metaR RE0926E
is: SBO:0000176
reversible: true
reactant: MODEL1310110061#
modifier: MODEL1310110061#
is version of: http://identifiers.org/ec-code/3.2.1.1
is described by: ECO:0000000
name: RE0926
type: Reaction
kinetic law: MODEL1310110061#
is version of: http://identifiers.org/ec-code/3.2.1.17
notes: GENE_ASSOCIATION: (276.1) or (277.1) or (278.1) or (279.1) or (276.1) or (277.1) or (278.1) or (279.1) or (280.1) or (84569.1) SUBSYSTEM: Starch and sucrose metabolism EC Number: 3.2.1.1 Confidence Level: 0 AUTHORS: PMID:385176,PMID:8528071,PMID:890964 NOTES:
product: MODEL1310110061#
fast: false

metaR EX Rtotal LPAREN e RPAREN
kinetic law: MODEL1310110061#
reactant: MODEL1310110061#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: R total exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110061#_783b21c1_a3ed_4bac_af13_295ac46246e1
is: Q9NX14
boundary condition: true
is encoded by: hsa:54539
constant: false
name: NDUFB11
initial amount: NaN
is: SBO:0000252
has only substance units: false
initial concentration: NaN
type: Species

metaR VALtec
name: L-valine transport via diffusion (extracellular to cytosol)
reactant: MODEL1310110061#
reversible: true
is described by: ECO:0000269
type: Reaction
product: MODEL1310110061#
fast: false
kinetic law: MODEL1310110061#
is: SBO:0000185
notes: GENE_ASSOCIATION: (8501.1) or (124935.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12930836,PMID:14624363,PMID:15659399 NOTES:SAB
modifier: MODEL1310110061#

metaR GLUDym
kinetic law: MODEL1310110061#
is described by: ECO:0000269
reversible: true
fast: false
name: glutamate dehydrogenase (NADP), mitochondrial
is: SBO:0000176
notes: GENE_ASSOCIATION: (2747.1) or (2746.1) SUBSYSTEM: Glutamate metabolism EC Number: 1.4.1.4 Confidence Level: 4 AUTHORS: PMID:12324473,PMID:3368458 NOTES:
type: Reaction
is version of: http://identifiers.org/ec-code/1.4.1.3
product: MODEL1310110061#
modifier: MODEL1310110061#
reactant: MODEL1310110061#

metaM Rtotal2 c
constant: false
initial amount: NaN
type: Species
is: HMDB00095
notes: FORMULA: CO2FULLR2 CHARGE: -1
has only substance units: false
name: R total 2 position
is: SBO:0000247
boundary condition: false
initial concentration: 1.0
is: CHEBI:60377
is: C00055

metaM dece3coa m
type: Species
has only substance units: false
name: 3-decenoylcoa
is: http://identifiers.org/pubchem.compound/16019966
initial amount: NaN
is: SBO:0000247
constant: false
initial concentration: 1.0
notes: FORMULA: C31H48N7O17P3S CHARGE: -4
boundary condition: false

metaR LTD4DP
is described by: ECO:0000000
reversible: true
kinetic law: MODEL1310110061#
notes: GENE_ASSOCIATION: SUBSYSTEM: Eicosanoid metabolism EC Number: 2.3.2.2 Confidence Level: 4 AUTHORS: PMID:11160764,PMID:3001504 NOTES:Converts leukotriene D4 (LTD4) to leukotriene E4 (LTE4). unknown compartmentalization, cytosolic by default NJ
product: MODEL1310110061#
type: Reaction
reactant: MODEL1310110061#
name: Leukotriene D4 dipeptidase
is: SBO:0000176
fast: false

metaM cmp e
is: CHEBI:60377
notes: FORMULA: C9H12N3O8P CHARGE: -2 INCHI: InChI=1S/C9H14N3O8P/c10-5-1-2-12(9(15)11-5)8-7(14)6(13)4(20-8)3-19-21(16,17)18/h1-2,4,6-8,13-14H,3H2,(H2,10,11,15)(H2,16,17,18)/p-2/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00060 EHMN_ABBREVIATION: C00055
has only substance units: false
type: Species
is: HMDB00095
is: SBO:0000247
name: CMP(2-)
initial concentration: 1.0
constant: false
initial amount: NaN
boundary condition: false

metaM co2 e
is: HMDB01967
notes: FORMULA: CO2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00021 EHMN_ABBREVIATION: C00011
has only substance units: false
type: Species
is: SBO:0000247
initial concentration: 1.0
is: C00011
constant: false
is: CHEBI:16526
initial amount: NaN
boundary condition: false
name: CO2

metaM ps hs e
initial concentration: 1.0
boundary condition: false
notes: FORMULA: C6H11NO6PFULLRCO2FULLR2CO2 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC02006
is: CHEBI:18303
type: Species
has only substance units: false
constant: false
initial amount: NaN
name: phosphatidylserine
is: SBO:0000247

metaR r0360
type: Reaction
reversible: false
fast: false
is described by: ECO:0000000
reactant: MODEL1310110061#
notes: GENE_ASSOCIATION: (65985.1) or (R39999.1) SUBSYSTEM: Fructose and mannose metabolism EC Number: 2.7.1.1 Confidence Level: 0 AUTHORS: PMID:16906315,PMID:7061426,PMID:7150652,PMID:8717435 NOTES:
is version of: http://identifiers.org/ec-code/6.2.1.16
name: Glycolysis / Glyconeogenesis EC:2.7.1.1
is: SBO:0000176
kinetic law: MODEL1310110061#
modifier: MODEL1310110061#
product: MODEL1310110061#

metaR EX galside hs LPAREN e RPAREN
kinetic law: MODEL1310110061#
reactant: MODEL1310110061#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: D-galactosyl-N-acylsphingosine exchange
type: Reaction

metaR NDPK7m
is version of: http://identifiers.org/ec-code/2.7.4.6
is: SBO:0000176
notes: GENE_ASSOCIATION: (4833.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.6 Confidence Level: 2 AUTHORS: PMID:9099850 NOTES:Many nucleoside diphosphates (eight described) can act as acceptors. While many ribo- and deoxyribonucleoside triphosphates can act as donors, only ATP is chosen as a donor to minimize the number of total reactions.
type: Reaction
is described by: ECO:0000254
fast: false
reactant: MODEL1310110061#
product: MODEL1310110061#
reversible: true
kinetic law: MODEL1310110061#
name: nucleoside-diphosphate kinase (ATP:dCDP), mitochondrial
modifier: MODEL1310110061#

metaR PROD2m
reactant: MODEL1310110061#
fast: false
is described by: ECO:0000254
name: Proline dehydrogenase (m)
is version of: http://identifiers.org/ec-code/1.5.99.8
type: Reaction
notes: GENE_ASSOCIATION: (5625.1) SUBSYSTEM: Arginine and Proline Metabolism EC Number: 1.5.99.8 Confidence Level: 2 AUTHORS: PMID:10192398 NOTES:JLR SAB m
is: SBO:0000176
reversible: false
kinetic law: MODEL1310110061#
product: MODEL1310110061#
modifier: MODEL1310110061#

metaM 5dpmev c
initial concentration: 1.0
constant: false
initial amount: NaN
type: Species
name: (R)-5-Diphosphomevalonate
is: HMDB01090
has only substance units: false
boundary condition: false
is: SBO:0000247
notes: FORMULA: C6H10O10P2 CHARGE: -4 INCHI: InChI=1S/C6H14O10P2/c1-6(9,4-5(7)8)2-3-15-18(13,14)16-17(10,11)12/h9H,2-4H2,1H3,(H,7,8)(H,13,14)(H2,10,11,12)/t6-/m1/s1

http://identifiers.org/biomodels.db/MODEL1310110061#_c334847c_a083_4d36_8f67_15e8f69756ff
is: O95477
initial amount: NaN
name: ABCA1
boundary condition: true
initial concentration: NaN
has only substance units: false
is: SBO:0000252
constant: false
type: Species
is encoded by: hsa:19

metaM dcsptn1coa m
notes: FORMULA: C43H64N7O17P3S CHARGE: -4 INCHI: InChI=1/C43H68N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-34(52)71-27-26-45-33(51)24-25-46-41(55)38(54)43(2,3)29-64-70(61,62)67-69(59,60)63-28-32-37(66-68(56,57)58)36(53)42(65-32)50-31-49-35-39(44)47-30-48-40(35)50/h8-9,11-12,14-15,17-18,20-21,30-32,36-38,42,53-54H,4-7,10,13,16,19,22-29H2,1-3H3,(H,45,51)(H,46,55)(H,59,60)(H,61,62)(H2,44,47,48)(H2,56,57,58)/b9-8-,12-11-,15-14-,18-17-,21-20-/t32-,36-,37?,38+,42-/m1/s1
type: Species
is: C16173
has only substance units: false
constant: false
initial concentration: 1.0
name: docosa-4,7,10,13,16-pentaenoyl coenzyme A
initial amount: NaN
is: http://identifiers.org/pubchem.compound/47205483
is: HMDB06513
is: SBO:0000247
boundary condition: false

metaR APOC LYS BTNP
fast: false
type: Reaction
kinetic law: MODEL1310110061#
is described by: ECO:0000000
reactant: MODEL1310110061#
is: SBO:0000176
reversible: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Biotin metabolism EC Number: Confidence Level: 2 AUTHORS: NOTES:
name: proteolysis of apoC-Lys-btn
product: MODEL1310110061#

metaM crmp hs c
initial concentration: 1.0
notes: FORMULA: C18H35NO5PFULLRCO CHARGE: -2 EHMN_ABBREVIATION: C02960
constant: false
is: CHEBI:57674
is: SBO:0000247
name: ceramide 1-phosphate(2-)
type: Species
initial amount: NaN
has only substance units: false
boundary condition: false

metaR r2344
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
reversible: true
fast: false
is: SBO:0000185
reactant: MODEL1310110061#
is described by: ECO:0000000
type: Reaction
product: MODEL1310110061#
kinetic law: MODEL1310110061#
name: Organic anion transporter 5 Utilized transport

metaR r2139
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.14
fast: false
product: MODEL1310110061#
modifier: MODEL1310110061#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
is described by: ECO:0000000
reversible: true
is: SBO:0000185
kinetic law: MODEL1310110061#
reactant: MODEL1310110061#
type: Reaction

metaR r0013
product: MODEL1310110061#
notes: GENE_ASSOCIATION: (3073.1) or (3074.1) SUBSYSTEM: Aminosugar metabolism EC Number: 3.2.1.52 Confidence Level: 0 AUTHORS: PMID:10481922,PMID:2423070,PMID:6219664,PMID:758959 NOTES:
modifier: MODEL1310110061#
is: SBO:0000176
fast: false
reversible: false
type: Reaction
name: beta-N-acetylhexosaminidase Aminosugars metabolism EC:3.2.1.52
kinetic law: MODEL1310110061#
is version of: http://identifiers.org/ec-code/3.2.1.52
reactant: MODEL1310110061#
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110061#_4129a96f_3288_4a75_b591_4c73dd2dd119
has only substance units: false
is: SBO:0000252
is: Q12908
boundary condition: true
name: SLC10A2
initial amount: NaN
is encoded by: hsa:6555
constant: false
type: Species
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110061#_dc8b9fa8_2187_41d7_a5ff_70da2f31be83
boundary condition: true
is: SBO:0000252
name: GGCT
is encoded by: hsa:79017
initial concentration: NaN
constant: false
is: B8ZZR8
has only substance units: false
type: Species
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110061#_dcc19667_8b1a_4050_a0b6_63d3887863a6
boundary condition: true
has only substance units: false
initial concentration: NaN
initial amount: NaN
is: P15104
is: SBO:0000252
constant: false
name: GLUL
is encoded by: hsa:2752
type: Species

metaM acetone c
initial concentration: 1.0
is: CHEBI:15347
notes: FORMULA: C3H6O CHARGE: 0 INCHI: InChI=1S/C3H6O/c1-3(2)4/h1-2H3 HEPATONET_1.0_ABBREVIATION: HC00193 EHMN_ABBREVIATION: C00207
has only substance units: false
initial amount: NaN
constant: false
name: acetone
is: HMDB01659
type: Species
boundary condition: false
is: SBO:0000247

metaR RE3005M
modifier: MODEL1310110061#
is described by: ECO:0000000
type: Reaction
product: MODEL1310110061#
is version of: http://identifiers.org/ec-code/4.2.1.107
notes: GENE_ASSOCIATION: (3295.1) or (1962.1) or (3033.1) or (3028.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.1.1.35 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:7775433 NOTES:
name: RE3005
fast: false
kinetic law: MODEL1310110061#
reactant: MODEL1310110061#
reversible: true
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.1.1.35

metaM retinal cis 9 c
type: Species
is: HMDB01358
is: CHEBI:17898
notes: FORMULA: C20H28O CHARGE: 0 INCHI: InChI=1S/C20H28O/c1-16(8-6-9-17(2)13-15-21)11-12-19-18(3)10-7-14-20(19,4)5/h6,8-9,11-13,15H,7,10,14H2,1-5H3/b9-6+,12-11+,16-8+,17-13+ EHMN_ABBREVIATION: CE5575
boundary condition: false
initial amount: NaN
constant: false
name: all-trans-retinal
has only substance units: false
is: SBO:0000247
initial concentration: 1.0

metaR PRPNCOAHYDm
modifier: MODEL1310110061#
reversible: false
is: SBO:0000176
fast: false
product: MODEL1310110061#
is version of: http://identifiers.org/ec-code/2.3.1.16
reactant: MODEL1310110061#
is version of: http://identifiers.org/ec-code/4.2.1.18
is described by: ECO:0000134
is version of: http://identifiers.org/ec-code/4.2.1.17
notes: GENE_ASSOCIATION: (1892.1) or (3030.1) and (3032.1) or (549.1) SUBSYSTEM: beta-Alanine metabolism EC Number: 4.2.1.17 Confidence Level: 1 AUTHORS: PMID:8824301 NOTES:SAB made up name because name in KEGG seemed wrong. in vitro assay
kinetic law: MODEL1310110061#
name: Propenoyl-CoA hydrolase (m)
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110061#_41ec35e9_ab96_4c74_91d7_6c80c94f2368
constant: false
is: SBO:0000297
boundary condition: true
initial amount: NaN
has part: B4E3E9
type: Species
has only substance units: false
initial concentration: NaN
name: DLD:DLST:OGDH:PDHX
is encoded by: hsa:4967

metaM ficytC m
has only substance units: false
initial concentration: 1.0
is: CHEBI:15991
initial amount: NaN
notes: FORMULA: C42H54FeN8O6S2 CHARGE: 3 HEPATONET_1.0_ABBREVIATION: HC00123
name: Ferricytochrome c
constant: false
boundary condition: false
is: SBO:0000247
type: Species

metaR EX pi LPAREN e RPAREN
kinetic law: MODEL1310110061#
reactant: MODEL1310110061#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Phosphate exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110061#_d976fd0c_2b94_455b_ad24_afa98bb8a808
constant: false
has only substance units: false
is: Q99798
initial amount: NaN
type: Species
initial concentration: NaN
is encoded by: hsa:50
name: ACO2
boundary condition: true
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110061#_4d1a4755_aaff_4332_bcc1_2767f893b5dc
is encoded by: hsa:8801
has only substance units: false
type: Species
has part: Q96I99
has part: P53597
boundary condition: true
initial concentration: NaN
is: SBO:0000297
initial amount: NaN
name: SUCLG2:SUCLG1
constant: false
is encoded by: hsa:8802

metaR UREAt5
name: urea, water cotransport
is: SBO:0000185
type: Reaction
fast: false
reversible: true
kinetic law: MODEL1310110061#
reactant: MODEL1310110061#
modifier: MODEL1310110061#
notes: GENE_ASSOCIATION: (6523.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:11024018,PMID:11034615,PMID:12748858,PMID:2490366,PMID:8063771 NOTES:NCD
is described by: ECO:0000269
product: MODEL1310110061#

metaM HC01842 c
name: Phosphodimethylethanolamine
is: SBO:0000247
has only substance units: false
boundary condition: false
constant: false
initial amount: NaN
is: CHEBI:31997
type: Species
initial concentration: 1.0
notes: FORMULA: C4H10NO4P CHARGE: -2 INCHI: InChI=1S/C4H12NO4P/c1-5(2)3-4-9-10(6,7)8/h3-4H2,1-2H3,(H2,6,7,8)

http://identifiers.org/biomodels.db/MODEL1310110061#_fef290f6_ee23_411f_8dba_51fa4e0acb50
boundary condition: true
name: PLA2G1B
initial concentration: NaN
is: P04054
has only substance units: false
constant: false
type: Species
is encoded by: hsa:5319
is: SBO:0000252
initial amount: NaN

metaR ASNTHRNaEx
is described by: ECO:0000269
modifier: MODEL1310110061#
kinetic law: MODEL1310110061#
fast: false
name: L-threonine/L-asparagine Na-dependent exchange (Asn-L in)
product: MODEL1310110061#
reversible: false
is: SBO:0000185
reactant: MODEL1310110061#
type: Reaction
notes: GENE_ASSOCIATION: (6510.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14530974 NOTES:SAB see Kanai and Hediger 2004 (2003), PMID 14530974

http://identifiers.org/biomodels.db/MODEL1310110061#_d78d908b_c23b_4e70_9f05_83d67c8892e9
boundary condition: true
initial amount: NaN
is encoded by: hsa:4720
name: NDUFS2
is: SBO:0000252
type: Species
has only substance units: false
is: B7Z792
constant: false
initial concentration: NaN

metaR HSD3A1r
reactant: MODEL1310110061#
modifier: MODEL1310110061#
is version of: http://identifiers.org/ec-code/1.1.1.225
reversible: true
fast: false
is: SBO:0000176
product: MODEL1310110061#
type: Reaction
notes: GENE_ASSOCIATION: (1109.1) SUBSYSTEM: Steroid metabolism EC Number: 1.1.1.225 Confidence Level: 4 AUTHORS: PMID:14643063,PMID:7650035 NOTES:Microsomal rxn see PMID: 14643063 substrate specificity still not clear (nad vs nadp) NJ
is described by: ECO:0000269
name: 3 alpha-hydroxysteroid dehydrogenase (type 3)
kinetic law: MODEL1310110061#

metaM sbt D c
type: Species
initial amount: NaN
boundary condition: false
notes: FORMULA: C6H14O6 CHARGE: 0 INCHI: InChI=1S/C6H14O6/c7-1-3(9)5(11)6(12)4(10)2-8/h3-12H,1-2H2/t3-,4+,5-,6-/m1/s1
has only substance units: false
name: D-glucitol
is: HMDB00247
initial concentration: 1.0
is: SBO:0000247
is: CHEBI:17924
constant: false

metaR LEUtec
reversible: true
type: Reaction
notes: GENE_ASSOCIATION: (8501.1) or (124935.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12930836,PMID:14624363,PMID:15659399 NOTES:SAB
kinetic law: MODEL1310110061#
is described by: ECO:0000269
modifier: MODEL1310110061#
name: L-leucine transport via diffusion (extracellular to cytosol)
fast: false
reactant: MODEL1310110061#
is: SBO:0000185
product: MODEL1310110061#

http://identifiers.org/biomodels.db/MODEL1310110061#_a3324db9_812a_484c_97af_dc4fa56b9da7
type: Species
is: SBO:0000252
is: P14618
constant: false
is encoded by: hsa:5315
name: PKM2
initial concentration: NaN
initial amount: NaN
boundary condition: true
has only substance units: false

metaR r0139
is version of: http://identifiers.org/ec-code/2.3.2.2
name: CDP diphosphohydrolase Pyrimidine metabolism EC:3.6.1.5
modifier: MODEL1310110061#
is: SBO:0000176
reversible: true
type: Reaction
notes: GENE_ASSOCIATION: (AI222095.1) or (AI697028.1) or (D87002.1) or (2678.1) or (728441.1) or (2687.1) or (2686.1) or (728226.1) or (NM_013421.1) SUBSYSTEM: Pyrimidine catabolism EC Number: 3.6.1.5 Confidence Level: 0 AUTHORS: PMID:15652174,PMID:16752921,PMID:17095758 NOTES:
reactant: MODEL1310110061#
product: MODEL1310110061#
is described by: ECO:0000000
fast: false
kinetic law: MODEL1310110061#

http://identifiers.org/biomodels.db/MODEL1310110061#_addbc719_c845_4107_aa17_79021b508cf8
initial concentration: NaN
is: SBO:0000252
boundary condition: true
is: P28329
initial amount: NaN
is encoded by: hsa:1103
has only substance units: false
name: CHAT
constant: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110061#_d6f10b88_3f96_4da9_a0bc_fb489bb4db30
is: Q7LG56
boundary condition: true
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:50484
constant: false
initial amount: NaN
has only substance units: false
type: Species
name: RRM2B

metaR UMPK
type: Reaction
fast: false
reactant: MODEL1310110061#
is: SBO:0000176
name: UMP kinase
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: NOTES:
reversible: true
product: MODEL1310110061#
is version of: http://identifiers.org/ec-code/2.7.4.14
modifier: MODEL1310110061#
is described by: ECO:0000269
kinetic law: MODEL1310110061#

http://identifiers.org/biomodels.db/MODEL1310110061#_8bb25366_da0a_44c4_8b27_c0a840fbef05
name: GALNT6
constant: false
boundary condition: true
is encoded by: hsa:11226
initial concentration: NaN
is: SBO:0000252
initial amount: NaN
has only substance units: false
is: Q8NCL4
type: Species

metaR r0774
name: Uroporphyrinogen I carboxy-lyase Porphyrin and chlorophyll metabolism EC:4.1.1.37
type: Reaction
product: MODEL1310110061#
notes: GENE_ASSOCIATION: (1962.1) or (3033.1) or (3030.1) or (3028.1) or (3295.1) SUBSYSTEM: Unassigned EC Number: 4.1.1.37 Confidence Level: 0 AUTHORS: PMID:17360334 NOTES:
is version of: http://identifiers.org/ec-code/4.2.1.17
reversible: true
fast: false
is version of: http://identifiers.org/ec-code/4.2.1.107
modifier: MODEL1310110061#
is described by: ECO:0000000
reactant: MODEL1310110061#
kinetic law: MODEL1310110061#
is version of: http://identifiers.org/ec-code/1.1.1.35
is: SBO:0000176

metaM dudp m
boundary condition: false
is: CHEBI:60471
constant: false
is: HMDB01000
has only substance units: false
is: SBO:0000247
initial concentration: 1.0
initial amount: NaN
type: Species
notes: FORMULA: C9H11N2O11P2 CHARGE: -3 INCHI: InChI=1S/C9H14N2O11P2/c12-5-3-8(11-2-1-7(13)10-9(11)14)21-6(5)4-20-24(18,19)22-23(15,16)17/h1-2,5-6,8,12H,3-4H2,(H,18,19)(H,10,13,14)(H2,15,16,17)/p-3/t5-,6+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00768 EHMN_ABBREVIATION: C01346
name: dUDP(3-)

http://identifiers.org/biomodels.db/MODEL1310110061#_a6698f26_92dd_4667_a5bc_64b82e0e5e29
is encoded by: hsa:2523
type: Species
is: SBO:0000252
constant: false
boundary condition: true
name: FUT1
initial amount: NaN
is: Q6IZA2
has only substance units: false
initial concentration: NaN

metaM but c
notes: FORMULA: C4H7O2 CHARGE: -1 INCHI: InChI=1S/C4H8O2/c1-2-3-4(5)6/h2-3H2,1H3,(H,5,6)/p-1 HEPATONET_1.0_ABBREVIATION: HC00223 EHMN_ABBREVIATION: C00246
name: butyrate
initial concentration: 1.0
is: HMDB00039
has only substance units: false
is: CHEBI:17968
type: Species
is: SBO:0000247
boundary condition: false
constant: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110061#_ae2dc3b6_f2e9_4a25_bdca_10fc1f9b6b56
name: HK1
is: P78542
has only substance units: false
is: SBO:0000252
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:3098
constant: false
boundary condition: true
type: Species

http://identifiers.org/biomodels.db/MODEL1310110061#_8eb394e0_33e1_44ee_9620_b552ce3fbf89
type: Species
name: _AL048840_1_c
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:AL048840
constant: false
has only substance units: false
boundary condition: true
initial amount: NaN

metaR r0842
reversible: true
is: SBO:0000185
is version of: http://identifiers.org/ec-code/1.3.1.72
modifier: MODEL1310110061#
fast: false
is described by: ECO:0000000
product: MODEL1310110061#
type: Reaction
kinetic law: MODEL1310110061#
name: Postulated transport reaction
notes: GENE_ASSOCIATION: (1718.1) SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:7050120 NOTES:
reactant: MODEL1310110061#

metaM cmp c
initial amount: NaN
is: CHEBI:60377
type: Species
name: CMP
is: HMDB00095
initial concentration: 1.0
is: C00055
is: SBO:0000247
boundary condition: false
notes: FORMULA: C9H12N3O8P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00060 EHMN_ABBREVIATION: C00055
constant: false
has only substance units: false

metaM co2 c
initial amount: NaN
is: HMDB01967
type: Species
is: CHEBI:3313
initial concentration: 1.0
is: SBO:0000247
name: CO2
is: C00011
boundary condition: false
constant: false
notes: FORMULA: CO2 CHARGE: 0
has only substance units: false

metaM HC02213 e
notes: FORMULA: C20H29O5 CHARGE: -1 INCHI: InChI=1S/C20H30O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h3-4,6-7,12-13,15-17,19,21,23H,2,5,8-11,14H2,1H3,(H,24,25)/b6-3-,7-4-,13-12+/t15-,16+,17+,19+/m0/s1 EHMN_ABBREVIATION: C06439
name: prostaglandin-e3
initial concentration: 1.0
is: SBO:0000247
is: CHEBI:28031
has only substance units: false
boundary condition: false
initial amount: NaN
constant: false
type: Species

metaM crmp hs e
type: Species
initial concentration: 1.0
name: ceramide 1-phosphate(2-)
constant: false
initial amount: NaN
has only substance units: false
boundary condition: false
notes: FORMULA: C18H35NO5PFULLRCO CHARGE: -2 EHMN_ABBREVIATION: C02960
is: SBO:0000247
is: CHEBI:57674

http://identifiers.org/biomodels.db/MODEL1310110061#_599f6285_bc58_4d53_bf9b_4e0b19172e74
is encoded by: hsa:R06874
initial amount: NaN
name: _R06874_1_r
constant: false
boundary condition: true
has only substance units: false
type: Species
is: SBO:0000252
initial concentration: NaN

metaR EX malcoa LPAREN e RPAREN
kinetic law: MODEL1310110061#
reactant: MODEL1310110061#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: malonyl-CoA(4-) exchange
type: Reaction

metaR 4HPRO LTte
name: Transport of trans-4-hydroxy-L-proline
reactant: MODEL1310110061#
type: Reaction
reversible: true
product: MODEL1310110061#
is described by: ECO:0000134
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
fast: false
is: SBO:0000185
kinetic law: MODEL1310110061#

metaR r1723
reactant: MODEL1310110061#
is described by: ECO:0000000
is: SBO:0000185
reversible: false
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
name: Y+LAT2 Utilized transport
product: MODEL1310110061#
fast: false
kinetic law: MODEL1310110061#
modifier: MODEL1310110061#
type: Reaction

metaR r2137
fast: false
modifier: MODEL1310110061#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12811560 NOTES:
reversible: true
is described by: ECO:0000000
kinetic law: MODEL1310110061#
is: SBO:0000185
name: Major Facilitator(MFS) TCDB:2.A.1.14.6
reactant: MODEL1310110061#
type: Reaction
product: MODEL1310110061#

metaR r2342
reversible: true
fast: false
reactant: MODEL1310110061#
is: SBO:0000185
product: MODEL1310110061#
is described by: ECO:0000000
type: Reaction
kinetic law: MODEL1310110061#
name: Organic anion transporter 5 Utilized transport
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110061#_951c157f_3697_4117_8287_edca6e864eff
is: SBO:0000252
initial amount: NaN
type: Species
constant: false
name: STS
has only substance units: false
is encoded by: hsa:412
initial concentration: NaN
is: P08842
boundary condition: true

metaR FAOXC185m
kinetic law: MODEL1310110061#
product: MODEL1310110061#
reactant: MODEL1310110061#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: isomerization(C18:5)m
type: Reaction

metaR DNDPt26m
kinetic law: MODEL1310110061#
name: dCDP transport via dUDP antiport
is described by: ECO:0000269
fast: false
reactant: MODEL1310110061#
notes: GENE_ASSOCIATION: (60386.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:11226231 NOTES:IT
product: MODEL1310110061#
reversible: false
is: SBO:0000185
modifier: MODEL1310110061#
type: Reaction

metaM acetone e
is: CHEBI:15347
constant: false
initial concentration: 1.0
notes: FORMULA: C3H6O CHARGE: 0 INCHI: InChI=1S/C3H6O/c1-3(2)4/h1-2H3 HEPATONET_1.0_ABBREVIATION: HC00193 EHMN_ABBREVIATION: C00207
has only substance units: false
is: HMDB01659
name: acetone
type: Species
is: SBO:0000247
boundary condition: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110061#_f3c6168d_c471_4fe7_a30a_370e69d03644
type: Species
constant: false
is: SBO:0000252
initial concentration: NaN
initial amount: NaN
boundary condition: true
name: _LOC727762_1_m
has only substance units: false
is encoded by: hsa:LOC727762

metaR GLUDxm
reactant: MODEL1310110061#
notes: GENE_ASSOCIATION: (2747.1) or (2746.1) SUBSYSTEM: Glutamate metabolism EC Number: 1.4.1.3 Confidence Level: 4 AUTHORS: PMID:12324473,PMID:3368458 NOTES:
reversible: true
kinetic law: MODEL1310110061#
product: MODEL1310110061#
name: glutamate dehydrogenase (NAD) (mitochondrial)
modifier: MODEL1310110061#
is: SBO:0000176
type: Reaction
fast: false
is version of: http://identifiers.org/ec-code/1.4.1.3
is described by: ECO:0000269

metaM lthstrl r
is: SBO:0000247
has only substance units: false
initial concentration: 1.0
initial amount: NaN
type: Species
name: 5alpha-cholest-7-en-3beta-ol
boundary condition: false
is: CHEBI:17168
notes: FORMULA: C27H46O CHARGE: 0 INCHI: InChI=1S/C27H46O/c1-18(2)7-6-8-19(3)23-11-12-24-22-10-9-20-17-21(28)13-15-26(20,4)25(22)14-16-27(23,24)5/h10,18-21,23-25,28H,6-9,11-17H2,1-5H3/t19-,20+,21+,23-,24+,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00706 EHMN_ABBREVIATION: C01189
is: HMDB01170
constant: false

http://identifiers.org/biomodels.db/MODEL1310110061#_656a45af_f5ac_406c_a953_97fad4f75e94
is encoded by: hsa:7358
boundary condition: true
initial amount: NaN
initial concentration: NaN
is: SBO:0000252
constant: false
has only substance units: false
name: UGDH
type: Species
is: O60701

metaR EX ala L LPAREN e RPAREN
kinetic law: MODEL1310110061#
reactant: MODEL1310110061#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for L-alanine
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110061#_6e1e9a8b_2d8b_499e_bccb_9ef89ccf06cc
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:4726
type: Species
constant: false
initial amount: NaN
is: Q6IBC4
has only substance units: false
boundary condition: true
name: NDUFS6

http://identifiers.org/biomodels.db/MODEL1310110061#_1e394a1b_eed7_4909_be47_a6654c09846e
has only substance units: false
is encoded by: hsa:8170
initial concentration: NaN
is: Q15849
boundary condition: true
type: Species
initial amount: NaN
is: SBO:0000252
name: SLC14A2
constant: false

http://identifiers.org/biomodels.db/MODEL1310110061#_24c3f60c_aef3_4ea7_ac06_339a8b96c8ad
is: Q9UNU6
constant: false
name: CYP8B1
has only substance units: false
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:1582
boundary condition: true
is: SBO:0000252
type: Species

metaM 2dp6mobq me m
notes: FORMULA: C58H88O3 CHARGE: 0 INCHI: InChI=1S/C58H88O3/c1-44(2)23-14-24-45(3)25-15-26-46(4)27-16-28-47(5)29-17-30-48(6)31-18-32-49(7)33-19-34-50(8)35-20-36-51(9)37-21-38-52(10)39-22-40-53(11)41-42-55-54(12)56(59)43-57(61-13)58(55)60/h23,25,27,29,31,33,35,37,39,41,43H,14-22,24,26,28,30,32,34,36,38,40,42H2,1-13H3/b45-25+,46-27+,47-29+,48-31+,49-33+,50-35+,51-37+,52-39+,53-41+
name: 2-decaprenyl-6-methoxy-3-methyl-1,4-benzoquinone
constant: false
initial amount: NaN
initial concentration: 1.0
has only substance units: false
is: CHEBI:50772
type: Species
boundary condition: false
is: SBO:0000247

metaR r1722
name: Y+LAT2 Utilized transport
product: MODEL1310110061#
kinetic law: MODEL1310110061#
is: SBO:0000185
type: Reaction
reversible: false
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reactant: MODEL1310110061#
fast: false
modifier: MODEL1310110061#
is described by: ECO:0000000

metaR r2343
is: SBO:0000185
kinetic law: MODEL1310110061#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
reversible: true
reactant: MODEL1310110061#
is described by: ECO:0000000
type: Reaction
name: Organic anion transporter 5 Utilized transport
product: MODEL1310110061#
fast: false

http://identifiers.org/biomodels.db/MODEL1310110061#_0cea5696_d423_4922_8b91_58e2487b2cce
initial amount: NaN
has only substance units: false
name: LEFTY1
is: SBO:0000252
is: O75610
is encoded by: hsa:10637
boundary condition: true
initial concentration: NaN
constant: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110061#_9aab23d3_51cf_4a0c_bd03_4b8c31a0c02d
is encoded by: hsa:250
name: ALPP
boundary condition: true
is: P05187
type: Species
has only substance units: false
initial amount: NaN
is: SBO:0000252
constant: false
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110061#_1c11aca2_2661_45cc_a1fa_ae5ef76dc733
has only substance units: false
boundary condition: true
is encoded by: hsa:3030
initial concentration: NaN
initial amount: NaN
name: HADHA
is: E9KL44
constant: false
is: SBO:0000252
type: Species

http://identifiers.org/biomodels.db/MODEL1310110061#_c8c92599_a58a_40c1_aea2_2e900faed775
is: SBO:0000252
has only substance units: false
constant: false
name: INPP1
is encoded by: hsa:3628
initial concentration: NaN
is: P49441
boundary condition: true
type: Species
initial amount: NaN

metaM cholcoar x
constant: false
type: Species
is: CHEBI:58677
notes: FORMULA: C48H76N7O20P3S CHARGE: -4 INCHI: InChI=1S/C48H80N7O20P3S/c1-25(29-10-11-30-36-31(20-34(58)48(29,30)6)47(5)14-12-28(56)18-27(47)19-32(36)57)8-7-9-26(2)45(63)79-17-16-50-35(59)13-15-51-43(62)40(61)46(3,4)22-72-78(69,70)75-77(67,68)71-21-33-39(74-76(64,65)66)38(60)44(73-33)55-24-54-37-41(49)52-23-53-42(37)55/h23-34,36,38-40,44,56-58,60-61H,7-22H2,1-6H3,(H,50,59)(H,51,62)(H,67,68)(H,69,70)(H2,49,52,53)(H2,64,65,66)/p-4/t25-,26-,27+,28-,29-,30+,31+,32-,33-,34+,36+,38-,39-,40+,44-,47+,48-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01348 EHMN_ABBREVIATION: C04760
name: (25R)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-oyl-CoA(4-)
has only substance units: false
initial amount: NaN
is: HMDB02178
initial concentration: 1.0
is: SBO:0000247
boundary condition: false

metaR FADH2tru
product: MODEL1310110061#
is described by: ECO:0000000
reversible: false
reactant: MODEL1310110061#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: NOTES:diffusion - but unidirectional uptake into ER (to avoid loops w/ NAD/NADP) NJ
kinetic law: MODEL1310110061#
fast: false
is: SBO:0000185
type: Reaction
name: FADH2 transporter, endoplasmic reticulum

metaR FACOAL1822
notes: GENE_ASSOCIATION: (2180.1) SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 4 AUTHORS: PMID:15292367 NOTES:NJ
type: Reaction
is: SBO:0000176
kinetic law: MODEL1310110061#
is version of: http://identifiers.org/ec-code/6.2.1.3
is described by: ECO:0000269
reversible: true
product: MODEL1310110061#
fast: false
name: fatty-acid--CoA ligase
reactant: MODEL1310110061#
modifier: MODEL1310110061#

metaM but e
is: HMDB00039
name: butyrate
notes: FORMULA: C4H7O2 CHARGE: -1 INCHI: InChI=1S/C4H8O2/c1-2-3-4(5)6/h2-3H2,1H3,(H,5,6)/p-1 HEPATONET_1.0_ABBREVIATION: HC00223 EHMN_ABBREVIATION: C00246
is: CHEBI:17968
type: Species
constant: false
initial amount: NaN
initial concentration: 1.0
is: SBO:0000247
has only substance units: false
boundary condition: false

metaR OCDCEAtr
type: Reaction
name: fatty acid transport via diffusion
reversible: true
is: SBO:0000185
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11788354,PMID:12864740 NOTES:NJ
product: MODEL1310110061#
reactant: MODEL1310110061#
is described by: ECO:0000000
kinetic law: MODEL1310110061#

metaM HC02023 r
is: CHEBI:46898
initial concentration: 1.0
initial amount: NaN
name: Cholesterol-ester-ol
has only substance units: false
constant: false
boundary condition: false
notes: FORMULA: C45H78O2 CHARGE: 0 INCHI: InChI=1S/C45H78O2/c1-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-25-43(46)47-38-30-32-44(5)37(34-38)26-27-39-41-29-28-40(36(4)24-22-23-35(2)3)45(41,6)33-31-42(39)44/h14-15,26,35-36,38-42H,7-13,16-25,27-34H2,1-6H3/b15-14-/t36-,38+,39+,40-,41+,42+,44+,45-/m1/s1
type: Species
is: SBO:0000247

metaM adrncoa c
constant: false
has only substance units: false
is: C16170
type: Species
is: http://identifiers.org/pubchem.compound/47205480
name: adrenyl coenzyme A
notes: FORMULA: C43H66N7O17P3S CHARGE: -4 INCHI: InChI=1/C43H70N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-34(52)71-27-26-45-33(51)24-25-46-41(55)38(54)43(2,3)29-64-70(61,62)67-69(59,60)63-28-32-37(66-68(56,57)58)36(53)42(65-32)50-31-49-35-39(44)47-30-48-40(35)50/h8-9,11-12,14-15,17-18,30-32,36-38,42,53-54H,4-7,10,13,16,19-29H2,1-3H3,(H,45,51)(H,46,55)(H,59,60)(H,61,62)(H2,44,47,48)(H2,56,57,58)/b9-8-,12-11-,15-14-,18-17-/t32-,36-,37-,38?,42-/m1/s1
initial amount: NaN
boundary condition: false
is: SBO:0000247
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110061#_1e13e7cc_c437_4582_a122_2a48d443ad18
constant: false
type: Species
initial amount: NaN
is encoded by: hsa:215
is: SBO:0000252
name: ABCD1
is: P33897
initial concentration: NaN
has only substance units: false
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110061#_ab4d8fe2_42e5_4e9c_9d9f_f4c8da8983f3
name: ACSS2
type: Species
is: SBO:0000252
initial amount: NaN
constant: false
is: Q5QPH3
boundary condition: true
has only substance units: false
initial concentration: NaN
is encoded by: hsa:55902

metaR PMTCOAtx
name: fatty acid intracellular transport
is: SBO:0000185
reactant: MODEL1310110061#
type: Reaction
kinetic law: MODEL1310110061#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: NOTES:interaction between peroxisomes and ER (some enzymes on the outer membrane) NJ
is described by: ECO:0000000
reversible: true
product: MODEL1310110061#
fast: false

metaM atp e
name: ATP(4-)
is: SBO:0000247
constant: false
is: C00002
is: HMDB00538
type: Species
initial amount: NaN
boundary condition: false
initial concentration: 1.0
has only substance units: false
is: CHEBI:57299

metaM 4izp c
constant: false
is: SBO:0000247
type: Species
is: CHEBI:57255
is: HMDB01014
notes: FORMULA: C6H7N2O3 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC01157 EHMN_ABBREVIATION: C03680
name: 4-Imidazolone-5-propanoate
initial concentration: 1.0
has only substance units: false
initial amount: NaN
boundary condition: false

metaM cholcoa c
constant: false
is: CHEBI:57373
name: choloyl-CoA(4-)
initial concentration: 1.0
initial amount: NaN
notes: FORMULA: C45H70N7O20P3S CHARGE: -4 INCHI: InChI=1S/C45H74N7O20P3S/c1-23(26-7-8-27-34-28(18-31(55)45(26,27)5)44(4)12-10-25(53)16-24(44)17-29(34)54)6-9-33(57)76-15-14-47-32(56)11-13-48-41(60)38(59)43(2,3)20-69-75(66,67)72-74(64,65)68-19-30-37(71-73(61,62)63)36(58)42(70-30)52-22-51-35-39(46)49-21-50-40(35)52/h21-31,34,36-38,42,53-55,58-59H,6-20H2,1-5H3,(H,47,56)(H,48,60)(H,64,65)(H,66,67)(H2,46,49,50)(H2,61,62,63)/p-4/t23-,24+,25-,26-,27+,28+,29-,30-,31+,34+,36-,37-,38+,42-,44+,45-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00844 EHMN_ABBREVIATION: C01794
is: HMDB01374
boundary condition: false
is: SBO:0000247
has only substance units: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110061#_fe5da2b8_adfb_496f_8bc6_be709edc7314
is: O15357
is encoded by: hsa:3636
has only substance units: false
is: SBO:0000252
name: INPPL1
constant: false
initial concentration: NaN
boundary condition: true
type: Species
initial amount: NaN

metaR FACOAL1821
reversible: true
product: MODEL1310110061#
notes: GENE_ASSOCIATION: (2180.1) SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 4 AUTHORS: PMID:15292367 NOTES:NJ, RE1514C
reactant: MODEL1310110061#
is described by: ECO:0000269
type: Reaction
fast: false
name: fatty-acid--CoA ligase
is: SBO:0000176
kinetic law: MODEL1310110061#
is version of: http://identifiers.org/ec-code/6.2.1.3
modifier: MODEL1310110061#

metaM HC10852 r
type: Species
is: CHEBI:61540
is: SBO:0000247
constant: false
has only substance units: false
initial concentration: 1.0
initial amount: NaN
boundary condition: false
notes: FORMULA: C37H60N7O17P3S CHARGE: -4 INCHI: InChI=1S/C37H64N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-28(46)65-21-20-39-27(45)18-19-40-35(49)32(48)37(2,3)23-58-64(55,56)61-63(53,54)57-22-26-31(60-62(50,51)52)30(47)36(59-26)44-25-43-29-33(38)41-24-42-34(29)44/h9-10,24-26,30-32,36,47-48H,4-8,11-23H2,1-3H3,(H,39,45)(H,40,49)(H,53,54)(H,55,56)(H2,38,41,42)(H2,50,51,52)/p-4/b10-9-/t26-,30-,31-,32+,36-/m1/s1 EHMN_ABBREVIATION: CE0852
name: palmitoleyl-CoA(4-)

metaM dec24dicoa m
boundary condition: false
type: Species
is: HMDB01168
constant: false
is: SBO:0000247
initial amount: NaN
initial concentration: 1.0
notes: FORMULA: C31H46N7O17P3S CHARGE: -4
name: 2,4-decadienoylcoa
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110061#_0430be30_c06a_4e4d_bd55_c8529cc1965b
is: Q9NVE7
is: SBO:0000252
has only substance units: false
initial concentration: NaN
boundary condition: true
initial amount: NaN
type: Species
constant: false
name: PANK4
is encoded by: hsa:55229

metaM hedepecoa m
constant: false
notes: FORMULA: C37H52N7O17P3S CHARGE: -4
initial concentration: 1.0
initial amount: NaN
is: HMDB02288
boundary condition: false
has only substance units: false
name: 2,4,7,10,13-hexadecapentenoylcoa
is: SBO:0000247
type: Species

metaM odecoa c
boundary condition: false
type: Species
is: SBO:0000247
name: Octadecenoyl-CoA (n-C18:1CoA)
initial concentration: 1.0
has only substance units: false
notes: FORMULA: C39H64N7O17P3S CHARGE: -4
constant: false
is: HMDB01322
is: CHEBI:3793
initial amount: NaN

metaR Htg
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 2 AUTHORS: NOTES:
is: SBO:0000185
is described by: ECO:0000000
reactant: MODEL1310110061#
name: proton diffusion (Golgi)
kinetic law: MODEL1310110061#
type: Reaction
reversible: true
product: MODEL1310110061#
fast: false

metaM HC00319 m
type: Species
constant: false
is: CHEBI:30794
notes: FORMULA: C3H2O4 CHARGE: -2 INCHI: InChI=1S/C3H4O4/c4-2(5)1-3(6)7/h1H2,(H,4,5)(H,6,7)
is: SBO:0000247
initial amount: NaN
initial concentration: 1.0
name: Malonate
has only substance units: false
boundary condition: false

metaM dc2coa m
initial concentration: 1.0
is: CHEBI:61406
type: Species
initial amount: NaN
constant: false
notes: FORMULA: C31H48N7O17P3S CHARGE: -4 EHMN_ABBREVIATION: C05275
has only substance units: false
boundary condition: false
is: SBO:0000247
name: trans-Dec-2-enoyl-CoA

metaR r2341
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
is: SBO:0000185
reversible: true
reactant: MODEL1310110061#
name: Organic anion transporter 5 Utilized transport
is described by: ECO:0000000
type: Reaction
product: MODEL1310110061#
fast: false
kinetic law: MODEL1310110061#

http://identifiers.org/biomodels.db/MODEL1310110061#_729b8f9c_622a_46ca_80ca_f5380fc06b68
has only substance units: false
is: SBO:0000252
boundary condition: true
initial amount: NaN
is encoded by: hsa:AI684467
initial concentration: NaN
name: _AI684467_1_m
type: Species
constant: false

http://identifiers.org/biomodels.db/MODEL1310110061#_37578e7d_7c54_49de_86fc_15cddf95e315
name: SLC7A1
is: P30825
type: Species
initial amount: NaN
is encoded by: hsa:6541
boundary condition: true
constant: false
initial concentration: NaN
is: SBO:0000252
has only substance units: false

metaM 34dhoxmand m
type: Species
notes: FORMULA: C8H7O5 CHARGE: -1 INCHI: InChI=1S/C8H8O5/c9-5-2-1-4(3-6(5)10)7(11)8(12)13/h1-3,7,9-11H,(H,12,13) HEPATONET_1.0_ABBREVIATION: HC01517 EHMN_ABBREVIATION: C05580
is: CHEBI:27637
initial concentration: 1.0
name: 3,4-Dihydroxymandelate
initial amount: NaN
constant: false
has only substance units: false
is: SBO:0000247
is: HMDB01866
boundary condition: false

metaM dgchol c
is: CHEBI:36252
name: glycochenodeoxycholate
boundary condition: false
notes: FORMULA: C26H43NO5 CHARGE: 0 INCHI: InChI=1S/C26H43NO5/c1-15(4-7-22(30)27-14-23(31)32)18-5-6-19-24-20(9-11-26(18,19)3)25(2)10-8-17(28)12-16(25)13-21(24)29/h15-21,24,28-29H,4-14H2,1-3H3,(H,27,30)(H,31,32)/p-1/t15-,16+,17-,18-,19+,20+,21-,24+,25+,26-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01472
initial amount: NaN
initial concentration: 1.0
has only substance units: false
constant: false
is: SBO:0000247
is: HMDB00637
type: Species

http://identifiers.org/biomodels.db/MODEL1310110061#_61a0975d_386d_4325_a5aa_521eec929e5f
has only substance units: false
is: SBO:0000252
is encoded by: hsa:56954
constant: false
boundary condition: true
is: Q9NQR4
type: Species
initial amount: NaN
initial concentration: NaN
name: NIT2

metaR PRODt2r
is: SBO:0000185
reactant: MODEL1310110061#
kinetic law: MODEL1310110061#
name: D-proline reversible transport via proton symport
modifier: MODEL1310110061#
product: MODEL1310110061#
notes: GENE_ASSOCIATION: (206358.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11390972,PMID:11959859 NOTES:NCD SAB D form
fast: false
type: Reaction
is described by: ECO:0000304
reversible: true

metaM fru e
initial concentration: 1.0
has only substance units: false
notes: FORMULA: C6H12O6 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00097 EHMN_ABBREVIATION: C00095
boundary condition: false
type: Species
constant: false
is: C00095
is: HMDB00660
name: D-Fructose
is: SBO:0000247
is: CHEBI:15824
initial amount: NaN

metaM ps hs c
constant: false
type: Species
name: ps_hs[c]
boundary condition: false
is: SBO:0000247
initial concentration: 1.0
has only substance units: false
initial amount: NaN
is: CHEBI:18303
notes: FORMULA: C6H11NO6PFULLRCO2FULLR2CO2 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC02006

metaM fe3 e
is: HMDB12943
constant: false
has only substance units: false
initial concentration: 1.0
initial amount: NaN
is: SBO:0000247
type: Species
boundary condition: false
is: CHEBI:29034
name: Fe3+
notes: FORMULA: Fe CHARGE: 3 HEPATONET_1.0_ABBREVIATION: HC01847

metaM Ser Thr g
notes: FORMULA: XH CHARGE: 0
constant: false
name: protein-linked serine or threonine residue (O-glycosylation site)
initial concentration: 1.0
has only substance units: false
is: HMDB00143
type: Species
boundary condition: false
is: C00124
is: SBO:0000247
is: CHEBI:0
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110061#_14e09ebb_4659_4acb_adb8_a44ab4563ce6
initial amount: NaN
initial concentration: NaN
is: SBO:0000252
name: PRPS2
type: Species
boundary condition: true
is: P11908
constant: false
has only substance units: false
is encoded by: hsa:5634

metaR r2133
is: SBO:0000185
type: Reaction
product: MODEL1310110061#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
kinetic law: MODEL1310110061#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
modifier: MODEL1310110061#
is described by: ECO:0000000
fast: false
reversible: true
reactant: MODEL1310110061#

http://identifiers.org/biomodels.db/MODEL1310110061#_919a637f_455b_4f89_b211_fad1d622faf4
boundary condition: true
initial concentration: NaN
is: SBO:0000252
type: Species
is encoded by: hsa:2876
constant: false
name: GPX1
has only substance units: false
initial amount: NaN

metaR UGLCNACtg
type: Reaction
kinetic law: MODEL1310110061#
notes: GENE_ASSOCIATION: (11046.1) SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 4 AUTHORS: PMID:15082721,PMID:15607426 NOTES:NCD
fast: false
name: UDP-GlcNAc Golgi transport via CMP antiport
product: MODEL1310110061#
reactant: MODEL1310110061#
reversible: true
is: SBO:0000185
is described by: ECO:0000269
modifier: MODEL1310110061#

http://identifiers.org/biomodels.db/MODEL1310110061#_3f6317bc_6fb3_4c5d_96f2_4d49c09e83a1
boundary condition: true
constant: false
initial concentration: NaN
is: SBO:0000252
has only substance units: false
is encoded by: hsa:10637
name: LEFTY1
type: Species
initial amount: NaN
is: O75610

metaM vacccoa c
notes: FORMULA: C39H64N7O17P3S CHARGE: -4 INCHI: InChI=1/C39H68N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-30(48)67-23-22-41-29(47)20-21-42-37(51)34(50)39(2,3)25-60-66(57,58)63-65(55,56)59-24-28-33(62-64(52,53)54)32(49)38(61-28)46-27-45-31-35(40)43-26-44-36(31)46/h9-10,26-28,32-34,38,49-50H,4-8,11-25H2,1-3H3,(H,41,47)(H,42,51)(H,55,56)(H,57,58)(H2,40,43,44)(H2,52,53,54)/b10-9+/t28-,32-,33?,34+,38-/m1/s1
constant: false
is: SBO:0000247
type: Species
initial concentration: 1.0
has only substance units: false
initial amount: NaN
name: vaccenyl coenzyme A
is: http://identifiers.org/pubchem.compound/9543677
boundary condition: false
is: HMDB06521

metaR TETPENT6COAtx
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 0 AUTHORS: NOTES:interaction between peroxisomes and ER (some enzymes on the outer membrane) NJ
reversible: true
name: fatty acid intracellular transport
product: MODEL1310110061#
is described by: ECO:0000000
is: SBO:0000185
fast: false
type: Reaction
kinetic law: MODEL1310110061#
reactant: MODEL1310110061#

http://identifiers.org/biomodels.db/MODEL1310110061#_29db234f_b3ed_4149_af7a_068a9a990a76
is: Q6FGQ4
type: Species
is encoded by: hsa:5538
boundary condition: true
initial amount: NaN
is: SBO:0000252
has only substance units: false
name: PPT1
constant: false
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110061#_e1d808be_0764_4254_a155_4769dbb78f5c
initial amount: NaN
boundary condition: true
has only substance units: false
is encoded by: hsa:7378
is: SBO:0000252
constant: false
name: UPP1
initial concentration: NaN
type: Species

http://identifiers.org/biomodels.db/MODEL1310110061#_2d2646f9_5a95_48a8_bb79_50f866dd73c8
initial amount: NaN
boundary condition: true
type: Species
has only substance units: false
is encoded by: hsa:9107
is: SBO:0000252
name: MTMR6
constant: false
is: Q9Y217
initial concentration: NaN

metaM hdcea c
constant: false
notes: FORMULA: C16H29O2 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC01981 EHMN_ABBREVIATION: CE0850
is: CHEBI:32372
name: Hexadecenoate (n-C16:1)
has only substance units: false
is: HMDB03229
type: Species
boundary condition: false
initial concentration: 1.0
initial amount: NaN
is: SBO:0000247

metaM gam e
boundary condition: false
notes: FORMULA: C6H14NO5 CHARGE: 1 HEPATONET_1.0_ABBREVIATION: HC00279 EHMN_ABBREVIATION: C00329
is: CHEBI:17315
is: C00329
has only substance units: false
is: SBO:0000247
initial amount: NaN
initial concentration: 1.0
name: D-Glucosamine
type: Species
is: HMDB01514
constant: false

http://identifiers.org/biomodels.db/MODEL1310110061#_2c20a682_a3ff_48ea_bc54_0c5bc5534511
is: P47895
type: Species
is: SBO:0000252
initial concentration: NaN
boundary condition: true
initial amount: NaN
has only substance units: false
is encoded by: hsa:220
constant: false
name: ALDH1A3

metaM for r
initial concentration: 1.0
constant: false
is: HMDB00142
is: SBO:0000247
type: Species
notes: FORMULA: CH1O2 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00061 EHMN_ABBREVIATION: C00058
is: CHEBI:15740
has only substance units: false
boundary condition: false
initial amount: NaN
name: Formate
is: C00058

metaR HIStN1
modifier: MODEL1310110061#
name: Histidine transport (Na, H coupled)
kinetic law: MODEL1310110061#
is: SBO:0000185
reactant: MODEL1310110061#
fast: false
is described by: ECO:0000269
type: Reaction
notes: GENE_ASSOCIATION: (10991.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10823827,PMID:12845534 NOTES:SAB based om PMID 10823827
reversible: true
product: MODEL1310110061#

http://identifiers.org/biomodels.db/MODEL1310110061#_d4fdac56_ee63_446e_88ca_52730f1545cc
type: Species
name: SLC29A1
is: Q99808
initial concentration: NaN
is: SBO:0000252
boundary condition: true
is encoded by: hsa:2030
has only substance units: false
initial amount: NaN
constant: false

metaR COQ3m
name: methyltransferase COQ3
modifier: MODEL1310110061#
reversible: false
kinetic law: MODEL1310110061#
reactant: MODEL1310110061#
is version of: http://identifiers.org/ec-code/2.1.1.114
type: Reaction
is: SBO:0000176
is described by: ECO:0000269
fast: false
product: MODEL1310110061#
notes: GENE_ASSOCIATION: (51805.1) SUBSYSTEM: Ubiquinone synthesis EC Number: Confidence Level: 4 AUTHORS: PMID:10777520,PMID:11051212,PMID:1965190,PMID:7380842 NOTES:_2.1.1.114 IT

http://identifiers.org/biomodels.db/MODEL1310110061#_f6a11557_c9a3_4889_bcdb_2adf692fd208
is encoded by: hsa:2746
is: SBO:0000252
has only substance units: false
name: GLUD1
boundary condition: true
constant: false
type: Species
initial concentration: NaN
is: E9KL48
initial amount: NaN

metaR RE3272N
notes: GENE_ASSOCIATION: SUBSYSTEM: Phosphatidylinositol phosphate metabolism EC Number: 3.1.3.66 Confidence Level: 0 AUTHORS: PMID:7556092 NOTES:
reversible: true
is described by: ECO:0000000
product: MODEL1310110061#
fast: false
name: RE3272
is: SBO:0000176
kinetic law: MODEL1310110061#
reactant: MODEL1310110061#
type: Reaction

metaR r2132
reversible: true
reactant: MODEL1310110061#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
modifier: MODEL1310110061#
type: Reaction
product: MODEL1310110061#
fast: false
kinetic law: MODEL1310110061#
is: SBO:0000185
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
is described by: ECO:0000000

metaR A MANASEly
reactant: MODEL1310110061#
is version of: http://identifiers.org/ec-code/3.2.1.24
is: SBO:0000176
type: Reaction
modifier: MODEL1310110061#
fast: false
product: MODEL1310110061#
is described by: ECO:0000000
kinetic law: MODEL1310110061#
notes: GENE_ASSOCIATION: (4125.1) SUBSYSTEM: N-glycan degradation EC Number: 3.2.1.24 Confidence Level: 0 AUTHORS: PMID:8910458 NOTES:NCD
name: alpha-mannosidase, lysosomal
reversible: false

metaM Rtotal2 e
type: Species
is: HMDB00244
boundary condition: false
initial amount: NaN
is: C00255
notes: FORMULA: CO2FULLR2 CHARGE: -1
has only substance units: false
is: SBO:0000247
initial concentration: 1.0
name: R total 2 position
constant: false
is: CHEBI:3554

metaR r2401
reactant: MODEL1310110061#
reversible: false
name: Mitochondrial Carrier (MC) TCDB:2.A.29.19.1
type: Reaction
is: SBO:0000185
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172 NOTES:
product: MODEL1310110061#
kinetic law: MODEL1310110061#
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110061#_fbb69a1d_21f6_46e2_80b4_12c36468d0c8
boundary condition: true
is: SBO:0000252
constant: false
name: RRM2
is: P31350
is encoded by: hsa:6241
initial concentration: NaN
has only substance units: false
initial amount: NaN
type: Species

metaR GLCt2 2
is: SBO:0000185
is described by: ECO:0000269
modifier: MODEL1310110061#
kinetic law: MODEL1310110061#
notes: GENE_ASSOCIATION: (6523.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:11024018,PMID:11034615,PMID:12748858,PMID:2490366,PMID:8063771 NOTES:
fast: false
reversible: true
product: MODEL1310110061#
reactant: MODEL1310110061#
type: Reaction
name: D-glucose transport in via proton symport

metaR PI4PLCn
notes: GENE_ASSOCIATION: (23236.2) or (23236.1) SUBSYSTEM: Inositol phosphate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:10760467,PMID:11118617,PMID:12213492 NOTES:NCD
type: Reaction
is version of: http://identifiers.org/ec-code/3.1.4.11
fast: false
is: SBO:0000176
modifier: MODEL1310110061#
is described by: ECO:0000269
reversible: false
name: phosphatidylinositol 4-phosphate phospholipase C, nucleus
reactant: MODEL1310110061#
kinetic law: MODEL1310110061#
product: MODEL1310110061#

metaM HC02202 e
notes: FORMULA: C20H31O4 CHARGE: -1 INCHI: InChI=1S/C20H32O4/c1-2-3-6-9-17(21)14-12-16-13-15-19(22)18(16)10-7-4-5-8-11-20(23)24/h12-18,21H,2-11H2,1H3,(H,23,24)/p-1/b14-12+/t16-,17-,18+/m0/s1 EHMN_ABBREVIATION: C04685
boundary condition: false
name: prostaglandin A1(1-)
type: Species
is: CHEBI:57398
initial amount: NaN
initial concentration: 1.0
has only substance units: false
constant: false
is: SBO:0000247

metaM dnad c
is: SBO:0000247
is: HMDB01179
is: C00857
name: Deamino-NAD+
boundary condition: false
type: Species
is: CHEBI:18304
notes: FORMULA: C21H24N6O15P2 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00564 EHMN_ABBREVIATION: C00857
has only substance units: false
initial amount: NaN
initial concentration: 1.0
constant: false

metaR ILETAm
type: Reaction
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/2.6.1.42
fast: false
name: isoleucine transaminase, mitochondrial
kinetic law: MODEL1310110061#
notes: GENE_ASSOCIATION: (587.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 2.6.1.42 Confidence Level: 4 AUTHORS: PMID:6933702,PMID:9165094 NOTES:NCD
reversible: true
modifier: MODEL1310110061#
is: SBO:0000176
product: MODEL1310110061#
reactant: MODEL1310110061#

http://identifiers.org/biomodels.db/MODEL1310110061#_c0d4bc32_69ab_437a_94c3_0ad00b9d79ee
has only substance units: false
initial amount: NaN
type: Species
constant: false
initial concentration: NaN
is encoded by: hsa:353
is: P07741
is: SBO:0000252
name: APRT
boundary condition: true

metaR EX duri LPAREN e RPAREN
kinetic law: MODEL1310110061#
reactant: MODEL1310110061#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for Deoxyuridine
type: Reaction

metaM ps hs m
constant: false
has only substance units: false
boundary condition: false
notes: FORMULA: C6H11NO6PFULLRCO2FULLR2CO2 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC02006
is: SBO:0000247
is: CHEBI:18303
initial amount: NaN
initial concentration: 1.0
type: Species
name: ps_hs[m]

metaM HC01609 e
type: Species
is: SBO:0000247
notes: FORMULA: C40H36N4O16 CHARGE: -8 INCHI: InChI=1S/C40H44N4O16/c45-33(46)5-1-17-21(9-37(53)54)29-14-26-19(3-7-35(49)50)23(11-39(57)58)31(43-26)16-28-20(4-8-36(51)52)24(12-40(59)60)32(44-28)15-27-18(2-6-34(47)48)22(10-38(55)56)30(42-27)13-25(17)41-29/h41-44H,1-16H2,(H,45,46)(H,47,48)(H,49,50)(H,51,52)(H,53,54)(H,55,56)(H,57,58)(H,59,60) EHMN_ABBREVIATION: C05766
initial concentration: 1.0
name: UroporphyrinogenI
initial amount: NaN
has only substance units: false
boundary condition: false
is: CHEBI:28766
constant: false

metaR LEUKTRA4tr
reactant: MODEL1310110061#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: NOTES:unknown mechanism, presumed diffusion NJ
is: SBO:0000185
product: MODEL1310110061#
name: leukotriene intracellular transport
type: Reaction
is described by: ECO:0000000
fast: false
reversible: true
kinetic law: MODEL1310110061#

metaR FACOAL184
fast: false
reversible: true
is version of: http://identifiers.org/ec-code/6.2.1.3
product: MODEL1310110061#
type: Reaction
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (2180.1) SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 4 AUTHORS: PMID:15292367 NOTES:NJ
name: fatty-acid--CoA ligase
modifier: MODEL1310110061#
kinetic law: MODEL1310110061#
reactant: MODEL1310110061#
is: SBO:0000176

metaR r1612
is described by: ECO:0000000
fast: false
kinetic law: MODEL1310110061#
notes: GENE_ASSOCIATION: (19.1) or (AL038231.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
product: MODEL1310110061#
is: SBO:0000185
modifier: MODEL1310110061#
reversible: true
type: Reaction
reactant: MODEL1310110061#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1

http://identifiers.org/biomodels.db/MODEL1310110061#_6f96c7d8_c21b_494c_976b_e10bf94bd51a
type: Species
name: SLC6A7
initial amount: NaN
is: SBO:0000252
has only substance units: false
constant: false
initial concentration: NaN
is: Q99884
boundary condition: true
is encoded by: hsa:6534

metaR TYROXDAc
product: MODEL1310110061#
is: SBO:0000176
modifier: MODEL1310110061#
is described by: ECO:0000269
kinetic law: MODEL1310110061#
reversible: false
name: Tyramine:oxygen oxidoreductase(deaminating)(flavin-containing) (cytosol)
notes: GENE_ASSOCIATION: (4128.1) or (4129.1) SUBSYSTEM: Tyrosine metabolism EC Number: 1.4.3.6 Confidence Level: 4 AUTHORS: PMID:11336106,PMID:14697899,PMID:8255365 NOTES:SAB also 1.4.3.4
fast: false
type: Reaction
is version of: http://identifiers.org/ec-code/1.4.3.4
reactant: MODEL1310110061#

http://identifiers.org/biomodels.db/MODEL1310110061#_79efc9d5_b1dc_41e4_96bf_d99f1ae35b71
boundary condition: true
is: SBO:0000252
initial amount: NaN
initial concentration: NaN
constant: false
name: GGT1
is: P19440
type: Species
is encoded by: hsa:2678
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110061#_ca414673_21e1_4294_9a96_2645530f2ffa
initial concentration: NaN
is: P27144
boundary condition: true
name: AK4
initial amount: NaN
is: SBO:0000252
is encoded by: hsa:205
has only substance units: false
type: Species
constant: false

http://identifiers.org/biomodels.db/MODEL1310110061#_7ceca658_8598_4c6d_87cf_4e9a15c6747b
initial amount: NaN
constant: false
type: Species
name: NMNAT2
has only substance units: false
initial concentration: NaN
boundary condition: true
is: SBO:0000252
is: Q9BZQ4
is encoded by: hsa:23057

metaM co2 m
initial concentration: 1.0
boundary condition: false
is: CHEBI:16526
notes: FORMULA: CO2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00021 EHMN_ABBREVIATION: C00011
initial amount: NaN
is: C00011
constant: false
is: SBO:0000247
is: HMDB01967
name: CO2
has only substance units: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110061#_391a1fe5_f370_41fc_a6c3_47b42b159eb8
initial amount: NaN
has part: B3KT19
initial concentration: NaN
boundary condition: true
name: PIK3CB:PIK3R1
is encoded by: hsa:5291
is: SBO:0000297
constant: false
type: Species
has only substance units: false
has part: B4DER4
is encoded by: hsa:5295

metaR r2131
kinetic law: MODEL1310110061#
fast: false
type: Reaction
modifier: MODEL1310110061#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
reversible: true
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
reactant: MODEL1310110061#
is: SBO:0000185
product: MODEL1310110061#

metaM gdp c
is: C00035
has only substance units: false
notes: FORMULA: C10H12N5O11P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00043 EHMN_ABBREVIATION: C00035
constant: false
initial concentration: 1.0
is: SBO:0000247
is: HMDB01201
boundary condition: false
type: Species
initial amount: NaN
is: CHEBI:58189
name: GDP

http://identifiers.org/biomodels.db/MODEL1310110061#_e29578f5_cf33_4d4f_8a68_150518be998c
is encoded by: hsa:51196
initial amount: NaN
is: SBO:0000252
boundary condition: true
is: Q9P212
constant: false
type: Species
name: PLCE1
initial concentration: NaN
has only substance units: false

metaM atp r
is: HMDB00538
name: ATP(4-)
is: CHEBI:57299
is: C00002
constant: false
type: Species
has only substance units: false
initial amount: NaN
initial concentration: 1.0
boundary condition: false
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110061#_8a835af2_74a5_4a59_8e5c_cd4ebeb2d8a1
is: SBO:0000252
type: Species
constant: false
is: P09923
has only substance units: false
boundary condition: true
is encoded by: hsa:248
initial concentration: NaN
name: ALPI
initial amount: NaN

metaM dudp c
type: Species
is: HMDB01000
initial amount: NaN
name: dUDP
is: C01346
is: CHEBI:60471
is: SBO:0000247
constant: false
boundary condition: false
has only substance units: false
notes: FORMULA: C9H11N2O11P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00768 EHMN_ABBREVIATION: C01346
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110061#_2fd03191_ee12_40a9_9e21_92d6162f017f
is: SBO:0000252
is encoded by: hsa:5052
has only substance units: false
type: Species
name: PRDX1
constant: false
initial concentration: NaN
boundary condition: true
initial amount: NaN

metaM nrvnccoa c
name: nervonyl coenzyme A
boundary condition: false
initial concentration: 1.0
initial amount: NaN
is: SBO:0000247
type: Species
has only substance units: false
constant: false
notes: FORMULA: C45H76N7O17P3S CHARGE: -4 INCHI: InChI=1/C45H80N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-24-25-36(54)73-29-28-47-35(53)26-27-48-43(57)40(56)45(2,3)31-66-72(63,64)69-71(61,62)65-30-34-39(68-70(58,59)60)38(55)44(67-34)52-33-51-37-41(46)49-32-50-42(37)52/h11-12,32-34,38-40,44,55-56H,4-10,13-31H2,1-3H3,(H,47,53)(H,48,57)(H,61,62)(H,63,64)(H2,46,49,50)(H2,58,59,60)/b12-11-/t34-,38-,39-,40?,44-/m1/s1
is: C16532

metaM dgchol e
type: Species
boundary condition: false
notes: FORMULA: C26H43NO5 CHARGE: 0 INCHI: InChI=1S/C26H43NO5/c1-15(4-7-22(30)27-14-23(31)32)18-5-6-19-24-20(9-11-26(18,19)3)25(2)10-8-17(28)12-16(25)13-21(24)29/h15-21,24,28-29H,4-14H2,1-3H3,(H,27,30)(H,31,32)/p-1/t15-,16+,17-,18-,19+,20+,21-,24+,25+,26-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01472
name: glycochenodeoxycholate
is: HMDB00637
is: CHEBI:36252
is: SBO:0000247
has only substance units: false
initial amount: NaN
initial concentration: 1.0
constant: false

metaR ABTti
name: L-arabinitol transport via passive diffusion
fast: false
reactant: MODEL1310110061#
reversible: false
kinetic law: MODEL1310110061#
is described by: ECO:0000000
product: MODEL1310110061#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:15234337 NOTES:NCD
type: Reaction
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110061#_3aca6ad0_d428_4a5b_983f_b432113fe7f3
constant: false
type: Species
name: AK4
has only substance units: false
is: SBO:0000252
initial amount: NaN
initial concentration: NaN
boundary condition: true
is encoded by: hsa:205

metaM dag hs c
has only substance units: false
notes: FORMULA: C3H6OFULLRCO2FULLR2CO2 CHARGE: 0
constant: false
type: Species
boundary condition: false
is: SBO:0000247
is: CHEBI:18035
initial concentration: 1.0
initial amount: NaN
name: diglyceride

http://identifiers.org/biomodels.db/MODEL1310110061#_32b4fb6e_5379_44c4_8d6a_8cfdbb51c1e1
constant: false
is: SBO:0000252
initial amount: NaN
name: ACAT2
boundary condition: true
is encoded by: hsa:39
is: Q9BWD1
has only substance units: false
initial concentration: NaN
type: Species

metaR r1611
is: SBO:0000185
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
type: Reaction
kinetic law: MODEL1310110061#
product: MODEL1310110061#
reversible: true
fast: false
reactant: MODEL1310110061#
is described by: ECO:0000000

metaM tdchola e
type: Species
boundary condition: false
is: CHEBI:9407
initial amount: NaN
initial concentration: 1.0
is: SBO:0000247
constant: false
notes: FORMULA: C26H45NO6S CHARGE: 0 INCHI: InChI=1S/C26H45NO6S/c1-16(4-7-23(30)27-12-13-34(31,32)33)19-5-6-20-24-21(9-11-26(19,20)3)25(2)10-8-18(28)14-17(25)15-22(24)29/h16-22,24,28-29H,4-15H2,1-3H3,(H,27,30)(H,31,32,33)/p-1/t16-,17+,18-,19-,20+,21+,22-,24+,25+,26-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01471 EHMN_ABBREVIATION: C05465
name: taurochenodeoxycholate
has only substance units: false
is: HMDB00951

metaR RE3269C
fast: false
reversible: true
notes: GENE_ASSOCIATION: (8897.1) or (8897.3) or (8897.2) SUBSYSTEM: Phosphatidylinositol phosphate metabolism EC Number: 3.1.3.66 Confidence Level: 0 AUTHORS: PMID:7556092 NOTES:Recin 1 had irreversible version - PI35P3P - GPR from PI35P3P was added - May 2011 IT
is described by: ECO:0000000
product: MODEL1310110061#
name: RE3269
is: SBO:0000176
type: Reaction
reactant: MODEL1310110061#
kinetic law: MODEL1310110061#
is version of: http://identifiers.org/ec-code/3.1.3.48
modifier: MODEL1310110061#

http://identifiers.org/biomodels.db/MODEL1310110061#_d9294475_c628_47d6_93aa_e790e579d65a
is: SBO:0000252
type: Species
is encoded by: hsa:2936
name: GSR
has only substance units: false
boundary condition: true
is: P00390
initial concentration: NaN
constant: false
initial amount: NaN

metaR FUT34g
notes: GENE_ASSOCIATION: (2525.1) SUBSYSTEM: Blood group synthesis EC Number: 2.4.1.65 Confidence Level: 4 AUTHORS: PMID:12424536,PMID:12493760,PMID:1977660 NOTES:NJ
product: MODEL1310110061#
is version of: http://identifiers.org/ec-code/2.4.1.65
is: SBO:0000176
type: Reaction
fast: false
reactant: MODEL1310110061#
name: fucosyltransferase 3 (galactoside 3(4)-L-fucosyltransferase, Lewis blood group included) 1
modifier: MODEL1310110061#
kinetic law: MODEL1310110061#
reversible: false
is described by: ECO:0000269

http://identifiers.org/biomodels.db/MODEL1310110061#_d44a4137_d340_413e_94de_1d1596a727f5
has part: P31040
is encoded by: hsa:6390
constant: false
is encoded by: hsa:6392
is encoded by: hsa:6389
boundary condition: true
has only substance units: false
has part: P21912
has part: O14521
is encoded by: hsa:6391
initial amount: NaN
is: SBO:0000297
initial concentration: NaN
has part: Q99643
type: Species
name: SDHA:SDHB:SDHC:SDHD

metaR FACOAL260
is: SBO:0000176
modifier: MODEL1310110061#
fast: false
is described by: ECO:0000000
reversible: true
is version of: http://identifiers.org/ec-code/6.2.1.3
notes: GENE_ASSOCIATION: (2180.1) SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 4 AUTHORS: PMID:15292367 NOTES:cytoplasmic version -NJ
kinetic law: MODEL1310110061#
type: Reaction
reactant: MODEL1310110061#
product: MODEL1310110061#
name: fatty-acid--CoA ligase (n-C26:0)

metaR r1377
kinetic law: MODEL1310110061#
type: Reaction
name: S-(hydroxymethyl)glutathione synthase Methane metabolism EC:4.4.1.22
is described by: ECO:0000000
product: MODEL1310110061#
fast: false
reversible: true
reactant: MODEL1310110061#
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 4.4.1.22 Confidence Level: 0 AUTHORS: NOTES:
is: SBO:0000176

metaM cmp n
name: CMP(2-)
is: SBO:0000247
initial concentration: 1.0
boundary condition: false
type: Species
is: HMDB00095
has only substance units: false
notes: FORMULA: C9H12N3O8P CHARGE: -2 INCHI: InChI=1S/C9H14N3O8P/c10-5-1-2-12(9(15)11-5)8-7(14)6(13)4(20-8)3-19-21(16,17)18/h1-2,4,6-8,13-14H,3H2,(H2,10,11,15)(H2,16,17,18)/p-2/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00060 EHMN_ABBREVIATION: C00055
initial amount: NaN
is: CHEBI:60377
constant: false

metaM prostgd2 r
notes: FORMULA: C20H31O5 CHARGE: -1 INCHI: InChI=1S/C20H32O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h4,7,12-13,15-18,21-22H,2-3,5-6,8-11,14H2,1H3,(H,24,25)/p-1/b7-4-,13-12+/t15-,16+,17+,18-/m0/s1 EHMN_ABBREVIATION: C00696
is: HMDB01403
boundary condition: false
initial amount: NaN
name: prostaglandin D2(1-)
initial concentration: 1.0
constant: false
type: Species
is: CHEBI:57406
has only substance units: false
is: SBO:0000247

metaR r2130
modifier: MODEL1310110061#
reactant: MODEL1310110061#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
product: MODEL1310110061#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
kinetic law: MODEL1310110061#
type: Reaction
is: SBO:0000185
reversible: true
is described by: ECO:0000000
fast: false

metaR EX fol LPAREN e RPAREN
kinetic law: MODEL1310110061#
reactant: MODEL1310110061#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for Folate
type: Reaction

metaR r1932
reversible: false
is described by: ECO:0000000
type: Reaction
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
name: Y+LAT2 Utilized transport
kinetic law: MODEL1310110061#
modifier: MODEL1310110061#
product: MODEL1310110061#
reactant: MODEL1310110061#
is: SBO:0000185
fast: false

http://identifiers.org/biomodels.db/MODEL1310110061#_bc347f22_a5cc_41e0_ac2c_5b91244a4785
type: Species
initial amount: NaN
has only substance units: false
constant: false
is: Q9Y617
boundary condition: true
name: PSAT1
is: SBO:0000252
initial concentration: NaN
is encoded by: hsa:29968

metaR GALtly
is: SBO:0000185
product: MODEL1310110061#
is described by: ECO:0000000
kinetic law: MODEL1310110061#
reversible: false
name: galactose efflux from lysosome
fast: false
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 2 AUTHORS: PMID:1751541,PMID:8993166 NOTES:NCD
reactant: MODEL1310110061#

metaM galside hs e
constant: false
boundary condition: false
is: SBO:0000247
is: CHEBI:12947
notes: FORMULA: C24H46NO7FULLRCO CHARGE: 0 EHMN_ABBREVIATION: C02686
initial concentration: 1.0
type: Species
has only substance units: false
name: D-galactosyl-N-acylsphingosine
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110061#_cfd80ff1_92ad_44e2_b788_5cf7497427ce
initial amount: NaN
is encoded by: hsa:249
boundary condition: true
is: B7Z4Y6
has only substance units: false
type: Species
constant: false
is: SBO:0000252
name: ALPL
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110061#_7ed7284c_091d_47b2_b78c_470888928378
constant: false
type: Species
boundary condition: true
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:4258
is: SBO:0000252
has only substance units: false
name: MGST2
is: D6RBB5

metaR ICDHy
name: isocitrate dehydrogenase (NADP)
is described by: ECO:0000269
fast: false
type: Reaction
is version of: http://identifiers.org/ec-code/1.1.1.42
reversible: false
notes: GENE_ASSOCIATION: (3417.1) SUBSYSTEM: Citric acid cycle EC Number: 1.1.1.42 Confidence Level: 4 AUTHORS: PMID:10521434 NOTES:Two reactions (ICDH1 and ICDH2) for isocitrate dehydrogenase
kinetic law: MODEL1310110061#
is: SBO:0000176
reactant: MODEL1310110061#
modifier: MODEL1310110061#
product: MODEL1310110061#

metaR r1610
type: Reaction
kinetic law: MODEL1310110061#
reversible: true
reactant: MODEL1310110061#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is described by: ECO:0000000
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is: SBO:0000185
product: MODEL1310110061#

metaR DNDPt8m
modifier: MODEL1310110061#
type: Reaction
notes: GENE_ASSOCIATION: (60386.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:11226231 NOTES:IT
reactant: MODEL1310110061#
is: SBO:0000185
fast: false
kinetic law: MODEL1310110061#
is described by: ECO:0000269
name: dADP transport via dUDP antiport
reversible: false
product: MODEL1310110061#

metaR OCDCAtr
is: SBO:0000185
product: MODEL1310110061#
type: Reaction
reversible: true
kinetic law: MODEL1310110061#
name: fatty acid transport via diffusion
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11788354,PMID:12864740 NOTES:NJ
reactant: MODEL1310110061#
fast: false

metaM dcsptn1 c
has only substance units: false
boundary condition: false
name: docosa-4,7,10,13,16-pentaenoic acid
constant: false
is: http://identifiers.org/pubchem.compound/5282848
is: HMDB13123
is: SBO:0000247
initial amount: NaN
type: Species
initial concentration: 1.0
notes: FORMULA: C22H33O2 CHARGE: -1 INCHI: InChI=1/C22H34O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22(23)24/h6-7,9-10,12-13,15-16,18-19H,2-5,8,11,14,17,20-21H2,1H3,(H,23,24)/b7-6-,10-9-,13-12-,16-15-,19-18-

metaR FAOXTC122m
kinetic law: MODEL1310110061#
product: MODEL1310110061#
reactant: MODEL1310110061#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: isomerization trans(C12:2)m
type: Reaction

metaR r1374
is: SBO:0000176
type: Reaction
product: MODEL1310110061#
fast: false
is described by: ECO:0000000
reactant: MODEL1310110061#
name: EC:3.2.1.14
kinetic law: MODEL1310110061#
notes: GENE_ASSOCIATION: SUBSYSTEM: Aminosugar metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:17267599 NOTES:
reversible: false

metaR P4508B11r
product: MODEL1310110061#
name: sterol 12-alpha-hydroxylase
reactant: MODEL1310110061#
modifier: MODEL1310110061#
fast: false
is: SBO:0000176
reversible: false
kinetic law: MODEL1310110061#
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (1582.1) SUBSYSTEM: Bile acid synthesis EC Number: Confidence Level: 4 AUTHORS: NOTES:NJ - added, substrates by analogy to other xol hydroxylase reactions (NADH and NADPH can both be used)
type: Reaction
is version of: http://identifiers.org/ec-code/1.14.13.95

http://identifiers.org/biomodels.db/MODEL1310110061#_0fafd343_6dd1_419d_94b5_1d45d18dac97
type: Species
name: HAS1
has only substance units: false
constant: false
initial amount: NaN
is: SBO:0000252
initial concentration: NaN
is: Q8IYH3
is encoded by: hsa:3036
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110061#_ba85afa6_e841_4d3c_b196_e104cdd70942
name: PLCD4
is: SBO:0000252
is: Q9BRC7
initial amount: NaN
constant: false
initial concentration: NaN
boundary condition: true
is encoded by: hsa:84812
has only substance units: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110061#_74dc7f70_fc16_4740_923d_661b313a8459
is encoded by: hsa:170712
name: COX7B2
boundary condition: true
is: SBO:0000252
constant: false
is: Q8TF08
initial amount: NaN
type: Species
initial concentration: NaN
has only substance units: false

metaM udpacgal c
type: Species
constant: false
boundary condition: false
is: HMDB00304
is: CHEBI:57847
initial amount: NaN
has only substance units: false
initial concentration: 1.0
is: SBO:0000247
name: UDP-N-acetyl-D-galactosamine(2-)
notes: FORMULA: C17H25N3O17P2 CHARGE: -2 INCHI: InChI=1S/C17H27N3O17P2/c1-6(22)18-10-13(26)11(24)7(4-21)35-16(10)36-39(31,32)37-38(29,30)33-5-8-12(25)14(27)15(34-8)20-3-2-9(23)19-17(20)28/h2-3,7-8,10-16,21,24-27H,4-5H2,1H3,(H,18,22)(H,29,30)(H,31,32)(H,19,23,28)/p-2/t7-,8-,10-,11+,12-,13-,14-,15-,16?/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00190 EHMN_ABBREVIATION: C00203

metaM dhap m
is: SBO:0000247
initial amount: NaN
is: http://identifiers.org/pubchem.compound/3411
name: Dihydroxyacetone phosphate
initial concentration: 1.0
constant: false
type: Species
boundary condition: false
is: HMDB01473
has only substance units: false
is: C00111

http://identifiers.org/biomodels.db/MODEL1310110061#_8425d4ce_55b3_4b41_8467_e51d9bc36775
initial concentration: NaN
has only substance units: false
is encoded by: hsa:7264
name: TSTA3
is: Q13630
constant: false
boundary condition: true
initial amount: NaN
type: Species
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110061#_183552ae_f44e_4529_a959_1c165f3030c5
initial concentration: NaN
name: GALNT9
is: SBO:0000252
type: Species
initial amount: NaN
boundary condition: true
is: Q9HCQ5
has only substance units: false
constant: false
is encoded by: hsa:50614

metaR RETH
name: retinyl ester hydrolase
kinetic law: MODEL1310110061#
reversible: false
fast: false
product: MODEL1310110061#
is: SBO:0000176
reactant: MODEL1310110061#
type: Reaction
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/3.1.1.3
modifier: MODEL1310110061#
notes: GENE_ASSOCIATION: (8228.1) SUBSYSTEM: Vitamin A metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:1503811,PMID:15955102 NOTES:IT

metaR RE0344C
notes: GENE_ASSOCIATION: (641372.1) or (641371.1) or (570.1) SUBSYSTEM: Fatty acid synthesis EC Number: 3.1.2.2 Confidence Level: 0 AUTHORS: PMID:10092594,PMID:10578051,PMID:16103133,PMID:16940157,PMID:9153233 NOTES:
name: RE0344
reversible: true
reactant: MODEL1310110061#
is described by: ECO:0000000
product: MODEL1310110061#
modifier: MODEL1310110061#
type: Reaction
is version of: http://identifiers.org/ec-code/3.1.2.2
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.3.1.65
kinetic law: MODEL1310110061#
fast: false

http://identifiers.org/biomodels.db/MODEL1310110061#_01b8d35a_4ee4_4525_b4ac_c27517ac7126
boundary condition: true
constant: false
is encoded by: hsa:376497
initial concentration: NaN
initial amount: NaN
is: Q6PCB7
has only substance units: false
is: SBO:0000252
type: Species
name: SLC27A1

metaR r2405
product: MODEL1310110061#
fast: false
reversible: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172 NOTES:
type: Reaction
kinetic law: MODEL1310110061#
name: Mitochondrial Carrier (MC) TCDB:2.A.29.19.1
is: SBO:0000185
is described by: ECO:0000000
reactant: MODEL1310110061#

metaM 4pyrdx c
is: SBO:0000247
boundary condition: false
name: 4-pyridoxate
type: Species
is: CHEBI:30959
notes: FORMULA: C8H9NO4 CHARGE: 0 INCHI: InChI=1S/C8H9NO4/c1-4-7(11)6(8(12)13)5(3-10)2-9-4/h2,10-11H,3H2,1H3,(H,12,13)/p-1 EHMN_ABBREVIATION: C00847
is: HMDB00017
initial concentration: 1.0
has only substance units: false
initial amount: NaN
constant: false

http://identifiers.org/biomodels.db/MODEL1310110061#_d5aeeec9_f593_49ec_b4c8_417dcf6912ba
has only substance units: false
initial concentration: NaN
is: SBO:0000252
constant: false
initial amount: NaN
is encoded by: hsa:53
is: E9PCI1
type: Species
boundary condition: true
name: ACP2

http://identifiers.org/biomodels.db/MODEL1310110061#_520b2291_24bd_4841_89f3_d141b930d9a2
is encoded by: hsa:8803
initial concentration: NaN
initial amount: NaN
constant: false
boundary condition: true
type: Species
is: SBO:0000252
has only substance units: false
is: E5KS60
name: SUCLA2

metaR EX no LPAREN e RPAREN
kinetic law: MODEL1310110061#
reactant: MODEL1310110061#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for NO
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110061#_36ec3f42_fa42_46dd_9dd5_3505a88ae11c
constant: false
type: Species
is: SBO:0000252
boundary condition: true
has only substance units: false
is: P07954
initial concentration: NaN
name: FH
is encoded by: hsa:2271
initial amount: NaN

metaM 5mthf e
initial amount: NaN
is: C00440
has only substance units: false
name: 5-Methyltetrahydrofolate
is: HMDB01396
is: CHEBI:3729
boundary condition: false
initial concentration: 1.0
is: SBO:0000247
constant: false
notes: FORMULA: C20H24N7O6 CHARGE: -1
type: Species

metaR r0242
product: MODEL1310110061#
fast: false
reversible: true
notes: GENE_ASSOCIATION: (84532.1) or (55902.1) or (79611.1) SUBSYSTEM: Unassigned EC Number: 3.1.3.1 Confidence Level: 0 AUTHORS: PMID:1730777,PMID:3042787 NOTES:
is: SBO:0000176
type: Reaction
kinetic law: MODEL1310110061#
modifier: MODEL1310110061#
is version of: http://identifiers.org/ec-code/6.2.1.1
reactant: MODEL1310110061#
is described by: ECO:0000000
name: Glycerone phosphate phosphohydrolase (alkaline optimum) EC:3.1.3.1

metaM citr L m
has only substance units: false
type: Species
name: L-citrulline
boundary condition: false
constant: false
initial amount: NaN
is: CHEBI:16349
notes: FORMULA: C6H13N3O3 CHARGE: 0 INCHI: InChI=1S/C6H13N3O3/c7-4(5(10)11)2-1-3-9-6(8)12/h4H,1-3,7H2,(H,10,11)(H3,8,9,12)/t4-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00277
initial concentration: 1.0
is: HMDB00904
is: SBO:0000247

metaR r1375
fast: false
kinetic law: MODEL1310110061#
type: Reaction
is described by: ECO:0000000
is: SBO:0000185
reactant: MODEL1310110061#
product: MODEL1310110061#
notes: GENE_ASSOCIATION: SUBSYSTEM: Aminosugar metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:17267599 NOTES:
name: Transport reaction
reversible: false

metaR GLYt2r
reactant: MODEL1310110061#
modifier: MODEL1310110061#
kinetic law: MODEL1310110061#
product: MODEL1310110061#
notes: GENE_ASSOCIATION: (206358.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11390972,PMID:11959859 NOTES:NCD
reversible: true
name: glycine reversible transport via proton symport
type: Reaction
is described by: ECO:0000304
fast: false
is: SBO:0000185

metaR RE3218C
type: Reaction
is described by: ECO:0000000
is: SBO:0000176
notes: GENE_ASSOCIATION: (412.1) SUBSYSTEM: Androgen and estrogen synthesis and metabolism EC Number: 3.1.6.2 Confidence Level: 0 AUTHORS: PMID:11886493 NOTES:IT - fixed proton
fast: false
reversible: true
reactant: MODEL1310110061#
is version of: http://identifiers.org/ec-code/3.1.6.2
modifier: MODEL1310110061#
name: RE3218
kinetic law: MODEL1310110061#
product: MODEL1310110061#

metaR ASNtN1
product: MODEL1310110061#
kinetic law: MODEL1310110061#
reactant: MODEL1310110061#
modifier: MODEL1310110061#
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (92745.1) or (10991.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10823827,PMID:12845534 NOTES:SAB based om PMID 10823827
type: Reaction
name: Asparagine transport (Na, H coupled)
is: SBO:0000185
fast: false
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110061#_14ff5faf_dccd_470a_838f_4a1f05cf9f8b
initial amount: NaN
constant: false
boundary condition: true
is: SBO:0000252
is encoded by: hsa:64078
is: Q9HAS3
name: SLC28A3
has only substance units: false
initial concentration: NaN
type: Species

metaR SIAASE3ly
kinetic law: MODEL1310110061#
is: SBO:0000176
reversible: false
is version of: http://identifiers.org/ec-code/3.1.6.4
modifier: MODEL1310110061#
is version of: http://identifiers.org/ec-code/3.4.16.5
type: Reaction
is described by: ECO:0000000
name: sialidase, lysosomal
is version of: http://identifiers.org/ec-code/3.2.1.23
fast: false
reactant: MODEL1310110061#
product: MODEL1310110061#
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.18 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD
is version of: http://identifiers.org/ec-code/3.2.1.18

http://identifiers.org/biomodels.db/MODEL1310110061#_d98eb445_306a_4364_adb8_18568ea66d9f
is encoded by: hsa:AI440329
name: _AI440329_1_r
is: SBO:0000252
constant: false
initial amount: NaN
has only substance units: false
type: Species
boundary condition: true
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110061#_69fa5bf9_afa5_46e5_8d55_2d52421439a9
is: SBO:0000252
name: _AI222095_1_m
is encoded by: hsa:AI222095
constant: false
boundary condition: true
has only substance units: false
initial amount: NaN
initial concentration: NaN
type: Species

metaM cytd n
is: SBO:0000247
is: HMDB00089
boundary condition: false
name: cytidine
type: Species
initial amount: NaN
initial concentration: 1.0
is: CHEBI:17562
notes: FORMULA: C9H13N3O5 CHARGE: 0 INCHI: InChI=1S/C9H13N3O5/c10-5-1-2-12(9(16)11-5)8-7(15)6(14)4(3-13)17-8/h1-2,4,6-8,13-15H,3H2,(H2,10,11,16)/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00381 EHMN_ABBREVIATION: C00475
has only substance units: false
constant: false

metaM frdp c
is: HMDB00961
initial concentration: 1.0
initial amount: NaN
boundary condition: false
type: Species
constant: false
has only substance units: false
notes: FORMULA: C15H25O7P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00362 EHMN_ABBREVIATION: C00448
is: CHEBI:175763
is: C00448
name: Farnesyl diphosphate
is: SBO:0000247

metaR ADRNCOAtx
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: NOTES:interaction between peroxisomes and ER (some enzymes on the outer membrane) NJ
fast: false
name: fatty acid intracellular transport
is described by: ECO:0000000
product: MODEL1310110061#
is: SBO:0000185
reversible: true
type: Reaction
reactant: MODEL1310110061#
kinetic law: MODEL1310110061#

metaR r1934
type: Reaction
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reversible: false
name: Y+LAT2 Utilized transport
kinetic law: MODEL1310110061#
is: SBO:0000185
modifier: MODEL1310110061#
reactant: MODEL1310110061#
fast: false
product: MODEL1310110061#

metaM tdchola c
initial concentration: 1.0
notes: FORMULA: C26H45NO6S CHARGE: 0 INCHI: InChI=1S/C26H45NO6S/c1-16(4-7-23(30)27-12-13-34(31,32)33)19-5-6-20-24-21(9-11-26(19,20)3)25(2)10-8-18(28)14-17(25)15-22(24)29/h16-22,24,28-29H,4-15H2,1-3H3,(H,27,30)(H,31,32,33)/p-1/t16-,17+,18-,19-,20+,21+,22-,24+,25+,26-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01471 EHMN_ABBREVIATION: C05465
has only substance units: false
is: SBO:0000247
initial amount: NaN
constant: false
name: taurochenodeoxycholate
is: CHEBI:9407
is: HMDB00951
type: Species
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110061#_14a37ae6_adae_46a8_bbd4_78eb809daa75
boundary condition: true
type: Species
has only substance units: false
constant: false
name: PIP4K2B
is: SBO:0000252
initial concentration: NaN
is: P78356
initial amount: NaN
is encoded by: hsa:8396

metaM ctp e
is: HMDB00082
is: SBO:0000247
initial amount: NaN
initial concentration: 1.0
is: CHEBI:37563
name: CTP(4-)
type: Species
notes: FORMULA: C9H12N3O14P3 CHARGE: -4 INCHI: InChI=1S/C9H16N3O14P3/c10-5-1-2-12(9(15)11-5)8-7(14)6(13)4(24-8)3-23-28(19,20)26-29(21,22)25-27(16,17)18/h1-2,4,6-8,13-14H,3H2,(H,19,20)(H,21,22)(H2,10,11,15)(H2,16,17,18)/p-4/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00066 EHMN_ABBREVIATION: C00063
boundary condition: false
has only substance units: false
constant: false

metaM dcsptn1 e
notes: FORMULA: C22H33O2 CHARGE: -1 INCHI: InChI=1/C22H34O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22(23)24/h6-7,9-10,12-13,15-16,18-19H,2-5,8,11,14,17,20-21H2,1H3,(H,23,24)/b7-6-,10-9-,13-12-,16-15-,19-18-
boundary condition: false
is: SBO:0000247
initial concentration: 1.0
name: docosa-4,7,10,13,16-pentaenoic acid
is: HMDB13123
is: http://identifiers.org/pubchem.compound/5282848
initial amount: NaN
constant: false
has only substance units: false
type: Species

metaR EX glc LPAREN e RPAREN
kinetic law: MODEL1310110061#
reactant: MODEL1310110061#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: D-Glucose exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110061#_19421472_0883_4450_98ae_df3b4123f77a
has only substance units: false
initial concentration: NaN
is: SBO:0000252
boundary condition: true
is encoded by: hsa:3631
initial amount: NaN
name: INPP4A
is: Q96PE3
constant: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110061#_3b077e8f_0945_4467_886a_fe1c35c63add
name: ST20
is: SBO:0000252
is: Q9HBF5
initial amount: NaN
is encoded by: hsa:400410
has only substance units: false
boundary condition: true
type: Species
constant: false
initial concentration: NaN

metaR r2408
kinetic law: MODEL1310110061#
reactant: MODEL1310110061#
is described by: ECO:0000000
product: MODEL1310110061#
notes: GENE_ASSOCIATION: (8402.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172 NOTES:
is: SBO:0000185
fast: false
type: Reaction
reversible: false
modifier: MODEL1310110061#
name: Mitochondrial Carrier (MC) TCDB:2.A.29.19.1

metaR TYRDOPO3
is version of: http://identifiers.org/ec-code/1.14.18.1
reactant: MODEL1310110061#
fast: false
is described by: ECO:0000269
type: Reaction
is: SBO:0000176
notes: GENE_ASSOCIATION: (7299.1) SUBSYSTEM: Tyrosine metabolism EC Number: 1.14.18.1 Confidence Level: 4 AUTHORS: PMID:5294951 NOTES:SAB
product: MODEL1310110061#
kinetic law: MODEL1310110061#
name: Tyrosine:dopa oxidase (dopaquinone producing 2)
modifier: MODEL1310110061#
reversible: false

metaR GLCt4
is described by: ECO:0000269
kinetic law: MODEL1310110061#
product: MODEL1310110061#
reversible: true
fast: false
type: Reaction
notes: GENE_ASSOCIATION: (200010.1) or (159963.1) or (6526.1) or (125206.1) or (6524.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:11133510,PMID:12436245,PMID:12748858,PMID:1372904,PMID:1415574,PMID:15546855,PMID:7537337,PMID:7789985,PMID:8282810 NOTES:NCD
modifier: MODEL1310110061#
name: glucose transport via sodium symport
is: SBO:0000185
reactant: MODEL1310110061#

metaR 10FTHFtm
name: 10-Formyltetrahydrofolate mitochondrial transport via diffusion
is described by: ECO:0000000
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: PMID:11375437 NOTES:NCD
type: Reaction
fast: false
kinetic law: MODEL1310110061#
reactant: MODEL1310110061#
reversible: true
product: MODEL1310110061#

metaM atp n
constant: false
initial amount: NaN
type: Species
initial concentration: 1.0
is: HMDB00538
is: SBO:0000247
has only substance units: false
is: CHEBI:57299
name: ATP(3-)
boundary condition: false
notes: FORMULA: C10H12N5O13P3 CHARGE: -4 INCHI: InChI=1S/C10H16N5O13P3/c11-8-5-9(13-2-12-8)15(3-14-5)10-7(17)6(16)4(26-10)1-25-30(21,22)28-31(23,24)27-29(18,19)20/h2-4,6-7,10,16-17H,1H2,(H,21,22)(H,23,24)(H2,11,12,13)(H2,18,19,20)/p-3/t4-,6-,7-,10-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00012 EHMN_ABBREVIATION: C00002

metaR CYTK1n
kinetic law: MODEL1310110061#
is version of: http://identifiers.org/ec-code/2.7.4.14
modifier: MODEL1310110061#
name: cytidylate kinase (CMP),nuclear
product: MODEL1310110061#
is described by: ECO:0000269
reactant: MODEL1310110061#
type: Reaction
fast: false
is: SBO:0000176
reversible: true
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:

metaR DHCRD2
reactant: MODEL1310110061#
fast: false
product: MODEL1310110061#
reversible: false
is described by: ECO:0000269
kinetic law: MODEL1310110061#
type: Reaction
modifier: MODEL1310110061#
notes: GENE_ASSOCIATION: (8560.1) or (8560.2) SUBSYSTEM: Sphingolipid metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:9188692 NOTES:NJ
name: dihydroceramide desaturase
is: SBO:0000176

metaR DESAT18 6
is: SBO:0000176
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (9415.1) SUBSYSTEM: Fatty acid synthesis EC Number: 1.14.99.25 Confidence Level: 4 AUTHORS: NOTES:for homo sapiens, noted to actually be NADH-cyt b5, using NADH at present NJ
name: fatty acyl-CoA desaturase (n-C18:1CoA -> n-C18:2CoA)
fast: false
reactant: MODEL1310110061#
kinetic law: MODEL1310110061#
product: MODEL1310110061#
reversible: false
modifier: MODEL1310110061#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110061#_56dfb034_adf7_4182_9666_3f9df5445291
initial amount: NaN
boundary condition: true
initial concentration: NaN
has only substance units: false
constant: false
is: SBO:0000252
type: Species
is encoded by: hsa:23007
name: PLCH1
is: Q4KWH8

metaR PTPATe
kinetic law: MODEL1310110061#
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
reversible: true
type: Reaction
reactant: MODEL1310110061#
product: MODEL1310110061#
name: PTPATe
fast: false

http://identifiers.org/biomodels.db/MODEL1310110061#_725aa37c_d4ef_41c0_b2ed_24c54c1bbe3b
type: Species
is: O43865
boundary condition: true
is encoded by: hsa:10768
initial amount: NaN
has only substance units: false
name: AHCYL1
is: SBO:0000252
initial concentration: NaN
constant: false

metaR EX hexc LPAREN e RPAREN
kinetic law: MODEL1310110061#
reactant: MODEL1310110061#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: hexacosanoate (n-C26:0) exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110061#_af3f4a4d_102d_46dd_97fb_321d7f30b8c2
type: Species
is: SBO:0000252
name: COX7A2
is: H0UI06
initial concentration: NaN
has only substance units: false
initial amount: NaN
constant: false
boundary condition: true
is encoded by: hsa:1347

http://identifiers.org/biomodels.db/MODEL1310110061#_e96033b5_6dab_4f35_b9d1_fcc53c56920a
is encoded by: hsa:3422
is: SBO:0000252
boundary condition: true
initial concentration: NaN
name: IDI1
type: Species
initial amount: NaN
has only substance units: false
constant: false
is: Q13907

http://identifiers.org/biomodels.db/MODEL1310110061#_73ae6b98_8bea_477a_8aba_915efc53f776
is encoded by: hsa:160728
initial amount: NaN
is: Q8N695
boundary condition: true
is: SBO:0000252
constant: false
initial concentration: NaN
has only substance units: false
name: SLC5A8
type: Species

metaM dhcholestanate c
name: 3alpha,7alpha-Dihydroxy-5beta-cholestanate
initial concentration: 1.0
boundary condition: false
has only substance units: false
is: CHEBI:16577
is: SBO:0000247
is: HMDB00359
type: Species
constant: false
initial amount: NaN
notes: FORMULA: C27H45O4 CHARGE: -1 INCHI: InChI=1S/C27H46O4/c1-16(6-5-7-17(2)25(30)31)20-8-9-21-24-22(11-13-27(20,21)4)26(3)12-10-19(28)14-18(26)15-23(24)29/h16-24,28-29H,5-15H2,1-4H3,(H,30,31)/t16-,17?,18+,19-,20-,21+,22+,23-,24+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01313 EHMN_ABBREVIATION: C04554

http://identifiers.org/biomodels.db/MODEL1310110061#_45cda329_9368_4a8b_8a18_a1ea1573e1d0
initial concentration: NaN
name: PECR
constant: false
type: Species
is encoded by: hsa:55825
boundary condition: true
has only substance units: false
is: SBO:0000252
is: Q9BY49
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110061#_9a9e028c_d341_49e6_82b3_ca134342488f
constant: false
is encoded by: hsa:30814
initial amount: NaN
initial concentration: NaN
is: SBO:0000252
has only substance units: false
name: PLA2G2E
boundary condition: true
is: Q9NZK7
type: Species

metaM adp c
type: Species
is: HMDB01341
name: ADP
is: C00008
initial amount: NaN
constant: false
is: SBO:0000247
has only substance units: false
initial concentration: 1.0
boundary condition: false
is: CHEBI:16761
is: http://identifiers.org/pubchem.compound/3310

metaM 4pyrdx e
is: SBO:0000247
is: CHEBI:30959
is: HMDB00017
boundary condition: false
name: 4-pyridoxate
initial amount: NaN
notes: FORMULA: C8H9NO4 CHARGE: 0 INCHI: InChI=1S/C8H9NO4/c1-4-7(11)6(8(12)13)5(3-10)2-9-4/h2,10-11H,3H2,1H3,(H,12,13)/p-1 EHMN_ABBREVIATION: C00847
constant: false
has only substance units: false
initial concentration: 1.0
type: Species

metaR r2407
name: Mitochondrial Carrier (MC) TCDB:2.A.29.19.1
reversible: false
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172 NOTES:
product: MODEL1310110061#
type: Reaction
is: SBO:0000185
kinetic law: MODEL1310110061#
reactant: MODEL1310110061#
is described by: ECO:0000000

metaM atp m
initial concentration: 1.0
constant: false
initial amount: NaN
is: CHEBI:57299
boundary condition: false
type: Species
is: HMDB00538
is: SBO:0000247
name: ATP(4-)
has only substance units: false
is: C00002

metaR EX HC02207 LPAREN e RPAREN
kinetic law: MODEL1310110061#
reactant: MODEL1310110061#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: prostaglandin-c2 exchange
type: Reaction

metaM pan4p c
is: SBO:0000247
is: C01134
has only substance units: false
notes: FORMULA: C11H21N2O7PS CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00681 EHMN_ABBREVIATION: C01134
type: Species
initial amount: NaN
name: Pantetheine 4'-phosphate
constant: false
is: CHEBI:47942
boundary condition: false
is: HMDB01416
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110061#_dafa9108_dcfd_4c8a_adce_b14e83bae46d
boundary condition: true
name: OXSM
is: Q9NWU1
initial concentration: NaN
initial amount: NaN
has only substance units: false
constant: false
type: Species
is encoded by: hsa:54995
is: SBO:0000252

metaM fum c
initial concentration: 1.0
initial amount: NaN
has only substance units: false
is: C00122
name: Fumarate
constant: false
boundary condition: false
is: SBO:0000247
is: HMDB00134
is: CHEBI:29806
type: Species
notes: FORMULA: C4H2O4 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00120 EHMN_ABBREVIATION: C00122

metaR THYMt
is described by: ECO:0000269
name: thymine reversible transport via facilated diffusion
is: SBO:0000185
type: Reaction
product: MODEL1310110061#
reactant: MODEL1310110061#
modifier: MODEL1310110061#
reversible: true
notes: GENE_ASSOCIATION: (3177.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12006583,PMID:12838422 NOTES:IT
fast: false
kinetic law: MODEL1310110061#

metaM retinol 9 cis c
notes: FORMULA: C20H30O CHARGE: 0 INCHI: InChI=1S/C20H30O/c1-16(8-6-9-17(2)13-15-21)11-12-19-18(3)10-7-14-20(19,4)5/h6,8-9,11-13,21H,7,10,14-15H2,1-5H3/b9-6+,12-11+,16-8+,17-13+
constant: false
is: HMDB06217
type: Species
initial amount: NaN
has only substance units: false
name: 9-cis-retinol
initial concentration: 1.0
is: SBO:0000247
boundary condition: false
is: CHEBI:17336

metaM dhf c
is: HMDB01056
type: Species
has only substance units: false
initial concentration: 1.0
notes: FORMULA: C19H19N7O6 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00340 EHMN_ABBREVIATION: C00415
initial amount: NaN
boundary condition: false
constant: false
is: SBO:0000247
is: C00415
is: CHEBI:57451
name: 7,8-Dihydrofolate

http://identifiers.org/biomodels.db/MODEL1310110061#_60b98bc9_6582_4784_82c0_ebe872b03ca2
has only substance units: false
boundary condition: true
initial amount: NaN
is encoded by: hsa:131
name: ADH7
initial concentration: NaN
constant: false
is: SBO:0000252
is: P40394
type: Species

metaR XANtx
kinetic law: MODEL1310110061#
fast: false
reactant: MODEL1310110061#
is described by: ECO:0000000
reversible: false
name: xanthine diffusion in peroxisome
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: NOTES:IT
type: Reaction
product: MODEL1310110061#
is: SBO:0000185

metaR BTND1
product: MODEL1310110061#
is described by: ECO:0000269
kinetic law: MODEL1310110061#
type: Reaction
notes: GENE_ASSOCIATION: (686.1) SUBSYSTEM: Biotin metabolism EC Number: 3.5.1.12 Confidence Level: 4 AUTHORS: PMID:12459313,PMID:15059618 NOTES:IT
reversible: false
name: biotinidase (biotin)
reactant: MODEL1310110061#
modifier: MODEL1310110061#
is version of: http://identifiers.org/ec-code/3.5.1.12
is: SBO:0000176
fast: false

metaR r0245
fast: false
is: SBO:0000176
type: Reaction
kinetic law: MODEL1310110061#
notes: GENE_ASSOCIATION: (1719.1) or (HG2846-HT2983.1) SUBSYSTEM: Glycerophospholipid metabolism EC Number: 1.1.1.72 Confidence Level: 0 AUTHORS: PMID:11716357,PMID:6753936,PMID:6815419,PMID:8916913,PMID:9693960 NOTES:
modifier: MODEL1310110061#
reactant: MODEL1310110061#
product: MODEL1310110061#
is described by: ECO:0000000
name: Glycerol:NADP+ oxidoreductase Glycerolipid metabolism EC:1.1.1.2 EC:1.1.1.72
reversible: true
is version of: http://identifiers.org/ec-code/1.5.1.3

metaR PRISTCOAtcx
kinetic law: MODEL1310110061#
product: MODEL1310110061#
reactant: MODEL1310110061#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of pristanoylcoa from cytosol to peroxisomes.
type: Reaction

metaM HC00319 c
initial concentration: 1.0
notes: FORMULA: C3H2O4 CHARGE: -2 INCHI: InChI=1S/C3H4O4/c4-2(5)1-3(6)7/h1H2,(H,4,5)(H,6,7)
boundary condition: false
is: SBO:0000247
type: Species
constant: false
initial amount: NaN
has only substance units: false
is: CHEBI:30794
name: Malonate

http://identifiers.org/biomodels.db/MODEL1310110061#_11eff6e7_e980_4611_9c21_4b0470f37c50
has only substance units: false
type: Species
is encoded by: hsa:AI191472
constant: false
is: SBO:0000252
name: _AI191472_1_c
boundary condition: true
initial amount: NaN
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110061#_28c7975f_675f_4882_81d2_b2cd7dbc6e7b
boundary condition: true
constant: false
is: Q6FG42
type: Species
initial concentration: NaN
initial amount: NaN
name: NDUFA7
is encoded by: hsa:4701
is: SBO:0000252
has only substance units: false

metaR HIBDm
notes: GENE_ASSOCIATION: (11112.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 1.1.1.31 Confidence Level: 4 AUTHORS: PMID:7527207 NOTES:MM
modifier: MODEL1310110061#
type: Reaction
is: SBO:0000176
name: 3-hydroxyisobutyrate dehydrogenase, mitochondrial
reversible: true
product: MODEL1310110061#
is version of: http://identifiers.org/ec-code/1.1.1.31
reactant: MODEL1310110061#
is described by: ECO:0000269
kinetic law: MODEL1310110061#
fast: false

http://identifiers.org/biomodels.db/MODEL1310110061#_a9d119e9_e64f_492c_9f3f_e564d860dc26
is encoded by: hsa:760
constant: false
has only substance units: false
is: P00918
name: CA2
initial concentration: NaN
boundary condition: true
is: SBO:0000252
type: Species
initial amount: NaN

metaR DESAT18 4
name: stearoyl-CoA desaturase (n-C18:0CoA -> n-C18:1CoA)
is: SBO:0000176
product: MODEL1310110061#
reversible: false
kinetic law: MODEL1310110061#
fast: false
notes: GENE_ASSOCIATION: (6319.1) SUBSYSTEM: Fatty acid synthesis EC Number: 1.14.19.1 Confidence Level: 4 AUTHORS: PMID:14967823 NOTES:for homo sapiens, noted to actually be NADH-cyt b5, using NADH at present NJ
reactant: MODEL1310110061#
modifier: MODEL1310110061#
is version of: http://identifiers.org/ec-code/1.14.19.1
is described by: ECO:0000000
type: Reaction

metaR r1931
reversible: false
is described by: ECO:0000000
type: Reaction
modifier: MODEL1310110061#
fast: false
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
name: Y+LAT2 Utilized transport
kinetic law: MODEL1310110061#
is: SBO:0000185
product: MODEL1310110061#
reactant: MODEL1310110061#

metaM cmp g
initial amount: NaN
notes: FORMULA: C9H12N3O8P CHARGE: -2 INCHI: InChI=1S/C9H14N3O8P/c10-5-1-2-12(9(15)11-5)8-7(14)6(13)4(20-8)3-19-21(16,17)18/h1-2,4,6-8,13-14H,3H2,(H2,10,11,15)(H2,16,17,18)/p-2/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00060 EHMN_ABBREVIATION: C00055
is: CHEBI:60377
boundary condition: false
is: SBO:0000247
name: CMP(2-)
constant: false
has only substance units: false
is: HMDB00095
initial concentration: 1.0
type: Species

metaM ksii core2 deg6 l
has only substance units: false
initial amount: NaN
boundary condition: false
is: HMDB00143
is: SBO:0000247
type: Species
constant: false
notes: FORMULA: C44H72N4O33SX CHARGE: -1
is: CHEBI:12936
initial concentration: 1.0
name: keratan sulfate II (core 2-linked), degradation product 6

metaM udpacgal g
has only substance units: false
boundary condition: false
type: Species
constant: false
is: HMDB00304
is: CHEBI:57847
notes: FORMULA: C17H25N3O17P2 CHARGE: -2 INCHI: InChI=1S/C17H27N3O17P2/c1-6(22)18-10-13(26)11(24)7(4-21)35-16(10)36-39(31,32)37-38(29,30)33-5-8-12(25)14(27)15(34-8)20-3-2-9(23)19-17(20)28/h2-3,7-8,10-16,21,24-27H,4-5H2,1H3,(H,18,22)(H,29,30)(H,31,32)(H,19,23,28)/p-2/t7-,8-,10-,11+,12-,13-,14-,15-,16?/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00190 EHMN_ABBREVIATION: C00203
initial amount: NaN
name: UDP-N-acetyl-D-galactosamine(2-)
initial concentration: 1.0
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110061#_6981efcf_1394_4c64_9cf2_7f55ed58b6b8
type: Species
boundary condition: true
initial concentration: NaN
has only substance units: false
constant: false
is: SBO:0000252
is encoded by: hsa:3613
initial amount: NaN
is: O14732
name: IMPA2

metaM 3octdectecoa m
boundary condition: false
notes: FORMULA: C39H58N7O17P3S CHARGE: -4
is: SBO:0000247
type: Species
has only substance units: false
is: HMDB02288
name: 3,6,9,12-octadecatetraenoylcoa
initial concentration: 1.0
initial amount: NaN
constant: false

metaR r0246
name: Glycerol:NADP+ oxidoreductase Glycerolipid metabolism EC:1.1.1.72 EC:1.1.1.2
is version of: http://identifiers.org/ec-code/1.5.1.3
notes: GENE_ASSOCIATION: (1719.1) or (HG2846-HT2983.1) SUBSYSTEM: Unassigned EC Number: 1.1.1.72 Confidence Level: 0 AUTHORS: PMID:11716357,PMID:6753936,PMID:6815419,PMID:8916913,PMID:9693960 NOTES:
modifier: MODEL1310110061#
is: SBO:0000176
type: Reaction
reactant: MODEL1310110061#
reversible: false
fast: false
is described by: ECO:0000000
kinetic law: MODEL1310110061#
product: MODEL1310110061#

metaM HC01409 m
boundary condition: false
is: SBO:0000247
has only substance units: false
initial amount: NaN
initial concentration: 1.0
name: Hexanoyl-CoA
notes: FORMULA: C27H42N7O17P3S CHARGE: -4 INCHI: InChI=1S/C27H46N7O17P3S/c1-4-5-6-7-18(36)55-11-10-29-17(35)8-9-30-25(39)22(38)27(2,3)13-48-54(45,46)51-53(43,44)47-12-16-21(50-52(40,41)42)20(37)26(49-16)34-15-33-19-23(28)31-14-32-24(19)34/h14-16,20-22,26,37-38H,4-13H2,1-3H3,(H,29,35)(H,30,39)(H,43,44)(H,45,46)(H2,28,31,32)(H2,40,41,42)/t16-,20-,21-,22+,26-/m1/s1 EHMN_ABBREVIATION: C05270
constant: false
type: Species
is: CHEBI:27540

metaR CYTK11n
reactant: MODEL1310110061#
name: cytidylate kinase (dCMP,dGTP),nuclear
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
is version of: http://identifiers.org/ec-code/2.7.4.14
reversible: true
type: Reaction
fast: false
is described by: ECO:0000269
kinetic law: MODEL1310110061#
product: MODEL1310110061#
modifier: MODEL1310110061#
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110061#_f3d5c2f2_8e62_4e6c_82f2_1191fb143a26
type: Species
is: SBO:0000252
name: ETFA
is: P13804
constant: false
initial concentration: NaN
initial amount: NaN
boundary condition: true
is encoded by: hsa:2108
has only substance units: false

metaR DM 4abut LPAREN n RPAREN
kinetic law: MODEL1310110061#
reactant: MODEL1310110061#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: PMID: 16643338 NOTES:GABA in the intestine may aid in differentiation and proliferation of epithelial cells. GABA intake by oral administration has been shown to alleviate stress, worry and anxiety and additionally it can also improve human immunity (PMID: 16971751). However the PAT1 transporter located at the apical side of enterocytes have very low affinity for GABA. I have presumed that this oral GABA is used within intestine (unless administered at high very high pharmacological doses, GABA exit from the enterocytes may be mediated by other specifc transporters).
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: Demand for 4-Aminobutanoate(n)
type: Reaction

metaM ctp c
is: CHEBI:37563
name: CTP
constant: false
initial amount: NaN
is: SBO:0000247
boundary condition: false
is: C00063
initial concentration: 1.0
type: Species
notes: FORMULA: C9H12N3O14P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00066 EHMN_ABBREVIATION: C00063
has only substance units: false
is: HMDB00082

http://identifiers.org/biomodels.db/MODEL1310110061#_7d5adf9f_fffc_4933_a7e6_a4f613198053
is encoded by: hsa:4758
is: SBO:0000252
has only substance units: false
initial amount: NaN
is: Q99519
constant: false
type: Species
initial concentration: NaN
boundary condition: true
name: NEU1

metaR ASCBt
is described by: ECO:0000000
is: SBO:0000185
type: Reaction
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:15705056,PMID:3715892 NOTES:NCD
product: MODEL1310110061#
name: L-ascorbate transport via facilitated diffusion
kinetic law: MODEL1310110061#
reactant: MODEL1310110061#
reversible: true

metaR CYTK9n
is described by: ECO:0000269
type: Reaction
kinetic law: MODEL1310110061#
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
is: SBO:0000176
reversible: true
name: cytidylate kinase (CMP,dCTP),nuclear
product: MODEL1310110061#
is version of: http://identifiers.org/ec-code/2.7.4.14
reactant: MODEL1310110061#
fast: false
modifier: MODEL1310110061#

metaR r1930
kinetic law: MODEL1310110061#
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is: SBO:0000185
modifier: MODEL1310110061#
type: Reaction
product: MODEL1310110061#
is described by: ECO:0000000
fast: false
name: Y+LAT2 Utilized transport
reversible: false
reactant: MODEL1310110061#

metaR r2064
is described by: ECO:0000000
type: Reaction
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.15
reversible: false
kinetic law: MODEL1310110061#
is: SBO:0000185
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
modifier: MODEL1310110061#
reactant: MODEL1310110061#
fast: false
product: MODEL1310110061#

metaM xylt e
has only substance units: false
is: CHEBI:17151
initial amount: NaN
boundary condition: false
constant: false
is: HMDB02917
is: SBO:0000247
type: Species
notes: FORMULA: C5H12O5 CHARGE: 0 INCHI: InChI=1S/C5H12O5/c6-1-3(8)5(10)4(9)2-7/h3-10H,1-2H2/t3-,4+,5+ HEPATONET_1.0_ABBREVIATION: HC00317 EHMN_ABBREVIATION: C00379
name: xylitol
initial concentration: 1.0

metaM hexe3coa m
is: HMDB06522
initial amount: NaN
is: SBO:0000247
notes: FORMULA: C27H40N7O17P3S CHARGE: -4
boundary condition: false
initial concentration: 1.0
type: Species
name: 3-hexenoylcoa
constant: false
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110061#_61f8537c_f7e6_4738_b8a9_099eea477d02
name: ACAA1
type: Species
boundary condition: true
initial concentration: NaN
is: Q96CA6
initial amount: NaN
constant: false
is: SBO:0000252
is encoded by: hsa:30
has only substance units: false

metaR NDP8
is described by: ECO:0000269
is: SBO:0000176
fast: false
modifier: MODEL1310110061#
product: MODEL1310110061#
is version of: http://identifiers.org/ec-code/2.7.4.9
reactant: MODEL1310110061#
reversible: false
notes: GENE_ASSOCIATION: (1841.1) SUBSYSTEM: Nucleotide interconversion EC Number: 3.6.1.6 Confidence Level: 4 AUTHORS: NOTES:
type: Reaction
name: nucleoside-diphosphatase (dUDP)
kinetic law: MODEL1310110061#

metaR r0629
is described by: ECO:0000000
modifier: MODEL1310110061#
product: MODEL1310110061#
is version of: http://identifiers.org/ec-code/3.1.4.1
reactant: MODEL1310110061#
type: Reaction
is: SBO:0000176
reversible: true
fast: false
kinetic law: MODEL1310110061#
name: Choloyl-CoA:glycine N-choloyltransferase Bile acid biosynthesis / Taurine and hypotaurine metabolism EC:2.3.1.65
is version of: http://identifiers.org/ec-code/3.6.1.22
notes: GENE_ASSOCIATION: (AI926493.1) or (5167.1) or (5169.1) or (83594.1) SUBSYSTEM: Bile acid synthesis EC Number: 2.3.1.65 Confidence Level: 0 AUTHORS: PMID:10884298,PMID:12239217,PMID:12543708,PMID:15026425,PMID:3741411,PMID:6884990 NOTES:

