false
is encoded by: hsa:1337
type: Species
is: P12074
name: COX6A1
initial amount: NaN
initial concentration: NaN

metaR EX dmhptcrn LPAREN e RPAREN
kinetic law: MODEL1310110063#
reactant: MODEL1310110063#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 2,6 dimethylheptanoyl carnitine exchange
type: Reaction

metaR PGI
type: Reaction
notes: GENE_ASSOCIATION: (2821.1) SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: 5.3.1.9 Confidence Level: 0 AUTHORS: PMID:19064002,PMID:2241164,PMID:8530082 NOTES:
fast: false
modifier: MODEL1310110063#
is described by: ECO:0000134
kinetic law: MODEL1310110063#
reversible: true
is: SBO:0000176
reactant: MODEL1310110063#
product: MODEL1310110063#
name: glucose-6-phosphate isomerase
is version of: http://identifiers.org/ec-code/5.3.1.9

http://identifiers.org/biomodels.db/MODEL1310110063#_053bb0d8_b99d_4ce9_9a8b_f8d75031603a
type: Species
is: P50993
initial amount: NaN
has only substance units: false
constant: false
boundary condition: true
initial concentration: NaN
is encoded by: hsa:477
name: ATP1A2
is: SBO:0000252

metaR HS3ly
fast: false
product: MODEL1310110063#
reactant: MODEL1310110063#
name: heparan-N-sulfatase, lysosomal
is described by: ECO:0000000
reversible: false
type: Reaction
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.10.1.1
modifier: MODEL1310110063#
kinetic law: MODEL1310110063#
notes: GENE_ASSOCIATION: (6448.1) SUBSYSTEM: Heparan sulfate degradation EC Number: 3.10.1.1 Confidence Level: 4 AUTHORS: PMID:7493035,PMID:8993162,PMID:9405287 NOTES:NCD

metaR CYTDK2m
name: cytidine kinase (ATP), mitochondrial
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 1 AUTHORS: NOTES:IT
reversible: false
is: SBO:0000176
reactant: MODEL1310110063#
type: Reaction
kinetic law: MODEL1310110063#
fast: false
product: MODEL1310110063#

metaR EX h2o2 LPAREN e RPAREN
kinetic law: MODEL1310110063#
reactant: MODEL1310110063#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Hydrogen peroxide exchange
type: Reaction

metaR RE3556C
kinetic law: MODEL1310110063#
name: RE3556
notes: GENE_ASSOCIATION: SUBSYSTEM: Eicosanoid metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:234423 NOTES:
reactant: MODEL1310110063#
fast: false
product: MODEL1310110063#
reversible: true
is described by: ECO:0000000
type: Reaction
is: SBO:0000176

metaM sebacid c
type: Species
notes: FORMULA: C10H16O4 CHARGE: -2
has only substance units: false
constant: false
is: SBO:0000247
boundary condition: false
name: sebacicacid
initial amount: NaN
is: C08277
is: HMDB00792
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110063#_844b53fb_2dee_4623_8cc9_90da61bc706e
boundary condition: true
name: SULT1A1
is encoded by: hsa:6817
initial amount: NaN
type: Species
is: SBO:0000252
constant: false
initial concentration: NaN
has only substance units: false

metaM HC01397 m
constant: false
is: SBO:0000247
has only substance units: false
name: (S)-3-Hydroxyhexadecanoyl-CoA
type: Species
boundary condition: false
is: CHEBI:27402
initial amount: NaN
initial concentration: 1.0
notes: FORMULA: C37H62N7O18P3S CHARGE: -4 INCHI: InChI=1S/C37H66N7O18P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-25(45)20-28(47)66-19-18-39-27(46)16-17-40-35(50)32(49)37(2,3)22-59-65(56,57)62-64(54,55)58-21-26-31(61-63(51,52)53)30(48)36(60-26)44-24-43-29-33(38)41-23-42-34(29)44/h23-26,30-32,36,45,48-49H,4-22H2,1-3H3,(H,39,46)(H,40,50)(H,54,55)(H,56,57)(H2,38,41,42)(H2,51,52,53)/t25-,26+,30+,31+,32-,36+/m0/s1 EHMN_ABBREVIATION: C05258

metaR ATPS4m
product: MODEL1310110063#
kinetic law: MODEL1310110063#
is described by: ECO:0000134
type: Reaction
is version of: http://identifiers.org/ec-code/3.6.3.14
modifier: MODEL1310110063#
name: ATP synthase (four protons for one ATP)
is version of: http://identifiers.org/ec-code/3.6.4.6
notes: GENE_ASSOCIATION: (513.1 and 498.2 and 506.1 and 509.2 and 514.1 or 498.2 and 513.2 and 514.2 and 506.1 and 509.2 or 513.1 and 509.1 and 498.1 and 514.2 and 506.1 or 498.2 and 513.2 and 506.1 and 509.2 and 514.1 or 513.2 and 498.1 and 514.2 and 506.1 and 509.2 or 513.1 and 498.1 and 506.1 and 509.2 and 514.1 or 513.1 and 498.2 and 514.2 and 506.1 and 509.2 or 513.1 and 498.2 and 509.1 and 506.1 and 514.1 or 498.2 and 509.1 and 513.2 and 506.1 and 514.1 or 513.2 and 498.1 and 506.1 and 509.2 and 514.1 or 513.2 and 514.2 and 506.1 and 509.2 and 498.3 or 513.2 and 506.1 and 509.2 and 498.3 and 514.1 or 513.1 and 509.1 and 506.1 and 498.3 and 514.1 or 509.1 and 513.2 and 514.2 and 506.1 and 498.3 or 513.1 and 498.2 and 509.1 and 514.2 and 506.1 or 513.1 and 498.1 and 514.2 and 506.1 and 509.2 or 513.1 and 509.1 and 498.1 and 506.1 and 514.1 or 513.1 and 506.1 and 509.2 and 498.3 and 514.1 or 509.1 and 513.2 and 506.1 and 498.3 and 514.1 or 513.1 and 514.2 and 506.1 and 509.2 and 498.3 or 509.1 and 513.2 and 498.1 and 506.1 and 514.1 or 513.1 and 509.1 and 514.2 and 506.1 and 498.3 or 498.2 and 509.1 and 513.2 and 514.2 and 506.1 or 509.1 and 513.2 and 498.1 and 514.2 and 506.1) and (10632.1 and 4905.1 and 10476.1 and 9551.3 and 522.5 and 516.2 and 521.1 and 515.1 or 518.3 and 4905.1 and 515.2 and 10476.2 and 521.1 and 10632.1 and 9551.3 and 522.3 or 4905.1 and 515.2 and 10476.2 and 521.1 and 10632.1 and 517.2 and 9551.2 and 522.3 or 10632.1 and 4905.1 and 10476.1 and 522.5 and 9551.2 and 518.2 and 521.1 and 515.1 or 4905.1 and 515.2 and 10476.2 and 516.2 and 521.1 and 10632.1 and 9551.3 and 522.5 or 518.3 and 4905.1 and 9551.1 and 515.2 and 10476.2 and 521.1 and 10632.1 and 522.4 or 10632.1 and 4905.1 and 10476.1 and 9551.1 and 522.2 and 515.2 and 518.2 and 521.1 or 518.3 and 10632.1 and 4905.1 and 10476.1 and 515.3 and 9551.2 and 522.4 and 521.1 or 10632.1 and 4905.1 and 10476.1 and 515.3 and 522.2 and 9551.3 and 518.2 and 521.1 or 4905.1 and 9551.1 and 10476.2 and 522…
reactant: MODEL1310110063#
fast: false
is: SBO:0000185
is version of: http://identifiers.org/ec-code/3.6.1.14
reversible: false

metaR r0797
kinetic law: MODEL1310110063#
name: glycine N-choloyltransferase EC:2.3.1.65
is described by: ECO:0000000
reversible: true
notes: GENE_ASSOCIATION: (220.1) or (218.1) or (221.1) or (222.1) or (U37519.1) SUBSYSTEM: Bile acid synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:12810727,PMID:6884990 NOTES:
fast: false
modifier: MODEL1310110063#
type: Reaction
product: MODEL1310110063#
reactant: MODEL1310110063#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.2.1.5

http://identifiers.org/biomodels.db/MODEL1310110063#_d2b3f418_d1b7_4f8c_b52b_b58daec80a98
is: SBO:0000252
type: Species
boundary condition: true
constant: false
name: GALNT10
initial amount: NaN
has only substance units: false
is encoded by: hsa:55568
initial concentration: NaN

metaR r0917
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
reactant: MODEL1310110063#
reversible: true
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172 NOTES:
is described by: ECO:0000000
type: Reaction
fast: false
kinetic law: MODEL1310110063#
product: MODEL1310110063#

metaR LTD4DP
reactant: MODEL1310110063#
reversible: true
fast: false
product: MODEL1310110063#
type: Reaction
is: SBO:0000176
kinetic law: MODEL1310110063#
name: Leukotriene D4 dipeptidase
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Eicosanoid metabolism EC Number: 2.3.2.2 Confidence Level: 4 AUTHORS: PMID:11160764,PMID:3001504 NOTES:Converts leukotriene D4 (LTD4) to leukotriene E4 (LTE4). unknown compartmentalization, cytosolic by default NJ

metaR RE2626C
type: Reaction
reactant: MODEL1310110063#
product: MODEL1310110063#
notes: GENE_ASSOCIATION: SUBSYSTEM: Bile acid synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:9210654,PMID:9660774 NOTES:
is: SBO:0000176
kinetic law: MODEL1310110063#
fast: false
name: RE2626
reversible: true
is described by: ECO:0000000

metaM hs deg1 l
is: CHEBI:17180
has only substance units: false
is: SBO:0000247
boundary condition: false
type: Species
notes: FORMULA: C79H115N5O99S11 CHARGE: -12
initial concentration: 1.0
constant: false
name: heparan sulfate, degradation product 1
is: HMDB01352
initial amount: NaN

metaR UDPACGALtl
fast: false
name: udpacgal intracellular transport
product: MODEL1310110063#
is described by: ECO:0000000
reactant: MODEL1310110063#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 1 AUTHORS: NOTES:unknown mechanism for transport - there are UDPACGAL-translocators for ER and Golgi, however no info on lysosomal - poor support for this NJ
reversible: true
kinetic law: MODEL1310110063#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110063#_0a43a04f_e15b_4234_8a09_26dbf184d786
constant: false
type: Species
name: NME1
is encoded by: hsa:4830
initial concentration: NaN
boundary condition: true
initial amount: NaN
has only substance units: false
is: SBO:0000252

metaR r2509
is: SBO:0000185
type: Reaction
name: Utilized transport
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:17466261 NOTES:
reactant: MODEL1310110063#
product: MODEL1310110063#
fast: false
kinetic law: MODEL1310110063#
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110063#_081da5b2_64c4_4784_ad4c_da706a546931
type: Species
name: GGT5
is encoded by: hsa:2687
initial amount: NaN
initial concentration: NaN
has only substance units: false
constant: false
is: SBO:0000252
is: P36269
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110063#_3de552fd_bc2c_4ee6_b792_34a8b451256b
name: ALG12
constant: false
is: Q9BV10
is encoded by: hsa:79087
is: SBO:0000252
initial concentration: NaN
type: Species
boundary condition: true
initial amount: NaN
has only substance units: false

metaR CYTK13
name: cytidylate kinase (dCMP,dATP)
is: SBO:0000176
type: Reaction
is described by: ECO:0000269
modifier: MODEL1310110063#
is version of: http://identifiers.org/ec-code/2.7.4.14
kinetic law: MODEL1310110063#
reactant: MODEL1310110063#
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
fast: false
product: MODEL1310110063#
reversible: true

metaM mi145p c
is: HMDB01498
has only substance units: false
type: Species
initial amount: NaN
boundary condition: false
name: 1D-myo-inositol 1,4,5-trisphosphate(6-)
notes: FORMULA: C6H9O15P3 CHARGE: -6 INCHI: InChI=1S/C6H15O15P3/c7-1-2(8)5(20-23(13,14)15)6(21-24(16,17)18)3(9)4(1)19-22(10,11)12/h1-9H,(H2,10,11,12)(H2,13,14,15)(H2,16,17,18)/p-6/t1-,2+,3+,4-,5-,6-/m1/s1 EHMN_ABBREVIATION: C01245
initial concentration: 1.0
is: CHEBI:203600
constant: false
is: SBO:0000247

metaR r1428
reactant: MODEL1310110063#
product: MODEL1310110063#
name: Free diffusion
reversible: true
is: SBO:0000185
fast: false
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 0 AUTHORS: PMID:17045662 NOTES:
kinetic law: MODEL1310110063#
type: Reaction

metaM prist x
boundary condition: false
is: CHEBI:51340
is: SBO:0000247
initial amount: NaN
has only substance units: false
is: HMDB00795
notes: FORMULA: C19H37O2 CHARGE: -1 INCHI: InChI=1S/C19H38O2/c1-15(2)9-6-10-16(3)11-7-12-17(4)13-8-14-18(5)19(20)21/h15-18H,6-14H2,1-5H3,(H,20,21)
name: pristanic acid
type: Species
initial concentration: 1.0
constant: false

metaM pail5p hs n
is: CHEBI:57795
name: 1-phosphatidyl-1D-myo-inositol 5-phosphate(3-)
constant: false
notes: FORMULA: C9H15O12P2FULLRCO2FULLR2CO2 CHARGE: -3
has only substance units: false
initial amount: NaN
type: Species
initial concentration: 1.0
boundary condition: false
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110063#_35ed3d52_a616_4c28_bf5d_30f3955c1f1e
name: PLCXD2
initial concentration: NaN
is encoded by: hsa:257068
boundary condition: true
has only substance units: false
constant: false
type: Species
is: SBO:0000252
is: Q0VAA5
initial amount: NaN

metaR RE2658R
kinetic law: MODEL1310110063#
is described by: ECO:0000000
product: MODEL1310110063#
is: SBO:0000176
reversible: true
type: Reaction
reactant: MODEL1310110063#
notes: GENE_ASSOCIATION: SUBSYSTEM: Vitamin A metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:9647871 NOTES:
fast: false
name: RE2658

metaR FAOXC181C181OHm
kinetic law: MODEL1310110063#
product: MODEL1310110063#
reactant: MODEL1310110063#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C18:1-->C18:1OH)m
type: Reaction

metaM ksi pre17 g
has only substance units: false
name: keratan sulfate I biosynthesis, precursor 17
constant: false
is: SBO:0000247
type: Species
notes: FORMULA: C157H252N11O127S5X CHARGE: -6
boundary condition: false
initial amount: NaN
initial concentration: 1.0
is: CHEBI:28067

metaM ksi l
is: HMDB01354
constant: false
is: C00445
is: CHEBI:57455
notes: FORMULA: C247H393N17O213S12X CHARGE: -13
name: keratan sulfate I
is: SBO:0000247
initial amount: NaN
has only substance units: false
boundary condition: false
initial concentration: 1.0
type: Species

http://identifiers.org/biomodels.db/MODEL1310110063#_49665257_eacb_43a9_bf9d_2f6e0af28dd1
name: TKTL2
constant: false
has only substance units: false
initial amount: NaN
type: Species
is: Q9H0I9
initial concentration: NaN
is: SBO:0000252
boundary condition: true
is encoded by: hsa:84076

http://identifiers.org/biomodels.db/MODEL1310110063#_8089d83a_ef89_4e38_814d_c26cc883941f
type: Species
name: ADH1A
is: SBO:0000252
is: P07327
boundary condition: true
initial amount: NaN
is encoded by: hsa:124
has only substance units: false
constant: false
initial concentration: NaN

metaR NRPPHRt4 2 r
modifier: MODEL1310110063#
product: MODEL1310110063#
type: Reaction
is: SBO:0000185
name: Norepinephrine reversible transport in via sodium symport (1:2)
is described by: ECO:0000269
reversible: true
kinetic law: MODEL1310110063#
fast: false
notes: GENE_ASSOCIATION: (6530.1) or (6531.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12719981 NOTES:SAB
reactant: MODEL1310110063#

metaM dopasf c
name: dopamine 3-O-sulfate
boundary condition: false
initial amount: NaN
is: HMDB06275
has only substance units: false
type: Species
notes: FORMULA: C8H11NO5S CHARGE: 0 INCHI: InChI=1S/C8H11NO5S/c9-4-3-6-1-2-7(10)8(5-6)14-15(11,12)13/h1-2,5,10H,3-4,9H2,(H,11,12,13) EHMN_ABBREVIATION: C13690
is: SBO:0000247
constant: false
initial concentration: 1.0
is: CHEBI:37946

http://identifiers.org/biomodels.db/MODEL1310110063#_b91aa378_7c5e_4e11_b772_1fe5de72916b
has only substance units: false
name: NDUFS3
initial amount: NaN
is: SBO:0000252
type: Species
is encoded by: hsa:4722
is: O75489
constant: false
initial concentration: NaN
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110063#_1bc5e617_6d9d_41a3_ba8d_84230ccb1628
constant: false
name: _AL038231_1_c
boundary condition: true
initial concentration: NaN
is: SBO:0000252
type: Species
has only substance units: false
initial amount: NaN
is encoded by: hsa:AL038231

metaR EX malttr LPAREN e RPAREN
kinetic law: MODEL1310110063#
reactant: MODEL1310110063#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Maltotriose exchange
type: Reaction

metaM nadp x
type: Species
notes: FORMULA: C21H25N7O17P3 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00016 EHMN_ABBREVIATION: C00006
is: CHEBI:58349
initial amount: NaN
is: HMDB00217
is: C00006
constant: false
boundary condition: false
has only substance units: false
initial concentration: 1.0
name: Nicotinamide adenine dinucleotide phosphate
is: SBO:0000247

metaR r2508
reversible: true
product: MODEL1310110063#
type: Reaction
is described by: ECO:0000000
name: Utilized transport
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:17466261 NOTES:
fast: false
reactant: MODEL1310110063#
kinetic law: MODEL1310110063#

metaR BAAT4x
fast: false
reactant: MODEL1310110063#
is: SBO:0000176
notes: GENE_ASSOCIATION: (570.1) SUBSYSTEM: Bile acid synthesis EC Number: 2.3.1.65 Confidence Level: 2 AUTHORS: NOTES:fourth version analog added in similarity to BAAT1x, BAAT2x NJ
kinetic law: MODEL1310110063#
is version of: http://identifiers.org/ec-code/2.3.1.65
reversible: false
name: bile acid Coenzyme A: amino acid N-acyltransferase
modifier: MODEL1310110063#
product: MODEL1310110063#
is described by: ECO:0000304
type: Reaction

metaR CAROtr
is described by: ECO:0000000
type: Reaction
is: SBO:0000185
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:1503811 NOTES:IT
kinetic law: MODEL1310110063#
product: MODEL1310110063#
name: beta-carotene transport via diffusion
fast: false
reactant: MODEL1310110063#

metaM ksi pre16 g
initial concentration: 1.0
is: C00130
is: SBO:0000247
initial amount: NaN
name: keratan sulfate I biosynthesis, precursor 16
is: HMDB00175
has only substance units: false
notes: FORMULA: C157H253N11O124S4X CHARGE: -5
constant: false
is: CHEBI:58053
boundary condition: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110063#_ed8c9994_1164_40be_8480_1ff4f3f4fabc
constant: false
is: SBO:0000252
name: SLC6A3
has only substance units: false
is: Q01959
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:6531
boundary condition: true
type: Species

metaR ACOAD9m
is: SBO:0000176
fast: false
is version of: http://identifiers.org/ec-code/1.3.99.3
name: acyl-CoA dehydrogenase (isobutyryl-CoA), mitochondrial
notes: GENE_ASSOCIATION: (34.1) or (27034.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 1.3.99.12 Confidence Level: 4 AUTHORS: PMID:11013134 NOTES:MM
kinetic law: MODEL1310110063#
type: Reaction
modifier: MODEL1310110063#
reactant: MODEL1310110063#
reversible: false
product: MODEL1310110063#
is described by: ECO:0000269

http://identifiers.org/biomodels.db/MODEL1310110063#_4b5aa663_9c29_40fc_bbc4_84068c5a8c6f
is: P15121
name: AKR1B1
type: Species
boundary condition: true
is: SBO:0000252
constant: false
initial amount: NaN
is encoded by: hsa:231
has only substance units: false
initial concentration: NaN

metaR GLXtm
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 1 AUTHORS: PMID:15240345 NOTES:NCD
name: glyoxylate transport, mitochondrial
fast: false
reactant: MODEL1310110063#
product: MODEL1310110063#
kinetic law: MODEL1310110063#
type: Reaction
is: SBO:0000185
is described by: ECO:0000000
reversible: true

metaR S23T3g
reactant: MODEL1310110063#
fast: false
modifier: MODEL1310110063#
notes: GENE_ASSOCIATION: (6487.4) or (6487.9) or (6487.11) or (6487.6) or (6487.7) or (6487.10) or (6487.5) or (6487.1) or (6487.2) or (6487.8) or (6487.3) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.99.6 Confidence Level: 4 AUTHORS: PMID:8333853 NOTES:NCD
is described by: ECO:0000000
is: SBO:0000176
kinetic law: MODEL1310110063#
product: MODEL1310110063#
is version of: http://identifiers.org/ec-code/2.4.99.6
type: Reaction
reversible: false
name: beta-galactoside alpha-2,3-sialyltransferase (complex N-glycan)

metaM 3oddcoa x
boundary condition: false
constant: false
has only substance units: false
is: CHEBI:27868
is: SBO:0000247
name: 3-Oxododecanoyl-CoA
type: Species
is: HMDB03937
initial amount: NaN
notes: FORMULA: C33H52N7O18P3S CHARGE: -4 INCHI: InChI=1S/C33H56N7O18P3S/c1-4-5-6-7-8-9-10-11-21(41)16-24(43)62-15-14-35-23(42)12-13-36-31(46)28(45)33(2,3)18-55-61(52,53)58-60(50,51)54-17-22-27(57-59(47,48)49)26(44)32(56-22)40-20-39-25-29(34)37-19-38-30(25)40/h19-20,22,26-28,32,44-45H,4-18H2,1-3H3,(H,35,42)(H,36,46)(H,50,51)(H,52,53)(H2,34,37,38)(H2,47,48,49)/t22-,26-,27-,28+,32-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01402 EHMN_ABBREVIATION: C05263
initial concentration: 1.0

metaR PRAGSr
modifier: MODEL1310110063#
notes: GENE_ASSOCIATION: (2618.1) or (2618.2) SUBSYSTEM: Purine synthesis EC Number: Confidence Level: 4 AUTHORS: NOTES:
fast: false
kinetic law: MODEL1310110063#
type: Reaction
reversible: true
is version of: http://identifiers.org/ec-code/2.1.2.2
product: MODEL1310110063#
is: SBO:0000176
reactant: MODEL1310110063#
name: phosphoribosylglycinamide synthase
is described by: ECO:0000269

http://identifiers.org/biomodels.db/MODEL1310110063#_9d2caa6e_995d_480c_8f15_7f879f01c247
name: DGKZ
initial concentration: NaN
has only substance units: false
is: G3V0F6
type: Species
is encoded by: hsa:8525
is: SBO:0000252
boundary condition: true
initial amount: NaN
constant: false

http://identifiers.org/biomodels.db/MODEL1310110063#_60c2f248_4af9_41f6_9984_568e6fb4f3a2
is encoded by: hsa:5236
is: B4DPV0
initial concentration: NaN
type: Species
boundary condition: true
has only substance units: false
name: PGM1
constant: false
is: SBO:0000252
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110063#_827dd3f2_4c40_4329_9c7a_269dc08ce160
is: SBO:0000252
initial concentration: NaN
name: HYAL3
has only substance units: false
boundary condition: true
type: Species
initial amount: NaN
is: O43820
constant: false
is encoded by: hsa:8372

http://identifiers.org/biomodels.db/MODEL1310110063#_304c6aa4_b17a_4c7b_b442_910356725eac
is: O95497
name: VNN1
type: Species
boundary condition: true
has only substance units: false
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:8876
constant: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110063#_2a793bfb_d277_4799_a653_06d74e715f90
boundary condition: true
constant: false
has only substance units: false
is encoded by: hsa:3948
type: Species
initial concentration: NaN
is: P07864
is: SBO:0000252
name: LDHC
initial amount: NaN

metaR CYTK11
modifier: MODEL1310110063#
is version of: http://identifiers.org/ec-code/2.7.4.14
is: SBO:0000176
is described by: ECO:0000269
type: Reaction
kinetic law: MODEL1310110063#
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
product: MODEL1310110063#
name: cytidylate kinase (dCMP,dGTP)
fast: false
reactant: MODEL1310110063#
reversible: true

metaM CE1943 e
type: Species
is: HMDB02329
name: spermidine dialdehyde
initial amount: NaN
initial concentration: 1.0
constant: false
notes: FORMULA: C7H14NO2 CHARGE: 1 INCHI: InChI=1/C7H13NO2/c9-6-2-1-4-8-5-3-7-10/h6-8H,1-5H2/p+1 EHMN_ABBREVIATION: CE1943
boundary condition: false
is: CHEBI:30623
is: SBO:0000247
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110063#_a3dad691_c499_498e_85c5_cb1b469dfe28
initial amount: NaN
constant: false
boundary condition: true
is encoded by: hsa:790
is: P27708
is: SBO:0000252
initial concentration: NaN
name: CAD
has only substance units: false
type: Species

metaR GLXtp
fast: false
kinetic law: MODEL1310110063#
type: Reaction
reversible: true
is described by: ECO:0000000
product: MODEL1310110063#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 1 AUTHORS: PMID:15240345 NOTES:NCD
reactant: MODEL1310110063#
name: glyoxylate transport, peroxisomal
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110063#_9abce30a_9636_42cf_a076_cb6bcd884db2
name: ST3GAL3
type: Species
is: SBO:0000252
boundary condition: true
has only substance units: false
initial amount: NaN
is encoded by: hsa:6487
constant: false
initial concentration: NaN
is: Q5T4Y1

metaM thm c
has only substance units: false
initial concentration: 1.0
constant: false
is: C00378
type: Species
notes: FORMULA: C12H17N4OS CHARGE: 1
boundary condition: false
is: HMDB00235
name: Thiamin
is: SBO:0000247
is: CHEBI:0
initial amount: NaN

metaR PACCOAL
is: SBO:0000176
is described by: ECO:0000000
kinetic law: MODEL1310110063#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Phenylalanine metabolism EC Number: 6.2.1.30 Confidence Level: 2 AUTHORS: NOTES:JLR
name: phenylacetate-CoA ligase
reversible: false
type: Reaction
product: MODEL1310110063#
reactant: MODEL1310110063#

http://identifiers.org/biomodels.db/MODEL1310110063#_8045ec4d_2553_4c9e_b65f_73a28451e0d7
has only substance units: false
initial amount: NaN
boundary condition: true
type: Species
constant: false
initial concentration: NaN
name: QDPR
is: P09417
is encoded by: hsa:5860
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110063#_65465a5d_7d10_4c87_a804_ab915c0fc41f
has only substance units: false
boundary condition: true
constant: false
is: SBO:0000252
type: Species
is: Q9H6Y6
initial amount: NaN
is encoded by: hsa:4645
name: MYO5B
initial concentration: NaN

metaR r1429
type: Reaction
fast: false
name: Free diffusion
reactant: MODEL1310110063#
reversible: true
is described by: ECO:0000000
kinetic law: MODEL1310110063#
product: MODEL1310110063#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 0 AUTHORS: PMID:17045662 NOTES:
is: SBO:0000185

metaR CYTK12
is version of: http://identifiers.org/ec-code/2.7.4.14
reversible: true
modifier: MODEL1310110063#
kinetic law: MODEL1310110063#
is: SBO:0000176
fast: false
type: Reaction
reactant: MODEL1310110063#
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
product: MODEL1310110063#
name: cytidylate kinase (dCMP,dCTP)
is described by: ECO:0000269

http://identifiers.org/biomodels.db/MODEL1310110063#_4d4ac9e5_dcc5_4f3e_8631_59295b585349
name: NDUFS8
constant: false
is encoded by: hsa:4728
boundary condition: true
is: SBO:0000252
initial concentration: NaN
type: Species
is: O00217
has only substance units: false
initial amount: NaN

metaR BTNt2
notes: GENE_ASSOCIATION: (6566.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10510291,PMID:12739169,PMID:7835905,PMID:8476015,PMID:9508842,PMID:9649795,PMID:9824713 NOTES:NCD
product: MODEL1310110063#
name: Biotin reversible transport via proton symport
is described by: ECO:0000269
type: Reaction
reversible: true
is: SBO:0000185
modifier: MODEL1310110063#
fast: false
kinetic law: MODEL1310110063#
reactant: MODEL1310110063#

metaR DM 13 cis retn n
kinetic law: MODEL1310110063#
reactant: MODEL1310110063#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 0 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: false
name: 13-cis-retinoate demand
type: Reaction

metaR EX lnlnca LPAREN e RPAREN
kinetic law: MODEL1310110063#
reactant: MODEL1310110063#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: alpha-Linolenic acid exchange
type: Reaction

metaM 3htdcoa c
is: SBO:0000247
initial amount: NaN
constant: false
boundary condition: false
type: Species
is: HMDB02014
has only substance units: false
name: (S)-3-Hydroxytetradecanoyl-CoA
notes: FORMULA: C35H58N7O18P3S CHARGE: -4
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110063#_90f7b785_37c4_4bed_95ea_6300a47185b4
initial amount: NaN
constant: false
boundary condition: true
type: Species
is: SBO:0000252
is encoded by: hsa:2542
initial concentration: NaN
is: A8K0S7
name: SLC37A4
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110063#_1174bf77_62ee_45d9_97b1_30b52949b409
is: O00400
is encoded by: hsa:9197
initial amount: NaN
type: Species
is: SBO:0000252
name: SLC33A1
boundary condition: true
has only substance units: false
initial concentration: NaN
constant: false

metaR CYTK12n
is described by: ECO:0000269
type: Reaction
reactant: MODEL1310110063#
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
name: cytidylate kinase (dCMP,dCTP),nuclear
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.7.4.14
fast: false
product: MODEL1310110063#
kinetic law: MODEL1310110063#
modifier: MODEL1310110063#
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110063#_b47a8a0e_76fb_4386_b8a0_3ac1bc38bf35
initial amount: NaN
has only substance units: false
name: COX7A2
is: SBO:0000252
initial concentration: NaN
constant: false
is encoded by: hsa:1347
is: H0UI06
boundary condition: true
type: Species

metaR MANtg
product: MODEL1310110063#
reactant: MODEL1310110063#
is: SBO:0000185
kinetic law: MODEL1310110063#
name: mannose efflux from Golgi apparatus
is described by: ECO:0000000
fast: false
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110063#_dc9e8352_08dd_4a57_905d_085c66766c1a
type: Species
name: HAS2
has only substance units: false
initial amount: NaN
initial concentration: NaN
is: Q92819
is: SBO:0000252
constant: false
is encoded by: hsa:3037
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110063#_ad525e79_5f4c_4ddc_b649_065c31fe55e6
is: SBO:0000252
name: RPE
initial concentration: NaN
is encoded by: hsa:6120
constant: false
is: Q96AT9
initial amount: NaN
has only substance units: false
boundary condition: true
type: Species

http://identifiers.org/biomodels.db/MODEL1310110063#_ef86a516_e94f_406d_9247_c49f24f437bb
is: SBO:0000252
is: Q9NVE7
has only substance units: false
initial amount: NaN
is encoded by: hsa:55229
type: Species
initial concentration: NaN
constant: false
name: PANK4
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110063#_7de2b6d1_a5f9_4a0f_81c0_4f8bb02b617a
constant: false
is: Q9HAB8
initial concentration: NaN
is encoded by: hsa:79717
is: SBO:0000252
name: PPCS
has only substance units: false
type: Species
boundary condition: true
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110063#_b8d23ea5_22f3_470d_a80d_4e49aa912796
is encoded by: hsa:127
boundary condition: true
initial concentration: NaN
type: Species
constant: false
name: ADH4
is: SBO:0000252
is: P08319
has only substance units: false
initial amount: NaN

metaR C101CRNe
kinetic law: MODEL1310110063#
product: MODEL1310110063#
reactant: MODEL1310110063#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of decenoyl carnitine into extra cellular space
type: Reaction

metaR AIRCr
is version of: http://identifiers.org/ec-code/6.3.2.6
reversible: true
product: MODEL1310110063#
reactant: MODEL1310110063#
modifier: MODEL1310110063#
kinetic law: MODEL1310110063#
is: SBO:0000176
type: Reaction
name: phosphoribosylaminoimidazole carboxylase
fast: false
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (10606.1) SUBSYSTEM: Purine synthesis EC Number: Confidence Level: 4 AUTHORS: NOTES:

metaM doco13ac e
is: SBO:0000247
boundary condition: false
has only substance units: false
initial amount: NaN
initial concentration: 1.0
notes: FORMULA: C22H41O2 CHARGE: -1
constant: false
name: docosenoic acid (C22:1)
is: HMDB02068
type: Species

http://identifiers.org/biomodels.db/MODEL1310110063#_0030faeb_e4ed_45a9_87eb_641a7f64cbb7
initial concentration: NaN
is: SBO:0000252
type: Species
boundary condition: true
initial amount: NaN
has only substance units: false
constant: false
name: DPM2
is encoded by: hsa:8818
is: O94777

metaM c3dc c
name: malonyl carnitine
initial amount: NaN
is: HMDB02095
constant: false
initial concentration: 1.0
is: SBO:0000247
has only substance units: false
type: Species
boundary condition: false
notes: FORMULA: C10H16NO6 CHARGE: -1

http://identifiers.org/biomodels.db/MODEL1310110063#_2e11c22e_a65a_49c7_a746_9eaa126a5808
is encoded by: hsa:2109
constant: false
has only substance units: false
initial concentration: NaN
boundary condition: true
is: SBO:0000252
name: ETFB
type: Species
initial amount: NaN