metaR FAOXC102m
kinetic law: MODEL1310110061#
product: MODEL1310110061#
reactant: MODEL1310110061#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: isomerization(C10:2)m
type: Reaction

metaM pser L c
is: SBO:0000247
has only substance units: false
boundary condition: false
notes: FORMULA: C3H5NO6P CHARGE: -3 INCHI: InChI=1S/C3H8NO6P/c4-2(3(5)6)1-10-11(7,8)9/h2H,1,4H2,(H,5,6)(H2,7,8,9)/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00621
is: CHEBI:15811
type: Species
constant: false
is: HMDB01721
initial concentration: 1.0
name: O-Phospho-L-serine
initial amount: NaN

metaM 3snpyr m
has only substance units: false
initial amount: NaN
initial concentration: 1.0
type: Species
notes: FORMULA: C3H2O5S CHARGE: -2 INCHI: InChI=1S/C3H4O5S/c4-2(3(5)6)1-9(7)8/h1H2,(H,5,6)(H,7,8) EHMN_ABBREVIATION: C05527
boundary condition: false
name: 3-Sulfinopyruvate
is: SBO:0000247
constant: false
is: HMDB02332
is: CHEBI:1665

metaM thymd c
name: Thymidine
is: C00214
constant: false
type: Species
has only substance units: false
initial concentration: 1.0
is: SBO:0000247
initial amount: NaN
is: HMDB00273
boundary condition: false
is: CHEBI:17748
notes: FORMULA: C10H14N2O5 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00198 EHMN_ABBREVIATION: C00214

metaR UGALNACtg
product: MODEL1310110061#
notes: GENE_ASSOCIATION: (7355.1) SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 4 AUTHORS: PMID:11784306,PMID:8889805,PMID:9010752,PMID:9399569,PMID:9562625 NOTES:NCD
kinetic law: MODEL1310110061#
is described by: ECO:0000269
reactant: MODEL1310110061#
type: Reaction
name: UDP-GalNAc Golgi transport via CMP antiport
is: SBO:0000185
reversible: true
modifier: MODEL1310110061#
fast: false

metaR r2520
type: Reaction
reversible: true
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:15845418 NOTES:
product: MODEL1310110061#
reactant: MODEL1310110061#
is described by: ECO:0000000
fast: false
kinetic law: MODEL1310110061#
name: Mitochondrial Carrier (MC) TCDB:2.A.29.2.1

metaM fpram c
boundary condition: false
initial concentration: 1.0
is: CHEBI:58478
name: 2-(Formamido)-N1-(5-phospho-D-ribosyl)acetamidine
has only substance units: false
is: HMDB06211
constant: false
is: SBO:0000247
type: Species
is: C04640
notes: FORMULA: C8H15N3O8P CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC01329 EHMN_ABBREVIATION: C04640
initial amount: NaN

metaR FAS120COA
type: Reaction
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (2194.1) SUBSYSTEM: Fatty acid synthesis EC Number: 2.3.1.86 Confidence Level: 4 AUTHORS: PMID:11756679,PMID:15507492 NOTES:NCD
name: fatty-acyl-CoA synthase (n-C12:0CoA)
kinetic law: MODEL1310110061#
product: MODEL1310110061#
modifier: MODEL1310110061#
fast: false
is version of: http://identifiers.org/ec-code/2.3.1.85
is: SBO:0000176
reactant: MODEL1310110061#
reversible: false

metaR r1619
modifier: MODEL1310110061#
reversible: true
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
kinetic law: MODEL1310110061#
type: Reaction
notes: GENE_ASSOCIATION: (19.1) or (AL038231.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is: SBO:0000185
reactant: MODEL1310110061#
is described by: ECO:0000000
fast: false
product: MODEL1310110061#

metaM g6p c
is: CHEBI:61548
has only substance units: false
initial amount: NaN
initial concentration: 1.0
notes: FORMULA: C6H11O9P CHARGE: -2 INCHI: "1/C5H11/c1-3-5-4-2/h1,3-5H2,2H3 HEPATONET_1.0_ABBREVIATION: HC00094 EHMN_ABBREVIATION: C00092
name: D-Glucose 6-phosphate
is: C00092
is: SBO:0000247
is: HMDB01401
constant: false
boundary condition: false
type: Species

metaR GLYt7 211 r
fast: false
product: MODEL1310110061#
kinetic law: MODEL1310110061#
reactant: MODEL1310110061#
reversible: true
notes: GENE_ASSOCIATION: (6536.1) or (6536.2) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12719981 NOTES:SAB
type: Reaction
name: glycine reversible transport via sodium and chloride symport (2:1:1)
modifier: MODEL1310110061#
is described by: ECO:0000269
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110061#_6e5db74e_f215_4c04_8033_9e826b6fe483
initial amount: NaN
is: SBO:0000252
has only substance units: false
constant: false
is encoded by: hsa:765
name: CA6
initial concentration: NaN
type: Species
is: Q5FC00
boundary condition: true

metaM adrncoa x
notes: FORMULA: C43H66N7O17P3S CHARGE: -4 INCHI: InChI=1/C43H70N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-34(52)71-27-26-45-33(51)24-25-46-41(55)38(54)43(2,3)29-64-70(61,62)67-69(59,60)63-28-32-37(66-68(56,57)58)36(53)42(65-32)50-31-49-35-39(44)47-30-48-40(35)50/h8-9,11-12,14-15,17-18,30-32,36-38,42,53-54H,4-7,10,13,16,19-29H2,1-3H3,(H,45,51)(H,46,55)(H,59,60)(H,61,62)(H2,44,47,48)(H2,56,57,58)/b9-8-,12-11-,15-14-,18-17-/t32-,36-,37-,38?,42-/m1/s1
has only substance units: false
is: SBO:0000247
name: adrenyl coenzyme A
initial concentration: 1.0
type: Species
constant: false
is: http://identifiers.org/pubchem.compound/47205480
initial amount: NaN
boundary condition: false
is: C16170

metaR LNLNCAt
name: fatty acid transport via diffusion
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11788354,PMID:12864740 NOTES:NJ
kinetic law: MODEL1310110061#
is: SBO:0000185
reversible: true
reactant: MODEL1310110061#
fast: false
is described by: ECO:0000000
product: MODEL1310110061#

http://identifiers.org/biomodels.db/MODEL1310110061#_8853ee66_d1f0_4916_8e63_1965d825a321
is encoded by: hsa:4717
boundary condition: true
initial concentration: NaN
initial amount: NaN
name: NDUFC1
is: SBO:0000252
has only substance units: false
is: O43677
type: Species
constant: false

metaM leuktrC4 e
has only substance units: false
boundary condition: false
is: SBO:0000247
initial amount: NaN
notes: FORMULA: C30H45N3O9S CHARGE: -2 INCHI: InChI=1S/C30H47N3O9S/c1-2-3-4-5-6-7-8-9-10-11-12-13-16-25(24(34)15-14-17-27(36)37)43-21-23(29(40)32-20-28(38)39)33-26(35)19-18-22(31)30(41)42/h6-7,9-13,16,22-25,34H,2-5,8,14-15,17-21,31H2,1H3,(H,32,40)(H,33,35)(H,36,37)(H,38,39)(H,41,42)/p-2/b7-6-,10-9-,12-11+,16-13+/t22-,23-,24-,25+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00898 EHMN_ABBREVIATION: C02166
initial concentration: 1.0
type: Species
constant: false
is: CHEBI:57973
is: HMDB01198
name: leukotriene C4(2-)

http://identifiers.org/biomodels.db/MODEL1310110061#_f2297ca6_4db4_4797_846e_215d377a31ba
initial concentration: NaN
is encoded by: hsa:22934
is: P49247
boundary condition: true
is: SBO:0000252
initial amount: NaN
has only substance units: false
name: RPIA
constant: false
type: Species

metaR OCOAT1m
reactant: MODEL1310110061#
is described by: ECO:0000269
modifier: MODEL1310110061#
reversible: true
fast: false
is version of: http://identifiers.org/ec-code/2.8.3.5
notes: GENE_ASSOCIATION: (5019.1) or (64064.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 2.8.3.5 Confidence Level: 4 AUTHORS: PMID:10964512,PMID:11756565 NOTES:TDV
name: 3-oxoacid CoA-transferase
kinetic law: MODEL1310110061#
product: MODEL1310110061#
is: SBO:0000176
type: Reaction

metaM ins c
is: C00294
boundary condition: false
constant: false
is: CHEBI:17596
is: SBO:0000247
type: Species
has only substance units: false
initial amount: NaN
initial concentration: 1.0
name: Inosine
notes: FORMULA: C10H12N4O5 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00255 EHMN_ABBREVIATION: C00294
is: HMDB00195

metaM cytd e
notes: FORMULA: C9H13N3O5 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00381 EHMN_ABBREVIATION: C00475
has only substance units: false
is: SBO:0000247
is: CHEBI:17562
initial amount: NaN
constant: false
is: HMDB00089
is: C00475
boundary condition: false
type: Species
name: Cytidine
initial concentration: 1.0

metaR FAOXC225m
kinetic law: MODEL1310110061#
product: MODEL1310110061#
reactant: MODEL1310110061#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: isomerization(C22:5)m
type: Reaction

metaM e4p c
initial concentration: 1.0
is: C00279
is: SBO:0000247
notes: FORMULA: C4H7O7P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00247 EHMN_ABBREVIATION: C00279
is: HMDB01321
has only substance units: false
is: CHEBI:16897
boundary condition: false
constant: false
type: Species
initial amount: NaN
name: D-Erythrose 4-phosphate

metaR CITRtm
type: Reaction
kinetic law: MODEL1310110061#
modifier: MODEL1310110061#
notes: GENE_ASSOCIATION: (83884.1) or (10166.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172 NOTES:TDV
product: MODEL1310110061#
is described by: ECO:0000269
reactant: MODEL1310110061#
fast: false
reversible: true
is: SBO:0000185
name: citrulline mitochondrial transport via proton antiport

http://identifiers.org/biomodels.db/MODEL1310110061#_cc24c413_6ca1_4b0a_b330_3a877845a4d6
name: _LOC728997_1_c
boundary condition: true
has only substance units: false
initial concentration: NaN
type: Species
is: SBO:0000252
constant: false
is encoded by: hsa:LOC728997
initial amount: NaN

metaR EX ribflv LPAREN e RPAREN
kinetic law: MODEL1310110061#
reactant: MODEL1310110061#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for Riboflavin
type: Reaction

metaM dhf e
is: SBO:0000247
boundary condition: false
type: Species
notes: FORMULA: C19H19N7O6 CHARGE: -2 INCHI: InChI=1S/C19H21N7O6/c20-19-25-15-14(17(30)26-19)23-11(8-22-15)7-21-10-3-1-9(2-4-10)16(29)24-12(18(31)32)5-6-13(27)28/h1-4,12,21H,5-8H2,(H,24,29)(H,27,28)(H,31,32)(H4,20,22,25,26,30)/p-2/t12-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00340 EHMN_ABBREVIATION: C00415
has only substance units: false
is: HMDB01056
initial concentration: 1.0
name: dihydrofolate(2-)
is: CHEBI:57451
initial amount: NaN
constant: false

http://identifiers.org/biomodels.db/MODEL1310110061#_9e4e6c1e_5b35_4902_8c40_5929e30e6ade
initial concentration: NaN
is: SBO:0000252
is: P11586
constant: false
has only substance units: false
type: Species
is encoded by: hsa:4522
boundary condition: true
initial amount: NaN
name: MTHFD1

metaR EX malthp LPAREN e RPAREN
kinetic law: MODEL1310110061#
reactant: MODEL1310110061#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: maltoheptaose exchange
type: Reaction

metaR r2521
reversible: true
type: Reaction
kinetic law: MODEL1310110061#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:8691743 NOTES:
product: MODEL1310110061#
reactant: MODEL1310110061#
is described by: ECO:0000000
is: SBO:0000185
name: Utilized transport
fast: false

metaM xylt c
boundary condition: false
is: CHEBI:17151
initial amount: NaN
constant: false
notes: FORMULA: C5H12O5 CHARGE: 0 INCHI: InChI=1S/C5H12O5/c6-1-3(8)5(10)4(9)2-7/h3-10H,1-2H2/t3-,4+,5+ HEPATONET_1.0_ABBREVIATION: HC00317 EHMN_ABBREVIATION: C00379
type: Species
is: HMDB02917
is: SBO:0000247
name: xylitol
initial concentration: 1.0
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110061#_0d31e82a_1492_42ff_8aff_de0772a7759a
initial concentration: NaN
is: SBO:0000252
has only substance units: false
type: Species
name: COQ6
boundary condition: true
initial amount: NaN
is: B7Z3K8
is encoded by: hsa:51004
constant: false

metaR EX ha LPAREN e RPAREN
kinetic law: MODEL1310110061#
reactant: MODEL1310110061#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: hyaluronan exchange
type: Reaction

metaM gdp n
initial amount: NaN
constant: false
is: CHEBI:58189
is: HMDB01201
name: GDP(3-)
initial concentration: 1.0
has only substance units: false
is: SBO:0000247
type: Species
notes: FORMULA: C10H12N5O11P2 CHARGE: -3 INCHI: InChI=1S/C10H15N5O11P2/c11-10-13-7-4(8(18)14-10)12-2-15(7)9-6(17)5(16)3(25-9)1-24-28(22,23)26-27(19,20)21/h2-3,5-6,9,16-17H,1H2,(H,22,23)(H2,19,20,21)(H3,11,13,14,18)/p-3/t3-,5-,6-,9-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00043 EHMN_ABBREVIATION: C00035
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110061#_dedaf0ff_99a8_4956_b4b1_2e6070b91463
constant: false
initial concentration: NaN
is: SBO:0000252
boundary condition: true
type: Species
name: COX7A1
is encoded by: hsa:1346
is: P24310
initial amount: NaN
has only substance units: false

metaM zym int2 r
initial amount: NaN
is: CHEBI:52386
type: Species
is: SBO:0000247
has only substance units: false
constant: false
name: zymosterol intermediate 2
boundary condition: false
initial concentration: 1.0
notes: FORMULA: C27H42O CHARGE: 0 INCHI: InChI=1S/C27H42O/c1-18(2)7-6-8-19(3)23-11-12-24-22-10-9-20-17-21(28)13-15-26(20,4)25(22)14-16-27(23,24)5/h7,19-20,23-24H,6,8-17H2,1-5H3/t19-,20+,23-,24+,26+,27-/m1/s1

metaM pan4p e
name: Pantetheine 4'-phosphate
initial concentration: 1.0
notes: FORMULA: C11H21N2O7PS CHARGE: -2
is: HMDB01416
is: CHEBI:47942
has only substance units: false
boundary condition: false
type: Species
is: SBO:0000247
is: C01134
initial amount: NaN
constant: false

metaR EX HC00822 LPAREN e RPAREN
kinetic law: MODEL1310110061#
reactant: MODEL1310110061#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Chitobiose exchange
type: Reaction

metaR PMEVKc
is: SBO:0000176
is described by: ECO:0000134
fast: false
name: phosphomevalonate kinase, cytosol
type: Reaction
notes: GENE_ASSOCIATION: (10654.1) SUBSYSTEM: Squalene and cholesterol synthesis EC Number: Confidence Level: 4 AUTHORS: Davidson, N. O., Magun, A. M. and Glickman, R. M. 2011. Enterocyte Lipid Absorption and Secretion. Comprehensive Physiology. 505?526, PMID: 17015489, PMID: 18216769, PMID: 6833883, PMID: 11229876. NOTES:Enterocytes stand next to liver in endogenous cholesterol synthesis. in rats they provide 25% of bodys cholesterol. the crypt epithelial cells synthesize maximum cholesterol when compared to other parts of the GI tract (PMCID: PMC292609). Reactions till farnesyl pyrophosphate operates in cytosol, however, further steps including squalene synthase operates in E.R (Harpers illustrated Biochemistry (2009) 28th edition, Lange medical publications, chapter 26, page 224-227). all the cholesterol synthesis enzymes have also been found in peroxisomes (PMID: 12121718), no evidence for enterocyte sub-cellular sites, so cytosolic reactions have been added according to Harper book. one proton added to substrate for elemental balancing.
product: MODEL1310110061#
reversible: false
reactant: MODEL1310110061#
is version of: http://identifiers.org/ec-code/2.7.4.2
modifier: MODEL1310110061#
kinetic law: MODEL1310110061#

http://identifiers.org/biomodels.db/MODEL1310110061#_d801a0eb_f879_40bb_a995_9dc2dc3ddea5
boundary condition: true
type: Species
has only substance units: false
initial concentration: NaN
name: _22305_2_c
is encoded by: hsa:22305
is: SBO:0000252
initial amount: NaN
constant: false

metaR CYANt
product: MODEL1310110061#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:assumed to be readily diffusible MM
fast: false
type: Reaction
kinetic law: MODEL1310110061#
name: Cyanide transport via diffusion (extracellular to cytosol)
reactant: MODEL1310110061#
is described by: ECO:0000000
reversible: true

metaM 5HPET c
boundary condition: false
notes: FORMULA: C20H31O4 CHARGE: -1 INCHI: InChI=1S/C20H32O4/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-16-19(24-23)17-15-18-20(21)22/h6-7,9-10,12-14,16,19,23H,2-5,8,11,15,17-18H2,1H3,(H,21,22)/p-1/b7-6-,10-9-,13-12-,16-14+/t19-/m1/s1
has only substance units: false
is: HMDB01193
constant: false
type: Species
is: CHEBI:57450
initial amount: NaN
name: 5(S)-HPETE(1-)
is: SBO:0000247
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110061#_9455b823_7ed5_4b23_98d5_7d682ea07645
is: SBO:0000252
initial concentration: NaN
constant: false
boundary condition: true
is: Q8WZ48
type: Species
is encoded by: hsa:1374
has only substance units: false
initial amount: NaN
name: CPT1A

metaR r1617
reversible: true
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
notes: GENE_ASSOCIATION: (19.1) or (AL038231.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
kinetic law: MODEL1310110061#
product: MODEL1310110061#
reactant: MODEL1310110061#
type: Reaction
is: SBO:0000185
fast: false
is described by: ECO:0000000
modifier: MODEL1310110061#

metaR DAGKn hs
name: Diacylglycerol phosphate kinase (homo sapiens)
reversible: true
modifier: MODEL1310110061#
is: SBO:0000176
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/2.7.1.107
notes: GENE_ASSOCIATION: (8525.1) or (9162.1) SUBSYSTEM: Glycerophospholipid metabolism EC Number: 2.7.1.107 Confidence Level: 4 AUTHORS: NOTES:NJ
reactant: MODEL1310110061#
fast: false
kinetic law: MODEL1310110061#
type: Reaction
product: MODEL1310110061#

metaR PTCRTD
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID: 9505881, PMID: 11564949 NOTES:putriscine uptake by the cells via passive diffusion, reported to be more rapid at the basolateral side.
kinetic law: MODEL1310110061#
type: Reaction
product: MODEL1310110061#
reactant: MODEL1310110061#
reversible: true
is: SBO:0000185
name: diffusion of putriscine into the endothelial cells
is described by: ECO:0000134

metaR ACACT10m
reactant: MODEL1310110061#
reversible: true
is version of: http://identifiers.org/ec-code/2.3.1.9
notes: GENE_ASSOCIATION: (38.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 2.3.1.9 Confidence Level: 4 AUTHORS: PMID:676035 NOTES:MM. 2-Methyl-3-acetoacetyl-CoA excreted into urine for patients with disease deficiency
is: SBO:0000176
type: Reaction
kinetic law: MODEL1310110061#
is described by: ECO:0000134
fast: false
name: acetyl-CoA C-acetyltransferase, mitochondrial
modifier: MODEL1310110061#
product: MODEL1310110061#

http://identifiers.org/biomodels.db/MODEL1310110061#_ff6cfe29_8ee9_4dfb_a4c6_5158568fe94a
is encoded by: hsa:U37519
boundary condition: true
initial amount: NaN
has only substance units: false
constant: false
is: SBO:0000252
type: Species
initial concentration: NaN
name: _U37519_1_m

http://identifiers.org/biomodels.db/MODEL1310110061#_5edc939f_9445_484e_8de3_7d756cd75d99
has only substance units: false
is encoded by: hsa:29968
is: SBO:0000252
constant: false
type: Species
initial concentration: NaN
name: PSAT1
initial amount: NaN
boundary condition: true

metaR FAOXTC122TC101m
kinetic law: MODEL1310110061#
product: MODEL1310110061#
reactant: MODEL1310110061#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation trans(C12:2-->C10:1)m
type: Reaction

metaM gdp m
notes: FORMULA: C10H12N5O11P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00043 EHMN_ABBREVIATION: C00035
initial amount: NaN
constant: false
has only substance units: false
boundary condition: false
name: GDP
is: SBO:0000247
is: C00035
type: Species
is: CHEBI:58189
is: HMDB01201
initial concentration: 1.0

metaM leuktrC4 c
notes: FORMULA: C30H45N3O9S CHARGE: -2 INCHI: InChI=1S/C30H47N3O9S/c1-2-3-4-5-6-7-8-9-10-11-12-13-16-25(24(34)15-14-17-27(36)37)43-21-23(29(40)32-20-28(38)39)33-26(35)19-18-22(31)30(41)42/h6-7,9-13,16,22-25,34H,2-5,8,14-15,17-21,31H2,1H3,(H,32,40)(H,33,35)(H,36,37)(H,38,39)(H,41,42)/p-2/b7-6-,10-9-,12-11+,16-13+/t22-,23-,24-,25+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00898 EHMN_ABBREVIATION: C02166
boundary condition: false
initial concentration: 1.0
is: SBO:0000247
initial amount: NaN
type: Species
name: leukotriene C4(2-)
constant: false
is: CHEBI:57973
is: HMDB01198
has only substance units: false

metaM tcynt c
type: Species
notes: FORMULA: CNS CHARGE: -1 INCHI: InChI=1S/CHNS/c2-1-3/h3H/p-1 EHMN_ABBREVIATION: C01755
initial concentration: 1.0
is: SBO:0000247
is: HMDB01453
is: CHEBI:18022
has only substance units: false
initial amount: NaN
constant: false
boundary condition: false
name: thiocyanate

http://identifiers.org/biomodels.db/MODEL1310110061#_d65908a3_dccd_464e_b7ec_24ac166c56e9
is: SBO:0000252
initial concentration: NaN
type: Species
is encoded by: hsa:3158
is: P54868
has only substance units: false
name: HMGCS2
boundary condition: true
constant: false
initial amount: NaN

metaM Asn X Ser Thr l
type: Species
is: C01342
name: protein-linked asparagine residue (N-glycosylation site)
boundary condition: false
is: HMDB00051
has only substance units: false
initial concentration: 1.0
constant: false
is: CHEBI:28938
initial amount: NaN
notes: FORMULA: XH CHARGE: 0
is: SBO:0000247

metaR EX his L LPAREN e RPAREN
kinetic law: MODEL1310110061#
reactant: MODEL1310110061#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for L-histidine
type: Reaction

metaR r1618
product: MODEL1310110061#
is described by: ECO:0000000
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
notes: GENE_ASSOCIATION: (19.1) or (AL038231.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reversible: true
is: SBO:0000185
fast: false
modifier: MODEL1310110061#
reactant: MODEL1310110061#
kinetic law: MODEL1310110061#
type: Reaction

metaR DPPS
fast: false
type: Reaction
reactant: MODEL1310110061#
product: MODEL1310110061#
is: SBO:0000176
is described by: ECO:0000134
kinetic law: MODEL1310110061#
notes: GENE_ASSOCIATION: SUBSYSTEM: Miscellaneous EC Number: Confidence Level: 2 AUTHORS: PMID:16262699 NOTES:by analogy to other dimethyl transferase rxns. See PMID: 10586494, human interemidate (from C15 ->C50) not explicitly determined yet, however it is known to occur since this pathway is essential in Q10 synthesis. For human metabolism: may be associated w/ GeneID: 23590 TPRT - recheck lit in future IT and NJ
reversible: false
name: decaprenyl synthase

metaR RETFA
is: SBO:0000176
reversible: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Vitamin A metabolism EC Number: 2.3.1.76 Confidence Level: 2 AUTHORS: PMID:1503811 NOTES:IT
kinetic law: MODEL1310110061#
type: Reaction
name: retinol acyltransferase
product: MODEL1310110061#
reactant: MODEL1310110061#
fast: false
is described by: ECO:0000000

metaR 3DPHBH2
fast: false
is described by: ECO:0000000
type: Reaction
reactant: MODEL1310110061#
product: MODEL1310110061#
name: Hydroxylation of 3-Decaprenyl-4-hydroxybenzoate (NADPH)
kinetic law: MODEL1310110061#
is: SBO:0000176
reversible: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Ubiquinone synthesis EC Number: Confidence Level: 2 AUTHORS: PMID:11051212 NOTES:Used to make Ubiquinone-10 enzyme has not been identified yet. IT

http://identifiers.org/biomodels.db/MODEL1310110061#_9d218b77_9e1f_4c73_9acf_ffd477297ae1
is: SBO:0000252
is: P30520
constant: false
is encoded by: hsa:159
name: ADSS
initial amount: NaN
has only substance units: false
initial concentration: NaN
type: Species
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110061#_2c74cb28_3cae_4264_8026_bd0c1fa06b25
type: Species
initial concentration: NaN
constant: false
boundary condition: true
initial amount: NaN
name: ELOVL4
has only substance units: false
is encoded by: hsa:6785
is: Q9GZR5
is: SBO:0000252

metaR r1156
is: SBO:0000176
is described by: ECO:0000000
fast: false
reactant: MODEL1310110061#
notes: GENE_ASSOCIATION: SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.1.48 Confidence Level: 0 AUTHORS: PMID:11306702,PMID:11494055,PMID:64250,PMID:9923963 NOTES:
type: Reaction
product: MODEL1310110061#
kinetic law: MODEL1310110061#
reversible: true
name: dUTP:uridine 5-phosphotransferase Pyrimidine metabolism EC:2.7.1.48

http://identifiers.org/biomodels.db/MODEL1310110061#_a21c7ddd_a4a0_418b_94dc_78019254160b
has only substance units: false
initial concentration: NaN
type: Species
boundary condition: true
is: SBO:0000252
constant: false
initial amount: NaN
name: ACADVL
is encoded by: hsa:37
is: P49748

metaM 34hpl m
is: CHEBI:36659
initial amount: NaN
type: Species
is: HMDB00755
name: 3-(4-hydroxyphenyl)lactate
initial concentration: 1.0
boundary condition: false
is: SBO:0000247
has only substance units: false
notes: FORMULA: C9H9O4 CHARGE: -1 INCHI: InChI=1S/C9H10O4/c10-7-3-1-6(2-4-7)5-8(11)9(12)13/h1-4,8,10-11H,5H2,(H,12,13)/p-1
constant: false

metaM orn e
initial concentration: 1.0
boundary condition: false
notes: FORMULA: C5H13N2O2 CHARGE: 1
has only substance units: false
is: SBO:0000247
initial amount: NaN
is: HMDB00214
type: Species
is: CHEBI:0
is: C01602
constant: false
name: Ornithine

metaM acgam r
constant: false
is: SBO:0000247
boundary condition: false
is: CHEBI:17411
notes: FORMULA: C8H15NO6 CHARGE: 0 INCHI: InChI=1S/C8H15NO6/c1-4(12)9-5(2-10)7(14)8(15)6(13)3-11/h2,5-8,11,13-15H,3H2,1H3,(H,9,12)/t5-,6+,7+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00138 EHMN_ABBREVIATION: C00140
has only substance units: false
type: Species
is: HMDB00215
initial amount: NaN
initial concentration: 1.0
name: N-acetyl-D-glucosamine

metaM hLkynr c
constant: false
name: 3-hydroxy-L-kynurenine
initial amount: NaN
initial concentration: 1.0
is: HMDB11631
has only substance units: false
is: SBO:0000247
type: Species
is: CHEBI:17380
boundary condition: false
notes: FORMULA: C10H12N2O4 CHARGE: 0 INCHI: InChI=1S/C10H12N2O4/c11-6(10(15)16)4-8(14)5-2-1-3-7(13)9(5)12/h1-3,6,13H,4,11-12H2,(H,15,16)/t6-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01079 EHMN_ABBREVIATION: C03227

metaR RPEc
reversible: true
name: ribulose 5-phosphate 3-epimerase
reactant: MODEL1310110061#
kinetic law: MODEL1310110061#
notes: GENE_ASSOCIATION: SUBSYSTEM: Pentose phosphate pathway EC Number: 5.1.3.1 Confidence Level: 4 AUTHORS: PMID: 4382012, PMID: 13575411, Harpers illustrated Biochemistry (2009) 28th edition pages 174-183 NOTES:coefficient changed to 2
is: SBO:0000176
fast: false
type: Reaction
is described by: ECO:0000134
product: MODEL1310110061#

metaR EX 5adtststerones LPAREN e RPAREN
kinetic law: MODEL1310110061#
reactant: MODEL1310110061#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 5alpha-Dihydrotestosterone sulfate exchange
type: Reaction

metaR CYSSERNaEx
is described by: ECO:0000269
product: MODEL1310110061#
type: Reaction
modifier: MODEL1310110061#
notes: GENE_ASSOCIATION: (6509.1) or (6510.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14530974 NOTES:SAB see Kanai and Hediger 2004 (2003), PMID 14530974
name: L-serine/L-cysteine Na-dependent exchange (Cys-L in)
is: SBO:0000185
reversible: false
reactant: MODEL1310110061#
fast: false
kinetic law: MODEL1310110061#

metaR r1260
type: Reaction
fast: false
name: EC:6.2.1.3
is: SBO:0000176
product: MODEL1310110061#
is described by: ECO:0000000
kinetic law: MODEL1310110061#
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 0 AUTHORS: PMID:8584017 NOTES:
reactant: MODEL1310110061#
reversible: false

metaM C05279 m
is: HMDB11123
constant: false
is: SBO:0000247
name: trans,cis-Lauro-2,6-dienoyl-CoA
has only substance units: false
notes: FORMULA: C33H50N7O17P3S CHARGE: -4 INCHI: InChI=1S/C33H54N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-24(42)61-17-16-35-23(41)14-15-36-31(45)28(44)33(2,3)19-54-60(51,52)57-59(49,50)53-18-22-27(56-58(46,47)48)26(43)32(55-22)40-21-39-25-29(34)37-20-38-30(25)40/h8-9,12-13,20-22,26-28,32,43-44H,4-7,10-11,14-19H2,1-3H3,(H,35,41)(H,36,45)(H,49,50)(H,51,52)(H2,34,37,38)(H2,46,47,48)/b9-8-,13-12+/t22-,26-,27-,28+,32-/m1/s1 EHMN_ABBREVIATION: C05279
boundary condition: false
is: CHEBI:28387
initial amount: NaN
initial concentration: 1.0
type: Species

metaR r1615
is: SBO:0000185
modifier: MODEL1310110061#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reversible: true
fast: false
kinetic law: MODEL1310110061#
notes: GENE_ASSOCIATION: (19.1) or (AL038231.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
type: Reaction
reactant: MODEL1310110061#
is described by: ECO:0000000
product: MODEL1310110061#

metaM mescoa m
boundary condition: false
initial amount: NaN
constant: false
initial concentration: 1.0
is: SBO:0000247
has only substance units: false
notes: FORMULA: C26H35N7O19P3S CHARGE: -5 INCHI: InChI=1S/C26H40N7O19P3S/c1-13(8-16(35)36)25(40)56-7-6-28-15(34)4-5-29-23(39)20(38)26(2,3)10-49-55(46,47)52-54(44,45)48-9-14-19(51-53(41,42)43)18(37)24(50-14)33-12-32-17-21(27)30-11-31-22(17)33/h8,11-12,14,18-20,24,37-38H,4-7,9-10H2,1-3H3,(H,28,34)(H,29,39)(H,35,36)(H,44,45)(H,46,47)(H2,27,30,31)(H2,41,42,43)/b13-8+/t14-,18-,19-,20+,24-/m1/s1
is: CHEBI:27969
type: Species
name: Mesaconyl-CoA
is: C06028

metaR EX 3mop LPAREN e RPAREN
kinetic law: MODEL1310110061#
reactant: MODEL1310110061#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: Exchange of 3-methyl-2-oxopentanoate
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110061#_b5a09713_66ce_4601_81c9_4b830dc378f5
is: SBO:0000252
is: Q6GTM5
has only substance units: false
type: Species
initial amount: NaN
constant: false
initial concentration: NaN
is encoded by: hsa:6309
name: SC5DL
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110061#_5de02700_482c_4b0a_a6aa_01682659a7d4
is: Q8WYR1
constant: false
type: Species
is encoded by: hsa:23533
initial amount: NaN
name: PIK3R5
boundary condition: true
is: SBO:0000252
initial concentration: NaN
has only substance units: false

metaM 4mzym int1 r
notes: FORMULA: C29H46O3 CHARGE: 0 INCHI: InChI=1/C29H46O3/c1-18(2)8-7-9-19(3)21-11-12-22-20-10-13-24-28(5,23(20)14-16-27(21,22)4)17-15-25(30)29(24,6)26(31)32/h8,19,21-22,24-25,30H,7,9-17H2,1-6H3,(H,31,32)/t19-,21?,22?,24?,25-,27+,28+,29-/m0/s1
is: SBO:0000247
initial amount: NaN
type: Species
constant: false
name: 4-Methylzymosterol intermediate 1
has only substance units: false
initial concentration: 1.0
is: HMDB06927
boundary condition: false

metaM 6a2ohxnt x
initial amount: NaN
is: HMDB12151
is: SBO:0000247
type: Species
has only substance units: false
initial concentration: 1.0
constant: false
notes: FORMULA: C6H11NO3 CHARGE: 0 INCHI: InChI=1S/C6H11NO3/c7-4-2-1-3-5(8)6(9)10/h1-4,7H2,(H,9,10) EHMN_ABBREVIATION: C03239
is: CHEBI:17534
boundary condition: false
name: 6-amino-2-oxohexanoic acid

metaR GALASE19ly
is version of: http://identifiers.org/ec-code/3.4.16.5
kinetic law: MODEL1310110061#
is version of: http://identifiers.org/ec-code/3.1.6.4
is version of: http://identifiers.org/ec-code/3.2.1.23
reactant: MODEL1310110061#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.2.1.18
modifier: MODEL1310110061#
name: beta-galactosidase, lysosomal
product: MODEL1310110061#
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) or (5476.1) and (2720.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.18 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD
reversible: false
is described by: ECO:0000269
fast: false
type: Reaction

metaR LNELDCCRNt
name: transport into the mitochondria (carnitine)
reversible: false
is described by: ECO:0000000
kinetic law: MODEL1310110061#
type: Reaction
notes: GENE_ASSOCIATION: (788.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: NOTES:NJ
product: MODEL1310110061#
reactant: MODEL1310110061#
modifier: MODEL1310110061#
is: SBO:0000185
fast: false

metaM tcynt e
is: HMDB01453
notes: FORMULA: CNS CHARGE: -1 INCHI: InChI=1S/CHNS/c2-1-3/h3H/p-1 EHMN_ABBREVIATION: C01755
has only substance units: false
type: Species
name: thiocyanate
boundary condition: false
initial amount: NaN
initial concentration: 1.0
constant: false
is: SBO:0000247
is: CHEBI:18022

metaR CMPACNAtn
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: NOTES:NCD
kinetic law: MODEL1310110061#
name: CMP-Sia nuclear export
type: Reaction
reactant: MODEL1310110061#
fast: false
is described by: ECO:0000000
product: MODEL1310110061#
reversible: false

metaR ALOX52
fast: false
is version of: http://identifiers.org/ec-code/1.13.11.34
name: Arachidonate 5-lipoxygenase
is described by: ECO:0000269
kinetic law: MODEL1310110061#
is: SBO:0000176
product: MODEL1310110061#
reversible: false
reactant: MODEL1310110061#
type: Reaction
notes: GENE_ASSOCIATION: (240.1) SUBSYSTEM: Eicosanoid metabolism EC Number: 1.13.11.34 Confidence Level: 4 AUTHORS: PMID:11160764 NOTES:cofactors + usage still not clear unknown mechanism - biochemistry supported by PMID: 2829172, 11160764
modifier: MODEL1310110061#

metaR EX dopa LPAREN e RPAREN
kinetic law: MODEL1310110061#
reactant: MODEL1310110061#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Dopamine exchange
type: Reaction

metaM n2m2nm l
type: Species
is: HMDB00573
name: n2m2nmasn (w/o peptide linkage)
is: CHEBI:30825
initial amount: NaN
constant: false
initial concentration: 1.0
notes: FORMULA: C58H97N5O41 CHARGE: 0
is: SBO:0000247
has only substance units: false
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110061#_2f560d5e_3a44_48e3_b5cf_e0b46b49b171
is: SBO:0000252
name: SLC5A7
initial amount: NaN
boundary condition: true
is: Q9GZV3
is encoded by: hsa:60482
constant: false
type: Species
has only substance units: false
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110061#_fcff3be6_01d3_4fb0_9477_7e839d2d6189
is encoded by: hsa:2639
initial concentration: NaN
type: Species
is: SBO:0000252
is: Q92947
has only substance units: false
initial amount: NaN
constant: false
name: GCDH
boundary condition: true

metaM gdp g
boundary condition: false
has only substance units: false
is: SBO:0000247
is: CHEBI:58189
type: Species
is: HMDB01201
initial concentration: 1.0
name: GDP(3-)
notes: FORMULA: C10H12N5O11P2 CHARGE: -3 INCHI: InChI=1S/C10H15N5O11P2/c11-10-13-7-4(8(18)14-10)12-2-15(7)9-6(17)5(16)3(25-9)1-24-28(22,23)26-27(19,20)21/h2-3,5-6,9,16-17H,1H2,(H,22,23)(H2,19,20,21)(H3,11,13,14,18)/p-3/t3-,5-,6-,9-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00043 EHMN_ABBREVIATION: C00035
constant: false
initial amount: NaN

metaR r1154
is: SBO:0000176
is described by: ECO:0000000
fast: false
type: Reaction
reactant: MODEL1310110061#
product: MODEL1310110061#
name: EC:1.2.7.2
notes: GENE_ASSOCIATION: SUBSYSTEM: Propanoate metabolism EC Number: 1.2.7.2 Confidence Level: 0 AUTHORS: PMID:2649080,PMID:283398,PMID:3718468,PMID:9381974 NOTES:
kinetic law: MODEL1310110061#
reversible: true

metaM for e
is: CHEBI:15740
has only substance units: false
name: formate
constant: false
is: SBO:0000247
initial concentration: 1.0
type: Species
is: HMDB00142
boundary condition: false
initial amount: NaN
notes: FORMULA: CH1O2 CHARGE: -1 INCHI: InChI=1S/CH2O2/c2-1-3/h1H,(H,2,3)/p-1 HEPATONET_1.0_ABBREVIATION: HC00061 EHMN_ABBREVIATION: C00058

metaR r1616
is described by: ECO:0000000
reversible: true
notes: GENE_ASSOCIATION: (19.1) or (AL038231.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
fast: false
is: SBO:0000185
modifier: MODEL1310110061#
kinetic law: MODEL1310110061#
type: Reaction
product: MODEL1310110061#
reactant: MODEL1310110061#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1

metaR DLNLCGt
fast: false
name: fatty acid transport via diffusion
reactant: MODEL1310110061#
kinetic law: MODEL1310110061#
is described by: ECO:0000000
is: SBO:0000185
reversible: true
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11788354,PMID:12864740 NOTES:NJ
product: MODEL1310110061#

metaR EX 4abutn LPAREN e RPAREN
kinetic law: MODEL1310110061#
reactant: MODEL1310110061#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of 4-ammoniobutanal
type: Reaction

metaM nrpphr e
is: HMDB00216
constant: false
type: Species
notes: FORMULA: C8H12NO3 CHARGE: 1 INCHI: InChI=1S/C8H11NO3/c9-4-8(12)5-1-2-6(10)7(11)3-5/h1-3,8,10-12H,4,9H2 HEPATONET_1.0_ABBREVIATION: HC00426 EHMN_ABBREVIATION: C00547
boundary condition: false
is: CHEBI:33569
has only substance units: false
initial amount: NaN
is: SBO:0000247
initial concentration: 1.0
name: Norepinephrine

metaR L LACt2r
kinetic law: MODEL1310110061#
name: L-lactate reversible transport via proton symport
modifier: MODEL1310110061#
product: MODEL1310110061#
type: Reaction
notes: GENE_ASSOCIATION: (9194.1) or (23539.1) or (6566.1) or (9123.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10493836,PMID:10510291,PMID:11101640,PMID:11827462,PMID:12739169,PMID:7835905,PMID:8476015,PMID:9425115,PMID:9508842,PMID:9649795,PMID:9786900,PMID:9824713 NOTES:NCD
fast: false
reversible: true
is described by: ECO:0000269
is: SBO:0000185
reactant: MODEL1310110061#

metaM mi1p D n
is: HMDB02985
initial amount: NaN
is: SBO:0000247
name: 1D-myo-inositol 1-phosphate(2-)
has only substance units: false
boundary condition: false
constant: false
type: Species
notes: FORMULA: C6H11O9P CHARGE: -2 INCHI: InChI=1S/C6H13O9P/c7-1-2(8)4(10)6(5(11)3(1)9)15-16(12,13)14/h1-11H,(H2,12,13,14)/p-2/t1-,2-,3+,4-,5-,6-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00698
initial concentration: 1.0
is: CHEBI:58433

metaR ACHEe
reversible: false
reactant: MODEL1310110061#
is: SBO:0000176
notes: GENE_ASSOCIATION: (43.1) or (43.2) SUBSYSTEM: Glycerophospholipid metabolism EC Number: 3.1.1.7 Confidence Level: 4 AUTHORS: PMID:11283752,PMID:1517212 NOTES:NJ
name: Acetylcholinesterase
type: Reaction
product: MODEL1310110061#
kinetic law: MODEL1310110061#
is version of: http://identifiers.org/ec-code/3.1.1.7
fast: false
modifier: MODEL1310110061#
is described by: ECO:0000269

metaM odecoa r
initial concentration: 1.0
boundary condition: false
constant: false
initial amount: NaN
name: oleoyl-CoA(4-)
is: HMDB01322
is: CHEBI:57387
has only substance units: false
notes: FORMULA: C39H64N7O17P3S CHARGE: -4 INCHI: InChI=1S/C39H68N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-30(48)67-23-22-41-29(47)20-21-42-37(51)34(50)39(2,3)25-60-66(57,58)63-65(55,56)59-24-28-33(62-64(52,53)54)32(49)38(61-28)46-27-45-31-35(40)43-26-44-36(31)46/h11-12,26-28,32-34,38,49-50H,4-10,13-25H2,1-3H3,(H,41,47)(H,42,51)(H,55,56)(H,57,58)(H2,40,43,44)(H2,52,53,54)/p-4/b12-11-/t28-,32-,33-,34+,38-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00400 EHMN_ABBREVIATION: C00510
is: SBO:0000247
type: Species

metaR RE1525M
is version of: http://identifiers.org/ec-code/1.1.1.35
product: MODEL1310110061#
reactant: MODEL1310110061#
reversible: true
notes: GENE_ASSOCIATION: (3295.1) or (1962.1) or (3033.1) or (3028.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.1.1.35 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:7775433 NOTES:
fast: false
kinetic law: MODEL1310110061#
is version of: http://identifiers.org/ec-code/4.2.1.107
modifier: MODEL1310110061#
is: SBO:0000176
type: Reaction
name: RE1525
is described by: ECO:0000000

metaR PGI
is described by: ECO:0000134
is: SBO:0000176
product: MODEL1310110061#
notes: GENE_ASSOCIATION: (2821.1) SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: 5.3.1.9 Confidence Level: 0 AUTHORS: PMID:19064002,PMID:2241164,PMID:8530082 NOTES:
kinetic law: MODEL1310110061#
type: Reaction
fast: false
modifier: MODEL1310110061#
name: glucose-6-phosphate isomerase
reactant: MODEL1310110061#
reversible: true
is version of: http://identifiers.org/ec-code/5.3.1.9

http://identifiers.org/biomodels.db/MODEL1310110061#_01f3c3b1_b6bb_4156_8149_cca5ddae47fd
constant: false
is: SBO:0000297
is encoded by: hsa:3906
name: B4GALT1:LALBA
has part: P00709
boundary condition: true
initial amount: NaN
type: Species
has only substance units: false
initial concentration: NaN
is encoded by: hsa:2683
has part: P15291

http://identifiers.org/biomodels.db/MODEL1310110061#_6afb11e0_1a6c_4281_a657_d18f53f16583
initial concentration: NaN
is: SBO:0000252
constant: false
is encoded by: hsa:114112
initial amount: NaN
name: TXNRD3
has only substance units: false
boundary condition: true
type: Species
is: Q86VQ6

metaR EX prpp LPAREN e RPAREN
kinetic law: MODEL1310110061#
reactant: MODEL1310110061#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of 5-O-phosphonato-alpha-D-ribofuranosyl diphosphate(5-)
type: Reaction

metaR C226COAtx
reversible: true
product: MODEL1310110061#
is: SBO:0000185
reactant: MODEL1310110061#
kinetic law: MODEL1310110061#
name: fatty acid intracellular transport
fast: false
is described by: ECO:0000000
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: NOTES:interaction between peroxisomes and ER (some enzymes on the outer membrane) NJ

metaM ha l
type: Species
constant: false
initial amount: NaN
name: hyaluronan
has only substance units: false
notes: FORMULA: C28H40N2O22 CHARGE: -2 EHMN_ABBREVIATION: C00518
initial concentration: 1.0
is: CHEBI:16336
boundary condition: false
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110061#_80726a26_9ea6_484b_8661_0938d8e51ca0
is: SBO:0000252
name: PIP4K2C
is: B3KQV3
has only substance units: false
boundary condition: true
is encoded by: hsa:79837
type: Species
initial concentration: NaN
constant: false
initial amount: NaN

metaR DHAPtc
name: transport of DHAP into cytosol
is described by: ECO:0000134
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: NOTES:
is: SBO:0000185
type: Reaction
reactant: MODEL1310110061#
product: MODEL1310110061#
kinetic law: MODEL1310110061#
reversible: false
fast: false

metaR EX asn L LPAREN e RPAREN
kinetic law: MODEL1310110061#
reactant: MODEL1310110061#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for L-asparagine
type: Reaction

metaR EX glyc LPAREN e RPAREN
kinetic law: MODEL1310110061#
reactant: MODEL1310110061#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Glycerol exchange
type: Reaction

metaR URIK1
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (7371.1) or (83549.1) SUBSYSTEM: Pyrimidine synthesis EC Number: 2.7.1.48 Confidence Level: 4 AUTHORS: PMID:11306702,PMID:12199906,PMID:8812458 NOTES:
fast: false
modifier: MODEL1310110061#
reversible: false
reactant: MODEL1310110061#
name: uridine kinase (ATP:Uridine)
type: Reaction
kinetic law: MODEL1310110061#
is version of: http://identifiers.org/ec-code/2.7.1.48
is: SBO:0000176
product: MODEL1310110061#

metaR r1613
is described by: ECO:0000000
is: SBO:0000185
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
modifier: MODEL1310110061#
notes: GENE_ASSOCIATION: (19.1) or (AL038231.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reversible: true
kinetic law: MODEL1310110061#
fast: false
product: MODEL1310110061#
reactant: MODEL1310110061#
type: Reaction

metaR ATP1ter
type: Reaction
fast: false
kinetic law: MODEL1310110061#
is described by: ECO:0000000
name: ADP/ATP transporter, endoplasmic reticulum
product: MODEL1310110061#
reactant: MODEL1310110061#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: NOTES:NCD
is: SBO:0000185
reversible: true

metaR SPHS1Ptr
product: MODEL1310110061#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: PMID:15052333,PMID:15585321 NOTES:unknown mechanism, however sphs1p is known to have intracellular and extracellular activity and signal transduction functions (PMID: 10751414 or PMID: 15585321). NJ
is described by: ECO:0000000
kinetic law: MODEL1310110061#
reversible: true
fast: false
name: sphingosine-1-phosphate transport
type: Reaction
reactant: MODEL1310110061#

metaR r0464
is described by: ECO:0000000
is: SBO:0000176
type: Reaction
name: 4-Aminobutyraldehyde:NAD+ oxidoreductase Urea cycle and metabolism of amino groups EC:1.2.1.3
product: MODEL1310110061#
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Glutamate metabolism EC Number: 1.2.1.3 Confidence Level: 0 AUTHORS: PMID:10467734,PMID:11790142,PMID:4817964,PMID:8155713,PMID:8645224,PMID:8786138 NOTES:
kinetic law: MODEL1310110061#
reactant: MODEL1310110061#
fast: false

http://identifiers.org/biomodels.db/MODEL1310110061#_31774172_2cbc_43df_b13d_6cecafe11e89
type: Species
name: AKR1C4
has only substance units: false
is: P17516
boundary condition: true
initial amount: NaN
constant: false
is encoded by: hsa:1109
initial concentration: NaN
is: SBO:0000252

metaR RE1519M
name: RE1519
type: Reaction
fast: false
reactant: MODEL1310110061#
modifier: MODEL1310110061#
is: SBO:0000176
notes: GENE_ASSOCIATION: (33.1) or (51.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.99.13 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:11356167,PMID:8973539 NOTES:
is version of: http://identifiers.org/ec-code/1.3.3.6
kinetic law: MODEL1310110061#
is described by: ECO:0000000
reversible: true
is version of: http://identifiers.org/ec-code/1.3.99.13
product: MODEL1310110061#

metaM man6p c
has only substance units: false
name: D-Mannose 6-phosphate
initial amount: NaN
is: HMDB01078
initial concentration: 1.0
type: Species
notes: FORMULA: C6H11O9P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00246 EHMN_ABBREVIATION: C00275
constant: false
is: CHEBI:17369
boundary condition: false
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110061#_c30d2780_be43_4518_b96d_db9e19ba9498
name: SLCO4A1
is: Q96BD0
has only substance units: false
is: SBO:0000252
type: Species
initial concentration: NaN
constant: false
is encoded by: hsa:28231
initial amount: NaN
boundary condition: true

metaR 3MOPt2im
name: 3-Methyl-2-oxopentanoate mitochondrial transport via proton symport
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:8428987 NOTES:MM
reversible: false
kinetic law: MODEL1310110061#
fast: false
is described by: ECO:0000000
product: MODEL1310110061#
is: SBO:0000185
reactant: MODEL1310110061#
type: Reaction

metaM 3dodtricoa m
is: C05280
name: 3,6,9-dodecatrienoylcoa
is: HMDB03952
notes: FORMULA: C33H48N7O17P3S CHARGE: -4
is: SBO:0000247
initial amount: NaN
constant: false
initial concentration: 1.0
type: Species
boundary condition: false
has only substance units: false

metaM nad c
has only substance units: false
is: HMDB00902
initial amount: NaN
is: C00003
initial concentration: 1.0
name: Nicotinamide adenine dinucleotide
constant: false
is: CHEBI:57540
boundary condition: false
type: Species
is: http://identifiers.org/pubchem.compound/3305
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110061#_9680b8c4_d4e0_489b_8649_e145331a0f0a
is: P51648
initial concentration: NaN
has only substance units: false
is encoded by: hsa:224
is: SBO:0000252
initial amount: NaN
type: Species
constant: false
name: ALDH3A2
boundary condition: true

metaM thr L e
name: L-threonine
boundary condition: false
constant: false
is: CHEBI:16857
type: Species
initial amount: NaN
is: HMDB00167
has only substance units: false
is: SBO:0000247
notes: FORMULA: C4H9NO3 CHARGE: 0 INCHI: InChI=1S/C4H9NO3/c1-2(6)3(5)4(7)8/h2-3,6H,5H2,1H3,(H,7,8)/t2-,3+/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00179
initial concentration: 1.0

metaR MEVK1c
notes: GENE_ASSOCIATION: (4598.1) SUBSYSTEM: Squalene and cholesterol synthesis EC Number: Confidence Level: 4 AUTHORS: Davidson, N. O., Magun, A. M. and Glickman, R. M. 2011. Enterocyte Lipid Absorption and Secretion. Comprehensive Physiology. 505?526, PMID: 17015489, PMID: 18216769, PMID: 6833883, PMID: 11229876. NOTES:Enterocytes stand next to liver in endogenous cholesterol synthesis. in rats they provide 25% of bodys cholesterol. the crypt epithelial cells synthesize maximum cholesterol when compared to other parts of the GI tract (PMCID: PMC292609). Reactions till farnesyl pyrophosphate operates in cytosol, however, further steps including squalene synthase operates in E.R (Harpers illustrated Biochemistry (2009) 28th edition, Lange medical publications, chapter 26, page 224-227). all the cholesterol synthesis enzymes have also been found in peroxisomes (PMID: 12121718), no evidence for enterocyte sub-cellular sites, so cytosolic reactions have been added according to Harper book.
modifier: MODEL1310110061#
is: SBO:0000176
type: Reaction
product: MODEL1310110061#
kinetic law: MODEL1310110061#
is described by: ECO:0000134
is version of: http://identifiers.org/ec-code/2.7.1.36
reversible: false
reactant: MODEL1310110061#
fast: false
name: mevalonate kinase (atp) cytosol

metaR PRAGSr
modifier: MODEL1310110061#
fast: false
is version of: http://identifiers.org/ec-code/2.1.2.2
kinetic law: MODEL1310110061#
product: MODEL1310110061#
is: SBO:0000176
notes: GENE_ASSOCIATION: (2618.1) or (2618.2) SUBSYSTEM: Purine synthesis EC Number: Confidence Level: 4 AUTHORS: NOTES:
reactant: MODEL1310110061#
is described by: ECO:0000269
name: phosphoribosylglycinamide synthase
type: Reaction
reversible: true

metaR r1614
type: Reaction
product: MODEL1310110061#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is described by: ECO:0000000
modifier: MODEL1310110061#
fast: false
notes: GENE_ASSOCIATION: (19.1) or (AL038231.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reversible: true
kinetic law: MODEL1310110061#
is: SBO:0000185
reactant: MODEL1310110061#

metaM nrpphr c
initial amount: NaN
is: SBO:0000247
is: HMDB00216
notes: FORMULA: C8H12NO3 CHARGE: 1 INCHI: InChI=1S/C8H11NO3/c9-4-8(12)5-1-2-6(10)7(11)3-5/h1-3,8,10-12H,4,9H2 HEPATONET_1.0_ABBREVIATION: HC00426 EHMN_ABBREVIATION: C00547
constant: false
type: Species
boundary condition: false
has only substance units: false
is: CHEBI:33569
name: Norepinephrine
initial concentration: 1.0

metaM for c
is: CHEBI:15740
initial concentration: 1.0
constant: false
is: C00058
notes: FORMULA: CH1O2 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00061 EHMN_ABBREVIATION: C00058
is: SBO:0000247
type: Species
name: Formate
boundary condition: false
is: HMDB00142
has only substance units: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110061#_8b058c29_538a_4c7d_9dc7_7b2e5da4a9e8
boundary condition: true
is: D9HTE9
type: Species
constant: false
has only substance units: false
is encoded by: hsa:6576
name: SLC25A1
initial concentration: NaN
is: SBO:0000252
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110061#_1198462b_3727_428b_bf7a_335625a05648
name: CPT2
is: P23786
initial concentration: NaN
type: Species
constant: false
is encoded by: hsa:1376
boundary condition: true
initial amount: NaN
is: SBO:0000252
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110061#_3a35f673_503d_4a97_9d51_09d0035727dd
type: Species
name: PKM2
initial concentration: NaN
has only substance units: false
boundary condition: true
initial amount: NaN
is encoded by: hsa:5315
is: SBO:0000252
constant: false

metaR r0463
is: SBO:0000176
type: Reaction
name: (S)-3-Hydroxy-3-methylglutaryl-CoA acetoacetyl-CoA-lyase (CoA-acetylating) Synthesis and degradation of ketone bodies / Valine, leucine and isoleucine degradation / Butanoate metabolism EC:2.3.3.10
kinetic law: MODEL1310110061#
notes: GENE_ASSOCIATION: SUBSYSTEM: Cholesterol metabolism EC Number: 2.3.3.10 Confidence Level: 0 AUTHORS: PMID:11087424,PMID:11108725,PMID:1358203,PMID:7893153 NOTES:
product: MODEL1310110061#
reactant: MODEL1310110061#
fast: false
reversible: true
is described by: ECO:0000000

metaR PGK
fast: false
is version of: http://identifiers.org/ec-code/2.7.2.3
type: Reaction
modifier: MODEL1310110061#
kinetic law: MODEL1310110061#
reversible: true
notes: GENE_ASSOCIATION: (5230.1) or (375056.1) or (5232.1) SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: Confidence Level: 0 AUTHORS: NOTES:
reactant: MODEL1310110061#
is described by: ECO:0000134
product: MODEL1310110061#
name: phosphoglycerate kinase
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110061#_4c1f317f_c5f1_433d_90d7_16d9241be5e2
boundary condition: true
has only substance units: false
type: Species
is: Q9BV79
name: MECR
is: SBO:0000252
constant: false
is encoded by: hsa:51102
initial concentration: NaN
initial amount: NaN

metaR EX CE5854 LPAREN e RPAREN
kinetic law: MODEL1310110061#
reactant: MODEL1310110061#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: gama-CEHC-glucuronide exchange
type: Reaction

metaM 2dp6mobq m
type: Species
name: 2-decaprenyl-6-methoxy-1,4-benzoquinone
is: SBO:0000247
boundary condition: false
initial concentration: 1.0
notes: FORMULA: C57H86O3 CHARGE: 0 INCHI: InChI=1S/C57H86O3/c1-44(2)22-13-23-45(3)24-14-25-46(4)26-15-27-47(5)28-16-29-48(6)30-17-31-49(7)32-18-33-50(8)34-19-35-51(9)36-20-37-52(10)38-21-39-53(11)40-41-54-42-55(58)43-56(60-12)57(54)59/h22,24,26,28,30,32,34,36,38,40,42-43H,13-21,23,25,27,29,31,33,35,37,39,41H2,1-12H3/b45-24+,46-26+,47-28+,48-30+,49-32+,50-34+,51-36+,52-38+,53-40+
has only substance units: false
initial amount: NaN
is: CHEBI:50773
constant: false

metaM lcts e
is: CHEBI:17716
initial amount: NaN
has only substance units: false
name: Lactose
initial concentration: 1.0
notes: FORMULA: C12H22O11 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00220 EHMN_ABBREVIATION: C00243
is: C00243
boundary condition: false
is: HMDB00186
type: Species
constant: false
is: SBO:0000247

metaR C3STDH1r
type: Reaction
name: C-3 sterol dehydrogenase (4-methylzymosterol)
kinetic law: MODEL1310110061#
is described by: ECO:0000134
fast: false
reversible: false
reactant: MODEL1310110061#
modifier: MODEL1310110061#
notes: GENE_ASSOCIATION: (50814.1) SUBSYSTEM: Cholesterol metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:12829805 NOTES:NCD ER version NJ
is: SBO:0000176
product: MODEL1310110061#
is version of: http://identifiers.org/ec-code/1.1.1.170

metaM glcur c
has only substance units: false
is: SBO:0000247
boundary condition: false
constant: false
is: HMDB00127
initial concentration: 1.0
notes: FORMULA: C6H9O7 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00182 EHMN_ABBREVIATION: C00191
name: D-glucuronate
is: CHEBI:15748
initial amount: NaN
type: Species

metaR GALNTg
reactant: MODEL1310110061#
is version of: http://identifiers.org/ec-code/2.4.1.41
notes: GENE_ASSOCIATION: (26290.1) or (79695.1) or (2589.1) or (50614.1) or (8693.1) or (55568.2) or (114805.1) or (11226.1) or (117248.1) or (11227.1) or (55568.1) or (2590.1) or (51809.1) or (26290.1) or (79623.1) or (63917.1) or (2591.1) SUBSYSTEM: O-glycan synthesis EC Number: 2.4.1.41 Confidence Level: 0 AUTHORS: PMID:10767557,PMID:12417297,PMID:12507512,PMID:12634319,PMID:15147861,PMID:9765313 NOTES:NCD
modifier: MODEL1310110061#
type: Reaction
is described by: ECO:0000000
is: SBO:0000176
kinetic law: MODEL1310110061#
name: GalNAc transferase, Golgi apparatus
reversible: false
product: MODEL1310110061#
fast: false

metaR EX CLPND LPAREN e RPAREN
kinetic law: MODEL1310110061#
reactant: MODEL1310110061#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: clupanodonic acid (docosapentaenoic (n-3)) exchange
type: Reaction

metaM gam c
type: Species
initial amount: NaN
notes: FORMULA: C6H14NO5 CHARGE: 1 HEPATONET_1.0_ABBREVIATION: HC00279 EHMN_ABBREVIATION: C00329
constant: false
initial concentration: 1.0
is: SBO:0000247
is: HMDB01514
has only substance units: false
boundary condition: false
is: C00329
name: D-Glucosamine
is: CHEBI:17315

metaR CHATn
is: SBO:0000176
product: MODEL1310110061#
kinetic law: MODEL1310110061#
modifier: MODEL1310110061#
is version of: http://identifiers.org/ec-code/2.3.1.6
notes: GENE_ASSOCIATION: (1103.4) or (1103.1) or (1103.3) or (1103.2) SUBSYSTEM: Glycerophospholipid metabolism EC Number: 2.3.1.6 Confidence Level: 4 AUTHORS: PMID:10861222 NOTES:NJ
reversible: true
name: Choline O-acetyltransferase
fast: false
reactant: MODEL1310110061#
is described by: ECO:0000269
type: Reaction

metaR r0559
modifier: MODEL1310110061#
reactant: MODEL1310110061#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (1719.1) or (HG2846-HT2983.1) SUBSYSTEM: Unassigned EC Number: 1.2.3.1 Confidence Level: 0 AUTHORS: PMID:11569919,PMID:16143537 NOTES:
reversible: true
fast: false
is version of: http://identifiers.org/ec-code/1.5.1.3
is: SBO:0000176
name: aldehyde oxidase Tyrosine metabolism EC:1.2.3.1
kinetic law: MODEL1310110061#
type: Reaction
product: MODEL1310110061#

metaR HDCAtr
reactant: MODEL1310110061#
kinetic law: MODEL1310110061#
is described by: ECO:0000000
product: MODEL1310110061#
type: Reaction
is: SBO:0000185
fast: false
name: fatty acid transport via diffusion
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11788354,PMID:12864740 NOTES:NJ
reversible: true

metaR EX ttdca LPAREN e RPAREN
kinetic law: MODEL1310110061#
reactant: MODEL1310110061#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for tetradecanoate (n-C14:0)
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110061#_788a29fa_41e8_47ee_b41a_95fee23411ad
name: HSD17B10
initial amount: NaN
is encoded by: hsa:3028
initial concentration: NaN
is: Q99714
boundary condition: true
type: Species
constant: false
has only substance units: false
is: SBO:0000252

metaR EX 4hphac LPAREN e RPAREN
kinetic law: MODEL1310110061#
reactant: MODEL1310110061#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 4-Hydroxyphenylacetate exchange
type: Reaction

metaR r0142
reactant: MODEL1310110061#
modifier: MODEL1310110061#
kinetic law: MODEL1310110061#
is version of: http://identifiers.org/ec-code/3.6.1.5
fast: false
product: MODEL1310110061#
is: SBO:0000176
name: Sulfite:oxygen oxidoreductase Sulfur metabolism EC:1.8.3.1
notes: GENE_ASSOCIATION: (AV717590.1) or (953.1) or (956.1) or (377841.1) SUBSYSTEM: Methionine and cysteine metabolism EC Number: 1.8.3.1 Confidence Level: 0 AUTHORS: PMID:12763039,PMID:16475804,PMID:17459792 NOTES:
type: Reaction
reversible: false
is described by: ECO:0000000

metaM CE2705 n
boundary condition: false
notes: FORMULA: C9H13N5O3 CHARGE: 0 INCHI: InChI=1/C9H13N5O3/c1-3(15)6(16)4-2-11-7-5(12-4)8(17)14-9(10)13-7/h3-4,6,15-16H,2H2,1H3,(H3,10,11,13,14,17)/p+1/t3-,4?,6+/m0/s1 EHMN_ABBREVIATION: CE2705
has only substance units: false
initial amount: NaN
initial concentration: 1.0
type: Species
is: HMDB02281
is: CHEBI:15374
is: SBO:0000247
name: quinonoid dihydrobiopterin
constant: false

metaM 1pipdn2c x
initial amount: NaN
has only substance units: false
type: Species
name: 1-piperideine-2-carboxylate
notes: FORMULA: C6H9NO2 CHARGE: 0 INCHI: InChI=1S/C6H9NO2/c8-6(9)5-3-1-2-4-7-5/h1-4H2,(H,8,9)/p-1 EHMN_ABBREVIATION: C04092
is: HMDB01084
constant: false
is: SBO:0000247
boundary condition: false
is: CHEBI:16187
initial concentration: 1.0

metaM fe3 c
initial concentration: 1.0
boundary condition: false
constant: false
has only substance units: false
is: HMDB12943
is: SBO:0000247
name: Fe3+
notes: FORMULA: Fe CHARGE: 3
type: Species
initial amount: NaN

metaR HACD9m
is version of: http://identifiers.org/ec-code/1.1.1.35
modifier: MODEL1310110061#
type: Reaction
product: MODEL1310110061#
name: 3-hydroxyacyl-CoA dehydrogenase (2-Methylacetoacetyl-CoA), mitochondrial
is described by: ECO:0000134
reversible: true
fast: false
kinetic law: MODEL1310110061#
is: SBO:0000176
reactant: MODEL1310110061#
notes: GENE_ASSOCIATION: (3028.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 1.1.1.35 Confidence Level: 4 AUTHORS: PMID:12872843 NOTES:MM. inborn deficiency enzyme causes accumulation of substrate 3-hydroxy-2-methylbutyric acid

metaR EX Rtotal2 LPAREN e RPAREN
kinetic law: MODEL1310110061#
reactant: MODEL1310110061#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: R total 2 position exchange
type: Reaction

metaR EX CE2839 LPAREN e RPAREN
kinetic law: MODEL1310110061#
reactant: MODEL1310110061#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: maltodecaose exchange
type: Reaction

metaR LCTStg
type: Reaction
fast: false
name: lactose transport from Golgi to extracellular (via vesicle)
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:this reaciton is only found in lactating mammary cells NCD
product: MODEL1310110061#
reactant: MODEL1310110061#
reversible: false
is: SBO:0000185
is described by: ECO:0000000
kinetic law: MODEL1310110061#

metaR r0558
kinetic law: MODEL1310110061#
type: Reaction
product: MODEL1310110061#
reactant: MODEL1310110061#
is described by: ECO:0000000
reversible: true
notes: GENE_ASSOCIATION: (1719.1) or (HG2846-HT2983.1) SUBSYSTEM: Unassigned EC Number: 1.2.1.29 Confidence Level: 0 AUTHORS: PMID:11569919,PMID:16143537 NOTES:
is version of: http://identifiers.org/ec-code/1.5.1.3
modifier: MODEL1310110061#
name: Gentisate aldehyde:NAD+ oxidoreductase Tyrosine metabolism EC:1.2.1.29
is: SBO:0000176
fast: false

metaR DOPAQNISO1
reactant: MODEL1310110061#
product: MODEL1310110061#
is: SBO:0000176
type: Reaction
name: Dopaquinone isomerase 1
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Tyrosine metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:5294951 NOTES:SAB
kinetic law: MODEL1310110061#
fast: false
reversible: true

metaM thymd m
initial concentration: 1.0
has only substance units: false
notes: FORMULA: C10H14N2O5 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00198 EHMN_ABBREVIATION: C00214
is: HMDB00273
name: Thymidine
initial amount: NaN
constant: false
is: SBO:0000247
type: Species
boundary condition: false
is: C00214
is: CHEBI:17748

metaR r0355
name: Glycolysis / Glyconeogenesis EC:2.7.1.1
reversible: false
modifier: MODEL1310110061#
notes: GENE_ASSOCIATION: (AA278423.1) or (48.1) or (50.1) SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: 2.7.1.1 Confidence Level: 0 AUTHORS: PMID:16906315,PMID:7061426,PMID:7150652,PMID:8717435 NOTES:
is: SBO:0000176
fast: false
type: Reaction
product: MODEL1310110061#
kinetic law: MODEL1310110061#
is version of: http://identifiers.org/ec-code/4.2.1.3
reactant: MODEL1310110061#
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110061#_98054534_0c72_4de4_9154_5b74eaf0ba56
is: SBO:0000252
boundary condition: true
has only substance units: false
name: _BE042354_1_m
initial amount: NaN
constant: false
initial concentration: NaN
type: Species
is encoded by: hsa:BE042354

metaR EX 3mob LPAREN e RPAREN
kinetic law: MODEL1310110061#
reactant: MODEL1310110061#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: Exchange of 3-methyl-2-oxobutanoate
type: Reaction

metaM xtsn c
initial concentration: 1.0
name: xanthosine
notes: FORMULA: C10H12N4O6 CHARGE: 0 INCHI: InChI=1S/C10H12N4O6/c15-1-3-5(16)6(17)9(20-3)14-2-11-4-7(14)12-10(19)13-8(4)18/h2-3,5-6,9,15-17H,1H2,(H2,12,13,18,19)/t3-,5-,6-,9-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00838 EHMN_ABBREVIATION: C01762
initial amount: NaN
is: CHEBI:18107
is: SBO:0000247
has only substance units: false
type: Species
is: HMDB00299
constant: false
boundary condition: false

metaM strdnccoa c
notes: FORMULA: C39H58N7O17P3S CHARGE: -4 INCHI: InChI=1/C39H62N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-30(48)67-23-22-41-29(47)20-21-42-37(51)34(50)39(2,3)25-60-66(57,58)63-65(55,56)59-24-28-33(62-64(52,53)54)32(49)38(61-28)46-27-45-31-35(40)43-26-44-36(31)46/h5-6,8-9,11-12,14-15,26-28,32-34,38,49-50H,4,7,10,13,16-25H2,1-3H3,(H,41,47)(H,42,51)(H,55,56)(H,57,58)(H2,40,43,44)(H2,52,53,54)/b6-5-,9-8-,12-11-,15-14-/t28-,32-,33?,34+,38-/m1/s1
boundary condition: false
is: HMDB06519
type: Species
constant: false
is: http://identifiers.org/pubchem.compound/47205473
initial amount: NaN
has only substance units: false
is: SBO:0000247
initial concentration: 1.0
is: C16163
name: stearidonyl coenzyme A

http://identifiers.org/biomodels.db/MODEL1310110061#_dc215be7_bc32_46a9_a774_f07fdfe56a97
has only substance units: false
initial amount: NaN
boundary condition: true
name: B3GALT5
is: SBO:0000252
initial concentration: NaN
constant: false
is encoded by: hsa:10317
type: Species

http://identifiers.org/biomodels.db/MODEL1310110061#_fda37b80_6f06_4afe_83ae_8540c68fa280
has only substance units: false
is encoded by: hsa:5728
initial amount: NaN
is: SBO:0000252
name: PTEN
is: F6KD01
initial concentration: NaN
constant: false
boundary condition: true
type: Species

metaR RE2625C
product: MODEL1310110061#
is: SBO:0000176
reactant: MODEL1310110061#
notes: GENE_ASSOCIATION: SUBSYSTEM: Bile acid synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:9660774 NOTES:
kinetic law: MODEL1310110061#
fast: false
reversible: true
name: RE2625
type: Reaction
is described by: ECO:0000000

metaM glcur e
name: D-glucuronate
is: CHEBI:15748
is: HMDB00127
type: Species
is: SBO:0000247
initial concentration: 1.0
notes: FORMULA: C6H9O7 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00182 EHMN_ABBREVIATION: C00191
constant: false
initial amount: NaN
boundary condition: false
has only substance units: false

metaR GMPtg
is: SBO:0000185
name: GMP transport (Golgi)
kinetic law: MODEL1310110061#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, golgi apparatus EC Number: 6.3.5.2 Confidence Level: 1 AUTHORS: PMID:7706277 NOTES:
reactant: MODEL1310110061#
fast: false
is described by: ECO:0000269
product: MODEL1310110061#
reversible: true

metaM CE5788 e
initial amount: NaN
boundary condition: false
name: kinetensin 1-7
initial concentration: 1.0
has only substance units: false
constant: false
is: SBO:0000247
notes: FORMULA: C41H67N15O9 CHARGE: 2 INCHI: InChI=1/C41H65N15O9/c1-4-22(2)32(42)37(62)51-23(3)33(58)52-27(8-5-15-48-40(43)44)34(59)53-28(9-6-16-49-41(45)46)35(60)54-29(19-25-20-47-21-50-25)38(63)56-17-7-10-31(56)36(61)55-30(39(64)65)18-24-11-13-26(57)14-12-24/h11-14,20-23,27-32,57H,4-10,15-19,42H2,1-3H3,(H,47,50)(H,51,62)(H,52,58)(H,53,59)(H,54,60)(H,55,61)(H,64,65)(H4,43,44,48)(H4,45,46,49)/p+2/t22-,23+,27-,28+,29-,30+,31-,32-/m1/s1 EHMN_ABBREVIATION: CE5788
is: CHEBI:27485
is: HMDB02710
type: Species

metaR SPHS1Pte
reactant: MODEL1310110061#
name: sphingosine-1-phosphate transport
kinetic law: MODEL1310110061#
reversible: true
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10751414 NOTES:unknown mechanism, however sphs1p is known to have intracellular and extracellular activity and signal transduction functions (PMID: 10751414). NJ
is: SBO:0000185
type: Reaction
is described by: ECO:0000000
product: MODEL1310110061#

metaM ru5p D c
notes: FORMULA: C5H9O8P CHARGE: -2 INCHI: InChI=1S/C5H11O8P/c6-1-3(7)5(9)4(8)2-13-14(10,11)12/h4-6,8-9H,1-2H2,(H2,10,11,12)/p-2/t4-,5+/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00188
is: HMDB00618
initial concentration: 1.0
constant: false
initial amount: NaN
has only substance units: false
is: CHEBI:58121
type: Species
is: SBO:0000247
boundary condition: false
name: D-ribulose 5-phosphate(2-)

metaM acgam l
notes: FORMULA: C8H15NO6 CHARGE: 0 INCHI: InChI=1S/C8H15NO6/c1-4(12)9-5(2-10)7(14)8(15)6(13)3-11/h2,5-8,11,13-15H,3H2,1H3,(H,9,12)/t5-,6+,7+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00138 EHMN_ABBREVIATION: C00140
type: Species
is: HMDB00215
is: SBO:0000247
initial concentration: 1.0
constant: false
has only substance units: false
name: N-acetyl-D-glucosamine
boundary condition: false
is: CHEBI:17411
initial amount: NaN

metaM adp m
is: HMDB01341
is: SBO:0000247
name: ADP
is: http://identifiers.org/pubchem.compound/3310
constant: false
has only substance units: false
boundary condition: false
initial amount: NaN
initial concentration: 1.0
is: C00008
is: CHEBI:456216
type: Species

metaM orn c
is: SBO:0000247
is: CHEBI:0
type: Species
constant: false
initial amount: NaN
has only substance units: false
notes: FORMULA: C5H13N2O2 CHARGE: 1
is: C01602
name: Ornithine
is: HMDB00214
boundary condition: false
initial concentration: 1.0

metaM docohexcoa m
initial amount: NaN
constant: false
has only substance units: false
name: 2,4,7,10,13,16-docosahexenoylcoa
is: SBO:0000247
type: Species
boundary condition: false
is: HMDB02288
notes: FORMULA: C43H62N7O17P3S CHARGE: -4
initial concentration: 1.0

metaM atp c
initial amount: NaN
type: Species
initial concentration: 1.0
has only substance units: false
is: HMDB00538
is: CHEBI:30616
is: C00002
is: SBO:0000247
boundary condition: false
name: ATP(4-)
constant: false

metaR MMSAD3m
name: methylmalonate-semialdehyde dehydrogenase (malonic semialdehyde), mitochondrial
is: SBO:0000176
reactant: MODEL1310110061#
type: Reaction
product: MODEL1310110061#
notes: GENE_ASSOCIATION: (4329.1) SUBSYSTEM: Propanoate metabolism EC Number: 1.2.1.27 Confidence Level: 4 AUTHORS: PMID:10947204,PMID:1527093,PMID:6418146 NOTES:also EC 1.2.1.18 - NCD
is version of: http://identifiers.org/ec-code/1.2.1.27
fast: false
is described by: ECO:0000269
reversible: false
modifier: MODEL1310110061#
kinetic law: MODEL1310110061#

metaM 3hpp m
notes: FORMULA: C3H5O3 CHARGE: -1 INCHI: InChI=1S/C3H6O3/c4-2-1-3(5)6/h4H,1-2H2,(H,5,6)/p-1 HEPATONET_1.0_ABBREVIATION: HC00625 EHMN_ABBREVIATION: C01013
is: SBO:0000247
initial amount: NaN
is: HMDB00700
constant: false
name: 3-hydroxypropionate
is: CHEBI:16510
boundary condition: false
initial concentration: 1.0
type: Species
has only substance units: false

metaM dctp c
constant: false
type: Species
is: HMDB00998
boundary condition: false
is: C00458
is: SBO:0000247
initial concentration: 1.0
notes: FORMULA: C9H12N3O13P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00367 EHMN_ABBREVIATION: C00458
name: dCTP
initial amount: NaN
is: CHEBI:16311
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110061#_8ff004a5_33c3_4a46_9a16_01757a538bf0
name: ALDH2
is: P05091
has only substance units: false
is: SBO:0000252
initial concentration: NaN
boundary condition: true
constant: false
type: Species
initial amount: NaN
is encoded by: hsa:217

metaR r0354
fast: false
kinetic law: MODEL1310110061#
reactant: MODEL1310110061#
is described by: ECO:0000000
name: Glycolysis / Glyconeogenesis EC:2.7.1.1
is version of: http://identifiers.org/ec-code/6.2.1.3
is: SBO:0000176
notes: GENE_ASSOCIATION: (AA788780.1) or (AA977580.1) or (2180.1) or (2181.1) or (2182.1) or (51703.1) or (23305.1) or (AI694761.1) or (AI915649.1) or (AL525798.1) or (AV727634.1) or (728637.1) or (LOC728997.1) or (11001.1) SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: 2.7.1.1 Confidence Level: 0 AUTHORS: PMID:16906315,PMID:7061426,PMID:7150652,PMID:8717435 NOTES:
type: Reaction
reversible: false
modifier: MODEL1310110061#
product: MODEL1310110061#

metaR r2338
is: SBO:0000185
reversible: true
type: Reaction
is described by: ECO:0000000
name: Major Facilitator(MFS) TCDB:2.A.1.19.1
kinetic law: MODEL1310110061#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12883891 NOTES:
product: MODEL1310110061#
reactant: MODEL1310110061#
fast: false

metaM pan4p m
is: CHEBI:47942
is: SBO:0000247
initial concentration: 1.0
boundary condition: false
initial amount: NaN
has only substance units: false
notes: FORMULA: C11H21N2O7PS CHARGE: -2 INCHI: InChI=1S/C11H23N2O7PS/c1-11(2,7-20-21(17,18)19)9(15)10(16)13-4-3-8(14)12-5-6-22/h9,15,22H,3-7H2,1-2H3,(H,12,14)(H,13,16)(H2,17,18,19)/p-2 HEPATONET_1.0_ABBREVIATION: HC00681 EHMN_ABBREVIATION: C01134
is: HMDB01416
name: pantetheine 4'-phosphate(2-)
type: Species
constant: false

metaR BDHm
modifier: MODEL1310110061#
type: Reaction
kinetic law: MODEL1310110061#
reactant: MODEL1310110061#
is: SBO:0000176
product: MODEL1310110061#
is version of: http://identifiers.org/ec-code/1.1.1.30
fast: false
reversible: true
name: (R)-3-Hydroxybutanoate:NAD+ oxidoreductase
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (622.2) or (622.3) or (622.1) SUBSYSTEM: Butanoate metabolism EC Number: 1.1.1.30 Confidence Level: 4 AUTHORS: PMID:1639787,PMID:8679568 NOTES:IT

metaM dcsptn1coa c
initial amount: NaN
notes: FORMULA: C43H64N7O17P3S CHARGE: -4 INCHI: InChI=1/C43H68N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-34(52)71-27-26-45-33(51)24-25-46-41(55)38(54)43(2,3)29-64-70(61,62)67-69(59,60)63-28-32-37(66-68(56,57)58)36(53)42(65-32)50-31-49-35-39(44)47-30-48-40(35)50/h8-9,11-12,14-15,17-18,20-21,30-32,36-38,42,53-54H,4-7,10,13,16,19,22-29H2,1-3H3,(H,45,51)(H,46,55)(H,59,60)(H,61,62)(H2,44,47,48)(H2,56,57,58)/b9-8-,12-11-,15-14-,18-17-,21-20-/t32-,36-,37?,38+,42-/m1/s1
name: docosa-4,7,10,13,16-pentaenoyl coenzyme A
has only substance units: false
type: Species
boundary condition: false
constant: false
initial concentration: 1.0
is: HMDB06513
is: http://identifiers.org/pubchem.compound/47205483
is: C16173
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110061#_34eaa725_aebb_4975_bc48_6e4be5db1f6d
name: GCH1
is: Q8IZH9
initial concentration: NaN
has only substance units: false
is: SBO:0000252
is encoded by: hsa:2643
type: Species
constant: false
boundary condition: true
initial amount: NaN

metaR FOLt2le
fast: false
product: MODEL1310110061#
reversible: true
name: folate transport via anion exchange
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
type: Reaction
reactant: MODEL1310110061#
kinetic law: MODEL1310110061#
is described by: ECO:0000134

metaR DCSPTN1CRNt
type: Reaction
reversible: false
kinetic law: MODEL1310110061#
fast: false
product: MODEL1310110061#
modifier: MODEL1310110061#
notes: GENE_ASSOCIATION: (788.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: NOTES:NJ
is: SBO:0000185
reactant: MODEL1310110061#
is described by: ECO:0000269
name: transport into the mitochondria (carnitine)

http://identifiers.org/biomodels.db/MODEL1310110061#_c8aa4c0e_b8a9_47e5_9b2a_610bacc59b04
is: GO:0005739
is: SBO:0000290
constant: false
size: 1.0
spatial dimensions: 3.0
name: mitochondrion
type: Compartment

metaR CYSTGL
is version of: http://identifiers.org/ec-code/4.4.1.1
modifier: MODEL1310110061#
reversible: false
type: Reaction
product: MODEL1310110061#
is described by: ECO:0000269
name: cystathionine g-lyase
reactant: MODEL1310110061#
notes: GENE_ASSOCIATION: (1491.1) or (1491.2) SUBSYSTEM: Methionine and cysteine metabolism EC Number: 4.4.1.1 Confidence Level: 4 AUTHORS: PMID:10727430,PMID:15189131 NOTES:NCD
fast: false
kinetic law: MODEL1310110061#
is: SBO:0000176

metaR RE2349C
modifier: MODEL1310110061#
notes: GENE_ASSOCIATION: (883.1) SUBSYSTEM: Tryptophan metabolism EC Number: 2.6.1.7 Confidence Level: 0 AUTHORS: PMID:10559215,PMID:8908429 NOTES:IT - removed H[c] on right hand side even though no charged formula for Kegg compound but same as reaction RE1233C
product: MODEL1310110061#
reversible: true
reactant: MODEL1310110061#
fast: false
type: Reaction
is: SBO:0000176
kinetic law: MODEL1310110061#
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/2.6.1.64
name: RE2349

metaR r0556
kinetic law: MODEL1310110061#
is: SBO:0000176
product: MODEL1310110061#
notes: GENE_ASSOCIATION: (AF116616.1) or (PRO1933.1) or (6319.1) or (79966.1) SUBSYSTEM: Unassigned EC Number: 2.3.1.61 Confidence Level: 0 AUTHORS: PMID:8076640,PMID:9620315 NOTES:
type: Reaction
reversible: true
reactant: MODEL1310110061#
is version of: http://identifiers.org/ec-code/1.14.19.1
is described by: ECO:0000000
name: succinyl-CoA:enzyme N6-(dihydrolipoyl)lysine S-succinyltransferase Citrate cycle (TCA cycle) EC:2.3.1.61
modifier: MODEL1310110061#
fast: false

metaM adp n
is: SBO:0000247
notes: FORMULA: C10H12N5O10P2 CHARGE: -3 INCHI: InChI=1S/C10H15N5O10P2/c11-8-5-9(13-2-12-8)15(3-14-5)10-7(17)6(16)4(24-10)1-23-27(21,22)25-26(18,19)20/h2-4,6-7,10,16-17H,1H2,(H,21,22)(H2,11,12,13)(H2,18,19,20)/p-3/t4-,6-,7-,10-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00018 EHMN_ABBREVIATION: C00008
initial concentration: 1.0
constant: false
has only substance units: false
is: HMDB01341
initial amount: NaN
name: ADP(3-)
is: CHEBI:456216
type: Species
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110061#_8d5b3644_8fd3_40bf_985f_21f13c8b5727
initial amount: NaN
is: SBO:0000252
name: ACOT6
is encoded by: hsa:641372
type: Species
boundary condition: true
has only substance units: false
initial concentration: NaN
constant: false
is: Q3I5F7

metaR FAOXC226C227m
kinetic law: MODEL1310110061#
product: MODEL1310110061#
reactant: MODEL1310110061#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C22:6-->C22:7)m
type: Reaction

metaR r0022
name: glutathione:NAD+ oxidoreductase Glutamate metabolism EC:1.8.1.7
kinetic law: MODEL1310110061#
is: SBO:0000176
notes: GENE_ASSOCIATION: (AA532636.1) or (2936.1) SUBSYSTEM: Glutathione metabolism EC Number: 1.8.1.7 Confidence Level: 0 AUTHORS: PMID:10781871,PMID:12821209,PMID:237878,PMID:31912,PMID:4380255,PMID:8981046,PMID:9621574 NOTES:
type: Reaction
fast: false
reversible: true
is version of: http://identifiers.org/ec-code/1.8.1.7
modifier: MODEL1310110061#
is described by: ECO:0000000
reactant: MODEL1310110061#
product: MODEL1310110061#

metaR BILDGLCURt
reactant: MODEL1310110061#
product: MODEL1310110061#
is described by: ECO:0000269
reversible: true
name: bilirubin beta-diglucuronide transport via bicarbonate countertransport
modifier: MODEL1310110061#
fast: false
is: SBO:0000185
type: Reaction
notes: GENE_ASSOCIATION: (10599.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10358072,PMID:12507753,PMID:9334206 NOTES:NJ
kinetic law: MODEL1310110061#

http://identifiers.org/biomodels.db/MODEL1310110061#_fe688052_cde1_47c7_b1a2_b8dad3211b66
boundary condition: true
is: P21589
is: SBO:0000252
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:4907
constant: false
type: Species
has only substance units: false
name: NT5E

metaM ksii core2 deg9 l
type: Species
constant: false
notes: FORMULA: C30H50N3O20X CHARGE: 0
is: HMDB00143
is: CHEBI:12936
has only substance units: false
initial concentration: 1.0
is: SBO:0000247
name: keratan sulfate II (core 2-linked), degradation product 9
boundary condition: false
initial amount: NaN

metaR r1599
type: Reaction
is described by: ECO:0000000
reversible: true
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reactant: MODEL1310110061#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
kinetic law: MODEL1310110061#
product: MODEL1310110061#
is: SBO:0000185

metaM 4abut m
notes: FORMULA: C4H9NO2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00284 EHMN_ABBREVIATION: C00334
boundary condition: false
constant: false
initial amount: NaN
name: 4-Aminobutanoate
is: CHEBI:16865
type: Species
is: HMDB00112
is: C00334
is: SBO:0000247
initial concentration: 1.0
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110061#_11c99d6f_0b9b_43c7_b126_49bb4d818a9a
has only substance units: false
is: B3KQH0
constant: false
initial concentration: NaN
name: SLC35C1
type: Species
boundary condition: true
initial amount: NaN
is: SBO:0000252
is encoded by: hsa:55343

metaR CMPACNAtg
is: SBO:0000185
name: CMP-Sia Golgi transport via CMP antiport
notes: GENE_ASSOCIATION: (10559.1) SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 4 AUTHORS: PMID:12759756,PMID:9010752,PMID:9644260 NOTES:NCD
reactant: MODEL1310110061#
fast: false
reversible: true
type: Reaction
is described by: ECO:0000269
modifier: MODEL1310110061#
kinetic law: MODEL1310110061#
product: MODEL1310110061#

http://identifiers.org/biomodels.db/MODEL1310110061#_47a89916_a169_43f1_bbb2_4da013287d56
is encoded by: hsa:223
name: ALDH9A1
is: P49189
initial concentration: NaN
initial amount: NaN
has only substance units: false
is: SBO:0000252
type: Species
constant: false
boundary condition: true

metaR PROSTGH2t
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:12827517,PMID:12883891,PMID:9187257 NOTES:
reactant: MODEL1310110061#
kinetic law: MODEL1310110061#
reversible: true
is: SBO:0000185
is described by: ECO:0000269
fast: false
type: Reaction
name: Prostaglandin H2 transport
product: MODEL1310110061#

http://identifiers.org/biomodels.db/MODEL1310110061#_1d5ef4af_d489_430e_9851_0334a9dc8f37
is encoded by: hsa:56953
constant: false
is: Q9NPB1
initial concentration: NaN
has only substance units: false
name: NT5M
initial amount: NaN
type: Species
is: SBO:0000252
boundary condition: true

metaR r0555
product: MODEL1310110061#
is described by: ECO:0000000
reactant: MODEL1310110061#
kinetic law: MODEL1310110061#
modifier: MODEL1310110061#
reversible: false
notes: GENE_ASSOCIATION: (6576.1) SUBSYSTEM: Unassigned EC Number: 2.3.1.12 Confidence Level: 0 AUTHORS: PMID:12108679,PMID:14741190 NOTES:
is: SBO:0000176
fast: false
name: acetyl-CoA:enzyme N6-(dihydrolipoyl)lysine S-acetyltransferase Glycolysis / Gluconeogenesis / Alanine and aspartate metabolism / Pyruvate metabolism EC:2.3.1.12
type: Reaction

metaR FAOXC14C12m
kinetic law: MODEL1310110061#
product: MODEL1310110061#
reactant: MODEL1310110061#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C14-->C12)m
type: Reaction

metaR r0021
is: SBO:0000176
type: Reaction
reversible: true
product: MODEL1310110061#
name: glutathione:NAD+ oxidoreductase Glutamate metabolism EC:1.8.1.7
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (AV717590.1) or (953.1) or (954.1) or (956.1) or (377841.1) SUBSYSTEM: Glutathione metabolism EC Number: 1.8.1.7 Confidence Level: 0 AUTHORS: PMID:10781871,PMID:12821209,PMID:237878,PMID:31912,PMID:4380255,PMID:8981046,PMID:9621574 NOTES:IT - fixed proton
reactant: MODEL1310110061#
fast: false
is version of: http://identifiers.org/ec-code/3.6.1.5
modifier: MODEL1310110061#
kinetic law: MODEL1310110061#

metaM HC02208 e
initial amount: NaN
notes: FORMULA: C20H33O5 CHARGE: -1 INCHI: InChI=1S/C20H34O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h12-13,15-18,21-22H,2-11,14H2,1H3,(H,24,25)/b13-12+/t15-,16+,17+,18-/m0/s1
has only substance units: false
type: Species
is: SBO:0000247
initial concentration: 1.0
is: CHEBI:27696
constant: false
name: prostaglandin-d1
boundary condition: false

metaR MI1P Dtn
reactant: MODEL1310110061#
is described by: ECO:0000000
is: SBO:0000185
kinetic law: MODEL1310110061#
reversible: true
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 1 AUTHORS: NOTES:
product: MODEL1310110061#
name: inositol 1-phosphate nuclear transport (diffusion)
fast: false

metaM CE5121 m
is: SBO:0000247
constant: false
initial concentration: 1.0
initial amount: NaN
boundary condition: false
notes: FORMULA: C31H48N7O17P3S CHARGE: -4 INCHI: InChI=1/C31H52N7O17P3S/c1-4-5-6-7-8-9-10-11-22(40)59-15-14-33-21(39)12-13-34-29(43)26(42)31(2,3)17-52-58(49,50)55-57(47,48)51-16-20-25(54-56(44,45)46)24(41)30(53-20)38-19-37-23-27(32)35-18-36-28(23)38/h9-10,18-20,24-26,30,41-42H,4-8,11-17H2,1-3H3,(H,33,39)(H,34,43)(H,47,48)(H,49,50)(H2,32,35,36)(H2,44,45,46)/p-4/b10-9+/t20-,24+,25+,26u,30-/m0/s1 EHMN_ABBREVIATION: CE5121
is: CHEBI:57449
type: Species
has only substance units: false
name: trans-3-decenoyl-CoA

metaR DOPACHRMISO
notes: GENE_ASSOCIATION: (7299.1) SUBSYSTEM: Tyrosine metabolism EC Number: 1.14.18.1 Confidence Level: 4 AUTHORS: PMID:5294951 NOTES:SAB
product: MODEL1310110061#
modifier: MODEL1310110061#
kinetic law: MODEL1310110061#
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/1.14.18.1
type: Reaction
name: L-dopachrome isomerase 1
is: SBO:0000176
fast: false
reactant: MODEL1310110061#
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110061#_c9d6b592_3472_4805_ad0e_50a36567dcba
constant: false
name: DHCR24
is: Q15392
initial concentration: NaN
has only substance units: false
boundary condition: true
initial amount: NaN
is: SBO:0000252
is encoded by: hsa:1718
type: Species

metaR r2525
type: Reaction
reactant: MODEL1310110061#
fast: false
name: Major Facilitator(MFS) TCDB:2.A.1.44.1
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:10049700,PMID:10574970,PMID:11389679,PMID:11557028,PMID:11564694,PMID:12824232,PMID:12930836,PMID:14574404,PMID:16288981,PMID:911815 NOTES:
is described by: ECO:0000000
product: MODEL1310110061#
reversible: true
is: SBO:0000185
kinetic law: MODEL1310110061#

metaR r1598
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is described by: ECO:0000000
is: SBO:0000185
kinetic law: MODEL1310110061#
reactant: MODEL1310110061#
product: MODEL1310110061#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
fast: false
reversible: true
type: Reaction

metaM val L m
has only substance units: false
is: SBO:0000247
boundary condition: false
is: HMDB00883
is: CHEBI:16414
initial amount: NaN
initial concentration: 1.0
type: Species
notes: FORMULA: C5H11NO2 CHARGE: 0 INCHI: InChI=1S/C5H11NO2/c1-3(2)4(6)5(7)8/h3-4H,6H2,1-2H3,(H,7,8)/t4-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00174
constant: false
name: L-valine

metaM 4hpro LT m
notes: FORMULA: C5H9NO3 CHARGE: 0 INCHI: InChI=1S/C5H9NO3/c7-3-1-4(5(8)9)6-2-3/h3-4,6-7H,1-2H2,(H,8,9)/t3-,4+/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00690
initial amount: NaN
has only substance units: false
boundary condition: false
is: SBO:0000247
is: HMDB00725
initial concentration: 1.0
is: CHEBI:18095
name: trans-4-hydroxy-L-proline
type: Species
constant: false

metaR PROD2
notes: GENE_ASSOCIATION: (58510.1) SUBSYSTEM: Arginine and Proline Metabolism EC Number: 1.5.99.8 Confidence Level: 2 AUTHORS: PMID:10192398 NOTES:JLR
is described by: ECO:0000254
reactant: MODEL1310110061#
is version of: http://identifiers.org/ec-code/1.5.99.8
modifier: MODEL1310110061#
fast: false
is: SBO:0000176
kinetic law: MODEL1310110061#
reversible: false
type: Reaction
name: Proline dehydrogenase
product: MODEL1310110061#

http://identifiers.org/biomodels.db/MODEL1310110061#_45345f89_4452_49d7_bb71_1f74df19db8c
is encoded by: hsa:2110
boundary condition: true
name: ETFDH
is: SBO:0000252
initial concentration: NaN
has only substance units: false
initial amount: NaN
type: Species
constant: false
is: Q16134

http://identifiers.org/biomodels.db/MODEL1310110061#_6783c3e3_7aa5_4961_b453_d5fb0903e64f
is: O00459
initial amount: NaN
is: SBO:0000252
constant: false
is encoded by: hsa:5296
boundary condition: true
initial concentration: NaN
type: Species
has only substance units: false
name: PIK3R2

http://identifiers.org/biomodels.db/MODEL1310110061#_87458d4a_6c38_4bf7_83cf_0626c0f2051f
name: ENTPD8
initial concentration: NaN
boundary condition: true
constant: false
is: Q5MY95
initial amount: NaN
type: Species
is: SBO:0000252
is encoded by: hsa:377841
has only substance units: false

metaM CE5119 m
initial concentration: 1.0
has only substance units: false
initial amount: NaN
boundary condition: false
notes: FORMULA: C35H54N7O17P3S CHARGE: -4 INCHI: InChI=1/C35H58N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-26(44)63-19-18-37-25(43)16-17-38-33(47)30(46)35(2,3)21-56-62(53,54)59-61(51,52)55-20-24-29(58-60(48,49)50)28(45)34(57-24)42-23-41-27-31(36)39-22-40-32(27)42/h8-9,13-14,22-24,28-30,34,45-46H,4-7,10-12,15-21H2,1-3H3,(H,37,43)(H,38,47)(H,51,52)(H,53,54)(H2,36,39,40)(H2,48,49,50)/p-4/b9-8-,14-13+/t24-,28+,29+,30u,34-/m0/s1 EHMN_ABBREVIATION: CE5119
type: Species
name: trans-3-cis-8-tetradecadienoyl-CoA
is: CHEBI:57923
is: SBO:0000247
constant: false

metaR ALAGLYexR
notes: GENE_ASSOCIATION: (56301.1) and (6520.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10734121,PMID:10863037,PMID:14770310 NOTES:
is described by: ECO:0000304
is: SBO:0000185
fast: false
reversible: true
product: MODEL1310110061#
reactant: MODEL1310110061#
type: Reaction
modifier: MODEL1310110061#
name: L-alanine/glycine reversible exchange
kinetic law: MODEL1310110061#

metaM 34dhoxmand c
boundary condition: false
notes: FORMULA: C8H7O5 CHARGE: -1 INCHI: InChI=1S/C8H8O5/c9-5-2-1-4(3-6(5)10)7(11)8(12)13/h1-3,7,9-11H,(H,12,13) HEPATONET_1.0_ABBREVIATION: HC01517 EHMN_ABBREVIATION: C05580
name: 3,4-Dihydroxymandelate
type: Species
is: HMDB01866
initial amount: NaN
has only substance units: false
is: SBO:0000247
initial concentration: 1.0
constant: false
is: CHEBI:27637

http://identifiers.org/biomodels.db/MODEL1310110061#_9f653369_d61a_4251_addb_15f18a073c34
type: Species
is: SBO:0000252
is: C9JC79
initial concentration: NaN
is encoded by: hsa:6342
name: SCP2
constant: false
boundary condition: true
has only substance units: false
initial amount: NaN

metaR r2335
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
type: Reaction
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
is described by: ECO:0000000
reversible: true
product: MODEL1310110061#
fast: false
is: SBO:0000185
reactant: MODEL1310110061#
kinetic law: MODEL1310110061#

metaR RE1532M
is described by: ECO:0000000
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.3.1.16
is version of: http://identifiers.org/ec-code/4.2.1.17
kinetic law: MODEL1310110061#
type: Reaction
name: RE1532
fast: false
modifier: MODEL1310110061#
reactant: MODEL1310110061#
reversible: true
notes: GENE_ASSOCIATION: (10449.1) or (3032.1) or (3030.1) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.16 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:7775433,PMID:7923814,PMID:9568246,PMID:9920399 NOTES:
product: MODEL1310110061#

metaR EX strdnc LPAREN e RPAREN
kinetic law: MODEL1310110061#
reactant: MODEL1310110061#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: stearidonic acid exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110061#_ebb234de_9435_4a06_ac79_ac230a2a7ac1
initial amount: NaN
is: SBO:0000252
initial concentration: NaN
constant: false
name: SLC5A5
is: Q92911
has only substance units: false
is encoded by: hsa:6528
type: Species
boundary condition: true

metaM 7dhf e
initial concentration: 1.0
has only substance units: false
boundary condition: false
is: SBO:0000247
is: HMDB06559
notes: FORMULA: C49H55N13O24 CHARGE: -8 INCHI: InChI=1/C54H68N14O27/c55-24(5-12-31(69)70)39(83)52(49(92)93,40(84)25(56)6-13-32(71)72)53(41(85)26(57)7-14-33(73)74,42(86)27(58)8-15-34(75)76)54(43(87)28(59)9-16-35(77)78,50(94)95-48(91)30(61)11-18-37(81)82)68(47(90)29(60)10-17-36(79)80)46(89)21-1-3-22(4-2-21)63-19-23-20-64-44-38(65-23)45(88)67-51(62)66-44/h1-4,20,24-30,63H,5-19,55-61H2,(H,69,70)(H,71,72)(H,73,74)(H,75,76)(H,77,78)(H,79,80)(H,81,82)(H,92,93)(H3,62,64,66,67,88)/t24-,25-,26-,27-,28-,29-,30-,54?/m0/s1
name: heptaglutamyl folate (DHF)
initial amount: NaN
constant: false
type: Species

metaR RTOTAL3t
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:14598172 NOTES:
fast: false
is described by: ECO:0000000
type: Reaction
product: MODEL1310110061#
kinetic law: MODEL1310110061#
reversible: true
is: SBO:0000185
reactant: MODEL1310110061#
name: RTOTAL3 transport

metaR 3HBCOAHLm
product: MODEL1310110061#
type: Reaction
name: 3-hydroxyisobutyryl-CoA hydrolase, mitochondrial
is: SBO:0000176
reversible: false
kinetic law: MODEL1310110061#
notes: GENE_ASSOCIATION: SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 3.1.2.4 Confidence Level: 2 AUTHORS: PMID:8824301 NOTES:MM
reactant: MODEL1310110061#
fast: false
is described by: ECO:0000000

metaR r1597
reversible: true
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
type: Reaction
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
fast: false
reactant: MODEL1310110061#
product: MODEL1310110061#
kinetic law: MODEL1310110061#
is: SBO:0000185

metaR r2526
is: SBO:0000185
reactant: MODEL1310110061#
is described by: ECO:0000000
name: Major Facilitator(MFS) TCDB:2.A.1.44.1
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:10049700,PMID:10574970,PMID:11389679,PMID:11557028,PMID:11564694,PMID:12824232,PMID:12930836,PMID:14574404,PMID:16288981,PMID:911815 NOTES:
product: MODEL1310110061#
reversible: true
kinetic law: MODEL1310110061#
fast: false
type: Reaction

metaM sbt D e
boundary condition: false
is: SBO:0000247
constant: false
type: Species
name: D-glucitol
is: HMDB00247
initial amount: NaN
has only substance units: false
initial concentration: 1.0
notes: FORMULA: C6H14O6 CHARGE: 0 INCHI: InChI=1S/C6H14O6/c7-1-3(9)5(11)6(12)4(10)2-8/h3-12H,1-2H2/t3-,4+,5-,6-/m1/s1

metaR r0627
name: Galactosylglycerol galactohydrolase Galactose metabolism EC:3.2.1.22 EC:3.2.1.23
kinetic law: MODEL1310110061#
product: MODEL1310110061#
reactant: MODEL1310110061#
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 3.2.1.23 Confidence Level: 0 AUTHORS: PMID:3569296 NOTES:
type: Reaction
is: SBO:0000176
reversible: true
fast: false
is described by: ECO:0000000

metaR r0779
modifier: MODEL1310110061#
notes: GENE_ASSOCIATION: (1892.1) or (1962.1) or (3030.1) SUBSYSTEM: Unassigned EC Number: 3.1.2.4 Confidence Level: 0 AUTHORS: PMID:11580916,PMID:8188708 NOTES:
is version of: http://identifiers.org/ec-code/4.2.1.17
product: MODEL1310110061#
reversible: false
kinetic law: MODEL1310110061#
reactant: MODEL1310110061#
name: 3-Hydroxy-2-methylpropanoyl-CoA hydrolase EC:3.1.2.4
is described by: ECO:0000000
fast: false
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.1.1.35
type: Reaction

metaR FACOAL180i
fast: false
reactant: MODEL1310110061#
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (22305.2) or (2181.2) or (51703.1) or (2181.1) or (2180.1) or (22305.1) SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 4 AUTHORS: NOTES:TV catalyzed by acyl-CoA synthetases
type: Reaction
modifier: MODEL1310110061#
is version of: http://identifiers.org/ec-code/6.2.1.3
product: MODEL1310110061#
is: SBO:0000176
reversible: false
name: C180 fatty acid activation
kinetic law: MODEL1310110061#

metaR GLNS
is: SBO:0000176
product: MODEL1310110061#
notes: GENE_ASSOCIATION: (2752.1) or (51557.1) SUBSYSTEM: Glutamate metabolism EC Number: Confidence Level: 2 AUTHORS: NOTES:
type: Reaction
modifier: MODEL1310110061#
is described by: ECO:0000254
name: glutamine synthetase
is version of: http://identifiers.org/ec-code/4.1.1.15
reversible: false
fast: false
kinetic law: MODEL1310110061#
reactant: MODEL1310110061#

metaR THRALANaEx
name: L-alanine/L-threonine Na-dependent exchange (Thr-L in)
reversible: false
product: MODEL1310110061#
is described by: ECO:0000269
type: Reaction
is: SBO:0000185
fast: false
reactant: MODEL1310110061#
kinetic law: MODEL1310110061#
notes: GENE_ASSOCIATION: (6509.1) or (6510.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14530974 NOTES:SAB see Kanai and Hediger 2004 (2003), PMID 14530974
modifier: MODEL1310110061#

metaR GTHRDtr
is: SBO:0000185
type: Reaction
kinetic law: MODEL1310110061#
reversible: true
name: glutathione transport via diffusion
reactant: MODEL1310110061#
product: MODEL1310110061#
is described by: ECO:0000000
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: NOTES:unknown mechanism - NJ

metaR r0553
product: MODEL1310110061#
type: Reaction
name: p-Cumic alcohol:NADP+ oxidoreductase Glycine, serine and threonine metabolism EC:1.2.1.8
is described by: ECO:0000000
reactant: MODEL1310110061#
reversible: true
kinetic law: MODEL1310110061#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Glycine, serine, alanine and threonine metabolism EC Number: 1.2.1.8 Confidence Level: 0 AUTHORS: PMID:10505788,PMID:7646513 NOTES:
is: SBO:0000176

metaM dhap x
constant: false
initial concentration: 1.0
is: SBO:0000247
is: C00111
has only substance units: false
is: http://identifiers.org/pubchem.compound/3411
is: CHEBI:57642
boundary condition: false
initial amount: NaN
name: Dihydroxyacetone phosphate
is: HMDB01473
type: Species

metaR r2334
reactant: MODEL1310110061#
kinetic law: MODEL1310110061#
type: Reaction
is described by: ECO:0000000
fast: false
is: SBO:0000185
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
product: MODEL1310110061#
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2

http://identifiers.org/biomodels.db/MODEL1310110061#_be056969_0f77_46b8_b8d8_76f89aa17002
initial amount: NaN
is encoded by: hsa:3030
type: Species
boundary condition: true
name: HADHA
is: E9KL44
constant: false
has only substance units: false
initial concentration: NaN
is: SBO:0000252

metaM HC02208 c
notes: FORMULA: C20H33O5 CHARGE: -1 INCHI: InChI=1S/C20H34O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h12-13,15-18,21-22H,2-11,14H2,1H3,(H,24,25)/b13-12+/t15-,16+,17+,18-/m0/s1
has only substance units: false
initial amount: NaN
initial concentration: 1.0
type: Species
is: CHEBI:27696
is: SBO:0000247
constant: false
name: prostaglandin-d1
boundary condition: false

metaR HSD17B2r
modifier: MODEL1310110061#
is: SBO:0000176
notes: GENE_ASSOCIATION: (3294.1) SUBSYSTEM: Steroid metabolism EC Number: 1.1.1.62 Confidence Level: 4 AUTHORS: PMID:8099587 NOTES:microsomal NAD as cofactor HSD type 2 recheck/confirm comparmentalization - type 1: cytosol, types 2,3: microsomes NJ
product: MODEL1310110061#
type: Reaction
reactant: MODEL1310110061#
is version of: http://identifiers.org/ec-code/1.1.1.62
is described by: ECO:0000269
kinetic law: MODEL1310110061#
fast: false
name: 17-beta-hydroxysteroid dehydrogenase
reversible: false

metaR PGS
name: Prostaglandin G/H synthase
product: MODEL1310110061#
type: Reaction
kinetic law: MODEL1310110061#
notes: GENE_ASSOCIATION: (5743.1) or (5742.1) SUBSYSTEM: Eicosanoid metabolism EC Number: 1.14.99.1 Confidence Level: 4 AUTHORS: PMID:14511332,PMID:1907252 NOTES:NJ
reactant: MODEL1310110061#
is: SBO:0000176
is described by: ECO:0000269
fast: false
is version of: http://identifiers.org/ec-code/1.14.99.1
reversible: false
modifier: MODEL1310110061#

metaR FAEL205
reactant: MODEL1310110061#
modifier: MODEL1310110061#
product: MODEL1310110061#
kinetic law: MODEL1310110061#
name: fatty-acyl-CoA elongation (n-C20:5CoA)
type: Reaction
reversible: false
fast: false
notes: GENE_ASSOCIATION: (6785.1) SUBSYSTEM: Fatty acid synthesis EC Number: 2.3.1.86 Confidence Level: 4 AUTHORS: PMID:11138005,PMID:15189125 NOTES:fatty acid elongation step NJ
is described by: ECO:0000000
is: SBO:0000176

metaR RE1573M
kinetic law: MODEL1310110061#
name: RE1573
product: MODEL1310110061#
modifier: MODEL1310110061#
notes: GENE_ASSOCIATION: (1632.1) or (10455.1) or (1962.1) SUBSYSTEM: Fatty acid oxidation EC Number: 5.3.3.8 Confidence Level: 0 AUTHORS: PMID:10407780 NOTES:
reversible: true
fast: false
is version of: http://identifiers.org/ec-code/1.1.1.35
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/5.3.3.8
type: Reaction
is: SBO:0000176
reactant: MODEL1310110061#

http://identifiers.org/biomodels.db/MODEL1310110061#_302c7dac_f9bb_4b44_a3d2_51e98b9e6290
constant: false
initial amount: NaN
boundary condition: true
name: SUOX
is encoded by: hsa:6821
is: P51687
initial concentration: NaN
type: Species
is: SBO:0000252
has only substance units: false

metaR DM dctp m
kinetic law: MODEL1310110061#
reactant: MODEL1310110061#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 0 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: false
name: dCTP demand
type: Reaction

metaR r1596
type: Reaction
kinetic law: MODEL1310110061#
reversible: true
is described by: ECO:0000000
fast: false
is: SBO:0000185
reactant: MODEL1310110061#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
product: MODEL1310110061#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1

metaR r2129
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
reversible: true
kinetic law: MODEL1310110061#
modifier: MODEL1310110061#
product: MODEL1310110061#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
is described by: ECO:0000000
fast: false
reactant: MODEL1310110061#
is: SBO:0000185
type: Reaction

metaM galacglcgalgluside hs g
name: Lc4Cer
boundary condition: false
constant: false
is: CHEBI:17103
initial concentration: 1.0
is: SBO:0000247
type: Species
has only substance units: false
initial amount: NaN
notes: FORMULA: C44H79N2O22FULLRCO CHARGE: 0

metaR CHSTEROLtrc
reversible: true
fast: false
name: transport of cholesterol into the cytosol
kinetic law: MODEL1310110061#
is: SBO:0000185
type: Reaction
is described by: ECO:0000134
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: PMID: 11229876 NOTES:newly synthesized cholesterol may either be incorporated into membrane or transported out of enterocytes.
product: MODEL1310110061#
reactant: MODEL1310110061#

metaM ins e
initial amount: NaN
initial concentration: 1.0
is: HMDB00195
is: SBO:0000247
boundary condition: false
is: CHEBI:17596
is: C00294
constant: false
name: Inosine
has only substance units: false
type: Species
notes: FORMULA: C10H12N4O5 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00255 EHMN_ABBREVIATION: C00294

metaR TAUPAT1c
kinetic law: MODEL1310110061#
product: MODEL1310110061#
reactant: MODEL1310110061#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of taurine into the intestinal cells by PAT1
type: Reaction

metaR PIPLCn
modifier: MODEL1310110061#
notes: GENE_ASSOCIATION: (23236.2) or (23236.1) SUBSYSTEM: Inositol phosphate metabolism EC Number: 3.1.4.3 Confidence Level: 4 AUTHORS: PMID:10760467,PMID:11118617,PMID:12213492 NOTES:NCD
product: MODEL1310110061#
is described by: ECO:0000000
type: Reaction
reversible: false
fast: false
kinetic law: MODEL1310110061#
is version of: http://identifiers.org/ec-code/3.1.4.11
is: SBO:0000176
name: phosphatidylinositol phospholipase C, nucleus
reactant: MODEL1310110061#

metaM 4abut n
boundary condition: false
is: HMDB00112
is: C00334
notes: FORMULA: C4H9NO2 CHARGE: 0
name: 4-Aminobutanoate
has only substance units: false
constant: false
initial amount: NaN
initial concentration: 1.0
type: Species
is: SBO:0000247

metaM cytd c
is: CHEBI:17562
initial amount: NaN
constant: false
name: Cytidine
notes: FORMULA: C9H13N3O5 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00381 EHMN_ABBREVIATION: C00475
initial concentration: 1.0
type: Species
is: SBO:0000247
is: C00475
is: HMDB00089
boundary condition: false
has only substance units: false

metaR EX maltttr LPAREN e RPAREN
kinetic law: MODEL1310110061#
reactant: MODEL1310110061#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Maltotetraose exchange
type: Reaction

metaR PNTEH
is described by: ECO:0000269
reactant: MODEL1310110061#
is version of: http://identifiers.org/ec-code/3.5.1.92
type: Reaction
modifier: MODEL1310110061#
kinetic law: MODEL1310110061#
notes: GENE_ASSOCIATION: (8876.1) and (8875.2) and (55350.3) or (8876.1) and (8875.2) and (55350.2) or (8876.1) and (8875.1) and (55350.1) or (8876.1) and (55350.2) and (8875.1) or (8875.2) and (8876.1) and (55350.1) or (8876.1) and (55350.3) and (8875.1) SUBSYSTEM: CoA catabolism EC Number: Confidence Level: 4 AUTHORS: PMID:10567687,PMID:11491533 NOTES:EC 3.5.1- KEGG RXN R02973 RM
name: Hydrolase Class ( RXN R02973)
reversible: false
product: MODEL1310110061#
fast: false
is: SBO:0000176

metaR PA HStn
is: SBO:0000185
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: NOTES:
product: MODEL1310110061#
kinetic law: MODEL1310110061#
type: Reaction
name: phosphatidate transport, nuclear
fast: false
reversible: true
reactant: MODEL1310110061#

metaR PEAMNO
type: Reaction
is: SBO:0000176
modifier: MODEL1310110061#
is version of: http://identifiers.org/ec-code/1.4.3.4
name: Phenethylamine oxidase
fast: false
reactant: MODEL1310110061#
is version of: http://identifiers.org/ec-code/1.4.3.21
product: MODEL1310110061#
is described by: ECO:0000304
kinetic law: MODEL1310110061#
reversible: false
notes: GENE_ASSOCIATION: (314.1) or (4128.1) or (26.1) or (4129.1) or (314.2) SUBSYSTEM: Phenylalanine metabolism EC Number: 1.4.3.6 Confidence Level: 2 AUTHORS: PMID:10389141,PMID:15035803,PMID:8920635,PMID:9653080 NOTES:JLR- Kegg reaction R02613
is version of: http://identifiers.org/ec-code/1.4.3.22

http://identifiers.org/biomodels.db/MODEL1310110061#_3be15b40_dbcc_4089_ba43_7681ee00fd58
type: Species
name: PLCB1
has only substance units: false
is: SBO:0000252
boundary condition: true
initial concentration: NaN
constant: false
is encoded by: hsa:23236
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110061#_59a01708_e93f_400b_b05c_6ad89074880b
type: Species
is: SBO:0000252
is: Q99624
constant: false
initial concentration: NaN
boundary condition: true
is encoded by: hsa:10991
name: SLC38A3
initial amount: NaN
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110061#_3bc68c6f_157c_4219_8bd3_d839c516d23e
constant: false
name: ELOVL1
is: Q9BW60
has only substance units: false
type: Species
initial amount: NaN
is encoded by: hsa:64834
is: SBO:0000252
boundary condition: true
initial concentration: NaN

metaM lcts g
is: SBO:0000247
initial amount: NaN
boundary condition: false
notes: FORMULA: C12H22O11 CHARGE: 0 INCHI: InChI=1S/C12H22O11/c13-1-3-5(15)6(16)9(19)12(22-3)23-10-4(2-14)21-11(20)8(18)7(10)17/h3-20H,1-2H2/t3-,4-,5+,6+,7-,8-,9-,10-,11?,12+/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00220 EHMN_ABBREVIATION: C00243
has only substance units: false
initial concentration: 1.0
type: Species
name: lactose
constant: false
is: HMDB00186
is: CHEBI:17716

metaR r0552
is: SBO:0000176
notes: GENE_ASSOCIATION: (AF080579.1) or (AI348006.1) or (6389.1) or (6390.1) or (6391.1) or (6392.1) or (642502.1) SUBSYSTEM: Glycine, serine, alanine and threonine metabolism EC Number: 1.2.1.8 Confidence Level: 0 AUTHORS: PMID:10505788,PMID:7646513 NOTES:
modifier: MODEL1310110061#
product: MODEL1310110061#
type: Reaction
is version of: http://identifiers.org/ec-code/1.3.5.1
fast: false
is described by: ECO:0000000
reactant: MODEL1310110061#
reversible: true
kinetic law: MODEL1310110061#
name: p-cumic alcohol:NAD+ oxidoreductase Glycine, serine and threonine metabolism EC:1.2.1.8

metaM adp r
name: ADP(3-)
is: SBO:0000247
notes: FORMULA: C10H12N5O10P2 CHARGE: -3 INCHI: InChI=1S/C10H15N5O10P2/c11-8-5-9(13-2-12-8)15(3-14-5)10-7(17)6(16)4(24-10)1-23-27(21,22)25-26(18,19)20/h2-4,6-7,10,16-17H,1H2,(H,21,22)(H2,11,12,13)(H2,18,19,20)/p-3/t4-,6-,7-,10-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00018 EHMN_ABBREVIATION: C00008
constant: false
initial concentration: 1.0
is: CHEBI:456216
is: HMDB01341
boundary condition: false
type: Species
initial amount: NaN
has only substance units: false

metaR MECOAS1m
fast: false
notes: GENE_ASSOCIATION: (8802.1 and 8801.1) SUBSYSTEM: C5-branched dibasic acid metabolism EC Number: 6.2.1.4 Confidence Level: 2 AUTHORS: PMID:13783048 NOTES:IF
modifier: MODEL1310110061#
is described by: ECO:0000304
reversible: true
kinetic law: MODEL1310110061#
reactant: MODEL1310110061#
type: Reaction
is version of: http://identifiers.org/ec-code/6.2.1.4
name: mesaconate--CoA ligase (GDP-forming)
product: MODEL1310110061#
is: SBO:0000176

metaR r1592
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is described by: ECO:0000000
is: SBO:0000185
product: MODEL1310110061#
reactant: MODEL1310110061#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
kinetic law: MODEL1310110061#
fast: false
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110061#_e090cc87_39b7_4424_a9c2_2f1382a4d518
boundary condition: true
is encoded by: hsa:728441
name: GGT2
constant: false
initial concentration: NaN
type: Species
is: SBO:0000252
initial amount: NaN
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110061#_1dff292c_9a8f_4cc5_ad77_6baaaa7ac370
constant: false
name: SLC20A2
type: Species
is: B2RBR4
initial amount: NaN
boundary condition: true
has only substance units: false
is encoded by: hsa:6575
initial concentration: NaN
is: SBO:0000252

metaR 4PYRDX
is: SBO:0000185
is described by: ECO:0000000
type: Reaction
kinetic law: MODEL1310110061#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:6380540 NOTES:IT Reaction correct??? (active transport)
name: 4-Pyridoxal secretion
reversible: false
product: MODEL1310110061#
fast: false
reactant: MODEL1310110061#

metaM 2dp6mep m
initial concentration: 1.0
initial amount: NaN
type: Species
boundary condition: false
constant: false
has only substance units: false
name: 2-Decaprenyl-6-methoxyphenol
is: SBO:0000247
notes: FORMULA: C57H88O2 CHARGE: 0 INCHI: InChI=1S/C57H88O2/c1-45(2)23-13-24-46(3)25-14-26-47(4)27-15-28-48(5)29-16-30-49(6)31-17-32-50(7)33-18-34-51(8)35-19-36-52(9)37-20-38-53(10)39-21-40-54(11)43-44-55-41-22-42-56(59-12)57(55)58/h22-23,25,27,29,31,33,35,37,39,41-43,58H,13-21,24,26,28,30,32,34,36,38,40,44H2,1-12H3/b46-25+,47-27+,48-29+,49-31+,50-33+,51-35+,52-37+,53-39+,54-43+
is: CHEBI:50774

metaR FACOAL1832
kinetic law: MODEL1310110061#
is described by: ECO:0000269
name: fatty-acid--CoA ligase
product: MODEL1310110061#
fast: false
reversible: true
reactant: MODEL1310110061#
modifier: MODEL1310110061#
type: Reaction
is: SBO:0000176
is version of: http://identifiers.org/ec-code/6.2.1.3
notes: GENE_ASSOCIATION: (2180.1) SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 4 AUTHORS: PMID:15292367 NOTES:NJ, RE3114C

metaR DHDPBMTm
reversible: false
type: Reaction
is version of: http://identifiers.org/ec-code/2.1.1.114
modifier: MODEL1310110061#
is described by: ECO:0000269
name: dihydroxydecaprenylbenzoate methyltransferase
product: MODEL1310110061#
fast: false
kinetic law: MODEL1310110061#
notes: GENE_ASSOCIATION: (51805.1) SUBSYSTEM: Ubiquinone synthesis EC Number: 2.1.1.114 Confidence Level: 4 AUTHORS: PMID:10777520,PMID:1965190,PMID:7380842 NOTES:Used to make Ubiquinone-10 EC 2.1.1.114 IT
is: SBO:0000176
reactant: MODEL1310110061#

metaR r0830
type: Reaction
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (2643.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:10585886,PMID:14598172,PMID:4424886,PMID:4441366,PMID:5099217,PMID:8329439 NOTES:
modifier: MODEL1310110061#
name: Mitochondrial Carrier (MC) TCDB:2.A.29.2.2
fast: false
product: MODEL1310110061#
reactant: MODEL1310110061#
kinetic law: MODEL1310110061#
is version of: http://identifiers.org/ec-code/3.5.4.16
is: SBO:0000185
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110061#_53ad94e7_c9ad_47d9_a1bd_bca6d32b72e5
has only substance units: false
is encoded by: hsa:8527
boundary condition: true
name: DGKD
is: SBO:0000252
type: Species
initial concentration: NaN
constant: false
initial amount: NaN

metaM crvnc e
has only substance units: false
initial concentration: 1.0
boundary condition: false
is: CHEBI:36005
notes: FORMULA: C22H31O2 CHARGE: -1
constant: false
type: Species
initial amount: NaN
name: cervonic acid, C22:6 n-3
is: SBO:0000247
is: HMDB02183

http://identifiers.org/biomodels.db/MODEL1310110061#_67bbf49e_fe67_44d3_b401_259928052d48
name: _AI345944_1_m
is encoded by: hsa:AI345944
boundary condition: true
has only substance units: false
initial amount: NaN
type: Species
initial concentration: NaN
constant: false
is: SBO:0000252

metaR FUMAC
modifier: MODEL1310110061#
name: fumarylacetoacetase
fast: false
notes: GENE_ASSOCIATION: (2184.1) SUBSYSTEM: Tyrosine metabolism EC Number: 3.7.1.2 Confidence Level: 4 AUTHORS: NOTES:NCD
product: MODEL1310110061#
type: Reaction
reversible: false
is: SBO:0000176
reactant: MODEL1310110061#
is version of: http://identifiers.org/ec-code/3.7.1.2
is described by: ECO:0000269
kinetic law: MODEL1310110061#

metaM ade e
is: HMDB00034
constant: false
initial amount: NaN
name: adenine
has only substance units: false
is: SBO:0000247
type: Species
is: CHEBI:16708
boundary condition: false
initial concentration: 1.0
notes: FORMULA: C5H5N5 CHARGE: 0 INCHI: InChI=1S/C5H5N5/c6-4-3-5(9-1-7-3)10-2-8-4/h1-2H,(H3,6,7,8,9,10) HEPATONET_1.0_ABBREVIATION: HC00144 EHMN_ABBREVIATION: C00147

metaR UAGDP
kinetic law: MODEL1310110061#
type: Reaction
notes: GENE_ASSOCIATION: (6675.1) or (91373.1) SUBSYSTEM: Aminosugar metabolism EC Number: 2.7.7.23 Confidence Level: 4 AUTHORS: PMID:9603950 NOTES:
fast: false
is version of: http://identifiers.org/ec-code/2.7.7.23
name: UDP-N-acetylglucosamine diphosphorylase
modifier: MODEL1310110061#
is: SBO:0000176
product: MODEL1310110061#
is described by: ECO:0000269
reactant: MODEL1310110061#
reversible: false

metaR r2330
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
fast: false
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
reactant: MODEL1310110061#
is: SBO:0000185
type: Reaction
product: MODEL1310110061#
is described by: ECO:0000000
kinetic law: MODEL1310110061#

metaM hdca c
has only substance units: false
initial amount: NaN
initial concentration: 1.0
constant: false
is: SBO:0000247
type: Species
notes: FORMULA: C16H31O2 CHARGE: -1 INCHI: InChI=1S/C16H32O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16(17)18/h2-15H2,1H3,(H,17,18)/p-1 HEPATONET_1.0_ABBREVIATION: HC00226 EHMN_ABBREVIATION: C00249
is: HMDB00220
boundary condition: false
name: palmitate
is: CHEBI:7896

http://identifiers.org/biomodels.db/MODEL1310110061#_40c07a24_5788_42d2_ab35_56b0596aaa02
initial concentration: NaN
constant: false
name: SLC4A5
type: Species
boundary condition: true
is: Q9BY07
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:57835
has only substance units: false

metaM pacald c
name: phenylacetaldehyde
boundary condition: false
notes: FORMULA: C8H8O CHARGE: 0 INCHI: InChI=1S/C8H8O/c9-7-6-8-4-2-1-3-5-8/h1-5,7H,6H2 HEPATONET_1.0_ABBREVIATION: HC00448 EHMN_ABBREVIATION: C00601
is: CHEBI:16424
is: HMDB06236
has only substance units: false
is: SBO:0000247
initial concentration: 1.0
initial amount: NaN
type: Species
constant: false

metaM leu L e
has only substance units: false
constant: false
is: SBO:0000247
notes: FORMULA: C6H13NO2 CHARGE: 0 INCHI: InChI=1S/C6H13NO2/c1-4(2)3-5(7)6(8)9/h4-5H,3,7H2,1-2H3,(H,8,9)/t5-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00121 EHMN_ABBREVIATION: C00123
initial amount: NaN
type: Species
is: CHEBI:15603
name: L-leucine
boundary condition: false
is: HMDB00687
initial concentration: 1.0

metaR UMPK5
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
name: UMP kinase (dATP)
modifier: MODEL1310110061#
is version of: http://identifiers.org/ec-code/2.7.4.14
is: SBO:0000176
reactant: MODEL1310110061#
reversible: true
fast: false
type: Reaction
is described by: ECO:0000269
product: MODEL1310110061#
kinetic law: MODEL1310110061#

metaR EX pan4p LPAREN e RPAREN
kinetic law: MODEL1310110061#
reactant: MODEL1310110061#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for pan4p
type: Reaction

metaM mlthf c
is: CHEBI:15636
notes: FORMULA: C20H21N7O6 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00140 EHMN_ABBREVIATION: C00143
initial amount: NaN
is: SBO:0000247
boundary condition: false
initial concentration: 1.0
is: C00143
constant: false
is: HMDB01533
name: 5,10-Methylenetetrahydrofolate
has only substance units: false
type: Species

metaR EX dcyt LPAREN e RPAREN
kinetic law: MODEL1310110061#
reactant: MODEL1310110061#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for Deoxycytidine
type: Reaction

metaM s7p c
notes: FORMULA: C7H13O10P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC01436 EHMN_ABBREVIATION: C05382
is: C05382
is: HMDB01068
is: SBO:0000247
constant: false
is: CHEBI:57483
type: Species
has only substance units: false
boundary condition: false
name: Sedoheptulose 7-phosphate
initial amount: NaN
initial concentration: 1.0

metaR FACOAL1831
reactant: MODEL1310110061#
name: fatty-acid--CoA ligase
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/6.2.1.3
fast: false
type: Reaction
modifier: MODEL1310110061#
is: SBO:0000176
kinetic law: MODEL1310110061#
product: MODEL1310110061#
notes: GENE_ASSOCIATION: (2180.1) SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 4 AUTHORS: PMID:15292367 NOTES:NJ
reversible: true

metaM gthox c
notes: FORMULA: C20H30N6O12S2 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00125 EHMN_ABBREVIATION: C00127
is: SBO:0000247
is: CHEBI:58297
type: Species
initial amount: NaN
has only substance units: false
is: HMDB03337
name: Oxidized glutathione
is: C00127
constant: false
initial concentration: 1.0
boundary condition: false

metaR RE3004M
kinetic law: MODEL1310110061#
product: MODEL1310110061#
fast: false
name: RE3004
is: SBO:0000176
reactant: MODEL1310110061#
is version of: http://identifiers.org/ec-code/2.3.1.16
reversible: true
is version of: http://identifiers.org/ec-code/4.2.1.17
modifier: MODEL1310110061#
notes: GENE_ASSOCIATION: (1892.1) or (3030.1) or (1962.1) or (3032.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.17 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:7775433 NOTES:
is version of: http://identifiers.org/ec-code/1.1.1.35
type: Reaction
is described by: ECO:0000000

metaR FAOXC102C103m
kinetic law: MODEL1310110061#
product: MODEL1310110061#
reactant: MODEL1310110061#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C10:2-->C10:3)m
type: Reaction

metaR EX sphs1p LPAREN e RPAREN
kinetic law: MODEL1310110061#
reactant: MODEL1310110061#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Sphingosine 1-phosphate exchange
type: Reaction

metaR r2331
reactant: MODEL1310110061#
type: Reaction
product: MODEL1310110061#
is described by: ECO:0000000
kinetic law: MODEL1310110061#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
fast: false
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
is: SBO:0000185
reversible: true

metaM pail5p hs n
initial amount: NaN
initial concentration: 1.0
constant: false
is: SBO:0000247
notes: FORMULA: C9H15O12P2FULLRCO2FULLR2CO2 CHARGE: -3
boundary condition: false
name: 1-phosphatidyl-1D-myo-inositol 5-phosphate(3-)
has only substance units: false
is: CHEBI:57795
type: Species

http://identifiers.org/biomodels.db/MODEL1310110061#_dc34bd33_94ca_4c37_b8ea_98c17d824d96
initial amount: NaN
is: SBO:0000252
boundary condition: true
has only substance units: false
type: Species
is: Q8NFF2
is encoded by: hsa:123041
constant: false
initial concentration: NaN
name: SLC24A4

metaM leuktrC4 r
notes: FORMULA: C30H45N3O9S CHARGE: -2 INCHI: InChI=1S/C30H47N3O9S/c1-2-3-4-5-6-7-8-9-10-11-12-13-16-25(24(34)15-14-17-27(36)37)43-21-23(29(40)32-20-28(38)39)33-26(35)19-18-22(31)30(41)42/h6-7,9-13,16,22-25,34H,2-5,8,14-15,17-21,31H2,1H3,(H,32,40)(H,33,35)(H,36,37)(H,38,39)(H,41,42)/p-2/b7-6-,10-9-,12-11+,16-13+/t22-,23-,24-,25+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00898 EHMN_ABBREVIATION: C02166
boundary condition: false
is: HMDB01198
constant: false
initial amount: NaN
name: leukotriene C4(2-)
initial concentration: 1.0
has only substance units: false
is: SBO:0000247
is: CHEBI:57973
type: Species

metaR UMPK6
is: SBO:0000176
reactant: MODEL1310110061#
reversible: true
is described by: ECO:0000269
name: UMP kinase (dCTP)
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
modifier: MODEL1310110061#
is version of: http://identifiers.org/ec-code/2.7.4.14
type: Reaction
product: MODEL1310110061#
kinetic law: MODEL1310110061#
fast: false

metaM glyc R c
initial amount: NaN
is: CHEBI:16659
notes: FORMULA: C3H5O4 CHARGE: -1 INCHI: InChI=1S/C3H6O4/c4-1-2(5)3(6)7/h2,4-5H,1H2,(H,6,7)/p-1/t2-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00235
initial concentration: 1.0
is: HMDB00139
constant: false
type: Species
name: D-glycerate
has only substance units: false
boundary condition: false
is: SBO:0000247

metaM cys L c
initial concentration: 1.0
initial amount: NaN
has only substance units: false
is: SBO:0000247
boundary condition: false
constant: false
name: L-cysteine
is: HMDB00574
is: CHEBI:17561
notes: FORMULA: C3H7NO2S CHARGE: 0 INCHI: InChI=1S/C3H7NO2S/c4-2(1-7)3(5)6/h2,7H,1,4H2,(H,5,6)/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00099
type: Species

metaR r1593
fast: false
product: MODEL1310110061#
type: Reaction
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reactant: MODEL1310110061#
reversible: true
is: SBO:0000185
kinetic law: MODEL1310110061#

http://identifiers.org/biomodels.db/MODEL1310110061#_b996c5ac_28ab_40f0_875b_47746ad0ee37
type: Species
is encoded by: hsa:AA614647
has only substance units: false
name: _AA614647_1_c
boundary condition: true
is: SBO:0000252
constant: false
initial concentration: NaN
initial amount: NaN

metaM sphmyln hs c
name: sphingomyelin betaine
is: SBO:0000247
has only substance units: false
initial amount: NaN
notes: FORMULA: C23H48N2O5PFULLRCO CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC02007
initial concentration: 1.0
boundary condition: false
type: Species
is: CHEBI:58216
constant: false

metaM amet m
has only substance units: false
type: Species
name: S-Adenosyl-L-methionine
constant: false
initial amount: NaN
notes: FORMULA: C15H23N6O5S CHARGE: 1 HEPATONET_1.0_ABBREVIATION: HC00029 EHMN_ABBREVIATION: C00019
is: SBO:0000247
initial concentration: 1.0
is: C00019
boundary condition: false
is: CHEBI:15414
is: HMDB01185

http://identifiers.org/biomodels.db/MODEL1310110061#_7547887a_f691_464d_a60d_78b58746e965
boundary condition: true
is: Q14916
is encoded by: hsa:6568
type: Species
initial amount: NaN
name: SLC17A1
initial concentration: NaN
has only substance units: false
is: SBO:0000252
constant: false

metaM 3hbcoa m
is: HMDB01166
notes: FORMULA: C25H38N7O18P3S CHARGE: -4 INCHI: InChI=1S/C25H42N7O18P3S/c1-13(33)8-16(35)54-7-6-27-15(34)4-5-28-23(38)20(37)25(2,3)10-47-53(44,45)50-52(42,43)46-9-14-19(49-51(39,40)41)18(36)24(48-14)32-12-31-17-21(26)29-11-30-22(17)32/h11-14,18-20,24,33,36-37H,4-10H2,1-3H3,(H,27,34)(H,28,38)(H,42,43)(H,44,45)(H2,26,29,30)(H2,39,40,41)/p-4/t13-,14+,18+,19+,20-,24+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00686 EHMN_ABBREVIATION: C01144
initial amount: NaN
type: Species
boundary condition: false
name: (S)-3-hydroxybutanoyl-CoA(4-)
is: CHEBI:57316
constant: false
is: SBO:0000247
has only substance units: false
initial concentration: 1.0

metaR LEUKTRD4t
product: MODEL1310110061#
name: leukotriene D4 transport
is described by: ECO:0000269
kinetic law: MODEL1310110061#
fast: false
reactant: MODEL1310110061#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10358072,PMID:12507753,PMID:9334206 NOTES:
type: Reaction
reversible: true
is: SBO:0000185

metaM cdpdag hs c
type: Species
is: SBO:0000247
initial amount: NaN
initial concentration: 1.0
boundary condition: false
is: CHEBI:58332
has only substance units: false
name: CDP-diacylglycerol(2-)
notes: FORMULA: C12H17N3O11P2FULLRCO2FULLR2CO2 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC02078
constant: false

metaM ade c
has only substance units: false
is: HMDB00034
constant: false
initial amount: NaN
name: Adenine
boundary condition: false
initial concentration: 1.0
is: SBO:0000247
is: CHEBI:16708
type: Species
notes: FORMULA: C5H5N5 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00144 EHMN_ABBREVIATION: C00147
is: C00147

metaM nad m
has only substance units: false
is: HMDB00902
initial concentration: 1.0
initial amount: NaN
is: http://identifiers.org/pubchem.compound/3305
is: CHEBI:57540
is: SBO:0000247
type: Species
name: Nicotinamide adenine dinucleotide
is: C00003
constant: false
boundary condition: false

metaR r1380
type: Reaction
fast: false
product: MODEL1310110061#
is: SBO:0000176
reversible: true
name: delta24-sterol reductase Biosynthesis of steroids EC:1.3.1.72
is described by: ECO:0000000
reactant: MODEL1310110061#
notes: GENE_ASSOCIATION: SUBSYSTEM: Cholesterol metabolism EC Number: 1.3.1.72 Confidence Level: 0 AUTHORS: PMID:12162789,PMID:9291139,PMID:9638657 NOTES:
kinetic law: MODEL1310110061#

metaR r1493
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:15845416 NOTES:
name: Utilized transport
is: SBO:0000185
is described by: ECO:0000000
reactant: MODEL1310110061#
fast: false
type: Reaction
product: MODEL1310110061#
reversible: false
kinetic law: MODEL1310110061#

metaM gly c
is: HMDB00123
is: SBO:0000247
name: Glycine
is: C00037
has only substance units: false
is: CHEBI:3339
initial concentration: 1.0
type: Species
initial amount: NaN
boundary condition: false
notes: FORMULA: C2H5NO2 CHARGE: 0
constant: false

http://identifiers.org/biomodels.db/MODEL1310110061#_1352c84c_de03_45aa_97c8_7cf9f3847ecc
initial amount: NaN
is encoded by: hsa:3632
is: SBO:0000252
has only substance units: false
is: Q14642
type: Species
boundary condition: true
initial concentration: NaN
constant: false
name: INPP5A

metaR r1400
kinetic law: MODEL1310110061#
reversible: false
type: Reaction
fast: false
is described by: ECO:0000000
name: Active transport
product: MODEL1310110061#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 0 AUTHORS: PMID:12133002,PMID:4475632,PMID:5810070 NOTES:
reactant: MODEL1310110061#

metaR r2332
reversible: true
fast: false
is: SBO:0000185
type: Reaction
reactant: MODEL1310110061#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
kinetic law: MODEL1310110061#
product: MODEL1310110061#

http://identifiers.org/biomodels.db/MODEL1310110061#_f0fe1cbf_243c_4efc_a532_b00a93304e76
boundary condition: true
type: Species
constant: false
name: SLC43A1
is: O75387
is encoded by: hsa:8501
has only substance units: false
initial amount: NaN
is: SBO:0000252
initial concentration: NaN

metaM xol27oh r
constant: false
notes: FORMULA: C27H46O2 CHARGE: 0 INCHI: InChI=1S/C27H46O2/c1-18(17-28)6-5-7-19(2)23-10-11-24-22-9-8-20-16-21(29)12-14-26(20,3)25(22)13-15-27(23,24)4/h8,18-19,21-25,28-29H,5-7,9-17H2,1-4H3/t18?,19-,21+,22+,23-,24+,25+,26+,27-/m1/s1 EHMN_ABBREVIATION: C06340
is: CHEBI:17703
is: SBO:0000247
initial concentration: 1.0
is: HMDB02103
has only substance units: false
type: Species
initial amount: NaN
boundary condition: false
name: 26-hydroxycholesterol

metaM HC00718 c
is: SBO:0000247
name: N-methylethanolaminium phosphate(1-)
notes: FORMULA: C3H9NO4P CHARGE: -1 INCHI: InChI=1S/C3H10NO4P/c1-4-2-3-8-9(5,6)7/h4H,2-3H2,1H3,(H2,5,6,7)/p-1
has only substance units: false
initial amount: NaN
type: Species
is: CHEBI:57781
initial concentration: 1.0
constant: false
boundary condition: false

metaR UMPK7
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
is: SBO:0000176
reactant: MODEL1310110061#
name: UMP kinase (dGTP)
product: MODEL1310110061#
type: Reaction
modifier: MODEL1310110061#
fast: false
is version of: http://identifiers.org/ec-code/2.7.4.14
kinetic law: MODEL1310110061#
reversible: true

metaR ASNCYSNaEx
kinetic law: MODEL1310110061#
reversible: false
notes: GENE_ASSOCIATION: (6510.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14530974 NOTES:SAB see Kanai and Hediger 2004 (2003), PMID 14530974
type: Reaction
modifier: MODEL1310110061#
reactant: MODEL1310110061#
product: MODEL1310110061#
is described by: ECO:0000269
name: L-cysteine/L-asparagine Na-dependent exchange (Asn-L in)
is: SBO:0000185
fast: false

metaR r1594
is: SBO:0000185
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reversible: true
fast: false
reactant: MODEL1310110061#
kinetic law: MODEL1310110061#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
product: MODEL1310110061#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110061#_4abfe877_f3bb_4eb1_85c9_cd3ca67401a4
constant: false
boundary condition: true
name: AMY1A
is: SBO:0000252
is: Q6NSB3
type: Species
is encoded by: hsa:276
has only substance units: false
initial concentration: NaN
initial amount: NaN

metaM leu L c
constant: false
is: SBO:0000247
type: Species
initial amount: NaN
boundary condition: false
name: L-leucine
is: CHEBI:15603
initial concentration: 1.0
has only substance units: false
is: HMDB00687
notes: FORMULA: C6H13NO2 CHARGE: 0 INCHI: InChI=1S/C6H13NO2/c1-4(2)3-5(7)6(8)9/h4-5H,3,7H2,1-2H3,(H,8,9)/t5-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00121 EHMN_ABBREVIATION: C00123

http://identifiers.org/biomodels.db/MODEL1310110061#_477842c9_771d_4760_96f2_f1f93280422b
boundary condition: true
initial amount: NaN
is: SBO:0000252
type: Species
name: GPX5
is encoded by: hsa:2880
initial concentration: NaN
has only substance units: false
constant: false
is: O75715

metaR EX ade LPAREN e RPAREN
kinetic law: MODEL1310110061#
reactant: MODEL1310110061#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Adenine exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110061#_4f7f7852_c162_421f_bafa_3f9fe318debe
initial concentration: NaN
is: P54687
name: BCAT1
boundary condition: true
constant: false
type: Species
is: SBO:0000252
is encoded by: hsa:586
initial amount: NaN
has only substance units: false

metaR r1381
product: MODEL1310110061#
is: SBO:0000176
reversible: true
is described by: ECO:0000000
reactant: MODEL1310110061#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Cholesterol metabolism EC Number: 5.3.3.5 Confidence Level: 0 AUTHORS: PMID:12133002,PMID:4475632,PMID:5810070 NOTES:
name: 5alpha-Cholest-7-en-3beta-ol delta7-delta8-isomerase Biosynthesis of steroids EC:5.3.3.5
kinetic law: MODEL1310110061#
type: Reaction

metaM 25aics c
is: SBO:0000247
is: HMDB00797
constant: false
is: CHEBI:58443
initial amount: NaN
notes: FORMULA: C13H15N4O12P CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC01356 EHMN_ABBREVIATION: C04823
initial concentration: 1.0
has only substance units: false
name: (S)-2-[5-Amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamido]succinate
boundary condition: false
type: Species
is: C04823

metaM 34dhmald c
initial amount: NaN
is: HMDB06242
has only substance units: false
boundary condition: false
name: 3,4-Dihydroxymandelaldehyde
notes: FORMULA: C8H8O4 CHARGE: 0 INCHI: InChI=1/C8H8O4/c9-4-8(12)5-1-2-6(10)7(11)3-5/h1-4,8,10-12H HEPATONET_1.0_ABBREVIATION: HC01514 EHMN_ABBREVIATION: C05577
is: http://identifiers.org/pubchem.compound/7903
initial concentration: 1.0
is: C05577
constant: false
is: SBO:0000247
type: Species

metaM glcur l
has only substance units: false
constant: false
is: CHEBI:15748
is: HMDB00127
boundary condition: false
is: SBO:0000247
initial amount: NaN
name: D-glucuronate
type: Species
notes: FORMULA: C6H9O7 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00182 EHMN_ABBREVIATION: C00191
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110061#_ad317ebb_a947_4230_ac84_8ee31d08e8d1
initial amount: NaN
is: SBO:0000252
constant: false
has only substance units: false
name: CHAT
is encoded by: hsa:1103
initial concentration: NaN
is: Q6LEN5
boundary condition: true
type: Species

http://identifiers.org/biomodels.db/MODEL1310110061#_1b3be56c_f1b7_4c60_85db_4bd407128615
is encoded by: hsa:55825
is: Q9BY49
has only substance units: false
initial amount: NaN
name: PECR
type: Species
is: SBO:0000252
constant: false
boundary condition: true
initial concentration: NaN

metaM dhcholestanate x
is: SBO:0000247
constant: false
is: HMDB00359
notes: FORMULA: C27H45O4 CHARGE: -1 INCHI: InChI=1S/C27H46O4/c1-16(6-5-7-17(2)25(30)31)20-8-9-21-24-22(11-13-27(20,21)4)26(3)12-10-19(28)14-18(26)15-23(24)29/h16-24,28-29H,5-15H2,1-4H3,(H,30,31)/t16-,17?,18+,19-,20-,21+,22+,23-,24+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01313 EHMN_ABBREVIATION: C04554
initial amount: NaN
name: 3alpha,7alpha-Dihydroxy-5beta-cholestanate
type: Species
boundary condition: false
initial concentration: 1.0
has only substance units: false
is: CHEBI:16577

metaR r2333
reactant: MODEL1310110061#
is described by: ECO:0000000
kinetic law: MODEL1310110061#
product: MODEL1310110061#
fast: false
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
reversible: true
type: Reaction

metaR r1595
fast: false
type: Reaction
product: MODEL1310110061#
is described by: ECO:0000000
reactant: MODEL1310110061#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reversible: true
is: SBO:0000185
kinetic law: MODEL1310110061#

metaM kynate c
initial amount: NaN
has only substance units: false
constant: false
is: CHEBI:58454
initial concentration: 1.0
name: kynurenate
is: HMDB00715
boundary condition: false
is: SBO:0000247
type: Species
notes: FORMULA: C10H6NO3 CHARGE: -1 INCHI: InChI=1S/C10H7NO3/c12-9-5-8(10(13)14)11-7-4-2-1-3-6(7)9/h1-5H,(H,11,12)(H,13,14)/p-1 EHMN_ABBREVIATION: C01717

metaM cys L e
initial concentration: 1.0
is: SBO:0000247
has only substance units: false
constant: false
is: HMDB00574
boundary condition: false
is: CHEBI:17561
name: L-cysteine
notes: FORMULA: C3H7NO2S CHARGE: 0 INCHI: InChI=1S/C3H7NO2S/c4-2(1-7)3(5)6/h2,7H,1,4H2,(H,5,6)/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00099
type: Species
initial amount: NaN

metaM HC00229 e
notes: FORMULA: C12H22O11 CHARGE: 0 INCHI: InChI=1S/C12H22O11/c13-1-4(15)7(17)8(18)5(16)3-22-12-11(21)10(20)9(19)6(2-14)23-12/h1,4-12,14-21H,2-3H2/t4-,5+,6+,7+,8+,9+,10-,11+,12-/m0/s1 EHMN_ABBREVIATION: C00252
is: CHEBI:28189
name: Isomaltose
initial amount: NaN
has only substance units: false
initial concentration: 1.0
type: Species
constant: false
is: SBO:0000247
boundary condition: false

metaR r1929
kinetic law: MODEL1310110061#
reversible: false
name: Y+LAT2 Utilized transport
product: MODEL1310110061#
modifier: MODEL1310110061#
fast: false
reactant: MODEL1310110061#
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is described by: ECO:0000000
is: SBO:0000185
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110061#_1d83b70c_b34a_4e87_90c4_c22f89df1e12
type: Species
is: B3KXN9
boundary condition: true
is encoded by: hsa:84890
initial concentration: NaN
constant: false
is: SBO:0000252
has only substance units: false
initial amount: NaN
name: ADO

metaM oaa c
is: C00036
is: HMDB00223
name: Oxaloacetate
notes: FORMULA: C4H2O5 CHARGE: -2
initial concentration: 1.0
has only substance units: false
constant: false
is: SBO:0000247
initial amount: NaN
boundary condition: false
is: CHEBI:3338
type: Species

http://identifiers.org/biomodels.db/MODEL1310110061#_69c91423_4859_4a01_ab3e_6139a311f5ef
boundary condition: true
name: PTGS1
initial amount: NaN
initial concentration: NaN
is: P23219
constant: false
is: SBO:0000252
is encoded by: hsa:5742
type: Species
has only substance units: false

metaR DNDPt10m
kinetic law: MODEL1310110061#
reversible: false
type: Reaction
fast: false
notes: GENE_ASSOCIATION: (60386.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:11226231 NOTES:IT
modifier: MODEL1310110061#
product: MODEL1310110061#
is: SBO:0000185
name: dADP transport via dCDP antiport
is described by: ECO:0000269
reactant: MODEL1310110061#

metaR 34DHXMANDACOX NADP
is version of: http://identifiers.org/ec-code/1.2.1.5
name: 3,4-Dihydroxymandelaldehyde:NADP+ oxidoreductase
type: Reaction
fast: false
notes: GENE_ASSOCIATION: (221.1) or (222.1) SUBSYSTEM: Tyrosine metabolism EC Number: 1.2.1.5 Confidence Level: 4 AUTHORS: PMID:10424772,PMID:12616643 NOTES:SAB
modifier: MODEL1310110061#
is described by: ECO:0000269
is: SBO:0000176
product: MODEL1310110061#
reversible: true
reactant: MODEL1310110061#
kinetic law: MODEL1310110061#

metaM chlstol r
is: SBO:0000247
boundary condition: false
is: HMDB06842
notes: FORMULA: C27H44O CHARGE: 0 INCHI: InChI=1S/C27H44O/c1-18(2)7-6-8-19(3)23-11-12-24-22-10-9-20-17-21(28)13-15-26(20,4)25(22)14-16-27(23,24)5/h7,10,19-21,23-25,28H,6,8-9,11-17H2,1-5H3/t19-,20+,21+,23-,24+,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01452 EHMN_ABBREVIATION: C05439
name: 5alpha-cholesta-7,24-dien-3beta-ol
has only substance units: false
initial amount: NaN
initial concentration: 1.0
is: CHEBI:16290
constant: false
type: Species

metaM betald c
notes: FORMULA: C5H12NO CHARGE: 1 INCHI: InChI=1S/C5H12NO/c1-6(2,3)4-5-7/h5H,4H2,1-3H3/q+1 HEPATONET_1.0_ABBREVIATION: HC00435 EHMN_ABBREVIATION: C00576
is: HMDB01252
has only substance units: false
name: betaine aldehyde
is: SBO:0000247
is: CHEBI:15710
boundary condition: false
initial concentration: 1.0
type: Species
initial amount: NaN
constant: false

metaM val L c
boundary condition: false
notes: FORMULA: C5H11NO2 CHARGE: 0 INCHI: InChI=1S/C5H11NO2/c1-3(2)4(6)5(7)8/h3-4H,6H2,1-2H3,(H,7,8)/t4-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00174
has only substance units: false
is: SBO:0000247
is: CHEBI:16414
type: Species
constant: false
initial amount: NaN
initial concentration: 1.0
name: L-valine
is: HMDB00883

metaR r0834
fast: false
kinetic law: MODEL1310110061#
type: Reaction
is described by: ECO:0000000
product: MODEL1310110061#
is: SBO:0000185
notes: GENE_ASSOCIATION: (2643.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:10585886,PMID:14598172,PMID:4424886,PMID:4441366,PMID:5099217,PMID:8329439 NOTES:
reactant: MODEL1310110061#
reversible: true
modifier: MODEL1310110061#
name: Mitochondrial Carrier (MC) TCDB:2.A.29.2.2
is version of: http://identifiers.org/ec-code/3.5.4.16

metaM lnlccrn c
constant: false
name: Linoleyl carnitine
notes: FORMULA: C25H45NO4 CHARGE: 0 INCHI: InChI=1/C25H45NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-25(29)30-23(21-24(27)28)22-26(2,3)4/h9-10,12-13,23H,5-8,11,14-22H2,1-4H3/b10-9-,13-12-/t23-/m1/s1
is: HMDB06469
has only substance units: false
is: SBO:0000247
initial amount: NaN
type: Species
initial concentration: 1.0
boundary condition: false

metaR r1928
fast: false
reversible: false
modifier: MODEL1310110061#
kinetic law: MODEL1310110061#
product: MODEL1310110061#
name: Y+LAT2 Utilized transport
reactant: MODEL1310110061#
is: SBO:0000185
is described by: ECO:0000000
type: Reaction
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:

metaR NDPK6m
is version of: http://identifiers.org/ec-code/2.7.4.6
is: SBO:0000176
modifier: MODEL1310110061#
name: nucleoside-diphosphate kinase (ATP:dUDP), mitochondrial
type: Reaction
notes: GENE_ASSOCIATION: (4833.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.6 Confidence Level: 2 AUTHORS: PMID:9099850 NOTES:Many nucleoside diphosphates (eight described) can act as acceptors. While many ribo- and deoxyribonucleoside triphosphates can act as donors, only ATP is chosen as a donor to minimize the number of total reactions.
fast: false
reactant: MODEL1310110061#
is described by: ECO:0000254
kinetic law: MODEL1310110061#
reversible: true
product: MODEL1310110061#

http://identifiers.org/biomodels.db/MODEL1310110061#_d136577c_c538_411f_a8a9_e566a1044ed1
type: Species
is: SBO:0000252
boundary condition: true
name: RDH10
is: Q8IZV5
initial amount: NaN
constant: false
has only substance units: false
initial concentration: NaN
is encoded by: hsa:157506

metaR r0027
notes: GENE_ASSOCIATION: (285973.1) or (D29675.1) or (4842.1) or (NOS2A.1) or (4846.1) SUBSYSTEM: Methionine and cysteine metabolism EC Number: 1.8.1.9 Confidence Level: 0 AUTHORS: PMID:18042542 NOTES:
reversible: true
fast: false
modifier: MODEL1310110061#
product: MODEL1310110061#
name: NADPH:CoA-glutathione oxidoreductase EC:1.8.1.9
is: SBO:0000176
type: Reaction
reactant: MODEL1310110061#
is version of: http://identifiers.org/ec-code/1.14.13.39
kinetic law: MODEL1310110061#
is described by: ECO:0000000

metaR FAOXC164C165m
kinetic law: MODEL1310110061#
product: MODEL1310110061#
reactant: MODEL1310110061#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C16:4-->C16:5)m
type: Reaction

metaM cyan e
has only substance units: false
initial amount: NaN
type: Species
initial concentration: 1.0
is: HMDB02084
is: CHEBI:18407
boundary condition: false
is: SBO:0000247
constant: false
notes: FORMULA: CHN CHARGE: 0 INCHI: InChI=1S/CHN/c1-2/h1H EHMN_ABBREVIATION: C01326
name: hydrogen cyanide

metaR EX paf hs LPAREN e RPAREN
kinetic law: MODEL1310110061#
reactant: MODEL1310110061#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 1-alkyl 2-acteylglycerol 3-phosphocholine (homo sapiens) exchange
type: Reaction

metaR r1739
modifier: MODEL1310110061#
name: Y+LAT2 Utilized transport
product: MODEL1310110061#
type: Reaction
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is: SBO:0000185
reactant: MODEL1310110061#
fast: false
is described by: ECO:0000000
kinetic law: MODEL1310110061#
reversible: false

metaM HC01104 e
initial concentration: 1.0
type: Species
name: 4-nitrophenyl phosphate(2-)
notes: FORMULA: C6H4NO6P CHARGE: -2 INCHI: InChI=1S/C6H6NO6P/c8-7(9)5-1-3-6(4-2-5)13-14(10,11)12/h1-4H,(H2,10,11,12)/p-2 EHMN_ABBREVIATION: C03360
is: SBO:0000247
has only substance units: false
boundary condition: false
initial amount: NaN
constant: false
is: CHEBI:61146

metaM nicrnt c
is: SBO:0000247
boundary condition: false
has only substance units: false
constant: false
is: CHEBI:57502
initial concentration: 1.0
is: C01185
initial amount: NaN
name: Nicotinate D-ribonucleotide
type: Species
is: HMDB01132
notes: FORMULA: C11H12NO9P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00703 EHMN_ABBREVIATION: C01185

http://identifiers.org/biomodels.db/MODEL1310110061#_54f28d2d_751d_4cc9_8946_174b4586a380
name: VNN2
initial amount: NaN
boundary condition: true
constant: false
is: A8K7W0
is encoded by: hsa:8875
type: Species
has only substance units: false
is: SBO:0000252
initial concentration: NaN

metaM 5forthf c
boundary condition: false
is: CHEBI:57456
is: SBO:0000247
constant: false
is: C00664
name: 5-Formiminotetrahydrofolate
type: Species
has only substance units: false
notes: FORMULA: C20H22N8O6 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00483 EHMN_ABBREVIATION: C00664
initial amount: NaN
is: HMDB01534
initial concentration: 1.0

metaR ASNNm
is version of: http://identifiers.org/ec-code/3.5.1.1
name: L-asparaginase (mitochondrial)
kinetic law: MODEL1310110061#
product: MODEL1310110061#
fast: false
reactant: MODEL1310110061#
is described by: ECO:0000254
notes: GENE_ASSOCIATION: (80150.1) SUBSYSTEM: Alanine and aspartate metabolism EC Number: 3.5.1.1 Confidence Level: 2 AUTHORS: PMID:11984834 NOTES:PMID: 11984834 (denotes it as potentially mitochondrial) mm
modifier: MODEL1310110061#
is: SBO:0000176
type: Reaction
reversible: false

metaM pe hs c
constant: false
boundary condition: false
notes: FORMULA: C5H12NO4PFULLRCO2FULLR2CO2 CHARGE: 0
type: Species
is: CHEBI:16038
has only substance units: false
initial concentration: 1.0
initial amount: NaN
name: phosphatidylethanolamine
is: SBO:0000247

metaM nad r
is: HMDB00902
notes: FORMULA: C21H26N7O14P2 CHARGE: -1 INCHI: InChI=1S/C21H27N7O14P2/c22-17-12-19(25-7-24-17)28(8-26-12)21-16(32)14(30)11(41-21)6-39-44(36,37)42-43(34,35)38-5-10-13(29)15(31)20(40-10)27-3-1-2-9(4-27)18(23)33/h1-4,7-8,10-11,13-16,20-21,29-32H,5-6H2,(H5-,22,23,24,25,33,34,35,36,37)/p-1/t10-,11-,13-,14-,15-,16-,20-,21-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00013 EHMN_ABBREVIATION: C00003
type: Species
name: NAD(1-)
is: SBO:0000247
constant: false
has only substance units: false
initial amount: NaN
is: CHEBI:57540
initial concentration: 1.0
boundary condition: false

metaR PPA
modifier: MODEL1310110061#
reversible: false
reactant: MODEL1310110061#
is version of: http://identifiers.org/ec-code/3.6.1.1
kinetic law: MODEL1310110061#
product: MODEL1310110061#
type: Reaction
notes: GENE_ASSOCIATION: (5464.1) SUBSYSTEM: Oxidative phosphorylation EC Number: 3.6.1.1 Confidence Level: 4 AUTHORS: PMID:10542310,PMID:15533045 NOTES:
name: inorganic diphosphatase
is: SBO:0000176
fast: false
is described by: ECO:0000269

metaR 5HOXINDACTO2OX
is described by: ECO:0000304
is: SBO:0000176
modifier: MODEL1310110061#
fast: false
is version of: http://identifiers.org/ec-code/1.2.3.1
reversible: false
kinetic law: MODEL1310110061#
notes: GENE_ASSOCIATION: (316.1) SUBSYSTEM: Tryptophan metabolism EC Number: 1.2.3.1 Confidence Level: 2 AUTHORS: PMID:11306106 NOTES:SAB questionable--balanced, but h2o2 production is based on an obscure comment in entrez
product: MODEL1310110061#
type: Reaction
reactant: MODEL1310110061#
name: 5-Hydroxyindoleacetaldehyde:oxygen oxidoreductase

metaM galgluside hs g
has only substance units: false
is: C00015
boundary condition: false
type: Species
initial amount: NaN
constant: false
is: CHEBI:58223
name: galactosyl glucosyl ceramide
is: SBO:0000247
notes: FORMULA: C30H56NO12FULLRCO CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC02162
is: HMDB00295
initial concentration: 1.0

metaR CYSASNNaEx
type: Reaction
name: L-cysteine/L-asparagine Na-dependent exchange (Cys-L in)
reactant: MODEL1310110061#
product: MODEL1310110061#
is described by: ECO:0000269
reversible: false
kinetic law: MODEL1310110061#
is: SBO:0000185
notes: GENE_ASSOCIATION: (6510.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14530974 NOTES:SAB see Kanai and Hediger 2004 (2003), PMID 14530974
fast: false
modifier: MODEL1310110061#

http://identifiers.org/biomodels.db/MODEL1310110061#_51bbed56_f123_4d10_962d_6db12266702c
boundary condition: true
is: Q53F23
initial concentration: NaN
is: SBO:0000252
constant: false
initial amount: NaN
is encoded by: hsa:6916
name: TBXAS1
has only substance units: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110061#_1506b04a_ebd5_400a_bb78_355a58f7d64d
is: SBO:0000252
is: P49619
initial concentration: NaN
initial amount: NaN
type: Species
name: DGKG
constant: false
boundary condition: true
has only substance units: false
is encoded by: hsa:1608

metaR r0549
is version of: http://identifiers.org/ec-code/1.6.99.3
kinetic law: MODEL1310110061#
product: MODEL1310110061#
reactant: MODEL1310110061#
modifier: MODEL1310110061#
notes: GENE_ASSOCIATION: (AA629629.1) or (AA854479.1) or (AI345944.1) or (AI378339.1) or (AI601100.1) or (AI631997.1) or (AI935189.1) or (124454.1) or (F23536.1) or (FLJ44968.1) or (H45672.1) or (H53099.1) or (3550.1) or (LOC727762.1) or (4694.1) or (4705.1) or (126328.1) or (55967.1) or (51079.1) or (4695.1) or (4696.1) or (4697.1) or (56901.1) or (4698.1) or (4700.1) or (4701.1) or (4702.1) or (4704.1) or (4706.1) or (4707.1) or (4716.1) or (54539.1) or (4708.1) or (4709.1) or (4710.1) or (4711.1) or (4712.1) or (4713.1) or (4714.1) or (4715.1) or (4717.1) or (4718.1) or (4719.1) or (4720.1) or (4722.1) or (4724.1) or (4725.1) or (4726.1) or (374291.1) or (4728.1) or (4723.1) or (4729.1) or (4731.1) SUBSYSTEM: Glutamate metabolism EC Number: 1.2.1.3 Confidence Level: 0 AUTHORS: PMID:2925663,PMID:8155713,PMID:8269919,PMID:8786138,PMID:9417993 NOTES:
is described by: ECO:0000000
name: 4-aminobutanal:NAD+ 1-oxidoreductase; 4-aminobutyraldehyde:NAD+ oxidoreductase Urea cycle and metabolism of amino groups / beta-Alanine metabolism EC:1.2.1.3 EC:1.2.1.19
is version of: http://identifiers.org/ec-code/6.1.1.17
is version of: http://identifiers.org/ec-code/1.6.5.3
is: SBO:0000176
fast: false
reversible: true
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110061#_9c34a5e6_9a25_4004_82c7_f5c5e3f6e4a5
boundary condition: true
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:6574
name: SLC20A1
has only substance units: false
is: SBO:0000252
type: Species
constant: false
is: Q8WUM9

metaR HISTAtu
reactant: MODEL1310110061#
type: Reaction
modifier: MODEL1310110061#
name: Histamine uniport
is: SBO:0000185
product: MODEL1310110061#
fast: false
notes: GENE_ASSOCIATION: (6581.1) or (6582.2) or (6582.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12883891 NOTES:SAB electrogenic, Na indepdendent & rev NJ
reversible: true
is described by: ECO:0000269
kinetic law: MODEL1310110061#

metaR r1512
product: MODEL1310110061#
reactant: MODEL1310110061#
name: Utilized transport
kinetic law: MODEL1310110061#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
type: Reaction
reversible: false
is described by: ECO:0000000
is: SBO:0000185
fast: false

metaR EX cit LPAREN e RPAREN
kinetic law: MODEL1310110061#
reactant: MODEL1310110061#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Citrate exchange
type: Reaction

metaM cyst L c
initial concentration: 1.0
boundary condition: false
constant: false
name: L-cystathionine
initial amount: NaN
is: CHEBI:17482
is: SBO:0000247
notes: FORMULA: C7H14N2O4S CHARGE: 0 INCHI: InChI=1S/C7H14N2O4S/c8-4(6(10)11)1-2-14-3-5(9)7(12)13/h4-5H,1-3,8-9H2,(H,10,11)(H,12,13)/t4-,5-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00916
is: HMDB00099
has only substance units: false
type: Species

metaR EX ak2lgchol hs LPAREN e RPAREN
kinetic law: MODEL1310110061#
reactant: MODEL1310110061#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 1-alkyl 2-lysoglycerol 3-phosphocholine exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110061#_e72c5c0c_dd89_45a7_8542_2202cbb64973
name: SLC16A7
boundary condition: true
type: Species
is: Q8NEM3
is: SBO:0000252
constant: false
is encoded by: hsa:9194
initial amount: NaN
has only substance units: false
initial concentration: NaN

metaM tdec4ecoa m
is: SBO:0000247
is: HMDB06522
initial concentration: 1.0
name: trans4decenoylcoa
boundary condition: false
type: Species
has only substance units: false
notes: FORMULA: C31H48N7O17P3S CHARGE: -4
constant: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110061#_66a9b26d_aa06_4875_95cb_d4e87523975d
boundary condition: true
name: SLCO1B1
type: Species
has only substance units: false
is encoded by: hsa:10599
initial amount: NaN
constant: false
initial concentration: NaN
is: SBO:0000252
is: Q9Y6L6

metaR NAHCO3 HCLt
modifier: MODEL1310110061#
type: Reaction
reactant: MODEL1310110061#
is: SBO:0000185
name: bicarbonate transport (HCl/NaHCO3 exchange)
fast: false
is described by: ECO:0000269
kinetic law: MODEL1310110061#
product: MODEL1310110061#
reversible: true
notes: GENE_ASSOCIATION: (9498.1) or (57282.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14722772 NOTES:MM

metaM crvnc c
constant: false
is: SBO:0000247
type: Species
has only substance units: false
name: cervonic acid, C22:6 n-3
notes: FORMULA: C22H31O2 CHARGE: -1
boundary condition: false
is: CHEBI:36005
initial amount: NaN
initial concentration: 1.0
is: HMDB02183

metaR EX 10fthf5glu LPAREN e RPAREN
kinetic law: MODEL1310110061#
reactant: MODEL1310110061#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 10-formyltetrahydrofolate-[Glu](5) exchange
type: Reaction

metaM r1p c
is: HMDB01489
has only substance units: false
constant: false
initial amount: NaN
notes: FORMULA: C5H9O8P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00456 EHMN_ABBREVIATION: C00442
boundary condition: false
type: Species
name: alpha-D-Ribose 1-phosphate
is: CHEBI:57720
initial concentration: 1.0
is: SBO:0000247
is: C00442

metaM xol27oh m
is: HMDB02103
constant: false
boundary condition: false
notes: FORMULA: C27H46O2 CHARGE: 0 INCHI: InChI=1S/C27H46O2/c1-18(17-28)6-5-7-19(2)23-10-11-24-22-9-8-20-16-21(29)12-14-26(20,3)25(22)13-15-27(23,24)4/h8,18-19,21-25,28-29H,5-7,9-17H2,1-4H3/t18?,19-,21+,22+,23-,24+,25+,26+,27-/m1/s1 EHMN_ABBREVIATION: C06340
initial amount: NaN
initial concentration: 1.0
type: Species
is: CHEBI:17703
name: 26-hydroxycholesterol
has only substance units: false
is: SBO:0000247

metaR FAS80COA L
modifier: MODEL1310110061#
product: MODEL1310110061#
is described by: ECO:0000269
kinetic law: MODEL1310110061#
notes: GENE_ASSOCIATION: (2194.1) SUBSYSTEM: Fatty acid synthesis EC Number: 2.3.1.86 Confidence Level: 4 AUTHORS: PMID:11756679,PMID:15507492,PMID:2669958 NOTES:NCD
reversible: false
reactant: MODEL1310110061#
is version of: http://identifiers.org/ec-code/2.3.1.85
name: fatty acyl-CoA synthase (n-C8:0CoA), lumped reaction
is: SBO:0000176
fast: false
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110061#_7230e933_1ebb_4a2d_ac2a_83c04fe76b92
is encoded by: hsa:286297
has only substance units: false
type: Species
constant: false
name: _286297_1_c
initial amount: NaN
is: SBO:0000252
initial concentration: NaN
boundary condition: true

metaR FAOXC101C8m
kinetic law: MODEL1310110061#
product: MODEL1310110061#
reactant: MODEL1310110061#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C10:1-->C8)m
type: Reaction

metaM gdpddman c
is: CHEBI:57964
is: SBO:0000247
boundary condition: false
initial amount: NaN
is: HMDB01346
initial concentration: 1.0
has only substance units: false
name: GDP-4-dehydro-6-deoxy-alpha-D-mannose(2-)
constant: false
type: Species
notes: FORMULA: C16H21N5O15P2 CHARGE: -2 INCHI: InChI=1S/C16H23N5O15P2/c1-4-7(22)9(24)11(26)15(33-4)35-38(30,31)36-37(28,29)32-2-5-8(23)10(25)14(34-5)21-3-18-6-12(21)19-16(17)20-13(6)27/h3-5,8-11,14-15,23-26H,2H2,1H3,(H,28,29)(H,30,31)(H3,17,19,20,27)/p-2/t4-,5-,8-,9+,10-,11+,14-,15-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00728 EHMN_ABBREVIATION: C01222

metaR DHAAt1r
modifier: MODEL1310110061#
product: MODEL1310110061#
kinetic law: MODEL1310110061#
reversible: true
notes: GENE_ASSOCIATION: (6515.1) or (6513.1) or (6517.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10421229,PMID:12750891,PMID:15705056,PMID:2656669,PMID:3170580,PMID:8504756,PMID:9230074 NOTES:NCD
is: SBO:0000185
name: dehydroascorbate transport (uniport)
fast: false
is described by: ECO:0000269
type: Reaction
reactant: MODEL1310110061#

http://identifiers.org/biomodels.db/MODEL1310110061#_39bf2071_c320_426b_8126_548ef857de71
constant: false
has only substance units: false
initial amount: NaN
type: Species
is encoded by: hsa:57468
initial concentration: NaN
boundary condition: true
name: SLC12A5
is: Q9H2X9
is: SBO:0000252

metaR UMPK2
kinetic law: MODEL1310110061#
modifier: MODEL1310110061#
reversible: true
reactant: MODEL1310110061#
is: SBO:0000176
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
type: Reaction
product: MODEL1310110061#
name: UMP kinase (CTP)
fast: false
is version of: http://identifiers.org/ec-code/2.7.4.14

http://identifiers.org/biomodels.db/MODEL1310110061#_26157bf8_7e2c_47e7_b68f_c1ff560349a4
initial amount: NaN
is encoded by: hsa:3038
is: O00219
name: HAS3
boundary condition: true
initial concentration: NaN
type: Species
is: SBO:0000252
has only substance units: false
constant: false

metaM val L e
is: SBO:0000247
boundary condition: false
notes: FORMULA: C5H11NO2 CHARGE: 0 INCHI: InChI=1S/C5H11NO2/c1-3(2)4(6)5(7)8/h3-4H,6H2,1-2H3,(H,7,8)/t4-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00174
is: CHEBI:16414
type: Species
has only substance units: false
constant: false
initial amount: NaN
is: HMDB00883
initial concentration: 1.0
name: L-valine

metaR r1590
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
product: MODEL1310110061#
is described by: ECO:0000000
type: Reaction
reactant: MODEL1310110061#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
kinetic law: MODEL1310110061#
fast: false
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110061#_a2d4fb22_dfd2_43bc_9fff_93d1031a8963
constant: false
name: PYCRL
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:65263
type: Species
boundary condition: true
is: SBO:0000252
has only substance units: false
is: Q53H96

metaM HC01408 m
notes: FORMULA: C27H40N7O18P3S CHARGE: -4 INCHI: InChI=1S/C27H44N7O18P3S/c1-4-5-15(35)10-18(37)56-9-8-29-17(36)6-7-30-25(40)22(39)27(2,3)12-49-55(46,47)52-54(44,45)48-11-16-21(51-53(41,42)43)20(38)26(50-16)34-14-33-19-23(28)31-13-32-24(19)34/h13-14,16,20-22,26,38-39H,4-12H2,1-3H3,(H,29,36)(H,30,40)(H,44,45)(H,46,47)(H2,28,31,32)(H2,41,42,43)/t16-,20-,21-,22+,26-/m1/s1 EHMN_ABBREVIATION: C05269
initial amount: NaN
type: Species
boundary condition: false
is: SBO:0000247
has only substance units: false
name: 3-Oxohexanoyl-CoA
initial concentration: 1.0
constant: false
is: CHEBI:27648

metaM nrvnccoa x
boundary condition: false
is: SBO:0000247
initial amount: NaN
notes: FORMULA: C45H76N7O17P3S CHARGE: -4 INCHI: InChI=1/C45H80N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-24-25-36(54)73-29-28-47-35(53)26-27-48-43(57)40(56)45(2,3)31-66-72(63,64)69-71(61,62)65-30-34-39(68-70(58,59)60)38(55)44(67-34)52-33-51-37-41(46)49-32-50-42(37)52/h11-12,32-34,38-40,44,55-56H,4-10,13-31H2,1-3H3,(H,47,53)(H,48,57)(H,61,62)(H,63,64)(H2,46,49,50)(H2,58,59,60)/b12-11-/t34-,38-,39-,40?,44-/m1/s1
name: nervonyl coenzyme A
initial concentration: 1.0
has only substance units: false
is: C16532
constant: false
type: Species

metaR UMPK3
modifier: MODEL1310110061#
is: SBO:0000176
name: UMP kinase (UTP)
is version of: http://identifiers.org/ec-code/2.7.4.14
reversible: true
reactant: MODEL1310110061#
fast: false
product: MODEL1310110061#
type: Reaction
kinetic law: MODEL1310110061#
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:

metaM cyan c
is: SBO:0000247
initial concentration: 1.0
initial amount: NaN
has only substance units: false
is: HMDB02084
is: CHEBI:18407
constant: false
notes: FORMULA: CHN CHARGE: 0 INCHI: InChI=1S/CHN/c1-2/h1H EHMN_ABBREVIATION: C01326
type: Species
boundary condition: false
name: hydrogen cyanide

http://identifiers.org/biomodels.db/MODEL1310110061#_81ca6ca3_4dfa_4788_adad_3381b286aa27
is: GO:0005764
is: SBO:0000290
constant: false
size: 1.0
spatial dimensions: 3.0
name: lysosome
type: Compartment

metaM hdca e
is: CHEBI:0
constant: false
type: Species
boundary condition: false
has only substance units: false
is: C00249
name: Hexadecanoate (n-C16:0)
is: SBO:0000247
initial concentration: 1.0
notes: FORMULA: C16H31O2 CHARGE: -1
is: HMDB00220
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110061#_81edd53c_c002_4afe_a385_116e49a82c87
constant: false
is encoded by: hsa:2678
boundary condition: true
initial amount: NaN
is: P19440
name: GGT1
is: SBO:0000252
has only substance units: false
type: Species
initial concentration: NaN

metaR DNDPt25m
is described by: ECO:0000269
fast: false
reactant: MODEL1310110061#
notes: GENE_ASSOCIATION: (60386.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:11226231 NOTES:IT
reversible: false
is: SBO:0000185
product: MODEL1310110061#
type: Reaction
modifier: MODEL1310110061#
kinetic law: MODEL1310110061#
name: dTDP transport via dCDP antiport

metaR EX hdca LPAREN e RPAREN
kinetic law: MODEL1310110061#
reactant: MODEL1310110061#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Hexadecanoate (n-C16:0) exchange
type: Reaction

metaM docohepcoa m
has only substance units: false
notes: FORMULA: C43H60N7O17P3S CHARGE: -4
name: 2,4,7,10,13,16,19-docosaheptenoylcoa
initial amount: NaN
initial concentration: 1.0
boundary condition: false
is: HMDB02288
is: SBO:0000247
type: Species
constant: false

metaR EX leuktrD4 LPAREN e RPAREN
kinetic law: MODEL1310110061#
reactant: MODEL1310110061#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: leukotriene D4 exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110061#_456af579_b19e_4723_b2d7_a1df617f9fda
has only substance units: false
type: Species
initial concentration: NaN
boundary condition: true
is: P13196
name: ALAS1
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:211
constant: false

metaR RE0453C
name: RE0453
kinetic law: MODEL1310110061#
type: Reaction
fast: false
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Pyrimidine synthesis EC Number: 2.7.4.6 Confidence Level: 0 AUTHORS: PMID:3026468 NOTES:
reversible: true
is described by: ECO:0000000
reactant: MODEL1310110061#
product: MODEL1310110061#

metaR r1591
is: SBO:0000185
reversible: true
is described by: ECO:0000000
product: MODEL1310110061#
type: Reaction
reactant: MODEL1310110061#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
kinetic law: MODEL1310110061#

metaM ddcacoa m
initial amount: NaN
is: SBO:0000247
has only substance units: false
is: HMDB03571
is: C01832
initial concentration: 1.0
boundary condition: false
type: Species
is: CHEBI:57375
constant: false
notes: FORMULA: C33H54N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00850 EHMN_ABBREVIATION: C01832
name: Dodecanoyl-CoA (n-C12:0CoA)

metaM CE2839 e
initial amount: NaN
has only substance units: false
is: C01936
type: Species
notes: FORMULA: C60H102O51 CHARGE: 0 INCHI: InChI=1/C60H102O51/c61-1-11-21(71)22(72)33(83)52(94-11)104-43-13(3-63)96-54(35(85)24(43)74)106-45-15(5-65)98-56(37(87)26(45)76)108-47-17(7-67)100-58(39(89)28(47)78)110-49-19(9-69)102-60(41(91)30(49)80)111-50-20(10-70)101-59(40(90)31(50)81)109-48-18(8-68)99-57(38(88)29(48)79)107-46-16(6-66)97-55(36(86)27(46)77)105-44-14(4-64)95-53(34(84)25(44)75)103-42-12(2-62)93-51(92)32(82)23(42)73/h11-92H,1-10H2/t11-,12-,13-,14-,15-,16-,17-,18-,19-,20-,21+,22+,23-,24-,25-,26-,27-,28-,29-,30-,31-,32+,33+,34+,35+,36+,37+,38+,39+,40+,41+,42+,43+,44+,45+,46+,47+,48+,49+,50+,51u,52+,53+,54+,55+,56+,57+,58+,59+,60+/m1/s1 EHMN_ABBREVIATION: CE2839
constant: false
is: http://identifiers.org/pubchem.compound/5041
name: maltodecaose
boundary condition: false
initial concentration: 1.0
is: SBO:0000247

metaR LYSOXp
type: Reaction
name: L-lysine oxidase, peroxisomal
product: MODEL1310110061#
reversible: false
reactant: MODEL1310110061#
notes: GENE_ASSOCIATION: SUBSYSTEM: Lysine metabolism EC Number: 1.4.3.14 Confidence Level: 2 AUTHORS: PMID:10485319,PMID:10772957,PMID:6811962 NOTES:MM
kinetic law: MODEL1310110061#
is: SBO:0000176
is described by: ECO:0000000
fast: false

metaM thp2c c
notes: FORMULA: C6H8NO2 CHARGE: -1 INCHI: InChI=1S/C6H9NO2/c8-6(9)5-3-1-2-4-7-5/h4-5H,1-3H2,(H,8,9)/p-1 EHMN_ABBREVIATION: C00450
name: 1-piperideine-6-carboxylate
is: HMDB12130
has only substance units: false
initial concentration: 1.0
is: SBO:0000247
initial amount: NaN
boundary condition: false
is: CHEBI:16987
constant: false
type: Species

metaR UMPK4
reversible: true
reactant: MODEL1310110061#
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
modifier: MODEL1310110061#
product: MODEL1310110061#
type: Reaction
is version of: http://identifiers.org/ec-code/2.7.4.14
kinetic law: MODEL1310110061#
name: UMP kinase (GTP)
fast: false
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110061#_8f72dce9_b300_4e5e_903b_dcbb3a98b208
is: C9JZ62
constant: false
type: Species
is encoded by: hsa:641649
initial amount: NaN
has only substance units: false
boundary condition: true
is: SBO:0000252
initial concentration: NaN
name: TMEM91

metaM CE4790 m
has only substance units: false
initial concentration: 1.0
is: SBO:0000247
type: Species
notes: FORMULA: C35H56N7O18P3S CHARGE: -4 INCHI: InChI=1/C35H60N7O18P3S/c1-4-5-6-7-8-9-10-11-12-13-23(43)18-26(45)64-17-16-37-25(44)14-15-38-33(48)30(47)35(2,3)20-57-63(54,55)60-62(52,53)56-19-24-29(59-61(49,50)51)28(46)34(58-24)42-22-41-27-31(36)39-21-40-32(27)42/h8-9,21-24,28-30,34,43,46-47H,4-7,10-20H2,1-3H3,(H,37,44)(H,38,48)(H,52,53)(H,54,55)(H2,36,39,40)(H2,49,50,51)/p-4/b9-8-/t23-,24-,28+,29+,30u,34-/m0/s1 EHMN_ABBREVIATION: CE4790
initial amount: NaN
boundary condition: false
constant: false
name: (3S)-3-hydroxy-cis-8-tetradecenoyl-CoA
is: CHEBI:57923

http://identifiers.org/biomodels.db/MODEL1310110061#_18432a27_3b35_4d1c_80d3_951fbdda84f0
is encoded by: hsa:4191
has only substance units: false
type: Species
name: MDH2
is: P40926
is: SBO:0000252
constant: false
initial concentration: NaN
initial amount: NaN
boundary condition: true

metaR FAOXC185C164m
kinetic law: MODEL1310110061#
product: MODEL1310110061#
reactant: MODEL1310110061#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C18:5-->C16:4)m
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110061#_286a975c_f79a_4c08_be2a_514d33688711
initial amount: NaN
type: Species
has only substance units: false
constant: false
is encoded by: hsa:79966
is: Q86SK9
name: SCD5
initial concentration: NaN
is: SBO:0000252
boundary condition: true

metaR EX ocdca LPAREN e RPAREN
kinetic law: MODEL1310110061#
reactant: MODEL1310110061#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: echange reaction for octadecanoate (n-C18:0)
type: Reaction

metaM CE2705 c
is: SBO:0000247
boundary condition: false
has only substance units: false
is: CHEBI:52328
constant: false
type: Species
initial amount: NaN
initial concentration: 1.0
name: quinonoid dihydrobiopterin
notes: FORMULA: C9H13N5O3 CHARGE: 0 INCHI: InChI=1/C9H13N5O3/c1-3(15)6(16)4-2-11-7-5(12-4)8(17)14-9(10)13-7/h3-4,6,15-16H,2H2,1H3,(H3,10,11,13,14,17)/p+1/t3-,4?,6+/m0/s1 EHMN_ABBREVIATION: CE2705

metaR P45027A1m
is: SBO:0000176
modifier: MODEL1310110061#
reactant: MODEL1310110061#
is version of: http://identifiers.org/ec-code/1.14.13.15
type: Reaction
reversible: false
fast: false
notes: GENE_ASSOCIATION: (1593.1) SUBSYSTEM: Bile acid synthesis EC Number: Confidence Level: 4 AUTHORS: NOTES:
kinetic law: MODEL1310110061#
is described by: ECO:0000269
product: MODEL1310110061#
name: Cytochrome P450 27

http://identifiers.org/biomodels.db/MODEL1310110061#_43bfdf38_7a0a_498d_8a6a_793f8d2a55b9
constant: false
is encoded by: hsa:175
initial amount: NaN
has only substance units: false
is: SBO:0000252
name: AGA
boundary condition: true
initial concentration: NaN
type: Species
is: P20933

metaM Rtotal3 c
is: HMDB01448
name: R total 3 position
initial concentration: 1.0
has only substance units: false
is: CHEBI:16189
is: SBO:0000247
initial amount: NaN
boundary condition: false
type: Species
constant: false
notes: FORMULA: CO2FULLR3 CHARGE: -1

metaM nad x
is: CHEBI:57540
initial concentration: 1.0
is: SBO:0000247
is: http://identifiers.org/pubchem.compound/3305
name: Nicotinamide adenine dinucleotide
has only substance units: false
type: Species
constant: false
boundary condition: false
initial amount: NaN
is: HMDB00902
is: C00003

metaR r1622
reversible: true
reactant: MODEL1310110061#
kinetic law: MODEL1310110061#
type: Reaction
modifier: MODEL1310110061#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
notes: GENE_ASSOCIATION: (19.1) or (AL038231.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is described by: ECO:0000000
fast: false
is: SBO:0000185
product: MODEL1310110061#

metaM grdp x
initial amount: NaN
name: geranyl diphosphate(3-)
boundary condition: false
is: SBO:0000247
constant: false
type: Species
notes: FORMULA: C10H17O7P2 CHARGE: -3 INCHI: InChI=1S/C10H20O7P2/c1-9(2)5-4-6-10(3)7-8-16-19(14,15)17-18(11,12)13/h5,7H,4,6,8H2,1-3H3,(H,14,15)(H2,11,12,13)/p-3/b10-7+ HEPATONET_1.0_ABBREVIATION: HC00288 EHMN_ABBREVIATION: C00341
is: CHEBI:58057
initial concentration: 1.0
is: HMDB01285
has only substance units: false

metaR r0839
fast: false
is described by: ECO:0000000
is: SBO:0000185
product: MODEL1310110061#
type: Reaction
kinetic law: MODEL1310110061#
reversible: true
is version of: http://identifiers.org/ec-code/1.3.1.70
notes: GENE_ASSOCIATION: (7108.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:7419607 NOTES:
reactant: MODEL1310110061#
name: Postulated transport reaction
modifier: MODEL1310110061#

metaR L LACt4r
kinetic law: MODEL1310110061#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:8476015,PMID:9425115 NOTES:
name: L-lactate reversible transport via sodium symport
product: MODEL1310110061#
type: Reaction
is described by: ECO:0000000
reversible: true
is: SBO:0000185
reactant: MODEL1310110061#
fast: false

metaR r0838
reversible: true
notes: GENE_ASSOCIATION: (26275.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:3888072 NOTES:
fast: false
reactant: MODEL1310110061#
is: SBO:0000185
kinetic law: MODEL1310110061#
name: Free diffusion
is version of: http://identifiers.org/ec-code/3.1.2.4
product: MODEL1310110061#
modifier: MODEL1310110061#
type: Reaction
is described by: ECO:0000000

metaR BACCLm
kinetic law: MODEL1310110061#
is version of: http://identifiers.org/ec-code/6.3.4.10
type: Reaction
is described by: ECO:0000254
name: biotin-[acetyl-CoA-carboxylase] ligase, mitochondrial
reversible: false
fast: false
notes: GENE_ASSOCIATION: (3141.1) SUBSYSTEM: Biotin metabolism EC Number: 6.3.4.15 Confidence Level: 2 AUTHORS: PMID:12459313,PMID:7842009 NOTES:IT
product: MODEL1310110061#
is: SBO:0000176
reactant: MODEL1310110061#
modifier: MODEL1310110061#

http://identifiers.org/biomodels.db/MODEL1310110061#_a898b5cf_65bc_45f0_a519_0f588260b1ff
name: ACSL4
boundary condition: true
is: O60488
is: SBO:0000252
constant: false
has only substance units: false
initial concentration: NaN
is encoded by: hsa:2182
type: Species
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110061#_d740175d_d8fd_4fb2_a0ac_5f0a3638922d
name: SLC2A9
type: Species
boundary condition: true
is: SBO:0000252
initial concentration: NaN
has only substance units: false
initial amount: NaN
is encoded by: hsa:56606
constant: false

metaR O2St
name: superoxide anion transport via diffusion (extracellular)
product: MODEL1310110061#
reversible: true
is described by: ECO:0000000
is: SBO:0000185
reactant: MODEL1310110061#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:12939409 NOTES:
type: Reaction
fast: false
kinetic law: MODEL1310110061#

metaM udpg r
constant: false
initial amount: NaN
type: Species
is: CHEBI:58367
notes: FORMULA: C15H22N2O17P2 CHARGE: -2 INCHI: InChI=1S/C15H24N2O17P2/c18-3-5-8(20)10(22)12(24)14(32-5)33-36(28,29)34-35(26,27)30-4-6-9(21)11(23)13(31-6)17-2-1-7(19)16-15(17)25/h1-2,5-6,8-14,18,20-24H,3-4H2,(H,26,27)(H,28,29)(H,16,19,25)/p-2/t5-,6-,8-,9-,10+,11-,12-,13-,14?/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00038 EHMN_ABBREVIATION: C00029
is: SBO:0000247
has only substance units: false
name: [(2R,3S,4R,5R)-5-(2,4-dioxo-1,2,3,4-tetrahydropyrimidin-1-yl)-3,4-dihydroxyoxolan-2-yl]methyl {[(3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl phosphonato]oxy}phosphonate
initial concentration: 1.0
boundary condition: false
is: HMDB00286

http://identifiers.org/biomodels.db/MODEL1310110061#_ec2a406f_787b_4fd1_853a_72309b79f32a
has only substance units: false
boundary condition: true
name: OCRL
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:4952
type: Species
is: SBO:0000252
constant: false

http://identifiers.org/biomodels.db/MODEL1310110061#_cf281c0b_943c_4621_9c7a_4060ea2f6e6c
is encoded by: hsa:2109
has part: P38117
boundary condition: true
type: Species
constant: false
name: ETFA:ETFB
has only substance units: false
is: SBO:0000297
initial amount: NaN
initial concentration: NaN

metaM ddcacoa c
is: C01832
is: CHEBI:57375
has only substance units: false
constant: false
type: Species
notes: FORMULA: C33H54N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00850 EHMN_ABBREVIATION: C01832
initial amount: NaN
is: HMDB03571
boundary condition: false
initial concentration: 1.0
name: Dodecanoyl-CoA (n-C12:0CoA)
is: SBO:0000247

metaR ALAASNNaEx
kinetic law: MODEL1310110061#
is: SBO:0000185
name: L-alanine/L-asparagine Na-dependent exchange (Ala-L in)
reactant: MODEL1310110061#
reversible: false
fast: false
type: Reaction
modifier: MODEL1310110061#
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (6510.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14530974 NOTES:SAB see Kanai and Hediger 2004 (2003), PMID 14530974
product: MODEL1310110061#

metaR r2141
reactant: MODEL1310110061#
product: MODEL1310110061#
is: SBO:0000185
fast: false
kinetic law: MODEL1310110061#
modifier: MODEL1310110061#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.14
reversible: true
type: Reaction
is described by: ECO:0000000

metaR r1847
reversible: false
type: Reaction
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
kinetic law: MODEL1310110061#
reactant: MODEL1310110061#
fast: false
is described by: ECO:0000000
is: SBO:0000185
name: Y+LAT2 Utilized transport
modifier: MODEL1310110061#
product: MODEL1310110061#

metaR r1621
product: MODEL1310110061#
reversible: true
fast: false
reactant: MODEL1310110061#
kinetic law: MODEL1310110061#
type: Reaction
is described by: ECO:0000000
is: SBO:0000185
modifier: MODEL1310110061#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
notes: GENE_ASSOCIATION: (19.1) or (AL038231.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:

metaR MI134PP
is described by: ECO:0000269
product: MODEL1310110061#
notes: GENE_ASSOCIATION: (3628.1) SUBSYSTEM: Inositol phosphate metabolism EC Number: 3.1.3.61 Confidence Level: 4 AUTHORS: PMID:2906139,PMID:8390685 NOTES:NCD
name: inositol-1,3,4-trisphosphate 1-phosphatase
is version of: http://identifiers.org/ec-code/3.1.3.57
is: SBO:0000176
reversible: false
modifier: MODEL1310110061#
reactant: MODEL1310110061#
kinetic law: MODEL1310110061#
fast: false
type: Reaction

metaM prpp c
notes: FORMULA: C5H8O14P3 CHARGE: -5 HEPATONET_1.0_ABBREVIATION: HC00117 EHMN_ABBREVIATION: C00119
name: 5-Phospho-alpha-D-ribose 1-diphosphate
initial amount: NaN
is: SBO:0000247
constant: false
type: Species
boundary condition: false
initial concentration: 1.0
has only substance units: false
is: CHEBI:58017
is: HMDB00280
is: C00119

metaM CE2421 m
constant: false
is: CHEBI:30623
notes: FORMULA: C39H62N7O18P3S CHARGE: -4 INCHI: InChI=1/C39H66N7O18P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-27(47)22-30(49)68-21-20-41-29(48)18-19-42-37(52)34(51)39(2,3)24-61-67(58,59)64-66(56,57)60-23-28-33(63-65(53,54)55)32(50)38(62-28)46-26-45-31-35(40)43-25-44-36(31)46/h8-9,11-12,25-28,32-34,38,47,50-51H,4-7,10,13-24H2,1-3H3,(H,41,48)(H,42,52)(H,56,57)(H,58,59)(H2,40,43,44)(H2,53,54,55)/p-4/b9-8-,12-11-/t27-,28-,32+,33+,34u,38-/m0/s1 EHMN_ABBREVIATION: CE2421
boundary condition: false
type: Species
initial amount: NaN
has only substance units: false
name: (3S)-3-hydroxylinoleoyl-CoA
initial concentration: 1.0
is: HMDB02329
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110061#_32070327_5445_4d0e_b573_941b676e4ef0
is encoded by: hsa:6513
has only substance units: false
boundary condition: true
name: SLC2A1
type: Species
initial amount: NaN
constant: false
initial concentration: NaN
is: SBO:0000252
is: P11166

metaM urea e
has only substance units: false
initial amount: NaN
is: SBO:0000247
boundary condition: false
type: Species
is: C00086
is: HMDB00294
initial concentration: 1.0
notes: FORMULA: CH4N2O CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00089 EHMN_ABBREVIATION: C00086
constant: false
is: CHEBI:16199
name: Urea

metaM hexc e
is: SBO:0000247
is: CHEBI:31013
notes: FORMULA: C26H51O2 CHARGE: -1 INCHI: InChI=1S/C26H52O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-24-25-26(27)28/h2-25H2,1H3,(H,27,28)/p-1
constant: false
initial amount: NaN
type: Species
has only substance units: false
name: cerotate
initial concentration: 1.0
boundary condition: false
is: HMDB02356

http://identifiers.org/biomodels.db/MODEL1310110061#_7260846a_3907_45af_8373_7170faabe336
constant: false
type: Species
name: DGKI
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:9162
boundary condition: true
has only substance units: false
is: O75912
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110061#_9f70ef0a_981c_4f9c_a9f1_3c6b0d52230b
type: Species
name: PTGIS
is encoded by: hsa:5740
is: SBO:0000252
constant: false
is: Q16647
boundary condition: true
initial concentration: NaN
initial amount: NaN
has only substance units: false

metaR r0993
reversible: false
is: SBO:0000185
kinetic law: MODEL1310110061#
product: MODEL1310110061#
reactant: MODEL1310110061#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14716480,PMID:15209530,PMID:15297262 NOTES:
name: ATP-binding Cassette (ABC) TCDB:3.A.1.208.2
is described by: ECO:0000000
type: Reaction
fast: false

metaM dha e
initial amount: NaN
boundary condition: false
name: glycerone
is: HMDB01882
type: Species
is: CHEBI:16016
constant: false
notes: FORMULA: C3H6O3 CHARGE: 0 INCHI: InChI=1S/C3H6O3/c4-1-3(6)2-5/h4-5H,1-2H2 HEPATONET_1.0_ABBREVIATION: HC00175 EHMN_ABBREVIATION: C00184
initial concentration: 1.0
is: SBO:0000247
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110061#_dc3bff4f_7197_461e_b253_3757e7656223
initial amount: NaN
name: DCK
has only substance units: false
is: SBO:0000252
is: P27707
type: Species
boundary condition: true
is encoded by: hsa:1633
initial concentration: NaN
constant: false

metaR r2140
reactant: MODEL1310110061#
kinetic law: MODEL1310110061#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.14
reversible: true
is: SBO:0000185
type: Reaction
is described by: ECO:0000000
modifier: MODEL1310110061#
fast: false
product: MODEL1310110061#

metaM hyptaur c
constant: false
notes: FORMULA: C2H7NO2S CHARGE: 0 INCHI: InChI=1S/C2H7NO2S/c3-1-2-6(4)5/h1-3H2,(H,4,5) HEPATONET_1.0_ABBREVIATION: HC00406 EHMN_ABBREVIATION: C00519
is: HMDB00965
boundary condition: false
name: Hypotaurine
initial concentration: 1.0
is: SBO:0000247
initial amount: NaN
has only substance units: false
type: Species
is: CHEBI:16668

metaM ocdcea e
type: Species
is: CHEBI:0
initial concentration: 1.0
notes: FORMULA: C18H33O2 CHARGE: -1
is: SBO:0000247
has only substance units: false
initial amount: NaN
name: octadecenoate (n-C18:1)
boundary condition: false
is: C00712
is: HMDB00207
constant: false

metaM f6p c
type: Species
is: CHEBI:57579
is: HMDB00124
has only substance units: false
name: D-Fructose 6-phosphate
initial amount: NaN
is: SBO:0000247
is: http://identifiers.org/pubchem.compound/3385
constant: false
is: C00085
boundary condition: false
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110061#_bc8a0807_bf17_4ec0_8c55_6519e4ae7a71
is: P48735
initial concentration: NaN
has only substance units: false
is: SBO:0000252
boundary condition: true
constant: false
initial amount: NaN
type: Species
is encoded by: hsa:3418
name: IDH2

http://identifiers.org/biomodels.db/MODEL1310110061#_8a19400b_e694_4a65_8e34_d18fa8a4690b
type: Species
has only substance units: false
constant: false
initial amount: NaN
name: HMGCS2
is encoded by: hsa:3158
is: P54868
is: SBO:0000252
boundary condition: true
initial concentration: NaN

metaR r1624
is described by: ECO:0000000
fast: false
kinetic law: MODEL1310110061#
notes: GENE_ASSOCIATION: (19.1) or (AL038231.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
product: MODEL1310110061#
is: SBO:0000185
modifier: MODEL1310110061#
reversible: true
reactant: MODEL1310110061#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
type: Reaction

metaM Rtotal3 e
notes: FORMULA: CO2FULLR3 CHARGE: -1
is: HMDB00244
is: CHEBI:3554
initial concentration: 1.0
name: R total 3 position
is: C00255
is: SBO:0000247
initial amount: NaN
has only substance units: false
constant: false
type: Species
boundary condition: false

metaR PI345P3P
reversible: false
notes: GENE_ASSOCIATION: (5728.1) SUBSYSTEM: Inositol phosphate metabolism EC Number: 3.1.3.67 Confidence Level: 4 AUTHORS: PMID:11463863 NOTES:NCD
modifier: MODEL1310110061#
name: phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase
type: Reaction
kinetic law: MODEL1310110061#
product: MODEL1310110061#
reactant: MODEL1310110061#
is version of: http://identifiers.org/ec-code/3.1.3.67
is: SBO:0000176
is described by: ECO:0000000
fast: false

metaM HC02203 c
name: prostaglandin-a2
notes: FORMULA: C20H29O4 CHARGE: -1 INCHI: InChI=1S/C20H30O4/c1-2-3-6-9-17(21)14-12-16-13-15-19(22)18(16)10-7-4-5-8-11-20(23)24/h4,7,12-18,21H,2-3,5-6,8-11H2,1H3,(H,23,24)/b7-4-,14-12+/t16-,17-,18+/m0/s1 EHMN_ABBREVIATION: C05953
initial concentration: 1.0
boundary condition: false
has only substance units: false
type: Species
is: CHEBI:27820
initial amount: NaN
is: SBO:0000247
constant: false

metaR GBA
name: Glucosylceramidase
is described by: ECO:0000000
product: MODEL1310110061#
reversible: false
fast: false
type: Reaction
is version of: http://identifiers.org/ec-code/3.2.1.45
notes: GENE_ASSOCIATION: (2629.2) or (2629.3) or (2629.4) or (2629.5) or (2629.1) SUBSYSTEM: Sphingolipid metabolism EC Number: 3.2.1.45 Confidence Level: 0 AUTHORS: PMID:15982918 NOTES:NJ
reactant: MODEL1310110061#
kinetic law: MODEL1310110061#
modifier: MODEL1310110061#
is: SBO:0000176

metaM 34dhmald m
initial amount: NaN
initial concentration: 1.0
is: SBO:0000247
is: http://identifiers.org/pubchem.compound/7903
notes: FORMULA: C8H8O4 CHARGE: 0 INCHI: InChI=1/C8H8O4/c9-4-8(12)5-1-2-6(10)7(11)3-5/h1-4,8,10-12H HEPATONET_1.0_ABBREVIATION: HC01514 EHMN_ABBREVIATION: C05577
boundary condition: false
is: C05577
constant: false
has only substance units: false
is: HMDB06242
name: 3,4-Dihydroxymandelaldehyde
type: Species

http://identifiers.org/biomodels.db/MODEL1310110061#_223b7fd7_68a7_42fb_a618_26fcd7eff1dc
initial amount: NaN
type: Species
is encoded by: hsa:AA629629
is: SBO:0000252
boundary condition: true
name: _AA629629_1_m
has only substance units: false
constant: false
initial concentration: NaN

metaR CITtam
is: SBO:0000185
fast: false
product: MODEL1310110061#
notes: GENE_ASSOCIATION: (6576.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172 NOTES:antiport with malate IF
name: citrate transport, mitochondrial
reversible: true
modifier: MODEL1310110061#
reactant: MODEL1310110061#
kinetic law: MODEL1310110061#
type: Reaction
is described by: ECO:0000269

metaM 4mop c
has only substance units: false
initial amount: NaN
type: Species
is: CHEBI:17865
boundary condition: false
notes: FORMULA: C6H9O3 CHARGE: -1 INCHI: InChI=1S/C6H10O3/c1-4(2)3-5(7)6(8)9/h4H,3H2,1-2H3,(H,8,9)/p-1 HEPATONET_1.0_ABBREVIATION: HC00211 EHMN_ABBREVIATION: C00233
initial concentration: 1.0
constant: false
is: HMDB00695
name: 4-methyl-2-oxopentanoate
is: SBO:0000247

metaM oaa m
initial amount: NaN
is: SBO:0000247
constant: false
is: CHEBI:16452
is: C00036
initial concentration: 1.0
is: HMDB00223
boundary condition: false
type: Species
has only substance units: false
name: Oxaloacetate
notes: FORMULA: C4H2O5 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00044 EHMN_ABBREVIATION: C00036

metaM CE2432 m
is: SBO:0000247
initial concentration: 1.0
has only substance units: false
notes: FORMULA: C35H52N7O17P3S CHARGE: -4 INCHI: InChI=1/C35H56N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-26(44)63-19-18-37-25(43)16-17-38-33(47)30(46)35(2,3)21-56-62(53,54)59-61(51,52)55-20-24-29(58-60(48,49)50)28(45)34(57-24)42-23-41-27-31(36)39-22-40-32(27)42/h8-9,11-12,14-15,22-24,28-30,34,45-46H,4-7,10,13,16-21H2,1-3H3,(H,37,43)(H,38,47)(H,51,52)(H,53,54)(H2,36,39,40)(H2,48,49,50)/p-4/b9-8-,12-11-,15-14+/t24-,28+,29+,30u,34-/m0/s1 EHMN_ABBREVIATION: CE2432
initial amount: NaN
type: Species
name: trans-2-cis,cis-5,8-tetradecatrienoyl-CoA
constant: false
is: CHEBI:57795
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110061#_a112cb4a_bded_45cd_87e1_c1e272650e0f
boundary condition: true
name: _AI971036_1_m
type: Species
initial amount: NaN
constant: false
initial concentration: NaN
is encoded by: hsa:AI971036
has only substance units: false
is: SBO:0000252

metaR SERPT
notes: GENE_ASSOCIATION: (10558.1 and 9517.1) SUBSYSTEM: Sphingolipid metabolism EC Number: 2.3.1.50 Confidence Level: 4 AUTHORS: NOTES:NCD
reversible: false
fast: false
product: MODEL1310110061#
is described by: ECO:0000269
modifier: MODEL1310110061#
name: serine C-palmitoyltransferase
kinetic law: MODEL1310110061#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.3.1.50
reactant: MODEL1310110061#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110061#_49a58b6e_17cf_4668_9e35_ea70af6f5d48
is: SBO:0000252
constant: false
type: Species
initial concentration: NaN
is encoded by: hsa:221823
name: PRPS1L1
has only substance units: false
initial amount: NaN
boundary condition: true

metaR r0836
type: Reaction
is described by: ECO:0000000
reversible: true
notes: GENE_ASSOCIATION: (2643.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:10585886,PMID:14598172,PMID:4424886,PMID:4441366,PMID:5099217,PMID:8329439 NOTES:
fast: false
reactant: MODEL1310110061#
kinetic law: MODEL1310110061#
name: Mitochondrial Carrier (MC) TCDB:2.A.29.2.2
product: MODEL1310110061#
is: SBO:0000185
modifier: MODEL1310110061#
is version of: http://identifiers.org/ec-code/3.5.4.16

metaR r1921
is described by: ECO:0000000
is: SBO:0000185
fast: false
reversible: false
product: MODEL1310110061#
reactant: MODEL1310110061#
type: Reaction
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
name: Y+LAT2 Utilized transport
kinetic law: MODEL1310110061#
modifier: MODEL1310110061#

metaR r0994
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:15975683 NOTES:
reversible: true
name: Facilitated diffusion
fast: false
kinetic law: MODEL1310110061#
reactant: MODEL1310110061#
is described by: ECO:0000000
is: SBO:0000185
product: MODEL1310110061#

metaM cholcoa x
initial amount: NaN
notes: FORMULA: C45H70N7O20P3S CHARGE: -4 INCHI: InChI=1S/C45H74N7O20P3S/c1-23(26-7-8-27-34-28(18-31(55)45(26,27)5)44(4)12-10-25(53)16-24(44)17-29(34)54)6-9-33(57)76-15-14-47-32(56)11-13-48-41(60)38(59)43(2,3)20-69-75(66,67)72-74(64,65)68-19-30-37(71-73(61,62)63)36(58)42(70-30)52-22-51-35-39(46)49-21-50-40(35)52/h21-31,34,36-38,42,53-55,58-59H,6-20H2,1-5H3,(H,47,56)(H,48,60)(H,64,65)(H,66,67)(H2,46,49,50)(H2,61,62,63)/p-4/t23-,24+,25-,26-,27+,28+,29-,30-,31+,34+,36-,37-,38+,42-,44+,45-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00844 EHMN_ABBREVIATION: C01794
has only substance units: false
constant: false
is: CHEBI:57373
is: HMDB01374
boundary condition: false
name: choloyl-CoA(4-)
type: Species
is: SBO:0000247
initial concentration: 1.0

metaR DM Asn X Ser Thr ly
kinetic law: MODEL1310110061#
reactant: MODEL1310110061#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 0 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: false
name: DM Asn-X-Ser/Thr(ly)
type: Reaction

metaR EX gal LPAREN e RPAREN
kinetic law: MODEL1310110061#
reactant: MODEL1310110061#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for D-Galactose
type: Reaction

metaM thr L c
has only substance units: false
type: Species
initial amount: NaN
name: L-threonine
constant: false
initial concentration: 1.0
is: HMDB00167
boundary condition: false
is: CHEBI:16857
is: SBO:0000247
notes: FORMULA: C4H9NO3 CHARGE: 0 INCHI: InChI=1S/C4H9NO3/c1-2(6)3(5)4(7)8/h2-3,6H,5H2,1H3,(H,7,8)/t2-,3+/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00179

metaM arachcoa c
has only substance units: false
is: HMDB04258
notes: FORMULA: C41H70N7O17P3S CHARGE: -4 INCHI: InChI=1S/C41H74N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-32(50)69-25-24-43-31(49)22-23-44-39(53)36(52)41(2,3)27-62-68(59,60)65-67(57,58)61-26-30-35(64-66(54,55)56)34(51)40(63-30)48-29-47-33-37(42)45-28-46-38(33)48/h28-30,34-36,40,51-52H,4-27H2,1-3H3,(H,43,49)(H,44,53)(H,57,58)(H,59,60)(H2,42,45,46)(H2,54,55,56)/t30-,34-,35-,36+,40-/m1/s1 EHMN_ABBREVIATION: C02041
is: SBO:0000247
boundary condition: false
initial concentration: 1.0
constant: false
is: CHEBI:15527
name: arachidyl coenzyme A
type: Species
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110061#_eb64c946_2fca_4e3c_9113_a2982203894b
boundary condition: true
constant: false
is: SBO:0000252
initial concentration: NaN
has only substance units: false
name: SLC24A1
initial amount: NaN
is encoded by: hsa:9187
is: B4DUG1
type: Species

metaR r1623
notes: GENE_ASSOCIATION: (19.1) or (AL038231.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reactant: MODEL1310110061#
is: SBO:0000185
type: Reaction
is described by: ECO:0000000
modifier: MODEL1310110061#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
kinetic law: MODEL1310110061#
product: MODEL1310110061#
fast: false
reversible: true

metaM ibcoa m
has only substance units: false
is: CHEBI:57338
constant: false
type: Species
initial amount: NaN
is: HMDB01243
notes: FORMULA: C25H38N7O17P3S CHARGE: -4 INCHI: InChI=1S/C25H42N7O17P3S/c1-13(2)24(37)53-8-7-27-15(33)5-6-28-22(36)19(35)25(3,4)10-46-52(43,44)49-51(41,42)45-9-14-18(48-50(38,39)40)17(34)23(47-14)32-12-31-16-20(26)29-11-30-21(16)32/h11-14,17-19,23,34-35H,5-10H2,1-4H3,(H,27,33)(H,28,36)(H,41,42)(H,43,44)(H2,26,29,30)(H2,38,39,40)/p-4/t14-,17-,18-,19+,23-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00462 EHMN_ABBREVIATION: C00630
name: isobutyryl-CoA(4-)
boundary condition: false
initial concentration: 1.0
is: SBO:0000247

metaR DOLPMT4 Ler
fast: false
name: dolichyl-phosphate-mannose-glycolipid alpha-mannosyltransferase (liver)
kinetic law: MODEL1310110061#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: N-glycan synthesis EC Number: 2.4.1.130 Confidence Level: 0 AUTHORS: NOTES:
product: MODEL1310110061#
is: SBO:0000185
reversible: false
type: Reaction
reactant: MODEL1310110061#

http://identifiers.org/biomodels.db/MODEL1310110061#_27f9354a_12dc_4c40_a8ca_cbb37a973d48
initial amount: NaN
is: SBO:0000252
initial concentration: NaN
boundary condition: true
constant: false
is encoded by: hsa:AI653169
has only substance units: false
type: Species
name: _AI653169_1_c

http://identifiers.org/biomodels.db/MODEL1310110061#_f1b45228_cdec_4b1d_9bf3_02211eb157c9
constant: false
initial amount: NaN
type: Species
name: ATG9B
has only substance units: false
boundary condition: true
is: Q674R7
is: SBO:0000252
is encoded by: hsa:285973
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110061#_faaa335c_3006_41eb_9a88_5d7ca1b438ed
name: COX3
boundary condition: true
initial concentration: NaN
has only substance units: false
is encoded by: hsa:4514
constant: false
type: Species
initial amount: NaN
is: SBO:0000252
is: P00414

metaR r1018
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:10884298,PMID:6469982 NOTES:
is described by: ECO:0000000
kinetic law: MODEL1310110061#
name: Transport reaction
product: MODEL1310110061#
type: Reaction
is: SBO:0000185
reactant: MODEL1310110061#
reversible: true

metaR MANt4
notes: GENE_ASSOCIATION: (200010.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12748858,PMID:15607332 NOTES:NCD
reactant: MODEL1310110061#
kinetic law: MODEL1310110061#
name: D-mannose transport via sodium cotransport
type: Reaction
product: MODEL1310110061#
is: SBO:0000185
is described by: ECO:0000269
modifier: MODEL1310110061#
fast: false
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110061#_a91d202d_3b5f_4ffc_ab29_0229eb41c446
is: SBO:0000252
constant: false
initial concentration: NaN
is encoded by: hsa:1103
initial amount: NaN
type: Species
is: P28329
has only substance units: false
name: CHAT
boundary condition: true

metaR r0835
fast: false
name: Mitochondrial Carrier (MC) TCDB:2.A.29.2.2
type: Reaction
is described by: ECO:0000000
is: SBO:0000185
reversible: true
notes: GENE_ASSOCIATION: (2643.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:10585886,PMID:14598172,PMID:4424886,PMID:4441366,PMID:5099217,PMID:8329439 NOTES:
modifier: MODEL1310110061#
is version of: http://identifiers.org/ec-code/3.5.4.16
reactant: MODEL1310110061#
kinetic law: MODEL1310110061#
product: MODEL1310110061#

metaM ocdcea c
boundary condition: false
is: SBO:0000247
name: octadecenoate (n-C18:1)
initial concentration: 1.0
is: CHEBI:0
constant: false
is: HMDB00207
type: Species
notes: FORMULA: C18H33O2 CHARGE: -1
initial amount: NaN
is: C00712
has only substance units: false

metaR VACCt
fast: false
is described by: ECO:0000000
is: SBO:0000185
reversible: true
type: Reaction
name: fatty acid transport via diffusion
kinetic law: MODEL1310110061#
product: MODEL1310110061#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11788354,PMID:12864740 NOTES:NJ
reactant: MODEL1310110061#

http://identifiers.org/biomodels.db/MODEL1310110061#_4b2c6326_cf8a_4900_b354_ebcc9568f4ce
is encoded by: hsa:768
has only substance units: false
name: CA9
boundary condition: true
initial amount: NaN
initial concentration: NaN
type: Species
is: Q16790
constant: false
is: SBO:0000252

metaM pail5p hs c
notes: FORMULA: C9H15O12P2FULLRCO2FULLR2CO2 CHARGE: -3
has only substance units: false
initial concentration: 1.0
boundary condition: false
is: SBO:0000247
initial amount: NaN
type: Species
name: 1-phosphatidyl-1D-myo-inositol 5-phosphate(3-)
is: CHEBI:57795
constant: false

metaM acn13acngalgbside hs c
is: HMDB00223
name: sialyl (1,3) sialyl (2,6) galactosylgloboside
notes: FORMULA: C72H121N4O43FULLRCO CHARGE: -2
is: C00036
initial amount: NaN
is: SBO:0000247
has only substance units: false
type: Species
boundary condition: false
is: CHEBI:3338
constant: false
initial concentration: 1.0

metaM hyptaur e
is: HMDB00965
boundary condition: false
is: SBO:0000247
initial amount: NaN
notes: FORMULA: C2H7NO2S CHARGE: 0 INCHI: InChI=1S/C2H7NO2S/c3-1-2-6(4)5/h1-3H2,(H,4,5)
name: Hypotaurine
initial concentration: 1.0
constant: false
type: Species
is: CHEBI:16668
has only substance units: false

metaR r2142
reactant: MODEL1310110061#
product: MODEL1310110061#
kinetic law: MODEL1310110061#
is: SBO:0000185
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
reversible: true
type: Reaction
is described by: ECO:0000000
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.14
fast: false
modifier: MODEL1310110061#

http://identifiers.org/biomodels.db/MODEL1310110061#_85614e1b_dd44_4483_82b3_30556febcc54
constant: false
name: TM7SF2
boundary condition: true
initial concentration: NaN
is: SBO:0000252
is: O76062
is encoded by: hsa:7108
type: Species
has only substance units: false
initial amount: NaN

metaR RE2972M
reversible: true
kinetic law: MODEL1310110061#
is version of: http://identifiers.org/ec-code/2.7.1.67
reactant: MODEL1310110061#
is described by: ECO:0000000
modifier: MODEL1310110061#
notes: GENE_ASSOCIATION: (5297.1) or (5298.1) SUBSYSTEM: Phosphatidylinositol phosphate metabolism EC Number: 2.7.1.67 Confidence Level: 0 AUTHORS: PMID:10358929,PMID:11493657,PMID:7961848,PMID:9211928 NOTES:
type: Reaction
product: MODEL1310110061#
fast: false
is: SBO:0000176
name: RE2972

http://identifiers.org/biomodels.db/MODEL1310110061#_181b3492_8d76_41b2_acb2_b2809db22ad0
constant: false
type: Species
initial concentration: NaN
is: SBO:0000252
initial amount: NaN
is: Q9HBH5
has only substance units: false
name: RDH14
boundary condition: true
is encoded by: hsa:57665

http://identifiers.org/biomodels.db/MODEL1310110061#_2ec45304_ed0f_4152_b0f5_e72758a80c4a
has only substance units: false
constant: false
initial concentration: NaN
is: O75874
is: SBO:0000252
is encoded by: hsa:3417
initial amount: NaN
name: IDH1
type: Species
boundary condition: true

metaR CLOHtex2
is described by: ECO:0000304
is: SBO:0000185
reactant: MODEL1310110061#
name: chloride transport via hydroxide countertransport (2:1)
kinetic law: MODEL1310110061#
notes: GENE_ASSOCIATION: (65010.1) or (65010.3) or (65010.2) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:12759755 NOTES:SAB
reversible: false
type: Reaction
product: MODEL1310110061#
fast: false
modifier: MODEL1310110061#

metaR 4MOPte
is: SBO:0000185
kinetic law: MODEL1310110061#
fast: false
product: MODEL1310110061#
reactant: MODEL1310110061#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
name: Transport of 4-methyl-2-oxopentanoate
is described by: ECO:0000134
reversible: true

metaM acngalgbside hs g
constant: false
initial concentration: 1.0
notes: FORMULA: C61H105N3O35FULLRCO CHARGE: -1
name: sialyl galactosylgloboside
has only substance units: false
initial amount: NaN
boundary condition: false
is: CHEBI:16523
type: Species
is: HMDB03406
is: SBO:0000247

metaM HC02203 e
notes: FORMULA: C20H29O4 CHARGE: -1 INCHI: InChI=1S/C20H30O4/c1-2-3-6-9-17(21)14-12-16-13-15-19(22)18(16)10-7-4-5-8-11-20(23)24/h4,7,12-18,21H,2-3,5-6,8-11H2,1H3,(H,23,24)/b7-4-,14-12+/t16-,17-,18+/m0/s1 EHMN_ABBREVIATION: C05953
has only substance units: false
name: prostaglandin-a2
boundary condition: false
constant: false
initial amount: NaN
is: SBO:0000247
initial concentration: 1.0
type: Species
is: CHEBI:27820

http://identifiers.org/biomodels.db/MODEL1310110061#_43eb7a16_6032_4d96_8413_359fa2e081f6
is: SBO:0000252
boundary condition: true
constant: false
is encoded by: hsa:83549
has only substance units: false
type: Species
name: UCK1
initial concentration: NaN
is: Q5JT09
initial amount: NaN

metaM 4mop e
is: SBO:0000247
has only substance units: false
boundary condition: false
constant: false
is: HMDB00695
notes: FORMULA: C6H9O3 CHARGE: -1 INCHI: InChI=1S/C6H10O3/c1-4(2)3-5(7)6(8)9/h4H,3H2,1-2H3,(H,8,9)/p-1
name: 4-methyl-2-oxopentanoate
type: Species
initial concentration: 1.0
is: CHEBI:17865
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110061#_2e5c7443_febc_4fcc_a795_c8b73cba2880
boundary condition: true
constant: false
is: Q9NQ66
type: Species
is encoded by: hsa:23236
is: SBO:0000252
name: PLCB1
initial concentration: NaN
initial amount: NaN
has only substance units: false

metaM gly e
is: HMDB00123
is: SBO:0000247
type: Species
is: CHEBI:3339
boundary condition: false
has only substance units: false
notes: FORMULA: C2H5NO2 CHARGE: 0
constant: false
name: Glycine
initial concentration: 1.0
is: C00037
initial amount: NaN

metaR FACOAL246 1
kinetic law: MODEL1310110061#
fast: false
reactant: MODEL1310110061#
is version of: http://identifiers.org/ec-code/6.2.1.3
type: Reaction
product: MODEL1310110061#
is: SBO:0000176
reversible: true
is described by: ECO:0000000
modifier: MODEL1310110061#
notes: GENE_ASSOCIATION: (2180.1) SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 4 AUTHORS: PMID:15292367 NOTES:NJ
name: fatty-acid--CoA ligase

metaM amet c
initial amount: NaN
constant: false
is: CHEBI:15414
notes: FORMULA: C15H23N6O5S CHARGE: 1 HEPATONET_1.0_ABBREVIATION: HC00029 EHMN_ABBREVIATION: C00019
type: Species
is: HMDB01185
boundary condition: false
initial concentration: 1.0
is: C00019
name: S-Adenosyl-L-methionine
has only substance units: false
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110061#_ef110f83_3a73_408d_9bba_e7024997543f
is: B2RDZ2
type: Species
initial amount: NaN
is encoded by: hsa:55312
initial concentration: NaN
name: RFK
has only substance units: false
is: SBO:0000252
constant: false
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110061#_4cebf4ca_6b21_426c_9653_5534061bcac6
initial amount: NaN
boundary condition: true
is: SBO:0000252
type: Species
is encoded by: hsa:1718
constant: false
name: DHCR24
initial concentration: NaN
is: Q15392
has only substance units: false

metaR MAN6PI
kinetic law: MODEL1310110061#
fast: false
product: MODEL1310110061#
notes: GENE_ASSOCIATION: (4351.1) SUBSYSTEM: Fructose and mannose metabolism EC Number: 5.3.1.8 Confidence Level: 2 AUTHORS: NOTES:
is: SBO:0000176
modifier: MODEL1310110061#
is version of: http://identifiers.org/ec-code/5.3.1.8
is described by: ECO:0000304
name: mannose-6-phosphate isomerase
reversible: true
type: Reaction
reactant: MODEL1310110061#

http://identifiers.org/biomodels.db/MODEL1310110061#_a4a2bb62_e25c_4972_824c_be01e2677648
initial concentration: NaN
boundary condition: true
initial amount: NaN
constant: false
is: P18405
is encoded by: hsa:6715
type: Species
is: SBO:0000252
name: SRD5A1
has only substance units: false

metaR r2073
kinetic law: MODEL1310110061#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14530970 NOTES:
type: Reaction
reversible: false
fast: false
product: MODEL1310110061#
modifier: MODEL1310110061#
name: Zinc (Zn2+)-Iron (Fe2+) Permease (ZIP), TCDB:2.A.55.2.3
is: SBO:0000185
reactant: MODEL1310110061#

http://identifiers.org/biomodels.db/MODEL1310110061#_25a5af82_3cbd_4121_b5eb_f255965117c8
constant: false
is encoded by: hsa:NM 013421
is: SBO:0000252
name: _NM_013421_1_e
initial concentration: NaN
type: Species
initial amount: NaN
boundary condition: true
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110061#_a84a2cfe_0048_496d_91dc_3112f837454b
constant: false
initial amount: NaN
boundary condition: true
initial concentration: NaN
name: _AW277253_1_c
has only substance units: false
type: Species
is encoded by: hsa:AW277253
is: SBO:0000252

metaM arachcoa e
type: Species
constant: false
notes: FORMULA: C41H70N7O17P3S CHARGE: -4 INCHI: InChI=1S/C41H74N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-32(50)69-25-24-43-31(49)22-23-44-39(53)36(52)41(2,3)27-62-68(59,60)65-67(57,58)61-26-30-35(64-66(54,55)56)34(51)40(63-30)48-29-47-33-37(42)45-28-46-38(33)48/h28-30,34-36,40,51-52H,4-27H2,1-3H3,(H,43,49)(H,44,53)(H,57,58)(H,59,60)(H2,42,45,46)(H2,54,55,56)/t30-,34-,35-,36+,40-/m1/s1 EHMN_ABBREVIATION: C02041
name: arachidyl coenzyme A
boundary condition: false
is: CHEBI:15527
initial amount: NaN
is: HMDB04258
has only substance units: false
initial concentration: 1.0
is: SBO:0000247

metaM ha e
initial concentration: 1.0
has only substance units: false
name: hyaluronan
constant: false
boundary condition: false
notes: FORMULA: C28H40N2O22 CHARGE: -2 EHMN_ABBREVIATION: C00518
type: Species
initial amount: NaN
is: CHEBI:16336
is: SBO:0000247

metaM sphmyln hs g
is: SBO:0000247
has only substance units: false
notes: FORMULA: C23H48N2O5PFULLRCO CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC02007
initial amount: NaN
is: CHEBI:58216
type: Species
constant: false
name: sphingomyelin betaine
initial concentration: 1.0
boundary condition: false

metaR INSTt4
name: inositol transport via sodium symport
is described by: ECO:0000269
reactant: MODEL1310110061#
kinetic law: MODEL1310110061#
type: Reaction
fast: false
is: SBO:0000185
product: MODEL1310110061#
notes: GENE_ASSOCIATION: (6526.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12748858,PMID:1372904,PMID:15546855,PMID:7537337,PMID:7789985 NOTES:NCD
reversible: true
modifier: MODEL1310110061#

http://identifiers.org/biomodels.db/MODEL1310110061#_ec06fff3_ebb7_41db_a208_7acc97d0f5a2
is: SBO:0000252
type: Species
boundary condition: true
is encoded by: hsa:38
constant: false
initial concentration: NaN
is: P24752
has only substance units: false
name: ACAT1
initial amount: NaN

metaR r1843
product: MODEL1310110061#
is: SBO:0000185
fast: false
name: Y+LAT2 Utilized transport
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
modifier: MODEL1310110061#
kinetic law: MODEL1310110061#
type: Reaction
reactant: MODEL1310110061#
reversible: false
is described by: ECO:0000000

metaM bilirub c
name: bilirubin(2-)
is: SBO:0000247
initial concentration: 1.0
notes: FORMULA: C33H34N4O6 CHARGE: -2 INCHI: InChI=1S/C33H36N4O6/c1-7-20-19(6)32(42)37-27(20)14-25-18(5)23(10-12-31(40)41)29(35-25)15-28-22(9-11-30(38)39)17(4)24(34-28)13-26-16(3)21(8-2)33(43)36-26/h7-8,13-14,34-35H,1-2,9-12,15H2,3-6H3,(H,36,43)(H,37,42)(H,38,39)(H,40,41)/p-2/b26-13-,27-14- HEPATONET_1.0_ABBREVIATION: HC00385 EHMN_ABBREVIATION: C00486
initial amount: NaN
type: Species
is: HMDB00054
boundary condition: false
constant: false
is: CHEBI:57977
has only substance units: false

metaM dctp n
name: dCTP
boundary condition: false
type: Species
has only substance units: false
is: SBO:0000247
constant: false
initial amount: NaN
initial concentration: 1.0
is: CHEBI:16311
is: C00458
notes: FORMULA: C9H12N3O13P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00367 EHMN_ABBREVIATION: C00458
is: HMDB00998

metaR r0129
is version of: http://identifiers.org/ec-code/2.7.1.40
notes: GENE_ASSOCIATION: (H77542.1) or (5313.1) or (5315.1) SUBSYSTEM: Glutathione metabolism EC Number: 3.4.11.4 Confidence Level: 0 AUTHORS: PMID:1968061,PMID:3511062 NOTES:
is: SBO:0000176
product: MODEL1310110061#
type: Reaction
kinetic law: MODEL1310110061#
reversible: true
name: gamma-glutamyltranspeptidase Glutathione metabolism EC:3.4.11.4
reactant: MODEL1310110061#
fast: false
is described by: ECO:0000000
modifier: MODEL1310110061#

metaR FAOXC164C143m
kinetic law: MODEL1310110061#
product: MODEL1310110061#
reactant: MODEL1310110061#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C16:4-->C14:3)m
type: Reaction

metaR GDPFUCtg
product: MODEL1310110061#
name: GDPFuc Golgi transport via CMP antiport
type: Reaction
modifier: MODEL1310110061#
kinetic law: MODEL1310110061#
fast: false
is described by: ECO:0000269
reversible: true
reactant: MODEL1310110061#
notes: GENE_ASSOCIATION: (55343.1) SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 4 AUTHORS: PMID:11326279,PMID:11326280 NOTES:NCD
is: SBO:0000185

metaM mi1p D c
initial concentration: 1.0
notes: FORMULA: C6H11O9P CHARGE: -2 INCHI: InChI=1S/C6H13O9P/c7-1-2(8)4(10)6(5(11)3(1)9)15-16(12,13)14/h1-11H,(H2,12,13,14)/p-2/t1-,2-,3+,4-,5-,6-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00698
is: CHEBI:58433
is: HMDB02985
initial amount: NaN
constant: false
name: 1D-myo-inositol 1-phosphate(2-)
has only substance units: false
type: Species
is: SBO:0000247
boundary condition: false

metaM 34dhphe c
has only substance units: false
name: L-dopa
boundary condition: false
is: CHEBI:15765
initial concentration: 1.0
is: HMDB00181
is: SBO:0000247
constant: false
initial amount: NaN
notes: FORMULA: C9H11NO4 CHARGE: 0 INCHI: InChI=1S/C9H11NO4/c10-6(9(13)14)3-5-1-2-7(11)8(12)4-5/h1-2,4,6,11-12H,3,10H2,(H,13,14)/t6-/m0/s1
type: Species

http://identifiers.org/biomodels.db/MODEL1310110061#_de3ad265_d275_4e14_80e2_f40c3b1b4338
has part: Q9UHI5
constant: false
has only substance units: false
initial amount: NaN
is encoded by: hsa:23428
name: SLC7A8:SLC3A2
is: SBO:0000297
boundary condition: true
initial concentration: NaN
type: Species

metaM acn13acngalgbside hs e
is: CHEBI:3338
constant: false
initial concentration: 1.0
name: sialyl (1,3) sialyl (2,6) galactosylgloboside
initial amount: NaN
has only substance units: false
is: HMDB00223
notes: FORMULA: C72H121N4O43FULLRCO CHARGE: -2
boundary condition: false
type: Species
is: C00036
is: SBO:0000247

metaM 7dhchsterol r
name: cholesta-5,7-dien-3beta-ol
constant: false
initial amount: NaN
type: Species
initial concentration: 1.0
notes: FORMULA: C27H44O CHARGE: 0 INCHI: InChI=1S/C27H44O/c1-18(2)7-6-8-19(3)23-11-12-24-22-10-9-20-17-21(28)13-15-26(20,4)25(22)14-16-27(23,24)5/h9-10,18-19,21,23-25,28H,6-8,11-17H2,1-5H3/t19-,21+,23-,24+,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00693 EHMN_ABBREVIATION: C01164
is: CHEBI:17759
is: HMDB00032
is: SBO:0000247
has only substance units: false
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110061#_22d5458d_a5ff_48ef_879a_f83f355e89e7
name: CTPS1
is: P17812
type: Species
initial concentration: NaN
is: SBO:0000252
boundary condition: true
has only substance units: false
constant: false
initial amount: NaN
is encoded by: hsa:1503

metaR Coqe
reactant: MODEL1310110061#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
reversible: true
kinetic law: MODEL1310110061#
is described by: ECO:0000134
name: Transport of q10
type: Reaction
product: MODEL1310110061#
fast: false

metaM g3pc c
notes: FORMULA: C8H20NO6P CHARGE: 0 INCHI: InChI=1S/C8H20NO6P/c1-9(2,3)4-5-14-16(12,13)15-7-8(11)6-10/h8,10-11H,4-7H2,1-3H3/p+1/t8-/m1/s1 EHMN_ABBREVIATION: C00670
initial concentration: 1.0
is: HMDB00086
is: SBO:0000247
boundary condition: false
type: Species
initial amount: NaN
constant: false
name: sn-Glycero-3-phosphocholine
has only substance units: false
is: CHEBI:16870

http://identifiers.org/biomodels.db/MODEL1310110061#_4476670f_5a88_40a0_acd9_e73e1faaacf9
name: SYNJ1
has only substance units: false
boundary condition: true
initial concentration: NaN
is: SBO:0000252
initial amount: NaN
is: O43426
type: Species
constant: false
is encoded by: hsa:8867

http://identifiers.org/biomodels.db/MODEL1310110061#_4e34c25f_0df4_40dd_9cb1_de9f5499c6da
constant: false
type: Species
name: FOLR1
initial amount: NaN
is encoded by: hsa:2348
is: SBO:0000252
is: P15328
initial concentration: NaN
has only substance units: false
boundary condition: true

metaR GCC2am
notes: GENE_ASSOCIATION: (275.1) and (1738.1) and (2731.1) and (2653.1) SUBSYSTEM: Glycine, serine, alanine and threonine metabolism EC Number: 2.1.2.10 Confidence Level: 4 AUTHORS: PMID:15355973 NOTES:NCD
product: MODEL1310110061#
is described by: ECO:0000269
type: Reaction
fast: false
reversible: true
name: glycine-cleavage complex (lipoamide), mitochondrial
is version of: http://identifiers.org/ec-code/2.1.2.10
is: SBO:0000176
modifier: MODEL1310110061#
reactant: MODEL1310110061#
is version of: http://identifiers.org/ec-code/1.8.1.4
is version of: http://identifiers.org/ec-code/1.4.4.2
kinetic law: MODEL1310110061#

metaR r1620
kinetic law: MODEL1310110061#
type: Reaction
modifier: MODEL1310110061#
reactant: MODEL1310110061#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (19.1) or (AL038231.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
fast: false
product: MODEL1310110061#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is: SBO:0000185
reversible: true

metaM HC01115 c
has only substance units: false
constant: false
boundary condition: false
name: NeuNGc
is: CHEBI:29025
initial amount: NaN
type: Species
initial concentration: 1.0
notes: FORMULA: C11H18NO10 CHARGE: -1 INCHI: InChI=1S/C11H19NO10/c13-2-5(16)8(18)9-7(12-6(17)3-14)4(15)1-11(21,22-9)10(19)20/h4-5,7-9,13-16,18,21H,1-3H2,(H,12,17)(H,19,20)/p-1/t4-,5+,7+,8+,9+,11?/m0/s1 EHMN_ABBREVIATION: C03410
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110061#_25d550fe_c4cb_4168_8c29_89c95ff8e772
initial amount: NaN
constant: false
boundary condition: true
name: CTPS1
initial concentration: NaN
is: SBO:0000252
type: Species
is: P17812
is encoded by: hsa:1503
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110061#_ec7e5270_4e1c_487a_8d18_e719f6cbe54f
is: SBO:0000252
has only substance units: false
initial amount: NaN
name: CBR1
boundary condition: true
constant: false
is encoded by: hsa:873
type: Species
is: P16152
initial concentration: NaN

metaM docosahexcoa m
initial concentration: 1.0
boundary condition: false
constant: false
has only substance units: false
name: 3,7,10,13,16,19-docosahexenoylcoa
type: Species
notes: FORMULA: C43H62N7O17P3S CHARGE: -4
initial amount: NaN
is: HMDB02288
is: SBO:0000247

metaR RE0569E
type: Reaction
is described by: ECO:0000000
product: MODEL1310110061#
name: RE0569
fast: false
is: SBO:0000176
notes: GENE_ASSOCIATION: (4017.1) SUBSYSTEM: Fatty acid synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:10479480 NOTES:
modifier: MODEL1310110061#
kinetic law: MODEL1310110061#
reactant: MODEL1310110061#
reversible: false

metaR r1384
name: Guanosine aminohydrolase EC:3.5.4.15
reversible: true
kinetic law: MODEL1310110061#
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Nucleotide interconversion EC Number: 3.5.4.15 Confidence Level: 0 AUTHORS: PMID:10348987,PMID:14725335 NOTES:
product: MODEL1310110061#
type: Reaction
is described by: ECO:0000000
fast: false
reactant: MODEL1310110061#

metaR EX dtdp LPAREN e RPAREN
kinetic law: MODEL1310110061#
reactant: MODEL1310110061#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: ({[(2R,3S,5R)-3-hydroxy-5-(5-methyl-2,4-dioxo-1,2,3,4-tetrahydropyrimidin-1-yl)oxolan-2-yl]methyl phosphonato}oxy)phosphonate exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110061#_d9d0c08d_98b9_4e18_8877_ac36e571367e
initial amount: NaN
name: AK2
type: Species
constant: false
is encoded by: hsa:204
initial concentration: NaN
is: SBO:0000252
boundary condition: true
has only substance units: false

metaR THRASNNaEx
reactant: MODEL1310110061#
name: L-threonine/L-asparagine Na-dependent exchange (Thr-L in)
modifier: MODEL1310110061#
kinetic law: MODEL1310110061#
type: Reaction
is: SBO:0000185
fast: false
product: MODEL1310110061#
notes: GENE_ASSOCIATION: (6510.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14530974 NOTES:SAB see Kanai and Hediger 2004 (2003), PMID 14530974
reversible: false
is described by: ECO:0000269

http://identifiers.org/biomodels.db/MODEL1310110061#_77e5ff66_7052_4c8b_8ec8_5e8955f6833d
is: Q9NS18
has only substance units: false
boundary condition: true
name: GLRX2
type: Species
initial amount: NaN
is: SBO:0000252
is encoded by: hsa:51022
initial concentration: NaN
constant: false

metaM dctp m
is: HMDB00998
type: Species
has only substance units: false
initial concentration: 1.0
is: CHEBI:16311
is: SBO:0000247
notes: FORMULA: C9H12N3O13P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00367 EHMN_ABBREVIATION: C00458
constant: false
is: C00458
initial amount: NaN
name: dCTP
boundary condition: false

metaR GLYPHEHYc
kinetic law: MODEL1310110061#
fast: false
is described by: ECO:0000134
name: hydrolysis of glycylphenylalanine
is: SBO:0000176
reversible: true
reactant: MODEL1310110061#
notes: GENE_ASSOCIATION: SUBSYSTEM: Pentose phosphate pathway EC Number: Confidence Level: 1 AUTHORS: most probable reaction. added during gap filling. NOTES:most probable reaction. added during gap filling.
product: MODEL1310110061#
type: Reaction

metaR EX 5dhf LPAREN e RPAREN
kinetic law: MODEL1310110061#
reactant: MODEL1310110061#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: pentaglutamyl folate (DHF) exchange
type: Reaction

metaR RE3568C
reversible: true
is described by: ECO:0000000
is: SBO:0000176
type: Reaction
product: MODEL1310110061#
notes: GENE_ASSOCIATION: SUBSYSTEM: Eicosanoid metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:234423 NOTES:
kinetic law: MODEL1310110061#
fast: false
name: RE3568
reactant: MODEL1310110061#

metaM arachd r
type: Species
boundary condition: false
is: HMDB01043
initial concentration: 1.0
constant: false
is: SBO:0000247
initial amount: NaN
name: arachidonate
is: CHEBI:32395
has only substance units: false
notes: FORMULA: C20H31O2 CHARGE: -1 INCHI: InChI=1S/C20H32O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20(21)22/h6-7,9-10,12-13,15-16H,2-5,8,11,14,17-19H2,1H3,(H,21,22)/p-1/b7-6-,10-9-,13-12-,16-15- HEPATONET_1.0_ABBREVIATION: HC00202 EHMN_ABBREVIATION: C00219

http://identifiers.org/biomodels.db/MODEL1310110061#_9533387b_91f4_48e1_8c77_35bb37adc3e8
is encoded by: hsa:50808
constant: false
has only substance units: false
is: E7ET30
name: AK3
boundary condition: true
initial amount: NaN
is: SBO:0000252
initial concentration: NaN
type: Species

http://identifiers.org/biomodels.db/MODEL1310110061#_c6cab7e0_939d_43a1_97c1_ed732cc94006
has only substance units: false
constant: false
is: Q9NY65
initial concentration: NaN
name: EHHADH
boundary condition: true
initial amount: NaN
type: Species
is encoded by: hsa:1962
is: SBO:0000252

metaR r0990
product: MODEL1310110061#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 0 AUTHORS: PMID:10884298,PMID:6469982 NOTES:
type: Reaction
is: SBO:0000185
fast: false
name: Postulated transport reaction
reversible: true
kinetic law: MODEL1310110061#
reactant: MODEL1310110061#
is described by: ECO:0000000

metaR RBTt
kinetic law: MODEL1310110061#
name: ribitol transport via passive diffusion
reactant: MODEL1310110061#
reversible: false
is: SBO:0000185
is described by: ECO:0000000
fast: false
product: MODEL1310110061#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:15234337 NOTES:NCD

metaM dump c
boundary condition: false
constant: false
is: SBO:0000247
notes: FORMULA: C9H11N2O8P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00309 EHMN_ABBREVIATION: C00365
has only substance units: false
is: C00365
initial amount: NaN
name: dUMP
type: Species
initial concentration: 1.0
is: HMDB01409
is: CHEBI:246422

metaM thbpt4acam c
is: HMDB02281
boundary condition: false
constant: false
type: Species
name: 4a-hydroxytetrahydrobiopterin
is: SBO:0000247
has only substance units: false
initial amount: NaN
initial concentration: 1.0
notes: FORMULA: C9H15N5O4 CHARGE: 0 INCHI: InChI=1S/C9H15N5O4/c1-3(15)5(16)4-2-11-6-9(18,14-4)7(17)13-8(10)12-6/h3-5,14-16,18H,2H2,1H3,(H3,10,11,12,13,17) EHMN_ABBREVIATION: CE1951
is: CHEBI:15374

metaM btn c
type: Species
is: HMDB00030
is: CHEBI:3420
boundary condition: false
name: Biotin
is: C00120
notes: FORMULA: C10H15N2O3S CHARGE: -1
has only substance units: false
initial amount: NaN
constant: false
initial concentration: 1.0
is: SBO:0000247

metaM urea c
is: SBO:0000247
initial concentration: 1.0
initial amount: NaN
notes: FORMULA: CH4N2O CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00089 EHMN_ABBREVIATION: C00086
type: Species
is: CHEBI:16199
is: C00086
is: HMDB00294
constant: false
has only substance units: false
name: Urea
boundary condition: false

metaR AIRCr
modifier: MODEL1310110061#
name: phosphoribosylaminoimidazole carboxylase
reactant: MODEL1310110061#
type: Reaction
kinetic law: MODEL1310110061#
is described by: ECO:0000269
product: MODEL1310110061#
is: SBO:0000176
reversible: true
is version of: http://identifiers.org/ec-code/6.3.2.6
notes: GENE_ASSOCIATION: (10606.1) SUBSYSTEM: Purine synthesis EC Number: Confidence Level: 4 AUTHORS: NOTES:
fast: false

metaR r0236
kinetic law: MODEL1310110061#
name: 5,6-Dihydrouracil:NAD+ oxidoreductase Pyrimidine metabolism EC:1.3.1.1
is described by: ECO:0000000
reactant: MODEL1310110061#
fast: false
is version of: http://identifiers.org/ec-code/3.5.1.6
notes: GENE_ASSOCIATION: (AI640625.1) or (51733.1) SUBSYSTEM: Pyrimidine catabolism EC Number: 1.3.1.1 Confidence Level: 0 AUTHORS: PMID:1260500 NOTES:
product: MODEL1310110061#
reversible: true
is: SBO:0000176
type: Reaction
modifier: MODEL1310110061#