metaR AMETt2m
reversible: true
product: MODEL1310110063#
type: Reaction
name: S-Adenosyl-L-methionine reversible transport, mitochondrial
is described by: ECO:0000269
kinetic law: MODEL1310110063#
modifier: MODEL1310110063#
is: SBO:0000185
notes: GENE_ASSOCIATION: (115286.3) or (115286.2) or (115286.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14674884 NOTES:Added by RS/TV (6/17/05)
reactant: MODEL1310110063#
fast: false

metaR EX ocdcea LPAREN e RPAREN
kinetic law: MODEL1310110063#
reactant: MODEL1310110063#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: octadecenoate (n-C18:1) exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110063#_537586d4_dbb1_4bfa_a030_9a4d0a5dee9b
name: HSD17B4
initial concentration: NaN
is: SBO:0000252
has only substance units: false
constant: false
type: Species
is: E9PB82
is encoded by: hsa:3295
boundary condition: true
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110063#_9fe38428_9557_43fb_a3a5_6e7e97ec0bb9
type: Species
name: LDHAL6B
is: SBO:0000252
initial concentration: NaN
has only substance units: false
constant: false
boundary condition: true
initial amount: NaN
is: Q9BYZ2
is encoded by: hsa:92483

http://identifiers.org/biomodels.db/MODEL1310110063#_c8ea579d_b77f_4a9b_b4ef_4a5f6d2f76b6
type: Species
has only substance units: false
initial concentration: NaN
name: FADS1
boundary condition: true
initial amount: NaN
constant: false
is: SBO:0000252
is encoded by: hsa:3992
is: O60427

metaR CYTK10
name: cytidylate kinase (CMP,dGTP)
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/2.7.4.14
reversible: true
product: MODEL1310110063#
is: SBO:0000176
type: Reaction
modifier: MODEL1310110063#
kinetic law: MODEL1310110063#
reactant: MODEL1310110063#
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
fast: false

metaM dolp U c
constant: false
type: Species
has only substance units: false
is: CHEBI:57683
is: SBO:0000247
initial concentration: 1.0
initial amount: NaN
boundary condition: false
notes: FORMULA: C1025H1670O40P10 CHARGE: -20 INCHI: InChI=1S/C25H45O4P/c1-21(2)11-7-12-22(3)13-8-14-23(4)15-9-16-24(5)17-10-18-25(6)19-20-29-30(26,27)28/h11,13,15,17,25H,7-10,12,14,16,18-20H2,1-6H3,(H2,26,27,28)/p-2/b22-13+,23-15+,24-17- EHMN_ABBREVIATION: C00110
name: dolichyl phosphate(2-)

metaM CE4876 r
notes: FORMULA: C20H29O4 CHARGE: -1 INCHI: InChI=1/C20H30O4/c1-2-3-6-10-17(21)13-14-18-16(12-15-19(18)22)9-7-4-5-8-11-20(23)24/h4,7,12,14-17,21H,2-3,5-6,8-11,13H2,1H3,(H,23,24)/p-1/b7-4-,18-14+/t16-,17-/m0/s1 EHMN_ABBREVIATION: CE4876
has only substance units: false
boundary condition: false
is: SBO:0000247
type: Species
is: CHEBI:57923
name: delta12-Prostaglandin J2
initial concentration: 1.0
constant: false
initial amount: NaN

metaR EX prgstrn LPAREN e RPAREN
kinetic law: MODEL1310110063#
reactant: MODEL1310110063#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Progesterone exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110063#_6b7d95dd_007e_494c_8828_c97a52e52529
is: SBO:0000252
constant: false
is encoded by: hsa:2686
initial amount: NaN
initial concentration: NaN
has only substance units: false
name: GGT7
is: A0PJJ9
type: Species
boundary condition: true

metaM docohexcoa m
boundary condition: false
notes: FORMULA: C43H62N7O17P3S CHARGE: -4
constant: false
initial amount: NaN
is: http://identifiers.org/pubchem.compound/24892790
is: SBO:0000247
has only substance units: false
type: Species
name: 2,4,7,10,13,16-docosahexenoylcoa
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110063#_96546d06_04a8_443d_92e4_5fdc325d52db
boundary condition: true
name: RPIA
is: P49247
is encoded by: hsa:22934
is: SBO:0000252
type: Species
has only substance units: false
initial amount: NaN
initial concentration: NaN
constant: false

metaR EX 4hphac LPAREN e RPAREN
kinetic law: MODEL1310110063#
reactant: MODEL1310110063#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 4-Hydroxyphenylacetate exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110063#_1773de7c_5e34_46e1_8ce1_f6fc0b31b87f
name: SLC1A5
boundary condition: true
type: Species
has only substance units: false
constant: false
is: Q15758
initial concentration: NaN
is encoded by: hsa:6510
is: SBO:0000252
initial amount: NaN

metaM glyc3p c
initial amount: NaN
constant: false
is: SBO:0000247
notes: FORMULA: C3H7O6P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00095 EHMN_ABBREVIATION: C00093
initial concentration: 1.0
is: C00093
is: HMDB00126
is: CHEBI:57597
name: Glycerol 3-phosphate
type: Species
has only substance units: false
boundary condition: false

metaM HC01115 c
initial amount: NaN
name: NeuNGc
is: SBO:0000247
initial concentration: 1.0
has only substance units: false
boundary condition: false
notes: FORMULA: C11H18NO10 CHARGE: -1 INCHI: InChI=1S/C11H19NO10/c13-2-5(16)8(18)9-7(12-6(17)3-14)4(15)1-11(21,22-9)10(19)20/h4-5,7-9,13-16,18,21H,1-3H2,(H,12,17)(H,19,20)/p-1/t4-,5+,7+,8+,9+,11?/m0/s1 EHMN_ABBREVIATION: C03410
constant: false
type: Species
is: CHEBI:29025

http://identifiers.org/biomodels.db/MODEL1310110063#_66ef270f_5f90_4834_afbf_69b877aef4a9
is: Q9NTN3
name: SLC35D1
boundary condition: true
is: SBO:0000252
type: Species
constant: false
is encoded by: hsa:23169
initial amount: NaN
has only substance units: false
initial concentration: NaN

metaR r2507
name: Utilized transport
type: Reaction
is described by: ECO:0000000
is: SBO:0000185
reversible: true
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:17466261 NOTES:
reactant: MODEL1310110063#
product: MODEL1310110063#
kinetic law: MODEL1310110063#

http://identifiers.org/biomodels.db/MODEL1310110063#_31a8bbf5_559f_431a_a073_d39c3c914543
is: O76074
is encoded by: hsa:8654
has only substance units: false
type: Species
boundary condition: true
name: PDE5A
initial concentration: NaN
constant: false
is: SBO:0000252
initial amount: NaN

metaM 2oxoadp m
is: CHEBI:57499
initial amount: NaN
is: HMDB00225
initial concentration: 1.0
boundary condition: false
type: Species
is: SBO:0000247
name: 2-oxoadipate(2-)
notes: FORMULA: C6H6O5 CHARGE: -2 INCHI: InChI=1S/C6H8O5/c7-4(6(10)11)2-1-3-5(8)9/h1-3H2,(H,8,9)(H,10,11)/p-2 HEPATONET_1.0_ABBREVIATION: HC00273 EHMN_ABBREVIATION: C00322
constant: false
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110063#_20420f0d_33ee_4571_9e06_4a6ef153e98a
has only substance units: false
initial concentration: NaN
is encoded by: hsa:11001
is: SBO:0000252
initial amount: NaN
type: Species
is: O14975
name: SLC27A2
constant: false
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110063#_d85af8e5_f9aa_404e_8ea4_2cc4de6a8981
initial concentration: NaN
has only substance units: false
boundary condition: true
constant: false
is: SBO:0000297
has part: P56134
initial amount: NaN
is encoded by: hsa:522
is encoded by: hsa:9551
name: ATP5H:ATP5L:NSF:ATP5F1:ATP5G3:ATP5I:ATP5J:ATP5J2
type: Species

http://identifiers.org/biomodels.db/MODEL1310110063#_7a284116_3336_4b8b_a15b_8084126f8aef
is: Q06830
has only substance units: false
initial amount: NaN
is encoded by: hsa:5052
constant: false
initial concentration: NaN
name: PRDX1
type: Species
is: SBO:0000252
boundary condition: true

metaM fuc1p L c
has only substance units: false
notes: FORMULA: C6H11O8P CHARGE: -2 INCHI: InChI=1S/C6H13O8P/c1-2-3(7)4(8)5(9)6(13-2)14-15(10,11)12/h2-9H,1H3,(H2,10,11,12)/t2-,3+,4+,5-,6?/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01030
is: HMDB01265
name: L-Fucose 1-phosphate
type: Species
boundary condition: false
is: CHEBI:28319
initial concentration: 1.0
constant: false
is: SBO:0000247
initial amount: NaN

metaR DHCRD2
reactant: MODEL1310110063#
is: SBO:0000176
reversible: false
kinetic law: MODEL1310110063#
notes: GENE_ASSOCIATION: (8560.1) or (8560.2) SUBSYSTEM: Sphingolipid metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:9188692 NOTES:NJ
fast: false
name: dihydroceramide desaturase
is described by: ECO:0000269
product: MODEL1310110063#
type: Reaction
modifier: MODEL1310110063#

metaR PYK
is described by: ECO:0000134
notes: GENE_ASSOCIATION: (5315.2) or (5313.2) or (5315.3) or (5313.1) or (113452.1) or (5315.1) SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: Confidence Level: 0 AUTHORS: NOTES:
modifier: MODEL1310110063#
type: Reaction
reversible: false
kinetic law: MODEL1310110063#
is: SBO:0000176
name: pyruvate kinase
reactant: MODEL1310110063#
is version of: http://identifiers.org/ec-code/2.7.1.40
fast: false
product: MODEL1310110063#

http://identifiers.org/biomodels.db/MODEL1310110063#_7b3704c5_aeae_40d7_b0d4_44821806b2d3
is: Q9P0J0
is encoded by: hsa:51079
initial concentration: NaN
is: SBO:0000252
type: Species
boundary condition: true
constant: false
has only substance units: false
initial amount: NaN
name: NDUFA13

metaM HC00342 c
is: CHEBI:16383
initial amount: NaN
boundary condition: false
constant: false
initial concentration: 1.0
type: Species
name: cis-aconitate(3-)
is: SBO:0000247
notes: FORMULA: C6H3O6 CHARGE: -3 INCHI: InChI=1S/C6H6O6/c7-4(8)1-3(6(11)12)2-5(9)10/h1H,2H2,(H,7,8)(H,9,10)(H,11,12)/p-3/b3-1- EHMN_ABBREVIATION: C00417
has only substance units: false

metaR EX tmndnc LPAREN e RPAREN
kinetic law: MODEL1310110063#
reactant: MODEL1310110063#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: timnodonic acid exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110063#_14398267_0be9_4c8f_9754_7afc59029ade
name: ALG8
constant: false
boundary condition: true
is: SBO:0000252
initial concentration: NaN
is encoded by: hsa:79053
initial amount: NaN
has only substance units: false
is: Q9BVK2
type: Species

metaR r2506
type: Reaction
name: Utilized transport
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:17466261 NOTES:
is: SBO:0000185
fast: false
reactant: MODEL1310110063#
product: MODEL1310110063#
reversible: true
kinetic law: MODEL1310110063#

metaR FAOXC123C102x
kinetic law: MODEL1310110063#
product: MODEL1310110063#
reactant: MODEL1310110063#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C12:3-->C10:2)x
type: Reaction

metaR r2433
product: MODEL1310110063#
reversible: false
fast: false
type: Reaction
is described by: ECO:0000000
reactant: MODEL1310110063#
is: SBO:0000185
name: Mitochondrial Carrier (MC) TCDB:2.A.29.8.3
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:1735445,PMID:18406340,PMID:1988962,PMID:2351134,PMID:2355017,PMID:6361812,PMID:7892212,PMID:8132483 NOTES:
kinetic law: MODEL1310110063#

http://identifiers.org/biomodels.db/MODEL1310110063#_e1c52441_3934_4f5a_a9f6_8ad326348a72
is: SBO:0000252
is: Q9H6R3
constant: false
type: Species
boundary condition: true
name: ACSS3
is encoded by: hsa:79611
initial concentration: NaN
initial amount: NaN
has only substance units: false

metaR EX 34dhphe LPAREN e RPAREN
kinetic law: MODEL1310110063#
reactant: MODEL1310110063#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 3,4-Dihydroxy-L-phenylalanine exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110063#_9b77c995_ab4b_4b60_a083_b41eae1fc7f7
initial concentration: NaN
type: Species
is: P15291
constant: false
initial amount: NaN
name: B4GALT1
has only substance units: false
boundary condition: true
is encoded by: hsa:2683
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110063#_ee09c286_51ce_4208_a8cb_4d69be7dce5b
is: SBO:0000252
constant: false
is encoded by: hsa:54539
initial concentration: NaN
name: NDUFB11
has only substance units: false
boundary condition: true
type: Species
is: Q9NX14
initial amount: NaN

metaM dgdp c
is: CHEBI:58595
notes: FORMULA: C10H12N5O10P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00305 EHMN_ABBREVIATION: C00361
constant: false
name: dGDP
initial amount: NaN
is: HMDB00960
type: Species
boundary condition: false
has only substance units: false
is: C00361
initial concentration: 1.0
is: SBO:0000247

metaM HC01407 m
boundary condition: false
name: (S)-Hydroxyhexanoyl-CoA
initial amount: NaN
initial concentration: 1.0
is: SBO:0000247
has only substance units: false
constant: false
type: Species
notes: FORMULA: C27H42N7O18P3S CHARGE: -4 INCHI: InChI=1S/C27H46N7O18P3S/c1-4-5-15(35)10-18(37)56-9-8-29-17(36)6-7-30-25(40)22(39)27(2,3)12-49-55(46,47)52-54(44,45)48-11-16-21(51-53(41,42)43)20(38)26(50-16)34-14-33-19-23(28)31-13-32-24(19)34/h13-16,20-22,26,35,38-39H,4-12H2,1-3H3,(H,29,36)(H,30,40)(H,44,45)(H,46,47)(H2,28,31,32)(H2,41,42,43)/t15-,16+,20+,21+,22-,26+/m0/s1 EHMN_ABBREVIATION: C05268
is: CHEBI:28276

metaR PMANM
kinetic law: MODEL1310110063#
is version of: http://identifiers.org/ec-code/5.4.2.8
type: Reaction
reversible: true
product: MODEL1310110063#
reactant: MODEL1310110063#
modifier: MODEL1310110063#
fast: false
is: SBO:0000176
is described by: ECO:0000000
name: phosphomannomutase
notes: GENE_ASSOCIATION: (5372.1) or (55276.1) or (5373.1) SUBSYSTEM: Fructose and mannose metabolism EC Number: 5.4.2.8 Confidence Level: 0 AUTHORS: NOTES:
is version of: http://identifiers.org/ec-code/5.4.2.2

metaR FAOXC121x
kinetic law: MODEL1310110063#
product: MODEL1310110063#
reactant: MODEL1310110063#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: isomerization(C12:1)x
type: Reaction

metaR G14T10g
is version of: http://identifiers.org/ec-code/2.4.1.38
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/2.4.1.22
is version of: http://identifiers.org/ec-code/2.4.1.90
product: MODEL1310110063#
reactant: MODEL1310110063#
is: SBO:0000176
notes: GENE_ASSOCIATION: (9334.1) or (2683.1) or (8703.1) or (8704.2) or (8704.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.38 Confidence Level: 4 AUTHORS: PMID:12512857,PMID:1903938,PMID:3094506,PMID:3144273,PMID:9405390,PMID:9435216 NOTES:Keratan sulfate I biosynthesis NCD
fast: false
name: beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase, Golgi
modifier: MODEL1310110063#
type: Reaction
reversible: false
kinetic law: MODEL1310110063#

metaR S6TASE9ly
product: MODEL1310110063#
reactant: MODEL1310110063#
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) SUBSYSTEM: Chondroitin sulfate degradation EC Number: 3.1.6.4 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD
modifier: MODEL1310110063#
reversible: true
fast: false
is version of: http://identifiers.org/ec-code/3.4.16.5
is version of: http://identifiers.org/ec-code/3.2.1.23
is version of: http://identifiers.org/ec-code/3.1.6.4
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/3.2.1.18
type: Reaction
name: N-acetylgalactosamine-6-sulfatase, lysosomal
kinetic law: MODEL1310110063#
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110063#_778b3003_352f_4c47_863c_2fb41e365d7c
is encoded by: hsa:2348
boundary condition: true
is: SBO:0000252
constant: false
type: Species
initial amount: NaN
initial concentration: NaN
has only substance units: false
name: FOLR1

metaR r0480
name: S-Adenosyl-L-methionine:ethanolamine-phosphate N-methyltransferase Glycerophospholipid metabolism EC:2.1.1.103
type: Reaction
product: MODEL1310110063#
reactant: MODEL1310110063#
kinetic law: MODEL1310110063#
notes: GENE_ASSOCIATION: SUBSYSTEM: Glycerophospholipid metabolism EC Number: 2.1.1.103 Confidence Level: 0 AUTHORS: PMID:2403362 NOTES:
fast: false
is: SBO:0000176
is described by: ECO:0000000
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110063#_02150d66_f402_442f_9d56_c0289b06fe60
initial amount: NaN
type: Species
is: P17735
name: TAT
is: SBO:0000252
constant: false
is encoded by: hsa:6898
initial concentration: NaN
has only substance units: false
boundary condition: true

metaR G14T12g
reversible: false
is version of: http://identifiers.org/ec-code/2.4.1.38
type: Reaction
fast: false
is described by: ECO:0000000
product: MODEL1310110063#
is version of: http://identifiers.org/ec-code/2.4.1.22
reactant: MODEL1310110063#
name: beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase, Golgi
notes: GENE_ASSOCIATION: (8703.1) or (2683.1) or (8704.2) or (8704.1) or (9334.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.38 Confidence Level: 4 AUTHORS: PMID:12512857,PMID:1903938,PMID:3094506,PMID:3144273,PMID:9405390,PMID:9435216 NOTES:Keratan sulfate I biosynthesis NCD
is version of: http://identifiers.org/ec-code/2.4.1.90
modifier: MODEL1310110063#
is: SBO:0000176
kinetic law: MODEL1310110063#

metaM crn r
type: Species
initial amount: NaN
is: HMDB00062
is: SBO:0000247
constant: false
has only substance units: false
notes: FORMULA: C7H15NO3 CHARGE: 0 INCHI: InChI=1S/C7H15NO3/c1-8(2,3)5-6(9)4-7(10)11/h6,9H,4-5H2,1-3H3/t6-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00270 EHMN_ABBREVIATION: C00318
boundary condition: false
is: CHEBI:16347
name: (R)-carnitine
initial concentration: 1.0

metaM tchola x
constant: false
is: SBO:0000247
initial amount: NaN
notes: FORMULA: C26H45NO7S CHARGE: 0 INCHI: InChI=1S/C26H45NO7S/c1-15(4-7-23(31)27-10-11-35(32,33)34)18-5-6-19-24-20(14-22(30)26(18,19)3)25(2)9-8-17(28)12-16(25)13-21(24)29/h15-22,24,28-30H,4-14H2,1-3H3,(H,27,31)(H,32,33,34)/p-1/t15-,16+,17-,18-,19+,20+,21-,22+,24+,25+,26-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01378 EHMN_ABBREVIATION: C05122
type: Species
is: CHEBI:36257
has only substance units: false
boundary condition: false
initial concentration: 1.0
name: taurocholate
is: HMDB00036

metaM chsterol c
type: Species
has only substance units: false
is: CHEBI:16113
is: HMDB00067
initial amount: NaN
name: cholesterol
boundary condition: false
notes: FORMULA: C27H46O CHARGE: 0 INCHI: InChI=1S/C27H46O/c1-18(2)7-6-8-19(3)23-11-12-24-22-10-9-20-17-21(28)13-15-26(20,4)25(22)14-16-27(23,24)5/h9,18-19,21-25,28H,6-8,10-17H2,1-5H3/t19-,21+,22+,23-,24+,25+,26+,27-/m1/s1
initial concentration: 1.0
constant: false
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110063#_07b2bfaf_aece_47e5_96ab_8edfb2f2022e
boundary condition: true
constant: false
name: PLA2G2A
is: P14555
is encoded by: hsa:5320
initial amount: NaN
initial concentration: NaN
type: Species
has only substance units: false
is: SBO:0000252

metaM HC02179 e
initial concentration: 1.0
is: CHEBI:34306
constant: false
has only substance units: false
initial amount: NaN
is: SBO:0000247
name: 20-hydroxy-arachidonate
type: Species
notes: FORMULA: C20H31O3 CHARGE: -1 INCHI: InChI=1S/C20H32O3/c21-19-17-15-13-11-9-7-5-3-1-2-4-6-8-10-12-14-16-18-20(22)23/h1,3-4,6-7,9-10,12,21H,2,5,8,11,13-19H2,(H,22,23)/b3-1-,6-4-,9-7-,12-10- EHMN_ABBREVIATION: C14748
boundary condition: false

metaR r1433
is: SBO:0000176
type: Reaction
kinetic law: MODEL1310110063#
fast: false
product: MODEL1310110063#
reactant: MODEL1310110063#
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 1.8.1.9 Confidence Level: 0 AUTHORS: PMID:5553404,PMID:5671058 NOTES:
name: NADPH:oxidized-thioredoxin oxidoreductase Pyrimidine metabolism EC:1.8.1.9
is described by: ECO:0000000
reversible: false

metaR BALAtmr
is: SBO:0000185
is described by: ECO:0000000
reversible: true
name: Beta-alanine reversible mitochondrial transport (diffusion)
fast: false
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 1 AUTHORS: PMID:15304357 NOTES:SAB
reactant: MODEL1310110063#
product: MODEL1310110063#
kinetic law: MODEL1310110063#

http://identifiers.org/biomodels.db/MODEL1310110063#_e880d6e0_0465_40a2_b71a_e152e5da0185
type: Species
constant: false
is: Q16831
is: SBO:0000252
name: UPP1
initial amount: NaN
initial concentration: NaN
boundary condition: true
is encoded by: hsa:7378
has only substance units: false

metaR GALASE3ly
reversible: false
name: beta-galactosidase, lysosomal
is version of: http://identifiers.org/ec-code/3.2.1.23
is: SBO:0000176
modifier: MODEL1310110063#
is described by: ECO:0000000
fast: false
product: MODEL1310110063#
is version of: http://identifiers.org/ec-code/3.2.1.18
type: Reaction
kinetic law: MODEL1310110063#
is version of: http://identifiers.org/ec-code/3.1.6.4
is version of: http://identifiers.org/ec-code/3.4.16.5
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) or (5476.1) and (2720.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.23 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD
reactant: MODEL1310110063#

metaM trdrd m
type: Species
notes: FORMULA: XH2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00289 EHMN_ABBREVIATION: C00342
is: CHEBI:15967
name: Reduced thioredoxin
constant: false
initial amount: NaN
initial concentration: 1.0
is: SBO:0000247
has only substance units: false
boundary condition: false

metaM CE2705 c
notes: FORMULA: C9H13N5O3 CHARGE: 0 INCHI: InChI=1/C9H13N5O3/c1-3(15)6(16)4-2-11-7-5(12-4)8(17)14-9(10)13-7/h3-4,6,15-16H,2H2,1H3,(H3,10,11,13,14,17)/p+1/t3-,4?,6+/m0/s1 EHMN_ABBREVIATION: CE2705
initial concentration: 1.0
constant: false
is: SBO:0000247
is: CHEBI:36781
initial amount: NaN
type: Species
has only substance units: false
name: quinonoid dihydrobiopterin
boundary condition: false

metaR FAOXC16BRx
kinetic law: MODEL1310110063#
product: MODEL1310110063#
reactant: MODEL1310110063#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid activation(C16br)x
type: Reaction

metaR AG13T12g
is version of: http://identifiers.org/ec-code/2.4.1.149
notes: GENE_ASSOCIATION: (79369.1) or (374907.1) or (11041.1) or (146712.1) or (374907.2) or (93010.1) or (10331.1) or (10678.1) or (10678.2) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.149 Confidence Level: 4 AUTHORS: PMID:10747980,PMID:11042166,PMID:12061784,PMID:12512857,PMID:15560372,PMID:15620693,PMID:9405606 NOTES:NCD
is: SBO:0000176
product: MODEL1310110063#
name: N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase, Golgi apparatus
reversible: false
reactant: MODEL1310110063#
is described by: ECO:0000000
type: Reaction
kinetic law: MODEL1310110063#
fast: false
modifier: MODEL1310110063#

metaM ksii core2 deg1 l
initial amount: NaN
boundary condition: false
is: CHEBI:57737
initial concentration: 1.0
name: keratan sulfate II (core 2-linked), degradation product 1
type: Species
constant: false
has only substance units: false
is: SBO:0000247
notes: FORMULA: C70H113N5O59S3X CHARGE: -3
is: HMDB00868

http://identifiers.org/biomodels.db/MODEL1310110063#_6b4b50ec_9577_4017_ad7e_37644420633b
is encoded by: hsa:79837
is: B3KQV3
type: Species
boundary condition: true
name: PIP4K2C
is: SBO:0000252
initial amount: NaN
has only substance units: false
constant: false
initial concentration: NaN

metaM for r
is: C00058
type: Species
has only substance units: false
notes: FORMULA: CH1O2 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00061 EHMN_ABBREVIATION: C00058
is: SBO:0000247
constant: false
is: CHEBI:15740
name: Formate
is: HMDB00142
initial amount: NaN
initial concentration: 1.0
boundary condition: false

metaR RE2626M
name: RE2626
fast: false
kinetic law: MODEL1310110063#
product: MODEL1310110063#
notes: GENE_ASSOCIATION: (1593.1) SUBSYSTEM: Bile acid synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:9210654,PMID:9660774 NOTES:
reversible: true
is: SBO:0000176
type: Reaction
is described by: ECO:0000000
reactant: MODEL1310110063#
modifier: MODEL1310110063#
is version of: http://identifiers.org/ec-code/1.14.13.15

metaR H4ETer
kinetic law: MODEL1310110063#
reactant: MODEL1310110063#
fast: false
product: MODEL1310110063#
modifier: MODEL1310110063#
is: SBO:0000176
notes: GENE_ASSOCIATION: (23556.1) or (23556.2) SUBSYSTEM: Phosphatidylinositol phosphate metabolism EC Number: Confidence Level: 2 AUTHORS: PMID:10574991 NOTES:NCD
type: Reaction
reversible: false
name: H4 phosphoethanolaminyl transferase, endoplasmic reticulum
is described by: ECO:0000000

metaR r0655
type: Reaction
modifier: MODEL1310110063#
fast: false
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (10637.1) or (5831.1) or (29920.1) or (65263.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 1.3.99.10 Confidence Level: 0 AUTHORS: PMID:3597357,PMID:9214289 NOTES:
is: SBO:0000176
name: 3-Methylbutanoyl-CoA:(acceptor) 2,3-oxidoreductase Valine, leucine and isoleucine degradation EC:1.3.99.10
product: MODEL1310110063#
is version of: http://identifiers.org/ec-code/1.5.1.2
kinetic law: MODEL1310110063#
reversible: true
reactant: MODEL1310110063#

metaR UMPK4n
is: SBO:0000176
reversible: true
modifier: MODEL1310110063#
is version of: http://identifiers.org/ec-code/2.7.4.14
reactant: MODEL1310110063#
is described by: ECO:0000269
fast: false
name: UMP kinase (GTP),nuclear
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
kinetic law: MODEL1310110063#
product: MODEL1310110063#
type: Reaction

metaR SIAASEly
reactant: MODEL1310110063#
name: sialidase, lysosomal
is: SBO:0000176
modifier: MODEL1310110063#
kinetic law: MODEL1310110063#
is version of: http://identifiers.org/ec-code/3.2.1.18
type: Reaction
is version of: http://identifiers.org/ec-code/3.2.1.23
is version of: http://identifiers.org/ec-code/3.4.16.5
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) SUBSYSTEM: N-glycan degradation EC Number: 3.2.1.18 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD
fast: false
is version of: http://identifiers.org/ec-code/3.1.6.4
product: MODEL1310110063#
reversible: false
is described by: ECO:0000000

metaR r1434
kinetic law: MODEL1310110063#
reversible: false
fast: false
type: Reaction
reactant: MODEL1310110063#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:12930836,PMID:16288981,PMID:911815 NOTES:
name: Transport reaction
product: MODEL1310110063#
is: SBO:0000185
is described by: ECO:0000000

metaM ins c
is: HMDB00195
name: Inosine
is: SBO:0000247
initial concentration: 1.0
constant: false
boundary condition: false
is: CHEBI:17596
has only substance units: false
notes: FORMULA: C10H12N4O5 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00255 EHMN_ABBREVIATION: C00294
initial amount: NaN
is: C00294
type: Species

http://identifiers.org/biomodels.db/MODEL1310110063#_d355151f_e913_49dd_98e3_a1c45671098c
has only substance units: false
initial amount: NaN
is encoded by: hsa:2224
is: SBO:0000252
type: Species
initial concentration: NaN
is: P14324
boundary condition: true
constant: false
name: FDPS

http://identifiers.org/biomodels.db/MODEL1310110063#_86b69a91_6e9f_4159_b2cb_586e25db5afd
is: P07741
has only substance units: false
boundary condition: true
type: Species
constant: false
initial amount: NaN
name: APRT
is encoded by: hsa:353
is: SBO:0000252
initial concentration: NaN

metaR DNDPt35m
product: MODEL1310110063#
fast: false
name: dGDP transport via dADP antiport
is described by: ECO:0000269
modifier: MODEL1310110063#
type: Reaction
is: SBO:0000185
kinetic law: MODEL1310110063#
notes: GENE_ASSOCIATION: (60386.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:11226231 NOTES:IT
reversible: false
reactant: MODEL1310110063#

metaR EX c81crn
kinetic law: MODEL1310110063#
reactant: MODEL1310110063#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for octenoyl carnitine
type: Reaction

metaM chsterol e
is: CHEBI:16113
has only substance units: false
name: cholesterol
boundary condition: false
constant: false
is: SBO:0000247
initial concentration: 1.0
notes: FORMULA: C27H46O CHARGE: 0 INCHI: InChI=1S/C27H46O/c1-18(2)7-6-8-19(3)23-11-12-24-22-10-9-20-17-21(28)13-15-26(20,4)25(22)14-16-27(23,24)5/h9,18-19,21-25,28H,6-8,10-17H2,1-5H3/t19-,21+,22+,23-,24+,25+,26+,27-/m1/s1
is: HMDB00067
type: Species
initial amount: NaN

metaR r1431
kinetic law: MODEL1310110063#
fast: false
is: SBO:0000176
product: MODEL1310110063#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 1.17.4.1 Confidence Level: 0 AUTHORS: PMID:5553404,PMID:5671058 NOTES:
reversible: false
reactant: MODEL1310110063#
name: 2-Deoxyuridine 5-diphosphate:oxidized-thioredoxin 2-oxidoreductase Pyrimidine metabolism EC:1.17.4.1
is described by: ECO:0000000

metaR sink octdececoa LPAREN c RPAREN
kinetic law: MODEL1310110063#
reactant: MODEL1310110063#
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: OCTDECECOASINK
type: Reaction

metaR PI3P3Pn
fast: false
kinetic law: MODEL1310110063#
type: Reaction
reactant: MODEL1310110063#
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Inositol phosphate metabolism EC Number: Confidence Level: 2 AUTHORS: PMID:12728269 NOTES:EC 3.1.3.- NCD
name: phosphatidylinositol-3-phosphate 3-phosphatase, nuclear
reversible: false
product: MODEL1310110063#
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110063#_47741075_7c5f_47a2_949f_d717923d42bf
name: FDFT1
boundary condition: true
has only substance units: false
is encoded by: hsa:2222
initial amount: NaN
type: Species
initial concentration: NaN
is: P37268
is: SBO:0000252
constant: false

http://identifiers.org/biomodels.db/MODEL1310110063#_f506c134_29d6_44d4_9cc4_2b85b8684c3a
constant: false
name: SLC2A4
initial amount: NaN
initial concentration: NaN
has only substance units: false
boundary condition: true
is encoded by: hsa:6517
is: SBO:0000252
type: Species
is: P14672

metaM ksii core4 pre10 g
initial concentration: 1.0
is: SBO:0000247
boundary condition: false
constant: false
has only substance units: false
initial amount: NaN
name: keratan sulfate II biosynthesis, precursor 10
notes: FORMULA: C89H143N7O69S2X CHARGE: -3
is: CHEBI:28067
type: Species

http://identifiers.org/biomodels.db/MODEL1310110063#_d8e6a34e_252e_443f_beb8_00af992d3527
constant: false
initial amount: NaN
is: SBO:0000252
boundary condition: true
name: AKR1A1
is: P14550
initial concentration: NaN
type: Species
has only substance units: false
is encoded by: hsa:10327

metaR PI45P3K
kinetic law: MODEL1310110063#
fast: false
modifier: MODEL1310110063#
reversible: false
reactant: MODEL1310110063#
type: Reaction
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.7.11.1
is version of: http://identifiers.org/ec-code/2.7.1.153
notes: GENE_ASSOCIATION: (5291.1 and 5295.3) or (5293.1 and 8503.1) or (5296.1 and 5290.1) or (5293.1 and 5295.1) or (5293.1 and 5295.3) or (5291.1 and 5295.1) or (5296.1 and 5291.1) or (5295.2 and 5290.1) or (10870.1 and 5294.1) or (23533.1 and 5294.1) or (5295.2 and 5293.1) or (5290.1 and 5295.1) or (5290.1 and 8503.1) or (5290.1 and 5295.3) or (5291.1 and 8503.1) or (5293.1 and 5296.1) or (5295.2 and 5291.1) SUBSYSTEM: Inositol phosphate metabolism EC Number: 2.7.1.153 Confidence Level: 4 AUTHORS: PMID:12507995,PMID:15780590,PMID:2174051,PMID:7624799,PMID:7713498,PMID:8246984,PMID:9113989 NOTES:NCD
is described by: ECO:0000000
name: phosphatidylinositol 4,5-bisphosphate 3-kinase
product: MODEL1310110063#

metaM octdececrn c
notes: FORMULA: C25H47NO4 CHARGE: 0
constant: false
initial concentration: 1.0
is: HMDB06351
type: Species
initial amount: NaN
boundary condition: false
name: octadecenoyl carnitine (hypothetical, position of double bond unknown)
is: SBO:0000247
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110063#_c2eb82c2_252e_4a6f_849c_d1a066eee083
type: Species
is encoded by: hsa:5150
initial amount: NaN
boundary condition: true
constant: false
has only substance units: false
is: SBO:0000252
name: PDE7A
initial concentration: NaN

metaR RE2954C
is: SBO:0000176
kinetic law: MODEL1310110063#
type: Reaction
name: RE2954
reversible: true
is version of: http://identifiers.org/ec-code/2.7.1.40
product: MODEL1310110063#
fast: false
notes: GENE_ASSOCIATION: (5315.1) SUBSYSTEM: Pyrimidine synthesis EC Number: 2.7.1.40 Confidence Level: 0 AUTHORS: PMID:10585400,PMID:8967971 NOTES:
modifier: MODEL1310110063#
is described by: ECO:0000000
reactant: MODEL1310110063#

metaM retinal cis 9 r
initial concentration: 1.0
is: CHEBI:17898
has only substance units: false
initial amount: NaN
name: all-trans-retinal
type: Species
is: SBO:0000247
boundary condition: false
constant: false
is: HMDB01358
notes: FORMULA: C20H28O CHARGE: 0 INCHI: InChI=1S/C20H28O/c1-16(8-6-9-17(2)13-15-21)11-12-19-18(3)10-7-14-20(19,4)5/h6,8-9,11-13,15H,7,10,14H2,1-5H3/b9-6+,12-11+,16-8+,17-13+ EHMN_ABBREVIATION: CE5575

metaR r0653
reactant: MODEL1310110063#
fast: false
type: Reaction
name: myristoyl-CoA:acetylCoA C-myristoyltransferase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:2.3.1.16
is described by: ECO:0000000
product: MODEL1310110063#
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.16 Confidence Level: 0 AUTHORS: PMID:10706581,PMID:1121274,PMID:1679347,PMID:3194209,PMID:6378901,PMID:8241273 NOTES:
kinetic law: MODEL1310110063#
reversible: false

metaR ATPtm
is: SBO:0000185
type: Reaction
fast: false
reversible: false
product: MODEL1310110063#
modifier: MODEL1310110063#
kinetic law: MODEL1310110063#
is described by: ECO:0000269
name: ADP/ATP transporter, mitochondrial
notes: GENE_ASSOCIATION: (291.1) or (293.1) or (292.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172 NOTES:NCD
reactant: MODEL1310110063#

metaR RE2649C
modifier: MODEL1310110063#
fast: false
type: Reaction
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/3.1.2.2
notes: GENE_ASSOCIATION: (641372.1) or (641371.1) or (570.1) SUBSYSTEM: Bile acid synthesis EC Number: 3.1.2.2 Confidence Level: 0 AUTHORS: PMID:11013297 NOTES:
reactant: MODEL1310110063#
reversible: true
is: SBO:0000176
name: RE2649
product: MODEL1310110063#
is version of: http://identifiers.org/ec-code/2.3.1.65
kinetic law: MODEL1310110063#

metaR HDCEAtr
is: SBO:0000185
name: fatty acid transport via diffusion
product: MODEL1310110063#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11788354,PMID:12864740 NOTES:NJ
reactant: MODEL1310110063#
is described by: ECO:0000000
kinetic law: MODEL1310110063#
reversible: true
fast: false
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110063#_aa7498a1_89be_4108_979a_3b679df98c3a
name: ACSL3
boundary condition: true
initial amount: NaN
is encoded by: hsa:2181
is: SBO:0000252
has only substance units: false
type: Species
is: O95573
constant: false
initial concentration: NaN

metaR CITL
modifier: MODEL1310110063#
type: Reaction
is: SBO:0000176
name: Citrate lyase
product: MODEL1310110063#
reactant: MODEL1310110063#
reversible: false
notes: GENE_ASSOCIATION: (171425.1) or (171425.2) SUBSYSTEM: Citric acid cycle EC Number: 4.1.3.6 Confidence Level: 0 AUTHORS: PMID:11741334 NOTES:JLR
fast: false
kinetic law: MODEL1310110063#
is described by: ECO:0000000

metaM ahcys c
constant: false
type: Species
notes: FORMULA: C14H20N6O5S CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00031 EHMN_ABBREVIATION: C00021
has only substance units: false
is: CHEBI:16680
initial concentration: 1.0
is: HMDB00939
is: SBO:0000247
is: C00021
boundary condition: false
initial amount: NaN
name: S-Adenosyl-L-homocysteine

metaR UDPGLCter
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: PMID:10369669 NOTES:NCD
is: SBO:0000185
type: Reaction
product: MODEL1310110063#
fast: false
reactant: MODEL1310110063#
is described by: ECO:0000000
reversible: true
name: UDP-Glc endoplasmic reticulum transport via CMP antiport
kinetic law: MODEL1310110063#

http://identifiers.org/biomodels.db/MODEL1310110063#_4c96ae26_93da_4e54_b79c_b6ad581c258d
is: SBO:0000297
is encoded by: hsa:593
has only substance units: false
initial concentration: NaN
has part: P21953
initial amount: NaN
is encoded by: hsa:1629
has part: B4DP47
constant: false
name: DBT:DLD:BCKDHA:BCKDHB
has part: P11182
boundary condition: true
is encoded by: hsa:594
type: Species

metaM HC01842 c
name: Phosphodimethylethanolamine
initial amount: NaN
notes: FORMULA: C4H10NO4P CHARGE: -2 INCHI: InChI=1S/C4H12NO4P/c1-5(2)3-4-9-10(6,7)8/h3-4H2,1-2H3,(H2,6,7,8)
is: SBO:0000247
has only substance units: false
is: CHEBI:31997
type: Species
initial concentration: 1.0
constant: false
boundary condition: false

metaR RIBt
product: MODEL1310110063#
is described by: ECO:0000000
reactant: MODEL1310110063#
is: SBO:0000185
fast: false
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:15234337 NOTES:NCD
name: ribose transport via diffusion
type: Reaction
kinetic law: MODEL1310110063#

metaR FAOXC101x
kinetic law: MODEL1310110063#
product: MODEL1310110063#
reactant: MODEL1310110063#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: isomerization(C10:1)x
type: Reaction

metaM dopasf e
boundary condition: false
initial concentration: 1.0
constant: false
is: HMDB06275
is: SBO:0000247
notes: FORMULA: C8H11NO5S CHARGE: 0 INCHI: InChI=1S/C8H11NO5S/c9-4-3-6-1-2-7(10)8(5-6)14-15(11,12)13/h1-2,5,10H,3-4,9H2,(H,11,12,13) EHMN_ABBREVIATION: C13690
has only substance units: false
type: Species
initial amount: NaN
is: CHEBI:37946
name: dopamine 3-O-sulfate

metaR FTHFL
type: Reaction
reactant: MODEL1310110063#
modifier: MODEL1310110063#
name: Formate-tetrahydrofolate ligase
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.5.1.5
is described by: ECO:0000134
product: MODEL1310110063#
reversible: true
fast: false
notes: GENE_ASSOCIATION: (4522.1) or (286297.1) SUBSYSTEM: Folate metabolism EC Number: Confidence Level: 4 AUTHORS: NOTES:
kinetic law: MODEL1310110063#

http://identifiers.org/biomodels.db/MODEL1310110063#_30ad6041_834c_43de_af53_965a291fe7c0
is: F5H2Y9
name: ALDH1A2
type: Species
boundary condition: true
is encoded by: hsa:8854
initial concentration: NaN
constant: false
has only substance units: false
initial amount: NaN
is: SBO:0000252

metaM nh4 e
constant: false
is: CHEBI:28938
type: Species
boundary condition: false
is: SBO:0000247
notes: FORMULA: H4N CHARGE: 1 INCHI: InChI=1S/H3N/h1H3/p+1 HEPATONET_1.0_ABBREVIATION: HC00765 EHMN_ABBREVIATION: C01342
name: ammonium
is: HMDB00051
initial concentration: 1.0
has only substance units: false
initial amount: NaN

metaM ksii core4 pre9 g
type: Species
is: CHEBI:28067
name: keratan sulfate II biosynthesis, precursor 9
initial amount: NaN
has only substance units: false
is: SBO:0000247
constant: false
initial concentration: 1.0
boundary condition: false
notes: FORMULA: C83H133N7O64S2X CHARGE: -3

metaR NCNt
name: Na+/Ca2+-NH4+ exchange
kinetic law: MODEL1310110063#
fast: false
reactant: MODEL1310110063#
product: MODEL1310110063#
is described by: ECO:0000269
modifier: MODEL1310110063#
reversible: true
is: SBO:0000185
notes: GENE_ASSOCIATION: (9187.1) or (25769.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10484410,PMID:10662833,PMID:11294880,PMID:12379639,PMID:14770312,PMID:9478004 NOTES:NCD
type: Reaction

metaR HAS2
fast: false
reversible: false
product: MODEL1310110063#
name: hyaluronan synthase
notes: GENE_ASSOCIATION: (3038.2) or (3036.1) or (3038.1) or (3037.1) SUBSYSTEM: Hyaluronan metabolism EC Number: 2.4.1.212 Confidence Level: 4 AUTHORS: PMID:12512858,PMID:8651928,PMID:8798477,PMID:8798544,PMID:9083017 NOTES:NCD
reactant: MODEL1310110063#
type: Reaction
modifier: MODEL1310110063#
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/2.4.1.212
kinetic law: MODEL1310110063#
is: SBO:0000185

metaR r0483
type: Reaction
name: (R)-3-Amino-2-methylpropanoate:2-oxoglutarate aminotransferase EC:2.6.1.22
notes: GENE_ASSOCIATION: SUBSYSTEM: Pyrimidine catabolism EC Number: 2.6.1.22 Confidence Level: 0 AUTHORS: PMID:5773299 NOTES:
is: SBO:0000176
is described by: ECO:0000000
reversible: true
reactant: MODEL1310110063#
kinetic law: MODEL1310110063#
fast: false
product: MODEL1310110063#

metaR DM datp m
kinetic law: MODEL1310110063#
reactant: MODEL1310110063#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 0 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: false
name: dATP demand
type: Reaction

metaR FAOXC2031836m
modifier: MODEL1310110063#
is described by: ECO:0000269
is: SBO:0000176
product: MODEL1310110063#
notes: GENE_ASSOCIATION: (35.1) or (34.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.74 Confidence Level: 4 AUTHORS: NOTES:c20:3 -> c18:3 4 step FAO lumped also includes EC 1.1.1.35, 1.1.1.211, 1.3.3.6, 4.2.1.17, 4.2.1.74 NJ
type: Reaction
reversible: false
is version of: http://identifiers.org/ec-code/1.3.8.1
name: Beta oxidation of fatty acid
reactant: MODEL1310110063#
fast: false
is version of: http://identifiers.org/ec-code/1.3.99.3
kinetic law: MODEL1310110063#

http://identifiers.org/biomodels.db/MODEL1310110063#_d8a7a77e_2997_4073_a8fa_6511cb582bdf
constant: false
type: Species
initial amount: NaN
is: SBO:0000252
has only substance units: false
name: SLC9A3
is: P48764
boundary condition: true
is encoded by: hsa:6550
initial concentration: NaN

metaR GALASE16ly
reversible: false
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) or (5476.1) and (2720.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.23 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD
product: MODEL1310110063#
is described by: ECO:0000000
reactant: MODEL1310110063#
type: Reaction
name: beta-galactosidase, lysosomal
kinetic law: MODEL1310110063#
is version of: http://identifiers.org/ec-code/3.2.1.23
is version of: http://identifiers.org/ec-code/3.2.1.18
fast: false
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.4.16.5
is version of: http://identifiers.org/ec-code/3.1.6.4
modifier: MODEL1310110063#

metaM dgchol e
constant: false
has only substance units: false
type: Species
initial amount: NaN
notes: FORMULA: C26H43NO5 CHARGE: 0 INCHI: InChI=1S/C26H43NO5/c1-15(4-7-22(30)27-14-23(31)32)18-5-6-19-24-20(9-11-26(18,19)3)25(2)10-8-17(28)12-16(25)13-21(24)29/h15-21,24,28-29H,4-14H2,1-3H3,(H,27,30)(H,31,32)/p-1/t15-,16+,17-,18-,19+,20+,21-,24+,25+,26-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01472
is: CHEBI:36252
is: SBO:0000247
name: glycochenodeoxycholate
initial concentration: 1.0
boundary condition: false
is: HMDB00637

metaR VLCS2r
is: SBO:0000176
is described by: ECO:0000304
type: Reaction
is version of: http://identifiers.org/ec-code/6.2.1.3
fast: false
modifier: MODEL1310110063#
kinetic law: MODEL1310110063#
name: Very-long-chain-fatty-acid-CoA ligase
product: MODEL1310110063#
notes: GENE_ASSOCIATION: (11001.1) SUBSYSTEM: Bile acid synthesis EC Number: 6.2.1.7 Confidence Level: 2 AUTHORS: NOTES:from uniprot and lit - see human recon lit refs divalent cation requirement - unclear which one, reaction inhibited in the presence of EDTA (may just be MgATP or MgATP) - see Kelley and Vessey Biochimica et Biophysica Acta (1994) 1209: 51-55 temporarily will have H+ balance reaction NJ
reversible: false
reactant: MODEL1310110063#

http://identifiers.org/biomodels.db/MODEL1310110063#_3e24f49d_558c_4016_8842_4e1b297b4deb
name: LTA4H
has only substance units: false
boundary condition: true
type: Species
is encoded by: hsa:4048
is: SBO:0000252
initial concentration: NaN
is: P09960
constant: false
initial amount: NaN

metaM lys L m
initial concentration: 1.0
is: SBO:0000247
is: CHEBI:32551
constant: false
has only substance units: false
notes: FORMULA: C6H15N2O2 CHARGE: 1 INCHI: InChI=1S/C6H14N2O2/c7-4-2-1-3-5(8)6(9)10/h5H,1-4,7-8H2,(H,9,10)/p+1/t5-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00053 EHMN_ABBREVIATION: C00047
boundary condition: false
type: Species
initial amount: NaN
name: L-lysinium(1+)
is: HMDB00182

metaM crn m
name: L-Carnitine
has only substance units: false
initial concentration: 1.0
is: SBO:0000247
type: Species
constant: false
boundary condition: false
is: C00318
notes: FORMULA: C7H15NO3 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00270 EHMN_ABBREVIATION: C00318
is: HMDB00062
initial amount: NaN
is: CHEBI:16347

metaM HC01118 r
name: presqualene diphosphate(3-)
is: SBO:0000247
type: Species
initial concentration: 1.0
notes: FORMULA: C30H49O7P2 CHARGE: -3 INCHI: InChI=1S/C30H52O7P2/c1-23(2)13-9-15-25(5)17-11-18-27(7)21-28-29(22-36-39(34,35)37-38(31,32)33)30(28,8)20-12-19-26(6)16-10-14-24(3)4/h13-14,17,19,21,28-29H,9-12,15-16,18,20,22H2,1-8H3,(H,34,35)(H2,31,32,33)/p-3/b25-17+,26-19+,27-21+/t28-,29-,30-/m0/s1 EHMN_ABBREVIATION: C03428
boundary condition: false
is: CHEBI:57310
has only substance units: false
constant: false
initial amount: NaN

metaR S6TASE10ly
reversible: true
is version of: http://identifiers.org/ec-code/3.2.1.23
is version of: http://identifiers.org/ec-code/3.1.6.4
product: MODEL1310110063#
is: SBO:0000176
fast: false
reactant: MODEL1310110063#
modifier: MODEL1310110063#
kinetic law: MODEL1310110063#
is version of: http://identifiers.org/ec-code/3.2.1.18
type: Reaction
is version of: http://identifiers.org/ec-code/3.4.16.5
is described by: ECO:0000000
name: galactose-6-sulfate sulfatase, lysosomal
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.1.6.4 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD

metaM ahcys e
is: SBO:0000247
is: C00021
constant: false
boundary condition: false
type: Species
initial concentration: 1.0
is: CHEBI:16680
name: S-Adenosyl-L-homocysteine
initial amount: NaN
notes: FORMULA: C14H20N6O5S CHARGE: 0
is: HMDB00939
has only substance units: false

metaR DHORTS
type: Reaction
reactant: MODEL1310110063#
name: dihydroorotase
kinetic law: MODEL1310110063#
is version of: http://identifiers.org/ec-code/2.1.3.2
modifier: MODEL1310110063#
reversible: true
product: MODEL1310110063#
is: SBO:0000176
notes: GENE_ASSOCIATION: (790.1) SUBSYSTEM: Pyrimidine synthesis EC Number: 3.5.2.3 Confidence Level: 4 AUTHORS: PMID:2565865,PMID:8619816 NOTES:
fast: false
is described by: ECO:0000269

metaR LSTO1r
notes: GENE_ASSOCIATION: (6309.1) SUBSYSTEM: Cholesterol metabolism EC Number: 1.3.3.2 Confidence Level: 4 AUTHORS: PMID:10344195 NOTES:lanosterol -> cholesterol pathway NJ
is version of: http://identifiers.org/ec-code/1.14.21.6
is described by: ECO:0000269
name: Lathosterol oxidase
reactant: MODEL1310110063#
modifier: MODEL1310110063#
fast: false
reversible: false
kinetic law: MODEL1310110063#
product: MODEL1310110063#
is: SBO:0000176
type: Reaction

metaM ha deg1 l
boundary condition: false
name: hyaluronan degradation product 1
is: CHEBI:16336
initial concentration: 1.0
is: SBO:0000247
notes: FORMULA: C22H33N2O16 CHARGE: -1
constant: false
initial amount: NaN
type: Species
has only substance units: false

metaM nh4 c
is: C01342
is: SBO:0000247
initial amount: NaN
is: CHEBI:28938
has only substance units: false
name: Ammonium
notes: FORMULA: H4N CHARGE: 1 HEPATONET_1.0_ABBREVIATION: HC00765 EHMN_ABBREVIATION: C01342
boundary condition: false
constant: false
initial concentration: 1.0
is: HMDB00051
type: Species

metaR r1435
is: SBO:0000185
kinetic law: MODEL1310110063#
name: Transport reaction
product: MODEL1310110063#
type: Reaction
reversible: false
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:12930836,PMID:16288981,PMID:911815 NOTES:
reactant: MODEL1310110063#
is described by: ECO:0000000

metaR NACHEX12ly
is version of: http://identifiers.org/ec-code/3.2.1.52
reactant: MODEL1310110063#
product: MODEL1310110063#
reversible: false
type: Reaction
name: beta-N-acetylhexosaminidase, lysosomal
fast: false
notes: GENE_ASSOCIATION: (3074.1) or (3073.1) or (3073.1 and 3074.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.52 Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12706724,PMID:8993162 NOTES:NCD
is described by: ECO:0000000
modifier: MODEL1310110063#
is: SBO:0000176
kinetic law: MODEL1310110063#

metaM lys L n
constant: false
has only substance units: false
initial amount: NaN
initial concentration: 1.0
type: Species
is: CHEBI:32551
boundary condition: false
notes: FORMULA: C6H15N2O2 CHARGE: 1 INCHI: InChI=1S/C6H14N2O2/c7-4-2-1-3-5(8)6(9)10/h5H,1-4,7-8H2,(H,9,10)/p+1/t5-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00053 EHMN_ABBREVIATION: C00047
is: HMDB00182
is: SBO:0000247
name: L-lysinium(1+)

http://identifiers.org/biomodels.db/MODEL1310110063#_5bfb5a88_4acb_43e1_aa43_c093ef7268b4
is: P04745
constant: false
initial concentration: NaN
type: Species
has only substance units: false
is: SBO:0000252
boundary condition: true
initial amount: NaN
is encoded by: hsa:278
name: AMY1C

metaM cs e deg6 l
boundary condition: false
is: HMDB01354
constant: false
name: chondroitin sulfate E (GalNAc4,6diS-GlcA), degradation product 6
is: CHEBI:57455
initial concentration: 1.0
notes: FORMULA: C31H48NO32S2 CHARGE: -3
type: Species
is: SBO:0000247
initial amount: NaN
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110063#_680855b2_d93c_4bd8_97a6_3fe5d24763f2
type: Species
initial concentration: NaN
has only substance units: false
is encoded by: hsa:10797
boundary condition: true
is: SBO:0000252
is: P13995
constant: false
name: MTHFD2
initial amount: NaN

metaR VLCS2p
kinetic law: MODEL1310110063#
modifier: MODEL1310110063#
reactant: MODEL1310110063#
name: Very-long-chain-fatty-acid-CoA ligase
is: SBO:0000176
is described by: ECO:0000304
fast: false
type: Reaction
reversible: false
product: MODEL1310110063#
notes: GENE_ASSOCIATION: (11001.1) SUBSYSTEM: Bile acid synthesis EC Number: 6.2.1.7 Confidence Level: 2 AUTHORS: PMID:10479480 NOTES:from uniprot and lit - see human recon lit refs divalent cation requirement - unclear which one, reaction inhibited in the presence of EDTA (may just be MgATP or MgATP) - see Kelley and Vessey Biochimica et Biophysica Acta (1994) 1209: 51-55 temporarily will have H+ balance reaction NJ
is version of: http://identifiers.org/ec-code/6.2.1.3

metaR TYRPHELAT2tc
kinetic law: MODEL1310110063#
product: MODEL1310110063#
reactant: MODEL1310110063#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of L-Tyrosine into the cell and efflux of L-Phenylalanine out of the cell by LAT2 on the basolateral surfaces of kidney and intestine.
type: Reaction

metaR LEUKTRB4t
name: leukotriene B4 transport
is described by: ECO:0000000
kinetic law: MODEL1310110063#
reversible: true
reactant: MODEL1310110063#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:
is: SBO:0000185
fast: false
product: MODEL1310110063#
type: Reaction

metaR PHEACGLNt
type: Reaction
reversible: true
reactant: MODEL1310110063#
product: MODEL1310110063#
name: PHEACGLN extracellular transport via diffusion
kinetic law: MODEL1310110063#
fast: false
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14681857 NOTES:SAB
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110063#_e4c2bea9_baf2_456f_9d46_7aaf619720c8
is encoded by: hsa:622
boundary condition: true
is: SBO:0000252
initial concentration: NaN
constant: false
initial amount: NaN
name: BDH1
type: Species
has only substance units: false

metaM 3tetd7ecoa m
is: HMDB05066
type: Species
notes: FORMULA: C35H56N7O18P3S CHARGE: -4
is: SBO:0000247
initial concentration: 1.0
boundary condition: false
initial amount: NaN
constant: false
name: 3-hydroxy tetradecenoyl-7-coa
has only substance units: false

metaM octe5coa m
is: http://identifiers.org/pubchem.compound/16019966
initial amount: NaN
is: SBO:0000247
boundary condition: false
constant: false
initial concentration: 1.0
notes: FORMULA: C29H44N7O17P3S CHARGE: -4
type: Species
name: 5-octenoylcoa
has only substance units: false

metaM ins e
is: C00294
type: Species
name: Inosine
is: HMDB00195
is: CHEBI:17596
has only substance units: false
boundary condition: false
initial amount: NaN
initial concentration: 1.0
is: SBO:0000247
constant: false
notes: FORMULA: C10H12N4O5 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00255 EHMN_ABBREVIATION: C00294

metaR ARACHDtr
product: MODEL1310110063#
type: Reaction
reversible: true
reactant: MODEL1310110063#
is: SBO:0000185
fast: false
kinetic law: MODEL1310110063#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: NOTES:unknown mechanism, presumed diffusion NJ
name: intracellular transport

metaM dgchol c
name: glycochenodeoxycholate
notes: FORMULA: C26H43NO5 CHARGE: 0 INCHI: InChI=1S/C26H43NO5/c1-15(4-7-22(30)27-14-23(31)32)18-5-6-19-24-20(9-11-26(18,19)3)25(2)10-8-17(28)12-16(25)13-21(24)29/h15-21,24,28-29H,4-14H2,1-3H3,(H,27,30)(H,31,32)/p-1/t15-,16+,17-,18-,19+,20+,21-,24+,25+,26-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01472
initial amount: NaN
is: SBO:0000247
initial concentration: 1.0
boundary condition: false
has only substance units: false
is: CHEBI:36252
is: HMDB00637
type: Species
constant: false

metaM clpnd c
is: CHEBI:53488
initial concentration: 1.0
is: SBO:0000247
name: clupanodonic acid
type: Species
has only substance units: false
constant: false
is: HMDB06528
notes: FORMULA: C22H33O2 CHARGE: -1 INCHI: InChI=1S/C22H34O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22(23)24/h3-4,6-7,9-10,12-13,15-16H,2,5,8,11,14,17-21H2,1H3,(H,23,24)/b4-3-,7-6-,10-9-,13-12-,16-15-
initial amount: NaN
boundary condition: false

metaR r0488
reactant: MODEL1310110063#
fast: false
is: SBO:0000176
is described by: ECO:0000000
kinetic law: MODEL1310110063#
notes: GENE_ASSOCIATION: SUBSYSTEM: Cholesterol metabolism EC Number: 1.1.1.34 Confidence Level: 0 AUTHORS: PMID:10698924,PMID:11108725,PMID:12454262,PMID:3745272,PMID:3883347 NOTES:
reversible: true
product: MODEL1310110063#
type: Reaction
name: (R)-Mevalonate:NADP+ oxidoreductase (CoA acylating) Biosynthesis of steroids EC:1.1.1.34

metaR r1865
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
kinetic law: MODEL1310110063#
modifier: MODEL1310110063#
reactant: MODEL1310110063#
reversible: false
name: Y+LAT2 Utilized transport
type: Reaction
is described by: ECO:0000000
fast: false
is: SBO:0000185
product: MODEL1310110063#

metaR EX malthx LPAREN e RPAREN
kinetic law: MODEL1310110063#
reactant: MODEL1310110063#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Maltohexaose exchange
type: Reaction

metaR SUCOAS1m
name: Succinate--CoA ligase (GDP-forming)
is: SBO:0000176
reversible: true
notes: GENE_ASSOCIATION: (8802.1 and 8801.1) SUBSYSTEM: Citric acid cycle EC Number: 6.2.1.4 Confidence Level: 0 AUTHORS: PMID:9765291 NOTES:IF
is described by: ECO:0000000
fast: false
type: Reaction
kinetic law: MODEL1310110063#
reactant: MODEL1310110063#
is version of: http://identifiers.org/ec-code/6.2.1.4
product: MODEL1310110063#
modifier: MODEL1310110063#

metaM aicar e
boundary condition: false
is: SBO:0000247
is: HMDB01517
has only substance units: false
constant: false
is: CHEBI:58475
type: Species
is: C04677
notes: FORMULA: C9H13N4O8P CHARGE: -2
initial amount: NaN
initial concentration: 1.0
name: 5-Amino-1-(5-Phospho-D-ribosyl)imidazole-4-carboxamide

metaM bildglcur e
notes: FORMULA: C45H50N4O18 CHARGE: -2 INCHI: InChI=1S/C45H52N4O18/c1-7-20-19(6)40(58)49-27(20)14-25-18(5)23(10-12-31(51)65-45-37(57)33(53)35(55)39(67-45)43(62)63)29(47-25)15-28-22(17(4)24(46-28)13-26-16(3)21(8-2)41(59)48-26)9-11-30(50)64-44-36(56)32(52)34(54)38(66-44)42(60)61/h7-8,13-14,32-39,44-47,52-57H,1-2,9-12,15H2,3-6H3,(H,48,59)(H,49,58)(H,60,61)(H,62,63)/p-2/b26-13+,27-14+/t32-,33-,34-,35-,36+,37+,38-,39-,44+,45+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01616 EHMN_ABBREVIATION: C05787
is: HMDB03325
name: bis(beta-glucosyluronate)bilirubin
has only substance units: false
boundary condition: false
initial amount: NaN
is: SBO:0000247
constant: false
initial concentration: 1.0
type: Species
is: CHEBI:58471

http://identifiers.org/biomodels.db/MODEL1310110063#_bc64b1cf_78c2_40a2_9ab1_094cf9789f5f
is encoded by: hsa:124
boundary condition: true
has part: P07327
is: SBO:0000297
is encoded by: hsa:125
type: Species
initial amount: NaN
has part: P00325
has only substance units: false
initial concentration: NaN
constant: false
name: ADH1A:ADH1B

http://identifiers.org/biomodels.db/MODEL1310110063#_4ec5dcce_eb14_4725_a7c4_7ee3f64414ee
is: A8K0T6
is: SBO:0000252
is encoded by: hsa:55512
has only substance units: false
constant: false
initial amount: NaN
boundary condition: true
initial concentration: NaN
name: SMPD3
type: Species

metaM ksi deg17 l
constant: false
notes: FORMULA: C152H245N10O132S7 CHARGE: -7
is: CHEBI:12936
boundary condition: false
initial amount: NaN
initial concentration: 1.0
has only substance units: false
name: keratan sulfate I, degradation product 17
type: Species
is: SBO:0000247
is: HMDB00143

http://identifiers.org/biomodels.db/MODEL1310110063#_b3d9095a_b85a_4de6_99ba_298805386729
constant: false
has only substance units: false
is: O15254
is encoded by: hsa:8310
boundary condition: true
type: Species
initial concentration: NaN
initial amount: NaN
name: ACOX3
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110063#_b64da0b1_b30f_4870_ab53_e0fc363d3b6f
boundary condition: true
initial amount: NaN
constant: false
has only substance units: false
name: _728637_1_c
is: SBO:0000252
is encoded by: hsa:728637
type: Species
initial concentration: NaN

metaR r1866
fast: false
is: SBO:0000185
product: MODEL1310110063#
name: Y+LAT2 Utilized transport
kinetic law: MODEL1310110063#
is described by: ECO:0000000
type: Reaction
reactant: MODEL1310110063#
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reversible: false
modifier: MODEL1310110063#

metaR EX tetdec2crn
kinetic law: MODEL1310110063#
reactant: MODEL1310110063#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for tetradecadienoyl carnitine
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110063#_1f4e3ffb_902b_4c2a_8704_2d10e9238cc1
is: SBO:0000252
boundary condition: true
constant: false
type: Species
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:AA177072
name: _AA177072_1_c
has only substance units: false

metaR ACACt2m
reactant: MODEL1310110063#
fast: false
type: Reaction
modifier: MODEL1310110063#
reversible: true
name: Acetoacetate mitochondrial transport via H+ symport
is described by: ECO:0000269
kinetic law: MODEL1310110063#
product: MODEL1310110063#
notes: GENE_ASSOCIATION: (6566.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:28726,PMID:627555 NOTES:IT, TDV changed name from "tm2" to "t2m" - NCD
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110063#_b793fb22_b4b7_4dd7_8faf_c20efcba6bfe
initial amount: NaN
initial concentration: NaN
has only substance units: false
boundary condition: true
is: Q99519
constant: false
is encoded by: hsa:4758
type: Species
name: NEU1
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110063#_32c588c8_8d30_42b5_b794_053f0ae52de4
is: SBO:0000252
is encoded by: hsa:109
boundary condition: true
name: ADCY3
initial concentration: NaN
constant: false
type: Species
initial amount: NaN
is: B3KT86
has only substance units: false

metaR KCCt
is: SBO:0000185
modifier: MODEL1310110063#
kinetic law: MODEL1310110063#
notes: GENE_ASSOCIATION: (10723.1) or (57468.1) or (9990.1) or (6560.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10187864,PMID:10347194,PMID:10600773,PMID:121106695,PMID:12657561,PMID:12739168,PMID:8663127 NOTES:NCD
reactant: MODEL1310110063#
name: K+-Cl- cotransport
fast: false
reversible: true
product: MODEL1310110063#
is described by: ECO:0000269
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110063#_7858fa13_3675_4cfb_8ea5_871534f181a1
constant: false
has only substance units: false
initial amount: NaN
name: _AA502753_1_m
is encoded by: hsa:AA502753
type: Species
is: SBO:0000252
initial concentration: NaN
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110063#_4b357dfe_a7e8_4d3f_91e6_072650d425f0
is: P09172
type: Species
boundary condition: true
is: SBO:0000252
is encoded by: hsa:1621
name: DBH
constant: false
has only substance units: false
initial amount: NaN
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110063#_3bb61865_e4b1_44ae_9de6_57eee3777460
initial concentration: NaN
is encoded by: hsa:642502
name: _642502_1_c
has only substance units: false
constant: false
initial amount: NaN
is: SBO:0000252
boundary condition: true
type: Species

metaR ITPtn
fast: false
name: ITP nuclear transport
type: Reaction
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: NOTES:IT
reactant: MODEL1310110063#
product: MODEL1310110063#
reversible: true
kinetic law: MODEL1310110063#
is: SBO:0000185

metaR r0377
product: MODEL1310110063#
is version of: http://identifiers.org/ec-code/2.7.4.3
is: SBO:0000176
fast: false
is described by: ECO:0000000
modifier: MODEL1310110063#
name: ATP:deoxycitidine 5-phosphotransferase Pyrimidine metabolism EC:2.7.1.74
reversible: false
reactant: MODEL1310110063#
kinetic law: MODEL1310110063#
type: Reaction
notes: GENE_ASSOCIATION: (AI653169.1) or (203.1) or (204.1) or (205.1) or (206.1) or (26289.1) or (122481.1) or (AW277253.1) SUBSYSTEM: Pyrimidine catabolism EC Number: 2.7.1.74 Confidence Level: 0 AUTHORS: PMID:12036920,PMID:1657002,PMID:213049,PMID:8399394,PMID:9342341,PMID:9593124 NOTES:

metaR APAT2rm
reactant: MODEL1310110063#
name: 3-Aminopropanoate:2-oxoglutarate aminotransferase (m)
reversible: true
fast: false
kinetic law: MODEL1310110063#
modifier: MODEL1310110063#
product: MODEL1310110063#
is described by: ECO:0000212
is version of: http://identifiers.org/ec-code/2.6.1.19
is: SBO:0000176
type: Reaction
notes: GENE_ASSOCIATION: (18.1) or (18.2) SUBSYSTEM: beta-Alanine metabolism EC Number: 2.6.19.4 Confidence Level: 1 AUTHORS: PMID:15304357 NOTES:SAB

http://identifiers.org/biomodels.db/MODEL1310110063#_dd5f24b1_a016_48af_bd95_f9e1c95345b2
type: Species
initial amount: NaN
is: SBO:0000252
has only substance units: false
boundary condition: true
name: HSD17B4
initial concentration: NaN
constant: false
is: E9PB82
is encoded by: hsa:3295

metaM drib e
type: Species
is: SBO:0000247
is: HMDB03224
initial amount: NaN
is: CHEBI:28816
initial concentration: 1.0
boundary condition: false
constant: false
notes: FORMULA: C5H10O4 CHARGE: 0 INCHI: InChI=1S/C5H10O4/c6-2-1-4(8)5(9)3-7/h2,4-5,7-9H,1,3H2/t4-,5+/m0/s1 EHMN_ABBREVIATION: C01801
has only substance units: false
name: 2-deoxy-D-ribose

metaM retinol 9 cis c
notes: FORMULA: C20H30O CHARGE: 0 INCHI: InChI=1S/C20H30O/c1-16(8-6-9-17(2)13-15-21)11-12-19-18(3)10-7-14-20(19,4)5/h6,8-9,11-13,21H,7,10,14-15H2,1-5H3/b9-6+,12-11+,16-8+,17-13+
is: SBO:0000247
constant: false
name: 9-cis-retinol
initial amount: NaN
has only substance units: false
type: Species
initial concentration: 1.0
is: HMDB06217
boundary condition: false
is: CHEBI:17336

metaR RE3006M
reversible: true
modifier: MODEL1310110063#
is version of: http://identifiers.org/ec-code/4.2.1.17
is described by: ECO:0000000
reactant: MODEL1310110063#
fast: false
product: MODEL1310110063#
type: Reaction
is: SBO:0000176
name: RE3006
kinetic law: MODEL1310110063#
notes: GENE_ASSOCIATION: (10449.1) or (3032.1) or (3030.1) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.16 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:7775433 NOTES:
is version of: http://identifiers.org/ec-code/2.3.1.16

metaR BALABETAtc
kinetic law: MODEL1310110063#
product: MODEL1310110063#
reactant: MODEL1310110063#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of beta alanine into the intestinal cells by beta transport system
type: Reaction

metaM bildglcur c
is: CHEBI:58471
has only substance units: false
boundary condition: false
is: HMDB03325
initial amount: NaN
is: SBO:0000247
constant: false
initial concentration: 1.0
notes: FORMULA: C45H50N4O18 CHARGE: -2 INCHI: InChI=1S/C45H52N4O18/c1-7-20-19(6)40(58)49-27(20)14-25-18(5)23(10-12-31(51)65-45-37(57)33(53)35(55)39(67-45)43(62)63)29(47-25)15-28-22(17(4)24(46-28)13-26-16(3)21(8-2)41(59)48-26)9-11-30(50)64-44-36(56)32(52)34(54)38(66-44)42(60)61/h7-8,13-14,32-39,44-47,52-57H,1-2,9-12,15H2,3-6H3,(H,48,59)(H,49,58)(H,60,61)(H,62,63)/p-2/b26-13+,27-14+/t32-,33-,34-,35-,36+,37+,38-,39-,44+,45+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01616 EHMN_ABBREVIATION: C05787
type: Species
name: bis(beta-glucosyluronate)bilirubin

metaR CSPG Btly
reactant: MODEL1310110063#
kinetic law: MODEL1310110063#
fast: false
product: MODEL1310110063#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 2 AUTHORS: NOTES:
reversible: false
name: chondroitin sulfate B transport, extracellular to lysosome
is described by: ECO:0000000
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110063#_e91c6c92_ecfc_4391_bbb4_7d468c2a8eef
initial concentration: NaN
boundary condition: true
constant: false
type: Species
name: ADH5
is encoded by: hsa:128
is: SBO:0000252
has only substance units: false
is: Q6IRT1
initial amount: NaN

metaM ksii core2 pre3 g
has only substance units: false
is: CHEBI:58053
initial concentration: 1.0
is: SBO:0000247
constant: false
is: C00130
is: HMDB00175
initial amount: NaN
name: keratan sulfate II biosynthesis, precursor 3
boundary condition: false
notes: FORMULA: C47H76N4O33X CHARGE: -1
type: Species

metaR NACHEX8ly
notes: GENE_ASSOCIATION: (3073.1 and 3074.1) or (3074.1) or (3073.1) SUBSYSTEM: Chondroitin sulfate degradation EC Number: 3.2.1.52 Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12706724,PMID:8993162 NOTES:NCD
modifier: MODEL1310110063#
is: SBO:0000176
name: beta-N-acetylhexosaminidase, lysosomal
type: Reaction
reactant: MODEL1310110063#
fast: false
kinetic law: MODEL1310110063#
is described by: ECO:0000000
reversible: false
is version of: http://identifiers.org/ec-code/3.2.1.52
product: MODEL1310110063#

metaR r0051
type: Reaction
fast: false
kinetic law: MODEL1310110063#
is version of: http://identifiers.org/ec-code/3.1.3.5
notes: GENE_ASSOCIATION: (AI769281.1) or (30833.1) or (93034.1) or (22978.1) or (51251.1) or (4907.1) or (56953.1) or (57786.1) or (57665.1) SUBSYSTEM: Purine catabolism EC Number: 2.4.2.7 Confidence Level: 0 AUTHORS: PMID:6778226,PMID:692402 NOTES:
name: AMP:pyrophosphate phosphoribosyltransferase Purine metabolism EC:2.4.2.7
is: SBO:0000176
modifier: MODEL1310110063#
reactant: MODEL1310110063#
reversible: true
product: MODEL1310110063#
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110063#_277de637_7e28_499f_8e9d_aa25bf97dc75
boundary condition: true
has only substance units: false
constant: false
type: Species
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:U37519
name: _U37519_1_e
is: SBO:0000252

metaM prostgi2 r
type: Species
name: prostaglandin I2(1-)
constant: false
is: CHEBI:57403
initial amount: NaN
is: SBO:0000247
is: HMDB01335
has only substance units: false
notes: FORMULA: C20H31O5 CHARGE: -1 INCHI: InChI=1S/C20H32O5/c1-2-3-4-7-14(21)10-11-16-17-12-15(8-5-6-9-20(23)24)25-19(17)13-18(16)22/h8,10-11,14,16-19,21-22H,2-7,9,12-13H2,1H3,(H,23,24)/p-1/b11-10+,15-8-/t14-,16+,17+,18+,19-/m0/s1 EHMN_ABBREVIATION: C01312
initial concentration: 1.0
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110063#_3f256db0_2a4d_4776_bea1_48c5a1285f36
constant: false
is encoded by: hsa:4707
is: SBO:0000252
has only substance units: false
is: O75438
boundary condition: true
initial concentration: NaN
initial amount: NaN
type: Species
name: NDUFB1

http://identifiers.org/biomodels.db/MODEL1310110063#_44db7afa_d001_4265_9b32_795f0e39e8ca
is: O43916
name: CHST1
constant: false
initial concentration: NaN
is: SBO:0000252
type: Species
is encoded by: hsa:8534
initial amount: NaN
boundary condition: true
has only substance units: false

metaR EX CE5854 LPAREN e RPAREN
kinetic law: MODEL1310110063#
reactant: MODEL1310110063#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: gama-CEHC-glucuronide exchange
type: Reaction

metaM drib c
is: SBO:0000247
is: HMDB03224
initial concentration: 1.0
boundary condition: false
type: Species
initial amount: NaN
has only substance units: false
is: CHEBI:28816
notes: FORMULA: C5H10O4 CHARGE: 0 INCHI: InChI=1S/C5H10O4/c6-2-1-4(8)5(9)3-7/h2,4-5,7-9H,1,3H2/t4-,5+/m0/s1 EHMN_ABBREVIATION: C01801
constant: false
name: 2-deoxy-D-ribose

metaM adrncoa c
initial amount: NaN
is: SBO:0000247
is: http://identifiers.org/pubchem.compound/47205480
name: adrenyl coenzyme A
constant: false
notes: FORMULA: C43H66N7O17P3S CHARGE: -4 INCHI: InChI=1/C43H70N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-34(52)71-27-26-45-33(51)24-25-46-41(55)38(54)43(2,3)29-64-70(61,62)67-69(59,60)63-28-32-37(66-68(56,57)58)36(53)42(65-32)50-31-49-35-39(44)47-30-48-40(35)50/h8-9,11-12,14-15,17-18,30-32,36-38,42,53-54H,4-7,10,13,16,19-29H2,1-3H3,(H,45,51)(H,46,55)(H,59,60)(H,61,62)(H2,44,47,48)(H2,56,57,58)/b9-8-,12-11-,15-14-,18-17-/t32-,36-,37-,38?,42-/m1/s1
type: Species
initial concentration: 1.0
boundary condition: false
is: C16170
has only substance units: false

metaM thyox L e
boundary condition: false
name: L-thyroxine
has only substance units: false
notes: FORMULA: C15H11I4NO4 CHARGE: 0 INCHI: InChI=1S/C15H11I4NO4/c16-8-4-7(5-9(17)13(8)21)24-14-10(18)1-6(2-11(14)19)3-12(20)15(22)23/h1-2,4-5,12,21H,3,20H2,(H,22,23)/t12-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00849
is: SBO:0000247
initial amount: NaN
type: Species
initial concentration: 1.0
constant: false
is: CHEBI:18332
is: HMDB00248

metaR MI134P4P
type: Reaction
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Inositol phosphate metabolism EC Number: Confidence Level: 2 AUTHORS: PMID:2906139 NOTES:NCD
name: inositol-1,3,4-trisphosphate 4-phosphatase
kinetic law: MODEL1310110063#
reversible: false
is: SBO:0000176
reactant: MODEL1310110063#
is described by: ECO:0000000
product: MODEL1310110063#

metaR ALASERNaEx
notes: GENE_ASSOCIATION: (6509.1) or (6510.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14530974 NOTES:SAB see Kanai and Hediger 2004 (2003), PMID 14530974
is described by: ECO:0000269
reactant: MODEL1310110063#
name: L-alanine/L-serine Na-dependent exchange (Ala-L in)
reversible: false
is: SBO:0000185
type: Reaction
product: MODEL1310110063#
modifier: MODEL1310110063#
fast: false
kinetic law: MODEL1310110063#

metaR BAMPPALDOX
notes: GENE_ASSOCIATION: (8854.2) or (501.1) or (216.1) or (224.1) or (8854.3) or (223.1) or (8854.1) SUBSYSTEM: beta-Alanine metabolism EC Number: 1.2.1.36 Confidence Level: 1 AUTHORS: PMID:12586697 NOTES:SAB
is described by: ECO:0000212
is: SBO:0000176
type: Reaction
product: MODEL1310110063#
fast: false
name: beta-Aminopropion aldehyde:NAD+ oxidoreductase
reversible: false
is version of: http://identifiers.org/ec-code/1.2.1.3
is version of: http://identifiers.org/ec-code/1.2.1.36
reactant: MODEL1310110063#
kinetic law: MODEL1310110063#
modifier: MODEL1310110063#

http://identifiers.org/biomodels.db/MODEL1310110063#_cf3c6b33_546b_4ba9_9ce7_b82570c45307
constant: false
type: Species
is encoded by: hsa:56954
name: NIT2
has only substance units: false
initial amount: NaN
is: Q9NQR4
is: SBO:0000252
initial concentration: NaN
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110063#_1568833f_0607_4a7b_8476_fa106f89dba1
is: P00441
is encoded by: hsa:6647
name: SOD1
has only substance units: false
is: SBO:0000252
constant: false
initial amount: NaN
type: Species
initial concentration: NaN
boundary condition: true

metaM glyclt x
name: glycolate
is: SBO:0000247
initial amount: NaN
is: CHEBI:29805
notes: FORMULA: C2H3O3 CHARGE: -1 INCHI: InChI=1S/C2H4O3/c3-1-2(4)5/h3H,1H2,(H,4,5)/p-1 EHMN_ABBREVIATION: C00160
boundary condition: false
initial concentration: 1.0
is: HMDB00115
constant: false
has only substance units: false
type: Species

metaR RETI1
notes: GENE_ASSOCIATION: SUBSYSTEM: Vitamin A metabolism EC Number: 5.2.1.7 Confidence Level: 2 AUTHORS: PMID:1503811 NOTES:IT
fast: false
reactant: MODEL1310110063#
is described by: ECO:0000000
type: Reaction
reversible: true
is: SBO:0000176
name: retinol isomerase (11-cis)
product: MODEL1310110063#
kinetic law: MODEL1310110063#

metaR S6TASE2ly
notes: GENE_ASSOCIATION: (2799.1) SUBSYSTEM: Heparan sulfate degradation EC Number: 3.1.6.14 Confidence Level: 4 AUTHORS: PMID:3196333,PMID:3689314,PMID:3689315 NOTES:NCD
is version of: http://identifiers.org/ec-code/3.1.6.14
fast: false
reversible: true
modifier: MODEL1310110063#
is: SBO:0000176
is described by: ECO:0000000
product: MODEL1310110063#
type: Reaction
name: N-acetylglucosamine-6-sulfatase, lysosomal
kinetic law: MODEL1310110063#
reactant: MODEL1310110063#

metaR ACETONEt2m
reversible: true
name: acetone mitochondrial transport via proton symport
fast: false
notes: GENE_ASSOCIATION: (6566.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: NOTES:NCD
type: Reaction
is: SBO:0000185
product: MODEL1310110063#
is described by: ECO:0000000
modifier: MODEL1310110063#
kinetic law: MODEL1310110063#
reactant: MODEL1310110063#

metaM crn e
type: Species
name: L-Carnitine
is: C00318
notes: FORMULA: C7H15NO3 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00270 EHMN_ABBREVIATION: C00318
constant: false
is: CHEBI:16347
boundary condition: false
is: SBO:0000247
is: HMDB00062
initial concentration: 1.0
initial amount: NaN
has only substance units: false

metaM retinol 9 cis e
constant: false
boundary condition: false
notes: FORMULA: C20H30O CHARGE: 0 INCHI: InChI=1S/C20H30O/c1-16(8-6-9-17(2)13-15-21)11-12-19-18(3)10-7-14-20(19,4)5/h6,8-9,11-13,21H,7,10,14-15H2,1-5H3/b9-6+,12-11+,16-8+,17-13+
initial amount: NaN
is: SBO:0000247
type: Species
name: 9-cis-retinol
is: HMDB06217
is: CHEBI:17336
has only substance units: false
initial concentration: 1.0

metaR EX tchola LPAREN e RPAREN
kinetic law: MODEL1310110063#
reactant: MODEL1310110063#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Taurocholic acid exchange
type: Reaction

metaR EX 3thexddcoacrn
kinetic law: MODEL1310110063#
reactant: MODEL1310110063#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for 3-hydroxy trans7,10-hexadecadienoyl carnitine
type: Reaction

metaM 3tetd7ecoa c
initial concentration: 1.0
notes: FORMULA: C35H56N7O18P3S CHARGE: -4
type: Species
name: 3-hydroxy tetradecenoyl-7-coa
boundary condition: false
has only substance units: false
is: SBO:0000247
initial amount: NaN
constant: false
is: HMDB05066

http://identifiers.org/biomodels.db/MODEL1310110063#_a2a7fce7_709c_43a5_8e20_fac6e918519b
has only substance units: false
is encoded by: hsa:5335
constant: false
boundary condition: true
initial amount: NaN
is: Q9UFY1
initial concentration: NaN
name: PLCG1
is: SBO:0000252
type: Species

metaR EX ocdca LPAREN e RPAREN
kinetic law: MODEL1310110063#
reactant: MODEL1310110063#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: echange reaction for octadecanoate (n-C18:0)
type: Reaction

metaR DHCR71r
kinetic law: MODEL1310110063#
notes: GENE_ASSOCIATION: (1717.1) SUBSYSTEM: Cholesterol metabolism EC Number: 1.3.1.21 Confidence Level: 4 AUTHORS: PMID:9465114 NOTES:lanosterol -> cholesterol pathway see paper refs Moebius et al PNAS 95:1899-1902 - check/re-check lit for more specific details (NADPH known to be cofactor - also NADH?, possibly rev?) NJ
reactant: MODEL1310110063#
name: 7-dehydrocholesterol reductase
reversible: false
is version of: http://identifiers.org/ec-code/1.3.1.21
is: SBO:0000176
is described by: ECO:0000134
type: Reaction
modifier: MODEL1310110063#
fast: false
product: MODEL1310110063#

metaM dhor S c
constant: false
boundary condition: false
is: SBO:0000247
is: HMDB03349
has only substance units: false
is: CHEBI:30864
name: (S)-dihydroorotate
initial amount: NaN
initial concentration: 1.0
notes: FORMULA: C5H5N2O4 CHARGE: -1 INCHI: InChI=1S/C5H6N2O4/c8-3-1-2(4(9)10)6-5(11)7-3/h2H,1H2,(H,9,10)(H2,6,7,8,11)/p-1/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00285
type: Species

metaR EX spc hs LPAREN e RPAREN
kinetic law: MODEL1310110063#
reactant: MODEL1310110063#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: sphingosylphosphorylcholine (homo sapiens) exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110063#_592c724e_67df_4325_9ce3_06a65e4fbc8e
has only substance units: false
boundary condition: true
initial amount: NaN
is encoded by: hsa:2679
constant: false
name: GGT3P
is: SBO:0000252
initial concentration: NaN
type: Species

http://identifiers.org/biomodels.db/MODEL1310110063#_a5735232_8778_4824_941e_02bf71653f2b
is: Q9P212
is encoded by: hsa:51196
initial concentration: NaN
has only substance units: false
constant: false
initial amount: NaN
is: SBO:0000252
type: Species
boundary condition: true
name: PLCE1

http://identifiers.org/biomodels.db/MODEL1310110063#_38ef084b_d502_4c2a_a165_e2c7ec198781
is encoded by: hsa:8525
initial amount: NaN
initial concentration: NaN
constant: false
is: SBO:0000252
boundary condition: true
type: Species
is: B7Z6M3
has only substance units: false
name: DGKZ

http://identifiers.org/biomodels.db/MODEL1310110063#_c0559ff3_d5c0_4fb6_9f9a_bbc0b37e34fe
is: SBO:0000252
name: SLC25A6
initial amount: NaN
is encoded by: hsa:293
constant: false
type: Species
has only substance units: false
is: Q6I9V5
boundary condition: true
initial concentration: NaN

metaM nh4 m
is: C01342
initial concentration: 1.0
constant: false
is: SBO:0000247
has only substance units: false
boundary condition: false
is: HMDB00051
name: Ammonium
type: Species
is: CHEBI:28938
initial amount: NaN
notes: FORMULA: H4N CHARGE: 1 HEPATONET_1.0_ABBREVIATION: HC00765 EHMN_ABBREVIATION: C01342

http://identifiers.org/biomodels.db/MODEL1310110063#_d0267a97_5237_4027_8cab_eda8dd6b045f
name: GCNT4
initial concentration: NaN
initial amount: NaN
constant: false
type: Species
is: Q9P109
has only substance units: false
is encoded by: hsa:51301
is: SBO:0000252
boundary condition: true

metaR DGULND
kinetic law: MODEL1310110063#
is described by: ECO:0000000
product: MODEL1310110063#
type: Reaction
is: SBO:0000176
name: dehydro-L-gulonate decarboxylase
fast: false
reversible: true
reactant: MODEL1310110063#
notes: GENE_ASSOCIATION: SUBSYSTEM: Pentose phosphate pathway EC Number: 4.1.1.34 Confidence Level: 2 AUTHORS: PMID:6821187 NOTES:NCD

metaR DPMVDx
is: SBO:0000176
is version of: http://identifiers.org/ec-code/4.1.1.33
reactant: MODEL1310110063#
is described by: ECO:0000134
fast: false
type: Reaction
notes: GENE_ASSOCIATION: (4597.1) SUBSYSTEM: Cholesterol metabolism EC Number: 4.1.1.33 Confidence Level: 4 AUTHORS: PMID:8188698 NOTES:peroxisomal version - NJ
kinetic law: MODEL1310110063#
product: MODEL1310110063#
modifier: MODEL1310110063#
name: diphosphomevalonate decarboxylase
reversible: false

metaM octe5coa x
has only substance units: false
constant: false
initial concentration: 1.0
name: 5-octenoylcoa
type: Species
is: SBO:0000247
boundary condition: false
is: http://identifiers.org/pubchem.compound/16019966
initial amount: NaN
notes: FORMULA: C29H44N7O17P3S CHARGE: -4

metaR FAOXC101m
kinetic law: MODEL1310110063#
product: MODEL1310110063#
reactant: MODEL1310110063#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: isomerization(C10:1)m
type: Reaction

metaM hexdectecoa x
constant: false
name: 2,4,7,10-hexadecatetraenoylcoa
initial concentration: 1.0
notes: FORMULA: C37H54N7O17P3S CHARGE: -4
type: Species
has only substance units: false
is: SBO:0000247
boundary condition: false
initial amount: NaN
is: HMDB02288

http://identifiers.org/biomodels.db/MODEL1310110063#_c447017d_18cd_44b8_9d98_8884635504fe
name: ATP5G1
is: Q6FIH7
constant: false
initial amount: NaN
type: Species
is: SBO:0000252
is encoded by: hsa:516
boundary condition: true
initial concentration: NaN
has only substance units: false

metaR PAPStg
kinetic law: MODEL1310110063#
product: MODEL1310110063#
reversible: true
is: SBO:0000185
reactant: MODEL1310110063#
fast: false
is described by: ECO:0000269
modifier: MODEL1310110063#
name: 3'-Phosphoadenylyl sufate Golgi transport
type: Reaction
notes: GENE_ASSOCIATION: (347734.1) SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 4 AUTHORS: PMID:12716889 NOTES:NCD

metaR EX tetpent3 LPAREN e RPAREN
kinetic law: MODEL1310110063#
reactant: MODEL1310110063#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: tetracosapentaenoic acid, n-3 exchange
type: Reaction

metaR S2TASE3ly
is version of: http://identifiers.org/ec-code/3.1.6.13
reactant: MODEL1310110063#
name: iduronate-2-sulfatase, lysosomal
notes: GENE_ASSOCIATION: (3423.2) or (3423.1) SUBSYSTEM: Chondroitin sulfate degradation EC Number: 3.1.6.13 Confidence Level: 4 AUTHORS: PMID:2122463,PMID:8244397,PMID:8530090,PMID:8993162 NOTES:NCD
fast: false
product: MODEL1310110063#
is described by: ECO:0000000
type: Reaction
reversible: false
modifier: MODEL1310110063#
is: SBO:0000176
kinetic law: MODEL1310110063#

metaM clpnd e
notes: FORMULA: C22H33O2 CHARGE: -1 INCHI: InChI=1S/C22H34O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22(23)24/h3-4,6-7,9-10,12-13,15-16H,2,5,8,11,14,17-21H2,1H3,(H,23,24)/b4-3-,7-6-,10-9-,13-12-,16-15-
name: clupanodonic acid
has only substance units: false
initial concentration: 1.0
type: Species
is: SBO:0000247
initial amount: NaN
boundary condition: false
constant: false
is: HMDB06528
is: CHEBI:53488

http://identifiers.org/biomodels.db/MODEL1310110063#_cb4d025b_c311_4eb1_9b09_8e088573233b
is: SBO:0000297
name: ATP5A1:ATP5B:ATP5C1:ATP5D:ATP5E
constant: false
is encoded by: hsa:498
boundary condition: true
initial amount: NaN
initial concentration: NaN
type: Species
has only substance units: false
has part: B4DY56

metaR r0911
reversible: true
name: Facilitated diffusion
kinetic law: MODEL1310110063#
product: MODEL1310110063#
reactant: MODEL1310110063#
is: SBO:0000185
is described by: ECO:0000000
fast: false
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:11004451,PMID:8898903 NOTES:

metaR GLUDym
is version of: http://identifiers.org/ec-code/1.4.1.3
notes: GENE_ASSOCIATION: (2747.1) or (2746.1) SUBSYSTEM: Glutamate metabolism EC Number: 1.4.1.4 Confidence Level: 4 AUTHORS: PMID:12324473,PMID:3368458 NOTES:
reactant: MODEL1310110063#
fast: false
modifier: MODEL1310110063#
product: MODEL1310110063#
name: glutamate dehydrogenase (NADP), mitochondrial
kinetic law: MODEL1310110063#
type: Reaction
is described by: ECO:0000269
reversible: true
is: SBO:0000176

metaR MI1PP
fast: false
is: SBO:0000176
product: MODEL1310110063#
is version of: http://identifiers.org/ec-code/3.1.3.25
reactant: MODEL1310110063#
modifier: MODEL1310110063#
type: Reaction
reversible: false
kinetic law: MODEL1310110063#
is described by: ECO:0000269
name: myo-inositol 1-phosphatase
notes: GENE_ASSOCIATION: (3612.1) or (3613.1) SUBSYSTEM: Inositol phosphate metabolism EC Number: 3.1.3.25 Confidence Level: 4 AUTHORS: PMID:1377913,PMID:2906139,PMID:9322233 NOTES:JLR

metaM ksi deg11 l
initial concentration: 1.0
is: SBO:0000247
initial amount: NaN
name: keratan sulfate I, degradation product 11
constant: false
type: Species
notes: FORMULA: C180H289N12O158S9 CHARGE: -9
boundary condition: false
is: CHEBI:12936
is: HMDB00143
has only substance units: false

metaM ksi deg30 l
is: SBO:0000247
is: HMDB00143
boundary condition: false
name: keratan sulfate I, degradation product 30
notes: FORMULA: C90H147N6O75S3 CHARGE: -3
has only substance units: false
initial concentration: 1.0
constant: false
is: CHEBI:12936
initial amount: NaN
type: Species

metaM aicar c
is: SBO:0000247
notes: FORMULA: C9H13N4O8P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC01334 EHMN_ABBREVIATION: C04677
has only substance units: false
is: HMDB01517
initial concentration: 1.0
constant: false
name: 5-Amino-1-(5-Phospho-D-ribosyl)imidazole-4-carboxamide
boundary condition: false
is: C04677
is: CHEBI:58475
initial amount: NaN
type: Species

metaR RETI3
reactant: MODEL1310110063#
kinetic law: MODEL1310110063#
name: retinol isomerase (13-cis)
reversible: true
is described by: ECO:0000000
type: Reaction
product: MODEL1310110063#
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Vitamin A metabolism EC Number: 5.2.1.7 Confidence Level: 4 AUTHORS: PMID:11606944 NOTES:IT
fast: false

metaR ASCBt4
type: Reaction
is: SBO:0000185
reactant: MODEL1310110063#
notes: GENE_ASSOCIATION: (9962.2) or (9963.1) or (9962.1) or (9963.2) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10471399,PMID:10556483,PMID:10556521,PMID:10631088,PMID:15705056 NOTES:NCD
fast: false
reversible: true
name: L-ascorbate transport via proton symport
modifier: MODEL1310110063#
kinetic law: MODEL1310110063#
is described by: ECO:0000269
product: MODEL1310110063#

http://identifiers.org/biomodels.db/MODEL1310110063#_4a517c4a_a1ac_41c9_8dcf_403be7aabee4
initial amount: NaN
name: GLRX2
type: Species
is: Q9NS18
initial concentration: NaN
constant: false
has only substance units: false
is: SBO:0000252
boundary condition: true
is encoded by: hsa:51022

metaR ICDHy
modifier: MODEL1310110063#
reversible: false
reactant: MODEL1310110063#
fast: false
is version of: http://identifiers.org/ec-code/1.1.1.42
name: isocitrate dehydrogenase (NADP)
notes: GENE_ASSOCIATION: (3417.1) SUBSYSTEM: Citric acid cycle EC Number: 1.1.1.42 Confidence Level: 4 AUTHORS: PMID:10521434 NOTES:Two reactions (ICDH1 and ICDH2) for isocitrate dehydrogenase
type: Reaction
kinetic law: MODEL1310110063#
product: MODEL1310110063#
is described by: ECO:0000269
is: SBO:0000176

metaR S6TASE14ly
is: SBO:0000176
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (2799.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.1.6.14 Confidence Level: 4 AUTHORS: PMID:3196333,PMID:3689314,PMID:3689315 NOTES:NCD
product: MODEL1310110063#
is version of: http://identifiers.org/ec-code/3.1.6.14
type: Reaction
kinetic law: MODEL1310110063#
reversible: true
modifier: MODEL1310110063#
reactant: MODEL1310110063#
name: N-acetylglucosamine-6-sulfatase, lysosomal
fast: false

http://identifiers.org/biomodels.db/MODEL1310110063#_5696d248_b45e_41f2_bcf4_8292b6609ce5
is: SBO:0000252
has only substance units: false
is: Q02218
constant: false
boundary condition: true
type: Species
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:4967
name: OGDH

metaM nrvnccoa x
initial amount: NaN
constant: false
is: C16532
type: Species
boundary condition: false
notes: FORMULA: C45H76N7O17P3S CHARGE: -4 INCHI: InChI=1/C45H80N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-24-25-36(54)73-29-28-47-35(53)26-27-48-43(57)40(56)45(2,3)31-66-72(63,64)69-71(61,62)65-30-34-39(68-70(58,59)60)38(55)44(67-34)52-33-51-37-41(46)49-32-50-42(37)52/h11-12,32-34,38-40,44,55-56H,4-10,13-31H2,1-3H3,(H,47,53)(H,48,57)(H,61,62)(H,63,64)(H2,46,49,50)(H2,58,59,60)/b12-11-/t34-,38-,39-,40?,44-/m1/s1
has only substance units: false
initial concentration: 1.0
name: nervonyl coenzyme A
is: SBO:0000247

metaR HOCTDECCRNe
kinetic law: MODEL1310110063#
product: MODEL1310110063#
reactant: MODEL1310110063#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of 3-hydroxyoctadecanoyl carnitine into extra cellular space
type: Reaction

metaR RE3079X
name: RE3079
reactant: MODEL1310110063#
is: SBO:0000176
kinetic law: MODEL1310110063#
is version of: http://identifiers.org/ec-code/6.2.1.3
is described by: ECO:0000000
type: Reaction
modifier: MODEL1310110063#
notes: GENE_ASSOCIATION: (11001.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 0 AUTHORS: PMID:11356164 NOTES:IT - fixed proton
product: MODEL1310110063#
fast: false
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110063#_5c7e3cc6_b370_40c6_b9eb_802f83b13d08
has only substance units: false
name: ABAT
boundary condition: true
constant: false
is: SBO:0000252
is encoded by: hsa:18
initial amount: NaN
type: Species
initial concentration: NaN

metaR RETI2
product: MODEL1310110063#
fast: false
reversible: true
is described by: ECO:0000000
type: Reaction
reactant: MODEL1310110063#
kinetic law: MODEL1310110063#
is: SBO:0000176
name: retinol isomerase (9-cis)
notes: GENE_ASSOCIATION: SUBSYSTEM: Vitamin A metabolism EC Number: 5.2.1.7 Confidence Level: 2 AUTHORS: PMID:1503811 NOTES:IT

metaR CYSTA
is: SBO:0000176
reversible: true
fast: false
product: MODEL1310110063#
notes: GENE_ASSOCIATION: (2805.1) SUBSYSTEM: Methionine and cysteine metabolism EC Number: 2.6.1.3 Confidence Level: 2 AUTHORS: PMID:15189131,PMID:7113743 NOTES:MM
modifier: MODEL1310110063#
is version of: http://identifiers.org/ec-code/2.6.1.1
type: Reaction
reactant: MODEL1310110063#
name: cysteine transaminase
is described by: ECO:0000304
kinetic law: MODEL1310110063#

http://identifiers.org/biomodels.db/MODEL1310110063#_22f0a1e9_ef7b_42e6_be19_d6949a5b40ea
constant: false
is: SBO:0000252
boundary condition: true
name: NT5C2
initial amount: NaN
is encoded by: hsa:22978
type: Species
is: P49902
has only substance units: false
initial concentration: NaN

metaM retinal cis 9 c
constant: false
is: HMDB01358
boundary condition: false
is: CHEBI:17898
name: all-trans-retinal
notes: FORMULA: C20H28O CHARGE: 0 INCHI: InChI=1S/C20H28O/c1-16(8-6-9-17(2)13-15-21)11-12-19-18(3)10-7-14-20(19,4)5/h6,8-9,11-13,15H,7,10,14H2,1-5H3/b9-6+,12-11+,16-8+,17-13+ EHMN_ABBREVIATION: CE5575
initial amount: NaN
has only substance units: false
initial concentration: 1.0
type: Species
is: SBO:0000247

metaR 3SALATAim
notes: GENE_ASSOCIATION: (2806.1) SUBSYSTEM: Methionine and cysteine metabolism EC Number: 2.6.1.1 Confidence Level: 2 AUTHORS: PMID:3346220 NOTES:MM. activity measured in rat, 3-sulfinoalanine is substrate found in human brain
kinetic law: MODEL1310110063#
type: Reaction
reversible: false
product: MODEL1310110063#
is described by: ECO:0000304
fast: false
modifier: MODEL1310110063#
reactant: MODEL1310110063#
is version of: http://identifiers.org/ec-code/2.6.1.1
is: SBO:0000176
name: 3-sulfino-alanine transaminase (irreversible), mitochondrial

metaR r2202
modifier: MODEL1310110063#
reversible: true
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.5
type: Reaction
product: MODEL1310110063#
fast: false
reactant: MODEL1310110063#
kinetic law: MODEL1310110063#
is described by: ECO:0000000
is: SBO:0000185
notes: GENE_ASSOCIATION: (6566.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:

metaR GLYCLTtp
is described by: ECO:0000000
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: PMID:15240345 NOTES:NCD
type: Reaction
product: MODEL1310110063#
is: SBO:0000185
reversible: false
name: glycolate transport into peroxisome
kinetic law: MODEL1310110063#
reactant: MODEL1310110063#