metaM prpp e
initial concentration: 1.0
initial amount: NaN
type: Species
constant: false
is: SBO:0000247
is: CHEBI:58017
is: HMDB00280
name: 5-O-phosphonato-alpha-D-ribofuranosyl diphosphate(5-)
notes: FORMULA: C5H8O14P3 CHARGE: -5 INCHI: InChI=1S/C5H13O14P3/c6-3-2(1-16-20(8,9)10)17-5(4(3)7)18-22(14,15)19-21(11,12)13/h2-7H,1H2,(H,14,15)(H2,8,9,10)(H2,11,12,13)/p-5/t2-,3-,4-,5-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00117 EHMN_ABBREVIATION: C00119
boundary condition: false
has only substance units: false

metaM tettet6coa x
name: tetracosatetraenoyl coenzyme A
initial concentration: 1.0
notes: FORMULA: C45H70N7O17P3S CHARGE: -4 INCHI: InChI=1/C45H74N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-24-25-36(54)73-29-28-47-35(53)26-27-48-43(57)40(56)45(2,3)31-66-72(63,64)69-71(61,62)65-30-34-39(68-70(58,59)60)38(55)44(67-34)52-33-51-37-41(46)49-32-50-42(37)52/h8-9,11-12,14-15,17-18,32-34,38-40,44,55-56H,4-7,10,13,16,19-31H2,1-3H3,(H,47,53)(H,48,57)(H,61,62)(H,63,64)(H2,46,49,50)(H2,58,59,60)/b9-8-,12-11-,15-14-,18-17-/t34-,38-,39?,40+,44-/m1/s1
boundary condition: false
is: HMDB06516
type: Species
is: C16171
constant: false
has only substance units: false
is: SBO:0000247
initial amount: NaN
is: http://identifiers.org/pubchem.compound/47205481

metaR SO4t4 2
product: MODEL1310110061#
name: sulfate transport via sodium symport
is described by: ECO:0000269
kinetic law: MODEL1310110061#
type: Reaction
notes: GENE_ASSOCIATION: (26266.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10535998,PMID:15607730 NOTES:NCD
reversible: true
reactant: MODEL1310110061#
is: SBO:0000185
fast: false
modifier: MODEL1310110061#

metaR FACOAL244 1
kinetic law: MODEL1310110061#
name: fatty-acid--CoA ligase
is version of: http://identifiers.org/ec-code/6.2.1.3
product: MODEL1310110061#
is: SBO:0000176
type: Reaction
reversible: true
reactant: MODEL1310110061#
fast: false
modifier: MODEL1310110061#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (2180.1) SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 4 AUTHORS: PMID:15292367 NOTES:NJ

http://identifiers.org/biomodels.db/MODEL1310110061#_187668c0_e60f_4175_a3fd_477367168903
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:3034
name: HAL
has only substance units: false
is: SBO:0000252
constant: false
is: B4E0V8
boundary condition: true
type: Species

http://identifiers.org/biomodels.db/MODEL1310110061#_d6799ef7_a3ce_4af7_b130_950bcb704dcf
boundary condition: true
is encoded by: hsa:T83654
initial amount: NaN
has only substance units: false
initial concentration: NaN
constant: false
type: Species
name: _T83654_1_e
is: SBO:0000252

metaR LEUt4
notes: GENE_ASSOCIATION: (81539.1) or (84889.1) or (6520.1) or (6542.1) or (6541.1) or (11254.1) or (55089.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10391915,PMID:10891391,PMID:11325958,PMID:11342143,PMID:11414754,PMID:11591158,PMID:11891586,PMID:12049641,PMID:1348489,PMID:1376926,PMID:14770310,PMID:7534987,PMID:8954799 NOTES:SAB
kinetic law: MODEL1310110061#
is: SBO:0000185
reactant: MODEL1310110061#
modifier: MODEL1310110061#
type: Reaction
is described by: ECO:0000269
fast: false
reversible: false
product: MODEL1310110061#
name: L-leucine transport in via sodium symport

http://identifiers.org/biomodels.db/MODEL1310110061#_04430571_2c27_4140_8ce1_05fe97057f8f
is encoded by: hsa:9154
name: SLC28A1
is: Q96PL7
is: SBO:0000252
boundary condition: true
initial concentration: NaN
type: Species
constant: false
initial amount: NaN
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110061#_1fe19416_12d7_44eb_8f08_361d1b80b449
has only substance units: false
is encoded by: hsa:220
initial concentration: NaN
initial amount: NaN
type: Species
constant: false
boundary condition: true
is: P47895
is: SBO:0000252
name: ALDH1A3

metaR PAIL45P HStn
kinetic law: MODEL1310110061#
name: phosphatidylinositol 4,5-bisphosphate nuclear transport (diffusion)
reversible: true
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 1 AUTHORS: NOTES:
product: MODEL1310110061#
reactant: MODEL1310110061#
type: Reaction
is: SBO:0000185
is described by: ECO:0000000

metaR N3Tg
reactant: MODEL1310110061#
product: MODEL1310110061#
is described by: ECO:0000000
modifier: MODEL1310110061#
kinetic law: MODEL1310110061#
is version of: http://identifiers.org/ec-code/2.4.1.122
reversible: false
is: SBO:0000176
name: N-acetylgalactosamine 3-beta-galactosyltransferase, Golgi apparatus
fast: false
type: Reaction
notes: GENE_ASSOCIATION: (56913.1) SUBSYSTEM: O-glycan synthesis EC Number: 2.4.1.122 Confidence Level: 0 AUTHORS: PMID:11677243 NOTES:NCD

metaR FAOXC260240x
name: Beta oxidation of long chain fatty acid
is version of: http://identifiers.org/ec-code/1.3.3.6
is version of: http://identifiers.org/ec-code/1.1.1.35
is version of: http://identifiers.org/ec-code/2.3.1.16
reversible: false
is version of: http://identifiers.org/ec-code/4.2.1.107
kinetic law: MODEL1310110061#
is described by: ECO:0000000
fast: false
product: MODEL1310110061#
type: Reaction
notes: GENE_ASSOCIATION: (3295.1 and 30.1 and 51.2) or (51.1 and 30.1 and 1962.1) or (51.1 and 3295.1 and 30.1) or (30.1 and 51.2 and 1962.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.74 Confidence Level: 4 AUTHORS: NOTES:peroxisomal (very long chain FA) - in peroxisome, no fad, 1ste set of beta-ox is by acyl-coa oxidase (passes electrons directly to o2 -> h2o2) c26:0 -> c24:0 4 step FAO lumped also includes EC 1.1.1.35, 1.1.1.211, 1.3.3.6, 4.2.1.17, 4.2.1.74 -> into pmtcoa NJ
reactant: MODEL1310110061#
is: SBO:0000176
modifier: MODEL1310110061#

metaR CYTK8n
is version of: http://identifiers.org/ec-code/2.7.4.14
product: MODEL1310110061#
modifier: MODEL1310110061#
fast: false
reactant: MODEL1310110061#
name: cytidylate kinase (CMP,dATP),nuclear
is described by: ECO:0000269
type: Reaction
kinetic law: MODEL1310110061#
is: SBO:0000176
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110061#_e37ada0f_2e4a_47db_8e21_58e9cd76be29
initial concentration: NaN
initial amount: NaN
has only substance units: false
constant: false
is: SBO:0000252
type: Species
name: A4GALT
is encoded by: hsa:53947
is: Q9NPC4
boundary condition: true

metaM acn13acngalgbside hs g
constant: false
initial amount: NaN
is: HMDB00223
initial concentration: 1.0
name: sialyl (1,3) sialyl (2,6) galactosylgloboside
has only substance units: false
notes: FORMULA: C72H121N4O43FULLRCO CHARGE: -2
boundary condition: false
is: C00036
is: SBO:0000247
type: Species
is: CHEBI:3338

metaM glc D r
is: HMDB00122
has only substance units: false
is: SBO:0000247
initial concentration: 1.0
type: Species
initial amount: NaN
notes: FORMULA: C6H12O6 CHARGE: 0 INCHI: InChI=1S/C6H12O6/c7-1-2-3(8)4(9)5(10)6(11)12-2/h2-11H,1H2/t2-,3-,4+,5-,6?/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00040
is: CHEBI:4167
boundary condition: false
constant: false
name: D-glucose

metaM 5hoxindact c
initial amount: NaN
is: HMDB04073
constant: false
is: CHEBI:50157
notes: FORMULA: C10H9NO2 CHARGE: 0 INCHI: InChI=1S/C10H9NO2/c12-4-3-7-6-11-10-2-1-8(13)5-9(7)10/h1-2,4-6,11,13H,3H2 HEPATONET_1.0_ABBREVIATION: HC01536 EHMN_ABBREVIATION: C05634
has only substance units: false
name: (5-hydroxyindol-3-yl)acetaldehyde
is: SBO:0000247
boundary condition: false
type: Species
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110061#_2b52be85_6a7d_47a2_bb2a_fdb8792fde4d
initial concentration: NaN
is: SBO:0000252
initial amount: NaN
boundary condition: true
has only substance units: false
name: COQ6
constant: false
is encoded by: hsa:51004
is: Q9Y2Z9
type: Species

metaR DOLGPP Ler
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: N-glycan synthesis EC Number: 3.1.4.48 Confidence Level: 0 AUTHORS: PMID:12137737 NOTES:
reactant: MODEL1310110061#
type: Reaction
is: SBO:0000176
reversible: false
is described by: ECO:0000000
name: Dolichyl-beta-D-glucosyl-phosphate dolichylphosphohydrolase (liver)
product: MODEL1310110061#
kinetic law: MODEL1310110061#

http://identifiers.org/biomodels.db/MODEL1310110061#_413b21fd_bd19_4f48_90bb_59ee59595f5d
boundary condition: true
is encoded by: hsa:2582
initial amount: NaN
type: Species
constant: false
name: GALE
has only substance units: false
is: Q14376
initial concentration: NaN
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110061#_f385f53f_2737_463c_a6f9_8d5a317a1339
is: SBO:0000252
initial concentration: NaN
has only substance units: false
boundary condition: true
type: Species
is: B7Z2M9
initial amount: NaN
constant: false
is encoded by: hsa:8525
name: DGKZ

metaM hexc c
has only substance units: false
initial amount: NaN
name: cerotate
type: Species
boundary condition: false
initial concentration: 1.0
is: CHEBI:31013
is: SBO:0000247
notes: FORMULA: C26H51O2 CHARGE: -1 INCHI: InChI=1S/C26H52O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-24-25-26(27)28/h2-25H2,1H3,(H,27,28)/p-1
is: HMDB02356
constant: false

metaM 10fthf e
constant: false
type: Species
boundary condition: false
has only substance units: false
initial amount: NaN
is: SBO:0000247
initial concentration: 1.0
is: HMDB00972
name: 10-formyltetrahydrofolate(2-)
notes: FORMULA: C20H21N7O7 CHARGE: -2 INCHI: InChI=1S/C20H23N7O7/c21-20-25-16-15(18(32)26-20)23-11(7-22-16)8-27(9-28)12-3-1-10(2-4-12)17(31)24-13(19(33)34)5-6-14(29)30/h1-4,9,11,13,23H,5-8H2,(H,24,31)(H,29,30)(H,33,34)(H4,21,22,25,26,32)/p-2/t11-,13+/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00212 EHMN_ABBREVIATION: C00234
is: CHEBI:57454

http://identifiers.org/biomodels.db/MODEL1310110061#_fcf3fae4_e412_49aa_847e_eba8d231e4c4
is: SBO:0000252
is encoded by: hsa:4023
has only substance units: false
type: Species
boundary condition: true
name: LPL
constant: false
is: P06858
initial concentration: NaN
initial amount: NaN

metaM crn c
notes: FORMULA: C7H15NO3 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00270 EHMN_ABBREVIATION: C00318
is: C00318
is: HMDB00062
is: SBO:0000247
initial concentration: 1.0
is: CHEBI:16347
has only substance units: false
name: L-Carnitine
initial amount: NaN
constant: false
boundary condition: false
type: Species

metaR r1020
type: Reaction
is: SBO:0000185
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:10884298,PMID:6469982 NOTES:
is described by: ECO:0000000
kinetic law: MODEL1310110061#
product: MODEL1310110061#
fast: false
reactant: MODEL1310110061#
name: Postulated transport reaction

metaR TCYNTt
kinetic law: MODEL1310110061#
fast: false
name: Thiocyanate transport via diffusion (cytosol to extracellular)
reversible: false
is described by: ECO:0000000
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:6351723 NOTES:thiocyanate is found excreted in urine (PMID: 6351723) MM
reactant: MODEL1310110061#
is: SBO:0000185
product: MODEL1310110061#

metaM mn l
boundary condition: false
is: SBO:0000247
name: beta-1,4-mannose-N-acetylglucosamine
type: Species
initial amount: NaN
is: HMDB06535
initial concentration: 1.0
has only substance units: false
notes: FORMULA: C14H25NO11 CHARGE: 0 INCHI: InChI=1/C14H25NO11/c1-4(18)15-7-9(20)12(6(3-17)24-13(7)23)26-14-11(22)10(21)8(19)5(2-16)25-14/h5-14,16-17,19-23H,2-3H2,1H3,(H,15,18)/t5-,6-,7-,8-,9-,10+,11+,12-,13-,14-/m1/s1
constant: false

metaR C226CPT2
name: C226 transport into the mitochondria
notes: GENE_ASSOCIATION: (1376.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: PMID:11274214,PMID:1528846,PMID:1988962 NOTES:TDV
fast: false
product: MODEL1310110061#
is: SBO:0000176
reactant: MODEL1310110061#
kinetic law: MODEL1310110061#
type: Reaction
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/2.3.1.21
reversible: false
modifier: MODEL1310110061#

metaR r2534
reversible: true
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:10049700,PMID:10574970,PMID:11389679,PMID:11557028,PMID:11564694,PMID:12824232,PMID:12930836,PMID:14574404,PMID:16288981,PMID:911815 NOTES:
type: Reaction
fast: false
product: MODEL1310110061#
is described by: ECO:0000000
kinetic law: MODEL1310110061#
name: Major Facilitator(MFS) TCDB:2.A.1.44.1
reactant: MODEL1310110061#

metaR RE1807C
reactant: MODEL1310110061#
type: Reaction
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Bile acid synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:9660774 NOTES:
product: MODEL1310110061#
kinetic law: MODEL1310110061#
is described by: ECO:0000000
is: SBO:0000176
name: RE1807
fast: false

metaM CE5854 e
boundary condition: false
notes: FORMULA: C21H27O10 CHARGE: -1 INCHI: InChI=1/C21H28O10/c1-9-10(2)17-11(8-12(9)22)4-6-21(3,31-17)7-5-13(23)29-20-16(26)14(24)15(25)18(30-20)19(27)28/h8,14-16,18,20,22,24-26H,4-7H2,1-3H3,(H,27,28)/p-1/t14-,15+,16-,18-,20+,21?/m1/s1 EHMN_ABBREVIATION: CE5854
is: HMDB02710
is: SBO:0000247
type: Species
initial concentration: 1.0
name: gama-CEHC-glucuronide
has only substance units: false
initial amount: NaN
constant: false
is: CHEBI:27485

metaR r1629
reactant: MODEL1310110061#
is: SBO:0000185
fast: false
product: MODEL1310110061#
is described by: ECO:0000000
kinetic law: MODEL1310110061#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reversible: true
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1

http://identifiers.org/biomodels.db/MODEL1310110061#_eceac9b0_c8df_4198_9527_8c00c0304442
is: GO:0005737
is: SBO:0000290
constant: false
size: 1.0
spatial dimensions: 3.0
name: cytoplasm
type: Compartment

metaM T antigen g
name: T antigen (core 1)
initial amount: NaN
boundary condition: false
is: CHEBI:22783
type: Species
has only substance units: false
is: SBO:0000247
constant: false
initial concentration: 1.0
notes: FORMULA: C14H24NO10X CHARGE: 0

metaM btn e
is: C00120
initial amount: NaN
initial concentration: 1.0
is: CHEBI:3420
has only substance units: false
notes: FORMULA: C10H15N2O3S CHARGE: -1
constant: false
is: HMDB00030
boundary condition: false
name: Biotin
type: Species
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110061#_e323138e_9adf_4571_ba40_7ce583dc4ca4
is: Q16881
boundary condition: true
type: Species
initial amount: NaN
is encoded by: hsa:7296
is: SBO:0000252
initial concentration: NaN
has only substance units: false
constant: false
name: TXNRD1

metaR EX cgly LPAREN e RPAREN
kinetic law: MODEL1310110061#
reactant: MODEL1310110061#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Cys-Gly exchange
type: Reaction

metaR ACN13ACNGALGBSIDEtg
reactant: MODEL1310110061#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 1 AUTHORS: PMID:8206147 NOTES:unknown mechanism for transport - intracellular transport occurs, most details are unknown - see for example Varki glycobiology text or numerous reviews (PMID: 8206147) NJ
type: Reaction
name: acn13acngalgbside hs intracellular transport
reversible: true
fast: false
is: SBO:0000185
product: MODEL1310110061#
kinetic law: MODEL1310110061#
is described by: ECO:0000000

metaM 4aphdob c
type: Species
name: 4-(2-aminophenyl)-2,4-dioxobutanoate
constant: false
is: CHEBI:58147
is: HMDB00978
initial concentration: 1.0
boundary condition: false
is: SBO:0000247
notes: FORMULA: C10H8NO4 CHARGE: -1 INCHI: InChI=1S/C10H9NO4/c11-7-4-2-1-3-6(7)8(12)5-9(13)10(14)15/h1-4H,5,11H2,(H,14,15)/p-1 EHMN_ABBREVIATION: C01252
initial amount: NaN
has only substance units: false

metaM prostgi2 e
initial amount: NaN
notes: FORMULA: C20H31O5 CHARGE: -1 INCHI: InChI=1S/C20H32O5/c1-2-3-4-7-14(21)10-11-16-17-12-15(8-5-6-9-20(23)24)25-19(17)13-18(16)22/h8,10-11,14,16-19,21-22H,2-7,9,12-13H2,1H3,(H,23,24)/p-1/b11-10+,15-8-/t14-,16+,17+,18+,19-/m0/s1 EHMN_ABBREVIATION: C01312
type: Species
boundary condition: false
name: prostaglandin I2(1-)
is: HMDB01335
is: CHEBI:57403
constant: false
initial concentration: 1.0
is: SBO:0000247
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110061#_02aa542d_4fd9_4b83_9c22_d340e8dc0a82
name: PYCRL
has only substance units: false
constant: false
is: SBO:0000252
initial amount: NaN
boundary condition: true
is: Q53H96
type: Species
is encoded by: hsa:65263
initial concentration: NaN

metaM eicostet e
type: Species
initial concentration: 1.0
constant: false
notes: FORMULA: C20H31O2 CHARGE: -1
is: HMDB02177
is: SBO:0000247
boundary condition: false
name: eicosatetranoic acid
has only substance units: false
is: CHEBI:36033
initial amount: NaN

metaM citr L c
notes: FORMULA: C6H13N3O3 CHARGE: 0 INCHI: InChI=1S/C6H13N3O3/c7-4(5(10)11)2-1-3-9-6(8)12/h4H,1-3,7H2,(H,10,11)(H3,8,9,12)/t4-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00277
type: Species
initial concentration: 1.0
constant: false
is: SBO:0000247
is: CHEBI:16349
name: L-citrulline
initial amount: NaN
has only substance units: false
is: HMDB00904
boundary condition: false

metaM HC00250 c
boundary condition: false
initial concentration: 1.0
initial amount: NaN
is: SBO:0000247
constant: false
has only substance units: false
name: hydrosulfide
type: Species
notes: FORMULA: HS CHARGE: -1 INCHI: InChI=1S/H2S/h1H2/p-1 EHMN_ABBREVIATION: C00283
is: CHEBI:29919

metaM fum m
initial amount: NaN
is: C00122
notes: FORMULA: C4H2O4 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00120 EHMN_ABBREVIATION: C00122
name: Fumarate
is: SBO:0000247
is: HMDB00134
constant: false
type: Species
has only substance units: false
initial concentration: 1.0
is: CHEBI:29806
boundary condition: false

metaR r2535
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:10049700,PMID:10574970,PMID:11389679,PMID:11557028,PMID:11564694,PMID:12824232,PMID:12930836,PMID:14574404,PMID:16288981,PMID:911815 NOTES:
type: Reaction
product: MODEL1310110061#
is described by: ECO:0000000
kinetic law: MODEL1310110061#
name: Major Facilitator(MFS) TCDB:2.A.1.44.1
reactant: MODEL1310110061#
is: SBO:0000185
fast: false
reversible: true

metaR O2Stm
is described by: ECO:0000000
kinetic law: MODEL1310110061#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: PMID:12939409 NOTES:
reactant: MODEL1310110061#
is: SBO:0000185
type: Reaction
reversible: true
fast: false
name: superoxide anion transport via diffusion (mitochondria)
product: MODEL1310110061#

metaR C226CPT1
is version of: http://identifiers.org/ec-code/2.3.1.21
fast: false
reversible: false
modifier: MODEL1310110061#
kinetic law: MODEL1310110061#
name: carnitine C22:6 transferase
is: SBO:0000176
product: MODEL1310110061#
reactant: MODEL1310110061#
type: Reaction
notes: GENE_ASSOCIATION: (126129.1) or (1375.3) or (1374.1) or (1375.2) or (1375.1) or (1375.4) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.21 Confidence Level: 4 AUTHORS: PMID:1988962 NOTES:TDV
is described by: ECO:0000000

metaR EX trp L LPAREN e RPAREN
kinetic law: MODEL1310110061#
reactant: MODEL1310110061#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: L-Tryptophan exchange
type: Reaction

metaR C3STDH1Pr
reactant: MODEL1310110061#
is described by: ECO:0000134
notes: GENE_ASSOCIATION: (50814.1) SUBSYSTEM: Cholesterol metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:10710235,PMID:14506130 NOTES:NCD ER version NJ
is version of: http://identifiers.org/ec-code/1.1.1.170
name: C-3 sterol dehydrogenase (4-methylzymosterol)
reversible: false
fast: false
modifier: MODEL1310110061#
kinetic law: MODEL1310110061#
is: SBO:0000176
product: MODEL1310110061#
type: Reaction

metaM 34dhphe e
name: L-dopa
is: SBO:0000247
boundary condition: false
type: Species
initial concentration: 1.0
constant: false
is: CHEBI:15765
notes: FORMULA: C9H11NO4 CHARGE: 0 INCHI: InChI=1S/C9H11NO4/c10-6(9(13)14)3-5-1-2-7(11)8(12)4-5/h1-2,4,6,11-12H,3,10H2,(H,13,14)/t6-/m0/s1
has only substance units: false
initial amount: NaN
is: HMDB00181

metaR EX n2m2nmasn LPAREN e RPAREN
kinetic law: MODEL1310110061#
reactant: MODEL1310110061#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: N-Acetyl-beta-D-glucosaminyl-1,2-alpha-D-mannosyl-1,3-(N-acetyl-beta-D-glucosaminyl-1,2-alpha-D-mannosyl-1,6)-(N-acetyl-beta-D-glucosaminyl-1,4)-beta-D-mannosyl-1,4-N-acetyl-beta-D-glucosaminyl-R exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110061#_e7746ced_87f4_44c3_9616_366d6ba9fa0e
initial concentration: NaN
is: P11310
is: SBO:0000252
boundary condition: true
initial amount: NaN
is encoded by: hsa:34
name: ACADM
has only substance units: false
constant: false
type: Species

metaM pe hs m
name: phosphatidylethanolamine
notes: FORMULA: C5H12NO4PFULLRCO2FULLR2CO2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC02002 EHMN_ABBREVIATION: C00350
constant: false
type: Species
is: CHEBI:16038
boundary condition: false
has only substance units: false
initial concentration: 1.0
is: SBO:0000247
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110061#_8b7546b7_9e52_46d6_9582_c32d5fb1eeb3
is: O00154
type: Species
constant: false
name: ACOT7
is: SBO:0000252
boundary condition: true
initial concentration: NaN
has only substance units: false
initial amount: NaN
is encoded by: hsa:11332

metaR ESTRADIOLt
name: estradiol transport
kinetic law: MODEL1310110061#
type: Reaction
reversible: true
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:
reactant: MODEL1310110061#
fast: false
is described by: ECO:0000000
product: MODEL1310110061#

metaR RE0583C
name: RE0583
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:10479480 NOTES:
fast: false
is described by: ECO:0000000
kinetic law: MODEL1310110061#
is: SBO:0000176
product: MODEL1310110061#
reversible: true
type: Reaction
reactant: MODEL1310110061#

metaR BHBtm
reversible: true
kinetic law: MODEL1310110061#
is described by: ECO:0000000
reactant: MODEL1310110061#
type: Reaction
name: (R)-3-Hydroxybutanoate mitochondrial transport via H+ symport
product: MODEL1310110061#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:3427918 NOTES:IT, TDV
fast: false

http://identifiers.org/biomodels.db/MODEL1310110061#_d36e5c05_3779_47ae_b72f_3d57d3aded35
is: SBO:0000252
type: Species
initial concentration: NaN
constant: false
is encoded by: hsa:113026
boundary condition: true
initial amount: NaN
is: Q8N3E9
has only substance units: false
name: PLCD3

http://identifiers.org/biomodels.db/MODEL1310110061#_c7fe651b_ae62_43cb_bc23_f7f307ac478e
initial amount: NaN
has only substance units: false
is: SBO:0000252
name: DTYMK
boundary condition: true
is: P23919
constant: false
initial concentration: NaN
is encoded by: hsa:1841
type: Species

metaR ACACT1rm
type: Reaction
modifier: MODEL1310110061#
kinetic law: MODEL1310110061#
is version of: http://identifiers.org/ec-code/2.3.1.9
reversible: true
notes: GENE_ASSOCIATION: (3030.1) and (3032.1) or (38.1) SUBSYSTEM: Tryptophan metabolism EC Number: 2.3.1.9 Confidence Level: 0 AUTHORS: NOTES:TDV
name: acetyl-CoA C-acetyltransferase, mitochondrial
fast: false
is version of: http://identifiers.org/ec-code/4.2.1.17
is version of: http://identifiers.org/ec-code/2.3.1.16
is described by: ECO:0000000
reactant: MODEL1310110061#
is: SBO:0000176
product: MODEL1310110061#

metaM urcan c
is: HMDB00301
boundary condition: false
constant: false
name: Urocanate
initial amount: NaN
notes: FORMULA: C6H5N2O2 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00534 EHMN_ABBREVIATION: C00785
is: SBO:0000247
is: CHEBI:17771
type: Species
initial concentration: 1.0
is: C00785
has only substance units: false

metaM bilirub e
notes: FORMULA: C33H34N4O6 CHARGE: -2 INCHI: InChI=1S/C33H36N4O6/c1-7-20-19(6)32(42)37-27(20)14-25-18(5)23(10-12-31(40)41)29(35-25)15-28-22(9-11-30(38)39)17(4)24(34-28)13-26-16(3)21(8-2)33(43)36-26/h7-8,13-14,34-35H,1-2,9-12,15H2,3-6H3,(H,36,43)(H,37,42)(H,38,39)(H,40,41)/p-2/b26-13-,27-14- HEPATONET_1.0_ABBREVIATION: HC00385 EHMN_ABBREVIATION: C00486
boundary condition: false
is: HMDB00054
is: CHEBI:57977
type: Species
is: SBO:0000247
name: bilirubin(2-)
constant: false
has only substance units: false
initial concentration: 1.0
initial amount: NaN

metaM pep c
is: SBO:0000247
initial amount: NaN
initial concentration: 1.0
is: C00074
notes: FORMULA: C3H2O6P CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00076 EHMN_ABBREVIATION: C00074
name: Phosphoenolpyruvate
is: HMDB00263
type: Species
has only substance units: false
is: CHEBI:18021
boundary condition: false
constant: false

http://identifiers.org/biomodels.db/MODEL1310110061#_3d9ebf43_9a8e_4a23_ba6a_266d95e12517
type: Species
constant: false
name: B4GALT2
initial concentration: NaN
has only substance units: false
is: SBO:0000252
is encoded by: hsa:8704
is: O60909
initial amount: NaN
boundary condition: true

metaR r2532
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:10049700,PMID:10574970,PMID:11389679,PMID:11557028,PMID:11564694,PMID:12824232,PMID:12930836,PMID:14574404,PMID:16288981,PMID:911815 NOTES:
reversible: true
product: MODEL1310110061#
is: SBO:0000185
name: Major Facilitator(MFS) TCDB:2.A.1.44.1
fast: false
type: Reaction
kinetic law: MODEL1310110061#
reactant: MODEL1310110061#
is described by: ECO:0000000

metaR r0450
kinetic law: MODEL1310110061#
is version of: http://identifiers.org/ec-code/4.2.1.3
name: L-2-Aminoadipate:2-oxoglutarate aminotransferase Lysine biosynthesis / Lysine degradation EC:2.6.1.39
fast: false
product: MODEL1310110061#
notes: GENE_ASSOCIATION: (AA278423.1) or (48.1) or (50.1) SUBSYSTEM: Lysine metabolism EC Number: 2.6.1.39 Confidence Level: 0 AUTHORS: PMID:8087205 NOTES:
modifier: MODEL1310110061#
reversible: true
is described by: ECO:0000000
reactant: MODEL1310110061#
is: SBO:0000176
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110061#_cb711549_c531_4148_b66b_728e9b94b399
is: SBO:0000252
has only substance units: false
boundary condition: true
constant: false
name: AHCYL1
type: Species
initial amount: NaN
is encoded by: hsa:10768
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110061#_83c905aa_85cb_4b3f_8238_45b2a7cd7607
has only substance units: false
constant: false
name: DPYD
initial amount: NaN
is: SBO:0000252
boundary condition: true
is: Q12882
initial concentration: NaN
type: Species
is encoded by: hsa:1806

metaM eicostet c
initial concentration: 1.0
is: SBO:0000247
has only substance units: false
initial amount: NaN
is: CHEBI:36033
type: Species
boundary condition: false
constant: false
name: eicosatetranoic acid
is: HMDB02177
notes: FORMULA: C20H31O2 CHARGE: -1

metaM methf c
notes: FORMULA: C20H20N7O6 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00360 EHMN_ABBREVIATION: C00445
has only substance units: false
is: HMDB01354
name: 5,10-Methenyltetrahydrofolate
is: C00445
boundary condition: false
initial amount: NaN
constant: false
initial concentration: 1.0
is: CHEBI:57455
type: Species
is: SBO:0000247

metaM HC00250 e
initial amount: NaN
is: SBO:0000247
constant: false
boundary condition: false
initial concentration: 1.0
type: Species
name: hydrosulfide
has only substance units: false
notes: FORMULA: HS CHARGE: -1 INCHI: InChI=1S/H2S/h1H2/p-1 EHMN_ABBREVIATION: C00283
is: CHEBI:29919

metaR ACN13ACNGALGBSIDEte
fast: false
is described by: ECO:0000000
product: MODEL1310110061#
reactant: MODEL1310110061#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 1 AUTHORS: PMID:8206147 NOTES:unknown mechanism for transport - intracellular transport occurs, most details are unknown - see for example Varki glycobiology text or numerous reviews (PMID: 8206147) - extracellular transport is also made available since metabolites can get to outer plasma membrane NJ
kinetic law: MODEL1310110061#
name: acn13acngalgbside hs transport
reversible: true
is: SBO:0000185

metaR RE2799C
is: SBO:0000176
fast: false
product: MODEL1310110061#
reactant: MODEL1310110061#
reversible: true
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Eicosanoid metabolism EC Number: 1.1.1.188 Confidence Level: 0 AUTHORS: PMID:12543809,PMID:7948008 NOTES:
kinetic law: MODEL1310110061#
name: RE2799
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110061#_d1824d1d_bb63_413b_a9f8_75e7391c84c5
name: HLCS
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:3141
is: P50747
constant: false
type: Species
boundary condition: true
is: SBO:0000252
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110061#_e3e83bd6_15ad_4d8b_8356_1b92fa8ae136
name: PANK2
type: Species
is: SBO:0000252
boundary condition: true
initial concentration: NaN
is: Q6P1K9
initial amount: NaN
has only substance units: false
constant: false
is encoded by: hsa:80025

metaR RE3014R
type: Reaction
notes: GENE_ASSOCIATION: (8529.1) or (4051.1) or (126410.1) SUBSYSTEM: Eicosanoid metabolism EC Number: 1.14.13.30 Confidence Level: 0 AUTHORS: PMID:11368003,PMID:9799565,PMID:9862787 NOTES:
kinetic law: MODEL1310110061#
is described by: ECO:0000000
product: MODEL1310110061#
is version of: http://identifiers.org/ec-code/1.14.13.30
is: SBO:0000176
fast: false
reactant: MODEL1310110061#
name: RE3014
reversible: false
modifier: MODEL1310110061#

http://identifiers.org/biomodels.db/MODEL1310110061#_97249dd5_be52_4c81_9a6b_cdcd6c5040ff
constant: false
name: GCAT
is: SBO:0000252
type: Species
has only substance units: false
boundary condition: true
is encoded by: hsa:23464
initial amount: NaN
is: E2QC23
initial concentration: NaN

metaM idp e
constant: false
name: IDP(3-)
is: HMDB03335
type: Species
is: SBO:0000247
initial concentration: 1.0
has only substance units: false
is: CHEBI:58280
initial amount: NaN
notes: FORMULA: C10H11N4O11P2 CHARGE: -3 INCHI: InChI=1S/C10H14N4O11P2/c15-6-4(1-23-27(21,22)25-26(18,19)20)24-10(7(6)16)14-3-13-5-8(14)11-2-12-9(5)17/h2-4,6-7,10,15-16H,1H2,(H,21,22)(H,11,12,17)(H2,18,19,20)/p-3/t4-,6-,7-,10-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00104 EHMN_ABBREVIATION: C00104
boundary condition: false

metaM frdp x
notes: FORMULA: C15H25O7P2 CHARGE: -3 INCHI: InChI=1S/C15H28O7P2/c1-13(2)7-5-8-14(3)9-6-10-15(4)11-12-21-24(19,20)22-23(16,17)18/h7,9,11H,5-6,8,10,12H2,1-4H3,(H,19,20)(H2,16,17,18)/p-3/b14-9+,15-11+ HEPATONET_1.0_ABBREVIATION: HC00362 EHMN_ABBREVIATION: C00448
has only substance units: false
is: CHEBI:175763
name: farnesyl pyrophosphate(3-)
is: SBO:0000247
is: HMDB00961
boundary condition: false
initial amount: NaN
type: Species
constant: false
initial concentration: 1.0

metaM dhbpt c
notes: FORMULA: C9H13N5O3 CHARGE: 0 INCHI: InChI=1S/C9H13N5O3/c1-3(15)6(16)4-2-11-7-5(12-4)8(17)14-9(10)13-7/h3-4,6,15-16H,2H2,1H3,(H3,10,11,13,14,17) HEPATONET_1.0_ABBREVIATION: HC00242 EHMN_ABBREVIATION: C00268
name: 6,7-dihydrobiopterin
is: SBO:0000247
initial amount: NaN
initial concentration: 1.0
has only substance units: false
type: Species
boundary condition: false
is: HMDB00038
constant: false
is: CHEBI:20680

metaR EX dheas LPAREN e RPAREN
kinetic law: MODEL1310110061#
reactant: MODEL1310110061#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Dehydroepiandrosterone sulfate exchange
type: Reaction

metaR FAOXC226C205m
kinetic law: MODEL1310110061#
product: MODEL1310110061#
reactant: MODEL1310110061#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C22:6-->C20:5)m
type: Reaction

metaR EX o2 LPAREN e RPAREN
kinetic law: MODEL1310110061#
reactant: MODEL1310110061#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for oxugen
type: Reaction

metaM pydx c
boundary condition: false
is: C00250
is: SBO:0000247
initial concentration: 1.0
name: Pyridoxal
is: CHEBI:17310
notes: FORMULA: C8H9NO3 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00227 EHMN_ABBREVIATION: C00250
is: HMDB01545
constant: false
type: Species
initial amount: NaN
has only substance units: false

metaM clpndcoa c
is: http://identifiers.org/pubchem.compound/47205476
boundary condition: false
type: Species
is: HMDB06267
is: C16166
is: SBO:0000247
constant: false
notes: FORMULA: C43H64N7O17P3S CHARGE: -4 INCHI: InChI=1/C43H68N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-34(52)71-27-26-45-33(51)24-25-46-41(55)38(54)43(2,3)29-64-70(61,62)67-69(59,60)63-28-32-37(66-68(56,57)58)36(53)42(65-32)50-31-49-35-39(44)47-30-48-40(35)50/h5-6,8-9,11-12,14-15,17-18,30-32,36-38,42,53-54H,4,7,10,13,16,19-29H2,1-3H3,(H,45,51)(H,46,55)(H,59,60)(H,61,62)(H2,44,47,48)(H2,56,57,58)/p-4/b6-5-,9-8-,12-11-,15-14-,18-17-/t32-,36+,37+,38?,42-/m0/s1
initial amount: NaN
name: clupanodonyl CoA
initial concentration: 1.0
has only substance units: false

metaR GLUPRT
reversible: false
name: glutamine phosphoribosyldiphosphate amidotransferase
type: Reaction
notes: GENE_ASSOCIATION: (5471.1) SUBSYSTEM: Purine synthesis EC Number: 2.4.2.14 Confidence Level: 4 AUTHORS: PMID:8106516,PMID:8380692,PMID:9108165 NOTES:
reactant: MODEL1310110061#
fast: false
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/2.4.2.14
is: SBO:0000176
product: MODEL1310110061#
kinetic law: MODEL1310110061#
modifier: MODEL1310110061#

metaR r1625
reactant: MODEL1310110061#
kinetic law: MODEL1310110061#
product: MODEL1310110061#
is described by: ECO:0000000
type: Reaction
is: SBO:0000185
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
modifier: MODEL1310110061#
fast: false
notes: GENE_ASSOCIATION: (19.1) or (AL038231.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110061#_efe0652c_927c_47d3_b693_2e637d4f3c7d
is: SBO:0000252
initial amount: NaN
initial concentration: NaN
is: O00330
name: PDHX
has only substance units: false
constant: false
is encoded by: hsa:8050
type: Species
boundary condition: true

metaM tmndnc e
is: http://identifiers.org/pubchem.compound/446284
notes: FORMULA: C20H29O2 CHARGE: -1 INCHI: InChI=1/C20H30O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20(21)22/h3-4,6-7,9-10,12-13,15-16H,2,5,8,11,14,17-19H2,1H3,(H,21,22)/b4-3-,7-6-,10-9-,13-12-,16-15-
boundary condition: false
has only substance units: false
initial concentration: 1.0
name: timnodonic acid C20:5, n-3
type: Species
is: HMDB01999
initial amount: NaN
is: SBO:0000247
constant: false

metaR MEOHt2
fast: false
reactant: MODEL1310110061#
product: MODEL1310110061#
is described by: ECO:0000000
name: Methanol diffusion
is: SBO:0000185
reversible: true
kinetic law: MODEL1310110061#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:
type: Reaction

metaR BILDGLCURtr
type: Reaction
is described by: ECO:0000000
reversible: true
reactant: MODEL1310110061#
product: MODEL1310110061#
name: glucuronidated compound transport
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: NOTES:unknown mechanism, however glucuronidated metabolites need to get out of the cell NJ
kinetic law: MODEL1310110061#
fast: false
is: SBO:0000185

metaM dutp m
is: SBO:0000247
notes: FORMULA: C9H11N2O14P3 CHARGE: -4 INCHI: InChI=1S/C9H15N2O14P3/c12-5-3-8(11-2-1-7(13)10-9(11)14)23-6(5)4-22-27(18,19)25-28(20,21)24-26(15,16)17/h1-2,5-6,8,12H,3-4H2,(H,18,19)(H,20,21)(H,10,13,14)(H2,15,16,17)/t5-,6+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00369 EHMN_ABBREVIATION: C00460
initial amount: NaN
is: CHEBI:17625
boundary condition: false
has only substance units: false
name: dUTP
type: Species
initial concentration: 1.0
constant: false
is: HMDB01191

http://identifiers.org/biomodels.db/MODEL1310110061#_5ea00f14_8815_49ac_9299_27e295188864
is encoded by: hsa:341947
is encoded by: hsa:9167
has part: Q7Z4L0
is encoded by: hsa:1327
has only substance units: false
initial amount: NaN
has part: Q6YFQ2
has part: Q7GXZ8
has part: Q96KJ9
is encoded by: hsa:1349
is encoded by: hsa:9377
has part: Q02221
is encoded by: hsa:1346
is encoded by: hsa:125965
has part: P12074
has part: Q7GXY8
constant: false
name: COX6B2:COX4I1:COX5B:COX6A1:COX6A2:COX6B1:COX6C:COX7A1:COX7A2:COX7B:COX7C:COX8A:COX7B2:COX8C:COX1:COX2:COX3:COX4I2:COX7A2L:COX5A
has part: P13073
has part: P24310
has part: Q53XN1
is encoded by: hsa:1351
has part: P00414
is encoded by: hsa:1339
type: Species
is encoded by: hsa:84701
is: SBO:0000297
has part: Q8TF08
has part: P24311
has part: P20674
is encoded by: hsa:1345
has part: P15954
has part: P09669
is encoded by: hsa:4514
has part: Q6FGA0
is encoded by: hsa:1329
boundary condition: true
has part: Q53YB7
is encoded by: hsa:1340
has part: H0UI06
is encoded by: hsa:1337
initial concentration: NaN
is encoded by: hsa:1350
has part: P14854
is encoded by: hsa:1347
is encoded by: hsa:4512
is encoded by: hsa:170712
is encoded by: hsa:4513

http://identifiers.org/biomodels.db/MODEL1310110061#_e6690264_0939_4d7d_bc98_044abc0b99e2
is encoded by: hsa:5295
boundary condition: true
is: P27986
constant: false
is: SBO:0000252
initial amount: NaN
type: Species
name: PIK3R1
initial concentration: NaN
has only substance units: false

metaM gly m
has only substance units: false
is: CHEBI:15428
is: SBO:0000247
initial concentration: 1.0
name: Glycine
boundary condition: false
constant: false
notes: FORMULA: C2H5NO2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00045 EHMN_ABBREVIATION: C00037
is: C00037
is: HMDB00123
initial amount: NaN
type: Species

metaM dcholcoa r
name: chenodeoxycholoyl coenzyme a
is: CHEBI:28701
notes: FORMULA: C45H70N7O19P3S CHARGE: -4 INCHI: InChI=1S/C45H74N7O19P3S/c1-24(27-7-8-28-34-29(11-14-45(27,28)5)44(4)13-10-26(53)18-25(44)19-30(34)54)6-9-33(56)75-17-16-47-32(55)12-15-48-41(59)38(58)43(2,3)21-68-74(65,66)71-73(63,64)67-20-31-37(70-72(60,61)62)36(57)42(69-31)52-23-51-35-39(46)49-22-50-40(35)52/h22-31,34,36-38,42,53-54,57-58H,6-21H2,1-5H3,(H,47,55)(H,48,59)(H,63,64)(H,65,66)(H2,46,49,50)(H2,60,61,62)/t24-,25+,26-,27-,28+,29+,30-,31-,34+,36-,37-,38+,42-,44+,45-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01426 EHMN_ABBREVIATION: C05337
boundary condition: false
constant: false
has only substance units: false
initial concentration: 1.0
is: HMDB06292
type: Species
initial amount: NaN
is: SBO:0000247

metaR GASNASE2ly
is: SBO:0000176
name: glycosylasparaginase, lysosomal
product: MODEL1310110061#
reversible: false
fast: false
is version of: http://identifiers.org/ec-code/3.5.1.26
reactant: MODEL1310110061#
is described by: ECO:0000000
type: Reaction
modifier: MODEL1310110061#
kinetic law: MODEL1310110061#
notes: GENE_ASSOCIATION: (175.1) SUBSYSTEM: N-glycan degradation EC Number: 3.5.1.26 Confidence Level: 0 AUTHORS: NOTES:NCD

metaR EX C05965 LPAREN e RPAREN
kinetic law: MODEL1310110061#
reactant: MODEL1310110061#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 12(S)-HPETE(1-) exchange
type: Reaction

metaM hdcea r
is: CHEBI:32372
is: SBO:0000247
initial amount: NaN
name: palmitoleate
constant: false
initial concentration: 1.0
has only substance units: false
type: Species
notes: FORMULA: C16H29O2 CHARGE: -1 INCHI: InChI=1S/C16H30O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16(17)18/h7-8H,2-6,9-15H2,1H3,(H,17,18)/p-1/b8-7- HEPATONET_1.0_ABBREVIATION: HC01981 EHMN_ABBREVIATION: CE0850
boundary condition: false
is: HMDB03229

metaR r1626
product: MODEL1310110061#
is described by: ECO:0000000
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
type: Reaction
modifier: MODEL1310110061#
fast: false
notes: GENE_ASSOCIATION: (19.1) or (AL038231.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reversible: true
is: SBO:0000185
reactant: MODEL1310110061#
kinetic law: MODEL1310110061#

metaM HC02187 e
notes: FORMULA: C15H12I3NO4 CHARGE: 0 INCHI: InChI=1S/C15H12I3NO4/c16-9-3-7(4-12(19)15(21)22)1-2-13(9)23-8-5-10(17)14(20)11(18)6-8/h1-3,5-6,12,20H,4,19H2,(H,21,22)
initial amount: NaN
type: Species
is: CHEBI:28774
initial concentration: 1.0
constant: false
boundary condition: false
has only substance units: false
is: SBO:0000247
name: reverse-triiodthyronine

metaR r1378
is: SBO:0000176
reversible: true
type: Reaction
is described by: ECO:0000000
reactant: MODEL1310110061#
kinetic law: MODEL1310110061#
name: S-(hydroxymethyl)glutathione dehydrogenase Methane metabolism EC:1.1.1.284
fast: false
product: MODEL1310110061#
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 1.1.1.284 Confidence Level: 0 AUTHORS: PMID:18288723 NOTES:

metaR CRMPte
kinetic law: MODEL1310110061#
is described by: ECO:0000000
reactant: MODEL1310110061#
fast: false
product: MODEL1310110061#
reversible: true
type: Reaction
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:15585321 NOTES:unknown mechanism for transport, may be vesicular/caveolar/other ... intracellular transport and extracellular export mechanisms must exist - see for example: PMID: 15585321 NJ
name: crmp hs transport

metaM xu5p D c
is: SBO:0000247
boundary condition: false
constant: false
initial amount: NaN
type: Species
is: CHEBI:57737
initial concentration: 1.0
is: HMDB00868
name: D-xylulose 5-phosphate(2-)
notes: FORMULA: C5H9O8P CHARGE: -2 INCHI: InChI=1S/C5H11O8P/c6-1-3(7)5(9)4(8)2-13-14(10,11)12/h4-6,8-9H,1-2H2,(H2,10,11,12)/p-2/t4-,5-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00209
has only substance units: false

metaR DHCHOLESTANATEtm
fast: false
product: MODEL1310110061#
is described by: ECO:0000000
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: PMID:12840657 NOTES:cholesterol precursor, transport by "diffusion" -> actually beleived to be flip-flop mechanism (PMID: 12840657). NJ
reversible: true
reactant: MODEL1310110061#
kinetic law: MODEL1310110061#
name: lipid, flip-flop intracellular transport
type: Reaction

metaR r0999
is: SBO:0000185
name: Facilitated diffusion
kinetic law: MODEL1310110061#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:1735445,PMID:18406340,PMID:1988962,PMID:2351134,PMID:2355017,PMID:6361812,PMID:7892212,PMID:8132483 NOTES:
reactant: MODEL1310110061#
fast: false
is described by: ECO:0000000
reversible: true
type: Reaction
product: MODEL1310110061#

http://identifiers.org/biomodels.db/MODEL1310110061#_7697a14a_fd74_482f_9413_a8bc05d59992
boundary condition: true
has only substance units: false
is encoded by: hsa:27235
constant: false
is: SBO:0000252
initial amount: NaN
initial concentration: NaN
is: Q96H96
name: COQ2
type: Species

metaR CYTK13
product: MODEL1310110061#
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
name: cytidylate kinase (dCMP,dATP)
kinetic law: MODEL1310110061#
reversible: true
is version of: http://identifiers.org/ec-code/2.7.4.14
type: Reaction
reactant: MODEL1310110061#
is described by: ECO:0000269
fast: false
is: SBO:0000176
modifier: MODEL1310110061#

metaM dsmsterol r
initial concentration: 1.0
boundary condition: false
has only substance units: false
type: Species
is: HMDB02719
name: desmosterol
notes: FORMULA: C27H44O CHARGE: 0 INCHI: InChI=1S/C27H44O/c1-18(2)7-6-8-19(3)23-11-12-24-22-10-9-20-17-21(28)13-15-26(20,4)25(22)14-16-27(23,24)5/h7,9,19,21-25,28H,6,8,10-17H2,1-5H3/t19-,21+,22+,23-,24+,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00847 EHMN_ABBREVIATION: C01802
constant: false
is: SBO:0000247
initial amount: NaN
is: CHEBI:17737

metaM 10fthf c
initial concentration: 1.0
is: C00234
notes: FORMULA: C20H21N7O7 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00212 EHMN_ABBREVIATION: C00234
boundary condition: false
initial amount: NaN
has only substance units: false
is: HMDB00972
is: CHEBI:57454
name: 10-Formyltetrahydrofolate
constant: false
is: SBO:0000247
type: Species

http://identifiers.org/biomodels.db/MODEL1310110061#_b483a5c8_02e6_4d58_b371_82b0a3be30d7
has only substance units: false
boundary condition: true
initial concentration: NaN
type: Species
initial amount: NaN
is encoded by: hsa:221823
is: P21108
is: SBO:0000252
constant: false
name: PRPS1L1

http://identifiers.org/biomodels.db/MODEL1310110061#_cc951a7d_fee1_403b_9b5c_dc07556e996b
boundary condition: true
constant: false
is encoded by: hsa:H17063
initial concentration: NaN
type: Species
name: _H17063_1_m
initial amount: NaN
has only substance units: false
is: SBO:0000252

metaM gthox m
is: SBO:0000247
initial amount: NaN
constant: false
is: HMDB03337
type: Species
notes: FORMULA: C20H30N6O12S2 CHARGE: -2 INCHI: InChI=1S/C20H32N6O12S2/c21-9(19(35)36)1-3-13(27)25-11(17(33)23-5-15(29)30)7-39-40-8-12(18(34)24-6-16(31)32)26-14(28)4-2-10(22)20(37)38/h9-12H,1-8,21-22H2,(H,23,33)(H,24,34)(H,25,27)(H,26,28)(H,29,30)(H,31,32)(H,35,36)(H,37,38)/p-2/t9-,10-,11-,12-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00125 EHMN_ABBREVIATION: C00127
is: CHEBI:58297
boundary condition: false
has only substance units: false
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110061#_38a7b3fe_8a8f_49d9_a1d0_cd7c953f1d95
has only substance units: false
name: TYMP
constant: false
is: P19971
is: SBO:0000252
boundary condition: true
initial concentration: NaN
type: Species
initial amount: NaN
is encoded by: hsa:1890

metaR PROSTGE2t
product: MODEL1310110061#
notes: GENE_ASSOCIATION: (28231.1) or (6578.1) or (28232.1) or (6579.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12507753,PMID:8787677,PMID:9334206 NOTES:NJ
type: Reaction
reversible: true
modifier: MODEL1310110061#
fast: false
kinetic law: MODEL1310110061#
reactant: MODEL1310110061#
name: prostaglandin transport via bicarbonate countertransport
is described by: ECO:0000269
is: SBO:0000185

metaR PYDXtr
product: MODEL1310110061#
type: Reaction
is: SBO:0000185
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:6380540 NOTES:IT
reversible: true
kinetic law: MODEL1310110061#
fast: false
name: Pyridoxal transport
reactant: MODEL1310110061#

metaM pe hs r
initial concentration: 1.0
is: CHEBI:16038
is: SBO:0000247
initial amount: NaN
name: phosphatidylethanolamine
boundary condition: false
constant: false
notes: FORMULA: C5H12NO4PFULLRCO2FULLR2CO2 CHARGE: 0
has only substance units: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110061#_5a77b126_8da9_414c_982a_c2c9772b7619
initial concentration: NaN
initial amount: NaN
type: Species
is encoded by: hsa:39
is: SBO:0000252
has only substance units: false
is: Q9BWD1
boundary condition: true
constant: false
name: ACAT2

metaR r1167
kinetic law: MODEL1310110061#
is described by: ECO:0000000
reversible: false
name: EC:2.3.1.26
is: SBO:0000176
reactant: MODEL1310110061#
type: Reaction
product: MODEL1310110061#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 2.3.1.26 Confidence Level: 0 AUTHORS: PMID:2760547,PMID:7822296,PMID:9242919 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110061#_b7b4e6cc_c86c_40a6_ba55_d1690b35ff26
has only substance units: false
is: O95498
initial amount: NaN
is: SBO:0000252
initial concentration: NaN
name: VNN2
constant: false
boundary condition: true
is encoded by: hsa:8875
type: Species

metaR O2tm
reversible: true
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 1 AUTHORS: PMID:2551143 NOTES:IF
product: MODEL1310110061#
is described by: ECO:0000000
is: SBO:0000185
kinetic law: MODEL1310110061#
fast: false
reactant: MODEL1310110061#
name: O2 transport (diffusion)

metaR r1627
product: MODEL1310110061#
reactant: MODEL1310110061#
is described by: ECO:0000000
type: Reaction
kinetic law: MODEL1310110061#
fast: false
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reversible: true

metaM tddedi2coa m
initial concentration: 1.0
constant: false
has only substance units: false
type: Species
is: SBO:0000247
name: trans2,6dodecadienoylcoa
boundary condition: false
notes: FORMULA: C33H50N7O17P3S CHARGE: -4
initial amount: NaN
is: HMDB06522

http://identifiers.org/biomodels.db/MODEL1310110061#_0c8cf324_69c9_44b7_857e_c78d068ca6b1
has part: P42336
is encoded by: hsa:5296
is encoded by: hsa:5290
type: Species
has part: O00459
boundary condition: true
initial concentration: NaN
name: PIK3CA:PIK3R2
is: SBO:0000297
initial amount: NaN
has only substance units: false
constant: false

metaR Uritn
reactant: MODEL1310110061#
reversible: true
product: MODEL1310110061#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: NOTES:IT
kinetic law: MODEL1310110061#
type: Reaction
is described by: ECO:0000000
fast: false
is: SBO:0000185
name: uridine transport in nucleus

metaM co2 r
is: SBO:0000247
is: CHEBI:16526
is: C00011
has only substance units: false
name: CO2
notes: FORMULA: CO2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00021 EHMN_ABBREVIATION: C00011
constant: false
initial concentration: 1.0
is: HMDB01967
boundary condition: false
initial amount: NaN
type: Species

metaM ptrc c
boundary condition: false
notes: FORMULA: C4H14N2 CHARGE: 2 HEPATONET_1.0_ABBREVIATION: HC00132 EHMN_ABBREVIATION: C00134
type: Species
initial concentration: 1.0
has only substance units: false
is: HMDB01414
name: Putrescine
is: CHEBI:326268
is: C00134
initial amount: NaN
is: SBO:0000247
constant: false

metaM dag hs n
has only substance units: false
boundary condition: false
is: SBO:0000247
is: CHEBI:18035
type: Species
constant: false
notes: FORMULA: C3H6OFULLRCO2FULLR2CO2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC02055
initial amount: NaN
initial concentration: 1.0
name: diglyceride

metaM pydx e
is: C00250
boundary condition: false
has only substance units: false
is: CHEBI:17310
initial concentration: 1.0
name: Pyridoxal
is: HMDB01545
constant: false
notes: FORMULA: C8H9NO3 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00227 EHMN_ABBREVIATION: C00250
initial amount: NaN
type: Species
is: SBO:0000247

metaM tmndnc c
type: Species
name: timnodonic acid C20:5, n-3
initial concentration: 1.0
has only substance units: false
boundary condition: false
is: http://identifiers.org/pubchem.compound/446284
is: SBO:0000247
constant: false
is: HMDB01999
initial amount: NaN
notes: FORMULA: C20H29O2 CHARGE: -1 INCHI: InChI=1/C20H30O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20(21)22/h3-4,6-7,9-10,12-13,15-16H,2,5,8,11,14,17-19H2,1H3,(H,21,22)/b4-3-,7-6-,10-9-,13-12-,16-15-

metaM gluala e
name: 5-L-Glutamyl-L-alanine
has only substance units: false
constant: false
boundary condition: false
is: SBO:0000247
type: Species
is: C03740
is: HMDB06248
initial concentration: 1.0
initial amount: NaN
is: http://identifiers.org/pubchem.compound/6503
notes: FORMULA: C8H13N2O5 CHARGE: -1 INCHI: InChI=1/C8H14N2O5/c1-4(7(12)13)10-6(11)3-2-5(9)8(14)15/h4-5H,2-3,9H2,1H3,(H,10,11)(H,12,13)(H,14,15)/t4-,5-/m0/s1 EHMN_ABBREVIATION: C03740

http://identifiers.org/biomodels.db/MODEL1310110061#_9a8e5df4_fbaf_4db1_b83b_9f40412c3bad
is: SBO:0000252
constant: false
initial concentration: NaN
initial amount: NaN
type: Species
is: O60547
is encoded by: hsa:2762
boundary condition: true
name: GMDS
has only substance units: false

metaM pail345p hs c
has only substance units: false
constant: false
notes: FORMULA: C9H13O18P4FULLRCO2FULLR2CO2 CHARGE: -7 EHMN_ABBREVIATION: C05981
initial amount: NaN
boundary condition: false
is: SBO:0000247
type: Species
name: 1-phosphatidyl-1D-myo-inositol 3,4,5-trisphosphate(7-)
is: CHEBI:57836
initial concentration: 1.0

metaM citr L e
name: citr_L[e]
constant: false
notes: FORMULA: C6H13N3O3 CHARGE: 0 INCHI: InChI=1S/C6H13N3O3/c7-4(5(10)11)2-1-3-9-6(8)12/h4H,1-3,7H2,(H,10,11)(H3,8,9,12)/t4-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00277
boundary condition: false
is: CHEBI:16349
initial amount: NaN
is: SBO:0000247
initial concentration: 1.0
is: HMDB00904
has only substance units: false
type: Species

metaR RETNt
is described by: ECO:0000000
fast: false
product: MODEL1310110061#
reactant: MODEL1310110061#
is: SBO:0000185
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:8630327 NOTES:IT
kinetic law: MODEL1310110061#
name: retinoic acid transport
reversible: true

metaR r0998
product: MODEL1310110061#
fast: false
kinetic law: MODEL1310110061#
reactant: MODEL1310110061#
is described by: ECO:0000000
is: SBO:0000185
name: Facilitated diffusion
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:1735445,PMID:18406340,PMID:1988962,PMID:2351134,PMID:2355017,PMID:6361812,PMID:7892212,PMID:8132483 NOTES:
type: Reaction

metaM hcys L c
is: SBO:0000247
has only substance units: false
constant: false
initial amount: NaN
initial concentration: 1.0
type: Species
is: CHEBI:17588
boundary condition: false
name: L-homocysteine
notes: FORMULA: C4H9NO2S CHARGE: 0 INCHI: InChI=1S/C4H9NO2S/c5-3(1-2-8)4(6)7/h3,8H,1-2,5H2,(H,6,7)/t3-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00151
is: HMDB00742

metaM btn m
boundary condition: false
name: biotinate
constant: false
initial concentration: 1.0
is: HMDB00030
is: CHEBI:57586
initial amount: NaN
has only substance units: false
type: Species
notes: FORMULA: C10H15N2O3S CHARGE: -1 INCHI: InChI=1S/C10H16N2O3S/c13-8(14)4-2-1-3-7-9-6(5-16-7)11-10(15)12-9/h6-7,9H,1-5H2,(H,13,14)(H2,11,12,15)/p-1/t6-,7-,9-/m0/s1 EHMN_ABBREVIATION: C00120
is: SBO:0000247

metaR CYTK14
is: SBO:0000176
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
product: MODEL1310110061#
is version of: http://identifiers.org/ec-code/2.7.4.14
fast: false
is described by: ECO:0000269
modifier: MODEL1310110061#
type: Reaction
name: cytidylate kinase (dCMP,UTP)
kinetic law: MODEL1310110061#
reversible: true
reactant: MODEL1310110061#

http://identifiers.org/biomodels.db/MODEL1310110061#_408cb363_7ac8_4fc5_9bff_3d03f6e04f99
type: Species
boundary condition: true
is: SBO:0000252
initial concentration: NaN
has only substance units: false
constant: false
is encoded by: hsa:23539
is: O95907
name: SLC16A8
initial amount: NaN

metaR PHEt4
product: MODEL1310110061#
type: Reaction
is described by: ECO:0000269
name: L-phenylalanine transport in via sodium symport
reactant: MODEL1310110061#
reversible: false
fast: false
kinetic law: MODEL1310110061#
notes: GENE_ASSOCIATION: (54407.1) or (84889.1) or (11254.1) or (6542.1) or (81539.1) or (6541.1) or (55089.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10747860,PMID:10891391,PMID:10930503,PMID:11325958,PMID:11342143,PMID:11414754,PMID:11591158,PMID:11891586,PMID:12049641,PMID:1348489,PMID:14770310,PMID:7534987,PMID:8954799 NOTES:SAB
is: SBO:0000185
modifier: MODEL1310110061#

metaR GK1
reversible: true
product: MODEL1310110061#
reactant: MODEL1310110061#
name: guanylate kinase (GMP:ATP)
notes: GENE_ASSOCIATION: (2987.1) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: NOTES:
type: Reaction
modifier: MODEL1310110061#
fast: false
kinetic law: MODEL1310110061#
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/2.7.4.8
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110061#_c41307fa_7bae_46d7_a07a_dde26129f2b7
boundary condition: true
is: Q16831
has only substance units: false
constant: false
initial concentration: NaN
name: UPP1
type: Species
is encoded by: hsa:7378
initial amount: NaN
is: SBO:0000252

metaM CE2838 e
name: maltononaose
notes: FORMULA: C54H92O46 CHARGE: 0 INCHI: InChI=1/C54H92O46/c55-1-10-19(64)20(65)30(75)47(85-10)94-39-12(3-57)87-49(32(77)22(39)67)96-41-14(5-59)89-51(34(79)24(41)69)98-43-16(7-61)91-53(36(81)26(43)71)100-45-18(9-63)92-54(37(82)28(45)73)99-44-17(8-62)90-52(35(80)27(44)72)97-42-15(6-60)88-50(33(78)25(42)70)95-40-13(4-58)86-48(31(76)23(40)68)93-38-11(2-56)84-46(83)29(74)21(38)66/h10-83H,1-9H2/t10-,11-,12-,13-,14-,15-,16-,17-,18-,19+,20+,21-,22-,23-,24-,25-,26-,27-,28-,29+,30+,31+,32+,33+,34+,35+,36+,37+,38+,39+,40+,41+,42+,43+,44+,45+,46u,47+,48+,49+,50+,51+,52+,53+,54+/m1/s1 EHMN_ABBREVIATION: CE2838
constant: false
is: http://identifiers.org/pubchem.compound/5041
type: Species
is: C01936
has only substance units: false
initial amount: NaN
boundary condition: false
initial concentration: 1.0
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110061#_07394428_c2c6_489c_ab2c_3638f3b189af
has only substance units: false
constant: false
boundary condition: true
initial amount: NaN
name: ADH1A
initial concentration: NaN
type: Species
is: SBO:0000252
is encoded by: hsa:124
is: P07327

metaR r1628
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reversible: true
fast: false
is: SBO:0000185
product: MODEL1310110061#
reactant: MODEL1310110061#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is described by: ECO:0000000
type: Reaction
kinetic law: MODEL1310110061#

metaR MMMm
reactant: MODEL1310110061#
type: Reaction
notes: GENE_ASSOCIATION: (4594.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 5.4.99.2 Confidence Level: 4 AUTHORS: PMID:8990001 NOTES:TDV
is: SBO:0000176
product: MODEL1310110061#
name: methylmalonyl-CoA mutase
modifier: MODEL1310110061#
fast: false
is described by: ECO:0000269
reversible: true
kinetic law: MODEL1310110061#
is version of: http://identifiers.org/ec-code/5.4.99.2

metaR GRTTx
name: geranyltranstransferase
is version of: http://identifiers.org/ec-code/2.5.1.1
is described by: ECO:0000134
product: MODEL1310110061#
reversible: false
is: SBO:0000176
modifier: MODEL1310110061#
reactant: MODEL1310110061#
notes: GENE_ASSOCIATION: (2224.1) SUBSYSTEM: Cholesterol metabolism EC Number: 2.5.1.10 Confidence Level: 4 AUTHORS: PMID:8188698 NOTES:peroxisomal version - NJ
fast: false
type: Reaction
kinetic law: MODEL1310110061#

metaR OMPDC
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/2.4.2.10
kinetic law: MODEL1310110061#
reactant: MODEL1310110061#
name: orotidine-5'-phosphate decarboxylase
fast: false
reversible: false
modifier: MODEL1310110061#
is: SBO:0000176
product: MODEL1310110061#
type: Reaction
notes: GENE_ASSOCIATION: (7372.1) SUBSYSTEM: Pyrimidine synthesis EC Number: 4.1.1.23 Confidence Level: 4 AUTHORS: PMID:3279416,PMID:6574608,PMID:6893554,PMID:9042911 NOTES:

metaM HC02187 c
type: Species
has only substance units: false
boundary condition: false
name: reverse-triiodthyronine
constant: false
is: CHEBI:28774
is: SBO:0000247
initial amount: NaN
initial concentration: 1.0
notes: FORMULA: C15H12I3NO4 CHARGE: 0 INCHI: InChI=1S/C15H12I3NO4/c16-9-3-7(4-12(19)15(21)22)1-2-13(9)23-8-5-10(17)14(20)11(18)6-8/h1-3,5-6,12,20H,4,19H2,(H,21,22)

metaR r2079
reactant: MODEL1310110061#
type: Reaction
is described by: ECO:0000000
modifier: MODEL1310110061#
reversible: true
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
kinetic law: MODEL1310110061#
is: SBO:0000185
product: MODEL1310110061#
fast: false

http://identifiers.org/biomodels.db/MODEL1310110061#_611eed4a_1d63_4928_928e_15a74fffa8eb
name: GCK
has only substance units: false
constant: false
initial concentration: NaN
is encoded by: hsa:2645
type: Species
initial amount: NaN
is: SBO:0000252
is: P35557
boundary condition: true

metaR SERALANaEx
kinetic law: MODEL1310110061#
type: Reaction
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (6509.1) or (6510.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14530974 NOTES:SAB see Kanai and Hediger 2004 (2003), PMID 14530974
is: SBO:0000185
modifier: MODEL1310110061#
name: L-alanine/L-serine Na-dependent exchange (Ser-L in)
fast: false
product: MODEL1310110061#
reversible: false
reactant: MODEL1310110061#

metaM ptrc e
is: C00134
notes: FORMULA: C4H14N2 CHARGE: 2 HEPATONET_1.0_ABBREVIATION: HC00132 EHMN_ABBREVIATION: C00134
constant: false
is: SBO:0000247
type: Species
is: HMDB01414
has only substance units: false
initial concentration: 1.0
is: CHEBI:326268
boundary condition: false
name: Putrescine
initial amount: NaN

metaM Ser Thr l
is: C05606
has only substance units: false
is: SBO:0000247
is: HMDB04068
boundary condition: false
notes: FORMULA: XH CHARGE: 0
constant: false
name: protein-linked serine or threonine residue (O-glycosylation site)
type: Species
initial amount: NaN
is: http://identifiers.org/pubchem.compound/7929
initial concentration: 1.0

metaR DESAT18 10
reversible: false
type: Reaction
name: fatty acyl-CoA desaturase (n-C18:2CoA -> n-C18:3CoA)
is described by: ECO:0000000
fast: false
kinetic law: MODEL1310110061#
product: MODEL1310110061#
modifier: MODEL1310110061#
reactant: MODEL1310110061#
notes: GENE_ASSOCIATION: (9415.1) SUBSYSTEM: Fatty acid synthesis EC Number: 1.14.19.1 Confidence Level: 4 AUTHORS: NOTES:for homo sapiens, noted to actually be NADH-cyt b5, using NADH at present NJ
is: SBO:0000176

metaM forglu c
notes: FORMULA: C6H8N2O4 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00357 EHMN_ABBREVIATION: C00439
initial amount: NaN
type: Species
boundary condition: false
is: HMDB00854
initial concentration: 1.0
is: CHEBI:18327
is: C00439
is: SBO:0000247
constant: false
has only substance units: false
name: N-Formimidoyl-L-glutamate

metaR ESTRADIOLtr
product: MODEL1310110061#
kinetic law: MODEL1310110061#
fast: false
name: estradiol intracellular transport
reversible: true
is described by: ECO:0000000
reactant: MODEL1310110061#
type: Reaction
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: NOTES:specific mechanism not known, proton dependence for trans-mit transport has been suggested, however directionality and stoichiometry has not yet been elucidated. see PMID: 12770731 and others NJ

metaR r0456
notes: GENE_ASSOCIATION: (AA614647.1) or (1120.1) or (1374.1) or (1375.1) or (126129.1) or (1376.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.1.113 Confidence Level: 0 AUTHORS: PMID:15748706 NOTES:
is version of: http://identifiers.org/ec-code/2.3.1.21
reversible: false
name: ATP:deoxyguanosine 5-phosphotransferase Purine metabolism EC:2.7.1.113
reactant: MODEL1310110061#
fast: false
is described by: ECO:0000000
kinetic law: MODEL1310110061#
is: SBO:0000176
modifier: MODEL1310110061#
type: Reaction
is version of: http://identifiers.org/ec-code/2.7.1.32
product: MODEL1310110061#

metaR 34HPLFM
reversible: false
name: 3-(4-hydroxyphenyl-)lactate formation
fast: false
is: SBO:0000176
product: MODEL1310110061#
reactant: MODEL1310110061#
is described by: ECO:0000000
type: Reaction
kinetic law: MODEL1310110061#
notes: GENE_ASSOCIATION: SUBSYSTEM: Ubiquinone synthesis EC Number: Confidence Level: 2 AUTHORS: PMID:11583838,PMID:12232327 NOTES:IT reaction involved in formation of 4-hydroxybenzoate from tyrosine.

http://identifiers.org/biomodels.db/MODEL1310110061#_5dc95e9b_3473_4396_bf36_f1b34a4e84c3
is: Q16795
is: SBO:0000252
boundary condition: true
initial concentration: NaN
has only substance units: false
type: Species
constant: false
is encoded by: hsa:4704
name: NDUFA9
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110061#_195b6ec0_1053_4cf2_87f7_c824958bcfb1
initial amount: NaN
type: Species
boundary condition: true
is encoded by: hsa:50
name: ACO2
initial concentration: NaN
is: Q99798
has only substance units: false
constant: false
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110061#_0b11feb0_99fe_4469_8ca8_b70fd494db84
constant: false
boundary condition: true
initial concentration: NaN
is encoded by: hsa:1339
has only substance units: false
is: SBO:0000252
name: COX6A2
is: Q02221
type: Species
initial amount: NaN

metaR r2327
reversible: true
kinetic law: MODEL1310110061#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
fast: false
is: SBO:0000185
product: MODEL1310110061#
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
reactant: MODEL1310110061#
type: Reaction

metaR EX h2o2 LPAREN e RPAREN
kinetic law: MODEL1310110061#
reactant: MODEL1310110061#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Hydrogen peroxide exchange
type: Reaction

metaR r1589
reactant: MODEL1310110061#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
product: MODEL1310110061#
is: SBO:0000185
type: Reaction
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
kinetic law: MODEL1310110061#
is described by: ECO:0000000
fast: false

metaM dhcholestanate m
notes: FORMULA: C27H45O4 CHARGE: -1 INCHI: InChI=1S/C27H46O4/c1-16(6-5-7-17(2)25(30)31)20-8-9-21-24-22(11-13-27(20,21)4)26(3)12-10-19(28)14-18(26)15-23(24)29/h16-24,28-29H,5-15H2,1-4H3,(H,30,31)/t16-,17?,18+,19-,20-,21+,22+,23-,24+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01313 EHMN_ABBREVIATION: C04554
initial concentration: 1.0
initial amount: NaN
has only substance units: false
is: SBO:0000247
type: Species
name: 3alpha,7alpha-Dihydroxy-5beta-cholestanate
is: CHEBI:16577
is: HMDB00359
constant: false
boundary condition: false

metaR r0611
reversible: true
kinetic law: MODEL1310110061#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (316.1) SUBSYSTEM: Unassigned EC Number: 2.7.1.11 Confidence Level: 0 AUTHORS: PMID:131802,PMID:1810251 NOTES:
is version of: http://identifiers.org/ec-code/1.2.3.1
name: ITP:D-Tagatose 6-phosphate 1-phosphotransferase Galactose metabolism EC:2.7.1.11
type: Reaction
fast: false
is: SBO:0000176
product: MODEL1310110061#
reactant: MODEL1310110061#
modifier: MODEL1310110061#

http://identifiers.org/biomodels.db/MODEL1310110061#_bca8d174_bd39_48cc_b0c4_e09fbf229c54
name: B3GALT5
is encoded by: hsa:10317
is: SBO:0000252
boundary condition: true
type: Species
constant: false
initial amount: NaN
is: Q9Y2C3
has only substance units: false
initial concentration: NaN

metaR r0545
modifier: MODEL1310110061#
reversible: true
reactant: MODEL1310110061#
fast: false
is described by: ECO:0000000
kinetic law: MODEL1310110061#
is: SBO:0000176
name: Phenylacetaldehyde:NAD+ oxidoreductase Phenylalanine metabolism / Styrene degradation EC:1.2.1.5 EC:1.2.1.39
product: MODEL1310110061#
is version of: http://identifiers.org/ec-code/3.6.1.5
notes: GENE_ASSOCIATION: (AV717590.1) or (953.1) or (956.1) or (377841.1) SUBSYSTEM: Phenylalanine metabolism EC Number: 1.2.1.5 Confidence Level: 0 AUTHORS: PMID:15230339 NOTES:
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110061#_b7125b00_051f_4369_bc15_67007b29ef67
boundary condition: true
name: SLC40A1
has only substance units: false
is: SBO:0000252
type: Species
initial amount: NaN
constant: false
initial concentration: NaN
is encoded by: hsa:30061
is: Q9NP59

http://identifiers.org/biomodels.db/MODEL1310110061#_6b113068_2768_4400_a1c2_42b66f7e50f6
initial concentration: NaN
constant: false
is encoded by: hsa:6391
type: Species
boundary condition: true
is: SBO:0000252
name: SDHC
has only substance units: false
initial amount: NaN
is: Q99643

metaM 10fthf m
is: HMDB00972
is: CHEBI:57454
boundary condition: false
is: SBO:0000247
notes: FORMULA: C20H21N7O7 CHARGE: -2 INCHI: InChI=1S/C20H23N7O7/c21-20-25-16-15(18(32)26-20)23-11(7-22-16)8-27(9-28)12-3-1-10(2-4-12)17(31)24-13(19(33)34)5-6-14(29)30/h1-4,9,11,13,23H,5-8H2,(H,24,31)(H,29,30)(H,33,34)(H4,21,22,25,26,32)/p-2/t11-,13+/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00212 EHMN_ABBREVIATION: C00234
name: 10-formyltetrahydrofolate(2-)
type: Species
has only substance units: false
initial amount: NaN
constant: false
initial concentration: 1.0

metaR ANTHte
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
reactant: MODEL1310110061#
name: Transport of anthranilate
reversible: true
type: Reaction
fast: false
is described by: ECO:0000134
product: MODEL1310110061#
kinetic law: MODEL1310110061#
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110061#_95df7a82_73eb_45ed_a7ef_1179248ef36a
initial concentration: NaN
is: Q38G75
initial amount: NaN
has only substance units: false
boundary condition: true
type: Species
constant: false
is encoded by: hsa:2582
name: GALE
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110061#_9a3c40a6_d028_444d_9b69_ebb737e53bca
is encoded by: hsa:3948
constant: false
has only substance units: false
boundary condition: true
name: LDHC
type: Species
initial amount: NaN
is: SBO:0000252
initial concentration: NaN

metaR O2tp
kinetic law: MODEL1310110061#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD
is: SBO:0000185
name: O2 transport, peroxisomal
reversible: true
is described by: ECO:0000000
fast: false
reactant: MODEL1310110061#
product: MODEL1310110061#
type: Reaction

metaR GTHOm
reactant: MODEL1310110061#
type: Reaction
notes: GENE_ASSOCIATION: (2936.1) SUBSYSTEM: Glutamate metabolism EC Number: 1.8.1.7 Confidence Level: 2 AUTHORS: PMID:10708558,PMID:15149466 NOTES:NCD, TV This EC (1.6.4.2) is obsolete. The new EC is 1.8.1.7. http://www.genome.ad.jp/dbget-bin/www_bget?ec:1.6.4.2
is version of: http://identifiers.org/ec-code/1.8.1.7
is: SBO:0000176
fast: false
reversible: false
product: MODEL1310110061#
is described by: ECO:0000254
name: glutathione oxidoreductase
kinetic law: MODEL1310110061#
modifier: MODEL1310110061#

metaR r2326
is described by: ECO:0000000
fast: false
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
kinetic law: MODEL1310110061#
product: MODEL1310110061#
reactant: MODEL1310110061#
type: Reaction
is: SBO:0000185

metaR TREHe
modifier: MODEL1310110061#
fast: false
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (11181.1) SUBSYSTEM: Starch and sucrose metabolism EC Number: 3.2.1.28 Confidence Level: 4 AUTHORS: PMID:12065209,PMID:9427547 NOTES:JLR
product: MODEL1310110061#
type: Reaction
is: SBO:0000176
kinetic law: MODEL1310110061#
reversible: false
name: alpha,alpha-trehalase
is version of: http://identifiers.org/ec-code/3.2.1.28
reactant: MODEL1310110061#

metaM 3php c
has only substance units: false
constant: false
name: 3-phosphonatooxypyruvate(3-)
is: CHEBI:18110
notes: FORMULA: C3H2O7P CHARGE: -3 INCHI: InChI=1S/C3H5O7P/c4-2(3(5)6)1-10-11(7,8)9/h1H2,(H,5,6)(H2,7,8,9)/p-3 HEPATONET_1.0_ABBREVIATION: HC01082 EHMN_ABBREVIATION: C03232
is: SBO:0000247
initial concentration: 1.0
is: HMDB01024
boundary condition: false
type: Species
initial amount: NaN

metaR r1487
is: SBO:0000176
type: Reaction
fast: false
is described by: ECO:0000000
reactant: MODEL1310110061#
reversible: true
kinetic law: MODEL1310110061#
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 0 AUTHORS: PMID:8584017 NOTES:
name: EC:6.2.1.3
product: MODEL1310110061#

http://identifiers.org/biomodels.db/MODEL1310110061#_98965ac8_5f0a_44de_b16d_39a71f031e0e
constant: false
name: CA12
initial amount: NaN
initial concentration: NaN
has only substance units: false
is encoded by: hsa:771
boundary condition: true
is: SBO:0000252
is: O43570
type: Species

metaM pail35p hs c
notes: FORMULA: C9H14O15P3FULLRCO2FULLR2CO2 CHARGE: -5
is: SBO:0000247
name: 1-phosphatidyl-1D-myo-inositol 3,5-bisphosphate(5-)
has only substance units: false
initial concentration: 1.0
constant: false
type: Species
is: CHEBI:57923
boundary condition: false
initial amount: NaN

metaM gdpfuc c
name: GDP-L-fucose(2-)
initial concentration: 1.0
initial amount: NaN
boundary condition: false
is: HMDB01095
is: SBO:0000247
constant: false
has only substance units: false
type: Species
notes: FORMULA: C16H23N5O15P2 CHARGE: -2 INCHI: InChI=1S/C16H25N5O15P2/c1-4-7(22)9(24)11(26)15(33-4)35-38(30,31)36-37(28,29)32-2-5-8(23)10(25)14(34-5)21-3-18-6-12(21)19-16(17)20-13(6)27/h3-5,7-11,14-15,22-26H,2H2,1H3,(H,28,29)(H,30,31)(H3,17,19,20,27)/p-2/t4-,5+,7+,8+,9+,10+,11-,14+,15?/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00275 EHMN_ABBREVIATION: C00325
is: CHEBI:57984

metaM glc D g
initial concentration: 1.0
boundary condition: false
is: CHEBI:4167
is: HMDB00122
has only substance units: false
name: D-glucose
is: SBO:0000247
type: Species
constant: false
initial amount: NaN
notes: FORMULA: C6H12O6 CHARGE: 0 INCHI: InChI=1S/C6H12O6/c7-1-2-3(8)4(9)5(10)6(11)12-2/h2-11H,1H2/t2-,3-,4+,5-,6?/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00040

metaR r1588
is: SBO:0000185
kinetic law: MODEL1310110061#
is described by: ECO:0000000
reactant: MODEL1310110061#
product: MODEL1310110061#
fast: false
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
type: Reaction
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:

metaM prostgd2 c
notes: FORMULA: C20H31O5 CHARGE: -1 INCHI: InChI=1S/C20H32O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h4,7,12-13,15-18,21-22H,2-3,5-6,8-11,14H2,1H3,(H,24,25)/p-1/b7-4-,13-12+/t15-,16+,17+,18-/m0/s1 EHMN_ABBREVIATION: C00696
is: HMDB01403
constant: false
is: CHEBI:57406
name: prostaglandin D2(1-)
boundary condition: false
is: SBO:0000247
type: Species
initial amount: NaN
initial concentration: 1.0
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110061#_a24c034e_dce0_4318_9993_5a8a221c3cbd
constant: false
initial amount: NaN
is: SBO:0000252
is encoded by: hsa:27068
name: PPA2
boundary condition: true
has only substance units: false
type: Species
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110061#_ac25ad91_78dc_4f3b_9bf6_917794b6733b
initial amount: NaN
is: SBO:0000252
has only substance units: false
type: Species
is encoded by: hsa:8879
initial concentration: NaN
constant: false
is: O95470
name: SGPL1
boundary condition: true

metaR GPDDA1
kinetic law: MODEL1310110061#
product: MODEL1310110061#
name: Glycerophosphodiester phosphodiesterase (Glycerophosphocholine)
is: SBO:0000176
type: Reaction
reversible: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Glycerophospholipid metabolism EC Number: 3.1.4.46 Confidence Level: 0 AUTHORS: NOTES:JLR
fast: false
reactant: MODEL1310110061#
is described by: ECO:0000000

metaR GAPD
notes: GENE_ASSOCIATION: (2597.1) or (26330.1) SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: 1.2.1.12 Confidence Level: 0 AUTHORS: PMID:10714828 NOTES:SMP. Same reaction as GAPDH, but localied to spermatids. NOTE: I think "glyceroyl" in this and many other reactions should be "glycerol". There are "glyceroyl" compounds, but I don't think that is what is intended here.
is: SBO:0000176
product: MODEL1310110061#
kinetic law: MODEL1310110061#
fast: false
reversible: true
name: glyceraldehyde-3-phosphate dehydrogenase
modifier: MODEL1310110061#
reactant: MODEL1310110061#
type: Reaction
is described by: ECO:0000134
is version of: http://identifiers.org/ec-code/1.2.1.12

http://identifiers.org/biomodels.db/MODEL1310110061#_7ba8c84a_7967_4436_91e6_18be9317fbc6
initial concentration: NaN
constant: false
type: Species
is: SBO:0000252
is: Q9Y6K8
name: AK5
has only substance units: false
is encoded by: hsa:26289
initial amount: NaN
boundary condition: true

metaM thyox L e
is: HMDB00248
notes: FORMULA: C15H11I4NO4 CHARGE: 0 INCHI: InChI=1S/C15H11I4NO4/c16-8-4-7(5-9(17)13(8)21)24-14-10(18)1-6(2-11(14)19)3-12(20)15(22)23/h1-2,4-5,12,21H,3,20H2,(H,22,23)/t12-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00849
constant: false
type: Species
boundary condition: false
is: SBO:0000247
has only substance units: false
name: L-thyroxine
initial amount: NaN
initial concentration: 1.0
is: CHEBI:18332

metaM sphgn c
has only substance units: false
type: Species
initial concentration: 1.0
name: sphinganine(1+)
is: SBO:0000247
boundary condition: false
notes: FORMULA: C18H40NO2 CHARGE: 1 INCHI: InChI=1S/C18H39NO2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-18(21)17(19)16-20/h17-18,20-21H,2-16,19H2,1H3/p+1/t17-,18+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00556 EHMN_ABBREVIATION: C00836
is: CHEBI:57817
constant: false
initial amount: NaN
is: HMDB00269

http://identifiers.org/biomodels.db/MODEL1310110061#_1b01832d_d53c_4c71_9a57_0b38d8113cd2
has only substance units: false
type: Species
boundary condition: true
initial amount: NaN
name: DGKQ
is: SBO:0000252
constant: false
initial concentration: NaN
is: P52824
is encoded by: hsa:1609

metaR CERT2rt
name: ceramide transport protein
is version of: http://identifiers.org/ec-code/2.7.11.1
is described by: ECO:0000000
is: SBO:0000185
notes: GENE_ASSOCIATION: (10087.1) SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: PMID:12803919,PMID:14685229,PMID:15596449,PMID:15907394 NOTES:non-vesicular intracellular transport of glucocerebroside
kinetic law: MODEL1310110061#
fast: false
reactant: MODEL1310110061#
modifier: MODEL1310110061#
product: MODEL1310110061#
type: Reaction
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110061#_92112845_8580_4b28_9a7a_1211c971e6d0
type: Species
initial concentration: NaN
initial amount: NaN
constant: false
is: SBO:0000252
has only substance units: false
name: _D29675_1_e
is encoded by: hsa:D29675
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110061#_72d8133e_3bd3_4f90_8d5c_eadd4c1181c4
type: Species
has only substance units: false
is: SBO:0000252
initial amount: NaN
is: P48651
boundary condition: true
name: PTDSS1
is encoded by: hsa:9791
constant: false
initial concentration: NaN

metaM HC02202 c
has only substance units: false
initial amount: NaN
initial concentration: 1.0
notes: FORMULA: C20H31O4 CHARGE: -1 INCHI: InChI=1S/C20H32O4/c1-2-3-6-9-17(21)14-12-16-13-15-19(22)18(16)10-7-4-5-8-11-20(23)24/h12-18,21H,2-11H2,1H3,(H,23,24)/p-1/b14-12+/t16-,17-,18+/m0/s1 EHMN_ABBREVIATION: C04685
boundary condition: false
is: CHEBI:57398
name: prostaglandin A1(1-)
type: Species
constant: false
is: SBO:0000247

metaR PSDm hs
product: MODEL1310110061#
fast: false
reversible: false
is: SBO:0000176
kinetic law: MODEL1310110061#
modifier: MODEL1310110061#
is described by: ECO:0000269
name: Phosphatidylserine decarboxylase
type: Reaction
is version of: http://identifiers.org/ec-code/4.1.1.65
notes: GENE_ASSOCIATION: (23761.1) SUBSYSTEM: Glycerophospholipid metabolism EC Number: 4.1.1.65 Confidence Level: 4 AUTHORS: PMID:15052331,PMID:9370338 NOTES:modified from TV version for hs NJ
reactant: MODEL1310110061#

metaR MI1345PP
modifier: MODEL1310110061#
notes: GENE_ASSOCIATION: (3635.1) or (8867.2) or (3636.1) or (27124.2) or (8867.1) or (27124.1) or (3633.1) or (56623.1) or (3632.1) SUBSYSTEM: Inositol phosphate metabolism EC Number: 3.1.3.56 Confidence Level: 4 AUTHORS: PMID:10593988,PMID:10764818,PMID:15261714,PMID:2906139,PMID:7721860,PMID:8006039,PMID:8013665,PMID:8530088,PMID:8769125,PMID:9428629,PMID:9824312 NOTES:NCD
product: MODEL1310110061#
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/3.1.3.36
type: Reaction
is: SBO:0000176
reactant: MODEL1310110061#
is version of: http://identifiers.org/ec-code/3.1.3.86
is version of: http://identifiers.org/ec-code/3.1.3.56
kinetic law: MODEL1310110061#
fast: false
name: inositol-1,3,4,5-trisphosphate 5-phosphatase
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110061#_f8846970_9ed3_45f7_8e49_a207d0133ac9
name: BDH1
initial concentration: NaN
type: Species
has only substance units: false
constant: false
initial amount: NaN
boundary condition: true
is encoded by: hsa:622
is: SBO:0000252

metaR RE2626C
kinetic law: MODEL1310110061#
name: RE2626
is described by: ECO:0000000
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Bile acid synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:9210654,PMID:9660774 NOTES:
product: MODEL1310110061#
reactant: MODEL1310110061#
fast: false
is: SBO:0000176
reversible: true

metaR EX CE1926 LPAREN e RPAREN
kinetic law: MODEL1310110061#
reactant: MODEL1310110061#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: gama-carboxyethyl-hydroxychroman exchange
type: Reaction

metaR r2329
is described by: ECO:0000000
reversible: true
kinetic law: MODEL1310110061#
is: SBO:0000185
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
product: MODEL1310110061#
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
reactant: MODEL1310110061#
type: Reaction

metaR EX tdchola LPAREN e RPAREN
kinetic law: MODEL1310110061#
reactant: MODEL1310110061#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: taurochenodeoxycholate exchange
type: Reaction

metaR RE1807M
notes: GENE_ASSOCIATION: (1593.1) SUBSYSTEM: Bile acid synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:9660774 NOTES:
fast: false
is described by: ECO:0000000
reversible: true
kinetic law: MODEL1310110061#
product: MODEL1310110061#
is version of: http://identifiers.org/ec-code/1.14.13.15
modifier: MODEL1310110061#
is: SBO:0000176
reactant: MODEL1310110061#
name: RE1807
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110061#_12168e80_0aee_43e0_8cd0_13e777cb3b09
name: SLC24A4
is: SBO:0000252
is encoded by: hsa:123041
initial amount: NaN
boundary condition: true
has only substance units: false
type: Species
initial concentration: NaN
constant: false

metaM methf m
initial concentration: 1.0
initial amount: NaN
name: (6R)-5,10-methenyltetrahydrofolate
has only substance units: false
constant: false
is: SBO:0000247
notes: FORMULA: C20H20N7O6 CHARGE: -1 INCHI: InChI=1S/C20H21N7O6/c21-20-24-16-15(18(31)25-20)27-9-26(8-12(27)7-22-16)11-3-1-10(2-4-11)17(30)23-13(19(32)33)5-6-14(28)29/h1-4,9,12-13H,5-8H2,(H6-,21,22,23,24,25,28,29,30,31,32,33)/p-1/t12-,13+/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00360 EHMN_ABBREVIATION: C00445
is: HMDB01354
is: CHEBI:57455
boundary condition: false
type: Species

metaM frdp r
name: Farnesyl diphosphate
initial concentration: 1.0
is: SBO:0000247
initial amount: NaN
is: HMDB00961
type: Species
boundary condition: false
notes: FORMULA: C15H25O7P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00362 EHMN_ABBREVIATION: C00448
has only substance units: false
is: CHEBI:175763
constant: false
is: C00448

metaR RTOTAL2t
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:14598172 NOTES:
name: RTOTAL2 transport
type: Reaction
is described by: ECO:0000000
kinetic law: MODEL1310110061#
product: MODEL1310110061#
is: SBO:0000185
reversible: true
reactant: MODEL1310110061#

metaR r0345
is: SBO:0000176
type: Reaction
modifier: MODEL1310110061#
fast: false
name: ATP:AMP phosphotransferase Purine metabolism EC:2.7.4.11
is version of: http://identifiers.org/ec-code/1.3.99.3
reversible: true
kinetic law: MODEL1310110061#
notes: GENE_ASSOCIATION: (27034.1) or (28976.1) or (33.1) or (34.1) or (37.1) or (51.1) or (8310.1) or (AI285872.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.11 Confidence Level: 0 AUTHORS: PMID:11768308 NOTES:
product: MODEL1310110061#
is version of: http://identifiers.org/ec-code/1.3.3.6
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/1.3.99.13
reactant: MODEL1310110061#

metaR EX tchola LPAREN e RPAREN
kinetic law: MODEL1310110061#
reactant: MODEL1310110061#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Taurocholic acid exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110061#_2d1f4cb2_662e_47b6_8707_0061f3db82e3
initial concentration: NaN
is: P08195
type: Species
boundary condition: true
is: SBO:0000252
is encoded by: hsa:6520
initial amount: NaN
name: SLC3A2
constant: false
has only substance units: false

metaR XANDp
is version of: http://identifiers.org/ec-code/1.17.1.4
fast: false
kinetic law: MODEL1310110061#
type: Reaction
modifier: MODEL1310110061#
notes: GENE_ASSOCIATION: (7498.1) SUBSYSTEM: Purine catabolism EC Number: 1.1.1.204 Confidence Level: 4 AUTHORS: PMID:12637268,PMID:8670112 NOTES:Acts on a variety of purines and aldehydes. The animal enzyme can be interconverted to EC 1.1.3.22 xanthine oxidase (the oxidase form). IT
product: MODEL1310110061#
name: xanthine dehydrogenase, peroxisomal
reversible: false
is: SBO:0000176
reactant: MODEL1310110061#
is described by: ECO:0000269

metaM pail3p hs c
initial amount: NaN
boundary condition: false
constant: false
type: Species
has only substance units: false
is: CHEBI:58088
initial concentration: 1.0
is: SBO:0000247
name: 1-phosphatidyl-1D-myo-inositol 3-phosphate(3-)
notes: FORMULA: C9H15O12P2FULLRCO2FULLR2CO2 CHARGE: -3 EHMN_ABBREVIATION: C04549

metaM hdcea e
initial amount: NaN
has only substance units: false
is: CHEBI:32372
is: HMDB03229
notes: FORMULA: C16H29O2 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC01981 EHMN_ABBREVIATION: CE0850
name: Hexadecenoate (n-C16:1)
constant: false
boundary condition: false
initial concentration: 1.0
is: SBO:0000247
type: Species

metaM idp c
name: IDP(3-)
boundary condition: false
initial concentration: 1.0
type: Species
has only substance units: false
initial amount: NaN
notes: FORMULA: C10H11N4O11P2 CHARGE: -3 INCHI: InChI=1S/C10H14N4O11P2/c15-6-4(1-23-27(21,22)25-26(18,19)20)24-10(7(6)16)14-3-13-5-8(14)11-2-12-9(5)17/h2-4,6-7,10,15-16H,1H2,(H,21,22)(H,11,12,17)(H2,18,19,20)/p-3/t4-,6-,7-,10-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00104 EHMN_ABBREVIATION: C00104
is: HMDB03335
is: SBO:0000247
constant: false
is: CHEBI:58280

metaR DASCBR
is version of: http://identifiers.org/ec-code/1.8.4.1
type: Reaction
notes: GENE_ASSOCIATION: (2745.1) or (51022.2) or (51022.1) SUBSYSTEM: Vitamin C metabolism EC Number: 1.6.5.4 Confidence Level: 4 AUTHORS: PMID:11297543 NOTES:
reversible: false
fast: false
modifier: MODEL1310110061#
is described by: ECO:0000269
name: dehydroascorbate reductase
product: MODEL1310110061#
kinetic law: MODEL1310110061#
reactant: MODEL1310110061#
is: SBO:0000176

metaR CLPNDCOAtx
kinetic law: MODEL1310110061#
type: Reaction
fast: false
is described by: ECO:0000000
product: MODEL1310110061#
name: fatty acid intracellular transport
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: NOTES:interaction between peroxisomes and ER (some enzymes on the outer membrane) NJ
is: SBO:0000185
reversible: true
reactant: MODEL1310110061#

metaR CHOLATEt
reactant: MODEL1310110061#
is: SBO:0000185
product: MODEL1310110061#
type: Reaction
reversible: true
is described by: ECO:0000269
kinetic law: MODEL1310110061#
modifier: MODEL1310110061#
fast: false
name: cholate transport via bicarbonate countertransport
notes: GENE_ASSOCIATION: (6579.1) or (10599.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12507753,PMID:9007731,PMID:9334206 NOTES:NJ

http://identifiers.org/biomodels.db/MODEL1310110061#_985d472c_43cb_4f10_a1a1_45efb57b850a
initial amount: NaN
name: ACO1
constant: false
is: P21399
is encoded by: hsa:48
has only substance units: false
initial concentration: NaN
boundary condition: true
is: SBO:0000252
type: Species

http://identifiers.org/biomodels.db/MODEL1310110061#_59769508_910a_43ef_960b_f4d2bcca709b
name: _AI697028_1_m
is encoded by: hsa:AI697028
boundary condition: true
is: SBO:0000252
type: Species
initial amount: NaN
initial concentration: NaN
constant: false
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110061#_7953c354_4e2c_4372_ba02_c459aee47e40
type: Species
has only substance units: false
initial amount: NaN
boundary condition: true
name: _AA081045_1_e
is: SBO:0000252
is encoded by: hsa:AA081045
initial concentration: NaN
constant: false

http://identifiers.org/biomodels.db/MODEL1310110061#_c5b5885c_fcd9_447d_aeb9_e39aca27548d
initial amount: NaN
constant: false
type: Species
name: _100128062_1_m
initial concentration: NaN
has only substance units: false
boundary condition: true
is encoded by: hsa:100128062
is: SBO:0000252

metaR HISCAT1
kinetic law: MODEL1310110061#
product: MODEL1310110061#
reactant: MODEL1310110061#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: Transport of L-Histidine by y+ transporter
type: Reaction

metaM CE4876 r
is: CHEBI:57460
has only substance units: false
notes: FORMULA: C20H29O4 CHARGE: -1 INCHI: InChI=1/C20H30O4/c1-2-3-6-10-17(21)13-14-18-16(12-15-19(18)22)9-7-4-5-8-11-20(23)24/h4,7,12,14-17,21H,2-3,5-6,8-11,13H2,1H3,(H,23,24)/p-1/b7-4-,18-14+/t16-,17-/m0/s1 EHMN_ABBREVIATION: CE4876
is: SBO:0000247
constant: false
name: delta12-Prostaglandin J2
type: Species
initial concentration: 1.0
is: HMDB01509
boundary condition: false
initial amount: NaN

metaR r2328
product: MODEL1310110061#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
reactant: MODEL1310110061#
is: SBO:0000185
fast: false
type: Reaction
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
reversible: true
kinetic law: MODEL1310110061#
is described by: ECO:0000000

metaR r0130
is described by: ECO:0000000
reactant: MODEL1310110061#
modifier: MODEL1310110061#
kinetic law: MODEL1310110061#
name: gamma-glutamyltranspeptidase Glutathione metabolism EC:3.4.11.4
reversible: true
fast: false
is: SBO:0000176
product: MODEL1310110061#
type: Reaction
notes: GENE_ASSOCIATION: (LOC374569.1) SUBSYSTEM: Glutathione metabolism EC Number: 3.4.11.4 Confidence Level: 0 AUTHORS: PMID:1968061,PMID:3511062 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110061#_f37d9a79_4fa8_4a51_81b3_b7af3e03ead9
constant: false
has only substance units: false
name: _AI373818_1_m
initial concentration: NaN
boundary condition: true
type: Species
initial amount: NaN
is encoded by: hsa:AI373818
is: SBO:0000252

metaM glc D e
is: CHEBI:4167
is: HMDB00122
type: Species
is: SBO:0000247
notes: FORMULA: C6H12O6 CHARGE: 0 INCHI: InChI=1S/C6H12O6/c7-1-2-3(8)4(9)5(10)6(11)12-2/h2-11H,1H2/t2-,3-,4+,5-,6?/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00040
constant: false
initial amount: NaN
initial concentration: 1.0
has only substance units: false
boundary condition: false
name: D-glucose

metaR HISSNAT5tc
kinetic law: MODEL1310110061#
product: MODEL1310110061#
reactant: MODEL1310110061#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: Transport of L-Histidine into the cell coupled with co-transport with Sodium and counter transport with proton by SNAT5 transporter.
type: Reaction

metaR RPI
is: SBO:0000176
reversible: true
notes: GENE_ASSOCIATION: (22934.1) SUBSYSTEM: Pentose phosphate pathway EC Number: 5.3.1.6 Confidence Level: 0 AUTHORS: NOTES:SMP
kinetic law: MODEL1310110061#
product: MODEL1310110061#
is version of: http://identifiers.org/ec-code/5.3.1.6
fast: false
type: Reaction
reactant: MODEL1310110061#
modifier: MODEL1310110061#
is described by: ECO:0000000
name: ribose-5-phosphate isomerase

http://identifiers.org/biomodels.db/MODEL1310110061#_d9caeb39_3422_480e_b0d6_ba7a2d0010b6
boundary condition: true
constant: false
type: Species
is: P35354
is: SBO:0000252
initial concentration: NaN
initial amount: NaN
name: PTGS2
has only substance units: false
is encoded by: hsa:5743

metaM tettet6coa c
is: HMDB06516
constant: false
type: Species
name: tetracosatetraenoyl coenzyme A
notes: FORMULA: C45H70N7O17P3S CHARGE: -4 INCHI: InChI=1/C45H74N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-24-25-36(54)73-29-28-47-35(53)26-27-48-43(57)40(56)45(2,3)31-66-72(63,64)69-71(61,62)65-30-34-39(68-70(58,59)60)38(55)44(67-34)52-33-51-37-41(46)49-32-50-42(37)52/h8-9,11-12,14-15,17-18,32-34,38-40,44,55-56H,4-7,10,13,16,19-31H2,1-3H3,(H,47,53)(H,48,57)(H,61,62)(H,63,64)(H2,46,49,50)(H2,58,59,60)/b9-8-,12-11-,15-14-,18-17-/t34-,38-,39?,40+,44-/m1/s1
is: SBO:0000247
boundary condition: false
is: http://identifiers.org/pubchem.compound/47205481
has only substance units: false
initial concentration: 1.0
initial amount: NaN
is: C16171

metaR r0610
is described by: ECO:0000000
reversible: true
fast: false
type: Reaction
is: SBO:0000176
reactant: MODEL1310110061#
name: CTP:D-Tagatose 6-phosphate 1-phosphotransferase Galactose metabolism EC:2.7.1.11
kinetic law: MODEL1310110061#
product: MODEL1310110061#
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 2.7.1.11 Confidence Level: 0 AUTHORS: PMID:131802,PMID:1810251,PMID:193556,PMID:2987258,PMID:6091737 NOTES:

metaM CE5118 m
notes: FORMULA: C35H52N7O17P3S CHARGE: -4 INCHI: InChI=1/C35H56N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-26(44)63-19-18-37-25(43)16-17-38-33(47)30(46)35(2,3)21-56-62(53,54)59-61(51,52)55-20-24-29(58-60(48,49)50)28(45)34(57-24)42-23-41-27-31(36)39-22-40-32(27)42/h8-9,12-15,22-24,28-30,34,45-46H,4-7,10-11,16-21H2,1-3H3,(H,37,43)(H,38,47)(H,51,52)(H,53,54)(H2,36,39,40)(H2,48,49,50)/p-4/b9-8-,13-12-,15-14+/t24-,28+,29+,30u,34-/m0/s1 EHMN_ABBREVIATION: CE5118
is: CHEBI:57923
has only substance units: false
constant: false
boundary condition: false
initial amount: NaN
type: Species
name: trans-2-cis,cis-4,8-tetradecatrienoyl-CoA
is: SBO:0000247
initial concentration: 1.0

metaM bhb c
boundary condition: false
is: CHEBI:10983
is: SBO:0000247
initial concentration: 1.0
is: HMDB00011
constant: false
initial amount: NaN
name: (R)-3-hydroxybutyrate
has only substance units: false
type: Species
notes: FORMULA: C4H7O3 CHARGE: -1 INCHI: InChI=1S/C4H8O3/c1-3(5)2-4(6)7/h3,5H,2H2,1H3,(H,6,7)/p-1/t3-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00661 EHMN_ABBREVIATION: C01089

http://identifiers.org/biomodels.db/MODEL1310110061#_cfff695a_995a_422a_bf62_f80746decb18
has only substance units: false
constant: false
name: ALDH1A3
initial amount: NaN
type: Species
is encoded by: hsa:220
is: P47895
boundary condition: true
is: SBO:0000252
initial concentration: NaN

metaM lnlncacoa c
notes: FORMULA: C39H60N7O17P3S CHARGE: -4 INCHI: InChI=1S/C39H64N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-30(48)67-23-22-41-29(47)20-21-42-37(51)34(50)39(2,3)25-60-66(57,58)63-65(55,56)59-24-28-33(62-64(52,53)54)32(49)38(61-28)46-27-45-31-35(40)43-26-44-36(31)46/h5-6,8-9,11-12,26-28,32-34,38,49-50H,4,7,10,13-25H2,1-3H3,(H,41,47)(H,42,51)(H,55,56)(H,57,58)(H2,40,43,44)(H2,52,53,54)/b6-5-,9-8-,12-11-/t28-,32-,33-,34+,38-/m1/s1 EHMN_ABBREVIATION: CE4809
is: HMDB06290
initial amount: NaN
is: CHEBI:51985
initial concentration: 1.0
is: SBO:0000247
type: Species
has only substance units: false
name: alpha-Linolenoyl-CoA
boundary condition: false
constant: false

metaR r1585
is described by: ECO:0000000
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reactant: MODEL1310110061#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
product: MODEL1310110061#
fast: false
is: SBO:0000185
type: Reaction
kinetic law: MODEL1310110061#

http://identifiers.org/biomodels.db/MODEL1310110061#_52b10a42_6889_4d98_b1f7_423084d8accd
is: SBO:0000252
constant: false
has only substance units: false
boundary condition: true
is encoded by: hsa:8525
type: Species
name: DGKZ
initial amount: NaN
initial concentration: NaN
is: B7Z6M3

metaM udpg e
is: SBO:0000247
constant: false
has only substance units: false
is: HMDB00286
is: CHEBI:58367
type: Species
name: [(2R,3S,4R,5R)-5-(2,4-dioxo-1,2,3,4-tetrahydropyrimidin-1-yl)-3,4-dihydroxyoxolan-2-yl]methyl {[(3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl phosphonato]oxy}phosphonate
initial concentration: 1.0
notes: FORMULA: C15H22N2O17P2 CHARGE: -2 INCHI: InChI=1S/C15H24N2O17P2/c18-3-5-8(20)10(22)12(24)14(32-5)33-36(28,29)34-35(26,27)30-4-6-9(21)11(23)13(31-6)17-2-1-7(19)16-15(17)25/h1-2,5-6,8-14,18,20-24H,3-4H2,(H,26,27)(H,28,29)(H,16,19,25)/p-2/t5-,6-,8-,9-,10+,11-,12-,13-,14?/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00038 EHMN_ABBREVIATION: C00029
boundary condition: false
initial amount: NaN

metaR r2538
type: Reaction
is: SBO:0000185
kinetic law: MODEL1310110061#
reactant: MODEL1310110061#
is described by: ECO:0000000
name: Utilized transport
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:10049700,PMID:10574970,PMID:11389679,PMID:11557028,PMID:11564694,PMID:12824232,PMID:12930836,PMID:14574404,PMID:16288981,PMID:911815 NOTES:
product: MODEL1310110061#
reversible: true
fast: false

metaR r2323
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
is described by: ECO:0000000
reversible: true
product: MODEL1310110061#
fast: false
kinetic law: MODEL1310110061#
is: SBO:0000185
reactant: MODEL1310110061#

metaM ocdcea r
notes: FORMULA: C18H33O2 CHARGE: -1
is: CHEBI:0
is: HMDB00207
initial concentration: 1.0
constant: false
boundary condition: false
initial amount: NaN
has only substance units: false
is: SBO:0000247
name: octadecenoate (n-C18:1)
type: Species
is: C00712

metaM prostgi2 r
constant: false
is: HMDB01335
has only substance units: false
name: prostaglandin I2(1-)
type: Species
is: CHEBI:57403
initial amount: NaN
boundary condition: false
is: SBO:0000247
notes: FORMULA: C20H31O5 CHARGE: -1 INCHI: InChI=1S/C20H32O5/c1-2-3-4-7-14(21)10-11-16-17-12-15(8-5-6-9-20(23)24)25-19(17)13-18(16)22/h8,10-11,14,16-19,21-22H,2-7,9,12-13H2,1H3,(H,23,24)/p-1/b11-10+,15-8-/t14-,16+,17+,18+,19-/m0/s1 EHMN_ABBREVIATION: C01312
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110061#_5dd37e27_6167_4aee_9559_1fc957bb14ef
initial concentration: NaN
boundary condition: true
initial amount: NaN
is: SBO:0000252
name: SLC5A12
constant: false
has only substance units: false
is encoded by: hsa:159963
is: Q1EHB4
type: Species

http://identifiers.org/biomodels.db/MODEL1310110061#_3d2809c2_ef5f_42b1_b561_220d8f398c6c
constant: false
has only substance units: false
name: DGKZ
type: Species
initial concentration: NaN
initial amount: NaN
boundary condition: true
is: B7Z6M3
is encoded by: hsa:8525
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110061#_e4fba497_6f7d_4ea1_9736_d8a418895ad3
initial amount: NaN
is: P15309
boundary condition: true
is: SBO:0000252
is encoded by: hsa:55
type: Species
constant: false
name: ACPP
has only substance units: false
initial concentration: NaN

metaR EX lac D LPAREN e RPAREN
kinetic law: MODEL1310110061#
reactant: MODEL1310110061#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: D-lactate exchange
type: Reaction

metaR r0541
type: Reaction
product: MODEL1310110061#
notes: GENE_ASSOCIATION: (AV717590.1) or (953.1) or (956.1) or (377841.1) SUBSYSTEM: Tryptophan metabolism EC Number: 1.3.99.7 Confidence Level: 0 AUTHORS: PMID:3081514 NOTES:
kinetic law: MODEL1310110061#
is described by: ECO:0000000
reactant: MODEL1310110061#
reversible: true
modifier: MODEL1310110061#
is version of: http://identifiers.org/ec-code/3.6.1.5
name: Glutaryl-CoA:(acceptor) 2,3-oxidoreductase (decarboxylating) Fatty acid metabolism EC:1.3.99.7
is: SBO:0000176
fast: false

http://identifiers.org/biomodels.db/MODEL1310110061#_bffe2f3b_cea0_4fec_88c1_f65db8e53089
type: Species
constant: false
boundary condition: true
initial amount: NaN
name: _AI924226_1_m
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:AI924226
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110061#_f02c1bbc_60ee_4d81_a78a_2e1fed912997
has only substance units: false
is: A0PJK1
constant: false
is: SBO:0000252
is encoded by: hsa:125206
type: Species
initial amount: NaN
initial concentration: NaN
boundary condition: true
name: SLC5A10

metaR 5ADTSTSTERONESte
reversible: true
type: Reaction
name: sulfonated testosterone transport
is: SBO:0000185
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 1 AUTHORS: NOTES:unknown mechanism - presumed excretion of sulfonated testosterone NJ
kinetic law: MODEL1310110061#
product: MODEL1310110061#
reactant: MODEL1310110061#
fast: false

http://identifiers.org/biomodels.db/MODEL1310110061#_d4e2cf2f_b8f2_490d_848d_937b9b9b3f4c
is: SBO:0000252
type: Species
boundary condition: true
initial amount: NaN
constant: false
is: O43708
name: GSTZ1
is encoded by: hsa:2954
initial concentration: NaN
has only substance units: false

metaR 3HCO3 NAt
reversible: true
product: MODEL1310110061#
reactant: MODEL1310110061#
fast: false
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID: 11875267, PMID: 18077606. NOTES:Na/hco3 co-transporter, expressed at the basolateral side, meant for uptake of hco3, expressed highly in the intestine (NBC1).
is described by: ECO:0000134
is: SBO:0000185
name: 3HCO3_NAt
kinetic law: MODEL1310110061#

http://identifiers.org/biomodels.db/MODEL1310110061#_2980b78d_0372_41fb_a302_55f9f3257a47
name: GGT5
constant: false
type: Species
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:2687
has only substance units: false
is: P36269
boundary condition: true
is: SBO:0000252

metaR r1584
type: Reaction
kinetic law: MODEL1310110061#
is described by: ECO:0000000
fast: false
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is: SBO:0000185
reactant: MODEL1310110061#
product: MODEL1310110061#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1

metaM gdpfuc g
is: CHEBI:57984
boundary condition: false
initial concentration: 1.0
has only substance units: false
is: HMDB01095
initial amount: NaN
constant: false
is: SBO:0000247
type: Species
name: GDP-L-fucose(2-)
notes: FORMULA: C16H23N5O15P2 CHARGE: -2 INCHI: InChI=1S/C16H25N5O15P2/c1-4-7(22)9(24)11(26)15(33-4)35-38(30,31)36-37(28,29)32-2-5-8(23)10(25)14(34-5)21-3-18-6-12(21)19-16(17)20-13(6)27/h3-5,7-11,14-15,22-26H,2H2,1H3,(H,28,29)(H,30,31)(H3,17,19,20,27)/p-2/t4-,5+,7+,8+,9+,10+,11-,14+,15?/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00275 EHMN_ABBREVIATION: C00325

http://identifiers.org/biomodels.db/MODEL1310110061#_f94c5ccd_0256_4900_a6db_4ae6fdaf7865
boundary condition: true
is: P17516
type: Species
name: AKR1C4
constant: false
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:1109
is: SBO:0000252
has only substance units: false

metaR EX HC01609 LPAREN e RPAREN
kinetic law: MODEL1310110061#
reactant: MODEL1310110061#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of UroporphyrinogenI
type: Reaction

metaR LTA4H
product: MODEL1310110061#
modifier: MODEL1310110061#
name: Leukotriene A-4 hydrolase
type: Reaction
kinetic law: MODEL1310110061#
is described by: ECO:0000134
notes: GENE_ASSOCIATION: (4048.1) SUBSYSTEM: Eicosanoid metabolism EC Number: 3.3.2.6 Confidence Level: 4 AUTHORS: PMID:7918238 NOTES:NJ
fast: false
reversible: false
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.3.2.6
reactant: MODEL1310110061#

metaM glc D c
is: HMDB00122
initial amount: NaN
is: SBO:0000247
boundary condition: false
has only substance units: false
type: Species
is: CHEBI:4167
constant: false
initial concentration: 1.0
notes: FORMULA: C6H12O6 CHARGE: 0 INCHI: InChI=1S/C6H12O6/c7-1-2-3(8)4(9)5(10)6(11)12-2/h2-11H,1H2/t2-,3-,4+,5-,6?/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00040
name: D-glucose

metaM CE2424 m
has only substance units: false
is: CHEBI:28387
constant: false
notes: FORMULA: C35H52N7O18P3S CHARGE: -4 INCHI: InChI=1/C35H56N7O18P3S/c1-4-5-6-7-8-9-10-11-12-13-23(43)18-26(45)64-17-16-37-25(44)14-15-38-33(48)30(47)35(2,3)20-57-63(54,55)60-62(52,53)56-19-24-29(59-61(49,50)51)28(46)34(58-24)42-22-41-27-31(36)39-21-40-32(27)42/h8-9,11-12,21-22,24,28-30,34,46-47H,4-7,10,13-20H2,1-3H3,(H,37,44)(H,38,48)(H,52,53)(H,54,55)(H2,36,39,40)(H2,49,50,51)/p-4/b9-8-,12-11-/t24-,28+,29+,30u,34-/m0/s1 EHMN_ABBREVIATION: CE2424
initial concentration: 1.0
boundary condition: false
type: Species
is: SBO:0000247
initial amount: NaN
is: HMDB11123
name: 3-oxo-cis,cis-5,8-tetradecadienoyl-CoA

metaM orot c
boundary condition: false
initial concentration: 1.0
is: CHEBI:30839
has only substance units: false
initial amount: NaN
is: C00295
is: HMDB00226
constant: false
type: Species
notes: FORMULA: C5H3N2O4 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00256 EHMN_ABBREVIATION: C00295
is: SBO:0000247
name: Orotate

metaR r2322
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
is: SBO:0000185
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
reversible: true
kinetic law: MODEL1310110061#
fast: false
product: MODEL1310110061#
reactant: MODEL1310110061#
type: Reaction

metaM 3mob c
boundary condition: false
constant: false
is: HMDB00019
initial concentration: 1.0
has only substance units: false
is: SBO:0000247
notes: FORMULA: C5H7O3 CHARGE: -1 INCHI: InChI=1S/C5H8O3/c1-3(2)4(6)5(7)8/h3H,1-2H3,(H,7,8)/p-1 HEPATONET_1.0_ABBREVIATION: HC00139 EHMN_ABBREVIATION: C00141
is: CHEBI:11851
name: 3-methyl-2-oxobutanoate
initial amount: NaN
type: Species

metaR CYTDK1
kinetic law: MODEL1310110061#
modifier: MODEL1310110061#
is version of: http://identifiers.org/ec-code/2.7.1.48
reversible: false
notes: GENE_ASSOCIATION: (7371.1) or (83549.1) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 2 AUTHORS: NOTES:
fast: false
is described by: ECO:0000254
type: Reaction
is: SBO:0000176
reactant: MODEL1310110061#
product: MODEL1310110061#
name: ATPcytidine 5-phosphotransferase

http://identifiers.org/biomodels.db/MODEL1310110061#_94b18d39_177a_4288_af28_7378f1c778b0
initial amount: NaN
type: Species
has only substance units: false
is encoded by: hsa:AI285872
boundary condition: true
initial concentration: NaN
constant: false
is: SBO:0000252
name: _AI285872_1_c

http://identifiers.org/biomodels.db/MODEL1310110061#_926f5390_60ae_430a_9cee_4cfd6cf278b3
has only substance units: false
boundary condition: true
initial amount: NaN
is: Q548A7
is encoded by: hsa:65010
name: SLC26A6
constant: false
type: Species
initial concentration: NaN
is: SBO:0000252

metaM bhb e
is: HMDB00011
initial amount: NaN
has only substance units: false
name: (R)-3-hydroxybutyrate
notes: FORMULA: C4H7O3 CHARGE: -1 INCHI: InChI=1S/C4H8O3/c1-3(5)2-4(6)7/h3,5H,2H2,1H3,(H,6,7)/p-1/t3-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00661 EHMN_ABBREVIATION: C01089
is: CHEBI:10983
initial concentration: 1.0
constant: false
is: SBO:0000247
type: Species
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110061#_02e79b05_cb3e_43b7_a9d1_ef4c9730be61
name: FDFT1
is encoded by: hsa:2222
is: SBO:0000252
is: P37268
type: Species
initial amount: NaN
boundary condition: true
has only substance units: false
initial concentration: NaN
constant: false

metaR biomass reaction
is: SBO:0000185
name: Generic human biomass reaction
fast: false
reversible: false
reactant: MODEL1310110061#
product: MODEL1310110061#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
kinetic law: MODEL1310110061#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110061#_ba690511_dc52_49e9_9514_5b1d125ac0cc
constant: false
type: Species
initial amount: NaN
boundary condition: true
is: P23786
initial concentration: NaN
has only substance units: false
is: SBO:0000252
is encoded by: hsa:1376
name: CPT2

metaR r0616
type: Reaction
fast: false
name: trans-4-Hydroxy-L-proline:NAD+ 5-oxidoreductase Arginine and proline metabolism EC:1.5.1.2
is: SBO:0000176
product: MODEL1310110061#
reactant: MODEL1310110061#
reversible: true
notes: GENE_ASSOCIATION: (C7orf24.1) SUBSYSTEM: Arginine and Proline Metabolism EC Number: 1.5.1.2 Confidence Level: 0 AUTHORS: PMID:12514185,PMID:3768405,PMID:6250440,PMID:675382 NOTES:
is described by: ECO:0000000
modifier: MODEL1310110061#
kinetic law: MODEL1310110061#

metaR EHGLATm
is version of: http://identifiers.org/ec-code/2.6.1.1
modifier: MODEL1310110061#
notes: GENE_ASSOCIATION: (2806.1) SUBSYSTEM: Arginine and Proline Metabolism EC Number: 2.6.1.1 Confidence Level: 1 AUTHORS: PMID:15849464 NOTES:NCD
is: SBO:0000176
type: Reaction
is described by: ECO:0000212
reactant: MODEL1310110061#
name: L-erythro-4-Hydroxyglutamate:2-oxoglutarate aminotransferase, mitochondrial
kinetic law: MODEL1310110061#
reversible: false
fast: false
product: MODEL1310110061#

metaM 5oxpro e
type: Species
boundary condition: false
constant: false
is: HMDB00267
initial concentration: 1.0
notes: FORMULA: C5H6NO3 CHARGE: -1 INCHI: InChI=1S/C5H7NO3/c7-4-2-1-3(6-4)5(8)9/h3H,1-2H2,(H,6,7)(H,8,9)/p-1
initial amount: NaN
name: 5-oxoprolinate
is: CHEBI:57606
is: SBO:0000247
has only substance units: false

metaR RE1531M
is described by: ECO:0000000
fast: false
type: Reaction
modifier: MODEL1310110061#
notes: GENE_ASSOCIATION: (10449.1) or (3032.1) or (3030.1) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.16 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:7923814,PMID:9568246,PMID:9920399 NOTES:
is version of: http://identifiers.org/ec-code/4.2.1.17
kinetic law: MODEL1310110061#
is version of: http://identifiers.org/ec-code/2.3.1.16
reversible: true
name: RE1531
product: MODEL1310110061#
reactant: MODEL1310110061#
is: SBO:0000176

metaR r1587
reactant: MODEL1310110061#
product: MODEL1310110061#
is: SBO:0000185
type: Reaction
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is described by: ECO:0000000
kinetic law: MODEL1310110061#
fast: false

metaM udpg c
initial amount: NaN
has only substance units: false
notes: FORMULA: C15H22N2O17P2 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00038 EHMN_ABBREVIATION: C00029
is: SBO:0000247
is: C00029
constant: false
initial concentration: 1.0
is: CHEBI:58367
is: HMDB00286
type: Species
name: UDPglucose
boundary condition: false

metaR TSTSTERONEt
reversible: true
product: MODEL1310110061#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: 2.8.2.2 Confidence Level: 2 AUTHORS: PMID:1588921,PMID:16399349 NOTES:
reactant: MODEL1310110061#
fast: false
is: SBO:0000185
is described by: ECO:0000269
name: Testosterone transport
kinetic law: MODEL1310110061#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110061#_c599e9fa_e020_4031_9ff2_164148aff0d7
initial amount: NaN
boundary condition: true
has only substance units: false
initial concentration: NaN
name: _AA526438_1_m
type: Species
is encoded by: hsa:AA526438
constant: false
is: SBO:0000252