metaR GTHO
is: SBO:0000176
product: MODEL1310110063#
fast: false
reversible: false
notes: GENE_ASSOCIATION: (2936.1) SUBSYSTEM: Glutamate metabolism EC Number: 1.8.1.7 Confidence Level: 2 AUTHORS: PMID:10708558 NOTES:NCD, TV This EC (1.6.4.2) is obsolete. The new EC is 1.8.1.7. http://www.genome.ad.jp/dbget-bin/www_bget?ec:1.6.4.2
kinetic law: MODEL1310110063#
reactant: MODEL1310110063#
name: glutathione oxidoreductase
type: Reaction
is described by: ECO:0000254
is version of: http://identifiers.org/ec-code/1.8.1.7
modifier: MODEL1310110063#

metaR MDHm
name: malate dehydrogenase, mitochondrial
reversible: true
product: MODEL1310110063#
kinetic law: MODEL1310110063#
fast: false
notes: GENE_ASSOCIATION: (4191.1) SUBSYSTEM: Citric acid cycle EC Number: 1.1.1.37 Confidence Level: 0 AUTHORS: PMID:15565635,PMID:9933076 NOTES:IF. Biochemical
reactant: MODEL1310110063#
modifier: MODEL1310110063#
is version of: http://identifiers.org/ec-code/1.1.1.37
is described by: ECO:0000134
type: Reaction
is: SBO:0000176

metaR DM atp c
type: Reaction
is described by: ECO:0000134
name: DM_atp(c)
reactant: MODEL1310110063#
is: SBO:0000176
reversible: false
product: MODEL1310110063#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: AUTHORS: NOTES:
kinetic law: MODEL1310110063#
fast: false

metaR ABTArm
reactant: MODEL1310110063#
name: 4-aminobutyrate transaminase, reversible (mitochondrial)
kinetic law: MODEL1310110063#
modifier: MODEL1310110063#
fast: false
type: Reaction
is: SBO:0000176
notes: GENE_ASSOCIATION: (18.1) or (18.2) SUBSYSTEM: Glutamate metabolism EC Number: 2.6.19.4 Confidence Level: 4 AUTHORS: PMID:10407778,PMID:7721088 NOTES:kh 1/6/03
reversible: true
is version of: http://identifiers.org/ec-code/2.6.1.19
is described by: ECO:0000269
product: MODEL1310110063#

metaR EX cspg a LPAREN e RPAREN
kinetic law: MODEL1310110063#
reactant: MODEL1310110063#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: chondroitin sulfate A (GalNAc4S-GlcA) proteoglycan exchange
type: Reaction

metaR C162ACBP
kinetic law: MODEL1310110063#
product: MODEL1310110063#
reactant: MODEL1310110063#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: transport of 3-hydroxy trans7,10-hexadecadienoylcoa from mitochondria into cytosol
type: Reaction

metaM fadh2 x
name: FADH2(2-)
type: Species
initial amount: NaN
notes: FORMULA: C27H33N9O15P2 CHARGE: -2 INCHI: InChI=1S/C27H35N9O15P2/c1-10-3-12-13(4-11(10)2)35(24-18(32-12)25(42)34-27(43)33-24)5-14(37)19(39)15(38)6-48-52(44,45)51-53(46,47)49-7-16-20(40)21(41)26(50-16)36-9-31-17-22(28)29-8-30-23(17)36/h3-4,8-9,14-16,19-21,26,32,37-41H,5-7H2,1-2H3,(H,44,45)(H,46,47)(H2,28,29,30)(H2,33,34,42,43)/p-2/t14-,15+,16+,19-,20+,21+,26+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00770 EHMN_ABBREVIATION: C01352
initial concentration: 1.0
boundary condition: false
is: CHEBI:58307
has only substance units: false
constant: false
is: HMDB01197
is: SBO:0000247

metaR GTHP
reversible: true
name: glutathione peroxidase
type: Reaction
product: MODEL1310110063#
fast: false
is described by: ECO:0000134
kinetic law: MODEL1310110063#
reactant: MODEL1310110063#
is version of: http://identifiers.org/ec-code/1.11.1.9
is version of: http://identifiers.org/ec-code/1.11.1.15
is: SBO:0000176
modifier: MODEL1310110063#
is version of: http://identifiers.org/ec-code/1.11.1.12
notes: GENE_ASSOCIATION: (7001.3) or (5052.3) or (2877.1) or (2876.2) or (5052.2) or (2876.1) or (5052.1) or (7001.1) or (2879.1) or (7001.2) SUBSYSTEM: Glutathione metabolism EC Number: 1.11.1.9 Confidence Level: 4 AUTHORS: PMID:15802613,PMID:17015272,PMID:17015273 NOTES:NCD

http://identifiers.org/biomodels.db/MODEL1310110063#_fa959284_4bc8_4003_a980_d6a4866b633c
is: SBO:0000252
has only substance units: false
initial amount: NaN
initial concentration: NaN
constant: false
name: ADCY9
is: O60503
is encoded by: hsa:115
type: Species
boundary condition: true

metaM 6thf e
boundary condition: false
is: SBO:0000247
type: Species
constant: false
initial amount: NaN
notes: FORMULA: C44H51N12O21 CHARGE: -7 INCHI: InChI=1/C44H54N12O21/c45-21(36(66)67)5-10-26(57)43(15-30(61)62,27(58)11-6-22(46)37(68)69)44(28(59)12-7-23(47)38(70)71,41(76)77-31(63)14-9-25(49)40(74)75)56(29(60)13-8-24(48)39(72)73)35(65)18-1-3-19(4-2-18)51-16-20-17-52-33-32(53-20)34(64)55-42(50)54-33/h1-4,17,21-25,51H,5-16,45-49H2,(H,61,62)(H,66,67)(H,68,69)(H,70,71)(H,72,73)(H,74,75)(H3,50,52,54,55,64)/p-1/t21u,22u,23u,24u,25u,43u,44-/m1/s1
is: http://identifiers.org/pubchem.compound/169691
has only substance units: false
initial concentration: 1.0
name: hexaglutamyl folate (THF)

metaR r2201
reactant: MODEL1310110063#
is: SBO:0000185
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.5
type: Reaction
notes: GENE_ASSOCIATION: (6566.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
product: MODEL1310110063#
modifier: MODEL1310110063#
reversible: true
is described by: ECO:0000000
kinetic law: MODEL1310110063#
fast: false

metaM ksi deg3 l
is: SBO:0000247
initial concentration: 1.0
constant: false
name: keratan sulfate I, degradation product 3
has only substance units: false
is: CHEBI:30825
initial amount: NaN
notes: FORMULA: C233H371N16O205S12 CHARGE: -13
boundary condition: false
type: Species
is: HMDB00573

metaM for c
is: C00058
constant: false
has only substance units: false
is: SBO:0000247
initial concentration: 1.0
initial amount: NaN
is: CHEBI:15740
boundary condition: false
name: Formate
notes: FORMULA: CH1O2 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00061 EHMN_ABBREVIATION: C00058
type: Species
is: HMDB00142

http://identifiers.org/biomodels.db/MODEL1310110063#_0bf75474_7b98_4608_938c_1b37fce302f8
boundary condition: true
is encoded by: hsa:D29675
constant: false
type: Species
initial amount: NaN
initial concentration: NaN
name: _D29675_1_c
has only substance units: false
is: SBO:0000252

metaR MMSAD3m
modifier: MODEL1310110063#
fast: false
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/1.2.1.27
kinetic law: MODEL1310110063#
reversible: false
reactant: MODEL1310110063#
product: MODEL1310110063#
type: Reaction
notes: GENE_ASSOCIATION: (4329.1) SUBSYSTEM: Propanoate metabolism EC Number: 1.2.1.27 Confidence Level: 4 AUTHORS: PMID:10947204,PMID:1527093,PMID:6418146 NOTES:also EC 1.2.1.18 - NCD
name: methylmalonate-semialdehyde dehydrogenase (malonic semialdehyde), mitochondrial
is: SBO:0000176

metaR ACACT7p
name: acetyl-CoA acyltransferase (tetradecanoyl-CoA), peroxisomal
is described by: ECO:0000269
product: MODEL1310110063#
reactant: MODEL1310110063#
type: Reaction
reversible: false
modifier: MODEL1310110063#
fast: false
is version of: http://identifiers.org/ec-code/2.3.1.16
is: SBO:0000176
notes: GENE_ASSOCIATION: (30.1) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.16 Confidence Level: 4 AUTHORS: PMID:1679347 NOTES:NCD
kinetic law: MODEL1310110063#

metaR EX HC00229 LPAREN e RPAREN
kinetic law: MODEL1310110063#
reactant: MODEL1310110063#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of Isomaltose
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110063#_44298738_7e3d_4416_b896_9e844e0ae262
has only substance units: false
boundary condition: true
constant: false
type: Species
is encoded by: hsa:23517
name: SKIV2L2
initial concentration: NaN
initial amount: NaN
is: Q3MHC9
is: SBO:0000252

metaR EX cyan LPAREN e RPAREN
kinetic law: MODEL1310110063#
reactant: MODEL1310110063#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Hydrogen cyanide exchange
type: Reaction

metaM mmcoa S m
type: Species
name: (S)-methylmalonyl-CoA(5-)
is: HMDB02310
is: SBO:0000247
has only substance units: false
notes: FORMULA: C25H35N7O19P3S CHARGE: -5 INCHI: InChI=1S/C25H40N7O19P3S/c1-12(23(37)38)24(39)55-7-6-27-14(33)4-5-28-21(36)18(35)25(2,3)9-48-54(45,46)51-53(43,44)47-8-13-17(50-52(40,41)42)16(34)22(49-13)32-11-31-15-19(26)29-10-30-20(15)32/h10-13,16-18,22,34-35H,4-9H2,1-3H3,(H,27,33)(H,28,36)(H,37,38)(H,43,44)(H,45,46)(H2,26,29,30)(H2,40,41,42)/p-5/t12-,13+,16+,17+,18-,22+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00495
boundary condition: false
constant: false
is: CHEBI:57327
initial amount: NaN
initial concentration: 1.0

metaR RE2349C
is version of: http://identifiers.org/ec-code/2.6.1.64
is described by: ECO:0000000
modifier: MODEL1310110063#
product: MODEL1310110063#
kinetic law: MODEL1310110063#
fast: false
type: Reaction
reactant: MODEL1310110063#
notes: GENE_ASSOCIATION: (883.1) SUBSYSTEM: Tryptophan metabolism EC Number: 2.6.1.7 Confidence Level: 0 AUTHORS: PMID:10559215,PMID:8908429 NOTES:IT - removed H[c] on right hand side even though no charged formula for Kegg compound but same as reaction RE1233C
reversible: true
is: SBO:0000176
name: RE2349

metaR MI1PS
modifier: MODEL1310110063#
kinetic law: MODEL1310110063#
fast: false
reactant: MODEL1310110063#
product: MODEL1310110063#
is: SBO:0000176
name: myo-Inositol-1-phosphate synthase
reversible: false
notes: GENE_ASSOCIATION: (51477.1) SUBSYSTEM: Inositol phosphate metabolism EC Number: 5.5.1.4 Confidence Level: 4 AUTHORS: PMID:12941308 NOTES:NCD
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/5.5.1.4
type: Reaction

metaM txa2 r
is: HMDB01452
boundary condition: false
initial concentration: 1.0
initial amount: NaN
constant: false
notes: FORMULA: C20H31O5 CHARGE: -1 INCHI: InChI=1S/C20H32O5/c1-2-3-6-9-15(21)12-13-17-16(18-14-20(24-17)25-18)10-7-4-5-8-11-19(22)23/h4,7,12-13,15-18,20-21H,2-3,5-6,8-11,14H2,1H3,(H,22,23)/p-1/b7-4-,13-12+/t15-,16+,17+,18-,20+/m0/s1 EHMN_ABBREVIATION: C02198
type: Species
is: CHEBI:57445
has only substance units: false
name: thromboxane A2(1-)
is: SBO:0000247

metaR RE2814R
fast: false
type: Reaction
is: SBO:0000176
kinetic law: MODEL1310110063#
name: RE2814
notes: GENE_ASSOCIATION: SUBSYSTEM: Bile acid synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:0 NOTES:
reversible: true
is described by: ECO:0000000
reactant: MODEL1310110063#
product: MODEL1310110063#

metaM lys L c
is: HMDB00182
initial concentration: 1.0
constant: false
boundary condition: false
is: SBO:0000247
name: L-lysinium(1+)
has only substance units: false
initial amount: NaN
notes: FORMULA: C6H15N2O2 CHARGE: 1 INCHI: InChI=1S/C6H14N2O2/c7-4-2-1-3-5(8)6(9)10/h5H,1-4,7-8H2,(H,9,10)/p+1/t5-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00053 EHMN_ABBREVIATION: C00047
type: Species
is: CHEBI:32551

metaM ksi pre15 g
is: CHEBI:58053
initial concentration: 1.0
constant: false
notes: FORMULA: C149H240N10O119S4X CHARGE: -5
has only substance units: false
initial amount: NaN
is: C00130
type: Species
boundary condition: false
is: HMDB00175
is: SBO:0000247
name: keratan sulfate I biosynthesis, precursor 15

metaM hexdectecoa m
initial concentration: 1.0
name: 2,4,7,10-hexadecatetraenoylcoa
boundary condition: false
type: Species
constant: false
initial amount: NaN
notes: FORMULA: C37H54N7O17P3S CHARGE: -4
is: SBO:0000247
is: HMDB02288
has only substance units: false

metaR G14T2g
name: beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase, Golgi
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/2.4.1.22
kinetic law: MODEL1310110063#
is version of: http://identifiers.org/ec-code/2.4.1.90
modifier: MODEL1310110063#
is version of: http://identifiers.org/ec-code/2.4.1.38
reversible: false
fast: false
reactant: MODEL1310110063#
product: MODEL1310110063#
is: SBO:0000176
type: Reaction
notes: GENE_ASSOCIATION: (8703.1) or (2683.1) or (8704.2) or (8704.1) or (9334.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.38 Confidence Level: 4 AUTHORS: PMID:12512857,PMID:1903938,PMID:3094506,PMID:3144273,PMID:9405390,PMID:9435216 NOTES:Keratan sulfate II biosynthesis NCD

metaM idour l
is: HMDB02704
initial amount: NaN
constant: false
is: SBO:0000247
name: L-iduronate
has only substance units: false
type: Species
notes: FORMULA: C6H9O7 CHARGE: -1 INCHI: InChI=1S/C6H10O7/c7-1-2(8)3(9)4(10)5(11)6(12)13/h1-5,8-11H,(H,12,13)/p-1/t2-,3+,4-,5+/m0/s1
is: CHEBI:21338
boundary condition: false
initial concentration: 1.0

metaR ACNAMlt
reversible: true
is: SBO:0000185
modifier: MODEL1310110063#
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (26503.1) SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 4 AUTHORS: PMID:10581036,PMID:2768261 NOTES:H symport into lysososome. See PMID: 2768261 and PMID: 10581036 ( for human evidence). Sialic acid storage disorders (due to transporter mutations) require import and export e.g. PMID: 2768266 NJ
type: Reaction
product: MODEL1310110063#
reactant: MODEL1310110063#
name: N-acetylneuraminate transport into lysososme
fast: false
kinetic law: MODEL1310110063#

http://identifiers.org/biomodels.db/MODEL1310110063#_49fc21c0_4345_4d54_8efb_5fd859a4e4f9
is: B7Z2T0
is encoded by: hsa:478
constant: false
initial concentration: NaN
boundary condition: true
is: SBO:0000252
initial amount: NaN
type: Species
name: ATP1A3
has only substance units: false

metaR F6Tg
type: Reaction
kinetic law: MODEL1310110063#
product: MODEL1310110063#
is version of: http://identifiers.org/ec-code/2.4.1.68
fast: false
notes: GENE_ASSOCIATION: (2530.4) or (2530.1) or (2530.3) or (2530.2) or (2530.5) SUBSYSTEM: N-glycan synthesis EC Number: 2.4.1.68 Confidence Level: 0 AUTHORS: PMID:14514715 NOTES:NCD
is: SBO:0000176
reversible: false
reactant: MODEL1310110063#
modifier: MODEL1310110063#
name: glycoprotein 6-alpha-L-fucosyltransferase
is described by: ECO:0000000

metaR ALASm
reactant: MODEL1310110063#
reversible: false
kinetic law: MODEL1310110063#
notes: GENE_ASSOCIATION: (212.1) or (23464.1) or (211.2) or (211.1) SUBSYSTEM: Glycine, serine, alanine and threonine metabolism EC Number: 2.3.1.37 Confidence Level: 2 AUTHORS: PMID:2263504 NOTES:NCD
is described by: ECO:0000254
is: SBO:0000176
name: 5-aminolevulinate synthase
product: MODEL1310110063#
modifier: MODEL1310110063#
fast: false
is version of: http://identifiers.org/ec-code/2.3.1.37
is version of: http://identifiers.org/ec-code/2.3.1.29
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110063#_37546bad_5760_4d64_aafa_3f273ecb644a
name: PDE9A
initial amount: NaN
is encoded by: hsa:5152
initial concentration: NaN
boundary condition: true
type: Species
constant: false
is: SBO:0000252
has only substance units: false

metaR PTCRTD
name: diffusion of putriscine into the endothelial cells
product: MODEL1310110063#
is described by: ECO:0000134
kinetic law: MODEL1310110063#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID: 9505881, PMID: 11564949 NOTES:putriscine uptake by the cells via passive diffusion, reported to be more rapid at the basolateral side.
fast: false
reversible: true
type: Reaction
is: SBO:0000185
reactant: MODEL1310110063#

metaM mi134p c
is: CHEBI:58414
initial concentration: 1.0
type: Species
is: HMDB01143
initial amount: NaN
is: SBO:0000247
has only substance units: false
constant: false
boundary condition: false
name: 1D-myo-inositol 1,3,4-trisphosphate(6-)
notes: FORMULA: C6H9O15P3 CHARGE: -6 INCHI: InChI=1S/C6H15O15P3/c7-1-2(8)5(20-23(13,14)15)6(21-24(16,17)18)3(9)4(1)19-22(10,11)12/h1-9H,(H2,10,11,12)(H2,13,14,15)(H2,16,17,18)/p-6/t1-,2-,3+,4+,5+,6+/m1/s1 EHMN_ABBREVIATION: C01243

http://identifiers.org/biomodels.db/MODEL1310110063#_c2b0500e_317f_4702_b06d_dc95b8c5f23e
initial concentration: NaN
name: SULT1A1
boundary condition: true
initial amount: NaN
is: P50225
constant: false
has only substance units: false
type: Species
is: SBO:0000252
is encoded by: hsa:6817

metaR DHCR243r
is: SBO:0000176
notes: GENE_ASSOCIATION: (1718.1) SUBSYSTEM: Cholesterol metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:17984220,PMID:19520779,PMID:19520780 NOTES:lanosterol -> cholesterol pathway FAD known to be cofactor, other details missing NJ
is described by: ECO:0000134
type: Reaction
product: MODEL1310110063#
modifier: MODEL1310110063#
reactant: MODEL1310110063#
reversible: false
fast: false
kinetic law: MODEL1310110063#
name: 24-dehydrocholesterol reductase [Precursor]
is version of: http://identifiers.org/ec-code/1.3.1.72

metaR r0381
product: MODEL1310110063#
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Taurine and hypotaurine metabolism EC Number: 1.8.1.3 Confidence Level: 0 AUTHORS: PMID:13979247,PMID:16680556,PMID:7295801 NOTES:
kinetic law: MODEL1310110063#
reactant: MODEL1310110063#
fast: false
type: Reaction
is described by: ECO:0000000
is: SBO:0000176
name: hypotaurine:NAD+ oxidoreductase Taurine and hypotaurine metabolism EC:1.8.1.3

metaM for e
initial amount: NaN
boundary condition: false
type: Species
is: HMDB00142
initial concentration: 1.0
is: SBO:0000247
constant: false
notes: FORMULA: CH1O2 CHARGE: -1 INCHI: InChI=1S/CH2O2/c2-1-3/h1H,(H,2,3)/p-1 HEPATONET_1.0_ABBREVIATION: HC00061 EHMN_ABBREVIATION: C00058
has only substance units: false
is: CHEBI:15740
name: formate

metaR FAS120COA
is version of: http://identifiers.org/ec-code/2.3.1.85
notes: GENE_ASSOCIATION: (2194.1) SUBSYSTEM: Fatty acid synthesis EC Number: 2.3.1.86 Confidence Level: 4 AUTHORS: PMID:11756679,PMID:15507492 NOTES:NCD
reversible: false
fast: false
modifier: MODEL1310110063#
kinetic law: MODEL1310110063#
is described by: ECO:0000269
name: fatty-acyl-CoA synthase (n-C12:0CoA)
type: Reaction
product: MODEL1310110063#
is: SBO:0000176
reactant: MODEL1310110063#

metaR NACHEX25ly
fast: false
is: SBO:0000176
is described by: ECO:0000000
reversible: false
type: Reaction
modifier: MODEL1310110063#
is version of: http://identifiers.org/ec-code/3.2.1.52
notes: GENE_ASSOCIATION: (3073.1 and 3074.1) or (3073.1) or (3074.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.52 Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12706724,PMID:8993162 NOTES:NCD
name: beta-N-acetylhexosaminidase, lysosomal
kinetic law: MODEL1310110063#
reactant: MODEL1310110063#
product: MODEL1310110063#

metaR EX rib D LPAREN e RPAREN
kinetic law: MODEL1310110063#
reactant: MODEL1310110063#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for ribose
type: Reaction

metaM fadh2 r
notes: FORMULA: C27H33N9O15P2 CHARGE: -2 INCHI: InChI=1S/C27H35N9O15P2/c1-10-3-12-13(4-11(10)2)35(24-18(32-12)25(42)34-27(43)33-24)5-14(37)19(39)15(38)6-48-52(44,45)51-53(46,47)49-7-16-20(40)21(41)26(50-16)36-9-31-17-22(28)29-8-30-23(17)36/h3-4,8-9,14-16,19-21,26,32,37-41H,5-7H2,1-2H3,(H,44,45)(H,46,47)(H2,28,29,30)(H2,33,34,42,43)/p-2/t14-,15+,16+,19-,20+,21+,26+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00770 EHMN_ABBREVIATION: C01352
boundary condition: false
initial concentration: 1.0
type: Species
has only substance units: false
is: CHEBI:58307
initial amount: NaN
name: FADH2(2-)
is: SBO:0000247
is: HMDB01197
constant: false

metaR FACOAL224
fast: false
kinetic law: MODEL1310110063#
reactant: MODEL1310110063#
modifier: MODEL1310110063#
is: SBO:0000176
name: fatty-acid--CoA ligase
notes: GENE_ASSOCIATION: (2180.1) SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 4 AUTHORS: PMID:15292367 NOTES:NJ
is version of: http://identifiers.org/ec-code/6.2.1.3
product: MODEL1310110063#
type: Reaction
is described by: ECO:0000000
reversible: true

metaR DM pmtcoa LPAREN r RPAREN
kinetic law: MODEL1310110063#
reactant: MODEL1310110063#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 0 AUTHORS: PMID: 17173541 NOTES:added during gap-filling, no evidence for such a reaction. only assumed.
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: demand reaction for pmtcoa
type: Reaction

metaR 4NPHSFte
product: MODEL1310110063#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:9344226 NOTES:unknown mechanism, related cyp P450 metabolism reactions NJ. Biochemical, Rat
is: SBO:0000185
reversible: true
kinetic law: MODEL1310110063#
type: Reaction
name: xenobiotic transport
reactant: MODEL1310110063#
fast: false

metaM 3dodtricoa x
is: HMDB11123
name: 3,6,9-dodecatrienoylcoa
constant: false
boundary condition: false
is: SBO:0000247
type: Species
notes: FORMULA: C33H48N7O17P3S CHARGE: -4
is: C05279
initial amount: NaN
has only substance units: false
initial concentration: 1.0

metaR MTHFDm
kinetic law: MODEL1310110063#
fast: false
name: methylenetetrahydrofolate dehydrogenase (NADP), mitochondrial
is version of: http://identifiers.org/ec-code/3.5.4.9
is described by: ECO:0000269
reactant: MODEL1310110063#
is: SBO:0000176
modifier: MODEL1310110063#
is version of: http://identifiers.org/ec-code/6.3.4.3
reversible: true
product: MODEL1310110063#
type: Reaction
notes: GENE_ASSOCIATION: (25902.1) or (10797.1) SUBSYSTEM: Folate metabolism EC Number: 1.5.1.5 Confidence Level: 4 AUTHORS: PMID:12937168,PMID:8218174 NOTES:NCD

metaR RE1526M
is version of: http://identifiers.org/ec-code/4.2.1.107
product: MODEL1310110063#
is version of: http://identifiers.org/ec-code/1.1.1.35
reversible: true
is: SBO:0000176
reactant: MODEL1310110063#
name: RE1526
type: Reaction
fast: false
modifier: MODEL1310110063#
notes: GENE_ASSOCIATION: (3295.1) or (1962.1) or (3033.1) or (3028.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.1.1.35 Confidence Level: 0 AUTHORS: PMID:11451959 NOTES:
kinetic law: MODEL1310110063#
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110063#_232ec4ab_39b4_4fdd_bf0c_dca31cf1437a
boundary condition: true
initial concentration: NaN
is: Q16836
has only substance units: false
name: HADH
constant: false
initial amount: NaN
is: SBO:0000252
is encoded by: hsa:3033
type: Species

http://identifiers.org/biomodels.db/MODEL1310110063#_90932b7b_7fe0_4881_a8fe_32cccd6a0f96
has only substance units: false
is encoded by: hsa:1374
boundary condition: true
initial amount: NaN
constant: false
name: CPT1A
type: Species
is: SBO:0000252
is: Q8WZ48
initial concentration: NaN

metaR FMNAT
reactant: MODEL1310110063#
is version of: http://identifiers.org/ec-code/2.7.7.2
notes: GENE_ASSOCIATION: (80308.1) or (80308.2) SUBSYSTEM: Vitamin B2 metabolism EC Number: 2.7.7.2 Confidence Level: 2 AUTHORS: PMID:16643857,PMID:17049878 NOTES:Human Y/N: Y
kinetic law: MODEL1310110063#
product: MODEL1310110063#
fast: false
modifier: MODEL1310110063#
is described by: ECO:0000134
type: Reaction
name: FMN adenylyltransferase
reversible: false
is: SBO:0000176

metaR r1862
is: SBO:0000185
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
type: Reaction
is described by: ECO:0000000
modifier: MODEL1310110063#
reversible: false
fast: false
product: MODEL1310110063#
reactant: MODEL1310110063#
name: Y+LAT2 Utilized transport
kinetic law: MODEL1310110063#

http://identifiers.org/biomodels.db/MODEL1310110063#_2e1fc169_a1c3_4778_b644_2a9c4f0cc7ef
is encoded by: hsa:4249
is: Q09328
constant: false
name: MGAT5
is: SBO:0000252
type: Species
initial concentration: NaN
initial amount: NaN
boundary condition: true
has only substance units: false

metaR CREATt4 2 r
type: Reaction
is described by: ECO:0000269
fast: false
modifier: MODEL1310110063#
product: MODEL1310110063#
kinetic law: MODEL1310110063#
name: Creatine transport (sodium symport) (2:1)
reactant: MODEL1310110063#
is: SBO:0000185
reversible: true
notes: GENE_ASSOCIATION: (6535.1) or (386757.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12719981 NOTES:SAB

http://identifiers.org/biomodels.db/MODEL1310110063#_b75b051d_1789_460a_bf4b_52942d4547dc
boundary condition: true
is encoded by: hsa:10195
constant: false
initial concentration: NaN
has only substance units: false
name: ALG3
type: Species
is: SBO:0000252
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110063#_47eef27c_7ea9_4da0_99df_1c8860a43980
type: Species
boundary condition: true
initial concentration: NaN
is: Q96Q11
name: TRNT1
constant: false
initial amount: NaN
has only substance units: false
is: SBO:0000252
is encoded by: hsa:51095

http://identifiers.org/biomodels.db/MODEL1310110063#_d135cfe6_98ae_4d41_9bc9_aee1d52f60d4
constant: false
boundary condition: true
type: Species
initial amount: NaN
name: AK2
initial concentration: NaN
has only substance units: false
is: SBO:0000252
is encoded by: hsa:204

metaR EX 3tdcrn
kinetic law: MODEL1310110063#
reactant: MODEL1310110063#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for 3-hydroxy-tetradecanoyl carnitine
type: Reaction

metaR S6TASE17ly
is version of: http://identifiers.org/ec-code/3.1.6.14
reactant: MODEL1310110063#
notes: GENE_ASSOCIATION: (2799.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.1.6.14 Confidence Level: 4 AUTHORS: PMID:3196333,PMID:3689314,PMID:3689315 NOTES:NCD
kinetic law: MODEL1310110063#
is described by: ECO:0000000
name: N-acetylglucosamine-6-sulfatase, lysosomal
fast: false
is: SBO:0000176
type: Reaction
modifier: MODEL1310110063#
reversible: true
product: MODEL1310110063#

metaR r1861
modifier: MODEL1310110063#
name: Y+LAT2 Utilized transport
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reversible: false
fast: false
product: MODEL1310110063#
reactant: MODEL1310110063#
kinetic law: MODEL1310110063#
is: SBO:0000185
type: Reaction
is described by: ECO:0000000

metaM f1a l
name: F1alpha
is: CHEBI:17151
boundary condition: false
has only substance units: false
initial amount: NaN
constant: false
type: Species
is: HMDB02917
notes: FORMULA: C22H37N2O15X CHARGE: 0
initial concentration: 1.0
is: SBO:0000247

metaR NACHEX14ly
fast: false
kinetic law: MODEL1310110063#
is: SBO:0000176
name: beta-N-acetylhexosaminidase, lysosomal
is described by: ECO:0000000
reactant: MODEL1310110063#
modifier: MODEL1310110063#
is version of: http://identifiers.org/ec-code/3.2.1.52
product: MODEL1310110063#
notes: GENE_ASSOCIATION: (3073.1 and 3074.1) or (3074.1) or (3073.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.52 Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12706724,PMID:8993162 NOTES:NCD
type: Reaction
reversible: false

metaR EX glyc LPAREN e RPAREN
kinetic law: MODEL1310110063#
reactant: MODEL1310110063#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Glycerol exchange
type: Reaction

metaR PECTCHLe
kinetic law: MODEL1310110063#
product: MODEL1310110063#
reactant: MODEL1310110063#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: Binding of pectins with taurocholate in the intestinal lumen, reducing serum cholsterol levels.
type: Reaction

metaR S6T12g
type: Reaction
fast: false
name: galactose/N-acetylglucosamine 6-O-sulfotransferase, Golgi apparatus
modifier: MODEL1310110063#
is: SBO:0000176
kinetic law: MODEL1310110063#
product: MODEL1310110063#
notes: GENE_ASSOCIATION: (23563.1) or (9435.1) or (10164.1) or (4166.1) or (23563.2) SUBSYSTEM: Keratan sulfate synthesis EC Number: Confidence Level: 4 AUTHORS: PMID:10330415,PMID:10491328,PMID:10913333,PMID:11278593,PMID:12403612,PMID:12855678,PMID:9722682 NOTES:NCD
reactant: MODEL1310110063#
is described by: ECO:0000000
reversible: false

metaR DOPASFt
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 1 AUTHORS: NOTES:SAB excretion of dopamine sulfate
fast: false
name: Dopamine 3-0-sulfate transport (diffusion)
product: MODEL1310110063#
is described by: ECO:0000000
is: SBO:0000185
reversible: false
type: Reaction
kinetic law: MODEL1310110063#
reactant: MODEL1310110063#

metaM fpram c
boundary condition: false
notes: FORMULA: C8H15N3O8P CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC01329 EHMN_ABBREVIATION: C04640
initial amount: NaN
is: HMDB06211
constant: false
name: 2-(Formamido)-N1-(5-phospho-D-ribosyl)acetamidine
has only substance units: false
is: CHEBI:58478
initial concentration: 1.0
is: C04640
is: SBO:0000247
type: Species

metaR FACOAL226
reversible: true
reactant: MODEL1310110063#
fast: false
is: SBO:0000176
kinetic law: MODEL1310110063#
modifier: MODEL1310110063#
name: fatty-acid--CoA ligase
type: Reaction
notes: GENE_ASSOCIATION: (2180.1) SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 4 AUTHORS: PMID:15292367 NOTES:NJ
is described by: ECO:0000000
product: MODEL1310110063#
is version of: http://identifiers.org/ec-code/6.2.1.3

metaR ALACYSNaEx
reversible: false
notes: GENE_ASSOCIATION: (6509.1) or (6510.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14530974 NOTES:SAB see Kanai and Hediger 2004 (2003), PMID 14530974
fast: false
kinetic law: MODEL1310110063#
reactant: MODEL1310110063#
is: SBO:0000185
type: Reaction
name: L-alanine/L-cysteine Na-dependent exchange (Ala-L in)
is described by: ECO:0000269
modifier: MODEL1310110063#
product: MODEL1310110063#

metaM 2dr1p c
boundary condition: false
type: Species
is: SBO:0000247
initial amount: NaN
name: 2-Deoxy-D-ribose 1-phosphate
is: HMDB01351
has only substance units: false
is: C00672
is: CHEBI:58576
constant: false
notes: FORMULA: C5H9O7P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00489 EHMN_ABBREVIATION: C00672
initial concentration: 1.0

metaM pa hs c
has only substance units: false
initial concentration: 1.0
is: SBO:0000247
is: CHEBI:57739
boundary condition: false
constant: false
type: Species
initial amount: NaN
name: phosphatidate(2-)
notes: FORMULA: C3H5O4PFULLRCO2FULLR2CO2 CHARGE: -2 EHMN_ABBREVIATION: C00416

metaM lnlncgcoa c
notes: FORMULA: C39H60N7O17P3S CHARGE: -4 INCHI: InChI=1S/C39H64N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-30(48)67-23-22-41-29(47)20-21-42-37(51)34(50)39(2,3)25-60-66(57,58)63-65(55,56)59-24-28-33(62-64(52,53)54)32(49)38(61-28)46-27-45-31-35(40)43-26-44-36(31)46/h8-9,11-12,14-15,26-28,32-34,38,49-50H,4-7,10,13,16-25H2,1-3H3,(H,41,47)(H,42,51)(H,55,56)(H,57,58)(H2,40,43,44)(H2,52,53,54)/p-4/b9-8-,12-11-,15-14-/t28-,32-,33-,34+,38-/m1/s1 EHMN_ABBREVIATION: C03035
type: Species
initial amount: NaN
is: SBO:0000247
constant: false
is: HMDB06368
name: gamma-linolenoyl-CoA(4-)
initial concentration: 1.0
boundary condition: false
is: CHEBI:57363
has only substance units: false

metaR EX ddece1crn
kinetic law: MODEL1310110063#
reactant: MODEL1310110063#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for dodecenoyl carnitine
type: Reaction

metaR r2200
reversible: true
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.5
modifier: MODEL1310110063#
is: SBO:0000185
product: MODEL1310110063#
type: Reaction
reactant: MODEL1310110063#
fast: false
is described by: ECO:0000000
kinetic law: MODEL1310110063#
notes: GENE_ASSOCIATION: (6566.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:

metaM tetpent6 e
constant: false
is: SBO:0000247
name: tetracosapentaenoic acid, n-6
type: Species
initial concentration: 1.0
boundary condition: false
notes: FORMULA: C24H37O2 CHARGE: -1 INCHI: InChI=1/C24H38O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-24(25)26/h6-7,9-10,12-13,15-16,18-19H,2-5,8,11,14,17,20-23H2,1H3,(H,25,26)/b7-6-,10-9-,13-12-,16-15-,19-18-
has only substance units: false
initial amount: NaN
is: HMDB06322

http://identifiers.org/biomodels.db/MODEL1310110063#_f8c92310_46a8_42ff_bdf9_60700947b2be
is: SBO:0000252
has only substance units: false
initial concentration: NaN
initial amount: NaN
type: Species
boundary condition: true
is: Q8IWU9
constant: false
is encoded by: hsa:121278
name: TPH2

http://identifiers.org/biomodels.db/MODEL1310110063#_d613b5c3_4900_41c7_95ab_f049941a1953
is encoded by: hsa:8867
constant: false
initial amount: NaN
type: Species
initial concentration: NaN
name: SYNJ1
is: SBO:0000252
boundary condition: true
is: C9JFZ1
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110063#_a8fb6ca3_0fee_488a_b2c8_807e7087b843
type: Species
is encoded by: hsa:4952
name: OCRL
initial amount: NaN
is: SBO:0000252
initial concentration: NaN
constant: false
has only substance units: false
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110063#_edcc0436_4773_4993_a545_03da58612de2
is: SBO:0000252
is encoded by: hsa:3157
constant: false
boundary condition: true
initial concentration: NaN
has only substance units: false
name: HMGCS1
initial amount: NaN
type: Species

http://identifiers.org/biomodels.db/MODEL1310110063#_a12c8f42_1c69_4ffd_8e96_cc00007a1314
is encoded by: hsa:6489
initial concentration: NaN
has only substance units: false
constant: false
initial amount: NaN
boundary condition: true
is: Q92185
is: SBO:0000252
name: ST8SIA1
type: Species

metaR ACITL
is: SBO:0000176
product: MODEL1310110063#
modifier: MODEL1310110063#
is version of: http://identifiers.org/ec-code/2.3.3.8
fast: false
name: ATP-Citrate lyase
type: Reaction
notes: GENE_ASSOCIATION: (47.1) or (47.2) SUBSYSTEM: Citric acid cycle EC Number: 2.3.3.8 Confidence Level: 4 AUTHORS: PMID:2295639 NOTES:ATP dependent citrate lyase. Reaction is reversible in KEGG (new EC 2.3.3.8) NCD
reactant: MODEL1310110063#
is described by: ECO:0000000
reversible: false
kinetic law: MODEL1310110063#

metaR EX ps hs LPAREN e RPAREN
kinetic law: MODEL1310110063#
reactant: MODEL1310110063#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: phosphatidylserine (homo sapiens) exchange
type: Reaction

metaR MM6B2g
modifier: MODEL1310110063#
is described by: ECO:0000000
type: Reaction
is version of: http://identifiers.org/ec-code/3.2.1.113
fast: false
is: SBO:0000176
notes: GENE_ASSOCIATION: (4121.1) or (57134.1) or (10905.1) SUBSYSTEM: N-glycan synthesis EC Number: 3.2.1.113 Confidence Level: 0 AUTHORS: PMID:10915796,PMID:9592125 NOTES:NCD
reactant: MODEL1310110063#
reversible: false
name: mannosyl-oligosaccharide 1,2-alpha-mannosidase, Golgi apparatus
kinetic law: MODEL1310110063#
product: MODEL1310110063#

http://identifiers.org/biomodels.db/MODEL1310110063#_8d0fdfe5_9b54_426f_853d_0a445180d554
has only substance units: false
is encoded by: hsa:39
boundary condition: true
type: Species
is: Q9BWD1
is: SBO:0000252
initial amount: NaN
initial concentration: NaN
name: ACAT2
constant: false

metaR r0908
kinetic law: MODEL1310110063#
fast: false
is described by: ECO:0000000
reversible: true
reactant: MODEL1310110063#
product: MODEL1310110063#
type: Reaction
is: SBO:0000185
name: Postulated transport reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:3988731,PMID:6706970,PMID:7050120 NOTES:

metaR r0909
kinetic law: MODEL1310110063#
reactant: MODEL1310110063#
reversible: true
is described by: ECO:0000000
is: SBO:0000185
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:3988731,PMID:6706970,PMID:7050120 NOTES:
type: Reaction
name: Transport reaction
product: MODEL1310110063#

metaR EX c6crn
kinetic law: MODEL1310110063#
reactant: MODEL1310110063#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for hexanoyl carnitine
type: Reaction

metaM tetpent6 c
name: tetracosapentaenoic acid, n-6
notes: FORMULA: C24H37O2 CHARGE: -1 INCHI: InChI=1/C24H38O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-24(25)26/h6-7,9-10,12-13,15-16,18-19H,2-5,8,11,14,17,20-23H2,1H3,(H,25,26)/b7-6-,10-9-,13-12-,16-15-,19-18-
initial concentration: 1.0
type: Species
is: HMDB06322
has only substance units: false
initial amount: NaN
boundary condition: false
constant: false
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110063#_1db1177c_47db_46d5_8df4_f7857bd078d6
name: _R33828_1_c
has only substance units: false
type: Species
is encoded by: hsa:R33828
boundary condition: true
is: SBO:0000252
initial concentration: NaN
constant: false
initial amount: NaN

metaM dhap e
initial concentration: 1.0
notes: FORMULA: C3H5O6P CHARGE: -2 INCHI: InChI=1S/C3H7O6P/c4-1-3(5)2-9-10(6,7)8/h4H,1-2H2,(H2,6,7,8)/p-2 HEPATONET_1.0_ABBREVIATION: HC00109 EHMN_ABBREVIATION: C00111
type: Species
has only substance units: false
is: CHEBI:57642
name: glycerone phosphate(2-)
constant: false
is: HMDB01473
boundary condition: false
initial amount: NaN
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110063#_841e1b52_0c02_4079_9f16_cf4f89b3fd3d
initial amount: NaN
has only substance units: false
is encoded by: hsa:6487
type: Species
name: ST3GAL3
is: SBO:0000252
constant: false
initial concentration: NaN
boundary condition: true

metaM arachcrn c
initial concentration: 1.0
is: HMDB06460
initial amount: NaN
name: arachidyl carnitine
type: Species
boundary condition: false
constant: false
has only substance units: false
is: SBO:0000247
notes: FORMULA: C27H53NO4 CHARGE: 0 INCHI: InChI=1/C27H53NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-27(31)32-25(23-26(29)30)24-28(2,3)4/h25H,5-24H2,1-4H3

metaM C05957 r
initial concentration: 1.0
is: SBO:0000247
type: Species
notes: FORMULA: C20H29O4 CHARGE: -1 INCHI: InChI=1S/C20H30O4/c1-2-3-6-10-17(21)13-14-18-16(12-15-19(18)22)9-7-4-5-8-11-20(23)24/h4,7,12-18,21H,2-3,5-6,8-11H2,1H3,(H,23,24)/b7-4-,14-13+/t16-,17-,18+/m0/s1 EHMN_ABBREVIATION: C05957
has only substance units: false
constant: false
boundary condition: false
is: CHEBI:27485
is: HMDB02710
initial amount: NaN
name: Prostaglandin J2

metaM ksi pre19 g
boundary condition: false
notes: FORMULA: C171H275N12O137S5X CHARGE: -6
is: HMDB00175
is: SBO:0000247
type: Species
constant: false
is: CHEBI:58053
is: C00130
initial concentration: 1.0
initial amount: NaN
name: keratan sulfate I biosynthesis, precursor 19
has only substance units: false

metaM octdececrn m
name: octadecenoyl carnitine (hypothetical, position of double bond unknown)
is: HMDB06351
is: SBO:0000247
has only substance units: false
notes: FORMULA: C25H47NO4 CHARGE: 0
boundary condition: false
constant: false
initial amount: NaN
initial concentration: 1.0
type: Species

metaM dca e
is: C02838
name: Decanoate (n-C10:0)
is: HMDB00791
initial concentration: 1.0
boundary condition: false
notes: FORMULA: C10H19O2 CHARGE: -1
is: SBO:0000247
has only substance units: false
initial amount: NaN
type: Species
constant: false

http://identifiers.org/biomodels.db/MODEL1310110063#_f9b26077_5d3c_44e7_93e8_1c982f6899df
initial amount: NaN
is: SBO:0000252
boundary condition: true
type: Species
initial concentration: NaN
name: PDE9A
constant: false
is encoded by: hsa:5152
has only substance units: false

metaR UGLT
reversible: true
fast: false
kinetic law: MODEL1310110063#
reactant: MODEL1310110063#
product: MODEL1310110063#
is version of: http://identifiers.org/ec-code/2.7.7.12
is described by: ECO:0000000
name: UDPglucose--hexose-1-phosphate uridylyltransferase
notes: GENE_ASSOCIATION: (2592.1) or (2592.3) or (2592.2) SUBSYSTEM: Galactose metabolism EC Number: 2.7.7.12 Confidence Level: 0 AUTHORS: PMID:12923184 NOTES:NCD
is: SBO:0000176
modifier: MODEL1310110063#
type: Reaction

metaM CE5162 r
notes: FORMULA: C39H62N7O17P3S CHARGE: -4 INCHI: InChI=1/C39H66N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-30(48)67-23-22-41-29(47)20-21-42-37(51)34(50)39(2,3)25-60-66(57,58)63-65(55,56)59-24-28-33(62-64(52,53)54)32(49)38(61-28)46-27-45-31-35(40)43-26-44-36(31)46/h11-12,18-19,26-28,32-34,38,49-50H,4-10,13-17,20-25H2,1-3H3,(H,41,47)(H,42,51)(H,55,56)(H,57,58)(H2,40,43,44)(H2,52,53,54)/p-4/b12-11-,19-18+/t28-,32+,33+,34u,38-/m0/s1 EHMN_ABBREVIATION: CE5162
initial concentration: 1.0
has only substance units: false
is: SBO:0000247
name: trans,cis-2,9-octadecadienoyl-CoA
type: Species
constant: false
boundary condition: false
is: CHEBI:57923
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110063#_d0bf8f41_6a9f_4003_89f4_3e6fad7bf0f8
is: P19440
is encoded by: hsa:2678
has only substance units: false
initial concentration: NaN
boundary condition: true
name: GGT1
type: Species
initial amount: NaN
constant: false
is: SBO:0000252

metaM dag hs e
initial amount: NaN
is: CHEBI:18035
boundary condition: false
type: Species
name: diglyceride
initial concentration: 1.0
is: SBO:0000247
constant: false
has only substance units: false
notes: FORMULA: C3H6OFULLRCO2FULLR2CO2 CHARGE: 0

metaM pcrn x
name: propionyl-carnitine
initial concentration: 1.0
initial amount: NaN
notes: FORMULA: C10H19NO4 CHARGE: 0 INCHI: InChI=1/C10H19NO4/c1-5-10(14)15-8(6-9(12)13)7-11(2,3)4/h8H,5-7H2,1-4H3
is: http://identifiers.org/pubchem.compound/107738
type: Species
has only substance units: false
constant: false
boundary condition: false
is: SBO:0000247
is: HMDB00824

metaR CMPSAS
fast: false
is version of: http://identifiers.org/ec-code/2.7.7.43
name: CMP sialic acid synthase
is: SBO:0000176
reactant: MODEL1310110063#
type: Reaction
product: MODEL1310110063#
reversible: false
notes: GENE_ASSOCIATION: (55907.1) SUBSYSTEM: Aminosugar metabolism EC Number: 2.7.7.43 Confidence Level: 2 AUTHORS: PMID:9689047 NOTES:NCD
kinetic law: MODEL1310110063#
modifier: MODEL1310110063#
is described by: ECO:0000304

http://identifiers.org/biomodels.db/MODEL1310110063#_c32c8151_2f4b_4113_a7fa_4d520633a905
constant: false
is: O75752
is: SBO:0000252
initial concentration: NaN
initial amount: NaN
name: B3GALNT1
has only substance units: false
is encoded by: hsa:8706
boundary condition: true
type: Species

metaR S23T2g
modifier: MODEL1310110063#
product: MODEL1310110063#
type: Reaction
reversible: false
reactant: MODEL1310110063#
fast: false
is: SBO:0000176
notes: GENE_ASSOCIATION: (6484.1) or (6482.1) or (6483.1) or (6482.2) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.99.4 Confidence Level: 4 AUTHORS: PMID:10504389,PMID:7901202,PMID:8027041,PMID:8288606,PMID:8920913 NOTES:NCD
is version of: http://identifiers.org/ec-code/2.4.99.4
name: beta-galactoside alpha-2,3-sialyltransferase (core 2)
is described by: ECO:0000000
kinetic law: MODEL1310110063#

metaM c10dc x
initial amount: NaN
name: sebacoyl carnitine
is: HMDB00651
type: Species
has only substance units: false
constant: false
notes: FORMULA: C17H30NO6 CHARGE: -1
boundary condition: false
is: SBO:0000247
initial concentration: 1.0

metaR EX elaid LPAREN e RPAREN
kinetic law: MODEL1310110063#
reactant: MODEL1310110063#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: elaidic acid exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110063#_b1d1a9f7_fafa_401a_ae0d_29240ca536e8
boundary condition: true
type: Species
has only substance units: false
is: SBO:0000252
initial concentration: NaN
name: HMGCR
constant: false
initial amount: NaN
is: P04035
is encoded by: hsa:3156

metaM idour c
constant: false
has only substance units: false
type: Species
name: L-iduronate
initial amount: NaN
is: CHEBI:21338
is: SBO:0000247
notes: FORMULA: C6H9O7 CHARGE: -1 INCHI: InChI=1S/C6H10O7/c7-1-2(8)3(9)4(10)5(11)6(12)13/h1-5,8-11H,(H,12,13)/p-1/t2-,3+,4-,5+/m0/s1
boundary condition: false
is: HMDB02704
initial concentration: 1.0

metaR EX pnto R LPAREN e RPAREN
kinetic law: MODEL1310110063#
reactant: MODEL1310110063#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: (R)-Pantothenate exchange
type: Reaction

metaR EX ha pre1 LPAREN e RPAREN
kinetic law: MODEL1310110063#
reactant: MODEL1310110063#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: hyaluronan biosynthesis, precursor 1 exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110063#_c76bb457_e977_4af2_b3b7_7c4090293848
type: Species
initial amount: NaN
initial concentration: NaN
is: P49915
has only substance units: false
is encoded by: hsa:8833
boundary condition: true
is: SBO:0000252
constant: false
name: GMPS

metaR RE1826C
name: RE1826
reactant: MODEL1310110063#
product: MODEL1310110063#
type: Reaction
is described by: ECO:0000000
reversible: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Bile acid synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:11454857 NOTES:
kinetic law: MODEL1310110063#
is: SBO:0000176
fast: false

metaR FAEL183
type: Reaction
notes: GENE_ASSOCIATION: (6785.1) SUBSYSTEM: Fatty acid synthesis EC Number: 2.3.1.86 Confidence Level: 4 AUTHORS: PMID:11138005,PMID:15189125 NOTES:fatty acid elongation step NJ
fast: false
name: fatty-acyl-CoA elongation (n-C18:3CoA)
kinetic law: MODEL1310110063#
product: MODEL1310110063#
is described by: ECO:0000000
reversible: false
modifier: MODEL1310110063#
reactant: MODEL1310110063#
is: SBO:0000176

metaR GLCNACASE3ly
reactant: MODEL1310110063#
type: Reaction
modifier: MODEL1310110063#
notes: GENE_ASSOCIATION: (4669.1) SUBSYSTEM: Heparan sulfate degradation EC Number: 3.2.1.50 Confidence Level: 4 AUTHORS: PMID:1783617,PMID:8776591,PMID:8993162 NOTES:NCD
kinetic law: MODEL1310110063#
fast: false
reversible: false
product: MODEL1310110063#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.2.1.50
is described by: ECO:0000000
name: alpha-N-acetylglucosaminidase, lysosomal

http://identifiers.org/biomodels.db/MODEL1310110063#_f3c18b4f_e03f_4950_87bb_915282a99fe3
boundary condition: true
is: SBO:0000252
has only substance units: false
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:2348
is: P15328
type: Species
name: FOLR1
constant: false

metaR GUACYC
notes: GENE_ASSOCIATION: (2977.1 and 2983.1) or (4882.2) or (2982.1 and 2974.1) or (2986.1) or (4882.1) or (2984.1) or (4881.1) or (2977.1 and 2974.1) or (3000.1) or (2982.1 and 2983.1) SUBSYSTEM: Nucleotide interconversion EC Number: 4.6.1.2 Confidence Level: 4 AUTHORS: PMID:10449911,PMID:10777682,PMID:11565546,PMID:11851379,PMID:1352257,PMID:14748740,PMID:15371450,PMID:7601467,PMID:7761400,PMID:7777544,PMID:7954658,PMID:8838319,PMID:9097965,PMID:9742212 NOTES:IT
reversible: false
modifier: MODEL1310110063#
product: MODEL1310110063#
reactant: MODEL1310110063#
name: guanylate cyclase
is version of: http://identifiers.org/ec-code/4.6.1.2
is described by: ECO:0000269
is: SBO:0000176
type: Reaction
fast: false
kinetic law: MODEL1310110063#

http://identifiers.org/biomodels.db/MODEL1310110063#_26172b73_ed34_4f65_9be2_191af620dfa8
is encoded by: hsa:5152
initial concentration: NaN
is: SBO:0000252
has only substance units: false
type: Species
boundary condition: true
constant: false
name: PDE9A
initial amount: NaN

metaM nrvnccoa c
notes: FORMULA: C45H76N7O17P3S CHARGE: -4 INCHI: InChI=1/C45H80N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-24-25-36(54)73-29-28-47-35(53)26-27-48-43(57)40(56)45(2,3)31-66-72(63,64)69-71(61,62)65-30-34-39(68-70(58,59)60)38(55)44(67-34)52-33-51-37-41(46)49-32-50-42(37)52/h11-12,32-34,38-40,44,55-56H,4-10,13-31H2,1-3H3,(H,47,53)(H,48,57)(H,61,62)(H,63,64)(H2,46,49,50)(H2,58,59,60)/b12-11-/t34-,38-,39-,40?,44-/m1/s1
is: SBO:0000247
initial concentration: 1.0
constant: false
is: C16532
name: nervonyl coenzyme A
boundary condition: false
initial amount: NaN
type: Species
has only substance units: false

metaM pydx c
has only substance units: false
is: CHEBI:17310
notes: FORMULA: C8H9NO3 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00227 EHMN_ABBREVIATION: C00250
is: C00250
type: Species
is: HMDB01545
boundary condition: false
is: SBO:0000247
initial concentration: 1.0
name: Pyridoxal
initial amount: NaN
constant: false

metaR PIt7
is: SBO:0000185
reversible: true
notes: GENE_ASSOCIATION: (10050.1) or (10786.1) or (10246.1) or (6568.1) or (6569.1) or (10568.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12750889,PMID:12811560,PMID:8815811 NOTES:Merged GPRs from PIt7 and PIt7r. May 2011 IT
kinetic law: MODEL1310110063#
product: MODEL1310110063#
modifier: MODEL1310110063#
type: Reaction
reactant: MODEL1310110063#
name: phosphate transport in/out via three Na+ symporter
fast: false
is described by: ECO:0000269

metaM r5p c
is: HMDB00618
boundary condition: false
notes: FORMULA: C5H9O8P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00115 EHMN_ABBREVIATION: C00117
is: C00117
is: CHEBI:18189
initial amount: NaN
type: Species
initial concentration: 1.0
name: alpha-D-Ribose 5-phosphate
has only substance units: false
is: SBO:0000247
constant: false

http://identifiers.org/biomodels.db/MODEL1310110063#_db1ed38c_6a33_409c_a7f5_8fd3e4a889a9
initial concentration: NaN
initial amount: NaN
is: SBO:0000252
name: PDE9A
boundary condition: true
is encoded by: hsa:5152
constant: false
type: Species
has only substance units: false

metaM ksi pre32 g
constant: false
initial concentration: 1.0
initial amount: NaN
is: CHEBI:28067
notes: FORMULA: C227H362N16O192S10X CHARGE: -11
has only substance units: false
boundary condition: false
name: keratan sulfate I biosynthesis, precursor 32
is: SBO:0000247
type: Species

http://identifiers.org/biomodels.db/MODEL1310110063#_d8a7ffb0_9d8f_4e2c_8df9_e536d046c101
type: Species
boundary condition: true
constant: false
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:2650
has only substance units: false
is: Q02742
name: GCNT1
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110063#_e829e5ab_bebe_4688_9c1c_e13aad13ffea
initial amount: NaN
constant: false
name: ALDH9A1
is: SBO:0000252
has only substance units: false
type: Species
initial concentration: NaN
is: P49189
boundary condition: true
is encoded by: hsa:223

metaM dca c
type: Species
boundary condition: false
constant: false
is: HMDB00791
has only substance units: false
initial concentration: 1.0
is: C02838
initial amount: NaN
name: Decanoate (n-C10:0)
is: SBO:0000247
notes: FORMULA: C10H19O2 CHARGE: -1

metaM idour e
notes: FORMULA: C6H9O7 CHARGE: -1 INCHI: InChI=1S/C6H10O7/c7-1-2(8)3(9)4(10)5(11)6(12)13/h1-5,8-11H,(H,12,13)/p-1/t2-,3+,4-,5+/m0/s1
boundary condition: false
initial concentration: 1.0
constant: false
is: HMDB02704
initial amount: NaN
name: L-iduronate
type: Species
is: CHEBI:21338
has only substance units: false
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110063#_c8479342_37d5_44b8_8681_61fec0f96955
is encoded by: hsa:NM 013421
name: _NM_013421_1_e
is: SBO:0000252
initial concentration: NaN
initial amount: NaN
constant: false
boundary condition: true
type: Species
has only substance units: false

metaR UDPGLCAter
type: Reaction
fast: false
reactant: MODEL1310110063#
is: SBO:0000185
product: MODEL1310110063#
reversible: true
kinetic law: MODEL1310110063#
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (23169.1) SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 4 AUTHORS: PMID:11322953 NOTES:NCD
name: UDPGlcA endoplasmic reticulum transport via UMP antiport
modifier: MODEL1310110063#

metaR THRGLNNaEx
reactant: MODEL1310110063#
name: L-threonine/L-glutamine Na-dependent exchange (Thr-L in)
product: MODEL1310110063#
reversible: false
notes: GENE_ASSOCIATION: (6510.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14530974 NOTES:SAB see Kanai and Hediger 2004 (2003), PMID 14530974
kinetic law: MODEL1310110063#
fast: false
is described by: ECO:0000269
modifier: MODEL1310110063#
is: SBO:0000185
type: Reaction

metaR DOLPH Uer
notes: GENE_ASSOCIATION: SUBSYSTEM: N-glycan synthesis EC Number: 3.1.3.51 Confidence Level: 0 AUTHORS: PMID:11425794 NOTES:
name: Dolichol-phosphate phosphohydrolase, human (uterus)
is: SBO:0000176
fast: false
kinetic law: MODEL1310110063#
reversible: false
is described by: ECO:0000000
reactant: MODEL1310110063#
product: MODEL1310110063#
type: Reaction

metaM for m
notes: FORMULA: CH1O2 CHARGE: -1 INCHI: InChI=1S/CH2O2/c2-1-3/h1H,(H,2,3)/p-1 HEPATONET_1.0_ABBREVIATION: HC00061 EHMN_ABBREVIATION: C00058
boundary condition: false
initial concentration: 1.0
has only substance units: false
is: SBO:0000247
is: HMDB00142
is: CHEBI:15740
name: formate
type: Species
initial amount: NaN
constant: false

metaM s2l2n2m2mn l
initial amount: NaN
is: HMDB00573
is: CHEBI:30825
boundary condition: false
notes: FORMULA: C76H123N5O57 CHARGE: -2
name: de-Fuc, reducing GlcNAc removed form of PA6 (w/o peptide linkage)
initial concentration: 1.0
constant: false
has only substance units: false
is: SBO:0000247
type: Species

metaR PIt8
modifier: MODEL1310110063#
type: Reaction
is: SBO:0000185
kinetic law: MODEL1310110063#
product: MODEL1310110063#
is described by: ECO:0000006
reactant: MODEL1310110063#
fast: false
reversible: true
notes: GENE_ASSOCIATION: (6574.1) or (6575.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12759754 NOTES:MM
name: phosphate transport in/out via Na+ symporter

metaM HC02207 c
boundary condition: false
name: prostaglandin-c2
is: SBO:0000247
initial amount: NaN
has only substance units: false
is: CHEBI:27555
constant: false
type: Species
initial concentration: 1.0
notes: FORMULA: C20H29O4 CHARGE: -1 INCHI: InChI=1S/C20H30O4/c1-2-3-6-9-17(21)14-12-16-13-15-19(22)18(16)10-7-4-5-8-11-20(23)24/h4,7,12-14,17-18,21H,2-3,5-6,8-11,15H2,1H3,(H,23,24)/b7-4-,14-12+/t17-,18+/m0/s1 EHMN_ABBREVIATION: C05955

metaM pydam c
notes: FORMULA: C8H13N2O2 CHARGE: 1 HEPATONET_1.0_ABBREVIATION: HC00416 EHMN_ABBREVIATION: C00534
is: C00534
has only substance units: false
is: HMDB01431
is: SBO:0000247
name: Pyridoxamine
initial concentration: 1.0
is: CHEBI:57761
initial amount: NaN
type: Species
boundary condition: false
constant: false

metaR r0651
type: Reaction
reactant: MODEL1310110063#
notes: GENE_ASSOCIATION: (10637.1) or (5831.1) or (29920.1) or (65263.1) SUBSYSTEM: Bile acid synthesis EC Number: 6.2.1.7 Confidence Level: 0 AUTHORS: PMID:10749848,PMID:10884298,PMID:15026425,PMID:438652,PMID:6173037 NOTES:
name: Chenodeoxycholate:CoA ligase (AMP-forming) Bile acid biosynthesis EC:6.2.1.7
product: MODEL1310110063#
reversible: true
kinetic law: MODEL1310110063#
is described by: ECO:0000000
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.5.1.2
fast: false
modifier: MODEL1310110063#

http://identifiers.org/biomodels.db/MODEL1310110063#_cb0b55fe_8574_45d4_bc9d_d4d4bb76e55a
boundary condition: true
is encoded by: hsa:29920
type: Species
initial concentration: NaN
constant: false
has only substance units: false
is: Q96C36
is: SBO:0000252
initial amount: NaN
name: PYCR2

metaR KSII CORE2t
kinetic law: MODEL1310110063#
type: Reaction
name: keratan sulfate II (core2) transport, golgi to extracellular
product: MODEL1310110063#
fast: false
is: SBO:0000185
reactant: MODEL1310110063#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:
reversible: false
is described by: ECO:0000000

metaM lys L e
is: SBO:0000247
is: HMDB00182
boundary condition: false
initial concentration: 1.0
name: L-lysinium(1+)
constant: false
is: CHEBI:32551
has only substance units: false
notes: FORMULA: C6H15N2O2 CHARGE: 1 INCHI: InChI=1S/C6H14N2O2/c7-4-2-1-3-5(8)6(9)10/h5H,1-4,7-8H2,(H,9,10)/p+1/t5-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00053 EHMN_ABBREVIATION: C00047
type: Species
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110063#_70484d22_5b7e_4b70_9bb7_1c4b7d35b9d6
has only substance units: false
initial concentration: NaN
name: _AI090874_1_c
boundary condition: true
is: SBO:0000252
is encoded by: hsa:AI090874
constant: false
initial amount: NaN
type: Species

metaR RE2659R
is described by: ECO:0000000
product: MODEL1310110063#
notes: GENE_ASSOCIATION: SUBSYSTEM: Vitamin A metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:9647871 NOTES:
kinetic law: MODEL1310110063#
reversible: true
reactant: MODEL1310110063#
is: SBO:0000176
type: Reaction
fast: false
name: RE2659

metaM pydx e
is: CHEBI:17310
is: HMDB01545
is: SBO:0000247
constant: false
name: Pyridoxal
initial amount: NaN
boundary condition: false
notes: FORMULA: C8H9NO3 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00227 EHMN_ABBREVIATION: C00250
is: C00250
type: Species
has only substance units: false
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110063#_62650a06_ee68_4ed7_82d3_1f864b73357e
constant: false
initial amount: NaN
is: Q8N1Q1
name: CA13
initial concentration: NaN
boundary condition: true
has only substance units: false
is encoded by: hsa:377677
is: SBO:0000252
type: Species

metaM prostgi2 c
notes: FORMULA: C20H31O5 CHARGE: -1 INCHI: InChI=1S/C20H32O5/c1-2-3-4-7-14(21)10-11-16-17-12-15(8-5-6-9-20(23)24)25-19(17)13-18(16)22/h8,10-11,14,16-19,21-22H,2-7,9,12-13H2,1H3,(H,23,24)/p-1/b11-10+,15-8-/t14-,16+,17+,18+,19-/m0/s1 EHMN_ABBREVIATION: C01312
name: prostaglandin I2(1-)
is: SBO:0000247
has only substance units: false
type: Species
is: CHEBI:57403
initial amount: NaN
constant: false
initial concentration: 1.0
is: HMDB01335
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110063#_8cc1666c_1f2c_42ee_a068_8fedcc59ef60
is: SBO:0000252
type: Species
initial concentration: NaN
constant: false
name: PIGO
is encoded by: hsa:84720
initial amount: NaN
has only substance units: false
boundary condition: true
is: Q8TEQ8

metaM fn2m2masn g
has only substance units: false
is: CHEBI:32984
initial amount: NaN
constant: false
boundary condition: false
name: N4-{N-Acetyl-beta-D-glucosaminyl-(1,2)-alpha-D-mannosyl-(1,3)-[N-acetyl-beta-D-glucosaminyl-(1,2)-alpha-D-mannosyl-(1,6)]-beta-D-mannosyl-(1,4)-N-acetyl-beta-D-glucosaminyl-(1,4)-[alpha-L-fucosyl-(1,6)]-N-acetyl-beta-D-glucosaminyl}asparagine
notes: FORMULA: C56H93N4O39X CHARGE: 0 INCHI: InChI=1S/C60H100N6O42/c1-14-32(77)42(87)45(90)57(96-14)94-13-26-48(40(85)28(62-15(2)72)52(97-26)66-27(76)6-19(61)53(92)93)104-56-31(65-18(5)75)41(86)47(24(11-71)102-56)105-58-46(91)49(106-60-51(44(89)36(81)23(10-70)101-60)108-55-30(64-17(4)74)39(84)34(79)21(8-68)99-55)37(82)25(103-58)12-95-59-50(43(88)35(80)22(9-69)100-59)107-54-29(63-16(3)73)38(83)33(78)20(7-67)98-54/h14,19-26,28-52,54-60,67-71,77-91H,6-13,61H2,1-5H3,(H,62,72)(H,63,73)(H,64,74)(H,65,75)(H,66,76)(H,92,93)/t14-,19-,20+,21+,22+,23+,24+,25+,26+,28+,29+,30+,31+,32+,33+,34+,35+,36+,37+,38+,39+,40+,41+,42+,43-,44-,45-,46-,47+,48+,49-,50-,51-,52+,54-,55-,56-,57+,58-,59-,60+/m0/s1
type: Species
is: SBO:0000247
initial concentration: 1.0

metaM bildglcur r
name: bis(beta-glucosyluronate)bilirubin
boundary condition: false
has only substance units: false
type: Species
is: HMDB03325
is: CHEBI:58471
initial amount: NaN
is: SBO:0000247
initial concentration: 1.0
notes: FORMULA: C45H50N4O18 CHARGE: -2 INCHI: InChI=1S/C45H52N4O18/c1-7-20-19(6)40(58)49-27(20)14-25-18(5)23(10-12-31(51)65-45-37(57)33(53)35(55)39(67-45)43(62)63)29(47-25)15-28-22(17(4)24(46-28)13-26-16(3)21(8-2)41(59)48-26)9-11-30(50)64-44-36(56)32(52)34(54)38(66-44)42(60)61/h7-8,13-14,32-39,44-47,52-57H,1-2,9-12,15H2,3-6H3,(H,48,59)(H,49,58)(H,60,61)(H,62,63)/p-2/b26-13+,27-14+/t32-,33-,34-,35-,36+,37+,38-,39-,44+,45+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01616 EHMN_ABBREVIATION: C05787
constant: false