metaR DM melanin c
kinetic law: MODEL1310110061#
reactant: MODEL1310110061#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 0 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: false
name: DM melanin(c)
type: Reaction

metaR FACOAL181i
reactant: MODEL1310110061#
kinetic law: MODEL1310110061#
reversible: false
fast: false
modifier: MODEL1310110061#
is version of: http://identifiers.org/ec-code/6.2.1.3
name: C181 fatty acid activation
is described by: ECO:0000269
is: SBO:0000176
product: MODEL1310110061#
type: Reaction
notes: GENE_ASSOCIATION: (2180.1) or (2181.2) or (2181.1) SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 4 AUTHORS: NOTES:TV catalyzed by acyl-CoA synthetases

metaR HACD1m
reactant: MODEL1310110061#
product: MODEL1310110061#
type: Reaction
is version of: http://identifiers.org/ec-code/2.3.1.16
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.1.1.35
kinetic law: MODEL1310110061#
name: 3-hydroxyacyl-CoA dehydrogenase (acetoacetyl-CoA) (mitochondria)
is described by: ECO:0000134
modifier: MODEL1310110061#
is version of: http://identifiers.org/ec-code/4.2.1.17
fast: false
reversible: true
notes: GENE_ASSOCIATION: (3028.1) or (3033.1) or (3030.1) and (3032.1) SUBSYSTEM: Tryptophan metabolism EC Number: 1.1.1.35 Confidence Level: 1 AUTHORS: PMID:17143551,PMID:17143552 NOTES:Same as EC 1.1.1.157 SAB mito. some physiological

metaR r2325
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
reversible: true
is: SBO:0000185
fast: false
product: MODEL1310110061#
type: Reaction
reactant: MODEL1310110061#
kinetic law: MODEL1310110061#

metaR RE3003M
fast: false
modifier: MODEL1310110061#
is version of: http://identifiers.org/ec-code/1.1.1.35
reactant: MODEL1310110061#
is version of: http://identifiers.org/ec-code/5.3.3.8
is: SBO:0000176
reversible: true
kinetic law: MODEL1310110061#
type: Reaction
notes: GENE_ASSOCIATION: (1632.1) or (10455.1) or (1962.1) SUBSYSTEM: Fatty acid oxidation EC Number: 5.3.3.8 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:7775433 NOTES:
is described by: ECO:0000000
product: MODEL1310110061#
name: RE3003

http://identifiers.org/biomodels.db/MODEL1310110061#_244bbbee_ef3a_471c_9c77_37b6a595ae3f
type: Species
is: SBO:0000252
constant: false
has only substance units: false
initial concentration: NaN
name: _AA081045_1_m
boundary condition: true
is encoded by: hsa:AA081045
initial amount: NaN

metaM mlthf m
is: HMDB01533
name: 5,10-Methylenetetrahydrofolate
has only substance units: false
initial concentration: 1.0
boundary condition: false
is: C00143
is: CHEBI:15636
type: Species
initial amount: NaN
notes: FORMULA: C20H21N7O6 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00140 EHMN_ABBREVIATION: C00143
constant: false
is: SBO:0000247

metaM bilirub r
initial amount: NaN
notes: FORMULA: C33H34N4O6 CHARGE: -2 INCHI: InChI=1S/C33H36N4O6/c1-7-20-19(6)32(42)37-27(20)14-25-18(5)23(10-12-31(40)41)29(35-25)15-28-22(9-11-30(38)39)17(4)24(34-28)13-26-16(3)21(8-2)33(43)36-26/h7-8,13-14,34-35H,1-2,9-12,15H2,3-6H3,(H,36,43)(H,37,42)(H,38,39)(H,40,41)/p-2/b26-13-,27-14- HEPATONET_1.0_ABBREVIATION: HC00385 EHMN_ABBREVIATION: C00486
is: HMDB00054
is: SBO:0000247
is: CHEBI:57977
type: Species
has only substance units: false
boundary condition: false
name: bilirubin(2-)
constant: false
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110061#_fddd5245_6a46_42ed_b481_5234507c820a
has only substance units: false
boundary condition: true
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:2629
is: SBO:0000252
constant: false
type: Species
name: GBA
is: B7Z6S1

http://identifiers.org/biomodels.db/MODEL1310110061#_fd2a98bf_0937_4449_b81e_f177322a4cce
has only substance units: false
boundary condition: true
is encoded by: hsa:30
initial amount: NaN
type: Species
initial concentration: NaN
name: ACAA1
constant: false
is: SBO:0000252
is: Q96CA6

http://identifiers.org/biomodels.db/MODEL1310110061#_756a9369_1943_4cad_848a_2996d4dc2223
constant: false
name: DGKE
is: A1L4Q0
initial amount: NaN
boundary condition: true
is encoded by: hsa:8526
has only substance units: false
initial concentration: NaN
is: SBO:0000252
type: Species

metaR EX leuktrF4 LPAREN e RPAREN
kinetic law: MODEL1310110061#
reactant: MODEL1310110061#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: leukotriene F4 exchange
type: Reaction

metaR r1586
is described by: ECO:0000000
kinetic law: MODEL1310110061#
is: SBO:0000185
reactant: MODEL1310110061#
product: MODEL1310110061#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
fast: false
type: Reaction
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:

metaR r2537
kinetic law: MODEL1310110061#
type: Reaction
reactant: MODEL1310110061#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:10049700,PMID:10574970,PMID:11389679,PMID:11557028,PMID:11564694,PMID:12824232,PMID:12930836,PMID:14574404,PMID:16288981,PMID:911815 NOTES:
is described by: ECO:0000000
product: MODEL1310110061#
reversible: true
is: SBO:0000185
name: Utilized transport

metaR r0340
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.3.1.38
type: Reaction
kinetic law: MODEL1310110061#
fast: false
notes: GENE_ASSOCIATION: (AA526438.1) or (H17063.1) or (51102.1) or (55825.1) SUBSYSTEM: Unassigned EC Number: 2.7.1.31 Confidence Level: 0 AUTHORS: PMID:16753811,PMID:216417,PMID:2537226,PMID:6252205 NOTES:
product: MODEL1310110061#
modifier: MODEL1310110061#
reversible: false
name: ATP:(R)-glycerate 3-phosphotransferase Glycine, serine and threonine metabolism EC:2.7.1.31
is described by: ECO:0000000
reactant: MODEL1310110061#

metaR C14STRr
reversible: false
type: Reaction
is version of: http://identifiers.org/ec-code/1.3.1.70
fast: false
is: SBO:0000176
product: MODEL1310110061#
is described by: ECO:0000134
modifier: MODEL1310110061#
kinetic law: MODEL1310110061#
notes: GENE_ASSOCIATION: (7108.1) SUBSYSTEM: Cholesterol metabolism EC Number: 1.3.1.70 Confidence Level: 4 AUTHORS: PMID:16784888 NOTES:NCD ER version NJ
reactant: MODEL1310110061#
name: C-14 sterol reductase

metaR 5MTHFt2le
fast: false
is described by: ECO:0000134
product: MODEL1310110061#
reactant: MODEL1310110061#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
kinetic law: MODEL1310110061#
name: 5-methyltetrahydrofolate transport via anion exchange
reversible: true
type: Reaction
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110061#_9f6308bc_6560_486e_a648_ebd6c2aff706
is: SBO:0000252
type: Species
is: P30613
initial concentration: NaN
has only substance units: false
boundary condition: true
is encoded by: hsa:5313
initial amount: NaN
constant: false
name: PKLR

http://identifiers.org/biomodels.db/MODEL1310110061#_501adcd2_378c_4011_a574_47d7450d3629
has only substance units: false
name: SLC25A4
is: P12235
initial amount: NaN
type: Species
is: SBO:0000252
boundary condition: true
initial concentration: NaN
constant: false
is encoded by: hsa:291

http://identifiers.org/biomodels.db/MODEL1310110061#_5ece12d7_d374_49a1_ba46_72a82b28b2e5
initial concentration: NaN
is encoded by: hsa:686
initial amount: NaN
type: Species
name: BTD
has only substance units: false
is: P43251
constant: false
is: SBO:0000252
boundary condition: true

metaR r2324
is described by: ECO:0000000
is: SBO:0000185
reversible: true
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
product: MODEL1310110061#
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
kinetic law: MODEL1310110061#
type: Reaction
reactant: MODEL1310110061#

metaR r0033
is described by: ECO:0000000
name: ATP:dephospho-CoA 3-phosphotransferase Pantothenate and CoA biosynthesis EC:2.7.1.24
reactant: MODEL1310110061#
product: MODEL1310110061#
fast: false
notes: GENE_ASSOCIATION: (AV717590.1) or (953.1) or (956.1) or (377841.1) SUBSYSTEM: CoA synthesis EC Number: 2.7.1.24 Confidence Level: 0 AUTHORS: PMID:11923312,PMID:11994049,PMID:13163064,PMID:15893380 NOTES:
is version of: http://identifiers.org/ec-code/3.6.1.5
modifier: MODEL1310110061#
reversible: false
kinetic law: MODEL1310110061#
is: SBO:0000176
type: Reaction

metaR EX prostgf2 LPAREN e RPAREN
kinetic law: MODEL1310110061#
reactant: MODEL1310110061#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Prostaglandin F2alpha exchange
type: Reaction

metaM thyox L c
constant: false
is: SBO:0000247
initial amount: NaN
type: Species
notes: FORMULA: C15H11I4NO4 CHARGE: 0 INCHI: InChI=1S/C15H11I4NO4/c16-8-4-7(5-9(17)13(8)21)24-14-10(18)1-6(2-11(14)19)3-12(20)15(22)23/h1-2,4-5,12,21H,3,20H2,(H,22,23)/t12-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00849
boundary condition: false
initial concentration: 1.0
name: L-thyroxine
is: CHEBI:18332
has only substance units: false
is: HMDB00248

metaM 5oxpro c
initial concentration: 1.0
name: 5-oxoprolinate
boundary condition: false
has only substance units: false
type: Species
constant: false
is: SBO:0000247
is: HMDB00267
notes: FORMULA: C5H6NO3 CHARGE: -1 INCHI: InChI=1S/C5H7NO3/c7-4-2-1-3(6-4)5(8)9/h3H,1-2H2,(H,6,7)(H,8,9)/p-1 HEPATONET_1.0_ABBREVIATION: HC00856 EHMN_ABBREVIATION: C01879
initial amount: NaN
is: CHEBI:57606

metaM lnlccrn m
initial amount: NaN
notes: FORMULA: C25H45NO4 CHARGE: 0 INCHI: InChI=1/C25H45NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-25(29)30-23(21-24(27)28)22-26(2,3)4/h9-10,12-13,23H,5-8,11,14-22H2,1-4H3/b10-9-,13-12-/t23-/m1/s1
name: Linoleyl carnitine
is: HMDB06469
has only substance units: false
type: Species
initial concentration: 1.0
is: SBO:0000247
boundary condition: false
constant: false

metaR RPE
notes: GENE_ASSOCIATION: (6120.1) or (6120.2) SUBSYSTEM: Pentose phosphate pathway EC Number: 5.1.3.1 Confidence Level: 0 AUTHORS: NOTES:SMP
reactant: MODEL1310110061#
kinetic law: MODEL1310110061#
is described by: ECO:0000000
is: SBO:0000176
fast: false
modifier: MODEL1310110061#
reversible: true
product: MODEL1310110061#
is version of: http://identifiers.org/ec-code/5.1.3.1
type: Reaction
name: ribulose 5-phosphate 3-epimerase

metaM dutp c
initial concentration: 1.0
is: HMDB01191
type: Species
is: SBO:0000247
constant: false
boundary condition: false
notes: FORMULA: C9H11N2O14P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00369 EHMN_ABBREVIATION: C00460
is: CHEBI:17625
is: C00460
name: dUTP
has only substance units: false
initial amount: NaN

metaR PSP L
is: SBO:0000176
type: Reaction
is version of: http://identifiers.org/ec-code/3.1.3.3
kinetic law: MODEL1310110061#
reactant: MODEL1310110061#
name: phosphoserine phosphatase (L-serine)
modifier: MODEL1310110061#
reversible: false
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (8781.1) or (5723.1) SUBSYSTEM: Glycine, serine, alanine and threonine metabolism EC Number: 3.1.3.3 Confidence Level: 4 AUTHORS: PMID:9188776,PMID:9573387 NOTES:
fast: false
product: MODEL1310110061#

metaM orot e
initial amount: NaN
is: HMDB00226
notes: FORMULA: C5H3N2O4 CHARGE: -1 INCHI: InChI=1S/C5H4N2O4/c8-3-1-2(4(9)10)6-5(11)7-3/h1H,(H,9,10)(H2,6,7,8,11)/p-1 HEPATONET_1.0_ABBREVIATION: HC00256 EHMN_ABBREVIATION: C00295
is: CHEBI:30839
boundary condition: false
name: orotate
initial concentration: 1.0
constant: false
has only substance units: false
type: Species
is: SBO:0000247

metaM 3mob e
constant: false
is: HMDB00019
boundary condition: false
notes: FORMULA: C5H7O3 CHARGE: -1 INCHI: InChI=1S/C5H8O3/c1-3(2)4(6)5(7)8/h3H,1-2H3,(H,7,8)/p-1
initial concentration: 1.0
is: SBO:0000247
initial amount: NaN
is: CHEBI:11851
has only substance units: false
type: Species
name: 3-methyl-2-oxobutanoate

metaR r0614
name: N-[(R)-4-Phosphopantothenoyl]-L-cysteine carboxy-lyase Pantothenate and CoA biosynthesis EC:4.1.1.36
type: Reaction
reactant: MODEL1310110061#
is: SBO:0000176
product: MODEL1310110061#
fast: false
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: CoA synthesis EC Number: 4.1.1.36 Confidence Level: 0 AUTHORS: PMID:11923312,PMID:13630913,PMID:15893380,PMID:4459135,PMID:6061681 NOTES:
kinetic law: MODEL1310110061#
is described by: ECO:0000000

metaM prostgd2 e
is: HMDB01403
name: prostaglandin D2(1-)
is: SBO:0000247
boundary condition: false
initial concentration: 1.0
has only substance units: false
constant: false
is: CHEBI:57406
notes: FORMULA: C20H31O5 CHARGE: -1 INCHI: InChI=1S/C20H32O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h4,7,12-13,15-18,21-22H,2-3,5-6,8-11,14H2,1H3,(H,24,25)/p-1/b7-4-,13-12+/t15-,16+,17+,18-/m0/s1 EHMN_ABBREVIATION: C00696
initial amount: NaN
type: Species

metaR r2111
kinetic law: MODEL1310110061#
fast: false
is described by: ECO:0000000
type: Reaction
reversible: true
is: SBO:0000185
reactant: MODEL1310110061#
modifier: MODEL1310110061#
product: MODEL1310110061#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:

metaR CYSO
reactant: MODEL1310110061#
type: Reaction
notes: GENE_ASSOCIATION: (1036.1) SUBSYSTEM: Taurine and hypotaurine metabolism EC Number: 1.13.11.20 Confidence Level: 4 AUTHORS: PMID:14514920 NOTES:IT
is: SBO:0000176
kinetic law: MODEL1310110061#
is described by: ECO:0000269
modifier: MODEL1310110061#
reversible: false
product: MODEL1310110061#
is version of: http://identifiers.org/ec-code/1.13.11.20
fast: false
name: cysteine oxidase

metaR FACOAL2252
reversible: true
is: SBO:0000176
product: MODEL1310110061#
type: Reaction
notes: GENE_ASSOCIATION: (2180.1) SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 4 AUTHORS: PMID:15292367 NOTES:NJ
fast: false
is version of: http://identifiers.org/ec-code/6.2.1.3
is described by: ECO:0000269
kinetic law: MODEL1310110061#
reactant: MODEL1310110061#
name: fatty-acid--CoA ligase
modifier: MODEL1310110061#

metaM 2obut m
is: HMDB00005
type: Species
notes: FORMULA: C4H5O3 CHARGE: -1 INCHI: InChI=1S/C4H6O3/c1-2-3(5)4(6)7/h2H2,1H3,(H,6,7)/p-1 HEPATONET_1.0_ABBREVIATION: HC00108 EHMN_ABBREVIATION: C00109
initial amount: NaN
has only substance units: false
is: CHEBI:16763
initial concentration: 1.0
name: 2-oxobutanoate
constant: false
boundary condition: false
is: SBO:0000247

metaM 3odcoa m
has only substance units: false
constant: false
name: 3-Oxodecanoyl-CoA
is: CHEBI:28528
is: SBO:0000247
initial amount: NaN
boundary condition: false
notes: FORMULA: C31H48N7O18P3S CHARGE: -4 INCHI: InChI=1S/C31H52N7O18P3S/c1-4-5-6-7-8-9-19(39)14-22(41)60-13-12-33-21(40)10-11-34-29(44)26(43)31(2,3)16-53-59(50,51)56-58(48,49)52-15-20-25(55-57(45,46)47)24(42)30(54-20)38-18-37-23-27(32)35-17-36-28(23)38/h17-18,20,24-26,30,42-43H,4-16H2,1-3H3,(H,33,40)(H,34,44)(H,48,49)(H,50,51)(H2,32,35,36)(H2,45,46,47)/t20-,24-,25-,26+,30-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01404 EHMN_ABBREVIATION: C05265
type: Species
initial concentration: 1.0
is: HMDB03939

metaR r2364
name: Organic anion transporter 5 Utilized transport
type: Reaction
kinetic law: MODEL1310110061#
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
reactant: MODEL1310110061#
is described by: ECO:0000000
product: MODEL1310110061#
is: SBO:0000185
fast: false

metaR CYTK6
reactant: MODEL1310110061#
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
is version of: http://identifiers.org/ec-code/2.7.4.14
reversible: true
name: cytidylate kinase (CMP,CTP)
fast: false
modifier: MODEL1310110061#
is: SBO:0000176
type: Reaction
kinetic law: MODEL1310110061#
product: MODEL1310110061#

metaR r2509
reversible: true
is described by: ECO:0000000
name: Utilized transport
fast: false
kinetic law: MODEL1310110061#
type: Reaction
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:17466261 NOTES:
product: MODEL1310110061#
reactant: MODEL1310110061#

metaR LGNCt
kinetic law: MODEL1310110061#
reactant: MODEL1310110061#
is described by: ECO:0000000
fast: false
product: MODEL1310110061#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11788354,PMID:12864740 NOTES:NJ
type: Reaction
is: SBO:0000185
name: fatty acid transport via diffusion
reversible: true

metaM 5adtststerone e
initial concentration: 1.0
is: SBO:0000247
is: HMDB02961
is: CHEBI:16330
constant: false
boundary condition: false
name: 17beta-hydroxy-5alpha-androstan-3-one
notes: FORMULA: C19H30O2 CHARGE: 0 INCHI: InChI=1S/C19H30O2/c1-18-9-7-13(20)11-12(18)3-4-14-15-5-6-17(21)19(15,2)10-8-16(14)18/h12,14-17,21H,3-11H2,1-2H3/t12-,14-,15-,16-,17-,18-,19-/m0/s1 EHMN_ABBREVIATION: C03917
type: Species
initial amount: NaN
has only substance units: false

metaR MI145PK
modifier: MODEL1310110061#
product: MODEL1310110061#
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/2.7.1.127
name: inositol-1,4,5-trisphosphate 3-kinase
reversible: false
notes: GENE_ASSOCIATION: (3706.1) or (80271.1) or (3707.1) SUBSYSTEM: Inositol phosphate metabolism EC Number: 2.7.1.127 Confidence Level: 4 AUTHORS: PMID:11085927,PMID:1654894,PMID:2906139 NOTES:NCD
fast: false
reactant: MODEL1310110061#
is: SBO:0000176
type: Reaction
kinetic law: MODEL1310110061#

metaM 3mob m
is: HMDB00019
boundary condition: false
notes: FORMULA: C5H7O3 CHARGE: -1 INCHI: InChI=1S/C5H8O3/c1-3(2)4(6)5(7)8/h3H,1-2H3,(H,7,8)/p-1 HEPATONET_1.0_ABBREVIATION: HC00139 EHMN_ABBREVIATION: C00141
initial amount: NaN
has only substance units: false
initial concentration: 1.0
constant: false
is: CHEBI:11851
type: Species
name: 3-methyl-2-oxobutanoate
is: SBO:0000247

metaR NAIt
is described by: ECO:0000269
modifier: MODEL1310110061#
reactant: MODEL1310110061#
notes: GENE_ASSOCIATION: (6528.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10893432,PMID:11034615,PMID:12679487,PMID:12748858,PMID:15546855,PMID:8559252,PMID:8806637,PMID:9341168 NOTES:NCD
product: MODEL1310110061#
fast: false
is: SBO:0000185
type: Reaction
kinetic law: MODEL1310110061#
name: Na+ / iodide cotransport
reversible: true

metaM glu5sa m
is: SBO:0000247
type: Species
is: HMDB02104
initial concentration: 1.0
name: L-Glutamate 5-semialdehyde
boundary condition: false
has only substance units: false
initial amount: NaN
is: C01165
is: CHEBI:17232
constant: false
notes: FORMULA: C5H9NO3 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00694 EHMN_ABBREVIATION: C01165

http://identifiers.org/biomodels.db/MODEL1310110061#_6b8a73bf_d591_4a27_9340_99944b9c059f
name: IDH2
is encoded by: hsa:3418
is: SBO:0000252
boundary condition: true
constant: false
type: Species
has only substance units: false
initial amount: NaN
initial concentration: NaN
is: P48735

http://identifiers.org/biomodels.db/MODEL1310110061#_8c12c9bf_2f8f_43bc_a779_8b3f075503c3
boundary condition: true
is: SBO:0000252
constant: false
is encoded by: hsa:7296
name: TXNRD1
initial amount: NaN
has only substance units: false
type: Species
initial concentration: NaN

metaM pmtcoa m
name: Palmitoyl-CoA (n-C16:0CoA)
is: SBO:0000247
has only substance units: false
is: HMDB01338
constant: false
notes: FORMULA: C37H62N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00150 EHMN_ABBREVIATION: C00154
initial amount: NaN
initial concentration: 1.0
is: C00154
boundary condition: false
type: Species
is: CHEBI:57379

http://identifiers.org/biomodels.db/MODEL1310110061#_03ccf42c_3fd3_4da6_82bf_71bda6254f12
constant: false
has only substance units: false
is encoded by: hsa:6888
is: SBO:0000252
is: P37837
initial concentration: NaN
name: TALDO1
boundary condition: true
type: Species
initial amount: NaN

metaM tetpent6coa x
type: Species
initial concentration: 1.0
boundary condition: false
name: tetracosapentaenoyl coenzyme A, n-6
has only substance units: false
is: C16172
is: SBO:0000247
notes: FORMULA: C45H68N7O17P3S CHARGE: -4 INCHI: InChI=1/C45H72N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-24-25-36(54)73-29-28-47-35(53)26-27-48-43(57)40(56)45(2,3)31-66-72(63,64)69-71(61,62)65-30-34-39(68-70(58,59)60)38(55)44(67-34)52-33-51-37-41(46)49-32-50-42(37)52/h8-9,11-12,14-15,17-18,20-21,32-34,38-40,44,55-56H,4-7,10,13,16,19,22-31H2,1-3H3,(H,47,53)(H,48,57)(H,61,62)(H,63,64)(H2,46,49,50)(H2,58,59,60)/b9-8-,12-11-,15-14-,18-17-,21-20-/t34-,38-,39-,40?,44-/m1/s1
constant: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110061#_985d39f6_6538_4ff3_a113_3cd8bd7722bc
initial amount: NaN
is: Q92959
initial concentration: NaN
name: SLCO2A1
type: Species
boundary condition: true
is: SBO:0000252
has only substance units: false
is encoded by: hsa:6578
constant: false

metaR r0796
is described by: ECO:0000000
reactant: MODEL1310110061#
is: SBO:0000176
fast: false
kinetic law: MODEL1310110061#
modifier: MODEL1310110061#
name: Ribitol:NAD+ 2-oxidoreductase Pentose and glucuronate interconversions EC:1.1.1.56
product: MODEL1310110061#
is version of: http://identifiers.org/ec-code/1.2.1.5
type: Reaction
reversible: true
notes: GENE_ASSOCIATION: (220.1) or (218.1) or (221.1) or (222.1) or (U37519.1) SUBSYSTEM: Pentose phosphate pathway EC Number: Confidence Level: 0 AUTHORS: PMID:15234337 NOTES:

metaM 4nph e
is: HMDB01232
initial amount: NaN
notes: FORMULA: C6H5NO3 CHARGE: 0 INCHI: InChI=1S/C6H5NO3/c8-6-3-1-5(2-4-6)7(9)10/h1-4,8H/p-1 HEPATONET_1.0_ABBREVIATION: HC00570 EHMN_ABBREVIATION: C00870
has only substance units: false
is: CHEBI:57917
initial concentration: 1.0
boundary condition: false
name: 4-nitrophenolate
constant: false
type: Species
is: SBO:0000247

metaR UGT1A10r
reversible: true
name: UDP-glucuronosyltransferase 1-10 precursor, microsomal
product: MODEL1310110061#
modifier: MODEL1310110061#
is version of: http://identifiers.org/ec-code/2.4.1.17
notes: GENE_ASSOCIATION: (54576.1) SUBSYSTEM: Steroid metabolism EC Number: 2.4.1.17 Confidence Level: 1 AUTHORS: PMID:7945246 NOTES:bil is taken up by cell - made reversible (actual measurements of deltaG/reversibility not described in literature currently) NJ. rate of estradiol (alpha and beta) glucuronidation by human bilirubin UGT quantified
is described by: ECO:0000134
kinetic law: MODEL1310110061#
is: SBO:0000176
reactant: MODEL1310110061#
fast: false
type: Reaction

metaR RE3520E
product: MODEL1310110061#
notes: GENE_ASSOCIATION: (2880.1) or (257202.1) or (2882.1) or (2878.1) SUBSYSTEM: Arachidonic acid metabolism EC Number: 1.11.1.9 Confidence Level: 0 AUTHORS: PMID:10224163,PMID:2377602,PMID:3942774,PMID:9837935 NOTES:
name: RE3520
reactant: MODEL1310110061#
fast: false
reversible: true
kinetic law: MODEL1310110061#
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/1.11.1.9
modifier: MODEL1310110061#
is: SBO:0000176
type: Reaction

metaR r2110
product: MODEL1310110061#
kinetic law: MODEL1310110061#
is: SBO:0000185
is described by: ECO:0000000
modifier: MODEL1310110061#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
type: Reaction
reversible: true
fast: false
reactant: MODEL1310110061#

http://identifiers.org/biomodels.db/MODEL1310110061#_f1271a96_9efe_44ea_8d8e_bfe38fbca79f
boundary condition: true
has only substance units: false
initial concentration: NaN
initial amount: NaN
type: Species
is encoded by: hsa:126410
constant: false
name: CYP4F22
is: SBO:0000252
is: Q6NT55

http://identifiers.org/biomodels.db/MODEL1310110061#_10c9616b_fb83_4ed0_beb1_e54c45e27cfe
name: PLCD1
type: Species
boundary condition: true
is: P51178
is: SBO:0000252
is encoded by: hsa:5333
constant: false
initial amount: NaN
initial concentration: NaN
has only substance units: false

metaR KYNATESYN
name: 4-(2-Aminophenyl)-2,4-dioxobutanoate dehydratase
fast: false
reversible: false
kinetic law: MODEL1310110061#
reactant: MODEL1310110061#
is: SBO:0000176
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Tryptophan metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:15016471,PMID:16008534 NOTES:SAB name is a guess
is described by: ECO:0000000
product: MODEL1310110061#

metaR FACOAL2251
notes: GENE_ASSOCIATION: (2180.1) SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 4 AUTHORS: PMID:15292367 NOTES:NJ
is described by: ECO:0000000
fast: false
reversible: true
is: SBO:0000176
name: fatty-acid--CoA ligase
product: MODEL1310110061#
type: Reaction
modifier: MODEL1310110061#
is version of: http://identifiers.org/ec-code/6.2.1.3
kinetic law: MODEL1310110061#
reactant: MODEL1310110061#

metaR CYTK7
fast: false
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
kinetic law: MODEL1310110061#
product: MODEL1310110061#
reactant: MODEL1310110061#
is version of: http://identifiers.org/ec-code/2.7.4.14
modifier: MODEL1310110061#
is: SBO:0000176
type: Reaction
name: cytidylate kinase (CMP,UTP)
reversible: true
is described by: ECO:0000269

metaR r2365
product: MODEL1310110061#
type: Reaction
is: SBO:0000185
kinetic law: MODEL1310110061#
fast: false
reactant: MODEL1310110061#
reversible: true
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
name: Organic anion transporter 5 Utilized transport

http://identifiers.org/biomodels.db/MODEL1310110061#_53d4c3fc_ea33_4f44_bf0e_2f972f3f1b43
is: SBO:0000252
boundary condition: true
initial amount: NaN
constant: false
type: Species
name: _AI539321_1_c
initial concentration: NaN
has only substance units: false
is encoded by: hsa:AI539321

metaM nadph r
initial concentration: 1.0
is: C00005
name: Nicotinamide adenine dinucleotide phosphate - reduced
notes: FORMULA: C21H26N7O17P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00015 EHMN_ABBREVIATION: C00005
initial amount: NaN
is: SBO:0000247
boundary condition: false
has only substance units: false
constant: false
is: HMDB00221
type: Species
is: CHEBI:57783

http://identifiers.org/biomodels.db/MODEL1310110061#_2ae41c2d_68bd_4c9c_b3e9_7d8b85fbc37c
has only substance units: false
is: SBO:0000252
constant: false
type: Species
boundary condition: true
name: CHAT
is encoded by: hsa:1103
is: Q6LEN5
initial amount: NaN
initial concentration: NaN

metaR r2508
name: Utilized transport
type: Reaction
fast: false
product: MODEL1310110061#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:17466261 NOTES:
reversible: true
is: SBO:0000185
reactant: MODEL1310110061#
kinetic law: MODEL1310110061#
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110061#_8094a85b_21a4_4007_be37_a03ff584c126
is encoded by: hsa:84076
constant: false
is: SBO:0000252
name: TKTL2
boundary condition: true
initial amount: NaN
is: Q9H0I9
has only substance units: false
type: Species
initial concentration: NaN

metaR KCC2t
notes: GENE_ASSOCIATION: (6560.1) or (10723.1) or (9990.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10187864,PMID:10347194,PMID:10600773,PMID:121106695,PMID:12657561,PMID:8663127 NOTES:NCD
is described by: ECO:0000269
modifier: MODEL1310110061#
type: Reaction
product: MODEL1310110061#
reactant: MODEL1310110061#
fast: false
is: SBO:0000185
reversible: true
name: K+-Cl- cotransporter (NH4+)
kinetic law: MODEL1310110061#

metaM xoltriol c
type: Species
is: CHEBI:16496
constant: false
boundary condition: false
initial concentration: 1.0
notes: FORMULA: C27H48O3 CHARGE: 0 INCHI: InChI=1S/C27H48O3/c1-16(2)7-6-8-17(3)20-9-10-21-25-22(15-24(30)27(20,21)5)26(4)12-11-19(28)13-18(26)14-23(25)29/h16-25,28-30H,6-15H2,1-5H3/t17-,18+,19-,20-,21+,22+,23-,24+,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01463 EHMN_ABBREVIATION: C05454
name: 5beta-cholestane-3alpha,7alpha,12alpha-triol
is: HMDB01457
is: SBO:0000247
initial amount: NaN
has only substance units: false

metaR 4HGLSDm
product: MODEL1310110061#
notes: GENE_ASSOCIATION: (8659.1) or (8659.2) SUBSYSTEM: Arginine and Proline Metabolism EC Number: 1.5.1.12 Confidence Level: 1 AUTHORS: PMID:15849464 NOTES:NCD
kinetic law: MODEL1310110061#
reversible: true
modifier: MODEL1310110061#
is: SBO:0000176
reactant: MODEL1310110061#
fast: false
type: Reaction
name: L-4-hydroxyglutamate semialdehyde dehydrogenase, mitochondrial
is version of: http://identifiers.org/ec-code/1.5.1.12
is described by: ECO:0000212

http://identifiers.org/biomodels.db/MODEL1310110061#_81df9219_e6c5_44b7_8122_365bc127bac4
name: SLC2A6
constant: false
type: Species
has only substance units: false
boundary condition: true
is: Q9UGQ3
initial concentration: NaN
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:11182

http://identifiers.org/biomodels.db/MODEL1310110061#_a5a561d2_5908_46dd_a9cf_ee70c46151bb
name: MYO5B
is: SBO:0000252
initial concentration: NaN
is: Q9H6Y6
has only substance units: false
constant: false
type: Species
initial amount: NaN
is encoded by: hsa:4645
boundary condition: true

metaM sphs1p c
is: HMDB00277
is: CHEBI:60119
initial concentration: 1.0
boundary condition: false
initial amount: NaN
type: Species
has only substance units: false
notes: FORMULA: C18H37NO5P CHARGE: -1 INCHI: InChI=1S/C18H38NO5P/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-18(20)17(19)16-24-25(21,22)23/h14-15,17-18,20H,2-13,16,19H2,1H3,(H2,21,22,23)/p-1/b15-14+/t17-,18+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01702 EHMN_ABBREVIATION: C06124
name: sphingosine 1-phosphate(1-)
constant: false
is: SBO:0000247

metaR DOPAt4 2 r
notes: GENE_ASSOCIATION: (6530.1) or (6531.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12719981 NOTES:SAB
reactant: MODEL1310110061#
fast: false
type: Reaction
reversible: true
name: Dopamine reversible transport in via sodium symport (1:2)
modifier: MODEL1310110061#
is: SBO:0000185
is described by: ECO:0000269
product: MODEL1310110061#
kinetic law: MODEL1310110061#

metaR r0797
kinetic law: MODEL1310110061#
notes: GENE_ASSOCIATION: (220.1) or (218.1) or (221.1) or (222.1) or (U37519.1) SUBSYSTEM: Bile acid synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:12810727,PMID:6884990 NOTES:
name: glycine N-choloyltransferase EC:2.3.1.65
product: MODEL1310110061#
is version of: http://identifiers.org/ec-code/1.2.1.5
type: Reaction
fast: false
reversible: true
is described by: ECO:0000000
modifier: MODEL1310110061#
reactant: MODEL1310110061#
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110061#_c6ef3bda_8450_4535_a8f6_6fcfa6c834ad
constant: false
is: SBO:0000252
is: B1AM93
type: Species
is encoded by: hsa:4702
initial amount: NaN
initial concentration: NaN
has only substance units: false
boundary condition: true
name: NDUFA8

metaR CYTK8
is described by: ECO:0000269
product: MODEL1310110061#
reactant: MODEL1310110061#
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
is: SBO:0000176
fast: false
type: Reaction
reversible: true
is version of: http://identifiers.org/ec-code/2.7.4.14
modifier: MODEL1310110061#
name: cytidylate kinase (CMP,dATP)
kinetic law: MODEL1310110061#

http://identifiers.org/biomodels.db/MODEL1310110061#_fe68ca3a_141a_4363_9d26_162977146394
is encoded by: hsa:25769
has only substance units: false
boundary condition: true
type: Species
name: SLC24A2
is: SBO:0000252
initial amount: NaN
constant: false
is: Q9UI40
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110061#_2db2bb85_c054_4c3a_9156_55e1a4bb4cdf
boundary condition: true
is: SBO:0000252
initial amount: NaN
constant: false
name: COQ3
is encoded by: hsa:51805
has only substance units: false
type: Species
is: Q9NZJ6
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110061#_4ddfbb7b_cfe8_434e_9b76_0f6f88c9603d
is: Q15758
name: SLC1A5
has only substance units: false
constant: false
is encoded by: hsa:6510
type: Species
initial concentration: NaN
boundary condition: true
is: SBO:0000252
initial amount: NaN

metaR r1418
reactant: MODEL1310110061#
fast: false
is: SBO:0000176
name: Carbonic acid hydro-lyase Nitrogen metabolism EC:4.2.1.1
is described by: ECO:0000000
type: Reaction
kinetic law: MODEL1310110061#
product: MODEL1310110061#
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 4.2.1.1 Confidence Level: 0 AUTHORS: PMID:10938543,PMID:11493685,PMID:12713833,PMID:12747791,PMID:14640555,PMID:17259996,PMID:17504134,PMID:17826101,PMID:7011879,PMID:7672338 NOTES:
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110061#_244b11a7_a4ee_4859_a655_e7a594d14c2d
constant: false
type: Species
boundary condition: true
has only substance units: false
initial concentration: NaN
is: O00624
is encoded by: hsa:10246
initial amount: NaN
name: SLC17A2
is: SBO:0000252

metaM strdnc c
is: http://identifiers.org/pubchem.compound/47205608
name: stearidonic acid C18:4, n-3
type: Species
initial concentration: 1.0
has only substance units: false
initial amount: NaN
is: SBO:0000247
boundary condition: false
is: HMDB06547
notes: FORMULA: C18H27O2 CHARGE: -1 INCHI: InChI=1/C18H28O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20/h3-4,6-7,9-10,12-13H,2,5,8,11,14-17H2,1H3,(H,19,20)/b4-3-,7-6-,10-9-,13-12- HEPATONET_1.0_ABBREVIATION: HC00793
is: C16300
constant: false

metaR EX pect LPAREN e RPAREN
kinetic law: MODEL1310110061#
reactant: MODEL1310110061#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for pectins
type: Reaction

metaR AGTim
type: Reaction
name: alanine-glyoxylate transaminase (irreversible), mitochondrial
fast: false
product: MODEL1310110061#
modifier: MODEL1310110061#
reactant: MODEL1310110061#
is version of: http://identifiers.org/ec-code/2.6.1.44
reversible: false
is: SBO:0000176
notes: GENE_ASSOCIATION: (64902.1) or (64850.1) SUBSYSTEM: Alanine and aspartate metabolism EC Number: 2.6.1.44 Confidence Level: 4 AUTHORS: PMID:15240345,PMID:9038835,PMID:9783918 NOTES:NCD
kinetic law: MODEL1310110061#
is described by: ECO:0000269

metaM gthrd e
has only substance units: false
constant: false
notes: FORMULA: C10H16N3O6S CHARGE: -1 INCHI: InChI=1S/C10H17N3O6S/c11-5(10(18)19)1-2-7(14)13-6(4-20)9(17)12-3-8(15)16/h5-6,20H,1-4,11H2,(H,12,17)(H,13,14)(H,15,16)(H,18,19)/p-1/t5-,6-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00056 EHMN_ABBREVIATION: C00051
is: SBO:0000247
is: CHEBI:57925
initial amount: NaN
is: HMDB00125
initial concentration: 1.0
boundary condition: false
name: glutathionate(1-)
type: Species

metaR DM dttp n
kinetic law: MODEL1310110061#
reactant: MODEL1310110061#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 0 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: false
name: DM dttp(n)
type: Reaction

metaM 34hpp c
initial concentration: 1.0
constant: false
initial amount: NaN
has only substance units: false
notes: FORMULA: C9H7O4 CHARGE: -1 INCHI: InChI=1S/C9H8O4/c10-7-3-1-6(2-4-7)5-8(11)9(12)13/h1-4,10H,5H2,(H,12,13)/p-1 HEPATONET_1.0_ABBREVIATION: HC00699 EHMN_ABBREVIATION: C01179
is: HMDB00707
type: Species
is: SBO:0000247
name: 3-(4-hydroxyphenyl)pyruvate
boundary condition: false
is: CHEBI:36242

http://identifiers.org/biomodels.db/MODEL1310110061#_89fe5a56_7b68_469c_9af4_4aab8500d872
initial concentration: NaN
constant: false
boundary condition: true
is: SBO:0000252
has only substance units: false
type: Species
name: SLC25A5
initial amount: NaN
is encoded by: hsa:292
is: Q6NVC0

metaR r0822
name: Mitochondrial Carrier (MC) TCDB:2.A.29.2.2
is described by: ECO:0000000
kinetic law: MODEL1310110061#
notes: GENE_ASSOCIATION: (2194.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:10585886,PMID:14598172,PMID:17173541,PMID:18406340,PMID:4424886,PMID:4441366,PMID:5099217,PMID:8329439 NOTES:
product: MODEL1310110061#
modifier: MODEL1310110061#
is version of: http://identifiers.org/ec-code/2.3.1.85
is: SBO:0000185
reactant: MODEL1310110061#
reversible: true
fast: false
type: Reaction

metaM HC01603 c
is: CHEBI:57454
is: SBO:0000247
has only substance units: false
name: 10-Formyltetrahydrofolate
notes: FORMULA: C20H21N7O7 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00212 EHMN_ABBREVIATION: C00234
initial amount: NaN
initial concentration: 1.0
is: C00234
constant: false
boundary condition: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110061#_827b86ab_d175_4b72_9cad_802e62729294
constant: false
boundary condition: true
is: SBO:0000252
has only substance units: false
initial concentration: NaN
initial amount: NaN
name: PCBD1
is encoded by: hsa:5092
type: Species

http://identifiers.org/biomodels.db/MODEL1310110061#_77fdcddb_40d4_415e_8f97_627a4d4cf715
boundary condition: true
initial amount: NaN
is: SBO:0000252
name: ENTPD1
constant: false
is encoded by: hsa:953
initial concentration: NaN
is: Q86VV3
type: Species
has only substance units: false

metaM amp r
constant: false
has only substance units: false
initial amount: NaN
is: HMDB00045
initial concentration: 1.0
boundary condition: false
notes: FORMULA: C10H12N5O7P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00030 EHMN_ABBREVIATION: C00020
is: SBO:0000247
name: AMP
is: C00020
is: CHEBI:456215
type: Species

metaR r2362
is: SBO:0000185
reversible: true
product: MODEL1310110061#
kinetic law: MODEL1310110061#
fast: false
reactant: MODEL1310110061#
type: Reaction
name: Organic anion transporter 5 Utilized transport
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
is described by: ECO:0000000

metaR r2363
type: Reaction
kinetic law: MODEL1310110061#
fast: false
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
reactant: MODEL1310110061#
reversible: true
name: Organic anion transporter 5 Utilized transport
product: MODEL1310110061#
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110061#_bda2e773_0114_42ec_85d1_08599027eeeb
name: B3GNT3
has only substance units: false
initial amount: NaN
is: Q9Y2A9
is encoded by: hsa:10331
boundary condition: true
constant: false
is: SBO:0000252
type: Species
initial concentration: NaN

metaR EX Lcystin LPAREN e RPAREN
kinetic law: MODEL1310110061#
reactant: MODEL1310110061#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: L-Cystine exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110061#_4574c91f_7c0a_40a0_958d_45c7653ebf73
is encoded by: hsa:641371
has only substance units: false
initial concentration: NaN
boundary condition: true
initial amount: NaN
type: Species
is: SBO:0000252
is: E9KL42
constant: false
name: ACOT1

metaM glu L r
name: L-glutamate(1-)
boundary condition: false
notes: FORMULA: C5H8NO4 CHARGE: -1 INCHI: InChI=1S/C5H9NO4/c6-3(5(9)10)1-2-4(7)8/h3H,1-2,6H2,(H,7,8)(H,9,10)/p-1/t3-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00034 EHMN_ABBREVIATION: C00025
is: HMDB00148
type: Species
has only substance units: false
is: CHEBI:29985
initial amount: NaN
initial concentration: 1.0
is: SBO:0000247
constant: false

metaR CYTK9
is version of: http://identifiers.org/ec-code/2.7.4.14
modifier: MODEL1310110061#
is described by: ECO:0000269
reactant: MODEL1310110061#
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
kinetic law: MODEL1310110061#
name: cytidylate kinase (CMP,dCTP)
reversible: true
fast: false
is: SBO:0000176
type: Reaction
product: MODEL1310110061#

metaR CHOLtn
is: SBO:0000185
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: NOTES:it
fast: false
kinetic law: MODEL1310110061#
reactant: MODEL1310110061#
name: Choline transport, nuclear through pores
reversible: true
product: MODEL1310110061#
type: Reaction

metaR IZPN
type: Reaction
fast: false
name: Imidazolonepropionase
product: MODEL1310110061#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Histidine metabolism EC Number: Confidence Level: 4 AUTHORS: NOTES:
reactant: MODEL1310110061#
kinetic law: MODEL1310110061#
reversible: false
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110061#_0f11063c_fb56_408f_9226_b48435a39861
initial amount: NaN
type: Species
boundary condition: true
name: PLA2G4A
constant: false
is: P47712
initial concentration: NaN
is encoded by: hsa:5321
has only substance units: false
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110061#_ab1f51b5_b00e_46f8_ba59_019cfa2d30d9
initial concentration: NaN
boundary condition: true
has only substance units: false
type: Species
is: P43251
initial amount: NaN
name: BTD
constant: false
is: SBO:0000252
is encoded by: hsa:686

metaM sphs1p e
is: SBO:0000247
has only substance units: false
name: sphingosine 1-phosphate(1-)
initial amount: NaN
initial concentration: 1.0
boundary condition: false
is: CHEBI:60119
type: Species
constant: false
notes: FORMULA: C18H37NO5P CHARGE: -1 INCHI: InChI=1S/C18H38NO5P/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-18(20)17(19)16-24-25(21,22)23/h14-15,17-18,20H,2-13,16,19H2,1H3,(H2,21,22,23)/p-1/b15-14+/t17-,18+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01702 EHMN_ABBREVIATION: C06124
is: HMDB00277

metaR LEUKTRE4t
kinetic law: MODEL1310110061#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:
reversible: true
is: SBO:0000185
name: leukotriene E4 transport
is described by: ECO:0000000
product: MODEL1310110061#
type: Reaction
fast: false
reactant: MODEL1310110061#

metaR r0821
notes: GENE_ASSOCIATION: (2194.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:10585886,PMID:14598172,PMID:17173541,PMID:18406340,PMID:4424886,PMID:4441366,PMID:5099217,PMID:8329439 NOTES:
is described by: ECO:0000000
fast: false
product: MODEL1310110061#
name: Mitochondrial Carrier (MC) TCDB:2.A.29.2.2
reversible: true
reactant: MODEL1310110061#
modifier: MODEL1310110061#
is version of: http://identifiers.org/ec-code/2.3.1.85
type: Reaction
is: SBO:0000185
kinetic law: MODEL1310110061#

http://identifiers.org/biomodels.db/MODEL1310110061#_7d92cb3d_43a9_44c8_a9c9_cf50f2d993a4
is: SBO:0000252
name: MLYCD
constant: false
is encoded by: hsa:23417
has only substance units: false
boundary condition: true
initial concentration: NaN
is: O95822
initial amount: NaN
type: Species

http://identifiers.org/biomodels.db/MODEL1310110061#_75529e89_7fe7_41c6_80ba_da3abd9c6027
boundary condition: true
is: Q6ZWP6
is: SBO:0000252
is encoded by: hsa:27034
initial amount: NaN
initial concentration: NaN
has only substance units: false
name: ACAD8
type: Species
constant: false

metaR EX crm hs LPAREN e RPAREN
kinetic law: MODEL1310110061#
reactant: MODEL1310110061#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: N-acylsphingosine exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110061#_629218b3_1023_4ec3_bc8a_f5f44d35d3a1
is encoded by: hsa:203
name: AK1
initial amount: NaN
is: SBO:0000252
has only substance units: false
initial concentration: NaN
constant: false
is: P00568
boundary condition: true
type: Species

metaR DNDPt24m
modifier: MODEL1310110061#
reactant: MODEL1310110061#
notes: GENE_ASSOCIATION: (60386.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:11226231 NOTES:IT
reversible: false
is: SBO:0000185
type: Reaction
product: MODEL1310110061#
is described by: ECO:0000269
kinetic law: MODEL1310110061#
fast: false
name: dTDP transport via dADP antiport

metaR PECTCHLe
kinetic law: MODEL1310110061#
product: MODEL1310110061#
reactant: MODEL1310110061#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: Binding of pectins with taurocholate in the intestinal lumen, reducing serum cholsterol levels.
type: Reaction

metaM peamn c
is: CHEBI:225237
constant: false
notes: FORMULA: C8H12N CHARGE: 1 INCHI: InChI=1S/C8H11N/c9-7-6-8-4-2-1-3-5-8/h1-5H,6-7,9H2/p+1 EHMN_ABBREVIATION: C05332
is: HMDB12275
has only substance units: false
boundary condition: false
initial amount: NaN
is: SBO:0000247
initial concentration: 1.0
type: Species
name: 2-phenylethanaminium

metaR ADNt
kinetic law: MODEL1310110061#
name: adenosine facilated transport in cytosol
type: Reaction
reactant: MODEL1310110061#
modifier: MODEL1310110061#
notes: GENE_ASSOCIATION: (3177.1) or (2030.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10722669,PMID:12838422 NOTES:IT
is described by: ECO:0000269
product: MODEL1310110061#
fast: false
is: SBO:0000185
reversible: true

metaR r2368
reversible: true
fast: false
kinetic law: MODEL1310110061#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
is: SBO:0000185
reactant: MODEL1310110061#
is described by: ECO:0000000
product: MODEL1310110061#
name: Organic anion transporter 5 Utilized transport
type: Reaction

metaM HC02180 e
name: thromboxane-b2
is: SBO:0000247
initial concentration: 1.0
notes: FORMULA: C20H33O6 CHARGE: -1 INCHI: InChI=1S/C20H34O6/c1-2-3-6-9-15(21)12-13-18-16(17(22)14-20(25)26-18)10-7-4-5-8-11-19(23)24/h4,7,12-13,15-18,20-22,25H,2-3,5-6,8-11,14H2,1H3,(H,23,24)/b7-4-,13-12+/t15-,16-,17-,18+,20?/m0/s1 EHMN_ABBREVIATION: C05963
constant: false
type: Species
initial amount: NaN
boundary condition: false
has only substance units: false
is: CHEBI:28728

metaR r2115
reversible: true
is described by: ECO:0000000
kinetic law: MODEL1310110061#
type: Reaction
is: SBO:0000185
modifier: MODEL1310110061#
fast: false
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
reactant: MODEL1310110061#
product: MODEL1310110061#

metaM dgsn c
is: HMDB00085
notes: FORMULA: C10H13N5O4 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00280 EHMN_ABBREVIATION: C00330
has only substance units: false
initial amount: NaN
is: CHEBI:17172
is: C00330
name: Deoxyguanosine
initial concentration: 1.0
type: Species
constant: false
is: SBO:0000247
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110061#_f3a53999_89e3_4efd_aa0e_fd7c4b1c432d
constant: false
is: SBO:0000252
type: Species
is encoded by: hsa:113452
has only substance units: false
initial amount: NaN
boundary condition: true
is: Q969K7
initial concentration: NaN
name: TMEM54

metaM dhdascb c
is: HMDB01264
initial concentration: 1.0
name: dehydroascorbide(1-)
constant: false
has only substance units: false
type: Species
boundary condition: false
is: SBO:0000247
is: CHEBI:58070
notes: FORMULA: C6H6O6 CHARGE: 0 INCHI: InChI=1S/C6H5O6/c7-1-2(8)5-3(9)4(10)6(11)12-5/h2,7-8H,1H2/q-1 EHMN_ABBREVIATION: C00425
initial amount: NaN

metaM eicostetcoa c
is: SBO:0000247
is: C16164
type: Species
boundary condition: false
initial amount: NaN
name: eicosatetranoyl coenzyme A
notes: FORMULA: C41H62N7O17P3S CHARGE: -4 INCHI: InChI=1/C41H66N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-32(50)69-25-24-43-31(49)22-23-44-39(53)36(52)41(2,3)27-62-68(59,60)65-67(57,58)61-26-30-35(64-66(54,55)56)34(51)40(63-30)48-29-47-33-37(42)45-28-46-38(33)48/h5-6,8-9,11-12,14-15,28-30,34-36,40,51-52H,4,7,10,13,16-27H2,1-3H3,(H,43,49)(H,44,53)(H,57,58)(H,59,60)(H2,42,45,46)(H2,54,55,56)/b6-5-,9-8-,12-11-,15-14-/t30-,34-,35-,36?,40-/m1/s1
initial concentration: 1.0
constant: false
has only substance units: false

metaM amp x
is: SBO:0000247
is: C00020
type: Species
is: CHEBI:456215
initial amount: NaN
constant: false
has only substance units: false
is: HMDB00045
initial concentration: 1.0
notes: FORMULA: C10H12N5O7P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00030 EHMN_ABBREVIATION: C00020
boundary condition: false
name: AMP

http://identifiers.org/biomodels.db/MODEL1310110061#_f17a3aca_d329_4acd_872d_b5a546dcfdc1
is: SBO:0000252
type: Species
initial concentration: NaN
constant: false
has only substance units: false
is: E2QRH8
initial amount: NaN
is encoded by: hsa:5332
name: PLCB4
boundary condition: true

metaM zymst r
notes: FORMULA: C27H44O CHARGE: 0 INCHI: InChI=1S/C27H44O/c1-18(2)7-6-8-19(3)23-11-12-24-22-10-9-20-17-21(28)13-15-26(20,4)25(22)14-16-27(23,24)5/h7,19-21,23-24,28H,6,8-17H2,1-5H3/t19-,20+,21+,23-,24+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01451 EHMN_ABBREVIATION: C05437
has only substance units: false
constant: false
is: SBO:0000247
is: CHEBI:18252
name: zymosterol
is: HMDB06271
boundary condition: false
initial concentration: 1.0
type: Species
initial amount: NaN

metaR PSSA1 hs
name: Phosphatidylserine synthase homo sapiens
notes: GENE_ASSOCIATION: (9791.1) SUBSYSTEM: Glycerophospholipid metabolism EC Number: 2.7.8.8 Confidence Level: 4 AUTHORS: NOTES:phosphatidylcholine as substrate NJ
reversible: true
product: MODEL1310110061#
modifier: MODEL1310110061#
is version of: http://identifiers.org/ec-code/2.7.8.29
reactant: MODEL1310110061#
is described by: ECO:0000269
fast: false
type: Reaction
is: SBO:0000176
kinetic law: MODEL1310110061#

metaR r1797
is described by: ECO:0000000
product: MODEL1310110061#
modifier: MODEL1310110061#
reversible: false
kinetic law: MODEL1310110061#
reactant: MODEL1310110061#
type: Reaction
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
name: Y+LAT2 Utilized transport
fast: false
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110061#_13144a73_121f_4152_916b_e3f6c4eb108a
type: Species
has only substance units: false
boundary condition: true
initial concentration: NaN
is: SBO:0000252
initial amount: NaN
name: SMPD3
constant: false
is: A8K0T6
is encoded by: hsa:55512

metaR r1583
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reactant: MODEL1310110061#
fast: false
is: SBO:0000185
kinetic law: MODEL1310110061#
type: Reaction
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
product: MODEL1310110061#
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110061#_67ba2a19_8ed4_4043_ac1e_5e38cd6b269f
type: Species
is encoded by: hsa:AI824319
initial amount: NaN
boundary condition: true
name: _AI824319_1_r
constant: false
is: SBO:0000252
has only substance units: false
initial concentration: NaN

metaR FACOAL160i
fast: false
modifier: MODEL1310110061#
is: SBO:0000176
reactant: MODEL1310110061#
kinetic law: MODEL1310110061#
product: MODEL1310110061#
is version of: http://identifiers.org/ec-code/6.2.1.3
name: C160 fatty acid activation
type: Reaction
notes: GENE_ASSOCIATION: (2181.2) or (22305.2) or (51703.1) or (22305.1) or (2180.1) or (2181.1) SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 4 AUTHORS: PMID:1531127 NOTES:TV catalyzed by acyl-CoA synthetases
reversible: false
is described by: ECO:0000269

metaR RE3326M
product: MODEL1310110061#
is: SBO:0000176
fast: false
reversible: true
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (594.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:2699399,PMID:9665099 NOTES:
kinetic law: MODEL1310110061#
type: Reaction
name: RE3326
is version of: http://identifiers.org/ec-code/1.2.4.4
modifier: MODEL1310110061#
reactant: MODEL1310110061#

MODEL1310110061
reaction: metaR RE0583C
species: metaM dctp m
species: metaM crm hs g
reaction: metaR GASNASE2ly
species: metaM hxan e
species: metaM coa m
species: metaM hexdectecoa m
species: metaM malcoa r
species: metaM tethex3coa c
species: metaM cholcoa x
species: metaM CE5236 c
reaction: metaR r0779
species: metaM 3mop e
reaction: metaR ALAt2r
species: metaM adp n
reaction: metaR EX arg L LPAREN e RPAREN
reaction: metaR ADRNCOAtx
reaction: metaR RE3245C
reaction: metaR HSD17B7r
species: metaM dcholcoa r
reaction: metaR r1627
reaction: metaR UDPG4E
reaction: metaR r1888
species: metaM Rtotal3 e
reaction: metaR r0630
reaction: metaR FAOXC2442246x
reaction: metaR GLYSNAT5tc
species: metaM dd2coa m
reaction: metaR q10h2tc
reaction: metaR CHOLt4
reaction: metaR r2435
reaction: metaR r1850
reaction: metaR FRDPtr
species: metaM glyc3p c
species: metaM ascb L c
reaction: metaR OROTGLUt
reaction: metaR r2519
reaction: metaR SO4tl
species: metaM 4abutn e
reaction: metaR EX HC02206 LPAREN e RPAREN
species: metaM retinol cis 11 c
reaction: metaR RE1709N
reaction: metaR EX ac LPAREN e RPAREN
reaction: metaR r1918
reaction: metaR EX hdca LPAREN e RPAREN
reaction: metaR RDH1
reaction: metaR r2081
reaction: metaR PNTK
reaction: metaR r2375
species: metaM 5adtststerones c
reaction: metaR ARACHDt2
reaction: metaR r1571
reaction: metaR NTD5m
reaction: metaR C226CRNt
reaction: metaR EX 2hb LPAREN e RPAREN
reaction: metaR FOLR2
reaction: metaR r0755
reaction: metaR UMPK5
reaction: metaR r1298
species: metaM mi1345p c
reaction: metaR DCSPTN1t
reaction: metaR LYSOXp
reaction: metaR r2115
species: metaM leuktrE4 c
species: metaM adp c
reaction: metaR HEX10
reaction: metaR EX inost LPAREN e RPAREN
species: metaM datp c
reaction: metaR PIPLC
species: metaM 4hbzcoa m
species: metaM HC02210 e
species: metaM 2octdectecoa m
reaction: metaR r2371
reaction: metaR r0578
reaction: metaR ACt2r
species: metaM sphmyln hs c
reaction: metaR r2420
reaction: metaR r1683
reaction: metaR HEX7
reaction: metaR PYK

metaR THFtm
kinetic law: MODEL1310110061#
reactant: MODEL1310110061#
is described by: ECO:0000000
type: Reaction
product: MODEL1310110061#
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: PMID:11375437 NOTES:NCD
name: 5,6,7,8-Tetrahydrofolate transport, diffusion, mitochondrial
is: SBO:0000185
fast: false

metaM fol c
is: HMDB00121
notes: FORMULA: C19H18N7O6 CHARGE: -1
initial amount: NaN
type: Species
is: SBO:0000247
has only substance units: false
boundary condition: false
initial concentration: 1.0
constant: false
name: Folate

metaR r2369
type: Reaction
is: SBO:0000185
reversible: true
kinetic law: MODEL1310110061#
reactant: MODEL1310110061#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
name: Organic anion transporter 5 Utilized transport
fast: false
product: MODEL1310110061#

metaM taur c
is: C00245
boundary condition: false
is: CHEBI:3544
initial concentration: 1.0
name: Taurine
initial amount: NaN
has only substance units: false
type: Species
notes: FORMULA: C2H7NO3S CHARGE: 0
is: HMDB00251
is: SBO:0000247
constant: false

metaM pchol hs c
name: Phosphatidylcholine
constant: false
notes: FORMULA: C8H18NO4PFULLRCO2FULLR2CO2 CHARGE: 0
initial amount: NaN
has only substance units: false
initial concentration: 1.0
is: SBO:0000247
boundary condition: false
is: CHEBI:16110
type: Species

metaR r2114
is: SBO:0000185
modifier: MODEL1310110061#
fast: false
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
reversible: true
is described by: ECO:0000000
kinetic law: MODEL1310110061#
type: Reaction
reactant: MODEL1310110061#
product: MODEL1310110061#

metaM bhb m
initial concentration: 1.0
initial amount: NaN
constant: false
type: Species
notes: FORMULA: C4H7O3 CHARGE: -1 INCHI: InChI=1S/C4H8O3/c1-3(5)2-4(6)7/h3,5H,2H2,1H3,(H,6,7)/p-1/t3-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00661 EHMN_ABBREVIATION: C01089
boundary condition: false
is: SBO:0000247
has only substance units: false
is: CHEBI:10983
is: HMDB00011
name: (R)-3-hydroxybutyrate

metaM HC01162 c
constant: false
is: CHEBI:58376
is: SBO:0000247
boundary condition: false
initial amount: NaN
type: Species
notes: FORMULA: C20H29N4O17P CHARGE: -2 INCHI: InChI=1S/C20H31N4O17P/c21-10-1-2-24(19(35)22-10)17-15(32)14(31)9(39-17)6-38-42(36,37)41-20(18(33)34)3-7(27)12(23-11(29)5-26)16(40-20)13(30)8(28)4-25/h1-2,7-9,12-17,25-28,30-32H,3-6H2,(H,23,29)(H,33,34)(H,36,37)(H2,21,22,35)/p-2/t7-,8+,9+,12+,13+,14+,15+,16+,17+,20+/m0/s1 EHMN_ABBREVIATION: C03691
initial concentration: 1.0
name: (2R,4S,5R,6R)-2-[({[(2R,3S,4R,5R)-5-(4-amino-2-oxo-1,2-dihydropyrimidin-1-yl)-3,4-dihydroxyoxolan-2-yl]methoxy}phosphinato)oxy]-4-hydroxy-5-(2-hydroxyacetamido)-6-[(1R,2R)-1,2,3-trihydroxypropyl]oxane-2-carboxylate
has only substance units: false

metaR CHOLtu
product: MODEL1310110061#
modifier: MODEL1310110061#
notes: GENE_ASSOCIATION: (6582.1) or (6584.1) or (6582.2) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12883891 NOTES:SAB electrogenic, Na indepdendent & rev
name: Choline uniport
is described by: ECO:0000269
type: Reaction
kinetic law: MODEL1310110061#
reversible: true
fast: false
is: SBO:0000185
reactant: MODEL1310110061#

metaR r2193
notes: GENE_ASSOCIATION: (6566.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
type: Reaction
fast: false
is: SBO:0000185
reversible: true
modifier: MODEL1310110061#
product: MODEL1310110061#
kinetic law: MODEL1310110061#
reactant: MODEL1310110061#
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.14
is described by: ECO:0000000

metaR EX meoh LPAREN e RPAREN
kinetic law: MODEL1310110061#
reactant: MODEL1310110061#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: methanol exchange
type: Reaction

metaM 1pyr5c c
has only substance units: false
initial concentration: 1.0
is: SBO:0000247
is: CHEBI:15893
type: Species
notes: FORMULA: C5H6NO2 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC01199 EHMN_ABBREVIATION: C03912
is: HMDB01301
is: C03912
boundary condition: false
name: 1-Pyrroline-5-carboxylate
initial amount: NaN
constant: false

http://identifiers.org/biomodels.db/MODEL1310110061#_06a82fa5_dfa3_48be_acc5_4373e7e1f158
type: Species
initial amount: NaN
boundary condition: true
initial concentration: NaN
constant: false
has only substance units: false
is encoded by: hsa:H53099
name: _H53099_1_m
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110061#_e6ab8fc5_bdd0_4f2c_9664_a7e02d334aab
boundary condition: true
is encoded by: hsa:51102
name: MECR
is: SBO:0000252
constant: false
type: Species
initial amount: NaN
is: Q9BV79
initial concentration: NaN
has only substance units: false

metaM succoa m
type: Species
notes: FORMULA: C25H35N7O19P3S CHARGE: -5 HEPATONET_1.0_ABBREVIATION: HC00093 EHMN_ABBREVIATION: C00091
boundary condition: false
constant: false
initial amount: NaN
is: CHEBI:57292
initial concentration: 1.0
name: Succinyl-CoA
is: SBO:0000247
is: HMDB01022
has only substance units: false

metaM hexccoa c
is: HMDB06459
is: SBO:0000247
notes: FORMULA: C47H82N7O17P3S CHARGE: -4 INCHI: InChI=1/C47H86N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-24-25-26-27-38(56)75-31-30-49-37(55)28-29-50-45(59)42(58)47(2,3)33-68-74(65,66)71-73(63,64)67-32-36-41(70-72(60,61)62)40(57)46(69-36)54-35-53-39-43(48)51-34-52-44(39)54/h34-36,40-42,46,57-58H,4-33H2,1-3H3,(H,49,55)(H,50,59)(H,63,64)(H,65,66)(H2,48,51,52)(H2,60,61,62)/p-4/t36-,40-,41-,42+,46-/m1/s1
initial amount: NaN
has only substance units: false
boundary condition: false
name: Hexacosanoyl-CoA (n-C26:0CoA)
type: Species
constant: false
initial concentration: 1.0

metaM fgam c
initial concentration: 1.0
boundary condition: false
is: HMDB01308
type: Species
initial amount: NaN
has only substance units: false
is: C04376
constant: false
notes: FORMULA: C8H13N2O9P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC01281 EHMN_ABBREVIATION: C04376
name: N2-Formyl-N1-(5-phospho-D-ribosyl)glycinamide
is: CHEBI:58426
is: SBO:0000247

metaR ADEt
type: Reaction
is described by: ECO:0000269
reversible: true
name: adenine reversible transport, cytosol
modifier: MODEL1310110061#
is: SBO:0000185
kinetic law: MODEL1310110061#
notes: GENE_ASSOCIATION: (3177.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12006583,PMID:12838422 NOTES:NCD
fast: false
product: MODEL1310110061#
reactant: MODEL1310110061#

metaM 3mop m
boundary condition: false
notes: FORMULA: C6H9O3 CHARGE: -1 INCHI: InChI=1S/C6H10O3/c1-3-4(2)5(7)6(8)9/h4H,3H2,1-2H3,(H,8,9)/p-1 HEPATONET_1.0_ABBREVIATION: HC01123 EHMN_ABBREVIATION: C00671
is: SBO:0000247
is: HMDB00491
is: CHEBI:28654
has only substance units: false
constant: false
initial concentration: 1.0
type: Species
initial amount: NaN
name: 3-methyl-2-oxopentanoate

metaM lac L c
is: CHEBI:16651
boundary condition: false
type: Species
name: (S)-lactate
initial amount: NaN
constant: false
initial concentration: 1.0
notes: FORMULA: C3H5O3 CHARGE: -1 INCHI: InChI=1S/C3H6O3/c1-2(4)3(5)6/h2,4H,1H3,(H,5,6)/p-1/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00177
is: SBO:0000247
has only substance units: false
is: HMDB00190

metaR UDPG4E
reactant: MODEL1310110061#
product: MODEL1310110061#
is: SBO:0000176
name: UDPglucose 4-epimerase
is version of: http://identifiers.org/ec-code/5.1.3.2
type: Reaction
is described by: ECO:0000134
modifier: MODEL1310110061#
kinetic law: MODEL1310110061#
reversible: true
fast: false
notes: GENE_ASSOCIATION: (2582.1) or (2582.2) SUBSYSTEM: Galactose metabolism EC Number: 5.1.3.2 Confidence Level: 0 AUTHORS: PMID:11117433 NOTES:used yeast system to overexpress gene to determine mutant kinetic properties

metaM 5adtststerone c
is: HMDB02961
initial amount: NaN
constant: false
notes: FORMULA: C19H30O2 CHARGE: 0 INCHI: InChI=1S/C19H30O2/c1-18-9-7-13(20)11-12(18)3-4-14-15-5-6-17(21)19(15,2)10-8-16(14)18/h12,14-17,21H,3-11H2,1-2H3/t12-,14-,15-,16-,17-,18-,19-/m0/s1 EHMN_ABBREVIATION: C03917
has only substance units: false
is: SBO:0000247
boundary condition: false
type: Species
initial concentration: 1.0
name: 17beta-hydroxy-5alpha-androstan-3-one
is: CHEBI:16330

metaM HC02180 c
type: Species
constant: false
initial concentration: 1.0
has only substance units: false
boundary condition: false
name: thromboxane-b2
is: CHEBI:28728
notes: FORMULA: C20H33O6 CHARGE: -1 INCHI: InChI=1S/C20H34O6/c1-2-3-6-9-15(21)12-13-18-16(17(22)14-20(25)26-18)10-7-4-5-8-11-19(23)24/h4,7,12-13,15-18,20-22,25H,2-3,5-6,8-11,14H2,1H3,(H,23,24)/b7-4-,13-12+/t15-,16-,17-,18+,20?/m0/s1 EHMN_ABBREVIATION: C05963
is: SBO:0000247
initial amount: NaN

metaR r2366
type: Reaction
kinetic law: MODEL1310110061#
name: Organic anion transporter 5 Utilized transport
reversible: true
reactant: MODEL1310110061#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
is described by: ECO:0000000
fast: false
product: MODEL1310110061#

metaR r2113
kinetic law: MODEL1310110061#
fast: false
is described by: ECO:0000000
type: Reaction
reversible: true
is: SBO:0000185
reactant: MODEL1310110061#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
modifier: MODEL1310110061#
product: MODEL1310110061#

metaM dhdascb e
constant: false
initial concentration: 1.0
name: dehydroascorbide(1-)
type: Species
is: SBO:0000247
is: CHEBI:58070
boundary condition: false
initial amount: NaN
has only substance units: false
notes: FORMULA: C6H6O6 CHARGE: 0 INCHI: InChI=1S/C6H5O6/c7-1-2(8)5-3(9)4(10)6(11)12-5/h2,7-8H,1H2/q-1 EHMN_ABBREVIATION: C00425
is: HMDB01264

metaM pchol hs e
boundary condition: false
name: Phosphatidylcholine
initial concentration: 1.0
initial amount: NaN
is: SBO:0000247
is: CHEBI:16110
has only substance units: false
type: Species
notes: FORMULA: C8H18NO4PFULLRCO2FULLR2CO2 CHARGE: 0
constant: false

metaR EX cmp LPAREN e RPAREN
kinetic law: MODEL1310110061#
reactant: MODEL1310110061#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: CMP exchange
type: Reaction

metaR EX co2 LPAREN e RPAREN
kinetic law: MODEL1310110061#
reactant: MODEL1310110061#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: CO2 exchange
type: Reaction

metaM 2decdicoa m
initial concentration: 1.0
type: Species
is: http://identifiers.org/pubchem.compound/16019966
initial amount: NaN
name: 2,7-decadienoylcoa
notes: FORMULA: C31H46N7O17P3S CHARGE: -4
constant: false
boundary condition: false
has only substance units: false
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110061#_89a84cd3_e390_4627_a2a6_fd270476e9d1
has only substance units: false
type: Species
boundary condition: true
is encoded by: hsa:3992
initial amount: NaN
is: SBO:0000252
initial concentration: NaN
constant: false
is: O60427
name: FADS1

metaR RE0830C
kinetic law: MODEL1310110061#
is: SBO:0000176
reversible: true
reactant: MODEL1310110061#
notes: GENE_ASSOCIATION: SUBSYSTEM: Tetrahydrobiopterin metabolism EC Number: 4.2.1.96 Confidence Level: 0 AUTHORS: PMID:10727395,PMID:1355046,PMID:1988938 NOTES:
name: RE0830
type: Reaction
is described by: ECO:0000000
product: MODEL1310110061#
fast: false

metaR r1580
reversible: true
type: Reaction
is described by: ECO:0000000
is: SBO:0000185
product: MODEL1310110061#
reactant: MODEL1310110061#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
kinetic law: MODEL1310110061#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1

http://identifiers.org/biomodels.db/MODEL1310110061#_13afcd7e_3cee_4e05_8cf0_243e8945687c
name: PRODH
type: Species
boundary condition: true
has only substance units: false
is: O43272
initial amount: NaN
is encoded by: hsa:5625
constant: false
is: SBO:0000252
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110061#_0d51e7a8_132d_447f_a6b6_1746aea5d73a
is: SBO:0000252
initial amount: NaN
type: Species
boundary condition: true
has only substance units: false
name: SRM
initial concentration: NaN
constant: false
is: P19623
is encoded by: hsa:6723

metaR HOMt4
type: Reaction
name: L-homoserine via sodium symport
product: MODEL1310110061#
reactant: MODEL1310110061#
kinetic law: MODEL1310110061#
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (6541.1) or (84889.1) or (6542.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:11591158,PMID:11891586,PMID:12049641,PMID:1348489,PMID:14770310,PMID:7534987,PMID:8954799 NOTES:SAB
reversible: false
is: SBO:0000185
fast: false
modifier: MODEL1310110061#

metaM xol7ah2al c
initial amount: NaN
has only substance units: false
is: HMDB06894
constant: false
name: 3alpha,7alpha-dihydroxy-5beta-cholestan-26-al
notes: FORMULA: C27H46O3 CHARGE: 0 INCHI: InChI=1S/C27H46O3/c1-17(16-28)6-5-7-18(2)21-8-9-22-25-23(11-13-27(21,22)4)26(3)12-10-20(29)14-19(26)15-24(25)30/h16-25,29-30H,5-15H2,1-4H3/t17?,18-,19+,20-,21-,22+,23+,24-,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01454 EHMN_ABBREVIATION: C05445
type: Species
initial concentration: 1.0
is: CHEBI:27428
boundary condition: false
is: SBO:0000247

metaM C04849 e
boundary condition: false
name: (5Z,9E,14Z)-(8xi,11R,12S)-11,12-epoxy-8-hydroxyicosa-5,9,14-trienoate
initial concentration: 1.0
is: CHEBI:57449
is: SBO:0000247
has only substance units: false
type: Species
initial amount: NaN
notes: FORMULA: C20H31O4 CHARGE: -1 INCHI: InChI=1S/C20H32O4/c1-2-3-4-5-6-10-13-18-19(24-18)16-15-17(21)12-9-7-8-11-14-20(22)23/h6-7,9-10,15-19,21H,2-5,8,11-14H2,1H3,(H,22,23)/p-1/b9-7-,10-6-,16-15+/t17?,18-,19+/m0/s1 EHMN_ABBREVIATION: C04849
constant: false

http://identifiers.org/biomodels.db/MODEL1310110061#_ad2c61e9_5af8_468a_befc_afbcc518bcb5
constant: false
initial amount: NaN
is encoded by: hsa:FLJ44968
name: _FLJ44968_1_m
is: SBO:0000252
initial concentration: NaN
boundary condition: true
type: Species
has only substance units: false

metaM uri n
name: uridine
boundary condition: false
notes: FORMULA: C9H12N2O6 CHARGE: 0 INCHI: InChI=1S/C9H12N2O6/c12-3-4-6(14)7(15)8(17-4)11-2-1-5(13)10-9(11)16/h1-2,4,6-8,12,14-15H,3H2,(H,10,13,16)/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00259 EHMN_ABBREVIATION: C00299
type: Species
is: CHEBI:16704
constant: false
initial amount: NaN
has only substance units: false
is: SBO:0000247
initial concentration: 1.0
is: HMDB00296

metaM xol7ah c
notes: FORMULA: C27H46O2 CHARGE: 0 INCHI: InChI=1S/C27H46O2/c1-17(2)7-6-8-18(3)21-9-10-22-25-23(12-14-27(21,22)5)26(4)13-11-20(28)15-19(26)16-24(25)29/h17-19,21-25,29H,6-16H2,1-5H3/t18-,19+,21-,22+,23+,24-,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01460 EHMN_ABBREVIATION: C05451
type: Species
constant: false
has only substance units: false
is: CHEBI:2290
is: SBO:0000247
is: HMDB06892
initial concentration: 1.0
boundary condition: false
name: 7alpha-hydroxy-5beta-cholestan-3-one
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110061#_7cd557f7_f1a3_4de0_bd9d_5a25e1b4302a
is encoded by: hsa:63917
initial concentration: NaN
is: B3KWF4
constant: false
type: Species
initial amount: NaN
is: SBO:0000252
boundary condition: true
has only substance units: false
name: GALNT11

metaR COQ5m
notes: GENE_ASSOCIATION: SUBSYSTEM: Ubiquinone synthesis EC Number: Confidence Level: 2 AUTHORS: PMID:10777520,PMID:1965190,PMID:7380842 NOTES:_2.1.1.- IT
name: Ubiquinone biosynthesis methyltransferase COQ5
type: Reaction
is described by: ECO:0000000
fast: false
reversible: false
kinetic law: MODEL1310110061#
reactant: MODEL1310110061#
is: SBO:0000176
product: MODEL1310110061#

metaR DESAT22 1p
fast: false
type: Reaction
is described by: ECO:0000000
kinetic law: MODEL1310110061#
product: MODEL1310110061#
name: fatty acyl-CoA desaturase (n-C22:4CoA -> n-C22:5CoA)
reversible: false
is: SBO:0000176
reactant: MODEL1310110061#
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid synthesis EC Number: 1.14.19.1 Confidence Level: 4 AUTHORS: NOTES:

metaR r2367
type: Reaction
is: SBO:0000185
reversible: true
kinetic law: MODEL1310110061#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
reactant: MODEL1310110061#
name: Organic anion transporter 5 Utilized transport
product: MODEL1310110061#
is described by: ECO:0000000
fast: false

metaM taur e
is: CHEBI:3544
boundary condition: false
initial amount: NaN
initial concentration: 1.0
name: Taurine
has only substance units: false
type: Species
is: SBO:0000247
constant: false
is: HMDB00251
is: C00245
notes: FORMULA: C2H7NO3S CHARGE: 0

metaR r2112
is: SBO:0000185
product: MODEL1310110061#
kinetic law: MODEL1310110061#
modifier: MODEL1310110061#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
is described by: ECO:0000000
type: Reaction
reversible: true
fast: false
reactant: MODEL1310110061#

metaR MI1PP
modifier: MODEL1310110061#
reversible: false
name: myo-inositol 1-phosphatase
reactant: MODEL1310110061#
is version of: http://identifiers.org/ec-code/3.1.3.25
is: SBO:0000176
notes: GENE_ASSOCIATION: (3612.1) or (3613.1) SUBSYSTEM: Inositol phosphate metabolism EC Number: 3.1.3.25 Confidence Level: 4 AUTHORS: PMID:1377913,PMID:2906139,PMID:9322233 NOTES:JLR
type: Reaction
fast: false
is described by: ECO:0000269
kinetic law: MODEL1310110061#
product: MODEL1310110061#

metaR r2195
type: Reaction
product: MODEL1310110061#
is: SBO:0000185
kinetic law: MODEL1310110061#
reactant: MODEL1310110061#
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.14
fast: false
notes: GENE_ASSOCIATION: (6566.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
is described by: ECO:0000000
reversible: true
modifier: MODEL1310110061#

metaM 4hexdtricoa m
initial concentration: 1.0
boundary condition: false
constant: false
has only substance units: false
is: HMDB02288
initial amount: NaN
notes: FORMULA: C37H56N7O17P3S CHARGE: -4
name: 4,7,10-hexadecatrienoylcoa
is: SBO:0000247
type: Species

metaM 2hexdtricoa m
notes: FORMULA: C37H56N7O17P3S CHARGE: -4
has only substance units: false
is: SBO:0000247
initial concentration: 1.0
initial amount: NaN
is: HMDB02288
boundary condition: false
constant: false
type: Species
name: 2,7,10-hexadecatrienoylcoa

metaM h2o x
is: C00001
initial amount: NaN
constant: false
boundary condition: false
is: CHEBI:15377
is: HMDB02111
name: H2O
type: Species
is: SBO:0000247
initial concentration: 1.0
notes: FORMULA: H2O CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00011 EHMN_ABBREVIATION: C00001
has only substance units: false

metaR EX fe3 LPAREN e RPAREN
kinetic law: MODEL1310110061#
reactant: MODEL1310110061#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Fe3+ exchange
type: Reaction

metaR r1581
type: Reaction
is described by: ECO:0000000
product: MODEL1310110061#
reactant: MODEL1310110061#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
kinetic law: MODEL1310110061#
is: SBO:0000185
reversible: true
fast: false

metaM udp r
notes: FORMULA: C9H11N2O12P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00025 EHMN_ABBREVIATION: C00015
is: C00015
initial concentration: 1.0
type: Species
constant: false
name: UDP
is: SBO:0000247
is: HMDB00295
is: CHEBI:58223
has only substance units: false
initial amount: NaN
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110061#_41ed824f_3c30_4c72_a118_e965dcaac717
initial concentration: NaN
is: SBO:0000252
type: Species
name: INPP5J
has only substance units: false
initial amount: NaN
is encoded by: hsa:27124
boundary condition: true
constant: false

http://identifiers.org/biomodels.db/MODEL1310110061#_f29445b9_b94b_4209_aa64_8029438df6e3
is encoded by: hsa:51181
is: Q7Z4W1
has only substance units: false
constant: false
is: SBO:0000252
initial concentration: NaN
initial amount: NaN
type: Species
name: DCXR
boundary condition: true

metaR ALATHRNaEx
reversible: false
modifier: MODEL1310110061#
name: L-alanine/L-threonine Na-dependent exchange (Ala-L in)
fast: false
product: MODEL1310110061#
is described by: ECO:0000269
type: Reaction
kinetic law: MODEL1310110061#
notes: GENE_ASSOCIATION: (6509.1) or (6510.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14530974 NOTES:SAB see Kanai and Hediger 2004 (2003), PMID 14530974
reactant: MODEL1310110061#
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110061#_7efa2ca8_bb1d_4f84_a1ef_842402932b54
is: Q99807
has only substance units: false
constant: false
boundary condition: true
name: COQ7
initial amount: NaN
type: Species
initial concentration: NaN
is encoded by: hsa:10229
is: SBO:0000252

metaR GLYCTDle
is: SBO:0000185
type: Reaction
reactant: MODEL1310110061#
reversible: true
is described by: ECO:0000134
fast: false
name: difussion of glycerol accross the brush border membrane
product: MODEL1310110061#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
kinetic law: MODEL1310110061#

metaR DNDPt34m
fast: false
kinetic law: MODEL1310110061#
type: Reaction
reactant: MODEL1310110061#
is described by: ECO:0000269
name: dGDP transport via dTDP antiport
is: SBO:0000185
reversible: false
product: MODEL1310110061#
notes: GENE_ASSOCIATION: (60386.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:11226231 NOTES:IT
modifier: MODEL1310110061#

http://identifiers.org/biomodels.db/MODEL1310110061#_8450f8d6_871f_4b7c_a9e4_0881856c1f9e
is: SBO:0000297
has only substance units: false
boundary condition: true
has part: Q86U05
is encoded by: hsa:23428
initial concentration: NaN
type: Species
initial amount: NaN
constant: false
name: SLC7A8:SLC3A2

metaR r1953
modifier: MODEL1310110061#
fast: false
product: MODEL1310110061#
reactant: MODEL1310110061#
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
name: Y+LAT2 Utilized transport
reversible: false
is described by: ECO:0000000
kinetic law: MODEL1310110061#
type: Reaction
is: SBO:0000185

metaR r2083
is: SBO:0000185
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
is described by: ECO:0000000
reversible: true
fast: false
modifier: MODEL1310110061#
type: Reaction
product: MODEL1310110061#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
kinetic law: MODEL1310110061#
reactant: MODEL1310110061#

metaR DGK1
is described by: ECO:0000269
name: deoxyguanylate kinase (dGMP:ATP)
fast: false
type: Reaction
is: SBO:0000176
modifier: MODEL1310110061#
is version of: http://identifiers.org/ec-code/2.7.4.8
reactant: MODEL1310110061#
notes: GENE_ASSOCIATION: (2987.1) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: NOTES:
kinetic law: MODEL1310110061#
reversible: true
product: MODEL1310110061#

metaR r0829
name: Mitochondrial Carrier (MC) TCDB:2.A.29.2.2
kinetic law: MODEL1310110061#
modifier: MODEL1310110061#
fast: false
reactant: MODEL1310110061#
notes: GENE_ASSOCIATION: (7389.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:10585886,PMID:14598172,PMID:4424886,PMID:4441366,PMID:5099217,PMID:8329439 NOTES:
is version of: http://identifiers.org/ec-code/4.1.1.37
is: SBO:0000185
product: MODEL1310110061#
is described by: ECO:0000000
type: Reaction
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110061#_f9c30e1e_d766_4e4a_a7ee_fe10705be4f2
boundary condition: true
is encoded by: hsa:AV717590
name: _AV717590_1_m
constant: false
type: Species
is: SBO:0000252
has only substance units: false
initial concentration: NaN
initial amount: NaN

metaR EX tmndnc LPAREN e RPAREN
kinetic law: MODEL1310110061#
reactant: MODEL1310110061#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: timnodonic acid exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110061#_77d254f1_df71_4c32_b323_d6087015e0e3
is: SBO:0000252
initial amount: NaN
constant: false
is encoded by: hsa:1120
is: Q9Y259
name: CHKB
type: Species
initial concentration: NaN
has only substance units: false
boundary condition: true

metaR 34HPPOR
notes: GENE_ASSOCIATION: (3242.1) SUBSYSTEM: Tyrosine metabolism EC Number: 1.13.11.27 Confidence Level: 4 AUTHORS: NOTES:
is version of: http://identifiers.org/ec-code/1.13.11.27
reactant: MODEL1310110061#
fast: false
name: 4-Hydroxyphenylpyruvate:oxygen oxidoreductase
is: SBO:0000176
modifier: MODEL1310110061#
reversible: false
kinetic law: MODEL1310110061#
product: MODEL1310110061#
is described by: ECO:0000269
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110061#_c19c4664_e51d_4155_9d93_ad72e81af91d
constant: false
has only substance units: false
type: Species
is: SBO:0000252
name: _AI934540_1_c
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:AI934540
boundary condition: true

metaR r1632
product: MODEL1310110061#
is: SBO:0000185
fast: false
reactant: MODEL1310110061#
kinetic law: MODEL1310110061#
is described by: ECO:0000000
reversible: true
type: Reaction
notes: GENE_ASSOCIATION: (57835.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
modifier: MODEL1310110061#

metaM 5mta e
is: HMDB01173
is: CHEBI:17509
is: SBO:0000247
boundary condition: false
initial amount: NaN
type: Species
name: 5-Methylthioadenosine
constant: false
has only substance units: false
initial concentration: 1.0
notes: FORMULA: C11H15N5O3S CHARGE: 0
is: C00170

metaM pristcoa c
initial amount: NaN
is: SBO:0000247
notes: FORMULA: C40H68N7O17P3S CHARGE: -4 INCHI: InChI=1/C40H72N7O17P3S/c1-25(2)11-8-12-26(3)13-9-14-27(4)15-10-16-28(5)39(52)68-20-19-42-30(48)17-18-43-37(51)34(50)40(6,7)22-61-67(58,59)64-66(56,57)60-21-29-33(63-65(53,54)55)32(49)38(62-29)47-24-46-31-35(41)44-23-45-36(31)47/h23-29,32-34,38,49-50H,8-22H2,1-7H3,(H,42,48)(H,43,51)(H,56,57)(H,58,59)(H2,41,44,45)(H2,53,54,55)/t26?,27?,28?,29-,32-,33-,34+,38-/m1/s1/f/h42-43,53-54,56,58H,41H2
boundary condition: false
initial concentration: 1.0
constant: false
type: Species
name: pristanoyl coa
is: CHEBI:51341
has only substance units: false

metaR MCLOR
reversible: true
fast: false
is: SBO:0000176
is described by: ECO:0000269
product: MODEL1310110061#
notes: GENE_ASSOCIATION: (92483.1) or (3945.1 and 3939.1) or (55293.1) or (3948.2) or (3948.1) or (3945.1) or (160287.1) or (3939.1) SUBSYSTEM: Methionine and cysteine metabolism EC Number: 1.1.1.27 Confidence Level: 4 AUTHORS: PMID:7054184 NOTES:
type: Reaction
name: 3-Mercaptolactate:NAD+ oxidoreductase
reactant: MODEL1310110061#
modifier: MODEL1310110061#
kinetic law: MODEL1310110061#
is version of: http://identifiers.org/ec-code/1.1.1.27

http://identifiers.org/biomodels.db/MODEL1310110061#_e94b4457_82ef_4806_82c1_3cbf8cc4d73d
initial amount: NaN
is: SBO:0000252
name: _H17063_1_c
boundary condition: true
constant: false
has only substance units: false
type: Species
is encoded by: hsa:H17063
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110061#_7df2aee6_1959_4f92_b7b3_ddb6ff23bdea
is: SBO:0000252
boundary condition: true
name: ACAA2
initial amount: NaN
is encoded by: hsa:10449
type: Species
initial concentration: NaN
is: P42765
has only substance units: false
constant: false

metaM triodthy c
has only substance units: false
is: HMDB00265
initial concentration: 1.0
boundary condition: false
constant: false
type: Species
name: 3,3',5-triiodo-L-thyronine
initial amount: NaN
is: CHEBI:18258
notes: FORMULA: C15H12I3NO4 CHARGE: 0 INCHI: InChI=1S/C15H12I3NO4/c16-9-6-8(1-2-13(9)20)23-14-10(17)3-7(4-11(14)18)5-12(19)15(21)22/h1-4,6,12,20H,5,19H2,(H,21,22)/t12-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00943 EHMN_ABBREVIATION: C02465
is: SBO:0000247

metaR r2084
reactant: MODEL1310110061#
kinetic law: MODEL1310110061#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
reversible: true
is described by: ECO:0000000
fast: false
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
product: MODEL1310110061#
type: Reaction
is: SBO:0000185
modifier: MODEL1310110061#

metaR EX akg LPAREN e RPAREN
kinetic law: MODEL1310110061#
reactant: MODEL1310110061#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 2-Oxoglutarate exchange
type: Reaction

metaR EX vitd3 LPAREN e RPAREN
kinetic law: MODEL1310110061#
reactant: MODEL1310110061#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for calctriol
type: Reaction

metaR r1857
kinetic law: MODEL1310110061#
product: MODEL1310110061#
type: Reaction
reactant: MODEL1310110061#
name: Y+LAT2 Utilized transport
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
fast: false
is described by: ECO:0000000
modifier: MODEL1310110061#
reversible: false
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110061#_0d42d0d9_2998_4e2a_b63a_6129e725185b
is: SBO:0000252
initial concentration: NaN
is: O00483
is encoded by: hsa:4697
has only substance units: false
type: Species
boundary condition: true
initial amount: NaN
name: NDUFA4
constant: false

metaR XOLDIOLONEt
is: SBO:0000185
reactant: MODEL1310110061#
product: MODEL1310110061#
name: lipid, flip-flop intracellular transport
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: PMID:12840657 NOTES:cholesterol precursor, transport by "diffusion" -> actually beleived to be flip-flop mechanism (PMID: 12840657). NJ
fast: false
reversible: true
kinetic law: MODEL1310110061#
type: Reaction
is described by: ECO:0000000

metaR MI14Ptn
product: MODEL1310110061#
reactant: MODEL1310110061#
name: inositol 1,4-bisphosphate nuclear transport (diffusion)
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD
kinetic law: MODEL1310110061#
reversible: true
is: SBO:0000185
type: Reaction
fast: false

http://identifiers.org/biomodels.db/MODEL1310110061#_abc8453b_7970_4420_a772_f7749c3daeac
is: Q7Z4L0
constant: false
initial concentration: NaN
type: Species
boundary condition: true
is encoded by: hsa:341947
is: SBO:0000252
name: COX8C
initial amount: NaN
has only substance units: false

metaR r0494
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Pyrimidine catabolism EC Number: 3.6.1.5 Confidence Level: 0 AUTHORS: PMID:15652174,PMID:16752921,PMID:17095758 NOTES:
is described by: ECO:0000000
fast: false
reactant: MODEL1310110061#
product: MODEL1310110061#
is: SBO:0000176
reversible: true
name: dTDP diphosphohydrolase Pyrimidine metabolism EC:3.6.1.5
kinetic law: MODEL1310110061#

metaR r1631
kinetic law: MODEL1310110061#
reversible: true
reactant: MODEL1310110061#
is described by: ECO:0000000
type: Reaction
is: SBO:0000185
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
product: MODEL1310110061#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1

metaR ADK3m
reversible: true
type: Reaction
is version of: http://identifiers.org/ec-code/2.7.4.10
is described by: ECO:0000269
fast: false
product: MODEL1310110061#
reactant: MODEL1310110061#
notes: GENE_ASSOCIATION: (50808.1) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: PMID:11485571 NOTES:NCD
modifier: MODEL1310110061#
is: SBO:0000176
kinetic law: MODEL1310110061#
name: adentylate kinase (GTP)

metaM 10fthf6glu e
type: Species
notes: FORMULA: C45H51N12O22 CHARGE: -7 INCHI: InChI=1/C45H58N12O22/c46-45-55-36-35(38(67)56-45)48-21(17-47-36)18-57(19-58)22-3-1-20(2-4-22)37(66)54-28(44(78)79)9-15-33(63)52-26(42(74)75)7-13-31(61)50-24(40(70)71)5-11-29(59)49-23(39(68)69)6-12-30(60)51-25(41(72)73)8-14-32(62)53-27(43(76)77)10-16-34(64)65/h1-4,19,21,23-28,48H,5-18H2,(H,49,59)(H,50,61)(H,51,60)(H,52,63)(H,53,62)(H,54,66)(H,64,65)(H,68,69)(H,70,71)(H,72,73)(H,74,75)(H,76,77)(H,78,79)(H4,46,47,55,56,67)/p-7/t21?,23?,24?,25?,26?,27?,28-/m1/s1
constant: false
initial concentration: 1.0
has only substance units: false
initial amount: NaN
boundary condition: false
is: HMDB00972
is: CHEBI:57454
is: SBO:0000247
name: 10-formyltetrahydrofolate-[Glu](6)

metaR 4HBZFm
product: MODEL1310110061#
fast: false
reactant: MODEL1310110061#
reversible: false
is described by: ECO:0000000
kinetic law: MODEL1310110061#
is: SBO:0000176
name: 4-hydroxybenzoate formation
notes: GENE_ASSOCIATION: SUBSYSTEM: Ubiquinone synthesis EC Number: Confidence Level: 2 AUTHORS: PMID:11583838,PMID:12232327 NOTES:IT reaction involved in formation of 4-hydroxybenzoate from tyrosine.
type: Reaction

metaR r2085
modifier: MODEL1310110061#
is described by: ECO:0000000
product: MODEL1310110061#
type: Reaction
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
fast: false
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
kinetic law: MODEL1310110061#
is: SBO:0000185
reactant: MODEL1310110061#
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110061#_8438d769_1d6d_4546_928f_20caadd22f1d
name: CMPK1
initial amount: NaN
initial concentration: NaN
is: SBO:0000252
boundary condition: true
constant: false
type: Species
is encoded by: hsa:51727
has only substance units: false
is: B2R6S5

metaR FAOXC165C164m
kinetic law: MODEL1310110061#
product: MODEL1310110061#
reactant: MODEL1310110061#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation (C16:5-->C16:4)m
type: Reaction

metaR GHMT2rm
name: glycine hydroxymethyltransferase, reversible, mitochondrial
fast: false
reactant: MODEL1310110061#
type: Reaction
notes: GENE_ASSOCIATION: (6472.1) SUBSYSTEM: Glycine, serine, alanine and threonine metabolism EC Number: 2.1.2.1 Confidence Level: 4 AUTHORS: PMID:8505317,PMID:8611185,PMID:9038835 NOTES:NCD
kinetic law: MODEL1310110061#
is: SBO:0000176
product: MODEL1310110061#
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/2.1.2.1
modifier: MODEL1310110061#
reversible: true

metaM 4hoxpacd c
initial concentration: 1.0
name: (4-hydroxyphenyl)acetaldehyde
notes: FORMULA: C8H8O2 CHARGE: 0 INCHI: InChI=1S/C8H8O2/c9-6-5-7-1-3-8(10)4-2-7/h1-4,6,10H,5H2 EHMN_ABBREVIATION: C03765
type: Species
has only substance units: false
constant: false
is: HMDB03767
boundary condition: false
initial amount: NaN
is: SBO:0000247
is: CHEBI:15621

metaR C4STMO1r
is version of: http://identifiers.org/ec-code/1.14.13.72
reversible: false
product: MODEL1310110061#
kinetic law: MODEL1310110061#
is: SBO:0000176
name: C-4 sterol methyl oxidase (4,4-dimethylzymosterol)
modifier: MODEL1310110061#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (6307.1) SUBSYSTEM: Cholesterol metabolism EC Number: Confidence Level: 4 AUTHORS: NOTES:EC 1.-.-.- NCD ER version NJ
fast: false
type: Reaction
reactant: MODEL1310110061#

http://identifiers.org/biomodels.db/MODEL1310110061#_01b6633b_5a35_4033_ac87_b8578d0273e2
initial amount: NaN
is encoded by: hsa:155184
boundary condition: true
constant: false
is: SBO:0000252
initial concentration: NaN
is: Q6PXP3
type: Species
has only substance units: false
name: SLC2A7

metaR r1630
product: MODEL1310110061#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
fast: false
kinetic law: MODEL1310110061#
is: SBO:0000185
reversible: true
reactant: MODEL1310110061#
is described by: ECO:0000000
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
type: Reaction

metaM nadph m
notes: FORMULA: C21H26N7O17P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00015 EHMN_ABBREVIATION: C00005
has only substance units: false
is: HMDB00221
initial concentration: 1.0
is: C00005
name: Nicotinamide adenine dinucleotide phosphate - reduced
constant: false
initial amount: NaN
is: SBO:0000247
is: CHEBI:57783
type: Species
boundary condition: false

metaM vitd3 e
is: CHEBI:28940
boundary condition: false
is: SBO:0000247
name: calciol
notes: FORMULA: C27H44O CHARGE: 0 INCHI: InChI=1S/C27H44O/c1-19(2)8-6-9-21(4)25-15-16-26-22(10-7-17-27(25,26)5)12-13-23-18-24(28)14-11-20(23)3/h12-13,19,21,24-26,28H,3,6-11,14-18H2,1-2,4-5H3/b22-12+,23-13-/t21-,24+,25-,26+,27-/m1/s1
initial amount: NaN
type: Species
has only substance units: false
is: HMDB00876
initial concentration: 1.0
constant: false

metaR EX 10fthf7glu LPAREN e RPAREN
kinetic law: MODEL1310110061#
reactant: MODEL1310110061#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 10-formyltetrahydrofolate-[Glu](7) exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110061#_d3eb0476_8067_40e6_a44f_9467b5316e9b
initial amount: NaN
name: HSD17B7
initial concentration: NaN
is: SBO:0000252
has only substance units: false
boundary condition: true
type: Species
is encoded by: hsa:51478
constant: false
is: P56937

http://identifiers.org/biomodels.db/MODEL1310110061#_c4ee551d_1ae1_4060_beda_d4d210feb931
boundary condition: true
initial amount: NaN
type: Species
name: DECR1
constant: false
has only substance units: false
initial concentration: NaN
is encoded by: hsa:1666
is: Q16698
is: SBO:0000252

metaR ELAIDt
product: MODEL1310110061#
kinetic law: MODEL1310110061#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11788354,PMID:12864740 NOTES:NJ
type: Reaction
reversible: true
is described by: ECO:0000000
fast: false
is: SBO:0000185
reactant: MODEL1310110061#
name: fatty acid transport via diffusion

metaM 5mta c
is: C00170
boundary condition: false
is: HMDB01173
has only substance units: false
is: CHEBI:17509
name: 5-Methylthioadenosine
is: SBO:0000247
type: Species
initial amount: NaN
initial concentration: 1.0
constant: false
notes: FORMULA: C11H15N5O3S CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00165 EHMN_ABBREVIATION: C00170

metaM lac L e
constant: false
name: (S)-lactate
has only substance units: false
boundary condition: false
initial amount: NaN
is: CHEBI:16651
notes: FORMULA: C3H5O3 CHARGE: -1 INCHI: InChI=1S/C3H6O3/c1-2(4)3(5)6/h2,4H,1H3,(H,5,6)/p-1/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00177
is: SBO:0000247
type: Species
is: HMDB00190
initial concentration: 1.0

metaR EX ppa LPAREN e RPAREN
kinetic law: MODEL1310110061#
reactant: MODEL1310110061#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Propionate exchange
type: Reaction

metaR RE2999M
notes: GENE_ASSOCIATION: (1632.1) or (10455.1) or (1962.1) SUBSYSTEM: Fatty acid oxidation EC Number: 5.3.3.8 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:7775433 NOTES:
product: MODEL1310110061#
type: Reaction
modifier: MODEL1310110061#
is version of: http://identifiers.org/ec-code/1.1.1.35
kinetic law: MODEL1310110061#
is version of: http://identifiers.org/ec-code/5.3.3.8
is: SBO:0000176
reversible: true
name: RE2999
fast: false
is described by: ECO:0000000
reactant: MODEL1310110061#

metaR r2086
is described by: ECO:0000000
kinetic law: MODEL1310110061#
reversible: true
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
fast: false
type: Reaction
is: SBO:0000185
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
product: MODEL1310110061#
modifier: MODEL1310110061#
reactant: MODEL1310110061#

metaM triodthy e
is: HMDB00265
constant: false
type: Species
has only substance units: false
initial concentration: 1.0
boundary condition: false
initial amount: NaN
name: 3,3',5-triiodo-L-thyronine
is: CHEBI:18258
is: SBO:0000247
notes: FORMULA: C15H12I3NO4 CHARGE: 0 INCHI: InChI=1S/C15H12I3NO4/c16-9-6-8(1-2-13(9)20)23-14-10(17)3-7(4-11(14)18)5-12(19)15(21)22/h1-4,6,12,20H,5,19H2,(H,21,22)/t12-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00943 EHMN_ABBREVIATION: C02465

metaR EX leu L LPAREN e RPAREN
kinetic law: MODEL1310110061#
reactant: MODEL1310110061#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: L-Leucine exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110061#_e437d600_7b54_4f3b_88bf_945a5eb97092
is: Q96DU7
type: Species
boundary condition: true
constant: false
name: ITPKC
initial amount: NaN
initial concentration: NaN
is: SBO:0000252
has only substance units: false
is encoded by: hsa:80271

metaR GGH 5THFe
reversible: false
type: Reaction
product: MODEL1310110061#
modifier: MODEL1310110061#
fast: false
is version of: http://identifiers.org/ec-code/3.4.19.9
kinetic law: MODEL1310110061#
notes: GENE_ASSOCIATION: (8836.1) SUBSYSTEM: Folate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:11375437,PMID:2867095,PMID:9614206 NOTES:REMOVES EITHER ONE OR TWO GLUTAMYL RESIDUES WITH A REACTION (WILL ONLY REPRESENT 1) - last step from 5-glutamyl to monoglutamyl is in one step IT
name: Gamma-glutamyl hydrolase (5THF), extracellular
is described by: ECO:0000000
is: SBO:0000176
reactant: MODEL1310110061#

http://identifiers.org/biomodels.db/MODEL1310110061#_b1467e96_15c7_4a52_94db_446c33ca22ae
constant: false
name: B3GALNT1
is encoded by: hsa:8706
initial amount: NaN
has only substance units: false
type: Species
is: B3KTQ4
initial concentration: NaN
boundary condition: true
is: SBO:0000252

metaR ADCim
name: Acetoacetate decarboxylation (irreversible), mitochondrial
product: MODEL1310110061#
kinetic law: MODEL1310110061#
type: Reaction
reversible: false
fast: false
reactant: MODEL1310110061#
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Propanoate metabolism EC Number: 4.1.1.4 Confidence Level: 2 AUTHORS: NOTES:TDV (Voet & Voet pg 581) Non-enzymatic decarboxylation; spontaneous reaction added "m" suffix - NCD
is described by: ECO:0000000

metaR r2003
fast: false
is: SBO:0000185
product: MODEL1310110061#
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
kinetic law: MODEL1310110061#
is described by: ECO:0000000
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.15
type: Reaction
reversible: false
modifier: MODEL1310110061#
reactant: MODEL1310110061#

metaR EX malttr LPAREN e RPAREN
kinetic law: MODEL1310110061#
reactant: MODEL1310110061#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Maltotriose exchange
type: Reaction

metaR SUCOAS1m
name: Succinate--CoA ligase (GDP-forming)
is described by: ECO:0000000
kinetic law: MODEL1310110061#
fast: false
modifier: MODEL1310110061#
notes: GENE_ASSOCIATION: (8802.1 and 8801.1) SUBSYSTEM: Citric acid cycle EC Number: 6.2.1.4 Confidence Level: 0 AUTHORS: PMID:9765291 NOTES:IF
is: SBO:0000176
reactant: MODEL1310110061#
is version of: http://identifiers.org/ec-code/6.2.1.4
type: Reaction
product: MODEL1310110061#
reversible: true

metaR FACOAL161
reversible: true
is: SBO:0000176
type: Reaction
notes: GENE_ASSOCIATION: (2180.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: NOTES:
fast: false
is version of: http://identifiers.org/ec-code/6.2.1.3
product: MODEL1310110061#
name: fatty-acid--CoA ligase (hexadecenoate)
kinetic law: MODEL1310110061#
is described by: ECO:0000000
modifier: MODEL1310110061#
reactant: MODEL1310110061#

metaM 2mop m
is: CHEBI:57700
has only substance units: false
is: SBO:0000247
initial amount: NaN
name: 2-methyl-3-oxopropanoate
initial concentration: 1.0
type: Species
notes: FORMULA: C4H5O3 CHARGE: -1 INCHI: InChI=1S/C4H6O3/c1-3(2-5)4(6)7/h2-3H,1H3,(H,6,7)/p-1 HEPATONET_1.0_ABBREVIATION: HC00296 EHMN_ABBREVIATION: C00349
boundary condition: false
constant: false
is: HMDB01172

metaR r2360
reversible: true
fast: false
type: Reaction
product: MODEL1310110061#
reactant: MODEL1310110061#
kinetic law: MODEL1310110061#
is: SBO:0000185
is described by: ECO:0000000
name: Organic anion transporter 5 Utilized transport
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110061#_9cea45cf_72c0_4621_979c_912f650636e7
initial amount: NaN
is: SBO:0000252
initial concentration: NaN
is encoded by: hsa:2571
constant: false
name: GAD1
boundary condition: true
has only substance units: false
type: Species
is: Q8IVA8

metaM 34hpp e
type: Species
boundary condition: false
initial amount: NaN
initial concentration: 1.0
is: SBO:0000247
name: 3-(4-hydroxyphenyl)pyruvate
has only substance units: false
is: HMDB00707
is: CHEBI:36242
notes: FORMULA: C9H7O4 CHARGE: -1 INCHI: InChI=1S/C9H8O4/c10-7-3-1-6(2-4-7)5-8(11)9(12)13/h1-4,10H,5H2,(H,12,13)/p-1
constant: false

metaR SPODMm
kinetic law: MODEL1310110061#
reversible: false
notes: GENE_ASSOCIATION: (6648.1) SUBSYSTEM: ROS detoxification EC Number: 1.15.1.1 Confidence Level: 2 AUTHORS: PMID:12649272,PMID:9376114 NOTES:TV (8-15-2003)
is: SBO:0000176
modifier: MODEL1310110061#
is described by: ECO:0000304
type: Reaction
product: MODEL1310110061#
name: superoxide dismutase
is version of: http://identifiers.org/ec-code/1.15.1.1
reactant: MODEL1310110061#
fast: false

metaR CITt4 4
name: citrate transport via sodium symport
reversible: true
modifier: MODEL1310110061#
kinetic law: MODEL1310110061#
is: SBO:0000185
is described by: ECO:0000006
fast: false
product: MODEL1310110061#
notes: GENE_ASSOCIATION: (284111.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12177002,PMID:12445824 NOTES:NCD
type: Reaction
reactant: MODEL1310110061#

metaR CYTK10
fast: false
product: MODEL1310110061#
reactant: MODEL1310110061#
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
is version of: http://identifiers.org/ec-code/2.7.4.14
modifier: MODEL1310110061#
is: SBO:0000176
reversible: true
is described by: ECO:0000269
name: cytidylate kinase (CMP,dGTP)
kinetic law: MODEL1310110061#
type: Reaction

metaM strdnc e
has only substance units: false
is: http://identifiers.org/pubchem.compound/47205608
constant: false
name: stearidonic acid C18:4, n-3
is: SBO:0000247
is: C16300
notes: FORMULA: C18H27O2 CHARGE: -1 INCHI: InChI=1/C18H28O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20/h3-4,6-7,9-10,12-13H,2,5,8,11,14-17H2,1H3,(H,19,20)/b4-3-,7-6-,10-9-,13-12- HEPATONET_1.0_ABBREVIATION: HC00793
boundary condition: false
type: Species
initial concentration: 1.0
is: HMDB06547
initial amount: NaN

metaM gthrd c
notes: FORMULA: C10H16N3O6S CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00056 EHMN_ABBREVIATION: C00051
has only substance units: false
is: C00051
boundary condition: false
is: HMDB00125
initial amount: NaN
is: CHEBI:57925
initial concentration: 1.0
is: SBO:0000247
type: Species
name: Reduced glutathione
constant: false

metaM vitd3 c
is: HMDB00876
notes: FORMULA: C27H44O CHARGE: 0 INCHI: InChI=1S/C27H44O/c1-19(2)8-6-9-21(4)25-15-16-26-22(10-7-17-27(25,26)5)12-13-23-18-24(28)14-11-20(23)3/h12-13,19,21,24-26,28H,3,6-11,14-18H2,1-2,4-5H3/b22-12+,23-13-/t21-,24+,25-,26+,27-/m1/s1
initial concentration: 1.0
type: Species
name: calciol
is: CHEBI:28940
initial amount: NaN
boundary condition: false
constant: false
is: SBO:0000247
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110061#_4fda74c7_00c2_42ad_a226_f23a82c350a6
is: SBO:0000252
constant: false
initial concentration: NaN
name: SQLE
type: Species
is: Q5HYI4
has only substance units: false
is encoded by: hsa:6713
boundary condition: true
initial amount: NaN

metaR ADPtx
is: SBO:0000185
type: Reaction
is described by: ECO:0000000
kinetic law: MODEL1310110061#
reactant: MODEL1310110061#
reversible: true
name: ADP transporter, peroxisomal
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 1 AUTHORS: NOTES:most likely NOT physiological - detailed information about the peroxisomal transporters has not yet been achieved - this transport is most likely dependent on a concomitant energy consuming reaction (human ABC peroxisomal transporters: PEX family - check in future for new research articles describing biochemistry and stoichiometry) NJ
fast: false
product: MODEL1310110061#

metaR 34DHPHEt
kinetic law: MODEL1310110061#
is: SBO:0000185
fast: false
reversible: true
modifier: MODEL1310110061#
notes: GENE_ASSOCIATION: (117247.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:11827462 NOTES:NCD
reactant: MODEL1310110061#
product: MODEL1310110061#
type: Reaction
is described by: ECO:0000269
name: 3,4-Dihydroxy-L-phenylalanine transport

metaM glu L m
initial amount: NaN
type: Species
notes: FORMULA: C5H8NO4 CHARGE: -1 INCHI: InChI=1S/C5H9NO4/c6-3(5(9)10)1-2-4(7)8/h3H,1-2,6H2,(H,7,8)(H,9,10)/p-1/t3-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00034 EHMN_ABBREVIATION: C00025
initial concentration: 1.0
name: L-glutamate(1-)
is: SBO:0000247
boundary condition: false
is: HMDB00148
constant: false
is: CHEBI:29985
has only substance units: false

metaR NDP7g
kinetic law: MODEL1310110061#
is: SBO:0000176
is described by: ECO:0000269
modifier: MODEL1310110061#
type: Reaction
reversible: false
fast: false
is version of: http://identifiers.org/ec-code/3.6.1.6
name: nucleoside-diphosphatase (UDP), Golgi apparatus
notes: GENE_ASSOCIATION: (9583.1) SUBSYSTEM: Nucleotide interconversion EC Number: 3.6.1.6 Confidence Level: 4 AUTHORS: PMID:10393803,PMID:10858452,PMID:9556635 NOTES:NCD
reactant: MODEL1310110061#
product: MODEL1310110061#

metaM HC02204 c
boundary condition: false
name: prostaglandin-b1
notes: FORMULA: C20H31O4 CHARGE: -1 INCHI: InChI=1S/C20H32O4/c1-2-3-6-9-17(21)14-12-16-13-15-19(22)18(16)10-7-4-5-8-11-20(23)24/h12,14,17,21H,2-11,13,15H2,1H3,(H,23,24)/b14-12+/t17-/m0/s1 EHMN_ABBREVIATION: C00959
has only substance units: false
initial amount: NaN
is: SBO:0000247
type: Species
is: CHEBI:27624
constant: false
initial concentration: 1.0

metaR r0267
reversible: true
is version of: http://identifiers.org/ec-code/3.5.1.9
modifier: MODEL1310110061#
name: CMP-N-acetylneuraminate,ferrocytochrome-b5:oxygen oxidoreductase (N-acetyl-hydroxylating) Aminosugars metabolism EC:1.14.18.2
is: SBO:0000176
fast: false
is described by: ECO:0000000
kinetic law: MODEL1310110061#
reactant: MODEL1310110061#
product: MODEL1310110061#
type: Reaction
notes: GENE_ASSOCIATION: (125061.1) SUBSYSTEM: Unassigned EC Number: 1.14.18.2 Confidence Level: 0 AUTHORS: PMID:11211935,PMID:2249689,PMID:8112313 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110061#_f19fc7c3_24f9_4af5_b3b7_67d6e507e631
is: P23743
is: SBO:0000252
initial amount: NaN
constant: false
type: Species
is encoded by: hsa:1606
boundary condition: true
initial concentration: NaN
has only substance units: false
name: DGKA

metaR r1636
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reversible: true
reactant: MODEL1310110061#
is described by: ECO:0000000
type: Reaction
modifier: MODEL1310110061#
kinetic law: MODEL1310110061#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
fast: false
is: SBO:0000185
product: MODEL1310110061#

http://identifiers.org/biomodels.db/MODEL1310110061#_7cfe85a2_ff8d_4bb8_b136_64771736effe
initial amount: NaN
has only substance units: false
name: RDH13
constant: false
type: Species
is: B3KVA3
boundary condition: true
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:112724

metaR UMPK3n
name: UMP kinase (UTP),nuclear
product: MODEL1310110061#
reactant: MODEL1310110061#
modifier: MODEL1310110061#
reversible: true
is version of: http://identifiers.org/ec-code/2.7.4.14
fast: false
kinetic law: MODEL1310110061#
is described by: ECO:0000269
type: Reaction
is: SBO:0000176
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110061#_64e93756_f90e_4c95_a108_a7e50791e5e7
initial amount: NaN
constant: false
has only substance units: false
name: SLC7A3
is encoded by: hsa:84889
boundary condition: true
is: SBO:0000252
is: Q8WY07
type: Species
initial concentration: NaN

metaR r2080
is: SBO:0000185
kinetic law: MODEL1310110061#
fast: false
reactant: MODEL1310110061#
modifier: MODEL1310110061#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
reversible: true
product: MODEL1310110061#
type: Reaction
name: Major Facilitator(MFS) TCDB:2.A.1.13.1

http://identifiers.org/biomodels.db/MODEL1310110061#_ea79e4ea_6c43_4edc_b24a_1df3fd9634f4
is: SBO:0000252
initial concentration: NaN
boundary condition: true
is encoded by: hsa:5091
type: Species
name: PC
has only substance units: false
constant: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110061#_3ad40a65_05d6_4498_96a4_e250c2621018
constant: false
is encoded by: hsa:AV727634
initial amount: NaN
boundary condition: true
initial concentration: NaN
is: SBO:0000252
has only substance units: false
name: _AV727634_1_c
type: Species

metaR r2361
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
reversible: true
is: SBO:0000185
type: Reaction
reactant: MODEL1310110061#
name: Organic anion transporter 5 Utilized transport
product: MODEL1310110061#
is described by: ECO:0000000
kinetic law: MODEL1310110061#

http://identifiers.org/biomodels.db/MODEL1310110061#_83c5bed5_c7ed_4af1_910d_6aa751ccec38
is: SBO:0000252
initial concentration: NaN
is encoded by: hsa:80025
has only substance units: false
name: PANK2
boundary condition: true
constant: false
type: Species
initial amount: NaN

metaR MMCDm
reactant: MODEL1310110061#
fast: false
kinetic law: MODEL1310110061#
modifier: MODEL1310110061#
is version of: http://identifiers.org/ec-code/4.1.1.9
notes: GENE_ASSOCIATION: (23417.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 4.1.1.9 Confidence Level: 1 AUTHORS: PMID:12123667,PMID:12955715 NOTES:JLR mitochondrial isoform - NCD
type: Reaction
reversible: false
is described by: ECO:0000212
product: MODEL1310110061#
is: SBO:0000176
name: Methylmalonyl-CoA decarboxylase, mitochondrial

metaM 3mop e
initial concentration: 1.0
is: SBO:0000247
type: Species
initial amount: NaN
is: HMDB00491
notes: FORMULA: C6H9O3 CHARGE: -1 INCHI: InChI=1S/C6H10O3/c1-3-4(2)5(7)6(8)9/h4H,3H2,1-2H3,(H,8,9)/p-1
name: 3-methyl-2-oxopentanoate
boundary condition: false
constant: false
is: CHEBI:28654
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110061#_55a73a3c_6560_4016_8922_84b394092551
type: Species
initial amount: NaN
is encoded by: hsa:5471
constant: false
boundary condition: true
has only substance units: false
name: PPAT
is: SBO:0000252
is: Q06203
initial concentration: NaN

metaM h2o r
is: C00001
type: Species
name: H2O
notes: FORMULA: H2O CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00011 EHMN_ABBREVIATION: C00001
initial concentration: 1.0
boundary condition: false
is: CHEBI:15377
is: SBO:0000247
has only substance units: false
constant: false
initial amount: NaN
is: HMDB02111

http://identifiers.org/biomodels.db/MODEL1310110061#_21bba5d6_08ce_4732_8411_e4f08f017b83
boundary condition: true
is encoded by: hsa:4722
initial concentration: NaN
has only substance units: false
constant: false
is: SBO:0000252
name: NDUFS3
type: Species
is: O75489
initial amount: NaN

metaR EX leuktrC4 LPAREN e RPAREN
kinetic law: MODEL1310110061#
reactant: MODEL1310110061#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Leukotriene C4 exchange
type: Reaction

metaM 13 cis retn r
is: D00348
is: SBO:0000247
initial concentration: 1.0
is: HMDB06219
is: http://identifiers.org/pubchem.compound/7847414
has only substance units: false
initial amount: NaN
name: 13-cis-retinoate
type: Species
boundary condition: false
notes: FORMULA: C20H27O2 CHARGE: -1 INCHI: InChI=1/C20H28O2/c1-15(8-6-9-16(2)14-19(21)22)11-12-18-17(3)10-7-13-20(18,4)5/h6,8-9,11-12,14H,7,10,13H2,1-5H3,(H,21,22)/b9-6+,12-11+,15-8+,16-14- EHMN_ABBREVIATION: CE2952
constant: false

metaR r0268
modifier: MODEL1310110061#
kinetic law: MODEL1310110061#
is version of: http://identifiers.org/ec-code/3.1.3.2
product: MODEL1310110061#
is version of: http://identifiers.org/ec-code/3.1.3.1
fast: false
reversible: true
is: SBO:0000176
name: cytidine monophospho-N-acetylneuraminic acid hydroxylase EC:1.14.18.2
notes: GENE_ASSOCIATION: (52.1) or (53.1) or (54.1) or (51205.1) or (55.1) or (AI191472.1) or (248.1) or (249.1) or (250.1) or (251.1) SUBSYSTEM: Unassigned EC Number: 1.14.18.2 Confidence Level: 0 AUTHORS: PMID:10052592,PMID:1964451,PMID:2249689 NOTES:
is described by: ECO:0000000
reactant: MODEL1310110061#
type: Reaction

metaM thp2c x
has only substance units: false
boundary condition: false
is: SBO:0000247
name: 1-piperideine-6-carboxylate
is: HMDB12130
type: Species
initial amount: NaN
notes: FORMULA: C6H8NO2 CHARGE: -1 INCHI: InChI=1S/C6H9NO2/c8-6(9)5-3-1-2-4-7-5/h4-5H,1-3H2,(H,8,9)/p-1 EHMN_ABBREVIATION: C00450
is: CHEBI:16987
constant: false
initial concentration: 1.0

metaR ACETONEt2
type: Reaction
is: SBO:0000185
notes: GENE_ASSOCIATION: (6566.1) or (9123.1) or (9194.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10510291,PMID:11101640,PMID:12739169,PMID:7835905,PMID:8476015,PMID:9425115,PMID:9508842,PMID:9649795,PMID:9786900,PMID:9824713 NOTES:NCD
modifier: MODEL1310110061#
kinetic law: MODEL1310110061#
reactant: MODEL1310110061#
product: MODEL1310110061#
is described by: ECO:0000269
name: acetone transport via proton symport
reversible: true
fast: false

http://identifiers.org/biomodels.db/MODEL1310110061#_94d4012b_ef4e_453c_ab2c_4af0fa590717
is encoded by: hsa:23236
name: PLCB1
has only substance units: false
boundary condition: true
initial amount: NaN
is: Q9NQ66
initial concentration: NaN
is: SBO:0000252
constant: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110061#_7acd4eac_8f67_42a9_865e_b1ac5850e861
name: MTHFD2
initial amount: NaN
constant: false
type: Species
boundary condition: true
is encoded by: hsa:10797
has only substance units: false
is: P13995
initial concentration: NaN
is: SBO:0000252

metaR AMPtp
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 0 AUTHORS: NOTES:"diffusion" NJ
is described by: ECO:0000000
reversible: true
fast: false
is: SBO:0000185
product: MODEL1310110061#
kinetic law: MODEL1310110061#
type: Reaction
reactant: MODEL1310110061#
name: AMP transporter, peroxisome

metaR FAOXC103C102m
kinetic law: MODEL1310110061#
product: MODEL1310110061#
reactant: MODEL1310110061#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C10:3-->C10:2)m
type: Reaction

metaR r1635
reactant: MODEL1310110061#
fast: false
is: SBO:0000185
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
kinetic law: MODEL1310110061#
type: Reaction
modifier: MODEL1310110061#
product: MODEL1310110061#
reversible: true
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1

metaR PAFHe
reversible: false
reactant: MODEL1310110061#
is: SBO:0000176
name: Platelet-activating factor acetylhydrolase
kinetic law: MODEL1310110061#
type: Reaction
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (7941.1) SUBSYSTEM: Glycerophospholipid metabolism EC Number: 3.1.1.47 Confidence Level: 4 AUTHORS: PMID:8675689 NOTES:NJ
modifier: MODEL1310110061#
product: MODEL1310110061#
is version of: http://identifiers.org/ec-code/3.1.1.47
fast: false

http://identifiers.org/biomodels.db/MODEL1310110061#_f8534843_df98_460b_86be_e878d14ce1e2
boundary condition: true
has only substance units: false
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:34
constant: false
type: Species
initial concentration: NaN
name: ACADM
is: P11310

metaM pmtcoa c
notes: FORMULA: C37H62N7O17P3S CHARGE: -4
initial amount: NaN
boundary condition: false
is: CHEBI:3454
type: Species
has only substance units: false
is: C00154
is: HMDB01338
is: SBO:0000247
constant: false
initial concentration: 1.0
name: Palmitoyl-CoA (n-C16:0CoA)

metaR ESTRONEtr
product: MODEL1310110061#
reactant: MODEL1310110061#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: NOTES:specific mechanism not known, proton dependence for trans-mit transport has been suggested, however directionality and stoichiometry has not yet been elucidated. see PMID: 12770731 and others NJ
name: estrone intracellular transport
type: Reaction
is: SBO:0000185
fast: false
kinetic law: MODEL1310110061#
is described by: ECO:0000000
reversible: true

metaR LNELDCCPT1
reactant: MODEL1310110061#
is: SBO:0000176
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/2.3.1.21
product: MODEL1310110061#
modifier: MODEL1310110061#
name: carnitine O-palmitoyltransferase
type: Reaction
reversible: false
notes: GENE_ASSOCIATION: (1375.1) or (1375.3) or (1375.4) or (126129.1) or (1374.1) or (1375.2) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.21 Confidence Level: 4 AUTHORS: NOTES:NJ
fast: false
kinetic law: MODEL1310110061#

metaR GLNCYSNaEx
product: MODEL1310110061#
modifier: MODEL1310110061#
name: L-cysteine/L-glutamine Na-dependent exchange (Gln-L in)
kinetic law: MODEL1310110061#
fast: false
reversible: false
type: Reaction
reactant: MODEL1310110061#
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (6510.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14530974 NOTES:SAB see Kanai and Hediger 2004 (2003), PMID 14530974
is: SBO:0000185

metaR RE2079R
name: RE2079
is described by: ECO:0000000
reversible: true
type: Reaction
kinetic law: MODEL1310110061#
reactant: MODEL1310110061#
is: SBO:0000176
product: MODEL1310110061#
notes: GENE_ASSOCIATION: SUBSYSTEM: Eicosanoid metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:10200320,PMID:11786541,PMID:8521498,PMID:9755286 NOTES:
fast: false

metaR r2081
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
is described by: ECO:0000000
is: SBO:0000185
reversible: true
modifier: MODEL1310110061#
fast: false
product: MODEL1310110061#
type: Reaction
kinetic law: MODEL1310110061#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
reactant: MODEL1310110061#

metaR STS1
fast: false
name: Steryl-sulfatase
reactant: MODEL1310110061#
is described by: ECO:0000269
reversible: false
notes: GENE_ASSOCIATION: (412.1) SUBSYSTEM: Steroid metabolism EC Number: 3.1.6.2 Confidence Level: 4 AUTHORS: PMID:2668275,PMID:6957717 NOTES:NJ
product: MODEL1310110061#
kinetic law: MODEL1310110061#
is: SBO:0000176
type: Reaction
is version of: http://identifiers.org/ec-code/3.1.6.2
modifier: MODEL1310110061#

metaM sucsal m
name: Succinic semialdehyde
is: CHEBI:57706
type: Species
is: HMDB01259
boundary condition: false
initial concentration: 1.0
has only substance units: false
initial amount: NaN
is: SBO:0000247
constant: false
notes: FORMULA: C4H5O3 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00210 EHMN_ABBREVIATION: C00232

metaR CYTK12
modifier: MODEL1310110061#
name: cytidylate kinase (dCMP,dCTP)
is version of: http://identifiers.org/ec-code/2.7.4.14
reversible: true
reactant: MODEL1310110061#
is: SBO:0000176
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
fast: false
type: Reaction
kinetic law: MODEL1310110061#
is described by: ECO:0000269
product: MODEL1310110061#

metaR EX bhb LPAREN e RPAREN
kinetic law: MODEL1310110061#
reactant: MODEL1310110061#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: (R)-3-Hydroxybutanoate transport via H+ symport
type: Reaction

metaR DTMPK
kinetic law: MODEL1310110061#
type: Reaction
notes: GENE_ASSOCIATION: (1841.1) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: NOTES:
name: dTMP kinase
is version of: http://identifiers.org/ec-code/2.7.4.9
fast: false
reversible: true
reactant: MODEL1310110061#
is: SBO:0000176
modifier: MODEL1310110061#
product: MODEL1310110061#
is described by: ECO:0000269

metaR r1959
name: Y+LAT2 Utilized transport
kinetic law: MODEL1310110061#
product: MODEL1310110061#
reversible: false
is described by: ECO:0000000
fast: false
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is: SBO:0000185
type: Reaction
modifier: MODEL1310110061#
reactant: MODEL1310110061#

metaM HC02204 e
boundary condition: false
name: prostaglandin-b1
notes: FORMULA: C20H31O4 CHARGE: -1 INCHI: InChI=1S/C20H32O4/c1-2-3-6-9-17(21)14-12-16-13-15-19(22)18(16)10-7-4-5-8-11-20(23)24/h12,14,17,21H,2-11,13,15H2,1H3,(H,23,24)/b14-12+/t17-/m0/s1 EHMN_ABBREVIATION: C00959
initial amount: NaN
has only substance units: false
is: SBO:0000247
constant: false
type: Species
is: CHEBI:27624
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110061#_a5a846a4_1da8_4e13_a88b_dd23b3a0d7ad
name: HPD
is: SBO:0000252
boundary condition: true
constant: false
has only substance units: false
is encoded by: hsa:3242
initial concentration: NaN
type: Species
is: B3KQ63
initial amount: NaN

metaM dgdp n
name: dGDP(2-)
has only substance units: false
constant: false
is: HMDB00960
boundary condition: false
type: Species
is: CHEBI:58595
is: SBO:0000247
initial concentration: 1.0
initial amount: NaN
notes: FORMULA: C10H12N5O10P2 CHARGE: -3 INCHI: InChI=1S/C10H15N5O10P2/c11-10-13-8-7(9(17)14-10)12-3-15(8)6-1-4(16)5(24-6)2-23-27(21,22)25-26(18,19)20/h3-6,16H,1-2H2,(H,21,22)(H2,18,19,20)(H3,11,13,14,17)/p-3/t4-,5+,6+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00305 EHMN_ABBREVIATION: C00361

http://identifiers.org/biomodels.db/MODEL1310110061#_e307f494_10ab_459e_ae98_e0c31bf7bf8f
has only substance units: false
boundary condition: true
is encoded by: hsa:27068
constant: false
initial concentration: NaN
initial amount: NaN
is: F8WDN9
name: PPA2
type: Species
is: SBO:0000252

metaR r1634
reversible: true
reactant: MODEL1310110061#
is described by: ECO:0000000
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
type: Reaction
kinetic law: MODEL1310110061#
product: MODEL1310110061#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
fast: false
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110061#_ac27f226_1e0c_40b7_bb84_6227f737574a
is: Q9BWD1
boundary condition: true
constant: false
initial concentration: NaN
initial amount: NaN
type: Species
has only substance units: false
name: ACAT2
is encoded by: hsa:39
is: SBO:0000252

metaR r2000
reactant: MODEL1310110061#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.15
is: SBO:0000185
product: MODEL1310110061#
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
kinetic law: MODEL1310110061#
reversible: false
modifier: MODEL1310110061#
is described by: ECO:0000000
type: Reaction
fast: false

metaR r0791
reactant: MODEL1310110061#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/4.2.1.107
fast: false
kinetic law: MODEL1310110061#
name: trans-Hex-2-enoyl-CoA reductase Fatty acid elongation in mitochondria EC:1.3.1.38
modifier: MODEL1310110061#
product: MODEL1310110061#
type: Reaction
reversible: true
is version of: http://identifiers.org/ec-code/1.1.1.35
notes: GENE_ASSOCIATION: (1962.1) or (3033.1) or (3028.1) or (3295.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.1.38 Confidence Level: 0 AUTHORS: PMID:12654921 NOTES:
is described by: ECO:0000000

metaM 3mop c
initial concentration: 1.0
boundary condition: false
notes: FORMULA: C6H9O3 CHARGE: -1 INCHI: InChI=1S/C6H10O3/c1-3-4(2)5(7)6(8)9/h4H,3H2,1-2H3,(H,8,9)/p-1 HEPATONET_1.0_ABBREVIATION: HC01123 EHMN_ABBREVIATION: C00671
has only substance units: false
is: HMDB00491
initial amount: NaN
is: CHEBI:28654
constant: false
type: Species
is: SBO:0000247
name: 3-methyl-2-oxopentanoate

metaR RE1903R
name: RE1903
reactant: MODEL1310110061#
type: Reaction
kinetic law: MODEL1310110061#
notes: GENE_ASSOCIATION: SUBSYSTEM: Vitamin A metabolism EC Number: 1.2.1.36 Confidence Level: 0 AUTHORS: PMID:10559215,PMID:11007799 NOTES:
is described by: ECO:0000000
product: MODEL1310110061#
reversible: true
fast: false
is: SBO:0000176

metaR LNELDCCPT2
notes: GENE_ASSOCIATION: (1376.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: NOTES:NJ
product: MODEL1310110061#
reversible: false
fast: false
name: carnitine transferase
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/2.3.1.21
type: Reaction
kinetic law: MODEL1310110061#
modifier: MODEL1310110061#
reactant: MODEL1310110061#
is: SBO:0000176

metaR CYTK7n
name: cytidylate kinase (CMP,UTP),nuclear
is: SBO:0000176
reversible: true
is version of: http://identifiers.org/ec-code/2.7.4.14
fast: false
modifier: MODEL1310110061#
is described by: ECO:0000269
type: Reaction
reactant: MODEL1310110061#
product: MODEL1310110061#
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
kinetic law: MODEL1310110061#

metaR r2082
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
fast: false
kinetic law: MODEL1310110061#
reactant: MODEL1310110061#
is described by: ECO:0000000
modifier: MODEL1310110061#
reversible: true
type: Reaction
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
product: MODEL1310110061#
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110061#_8710e9b9_64b2_4613_aff1_5e9cf79d69d4
has only substance units: false
is: P20020
type: Species
is encoded by: hsa:490
initial amount: NaN
name: ATP2B1
boundary condition: true
constant: false
is: SBO:0000252
initial concentration: NaN

metaR STS2
kinetic law: MODEL1310110061#
is version of: http://identifiers.org/ec-code/3.1.6.2
reversible: false
reactant: MODEL1310110061#
notes: GENE_ASSOCIATION: (412.1) SUBSYSTEM: Steroid metabolism EC Number: 3.1.6.2 Confidence Level: 4 AUTHORS: PMID:2668275,PMID:6957717 NOTES:NJ
name: Steryl-sulfatase
fast: false
modifier: MODEL1310110061#
is: SBO:0000176
type: Reaction
product: MODEL1310110061#
is described by: ECO:0000269

metaR EX 2hb LPAREN e RPAREN
kinetic law: MODEL1310110061#
reactant: MODEL1310110061#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 2-Hydroxybutyrate exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110061#_69be2789_d438_4143_a648_e780bbe38d75
initial amount: NaN
constant: false
has only substance units: false
boundary condition: true
initial concentration: NaN
name: _AI915649_1_c
is: SBO:0000252
is encoded by: hsa:AI915649
type: Species

metaM retfa c
is: SBO:0000247
notes: FORMULA: C20H29OFULLR2CO CHARGE: 0
is: CHEBI:50211
is: HMDB00305
name: fatty acid retinol
initial concentration: 1.0
boundary condition: false
has only substance units: false
constant: false
type: Species
initial amount: NaN

metaM apoC Lys btn c
is: CHEBI:32551
is: HMDB00182
notes: FORMULA: C16H27N4O3SX CHARGE: 0
is: SBO:0000247
initial amount: NaN
name: Holocarboxylase (biotin covalent bound to Lys residue of apoC)
constant: false
boundary condition: false
initial concentration: 1.0
type: Species
has only substance units: false

metaR CYTK11
reactant: MODEL1310110061#
is: SBO:0000176
reversible: true
fast: false
kinetic law: MODEL1310110061#
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
name: cytidylate kinase (dCMP,dGTP)
modifier: MODEL1310110061#
type: Reaction
is version of: http://identifiers.org/ec-code/2.7.4.14
is described by: ECO:0000269
product: MODEL1310110061#

http://identifiers.org/biomodels.db/MODEL1310110061#_3c068b25_6826_4c9f_9617_a89f49c0beea
name: _T83654_1_m
has only substance units: false
initial concentration: NaN
is encoded by: hsa:T83654
is: SBO:0000252
boundary condition: true
initial amount: NaN
type: Species
constant: false

http://identifiers.org/biomodels.db/MODEL1310110061#_a751eda9_479f_4690_95e8_498b3df46062
initial amount: NaN
is: SBO:0000252
is: P00374
name: DHFR
constant: false
type: Species
boundary condition: true
has only substance units: false
is encoded by: hsa:1719
initial concentration: NaN

metaR r1633
product: MODEL1310110061#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
kinetic law: MODEL1310110061#
reversible: true
reactant: MODEL1310110061#
is described by: ECO:0000000
is: SBO:0000185
type: Reaction
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:

metaR EX glu L LPAREN e RPAREN
kinetic law: MODEL1310110061#
reactant: MODEL1310110061#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: L-Glutamate exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110061#_0bb6bbdd_6fd7_4fff_8547_174fd701b3ba
is: P05091
initial concentration: NaN
name: ALDH2
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:217
constant: false
boundary condition: true
has only substance units: false
type: Species

metaR PIter
reversible: true
is: SBO:0000185
type: Reaction
is described by: ECO:0000212
kinetic law: MODEL1310110061#
modifier: MODEL1310110061#
fast: false
name: phosphate transport, endoplasmic reticulum
notes: GENE_ASSOCIATION: (2544.1) SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: PMID:11879177 NOTES:NCD
reactant: MODEL1310110061#
product: MODEL1310110061#

metaM prostgh2 r
initial concentration: 1.0
initial amount: NaN
constant: false
has only substance units: false
name: prostaglandin H2(1-)
type: Species
notes: FORMULA: C20H31O5 CHARGE: -1 INCHI: InChI=1S/C20H32O5/c1-2-3-6-9-15(21)12-13-17-16(18-14-19(17)25-24-18)10-7-4-5-8-11-20(22)23/h4,7,12-13,15-19,21H,2-3,5-6,8-11,14H2,1H3,(H,22,23)/p-1/b7-4-,13-12+/t15-,16+,17+,18-,19+/m0/s1 EHMN_ABBREVIATION: C00427
boundary condition: false
is: SBO:0000247
is: CHEBI:57405
is: HMDB01381

metaR ALAGLNNaEx
reversible: false
type: Reaction
kinetic law: MODEL1310110061#
fast: false
modifier: MODEL1310110061#
name: L-alanine/L-glutamine Na-dependent exchange (Ala-L in)
is: SBO:0000185
product: MODEL1310110061#
notes: GENE_ASSOCIATION: (6510.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14530974 NOTES:SAB see Kanai and Hediger 2004 (2003), PMID 14530974
is described by: ECO:0000269
reactant: MODEL1310110061#

http://identifiers.org/biomodels.db/MODEL1310110061#_ee587f2c_e543_4db1_8390_2acad34f7d31
is: SBO:0000252
initial amount: NaN
boundary condition: true
name: SLC5A9
has only substance units: false
initial concentration: NaN
constant: false
is: E9PAK4
is encoded by: hsa:200010
type: Species

metaM amp m
notes: FORMULA: C10H12N5O7P CHARGE: -2 INCHI: InChI=1S/C10H14N5O7P/c11-8-5-9(13-2-12-8)15(3-14-5)10-7(17)6(16)4(22-10)1-21-23(18,19)20/h2-4,6-7,10,16-17H,1H2,(H2,11,12,13)(H2,18,19,20)/p-2/t4-,6-,7-,10-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00030 EHMN_ABBREVIATION: C00020
is: HMDB00045
type: Species
is: CHEBI:456215
boundary condition: false
constant: false
is: SBO:0000247
name: AMP(2-)
initial concentration: 1.0
initial amount: NaN
has only substance units: false

metaM dgdp m
type: Species
is: SBO:0000247
initial amount: NaN
is: HMDB00960
boundary condition: false
name: dGDP(2-)
is: CHEBI:58595
initial concentration: 1.0
has only substance units: false
notes: FORMULA: C10H12N5O10P2 CHARGE: -3 INCHI: InChI=1S/C10H15N5O10P2/c11-10-13-8-7(9(17)14-10)12-3-15(8)6-1-4(16)5(24-6)2-23-27(21,22)25-26(18,19)20/h3-6,16H,1-2H2,(H,21,22)(H2,18,19,20)(H3,11,13,14,17)/p-3/t4-,5+,6+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00305 EHMN_ABBREVIATION: C00361
constant: false

metaR r1639
reactant: MODEL1310110061#
is described by: ECO:0000000
is: SBO:0000185
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
type: Reaction
reversible: true
fast: false
modifier: MODEL1310110061#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
kinetic law: MODEL1310110061#
product: MODEL1310110061#

metaR EX dha LPAREN e RPAREN
kinetic law: MODEL1310110061#
reactant: MODEL1310110061#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of glycerone
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110061#_fd3a6d7b_25ee_4f6a_bc7f_b36352be8c2f
name: CA13
initial amount: NaN
has only substance units: false
initial concentration: NaN
constant: false
type: Species
is: Q8N1Q1
is: SBO:0000252
is encoded by: hsa:377677
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110061#_cdfdb646_722e_4101_a4de_fdd60aa6b9e2
initial amount: NaN
name: B3GALT5
is encoded by: hsa:10317
is: SBO:0000252
has only substance units: false
constant: false
initial concentration: NaN
boundary condition: true
type: Species

metaR UDPDOLPT L
modifier: MODEL1310110061#
fast: false
product: MODEL1310110061#
is described by: ECO:0000000
is: SBO:0000176
name: UDPglucose:dolichyl-phosphate beta-D-glucosyltransferase (liver)
type: Reaction
is version of: http://identifiers.org/ec-code/2.4.1.117
reversible: false
kinetic law: MODEL1310110061#
notes: GENE_ASSOCIATION: (29880.1) SUBSYSTEM: N-glycan synthesis EC Number: 2.4.1.117 Confidence Level: 0 AUTHORS: PMID:8280060 NOTES:NCD
reactant: MODEL1310110061#

metaR HEXCCOAtx
fast: false
reactant: MODEL1310110061#
kinetic law: MODEL1310110061#
type: Reaction
reversible: true
is: SBO:0000185
name: fatty acid intracellular transport
product: MODEL1310110061#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: NOTES:interaction between peroxisomes and ER (some enzymes on the outer membrane) NJ

http://identifiers.org/biomodels.db/MODEL1310110061#_00a5aaad_63ee_45e2_9dda_30aa592f0079
has only substance units: false
initial concentration: NaN
constant: false
type: Species
is: O95864
is: SBO:0000252
initial amount: NaN
name: FADS2
is encoded by: hsa:9415
boundary condition: true

metaR EX taur LPAREN e RPAREN
kinetic law: MODEL1310110061#
reactant: MODEL1310110061#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Taurine exchange
type: Reaction

metaR GALt2 2
reversible: true
is: SBO:0000185
is described by: ECO:0000269
reactant: MODEL1310110061#
modifier: MODEL1310110061#
name: D-galactose transport via proton symport
notes: GENE_ASSOCIATION: (6523.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:11024018,PMID:11034615,PMID:12748858,PMID:2490366,PMID:8063771 NOTES:
kinetic law: MODEL1310110061#
type: Reaction
product: MODEL1310110061#
fast: false

http://identifiers.org/biomodels.db/MODEL1310110061#_1af1cdc8_72af_4a0a_a95b_54c50d67e05c
initial amount: NaN
is: A0S0A7
has only substance units: false
constant: false
is: SBO:0000252
is encoded by: hsa:4846
name: NOS3
type: Species
boundary condition: true
initial concentration: NaN

metaM amp c
boundary condition: false
name: AMP
notes: FORMULA: C10H12N5O7P CHARGE: -2
initial amount: NaN
constant: false
type: Species
has only substance units: false
is: HMDB00045
initial concentration: 1.0
is: CHEBI:3322
is: SBO:0000247
is: C00020

http://identifiers.org/biomodels.db/MODEL1310110061#_905a49c5_d72a_486e_b931_5f084632a5d6
constant: false
initial concentration: NaN
name: RPE
is: SBO:0000252
boundary condition: true
is encoded by: hsa:6120
type: Species
initial amount: NaN
has only substance units: false
is: Q96AT9

metaR CERT2gt
type: Reaction
notes: GENE_ASSOCIATION: (10087.1) SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 2 AUTHORS: PMID:12803919,PMID:14685229,PMID:15596449,PMID:15907394 NOTES:non-vesicular intracellular transport of glucocerebroside
is: SBO:0000185
kinetic law: MODEL1310110061#
modifier: MODEL1310110061#
reversible: true
is version of: http://identifiers.org/ec-code/2.7.11.1
fast: false
product: MODEL1310110061#
reactant: MODEL1310110061#
name: ceramide transport protein
is described by: ECO:0000000

metaM aicar e
initial amount: NaN
is: C04677
name: 5-Amino-1-(5-Phospho-D-ribosyl)imidazole-4-carboxamide
has only substance units: false
notes: FORMULA: C9H13N4O8P CHARGE: -2
is: CHEBI:58475
constant: false
is: HMDB01517
boundary condition: false
is: SBO:0000247
type: Species
initial concentration: 1.0

metaR RE2660N
is: SBO:0000176
fast: false
kinetic law: MODEL1310110061#
type: Reaction
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (5092.1) or (84105.1) SUBSYSTEM: Tetrahydrobiopterin metabolism EC Number: 4.2.1.96 Confidence Level: 0 AUTHORS: PMID:8921004 NOTES:
name: RE2660
reversible: true
is version of: http://identifiers.org/ec-code/4.2.1.96
product: MODEL1310110061#
modifier: MODEL1310110061#
reactant: MODEL1310110061#

metaM prostgf2 c
is: SBO:0000247
name: prostaglandin F2alpha(1-)
notes: FORMULA: C20H33O5 CHARGE: -1 INCHI: InChI=1S/C20H34O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h4,7,12-13,15-19,21-23H,2-3,5-6,8-11,14H2,1H3,(H,24,25)/p-1/b7-4-,13-12+/t15-,16+,17+,18-,19+/m0/s1 EHMN_ABBREVIATION: C00639
initial concentration: 1.0
is: CHEBI:57404
initial amount: NaN
has only substance units: false
constant: false
boundary condition: false
is: HMDB01139
type: Species

metaR CYSTHRNaEx
name: L-cysteine/L-threonine Na-dependent exchange (Cys-L in)
type: Reaction
kinetic law: MODEL1310110061#
reactant: MODEL1310110061#
is: SBO:0000185
product: MODEL1310110061#
fast: false
notes: GENE_ASSOCIATION: (6509.1) or (6510.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14530974 NOTES:SAB see Kanai and Hediger 2004 (2003), PMID 14530974
modifier: MODEL1310110061#
is described by: ECO:0000269
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110061#_f794b215_74f2_4b9d_bfb6_8b9286ba2a1d
initial concentration: NaN
type: Species
boundary condition: true
is: SBO:0000252
name: PANK1
is: Q8TE04
has only substance units: false
constant: false
is encoded by: hsa:53354
initial amount: NaN

metaR EX 4nph LPAREN e RPAREN
kinetic law: MODEL1310110061#
reactant: MODEL1310110061#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 4-Nitrophenol exchange
type: Reaction

metaM CE0849 m
has only substance units: false
is: CHEBI:57795
boundary condition: false
name: cis,cis-palmito-7,10-dienoyl-CoA
initial amount: NaN
initial concentration: 1.0
type: Species
constant: false
notes: FORMULA: C37H58N7O17P3S CHARGE: -4 INCHI: InChI=1/C37H62N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-28(46)65-21-20-39-27(45)18-19-40-35(49)32(48)37(2,3)23-58-64(55,56)61-63(53,54)57-22-26-31(60-62(50,51)52)30(47)36(59-26)44-25-43-29-33(38)41-24-42-34(29)44/h8-9,11-12,24-26,30-32,36,47-48H,4-7,10,13-23H2,1-3H3,(H,39,45)(H,40,49)(H,53,54)(H,55,56)(H2,38,41,42)(H2,50,51,52)/p-4/b9-8-,12-11-/t26-,30+,31+,32u,36-/m0/s1 EHMN_ABBREVIATION: CE0849
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110061#_cdf87250_0c9a_4793_ba65_f3567810faa5
boundary condition: true
has only substance units: false
is: SBO:0000252
initial concentration: NaN
name: _AI971036_1_c
type: Species
is encoded by: hsa:AI971036
constant: false
initial amount: NaN

metaM xol7aone m
is: SBO:0000247
initial amount: NaN
name: 7alpha-hydroxycholest-4-en-3-one
initial concentration: 1.0
is: CHEBI:17899
has only substance units: false
constant: false
notes: FORMULA: C27H44O2 CHARGE: 0 INCHI: InChI=1S/C27H44O2/c1-17(2)7-6-8-18(3)21-9-10-22-25-23(12-14-27(21,22)5)26(4)13-11-20(28)15-19(26)16-24(25)29/h15,17-18,21-25,29H,6-14,16H2,1-5H3/t18-,21-,22+,23+,24-,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01464 EHMN_ABBREVIATION: C05455
is: HMDB01993
type: Species
boundary condition: false

metaR r1850
modifier: MODEL1310110061#
reversible: false
type: Reaction
kinetic law: MODEL1310110061#
fast: false
reactant: MODEL1310110061#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
product: MODEL1310110061#
is: SBO:0000185
name: Y+LAT2 Utilized transport

http://identifiers.org/biomodels.db/MODEL1310110061#_d4dd128f_2b16_441d_9931_0d60a8ca0f9b
type: Species
is: SBO:0000252
boundary condition: true
initial concentration: NaN
name: _HG2846_HT2983_1_m
is encoded by: hsa:HG2846-HT2983
initial amount: NaN
has only substance units: false
constant: false

metaM uri e
is: CHEBI:16704
type: Species
constant: false
is: HMDB00296
has only substance units: false
boundary condition: false
name: Uridine
is: C00299
notes: FORMULA: C9H12N2O6 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00259 EHMN_ABBREVIATION: C00299
is: SBO:0000247
initial amount: NaN
initial concentration: 1.0

metaM nadph c
name: Nicotinamide adenine dinucleotide phosphate - reduced
type: Species
constant: false
has only substance units: false
initial concentration: 1.0
is: HMDB00221
is: C00005
is: SBO:0000247
initial amount: NaN
notes: FORMULA: C21H26N7O17P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00015 EHMN_ABBREVIATION: C00005
boundary condition: false
is: CHEBI:57783

metaR 5MTAte
name: Transport of 5-S-methyl-5-thioadenosine
fast: false
is described by: ECO:0000134
kinetic law: MODEL1310110061#
type: Reaction
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
product: MODEL1310110061#
reactant: MODEL1310110061#
is: SBO:0000185

metaM lnlnca c
name: alpha-linolenate
constant: false
is: CHEBI:32387
is: HMDB01388
is: SBO:0000247
has only substance units: false
initial concentration: 1.0
notes: FORMULA: C18H29O2 CHARGE: -1 INCHI: InChI=1S/C18H30O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20/h3-4,6-7,9-10H,2,5,8,11-17H2,1H3,(H,19,20)/p-1/b4-3-,7-6-,10-9-
type: Species
boundary condition: false
initial amount: NaN

metaM dgdp c
is: C00361
notes: FORMULA: C10H12N5O10P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00305 EHMN_ABBREVIATION: C00361
name: dGDP
constant: false
is: HMDB00960
initial amount: NaN
boundary condition: false
type: Species
has only substance units: false
is: CHEBI:58595
is: SBO:0000247
initial concentration: 1.0

metaM pnto R e
is: CHEBI:7916
is: HMDB00210
type: Species
has only substance units: false
notes: FORMULA: C9H16NO5 CHARGE: -1 INCHI: InChI=1S/C9H17NO5/c1-9(2,5-11)7(14)8(15)10-4-3-6(12)13/h7,11,14H,3-5H2,1-2H3,(H,10,15)(H,12,13) HEPATONET_1.0_ABBREVIATION: HC00568
initial amount: NaN
initial concentration: 1.0
is: SBO:0000247
constant: false
boundary condition: false
name: (R)-Pantothenate

metaR EX 34hpp
kinetic law: MODEL1310110061#
reactant: MODEL1310110061#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: Exchange of 3-(4-hydroxyphenyl)pyruvate
type: Reaction

metaM phaccoa c
type: Species
has only substance units: false
constant: false
name: phenylacetyl-CoA(4-)
initial concentration: 1.0
is: HMDB06503
initial amount: NaN
is: CHEBI:57390
is: SBO:0000247
notes: FORMULA: C29H38N7O17P3S CHARGE: -4 INCHI: InChI=1S/C29H42N7O17P3S/c1-29(2,24(40)27(41)32-9-8-19(37)31-10-11-57-20(38)12-17-6-4-3-5-7-17)14-50-56(47,48)53-55(45,46)49-13-18-23(52-54(42,43)44)22(39)28(51-18)36-16-35-21-25(30)33-15-34-26(21)36/h3-7,15-16,18,22-24,28,39-40H,8-14H2,1-2H3,(H,31,37)(H,32,41)(H,45,46)(H,47,48)(H2,30,33,34)(H2,42,43,44)/p-4/t18-,22-,23-,24+,28-/m1/s1
boundary condition: false

metaR r0570
type: Reaction
reactant: MODEL1310110061#
product: MODEL1310110061#
notes: GENE_ASSOCIATION: (10588.1) or (400410.1) SUBSYSTEM: Pentose phosphate pathway EC Number: 5.4.2.7 Confidence Level: 0 AUTHORS: PMID:3023765 NOTES:
is: SBO:0000176
reversible: true
kinetic law: MODEL1310110061#
is version of: http://identifiers.org/ec-code/6.3.3.2
fast: false
modifier: MODEL1310110061#
is described by: ECO:0000000
name: 2-Deoxy-D-ribose 1-phosphate 1,5-phosphomutase Pentose phosphate pathway EC:5.4.2.7

metaM aacoa m
notes: FORMULA: C25H36N7O18P3S CHARGE: -4 INCHI: InChI=1S/C25H40N7O18P3S/c1-13(33)8-16(35)54-7-6-27-15(34)4-5-28-23(38)20(37)25(2,3)10-47-53(44,45)50-52(42,43)46-9-14-19(49-51(39,40)41)18(36)24(48-14)32-12-31-17-21(26)29-11-30-22(17)32/h11-12,14,18-20,24,36-37H,4-10H2,1-3H3,(H,27,34)(H,28,38)(H,42,43)(H,44,45)(H2,26,29,30)(H2,39,40,41)/p-4/t14-,18-,19-,20+,24-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00282 EHMN_ABBREVIATION: C00332
is: HMDB01484
name: acetoacetyl-CoA(4-)
initial amount: NaN
constant: false
boundary condition: false
is: SBO:0000247
has only substance units: false
is: CHEBI:57286
type: Species
initial concentration: 1.0

metaM 1pyr5c m
is: SBO:0000247
initial amount: NaN
is: HMDB01301
notes: FORMULA: C5H6NO2 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC01199 EHMN_ABBREVIATION: C03912
initial concentration: 1.0
type: Species
name: 1-Pyrroline-5-carboxylate
is: C03912
boundary condition: false
is: CHEBI:15893
constant: false
has only substance units: false

metaM prostge1 e
initial amount: NaN
has only substance units: false
initial concentration: 1.0
type: Species
constant: false
notes: FORMULA: C20H33O5 CHARGE: -1 INCHI: InChI=1S/C20H34O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h12-13,15-17,19,21,23H,2-11,14H2,1H3,(H,24,25)/p-1/b13-12+/t15-,16+,17+,19+/m0/s1 EHMN_ABBREVIATION: C04741
is: CHEBI:57397
name: prostaglandin E1(1-)
boundary condition: false
is: HMDB01442
is: SBO:0000247

metaR r1637
reactant: MODEL1310110061#
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
modifier: MODEL1310110061#
fast: false
product: MODEL1310110061#
is described by: ECO:0000000
is: SBO:0000185
type: Reaction
reversible: true
kinetic law: MODEL1310110061#

metaR FAOXTC142TC122m
kinetic law: MODEL1310110061#
product: MODEL1310110061#
reactant: MODEL1310110061#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation trans(C14:2-->C12:2)m
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110061#_af695e0b_1462_459b_b6ef_d7ab527baf21
type: Species
is encoded by: hsa:55568
initial amount: NaN
has only substance units: false
name: GALNT10
boundary condition: true
constant: false
initial concentration: NaN
is: SBO:0000252

metaR SO4tl
is described by: ECO:0000269
fast: false
is: SBO:0000185
type: Reaction
product: MODEL1310110061#
name: Sulfate transport (lysosome)
kinetic law: MODEL1310110061#
reactant: MODEL1310110061#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 1 AUTHORS: PMID:10535998,PMID:15607730 NOTES:
reversible: true

metaR IPDPtx
reactant: MODEL1310110061#
fast: false
is described by: ECO:0000134
kinetic law: MODEL1310110061#
type: Reaction
reversible: true
product: MODEL1310110061#
is: SBO:0000185
name: Isopentenyl diphosphate transport (peroxisome)
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: 5.3.3.2 Confidence Level: 1 AUTHORS: PMID:11111079 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110061#_6da1a1c0_4f75_412b_93a6_baeef2fabe8c
is: SBO:0000252
boundary condition: true
has only substance units: false
is: Q96PE7
is encoded by: hsa:84693
constant: false
initial amount: NaN
name: MCEE
type: Species
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110061#_661b3802_b85e_415a_90f3_18ce47980fa8
initial concentration: NaN
initial amount: NaN
name: MTMR3
has only substance units: false
is encoded by: hsa:8897
is: SBO:0000252
constant: false
type: Species
boundary condition: true

metaR r0488
product: MODEL1310110061#
reactant: MODEL1310110061#
reversible: true
is described by: ECO:0000000
kinetic law: MODEL1310110061#
name: (R)-Mevalonate:NADP+ oxidoreductase (CoA acylating) Biosynthesis of steroids EC:1.1.1.34
notes: GENE_ASSOCIATION: SUBSYSTEM: Cholesterol metabolism EC Number: 1.1.1.34 Confidence Level: 0 AUTHORS: PMID:10698924,PMID:11108725,PMID:12454262,PMID:3745272,PMID:3883347 NOTES:
is: SBO:0000176
fast: false
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110061#_dfe19d5b_b5af_4cf7_acf5_af10b817ea68
name: SLC2A13
is: SBO:0000252
initial concentration: NaN
has only substance units: false
constant: false
boundary condition: true
is: Q96QE2
is encoded by: hsa:114134
initial amount: NaN
type: Species

http://identifiers.org/biomodels.db/MODEL1310110061#_677dcd4a_9c7a_4cc9_b40d_64d0d00bfc29
is encoded by: hsa:4967
initial concentration: NaN
type: Species
is: SBO:0000252
initial amount: NaN
boundary condition: true
constant: false
name: OGDH
is: Q02218
has only substance units: false

metaM 5adtststerones c
name: 5alpha-Dihydrotestosterone sulfate
initial concentration: 1.0
is: HMDB06278
boundary condition: false
initial amount: NaN
has only substance units: false
constant: false
is: SBO:0000247
notes: FORMULA: C19H29O5S CHARGE: -1 INCHI: InChI=1/C19H30O5S/c1-18-9-7-13(20)11-12(18)3-4-14-15-5-6-17(24-25(21,22)23)19(15,2)10-8-16(14)18/h12,14-17H,3-11H2,1-2H3,(H,21,22,23)/t12-,14-,15-,16-,17-,18-,19-/m0/s1 EHMN_ABBREVIATION: CE6032
type: Species

http://identifiers.org/biomodels.db/MODEL1310110061#_d5427930_0a3c_450a_a81f_4a45ad63f23c
name: _AA854479_1_m
initial amount: NaN
is encoded by: hsa:AA854479
boundary condition: true
type: Species
has only substance units: false
is: SBO:0000252
constant: false
initial concentration: NaN

metaR PGISr
modifier: MODEL1310110061#
reactant: MODEL1310110061#
is: SBO:0000176
is described by: ECO:0000134
reversible: true
fast: false
name: Prostaglandin I2 synthase
type: Reaction
is version of: http://identifiers.org/ec-code/5.3.99.4
notes: GENE_ASSOCIATION: (5740.1) SUBSYSTEM: Eicosanoid metabolism EC Number: 5.3.99.4 Confidence Level: 4 AUTHORS: PMID:2120373,PMID:2491846 NOTES:NJ
kinetic law: MODEL1310110061#
product: MODEL1310110061#

metaR PLA2 2e
kinetic law: MODEL1310110061#
reactant: MODEL1310110061#
modifier: MODEL1310110061#
is described by: ECO:0000000
reversible: false
product: MODEL1310110061#
type: Reaction
fast: false
is version of: http://identifiers.org/ec-code/3.1.1.4
notes: GENE_ASSOCIATION: (5322.1) or (5319.1) or (81579.1) or (64600.1) or (26279.1) or (5320.1) or (8399.1) or (30814.1) SUBSYSTEM: Glycerophospholipid metabolism EC Number: 3.1.1.4 Confidence Level: 4 AUTHORS: PMID:10455175,PMID:10681567,PMID:11031251,PMID:11112443,PMID:8300559,PMID:9188469,PMID:9272153,PMID:9886417 NOTES:phosphatidyl choline degradation NJ
is: SBO:0000176
name: phospholipase A2

metaR CYOR u10m
reactant: MODEL1310110061#
type: Reaction
is described by: ECO:0000134
fast: false
modifier: MODEL1310110061#
product: MODEL1310110061#
kinetic law: MODEL1310110061#
is: SBO:0000185
is version of: http://identifiers.org/ec-code/3.5.1.92
name: ubiquinol-6 cytochrome c reductase, Complex III
notes: GENE_ASSOCIATION: (8876.1) and (8875.2) and (55350.3) or (8876.1) and (8875.2) and (55350.2) or (8876.1) and (8875.1) and (55350.1) or (8876.1) and (55350.2) and (8875.1) or (8875.2) and (8876.1) and (55350.1) or (8876.1) and (55350.3) and (8875.1) or (AA081045.1) or (AI620219.1) or (219.1) or (217.1) or (224.1) or (501.1) or (223.1) or (AU149534.1) or (T83654.1) SUBSYSTEM: Oxidative phosphorylation EC Number: Confidence Level: 4 AUTHORS: PMID:10453733,PMID:11047755 NOTES:INVALID ECO TERM: IFH
reversible: false
is version of: http://identifiers.org/ec-code/1.2.1.3

metaM mev R c
is: SBO:0000247
is: CHEBI:36464
is: HMDB00227
type: Species
boundary condition: false
name: (R)-mevalonate
initial concentration: 1.0
initial amount: NaN
notes: FORMULA: C6H11O4 CHARGE: -1 INCHI: InChI=1S/C6H12O4/c1-6(10,2-3-7)4-5(8)9/h7,10H,2-4H2,1H3,(H,8,9)/p-1/t6-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00343
has only substance units: false
constant: false

metaR UMPK2n
is described by: ECO:0000269
fast: false
name: UMP kinase (CTP),nuclear
product: MODEL1310110061#
is version of: http://identifiers.org/ec-code/2.7.4.14
is: SBO:0000176
type: Reaction
kinetic law: MODEL1310110061#
modifier: MODEL1310110061#
reactant: MODEL1310110061#
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110061#_3c325094_776a_429a_a006_6360ab62cdbd
has only substance units: false
boundary condition: true
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:8228
name: PNPLA4
type: Species
is: P41247
constant: false
is: SBO:0000252

metaR AICARte
type: Reaction
is described by: ECO:0000134
name: Transport of 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide(2-)
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
product: MODEL1310110061#
kinetic law: MODEL1310110061#
reversible: true
fast: false
reactant: MODEL1310110061#

metaR r1638
is: SBO:0000185
product: MODEL1310110061#
reactant: MODEL1310110061#
fast: false
kinetic law: MODEL1310110061#
is described by: ECO:0000000
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
modifier: MODEL1310110061#
type: Reaction
reversible: true
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:

metaM gmp g
type: Species
name: GMP(3-)
constant: false
is: SBO:0000247
is: HMDB01397
boundary condition: false
is: CHEBI:58115
has only substance units: false
initial amount: NaN
initial concentration: 1.0
notes: FORMULA: C10H12N5O8P CHARGE: -2 INCHI: InChI=1S/C10H14N5O8P/c11-10-13-7-4(8(18)14-10)12-2-15(7)9-6(17)5(16)3(23-9)1-22-24(19,20)21/h2-3,5-6,9,16-17H,1H2,(H2,19,20,21)(H3,11,13,14,18)/p-2/t3-,5-,6-,9-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00141 EHMN_ABBREVIATION: C00144

metaR CYTDtn
product: MODEL1310110061#
kinetic law: MODEL1310110061#
reactant: MODEL1310110061#
is: SBO:0000185
is described by: ECO:0000000
name: cytidine transport in nucleus
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: NOTES:IT
reversible: true
fast: false
type: Reaction

metaM uri c
constant: false
is: HMDB00296
initial amount: NaN
is: CHEBI:16704
is: SBO:0000247
notes: FORMULA: C9H12N2O6 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00259 EHMN_ABBREVIATION: C00299
is: C00299
has only substance units: false
type: Species
name: Uridine
initial concentration: 1.0
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110061#_31fe9236_f25c_4705_9ddf_d104cc4fc559
is: SBO:0000252
initial amount: NaN
is: Q9Y5P4
type: Species
constant: false
initial concentration: NaN
name: COL4A3BP
is encoded by: hsa:10087
boundary condition: true
has only substance units: false

metaR THRGLNexR
is: SBO:0000185
fast: false
product: MODEL1310110061#
reversible: true
is described by: ECO:0000304
reactant: MODEL1310110061#
modifier: MODEL1310110061#
name: L-threonine/glycine reversible exchange
notes: GENE_ASSOCIATION: (56301.1) and (6520.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10734121,PMID:10863037,PMID:14770310 NOTES:
type: Reaction
kinetic law: MODEL1310110061#

metaM 5adtststerones e
constant: false
initial amount: NaN
is: SBO:0000247
has only substance units: false
boundary condition: false
type: Species
notes: FORMULA: C19H29O5S CHARGE: -1 INCHI: InChI=1/C19H30O5S/c1-18-9-7-13(20)11-12(18)3-4-14-15-5-6-17(24-25(21,22)23)19(15,2)10-8-16(14)18/h12,14-17H,3-11H2,1-2H3,(H,21,22,23)/t12-,14-,15-,16-,17-,18-,19-/m0/s1 EHMN_ABBREVIATION: CE6032
name: 5alpha-Dihydrotestosterone sulfate
is: HMDB06278
initial concentration: 1.0

metaR EX octa LPAREN e RPAREN
kinetic law: MODEL1310110061#
reactant: MODEL1310110061#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for octanoate (n-C8:0)
type: Reaction

metaM pnto R c
boundary condition: false
notes: FORMULA: C9H16NO5 CHARGE: -1 INCHI: InChI=1S/C9H17NO5/c1-9(2,5-11)7(14)8(15)10-4-3-6(12)13/h7,11,14H,3-5H2,1-2H3,(H,10,15)(H,12,13) HEPATONET_1.0_ABBREVIATION: HC00568
is: SBO:0000247
initial concentration: 1.0
constant: false
has only substance units: false
name: (R)-Pantothenate
initial amount: NaN
is: CHEBI:7916
is: HMDB00210
type: Species

metaR EX 6dhf LPAREN e RPAREN
kinetic law: MODEL1310110061#
reactant: MODEL1310110061#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: haxglutamyl folate (DHF) exchange
type: Reaction

metaR MMEm
reversible: true
is version of: http://identifiers.org/ec-code/5.1.99.1
is: SBO:0000176
notes: GENE_ASSOCIATION: (84693.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 5.1.99.1 Confidence Level: 4 AUTHORS: PMID:11481338 NOTES:TDV
product: MODEL1310110061#
kinetic law: MODEL1310110061#
is described by: ECO:0000269
modifier: MODEL1310110061#
name: methylmalonyl-CoA epimerase/racemase
type: Reaction
reactant: MODEL1310110061#
fast: false

http://identifiers.org/biomodels.db/MODEL1310110061#_d083df65_3f09_4c4d_b834_10c0afedb715
boundary condition: true
constant: false
name: _8781_1_c
is encoded by: hsa:8781
is: SBO:0000252
type: Species
has only substance units: false
initial amount: NaN
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110061#_bfdc596f_85c0_49a3_9c28_5fbea3c4b14f
is: P42126
initial amount: NaN
is encoded by: hsa:1632
name: ECI1
constant: false
has only substance units: false
boundary condition: true
is: SBO:0000252
type: Species
initial concentration: NaN

metaM xol7aone r
boundary condition: false
has only substance units: false
is: SBO:0000247
is: CHEBI:17899
constant: false
name: 7alpha-hydroxycholest-4-en-3-one
notes: FORMULA: C27H44O2 CHARGE: 0 INCHI: InChI=1S/C27H44O2/c1-17(2)7-6-8-18(3)21-9-10-22-25-23(12-14-27(21,22)5)26(4)13-11-20(28)15-19(26)16-24(25)29/h15,17-18,21-25,29H,6-14,16H2,1-5H3/t18-,21-,22+,23+,24-,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01464 EHMN_ABBREVIATION: C05455
type: Species
initial amount: NaN
is: HMDB01993
initial concentration: 1.0

metaR PYDXDH
modifier: MODEL1310110061#
reactant: MODEL1310110061#
is: SBO:0000176
is described by: ECO:0000269
reversible: false
notes: GENE_ASSOCIATION: (316.1) SUBSYSTEM: Vitamin B6 metabolism EC Number: 1.2.3.1 Confidence Level: 4 AUTHORS: PMID:6380540 NOTES:IT
name: pyridoxal dehydrogenase
kinetic law: MODEL1310110061#
product: MODEL1310110061#
type: Reaction
is version of: http://identifiers.org/ec-code/1.2.3.1
fast: false

metaM apoC c
name: Apocarboxlase (no lys residue)
is: CHEBI:33190
initial concentration: 1.0
boundary condition: false
is: SBO:0000247
constant: false
has only substance units: false
notes: FORMULA: XH CHARGE: 0
type: Species
initial amount: NaN
is: HMDB11111

http://identifiers.org/biomodels.db/MODEL1310110061#_2e261c0b_02fd_4493_b5d5_bafba0fdd737
constant: false
initial concentration: NaN
initial amount: NaN
is: Q59F77
type: Species
is encoded by: hsa:5330
boundary condition: true
is: SBO:0000252
has only substance units: false
name: PLCB2

metaR RE3421R
product: MODEL1310110061#
name: RE3421
fast: false
is described by: ECO:0000000
kinetic law: MODEL1310110061#
type: Reaction
reversible: true
reactant: MODEL1310110061#
notes: GENE_ASSOCIATION: SUBSYSTEM: Eicosanoid metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:11786541,PMID:8521498 NOTES:
is: SBO:0000176

metaR LNLCCPT1
product: MODEL1310110061#
kinetic law: MODEL1310110061#
modifier: MODEL1310110061#
type: Reaction
reversible: false
is version of: http://identifiers.org/ec-code/2.3.1.21
name: carnitine O-palmitoyltransferase
notes: GENE_ASSOCIATION: (1375.1) or (1375.3) or (1375.4) or (126129.1) or (1374.1) or (1375.2) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.21 Confidence Level: 4 AUTHORS: NOTES:NJ
fast: false
reactant: MODEL1310110061#
is: SBO:0000176
is described by: ECO:0000269

http://identifiers.org/biomodels.db/MODEL1310110061#_7660413f_0bce_4a4c_b9ca_d3d1ee24c3ce
boundary condition: true
is: Q15181
type: Species
is encoded by: hsa:5464
name: PPA1
constant: false
initial amount: NaN
initial concentration: NaN
is: SBO:0000252
has only substance units: false

metaR THYOXt2
name: T4 transport via facilitated diffusion
kinetic law: MODEL1310110061#
modifier: MODEL1310110061#
fast: false
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (6567.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12871948,PMID:7981683 NOTES:NJ
type: Reaction
is: SBO:0000185
reactant: MODEL1310110061#
product: MODEL1310110061#
reversible: true

metaR r1010
reactant: MODEL1310110061#
product: MODEL1310110061#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:1735445,PMID:18406340,PMID:1988962,PMID:2351134,PMID:2355017,PMID:6361812,PMID:7892212,PMID:8132483 NOTES:
is described by: ECO:0000000
type: Reaction
kinetic law: MODEL1310110061#
name: Postulated transport reaction
reversible: true
is: SBO:0000185
fast: false

metaR ASPPROASCT1
notes: GENE_ASSOCIATION: (6509.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID: 14502423, PMID: 11824937, Kim E. Barrett, Mark Donowitz (2001) Gastrointestinal transport: Molecular physiology, Academic press, A harcourt science and technology company, chapter 10, pages 389-391. NOTES:ASCT-1 transport system operates at the basolateral surface, acts as an amino acid exchanger. Preferred substrates are small neutral amino acids, however shown to have transport proline and hydroxy-proline. At acidic ph also transports aspartate and glutamate. the ASCT-1 operates in a similar mechanism as ASCT-2.
fast: false
kinetic law: MODEL1310110061#
reactant: MODEL1310110061#
modifier: MODEL1310110061#
name: aspartate intake by system ASCT-1 transporter
product: MODEL1310110061#
is described by: ECO:0000134
reversible: false
type: Reaction
is: SBO:0000185

metaR ALAt2r
product: MODEL1310110061#
modifier: MODEL1310110061#
type: Reaction
reversible: true
is: SBO:0000185
name: L-alanine reversible transport via proton symport
notes: GENE_ASSOCIATION: (206358.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11390972,PMID:11959859 NOTES:NCD
reactant: MODEL1310110061#
fast: false
is described by: ECO:0000304
kinetic law: MODEL1310110061#

metaM prostge1 c
initial amount: NaN
boundary condition: false
type: Species
constant: false
notes: FORMULA: C20H33O5 CHARGE: -1 INCHI: InChI=1S/C20H34O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h12-13,15-17,19,21,23H,2-11,14H2,1H3,(H,24,25)/p-1/b13-12+/t15-,16+,17+,19+/m0/s1 EHMN_ABBREVIATION: C04741
is: CHEBI:57397
name: prostaglandin E1(1-)
is: HMDB01442
initial concentration: 1.0
is: SBO:0000247
has only substance units: false

metaM hxan e
initial concentration: 1.0
name: hypoxanthine
initial amount: NaN
boundary condition: false
has only substance units: false
type: Species
constant: false
is: SBO:0000247
notes: FORMULA: C5H4N4O CHARGE: 0 INCHI: InChI=1S/C5H4N4O/c10-5-3-4(7-1-6-3)8-2-9-5/h1-2H,(H2,6,7,8,9,10) HEPATONET_1.0_ABBREVIATION: HC00238 EHMN_ABBREVIATION: C00262
is: HMDB00157
is: CHEBI:17368

metaR ABTD
type: Reaction
is: SBO:0000176
product: MODEL1310110061#
name: L-arabinitol 4-dehydrogenase
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Pentose phosphate pathway EC Number: 1.1.1.12 Confidence Level: 2 AUTHORS: PMID:12359133,PMID:13922173,PMID:15234337 NOTES:NCD
reactant: MODEL1310110061#
kinetic law: MODEL1310110061#
fast: false
is described by: ECO:0000000

metaR r2088
fast: false
modifier: MODEL1310110061#
reactant: MODEL1310110061#
is described by: ECO:0000000
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
type: Reaction
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
reversible: true
kinetic law: MODEL1310110061#
is: SBO:0000185
product: MODEL1310110061#

metaM itp c
is: SBO:0000247
notes: FORMULA: C10H11N4O14P3 CHARGE: -4 INCHI: InChI=1S/C10H15N4O14P3/c15-6-4(1-25-30(21,22)28-31(23,24)27-29(18,19)20)26-10(7(6)16)14-3-13-5-8(14)11-2-12-9(5)17/h2-4,6-7,10,15-16H,1H2,(H,21,22)(H,23,24)(H,11,12,17)(H2,18,19,20)/p-3/t4-,6-,7-,10-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00084 EHMN_ABBREVIATION: C00081
name: ITP(3-)
constant: false
has only substance units: false
initial concentration: 1.0
is: CHEBI:57614
type: Species
initial amount: NaN
is: HMDB00189
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110061#_d1f48f8b_219c_43f8_89c0_5b210a2b3f1a
initial concentration: NaN
has only substance units: false
is: O00754
initial amount: NaN
is encoded by: hsa:4125
is: SBO:0000252
type: Species
name: MAN2B1
constant: false
boundary condition: true

metaR r0575
name: Presqualene diphosphate:farnesyl-diphosphate farnesyltransferase Biosynthesis of steroids EC:2.5.1.21
is: SBO:0000176
fast: false
kinetic law: MODEL1310110061#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (AA021081.1) or (AI440329.1) or (R06874.1) or (83549.1) or (7371.1) or (54963.1) SUBSYSTEM: Cholesterol metabolism EC Number: 2.5.1.21 Confidence Level: 0 AUTHORS: PMID:10449533,PMID:1527001,PMID:7864626,PMID:8509416 NOTES:
type: Reaction
reactant: MODEL1310110061#
is version of: http://identifiers.org/ec-code/2.7.1.48
product: MODEL1310110061#
modifier: MODEL1310110061#
reversible: true

metaR RE3017R
kinetic law: MODEL1310110061#
notes: GENE_ASSOCIATION: SUBSYSTEM: Eicosanoid metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:11368003,PMID:9799565,PMID:9862787 NOTES:
type: Reaction
reactant: MODEL1310110061#
is: SBO:0000176
reversible: true
name: RE3017
product: MODEL1310110061#
fast: false
is described by: ECO:0000000

metaR RNDR2
type: Reaction
product: MODEL1310110061#
kinetic law: MODEL1310110061#
is version of: http://identifiers.org/ec-code/1.17.4.1
modifier: MODEL1310110061#
notes: GENE_ASSOCIATION: (6240.1 and 6241.1) SUBSYSTEM: Nucleotide interconversion EC Number: 1.7.14.1 Confidence Level: 2 AUTHORS: PMID:14729598 NOTES:
reactant: MODEL1310110061#
fast: false
name: ribonucleoside-diphosphate reductase (GDP)
reversible: false
is: SBO:0000176
is described by: ECO:0000254

metaR r0688
product: MODEL1310110061#
kinetic law: MODEL1310110061#
notes: GENE_ASSOCIATION: (AA081045.1) or (AI620219.1) or (219.1) or (217.1) or (224.1) or (501.1) or (223.1) or (AU149534.1) or (T83654.1) SUBSYSTEM: Bile acid synthesis EC Number: 1.2.1.3 Confidence Level: 0 AUTHORS: PMID:11182138,PMID:8155713,PMID:9538213 NOTES:
reactant: MODEL1310110061#
is described by: ECO:0000000
modifier: MODEL1310110061#
fast: false
type: Reaction
is version of: http://identifiers.org/ec-code/1.2.1.3
reversible: true
is: SBO:0000176
name: 3alpha,7alpha-Dihydroxy-5beta-cholestan-26-al:NAD+ oxidoreductase Bile acid biosynthesis EC:1.2.1.3

metaM 1p3h5c m
is: CHEBI:6151
type: Species
initial amount: NaN
name: L-1-Pyrroline-3-hydroxy-5-carboxylate
is: SBO:0000247
is: HMDB01369
has only substance units: false
initial concentration: 1.0
constant: false
boundary condition: false
notes: FORMULA: C5H6NO3 CHARGE: -1 INCHI: InChI=1S/C5H7NO3/c7-3-1-4(5(8)9)6-2-3/h2-4,7H,1H2,(H,8,9)/t3-,4+/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01261 EHMN_ABBREVIATION: C04281

http://identifiers.org/biomodels.db/MODEL1310110061#_90a467fc_8b66_4925_bb9c_c50bf7d46f26
is encoded by: hsa:6391
has only substance units: false
constant: false
boundary condition: true
initial concentration: NaN
type: Species
name: SDHC
is: Q99643
is: SBO:0000252
initial amount: NaN

metaR ARGLYSex
product: MODEL1310110061#
name: Arginine/Lysine exchanger (Arg in)
fast: false
modifier: MODEL1310110061#
is described by: ECO:0000269
reactant: MODEL1310110061#
notes: GENE_ASSOCIATION: (9057.1 and 6520.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14770310 NOTES:SAB see PMID 14770310
kinetic law: MODEL1310110061#
type: Reaction
is: SBO:0000185
reversible: false

metaR EX ura LPAREN e RPAREN
kinetic law: MODEL1310110061#
reactant: MODEL1310110061#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Uracil exchange
type: Reaction

metaR RE3628M
name: RE3628
reactant: MODEL1310110061#
reversible: true
is version of: http://identifiers.org/ec-code/5.3.3.8
fast: false
notes: GENE_ASSOCIATION: (1632.1) or (10455.1) or (1962.1) SUBSYSTEM: Fatty acid oxidation EC Number: 5.3.3.8 Confidence Level: 0 AUTHORS: PMID:11356164,PMID:7775433 NOTES:
is described by: ECO:0000000
type: Reaction
product: MODEL1310110061#
is: SBO:0000176
modifier: MODEL1310110061#
kinetic law: MODEL1310110061#
is version of: http://identifiers.org/ec-code/1.1.1.35

metaR PHCDm
modifier: MODEL1310110061#
name: L-1-pyrroline-3-hydroxy-5-carboxylate dehydrogenase
product: MODEL1310110061#
is: SBO:0000176
reversible: false
is version of: http://identifiers.org/ec-code/1.5.1.12
kinetic law: MODEL1310110061#
type: Reaction
is described by: ECO:0000304
fast: false
reactant: MODEL1310110061#
notes: GENE_ASSOCIATION: (8659.1) or (8659.2) SUBSYSTEM: Arginine and Proline Metabolism EC Number: 1.5.1.12 Confidence Level: 2 AUTHORS: PMID:12660328,PMID:15849464,PMID:500817 NOTES:NCD

metaR RE1709N
product: MODEL1310110061#
modifier: MODEL1310110061#
type: Reaction
is: SBO:0000176
fast: false
kinetic law: MODEL1310110061#
reversible: true
notes: GENE_ASSOCIATION: (5092.1) or (84105.1) SUBSYSTEM: Tetrahydrobiopterin metabolism EC Number: 4.2.1.96 Confidence Level: 0 AUTHORS: PMID:10727395,PMID:8921004 NOTES:
name: RE1709
is version of: http://identifiers.org/ec-code/4.2.1.96
reactant: MODEL1310110061#
is described by: ECO:0000000

metaR LNLCCPT2
reactant: MODEL1310110061#
is: SBO:0000176
is described by: ECO:0000000
modifier: MODEL1310110061#
fast: false
is version of: http://identifiers.org/ec-code/2.3.1.21
reversible: false
type: Reaction
name: carnitine transferase
product: MODEL1310110061#
notes: GENE_ASSOCIATION: (1376.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: NOTES:NJ
kinetic law: MODEL1310110061#

metaM 34hpp m
notes: FORMULA: C9H7O4 CHARGE: -1 INCHI: InChI=1S/C9H8O4/c10-7-3-1-6(2-4-7)5-8(11)9(12)13/h1-4,10H,5H2,(H,12,13)/p-1 HEPATONET_1.0_ABBREVIATION: HC00699 EHMN_ABBREVIATION: C01179
boundary condition: false
is: CHEBI:36242
initial concentration: 1.0
initial amount: NaN
has only substance units: false
constant: false
is: SBO:0000247
type: Species
name: 3-(4-hydroxyphenyl)pyruvate
is: HMDB00707

metaM HC01401 m
has only substance units: false
initial amount: NaN
is: CHEBI:27668
initial concentration: 1.0
name: (S)-3-Hydroxydodecanoyl-CoA
type: Species
constant: false
boundary condition: false
is: SBO:0000247
notes: FORMULA: C33H54N7O18P3S CHARGE: -4 INCHI: InChI=1S/C33H58N7O18P3S/c1-4-5-6-7-8-9-10-11-21(41)16-24(43)62-15-14-35-23(42)12-13-36-31(46)28(45)33(2,3)18-55-61(52,53)58-60(50,51)54-17-22-27(57-59(47,48)49)26(44)32(56-22)40-20-39-25-29(34)37-19-38-30(25)40/h19-22,26-28,32,41,44-45H,4-18H2,1-3H3,(H,35,42)(H,36,46)(H,50,51)(H,52,53)(H2,34,37,38)(H2,47,48,49)/t21-,22+,26+,27+,28-,32+/m0/s1 EHMN_ABBREVIATION: C05262

metaR DHCR243r
reactant: MODEL1310110061#
is: SBO:0000176
type: Reaction
name: 24-dehydrocholesterol reductase [Precursor]
modifier: MODEL1310110061#
reversible: false
product: MODEL1310110061#
fast: false
is described by: ECO:0000134
notes: GENE_ASSOCIATION: (1718.1) SUBSYSTEM: Cholesterol metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:17984220,PMID:19520779,PMID:19520780 NOTES:lanosterol -> cholesterol pathway FAD known to be cofactor, other details missing NJ
kinetic law: MODEL1310110061#
is version of: http://identifiers.org/ec-code/1.3.1.72

metaR r1090
kinetic law: MODEL1310110061#
reactant: MODEL1310110061#
name: TCDB:2.A.47.1.9 TCDB:2.A.29.7.2
fast: false
is described by: ECO:0000000
product: MODEL1310110061#
reversible: false
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:10049700,PMID:10574970,PMID:11389679,PMID:11557028,PMID:11564694,PMID:12824232,PMID:12930836,PMID:14574404,PMID:16288981,PMID:911815 NOTES:
is: SBO:0000185

metaM biocyt m
initial amount: NaN
is: http://identifiers.org/pubchem.compound/7886
notes: FORMULA: C16H28N4O4S CHARGE: 0 INCHI: InChI=1/C16H28N4O4S/c17-10(15(22)23)5-3-4-8-18-13(21)7-2-1-6-12-14-11(9-25-12)19-16(24)20-14/h10-12,14H,1-9,17H2,(H,18,21)(H,22,23)(H2,19,20,24)/t10-,11-,12-,14-/m0/s1 EHMN_ABBREVIATION: C05552
has only substance units: false
is: C05552
constant: false
name: Biocytin
is: HMDB03134
type: Species
boundary condition: false
initial concentration: 1.0
is: SBO:0000247

metaR r2087
product: MODEL1310110061#
is described by: ECO:0000000
is: SBO:0000185
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
kinetic law: MODEL1310110061#
type: Reaction
modifier: MODEL1310110061#
fast: false
reactant: MODEL1310110061#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
reversible: true

metaM 5adtststerone r
name: 17beta-hydroxy-5alpha-androstan-3-one
boundary condition: false
is: SBO:0000247
type: Species
is: HMDB02961
initial amount: NaN
notes: FORMULA: C19H30O2 CHARGE: 0 INCHI: InChI=1S/C19H30O2/c1-18-9-7-13(20)11-12(18)3-4-14-15-5-6-17(21)19(15,2)10-8-16(14)18/h12,14-17,21H,3-11H2,1-2H3/t12-,14-,15-,16-,17-,18-,19-/m0/s1 EHMN_ABBREVIATION: C03917
is: CHEBI:16330
has only substance units: false
constant: false
initial concentration: 1.0

metaM leuktrE4 e
type: Species
is: HMDB02200
boundary condition: false
is: SBO:0000247
notes: FORMULA: C23H36NO5S CHARGE: -1 INCHI: InChI=1S/C23H37NO5S/c1-2-3-4-5-6-7-8-9-10-11-12-13-16-21(30-18-19(24)23(28)29)20(25)15-14-17-22(26)27/h6-7,9-13,16,19-21,25H,2-5,8,14-15,17-18,24H2,1H3,(H,26,27)(H,28,29)/p-1/b7-6-,10-9-,12-11+,16-13+/t19-,20-,21+/m0/s1 EHMN_ABBREVIATION: C05952
is: CHEBI:57462
initial amount: NaN
name: leukotriene E4(1-)
constant: false
has only substance units: false
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110061#_858f7e43_8e88_42c5_99d0_6665212dec6a
type: Species
initial amount: NaN
is: SBO:0000252
initial concentration: NaN
boundary condition: true
name: _AA532636_1_m
has only substance units: false
constant: false
is encoded by: hsa:AA532636

metaR ACACtx
name: acetoacetate intracellular transport unknown mechanism
product: MODEL1310110061#
kinetic law: MODEL1310110061#
is: SBO:0000185
reactant: MODEL1310110061#
fast: false
reversible: true
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 1 AUTHORS: NOTES:unknown mechanism NJ
is described by: ECO:0000000

metaR ACHtn
type: Reaction
product: MODEL1310110061#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 1 AUTHORS: NOTES:it
name: Acetylcholin transport, nuclear trhough pores
reversible: true
is: SBO:0000185
kinetic law: MODEL1310110061#
fast: false
is described by: ECO:0000000
reactant: MODEL1310110061#

metaR FAOXC123m
kinetic law: MODEL1310110061#
product: MODEL1310110061#
reactant: MODEL1310110061#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: isomerization(C12:3)m
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110061#_43591803_f0d5_4700_a503_b40a81828cd0
is encoded by: hsa:204
initial amount: NaN
constant: false
initial concentration: NaN
has only substance units: false
type: Species
is: SBO:0000252
is: P54819
name: AK2
boundary condition: true

metaM 3mox4hpac m
has only substance units: false
initial amount: NaN
constant: false
name: (4-hydroxy-3-methoxyphenyl)acetaldehyde
type: Species
is: HMDB05175
boundary condition: false
is: CHEBI:28111
initial concentration: 1.0
notes: FORMULA: C9H10O3 CHARGE: 0 INCHI: InChI=1S/C9H10O3/c1-12-9-6-7(4-5-10)2-3-8(9)11/h2-3,5-6,11H,4H2,1H3 HEPATONET_1.0_ABBREVIATION: HC01518 EHMN_ABBREVIATION: C05581
is: SBO:0000247

metaR PNTK
reversible: false
name: pantothenate kinase
product: MODEL1310110061#
reactant: MODEL1310110061#
is: SBO:0000176
kinetic law: MODEL1310110061#
modifier: MODEL1310110061#
fast: false
is described by: ECO:0000269
type: Reaction
is version of: http://identifiers.org/ec-code/2.7.1.33
notes: GENE_ASSOCIATION: (79646.1) or (80025.2) or (53354.1) or (53354.3) or (80025.1) or (53354.2) or (80025.3) or (80025.4) or (55229.1) SUBSYSTEM: CoA synthesis EC Number: Confidence Level: 4 AUTHORS: NOTES:

http://identifiers.org/biomodels.db/MODEL1310110061#_fc5c6cf6_aa59_4c8b_9920_216e0606f0fe
type: Species
is: SBO:0000252
is encoded by: hsa:5289
constant: false
name: PIK3C3
initial concentration: NaN
is: Q8NEB9
boundary condition: true
initial amount: NaN
has only substance units: false

metaR RNDR1
reversible: false
reactant: MODEL1310110061#
fast: false
product: MODEL1310110061#
is version of: http://identifiers.org/ec-code/1.17.4.1
name: ribonucleoside-diphosphate reductase (ADP)
kinetic law: MODEL1310110061#
is: SBO:0000176
notes: GENE_ASSOCIATION: (6240.1 and 6241.1) SUBSYSTEM: Nucleotide interconversion EC Number: 1.7.14.1 Confidence Level: 2 AUTHORS: PMID:14729598 NOTES:
is described by: ECO:0000254
modifier: MODEL1310110061#
type: Reaction

metaM akg c
is: C00026
initial amount: NaN
notes: FORMULA: C5H4O5 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00035 EHMN_ABBREVIATION: C00026
initial concentration: 1.0
is: SBO:0000247
type: Species
is: HMDB00208
is: CHEBI:16810
has only substance units: false
name: 2-Oxoglutarate
constant: false
boundary condition: false

metaR EX ile L LPAREN e RPAREN
kinetic law: MODEL1310110061#
reactant: MODEL1310110061#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: L-Isoleucine exchange
type: Reaction

metaR P5CR
is described by: ECO:0000134
name: pyrroline-5-carboxylate reductase
notes: GENE_ASSOCIATION: SUBSYSTEM: Arginine and Proline Metabolism EC Number: 1.5.1.2 Confidence Level: 4 AUTHORS: PMID: 11458019, Sareen S. Gropper, jack L. Smith, James L. Groff (2009) Wadaworth cengage learning, Advanced nutrition and human metabolism, 5th edition, page 194-196 NOTES:
reactant: MODEL1310110061#
is: SBO:0000176
fast: false
product: MODEL1310110061#
kinetic law: MODEL1310110061#
type: Reaction
reversible: false

metaR FACOAL2042
reactant: MODEL1310110061#
notes: GENE_ASSOCIATION: (2180.1) SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 4 AUTHORS: PMID:15292367 NOTES:rev version so additional rxn doesn't need to be added to "unload" AA alternate to arachidonic acid (n-3 rather than n-6) NJ
is version of: http://identifiers.org/ec-code/6.2.1.3
modifier: MODEL1310110061#
name: fatty-acid--CoA ligase
is: SBO:0000176
reversible: true
product: MODEL1310110061#
fast: false
type: Reaction
kinetic law: MODEL1310110061#
is described by: ECO:0000000

metaM amp e
initial amount: NaN
initial concentration: 1.0
has only substance units: false
is: CHEBI:456215
notes: FORMULA: C10H12N5O7P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00030 EHMN_ABBREVIATION: C00020
is: SBO:0000247
type: Species
constant: false
name: AMP
is: C00020
is: HMDB00045
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110061#_19cce646_3ffe_4473_a3ea_e0d3cce24d15
is encoded by: hsa:8704
type: Species
name: B4GALT2
initial amount: NaN
initial concentration: NaN
constant: false
boundary condition: true
is: SBO:0000252
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110061#_51fab77b_75fd_4cb1_848f_63f6a3dafe9d
constant: false
is: SBO:0000252
initial concentration: NaN
boundary condition: true
is: P00325
is encoded by: hsa:125
has only substance units: false
name: ADH1B
type: Species
initial amount: NaN

metaM hdcoa c
has only substance units: false
boundary condition: false
type: Species
constant: false
initial amount: NaN
is: SBO:0000247
is: HMDB06532
initial concentration: 1.0
name: Hexadecenoyl-CoA (n-C16:1CoA)
notes: FORMULA: C37H60N7O17P3S CHARGE: -4

metaM hxan c
is: CHEBI:17368
initial concentration: 1.0
is: HMDB00157
is: C00262
has only substance units: false
boundary condition: false
initial amount: NaN
type: Species
notes: FORMULA: C5H4N4O CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00238 EHMN_ABBREVIATION: C00262
name: Hypoxanthine
constant: false
is: SBO:0000247

metaR r0339
fast: false
is version of: http://identifiers.org/ec-code/3.1.2.2
kinetic law: MODEL1310110061#
is version of: http://identifiers.org/ec-code/3.1.2.22
modifier: MODEL1310110061#
reactant: MODEL1310110061#
name: ATP:(R)-glycerate 3-phosphotransferase Glycine, serine and threonine metabolism EC:2.7.1.31
is described by: ECO:0000000
type: Reaction
reversible: false
notes: GENE_ASSOCIATION: (10965.1) or (122970.1) or (11332.1) or (570.1) or (80864.1) or (83715.1) or (5538.1) or (9374.1) or (R33828.1) SUBSYSTEM: Unassigned EC Number: 2.7.1.31 Confidence Level: 0 AUTHORS: PMID:16753811,PMID:216417,PMID:2537226,PMID:6252205 NOTES:
product: MODEL1310110061#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.3.1.65

metaR r0686
fast: false
notes: GENE_ASSOCIATION: (AI222095.1) or (AI697028.1) or (D87002.1) or (2678.1) or (728441.1) or (2687.1) or (2686.1) or (728226.1) or (NM_013421.1) SUBSYSTEM: Arginine and Proline Metabolism EC Number: 1.5.1.12 Confidence Level: 0 AUTHORS: PMID:1286669,PMID:2211729 NOTES:
is: SBO:0000176
reversible: true
name: L-1-Pyrroline-3-hydroxy-5-carboxylate:NADP+ oxidoreductase Arginine and proline metabolism EC:1.5.1.12
product: MODEL1310110061#
is described by: ECO:0000000
reactant: MODEL1310110061#
is version of: http://identifiers.org/ec-code/2.3.2.2
type: Reaction
kinetic law: MODEL1310110061#
modifier: MODEL1310110061#

metaM aicar c
notes: FORMULA: C9H13N4O8P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC01334 EHMN_ABBREVIATION: C04677
initial amount: NaN
is: SBO:0000247
constant: false
is: CHEBI:58475
is: C04677
name: 5-Amino-1-(5-Phospho-D-ribosyl)imidazole-4-carboxamide
is: HMDB01517
has only substance units: false
initial concentration: 1.0
type: Species
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110061#_aeb45ebb_a00f_4bae_b7a8_8ea204fffa7c
is: Q96I99
initial concentration: NaN
initial amount: NaN
constant: false
has only substance units: false
name: SUCLG2
is encoded by: hsa:8801
boundary condition: true
is: SBO:0000252
type: Species

http://identifiers.org/biomodels.db/MODEL1310110061#_ea95e7ad_67d8_4177_b81e_822866418837
has only substance units: false
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:587
is: O15382
name: BCAT2
initial amount: NaN
boundary condition: true
constant: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110061#_12fadeb5_7de2_49d3_ad6a_38467622a244
is: Q02318
has only substance units: false
is encoded by: hsa:1593
boundary condition: true
is: SBO:0000252
constant: false
initial amount: NaN
type: Species
initial concentration: NaN
name: CYP27A1

metaR EX tettet6 LPAREN e RPAREN
kinetic law: MODEL1310110061#
reactant: MODEL1310110061#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: tetracosatetraenoic acid n-6 exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110061#_ef1cf9fb_74db_4341_b2f1_c9340b6de99a
is: Q8N370
initial concentration: NaN
is: SBO:0000252
name: SLC43A2
has only substance units: false
boundary condition: true
constant: false
is encoded by: hsa:124935
initial amount: NaN
type: Species

http://identifiers.org/biomodels.db/MODEL1310110061#_8ad03e7c_c2c2_4f12_8b96_433a64c0c4af
initial amount: NaN
is encoded by: hsa:2180
is: P33121
has only substance units: false
boundary condition: true
type: Species
initial concentration: NaN
is: SBO:0000252
name: ACSL1
constant: false

metaM gmp c
type: Species
constant: false
notes: FORMULA: C10H12N5O8P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00141 EHMN_ABBREVIATION: C00144
name: GMP
initial concentration: 1.0
is: HMDB01397
boundary condition: false
is: CHEBI:58115
has only substance units: false
is: C00144
is: SBO:0000247
initial amount: NaN

metaM HC01405 m
initial concentration: 1.0
is: CHEBI:28632
notes: FORMULA: C29H46N7O18P3S CHARGE: -4 INCHI: InChI=1S/C29H50N7O18P3S/c1-4-5-6-7-17(37)12-20(39)58-11-10-31-19(38)8-9-32-27(42)24(41)29(2,3)14-51-57(48,49)54-56(46,47)50-13-18-23(53-55(43,44)45)22(40)28(52-18)36-16-35-21-25(30)33-15-34-26(21)36/h15-18,22-24,28,37,40-41H,4-14H2,1-3H3,(H,31,38)(H,32,42)(H,46,47)(H,48,49)(H2,30,33,34)(H2,43,44,45)/t17-,18+,22+,23+,24-,28+/m0/s1 EHMN_ABBREVIATION: C05266
constant: false
name: (S)-Hydroxyoctanoyl-CoA
has only substance units: false
type: Species
boundary condition: false
is: SBO:0000247
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110061#_9d179626_4026_4b8c_9864_cd4b17cfc885
constant: false
name: NDUFA5
initial amount: NaN
boundary condition: true
is: Q16718
is encoded by: hsa:4698
initial concentration: NaN
type: Species
has only substance units: false
is: SBO:0000252

metaR r0483
reactant: MODEL1310110061#
reversible: true
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Pyrimidine catabolism EC Number: 2.6.1.22 Confidence Level: 0 AUTHORS: PMID:5773299 NOTES:
is: SBO:0000176
fast: false
product: MODEL1310110061#
kinetic law: MODEL1310110061#
name: (R)-3-Amino-2-methylpropanoate:2-oxoglutarate aminotransferase EC:2.6.1.22
type: Reaction

metaR r2089
reactant: MODEL1310110061#
type: Reaction
fast: false
reversible: true
modifier: MODEL1310110061#
kinetic law: MODEL1310110061#
product: MODEL1310110061#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
is: SBO:0000185
is described by: ECO:0000000

metaR EX bilglcur LPAREN e RPAREN
kinetic law: MODEL1310110061#
reactant: MODEL1310110061#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for blirubin mono-glucuronide
type: Reaction

metaM prostgf2 e
initial amount: NaN
constant: false
is: SBO:0000247
is: CHEBI:57404
notes: FORMULA: C20H33O5 CHARGE: -1 INCHI: InChI=1S/C20H34O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h4,7,12-13,15-19,21-23H,2-3,5-6,8-11,14H2,1H3,(H,24,25)/p-1/b7-4-,13-12+/t15-,16+,17+,18-,19+/m0/s1 EHMN_ABBREVIATION: C00639
name: prostaglandin F2alpha(1-)
type: Species
has only substance units: false
initial concentration: 1.0
is: HMDB01139
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110061#_258dff9f_a900_4c96_8dc4_c390f8d515ab
initial amount: NaN
has only substance units: false
name: TREH
is: SBO:0000252
type: Species
is encoded by: hsa:11181
initial concentration: NaN
boundary condition: true
is: O43280
constant: false

metaR SIAT4Bg
notes: GENE_ASSOCIATION: (6483.1) SUBSYSTEM: Sphingolipid metabolism EC Number: 2.4.99.4 Confidence Level: 4 AUTHORS: PMID:9266697 NOTES:NJ
modifier: MODEL1310110061#
reversible: false
reactant: MODEL1310110061#
is version of: http://identifiers.org/ec-code/2.4.99.4
product: MODEL1310110061#
fast: false
type: Reaction
kinetic law: MODEL1310110061#
is described by: ECO:0000269
is: SBO:0000176
name: Beta-galactoside alpha-2,3-sialyltransferase, Golgi apparatus

http://identifiers.org/biomodels.db/MODEL1310110061#_7bada31e_3fb6_4de0_9877_9f597de01bda
is: SBO:0000252
boundary condition: true
initial amount: NaN
constant: false
type: Species
initial concentration: NaN
name: CHKB
is: A0PJM6
is encoded by: hsa:1120
has only substance units: false

metaM leuktrE4 c
is: SBO:0000247
has only substance units: false
notes: FORMULA: C23H36NO5S CHARGE: -1 INCHI: InChI=1S/C23H37NO5S/c1-2-3-4-5-6-7-8-9-10-11-12-13-16-21(30-18-19(24)23(28)29)20(25)15-14-17-22(26)27/h6-7,9-13,16,19-21,25H,2-5,8,14-15,17-18,24H2,1H3,(H,26,27)(H,28,29)/p-1/b7-6-,10-9-,12-11+,16-13+/t19-,20-,21+/m0/s1 EHMN_ABBREVIATION: C05952
is: HMDB02200
constant: false
name: leukotriene E4(1-)
boundary condition: false
is: CHEBI:57462
type: Species
initial amount: NaN
initial concentration: 1.0

metaM akg e
is: SBO:0000247
is: HMDB00208
type: Species
initial concentration: 1.0
is: CHEBI:16810
name: 2-oxoglutarate(2-)
has only substance units: false
constant: false
notes: FORMULA: C5H4O5 CHARGE: -2 INCHI: InChI=1S/C5H6O5/c6-3(5(9)10)1-2-4(7)8/h1-2H2,(H,7,8)(H,9,10)/p-2 HEPATONET_1.0_ABBREVIATION: HC00035 EHMN_ABBREVIATION: C00026
initial amount: NaN
boundary condition: false

metaR O2ter
name: O2 transport, endoplasmic reticulum
is described by: ECO:0000000
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD
product: MODEL1310110061#
fast: false
type: Reaction
reactant: MODEL1310110061#
kinetic law: MODEL1310110061#
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110061#_5a12e9fd_7c59_46f1_9646_469caf1161a9
is encoded by: hsa:1103
is: SBO:0000252
type: Species
boundary condition: true
constant: false
initial amount: NaN
initial concentration: NaN
name: CHAT
is: D3DX95
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110061#_a4eca30e_4262_4fa7_b380_b026e7cc24c4
is encoded by: hsa:6523
has only substance units: false
boundary condition: true
type: Species
initial concentration: NaN
constant: false
name: SLC5A1
initial amount: NaN
is: SBO:0000252
is: P13866

metaM hmgcoa x
initial concentration: 1.0
type: Species
constant: false
boundary condition: false
notes: FORMULA: C27H39N7O20P3S CHARGE: -5 INCHI: InChI=1S/C27H44N7O20P3S/c1-26(2,21(40)24(41)30-5-4-15(35)29-6-7-58-17(38)9-27(3,42)8-16(36)37)11-51-57(48,49)54-56(46,47)50-10-14-20(53-55(43,44)45)19(39)25(52-14)34-13-33-18-22(28)31-12-32-23(18)34/h12-14,19-21,25,39-40,42H,4-11H2,1-3H3,(H,29,35)(H,30,41)(H,36,37)(H,46,47)(H,48,49)(H2,28,31,32)(H2,43,44,45)/t14-,19-,20-,21+,25-,27+/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00302 EHMN_ABBREVIATION: C00356
is: HMDB01375
has only substance units: false
is: SBO:0000247
is: CHEBI:15467
name: Hydroxymethylglutaryl-CoA
initial amount: NaN

metaR r0579
product: MODEL1310110061#
kinetic law: MODEL1310110061#
is version of: http://identifiers.org/ec-code/1.13.11.19
name: ATP:pantothenate 4-phosphotransferase Pantothenate and CoA biosynthesis EC:2.7.1.33
reactant: MODEL1310110061#
is described by: ECO:0000000
reversible: true
type: Reaction
modifier: MODEL1310110061#
fast: false
notes: GENE_ASSOCIATION: (84890.1) or (AV713053.1) SUBSYSTEM: CoA synthesis EC Number: 2.7.1.33 Confidence Level: 0 AUTHORS: PMID:13163064,PMID:15105273,PMID:15659606 NOTES:
is: SBO:0000176

metaM m2mn l
notes: FORMULA: C26H45NO21 CHARGE: 0 INCHI: InChI=1/C26H45NO21/c1-6(32)27-11-15(36)20(10(5-31)42-23(11)41)46-25-18(39)22(14(35)8(3-29)44-25)48-26-19(40)21(13(34)9(4-30)45-26)47-24-17(38)16(37)12(33)7(2-28)43-24/h7-26,28-31,33-41H,2-5H2,1H3,(H,27,32)/t7-,8-,9-,10+,11+,12-,13-,14-,15+,16+,17+,18+,19+,20+,21+,22+,23+,24-,25+,26+/m0/s1
boundary condition: false
initial amount: NaN
initial concentration: 1.0
is: SBO:0000247
name: (alpha-D-mannosyl)2-beta-D-mannosyl-N-acetylglucosamine
constant: false
is: HMDB06537
has only substance units: false
type: Species

metaR r2197
reversible: true
notes: GENE_ASSOCIATION: (6566.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
kinetic law: MODEL1310110061#
type: Reaction
is: SBO:0000185
modifier: MODEL1310110061#
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.14
reactant: MODEL1310110061#
fast: false
product: MODEL1310110061#
is described by: ECO:0000000

metaM hexccoa x
initial amount: NaN
notes: FORMULA: C47H82N7O17P3S CHARGE: -4 INCHI: InChI=1/C47H86N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-24-25-26-27-38(56)75-31-30-49-37(55)28-29-50-45(59)42(58)47(2,3)33-68-74(65,66)71-73(63,64)67-32-36-41(70-72(60,61)62)40(57)46(69-36)54-35-53-39-43(48)51-34-52-44(39)54/h34-36,40-42,46,57-58H,4-33H2,1-3H3,(H,49,55)(H,50,59)(H,63,64)(H,65,66)(H2,48,51,52)(H2,60,61,62)/p-4/t36-,40-,41-,42+,46-/m1/s1
boundary condition: false
is: SBO:0000247
is: HMDB06459
initial concentration: 1.0
name: Hexacosanoyl-CoA (n-C26:0CoA)
constant: false
has only substance units: false
type: Species

metaR EX ser L LPAREN e RPAREN
kinetic law: MODEL1310110061#
reactant: MODEL1310110061#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for L-serine
type: Reaction

metaR r2106
type: Reaction
modifier: MODEL1310110061#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
product: MODEL1310110061#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
reactant: MODEL1310110061#
kinetic law: MODEL1310110061#
fast: false
reversible: true
is: SBO:0000185
is described by: ECO:0000000

metaM apoC Lys btn m
initial concentration: 1.0
notes: FORMULA: C16H27N4O3SX CHARGE: 0
constant: false
is: C05552
is: HMDB03134
boundary condition: false
type: Species
has only substance units: false
is: SBO:0000247
initial amount: NaN
name: Holocarboxylase (biotin covalent bound to Lys residue of apoC)
is: http://identifiers.org/pubchem.compound/7886

metaM lac L x
name: (S)-lactate
notes: FORMULA: C3H5O3 CHARGE: -1 INCHI: InChI=1S/C3H6O3/c1-2(4)3(5)6/h2,4H,1H3,(H,5,6)/p-1/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00177
is: HMDB00190
is: SBO:0000247
boundary condition: false
initial concentration: 1.0
has only substance units: false
type: Species
constant: false
initial amount: NaN
is: CHEBI:16651

http://identifiers.org/biomodels.db/MODEL1310110061#_90d9c9d8_5c63_4b8a_83bf_fa8562c178b6
is: SBO:0000252
is encoded by: hsa:X63359
type: Species
initial concentration: NaN
constant: false
initial amount: NaN
name: _X63359_1_c
has only substance units: false
boundary condition: true

metaR MANt1r
modifier: MODEL1310110061#
notes: GENE_ASSOCIATION: (6513.1) or (6515.1) or (6514.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:11882499,PMID:12135767,PMID:12750891,PMID:1701966,PMID:2182619,PMID:3103217,PMID:3399500,PMID:3839598,PMID:7926364,PMID:9770484 NOTES:NCD
product: MODEL1310110061#
reversible: true
is described by: ECO:0000269
reactant: MODEL1310110061#
kinetic law: MODEL1310110061#
type: Reaction
is: SBO:0000185
name: mannose transport (uniport)
fast: false

metaR r1575
kinetic law: MODEL1310110061#
reactant: MODEL1310110061#
product: MODEL1310110061#
type: Reaction
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is: SBO:0000185
fast: false
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is described by: ECO:0000000

metaR DHEAtr
fast: false
product: MODEL1310110061#
kinetic law: MODEL1310110061#
reactant: MODEL1310110061#
is: SBO:0000185
is described by: ECO:0000269
name: Dehydroepiandrosterone transport
type: Reaction
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: 2.8.2.2 Confidence Level: 1 AUTHORS: PMID:11535246,PMID:1588921 NOTES:

metaR PI34P5K
product: MODEL1310110061#
modifier: MODEL1310110061#
reactant: MODEL1310110061#
kinetic law: MODEL1310110061#
fast: false
type: Reaction
is: SBO:0000176
name: phosphatidylinositol 3,4-bisphosphate 5-kinase
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (8394.1) or (23396.1) or (8395.1) SUBSYSTEM: Inositol phosphate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:10358929,PMID:1850246,PMID:1851250,PMID:2174884,PMID:8042983 NOTES:NCD
reversible: false
is version of: http://identifiers.org/ec-code/2.7.1.68

metaM HC00900 c
is: SBO:0000247
is: CHEBI:30860
type: Species
initial concentration: 1.0
has only substance units: false
notes: FORMULA: C4H4O4 CHARGE: -2 INCHI: InChI=1S/C4H6O4/c1-2(3(5)6)4(7)8/h2H,1H3,(H,5,6)(H,7,8) EHMN_ABBREVIATION: C02170
name: Methylmalonate
initial amount: NaN
boundary condition: false
constant: false

metaR r0578
name: ATP:pantothenate 4-phosphotransferase Pantothenate and CoA biosynthesis EC:2.7.1.33
is: SBO:0000176
product: MODEL1310110061#
kinetic law: MODEL1310110061#
modifier: MODEL1310110061#
is version of: http://identifiers.org/ec-code/4.1.2.27
fast: false
reactant: MODEL1310110061#
is described by: ECO:0000000
reversible: true
type: Reaction
notes: GENE_ASSOCIATION: (8879.1) SUBSYSTEM: CoA synthesis EC Number: 2.7.1.33 Confidence Level: 0 AUTHORS: PMID:13163064,PMID:15105273,PMID:15659606 NOTES:

metaR GLCAASE9ly
fast: false
reversible: false
kinetic law: MODEL1310110061#
product: MODEL1310110061#
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (2990.1) SUBSYSTEM: Hyaluronan metabolism EC Number: 3.2.1.31 Confidence Level: 4 AUTHORS: PMID:3468507,PMID:3924735,PMID:3987656 NOTES:NCD
is version of: http://identifiers.org/ec-code/3.2.1.31
type: Reaction
is: SBO:0000176
name: beta-glucuronidase, lysosomal
reactant: MODEL1310110061#
modifier: MODEL1310110061#

metaM pa hs n
initial concentration: 1.0
type: Species
constant: false
has only substance units: false
is: CHEBI:57739
name: phosphatidate(2-)
initial amount: NaN
notes: FORMULA: C3H5O4PFULLRCO2FULLR2CO2 CHARGE: -2 EHMN_ABBREVIATION: C00416
boundary condition: false
is: SBO:0000247

metaR BACCL
is: SBO:0000176
product: MODEL1310110061#
is version of: http://identifiers.org/ec-code/6.3.4.10
fast: false
kinetic law: MODEL1310110061#
name: biotin-[acetyl-CoA-carboxylase] ligase
modifier: MODEL1310110061#
notes: GENE_ASSOCIATION: (3141.1) SUBSYSTEM: Biotin metabolism EC Number: 6.3.4.15 Confidence Level: 4 AUTHORS: PMID:12459313,PMID:7842009 NOTES:IT
type: Reaction
reversible: false
reactant: MODEL1310110061#
is described by: ECO:0000269

metaM ascb L c
is: HMDB00044
initial amount: NaN
type: Species
constant: false
boundary condition: false
is: SBO:0000247
is: CHEBI:38290
notes: FORMULA: C6H7O6 CHARGE: -1 INCHI: InChI=1S/C6H8O6/c7-1-2(8)5-3(9)4(10)6(11)12-5/h2,5,7-10H,1H2/p-1/t2-,5+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00074
has only substance units: false
initial concentration: 1.0
name: L-ascorbate

metaR LSTO1r
kinetic law: MODEL1310110061#
is: SBO:0000176
name: Lathosterol oxidase
reactant: MODEL1310110061#
is version of: http://identifiers.org/ec-code/1.14.21.6
modifier: MODEL1310110061#
product: MODEL1310110061#
notes: GENE_ASSOCIATION: (6309.1) SUBSYSTEM: Cholesterol metabolism EC Number: 1.3.3.2 Confidence Level: 4 AUTHORS: PMID:10344195 NOTES:lanosterol -> cholesterol pathway NJ
is described by: ECO:0000269
reversible: false
fast: false
type: Reaction

metaR ABUTt2r
notes: GENE_ASSOCIATION: (206358.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11390972,PMID:11959859 NOTES:SAB r
name: 4-aminobutyrate reversible transport in via proton symport
is: SBO:0000185
type: Reaction
fast: false
reversible: true
is described by: ECO:0000304
modifier: MODEL1310110061#
kinetic law: MODEL1310110061#
reactant: MODEL1310110061#
product: MODEL1310110061#

metaR AKGMALtm
reactant: MODEL1310110061#
is described by: ECO:0000269
kinetic law: MODEL1310110061#
modifier: MODEL1310110061#
product: MODEL1310110061#
fast: false
reversible: true
type: Reaction
notes: GENE_ASSOCIATION: (8402.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172 NOTES:TV
name: alpha-ketoglutarate/malate transporter
is: SBO:0000185

metaR r0683
modifier: MODEL1310110061#
kinetic law: MODEL1310110061#
notes: GENE_ASSOCIATION: (30.1) or (10449.1) or (3032.1) or (4645.1) SUBSYSTEM: Unassigned EC Number: 1.3.99.3 Confidence Level: 0 AUTHORS: PMID:10502673,PMID:3597357,PMID:4062874 NOTES:
reversible: false
is described by: ECO:0000000
type: Reaction
reactant: MODEL1310110061#
name: Propanoyl-CoA:(acceptor) 2,3-oxidoreductase beta-Alanine metabolism EC:1.3.3.6 EC:1.3.99.3
is version of: http://identifiers.org/ec-code/2.3.1.16
product: MODEL1310110061#
is: SBO:0000176
fast: false

metaR r2196
product: MODEL1310110061#
is described by: ECO:0000000
is: SBO:0000185
modifier: MODEL1310110061#
reversible: true
fast: false
notes: GENE_ASSOCIATION: (6566.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
kinetic law: MODEL1310110061#
type: Reaction
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.14
reactant: MODEL1310110061#

metaM Rtotalcoa c
is: SBO:0000247
notes: FORMULA: CO2FULLRC21H31N7O15P3S CHARGE: -4
name: R total Coenzyme A
is: CHEBI:16189
initial amount: NaN
is: HMDB01448
constant: false
type: Species
has only substance units: false
boundary condition: false
initial concentration: 1.0

metaR q10tm
reactant: MODEL1310110061#
type: Reaction
kinetic law: MODEL1310110061#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: NOTES:
is described by: ECO:0000134
reversible: true
product: MODEL1310110061#
name: transport of ubiquinone into mitochondria
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110061#_37c6a50a_3f2f_4d6c_b2d5_2112929bebe8
boundary condition: true
initial concentration: NaN
type: Species
constant: false
is encoded by: hsa:10449
has only substance units: false
initial amount: NaN
name: ACAA2
is: P42765
is: SBO:0000252

metaR EX udpg LPAREN e RPAREN
kinetic law: MODEL1310110061#
reactant: MODEL1310110061#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of [(2R,3S,4R,5R)-5-(2,4-dioxo-1,2,3,4-tetrahydropyrimidin-1-yl)-3,4-dihydroxyoxolan-2-yl]methyl {[(3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl phosphonato]oxy}phosphonate
type: Reaction

metaR FAS160COA
fast: false
reversible: false
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.3.1.85
modifier: MODEL1310110061#
name: fatty-acyl-CoA synthase (n-C16:0CoA)
is described by: ECO:0000269
kinetic law: MODEL1310110061#
type: Reaction
product: MODEL1310110061#
reactant: MODEL1310110061#
notes: GENE_ASSOCIATION: (2194.1) SUBSYSTEM: Fatty acid synthesis EC Number: 2.3.1.86 Confidence Level: 4 AUTHORS: PMID:11756679,PMID:15507492,PMID:2669958 NOTES:NCD

metaR APOC LYS BTNPm
notes: GENE_ASSOCIATION: SUBSYSTEM: Biotin metabolism EC Number: Confidence Level: 2 AUTHORS: NOTES:
is described by: ECO:0000000
product: MODEL1310110061#
reversible: false
name: proteolysis of apoC-Lys-btn, mitochondrial
fast: false
kinetic law: MODEL1310110061#
reactant: MODEL1310110061#
is: SBO:0000176
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110061#_01854c1a_0f11_4178_aa92_cbab91336225
has only substance units: false
constant: false
initial amount: NaN
is: SBO:0000252
initial concentration: NaN
name: _22305_1_c
boundary condition: true
type: Species
is encoded by: hsa:22305

http://identifiers.org/biomodels.db/MODEL1310110061#_00a97fbe_aa86_4e9e_986d_119e51c0b239
name: ACSS2
is: SBO:0000252
is: Q5QPH3
initial concentration: NaN
type: Species
has only substance units: false
initial amount: NaN
boundary condition: true
is encoded by: hsa:55902
constant: false

http://identifiers.org/biomodels.db/MODEL1310110061#_9187fb80_94ea_4ebb_9acf_d97027bfc66b
initial concentration: NaN
initial amount: NaN
constant: false
is encoded by: hsa:79646
type: Species
is: SBO:0000252
name: PANK3
boundary condition: true
has only substance units: false
is: Q9H999

metaR 3SALATAim
kinetic law: MODEL1310110061#
reversible: false
is version of: http://identifiers.org/ec-code/2.6.1.1
type: Reaction
fast: false
product: MODEL1310110061#
modifier: MODEL1310110061#
notes: GENE_ASSOCIATION: (2806.1) SUBSYSTEM: Methionine and cysteine metabolism EC Number: 2.6.1.1 Confidence Level: 2 AUTHORS: PMID:3346220 NOTES:MM. activity measured in rat, 3-sulfinoalanine is substrate found in human brain
name: 3-sulfino-alanine transaminase (irreversible), mitochondrial
is described by: ECO:0000304
is: SBO:0000176
reactant: MODEL1310110061#

metaR r1574
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reactant: MODEL1310110061#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
product: MODEL1310110061#
type: Reaction
fast: false
kinetic law: MODEL1310110061#
is described by: ECO:0000000
reversible: true
is: SBO:0000185

metaR r2107
product: MODEL1310110061#
is described by: ECO:0000000
type: Reaction
reactant: MODEL1310110061#
is: SBO:0000185
modifier: MODEL1310110061#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
reversible: true
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
kinetic law: MODEL1310110061#
fast: false

metaM etha c
name: etha[c]
initial amount: NaN
notes: FORMULA: C2H8NO CHARGE: 1 INCHI: InChI=1S/C2H7NO/c3-1-2-4/h4H,1-3H2/p+1 HEPATONET_1.0_ABBREVIATION: HC00180 EHMN_ABBREVIATION: C00189
constant: false
boundary condition: false
is: CHEBI:57603
initial concentration: 1.0
is: SBO:0000247
type: Species
has only substance units: false
is: HMDB00149

metaR ILEtec
kinetic law: MODEL1310110061#
modifier: MODEL1310110061#
product: MODEL1310110061#
is: SBO:0000185
type: Reaction
reversible: true
is described by: ECO:0000269
name: L-isoleucine transport via diffusion (extracellular to cytosol)
fast: false
notes: GENE_ASSOCIATION: (8501.1) or (124935.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12930836,PMID:14624363,PMID:15659399 NOTES:SAB
reactant: MODEL1310110061#

http://identifiers.org/biomodels.db/MODEL1310110061#_ffbc9cc8_2721_4795_b508_01b550c720c2
is: SBO:0000252
initial concentration: NaN
constant: false
is: P36269
name: GGT5
is encoded by: hsa:2687
initial amount: NaN
boundary condition: true
type: Species
has only substance units: false

metaR UAG4E
reactant: MODEL1310110061#
type: Reaction
fast: false
reversible: true
name: UDP-N-acetylglucosamine 4-epimerase
modifier: MODEL1310110061#
product: MODEL1310110061#
is described by: ECO:0000304
notes: GENE_ASSOCIATION: (2582.1) or (2582.2) SUBSYSTEM: Aminosugar metabolism EC Number: 5.1.3.7 Confidence Level: 2 AUTHORS: NOTES:NCD
kinetic law: MODEL1310110061#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/5.1.3.2

metaR r0603
is version of: http://identifiers.org/ec-code/2.3.1.12
notes: GENE_ASSOCIATION: (AW299740.1) or (1737.1) or (J03866.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 1.3.99.12 Confidence Level: 0 AUTHORS: PMID:6401712 NOTES:
modifier: MODEL1310110061#
reactant: MODEL1310110061#
is: SBO:0000176
product: MODEL1310110061#
reversible: true
is described by: ECO:0000000
fast: false
name: (S)-2-methylbutanoyl-CoA:acceptor 2,3-oxidoreductase Valine, leucine and isoleucine degradation EC:1.3.99.12
kinetic law: MODEL1310110061#
type: Reaction

metaR NADtx
reactant: MODEL1310110061#
type: Reaction
fast: false
is described by: ECO:0000134
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: NOTES:
product: MODEL1310110061#
kinetic law: MODEL1310110061#
is: SBO:0000185
name: transport of NAD into peroxisome

metaR DCYTt
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10899995 NOTES:
kinetic law: MODEL1310110061#
name: deoxycytidine transport via diffusion
type: Reaction
reversible: true
is: SBO:0000185
product: MODEL1310110061#
is described by: ECO:0000000
reactant: MODEL1310110061#
fast: false

metaR FAOXC102C101m
kinetic law: MODEL1310110061#
product: MODEL1310110061#
reactant: MODEL1310110061#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: reduction(C10:2-->C10:1)m
type: Reaction

metaM itp e
notes: FORMULA: C10H11N4O14P3 CHARGE: -4 INCHI: InChI=1S/C10H15N4O14P3/c15-6-4(1-25-30(21,22)28-31(23,24)27-29(18,19)20)26-10(7(6)16)14-3-13-5-8(14)11-2-12-9(5)17/h2-4,6-7,10,15-16H,1H2,(H,21,22)(H,23,24)(H,11,12,17)(H2,18,19,20)/p-3/t4-,6-,7-,10-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00084 EHMN_ABBREVIATION: C00081
initial amount: NaN
name: ITP(3-)
is: HMDB00189
is: CHEBI:57614
has only substance units: false
is: SBO:0000247
constant: false
initial concentration: 1.0
boundary condition: false
type: Species

metaR r2359
is: SBO:0000185
product: MODEL1310110061#
reactant: MODEL1310110061#
fast: false
kinetic law: MODEL1310110061#
is described by: ECO:0000000
type: Reaction
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
name: Organic anion transporter 5 Utilized transport

metaM HC02149 m
initial concentration: 1.0
type: Species
initial amount: NaN
boundary condition: false
name: O-Propanoylcarnitine
is: CHEBI:28867
has only substance units: false
constant: false
is: SBO:0000247
notes: FORMULA: C10H19NO4 CHARGE: 0 INCHI: InChI=1S/C10H19NO4/c1-5-10(14)15-8(6-9(12)13)7-11(2,3)4/h8H,5-7H2,1-4H3

metaR r2199
kinetic law: MODEL1310110061#
is: SBO:0000185
fast: false
modifier: MODEL1310110061#
product: MODEL1310110061#
reversible: true
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.5
notes: GENE_ASSOCIATION: (6566.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
is described by: ECO:0000000
reactant: MODEL1310110061#
type: Reaction

metaM pmtcoa x
has only substance units: false
is: C00154
type: Species
name: Palmitoyl-CoA (n-C16:0CoA)
boundary condition: false
initial amount: NaN
is: SBO:0000247
constant: false
initial concentration: 1.0
is: CHEBI:57379
notes: FORMULA: C37H62N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00150 EHMN_ABBREVIATION: C00154
is: HMDB01338

metaR GLNSERNaEx
type: Reaction
fast: false
is described by: ECO:0000269
reactant: MODEL1310110061#
reversible: false
notes: GENE_ASSOCIATION: (6510.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14530974 NOTES:SAB see Kanai and Hediger 2004 (2003), PMID 14530974
is: SBO:0000185
kinetic law: MODEL1310110061#
modifier: MODEL1310110061#
name: L-serine/L-glutamine Na-dependent exchange (Gln-L in)
product: MODEL1310110061#

metaM fol e
type: Species
initial concentration: 1.0
boundary condition: false
has only substance units: false
is: SBO:0000247
name: Folate
is: HMDB00121
initial amount: NaN
constant: false
notes: FORMULA: C19H18N7O6 CHARGE: -1

metaR r2104
is: SBO:0000185
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
product: MODEL1310110061#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
is described by: ECO:0000000
modifier: MODEL1310110061#
type: Reaction
kinetic law: MODEL1310110061#
reactant: MODEL1310110061#
reversible: true
fast: false

http://identifiers.org/biomodels.db/MODEL1310110061#_cb70fd33_5053_4bac_bdc5_ac836577bedc
initial concentration: NaN
is: SBO:0000252
initial amount: NaN
constant: false
boundary condition: true
is encoded by: hsa:219
has only substance units: false
name: ALDH1B1
type: Species
is: P30837

metaR CYTK1
reversible: true
is version of: http://identifiers.org/ec-code/2.7.4.14
kinetic law: MODEL1310110061#
modifier: MODEL1310110061#
reactant: MODEL1310110061#
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: NOTES:
fast: false
is: SBO:0000176
type: Reaction
name: cytidylate kinase (CMP)
product: MODEL1310110061#
is described by: ECO:0000269

metaR r1573
kinetic law: MODEL1310110061#
is described by: ECO:0000000
reversible: true
reactant: MODEL1310110061#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
fast: false
product: MODEL1310110061#
type: Reaction
is: SBO:0000185
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1

http://identifiers.org/biomodels.db/MODEL1310110061#_0781b2a6_5886_473e_8fdd_70e32ec8a807
is: Q9Y2D0
is: SBO:0000252
initial concentration: NaN
initial amount: NaN
has only substance units: false
name: CA5B
type: Species
boundary condition: true
is encoded by: hsa:11238
constant: false

metaM ascb L e
initial amount: NaN
name: L-ascorbate
constant: false
type: Species
is: SBO:0000247
is: CHEBI:38290
boundary condition: false
notes: FORMULA: C6H7O6 CHARGE: -1 INCHI: InChI=1S/C6H8O6/c7-1-2(8)5-3(9)4(10)6(11)12-5/h2,5,7-10H,1H2/p-1/t2-,5+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00074
initial concentration: 1.0
has only substance units: false
is: HMDB00044

metaR EX 34dhphe LPAREN e RPAREN
kinetic law: MODEL1310110061#
reactant: MODEL1310110061#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 3,4-Dihydroxy-L-phenylalanine exchange
type: Reaction

metaR r0604
notes: GENE_ASSOCIATION: (6576.1) SUBSYSTEM: Unassigned EC Number: 2.3.1.168 Confidence Level: 0 AUTHORS: PMID:1943690 NOTES:
type: Reaction
reversible: false
kinetic law: MODEL1310110061#
product: MODEL1310110061#
reactant: MODEL1310110061#
is: SBO:0000176
modifier: MODEL1310110061#
is described by: ECO:0000000
fast: false
name: (S)-2-methylbutanoyl-CoA:enzyme N6-(dihydrolipoyl)lysine S-(2-methylbutanoyl)transferase Valine, leucine and isoleucine degradation EC:2.3.1.168

http://identifiers.org/biomodels.db/MODEL1310110061#_b37355a7_1089_4e13_a213_c11a542dd517
name: _BE966236_1_c
initial concentration: NaN
type: Species
is: SBO:0000252
has only substance units: false
initial amount: NaN
constant: false
boundary condition: true
is encoded by: hsa:BE966236

metaM 13dpg c
boundary condition: false
is: http://identifiers.org/pubchem.compound/3535
constant: false
initial concentration: 1.0
is: HMDB01270
notes: FORMULA: C3H4O10P2 CHARGE: -4 INCHI: 1/C3H8O10P2/c4-2(1-12-14(6,7)8)3(5)13-15(9,10)11/h2,4H,1H2,(H2,6,7,8)(H2,9,10,11)/t2-/m1/s1/f/h6-7,9-10H HEPATONET_1.0_ABBREVIATION: HC00214 EHMN_ABBREVIATION: C00236
is: CHEBI:57604
is: SBO:0000247
has only substance units: false
name: 3-Phospho-D-glyceroyl phosphate
type: Species
initial amount: NaN
is: C00236

metaM 2mop c
type: Species
initial amount: NaN
notes: FORMULA: C4H5O3 CHARGE: -1 INCHI: InChI=1S/C4H6O3/c1-3(2-5)4(6)7/h2-3H,1H3,(H,6,7)/p-1 HEPATONET_1.0_ABBREVIATION: HC00296 EHMN_ABBREVIATION: C00349
initial concentration: 1.0
constant: false
is: CHEBI:57700
name: 2-methyl-3-oxopropanoate
has only substance units: false
is: HMDB01172
is: SBO:0000247
boundary condition: false

metaM prostgh2 e
is: SBO:0000247
name: prostaglandin H2(1-)
constant: false
notes: FORMULA: C20H31O5 CHARGE: -1 INCHI: InChI=1S/C20H32O5/c1-2-3-6-9-15(21)12-13-17-16(18-14-19(17)25-24-18)10-7-4-5-8-11-20(22)23/h4,7,12-13,15-19,21H,2-3,5-6,8-11,14H2,1H3,(H,22,23)/p-1/b7-4-,13-12+/t15-,16+,17+,18-,19+/m0/s1 EHMN_ABBREVIATION: C00427
type: Species
initial amount: NaN
initial concentration: 1.0
is: CHEBI:57405
boundary condition: false
has only substance units: false
is: HMDB01381

metaR EX HC01104 LPAREN e RPAREN
kinetic law: MODEL1310110061#
reactant: MODEL1310110061#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of 4-nitrophenyl phosphate(2-)
type: Reaction

metaR ECOAH1m
is version of: http://identifiers.org/ec-code/4.2.1.17
product: MODEL1310110061#
reactant: MODEL1310110061#
name: 3-hydroxyacyl-CoA dehydratase (3-hydroxybutanoyl-CoA) (mitochondria)
fast: false
modifier: MODEL1310110061#
notes: GENE_ASSOCIATION: (549.1) or (3030.1) and (3032.1) or (1892.1) SUBSYSTEM: Tryptophan metabolism EC Number: 4.2.1.17 Confidence Level: 2 AUTHORS: PMID:7558027 NOTES:SAB for mito
reversible: true
is described by: ECO:0000304
type: Reaction
is: SBO:0000176
is version of: http://identifiers.org/ec-code/4.2.1.18
kinetic law: MODEL1310110061#
is version of: http://identifiers.org/ec-code/2.3.1.16

metaR r2198
reactant: MODEL1310110061#
type: Reaction
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.5
kinetic law: MODEL1310110061#
product: MODEL1310110061#
reversible: true
is: SBO:0000185
notes: GENE_ASSOCIATION: (6566.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
fast: false
is described by: ECO:0000000
modifier: MODEL1310110061#

metaR UDPtl
is described by: ECO:0000000
type: Reaction
is: SBO:0000185
name: udp intracellular transport
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 1 AUTHORS: NOTES:unknown mechanism for transport - not known if it is energy dependent or not, recycling and IC transport is important to get it to other areas of the cell (e.g. plasma membrane) - translocators have been found for ER and Golgi - none found for lysosome yet so non-mechanistic transporter added - in future this will need to be revised _when_ a translocator is found NJ
kinetic law: MODEL1310110061#
reactant: MODEL1310110061#
fast: false
product: MODEL1310110061#
reversible: true

metaR r2358
reversible: true
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
product: MODEL1310110061#
reactant: MODEL1310110061#
name: Organic anion transporter 5 Utilized transport
kinetic law: MODEL1310110061#
is described by: ECO:0000000
is: SBO:0000185
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110061#_ca0a3770_205e_46c3_a308_5a714f13e7ce
is encoded by: hsa:48
initial amount: NaN
boundary condition: true
name: ACO1
is: SBO:0000252
type: Species
constant: false
initial concentration: NaN
has only substance units: false
is: P21399

metaM acnam c
has only substance units: false
constant: false
name: N-acetylneuraminate
boundary condition: false
type: Species
notes: FORMULA: C11H18NO9 CHARGE: -1 INCHI: InChI=1S/C11H19NO9/c1-4(14)12-7-5(15)2-11(20,10(18)19)21-9(7)8(17)6(16)3-13/h5-9,13,15-17,20H,2-3H2,1H3,(H,12,14)(H,18,19)/p-1/t5-,6+,7+,8+,9+,11?/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00244 EHMN_ABBREVIATION: C00270
initial amount: NaN
initial concentration: 1.0
is: SBO:0000247
is: CHEBI:35418
is: HMDB00230

metaR r2105
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
modifier: MODEL1310110061#
reversible: true
is described by: ECO:0000000
type: Reaction
product: MODEL1310110061#
fast: false
reactant: MODEL1310110061#
kinetic law: MODEL1310110061#
is: SBO:0000185
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110061#_b172b9fd_f92d_4879_9e54_1e2df8c6847b
is encoded by: hsa:5476
constant: false
initial concentration: NaN
initial amount: NaN
is: P10619
is: SBO:0000252
name: CTSA
has only substance units: false
type: Species
boundary condition: true

metaM cholp c
name: choline phosphate(1-)
initial concentration: 1.0
has only substance units: false
boundary condition: false
is: SBO:0000247
type: Species
initial amount: NaN
is: CHEBI:295975
constant: false
notes: FORMULA: C5H13NO4P CHARGE: -1 INCHI: InChI=1S/C5H14NO4P/c1-6(2,3)4-5-10-11(7,8)9/h4-5H2,1-3H3,(H-,7,8,9)/p-1 HEPATONET_1.0_ABBREVIATION: HC00442 EHMN_ABBREVIATION: C00588

metaM tetpent3coa c
constant: false
boundary condition: false
initial amount: NaN
type: Species
is: C16167
name: tetracosapentaenoyl coenzyme A, n-3
has only substance units: false
notes: FORMULA: C45H68N7O17P3S CHARGE: -4 INCHI: InChI=1/C45H72N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-24-25-36(54)73-29-28-47-35(53)26-27-48-43(57)40(56)45(2,3)31-66-72(63,64)69-71(61,62)65-30-34-39(68-70(58,59)60)38(55)44(67-34)52-33-51-37-41(46)49-32-50-42(37)52/h5-6,8-9,11-12,14-15,17-18,32-34,38-40,44,55-56H,4,7,10,13,16,19-31H2,1-3H3,(H,47,53)(H,48,57)(H,61,62)(H,63,64)(H2,46,49,50)(H2,58,59,60)/b6-5-,9-8-,12-11-,15-14-,18-17-/t34-,38-,39-,40?,44-/m1/s1
initial concentration: 1.0
is: SBO:0000247

metaM gthrd m
boundary condition: false
is: CHEBI:57925
notes: FORMULA: C10H16N3O6S CHARGE: -1 INCHI: InChI=1S/C10H17N3O6S/c11-5(10(18)19)1-2-7(14)13-6(4-20)9(17)12-3-8(15)16/h5-6,20H,1-4,11H2,(H,12,17)(H,13,14)(H,15,16)(H,18,19)/p-1/t5-,6-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00056 EHMN_ABBREVIATION: C00051
is: SBO:0000247
name: glutathionate(1-)
type: Species
initial amount: NaN
initial concentration: 1.0
constant: false
is: HMDB00125
has only substance units: false

metaM arachd c
constant: false
notes: FORMULA: C20H31O2 CHARGE: -1 INCHI: InChI=1S/C20H32O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20(21)22/h6-7,9-10,12-13,15-16H,2-5,8,11,14,17-19H2,1H3,(H,21,22)/p-1/b7-6-,10-9-,13-12-,16-15-
type: Species
is: CHEBI:32395
initial amount: NaN
has only substance units: false
is: SBO:0000247
name: arachidonate
initial concentration: 1.0
is: HMDB01043
boundary condition: false

metaR r0680
is: SBO:0000176
kinetic law: MODEL1310110061#
notes: GENE_ASSOCIATION: (AI373818.1) or (54677.1) SUBSYSTEM: CoA catabolism EC Number: 2.7.1.33 Confidence Level: 0 AUTHORS: PMID:10625688,PMID:13630913,PMID:15105273,PMID:15659606,PMID:16040613 NOTES:
reversible: true
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/2.3.1.137
fast: false
type: Reaction
name: ATP:pantothenate 4-phosphotransferase Pantothenate and CoA biosynthesis EC:2.7.1.33
reactant: MODEL1310110061#
modifier: MODEL1310110061#
product: MODEL1310110061#

metaR ACGAMPM
modifier: MODEL1310110061#
is described by: ECO:0000269
reactant: MODEL1310110061#
reversible: true
kinetic law: MODEL1310110061#
notes: GENE_ASSOCIATION: (5238.1) SUBSYSTEM: Aminosugar metabolism EC Number: 5.4.2.3 Confidence Level: 4 AUTHORS: PMID:11004509 NOTES:NCD
is version of: http://identifiers.org/ec-code/5.4.2.3
product: MODEL1310110061#
type: Reaction
fast: false
is: SBO:0000176
name: phosphoacetylglucosamine mutase

metaM mercplac c
type: Species
is: SBO:0000247
is: C05823
notes: FORMULA: C3H5O3S CHARGE: -1 INCHI: InChI=1/C3H6O3S/c4-2(1-7)3(5)6/h2,4,7H,1H2,(H,5,6) EHMN_ABBREVIATION: C05823
is: HMDB02127
constant: false
boundary condition: false
is: http://identifiers.org/pubchem.compound/8118
initial amount: NaN
initial concentration: 1.0
name: 3-Mercaptolactate
has only substance units: false

metaR ETF
is: SBO:0000176
notes: GENE_ASSOCIATION: (2109.2) and (2108.1) or (2109.1) and (2108.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: PMID:3170610,PMID:7601336 NOTES:TV (5/4/05) Voet p.571
product: MODEL1310110061#
kinetic law: MODEL1310110061#
name: electron transfer flavoprotein
reactant: MODEL1310110061#
fast: false
modifier: MODEL1310110061#
is described by: ECO:0000000
type: Reaction
reversible: false

metaM maltpt e
is: SBO:0000247
initial concentration: 1.0
notes: FORMULA: C30H52O26 CHARGE: 0 EHMN_ABBREVIATION: CE2835
name: maltopentaose
constant: false
has only substance units: false
initial amount: NaN
boundary condition: false
is: C02052
is: HMDB01296
type: Species
is: http://identifiers.org/pubchem.compound/5141

metaR GLNASNNaEx
is described by: ECO:0000269
name: L-glutamine/L-asparagine Na-dependent exchange (Gln-L in)
fast: false
reactant: MODEL1310110061#
kinetic law: MODEL1310110061#
modifier: MODEL1310110061#
product: MODEL1310110061#
notes: GENE_ASSOCIATION: (6510.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14530974 NOTES:SAB see Kanai and Hediger 2004 (2003), PMID 14530974
reversible: false
type: Reaction
is: SBO:0000185

metaM pmtcoa r
has only substance units: false
type: Species
is: C00154
initial amount: NaN
is: CHEBI:3454
initial concentration: 1.0
name: Palmitoyl-CoA (n-C16:0CoA)
is: SBO:0000247
boundary condition: false
constant: false
is: HMDB01338
notes: FORMULA: C37H62N7O17P3S CHARGE: -4

http://identifiers.org/biomodels.db/MODEL1310110061#_61877302_6630_4791_aa1c_9be5b84d3b46
boundary condition: true
has only substance units: false
is: Q9HC58
is encoded by: hsa:57419
is: SBO:0000252
type: Species
constant: false
name: SLC24A3
initial concentration: NaN
initial amount: NaN

metaM andrstndn r
initial amount: NaN
constant: false
has only substance units: false
is: SBO:0000247
boundary condition: false
notes: FORMULA: C19H26O2 CHARGE: 0 INCHI: InChI=1S/C19H26O2/c1-18-9-7-13(20)11-12(18)3-4-14-15-5-6-17(21)19(15,2)10-8-16(14)18/h11,14-16H,3-10H2,1-2H3/t14-,15-,16-,18-,19-/m0/s1 EHMN_ABBREVIATION: C00280
name: androst-4-ene-3,17-dione
is: HMDB00053
initial concentration: 1.0
is: CHEBI:16422
type: Species

metaM trp L e
name: L-tryptophan
constant: false
has only substance units: false
is: CHEBI:16828
initial concentration: 1.0
initial amount: NaN
boundary condition: false
type: Species
notes: FORMULA: C11H12N2O2 CHARGE: 0 INCHI: InChI=1S/C11H12N2O2/c12-9(11(14)15)5-7-6-13-10-4-2-1-3-8(7)10/h1-4,6,9,13H,5,12H2,(H,14,15)/t9-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00080
is: HMDB00929
is: SBO:0000247

metaR CYTK3
product: MODEL1310110061#
reversible: true
name: cytidylate kinase (CMP)(GTP)
reactant: MODEL1310110061#
kinetic law: MODEL1310110061#
modifier: MODEL1310110061#
notes: GENE_ASSOCIATION: (26289.1) or (26289.2) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: PMID:10215863 NOTES:
is version of: http://identifiers.org/ec-code/2.7.4.3
fast: false
is: SBO:0000176
type: Reaction
is described by: ECO:0000269

http://identifiers.org/biomodels.db/MODEL1310110061#_e007e25d_55cf_41b2_a888_7a4ada84bf7f
is: SBO:0000252
name: UPP2
initial concentration: NaN
type: Species
constant: false
has only substance units: false
is encoded by: hsa:151531
initial amount: NaN
is: O95045
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110061#_27bea779_bc87_4913_8f59_4d8f0dff4a8d
constant: false
is encoded by: hsa:7941
initial amount: NaN
has only substance units: false
initial concentration: NaN
boundary condition: true
is: SBO:0000252
name: PLA2G7
type: Species
is: Q13093

metaM biocyt e
has only substance units: false
initial amount: NaN
is: SBO:0000247
is: C05552
constant: false
type: Species
is: http://identifiers.org/pubchem.compound/7886
initial concentration: 1.0
is: HMDB03134
name: Biocytin
notes: FORMULA: C16H28N4O4S CHARGE: 0 INCHI: InChI=1/C16H28N4O4S/c17-10(15(22)23)5-3-4-8-18-13(21)7-2-1-6-12-14-11(9-25-12)19-16(24)20-14/h10-12,14H,1-9,17H2,(H,18,21)(H,22,23)(H2,19,20,24)/t10-,11-,12-,14-/m0/s1 EHMN_ABBREVIATION: C05552
boundary condition: false