metaR PI345P5P
product: MODEL1310110063#
kinetic law: MODEL1310110063#
reactant: MODEL1310110063#
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/3.1.3.86
notes: GENE_ASSOCIATION: (3633.1) or (27124.1) or (3635.1) or (3636.1) or (8871.1) or (56623.1) or (8867.2) or (27124.2) or (8867.1) or (3632.1) SUBSYSTEM: Inositol phosphate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:10358929 NOTES:NCD
reversible: false
modifier: MODEL1310110063#
type: Reaction
name: phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase
is version of: http://identifiers.org/ec-code/3.1.3.36
fast: false
is version of: http://identifiers.org/ec-code/3.1.3.56
is: SBO:0000176

metaR r0652
reversible: true
is described by: ECO:0000000
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.5.1.2
reactant: MODEL1310110063#
product: MODEL1310110063#
modifier: MODEL1310110063#
notes: GENE_ASSOCIATION: (10637.1) or (5831.1) or (29920.1) or (65263.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.1.38 Confidence Level: 0 AUTHORS: PMID:12654921 NOTES:
kinetic law: MODEL1310110063#
name: trans-Tetradec-2-enoyl-CoA reductase Fatty acid elongation in mitochondria EC:1.3.1.38
type: Reaction
fast: false

metaR S4TASE3ly
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.1.6.12
notes: GENE_ASSOCIATION: (411.1) or (411.2) SUBSYSTEM: Chondroitin sulfate degradation EC Number: 3.1.6.12 Confidence Level: 4 AUTHORS: PMID:1968043,PMID:2303452 NOTES:NCD
product: MODEL1310110063#
modifier: MODEL1310110063#
type: Reaction
name: N-acetylgalactosamine-4-sulfatase, lysosomal
reversible: true
is described by: ECO:0000000
fast: false
kinetic law: MODEL1310110063#
reactant: MODEL1310110063#

metaM Rtotal3 e
type: Species
is: C00255
initial amount: NaN
has only substance units: false
notes: FORMULA: CO2FULLR3 CHARGE: -1
boundary condition: false
is: CHEBI:3554
name: R total 3 position
initial concentration: 1.0
constant: false
is: HMDB00244
is: SBO:0000247

metaR EX sprm LPAREN e RPAREN
kinetic law: MODEL1310110063#
reactant: MODEL1310110063#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: PMID:10049700,PMID:10574970,PMID:11389679,PMID:11557028,PMID:11564694,PMID:12824232,PMID:12930836,PMID:14574404,PMID:16288981,PMID:911815 NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: EX_sprm(e)
type: Reaction

metaM HC02207 e
initial concentration: 1.0
initial amount: NaN
boundary condition: false
name: prostaglandin-c2
is: CHEBI:27555
is: SBO:0000247
type: Species
constant: false
has only substance units: false
notes: FORMULA: C20H29O4 CHARGE: -1 INCHI: InChI=1S/C20H30O4/c1-2-3-6-9-17(21)14-12-16-13-15-19(22)18(16)10-7-4-5-8-11-20(23)24/h4,7,12-14,17-18,21H,2-3,5-6,8-11,15H2,1H3,(H,23,24)/b7-4-,14-12+/t17-,18+/m0/s1 EHMN_ABBREVIATION: C05955

metaR IMPC
modifier: MODEL1310110063#
name: IMP cyclohydrolase
product: MODEL1310110063#
reversible: true
notes: GENE_ASSOCIATION: (471.1) SUBSYSTEM: Purine synthesis EC Number: 3.5.4.10 Confidence Level: 4 AUTHORS: PMID:11948179,PMID:14966129,PMID:9378707 NOTES:
is described by: ECO:0000269
fast: false
is version of: http://identifiers.org/ec-code/2.1.2.3
type: Reaction
is: SBO:0000176
kinetic law: MODEL1310110063#
reactant: MODEL1310110063#

http://identifiers.org/biomodels.db/MODEL1310110063#_b0cbe84f_7737_4cff_aea1_763e194fe14f
initial amount: NaN
is: SBO:0000252
is encoded by: hsa:2990
initial concentration: NaN
is: P08236
has only substance units: false
constant: false
type: Species
name: GUSB
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110063#_37b53689_8ca6_4439_83f1_bcee63ef1a20
constant: false
boundary condition: true
is: Q8N0X4
has only substance units: false
initial concentration: NaN
is: SBO:0000252
initial amount: NaN
type: Species
is encoded by: hsa:171425
name: CLYBL

metaR q10h2tc
name: transport of ubiquinol into cytosol
kinetic law: MODEL1310110063#
is: SBO:0000185
reactant: MODEL1310110063#
product: MODEL1310110063#
type: Reaction
reversible: true
is described by: ECO:0000134
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: NOTES:

metaR ACOAD8m
notes: GENE_ASSOCIATION: (3712.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 1.3.99.10 Confidence Level: 4 AUTHORS: PMID:9214289 NOTES:MM
modifier: MODEL1310110063#
reversible: false
type: Reaction
is described by: ECO:0000269
name: acyl-CoA dehydrogenase (isovaleryl-CoA), mitochondrial
reactant: MODEL1310110063#
product: MODEL1310110063#
is: SBO:0000176
fast: false
kinetic law: MODEL1310110063#
is version of: http://identifiers.org/ec-code/1.3.99.10

metaR r2420
reactant: MODEL1310110063#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:10585886,PMID:14598172,PMID:4424886,PMID:4441366,PMID:5099217,PMID:8329439 NOTES:
is: SBO:0000185
type: Reaction
product: MODEL1310110063#
is described by: ECO:0000000
name: Mitochondrial Carrier (MC) TCDB:2.A.29.2.7
reversible: true
fast: false
kinetic law: MODEL1310110063#

metaM 4hexdtricoa x
type: Species
is: HMDB02288
is: SBO:0000247
constant: false
boundary condition: false
initial amount: NaN
initial concentration: 1.0
name: 4,7,10-hexadecatrienoylcoa
has only substance units: false
notes: FORMULA: C37H56N7O17P3S CHARGE: -4

metaM dhap c
has only substance units: false
is: C00111
initial amount: NaN
type: Species
is: CHEBI:57642
boundary condition: false
initial concentration: 1.0
is: http://identifiers.org/pubchem.compound/3411
constant: false
name: Dihydroxyacetone phosphate
is: SBO:0000247
is: HMDB01473

http://identifiers.org/biomodels.db/MODEL1310110063#_2aaab6b4_4c59_45f2_94fa_a0673ea786e6
is: Q9NUI1
has only substance units: false
initial amount: NaN
name: DECR2
boundary condition: true
type: Species
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:26063
constant: false

metaR FADH2tx
fast: false
kinetic law: MODEL1310110063#
is described by: ECO:0000000
type: Reaction
product: MODEL1310110063#
is: SBO:0000185
reactant: MODEL1310110063#
reversible: true
name: FADH2 transporter, peroxisomal
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 1 AUTHORS: NOTES:most likely NOT physiological - detailed information about the peroxisomal transporters has not yet been achieved - this transport is most likely dependent on a concomitant energy consuming reaction (human ABC peroxisomal transporters: PEX family - check in future for new research articles describing biochemistry and stoichiometry) NJ

metaR EX pi LPAREN e RPAREN
kinetic law: MODEL1310110063#
reactant: MODEL1310110063#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Phosphate exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110063#_f59e9f57_ed5d_4886_8f6c_430bc71bbd03
initial amount: NaN
has only substance units: false
boundary condition: true
is: SBO:0000252
initial concentration: NaN
is encoded by: hsa:51179
type: Species
constant: false
name: HAO2

metaM prostgi2 e
initial amount: NaN
is: SBO:0000247
boundary condition: false
is: HMDB01335
type: Species
is: CHEBI:57403
initial concentration: 1.0
notes: FORMULA: C20H31O5 CHARGE: -1 INCHI: InChI=1S/C20H32O5/c1-2-3-4-7-14(21)10-11-16-17-12-15(8-5-6-9-20(23)24)25-19(17)13-18(16)22/h8,10-11,14,16-19,21-22H,2-7,9,12-13H2,1H3,(H,23,24)/p-1/b11-10+,15-8-/t14-,16+,17+,18+,19-/m0/s1 EHMN_ABBREVIATION: C01312
constant: false
name: prostaglandin I2(1-)
has only substance units: false

metaM HC02179 c
is: CHEBI:34306
name: 20-hydroxy-arachidonate
type: Species
initial amount: NaN
boundary condition: false
constant: false
has only substance units: false
is: SBO:0000247
notes: FORMULA: C20H31O3 CHARGE: -1 INCHI: InChI=1S/C20H32O3/c21-19-17-15-13-11-9-7-5-3-1-2-4-6-8-10-12-14-16-18-20(22)23/h1,3-4,6-7,9-10,12,21H,2,5,8,11,13-19H2,(H,22,23)/b3-1-,6-4-,9-7-,12-10- EHMN_ABBREVIATION: C14748
initial concentration: 1.0

metaM dag hs c
initial amount: NaN
is: CHEBI:18035
initial concentration: 1.0
name: diglyceride
is: SBO:0000247
has only substance units: false
type: Species
boundary condition: false
constant: false
notes: FORMULA: C3H6OFULLRCO2FULLR2CO2 CHARGE: 0

metaR r0650
fast: false
is described by: ECO:0000000
is: SBO:0000176
product: MODEL1310110063#
modifier: MODEL1310110063#
is version of: http://identifiers.org/ec-code/4.1.1.36
kinetic law: MODEL1310110063#
reactant: MODEL1310110063#
name: Chenodeoxycholate:CoA ligase (AMP-forming) Bile acid biosynthesis EC:6.2.1.7
notes: GENE_ASSOCIATION: (60490.1) SUBSYSTEM: Bile acid synthesis EC Number: 6.2.1.7 Confidence Level: 0 AUTHORS: PMID:10749848,PMID:10884298,PMID:15026425,PMID:438652,PMID:6173037 NOTES:
type: Reaction
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110063#_e84c645f_2f4a_4e1b_a961_e110676bb2a7
has only substance units: false
initial concentration: NaN
type: Species
is: Q16853
constant: false
boundary condition: true
initial amount: NaN
is encoded by: hsa:8639
name: AOC3
is: SBO:0000252

metaR G14T11g
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/2.4.1.38
reactant: MODEL1310110063#
is version of: http://identifiers.org/ec-code/2.4.1.90
modifier: MODEL1310110063#
is: SBO:0000176
product: MODEL1310110063#
name: beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase, Golgi
kinetic law: MODEL1310110063#
fast: false
type: Reaction
is version of: http://identifiers.org/ec-code/2.4.1.22
notes: GENE_ASSOCIATION: (8703.1) or (8704.2) or (8704.1) or (2683.1) or (9334.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.38 Confidence Level: 4 AUTHORS: PMID:12512857,PMID:1903938,PMID:3094506,PMID:3144273,PMID:9405390,PMID:9435216 NOTES:Keratan sulfate I biosynthesis NCD
reversible: false

metaM crn x
is: HMDB00062
name: L-Carnitine
type: Species
constant: false
has only substance units: false
is: CHEBI:16347
initial amount: NaN
is: SBO:0000247
boundary condition: false
initial concentration: 1.0
notes: FORMULA: C7H15NO3 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00270 EHMN_ABBREVIATION: C00318
is: C00318

metaR B3GNT39g
modifier: MODEL1310110063#
reversible: false
is described by: ECO:0000000
fast: false
kinetic law: MODEL1310110063#
type: Reaction
reactant: MODEL1310110063#
name: UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 3, Golgi apparatus
notes: GENE_ASSOCIATION: (10331.1) SUBSYSTEM: Sphingolipid metabolism EC Number: Confidence Level: 4 AUTHORS: NOTES:NJ
is: SBO:0000176
product: MODEL1310110063#

metaR B3GALT3g
is version of: http://identifiers.org/ec-code/2.4.1.79
is: SBO:0000176
reactant: MODEL1310110063#
reversible: false
kinetic law: MODEL1310110063#
name: Beta-1,3-galactosyltransferase 3
notes: GENE_ASSOCIATION: (8706.4) or (8706.1) or (8706.3) or (8706.2) SUBSYSTEM: Sphingolipid metabolism EC Number: 2.4.1.79 Confidence Level: 4 AUTHORS: NOTES:NJ
modifier: MODEL1310110063#
fast: false
product: MODEL1310110063#
type: Reaction
is described by: ECO:0000269

metaM ksi pre7 g
boundary condition: false
is: C00130
type: Species
is: CHEBI:58053
is: SBO:0000247
constant: false
notes: FORMULA: C115H187N8O85SX CHARGE: -2
initial concentration: 1.0
has only substance units: false
initial amount: NaN
name: keratan sulfate I biosynthesis, precursor 7
is: HMDB00175

metaM 5aop m
name: 5-Amino-4-oxopentanoate
initial concentration: 1.0
has only substance units: false
type: Species
is: C00430
constant: false
is: CHEBI:17549
boundary condition: false
is: HMDB01149
notes: FORMULA: C5H9NO3 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00349 EHMN_ABBREVIATION: C00430
initial amount: NaN
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110063#_b21d460e_a5f1_4f6e_8c0d_cc7d76bbebf9
has only substance units: false
is encoded by: hsa:509
initial amount: NaN
name: ATP5C1
is: Q6I9V2
boundary condition: true
constant: false
is: SBO:0000252
initial concentration: NaN
type: Species

metaR r1742
fast: false
is described by: ECO:0000000
reversible: false
is: SBO:0000185
reactant: MODEL1310110063#
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
name: Y+LAT2 Utilized transport
product: MODEL1310110063#
modifier: MODEL1310110063#
kinetic law: MODEL1310110063#
type: Reaction

metaR MCPST
is: SBO:0000176
product: MODEL1310110063#
modifier: MODEL1310110063#
notes: GENE_ASSOCIATION: (4357.1) SUBSYSTEM: Methionine and cysteine metabolism EC Number: 2.8.1.2 Confidence Level: 4 AUTHORS: PMID:4828222 NOTES:MM AMF. assay developed to find activity in red and white blood cells
type: Reaction
is described by: ECO:0000134
is version of: http://identifiers.org/ec-code/2.8.1.2
kinetic law: MODEL1310110063#
fast: false
reversible: false
reactant: MODEL1310110063#
name: 3-mercaptopyruvate sulfurtransferase

metaM sphs1p r
initial amount: NaN
notes: FORMULA: C18H37NO5P CHARGE: -1 INCHI: InChI=1S/C18H38NO5P/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-18(20)17(19)16-24-25(21,22)23/h14-15,17-18,20H,2-13,16,19H2,1H3,(H2,21,22,23)/p-1/b15-14+/t17-,18+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01702 EHMN_ABBREVIATION: C06124
is: CHEBI:60119
name: sphingosine 1-phosphate(1-)
is: HMDB00277
type: Species
initial concentration: 1.0
has only substance units: false
boundary condition: false
is: SBO:0000247
constant: false

metaM ps hs m
boundary condition: false
is: CHEBI:18303
type: Species
notes: FORMULA: C6H11NO6PFULLRCO2FULLR2CO2 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC02006
initial amount: NaN
is: SBO:0000247
constant: false
has only substance units: false
initial concentration: 1.0
name: ps_hs[m]

http://identifiers.org/biomodels.db/MODEL1310110063#_762e3fe9_18c3_4abd_9626_cffe1cefc895
name: PLCB3
is: G5E960
initial amount: NaN
type: Species
boundary condition: true
is: SBO:0000252
initial concentration: NaN
is encoded by: hsa:5331
has only substance units: false
constant: false

metaM lnlncgcoa r
has only substance units: false
boundary condition: false
notes: FORMULA: C39H60N7O17P3S CHARGE: -4 INCHI: InChI=1S/C39H64N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-30(48)67-23-22-41-29(47)20-21-42-37(51)34(50)39(2,3)25-60-66(57,58)63-65(55,56)59-24-28-33(62-64(52,53)54)32(49)38(61-28)46-27-45-31-35(40)43-26-44-36(31)46/h8-9,11-12,14-15,26-28,32-34,38,49-50H,4-7,10,13,16-25H2,1-3H3,(H,41,47)(H,42,51)(H,55,56)(H,57,58)(H2,40,43,44)(H2,52,53,54)/p-4/b9-8-,12-11-,15-14-/t28-,32-,33-,34+,38-/m1/s1 EHMN_ABBREVIATION: C03035
is: HMDB06368
is: CHEBI:57363
constant: false
type: Species
initial amount: NaN
is: SBO:0000247
initial concentration: 1.0
name: gamma-linolenoyl-CoA(4-)

metaM CE1935 e
is: SBO:0000247
has only substance units: false
is: HMDB02329
initial concentration: 1.0
name: spermine monoaldehyde
initial amount: NaN
is: CHEBI:30623
constant: false
type: Species
boundary condition: false
notes: FORMULA: C10H26N3O CHARGE: 3 INCHI: InChI=1/C10H23N3O/c11-5-3-8-12-6-1-2-7-13-9-4-10-14/h10,12-13H,1-9,11H2/p+3 EHMN_ABBREVIATION: CE1935

W3 CDTF: Thu Aug 30 00:04:43 BST 2012

metaM fad e
type: Species
name: Flavin adenine dinucleotide oxidized
initial concentration: 1.0
notes: FORMULA: C27H31N9O15P2 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00026 EHMN_ABBREVIATION: C00016
is: HMDB01248
boundary condition: false
is: C00016
initial amount: NaN
is: CHEBI:16238
is: SBO:0000247
has only substance units: false
constant: false

metaM xan c
constant: false
is: CHEBI:17712
notes: FORMULA: C5H4N4O2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00320 EHMN_ABBREVIATION: C00385
is: HMDB00292
boundary condition: false
initial amount: NaN
is: C00385
type: Species
is: SBO:0000247
name: Xanthine
has only substance units: false
initial concentration: 1.0

metaR DMNONCRNt
product: MODEL1310110063#
is: SBO:0000185
reactant: MODEL1310110063#
name: 4,8 dimethylnonanoyl carnitine transport (mitochondria)
kinetic law: MODEL1310110063#
fast: false
reversible: true
type: Reaction
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 2 AUTHORS: PMID:9299016,PMID:9819701 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110063#_04313f1b_1476_4f2d_a8d3_31e92d857f64
type: Species
has only substance units: false
name: ECI2
initial concentration: NaN
initial amount: NaN
constant: false
is: SBO:0000252
is: O75521
is encoded by: hsa:10455
boundary condition: true

metaR UMPK3n
fast: false
product: MODEL1310110063#
is version of: http://identifiers.org/ec-code/2.7.4.14
is described by: ECO:0000269
is: SBO:0000176
reversible: true
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
name: UMP kinase (UTP),nuclear
reactant: MODEL1310110063#
kinetic law: MODEL1310110063#
type: Reaction
modifier: MODEL1310110063#

http://identifiers.org/biomodels.db/MODEL1310110063#_c4650309_1619_4eca_9e8e_aeaefeb0bec6
is encoded by: hsa:5092
has only substance units: false
name: PCBD1
boundary condition: true
is: SBO:0000252
constant: false
initial concentration: NaN
initial amount: NaN
type: Species

metaM icit x
is: SBO:0000247
has only substance units: false
initial amount: NaN
constant: false
notes: FORMULA: C6H5O7 CHARGE: -3 INCHI: InChI=1S/C6H8O7/c7-3(8)1-2(5(10)11)4(9)6(12)13/h2,4,9H,1H2,(H,7,8)(H,10,11)(H,12,13)/p-3 HEPATONET_1.0_ABBREVIATION: HC00266 EHMN_ABBREVIATION: C00311
boundary condition: false
is: HMDB00193
initial concentration: 1.0
is: CHEBI:16087
type: Species
name: isocitrate(3-)

metaR r2521
type: Reaction
reactant: MODEL1310110063#
fast: false
reversible: true
kinetic law: MODEL1310110063#
name: Utilized transport
product: MODEL1310110063#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:8691743 NOTES:
is described by: ECO:0000000
is: SBO:0000185

metaR EX rbt LPAREN e RPAREN
kinetic law: MODEL1310110063#
reactant: MODEL1310110063#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Ribitol exchange
type: Reaction

metaR PCt
kinetic law: MODEL1310110063#
notes: GENE_ASSOCIATION: (5244.1) or (5244.3) or (5244.2) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:11826283,PMID:7912658 NOTES:for PC secretion into bile NJ
modifier: MODEL1310110063#
name: phosphatidylcholine transporter
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/3.6.3.44
fast: false
is: SBO:0000185
type: Reaction
reactant: MODEL1310110063#
reversible: true
product: MODEL1310110063#

metaR EX HC01609 LPAREN e RPAREN
kinetic law: MODEL1310110063#
reactant: MODEL1310110063#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of UroporphyrinogenI
type: Reaction

metaM na1 e
is: C01330
boundary condition: false
type: Species
name: Sodium
is: HMDB00588
is: CHEBI:4541
constant: false
has only substance units: false
initial concentration: 1.0
initial amount: NaN
is: SBO:0000247
notes: FORMULA: Na CHARGE: 1

metaR GALASE18ly
is version of: http://identifiers.org/ec-code/3.4.16.5
is version of: http://identifiers.org/ec-code/3.2.1.18
is version of: http://identifiers.org/ec-code/3.1.6.4
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) or (5476.1) and (2720.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.23 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD
name: beta-galactosidase, lysosomal
is version of: http://identifiers.org/ec-code/3.2.1.23
fast: false
is: SBO:0000176
reversible: false
product: MODEL1310110063#
reactant: MODEL1310110063#
type: Reaction
kinetic law: MODEL1310110063#
is described by: ECO:0000000
modifier: MODEL1310110063#

W3 CDTF: Thu Aug 30 00:04:43 BST 2012

metaR RE2079R
is described by: ECO:0000000
name: RE2079
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Eicosanoid metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:10200320,PMID:11786541,PMID:8521498,PMID:9755286 NOTES:
kinetic law: MODEL1310110063#
reactant: MODEL1310110063#
type: Reaction
product: MODEL1310110063#
is: SBO:0000176
reversible: true

metaR EX tdchola LPAREN e RPAREN
kinetic law: MODEL1310110063#
reactant: MODEL1310110063#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: taurochenodeoxycholate exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110063#_efae357f_5588_4e59_9b2c_e7785698e58a
is: A8K596
is: SBO:0000252
is encoded by: hsa:1757
boundary condition: true
has only substance units: false
name: SARDH
initial amount: NaN
constant: false
initial concentration: NaN
type: Species

http://identifiers.org/biomodels.db/MODEL1310110063#_c38a82f4_4e3a_4d29_b3d5_43f8b43fe726
constant: false
initial concentration: NaN
has only substance units: false
is encoded by: hsa:570
initial amount: NaN
type: Species
is: SBO:0000252
is: Q14032
name: BAAT
boundary condition: true

metaM hdcea r
is: CHEBI:32372
initial amount: NaN
has only substance units: false
boundary condition: false
notes: FORMULA: C16H29O2 CHARGE: -1 INCHI: InChI=1S/C16H30O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16(17)18/h7-8H,2-6,9-15H2,1H3,(H,17,18)/p-1/b8-7- HEPATONET_1.0_ABBREVIATION: HC01981 EHMN_ABBREVIATION: CE0850
is: HMDB03229
type: Species
initial concentration: 1.0
is: SBO:0000247
name: palmitoleate
constant: false

metaR EX gal LPAREN e RPAREN
kinetic law: MODEL1310110063#
reactant: MODEL1310110063#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for D-Galactose
type: Reaction

metaR FAOXC164x
kinetic law: MODEL1310110063#
product: MODEL1310110063#
reactant: MODEL1310110063#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: isomerization(C16:4)x
type: Reaction

metaR r0202
notes: GENE_ASSOCIATION: SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: 1.1.1.8 Confidence Level: 0 AUTHORS: PMID:17045662,PMID:7772607 NOTES:
is described by: ECO:0000000
fast: false
type: Reaction
kinetic law: MODEL1310110063#
product: MODEL1310110063#
reversible: true
name: sn-Glycerol-3-phosphate:NAD+ 2-oxidoreductase Glycerophospholipid metabolism EC:1.1.1.8
is: SBO:0000176
reactant: MODEL1310110063#

metaR C30CPT1
kinetic law: MODEL1310110063#
product: MODEL1310110063#
reactant: MODEL1310110063#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: production of propionylcarnitine
type: Reaction

metaR EX dhf LPAREN e RPAREN
kinetic law: MODEL1310110063#
reactant: MODEL1310110063#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 7,8-Dihydrofolate exchange
type: Reaction

metaM fadh2 c
name: FADH2(2-)
type: Species
initial amount: NaN
boundary condition: false
constant: false
initial concentration: 1.0
is: SBO:0000247
notes: FORMULA: C27H33N9O15P2 CHARGE: -2 INCHI: InChI=1S/C27H35N9O15P2/c1-10-3-12-13(4-11(10)2)35(24-18(32-12)25(42)34-27(43)33-24)5-14(37)19(39)15(38)6-48-52(44,45)51-53(46,47)49-7-16-20(40)21(41)26(50-16)36-9-31-17-22(28)29-8-30-23(17)36/h3-4,8-9,14-16,19-21,26,32,37-41H,5-7H2,1-2H3,(H,44,45)(H,46,47)(H2,28,29,30)(H2,33,34,42,43)/p-2/t14-,15+,16+,19-,20+,21+,26+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00770 EHMN_ABBREVIATION: C01352
is: CHEBI:58307
is: HMDB01197
has only substance units: false

metaR GCC2am
notes: GENE_ASSOCIATION: (275.1) and (1738.1) and (2731.1) and (2653.1) SUBSYSTEM: Glycine, serine, alanine and threonine metabolism EC Number: 2.1.2.10 Confidence Level: 4 AUTHORS: PMID:15355973 NOTES:NCD
product: MODEL1310110063#
is: SBO:0000176
name: glycine-cleavage complex (lipoamide), mitochondrial
modifier: MODEL1310110063#
is version of: http://identifiers.org/ec-code/1.8.1.4
type: Reaction
fast: false
is version of: http://identifiers.org/ec-code/1.4.4.2
reactant: MODEL1310110063#
reversible: true
kinetic law: MODEL1310110063#
is version of: http://identifiers.org/ec-code/2.1.2.10
is described by: ECO:0000269

metaM m7masnB g
name: (alpha-D-mannosyl)7-beta-D-mannosyl-diacetylchitobiosyl-L-asparagine, isoform B (protein)
is: C05881
is: SBO:0000247
constant: false
boundary condition: false
initial concentration: 1.0
type: Species
notes: FORMULA: C64H107N2O50X CHARGE: 0
initial amount: NaN
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110063#_1e2ee698_1e42_4b52_a0f0_83e98b20caa5
type: Species
is encoded by: hsa:10861
initial concentration: NaN
name: SLC26A1
initial amount: NaN
has only substance units: false
constant: false
boundary condition: true
is: SBO:0000252
is: Q9H2B4

http://identifiers.org/biomodels.db/MODEL1310110063#_562ffaf4_6a61_48c7_bfb7_84137def074b
is: SBO:0000252
initial concentration: NaN
constant: false
initial amount: NaN
is encoded by: hsa:5139
type: Species
has only substance units: false
is: Q14432
boundary condition: true
name: PDE3A

http://identifiers.org/biomodels.db/MODEL1310110063#_3f16f4ef_89e3_4b0d_a2bc_11b0821eb371
type: Species
is: Q308M7
name: ENPP3
boundary condition: true
is encoded by: hsa:5169
constant: false
has only substance units: false
is: SBO:0000252
initial amount: NaN
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110063#_158e6827_7d01_4dac_950a_7794e26f54ad
initial amount: NaN
initial concentration: NaN
constant: false
has only substance units: false
is encoded by: hsa:1350
type: Species
is: SBO:0000252
is: P15954
name: COX7C
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110063#_f26c16ee_e5ae_4933_bebd_2bfa3c8cbc97
boundary condition: true
is encoded by: hsa:114112
type: Species
name: TXNRD3
initial amount: NaN
constant: false
initial concentration: NaN
is: Q86VQ6
has only substance units: false
is: SBO:0000252

metaM pcrn m
initial amount: NaN
is: SBO:0000247
is: HMDB00824
constant: false
has only substance units: false
name: propionyl-carnitine
is: http://identifiers.org/pubchem.compound/107738
type: Species
initial concentration: 1.0
boundary condition: false
notes: FORMULA: C10H19NO4 CHARGE: 0 INCHI: InChI=1/C10H19NO4/c1-5-10(14)15-8(6-9(12)13)7-11(2,3)4/h8H,5-7H2,1-4H3

http://identifiers.org/biomodels.db/MODEL1310110063#_e26be2a6_c23d_448b_93b6_0c5da556c6f9
is encoded by: hsa:1629
initial concentration: NaN
name: DBT
constant: false
initial amount: NaN
is: SBO:0000252
type: Species
boundary condition: true
has only substance units: false
is: P11182

http://identifiers.org/biomodels.db/MODEL1310110063#_b3ff692b_0e71_4fb3_ac2a_04b4f469ee0e
initial amount: NaN
has part: P16499
is encoded by: hsa:5158
is encoded by: hsa:5149
is: SBO:0000297
is encoded by: hsa:5145
boundary condition: true
initial concentration: NaN
type: Species
name: PDE6A:PDE6H:PDE6B
has only substance units: false
has part: Q13956
has part: B7Z9T9
constant: false

metaR EX sbt DASH d LPAREN e RPAREN
kinetic law: MODEL1310110063#
reactant: MODEL1310110063#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for D-Sorbitol
type: Reaction

metaM pail35p hs c
initial amount: NaN
is: SBO:0000247
constant: false
name: 1-phosphatidyl-1D-myo-inositol 3,5-bisphosphate(5-)
is: CHEBI:57923
has only substance units: false
type: Species
initial concentration: 1.0
boundary condition: false
notes: FORMULA: C9H14O15P3FULLRCO2FULLR2CO2 CHARGE: -5

metaR SIAASE2ly
reversible: false
is version of: http://identifiers.org/ec-code/3.4.16.5
type: Reaction
kinetic law: MODEL1310110063#
is version of: http://identifiers.org/ec-code/3.2.1.18
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.18 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD
product: MODEL1310110063#
is version of: http://identifiers.org/ec-code/3.2.1.23
is version of: http://identifiers.org/ec-code/3.1.6.4
fast: false
reactant: MODEL1310110063#
is described by: ECO:0000000
is: SBO:0000176
modifier: MODEL1310110063#
name: sialidase, lysosomal

http://identifiers.org/biomodels.db/MODEL1310110063#_6b0df96b_e8ce_44f0_b7ae_4c21c4bbcab3
initial amount: NaN
constant: false
type: Species
is: Q13956
is encoded by: hsa:5149
has only substance units: false
boundary condition: true
initial concentration: NaN
is: SBO:0000252
name: PDE6H

http://identifiers.org/biomodels.db/MODEL1310110063#_8e58b0c0_c690_45b6_a23a_28876896c3c0
is: SBO:0000252
name: GCK
boundary condition: true
is encoded by: hsa:2645
type: Species
constant: false
has only substance units: false
initial amount: NaN
is: P35557
initial concentration: NaN

metaM na1 c
constant: false
name: Sodium
is: CHEBI:4541
is: SBO:0000247
boundary condition: false
initial concentration: 1.0
has only substance units: false
is: C01330
type: Species
initial amount: NaN
notes: FORMULA: Na CHARGE: 1
is: HMDB00588

metaM eicostet c
type: Species
is: CHEBI:36033
initial amount: NaN
has only substance units: false
is: SBO:0000247
boundary condition: false
initial concentration: 1.0
notes: FORMULA: C20H31O2 CHARGE: -1
constant: false
is: HMDB02177
name: eicosatetranoic acid

metaR r1443
reactant: MODEL1310110063#
reversible: false
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 0 AUTHORS: PMID:17603022,PMID:6240978,PMID:7876265 NOTES:
kinetic law: MODEL1310110063#
is: SBO:0000176
product: MODEL1310110063#
type: Reaction
fast: false
name: EC:1.3.3.6

metaM acrn m
initial amount: NaN
is: SBO:0000247
is: HMDB00201
boundary condition: false
is: CHEBI:57589
name: O-acetylcarnitine
initial concentration: 1.0
constant: false
type: Species
has only substance units: false
notes: FORMULA: C9H17NO4 CHARGE: 0 INCHI: InChI=1S/C9H17NO4/c1-7(11)14-8(5-9(12)13)6-10(2,3)4/h8H,5-6H2,1-4H3/t8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00966 EHMN_ABBREVIATION: C02571

http://identifiers.org/biomodels.db/MODEL1310110063#_5ab7ff7b_f36a_4022_9789_f85a931b3112
name: COX2
initial concentration: NaN
boundary condition: true
has only substance units: false
type: Species
is: Q7GXZ8
constant: false
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:4513

metaR RBTt
type: Reaction
is: SBO:0000185
kinetic law: MODEL1310110063#
name: ribitol transport via passive diffusion
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:15234337 NOTES:NCD
reactant: MODEL1310110063#
fast: false
product: MODEL1310110063#
reversible: false

metaM dolmanp U c
is: CHEBI:15809
initial concentration: 1.0
boundary condition: false
constant: false
initial amount: NaN
type: Species
notes: FORMULA: C1085H1780O90P10 CHARGE: -10 INCHI: InChI=1S/C31H55O9P/c1-22(2)11-7-12-23(3)13-8-14-24(4)15-9-16-25(5)17-10-18-26(6)19-20-38-41(36,37)40-31-30(35)29(34)28(33)27(21-32)39-31/h11,13,15,17,26-35H,7-10,12,14,16,18-21H2,1-6H3,(H,36,37)/b23-13+,24-15+,25-17-/t26?,27-,28-,29+,30+,31?/m1/s1
has only substance units: false
is: SBO:0000247
name: Dolichyl phosphate D-mannose, human uterine homolog

metaM oaa c
constant: false
boundary condition: false
initial amount: NaN
notes: FORMULA: C4H2O5 CHARGE: -2
name: Oxaloacetate
is: SBO:0000247
initial concentration: 1.0
has only substance units: false
is: CHEBI:3338
is: C00036
type: Species
is: HMDB00223