metaR r1579
is: SBO:0000185
fast: false
kinetic law: MODEL1310110061#
reversible: true
type: Reaction
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is described by: ECO:0000000
reactant: MODEL1310110061#
product: MODEL1310110061#

metaR GLCAASE8ly
kinetic law: MODEL1310110061#
is described by: ECO:0000269
reactant: MODEL1310110061#
name: beta-glucuronidase, lysosomal
is: SBO:0000176
product: MODEL1310110061#
is version of: http://identifiers.org/ec-code/3.2.1.31
reversible: false
modifier: MODEL1310110061#
type: Reaction
notes: GENE_ASSOCIATION: (2990.1) SUBSYSTEM: Hyaluronan metabolism EC Number: 3.2.1.31 Confidence Level: 4 AUTHORS: PMID:3468507,PMID:3924735,PMID:3987656 NOTES:NCD
fast: false

metaM gthrd r
boundary condition: false
initial amount: NaN
name: glutathionate(1-)
notes: FORMULA: C10H16N3O6S CHARGE: -1 INCHI: InChI=1S/C10H17N3O6S/c11-5(10(18)19)1-2-7(14)13-6(4-20)9(17)12-3-8(15)16/h5-6,20H,1-4,11H2,(H,12,17)(H,13,14)(H,15,16)(H,18,19)/p-1/t5-,6-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00056 EHMN_ABBREVIATION: C00051
initial concentration: 1.0
is: SBO:0000247
has only substance units: false
type: Species
constant: false
is: CHEBI:57925
is: HMDB00125

http://identifiers.org/biomodels.db/MODEL1310110061#_a253f96f_d731_4dd6_8d53_1090932241f5
name: MTMR3
has only substance units: false
is encoded by: hsa:8897
type: Species
is: SBO:0000252
boundary condition: true
initial concentration: NaN
initial amount: NaN
constant: false

metaR BILIRUBt2
notes: GENE_ASSOCIATION: (10599.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10358072,PMID:12507753,PMID:9334206 NOTES:NJ
type: Reaction
name: bilirubin transport via bicarbonate countertransport
modifier: MODEL1310110061#
reversible: true
is described by: ECO:0000269
reactant: MODEL1310110061#
kinetic law: MODEL1310110061#
is: SBO:0000185
fast: false
product: MODEL1310110061#

metaM xol7ah2al m
is: SBO:0000247
notes: FORMULA: C27H46O3 CHARGE: 0 INCHI: InChI=1S/C27H46O3/c1-17(16-28)6-5-7-18(2)21-8-9-22-25-23(11-13-27(21,22)4)26(3)12-10-20(29)14-19(26)15-24(25)30/h16-25,29-30H,5-15H2,1-4H3/t17?,18-,19+,20-,21-,22+,23+,24-,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01454 EHMN_ABBREVIATION: C05445
is: HMDB06894
name: 3alpha,7alpha-dihydroxy-5beta-cholestan-26-al
initial concentration: 1.0
constant: false
initial amount: NaN
has only substance units: false
type: Species
boundary condition: false
is: CHEBI:27428

http://identifiers.org/biomodels.db/MODEL1310110061#_84f52bf4_2063_4bd8_99ef_86908d144d77
constant: false
is: SBO:0000252
type: Species
boundary condition: true
initial concentration: NaN
has only substance units: false
name: EHHADH
initial amount: NaN
is: Q9NY65
is encoded by: hsa:1962

metaM 44mzym r
is: CHEBI:18364
notes: FORMULA: C29H48O CHARGE: 0 INCHI: InChI=1S/C29H48O/c1-19(2)9-8-10-20(3)22-12-13-23-21-11-14-25-27(4,5)26(30)16-18-29(25,7)24(21)15-17-28(22,23)6/h9,20,22-23,25-26,30H,8,10-18H2,1-7H3/t20-,22-,23+,25+,26+,28-,29-/m1/s1 EHMN_ABBREVIATION: C05108
is: SBO:0000247
type: Species
initial amount: NaN
constant: false
name: 14-demethyllanosterol
initial concentration: 1.0
boundary condition: false
has only substance units: false
is: HMDB01286

metaM prostgh2 c
boundary condition: false
type: Species
initial concentration: 1.0
has only substance units: false
notes: FORMULA: C20H31O5 CHARGE: -1 INCHI: InChI=1S/C20H32O5/c1-2-3-6-9-15(21)12-13-17-16(18-14-19(17)25-24-18)10-7-4-5-8-11-20(22)23/h4,7,12-13,15-19,21H,2-3,5-6,8-11,14H2,1H3,(H,22,23)/p-1/b7-4-,13-12+/t15-,16+,17+,18-,19+/m0/s1 EHMN_ABBREVIATION: C00427
initial amount: NaN
is: SBO:0000247
is: CHEBI:57405
constant: false
is: HMDB01381
name: prostaglandin H2(1-)

http://identifiers.org/biomodels.db/MODEL1310110061#_5f703e93_ef6a_4fb6_937b_865f5fbecbf1
type: Species
initial amount: NaN
is: SBO:0000252
is encoded by: hsa:AI620219
initial concentration: NaN
has only substance units: false
constant: false
boundary condition: true
name: _AI620219_1_m

metaM tetpent6coa c
initial amount: NaN
has only substance units: false
is: SBO:0000247
notes: FORMULA: C45H68N7O17P3S CHARGE: -4 INCHI: InChI=1/C45H72N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-24-25-36(54)73-29-28-47-35(53)26-27-48-43(57)40(56)45(2,3)31-66-72(63,64)69-71(61,62)65-30-34-39(68-70(58,59)60)38(55)44(67-34)52-33-51-37-41(46)49-32-50-42(37)52/h8-9,11-12,14-15,17-18,20-21,32-34,38-40,44,55-56H,4-7,10,13,16,19,22-31H2,1-3H3,(H,47,53)(H,48,57)(H,61,62)(H,63,64)(H2,46,49,50)(H2,58,59,60)/b9-8-,12-11-,15-14-,18-17-,21-20-/t34-,38-,39-,40?,44-/m1/s1
initial concentration: 1.0
boundary condition: false
is: C16172
constant: false
name: tetracosapentaenoyl coenzyme A, n-6
type: Species

metaR RE2660C
product: MODEL1310110061#
notes: GENE_ASSOCIATION: SUBSYSTEM: Tetrahydrobiopterin metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:9647871 NOTES:
name: RE2660
is: SBO:0000176
is described by: ECO:0000000
type: Reaction
kinetic law: MODEL1310110061#
reactant: MODEL1310110061#
fast: false
reversible: true

metaR EX asp L LPAREN e RPAREN
kinetic law: MODEL1310110061#
reactant: MODEL1310110061#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: L-Aspartate exchange
type: Reaction

metaM trp L c
boundary condition: false
is: SBO:0000247
has only substance units: false
notes: FORMULA: C11H12N2O2 CHARGE: 0 INCHI: InChI=1S/C11H12N2O2/c12-9(11(14)15)5-7-6-13-10-4-2-1-3-8(7)10/h1-4,6,9,13H,5,12H2,(H,14,15)/t9-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00080
constant: false
name: L-tryptophan
initial concentration: 1.0
is: HMDB00929
initial amount: NaN
is: CHEBI:16828
type: Species

metaR r1578
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
product: MODEL1310110061#
type: Reaction
reversible: true
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is described by: ECO:0000000
kinetic law: MODEL1310110061#
fast: false
reactant: MODEL1310110061#

metaM 2mp2coa m
type: Species
constant: false
boundary condition: false
initial amount: NaN
is: CHEBI:27754
is: SBO:0000247
has only substance units: false
notes: FORMULA: C25H36N7O17P3S CHARGE: -4 INCHI: InChI=1S/C25H40N7O17P3S/c1-13(2)24(37)53-8-7-27-15(33)5-6-28-22(36)19(35)25(3,4)10-46-52(43,44)49-51(41,42)45-9-14-18(48-50(38,39)40)17(34)23(47-14)32-12-31-16-20(26)29-11-30-21(16)32/h11-12,14,17-19,23,34-35H,1,5-10H2,2-4H3,(H,27,33)(H,28,36)(H,41,42)(H,43,44)(H2,26,29,30)(H2,38,39,40)/t14-,17-,18-,19+,23-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01122 EHMN_ABBREVIATION: C03460
is: HMDB01011
name: 2-Methylprop-2-enoyl-CoA
initial concentration: 1.0

metaR CYTK2
is described by: ECO:0000269
kinetic law: MODEL1310110061#
name: cytidylate kinase (dCMP)
reactant: MODEL1310110061#
is version of: http://identifiers.org/ec-code/2.7.4.14
modifier: MODEL1310110061#
is: SBO:0000176
type: Reaction
product: MODEL1310110061#
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: NOTES:
reversible: true
fast: false

metaR RE1523M
fast: false
product: MODEL1310110061#
type: Reaction
name: RE1523
is: SBO:0000176
kinetic law: MODEL1310110061#
reversible: true
is version of: http://identifiers.org/ec-code/4.2.1.17
is version of: http://identifiers.org/ec-code/1.1.1.35
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (1892.1) or (3030.1) or (1962.1) or (3032.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.17 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:7923814,PMID:9568246,PMID:9920399 NOTES:
is version of: http://identifiers.org/ec-code/2.3.1.16
reactant: MODEL1310110061#
modifier: MODEL1310110061#

metaM 5aop m
name: 5-Amino-4-oxopentanoate
has only substance units: false
constant: false
is: CHEBI:17549
initial concentration: 1.0
is: SBO:0000247
is: C00430
notes: FORMULA: C5H9NO3 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00349 EHMN_ABBREVIATION: C00430
is: HMDB01149
type: Species
boundary condition: false
initial amount: NaN

metaM arachd e
has only substance units: false
initial concentration: 1.0
is: SBO:0000247
type: Species
constant: false
is: HMDB01043
name: arachidonate
notes: FORMULA: C20H31O2 CHARGE: -1 INCHI: InChI=1S/C20H32O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20(21)22/h6-7,9-10,12-13,15-16H,2-5,8,11,14,17-19H2,1H3,(H,21,22)/p-1/b7-6-,10-9-,13-12-,16-15-
boundary condition: false
initial amount: NaN
is: CHEBI:32395

http://identifiers.org/biomodels.db/MODEL1310110061#_fce5d6fd_b6c8_4084_a963_9588fe377580
is: P22680
has only substance units: false
is: SBO:0000252
name: CYP7A1
boundary condition: true
is encoded by: hsa:1581
initial concentration: NaN
constant: false
initial amount: NaN
type: Species

metaR LNLCt
name: Linoleic acid (n-C18:2) transport in via diffusion
product: MODEL1310110061#
fast: false
reversible: true
kinetic law: MODEL1310110061#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11788354,PMID:12864740 NOTES:NJ
reactant: MODEL1310110061#
type: Reaction
is described by: ECO:0000000

metaR PHCHGSm
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Arginine and Proline Metabolism EC Number: Confidence Level: 2 AUTHORS: PMID:12660328,PMID:15849464 NOTES:taken from KEGG map. No enzyme assigned, so assumed this is a non-enzymatic reaction. NCD
kinetic law: MODEL1310110061#
product: MODEL1310110061#
type: Reaction
is described by: ECO:0000000
is: SBO:0000176
fast: false
name: L-1-Pyrroline-3-hydroxy-5-carboxylate spontaneous conversion to L-4-Hydroxyglutamate semialdehyde, mitochondrial
reactant: MODEL1310110061#

http://identifiers.org/biomodels.db/MODEL1310110061#_2688222e_7f87_47ab_8d6c_296596799d03
initial concentration: NaN
constant: false
initial amount: NaN
is encoded by: hsa:AL525798
is: SBO:0000252
boundary condition: true
has only substance units: false
type: Species
name: _AL525798_1_c

metaR EX 7dhf LPAREN e RPAREN
kinetic law: MODEL1310110061#
reactant: MODEL1310110061#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: heptaglutamyl folate (DHF) exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110061#_48693783_b2d1_4455_a510_8e955cd6944e
has only substance units: false
initial concentration: NaN
type: Species
is: SBO:0000252
name: SLC23A1
is encoded by: hsa:9963
initial amount: NaN
is: Q9UHI7
constant: false
boundary condition: true

metaR PItx
is described by: ECO:0000000
product: MODEL1310110061#
reversible: true
name: Phosphate transporter, peroxisome
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 1 AUTHORS: NOTES:diffusion NJ
reactant: MODEL1310110061#
fast: false
is: SBO:0000185
kinetic law: MODEL1310110061#
type: Reaction

metaR EX pydx LPAREN e RPAREN
kinetic law: MODEL1310110061#
reactant: MODEL1310110061#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for Pyridoxal
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110061#_0de0f927_7567_49cd_ba29_746fe49bbd56
type: Species
initial amount: NaN
name: CRLS1
boundary condition: true
has only substance units: false
is: Q9UJA2
initial concentration: NaN
constant: false
is encoded by: hsa:54675
is: SBO:0000252

metaM clpndcoa x
is: HMDB06267
is: http://identifiers.org/pubchem.compound/47205476
name: clupanodonyl CoA
constant: false
type: Species
notes: FORMULA: C43H64N7O17P3S CHARGE: -4 INCHI: InChI=1/C43H68N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-34(52)71-27-26-45-33(51)24-25-46-41(55)38(54)43(2,3)29-64-70(61,62)67-69(59,60)63-28-32-37(66-68(56,57)58)36(53)42(65-32)50-31-49-35-39(44)47-30-48-40(35)50/h5-6,8-9,11-12,14-15,17-18,30-32,36-38,42,53-54H,4,7,10,13,16,19-29H2,1-3H3,(H,45,51)(H,46,55)(H,59,60)(H,61,62)(H2,44,47,48)(H2,56,57,58)/p-4/b6-5-,9-8-,12-11-,15-14-,18-17-/t32-,36+,37+,38?,42-/m0/s1
has only substance units: false
initial concentration: 1.0
boundary condition: false
initial amount: NaN
is: C16166
is: SBO:0000247

metaR TSTSTERONEtr
is described by: ECO:0000000
kinetic law: MODEL1310110061#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: NOTES:specific mechanism not known, proton dependence for trans-mit transport has been suggested, however directionality and stoichiometry has not yet been elucidated. see PMID: 12770731 and others NJ
type: Reaction
product: MODEL1310110061#
fast: false
reactant: MODEL1310110061#
is: SBO:0000185
reversible: true
name: testosterone intracellular transport

metaR r2108
is described by: ECO:0000000
type: Reaction
reactant: MODEL1310110061#
fast: false
reversible: true
kinetic law: MODEL1310110061#
is: SBO:0000185
modifier: MODEL1310110061#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
product: MODEL1310110061#

http://identifiers.org/biomodels.db/MODEL1310110061#_70755499_9663_434b_844f_e95e8b6e7757
type: Species
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:83884
has only substance units: false
name: SLC25A2
initial concentration: NaN
boundary condition: true
is: Q9BXI2
constant: false

metaR r2506
reversible: true
type: Reaction
product: MODEL1310110061#
kinetic law: MODEL1310110061#
name: Utilized transport
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:17466261 NOTES:
reactant: MODEL1310110061#
is described by: ECO:0000000
fast: false

metaR RE1534M
product: MODEL1310110061#
type: Reaction
reactant: MODEL1310110061#
notes: GENE_ASSOCIATION: (10449.1) or (3032.1) or (3030.1) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.16 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:7923814,PMID:9568246,PMID:9920399 NOTES:
fast: false
reversible: true
modifier: MODEL1310110061#
is: SBO:0000176
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/4.2.1.17
kinetic law: MODEL1310110061#
is version of: http://identifiers.org/ec-code/2.3.1.16
name: RE1534

metaR RE1709C
reactant: MODEL1310110061#
notes: GENE_ASSOCIATION: SUBSYSTEM: Tetrahydrobiopterin metabolism EC Number: 4.2.1.96 Confidence Level: 0 AUTHORS: PMID:10727395,PMID:8921004 NOTES:
is described by: ECO:0000000
kinetic law: MODEL1310110061#
reversible: true
type: Reaction
fast: false
is: SBO:0000176
product: MODEL1310110061#
name: RE1709

metaM biocyt c
initial amount: NaN
is: SBO:0000247
is: C05552
type: Species
constant: false
initial concentration: 1.0
is: http://identifiers.org/pubchem.compound/7886
name: Biocytin
notes: FORMULA: C16H28N4O4S CHARGE: 0 INCHI: InChI=1/C16H28N4O4S/c17-10(15(22)23)5-3-4-8-18-13(21)7-2-1-6-12-14-11(9-25-12)19-16(24)20-14/h10-12,14H,1-9,17H2,(H,18,21)(H,22,23)(H2,19,20,24)/t10-,11-,12-,14-/m0/s1 EHMN_ABBREVIATION: C05552
boundary condition: false
has only substance units: false
is: HMDB03134

metaR CYTK5
is described by: ECO:0000269
fast: false
reactant: MODEL1310110061#
name: cytidylate kinase (dCMP)
is: SBO:0000176
type: Reaction
product: MODEL1310110061#
kinetic law: MODEL1310110061#
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
reversible: true
is version of: http://identifiers.org/ec-code/2.7.4.14
modifier: MODEL1310110061#

http://identifiers.org/biomodels.db/MODEL1310110061#_27377f60_34fd_40e5_b499_a30c640a34a1
initial amount: NaN
has only substance units: false
constant: false
type: Species
is: Q02338
is: SBO:0000252
initial concentration: NaN
boundary condition: true
is encoded by: hsa:622
name: BDH1

http://identifiers.org/biomodels.db/MODEL1310110061#_27c5440a_5d8a_46c8_8daf_45be8dd1408d
has only substance units: false
initial concentration: NaN
initial amount: NaN
is: Q9H845
is: SBO:0000252
name: ACAD9
is encoded by: hsa:28976
boundary condition: true
type: Species
constant: false

metaM dolglcp L c
constant: false
has only substance units: false
notes: FORMULA: C1140H1868O90P10 CHARGE: -10 INCHI: InChI=1S/C31H55O9P/c1-22(2)11-7-12-23(3)13-8-14-24(4)15-9-16-25(5)17-10-18-26(6)19-20-38-41(36,37)40-31-30(35)29(34)28(33)27(21-32)39-31/h11,13,15,17,26-35H,7-10,12,14,16,18-21H2,1-6H3,(H,36,37)/b23-13+,24-15+,25-17-/t26?,27-,28-,29+,30-,31+/m1/s1
type: Species
is: SBO:0000247
initial concentration: 1.0
is: CHEBI:15812
initial amount: NaN
name: Dolichyl beta-D-glucosyl phosphate, human liver homolog
boundary condition: false

metaR NCKt
product: MODEL1310110061#
reactant: MODEL1310110061#
is described by: ECO:0000269
type: Reaction
modifier: MODEL1310110061#
fast: false
reversible: true
notes: GENE_ASSOCIATION: (123041.2) or (57419.1) or (9187.1) or (123041.3) or (25769.1) or (123041.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10484410,PMID:10662833,PMID:11294880,PMID:12379639,PMID:14770312,PMID:9478004 NOTES:NCD
kinetic law: MODEL1310110061#
name: Na+/Ca2+-K+ exchange
is: SBO:0000185

metaM cholp g
initial concentration: 1.0
boundary condition: false
name: choline phosphate(1-)
has only substance units: false
notes: FORMULA: C5H13NO4P CHARGE: -1 INCHI: InChI=1S/C5H14NO4P/c1-6(2,3)4-5-10-11(7,8)9/h4-5H2,1-3H3,(H-,7,8,9)/p-1 HEPATONET_1.0_ABBREVIATION: HC00442 EHMN_ABBREVIATION: C00588
is: C00588
initial amount: NaN
is: CHEBI:295975
constant: false
type: Species
is: SBO:0000247

metaR SERGLNexR
fast: false
kinetic law: MODEL1310110061#
modifier: MODEL1310110061#
reactant: MODEL1310110061#
type: Reaction
is described by: ECO:0000304
reversible: true
name: L-Serine/Glutamine reversible exchange
product: MODEL1310110061#
notes: GENE_ASSOCIATION: (56301.1) and (6520.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10734121,PMID:10863037,PMID:14770310 NOTES:
is: SBO:0000185

metaR r2109
is described by: ECO:0000000
product: MODEL1310110061#
type: Reaction
is: SBO:0000185
reactant: MODEL1310110061#
modifier: MODEL1310110061#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
reversible: true
kinetic law: MODEL1310110061#
fast: false

http://identifiers.org/biomodels.db/MODEL1310110061#_da4cb3a2_d6a5_4ac0_8a1e_e21d02c6f961
is: SBO:0000252
initial amount: NaN
initial concentration: NaN
constant: false
type: Species
name: RBAK
boundary condition: true
is encoded by: hsa:57786
has only substance units: false
is: Q9NYW8

metaR CYTK4
kinetic law: MODEL1310110061#
reactant: MODEL1310110061#
is: SBO:0000176
type: Reaction
modifier: MODEL1310110061#
notes: GENE_ASSOCIATION: (26289.1) or (26289.2) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: PMID:10215863 NOTES:
is version of: http://identifiers.org/ec-code/2.7.4.3
name: cytidylate kinase (dCMP)(GTP)
reversible: true
product: MODEL1310110061#
fast: false
is described by: ECO:0000269

metaR r2507
is described by: ECO:0000000
fast: false
is: SBO:0000185
product: MODEL1310110061#
type: Reaction
name: Utilized transport
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:17466261 NOTES:
kinetic law: MODEL1310110061#
reactant: MODEL1310110061#
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110061#_fee3e919_f0dc_4a34_be44_affba294a6a5
initial concentration: NaN
initial amount: NaN
constant: false
name: BAAT
boundary condition: true
is: SBO:0000252
is: Q14032
has only substance units: false
type: Species
is encoded by: hsa:570

http://identifiers.org/biomodels.db/MODEL1310110061#_5b57ddb0_a32b_4db9_84e0_00737d5d57ce
initial amount: NaN
is encoded by: hsa:5334
name: PLCL1
initial concentration: NaN
constant: false
is: Q15111
has only substance units: false
boundary condition: true
type: Species
is: SBO:0000252

metaR r1576
product: MODEL1310110061#
reversible: true
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is: SBO:0000185
kinetic law: MODEL1310110061#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is described by: ECO:0000000
fast: false
reactant: MODEL1310110061#

metaM aacoa x
type: Species
has only substance units: false
is: CHEBI:57286
constant: false
is: SBO:0000247
name: acetoacetyl-CoA(4-)
initial amount: NaN
boundary condition: false
is: HMDB01484
notes: FORMULA: C25H36N7O18P3S CHARGE: -4 INCHI: InChI=1S/C25H40N7O18P3S/c1-13(33)8-16(35)54-7-6-27-15(34)4-5-28-23(38)20(37)25(2,3)10-47-53(44,45)50-52(42,43)46-9-14-19(49-51(39,40)41)18(36)24(48-14)32-12-31-17-21(26)29-11-30-22(17)32/h11-12,14,18-20,24,36-37H,4-10H2,1-3H3,(H,27,34)(H,28,38)(H,42,43)(H,44,45)(H2,26,29,30)(H2,39,40,41)/p-4/t14-,18-,19-,20+,24-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00282 EHMN_ABBREVIATION: C00332
initial concentration: 1.0

metaM ksii core2 l
name: keratan sulfate II (core 2-linked)
initial concentration: 1.0
is: HMDB01014
is: CHEBI:57255
type: Species
notes: FORMULA: C81H129N6O67S3X CHARGE: -4
initial amount: NaN
boundary condition: false
has only substance units: false
is: SBO:0000247
constant: false

metaM thbpt4acam n
boundary condition: false
is: CHEBI:15374
is: HMDB02281
type: Species
is: SBO:0000247
initial concentration: 1.0
has only substance units: false
notes: FORMULA: C9H15N5O4 CHARGE: 0 INCHI: InChI=1S/C9H15N5O4/c1-3(15)5(16)4-2-11-6-9(18,14-4)7(17)13-8(10)12-6/h3-5,14-16,18H,2H2,1H3,(H3,10,11,12,13,17) EHMN_ABBREVIATION: CE1951
initial amount: NaN
name: 4a-hydroxytetrahydrobiopterin
constant: false

metaR MECOALm
kinetic law: MODEL1310110061#
fast: false
product: MODEL1310110061#
reversible: true
reactant: MODEL1310110061#
type: Reaction
is version of: http://identifiers.org/ec-code/6.2.1.4
name: mesaconate--CoA ligase (ADP-forming), mitochondrial
modifier: MODEL1310110061#
is described by: ECO:0000212
notes: GENE_ASSOCIATION: (8802.1 and 8803.1) SUBSYSTEM: C5-branched dibasic acid metabolism EC Number: 6.2.1.5 Confidence Level: 1 AUTHORS: PMID:13783048 NOTES:NCD
is version of: http://identifiers.org/ec-code/6.2.1.5
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110061#_00a1312a_1ee5_433b_bdfa_d0f2b2cb746c
constant: false
is encoded by: hsa:7001
name: PRDX2
type: Species
initial concentration: NaN
initial amount: NaN
has only substance units: false
boundary condition: true
is: SBO:0000252

metaR DM kdn c
kinetic law: MODEL1310110061#
reactant: MODEL1310110061#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 0 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: false
name: DM kdn(c)
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110061#_61b1456f_023f_4a06_872e_9ea8934e6f55
initial concentration: NaN
initial amount: NaN
is: SBO:0000252
constant: false
has only substance units: false
type: Species
is encoded by: hsa:7296
boundary condition: true
name: TXNRD1

metaM 3hibutcoa m
notes: FORMULA: C25H38N7O18P3S CHARGE: -4 INCHI: InChI=1S/C25H42N7O18P3S/c1-13(8-33)24(38)54-7-6-27-15(34)4-5-28-22(37)19(36)25(2,3)10-47-53(44,45)50-52(42,43)46-9-14-18(49-51(39,40)41)17(35)23(48-14)32-12-31-16-20(26)29-11-30-21(16)32/h11-14,17-19,23,33,35-36H,4-10H2,1-3H3,(H,27,34)(H,28,37)(H,42,43)(H,44,45)(H2,26,29,30)(H2,39,40,41)/t13-,14+,17+,18+,19-,23+/m0/s1 EHMN_ABBREVIATION: C06000
is: CHEBI:28259
constant: false
initial amount: NaN
has only substance units: false
name: (S)-3-Hydroxyisobutyryl-CoA
is: SBO:0000247
is: HMDB01052
boundary condition: false
type: Species
initial concentration: 1.0

metaM estrone c
boundary condition: false
has only substance units: false
type: Species
notes: FORMULA: C18H22O2 CHARGE: 0 INCHI: InChI=1S/C18H22O2/c1-18-9-8-14-13-5-3-12(19)10-11(13)2-4-15(14)16(18)6-7-17(18)20/h3,5,10,14-16,19H,2,4,6-9H2,1H3/t14-,15-,16+,18+/m1/s1 EHMN_ABBREVIATION: C00468
is: SBO:0000247
initial concentration: 1.0
initial amount: NaN
is: CHEBI:17263
name: estrone
constant: false
is: HMDB00145

metaR THRSERNaEx
modifier: MODEL1310110061#
product: MODEL1310110061#
reactant: MODEL1310110061#
notes: GENE_ASSOCIATION: (6509.1) or (6510.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14530974 NOTES:SAB see Kanai and Hediger 2004 (2003), PMID 14530974
fast: false
reversible: false
is: SBO:0000185
is described by: ECO:0000269
kinetic law: MODEL1310110061#
type: Reaction
name: L-serine/L-threonine Na-dependent exchange (Thr-L in)

metaM prostge2 e
initial concentration: 1.0
name: prostaglandin E2(1-)
boundary condition: false
initial amount: NaN
constant: false
is: CHEBI:606564
has only substance units: false
notes: FORMULA: C20H31O5 CHARGE: -1 INCHI: InChI=1S/C20H32O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h4,7,12-13,15-17,19,21,23H,2-3,5-6,8-11,14H2,1H3,(H,24,25)/p-1/b7-4-,13-12+/t15-,16+,17+,19+/m0/s1 EHMN_ABBREVIATION: C00584
is: HMDB01220
is: SBO:0000247
type: Species

metaR r2121
reactant: MODEL1310110061#
is: SBO:0000185
product: MODEL1310110061#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
modifier: MODEL1310110061#
fast: false
is described by: ECO:0000000
kinetic law: MODEL1310110061#
reversible: true
type: Reaction

metaR HAS1
reversible: false
modifier: MODEL1310110061#
product: MODEL1310110061#
is version of: http://identifiers.org/ec-code/2.4.1.212
type: Reaction
notes: GENE_ASSOCIATION: (3038.2) or (3036.1) or (3038.1) or (3037.1) SUBSYSTEM: Hyaluronan metabolism EC Number: 2.4.1.212 Confidence Level: 4 AUTHORS: PMID:12512858,PMID:8651928,PMID:8798477,PMID:8798544,PMID:9083017 NOTES:NCD
fast: false
is described by: ECO:0000269
name: hyaluronan synthase
kinetic law: MODEL1310110061#
reactant: MODEL1310110061#
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110061#_1ddd6c7c_2ab7_4230_9623_53b3504f55f3
type: Species
is encoded by: hsa:5238
has only substance units: false
constant: false
initial concentration: NaN
is: B4DX94
initial amount: NaN
name: PGM3
boundary condition: true
is: SBO:0000252

metaM cit m
is: CHEBI:16947
type: Species
constant: false
notes: FORMULA: C6H5O7 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00153 EHMN_ABBREVIATION: C00158
initial concentration: 1.0
has only substance units: false
is: C00158
is: HMDB00094
name: Citrate
initial amount: NaN
is: SBO:0000247
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110061#_f4d28399_4373_4c58_95c5_483263063ea6
is encoded by: hsa:1215
type: Species
initial amount: NaN
has only substance units: false
initial concentration: NaN
constant: false
is: SBO:0000252
boundary condition: true
name: CMA1
is: Q4FEB3

metaR LEUKTRB4t
kinetic law: MODEL1310110061#
reversible: true
is: SBO:0000185
reactant: MODEL1310110061#
type: Reaction
product: MODEL1310110061#
fast: false
name: leukotriene B4 transport
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110061#_04750255_4775_4c24_90b6_c93fd0f8dee7
is: SBO:0000252
name: PI4K2A
boundary condition: true
initial amount: NaN
is: Q9BTU6
has only substance units: false
type: Species
is encoded by: hsa:55361
initial concentration: NaN
constant: false

metaR BTNPLm
is version of: http://identifiers.org/ec-code/6.3.4.10
name: holocarboxylase synthestase (biotin protein ligase), mitochondrial
product: MODEL1310110061#
modifier: MODEL1310110061#
notes: GENE_ASSOCIATION: (3141.1) SUBSYSTEM: Biotin metabolism EC Number: Confidence Level: 4 AUTHORS: NOTES:IT for human biotin metabolism
is described by: ECO:0000000
kinetic law: MODEL1310110061#
reversible: false
is: SBO:0000176
type: Reaction
reactant: MODEL1310110061#
fast: false

http://identifiers.org/biomodels.db/MODEL1310110061#_38307949_87be_455f_96db_28127e993936
initial amount: NaN
is: SBO:0000252
constant: false
is encoded by: hsa:3098
is: Q59FD4
initial concentration: NaN
type: Species
boundary condition: true
name: HK1
has only substance units: false

metaM acnam l
has only substance units: false
constant: false
type: Species
initial amount: NaN
is: CHEBI:35418
name: N-acetylneuraminate
notes: FORMULA: C11H18NO9 CHARGE: -1 INCHI: InChI=1S/C11H19NO9/c1-4(14)12-7-5(15)2-11(20,10(18)19)21-9(7)8(17)6(16)3-13/h5-9,13,15-17,20H,2-3H2,1H3,(H,12,14)(H,18,19)/p-1/t5-,6+,7+,8+,9+,11?/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00244 EHMN_ABBREVIATION: C00270
is: HMDB00230
is: SBO:0000247
boundary condition: false
initial concentration: 1.0

metaM rib D c
initial amount: NaN
initial concentration: 1.0
is: HMDB00283
notes: FORMULA: C5H10O5 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00119
constant: false
name: D-ribose
is: CHEBI:16988
has only substance units: false
boundary condition: false
type: Species
is: SBO:0000247

metaR r1429
type: Reaction
kinetic law: MODEL1310110061#
product: MODEL1310110061#
reversible: true
is: SBO:0000185
reactant: MODEL1310110061#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 0 AUTHORS: PMID:17045662 NOTES:
name: Free diffusion
fast: false
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110061#_1aca89f4_7cb8_4740_bd14_5b0d06becb8a
initial amount: NaN
is: Q9UEF7
type: Species
name: KL
is encoded by: hsa:9365
has only substance units: false
initial concentration: NaN
boundary condition: true
is: SBO:0000252
constant: false

metaR EX pnto R LPAREN e RPAREN
kinetic law: MODEL1310110061#
reactant: MODEL1310110061#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: (R)-Pantothenate exchange
type: Reaction

metaM ura c
is: C00106
boundary condition: false
type: Species
name: Uracil
constant: false
notes: FORMULA: C4H4N2O2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00106 EHMN_ABBREVIATION: C00106
is: SBO:0000247
has only substance units: false
is: HMDB00300
is: CHEBI:17568
initial concentration: 1.0
initial amount: NaN

metaM hom L c
is: SBO:0000247
notes: FORMULA: C4H9NO3 CHARGE: 0 INCHI: InChI=1S/C4H9NO3/c5-3(1-2-6)4(7)8/h3,6H,1-2,5H2,(H,7,8)/t3-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00239
name: L-homoserine
is: CHEBI:15699
initial amount: NaN
boundary condition: false
type: Species
has only substance units: false
constant: false
initial concentration: 1.0
is: HMDB00719

http://identifiers.org/biomodels.db/MODEL1310110061#_d4193f2c_b284_41e6_947f_5e30ea2fb365
is: SBO:0000252
constant: false
type: Species
name: SLC38A1
boundary condition: true
has only substance units: false
initial amount: NaN
initial concentration: NaN
is: Q9H2H9
is encoded by: hsa:81539

metaR r0783
notes: GENE_ASSOCIATION: (1892.1) or (1962.1) or (3030.1) SUBSYSTEM: Cholesterol metabolism EC Number: 1.3.1.72 Confidence Level: 0 AUTHORS: PMID:7946524 NOTES:
product: MODEL1310110061#
is version of: http://identifiers.org/ec-code/4.2.1.17
type: Reaction
reversible: true
name: lanosterol D24-reductase Biosynthesis of steroids EC:1.3.1.72
fast: false
modifier: MODEL1310110061#
is version of: http://identifiers.org/ec-code/1.1.1.35
kinetic law: MODEL1310110061#
is: SBO:0000176
is described by: ECO:0000000
reactant: MODEL1310110061#

metaR r2120
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
type: Reaction
fast: false
reversible: true
product: MODEL1310110061#
kinetic law: MODEL1310110061#
is described by: ECO:0000000
is: SBO:0000185
modifier: MODEL1310110061#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
reactant: MODEL1310110061#

metaR r2090
modifier: MODEL1310110061#
reactant: MODEL1310110061#
is described by: ECO:0000000
product: MODEL1310110061#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
kinetic law: MODEL1310110061#
fast: false
reversible: true
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
is: SBO:0000185
type: Reaction

metaM dtmp m
has only substance units: false
is: C00364
is: CHEBI:26999
initial amount: NaN
boundary condition: false
initial concentration: 1.0
is: HMDB01227
type: Species
name: dTMP
is: SBO:0000247
notes: FORMULA: C10H13N2O8P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00308 EHMN_ABBREVIATION: C00364
constant: false

http://identifiers.org/biomodels.db/MODEL1310110061#_31a77d17_a4ec_4a4a_82e3_c153815610fe
is: SBO:0000252
boundary condition: true
type: Species
constant: false
initial concentration: NaN
is encoded by: hsa:5293
initial amount: NaN
is: A7E2E0
has only substance units: false
name: PIK3CD

metaR r1428
product: MODEL1310110061#
name: Free diffusion
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 0 AUTHORS: PMID:17045662 NOTES:
fast: false
is: SBO:0000185
is described by: ECO:0000000
kinetic law: MODEL1310110061#
type: Reaction
reactant: MODEL1310110061#

metaM rib D e
initial amount: NaN
boundary condition: false
is: SBO:0000247
type: Species
has only substance units: false
notes: FORMULA: C5H10O5 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00119
initial concentration: 1.0
is: CHEBI:16988
constant: false
is: HMDB00283
name: D-ribose

metaM 3sala c
initial amount: NaN
constant: false
notes: FORMULA: C3H5NO4S CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00451 EHMN_ABBREVIATION: C00606
is: SBO:0000247
type: Species
has only substance units: false
name: 3-Sulfino-L-alanine
is: C00606
initial concentration: 1.0
boundary condition: false
is: CHEBI:61085

metaR r2123
modifier: MODEL1310110061#
product: MODEL1310110061#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
fast: false
is described by: ECO:0000000
kinetic law: MODEL1310110061#
type: Reaction
reversible: true
is: SBO:0000185
reactant: MODEL1310110061#

metaM CE2056 r
has only substance units: false
initial concentration: 1.0
notes: FORMULA: C20H31O6 CHARGE: -1 INCHI: InChI=1/C20H32O6/c21-17(11-6-2-1-3-9-15-19(23)24)12-7-4-5-8-13-18(22)14-10-16-20(25)26/h2,4-8,12-13,17-19,21-24H,1,3,9-11,14-16H2,(H,25,26)/p-1/b5-4+,6-2-,12-7+,13-8-/t17-,18-/m0/s1 EHMN_ABBREVIATION: CE2056
type: Species
initial amount: NaN
boundary condition: false
constant: false
name: 20-dihydroxyleukotriene B4
is: SBO:0000247
is: HMDB01509
is: CHEBI:57460

metaR r2352
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
reversible: true
reactant: MODEL1310110061#
is described by: ECO:0000000
product: MODEL1310110061#
is: SBO:0000185
fast: false
name: Organic anion transporter 5 Utilized transport
type: Reaction
kinetic law: MODEL1310110061#

metaM tdcoa m
is: CHEBI:57385
boundary condition: false
type: Species
initial concentration: 1.0
constant: false
initial amount: NaN
has only substance units: false
is: C02593
is: SBO:0000247
is: HMDB01521
name: Tetradecanoyl-CoA (n-C14:0CoA)
notes: FORMULA: C35H58N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00971 EHMN_ABBREVIATION: C02593

metaM asn L m
constant: false
type: Species
name: L-asparagine
initial amount: NaN
is: HMDB00168
has only substance units: false
boundary condition: false
is: CHEBI:17196
notes: FORMULA: C4H8N2O3 CHARGE: 0 INCHI: InChI=1S/C4H8N2O3/c5-2(4(8)9)1-3(6)7/h2H,1,5H2,(H2,6,7)(H,8,9)/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00148
initial concentration: 1.0
is: SBO:0000247

metaM HC00682 m
type: Species
is: CHEBI:16807
has only substance units: false
initial concentration: 1.0
boundary condition: false
constant: false
name: S-Acetyldihydrolipoamide
is: SBO:0000247
initial amount: NaN
notes: FORMULA: C10H19NO2S2 CHARGE: 0 INCHI: InChI=1S/C10H19NO2S2/c1-8(12)15-9(6-7-14)4-2-3-5-10(11)13/h9,14H,2-7H2,1H3,(H2,11,13) EHMN_ABBREVIATION: C01136

http://identifiers.org/biomodels.db/MODEL1310110061#_2eb251a8_e21b_4ac5_a079_79c83ca3e8dc
type: Species
initial amount: NaN
boundary condition: true
constant: false
is: SBO:0000252
initial concentration: NaN
has only substance units: false
is encoded by: hsa:U37519
name: _U37519_1_c

metaR SMPD3g
product: MODEL1310110061#
is version of: http://identifiers.org/ec-code/3.1.4.12
fast: false
name: sphingomyelin phosphodiesterase 3, neutral membrane (neutral sphingomyelinase II)
modifier: MODEL1310110061#
type: Reaction
notes: GENE_ASSOCIATION: (55512.1) or (55512.2) SUBSYSTEM: Sphingolipid metabolism EC Number: Confidence Level: 2 AUTHORS: NOTES:NJ
is: SBO:0000176
is described by: ECO:0000304
reactant: MODEL1310110061#
kinetic law: MODEL1310110061#
reversible: false

metaR PHEACGLNt
name: PHEACGLN extracellular transport via diffusion
product: MODEL1310110061#
reversible: true
is: SBO:0000185
is described by: ECO:0000000
kinetic law: MODEL1310110061#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14681857 NOTES:SAB
type: Reaction
reactant: MODEL1310110061#
fast: false

metaR r0784
fast: false
product: MODEL1310110061#
name: xylitol:NAD oxidoreductase Pentose and glucuronate interconversions EC:1.1.1.15
type: Reaction
is version of: http://identifiers.org/ec-code/1.3.1.38
reversible: true
kinetic law: MODEL1310110061#
is: SBO:0000176
is described by: ECO:0000000
reactant: MODEL1310110061#
notes: GENE_ASSOCIATION: (AA526438.1) or (H17063.1) or (51102.1) or (55825.1) SUBSYSTEM: Pentose phosphate pathway EC Number: 1.1.1.15 Confidence Level: 0 AUTHORS: PMID:13373783 NOTES:
modifier: MODEL1310110061#

metaM lnlc c
is: HMDB00673
is: CHEBI:30245
boundary condition: false
initial concentration: 1.0
has only substance units: false
constant: false
is: SBO:0000247
initial amount: NaN
name: linoleate
notes: FORMULA: C18H31O2 CHARGE: -1 INCHI: InChI=1S/C18H32O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20/h6-7,9-10H,2-5,8,11-17H2,1H3,(H,19,20)/p-1/b7-6-,10-9-
type: Species

http://identifiers.org/biomodels.db/MODEL1310110061#_f1673780_34c6_4e78_907c_f9bd82ef6a8d
is: Q9UMR5
constant: false
is: SBO:0000252
initial concentration: NaN
initial amount: NaN
has only substance units: false
name: PPT2
type: Species
is encoded by: hsa:9374
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110061#_4c8b0c5d_07a5_496a_b57d_3d9fbc13c521
initial concentration: NaN
has only substance units: false
constant: false
is: Q9NY59
is: SBO:0000252
is encoded by: hsa:55512
type: Species
name: SMPD3
initial amount: NaN
boundary condition: true

metaR r1949
fast: false
reversible: false
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
type: Reaction
name: Y+LAT2 Utilized transport
product: MODEL1310110061#
is: SBO:0000185
reactant: MODEL1310110061#
modifier: MODEL1310110061#
kinetic law: MODEL1310110061#

http://identifiers.org/biomodels.db/MODEL1310110061#_06eeb790_4ffa_4f04_bf80_c145b8e673e5
is: SBO:0000252
initial concentration: NaN
has only substance units: false
name: PLCB3
boundary condition: true
type: Species
is encoded by: hsa:5331
initial amount: NaN
constant: false
is: G5E960

http://identifiers.org/biomodels.db/MODEL1310110061#_17fa3f2e_1d72_4453_a391_f3f8c5ae0a0a
is: P30838
initial amount: NaN
is encoded by: hsa:218
has only substance units: false
is: SBO:0000252
name: ALDH3A1
boundary condition: true
constant: false
type: Species
initial concentration: NaN

metaM lnlccoa m
boundary condition: false
is: http://identifiers.org/pubchem.compound/5462164
has only substance units: false
initial amount: NaN
type: Species
notes: FORMULA: C39H62N7O17P3S CHARGE: -4 INCHI: InChI=1/C39H66N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-30(48)67-23-22-41-29(47)20-21-42-37(51)34(50)39(2,3)25-60-66(57,58)63-65(55,56)59-24-28-33(62-64(52,53)54)32(49)38(61-28)46-27-45-31-35(40)43-26-44-36(31)46/h8-9,11-12,26-28,32-34,38,49-50H,4-7,10,13-25H2,1-3H3,(H,41,47)(H,42,51)(H,55,56)(H,57,58)(H2,40,43,44)(H2,52,53,54)/b9-8+,12-11+ HEPATONET_1.0_ABBREVIATION: HC01983
is: HMDB01064
name: linoleic coenzyme A
constant: false
is: SBO:0000247
initial concentration: 1.0

metaR r2122
product: MODEL1310110061#
is: SBO:0000185
kinetic law: MODEL1310110061#
is described by: ECO:0000000
modifier: MODEL1310110061#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
reversible: true
type: Reaction
fast: false
reactant: MODEL1310110061#

http://identifiers.org/biomodels.db/MODEL1310110061#_763e4c83_88f4_4e71_be51_bbbfa9e99dcb
is encoded by: hsa:2731
is encoded by: hsa:275
has part: P23378
has only substance units: false
has part: P48728
boundary condition: true
constant: false
name: DLD:GCSH:GLDC:AMT
is: SBO:0000297
type: Species
has part: P23434
is encoded by: hsa:2653
initial amount: NaN
initial concentration: NaN

metaR EX pheacgln LPAREN e RPAREN
kinetic law: MODEL1310110061#
reactant: MODEL1310110061#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: alpha-N-Phenylacetyl-L-glutamine exchange
type: Reaction

metaR r2353
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
fast: false
name: Organic anion transporter 5 Utilized transport
reversible: true
reactant: MODEL1310110061#
is described by: ECO:0000000
product: MODEL1310110061#
type: Reaction
kinetic law: MODEL1310110061#

metaM hom L e
initial amount: NaN
is: CHEBI:15699
notes: FORMULA: C4H9NO3 CHARGE: 0 INCHI: InChI=1S/C4H9NO3/c5-3(1-2-6)4(7)8/h3,6H,1-2,5H2,(H,7,8)/t3-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00239
has only substance units: false
is: HMDB00719
is: SBO:0000247
type: Species
initial concentration: 1.0
boundary condition: false
name: L-homoserine
constant: false

metaM 4abut e
is: C00334
has only substance units: false
is: CHEBI:3628
boundary condition: false
is: SBO:0000247
notes: FORMULA: C4H9NO2 CHARGE: 0
is: HMDB00112
type: Species
initial amount: NaN
constant: false
initial concentration: 1.0
name: 4-Aminobutanoate

metaM ura e
is: CHEBI:17568
has only substance units: false
name: uracil
type: Species
constant: false
notes: FORMULA: C4H4N2O2 CHARGE: 0 INCHI: InChI=1S/C4H4N2O2/c7-3-1-2-5-4(8)6-3/h1-2H,(H2,5,6,7,8) HEPATONET_1.0_ABBREVIATION: HC00106 EHMN_ABBREVIATION: C00106
is: SBO:0000247
initial amount: NaN
boundary condition: false
is: HMDB00300
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110061#_de68bd2a_0743_4cfd_a836_72f4209ff41d
has only substance units: false
initial concentration: NaN
boundary condition: true
type: Species
is: Q6I9V5
is: SBO:0000252
constant: false
initial amount: NaN
name: SLC25A6
is encoded by: hsa:293

metaM 2docopencoa m
is: HMDB02288
initial amount: NaN
is: SBO:0000247
type: Species
has only substance units: false
initial concentration: 1.0
constant: false
notes: FORMULA: C43H64N7O17P3S CHARGE: -4
name: 2,7,10,13,16-docosapentenoylcoa
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110061#_4edd7b83_5809_4486_8cca_cddb4acfd3fc
has only substance units: false
name: _AA419122_1_c
boundary condition: true
is: SBO:0000252
initial amount: NaN
type: Species
initial concentration: NaN
constant: false
is encoded by: hsa:AA419122

http://identifiers.org/biomodels.db/MODEL1310110061#_7fb76fb0_fef0_48b2_bce1_2effa279c486
boundary condition: true
type: Species
is encoded by: hsa:493
is: P23634
initial concentration: NaN
name: ATP2B4
has only substance units: false
is: SBO:0000252
initial amount: NaN
constant: false

metaR r2354
type: Reaction
kinetic law: MODEL1310110061#
name: Organic anion transporter 5 Utilized transport
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
reversible: true
reactant: MODEL1310110061#
is: SBO:0000185
is described by: ECO:0000000
fast: false
product: MODEL1310110061#

metaR SERDGLNexR
fast: false
reactant: MODEL1310110061#
notes: GENE_ASSOCIATION: (56301.1) and (6520.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10734121,PMID:10863037,PMID:14770310 NOTES:
product: MODEL1310110061#
kinetic law: MODEL1310110061#
is: SBO:0000185
is described by: ECO:0000304
modifier: MODEL1310110061#
name: D-Serine/Glutamine reversible exchange
type: Reaction
reversible: true

metaR r2125
product: MODEL1310110061#
reversible: true
is described by: ECO:0000000
kinetic law: MODEL1310110061#
is: SBO:0000185
fast: false
type: Reaction
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
modifier: MODEL1310110061#
reactant: MODEL1310110061#

metaM CE0785 m
name: cis,cis-myristo-5,8-dienoyl-CoA
type: Species
initial concentration: 1.0
boundary condition: false
is: CHEBI:57795
constant: false
initial amount: NaN
has only substance units: false
notes: FORMULA: C35H54N7O17P3S CHARGE: -4 INCHI: InChI=1/C35H58N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-26(44)63-19-18-37-25(43)16-17-38-33(47)30(46)35(2,3)21-56-62(53,54)59-61(51,52)55-20-24-29(58-60(48,49)50)28(45)34(57-24)42-23-41-27-31(36)39-22-40-32(27)42/h8-9,11-12,22-24,28-30,34,45-46H,4-7,10,13-21H2,1-3H3,(H,37,43)(H,38,47)(H,51,52)(H,53,54)(H2,36,39,40)(H2,48,49,50)/p-4/b9-8-,12-11-/t24-,28+,29+,30u,34-/m0/s1 EHMN_ABBREVIATION: CE0785
is: SBO:0000247

metaR EX o2s LPAREN e RPAREN
kinetic law: MODEL1310110061#
reactant: MODEL1310110061#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Superoxide anion exchange
type: Reaction

metaR DNDPt35m
is described by: ECO:0000269
is: SBO:0000185
product: MODEL1310110061#
notes: GENE_ASSOCIATION: (60386.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:11226231 NOTES:IT
reactant: MODEL1310110061#
type: Reaction
name: dGDP transport via dADP antiport
reversible: false
modifier: MODEL1310110061#
fast: false
kinetic law: MODEL1310110061#

metaM acgam c
initial concentration: 1.0
has only substance units: false
is: CHEBI:17411
is: SBO:0000247
constant: false
initial amount: NaN
boundary condition: false
notes: FORMULA: C8H15NO6 CHARGE: 0 INCHI: InChI=1S/C8H15NO6/c1-4(12)9-5(2-10)7(14)8(15)6(13)3-11/h2,5-8,11,13-15H,3H2,1H3,(H,9,12)/t5-,6+,7+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00138 EHMN_ABBREVIATION: C00140
type: Species
is: HMDB00215
name: N-acetyl-D-glucosamine

metaR RE0577C
is version of: http://identifiers.org/ec-code/2.3.1.65
is described by: ECO:0000000
name: RE0577
product: MODEL1310110061#
modifier: MODEL1310110061#
is version of: http://identifiers.org/ec-code/3.1.2.2
type: Reaction
fast: false
reactant: MODEL1310110061#
kinetic law: MODEL1310110061#
reversible: true
notes: GENE_ASSOCIATION: (641372.1) or (641371.1) or (570.1) SUBSYSTEM: Fatty acid synthesis EC Number: 3.1.2.2 Confidence Level: 0 AUTHORS: PMID:10092594,PMID:10578051,PMID:16103133,PMID:16940157,PMID:9153233 NOTES:
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110061#_fc6bd82f_786f_4ae9_9e4b_f24fe77c81f4
has only substance units: false
is: SBO:0000252
is: P28330
initial amount: NaN
boundary condition: true
initial concentration: NaN
name: ACADL
type: Species
constant: false
is encoded by: hsa:33

metaR ASNGLNNaEx
fast: false
type: Reaction
product: MODEL1310110061#
reactant: MODEL1310110061#
reversible: false
modifier: MODEL1310110061#
is described by: ECO:0000269
is: SBO:0000185
kinetic law: MODEL1310110061#
name: L-glutamine/L-asparagine Na-dependent exchange (Asn-L in)
notes: GENE_ASSOCIATION: (6510.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14530974 NOTES:SAB see Kanai and Hediger 2004 (2003), PMID 14530974

metaR r2355
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
reversible: true
reactant: MODEL1310110061#
name: Organic anion transporter 5 Utilized transport
is described by: ECO:0000000
product: MODEL1310110061#
type: Reaction
kinetic law: MODEL1310110061#
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110061#_9cb2c1e0_05fd_406e_9933_ed4a30968730
is: SBO:0000252
is encoded by: hsa:37
initial amount: NaN
name: ACADVL
boundary condition: true
initial concentration: NaN
constant: false
has only substance units: false
is: P49748
type: Species

metaR UDPGLCAter
kinetic law: MODEL1310110061#
reactant: MODEL1310110061#
modifier: MODEL1310110061#
notes: GENE_ASSOCIATION: (23169.1) SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 4 AUTHORS: PMID:11322953 NOTES:NCD
name: UDPGlcA endoplasmic reticulum transport via UMP antiport
is described by: ECO:0000269
reversible: true
is: SBO:0000185
type: Reaction
product: MODEL1310110061#
fast: false

http://identifiers.org/biomodels.db/MODEL1310110061#_6d492f0f_4a80_4a79_835c_c7f6030ebc98
is: P14555
boundary condition: true
has only substance units: false
type: Species
is: SBO:0000252
name: PLA2G2A
is encoded by: hsa:5320
initial concentration: NaN
initial amount: NaN
constant: false

metaM 4abut c
name: 4-Aminobutanoate
is: C00334
boundary condition: false
type: Species
has only substance units: false
constant: false
initial concentration: 1.0
notes: FORMULA: C4H9NO2 CHARGE: 0
is: HMDB00112
is: CHEBI:3628
initial amount: NaN
is: SBO:0000247

metaR r2124
is: SBO:0000185
product: MODEL1310110061#
kinetic law: MODEL1310110061#
is described by: ECO:0000000
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
modifier: MODEL1310110061#
reversible: true
fast: false
type: Reaction
reactant: MODEL1310110061#

http://identifiers.org/biomodels.db/MODEL1310110061#_be2e8c89_d257_4cd4_8ac1_aef2f899f355
has only substance units: false
is encoded by: hsa:51727
is: B2R6S5
constant: false
initial concentration: NaN
type: Species
boundary condition: true
initial amount: NaN
name: CMPK1
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110061#_4d6559e3_77d0_495b_8d5c_8218f1eec125
initial amount: NaN
type: Species
is encoded by: hsa:1737
is: SBO:0000252
constant: false
is: Q86YI5
name: DLAT
initial concentration: NaN
boundary condition: true
has only substance units: false

metaR H2CO3D
fast: false
notes: GENE_ASSOCIATION: (761.1) or (771.1) or (377677.1) or (762.1) or (766.2) or (23632.1) or (766.1) or (771.2) or (759.1) or (768.1) or (760.1) SUBSYSTEM: Miscellaneous EC Number: 4.2.1.1 Confidence Level: 0 AUTHORS: PMID:11101628,PMID:11172051,PMID:11676494,PMID:14600151,PMID:7574487 NOTES:tv
is described by: ECO:0000000
type: Reaction
product: MODEL1310110061#
reactant: MODEL1310110061#
modifier: MODEL1310110061#
name: carboxylic acid dissociation
is: SBO:0000176
kinetic law: MODEL1310110061#
is version of: http://identifiers.org/ec-code/4.2.1.1
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110061#_4249b741_0646_4f66_aba7_290b60bd2e8d
is: SBO:0000252
type: Species
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:AA576959
constant: false
name: _AA576959_1_c
boundary condition: true
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110061#_0ec4b383_0e2f_4845_960c_72a8ba70ca98
boundary condition: true
initial concentration: NaN
constant: false
is encoded by: hsa:5198
has only substance units: false
is: SBO:0000252
is: Q6P4B4
type: Species
initial amount: NaN
name: PFAS

metaR 3SPYRSPm
name: 3-sulfinopyruvate hydrolase (spotaneous reaction), mitochondrial
fast: false
reversible: false
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Methionine and cysteine metabolism EC Number: Confidence Level: 2 AUTHORS: PMID:3346220 NOTES:MM
is: SBO:0000176
product: MODEL1310110061#
type: Reaction
kinetic law: MODEL1310110061#
reactant: MODEL1310110061#

metaR PGMT
kinetic law: MODEL1310110061#
product: MODEL1310110061#
type: Reaction
is described by: ECO:0000134
name: phosphoglucomutase
is version of: http://identifiers.org/ec-code/5.4.2.2
is: SBO:0000176
fast: false
modifier: MODEL1310110061#
reactant: MODEL1310110061#
notes: GENE_ASSOCIATION: (5236.1) or (55276.1) SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: 5.4.2.2 Confidence Level: 0 AUTHORS: PMID:4829444 NOTES:
reversible: true

metaM r5p c
constant: false
name: alpha-D-Ribose 5-phosphate
is: CHEBI:18189
initial amount: NaN
notes: FORMULA: C5H9O8P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00115 EHMN_ABBREVIATION: C00117
is: HMDB00618
type: Species
has only substance units: false
is: SBO:0000247
is: C00117
initial concentration: 1.0
boundary condition: false

metaR r0787
product: MODEL1310110061#
is version of: http://identifiers.org/ec-code/1.1.1.1
kinetic law: MODEL1310110061#
fast: false
reversible: false
modifier: MODEL1310110061#
type: Reaction
name: 3-sn-phosphatidate phosphohydrolase Sphingolipid metabolism EC:3.1.3.4
reactant: MODEL1310110061#
is: SBO:0000176
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (124.1) or (125.1) or (128.1) or (130.1) or (131.1) or (AI291895.1) or (M68895.1) or (X63359.1) SUBSYSTEM: Sphingolipid metabolism EC Number: 3.1.3.4 Confidence Level: 0 AUTHORS: PMID:7575445 NOTES:

metaR CITL
name: Citrate lyase
reactant: MODEL1310110061#
reversible: false
kinetic law: MODEL1310110061#
product: MODEL1310110061#
fast: false
type: Reaction
is: SBO:0000176
modifier: MODEL1310110061#
notes: GENE_ASSOCIATION: (171425.1) or (171425.2) SUBSYSTEM: Citric acid cycle EC Number: 4.1.3.6 Confidence Level: 0 AUTHORS: PMID:11741334 NOTES:JLR
is described by: ECO:0000000

metaR 4HBZCOAFm
reactant: MODEL1310110061#
name: 4-hydroxybenzoyl-CoA formation
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Ubiquinone synthesis EC Number: Confidence Level: 2 AUTHORS: PMID:11583838,PMID:12232327 NOTES:IT reaction involved in formation of 4-hydroxybenzoate from tyrosine.
is: SBO:0000176
type: Reaction
is described by: ECO:0000000
product: MODEL1310110061#
reversible: false
kinetic law: MODEL1310110061#

http://identifiers.org/biomodels.db/MODEL1310110061#_e3b068bd_a3ba_4e89_a7b4_fcea8b7e3a6f
initial amount: NaN
is encoded by: hsa:314
boundary condition: true
initial concentration: NaN
constant: false
has only substance units: false
type: Species
is: SBO:0000252
name: AOC2

metaR r2356
kinetic law: MODEL1310110061#
reversible: true
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
is: SBO:0000185
reactant: MODEL1310110061#
is described by: ECO:0000000
product: MODEL1310110061#
name: Organic anion transporter 5 Utilized transport
type: Reaction

metaR TYRt
type: Reaction
fast: false
name: L-tyrosine transport
notes: GENE_ASSOCIATION: (117247.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:11827462 NOTES:
product: MODEL1310110061#
reversible: true
modifier: MODEL1310110061#
is: SBO:0000185
kinetic law: MODEL1310110061#
reactant: MODEL1310110061#
is described by: ECO:0000269

metaR r2127
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
product: MODEL1310110061#
is described by: ECO:0000000
reversible: true
is: SBO:0000185
type: Reaction
fast: false
kinetic law: MODEL1310110061#
reactant: MODEL1310110061#
modifier: MODEL1310110061#

metaM HC01444 e
initial amount: NaN
is: CHEBI:15754
boundary condition: false
has only substance units: false
is: SBO:0000247
name: Galactosylglycerol
initial concentration: 1.0
type: Species
constant: false
notes: FORMULA: C9H18O8 CHARGE: 0 INCHI: InChI=1S/C9H18O8/c10-1-4(12)3-16-9-8(15)7(14)6(13)5(2-11)17-9/h4-15H,1-3H2/t4-,5-,6+,7+,8-,9-/m1/s1 EHMN_ABBREVIATION: C05401

metaM 4abutn m
type: Species
initial concentration: 1.0
name: 4-ammoniobutanal
constant: false
has only substance units: false
initial amount: NaN
notes: FORMULA: C4H10NO CHARGE: 1 INCHI: InChI=1S/C4H9NO/c5-3-1-2-4-6/h4H,1-3,5H2/p+1 HEPATONET_1.0_ABBREVIATION: HC00428 EHMN_ABBREVIATION: C00555
is: SBO:0000247
is: HMDB01080
boundary condition: false
is: CHEBI:58264

metaR TCHOLAte
product: MODEL1310110061#
fast: false
is: SBO:0000185
name: bile acid intracellular transport
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:unknown mechanism, however bile acids need to be secreted out of the cell NJ
kinetic law: MODEL1310110061#
type: Reaction
reversible: true
reactant: MODEL1310110061#

metaR PRO Dtde
reversible: true
is: SBO:0000185
product: MODEL1310110061#
kinetic law: MODEL1310110061#
is described by: ECO:0000134
fast: false
name: D-proline transport, extracellular
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 1 AUTHORS: added during gap-filling. Diffusion into the blood is assumed. NOTES:added during gap-filling. Diffusion into the blood is assumed.
reactant: MODEL1310110061#

metaR r1640
is: SBO:0000185
reactant: MODEL1310110061#
is described by: ECO:0000000
product: MODEL1310110061#
modifier: MODEL1310110061#
reversible: true
type: Reaction
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
fast: false
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
kinetic law: MODEL1310110061#

metaR ALAR
notes: GENE_ASSOCIATION: (11212.1) SUBSYSTEM: Alanine and aspartate metabolism EC Number: 5.1.1.1 Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000212
product: MODEL1310110061#
type: Reaction
fast: false
is: SBO:0000176
reactant: MODEL1310110061#
name: alanine racemase
modifier: MODEL1310110061#
kinetic law: MODEL1310110061#
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110061#_21925a22_9e9d_4985_aa77_efa5d4dfdc83
initial amount: NaN
constant: false
type: Species
initial concentration: NaN
boundary condition: true
has only substance units: false
is: O75355
is encoded by: hsa:956
is: SBO:0000252
name: ENTPD3

metaM lneldccrn c
constant: false
is: SBO:0000247
initial amount: NaN
initial concentration: 1.0
type: Species
has only substance units: false
boundary condition: false
name: Linoelaidyl carnitine
notes: FORMULA: C25H45NO4 CHARGE: 0 INCHI: InChI=1/C25H45NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-25(29)30-23(21-24(27)28)22-26(2,3)4/h9-10,12-13,23H,5-8,11,14-22H2,1-4H3/b10-9+,13-12+
is: HMDB06461

metaR r0788
reversible: true
type: Reaction
notes: GENE_ASSOCIATION: (1593.1) SUBSYSTEM: Sphingolipid metabolism EC Number: 2.1.1.103 Confidence Level: 0 AUTHORS: PMID:2403362 NOTES:
name: S-Adenosyl-L-methionine:methylethanolamine phosphate N-methyltransferase Glycerophospholipid metabolism EC:2.1.1.103
fast: false
modifier: MODEL1310110061#
is: SBO:0000176
reactant: MODEL1310110061#
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/1.14.13.15
product: MODEL1310110061#
kinetic law: MODEL1310110061#

metaR MGSA
is: SBO:0000176
reversible: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Pyruvate metabolism EC Number: 4.2.3.3 Confidence Level: 4 AUTHORS: PMID:1537826,PMID:16037240,PMID:8853285 NOTES:Previously EC 4.2.99.11 this rxn represents the enzymatic conversion or non-enzymatic fragmentation of dhap to mthgxl - NCD
name: methylglyoxal synthase
is described by: ECO:0000000
kinetic law: MODEL1310110061#
fast: false
reactant: MODEL1310110061#
product: MODEL1310110061#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110061#_ab997157_bd3a_4936_a8e4_d1ed049e9004
is: E7EPT3
name: ALDH7A1
initial concentration: NaN
initial amount: NaN
has only substance units: false
type: Species
constant: false
is: SBO:0000252
boundary condition: true
is encoded by: hsa:501

metaR r1570
product: MODEL1310110061#
reactant: MODEL1310110061#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
kinetic law: MODEL1310110061#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reversible: true
type: Reaction
is described by: ECO:0000000
is: SBO:0000185

metaR r0193
is described by: ECO:0000000
reversible: true
reactant: MODEL1310110061#
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Cysteine Metabolism EC Number: 4.4.1.1 Confidence Level: 0 AUTHORS: PMID:10212249,PMID:629532 NOTES:
kinetic law: MODEL1310110061#
name: L-Cysteine L-homocysteine-lyase (deaminating) Cysteine metabolism EC:4.4.1.1
fast: false
type: Reaction
product: MODEL1310110061#

metaR EX srtn LPAREN e RPAREN
kinetic law: MODEL1310110061#
reactant: MODEL1310110061#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Serotonin exchange
type: Reaction

metaR GALASE16ly
is version of: http://identifiers.org/ec-code/3.2.1.23
modifier: MODEL1310110061#
is version of: http://identifiers.org/ec-code/3.1.6.4
type: Reaction
is: SBO:0000176
reversible: false
name: beta-galactosidase, lysosomal
is version of: http://identifiers.org/ec-code/3.4.16.5
is version of: http://identifiers.org/ec-code/3.2.1.18
reactant: MODEL1310110061#
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) or (5476.1) and (2720.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.23 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD
is described by: ECO:0000000
product: MODEL1310110061#
kinetic law: MODEL1310110061#
fast: false

metaM hmgcoa m
has only substance units: false
boundary condition: false
name: Hydroxymethylglutaryl-CoA
is: CHEBI:15467
initial amount: NaN
constant: false
notes: FORMULA: C27H39N7O20P3S CHARGE: -5 INCHI: InChI=1S/C27H44N7O20P3S/c1-26(2,21(40)24(41)30-5-4-15(35)29-6-7-58-17(38)9-27(3,42)8-16(36)37)11-51-57(48,49)54-56(46,47)50-10-14-20(53-55(43,44)45)19(39)25(52-14)34-13-33-18-22(28)31-12-32-23(18)34/h12-14,19-21,25,39-40,42H,4-11H2,1-3H3,(H,29,35)(H,30,41)(H,36,37)(H,46,47)(H,48,49)(H2,28,31,32)(H2,43,44,45)/t14-,19-,20-,21+,25-,27+/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00302 EHMN_ABBREVIATION: C00356
is: SBO:0000247
is: HMDB01375
initial concentration: 1.0
type: Species

metaM 5htrp c
is: CHEBI:17780
boundary condition: false
notes: FORMULA: C11H12N2O3 CHARGE: 0 INCHI: InChI=1S/C11H12N2O3/c12-9(11(15)16)3-6-5-13-10-2-1-7(14)4-8(6)10/h1-2,4-5,9,13-14H,3,12H2,(H,15,16)/t9-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00472 EHMN_ABBREVIATION: C00643
type: Species
constant: false
has only substance units: false
name: 5-hydroxy-L-tryptophan
is: HMDB00472
is: SBO:0000247
initial concentration: 1.0
initial amount: NaN

metaR ACSm
is described by: ECO:0000304
reactant: MODEL1310110061#
is version of: http://identifiers.org/ec-code/6.2.1.1
product: MODEL1310110061#
type: Reaction
kinetic law: MODEL1310110061#
notes: GENE_ASSOCIATION: (84532.1) SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: 6.2.1.1 Confidence Level: 2 AUTHORS: PMID:11150295,PMID:4326157 NOTES:IF
is: SBO:0000176
name: acetyl-CoA synthetase
fast: false
modifier: MODEL1310110061#
reversible: false

metaR r2357
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
name: Organic anion transporter 5 Utilized transport
reactant: MODEL1310110061#
is described by: ECO:0000000
product: MODEL1310110061#
fast: false
type: Reaction
is: SBO:0000185
kinetic law: MODEL1310110061#
reversible: true

metaR NADPHtru
kinetic law: MODEL1310110061#
reactant: MODEL1310110061#
name: NADPH transporter, endoplasmic reticulum
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: NOTES:diffusion - but unidirectional uptake into ER (to avoid loops w/ NAD/NADP) NJ
reversible: false
product: MODEL1310110061#
fast: false
is: SBO:0000185
is described by: ECO:0000000

metaM dadp c
is: C00206
boundary condition: false
initial concentration: 1.0
is: CHEBI:57667
constant: false
type: Species
is: HMDB01508
has only substance units: false
notes: FORMULA: C10H12N5O9P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00192 EHMN_ABBREVIATION: C00206
is: SBO:0000247
initial amount: NaN
name: dADP

metaM dcacoa m
notes: FORMULA: C31H50N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC01413 EHMN_ABBREVIATION: C05274
initial amount: NaN
name: Decanoyl-CoA (n-C10:0CoA)
is: C05274
boundary condition: false
is: HMDB06404
constant: false
type: Species
is: CHEBI:61430
initial concentration: 1.0
has only substance units: false
is: SBO:0000247

metaR r2126
modifier: MODEL1310110061#
fast: false
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
reversible: true
is described by: ECO:0000000
kinetic law: MODEL1310110061#
type: Reaction
reactant: MODEL1310110061#
product: MODEL1310110061#
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110061#_25c37fb0_93e7_482f_84ea_a54806b14c59
initial amount: NaN
constant: false
is: SBO:0000252
has only substance units: false
initial concentration: NaN
name: DGKB
type: Species
boundary condition: true
is encoded by: hsa:1607

metaR r1423
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: 4.2.1.1 Confidence Level: 0 AUTHORS: PMID:10938543,PMID:11493685,PMID:12713833,PMID:12747791,PMID:14640555,PMID:17259996,PMID:17504134,PMID:17826101,PMID:7011879,PMID:7672338 NOTES:
type: Reaction
reversible: false
reactant: MODEL1310110061#
product: MODEL1310110061#
name: Facilitated diffusion
kinetic law: MODEL1310110061#
fast: false
is: SBO:0000185

metaR DESAT22 2p
name: fatty acyl-CoA desaturase (n-C22:5CoA -> n-C22:6CoA)
reactant: MODEL1310110061#
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid synthesis EC Number: 1.14.19.1 Confidence Level: 4 AUTHORS: NOTES:
is: SBO:0000176
fast: false
product: MODEL1310110061#
is described by: ECO:0000000
type: Reaction
kinetic law: MODEL1310110061#
reversible: false

metaR r1571
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reversible: true
reactant: MODEL1310110061#
fast: false
is: SBO:0000185
kinetic law: MODEL1310110061#
type: Reaction
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
product: MODEL1310110061#

metaR GLCSGLT1le
kinetic law: MODEL1310110061#
product: MODEL1310110061#
reactant: MODEL1310110061#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of D-glucose from extracellular space to cytosol of mucosal cells in small intestine
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110061#_2988e9f3_d738_44dd_baae_8be1d8dc5e1c
is encoded by: hsa:26279
has only substance units: false
name: PLA2G2D
is: Q9UNK4
boundary condition: true
initial amount: NaN
initial concentration: NaN
is: SBO:0000252
type: Species
constant: false

metaM fad e
notes: FORMULA: C27H31N9O15P2 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00026 EHMN_ABBREVIATION: C00016
constant: false
initial amount: NaN
name: Flavin adenine dinucleotide oxidized
is: HMDB01248
type: Species
is: CHEBI:16238
initial concentration: 1.0
is: SBO:0000247
has only substance units: false
boundary condition: false
is: C00016

metaR FAOXC61m
kinetic law: MODEL1310110061#
product: MODEL1310110061#
reactant: MODEL1310110061#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: isomerization(C6:1)m
type: Reaction

metaR RE3050R
notes: GENE_ASSOCIATION: SUBSYSTEM: Vitamin A metabolism EC Number: 1.2.1.36 Confidence Level: 0 AUTHORS: PMID:10559215 NOTES:
type: Reaction
fast: false
product: MODEL1310110061#
name: RE3050
is described by: ECO:0000000
kinetic law: MODEL1310110061#
reversible: true
is: SBO:0000176
reactant: MODEL1310110061#

metaR RE1342C
product: MODEL1310110061#
is: SBO:0000176
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Fructose and mannose metabolism EC Number: 1.1.1.21 Confidence Level: 0 AUTHORS: PMID:9537432 NOTES:IT - fixed proton
kinetic law: MODEL1310110061#
is described by: ECO:0000000
reactant: MODEL1310110061#
type: Reaction
reversible: true
name: RE1342

metaR r0789
fast: false
product: MODEL1310110061#
kinetic law: MODEL1310110061#
notes: GENE_ASSOCIATION: (1593.1) SUBSYSTEM: Sphingolipid metabolism EC Number: 2.1.1.103 Confidence Level: 0 AUTHORS: PMID:2403362 NOTES:
type: Reaction
reversible: true
modifier: MODEL1310110061#
is version of: http://identifiers.org/ec-code/1.14.13.15
is: SBO:0000176
name: S-Adenosyl-L-methionine:phosphodimethylethanolamine N-methyltransferase Glycerophospholipid metabolism EC:2.1.1.103
reactant: MODEL1310110061#
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110061#_6a36ec02_16f2_4dbd_bae9_0e4b5b5e81d4
is: SBO:0000252
type: Species
name: MTMR3
initial concentration: NaN
has only substance units: false
initial amount: NaN
boundary condition: true
is encoded by: hsa:8897
constant: false
is: Q13615

metaR r0706
is described by: ECO:0000000
is: SBO:0000176
reversible: false
modifier: MODEL1310110061#
name: acyl-Coenzyme A dehydrogenase family, member 9 Bile acid biosynthesis EC:1.3.3.6
reactant: MODEL1310110061#
kinetic law: MODEL1310110061#
is version of: http://identifiers.org/ec-code/1.3.99.3
type: Reaction
fast: false
product: MODEL1310110061#
is version of: http://identifiers.org/ec-code/1.3.99.10
notes: GENE_ASSOCIATION: (34.1) or (3712.1) or (R14373.1) SUBSYSTEM: Bile acid synthesis EC Number: 1.3.3.6 Confidence Level: 0 AUTHORS: PMID:11356170,PMID:8943006 NOTES:RE1814X

metaM HC01410 m
type: Species
is: CHEBI:28706
constant: false
is: SBO:0000247
has only substance units: false
initial concentration: 1.0
notes: FORMULA: C27H40N7O17P3S CHARGE: -4 INCHI: InChI=1S/C27H44N7O17P3S/c1-4-5-6-7-18(36)55-11-10-29-17(35)8-9-30-25(39)22(38)27(2,3)13-48-54(45,46)51-53(43,44)47-12-16-21(50-52(40,41)42)20(37)26(49-16)34-15-33-19-23(28)31-14-32-24(19)34/h6-7,14-16,20-22,26,37-38H,4-5,8-13H2,1-3H3,(H,29,35)(H,30,39)(H,43,44)(H,45,46)(H2,28,31,32)(H2,40,41,42)/b7-6+/t16-,20-,21-,22+,26-/m1/s1 EHMN_ABBREVIATION: C05271
initial amount: NaN
name: (2E)-Hexenoyl-CoA
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110061#_c71884bc_6c2e_4dac_93cf_994e31eb7f73
constant: false
boundary condition: true
initial concentration: NaN
has only substance units: false
is: SBO:0000252
type: Species
is encoded by: hsa:AI480132
name: _AI480132_1_c
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110061#_de0ff9bd_47a3_43b8_8be6_109cb27ae3ec
type: Species
boundary condition: true
initial amount: NaN
constant: false
has only substance units: false
is: SBO:0000252
name: B3GALNT1
initial concentration: NaN
is: Q8TDY1
is encoded by: hsa:8706

metaR FAOXC184m
kinetic law: MODEL1310110061#
product: MODEL1310110061#
reactant: MODEL1310110061#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: isomerization of (C18:4)m
type: Reaction

metaR H2O2tm
is described by: ECO:0000000
type: Reaction
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: PMID:2989289 NOTES:it
is: SBO:0000185
product: MODEL1310110061#
name: hydrogen peroxide mitochondrial transport
fast: false
kinetic law: MODEL1310110061#
reactant: MODEL1310110061#

http://identifiers.org/biomodels.db/MODEL1310110061#_6dc9bc36_4766_44ba_8154_5f0cdc4e937b
type: Species
name: PKLR
has only substance units: false
is: P30613
initial amount: NaN
boundary condition: true
initial concentration: NaN
is encoded by: hsa:5313
constant: false
is: SBO:0000252

metaR r2097
fast: false
is: SBO:0000185
reactant: MODEL1310110061#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
is described by: ECO:0000000
reversible: true
kinetic law: MODEL1310110061#
modifier: MODEL1310110061#
type: Reaction
product: MODEL1310110061#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:

metaR FACOAL203
modifier: MODEL1310110061#
kinetic law: MODEL1310110061#
product: MODEL1310110061#
reversible: true
is version of: http://identifiers.org/ec-code/6.2.1.3
notes: GENE_ASSOCIATION: (2180.1) SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 4 AUTHORS: PMID:15292367 NOTES:NJ
fast: false
is: SBO:0000176
is described by: ECO:0000000
type: Reaction
name: fatty-acid--CoA ligase
reactant: MODEL1310110061#

http://identifiers.org/biomodels.db/MODEL1310110061#_75792e49_1ed5_493f_987f_a39740c13976
constant: false
type: Species
is: Q9BYZ2
name: LDHAL6B
boundary condition: true
initial amount: NaN
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:92483
has only substance units: false

metaM fad r
type: Species
boundary condition: false
is: CHEBI:16238
initial concentration: 1.0
has only substance units: false
constant: false
is: HMDB01248
initial amount: NaN
name: Flavin adenine dinucleotide oxidized
notes: FORMULA: C27H31N9O15P2 CHARGE: -2 INCHI: InChI=1S/C27H33N9O15P2/c1-10-3-12-13(4-11(10)2)35(24-18(32-12)25(42)34-27(43)33-24)5-14(37)19(39)15(38)6-48-52(44,45)51-53(46,47)49-7-16-20(40)21(41)26(50-16)36-9-31-17-22(28)29-8-30-23(17)36/h3-4,8-9,14-16,19-21,26,37-41H,5-7H2,1-2H3,(H,44,45)(H,46,47)(H2,28,29,30)(H,34,42,43)/t14-,15+,16+,19-,20+,21+,26+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00026 EHMN_ABBREVIATION: C00016
is: SBO:0000247

metaR FACOAL80i
type: Reaction
reversible: false
is version of: http://identifiers.org/ec-code/6.2.1.3
kinetic law: MODEL1310110061#
product: MODEL1310110061#
is described by: ECO:0000269
name: fatty-acid--CoA ligase (octanoate)
modifier: MODEL1310110061#
reactant: MODEL1310110061#
is: SBO:0000176
notes: GENE_ASSOCIATION: (2181.1) or (2181.2) SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.2 Confidence Level: 4 AUTHORS: NOTES:JLR Also 6.2.1.3
fast: false

metaM aacoa c
boundary condition: false
notes: FORMULA: C25H36N7O18P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00282 EHMN_ABBREVIATION: C00332
is: HMDB01484
is: CHEBI:57286
initial concentration: 1.0
is: C00332
type: Species
constant: false
is: SBO:0000247
initial amount: NaN
has only substance units: false
name: Acetoacetyl-CoA

http://identifiers.org/biomodels.db/MODEL1310110061#_192e949d_c3c7_422e_a8d8_270b4cebb06b
name: UGCG
initial amount: NaN
boundary condition: true
is: SBO:0000252
initial concentration: NaN
constant: false
is: Q16739
has only substance units: false
type: Species
is encoded by: hsa:7357

metaR r1642
fast: false
is: SBO:0000185
reversible: true
reactant: MODEL1310110061#
kinetic law: MODEL1310110061#
is described by: ECO:0000000
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
type: Reaction
modifier: MODEL1310110061#
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
product: MODEL1310110061#

http://identifiers.org/biomodels.db/MODEL1310110061#_9266cd72_930e_4aea_bd63_90a566b5c21f
name: _AI761708_1_m
type: Species
initial concentration: NaN
boundary condition: true
is: SBO:0000252
constant: false
has only substance units: false
initial amount: NaN
is encoded by: hsa:AI761708

metaR r0819
kinetic law: MODEL1310110061#
product: MODEL1310110061#
name: Mitochondrial Carrier (MC) TCDB:2.A.29.2.2
reversible: true
is version of: http://identifiers.org/ec-code/2.3.1.85
modifier: MODEL1310110061#
fast: false
reactant: MODEL1310110061#
is: SBO:0000185
type: Reaction
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (2194.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:10585886,PMID:14598172,PMID:17173541,PMID:18406340,PMID:4424886,PMID:4441366,PMID:5099217,PMID:8329439 NOTES:

metaR ADNK1m
name: adenosine kinase, mitochondrial
is: SBO:0000176
type: Reaction
reactant: MODEL1310110061#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.1.20 Confidence Level: 1 AUTHORS: NOTES:IT
product: MODEL1310110061#
is described by: ECO:0000000
kinetic law: MODEL1310110061#
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110061#_4c4f9e3a_5f13_44af_8802_4cffdae4a550
initial concentration: NaN
has only substance units: false
is: SBO:0000252
name: GBA
constant: false
boundary condition: true
initial amount: NaN
is encoded by: hsa:2629
type: Species

metaR EX hdcea LPAREN e RPAREN
kinetic law: MODEL1310110061#
reactant: MODEL1310110061#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for Hexadecenoate (n-C16:1)
type: Reaction

metaR r1088
is: SBO:0000185
kinetic law: MODEL1310110061#
is described by: ECO:0000000
reversible: true
product: MODEL1310110061#
reactant: MODEL1310110061#
name: Active transport
fast: false
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:10049700,PMID:10574970,PMID:11389679,PMID:11557028,PMID:11564694,PMID:12824232,PMID:12930836,PMID:14574404,PMID:16288981,PMID:911815 NOTES:

metaR r2016
product: MODEL1310110061#
fast: false
reversible: false
modifier: MODEL1310110061#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.15
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
kinetic law: MODEL1310110061#
is: SBO:0000185
type: Reaction
reactant: MODEL1310110061#

metaM cit e
name: citrate(3-)
is: SBO:0000247
initial concentration: 1.0
type: Species
is: CHEBI:16947
initial amount: NaN
notes: FORMULA: C6H5O7 CHARGE: -3 INCHI: InChI=1S/C6H8O7/c7-3(8)1-6(13,5(11)12)2-4(9)10/h13H,1-2H2,(H,7,8)(H,9,10)(H,11,12)/p-3 HEPATONET_1.0_ABBREVIATION: HC00153 EHMN_ABBREVIATION: C00158
constant: false
has only substance units: false
boundary condition: false
is: HMDB00094

metaM asn L c
notes: FORMULA: C4H8N2O3 CHARGE: 0 INCHI: InChI=1S/C4H8N2O3/c5-2(4(8)9)1-3(6)7/h2H,1,5H2,(H2,6,7)(H,8,9)/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00148
is: HMDB00168
is: CHEBI:17196
type: Species
boundary condition: false
constant: false
has only substance units: false
initial amount: NaN
name: L-asparagine
initial concentration: 1.0
is: SBO:0000247

metaR PPCDC
is: SBO:0000176
reversible: false
is described by: ECO:0000269
reactant: MODEL1310110061#
name: phosphopantothenoylcysteine decarboxylase
notes: GENE_ASSOCIATION: (60490.1) SUBSYSTEM: CoA synthesis EC Number: 4.1.1.36 Confidence Level: 4 AUTHORS: PMID:11923312 NOTES:
kinetic law: MODEL1310110061#
product: MODEL1310110061#
modifier: MODEL1310110061#
type: Reaction
fast: false
is version of: http://identifiers.org/ec-code/4.1.1.36

metaR r2098
is described by: ECO:0000000
reversible: true
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
kinetic law: MODEL1310110061#
fast: false
is: SBO:0000185
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
type: Reaction
product: MODEL1310110061#
modifier: MODEL1310110061#
reactant: MODEL1310110061#

metaR FACOAL204
reactant: MODEL1310110061#
product: MODEL1310110061#
notes: GENE_ASSOCIATION: (22305.1) or (2181.2) or (2181.1) or (2180.1) or (22305.2) or (2182.1) or (2182.2) SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 4 AUTHORS: PMID:15292367 NOTES:rev version so additional rxn doesn't need to be added to "unload" AA NJ. Merged GPR from FACOAL204 and FACOAL204i - (May 2011) IT
reversible: true
name: fatty-acid--CoA ligase
is version of: http://identifiers.org/ec-code/6.2.1.3
kinetic law: MODEL1310110061#
modifier: MODEL1310110061#
fast: false
is: SBO:0000176
is described by: ECO:0000269
type: Reaction

metaR SPH1Pte
reactant: MODEL1310110061#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:15585321 NOTES:unknown mechanism for transport, may be vesicular/caveolar/other ... intracellular transport and extracellular export mechanisms must exist - see for example: PMID: 15585321 NJ
is described by: ECO:0000000
fast: false
reversible: true
kinetic law: MODEL1310110061#
name: sph1p transport
product: MODEL1310110061#
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110061#_909db8a4_5ad3_4257_9102_e472c2ab7e2e
is encoded by: hsa:4705
has only substance units: false
type: Species
boundary condition: true
initial amount: NaN
constant: false
initial concentration: NaN
is: SBO:0000252
name: NDUFA10
is: O95299

metaR r0480
name: S-Adenosyl-L-methionine:ethanolamine-phosphate N-methyltransferase Glycerophospholipid metabolism EC:2.1.1.103
reversible: true
reactant: MODEL1310110061#
type: Reaction
is described by: ECO:0000000
is: SBO:0000176
kinetic law: MODEL1310110061#
notes: GENE_ASSOCIATION: SUBSYSTEM: Glycerophospholipid metabolism EC Number: 2.1.1.103 Confidence Level: 0 AUTHORS: PMID:2403362 NOTES:
fast: false
product: MODEL1310110061#

metaR NTD2e
product: MODEL1310110061#
reversible: false
is version of: http://identifiers.org/ec-code/3.1.3.5
modifier: MODEL1310110061#
type: Reaction
reactant: MODEL1310110061#
is: SBO:0000176
name: 5'-nucleotidase (UMP), extracellular
kinetic law: MODEL1310110061#
is described by: ECO:0000134
notes: GENE_ASSOCIATION: (4907.1) SUBSYSTEM: Nucleotide interconversion EC Number: 3.1.3.5 Confidence Level: 2 AUTHORS: PMID:2840110 NOTES:Wide specificity for 5'-nucleotides Also see EC 3.1.3.31
fast: false

metaR VITD3t2
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:I am not sure how vitamin D3 is taken up from peripheral cells based on Vitamins, G.F.M. Ball,2004, Blackwell publishing, 1st ed (book) pg.193 IT
name: Vitamin D3 uptake
type: Reaction
kinetic law: MODEL1310110061#
is: SBO:0000185
reversible: false
is described by: ECO:0000000
reactant: MODEL1310110061#
fast: false
product: MODEL1310110061#

http://identifiers.org/biomodels.db/MODEL1310110061#_614df4af_f069_4eb6_b607_878d1a52529e
is: SBO:0000252
boundary condition: true
constant: false
initial concentration: NaN
name: PMM1
initial amount: NaN
type: Species
is: A8K003
has only substance units: false
is encoded by: hsa:5372

metaR PLA2 2
notes: GENE_ASSOCIATION: (8398.1) or (5320.1) or (8398.2) SUBSYSTEM: Glycerophospholipid metabolism EC Number: 3.1.1.4 Confidence Level: 4 AUTHORS: PMID:9272153,PMID:9417066 NOTES:phosphatidyl choline degradation NJ
reactant: MODEL1310110061#
fast: false
product: MODEL1310110061#
is version of: http://identifiers.org/ec-code/3.1.1.4
is: SBO:0000176
name: phospholipase A2
reversible: false
is described by: ECO:0000000
kinetic law: MODEL1310110061#
modifier: MODEL1310110061#
type: Reaction

metaR r1641
is: SBO:0000185
type: Reaction
product: MODEL1310110061#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
modifier: MODEL1310110061#
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reversible: true
reactant: MODEL1310110061#
kinetic law: MODEL1310110061#
is described by: ECO:0000000
fast: false

metaR r1787
name: Y+LAT2 Utilized transport
kinetic law: MODEL1310110061#
reversible: false
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
modifier: MODEL1310110061#
product: MODEL1310110061#
fast: false
is: SBO:0000185
is described by: ECO:0000000
type: Reaction
reactant: MODEL1310110061#

metaM arach c
is: SBO:0000247
is: CHEBI:32360
initial concentration: 1.0
boundary condition: false
name: arachidate
initial amount: NaN
type: Species
notes: FORMULA: C20H39O2 CHARGE: -1 INCHI: InChI=1S/C20H40O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20(21)22/h2-19H2,1H3,(H,21,22)/p-1 EHMN_ABBREVIATION: CE0102
is: HMDB02212
constant: false
has only substance units: false

metaR r1421
is described by: ECO:0000000
type: Reaction
kinetic law: MODEL1310110061#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: 4.2.1.1 Confidence Level: 0 AUTHORS: PMID:10938543,PMID:11493685,PMID:12713833,PMID:12747791,PMID:14640555,PMID:17259996,PMID:17504134,PMID:17826101,PMID:7011879,PMID:7672338 NOTES:
is: SBO:0000185
reactant: MODEL1310110061#
name: Free diffusion
reversible: true
product: MODEL1310110061#
fast: false

http://identifiers.org/biomodels.db/MODEL1310110061#_7ccc4614_86e8_4dad_8cad_e9f050451a3d
type: Species
is: SBO:0000252
is: O75874
has only substance units: false
constant: false
boundary condition: true
name: IDH1
is encoded by: hsa:3417
initial amount: NaN
initial concentration: NaN

metaR HSD3A2r
name: 3 alpha-hydroxysteroid dehydrogenase (type 3)
fast: false
is: SBO:0000176
reactant: MODEL1310110061#
product: MODEL1310110061#
modifier: MODEL1310110061#
is described by: ECO:0000000
type: Reaction
reversible: true
is version of: http://identifiers.org/ec-code/1.1.1.225
kinetic law: MODEL1310110061#
notes: GENE_ASSOCIATION: (1109.1) SUBSYSTEM: Steroid metabolism EC Number: 1.1.1.225 Confidence Level: 0 AUTHORS: PMID:14643063,PMID:7650035 NOTES:Microsomal rxn see PMID: 14643063 substrate specificity still not clear (nad vs nadp) NJ

metaM 3ddecdicoa m
notes: FORMULA: C33H50N7O17P3S CHARGE: -4
is: C05280
name: 3,6-dodecadienoylcoa
has only substance units: false
constant: false
is: HMDB03952
is: SBO:0000247
type: Species
boundary condition: false
initial amount: NaN
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110061#_9aabf57d_67fd_418a_bb8e_7920602d9c2c
initial amount: NaN
initial concentration: NaN
constant: false
has only substance units: false
is encoded by: hsa:AI620219
is: SBO:0000252
type: Species
name: _AI620219_1_e
boundary condition: true

metaM CE4794 m
notes: FORMULA: C33H52N7O17P3S CHARGE: -4 INCHI: InChI=1/C33H56N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-24(42)61-17-16-35-23(41)14-15-36-31(45)28(44)33(2,3)19-54-60(51,52)57-59(49,50)53-18-22-27(56-58(46,47)48)26(43)32(55-22)40-21-39-25-29(34)37-20-38-30(25)40/h8-9,20-22,26-28,32,43-44H,4-7,10-19H2,1-3H3,(H,35,41)(H,36,45)(H,49,50)(H,51,52)(H2,34,37,38)(H2,46,47,48)/p-4/b9-8-/t22-,26+,27+,28u,32-/m0/s1 EHMN_ABBREVIATION: CE4794
initial amount: NaN
initial concentration: 1.0
is: SBO:0000247
has only substance units: false
name: cis-6-dodecenoyl-CoA
type: Species
constant: false
is: CHEBI:57923
boundary condition: false

metaR FACOAL205
kinetic law: MODEL1310110061#
is version of: http://identifiers.org/ec-code/6.2.1.3
is: SBO:0000176
name: fatty-acid--CoA ligase
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (2180.1) SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 4 AUTHORS: PMID:15292367 NOTES:NJ
type: Reaction
modifier: MODEL1310110061#
fast: false
reactant: MODEL1310110061#
reversible: true
product: MODEL1310110061#

metaR EX estradiol LPAREN e RPAREN
kinetic law: MODEL1310110061#
reactant: MODEL1310110061#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: estradiol exchange
type: Reaction

metaR r2095
type: Reaction
fast: false
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
reactant: MODEL1310110061#
is: SBO:0000185
reversible: true
kinetic law: MODEL1310110061#
is described by: ECO:0000000
modifier: MODEL1310110061#
product: MODEL1310110061#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110061#_0125ba5d_5a1f_43a1_af1c_baf69ef42f93
type: Species
boundary condition: true
initial amount: NaN
initial concentration: NaN
has only substance units: false
is: SBO:0000252
name: DGKD
is encoded by: hsa:8527
is: Q16760
constant: false

metaM dlnlcgcoa c
has only substance units: false
is: CHEBI:27979
initial concentration: 1.0
boundary condition: false
type: Species
constant: false
is: SBO:0000247
notes: FORMULA: C41H64N7O17P3S CHARGE: -4 INCHI: InChI=1S/C41H68N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-32(50)69-25-24-43-31(49)22-23-44-39(53)36(52)41(2,3)27-62-68(59,60)65-67(57,58)61-26-30-35(64-66(54,55)56)34(51)40(63-30)48-29-47-33-37(42)45-28-46-38(33)48/h8-9,11-12,14-15,28-30,34-36,40,51-52H,4-7,10,13,16-27H2,1-3H3,(H,43,49)(H,44,53)(H,57,58)(H,59,60)(H2,42,45,46)(H2,54,55,56)/b9-8-,12-11-,15-14-/t30-,34-,35-,36+,40-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC02102
initial amount: NaN
name: dihomo-gamma-linolenyl coenzyme A

http://identifiers.org/biomodels.db/MODEL1310110061#_dabe67d7_bc6f_42aa_af1a_7b57972e3060
is: Q53Y41
is encoded by: hsa:1644
boundary condition: true
has only substance units: false
type: Species
initial amount: NaN
constant: false
initial concentration: NaN
is: SBO:0000252
name: DDC

http://identifiers.org/biomodels.db/MODEL1310110061#_659d40b5_eb9c_4a11_974e_9b7a006e39ba
initial concentration: NaN
initial amount: NaN
constant: false
type: Species
name: ACSL6
boundary condition: true
has only substance units: false
is: B2RB13
is: SBO:0000252
is encoded by: hsa:23305

http://identifiers.org/biomodels.db/MODEL1310110061#_38905ac4_c246_420c_8179_1a726c5e08ff
is: Q96M32
type: Species
name: AK7
is encoded by: hsa:122481
is: SBO:0000252
initial amount: NaN
constant: false
boundary condition: true
has only substance units: false
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110061#_42452ba1_791b_4d27_8913_14542e61fee2
is: O95954
initial amount: NaN
has only substance units: false
initial concentration: NaN
is: SBO:0000252
name: FTCD
constant: false
boundary condition: true
is encoded by: hsa:10841
type: Species

http://identifiers.org/biomodels.db/MODEL1310110061#_4701b996_9dc2_4878_aab5_75daecb5ede4
is: Q969I6
initial concentration: NaN
constant: false
boundary condition: true
has only substance units: false
is: SBO:0000252
initial amount: NaN
name: SLC38A4
is encoded by: hsa:55089
type: Species

http://identifiers.org/biomodels.db/MODEL1310110061#_6e9980ac_d31a_42c9_ae4d_b2f92aaed408
initial amount: NaN
has only substance units: false
constant: false
initial concentration: NaN
boundary condition: true
is: Q8IV97
name: SLC7A5
is: SBO:0000252
type: Species
is encoded by: hsa:8140

metaR r0817
reversible: true
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.3.2
modifier: MODEL1310110061#
fast: false
reactant: MODEL1310110061#
notes: GENE_ASSOCIATION: (AA177072.1) or (2194.1) or (54995.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:10049700,PMID:10072483,PMID:10391915,PMID:10574970,PMID:11004451,PMID:11311135,PMID:11389679,PMID:11557028,PMID:11564694,PMID:11742812,PMID:11827462,PMID:12117417,PMID:12824232,PMID:12883891,PMID:14574404,PMID:14770310,PMID:15465786,PMID:16082501,PMID:16288981,PMID:17466261,PMID:1904693,PMID:4424190,PMID:6432599,PMID:7690540,PMID:7718542,PMID:9751058,PMID:9759917,PMID:9868191 NOTES:
is: SBO:0000185
type: Reaction
is version of: http://identifiers.org/ec-code/2.3.1.41
product: MODEL1310110061#
is described by: ECO:0000000
kinetic law: MODEL1310110061#
is version of: http://identifiers.org/ec-code/2.3.1.85

metaM HC01496 m
has only substance units: false
boundary condition: false
constant: false
initial amount: NaN
is: SBO:0000247
name: 2-Amino-3-oxoadipate
type: Species
notes: FORMULA: C6H8NO5 CHARGE: -1 INCHI: InChI=1S/C6H9NO5/c7-5(6(11)12)3(8)1-2-4(9)10/h5H,1-2,7H2,(H,9,10)(H,11,12) EHMN_ABBREVIATION: C05520
initial concentration: 1.0
is: CHEBI:28095

http://identifiers.org/biomodels.db/MODEL1310110061#_a59c37b0_ed49_4080_98cc_05116bacde15
boundary condition: true
is encoded by: hsa:23475
is: Q15274
type: Species
is: SBO:0000252
has only substance units: false
initial amount: NaN
initial concentration: NaN
constant: false
name: QPRT

metaR RE2677E
name: RE2677
is described by: ECO:0000000
kinetic law: MODEL1310110061#
reversible: false
reactant: MODEL1310110061#
fast: false
product: MODEL1310110061#
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Glycosphingolipid metabolism EC Number: 2.4.1.47 Confidence Level: 0 AUTHORS: PMID:423891,PMID:9125199 NOTES:IT - fixed proton
type: Reaction

metaR r1644
product: MODEL1310110061#
is: SBO:0000185
fast: false
reactant: MODEL1310110061#
is described by: ECO:0000000
reversible: true
kinetic law: MODEL1310110061#
type: Reaction
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
modifier: MODEL1310110061#
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110061#_b4546822_ea84_4cab_b740_2470849b66eb
type: Species
initial amount: NaN
constant: false
boundary condition: true
has only substance units: false
is: SBO:0000252
is: A8K0I1
is encoded by: hsa:160851
initial concentration: NaN
name: DGKH

metaM asn L e
name: L-asparagine
is: HMDB00168
notes: FORMULA: C4H8N2O3 CHARGE: 0 INCHI: InChI=1S/C4H8N2O3/c5-2(4(8)9)1-3(6)7/h2H,1,5H2,(H2,6,7)(H,8,9)/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00148
is: CHEBI:17196
type: Species
constant: false
initial amount: NaN
boundary condition: false
is: SBO:0000247
has only substance units: false
initial concentration: 1.0

metaM cit c
is: HMDB00094
name: Citrate
notes: FORMULA: C6H5O7 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00153 EHMN_ABBREVIATION: C00158
initial concentration: 1.0
type: Species
has only substance units: false
is: SBO:0000247
is: CHEBI:16947
initial amount: NaN
is: C00158
constant: false
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110061#_97992a5f_bc56_477e_807e_442a898901a2
initial concentration: NaN
has only substance units: false
initial amount: NaN
is: Q8NFW8
constant: false
type: Species
is encoded by: hsa:55907
name: CMAS
is: SBO:0000252
boundary condition: true

metaR r2465
fast: false
is: SBO:0000185
reactant: MODEL1310110061#
is described by: ECO:0000000
type: Reaction
kinetic law: MODEL1310110061#
product: MODEL1310110061#
reversible: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12748859 NOTES:
name: Cation Diffusion Facilitator (CDF) TCDB:2.A.4.2.3

http://identifiers.org/biomodels.db/MODEL1310110061#_4282d6cd_02fe_473e_82e1_c44ca9ece376
is: O14561
is: SBO:0000252
is encoded by: hsa:4706
has only substance units: false
boundary condition: true
constant: false
type: Species
initial amount: NaN
name: NDUFAB1
initial concentration: NaN

metaR C4STMO2r
is: SBO:0000176
fast: false
modifier: MODEL1310110061#
is described by: ECO:0000000
reactant: MODEL1310110061#
is version of: http://identifiers.org/ec-code/1.14.13.72
type: Reaction
name: C-4 methyl sterol oxidase
reversible: false
product: MODEL1310110061#
notes: GENE_ASSOCIATION: (6307.1) or (50814.1) SUBSYSTEM: Cholesterol metabolism EC Number: Confidence Level: 4 AUTHORS: NOTES:double check rxn specifics - see lit ref: Marijanovic, Molecular Endocrinology 2003 17:1715-1725 ER version NJ
is version of: http://identifiers.org/ec-code/1.1.1.170
kinetic law: MODEL1310110061#

metaM tym c
type: Species
has only substance units: false
notes: FORMULA: C8H12NO CHARGE: 1 INCHI: InChI=1S/C8H11NO/c9-6-5-7-1-3-8(10)4-2-7/h1-4,10H,5-6,9H2/p+1 EHMN_ABBREVIATION: C00483
name: tyraminium
initial amount: NaN
is: CHEBI:327995
is: HMDB00306
is: SBO:0000247
boundary condition: false
initial concentration: 1.0
constant: false

metaM CE2422 m
type: Species
is: CHEBI:28387
name: 3-oxo-cis,cis-7,10-hexadecadienoyl-CoA
has only substance units: false
boundary condition: false
notes: FORMULA: C37H56N7O18P3S CHARGE: -4 INCHI: InChI=1/C37H60N7O18P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-25(45)20-28(47)66-19-18-39-27(46)16-17-40-35(50)32(49)37(2,3)22-59-65(56,57)62-64(54,55)58-21-26-31(61-63(51,52)53)30(48)36(60-26)44-24-43-29-33(38)41-23-42-34(29)44/h8-9,11-12,23-24,26,30-32,36,48-49H,4-7,10,13-22H2,1-3H3,(H,39,46)(H,40,50)(H,54,55)(H,56,57)(H2,38,41,42)(H2,51,52,53)/p-4/b9-8-,12-11-/t26-,30+,31+,32u,36-/m0/s1 EHMN_ABBREVIATION: CE2422
initial concentration: 1.0
is: HMDB11123
initial amount: NaN
constant: false
is: SBO:0000247

metaR FAOXC227C226m
kinetic law: MODEL1310110061#
product: MODEL1310110061#
reactant: MODEL1310110061#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C22:7-->C22:6)m
type: Reaction

metaR r2096
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
reversible: true
kinetic law: MODEL1310110061#
is described by: ECO:0000000
fast: false
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
product: MODEL1310110061#
is: SBO:0000185
type: Reaction
modifier: MODEL1310110061#
reactant: MODEL1310110061#

metaR SUCOASm
reactant: MODEL1310110061#
type: Reaction
notes: GENE_ASSOCIATION: (8802.1 and 8803.1) SUBSYSTEM: Citric acid cycle EC Number: 6.2.1.5 Confidence Level: 0 AUTHORS: PMID:9765291 NOTES:MIPS: cofactor ATP IF changed EC from 6.2.1.4 to 6.2.1.5 - NCD
is described by: ECO:0000000
product: MODEL1310110061#
reversible: true
is: SBO:0000176
is version of: http://identifiers.org/ec-code/6.2.1.4
name: Succinate--CoA ligase (ADP-forming)
fast: false
kinetic law: MODEL1310110061#
is version of: http://identifiers.org/ec-code/6.2.1.5
modifier: MODEL1310110061#

metaM retinol c
type: Species
is: SBO:0000247
name: retinol
initial amount: NaN
constant: false
has only substance units: false
initial concentration: 1.0
is: CHEBI:50211
is: HMDB00305
boundary condition: false
notes: FORMULA: C20H30O CHARGE: 0 INCHI: InChI=1S/C20H30O/c1-16(8-6-9-17(2)13-15-21)11-12-19-18(3)10-7-14-20(19,4)5/h6,8-9,11-13,21H,7,10,14-15H2,1-5H3

http://identifiers.org/biomodels.db/MODEL1310110061#_d6f02fcf_fd7f_4319_bcb1_99862840010f
initial concentration: NaN
name: SLC16A2
type: Species
has only substance units: false
constant: false
is encoded by: hsa:6567
is: P36021
is: SBO:0000252
boundary condition: true
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110061#_3dba7329_2cb2_455e_b2b9_7f07b21ade1d
is: GO:0005794
is: SBO:0000290
constant: false
size: 1.0
spatial dimensions: 3.0
name: Golgi apparatus
type: Compartment

http://identifiers.org/biomodels.db/MODEL1310110061#_b97a9000_5af2_43cf_a078_9b8c199f9d4e
initial concentration: NaN
is encoded by: hsa:55577
has only substance units: false
boundary condition: true
type: Species
name: NAGK
is: SBO:0000252
initial amount: NaN
constant: false
is: Q9UJ70

metaR r0196
reversible: true
is version of: http://identifiers.org/ec-code/3.6.1.5
name: Succinyl-CoA:glycine C-succinyl-transferase(decarboxylating) EC:2.3.1.37
is described by: ECO:0000000
modifier: MODEL1310110061#
kinetic law: MODEL1310110061#
product: MODEL1310110061#
notes: GENE_ASSOCIATION: (AV717590.1) or (953.1) or (956.1) or (377841.1) SUBSYSTEM: Unassigned EC Number: 2.3.1.37 Confidence Level: 0 AUTHORS: PMID:7592562 NOTES:
type: Reaction
is: SBO:0000176
reactant: MODEL1310110061#
fast: false

metaR FADtru
name: FAD transporter, endoplasmic reticulum
type: Reaction
product: MODEL1310110061#
kinetic law: MODEL1310110061#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: NOTES:diffusion - but unidirectional output from ER (to avoid loops w/ NAD/NADP) NJ
is described by: ECO:0000000
reversible: false
is: SBO:0000185
fast: false
reactant: MODEL1310110061#

metaM orn m
is: HMDB00214
name: Ornithine
constant: false
notes: FORMULA: C5H13N2O2 CHARGE: 1
initial concentration: 1.0
is: CHEBI:46912
is: C01602
initial amount: NaN
is: SBO:0000247
type: Species
boundary condition: false
has only substance units: false

metaR r1643
product: MODEL1310110061#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
modifier: MODEL1310110061#
reactant: MODEL1310110061#
is described by: ECO:0000000
reversible: true
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
kinetic law: MODEL1310110061#
is: SBO:0000185
type: Reaction
fast: false

metaR EX txa2 LPAREN e RPAREN
kinetic law: MODEL1310110061#
reactant: MODEL1310110061#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Thromboxane A2 exchange
type: Reaction

metaR RE1796R
reactant: MODEL1310110061#
reversible: true
is: SBO:0000176
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/1.1.1.145
modifier: MODEL1310110061#
kinetic law: MODEL1310110061#
notes: GENE_ASSOCIATION: (3283.1) or (3284.1) SUBSYSTEM: Bile acid synthesis EC Number: 5.3.3.1 Confidence Level: 0 AUTHORS: PMID:10599696,PMID:11067870,PMID:11454857,PMID:1401999 NOTES:
name: RE1796
product: MODEL1310110061#
fast: false
type: Reaction

metaR q10h2tc
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: NOTES:
reactant: MODEL1310110061#
is described by: ECO:0000134
reversible: true
is: SBO:0000185
type: Reaction
name: transport of ubiquinol into cytosol
fast: false
product: MODEL1310110061#
kinetic law: MODEL1310110061#

metaM HC01407 m
name: (S)-Hydroxyhexanoyl-CoA
type: Species
initial amount: NaN
boundary condition: false
is: SBO:0000247
is: CHEBI:28276
has only substance units: false
initial concentration: 1.0
constant: false
notes: FORMULA: C27H42N7O18P3S CHARGE: -4 INCHI: InChI=1S/C27H46N7O18P3S/c1-4-5-15(35)10-18(37)56-9-8-29-17(36)6-7-30-25(40)22(39)27(2,3)12-49-55(46,47)52-54(44,45)48-11-16-21(51-53(41,42)43)20(38)26(50-16)34-14-33-19-23(28)31-13-32-24(19)34/h13-16,20-22,26,35,38-39H,4-12H2,1-3H3,(H,29,36)(H,30,40)(H,44,45)(H,46,47)(H2,28,31,32)(H2,41,42,43)/t15-,16+,20+,21+,22-,26+/m0/s1 EHMN_ABBREVIATION: C05268

metaM glx m
has only substance units: false
initial concentration: 1.0
constant: false
is: SBO:0000247
name: glyoxylate
notes: FORMULA: C2H1O3 CHARGE: -1 INCHI: InChI=1S/C2H2O3/c3-1-2(4)5/h1H,(H,4,5)/p-1 EHMN_ABBREVIATION: C00048
boundary condition: false
initial amount: NaN
is: HMDB00119
is: CHEBI:36655
type: Species

metaR IMPC
is version of: http://identifiers.org/ec-code/2.1.2.3
name: IMP cyclohydrolase
reversible: true
is: SBO:0000176
notes: GENE_ASSOCIATION: (471.1) SUBSYSTEM: Purine synthesis EC Number: 3.5.4.10 Confidence Level: 4 AUTHORS: PMID:11948179,PMID:14966129,PMID:9378707 NOTES:
fast: false
kinetic law: MODEL1310110061#
modifier: MODEL1310110061#
reactant: MODEL1310110061#
product: MODEL1310110061#
type: Reaction
is described by: ECO:0000269

metaM 2oxoadp m
is: SBO:0000247
is: HMDB00225
is: CHEBI:57499
initial concentration: 1.0
boundary condition: false
initial amount: NaN
type: Species
name: 2-oxoadipate(2-)
constant: false
has only substance units: false
notes: FORMULA: C6H6O5 CHARGE: -2 INCHI: InChI=1S/C6H8O5/c7-4(6(10)11)2-1-3-5(8)9/h1-3H2,(H,8,9)(H,10,11)/p-2 HEPATONET_1.0_ABBREVIATION: HC00273 EHMN_ABBREVIATION: C00322

metaR r1789
fast: false
kinetic law: MODEL1310110061#
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is: SBO:0000185
name: Y+LAT2 Utilized transport
modifier: MODEL1310110061#
is described by: ECO:0000000
reversible: false
type: Reaction
reactant: MODEL1310110061#
product: MODEL1310110061#

metaM f1a l
initial concentration: 1.0
notes: FORMULA: C22H37N2O15X CHARGE: 0
has only substance units: false
constant: false
name: F1alpha
boundary condition: false
is: SBO:0000247
initial amount: NaN
type: Species
is: HMDB02917
is: CHEBI:17151

metaM ttetddcoa m
boundary condition: false
is: SBO:0000247
initial concentration: 1.0
has only substance units: false
name: trans5,8tetradecadienoylcoa
initial amount: NaN
is: HMDB02288
type: Species
constant: false
notes: FORMULA: C35H54N7O17P3S CHARGE: -4

metaM lnlc e
boundary condition: false
is: SBO:0000247
is: CHEBI:30245
is: HMDB00673
notes: FORMULA: C18H31O2 CHARGE: -1 INCHI: InChI=1S/C18H32O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20/h6-7,9-10H,2-5,8,11-17H2,1H3,(H,19,20)/p-1/b7-6-,10-9-
name: linoleate
initial concentration: 1.0
has only substance units: false
constant: false
initial amount: NaN
type: Species

metaR r2093
product: MODEL1310110061#
reactant: MODEL1310110061#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
kinetic law: MODEL1310110061#
is described by: ECO:0000000
is: SBO:0000185
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
fast: false
reversible: true
modifier: MODEL1310110061#
type: Reaction

metaR UMPK4n
is: SBO:0000176
type: Reaction
fast: false
reactant: MODEL1310110061#
product: MODEL1310110061#
is described by: ECO:0000269
name: UMP kinase (GTP),nuclear
kinetic law: MODEL1310110061#
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
reversible: true
modifier: MODEL1310110061#
is version of: http://identifiers.org/ec-code/2.7.4.14

metaR r1646
reversible: true
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reactant: MODEL1310110061#
modifier: MODEL1310110061#
is described by: ECO:0000000
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
kinetic law: MODEL1310110061#
product: MODEL1310110061#
type: Reaction
fast: false
is: SBO:0000185

metaM pa hs c
initial concentration: 1.0
type: Species
constant: false
has only substance units: false
boundary condition: false
initial amount: NaN
is: CHEBI:57739
name: phosphatidate(2-)
notes: FORMULA: C3H5O4PFULLRCO2FULLR2CO2 CHARGE: -2 EHMN_ABBREVIATION: C00416
is: SBO:0000247

metaM xan x
is: CHEBI:17712
is: SBO:0000247
has only substance units: false
boundary condition: false
name: Xanthine
type: Species
notes: FORMULA: C5H4N4O2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00320 EHMN_ABBREVIATION: C00385
is: C00385
constant: false
initial amount: NaN
initial concentration: 1.0
is: HMDB00292

metaR EX prostge2 LPAREN e RPAREN
kinetic law: MODEL1310110061#
reactant: MODEL1310110061#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Prostaglandin E2 exchange
type: Reaction

metaM fald e
boundary condition: false
is: HMDB01426
initial amount: NaN
name: formaldehyde
has only substance units: false
is: CHEBI:16842
type: Species
notes: FORMULA: CH2O CHARGE: 0 INCHI: InChI=1S/CH2O/c1-2/h1H2 HEPATONET_1.0_ABBREVIATION: HC00070 EHMN_ABBREVIATION: C00067
constant: false
initial concentration: 1.0
is: SBO:0000247

metaR r0400
is: SBO:0000176
modifier: MODEL1310110061#
reversible: true
reactant: MODEL1310110061#
type: Reaction
kinetic law: MODEL1310110061#
is described by: ECO:0000000
fast: false
product: MODEL1310110061#
name: N-acetylneuraminate,ferrocytochrome-b5:oxygen oxidoreductase (N-acetyl-hydroxylating) Aminosugars metabolism EC:1.14.18.2
is version of: http://identifiers.org/ec-code/1.2.4.4
notes: GENE_ASSOCIATION: (594.1) or (641649.1) SUBSYSTEM: Unassigned EC Number: 1.14.18.2 Confidence Level: 0 AUTHORS: PMID:11522391,PMID:12192086 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110061#_debd515f_1218_48d1_9bab_2406656c2626
initial amount: NaN
is encoded by: hsa:4952
boundary condition: true
has only substance units: false
initial concentration: NaN
is: SBO:0000252
type: Species
name: OCRL
constant: false
is: Q01968

metaR r0813
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/2.3.1.85
is: SBO:0000185
kinetic law: MODEL1310110061#
fast: false
reactant: MODEL1310110061#
reversible: false
name: ATP-binding Cassette (ABC) TCDB:3.A.1.208.9
type: Reaction
product: MODEL1310110061#
modifier: MODEL1310110061#
notes: GENE_ASSOCIATION: (2194.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:16847695,PMID:16983557 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110061#_5ae3736a_a7e6_44b0_aaf9_6d48936ffb09
initial concentration: NaN
is: Q02218
name: OGDH
type: Species
is: SBO:0000252
boundary condition: true
initial amount: NaN
constant: false
has only substance units: false
is encoded by: hsa:4967

http://identifiers.org/biomodels.db/MODEL1310110061#_49ea134a_1ec9_45e1_a548_ab02c6300412
is: Q9H845
constant: false
initial concentration: NaN
name: ACAD9
type: Species
initial amount: NaN
has only substance units: false
is: SBO:0000252
is encoded by: hsa:28976
boundary condition: true

metaR GDPtg
name: GDP intracellular transport
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 1 AUTHORS: NOTES:unknown mechanism for transport - likely translocated, unknown transporter/mechanism though NJ
fast: false
product: MODEL1310110061#
is: SBO:0000185
is described by: ECO:0000000
kinetic law: MODEL1310110061#
type: Reaction
reversible: true
reactant: MODEL1310110061#

metaR r2094
reactant: MODEL1310110061#
kinetic law: MODEL1310110061#
is described by: ECO:0000000
modifier: MODEL1310110061#
reversible: true
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
type: Reaction
product: MODEL1310110061#
is: SBO:0000185
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
fast: false

metaR FACOAL200
type: Reaction
reactant: MODEL1310110061#
product: MODEL1310110061#
kinetic law: MODEL1310110061#
notes: GENE_ASSOCIATION: (2180.1) SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 4 AUTHORS: PMID:15292367 NOTES:NJ
fast: false
name: fatty-acid--CoA ligase
is version of: http://identifiers.org/ec-code/6.2.1.3
reversible: true
is described by: ECO:0000269
is: SBO:0000176
modifier: MODEL1310110061#

metaR EX abt LPAREN e RPAREN
kinetic law: MODEL1310110061#
reactant: MODEL1310110061#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: L-Arabinitol exchange
type: Reaction

metaM ala L c
name: L-alanine
is: SBO:0000247
initial concentration: 1.0
notes: FORMULA: C3H7NO2 CHARGE: 0 INCHI: InChI=1S/C3H7NO2/c1-2(4)3(5)6/h2H,4H2,1H3,(H,5,6)/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00048
is: HMDB00161
initial amount: NaN
boundary condition: false
constant: false
type: Species
has only substance units: false
is: CHEBI:16977

metaM 2dpmhobq m
notes: FORMULA: C58H88O4 CHARGE: 0 INCHI: InChI=1S/C58H88O4/c1-43(2)23-14-24-44(3)25-15-26-45(4)27-16-28-46(5)29-17-30-47(6)31-18-32-48(7)33-19-34-49(8)35-20-36-50(9)37-21-38-51(10)39-22-40-52(11)41-42-54-53(12)55(59)57(61)58(62-13)56(54)60/h23,25,27,29,31,33,35,37,39,41,61H,14-22,24,26,28,30,32,34,36,38,40,42H2,1-13H3/b44-25+,45-27+,46-29+,47-31+,48-33+,49-35+,50-37+,51-39+,52-41+
constant: false
has only substance units: false
initial amount: NaN
name: 2-decaprenyl-5-hydroxy-6-methoxy-3-methyl-1,4-benzoquinone
initial concentration: 1.0
type: Species
boundary condition: false
is: CHEBI:50771
is: SBO:0000247
is: HMDB06484

metaM cdp n
initial amount: NaN
has only substance units: false
constant: false
is: CHEBI:58069
type: Species
boundary condition: false
is: SBO:0000247
is: HMDB01546
initial concentration: 1.0
notes: FORMULA: C9H12N3O11P2 CHARGE: -3 INCHI: InChI=1S/C9H15N3O11P2/c10-5-1-2-12(9(15)11-5)8-7(14)6(13)4(22-8)3-21-25(19,20)23-24(16,17)18/h1-2,4,6-8,13-14H,3H2,(H,19,20)(H2,10,11,15)(H2,16,17,18)/p-3/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00110 EHMN_ABBREVIATION: C00112
name: CDP(3-)

metaR r1645
modifier: MODEL1310110061#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reversible: true
reactant: MODEL1310110061#
fast: false
is: SBO:0000185
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
kinetic law: MODEL1310110061#
product: MODEL1310110061#
type: Reaction

metaR CO2t
product: MODEL1310110061#
is described by: ECO:0000000
name: CO2 transporter via diffusion
is: SBO:0000185
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 1 AUTHORS: NOTES:tv renamed from CO2TPr to CO2t NCD
fast: false
type: Reaction
reactant: MODEL1310110061#
kinetic law: MODEL1310110061#

metaR EX cdp LPAREN e RPAREN
kinetic law: MODEL1310110061#
reactant: MODEL1310110061#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: CDP(3-) exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110061#_56c0299c_a4a0_4442_ba0f_f7f78fdb442c
type: Species
name: ALDH3A1
constant: false
is: P30838
initial concentration: NaN
has only substance units: false
initial amount: NaN
boundary condition: true
is encoded by: hsa:218
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110061#_030c7966_b699_4371_a1e3_839c404372c7
type: Species
boundary condition: true
has only substance units: false
is: P17735
constant: false
name: TAT
is encoded by: hsa:6898
is: SBO:0000252
initial concentration: NaN
initial amount: NaN

metaR EX 4hpro LPAREN e RPAREN
kinetic law: MODEL1310110061#
reactant: MODEL1310110061#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for hydroxy proline
type: Reaction

metaM acnam n
initial concentration: 1.0
has only substance units: false
type: Species
constant: false
is: HMDB00230
is: SBO:0000247
is: CHEBI:35418
notes: FORMULA: C11H18NO9 CHARGE: -1 INCHI: InChI=1S/C11H19NO9/c1-4(14)12-7-5(15)2-11(20,10(18)19)21-9(7)8(17)6(16)3-13/h5-9,13,15-17,20H,2-3H2,1H3,(H,12,14)(H,18,19)/p-1/t5-,6+,7+,8+,9+,11?/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00244 EHMN_ABBREVIATION: C00270
name: N-acetylneuraminate
boundary condition: false
initial amount: NaN

metaR r0812
is version of: http://identifiers.org/ec-code/2.3.1.41
kinetic law: MODEL1310110061#
notes: GENE_ASSOCIATION: (AA177072.1) or (2194.1) or (54995.1) SUBSYSTEM: Purine catabolism EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:18406340,PMID:9759482 NOTES:
is version of: http://identifiers.org/ec-code/2.3.1.85
reversible: true
reactant: MODEL1310110061#
fast: false
modifier: MODEL1310110061#
is: SBO:0000185
type: Reaction
product: MODEL1310110061#
name: Mitochondrial Carrier (MC) TCDB:2.A.29.20.1
is described by: ECO:0000000

metaR GGH 7THFe
name: Gamma-glutamyl hydrolase (7THF), extracellular
reactant: MODEL1310110061#
is described by: ECO:0000000
reversible: false
product: MODEL1310110061#
modifier: MODEL1310110061#
kinetic law: MODEL1310110061#
notes: GENE_ASSOCIATION: (8836.1) SUBSYSTEM: Folate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:11375437,PMID:2867095,PMID:9614206 NOTES:REMOVES EITHER ONE OR TWO GLUTAMYL RESIDUES WITH A REACTION (WILL ONLY REPRESENT 1) IT
fast: false
type: Reaction
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.4.19.9

metaM estrone r
type: Species
is: HMDB00145
name: estrone
initial concentration: 1.0
has only substance units: false
initial amount: NaN
is: CHEBI:17263
constant: false
boundary condition: false
notes: FORMULA: C18H22O2 CHARGE: 0 INCHI: InChI=1S/C18H22O2/c1-18-9-8-14-13-5-3-12(19)10-11(13)2-4-15(14)16(18)6-7-17(18)20/h3,5,10,14-16,19H,2,4,6-9H2,1H3/t14-,15-,16+,18+/m1/s1 EHMN_ABBREVIATION: C00468
is: SBO:0000247

metaM dhcrm hs c
boundary condition: false
is: CHEBI:31488
type: Species
name: dihydroceramide
initial concentration: 1.0
constant: false
initial amount: NaN
notes: FORMULA: C18H38NO2FULLRCO CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC02158 EHMN_ABBREVIATION: C12126
has only substance units: false
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110061#_21eedcd3_abd1_4dc2_8023_9c012b9af1c9
boundary condition: true
type: Species
is: Q99944
constant: false
has only substance units: false
initial amount: NaN
is: SBO:0000252
is encoded by: hsa:80864
initial concentration: NaN
name: EGFL8

http://identifiers.org/biomodels.db/MODEL1310110061#_c1efa960_c739_4550_be96_3c5f0f1cfd7f
initial amount: NaN
is encoded by: hsa:6532
type: Species
name: SLC6A4
is: P31645
has only substance units: false
constant: false
initial concentration: NaN
boundary condition: true
is: SBO:0000252

metaR RE3566C
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Eicosanoid metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:234423 NOTES:
kinetic law: MODEL1310110061#
product: MODEL1310110061#
type: Reaction
reactant: MODEL1310110061#
reversible: true
is described by: ECO:0000000
is: SBO:0000176
name: RE3566

metaR r2091
type: Reaction
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
reactant: MODEL1310110061#
kinetic law: MODEL1310110061#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
is described by: ECO:0000000
is: SBO:0000185
reversible: true
fast: false
product: MODEL1310110061#
modifier: MODEL1310110061#

metaR r0780
notes: GENE_ASSOCIATION: (30.1) or (10449.1) or (3032.1) or (4645.1) SUBSYSTEM: Cholesterol metabolism EC Number: 1.3.1.70 Confidence Level: 0 AUTHORS: PMID:11969204,PMID:7946524 NOTES:
kinetic law: MODEL1310110061#
name: 4,4-dimethyl-5a-cholesta-8,24-dien-3b-ol:NADP+ D14-oxidoreductase Biosynthesis of steroids EC:1.3.1.70
type: Reaction
product: MODEL1310110061#
fast: false
reversible: true
is: SBO:0000176
is described by: ECO:0000000
modifier: MODEL1310110061#
reactant: MODEL1310110061#
is version of: http://identifiers.org/ec-code/2.3.1.16

metaR r1648
reactant: MODEL1310110061#
reversible: true
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is described by: ECO:0000000
modifier: MODEL1310110061#
type: Reaction
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
fast: false
is: SBO:0000185
kinetic law: MODEL1310110061#
product: MODEL1310110061#

metaR UDPGALtg
reactant: MODEL1310110061#
name: UDP-Gal Golgi transport via CMP antiport
fast: false
is: SBO:0000185
is described by: ECO:0000269
kinetic law: MODEL1310110061#
notes: GENE_ASSOCIATION: (7355.1) SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 4 AUTHORS: PMID:11784306,PMID:8889805,PMID:9010752,PMID:9399569,PMID:9562625 NOTES:NCD
product: MODEL1310110061#
type: Reaction
reversible: true
modifier: MODEL1310110061#

metaM 3mb2coa m
is: SBO:0000247
notes: FORMULA: C26H38N7O17P3S CHARGE: -4 INCHI: InChI=1S/C26H42N7O17P3S/c1-14(2)9-17(35)54-8-7-28-16(34)5-6-29-24(38)21(37)26(3,4)11-47-53(44,45)50-52(42,43)46-10-15-20(49-51(39,40)41)19(36)25(48-15)33-13-32-18-22(27)30-12-31-23(18)33/h9,12-13,15,19-21,25,36-37H,5-8,10-11H2,1-4H3,(H,28,34)(H,29,38)(H,42,43)(H,44,45)(H2,27,30,31)(H2,39,40,41)/p-4/t15-,19-,20-,21+,25-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01047 EHMN_ABBREVIATION: C03069
boundary condition: false
initial concentration: 1.0
has only substance units: false
type: Species
is: HMDB01493
initial amount: NaN
is: CHEBI:57344
constant: false
name: 3-methylbut-2-enoyl-CoA(4-)

metaM 4abutn e
notes: FORMULA: C4H10NO CHARGE: 1 INCHI: InChI=1S/C4H9NO/c5-3-1-2-4-6/h4H,1-3,5H2/p+1 HEPATONET_1.0_ABBREVIATION: HC00428 EHMN_ABBREVIATION: C00555
type: Species
is: HMDB01080
boundary condition: false
is: CHEBI:58264
constant: false
is: SBO:0000247
initial concentration: 1.0
name: 4-ammoniobutanal
has only substance units: false
initial amount: NaN

metaR GCC2cm
is: SBO:0000176
type: Reaction
reactant: MODEL1310110061#
reversible: true
kinetic law: MODEL1310110061#
is version of: http://identifiers.org/ec-code/1.8.1.4
is version of: http://identifiers.org/ec-code/1.4.4.2
name: glycine-cleavage complex (lipoamide), mitochondrial
is described by: ECO:0000269
fast: false
product: MODEL1310110061#
is version of: http://identifiers.org/ec-code/2.1.2.10
modifier: MODEL1310110061#
notes: GENE_ASSOCIATION: (275.1) and (1738.1) and (2731.1) and (2653.1) SUBSYSTEM: Glycine, serine, alanine and threonine metabolism EC Number: 2.1.2.10 Confidence Level: 4 AUTHORS: PMID:15355973 NOTES:NCD

metaR SQLSr
modifier: MODEL1310110061#
type: Reaction
is: SBO:0000176
reactant: MODEL1310110061#
notes: GENE_ASSOCIATION: (2222.1) SUBSYSTEM: Cholesterol metabolism EC Number: 2.5.1.21 Confidence Level: 4 AUTHORS: PMID:1318747 NOTES:This is a lumped reaction: Rxn 1: 2 frdp -> 2 ppi + presqualene diphosphate Rxn 2: presqualene diphosphate + NADPH -> squalene + NADP NCD ER version - NJ
kinetic law: MODEL1310110061#
is version of: http://identifiers.org/ec-code/2.5.1.21
reversible: false
fast: false
is described by: ECO:0000134
product: MODEL1310110061#
name: Squalene synthase

metaR RE0512M
is version of: http://identifiers.org/ec-code/1.1.1.35
is version of: http://identifiers.org/ec-code/4.2.1.17
kinetic law: MODEL1310110061#
reactant: MODEL1310110061#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.3.1.16
modifier: MODEL1310110061#
type: Reaction
product: MODEL1310110061#
reversible: true
is version of: http://identifiers.org/ec-code/4.2.1.107
name: RE0512
fast: false
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (3030.1) or (3295.1) or (1962.1) or (3033.1) or (3028.1) or (3032.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.1.1.35 Confidence Level: 0 AUTHORS: PMID:7846063 NOTES:

metaM fad m
is: HMDB01248
type: Species
initial amount: NaN
has only substance units: false
notes: FORMULA: C27H31N9O15P2 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00026 EHMN_ABBREVIATION: C00016
constant: false
initial concentration: 1.0
name: Flavin adenine dinucleotide oxidized
is: C00016
is: CHEBI:16238
boundary condition: false
is: SBO:0000247

metaR NADPtru
kinetic law: MODEL1310110061#
is described by: ECO:0000000
reversible: false
is: SBO:0000185
product: MODEL1310110061#
fast: false
reactant: MODEL1310110061#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: NOTES:diffusion - but unidirectional output from ER (to avoid loops w/ NAD/NADP) NJ
name: NADP transporter, endoplasmic reticulum

metaM 3oddcoa m
has only substance units: false
constant: false
type: Species
is: SBO:0000247
initial amount: NaN
boundary condition: false
is: CHEBI:27868
initial concentration: 1.0
name: 3-Oxododecanoyl-CoA
notes: FORMULA: C33H52N7O18P3S CHARGE: -4 INCHI: InChI=1S/C33H56N7O18P3S/c1-4-5-6-7-8-9-10-11-21(41)16-24(43)62-15-14-35-23(42)12-13-36-31(46)28(45)33(2,3)18-55-61(52,53)58-60(50,51)54-17-22-27(57-59(47,48)49)26(44)32(56-22)40-20-39-25-29(34)37-19-38-30(25)40/h19-20,22,26-28,32,44-45H,4-18H2,1-3H3,(H,35,42)(H,36,46)(H,50,51)(H,52,53)(H2,34,37,38)(H2,47,48,49)/t22-,26-,27-,28+,32-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01402 EHMN_ABBREVIATION: C05263
is: HMDB03937

metaM acgam6p c
is: CHEBI:57513
initial concentration: 1.0
name: N-acetyl-D-glucosamine 6-phosphate(2-)
is: SBO:0000247
type: Species
notes: FORMULA: C8H14NO9P CHARGE: -2 INCHI: InChI=1S/C8H16NO9P/c1-3(10)9-5-7(12)6(11)4(18-8(5)13)2-17-19(14,15)16/h4-8,11-13H,2H2,1H3,(H,9,10)(H2,14,15,16)/p-2/t4-,5-,6-,7-,8?/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00303 EHMN_ABBREVIATION: C00357
initial amount: NaN
is: HMDB01062
boundary condition: false
constant: false
has only substance units: false

metaM lneldccrn m
type: Species
initial amount: NaN
initial concentration: 1.0
is: HMDB06461
name: Linoelaidyl carnitine
notes: FORMULA: C25H45NO4 CHARGE: 0 INCHI: InChI=1/C25H45NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-25(29)30-23(21-24(27)28)22-26(2,3)4/h9-10,12-13,23H,5-8,11,14-22H2,1-4H3/b10-9+,13-12+
has only substance units: false
is: SBO:0000247
boundary condition: false
constant: false

metaR r2092
fast: false
reactant: MODEL1310110061#
kinetic law: MODEL1310110061#
modifier: MODEL1310110061#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
reversible: true
product: MODEL1310110061#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
type: Reaction
is: SBO:0000185

metaR r0781
reactant: MODEL1310110061#
reversible: true
is version of: http://identifiers.org/ec-code/1.1.1.35
is version of: http://identifiers.org/ec-code/4.2.1.107
fast: false
kinetic law: MODEL1310110061#
type: Reaction
name: Lanosterol,NADPH:oxygen oxidoreductase (14-methyl cleaving) Biosynthesis of steroids EC:1.14.13.70
notes: GENE_ASSOCIATION: (1962.1) or (3033.1) or (3030.1) or (3028.1) or (3295.1) SUBSYSTEM: Cholesterol metabolism EC Number: 1.14.13.70 Confidence Level: 0 AUTHORS: PMID:11969204,PMID:7946524 NOTES:
modifier: MODEL1310110061#
is version of: http://identifiers.org/ec-code/4.2.1.17
is: SBO:0000176
is described by: ECO:0000000
product: MODEL1310110061#

http://identifiers.org/biomodels.db/MODEL1310110061#_1ef9ba50_4fa1_4e30_972e_2d0d01e0f85d
initial concentration: NaN
type: Species
has only substance units: false
is: Q9UHW9
initial amount: NaN
name: SLC12A6
is encoded by: hsa:9990
constant: false
boundary condition: true
is: SBO:0000252

metaR r1647
kinetic law: MODEL1310110061#
modifier: MODEL1310110061#
product: MODEL1310110061#
reversible: true
reactant: MODEL1310110061#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
fast: false
is: SBO:0000185
is described by: ECO:0000000
type: Reaction
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110061#_782d371f_ef14_4bff_a9f7_7f9cb341565d
name: SDHA
boundary condition: true
is: SBO:0000252
is encoded by: hsa:6389
initial concentration: NaN
is: P31040
has only substance units: false
constant: false
initial amount: NaN
type: Species

metaM hmgcoa c
is: CHEBI:15467
is: HMDB01375
has only substance units: false
constant: false
initial concentration: 1.0
type: Species
boundary condition: false
notes: FORMULA: C27H39N7O20P3S CHARGE: -5 INCHI: InChI=1S/C27H44N7O20P3S/c1-26(2,21(40)24(41)30-5-4-15(35)29-6-7-58-17(38)9-27(3,42)8-16(36)37)11-51-57(48,49)54-56(46,47)50-10-14-20(53-55(43,44)45)19(39)25(52-14)34-13-33-18-22(28)31-12-32-23(18)34/h12-14,19-21,25,39-40,42H,4-11H2,1-3H3,(H,29,35)(H,30,41)(H,36,37)(H,46,47)(H,48,49)(H2,28,31,32)(H2,43,44,45)/t14-,19-,20-,21+,25-,27+/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00302 EHMN_ABBREVIATION: C00356
name: Hydroxymethylglutaryl-CoA
is: SBO:0000247
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110061#_e6fbd09d_c316_44a6_9739_d83f584a9595
is encoded by: hsa:4719
type: Species
has only substance units: false
is: P28331
is: SBO:0000252
name: NDUFS1
initial amount: NaN
initial concentration: NaN
constant: false
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110061#_2b0d950a_4ea9_416f_bac7_210d8827cac5
type: Species
has only substance units: false
initial concentration: NaN
constant: false
is: SBO:0000252
is: Q92835
initial amount: NaN
is encoded by: hsa:3635
name: INPP5D
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110061#_863c094c_49ad_4a6f_aa2f_92257d4fe41f
is: SBO:0000252
name: ACOX3
is encoded by: hsa:8310
boundary condition: true
initial amount: NaN
constant: false
has only substance units: false
type: Species
is: O15254
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110061#_405d59c2_71a1_40cb_a679_08a63e398c8c
constant: false
has only substance units: false
boundary condition: true
name: ALDOA
is: SBO:0000252
is: P04075
type: Species
is encoded by: hsa:226
initial concentration: NaN
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110061#_41823a59_5e22_4702_a7f5_4762966c3378
initial amount: NaN
has only substance units: false
constant: false
is encoded by: hsa:D87002
is: SBO:0000252
type: Species
initial concentration: NaN
boundary condition: true
name: _D87002_1_e

metaM akg m
name: 2-Oxoglutarate
notes: FORMULA: C5H4O5 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00035 EHMN_ABBREVIATION: C00026
boundary condition: false
type: Species
is: CHEBI:16810
initial concentration: 1.0
is: SBO:0000247
has only substance units: false
is: C00026
constant: false
initial amount: NaN
is: HMDB00208

metaR NACHEXA20ly
kinetic law: MODEL1310110061#
fast: false
product: MODEL1310110061#
type: Reaction
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.2.1.52
reversible: false
reactant: MODEL1310110061#
modifier: MODEL1310110061#
notes: GENE_ASSOCIATION: (3073.1) or (3073.1 and 3074.1) SUBSYSTEM: Keratan sulfate degradation EC Number: Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12706724,PMID:8993162 NOTES:Note that this reaction is specific to beta-N-acetylhexosaminidase A and cannot be catalyzed by beta-N-acetylhexosaminidase B (or presumably beta-N-acetylhexosaminidase S). This is also a lumped reaction, representing the cleavage of GalNAc4S or GalNAc6S and N-acetylgalactosamine 4-sulfatase or 6-sulfatase. NCD
name: beta-N-acetylhexosaminidase A, lysosomal
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110061#_ddae8e18_0737_4598_a719_7488e4581315
is: SBO:0000252
has only substance units: false
name: ACAA1
constant: false
is encoded by: hsa:30
type: Species
is: Q96CA6
boundary condition: true
initial amount: NaN
initial concentration: NaN