metaM dcdp m
type: Species
is: HMDB01245
is: CHEBI:58593
is: SBO:0000247
boundary condition: false
notes: FORMULA: C9H12N3O10P2 CHARGE: -3 INCHI: InChI=1S/C9H15N3O10P2/c10-7-1-2-12(9(14)11-7)8-3-5(13)6(21-8)4-20-24(18,19)22-23(15,16)17/h1-2,5-6,8,13H,3-4H2,(H,18,19)(H2,10,11,14)(H2,15,16,17)/p-3/t5-,6+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00506 EHMN_ABBREVIATION: C00705
name: dCDP(3-)
constant: false
initial concentration: 1.0
initial amount: NaN
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110063#_1dbb141b_1909_4385_a6a8_19694340b5eb
type: Species
has only substance units: false
name: GALE
is: Q14376
boundary condition: true
constant: false
initial amount: NaN
is: SBO:0000252
is encoded by: hsa:2582
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110063#_50a4eb00_7565_4e01_8328_ca09753f5817
constant: false
boundary condition: true
initial amount: NaN
type: Species
is encoded by: hsa:197257
initial concentration: NaN
has only substance units: false
name: LDHD
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110063#_365d6c9d_e6b6_4b23_940b_23561088417c
is: SBO:0000252
is encoded by: hsa:10449
boundary condition: true
type: Species
has only substance units: false
constant: false
initial amount: NaN
is: P42765
name: ACAA2
initial concentration: NaN

metaR r2525
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:10049700,PMID:10574970,PMID:11389679,PMID:11557028,PMID:11564694,PMID:12824232,PMID:12930836,PMID:14574404,PMID:16288981,PMID:911815 NOTES:
fast: false
kinetic law: MODEL1310110063#
is: SBO:0000185
product: MODEL1310110063#
is described by: ECO:0000000
name: Major Facilitator(MFS) TCDB:2.A.1.44.1
reactant: MODEL1310110063#
type: Reaction
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110063#_d6ca880d_ed23_4ad7_b0e5_3c9916626f0c
is: SBO:0000252
is: O14556
type: Species
initial amount: NaN
is encoded by: hsa:26330
constant: false
initial concentration: NaN
name: GAPDHS
has only substance units: false
boundary condition: true

metaR AG13T13g
kinetic law: MODEL1310110063#
modifier: MODEL1310110063#
is version of: http://identifiers.org/ec-code/2.4.1.149
reactant: MODEL1310110063#
is described by: ECO:0000000
type: Reaction
name: N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase, Golgi apparatus
fast: false
notes: GENE_ASSOCIATION: (79369.1) or (374907.1) or (11041.1) or (146712.1) or (374907.2) or (93010.1) or (10331.1) or (10678.1) or (10678.2) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.149 Confidence Level: 4 AUTHORS: PMID:10747980,PMID:11042166,PMID:12061784,PMID:12512857,PMID:15560372,PMID:15620693,PMID:9405606 NOTES:NCD
product: MODEL1310110063#
reversible: false
is: SBO:0000176

metaR EX strdnc LPAREN e RPAREN
kinetic law: MODEL1310110063#
reactant: MODEL1310110063#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: stearidonic acid exchange
type: Reaction

metaR ASNALANaEx
is: SBO:0000185
name: L-alanine/L-asparagine Na-dependent exchange (Asn-L in)
reactant: MODEL1310110063#
kinetic law: MODEL1310110063#
modifier: MODEL1310110063#
fast: false
reversible: false
notes: GENE_ASSOCIATION: (6510.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14530974 NOTES:SAB see Kanai and Hediger 2004 (2003), PMID 14530974
is described by: ECO:0000269
product: MODEL1310110063#
type: Reaction

metaR r2526
reactant: MODEL1310110063#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:10049700,PMID:10574970,PMID:11389679,PMID:11557028,PMID:11564694,PMID:12824232,PMID:12930836,PMID:14574404,PMID:16288981,PMID:911815 NOTES:
is described by: ECO:0000000
name: Major Facilitator(MFS) TCDB:2.A.1.44.1
type: Reaction
fast: false
reversible: true
is: SBO:0000185
product: MODEL1310110063#
kinetic law: MODEL1310110063#

metaR GCC2bim
fast: false
is version of: http://identifiers.org/ec-code/2.1.2.10
type: Reaction
reversible: false
kinetic law: MODEL1310110063#
is: SBO:0000176
modifier: MODEL1310110063#
notes: GENE_ASSOCIATION: (275.1) and (1738.1) and (2731.1) and (2653.1) SUBSYSTEM: Glycine, serine, alanine and threonine metabolism EC Number: 1.8.1.4 Confidence Level: 4 AUTHORS: PMID:15355973 NOTES:NCD
product: MODEL1310110063#
reactant: MODEL1310110063#
is version of: http://identifiers.org/ec-code/1.8.1.4
name: glycine-cleavage system (lipoamide) irreversible, mitochondrial
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/1.4.4.2

metaM sphings c
is: CHEBI:57756
is: HMDB00252
initial amount: NaN
name: sphingosine(1+)
constant: false
type: Species
boundary condition: false
initial concentration: 1.0
notes: FORMULA: C18H38NO2 CHARGE: 1 INCHI: InChI=1S/C18H37NO2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-18(21)17(19)16-20/h14-15,17-18,20-21H,2-13,16,19H2,1H3/p+1/b15-14+/t17-,18+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00271 EHMN_ABBREVIATION: C00319
has only substance units: false
is: SBO:0000247

metaR ALR3
fast: false
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/1.1.1.21
reversible: false
type: Reaction
product: MODEL1310110063#
is: SBO:0000176
reactant: MODEL1310110063#
modifier: MODEL1310110063#
notes: GENE_ASSOCIATION: (10327.2) or (8574.1) or (10327.1) or (231.1) SUBSYSTEM: Pyruvate metabolism EC Number: 1.1.1.21 Confidence Level: 4 AUTHORS: PMID:12071861,PMID:1537826,PMID:9823300 NOTES:NCD
name: aldose reductase (acetol)
kinetic law: MODEL1310110063#
is version of: http://identifiers.org/ec-code/1.1.1.2

http://identifiers.org/biomodels.db/MODEL1310110063#_b9ea22d2_a464_473f_9a22_bab32b94be18
is: SBO:0000252
type: Species
name: SLC13A5
boundary condition: true
initial amount: NaN
is: Q86YT5
has only substance units: false
initial concentration: NaN
is encoded by: hsa:284111
constant: false

metaM pa hs m
initial amount: NaN
has only substance units: false
is: CHEBI:57739
initial concentration: 1.0
notes: FORMULA: C3H5O4PFULLRCO2FULLR2CO2 CHARGE: -2 EHMN_ABBREVIATION: C00416
is: SBO:0000247
constant: false
name: phosphatidate(2-)
boundary condition: false
type: Species

metaM gthox m
is: CHEBI:58297
boundary condition: false
is: SBO:0000247
constant: false
notes: FORMULA: C20H30N6O12S2 CHARGE: -2 INCHI: InChI=1S/C20H32N6O12S2/c21-9(19(35)36)1-3-13(27)25-11(17(33)23-5-15(29)30)7-39-40-8-12(18(34)24-6-16(31)32)26-14(28)4-2-10(22)20(37)38/h9-12H,1-8,21-22H2,(H,23,33)(H,24,34)(H,25,27)(H,26,28)(H,29,30)(H,31,32)(H,35,36)(H,37,38)/p-2/t9-,10-,11-,12-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00125 EHMN_ABBREVIATION: C00127
initial amount: NaN
type: Species
is: HMDB03337
has only substance units: false
initial concentration: 1.0

metaR IDOAASE4ly
fast: false
product: MODEL1310110063#
reactant: MODEL1310110063#
is: SBO:0000176
notes: GENE_ASSOCIATION: (3425.1) SUBSYSTEM: Chondroitin sulfate degradation EC Number: 3.2.1.76 Confidence Level: 4 AUTHORS: PMID:1946389,PMID:2470345 NOTES:NCD
is described by: ECO:0000000
reversible: false
is version of: http://identifiers.org/ec-code/3.2.1.76
modifier: MODEL1310110063#
type: Reaction
name: alpha-L-iduronidase, lysosomal
kinetic law: MODEL1310110063#

metaM m4masn g
boundary condition: false
initial concentration: 1.0
name: (alpha-D-mannosyl)4-beta-D-mannosyl-diacetylchitobiosyl-L-asparagine (protein)
type: Species
initial amount: NaN
constant: false
has only substance units: false
notes: FORMULA: C46H77N2O35X CHARGE: 0
is: SBO:0000247
is: C05881

metaM fad c
initial concentration: 1.0
name: Flavin adenine dinucleotide oxidized
notes: FORMULA: C27H31N9O15P2 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00026 EHMN_ABBREVIATION: C00016
has only substance units: false
is: SBO:0000247
constant: false
boundary condition: false
initial amount: NaN
is: HMDB01248
type: Species
is: CHEBI:16238
is: C00016

metaR GLCAASE8ly
is: SBO:0000176
kinetic law: MODEL1310110063#
modifier: MODEL1310110063#
type: Reaction
fast: false
is described by: ECO:0000269
product: MODEL1310110063#
reactant: MODEL1310110063#
name: beta-glucuronidase, lysosomal
reversible: false
is version of: http://identifiers.org/ec-code/3.2.1.31
notes: GENE_ASSOCIATION: (2990.1) SUBSYSTEM: Hyaluronan metabolism EC Number: 3.2.1.31 Confidence Level: 4 AUTHORS: PMID:3468507,PMID:3924735,PMID:3987656 NOTES:NCD

metaM retn e
is: CHEBI:35291
notes: FORMULA: C20H27O2 CHARGE: -1 INCHI: InChI=1S/C20H28O2/c1-15(8-6-9-16(2)14-19(21)22)11-12-18-17(3)10-7-13-20(18,4)5/h6,8-9,11-12,14H,7,10,13H2,1-5H3,(H,21,22)/p-1/b9-6+,12-11+,15-8+,16-14+ HEPATONET_1.0_ABBREVIATION: HC00532 EHMN_ABBREVIATION: C00777
is: SBO:0000247
constant: false
initial concentration: 1.0
has only substance units: false
is: HMDB01852
name: all-trans-retinoate
initial amount: NaN
boundary condition: false
type: Species

metaM mpdol U c
notes: FORMULA: C1245H2040N20O220P20 CHARGE: -20
has only substance units: false
is: CHEBI:18396
boundary condition: false
name: beta-D-Mannosyldiacetylchitobiosyldiphosphodolichol, human uterine homolog
type: Species
is: SBO:0000247
initial concentration: 1.0
constant: false
initial amount: NaN

metaM bilglcur e
initial amount: NaN
name: mono(glucosyluronic acid)bilirubin(2-)
is: SBO:0000247
has only substance units: false
initial concentration: 1.0
notes: FORMULA: C39H44N4O12 CHARGE: 0 INCHI: InChI=1S/C39H44N4O12/c1-7-20-19(6)36(50)43-27(20)14-25-18(5)23(10-12-31(46)54-39-34(49)32(47)33(48)35(55-39)38(52)53)29(41-25)15-28-22(9-11-30(44)45)17(4)24(40-28)13-26-16(3)21(8-2)37(51)42-26/h7-8,13-14,32-35,39-41,47-49H,1-2,9-12,15H2,3-6H3,(H,42,51)(H,43,50)(H,44,45)(H,52,53)/p-2/b26-13+,27-14+/t32-,33-,34+,35-,39+/m0/s1 EHMN_ABBREVIATION: C03374
is: CHEBI:57767
type: Species
boundary condition: false
constant: false

metaR CORE2GTg
product: MODEL1310110063#
modifier: MODEL1310110063#
notes: GENE_ASSOCIATION: (9245.1) or (2650.1) or (51301.1) SUBSYSTEM: O-glycan synthesis EC Number: 2.4.1.102 Confidence Level: 0 AUTHORS: PMID:10753916,PMID:9915862 NOTES:NCD
name: Core 2 acetylglucosaminyltransferase, Golgi apparatus
is version of: http://identifiers.org/ec-code/2.4.1.102
is described by: ECO:0000000
kinetic law: MODEL1310110063#
reversible: false
fast: false
type: Reaction
is: SBO:0000176
reactant: MODEL1310110063#

metaR r1446
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 1.3.3.6 Confidence Level: 0 AUTHORS: PMID:17603022,PMID:1774065,PMID:3597357,PMID:6240978,PMID:7876265 NOTES:
reversible: false
reactant: MODEL1310110063#
type: Reaction
fast: false
product: MODEL1310110063#
kinetic law: MODEL1310110063#
is described by: ECO:0000000
name: EC:1.3.3.6
is: SBO:0000176

metaR ACt2m
kinetic law: MODEL1310110063#
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: PMID:10198029,PMID:15755952 NOTES:NCD
is described by: ECO:0000000
product: MODEL1310110063#
is: SBO:0000185
reactant: MODEL1310110063#
type: Reaction
fast: false
name: acetate mitochondrial transport via proton symport

metaM bilglcur c
notes: FORMULA: C39H44N4O12 CHARGE: 0 INCHI: InChI=1S/C39H44N4O12/c1-7-20-19(6)36(50)43-27(20)14-25-18(5)23(10-12-31(46)54-39-34(49)32(47)33(48)35(55-39)38(52)53)29(41-25)15-28-22(9-11-30(44)45)17(4)24(40-28)13-26-16(3)21(8-2)37(51)42-26/h7-8,13-14,32-35,39-41,47-49H,1-2,9-12,15H2,3-6H3,(H,42,51)(H,43,50)(H,44,45)(H,52,53)/p-2/b26-13+,27-14+/t32-,33-,34+,35-,39+/m0/s1 EHMN_ABBREVIATION: C03374
initial amount: NaN
has only substance units: false
constant: false
is: SBO:0000247
boundary condition: false
initial concentration: 1.0
is: CHEBI:57767
type: Species
name: mono(glucosyluronic acid)bilirubin(2-)

metaR XYLTD Dr
is: SBO:0000176
reversible: true
fast: false
product: MODEL1310110063#
kinetic law: MODEL1310110063#
name: xylitol dehydrogenase (D-xyulose-forming)
reactant: MODEL1310110063#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Pentose phosphate pathway EC Number: 1.1.1.9 Confidence Level: 2 AUTHORS: PMID:6821187 NOTES:
is described by: ECO:0000000

metaM ksi deg36 l
notes: FORMULA: C62H103N4O49S1 CHARGE: -1
is: CHEBI:12936
initial amount: NaN
initial concentration: 1.0
boundary condition: false
constant: false
name: keratan sulfate I, degradation product 36
is: HMDB00143
has only substance units: false
type: Species
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110063#_9a1764e1_2a1c_447c_95e2_7105ecf8a85a
boundary condition: true
initial amount: NaN
type: Species
is encoded by: hsa:5289
name: PIK3C3
is: Q8NEB9
constant: false
has only substance units: false
initial concentration: NaN
is: SBO:0000252

metaR ALR2
kinetic law: MODEL1310110063#
is version of: http://identifiers.org/ec-code/1.1.1.2
fast: false
is described by: ECO:0000269
type: Reaction
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.1.1.21
modifier: MODEL1310110063#
notes: GENE_ASSOCIATION: (10327.2) or (8574.1) or (10327.1) or (231.1) SUBSYSTEM: Pyruvate metabolism EC Number: 1.1.1.21 Confidence Level: 4 AUTHORS: PMID:12071861,PMID:1537826,PMID:9823300 NOTES:NCD
reversible: false
product: MODEL1310110063#
reactant: MODEL1310110063#
name: aldose reductase (methylglyoxal)

metaR 4MOPte
product: MODEL1310110063#
name: Transport of 4-methyl-2-oxopentanoate
reversible: true
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
type: Reaction
reactant: MODEL1310110063#
is: SBO:0000185
kinetic law: MODEL1310110063#
is described by: ECO:0000134

http://identifiers.org/biomodels.db/MODEL1310110063#_5d95a19a_1dfe_4987_8c2e_919672ef7e4a
boundary condition: true
initial amount: NaN
is: SBO:0000252
is encoded by: hsa:11226
type: Species
name: GALNT6
initial concentration: NaN
is: Q8NCL4
has only substance units: false
constant: false

metaR ACETONEt2
fast: false
name: acetone transport via proton symport
reactant: MODEL1310110063#
is: SBO:0000185
modifier: MODEL1310110063#
kinetic law: MODEL1310110063#
type: Reaction
reversible: true
notes: GENE_ASSOCIATION: (6566.1) or (9123.1) or (9194.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10510291,PMID:11101640,PMID:12739169,PMID:7835905,PMID:8476015,PMID:9425115,PMID:9508842,PMID:9649795,PMID:9786900,PMID:9824713 NOTES:NCD
is described by: ECO:0000269
product: MODEL1310110063#

metaM lnlncgcoa m
boundary condition: false
is: HMDB06368
has only substance units: false
initial concentration: 1.0
is: CHEBI:57363
initial amount: NaN
constant: false
type: Species
notes: FORMULA: C39H60N7O17P3S CHARGE: -4 INCHI: InChI=1S/C39H64N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-30(48)67-23-22-41-29(47)20-21-42-37(51)34(50)39(2,3)25-60-66(57,58)63-65(55,56)59-24-28-33(62-64(52,53)54)32(49)38(61-28)46-27-45-31-35(40)43-26-44-36(31)46/h8-9,11-12,14-15,26-28,32-34,38,49-50H,4-7,10,13,16-25H2,1-3H3,(H,41,47)(H,42,51)(H,55,56)(H,57,58)(H2,40,43,44)(H2,52,53,54)/p-4/b9-8-,12-11-,15-14-/t28-,32-,33-,34+,38-/m1/s1 EHMN_ABBREVIATION: C03035
is: SBO:0000247
name: gamma-linolenoyl-CoA(4-)

metaR r0081
is described by: ECO:0000000
modifier: MODEL1310110063#
reversible: true
fast: false
notes: GENE_ASSOCIATION: (8659.1) SUBSYSTEM: Citric acid cycle EC Number: 2.6.1.2 Confidence Level: 0 AUTHORS: PMID:15663181,PMID:2088925,PMID:454616 NOTES:
kinetic law: MODEL1310110063#
product: MODEL1310110063#
name: L-Alanine:2-oxoglutarate aminotransferase Glutamate metabolism / Alanine and aspartate metabolism EC:2.6.1.2
type: Reaction
reactant: MODEL1310110063#
is version of: http://identifiers.org/ec-code/1.5.1.12
is: SBO:0000176

metaM CE5114 x
constant: false
notes: FORMULA: C41H62N7O17P3S CHARGE: -4 INCHI: InChI=1/C41H66N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-32(50)69-25-24-43-31(49)22-23-44-39(53)36(52)41(2,3)27-62-68(59,60)65-67(57,58)61-26-30-35(64-66(54,55)56)34(51)40(63-30)48-29-47-33-37(42)45-28-46-38(33)48/h8-9,11-12,14-15,20-21,28-30,34-36,40,51-52H,4-7,10,13,16-19,22-27H2,1-3H3,(H,43,49)(H,44,53)(H,57,58)(H,59,60)(H2,42,45,46)(H2,54,55,56)/p-4/b9-8-,12-11-,15-14-,21-20+/t30-,34+,35+,36u,40-/m0/s1 EHMN_ABBREVIATION: CE5114
type: Species
is: CHEBI:57923
initial concentration: 1.0
boundary condition: false
name: trans-2-cis,cis,cis-8,11,14-eicosatetraenoyl-CoA
has only substance units: false
initial amount: NaN
is: SBO:0000247

metaR SO4OXAtex2
reactant: MODEL1310110063#
product: MODEL1310110063#
is described by: ECO:0000304
kinetic law: MODEL1310110063#
fast: false
reversible: false
type: Reaction
name: sulfate transport via oxalate countertransport (2:1)
modifier: MODEL1310110063#
is: SBO:0000185
notes: GENE_ASSOCIATION: (65010.1) or (65010.3) or (65010.2) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:12759755 NOTES:SAB

metaR r0084
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.1.1.42
reversible: true
fast: false
is described by: ECO:0000000
modifier: MODEL1310110063#
reactant: MODEL1310110063#
kinetic law: MODEL1310110063#
product: MODEL1310110063#
type: Reaction
notes: GENE_ASSOCIATION: (AI971036.1) or (3417.1) or (3418.1) SUBSYSTEM: Unassigned EC Number: 1.1.1.42 Confidence Level: 0 AUTHORS: PMID:16489927,PMID:9866202 NOTES:
name: Oxalosuccinate:NADP+ oxidoreductase (decarboxylating) Citrate cycle (TCA cycle) EC:1.1.1.42

metaR FAOXC164m
kinetic law: MODEL1310110063#
product: MODEL1310110063#
reactant: MODEL1310110063#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: isomerization(C16:4)m
type: Reaction

metaR GLUPRT
reversible: false
name: glutamine phosphoribosyldiphosphate amidotransferase
is version of: http://identifiers.org/ec-code/2.4.2.14
modifier: MODEL1310110063#
is: SBO:0000176
notes: GENE_ASSOCIATION: (5471.1) SUBSYSTEM: Purine synthesis EC Number: 2.4.2.14 Confidence Level: 4 AUTHORS: PMID:8106516,PMID:8380692,PMID:9108165 NOTES:
fast: false
is described by: ECO:0000269
type: Reaction
kinetic law: MODEL1310110063#
product: MODEL1310110063#
reactant: MODEL1310110063#

metaM retn c
notes: FORMULA: C20H27O2 CHARGE: -1 INCHI: InChI=1S/C20H28O2/c1-15(8-6-9-16(2)14-19(21)22)11-12-18-17(3)10-7-13-20(18,4)5/h6,8-9,11-12,14H,7,10,13H2,1-5H3,(H,21,22)/p-1/b9-6+,12-11+,15-8+,16-14+ HEPATONET_1.0_ABBREVIATION: HC00532 EHMN_ABBREVIATION: C00777
is: HMDB01852
initial concentration: 1.0
is: CHEBI:35291
is: SBO:0000247
type: Species
boundary condition: false
constant: false
initial amount: NaN
name: all-trans-retinoate
has only substance units: false

metaR ORNTArm
type: Reaction
notes: GENE_ASSOCIATION: (4942.1) SUBSYSTEM: Urea cycle EC Number: 2.6.1.13 Confidence Level: 4 AUTHORS: PMID:9514741 NOTES:kh 1/7/03 SAB m
fast: false
kinetic law: MODEL1310110063#
modifier: MODEL1310110063#
is version of: http://identifiers.org/ec-code/2.6.1.13
name: ornithine transaminase reversible (m)
is: SBO:0000176
reactant: MODEL1310110063#
is described by: ECO:0000269
reversible: true
product: MODEL1310110063#

metaM fadh2 m
is: HMDB01197
initial concentration: 1.0
is: CHEBI:58307
name: Flavin adenine dinucleotide reduced
boundary condition: false
is: SBO:0000247
initial amount: NaN
has only substance units: false
type: Species
is: C01352
constant: false
notes: FORMULA: C27H33N9O15P2 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00770 EHMN_ABBREVIATION: C01352

metaM fad m
is: HMDB01248
is: SBO:0000247
initial concentration: 1.0
is: CHEBI:16238
is: C00016
initial amount: NaN
constant: false
boundary condition: false
has only substance units: false
type: Species
notes: FORMULA: C27H31N9O15P2 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00026 EHMN_ABBREVIATION: C00016
name: Flavin adenine dinucleotide oxidized

metaM ps hs e
has only substance units: false
initial concentration: 1.0
is: SBO:0000247
name: phosphatidylserine
is: CHEBI:18303
type: Species
notes: FORMULA: C6H11NO6PFULLRCO2FULLR2CO2 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC02006
initial amount: NaN
boundary condition: false
constant: false

metaR SERCYSNaEx
modifier: MODEL1310110063#
name: L-serine/L-cysteine Na-dependent exchange (Ser-L in)
is: SBO:0000185
reversible: false
reactant: MODEL1310110063#
type: Reaction
kinetic law: MODEL1310110063#
is described by: ECO:0000269
product: MODEL1310110063#
notes: GENE_ASSOCIATION: (6509.1) or (6510.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14530974 NOTES:SAB see Kanai and Hediger 2004 (2003), PMID 14530974
fast: false

metaM thcrm hs g
name: trihexosyl ceramide
initial amount: NaN
constant: false
notes: FORMULA: C36H66NO17FULLRCO CHARGE: 0
initial concentration: 1.0
boundary condition: false
is: CHEBI:24636
type: Species
has only substance units: false
is: SBO:0000247

metaM fgam c
is: HMDB01308
type: Species
constant: false
notes: FORMULA: C8H13N2O9P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC01281 EHMN_ABBREVIATION: C04376
has only substance units: false
initial concentration: 1.0
is: SBO:0000247
boundary condition: false
initial amount: NaN
is: C04376
is: CHEBI:58426
name: N2-Formyl-N1-(5-phospho-D-ribosyl)glycinamide

metaR EX drib LPAREN e RPAREN
kinetic law: MODEL1310110063#
reactant: MODEL1310110063#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Deoxyribose exchange
type: Reaction

metaR r0083
fast: false
is described by: ECO:0000000
reversible: true
product: MODEL1310110063#
name: Oxalosuccinate:NADP+ oxidoreductase (decarboxylating) Citrate cycle (TCA cycle) EC:1.1.1.42
modifier: MODEL1310110063#
notes: GENE_ASSOCIATION: (AI971036.1) or (3417.1) or (3418.1) SUBSYSTEM: Unassigned EC Number: 1.1.1.42 Confidence Level: 0 AUTHORS: PMID:16489927,PMID:9866202 NOTES:
is version of: http://identifiers.org/ec-code/1.1.1.42
kinetic law: MODEL1310110063#
type: Reaction
reactant: MODEL1310110063#
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110063#_ae88018d_e4b1_4e16_863e_379ef14536da
is encoded by: hsa:4731
is: SBO:0000252
name: NDUFV3
initial amount: NaN
type: Species
constant: false
has only substance units: false
is: P56181
initial concentration: NaN
boundary condition: true

metaR GTMLTe
is described by: ECO:0000269
is: SBO:0000185
kinetic law: MODEL1310110063#
fast: false
name: g-glutamyltransferase (e)
notes: GENE_ASSOCIATION: (2679.1) or (2678.1) or (2678.3) or (2678.2) SUBSYSTEM: Glutathione metabolism EC Number: 2.3.2.2 Confidence Level: 4 AUTHORS: PMID:15469854 NOTES:NCD SAB e see Disussion section of PMID 15469854
reactant: MODEL1310110063#
modifier: MODEL1310110063#
is version of: http://identifiers.org/ec-code/2.3.2.2
product: MODEL1310110063#
type: Reaction
reversible: false

metaR FAOXC163GC142m
kinetic law: MODEL1310110063#
product: MODEL1310110063#
reactant: MODEL1310110063#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C16:3-->C14:2)gm
type: Reaction

metaR r0360
type: Reaction
fast: false
name: Glycolysis / Glyconeogenesis EC:2.7.1.1
reversible: false
product: MODEL1310110063#
reactant: MODEL1310110063#
is version of: http://identifiers.org/ec-code/6.2.1.16
is described by: ECO:0000000
modifier: MODEL1310110063#
is: SBO:0000176
notes: GENE_ASSOCIATION: (65985.1) or (R39999.1) SUBSYSTEM: Fructose and mannose metabolism EC Number: 2.7.1.1 Confidence Level: 0 AUTHORS: PMID:16906315,PMID:7061426,PMID:7150652,PMID:8717435 NOTES:
kinetic law: MODEL1310110063#

metaM mescon m
initial concentration: 1.0
is: CHEBI:36986
type: Species
is: SBO:0000247
initial amount: NaN
name: Mesaconate
notes: FORMULA: C5H4O4 CHARGE: -2 INCHI: InChI=1S/C5H6O4/c1-3(5(8)9)2-4(6)7/h2H,1H3,(H,6,7)(H,8,9)/p-2/b3-2+
boundary condition: false
constant: false
is: HMDB00749
has only substance units: false

metaR BILDGLCURt
notes: GENE_ASSOCIATION: (10599.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10358072,PMID:12507753,PMID:9334206 NOTES:NJ
kinetic law: MODEL1310110063#
is: SBO:0000185
reversible: true
product: MODEL1310110063#
type: Reaction
reactant: MODEL1310110063#
is described by: ECO:0000269
fast: false
modifier: MODEL1310110063#
name: bilirubin beta-diglucuronide transport via bicarbonate countertransport

metaR GLYC3Ptmc
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: added during gap filling. No evidence found for such a reaction. NOTES:added during gap filling. No evidence found for such a reaction.
name: glycerol-3-phopshate transport, cytoplasm
is described by: ECO:0000134
fast: false
reactant: MODEL1310110063#
kinetic law: MODEL1310110063#
reversible: true
is: SBO:0000185
type: Reaction
product: MODEL1310110063#

http://identifiers.org/biomodels.db/MODEL1310110063#_63c91207_68df_40c5_9396_f181478c2c66
constant: false
has only substance units: false
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:3423
is: SBO:0000252
type: Species
name: IDS
boundary condition: true
is: B4DGD7

metaR r0774
fast: false
modifier: MODEL1310110063#
reversible: true
name: Uroporphyrinogen I carboxy-lyase Porphyrin and chlorophyll metabolism EC:4.1.1.37
is version of: http://identifiers.org/ec-code/4.2.1.17
type: Reaction
is: SBO:0000176
notes: GENE_ASSOCIATION: (1962.1) or (3033.1) or (3030.1) or (3028.1) or (3295.1) SUBSYSTEM: Unassigned EC Number: 4.1.1.37 Confidence Level: 0 AUTHORS: PMID:17360334 NOTES:
is described by: ECO:0000000
reactant: MODEL1310110063#
is version of: http://identifiers.org/ec-code/1.1.1.35
product: MODEL1310110063#
kinetic law: MODEL1310110063#
is version of: http://identifiers.org/ec-code/4.2.1.107

metaR COAtr
name: COA transporter, endoplasmic reticulum
kinetic law: MODEL1310110063#
is: SBO:0000185
reactant: MODEL1310110063#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: NOTES:diffusion NJ
fast: false
product: MODEL1310110063#
reversible: true
is described by: ECO:0000000

metaM sgalside hs l
initial amount: NaN
is: SBO:0000247
notes: FORMULA: C24H45NO10SFULLRCO CHARGE: -1
type: Species
initial concentration: 1.0
constant: false
is: HMDB00904
has only substance units: false
boundary condition: false
name: sulfatide galactocerebroside
is: CHEBI:16349

metaM acrn x
name: O-acetylcarnitine
boundary condition: false
initial concentration: 1.0
notes: FORMULA: C9H17NO4 CHARGE: 0 INCHI: InChI=1S/C9H17NO4/c1-7(11)14-8(5-9(12)13)6-10(2,3)4/h8H,5-6H2,1-4H3/t8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00966 EHMN_ABBREVIATION: C02571
has only substance units: false
is: CHEBI:57589
initial amount: NaN
type: Species
is: HMDB00201
constant: false
is: SBO:0000247

metaR r0629
product: MODEL1310110063#
notes: GENE_ASSOCIATION: (AI926493.1) or (5167.1) or (5169.1) or (83594.1) SUBSYSTEM: Bile acid synthesis EC Number: 2.3.1.65 Confidence Level: 0 AUTHORS: PMID:10884298,PMID:12239217,PMID:12543708,PMID:15026425,PMID:3741411,PMID:6884990 NOTES:
reactant: MODEL1310110063#
is version of: http://identifiers.org/ec-code/3.1.4.1
reversible: true
kinetic law: MODEL1310110063#
is version of: http://identifiers.org/ec-code/3.6.1.22
modifier: MODEL1310110063#
is: SBO:0000176
name: Choloyl-CoA:glycine N-choloyltransferase Bile acid biosynthesis / Taurine and hypotaurine metabolism EC:2.3.1.65
is described by: ECO:0000000
type: Reaction
fast: false

metaM n2m2nm l
is: HMDB00573
notes: FORMULA: C58H97N5O41 CHARGE: 0
is: CHEBI:30825
has only substance units: false
is: SBO:0000247
initial amount: NaN
boundary condition: false
initial concentration: 1.0
type: Species
name: n2m2nmasn (w/o peptide linkage)
constant: false

metaR EX leugly LPAREN e RPAREN
kinetic law: MODEL1310110063#
reactant: MODEL1310110063#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for leucylglycine
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110063#_cfe045f5_9c02_4e40_a23b_9c37c735b3ef
initial concentration: NaN
is: P04843
constant: false
name: RPN1
has only substance units: false
type: Species
boundary condition: true
is: SBO:0000252
is encoded by: hsa:6184
initial amount: NaN

metaR r0086
is described by: ECO:0000000
reversible: false
fast: false
reactant: MODEL1310110063#
is version of: http://identifiers.org/ec-code/3.5.1.3
modifier: MODEL1310110063#
type: Reaction
name: 2-Oxoglutaramate amidohydrolase Glutamate metabolism EC:3.5.1.3
product: MODEL1310110063#
kinetic law: MODEL1310110063#
notes: GENE_ASSOCIATION: (56954.1) SUBSYSTEM: Urea cycle EC Number: 3.5.1.3 Confidence Level: 0 AUTHORS: PMID:3003502,PMID:319948,PMID:4436326,PMID:5114531,PMID:894284 NOTES:
is: SBO:0000176

metaM pcrn c
has only substance units: false
name: propionyl-carnitine
initial concentration: 1.0
initial amount: NaN
notes: FORMULA: C10H19NO4 CHARGE: 0 INCHI: InChI=1/C10H19NO4/c1-5-10(14)15-8(6-9(12)13)7-11(2,3)4/h8H,5-7H2,1-4H3
constant: false
is: SBO:0000247
boundary condition: false
type: Species
is: http://identifiers.org/pubchem.compound/107738
is: HMDB00824

http://identifiers.org/biomodels.db/MODEL1310110063#_b47cd906_3d83_4514_b2b1_fadb6b9ed696
type: Species
has only substance units: false
constant: false
boundary condition: true
name: NDUFS8
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:4728
is: SBO:0000252
is: O00217