W3 CDTF: Fri Aug 31 06:35:59 BST 2012

metaM CE2431 m
is: CHEBI:57795
notes: FORMULA: C31H48N7O17P3S CHARGE: -4 INCHI: InChI=1/C31H52N7O17P3S/c1-4-5-6-7-8-9-10-11-22(40)59-15-14-33-21(39)12-13-34-29(43)26(42)31(2,3)17-52-58(49,50)55-57(47,48)51-16-20-25(54-56(44,45)46)24(41)30(53-20)38-19-37-23-27(32)35-18-36-28(23)38/h8-9,18-20,24-26,30,41-42H,4-7,10-17H2,1-3H3,(H,33,39)(H,34,43)(H,47,48)(H,49,50)(H2,32,35,36)(H2,44,45,46)/p-4/b9-8-/t20-,24+,25+,26u,30-/m0/s1 EHMN_ABBREVIATION: CE2431
boundary condition: false
initial concentration: 1.0
has only substance units: false
type: Species
initial amount: NaN
name: cis-deca-4-enoyl-CoA
is: SBO:0000247
constant: false

http://identifiers.org/biomodels.db/MODEL1310110061#_708c65b9_06ba_49df_ac19_7f087420b749
boundary condition: true
type: Species
initial concentration: NaN
name: SHMT1
is encoded by: hsa:6470
initial amount: NaN
is: SBO:0000252
is: P34896
has only substance units: false
constant: false

metaR EX gln L LPAREN e RPAREN
kinetic law: MODEL1310110061#
reactant: MODEL1310110061#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for L-glutamine
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110061#_a6daea20_f365_4216_b875_a4006662cda9
type: Species
is: SBO:0000252
is encoded by: hsa:257202
initial amount: NaN
constant: false
name: GPX6
boundary condition: true
has only substance units: false
is: P59796
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110061#_fcfc375c_2cbe_4841_bb8a_2b97699148cc
initial concentration: NaN
is: SBO:0000252
initial amount: NaN
name: CROT
is: E7EQF2
type: Species
has only substance units: false
constant: false
is encoded by: hsa:54677
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110061#_8906d152_62aa_46b9_a3cd_90f0b93f95bf
constant: false
initial concentration: NaN
is encoded by: hsa:5335
type: Species
is: P19174
name: PLCG1
is: SBO:0000252
initial amount: NaN
has only substance units: false
boundary condition: true

metaR TKT2
reactant: MODEL1310110061#
is: SBO:0000176
fast: false
is described by: ECO:0000000
type: Reaction
product: MODEL1310110061#
modifier: MODEL1310110061#
reversible: true
notes: GENE_ASSOCIATION: (7086.1) or (84076.1) or (8277.1) SUBSYSTEM: Pentose phosphate pathway EC Number: 2.2.1.1 Confidence Level: 0 AUTHORS: NOTES:SMP Two reactions for transketolase: TKT1 and TKT2
is version of: http://identifiers.org/ec-code/2.2.1.1
name: transketolase
kinetic law: MODEL1310110061#

metaR r1569
type: Reaction
is: SBO:0000185
product: MODEL1310110061#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
kinetic law: MODEL1310110061#
reactant: MODEL1310110061#
is described by: ECO:0000000
fast: false
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:

metaR r1649
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
modifier: MODEL1310110061#
product: MODEL1310110061#
reactant: MODEL1310110061#
is described by: ECO:0000000
kinetic law: MODEL1310110061#
is: SBO:0000185
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
fast: false
type: Reaction
reversible: true

metaM HC02214 c
is: SBO:0000247
initial concentration: 1.0
notes: FORMULA: C20H35O5 CHARGE: -1 INCHI: InChI=1S/C20H36O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h12-13,15-19,21-23H,2-11,14H2,1H3,(H,24,25)/b13-12+/t15-,16+,17+,18-,19+/m0/s1
boundary condition: false
type: Species
is: CHEBI:28852
name: prostaglandin-f1alpha
constant: false
initial amount: NaN
has only substance units: false

metaR r0403
reactant: MODEL1310110061#
name: L-Tryptophan,tetrahydrobiopterin:oxygen oxidoreductase (5-hydroxylating) Tryptophan metabolism EC:1.14.16.4
modifier: MODEL1310110061#
type: Reaction
is described by: ECO:0000000
fast: false
product: MODEL1310110061#
reversible: true
kinetic law: MODEL1310110061#
is version of: http://identifiers.org/ec-code/1.2.4.4
notes: GENE_ASSOCIATION: (594.1) or (641649.1) SUBSYSTEM: Tetrahydrobiopterin metabolism EC Number: 1.14.16.4 Confidence Level: 0 AUTHORS: NOTES:
is: SBO:0000176

metaM 4hexdtetcoa m
name: 4,7,10,13-hexadecatetraenoylcoa
has only substance units: false
is: HMDB02288
boundary condition: false
initial concentration: 1.0
type: Species
initial amount: NaN
notes: FORMULA: C37H54N7O17P3S CHARGE: -4
is: SBO:0000247
constant: false

metaM 2dr5p c
is: HMDB01031
notes: FORMULA: C5H9O7P CHARGE: -2 INCHI: InChI=1S/C5H11O7P/c6-2-1-4(7)5(8)3-12-13(9,10)11/h2,4-5,7-8H,1,3H2,(H2,9,10,11)/p-2/t4-,5+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00490 EHMN_ABBREVIATION: C00673
has only substance units: false
boundary condition: false
constant: false
name: 2-deoxy-D-ribose 5-phosphate(2-)
is: SBO:0000247
type: Species
is: CHEBI:57651
initial concentration: 1.0
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110061#_52f71d8e_7347_483c_815b_d3e8d74cc6f0
initial concentration: NaN
boundary condition: true
initial amount: NaN
constant: false
name: SLC6A9
has only substance units: false
type: Species
is: P48067
is: SBO:0000252
is encoded by: hsa:6536

metaM man l
notes: FORMULA: C6H12O6 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00154 EHMN_ABBREVIATION: C00159
is: SBO:0000247
constant: false
initial amount: NaN
is: CHEBI:16024
initial concentration: 1.0
type: Species
name: D-mannose
is: HMDB00169
has only substance units: false
boundary condition: false

metaR EX gam LPAREN e RPAREN
kinetic law: MODEL1310110061#
reactant: MODEL1310110061#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for D-Glucosamine
type: Reaction

metaR ARGtiDF
is described by: ECO:0000269
product: MODEL1310110061#
fast: false
reversible: false
is: SBO:0000185
name: L-arginine transport via diffusion (extracellular to cytosol)
type: Reaction
modifier: MODEL1310110061#
notes: GENE_ASSOCIATION: (6541.1) or (6542.1) or (55089.1) or (84889.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:11342143,PMID:11414754,PMID:11591158,PMID:11891586,PMID:12049641,PMID:1348489,PMID:14770310,PMID:7534987,PMID:8954799 NOTES:SAB
reactant: MODEL1310110061#
kinetic law: MODEL1310110061#

metaR EX ksii core2 LPAREN e RPAREN
kinetic law: MODEL1310110061#
reactant: MODEL1310110061#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: keratan sulfate II (core 2-linked) exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110061#_8429f8b2_bf3c_4ee7_82b8_f6ed23833da3
is: P14679
has only substance units: false
initial amount: NaN
is encoded by: hsa:7299
constant: false
name: TYR
boundary condition: true
type: Species
is: SBO:0000252
initial concentration: NaN

metaM xan c
is: HMDB00292
is: SBO:0000247
boundary condition: false
initial amount: NaN
has only substance units: false
is: CHEBI:17712
notes: FORMULA: C5H4N4O2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00320 EHMN_ABBREVIATION: C00385
name: Xanthine
initial concentration: 1.0
type: Species
constant: false
is: C00385

metaM dcsptn1coa x
initial amount: NaN
has only substance units: false
name: docosa-4,7,10,13,16-pentaenoyl coenzyme A
constant: false
notes: FORMULA: C43H64N7O17P3S CHARGE: -4 INCHI: InChI=1/C43H68N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-34(52)71-27-26-45-33(51)24-25-46-41(55)38(54)43(2,3)29-64-70(61,62)67-69(59,60)63-28-32-37(66-68(56,57)58)36(53)42(65-32)50-31-49-35-39(44)47-30-48-40(35)50/h8-9,11-12,14-15,17-18,20-21,30-32,36-38,42,53-54H,4-7,10,13,16,19,22-29H2,1-3H3,(H,45,51)(H,46,55)(H,59,60)(H,61,62)(H2,44,47,48)(H2,56,57,58)/b9-8-,12-11-,15-14-,18-17-,21-20-/t32-,36-,37?,38+,42-/m1/s1
is: SBO:0000247
is: C16173
is: HMDB06513
initial concentration: 1.0
type: Species
is: http://identifiers.org/pubchem.compound/47205483
boundary condition: false

metaM CE2418 m
type: Species
has only substance units: false
is: HMDB11123
notes: FORMULA: C37H58N7O18P3S CHARGE: -4 INCHI: InChI=1/C37H62N7O18P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-25(45)20-28(47)66-19-18-39-27(46)16-17-40-35(50)32(49)37(2,3)22-59-65(56,57)62-64(54,55)58-21-26-31(61-63(51,52)53)30(48)36(60-26)44-24-43-29-33(38)41-23-42-34(29)44/h8-9,11-12,23-26,30-32,36,45,48-49H,4-7,10,13-22H2,1-3H3,(H,39,46)(H,40,50)(H,54,55)(H,56,57)(H2,38,41,42)(H2,51,52,53)/p-4/b9-8-,12-11-/t25-,26-,30+,31+,32u,36-/m0/s1 EHMN_ABBREVIATION: CE2418
is: CHEBI:28387
constant: false
initial concentration: 1.0
is: SBO:0000247
initial amount: NaN
boundary condition: false
name: (3S)-3-hydroxy-cis,cis-palmito-7,10-dienoyl-CoA

metaM dpcoa c
name: Dephospho-CoA
is: C00882
is: CHEBI:57328
boundary condition: false
type: Species
initial concentration: 1.0
initial amount: NaN
is: SBO:0000247
notes: FORMULA: C21H33N7O13P2S CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00575 EHMN_ABBREVIATION: C00882
is: HMDB01373
has only substance units: false
constant: false

metaR RE1796M
reactant: MODEL1310110061#
fast: false
modifier: MODEL1310110061#
kinetic law: MODEL1310110061#
product: MODEL1310110061#
type: Reaction
reversible: true
is version of: http://identifiers.org/ec-code/1.1.1.145
name: RE1796
is: SBO:0000176
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (3283.1) or (3284.1) SUBSYSTEM: Bile acid synthesis EC Number: 5.3.3.1 Confidence Level: 0 AUTHORS: PMID:10599696,PMID:11067870,PMID:11454857,PMID:1401999 NOTES:

metaR r0475
reactant: MODEL1310110061#
is described by: ECO:0000000
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Nucleotide interconversion EC Number: 1.17.4.1 Confidence Level: 0 AUTHORS: PMID:6121703,PMID:8074691 NOTES:
type: Reaction
product: MODEL1310110061#
kinetic law: MODEL1310110061#
name: 2-Deoxyadenosine 5-diphosphate:oxidized-thioredoxin 2-oxidoreductase Purine metabolism EC:1.17.4.1
fast: false
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110061#_0e3c264e_2f0f_4886_90cb_da2a9626af2d
constant: false
is encoded by: hsa:AL038231
initial concentration: NaN
is: SBO:0000252
type: Species
initial amount: NaN
has only substance units: false
boundary condition: true
name: _AL038231_1_c

metaR LDH L
type: Reaction
is: SBO:0000176
fast: false
notes: GENE_ASSOCIATION: (3945.1 and 3939.1) or (160287.1) or (3948.2) or (3939.1) or (3948.1) or (55293.1) or (3945.1) or (92483.1) SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: 1.1.1.27 Confidence Level: 0 AUTHORS: PMID:11377399,PMID:15240094,PMID:2440048 NOTES:Also see LDL_D
is described by: ECO:0000000
product: MODEL1310110061#
modifier: MODEL1310110061#
reversible: true
reactant: MODEL1310110061#
kinetic law: MODEL1310110061#
is version of: http://identifiers.org/ec-code/1.1.1.27
name: L-lactate dehydrogenase

metaR GLCURtly
reversible: true
is described by: ECO:0000269
modifier: MODEL1310110061#
reactant: MODEL1310110061#
is: SBO:0000185
kinetic law: MODEL1310110061#
product: MODEL1310110061#
type: Reaction
fast: false
notes: GENE_ASSOCIATION: (26503.1) SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 4 AUTHORS: PMID:10581036,PMID:2768261 NOTES:H symport into lysososome. See PMID: 2768261 and PMID: 10581036 ( for human evidence). Sialic acid storage disorders (due to transporter mutations) require import and export e.g. PMID: 2768266 NJ renamed from GLCURlt to GLCURtly - NCD
name: glucuronate transport into lysososme

metaR HAtly
fast: false
is: SBO:0000185
reversible: false
kinetic law: MODEL1310110061#
product: MODEL1310110061#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD
type: Reaction
name: hyaluronan transport, extracellular to lysosome
reactant: MODEL1310110061#
is described by: ECO:0000000

metaR r1568
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
type: Reaction
product: MODEL1310110061#
kinetic law: MODEL1310110061#
fast: false
reactant: MODEL1310110061#
is: SBO:0000185
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110061#_aad4b9d4_e8d0_4258_b749_3d345b1b21e9
is: Q9ULD0
initial concentration: NaN
constant: false
type: Species
is encoded by: hsa:55753
is: SBO:0000252
name: OGDHL
has only substance units: false
boundary condition: true
initial amount: NaN

metaM 3dhguln c
initial amount: NaN
notes: FORMULA: C6H9O7 CHARGE: -1 INCHI: InChI=1S/C6H10O7/c7-1-2(8)3(9)4(10)5(11)6(12)13/h2-3,5,7-9,11H,1H2,(H,12,13)/p-1/t2-,3+,5-/m0/s1
is: CHEBI:57655
constant: false
has only substance units: false
boundary condition: false
is: SBO:0000247
is: HMDB06334
name: 3-dehydro-L-gulonate
initial concentration: 1.0
type: Species

metaM CE1926 e
has only substance units: false
initial concentration: 1.0
name: gama-carboxyethyl-hydroxychroman
constant: false
notes: FORMULA: C15H19O4 CHARGE: -1 INCHI: InChI=1/C15H20O4/c1-9-10(2)14-11(8-12(9)16)4-6-15(3,19-14)7-5-13(17)18/h8,16H,4-7H2,1-3H3,(H,17,18)/p-1 EHMN_ABBREVIATION: CE1926
type: Species
is: SBO:0000247
is: CHEBI:15748
is: HMDB00127
initial amount: NaN
boundary condition: false

metaM atp x
is: CHEBI:57299
boundary condition: false
is: SBO:0000247
name: ATP(4-)
is: C00002
is: HMDB00538
type: Species
initial concentration: 1.0
constant: false
initial amount: NaN
has only substance units: false

metaR TYRTAm
kinetic law: MODEL1310110061#
modifier: MODEL1310110061#
fast: false
reactant: MODEL1310110061#
is version of: http://identifiers.org/ec-code/2.6.1.1
name: tyrosine transaminase, mitochondrial
notes: GENE_ASSOCIATION: (6898.1) or (2806.1) SUBSYSTEM: Tyrosine metabolism EC Number: 2.6.1.5 Confidence Level: 4 AUTHORS: PMID:1973834 NOTES:NCD
product: MODEL1310110061#
is: SBO:0000176
is described by: ECO:0000269
reversible: true
is version of: http://identifiers.org/ec-code/2.6.1.5
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110061#_f1d07b59_374d_4c8c_b4ea_05bf4381d680
name: PNP
type: Species
is: P00491
boundary condition: true
has only substance units: false
initial concentration: NaN
initial amount: NaN
constant: false
is encoded by: hsa:4860
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110061#_3331abc8_ea02_4a4e_bede_ed66a30e477e
boundary condition: true
initial amount: NaN
initial concentration: NaN
name: SLC25A26
type: Species
is: F8WAB8
is encoded by: hsa:115286
constant: false
has only substance units: false
is: SBO:0000252

metaM fucgalacglcgalgluside hs g
type: Species
is: HMDB01167
notes: FORMULA: C50H89N2O26FULLRCO CHARGE: 0
boundary condition: false
is: SBO:0000247
has only substance units: false
initial amount: NaN
is: CHEBI:17158
name: Type IH glycolipid
constant: false
initial concentration: 1.0

metaR DM pmtcoa LPAREN r RPAREN
kinetic law: MODEL1310110061#
reactant: MODEL1310110061#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 0 AUTHORS: PMID: 17173541 NOTES:added during gap-filling, no evidence for such a reaction. only assumed.
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: demand reaction for pmtcoa
type: Reaction

metaM ksii core2 deg1 l
initial amount: NaN
notes: FORMULA: C70H113N5O59S3X CHARGE: -3
initial concentration: 1.0
is: SBO:0000247
has only substance units: false
constant: false
is: CHEBI:57737
type: Species
is: HMDB00868
boundary condition: false
name: keratan sulfate II (core 2-linked), degradation product 1

metaR PSFLIPm
is version of: http://identifiers.org/ec-code/3.6.3.1
notes: GENE_ASSOCIATION: (10396.1) or (57194.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:10198212,PMID:10856717,PMID:11353404 NOTES:See PMID: 10856717 - flippase activity no detailed data on which compartment ATP hydrolysis occurs, so for the time being assumed to be cytosolic NJ
modifier: MODEL1310110061#
reactant: MODEL1310110061#
fast: false
is: SBO:0000185
type: Reaction
name: phosphatidylserine flippase
is described by: ECO:0000269
reversible: false
kinetic law: MODEL1310110061#
product: MODEL1310110061#

metaM udp g
is: HMDB00295
is: SBO:0000247
initial amount: NaN
has only substance units: false
initial concentration: 1.0
notes: FORMULA: C9H11N2O12P2 CHARGE: -3 INCHI: InChI=1S/C9H14N2O12P2/c12-5-1-2-11(9(15)10-5)8-7(14)6(13)4(22-8)3-21-25(19,20)23-24(16,17)18/h1-2,4,6-8,13-14H,3H2,(H,19,20)(H,10,12,15)(H2,16,17,18)/p-3/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00025 EHMN_ABBREVIATION: C00015
constant: false
is: CHEBI:58223
boundary condition: false
type: Species
name: UDP(3-)

metaR CRVNCtr
reactant: MODEL1310110061#
reversible: true
is described by: ECO:0000000
is: SBO:0000185
name: fatty acid transport via diffusion
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11788354,PMID:12864740 NOTES:NJ
product: MODEL1310110061#
type: Reaction
kinetic law: MODEL1310110061#

metaM HC01180 c
initial amount: NaN
name: D-tagatofuranose 1,6-bisphosphate(4-)
boundary condition: false
has only substance units: false
initial concentration: 1.0
notes: FORMULA: C6H10O12P2 CHARGE: -4 INCHI: InChI=1S/C6H14O12P2/c7-4-3(1-16-19(10,11)12)18-6(9,5(4)8)2-17-20(13,14)15/h3-5,7-9H,1-2H2,(H2,10,11,12)(H2,13,14,15)/p-4/t3-,4+,5+,6?/m1/s1 EHMN_ABBREVIATION: C03785
is: SBO:0000247
constant: false
type: Species
is: CHEBI:58694

http://identifiers.org/biomodels.db/MODEL1310110061#_6a296bc5_858e_4831_8491_a491fb1a6ae8
is: P00505
has only substance units: false
initial amount: NaN
is encoded by: hsa:2806
name: GOT2
is: SBO:0000252
type: Species
boundary condition: true
initial concentration: NaN
constant: false

metaR FAOXC122m
kinetic law: MODEL1310110061#
product: MODEL1310110061#
reactant: MODEL1310110061#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: isomerization(C12:2)m
type: Reaction

metaM 2c23dh56dhoxin c
type: Species
name: 2-Carboxy-2,3-dihydro-5,6-dihydroxyindole
is: HMDB04067
initial concentration: 1.0
is: http://identifiers.org/pubchem.compound/7927
boundary condition: false
constant: false
initial amount: NaN
has only substance units: false
is: C05604
is: SBO:0000247
notes: FORMULA: C9H8NO4 CHARGE: -1 INCHI: InChI=1/C9H9NO4/c11-7-2-4-1-6(9(13)14)10-5(4)3-8(7)12/h2-3,6,10-12H,1H2,(H,13,14)/t6-/m0/s1 EHMN_ABBREVIATION: C05604

metaM c226coa c
notes: FORMULA: C43H62N7O17P3S CHARGE: -4 INCHI: InChI=1/C43H66N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-34(52)71-27-26-45-33(51)24-25-46-41(55)38(54)43(2,3)29-64-70(61,62)67-69(59,60)63-28-32-37(66-68(56,57)58)36(53)42(65-32)50-31-49-35-39(44)47-30-48-40(35)50/h5-6,8-9,11-12,14-15,17-18,20-21,30-32,36-38,42,53-54H,4,7,10,13,16,19,22-29H2,1-3H3,(H,45,51)(H,46,55)(H,59,60)(H,61,62)(H2,44,47,48)(H2,56,57,58)/b6-5-,9-8-,12-11-,15-14-,18-17-,21-20-/t32-,36-,37-,38?,42-/m1/s1
constant: false
name: cervonyl coenzyme A
is: http://identifiers.org/pubchem.compound/47205479
initial amount: NaN
is: SBO:0000247
type: Species
has only substance units: false
initial concentration: 1.0
boundary condition: false
is: C16169

metaR RE0830N
reversible: true
modifier: MODEL1310110061#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/4.2.1.96
reactant: MODEL1310110061#
type: Reaction
product: MODEL1310110061#
fast: false
name: RE0830
notes: GENE_ASSOCIATION: (5092.1) or (84105.1) SUBSYSTEM: Tetrahydrobiopterin metabolism EC Number: 4.2.1.96 Confidence Level: 0 AUTHORS: PMID:10727395,PMID:1355046,PMID:1988938 NOTES:
is described by: ECO:0000000
kinetic law: MODEL1310110061#

metaM ctp n
boundary condition: false
constant: false
type: Species
is: CHEBI:37563
has only substance units: false
is: HMDB00082
is: SBO:0000247
name: CTP(4-)
initial concentration: 1.0
initial amount: NaN
notes: FORMULA: C9H12N3O14P3 CHARGE: -4 INCHI: InChI=1S/C9H16N3O14P3/c10-5-1-2-12(9(15)11-5)8-7(14)6(13)4(24-8)3-23-28(19,20)26-29(21,22)25-27(16,17)18/h1-2,4,6-8,13-14H,3H2,(H,19,20)(H,21,22)(H2,10,11,15)(H2,16,17,18)/p-4/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00066 EHMN_ABBREVIATION: C00063

metaM 5mthf c
has only substance units: false
initial concentration: 1.0
boundary condition: false
is: C00440
name: 5-Methyltetrahydrofolate
type: Species
is: CHEBI:3729
initial amount: NaN
constant: false
is: SBO:0000247
is: HMDB01396
notes: FORMULA: C20H24N7O6 CHARGE: -1

metaR Htx
is described by: ECO:0000000
name: H transporter, peroxisome
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 0 AUTHORS: NOTES:diffusion NJ
fast: false
reversible: true
kinetic law: MODEL1310110061#
product: MODEL1310110061#
type: Reaction
reactant: MODEL1310110061#

metaM HC02214 e
constant: false
initial concentration: 1.0
name: prostaglandin-f1alpha
is: SBO:0000247
notes: FORMULA: C20H35O5 CHARGE: -1 INCHI: InChI=1S/C20H36O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h12-13,15-19,21-23H,2-11,14H2,1H3,(H,24,25)/b13-12+/t15-,16+,17+,18-,19+/m0/s1
initial amount: NaN
has only substance units: false
type: Species
boundary condition: false
is: CHEBI:28852

metaR TETPENT6t
reversible: true
kinetic law: MODEL1310110061#
type: Reaction
fast: false
reactant: MODEL1310110061#
product: MODEL1310110061#
is described by: ECO:0000000
name: fatty acid transport via diffusion
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11788354,PMID:12864740 NOTES:NJ
is: SBO:0000185

metaM ala L e
name: L-alanine
initial amount: NaN
boundary condition: false
is: SBO:0000247
is: HMDB00161
type: Species
notes: FORMULA: C3H7NO2 CHARGE: 0 INCHI: InChI=1S/C3H7NO2/c1-2(4)3(5)6/h2H,4H2,1H3,(H,5,6)/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00048
constant: false
initial concentration: 1.0
has only substance units: false
is: CHEBI:16977

http://identifiers.org/biomodels.db/MODEL1310110061#_f568a051_5994_4467_aa1c_e504f4f172e0
is: P49753
is: SBO:0000252
name: ACOT2
has only substance units: false
constant: false
boundary condition: true
initial concentration: NaN
is encoded by: hsa:10965
initial amount: NaN
type: Species

metaM udpacgal l
is: CHEBI:57847
is: SBO:0000247
is: HMDB00304
constant: false
type: Species
boundary condition: false
initial amount: NaN
has only substance units: false
name: UDP-N-acetyl-D-galactosamine(2-)
notes: FORMULA: C17H25N3O17P2 CHARGE: -2 INCHI: InChI=1S/C17H27N3O17P2/c1-6(22)18-10-13(26)11(24)7(4-21)35-16(10)36-39(31,32)37-38(29,30)33-5-8-12(25)14(27)15(34-8)20-3-2-9(23)19-17(20)28/h2-3,7-8,10-16,21,24-27H,4-5H2,1H3,(H,18,22)(H,29,30)(H,31,32)(H,19,23,28)/p-2/t7-,8-,10-,11+,12-,13-,14-,15-,16?/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00190 EHMN_ABBREVIATION: C00203
initial concentration: 1.0

metaM 2oxoadp c
has only substance units: false
is: CHEBI:57499
constant: false
notes: FORMULA: C6H6O5 CHARGE: -2 INCHI: InChI=1S/C6H8O5/c7-4(6(10)11)2-1-3-5(8)9/h1-3H2,(H,8,9)(H,10,11)/p-2 HEPATONET_1.0_ABBREVIATION: HC00273 EHMN_ABBREVIATION: C00322
is: SBO:0000247
boundary condition: false
initial amount: NaN
is: HMDB00225
initial concentration: 1.0
name: 2-oxoadipate(2-)
type: Species

metaR ST6GALNAC21
kinetic law: MODEL1310110061#
modifier: MODEL1310110061#
is version of: http://identifiers.org/ec-code/2.4.99.7
is: SBO:0000176
reactant: MODEL1310110061#
name: Alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2
reversible: false
notes: GENE_ASSOCIATION: (10610.1) SUBSYSTEM: Sphingolipid metabolism EC Number: 2.4.99.7 Confidence Level: 2 AUTHORS: NOTES:NJ
fast: false
is described by: ECO:0000304
type: Reaction
product: MODEL1310110061#

metaR SGPL12r
is version of: http://identifiers.org/ec-code/4.1.2.27
type: Reaction
name: Sphingosine-1-phosphate lyase
is described by: ECO:0000304
product: MODEL1310110061#
is: SBO:0000176
reversible: false
reactant: MODEL1310110061#
notes: GENE_ASSOCIATION: (8879.1) SUBSYSTEM: Sphingolipid metabolism EC Number: 4.1.2.27 Confidence Level: 2 AUTHORS: PMID:11018465,PMID:14570870 NOTES:SGPL1 gene as per GeneCards states that hexadecanal is produced - the only way to do this and to maintain charge balance would be to have H2 gas as substrate - remarkably implausible. Due to lack of information to indicate otherwise, added water to breakdown components into ethamp and palmitate NJ
kinetic law: MODEL1310110061#
modifier: MODEL1310110061#
fast: false

http://identifiers.org/biomodels.db/MODEL1310110061#_1995a960_c76f_41cd_b739_aa7480c1d34f
constant: false
is encoded by: hsa:AI697028
initial amount: NaN
name: _AI697028_1_e
is: SBO:0000252
type: Species
has only substance units: false
initial concentration: NaN
boundary condition: true

metaM inost c
has only substance units: false
constant: false
type: Species
initial concentration: 1.0
boundary condition: false
initial amount: NaN
name: myo-inositol
is: SBO:0000247
notes: FORMULA: C6H12O6 CHARGE: 0 INCHI: InChI=1S/C6H12O6/c7-1-2(8)4(10)6(12)5(11)3(1)9/h1-12H/t1-,2-,3-,4+,5-,6- HEPATONET_1.0_ABBREVIATION: HC00135 EHMN_ABBREVIATION: C00137
is: HMDB00211
is: CHEBI:17268

metaR FORtr
is: SBO:0000185
fast: false
product: MODEL1310110061#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: NOTES:diffusion NJ
is described by: ECO:0000000
reversible: true
kinetic law: MODEL1310110061#
reactant: MODEL1310110061#
type: Reaction
name: FOR transporter, endoplasmic reticulum

http://identifiers.org/biomodels.db/MODEL1310110061#_44380aee_5656_4f4e_ab97_71d14ae1dbe0
has only substance units: false
boundary condition: true
name: AOX1
is: SBO:0000252
constant: false
initial concentration: NaN
is encoded by: hsa:316
type: Species
initial amount: NaN
is: Q06278

http://identifiers.org/biomodels.db/MODEL1310110061#_59fd413b_7320_4a9f_b55a_4a29bc342387
is: Q9UG56
constant: false
initial concentration: NaN
name: PISD
type: Species
has only substance units: false
is encoded by: hsa:23761
initial amount: NaN
boundary condition: true
is: SBO:0000252

metaR r1862
name: Y+LAT2 Utilized transport
modifier: MODEL1310110061#
reversible: false
fast: false
type: Reaction
kinetic law: MODEL1310110061#
reactant: MODEL1310110061#
is described by: ECO:0000000
product: MODEL1310110061#
is: SBO:0000185
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:

metaR B3GNT51g
reversible: false
is: SBO:0000176
reactant: MODEL1310110061#
name: UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 5
product: MODEL1310110061#
kinetic law: MODEL1310110061#
type: Reaction
fast: false
modifier: MODEL1310110061#
is described by: ECO:0000304
notes: GENE_ASSOCIATION: (84002.1) SUBSYSTEM: Blood group synthesis EC Number: Confidence Level: 2 AUTHORS: NOTES:NJ

ORG:
  orgname: University of Manchester
n:
  given: Neil
  family: Swainston

metaM dpcoa e
is: C00882
has only substance units: false
is: CHEBI:57328
type: Species
name: Dephospho-CoA
boundary condition: false
initial amount: NaN
initial concentration: 1.0
is: SBO:0000247
is: HMDB01373
notes: FORMULA: C21H33N7O13P2S CHARGE: -2
constant: false

metaM dadp n
notes: FORMULA: C10H12N5O9P2 CHARGE: -3 INCHI: InChI=1S/C10H15N5O9P2/c11-9-8-10(13-3-12-9)15(4-14-8)7-1-5(16)6(23-7)2-22-26(20,21)24-25(17,18)19/h3-7,16H,1-2H2,(H,20,21)(H2,11,12,13)(H2,17,18,19)/p-3/t5-,6+,7+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00192 EHMN_ABBREVIATION: C00206
type: Species
is: CHEBI:57667
is: SBO:0000247
constant: false
boundary condition: false
has only substance units: false
is: HMDB01508
initial concentration: 1.0
initial amount: NaN
name: dADP(3-)

metaM met L c
boundary condition: false
notes: FORMULA: C5H11NO2S CHARGE: 0 INCHI: InChI=1S/C5H11NO2S/c1-9-3-2-4(6)5(7)8/h4H,2-3,6H2,1H3,(H,7,8)/t4-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00075
type: Species
constant: false
is: CHEBI:16643
name: L-methionine
is: HMDB00696
is: SBO:0000247
has only substance units: false
initial concentration: 1.0
initial amount: NaN

metaM sphs1p r
is: SBO:0000247
is: CHEBI:60119
constant: false
name: sphingosine 1-phosphate(1-)
type: Species
has only substance units: false
boundary condition: false
initial concentration: 1.0
is: HMDB00277
notes: FORMULA: C18H37NO5P CHARGE: -1 INCHI: InChI=1S/C18H38NO5P/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-18(20)17(19)16-24-25(21,22)23/h14-15,17-18,20H,2-13,16,19H2,1H3,(H2,21,22,23)/p-1/b15-14+/t17-,18+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01702 EHMN_ABBREVIATION: C06124
initial amount: NaN

metaM paf hs e
name: 1-alkyl 2-acteylglycerol 3-phosphocholine
boundary condition: false
constant: false
initial concentration: 1.0
notes: FORMULA: C11H23O4NPFULLRCO2 CHARGE: 0
has only substance units: false
initial amount: NaN
is: SBO:0000247
is: CHEBI:36707
type: Species

metaR NAGLCAly
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Keratan sulfate degradation EC Number: Confidence Level: 1 AUTHORS: NOTES:EC 3.2.1.- This reaction is my best guess at how the GlcNAc-beta-1,6-GalNAc linkage is cleaved. NCD
is: SBO:0000176
reactant: MODEL1310110061#
is described by: ECO:0000000
kinetic law: MODEL1310110061#
name: N-acetylglucosaminidase, lysosomal
product: MODEL1310110061#
type: Reaction
reversible: false

metaR B3GNT39g
reversible: false
type: Reaction
fast: false
notes: GENE_ASSOCIATION: (10331.1) SUBSYSTEM: Sphingolipid metabolism EC Number: Confidence Level: 4 AUTHORS: NOTES:NJ
reactant: MODEL1310110061#
kinetic law: MODEL1310110061#
is described by: ECO:0000000
name: UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 3, Golgi apparatus
is: SBO:0000176
product: MODEL1310110061#
modifier: MODEL1310110061#

metaR FALDH
product: MODEL1310110061#
is: SBO:0000176
reactant: MODEL1310110061#
modifier: MODEL1310110061#
is described by: ECO:0000269
kinetic law: MODEL1310110061#
notes: GENE_ASSOCIATION: (128.1) SUBSYSTEM: Tyrosine metabolism EC Number: 1.2.1.1 Confidence Level: 4 AUTHORS: PMID:4436331,PMID:8460164 NOTES:NCD
type: Reaction
fast: false
name: formaldehyde dehydrogenase
reversible: true
is version of: http://identifiers.org/ec-code/1.1.1.1

http://identifiers.org/biomodels.db/MODEL1310110061#_a1fc856a_b38c_4134_be1f_4efe5e62602a
initial amount: NaN
constant: false
initial concentration: NaN
is encoded by: hsa:5295
boundary condition: true
is: B3KT19
is: SBO:0000252
type: Species
has only substance units: false
name: PIK3R1

metaR TKT1
reactant: MODEL1310110061#
kinetic law: MODEL1310110061#
modifier: MODEL1310110061#
is version of: http://identifiers.org/ec-code/2.2.1.1
is: SBO:0000176
notes: GENE_ASSOCIATION: (7086.1) or (84076.1) or (8277.1) SUBSYSTEM: Pentose phosphate pathway EC Number: 2.2.1.1 Confidence Level: 0 AUTHORS: NOTES:SMP Two reactions for transketolase: TKT1 and TKT2
is described by: ECO:0000000
product: MODEL1310110061#
type: Reaction
fast: false
reversible: true
name: transketolase

http://identifiers.org/biomodels.db/MODEL1310110061#_e832e766_7b14_404b_8598_deac3a3f2247
has only substance units: false
is encoded by: hsa:AA177072
constant: false
is: SBO:0000252
initial amount: NaN
initial concentration: NaN
type: Species
boundary condition: true
name: _AA177072_1_c

metaR EX Rtotal3 LPAREN e RPAREN
kinetic law: MODEL1310110061#
reactant: MODEL1310110061#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: R total 3 position exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110061#_eefc1142_3a18_424e_9237_2e33bc719dc7
constant: false
type: Species
boundary condition: true
initial amount: NaN
has only substance units: false
is: Q63HM1
name: AFMID
is: SBO:0000252
initial concentration: NaN
is encoded by: hsa:125061

metaR G3PD1
is version of: http://identifiers.org/ec-code/1.1.1.8
is: SBO:0000176
name: glycerol-3-phosphate dehydrogenase (NAD)
reversible: true
modifier: MODEL1310110061#
notes: GENE_ASSOCIATION: (2819.1) SUBSYSTEM: Glycerophospholipid metabolism EC Number: 1.1.1.94 Confidence Level: 4 AUTHORS: PMID:11385633,PMID:7772607 NOTES:NAD-specific; see also G3PD2
is described by: ECO:0000269
type: Reaction
kinetic law: MODEL1310110061#
reactant: MODEL1310110061#
product: MODEL1310110061#
fast: false

metaR FAOXC205C185m
kinetic law: MODEL1310110061#
product: MODEL1310110061#
reactant: MODEL1310110061#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C20:5-->C18:5)m
type: Reaction

metaR r0679
notes: GENE_ASSOCIATION: (30.1) or (10449.1) or (3032.1) or (4645.1) SUBSYSTEM: CoA catabolism EC Number: 2.7.1.33 Confidence Level: 0 AUTHORS: PMID:10625688,PMID:13630913,PMID:15105273,PMID:15659606,PMID:16040613 NOTES:
product: MODEL1310110061#
type: Reaction
is version of: http://identifiers.org/ec-code/2.3.1.16
reactant: MODEL1310110061#
is described by: ECO:0000000
name: ATP:pantothenate 4-phosphotransferase Pantothenate and CoA biosynthesis EC:2.7.1.33
is: SBO:0000176
reversible: true
modifier: MODEL1310110061#
kinetic law: MODEL1310110061#
fast: false

metaR CERT1gt
is: SBO:0000185
reactant: MODEL1310110061#
is described by: ECO:0000304
modifier: MODEL1310110061#
name: ceramide transport protein
kinetic law: MODEL1310110061#
product: MODEL1310110061#
is version of: http://identifiers.org/ec-code/2.7.11.1
notes: GENE_ASSOCIATION: (10087.1) SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 2 AUTHORS: PMID:12803919,PMID:14685229,PMID:15596449,PMID:15907394 NOTES:non-vesicular intracellular transport of ceramide
type: Reaction
reversible: true
fast: false

metaR r0407
type: Reaction
is described by: ECO:0000000
reversible: true
product: MODEL1310110061#
is: SBO:0000176
modifier: MODEL1310110061#
fast: false
name: Sedoheptulose 1,7-bisphosphate D-glyceraldehyde-3-phosphate-lyase Carbon fixation EC:4.1.2.13
notes: GENE_ASSOCIATION: (AI934540.1) or (55163.1) or (W74642.1) SUBSYSTEM: Unassigned EC Number: 4.1.2.13 Confidence Level: 0 AUTHORS: PMID:10214945,PMID:2198022,PMID:4052378,PMID:4084320,PMID:6952783 NOTES:
kinetic law: MODEL1310110061#
reactant: MODEL1310110061#
is version of: http://identifiers.org/ec-code/1.4.3.5

metaR Htr
product: MODEL1310110061#
reversible: true
reactant: MODEL1310110061#
kinetic law: MODEL1310110061#
is described by: ECO:0000000
name: H transporter, endoplasmic reticulum
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: NOTES:diffusion NJ
is: SBO:0000185
type: Reaction

metaM tddedicoa m
notes: FORMULA: C33H50N7O17P3S CHARGE: -4
initial amount: NaN
type: Species
is: http://identifiers.org/pubchem.compound/5280771
initial concentration: 1.0
has only substance units: false
is: SBO:0000247
constant: false
name: trans3,6dodecadienoylcoa
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110061#_b1726431_e534_4498_925d_a9d42fb42a06
initial concentration: NaN
is: B7Z7I0
name: TKTL1
initial amount: NaN
has only substance units: false
is encoded by: hsa:8277
is: SBO:0000252
constant: false
boundary condition: true
type: Species

metaM acglcgalgluside hs g
notes: FORMULA: C38H69N2O17FULLRCO CHARGE: 0
has only substance units: false
is: CHEBI:17103
constant: false
name: N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosylceramide
initial amount: NaN
is: SBO:0000247
boundary condition: false
type: Species
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110061#_6fdb90f7_4204_4126_9d7b_3665cae32df3
initial amount: NaN
constant: false
initial concentration: NaN
is: Q96CD2
is encoded by: hsa:60490
name: PPCDC
type: Species
has only substance units: false
boundary condition: true
is: SBO:0000252

metaM CE4792 m
name: 3-oxo-cis-8-tetradecenoyl-CoA
constant: false
type: Species
boundary condition: false
is: CHEBI:57923
initial amount: NaN
initial concentration: 1.0
notes: FORMULA: C35H54N7O18P3S CHARGE: -4 INCHI: InChI=1/C35H58N7O18P3S/c1-4-5-6-7-8-9-10-11-12-13-23(43)18-26(45)64-17-16-37-25(44)14-15-38-33(48)30(47)35(2,3)20-57-63(54,55)60-62(52,53)56-19-24-29(59-61(49,50)51)28(46)34(58-24)42-22-41-27-31(36)39-21-40-32(27)42/h8-9,21-22,24,28-30,34,46-47H,4-7,10-20H2,1-3H3,(H,37,44)(H,38,48)(H,52,53)(H,54,55)(H2,36,39,40)(H2,49,50,51)/p-4/b9-8-/t24-,28+,29+,30u,34-/m0/s1 EHMN_ABBREVIATION: CE4792
is: SBO:0000247
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110061#_8f043c37_970e_40d4_96b8_795265aac807
initial concentration: NaN
is: SBO:0000252
type: Species
is encoded by: hsa:222
is: P48448
name: ALDH3B2
initial amount: NaN
boundary condition: true
has only substance units: false
constant: false

metaM dhap c
boundary condition: false
is: CHEBI:57642
is: C00111
constant: false
is: HMDB01473
initial amount: NaN
initial concentration: 1.0
type: Species
is: http://identifiers.org/pubchem.compound/3411
is: SBO:0000247
name: Dihydroxyacetone phosphate
has only substance units: false

metaM lpchol hs e
initial amount: NaN
is: SBO:0000247
boundary condition: false
name: lysophosphatidylcholine
type: Species
initial concentration: 1.0
has only substance units: false
constant: false
is: CHEBI:60479
notes: FORMULA: C8H19NO5PFULLRCO2 CHARGE: 0

metaR DCSPTN1CPT1
modifier: MODEL1310110061#
name: carnitine O-palmitoyltransferase
is version of: http://identifiers.org/ec-code/2.3.1.21
notes: GENE_ASSOCIATION: (1375.1) or (1375.3) or (1375.4) or (126129.1) or (1374.1) or (1375.2) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.21 Confidence Level: 4 AUTHORS: NOTES:NJ
reactant: MODEL1310110061#
fast: false
product: MODEL1310110061#
is described by: ECO:0000269
type: Reaction
is: SBO:0000176
kinetic law: MODEL1310110061#
reversible: false

metaR r0472
reversible: true
is described by: ECO:0000000
is: SBO:0000176
name: 2-Deoxyadenosine 5-diphosphate:oxidized-thioredoxin 2-oxidoreductase Purine metabolism EC:1.17.4.1
notes: GENE_ASSOCIATION: SUBSYSTEM: Nucleotide interconversion EC Number: 1.17.4.1 Confidence Level: 0 AUTHORS: PMID:6121703,PMID:8074691 NOTES:
kinetic law: MODEL1310110061#
type: Reaction
product: MODEL1310110061#
fast: false
reactant: MODEL1310110061#

http://identifiers.org/biomodels.db/MODEL1310110061#_abf3ac8f_ebaa_4846_973e_cdb651d4c661
is: SBO:0000252
constant: false
name: TXNRD2
boundary condition: true
initial amount: NaN
type: Species
has only substance units: false
initial concentration: NaN
is encoded by: hsa:10587

http://identifiers.org/biomodels.db/MODEL1310110061#_292d830f_acb0_48f6_b3cb_6a7022cf69fc
type: Species
initial concentration: NaN
name: LDHC
is: SBO:0000252
has only substance units: false
is encoded by: hsa:3948
initial amount: NaN
boundary condition: true
is: P07864
constant: false

metaM glu L e
type: Species
boundary condition: false
is: CHEBI:29985
constant: false
is: SBO:0000247
name: L-glutamate(1-)
has only substance units: false
initial concentration: 1.0
notes: FORMULA: C5H8NO4 CHARGE: -1 INCHI: InChI=1S/C5H9NO4/c6-3(5(9)10)1-2-4(7)8/h3H,1-2,6H2,(H,7,8)(H,9,10)/p-1/t3-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00034 EHMN_ABBREVIATION: C00025
is: HMDB00148
initial amount: NaN

metaR NH4tn
product: MODEL1310110061#
is described by: ECO:0000000
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 1 AUTHORS: NOTES:IT
reversible: true
name: ammonia nuclear transport
fast: false
reactant: MODEL1310110061#
is: SBO:0000185
kinetic law: MODEL1310110061#

http://identifiers.org/biomodels.db/MODEL1310110061#_2503cd21_3447_45b0_a7c2_1899ef911bcf
initial concentration: NaN
has only substance units: false
constant: false
is encoded by: hsa:83549
is: Q5JT09
initial amount: NaN
boundary condition: true
is: SBO:0000252
name: UCK1
type: Species

metaR EX ala D LPAREN e RPAREN
kinetic law: MODEL1310110061#
reactant: MODEL1310110061#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: D-Alanine exchange
type: Reaction

metaR r0408
reactant: MODEL1310110061#
kinetic law: MODEL1310110061#
type: Reaction
is version of: http://identifiers.org/ec-code/1.4.3.5
name: ATP:Sedoheptulose 7-phosphate 1-phosphotransferase EC:2.7.1.11
is described by: ECO:0000000
fast: false
reversible: true
notes: GENE_ASSOCIATION: (AI934540.1) or (55163.1) or (W74642.1) SUBSYSTEM: Unassigned EC Number: 2.7.1.11 Confidence Level: 0 AUTHORS: PMID:4084320,PMID:4272358 NOTES:
modifier: MODEL1310110061#
product: MODEL1310110061#
is: SBO:0000176

W3 CDTF: Fri Aug 31 06:36:00 BST 2012

metaM 3sala m
initial amount: NaN
is: SBO:0000247
name: 3-sulfino-L-alanine (1-)
constant: false
type: Species
notes: FORMULA: C3H5NO4S CHARGE: -2 INCHI: InChI=1S/C3H7NO4S/c4-2(3(5)6)1-9(7)8/h2H,1,4H2,(H,5,6)(H,7,8)/p-1/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00451 EHMN_ABBREVIATION: C00606
has only substance units: false
initial concentration: 1.0
is: C00606
is: CHEBI:61085
boundary condition: false

metaM lpam m
initial concentration: 1.0
has only substance units: false
constant: false
type: Species
name: lipoamide
is: CHEBI:17460
is: HMDB00962
boundary condition: false
notes: FORMULA: C8H15NOS2 CHARGE: 0 INCHI: InChI=1S/C8H15NOS2/c9-8(10)4-2-1-3-7-5-6-11-12-7/h7H,1-6H2,(H2,9,10) HEPATONET_1.0_ABBREVIATION: HC00225 EHMN_ABBREVIATION: C00248
initial amount: NaN
is: SBO:0000247

metaM met L e
has only substance units: false
initial concentration: 1.0
type: Species
is: CHEBI:16643
boundary condition: false
notes: FORMULA: C5H11NO2S CHARGE: 0 INCHI: InChI=1S/C5H11NO2S/c1-9-3-2-4(6)5(7)8/h4H,2-3,6H2,1H3,(H,7,8)/t4-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00075
constant: false
name: L-methionine
is: HMDB00696
initial amount: NaN
is: SBO:0000247

metaR NTD6
name: 5'-nucleotidase (dAMP)
notes: GENE_ASSOCIATION: (22978.1) SUBSYSTEM: Nucleotide interconversion EC Number: 3.1.3.5 Confidence Level: 2 AUTHORS: PMID:8450671 NOTES:Wide specificity for 5'-nucleotides Also see EC 3.1.3.31
reactant: MODEL1310110061#
is version of: http://identifiers.org/ec-code/3.1.3.5
reversible: false
modifier: MODEL1310110061#
fast: false
product: MODEL1310110061#
is described by: ECO:0000134
type: Reaction
kinetic law: MODEL1310110061#
is: SBO:0000176

metaR DCSPTN1CPT2
fast: false
is version of: http://identifiers.org/ec-code/2.3.1.21
is described by: ECO:0000000
name: carnitine transferase
reactant: MODEL1310110061#
reversible: false
type: Reaction
is: SBO:0000176
product: MODEL1310110061#
notes: GENE_ASSOCIATION: (1376.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: NOTES:NJ
kinetic law: MODEL1310110061#
modifier: MODEL1310110061#

http://identifiers.org/biomodels.db/MODEL1310110061#_877a94e9_404d_471d_8e8b_9b103c3fbc21
initial concentration: NaN
name: SLC25A13
boundary condition: true
is encoded by: hsa:10165
is: SBO:0000252
has only substance units: false
initial amount: NaN
type: Species
constant: false
is: Q9UJS0

metaR DDPGAm
fast: false
name: 2-dehydro-3-deoxy-phosphogluconate aldolase, mitochondrial
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Arginine and Proline Metabolism EC Number: 4.1.2.14 Confidence Level: 2 AUTHORS: PMID:12660328,PMID:14193832,PMID:15849464,PMID:9783918 NOTES:IT rxn is done by 4.1.2.14 and 4.1.3.16 mitochondrial isozyme - NCD
reactant: MODEL1310110061#
reversible: true
kinetic law: MODEL1310110061#
is described by: ECO:0000000
product: MODEL1310110061#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110061#_b3cf8db2_e5af_4f6e_9892_77ae60d070cd
boundary condition: true
is encoded by: hsa:52
type: Species
has only substance units: false
name: ACP1
initial amount: NaN
is: Q59EH3
constant: false
is: SBO:0000252
initial concentration: NaN

metaM hexdectecoa m
has only substance units: false
is: SBO:0000247
name: 2,4,7,10-hexadecatetraenoylcoa
initial amount: NaN
type: Species
notes: FORMULA: C37H54N7O17P3S CHARGE: -4
boundary condition: false
constant: false
is: HMDB02288
initial concentration: 1.0

metaR ENGASE2ly
is described by: ECO:0000000
fast: false
type: Reaction
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: N-glycan degradation EC Number: 3.2.1.96 Confidence Level: 0 AUTHORS: NOTES:NCD
name: endo-beta-N-acetylglucosaminidase, lysosomal
kinetic law: MODEL1310110061#
product: MODEL1310110061#
reversible: false
reactant: MODEL1310110061#

metaR FAOXC226m
kinetic law: MODEL1310110061#
product: MODEL1310110061#
reactant: MODEL1310110061#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: isomerization(C22:6)m
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110061#_871e7184_568c_41a3_9c37_5f221ebaef51
has only substance units: false
boundary condition: true
initial concentration: NaN
type: Species
name: GALNS
is encoded by: hsa:2588
constant: false
initial amount: NaN
is: P34059
is: SBO:0000252

metaR r0899
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:10721894,PMID:11787643,PMID:12269802,PMID:12504794,PMID:16955229,PMID:17401668,PMID:18599538,PMID:3132542,PMID:487087,PMID:551321,PMID:6418146,PMID:7731061,PMID:8010975,PMID:8382624,PMID:8654117,PMID:8899554,PMID:911815,PMID:917262 NOTES:
fast: false
type: Reaction
reversible: true
product: MODEL1310110061#
kinetic law: MODEL1310110061#
reactant: MODEL1310110061#
name: Amino acid transporter ATB0+ Facilitated diffusion
is described by: ECO:0000000
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110061#_66e78350_b957_44c9_8c51_02e210c17b2c
is: SBO:0000252
initial concentration: NaN
boundary condition: true
initial amount: NaN
type: Species
constant: false
is encoded by: hsa:80347
name: COASY
has only substance units: false
is: Q13057

http://identifiers.org/biomodels.db/MODEL1310110061#_d2566e38_24a3_4e1e_82f9_1c56c607b73f
is: Q3KQV9
type: Species
is encoded by: hsa:91373
initial concentration: NaN
is: SBO:0000252
name: UAP1L1
constant: false
initial amount: NaN
has only substance units: false
boundary condition: true

metaM udp c
is: C00015
is: HMDB00295
name: UDP
has only substance units: false
constant: false
notes: FORMULA: C9H11N2O12P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00025 EHMN_ABBREVIATION: C00015
initial amount: NaN
type: Species
boundary condition: false
is: SBO:0000247
is: CHEBI:58223
initial concentration: 1.0

metaR r0560
reversible: false
name: 2-Methylpropanoyl-CoA:oxygen 2,3-oxidoreductase Valine, leucine and isoleucine degradation EC:1.3.99.2
notes: GENE_ASSOCIATION: SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 1.3.99.2 Confidence Level: 0 AUTHORS: PMID:12855692,PMID:3597357,PMID:6401712,PMID:6874697 NOTES:
fast: false
type: Reaction
is described by: ECO:0000000
reactant: MODEL1310110061#
product: MODEL1310110061#
kinetic law: MODEL1310110061#
is: SBO:0000176

metaM glyald c
type: Species
boundary condition: false
constant: false
initial amount: NaN
name: D-Glyceraldehyde
notes: FORMULA: C3H6O3 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00436 EHMN_ABBREVIATION: C00577
has only substance units: false
is: CHEBI:17378
is: C00577
initial concentration: 1.0
is: HMDB01051
is: SBO:0000247

metaR NTD9
type: Reaction
modifier: MODEL1310110061#
fast: false
reversible: false
is: SBO:0000176
is described by: ECO:0000134
notes: GENE_ASSOCIATION: (22978.1) SUBSYSTEM: Nucleotide interconversion EC Number: 3.1.3.5 Confidence Level: 2 AUTHORS: PMID:8450671 NOTES:Wide specificity for 5'-nucleotides Also see EC 3.1.3.31
is version of: http://identifiers.org/ec-code/3.1.3.5
reactant: MODEL1310110061#
kinetic law: MODEL1310110061#
product: MODEL1310110061#
name: 5'-nucleotidase (GMP)

metaM mi14p c
has only substance units: false
notes: FORMULA: C6H10O12P2 CHARGE: -4 INCHI: InChI=1S/C6H14O12P2/c7-1-2(8)6(18-20(14,15)16)4(10)3(9)5(1)17-19(11,12)13/h1-10H,(H2,11,12,13)(H2,14,15,16)/p-4/t1-,2-,3-,4+,5+,6+/m1/s1 EHMN_ABBREVIATION: C01220
boundary condition: false
constant: false
is: CHEBI:58282
name: (1R,2R,3R,4R,5R,6S)-2,3,5,6-tetrahydroxy-4-(phosphonatooxy)cyclohexyl phosphate
initial concentration: 1.0
type: Species
is: SBO:0000247
is: HMDB00968
initial amount: NaN

metaM thcrm hs g
is: CHEBI:24636
is: SBO:0000247
boundary condition: false
name: trihexosyl ceramide
initial concentration: 1.0
constant: false
type: Species
notes: FORMULA: C36H66NO17FULLRCO CHARGE: 0
has only substance units: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110061#_1c70d78d_0d28_42c6_b198_da5558cf2abf
is: SBO:0000252
initial amount: NaN
boundary condition: true
is encoded by: hsa:LOC374569
initial concentration: NaN
name: _LOC374569_1_e
type: Species
constant: false
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110061#_2136a658_0c40_4573_af5f_f057169922d9
name: SLC9A2
is: SBO:0000252
constant: false
has only substance units: false
initial concentration: NaN
type: Species
is encoded by: hsa:6549
is: Q9UBY0
boundary condition: true
initial amount: NaN

metaR r1147
product: MODEL1310110061#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:16919238,PMID:17173541,PMID:18406340,PMID:8132483 NOTES:
reversible: true
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
fast: false
is: SBO:0000185
kinetic law: MODEL1310110061#
is described by: ECO:0000000
type: Reaction
reactant: MODEL1310110061#

http://identifiers.org/biomodels.db/MODEL1310110061#_84915b68_64fb_4d62_99bc_f9d5098b05bb
initial concentration: NaN
type: Species
name: PCBD1
initial amount: NaN
is: P61457
constant: false
is encoded by: hsa:5092
has only substance units: false
boundary condition: true
is: SBO:0000252

metaM dhap e
is: SBO:0000247
initial amount: NaN
notes: FORMULA: C3H5O6P CHARGE: -2 INCHI: InChI=1S/C3H7O6P/c4-1-3(5)2-9-10(6,7)8/h4H,1-2H2,(H2,6,7,8)/p-2 HEPATONET_1.0_ABBREVIATION: HC00109 EHMN_ABBREVIATION: C00111
initial concentration: 1.0
constant: false
is: HMDB01473
has only substance units: false
boundary condition: false
type: Species
name: glycerone phosphate(2-)
is: CHEBI:57642

metaM lpchol hs c
is: SBO:0000247
type: Species
constant: false
initial amount: NaN
initial concentration: 1.0
notes: FORMULA: C8H19NO5PFULLRCO2 CHARGE: 0
name: lysophosphatidylcholine
boundary condition: false
has only substance units: false
is: CHEBI:60479

http://identifiers.org/biomodels.db/MODEL1310110061#_07a2f56b_f105_438d_9d24_d0bc9b2ca3ba
is: P35754
initial concentration: NaN
has only substance units: false
initial amount: NaN
name: GLRX
is encoded by: hsa:2745
boundary condition: true
is: SBO:0000252
constant: false
type: Species

W3 CDTF: Fri Aug 31 06:36:00 BST 2012

metaR r0474
reversible: true
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Nucleotide interconversion EC Number: 1.17.4.1 Confidence Level: 0 AUTHORS: PMID:6121703,PMID:8074691 NOTES:
name: 2-Deoxyadenosine 5-diphosphate:oxidized-thioredoxin 2-oxidoreductase Purine metabolism EC:1.17.4.1
kinetic law: MODEL1310110061#
product: MODEL1310110061#
is described by: ECO:0000000
fast: false
reactant: MODEL1310110061#
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110061#_b917e0a3_9cfc_4139_b7ce_6a7df2ffc939
has only substance units: false
initial concentration: NaN
is encoded by: hsa:771
name: CA12
is: SBO:0000252
initial amount: NaN
type: Species
constant: false
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110061#_f0daf4a3_2c7c_490c_8e8e_686a8eaa5466
is: E9PAY8
constant: false
name: PPAP2C
type: Species
initial concentration: NaN
boundary condition: true
has only substance units: false
initial amount: NaN
is: SBO:0000252
is encoded by: hsa:8612

metaR AHCYSte
is: SBO:0000185
reversible: true
is described by: ECO:0000134
kinetic law: MODEL1310110061#
reactant: MODEL1310110061#
type: Reaction
name: Transport of S-adenosyl-L-homocysteine
fast: false
product: MODEL1310110061#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:

metaR RE1845C
is version of: http://identifiers.org/ec-code/2.3.1.65
kinetic law: MODEL1310110061#
notes: GENE_ASSOCIATION: (570.1) SUBSYSTEM: Bile acid synthesis EC Number: 2.3.1.65 Confidence Level: 0 AUTHORS: PMID:11980911 NOTES:IT - removed 4 h[c] from compEHMN reaction as they were not necessary
fast: false
name: RE1845
type: Reaction
is described by: ECO:0000000
modifier: MODEL1310110061#
is: SBO:0000176
product: MODEL1310110061#
reactant: MODEL1310110061#
reversible: true

metaR r2009
is: SBO:0000185
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
kinetic law: MODEL1310110061#
product: MODEL1310110061#
is described by: ECO:0000000
modifier: MODEL1310110061#
reactant: MODEL1310110061#
type: Reaction
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.15
reversible: false
fast: false

http://identifiers.org/biomodels.db/MODEL1310110061#_0e923250_22b7_48ee_bf1c_8d986af72ac4
is: SBO:0000252
type: Species
name: _BE966236_1_m
boundary condition: true
constant: false
is encoded by: hsa:BE966236
has only substance units: false
initial amount: NaN
initial concentration: NaN

metaR LYStm
is described by: ECO:0000269
fast: false
is: SBO:0000185
type: Reaction
notes: GENE_ASSOCIATION: (83884.1) or (10166.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172 NOTES:TDV
modifier: MODEL1310110061#
reactant: MODEL1310110061#
kinetic law: MODEL1310110061#
reversible: true
name: Lysine mitochondrial transport via ornithine carrier
product: MODEL1310110061#

metaM glu L c
type: Species
initial amount: NaN
boundary condition: false
is: CHEBI:29985
constant: false
name: L-glutamate(1-)
has only substance units: false
initial concentration: 1.0
notes: FORMULA: C5H8NO4 CHARGE: -1 INCHI: InChI=1S/C5H9NO4/c6-3(5(9)10)1-2-4(7)8/h3H,1-2,6H2,(H,7,8)(H,9,10)/p-1/t3-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00034 EHMN_ABBREVIATION: C00025
is: SBO:0000247
is: HMDB00148

metaR EX g1p LPAREN e RPAREN
kinetic law: MODEL1310110061#
reactant: MODEL1310110061#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of alpha-D-glucose 1-phosphate(2-)
type: Reaction

metaM 3hmbcoa m
name: (2S,3S)-3-hydroxy-2-methylbutanoyl-CoA(4-)
is: CHEBI:57312
boundary condition: false
has only substance units: false
is: HMDB01356
is: SBO:0000247
constant: false
notes: FORMULA: C26H40N7O18P3S CHARGE: -4 INCHI: InChI=1S/C26H44N7O18P3S/c1-13(14(2)34)25(39)55-8-7-28-16(35)5-6-29-23(38)20(37)26(3,4)10-48-54(45,46)51-53(43,44)47-9-15-19(50-52(40,41)42)18(36)24(49-15)33-12-32-17-21(27)30-11-31-22(17)33/h11-15,18-20,24,34,36-37H,5-10H2,1-4H3,(H,28,35)(H,29,38)(H,43,44)(H,45,46)(H2,27,30,31)(H2,40,41,42)/p-4/t13-,14-,15+,18+,19+,20-,24+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01287 EHMN_ABBREVIATION: C04405
type: Species
initial amount: NaN
initial concentration: 1.0

metaR r1292
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: 6.2.1.3 Confidence Level: 0 AUTHORS: PMID:8584017 NOTES:
reversible: true
product: MODEL1310110061#
type: Reaction
is described by: ECO:0000000
reactant: MODEL1310110061#
fast: false
is: SBO:0000185
name: Postulated transport reaction
kinetic law: MODEL1310110061#

metaR NH4tp
kinetic law: MODEL1310110061#
product: MODEL1310110061#
reversible: true
name: ammonia peroxisomal transport
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD
is: SBO:0000185
reactant: MODEL1310110061#
is described by: ECO:0000000
type: Reaction

metaR EX thym LPAREN e RPAREN
kinetic law: MODEL1310110061#
reactant: MODEL1310110061#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Thymine exchange
type: Reaction

metaR r1866
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is: SBO:0000185
reactant: MODEL1310110061#
type: Reaction
is described by: ECO:0000000
product: MODEL1310110061#
name: Y+LAT2 Utilized transport
kinetic law: MODEL1310110061#
modifier: MODEL1310110061#
reversible: false
fast: false

metaR r2099
kinetic law: MODEL1310110061#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
is: SBO:0000185
reactant: MODEL1310110061#
is described by: ECO:0000000
fast: false
type: Reaction
reversible: true
modifier: MODEL1310110061#
product: MODEL1310110061#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1

metaR EX estrones LPAREN e RPAREN
kinetic law: MODEL1310110061#
reactant: MODEL1310110061#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Estrone 3-sulfate exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110061#_12b173f3_8cb5_4b7c_aa76_0b015260fb80
name: ALAS2
constant: false
initial concentration: NaN
is: Q5JZF5
is: SBO:0000252
initial amount: NaN
type: Species
has only substance units: false
is encoded by: hsa:212
boundary condition: true

metaR LEUKTRD4tr
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: NOTES:unknown mechanism, presumed diffusion NJ
is: SBO:0000185
is described by: ECO:0000000
reversible: true
reactant: MODEL1310110061#
type: Reaction
fast: false
name: leukotriene intracellular transport
kinetic law: MODEL1310110061#
product: MODEL1310110061#

metaR EX tetpent3 LPAREN e RPAREN
kinetic law: MODEL1310110061#
reactant: MODEL1310110061#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: tetracosapentaenoic acid, n-3 exchange
type: Reaction

W3 CDTF: Fri Aug 31 06:35:59 BST 2012

metaR TETTET6COAtx
is: SBO:0000185
reversible: true
product: MODEL1310110061#
fast: false
name: fatty acid intracellular transport
reactant: MODEL1310110061#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: NOTES:interaction between peroxisomes and ER (some enzymes on the outer membrane) NJ
kinetic law: MODEL1310110061#
type: Reaction
is described by: ECO:0000000

metaR r0809
notes: GENE_ASSOCIATION: (2194.1) SUBSYSTEM: Purine catabolism EC Number: Confidence Level: 0 AUTHORS: PMID:1550832,PMID:8438778 NOTES:
product: MODEL1310110061#
modifier: MODEL1310110061#
type: Reaction
reversible: true
is described by: ECO:0000000
is: SBO:0000185
is version of: http://identifiers.org/ec-code/2.3.1.85
name: Facilitated diffusion
fast: false
kinetic law: MODEL1310110061#
reactant: MODEL1310110061#

metaM HC01403 m
is: SBO:0000247
name: (S)-Hydroxydecanoyl-CoA
initial concentration: 1.0
constant: false
boundary condition: false
is: CHEBI:28325
notes: FORMULA: C31H50N7O18P3S CHARGE: -4 INCHI: InChI=1S/C31H54N7O18P3S/c1-4-5-6-7-8-9-19(39)14-22(41)60-13-12-33-21(40)10-11-34-29(44)26(43)31(2,3)16-53-59(50,51)56-58(48,49)52-15-20-25(55-57(45,46)47)24(42)30(54-20)38-18-37-23-27(32)35-17-36-28(23)38/h17-20,24-26,30,39,42-43H,4-16H2,1-3H3,(H,33,40)(H,34,44)(H,48,49)(H,50,51)(H2,32,35,36)(H2,45,46,47)/t19-,20+,24+,25+,26-,30+/m0/s1 EHMN_ABBREVIATION: C05264
has only substance units: false
initial amount: NaN
type: Species

metaR AHCYStd
product: MODEL1310110061#
is described by: ECO:0000134
reversible: true
fast: false
kinetic law: MODEL1310110061#
reactant: MODEL1310110061#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID: 8283303. NOTES:
type: Reaction
is: SBO:0000185
name: diffusion of S-Adenosyl-L-homocysteine

metaR EX acac LPAREN e RPAREN
kinetic law: MODEL1310110061#
reactant: MODEL1310110061#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Acetoacetate exchange
type: Reaction

metaR GMAND
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (2762.1) SUBSYSTEM: Fructose and mannose metabolism EC Number: 4.2.1.47 Confidence Level: 0 AUTHORS: NOTES:JLR
reversible: false
kinetic law: MODEL1310110061#
product: MODEL1310110061#
fast: false
modifier: MODEL1310110061#
is version of: http://identifiers.org/ec-code/4.2.1.47
type: Reaction
name: GDP-D-mannose dehydratase
is: SBO:0000176
reactant: MODEL1310110061#

metaR FAOXC101C102m
kinetic law: MODEL1310110061#
product: MODEL1310110061#
reactant: MODEL1310110061#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C10:1-->C10:2)m
type: Reaction

metaR r1291
type: Reaction
name: Postulated transport reaction
is described by: ECO:0000000
reversible: true
reactant: MODEL1310110061#
fast: false
product: MODEL1310110061#
kinetic law: MODEL1310110061#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: 6.2.1.3 Confidence Level: 0 AUTHORS: PMID:8584017 NOTES:
is: SBO:0000185

metaR DCYTDn
is described by: ECO:0000254
reversible: false
reactant: MODEL1310110061#
fast: false
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.5.4.5
kinetic law: MODEL1310110061#
modifier: MODEL1310110061#
notes: GENE_ASSOCIATION: (57379.1) SUBSYSTEM: Nucleotide interconversion EC Number: 3.5.4.14 Confidence Level: 2 AUTHORS: PMID:15087440 NOTES:IT
product: MODEL1310110061#
type: Reaction
name: deoxycytidine deaminase, nuclear

http://identifiers.org/biomodels.db/MODEL1310110061#_ef086e17_e48e_4f7e_acb3_b407d466187f
boundary condition: true
is: P07195
is encoded by: hsa:3945
type: Species
initial amount: NaN
name: LDHB
is: SBO:0000252
has only substance units: false
constant: false
initial concentration: NaN

metaM tmndnccoa c
name: timnodonyl coenzyme A
is: SBO:0000247
constant: false
boundary condition: false
initial amount: NaN
is: HMDB06514
has only substance units: false
type: Species
notes: FORMULA: C41H60N7O17P3S CHARGE: -4 INCHI: InChI=1/C41H64N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-32(50)69-25-24-43-31(49)22-23-44-39(53)36(52)41(2,3)27-62-68(59,60)65-67(57,58)61-26-30-35(64-66(54,55)56)34(51)40(63-30)48-29-47-33-37(42)45-28-46-38(33)48/h5-6,8-9,11-12,14-15,17-18,28-30,34-36,40,51-52H,4,7,10,13,16,19-27H2,1-3H3,(H,43,49)(H,44,53)(H,57,58)(H,59,60)(H2,42,45,46)(H2,54,55,56)/b6-5-,9-8-,12-11-,15-14-,18-17-/t30-,34-,35?,36+,40-/m1/s1
initial concentration: 1.0

metaM udp e
initial concentration: 1.0
is: HMDB00295
name: UDP(3-)
constant: false
notes: FORMULA: C9H11N2O12P2 CHARGE: -3 INCHI: InChI=1S/C9H14N2O12P2/c12-5-1-2-11(9(15)10-5)8-7(14)6(13)4(22-8)3-21-25(19,20)23-24(16,17)18/h1-2,4,6-8,13-14H,3H2,(H,19,20)(H,10,12,15)(H2,16,17,18)/p-3/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00025 EHMN_ABBREVIATION: C00015
initial amount: NaN
has only substance units: false
is: SBO:0000247
type: Species
boundary condition: false
is: CHEBI:58223

http://identifiers.org/biomodels.db/MODEL1310110061#_540246ed_44b6_4733_ad7d_375acc54cb6f
initial concentration: NaN
name: AMD1
boundary condition: true
constant: false
type: Species
is: SBO:0000252
is encoded by: hsa:262
has only substance units: false
is: P17707
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110061#_69140cbf_5dd6_461b_80e3_9b810271bd66
type: Species
is encoded by: hsa:2571
initial concentration: NaN
is: SBO:0000252
is: Q99259
constant: false
has only substance units: false
name: GAD1
boundary condition: true
initial amount: NaN

metaR r0670
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 1.2.4.4 Confidence Level: 0 AUTHORS: PMID:11839747,PMID:12387880,PMID:15576032 NOTES:
name: (S)-3-Methyl-2-oxopentanoate:[dihydrolipoyllysine-residue (2-methylpropanoyl)transferase] lipoyllysine 2-oxidoreductase (decarboxylating, acceptor-2-methylpropanoylating) EC:1.2.4.4
type: Reaction
fast: false
is described by: ECO:0000000
reactant: MODEL1310110061#
product: MODEL1310110061#
reversible: false
kinetic law: MODEL1310110061#
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110061#_8945b25b_5593_40ff_815e_b56b674090fe
is: Q9UJ37
boundary condition: true
is encoded by: hsa:10610
initial amount: NaN
type: Species
initial concentration: NaN
constant: false
name: ST6GALNAC2
has only substance units: false
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110061#_84e26807_8726_49ce_a446_a932f39fb3fc
boundary condition: true
has only substance units: false
name: PPA1
initial concentration: NaN
is: SBO:0000252
is: Q15181
constant: false
initial amount: NaN
type: Species
is encoded by: hsa:5464

metaM HC00361 c
is: SBO:0000247
type: Species
name: sedoheptulose 1,7-bisphosphate(4-)
initial concentration: 1.0
initial amount: NaN
notes: FORMULA: C7H12O13P2 CHARGE: -4 INCHI: InChI=1S/C7H16O13P2/c8-3(1-19-21(13,14)15)5(10)7(12)6(11)4(9)2-20-22(16,17)18/h3,5-8,10-12H,1-2H2,(H2,13,14,15)(H2,16,17,18)/p-4/t3-,5-,6-,7-/m1/s1 EHMN_ABBREVIATION: C00447
has only substance units: false
is: CHEBI:58335
constant: false
boundary condition: false

metaR 3MOBte
product: MODEL1310110061#
kinetic law: MODEL1310110061#
type: Reaction
reactant: MODEL1310110061#
is: SBO:0000185
name: Transport of 3-methyl-2-oxobutanoate
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
reversible: true
fast: false

metaM udp n
initial concentration: 1.0
boundary condition: false
is: CHEBI:58223
is: HMDB00295
name: UDP(3-)
initial amount: NaN
is: SBO:0000247
constant: false
notes: FORMULA: C9H11N2O12P2 CHARGE: -3 INCHI: InChI=1S/C9H14N2O12P2/c12-5-1-2-11(9(15)10-5)8-7(14)6(13)4(22-8)3-21-25(19,20)23-24(16,17)18/h1-2,4,6-8,13-14H,3H2,(H,19,20)(H,10,12,15)(H2,16,17,18)/p-3/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00025 EHMN_ABBREVIATION: C00015
type: Species
has only substance units: false

metaR FAOXC101m
kinetic law: MODEL1310110061#
product: MODEL1310110061#
reactant: MODEL1310110061#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: isomerization(C10:1)m
type: Reaction

metaR MI14PP
type: Reaction
is: SBO:0000176
is described by: ECO:0000269
modifier: MODEL1310110061#
is version of: http://identifiers.org/ec-code/3.1.3.57
reactant: MODEL1310110061#
kinetic law: MODEL1310110061#
product: MODEL1310110061#
name: inositol-1,4-bisphosphate 1-phosphatase
notes: GENE_ASSOCIATION: (3628.1) SUBSYSTEM: Inositol phosphate metabolism EC Number: 3.1.3.61 Confidence Level: 4 AUTHORS: PMID:2906139,PMID:8390685 NOTES:NCD
fast: false
reversible: false

metaR SRTNt6 2 r
is: SBO:0000185
reactant: MODEL1310110061#
modifier: MODEL1310110061#
reversible: true
kinetic law: MODEL1310110061#
fast: false
product: MODEL1310110061#
name: Seratonin reversible transport in via sodium symport/potassium antiport (1:2)
type: Reaction
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (6532.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12719981 NOTES:SAB

metaR FAS100COA
modifier: MODEL1310110061#
is version of: http://identifiers.org/ec-code/2.3.1.85
type: Reaction
fast: false
is described by: ECO:0000269
reversible: false
name: fatty acyl-CoA synthase (n-C10:0CoA)
reactant: MODEL1310110061#
notes: GENE_ASSOCIATION: (2194.1) SUBSYSTEM: Fatty acid synthesis EC Number: 2.3.1.86 Confidence Level: 4 AUTHORS: PMID:11756679,PMID:15507492,PMID:2669958 NOTES:NCD
product: MODEL1310110061#
is: SBO:0000176
kinetic law: MODEL1310110061#

metaR r1561
fast: false
type: Reaction
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
kinetic law: MODEL1310110061#
is: SBO:0000185
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is described by: ECO:0000000
reactant: MODEL1310110061#
product: MODEL1310110061#

http://identifiers.org/biomodels.db/MODEL1310110061#_db98620e_ca04_45a4_b0b3_fca500a56f56
has only substance units: false
boundary condition: true
is: C9JT23
is: SBO:0000252
initial amount: NaN
name: NDUFA11
type: Species
constant: false
is encoded by: hsa:126328
initial concentration: NaN

metaR MI145PP
is: SBO:0000176
type: Reaction
is version of: http://identifiers.org/ec-code/3.1.3.36
reversible: false
is version of: http://identifiers.org/ec-code/3.1.3.86
fast: false
name: inositol-1,4,5-trisphosphate 5-phosphatase
is version of: http://identifiers.org/ec-code/3.1.3.56
reactant: MODEL1310110061#
notes: GENE_ASSOCIATION: (3635.1) or (8867.2) or (3636.1) or (27124.2) or (8867.1) or (27124.1) or (3633.1) or (56623.1) or (3632.1) SUBSYSTEM: Inositol phosphate metabolism EC Number: 3.1.3.56 Confidence Level: 4 AUTHORS: PMID:10593988,PMID:10764818,PMID:15261714,PMID:2906139,PMID:7721860,PMID:8006039,PMID:8013665,PMID:8530088,PMID:8769125,PMID:9428629,PMID:9824312 NOTES:NCD
is described by: ECO:0000269
kinetic law: MODEL1310110061#
modifier: MODEL1310110061#
product: MODEL1310110061#

metaM lanost r
is: SBO:0000247
is: HMDB01251
notes: FORMULA: C30H50O CHARGE: 0 INCHI: InChI=1S/C30H50O/c1-20(2)10-9-11-21(3)22-14-18-30(8)24-12-13-25-27(4,5)26(31)16-17-28(25,6)23(24)15-19-29(22,30)7/h10,21-22,25-26,31H,9,11-19H2,1-8H3/t21-,22-,25+,26+,28-,29-,30+/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00833 EHMN_ABBREVIATION: C01724
has only substance units: false
type: Species
is: CHEBI:16521
constant: false
name: lanosterol
initial concentration: 1.0
boundary condition: false
initial amount: NaN

metaR r2514
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:17466261 NOTES:
reactant: MODEL1310110061#
is described by: ECO:0000000
fast: false
product: MODEL1310110061#
reversible: true
type: Reaction
name: Utilized transport
kinetic law: MODEL1310110061#

metaM HC02206 c
is: CHEBI:57399
constant: false
notes: FORMULA: C20H31O4 CHARGE: -1 INCHI: InChI=1S/C20H32O4/c1-2-3-6-9-17(21)14-12-16-13-15-19(22)18(16)10-7-4-5-8-11-20(23)24/h12-14,17-18,21H,2-11,15H2,1H3,(H,23,24)/p-1/b14-12+/t17-,18+/m0/s1 EHMN_ABBREVIATION: C04686
type: Species
is: SBO:0000247
boundary condition: false
initial concentration: 1.0
initial amount: NaN
name: prostaglandin C1(1-)
has only substance units: false

metaM fad c
boundary condition: false
type: Species
is: SBO:0000247
is: HMDB01248
initial concentration: 1.0
is: CHEBI:16238
notes: FORMULA: C27H31N9O15P2 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00026 EHMN_ABBREVIATION: C00016
has only substance units: false
constant: false
name: Flavin adenine dinucleotide oxidized
initial amount: NaN
is: C00016

metaM man c
type: Species
initial amount: NaN
has only substance units: false
initial concentration: 1.0
is: SBO:0000247
is: CHEBI:16024
is: C00159
is: HMDB00169
name: D-Mannose
notes: FORMULA: C6H12O6 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00154 EHMN_ABBREVIATION: C00159
constant: false
boundary condition: false

metaR EX acald LPAREN e RPAREN
kinetic law: MODEL1310110061#
reactant: MODEL1310110061#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Acetaldehyde exchange
type: Reaction

metaR r2347
product: MODEL1310110061#
is: SBO:0000185
reactant: MODEL1310110061#
kinetic law: MODEL1310110061#
fast: false
is described by: ECO:0000000
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
name: Organic anion transporter 5 Utilized transport
reversible: true

metaM 2dodtricoa m
has only substance units: false
is: SBO:0000247
initial concentration: 1.0
is: C05280
type: Species
constant: false
boundary condition: false
name: 2,6,9-dodecatrienoylcoa
is: HMDB03952
notes: FORMULA: C33H48N7O17P3S CHARGE: -4
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110061#_90042d7d_f654_4d05_b28f_007b7946829c
type: Species
is: P07195
is encoded by: hsa:3945
initial amount: NaN
boundary condition: true
is: SBO:0000252
initial concentration: NaN
constant: false
has only substance units: false
name: LDHB

metaR KCCt
is described by: ECO:0000269
fast: false
notes: GENE_ASSOCIATION: (10723.1) or (57468.1) or (9990.1) or (6560.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10187864,PMID:10347194,PMID:10600773,PMID:121106695,PMID:12657561,PMID:12739168,PMID:8663127 NOTES:NCD
type: Reaction
reactant: MODEL1310110061#
name: K+-Cl- cotransport
reversible: true
modifier: MODEL1310110061#
product: MODEL1310110061#
is: SBO:0000185
kinetic law: MODEL1310110061#

metaR r2116
kinetic law: MODEL1310110061#
fast: false
reversible: true
is: SBO:0000185
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
product: MODEL1310110061#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
type: Reaction
modifier: MODEL1310110061#
reactant: MODEL1310110061#

http://identifiers.org/biomodels.db/MODEL1310110061#_9b5363c4_242f_4bbf_8ff8_3f3693a64515
boundary condition: true
has only substance units: false
initial concentration: NaN
constant: false
type: Species
name: _AI469183_1_x
is encoded by: hsa:AI469183
initial amount: NaN
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110061#_70047698_ca2b_4664_9ca6_a7ab06b879b8
initial amount: NaN
is: P43166
has only substance units: false
is encoded by: hsa:766
name: CA7
boundary condition: true
type: Species
constant: false
is: SBO:0000252
initial concentration: NaN

metaR sink 5hpet LPAREN c RPAREN
kinetic law: MODEL1310110061#
reactant: MODEL1310110061#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: sink reaction for 5(S)-HPETE(1-)
type: Reaction

metaR SUCCtp
is described by: ECO:0000000
fast: false
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 0 AUTHORS: NOTES:unknown mechanism NJ
name: succinate transporter, peroxisome
product: MODEL1310110061#
reactant: MODEL1310110061#
type: Reaction
kinetic law: MODEL1310110061#
reversible: true

metaR BHBt
is described by: ECO:0000000
reactant: MODEL1310110061#
kinetic law: MODEL1310110061#
reversible: true
type: Reaction
fast: false
is: SBO:0000185
product: MODEL1310110061#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:1408469,PMID:16380372 NOTES:IT, TDV
name: (R)-3-Hydroxybutanoate transport via H+ symport

metaR AMETtd
fast: false
type: Reaction
name: diffusion of S-Adenosyl-L-methionine
reactant: MODEL1310110061#
is described by: ECO:0000134
reversible: true
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: NOTES:
product: MODEL1310110061#
kinetic law: MODEL1310110061#

metaR FAOXC143C123m
kinetic law: MODEL1310110061#
product: MODEL1310110061#
reactant: MODEL1310110061#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C14:3-->C12:3)m
type: Reaction

metaR EX thr L LPAREN e RPAREN
kinetic law: MODEL1310110061#
reactant: MODEL1310110061#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: L-Threonine exchange
type: Reaction

metaR D 3AIBt
name: D-3-amino-isobutyrate transport
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:
type: Reaction
product: MODEL1310110061#
is: SBO:0000185
reactant: MODEL1310110061#
reversible: false
kinetic law: MODEL1310110061#
is described by: ECO:0000000
fast: false

metaR NAt
reversible: true
product: MODEL1310110061#
notes: GENE_ASSOCIATION: (6526.1) or (6523.1) or (6528.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10893432,PMID:11024018,PMID:11034615,PMID:12679487,PMID:12748858,PMID:1372904,PMID:15546855,PMID:2490366,PMID:7537337,PMID:7789985,PMID:8063771,PMID:8559252,PMID:8806637,PMID:9341168 NOTES:
name: sodium transport (uniport)
kinetic law: MODEL1310110061#
type: Reaction
modifier: MODEL1310110061#
fast: false
is described by: ECO:0000269
is: SBO:0000185
reactant: MODEL1310110061#

metaR EX udp LPAREN e RPAREN
kinetic law: MODEL1310110061#
reactant: MODEL1310110061#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: UDP exchange
type: Reaction

metaR EX 10fthf6glu LPAREN e RPAREN
kinetic law: MODEL1310110061#
reactant: MODEL1310110061#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 10-formyltetrahydrofolate-[Glu](6) exchange
type: Reaction

metaR TMDPP
reversible: true
type: Reaction
modifier: MODEL1310110061#
is: SBO:0000176
fast: false
notes: GENE_ASSOCIATION: (1890.1) SUBSYSTEM: Pyrimidine catabolism EC Number: 2.4.2.4 Confidence Level: 4 AUTHORS: PMID:7028324,PMID:718961,PMID:9693094 NOTES:
reactant: MODEL1310110061#
product: MODEL1310110061#
is described by: ECO:0000269
name: thymidine phosphorylase
is version of: http://identifiers.org/ec-code/2.4.2.4
kinetic law: MODEL1310110061#

metaM 2obut c
initial concentration: 1.0
type: Species
is: CHEBI:16763
is: SBO:0000247
is: HMDB00005
constant: false
initial amount: NaN
is: C00109
name: 2-Oxobutanoate
boundary condition: false
notes: FORMULA: C4H5O3 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00108 EHMN_ABBREVIATION: C00109
has only substance units: false

metaR r1560
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is described by: ECO:0000000
is: SBO:0000185
reactant: MODEL1310110061#
product: MODEL1310110061#
type: Reaction
kinetic law: MODEL1310110061#
fast: false
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110061#_c9149c90_455b_48e5_b563_927be1695ac8
constant: false
initial concentration: NaN
boundary condition: true
is: Q96P26
type: Species
initial amount: NaN
has only substance units: false
is encoded by: hsa:93034
name: NT5C1B
is: SBO:0000252

metaM mi3p D c
name: 1D-myo-inositol 3-phosphate(2-)
initial amount: NaN
is: SBO:0000247
is: CHEBI:58401
boundary condition: false
has only substance units: false
type: Species
notes: FORMULA: C6H11O9P CHARGE: -2 INCHI: InChI=1S/C6H13O9P/c7-1-2(8)4(10)6(5(11)3(1)9)15-16(12,13)14/h1-11H,(H2,12,13,14)/p-2/t1-,2-,3+,4-,5-,6-/m0/s1
initial concentration: 1.0
constant: false
is: HMDB06814

metaM dtmp c
initial concentration: 1.0
type: Species
has only substance units: false
is: C00364
constant: false
name: dTMP
is: HMDB01227
initial amount: NaN
boundary condition: false
is: CHEBI:26999
is: SBO:0000247
notes: FORMULA: C10H13N2O8P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00308 EHMN_ABBREVIATION: C00364

http://identifiers.org/biomodels.db/MODEL1310110061#_61ffcd1d_1a2c_4416_b6f3_f44e8dbc75fd
has only substance units: false
name: ITPKB
is: SBO:0000252
boundary condition: true
is encoded by: hsa:3707
initial concentration: NaN
initial amount: NaN
is: P27987
constant: false
type: Species

metaR r2346
reactant: MODEL1310110061#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
is: SBO:0000185
type: Reaction
reversible: true
fast: false
product: MODEL1310110061#
name: Organic anion transporter 5 Utilized transport
kinetic law: MODEL1310110061#

http://identifiers.org/biomodels.db/MODEL1310110061#_01a6f0a7_a700_4355_ac09_0c6ffad586c1
constant: false
name: HADH
has only substance units: false
type: Species
is: Q16836
initial amount: NaN
boundary condition: true
is encoded by: hsa:3033
initial concentration: NaN
is: SBO:0000252

metaM meoh e
notes: FORMULA: CH4O1 CHARGE: 0 INCHI: InChI=1S/CH4O/c1-2/h2H,1H3 HEPATONET_1.0_ABBREVIATION: HC00130 EHMN_ABBREVIATION: C00132
initial amount: NaN
constant: false
initial concentration: 1.0
boundary condition: false
is: SBO:0000247
type: Species
is: CHEBI:17790
name: methanol
has only substance units: false
is: HMDB01875

metaR r0055
kinetic law: MODEL1310110061#
is version of: http://identifiers.org/ec-code/2.4.2.8
is: SBO:0000176
modifier: MODEL1310110061#
name: 2-Oxopropanal:NADP+ oxidoreductase Pyruvate metabolism EC:1.2.1.49
notes: GENE_ASSOCIATION: (353.1) or (3251.1) SUBSYSTEM: Pyruvate metabolism EC Number: 1.2.1.49 Confidence Level: 0 AUTHORS: PMID:20958,PMID:4383524,PMID:4391087,PMID:6014,PMID:7107625,PMID:7107626,PMID:7144586,PMID:7763257,PMID:7993370 NOTES:IT added 2 protons (are there really 2 protons produced?)
reversible: true
reactant: MODEL1310110061#
product: MODEL1310110061#
is described by: ECO:0000000
type: Reaction
fast: false
is version of: http://identifiers.org/ec-code/2.4.2.7

metaR GluForTx
reactant: MODEL1310110061#
notes: GENE_ASSOCIATION: (10841.1) or (10841.2) SUBSYSTEM: Histidine metabolism EC Number: 2.1.2.5 Confidence Level: 4 AUTHORS: PMID:12815595 NOTES:SAB
is described by: ECO:0000269
reversible: false
modifier: MODEL1310110061#
is: SBO:0000176
fast: false
product: MODEL1310110061#
kinetic law: MODEL1310110061#
name: Glutamate formimidoyltransferase
is version of: http://identifiers.org/ec-code/2.1.2.5
type: Reaction

metaR EX prostgd2 LPAREN e RPAREN
kinetic law: MODEL1310110061#
reactant: MODEL1310110061#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Prostaglandin D2 exchange
type: Reaction

metaR ALAtN1
notes: GENE_ASSOCIATION: (92745.1) or (10991.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10823827,PMID:12845534 NOTES:SAB based om PMID 10823827
reversible: true
is described by: ECO:0000269
name: Alanine transport (Na, H coupled)
is: SBO:0000185
modifier: MODEL1310110061#
reactant: MODEL1310110061#
type: Reaction
product: MODEL1310110061#
fast: false
kinetic law: MODEL1310110061#

http://identifiers.org/biomodels.db/MODEL1310110061#_f98c38a8_5e7e_4dc2_8735_f70d3fd69025
is: SBO:0000252
initial concentration: NaN
is: Q8IXK2
constant: false
boundary condition: true
is encoded by: hsa:79695
initial amount: NaN
type: Species
name: GALNT12
has only substance units: false

metaR r2117
is described by: ECO:0000000
product: MODEL1310110061#
fast: false
type: Reaction
reactant: MODEL1310110061#
is: SBO:0000185
kinetic law: MODEL1310110061#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
modifier: MODEL1310110061#
reversible: true

metaR TRDR
reactant: MODEL1310110061#
product: MODEL1310110061#
kinetic law: MODEL1310110061#
type: Reaction
reversible: false
is described by: ECO:0000269
name: thioredoxin reductase (NADPH)
is version of: http://identifiers.org/ec-code/1.8.1.9
modifier: MODEL1310110061#
fast: false
notes: GENE_ASSOCIATION: (7296.3) or (7296.1) or (7296.4) or (7296.2) SUBSYSTEM: Nucleotide interconversion EC Number: 1.8.1.9 Confidence Level: 4 AUTHORS: PMID:8577704,PMID:8999974 NOTES:
is: SBO:0000176

metaR LDH D
modifier: MODEL1310110061#
kinetic law: MODEL1310110061#
reactant: MODEL1310110061#
type: Reaction
is: SBO:0000176
reversible: true
product: MODEL1310110061#
name: D-lactate dehydrogenase
notes: GENE_ASSOCIATION: (197257.1) or (197257.2) SUBSYSTEM: Pyruvate metabolism EC Number: 1.1.1.28 Confidence Level: 2 AUTHORS: PMID:11955284,PMID:12127981 NOTES:See also LDL_L. D-lactate metabolism measured in rat mitochondria; probably depend on D-LDH activity in matrix plus transport activity across mitochondrial membrane; putative human D-LDH cloned ; D-lactate formed in nanomolar concentrations via the methylglyoxal pathway; D- -hydroxy acid dehydrogenase (EC 1.1.99.6)
fast: false
is version of: http://identifiers.org/ec-code/1.1.2.4
is described by: ECO:0000304

metaM 5fthf m
initial amount: NaN
is: SBO:0000247
name: 5-formyltetrahydrofolate(2-)
has only substance units: false
type: Species
is: CHEBI:57457
constant: false
is: HMDB01562
notes: FORMULA: C20H21N7O7 CHARGE: -2 INCHI: InChI=1S/C20H23N7O7/c21-20-25-16-15(18(32)26-20)27(9-28)12(8-23-16)7-22-11-3-1-10(2-4-11)17(31)24-13(19(33)34)5-6-14(29)30/h1-4,9,12-13,22H,5-8H2,(H,24,31)(H,29,30)(H,33,34)(H4,21,23,25,26,32)/p-2/t12-,13-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01125 EHMN_ABBREVIATION: C03479
boundary condition: false
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110061#_d8324a6b_cf55_4994_9a1a_75dc89a6524c
is encoded by: hsa:50700
has only substance units: false
initial amount: NaN
is: SBO:0000252
initial concentration: NaN
type: Species
boundary condition: true
is: Q9NYR8
name: RDH8
constant: false

metaR GLCMter
name: glucose transport via membrane vesicle
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11882499 NOTES:NCD
is described by: ECO:0000000
reversible: false
type: Reaction
reactant: MODEL1310110061#
product: MODEL1310110061#
kinetic law: MODEL1310110061#
fast: false

metaM clpnd e
notes: FORMULA: C22H33O2 CHARGE: -1 INCHI: InChI=1S/C22H34O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22(23)24/h3-4,6-7,9-10,12-13,15-16H,2,5,8,11,14,17-21H2,1H3,(H,23,24)/b4-3-,7-6-,10-9-,13-12-,16-15-
initial amount: NaN
initial concentration: 1.0
has only substance units: false
is: CHEBI:53488
is: SBO:0000247
name: clupanodonic acid
is: HMDB06528
constant: false
type: Species
boundary condition: false

metaR EX lcts LPAREN e RPAREN
kinetic law: MODEL1310110061#
reactant: MODEL1310110061#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Lactose exchange
type: Reaction

metaR MCLACCYSR
kinetic law: MODEL1310110061#
reversible: false
is: SBO:0000176
reactant: MODEL1310110061#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Methionine and cysteine metabolism EC Number: Confidence Level: 2 AUTHORS: PMID:6945862 NOTES:MM
name: 3-mercaptolactate:cysteine reductase
fast: false
type: Reaction
product: MODEL1310110061#

metaR EX ac LPAREN e RPAREN
kinetic law: MODEL1310110061#
reactant: MODEL1310110061#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Acetate exchange
type: Reaction

metaM 4hbzcoa m
name: 4-hydroxybenoyl-CoA
is: SBO:0000247
notes: FORMULA: C28H36N7O18P3S CHARGE: -4 INCHI: InChI=1/C28H40N7O18P3S/c1-28(2,22(39)25(40)31-8-7-18(37)30-9-10-57-27(41)15-3-5-16(36)6-4-15)12-50-56(47,48)53-55(45,46)49-11-17-21(52-54(42,43)44)20(38)26(51-17)35-14-34-19-23(29)32-13-33-24(19)35/h3-6,13-14,17,20-22,26,36,38-39H,7-12H2,1-2H3,(H,30,37)(H,31,40)(H,45,46)(H,47,48)(H2,29,32,33)(H2,42,43,44)/t17-,20?,21-,22+,26-/m1/s1
boundary condition: false
is: HMDB06467
type: Species
constant: false
initial amount: NaN
initial concentration: 1.0
has only substance units: false

metaM HC02217 e
is: CHEBI:27647
initial concentration: 1.0
type: Species
initial amount: NaN
is: SBO:0000247
boundary condition: false
constant: false
notes: FORMULA: C20H31O6 CHARGE: -1 INCHI: InChI=1S/C20H32O6/c1-2-3-6-9-15(24-23)12-13-17-16(18-14-19(17)26-25-18)10-7-4-5-8-11-20(21)22/h4,7,12-13,15-19,23H,2-3,5-6,8-11,14H2,1H3,(H,21,22)/b7-4-,13-12+/t15-,16+,17+,18-,19+/m0/s1 EHMN_ABBREVIATION: C05956
has only substance units: false
name: prostaglandin-g2

metaM clpn hs c
is: CHEBI:28494
initial concentration: 1.0
initial amount: NaN
type: Species
constant: false
is: SBO:0000247
has only substance units: false
name: cardiolipin
notes: FORMULA: C9H16O9P2FULLRCO2FULLR2CO2FULLRCO2FULLR2CO2 CHARGE: -2
boundary condition: false

metaM ala L m
type: Species
initial concentration: 1.0
name: L-alanine
constant: false
is: SBO:0000247
has only substance units: false
boundary condition: false
is: CHEBI:16977
is: HMDB00161
initial amount: NaN
notes: FORMULA: C3H7NO2 CHARGE: 0 INCHI: InChI=1S/C3H7NO2/c1-2(4)3(5)6/h2H,4H2,1H3,(H,5,6)/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00048

http://identifiers.org/biomodels.db/MODEL1310110061#_761ecd35_55d9_413a_83ac_c7387c5a6cbd
initial concentration: NaN
name: DLST
is: P36957
is: SBO:0000252
boundary condition: true
is encoded by: hsa:1743
initial amount: NaN
has only substance units: false
type: Species
constant: false

metaR r1563
type: Reaction
product: MODEL1310110061#
is: SBO:0000185
kinetic law: MODEL1310110061#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is described by: ECO:0000000
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reactant: MODEL1310110061#
fast: false

metaM dheas e
is: CHEBI:57905
has only substance units: false
initial concentration: 1.0
is: HMDB01032
constant: false
name: 3beta-hydroxyandrost-5-en-17-one 3-sulfate(1-)
boundary condition: false
initial amount: NaN
type: Species
notes: FORMULA: C19H27O5S CHARGE: -1 INCHI: InChI=1S/C19H28O5S/c1-18-9-7-13(24-25(21,22)23)11-12(18)3-4-14-15-5-6-17(20)19(15,2)10-8-16(14)18/h3,13-16H,4-11H2,1-2H3,(H,21,22,23)/p-1/t13-,14-,15-,16-,18-,19-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01314 EHMN_ABBREVIATION: C04555
is: SBO:0000247

metaR r2118
is: SBO:0000185
modifier: MODEL1310110061#
kinetic law: MODEL1310110061#
product: MODEL1310110061#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
type: Reaction
reactant: MODEL1310110061#
fast: false
reversible: true

metaR COQ6m
name: Ubiquinone biosynthesis monooxgenase COQ6
is described by: ECO:0000269
is: SBO:0000176
type: Reaction
reversible: false
fast: false
kinetic law: MODEL1310110061#
modifier: MODEL1310110061#
product: MODEL1310110061#
reactant: MODEL1310110061#
notes: GENE_ASSOCIATION: (51004.1) or (51004.2) SUBSYSTEM: Ubiquinone synthesis EC Number: Confidence Level: 4 AUTHORS: PMID:11051212,PMID:1965190,PMID:7380842 NOTES:_1.13.12.- IT

http://identifiers.org/biomodels.db/MODEL1310110061#_fb9b07ba_6918_44a7_901e_58a70ea542d7
initial amount: NaN
boundary condition: true
name: NADSYN1
is: SBO:0000252
constant: false
initial concentration: NaN
has only substance units: false
type: Species
is encoded by: hsa:55191
is: Q6IA69

metaR CHLPCTD
modifier: MODEL1310110061#
product: MODEL1310110061#
type: Reaction
name: choline phosphate cytididyltransferase
fast: false
is: SBO:0000176
notes: GENE_ASSOCIATION: (5130.1) or (9468.1) SUBSYSTEM: Glycerophospholipid metabolism EC Number: 2.7.7.15 Confidence Level: 4 AUTHORS: NOTES:NCD
reactant: MODEL1310110061#
is version of: http://identifiers.org/ec-code/2.7.7.15
is described by: ECO:0000269
kinetic law: MODEL1310110061#
reversible: false

metaM dlnlcgcoa r
is: SBO:0000247
constant: false
has only substance units: false
name: dihomo-gamma-linolenyl coenzyme A
initial amount: NaN
is: C03595
notes: FORMULA: C41H64N7O17P3S CHARGE: -4 INCHI: InChI=1S/C41H68N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-32(50)69-25-24-43-31(49)22-23-44-39(53)36(52)41(2,3)27-62-68(59,60)65-67(57,58)61-26-30-35(64-66(54,55)56)34(51)40(63-30)48-29-47-33-37(42)45-28-46-38(33)48/h8-9,11-12,14-15,28-30,34-36,40,51-52H,4-7,10,13,16-27H2,1-3H3,(H,43,49)(H,44,53)(H,57,58)(H,59,60)(H2,42,45,46)(H2,54,55,56)/b9-8-,12-11-,15-14-/t30-,34-,35-,36+,40-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC02102
is: CHEBI:27979
boundary condition: false
initial concentration: 1.0
type: Species

http://identifiers.org/biomodels.db/MODEL1310110061#_f79f2d3f_ab8d_4a1d_98b6_55265ae32da3
type: Species
is: SBO:0000252
initial concentration: NaN
is: Q9BZM2
name: PLA2G2F
has only substance units: false
is encoded by: hsa:64600
boundary condition: true
initial amount: NaN
constant: false

metaM man e
name: D-Mannose
initial amount: NaN
is: SBO:0000247
type: Species
initial concentration: 1.0
is: CHEBI:16024
is: C00159
has only substance units: false
is: HMDB00169
constant: false
notes: FORMULA: C6H12O6 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00154 EHMN_ABBREVIATION: C00159
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110061#_a3f946ea_e2b3_4225_bba0_7a0f35db6f1b
type: Species
initial concentration: NaN
boundary condition: true
is: SBO:0000252
is encoded by: hsa:6716
is: P31213
name: SRD5A2
constant: false
has only substance units: false
initial amount: NaN

metaM 3dpdhb me m
initial concentration: 1.0
initial amount: NaN
is: SBO:0000247
notes: FORMULA: C58H87O4 CHARGE: -1 INCHI: InChI=1S/C58H88O4/c1-44(2)22-13-23-45(3)24-14-25-46(4)26-15-27-47(5)28-16-29-48(6)30-17-31-49(7)32-18-33-50(8)34-19-35-51(9)36-20-37-52(10)38-21-39-53(11)40-41-54-42-55(58(60)61)43-56(62-12)57(54)59/h22,24,26,28,30,32,34,36,38,40,42-43,59H,13-21,23,25,27,29,31,33,35,37,39,41H2,1-12H3,(H,60,61)/b45-24+,46-26+,47-28+,48-30+,49-32+,50-34+,51-36+,52-38+,53-40+
is: CHEBI:50776
constant: false
boundary condition: false
has only substance units: false
type: Species
name: 3-Decaprenyl-4-hydroxy-5-methoxybenzoate

http://identifiers.org/biomodels.db/MODEL1310110061#_602d60dc_c632_4095_ba55_25723f33a9ab
name: AKR1D1
initial amount: NaN
is: SBO:0000252
is encoded by: hsa:6718
constant: false
boundary condition: true
initial concentration: NaN
type: Species
has only substance units: false
is: P51857

metaM 7thf e
boundary condition: false
initial amount: NaN
is: SBO:0000247
type: Species
notes: FORMULA: C49H57N13O24 CHARGE: -8
name: heptaglutamyl folate (THF)
constant: false
initial concentration: 1.0
has only substance units: false
is: HMDB06559

metaR ALADGLNexR
product: MODEL1310110061#
notes: GENE_ASSOCIATION: (56301.1) and (6520.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10734121,PMID:10863037,PMID:14770310 NOTES:
name: L-alanine/glutamine reversible exchange
fast: false
is: SBO:0000185
kinetic law: MODEL1310110061#
modifier: MODEL1310110061#
reversible: true
is described by: ECO:0000304
reactant: MODEL1310110061#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110061#_67970782_8a36_480f_ad10_7a62a4d0deb4
initial concentration: NaN
constant: false
is encoded by: hsa:AI972237
name: _AI972237_1_c
boundary condition: true
has only substance units: false
type: Species
is: SBO:0000252
initial amount: NaN

metaR EX dgmp LPAREN e RPAREN
kinetic law: MODEL1310110061#
reactant: MODEL1310110061#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of dGMP(2-)
type: Reaction

metaR ORNtiDF
reactant: MODEL1310110061#
is: SBO:0000185
notes: GENE_ASSOCIATION: (6542.1) or (6541.1) or (84889.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:11591158,PMID:11891586,PMID:12049641,PMID:1348489,PMID:14770310,PMID:7534987,PMID:8954799 NOTES:SAB
kinetic law: MODEL1310110061#
name: ornithine transport via diffusion (extracellular to cytosol)
modifier: MODEL1310110061#
reversible: false
type: Reaction
is described by: ECO:0000269
fast: false
product: MODEL1310110061#

http://identifiers.org/biomodels.db/MODEL1310110061#_921426b7_dfe6_4dd3_ac40_eaa5297a8600
name: NOS1
is encoded by: hsa:4842
is: SBO:0000252
type: Species
initial amount: NaN
is: B4DG68
has only substance units: false
constant: false
initial concentration: NaN
boundary condition: true

metaM dpcoa m
notes: FORMULA: C21H33N7O13P2S CHARGE: -2 INCHI: InChI=1S/C21H35N7O13P2S/c1-21(2,16(32)19(33)24-4-3-12(29)23-5-6-44)8-39-43(36,37)41-42(34,35)38-7-11-14(30)15(31)20(40-11)28-10-27-13-17(22)25-9-26-18(13)28/h9-11,14-16,20,30-32,44H,3-8H2,1-2H3,(H,23,29)(H,24,33)(H,34,35)(H,36,37)(H2,22,25,26)/p-2/t11-,14-,15-,16+,20-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00575 EHMN_ABBREVIATION: C00882
initial amount: NaN
is: HMDB01373
boundary condition: false
initial concentration: 1.0
constant: false
name: 3'-dephospho-CoA(2-)
has only substance units: false
is: SBO:0000247
type: Species
is: CHEBI:57328

metaM lnlccoa c
is: http://identifiers.org/pubchem.compound/5462164
boundary condition: false
has only substance units: false
initial concentration: 1.0
constant: false
initial amount: NaN
is: HMDB01064
type: Species
name: linoleic coenzyme A
is: SBO:0000247
notes: FORMULA: C39H62N7O17P3S CHARGE: -4 INCHI: InChI=1/C39H66N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-30(48)67-23-22-41-29(47)20-21-42-37(51)34(50)39(2,3)25-60-66(57,58)63-65(55,56)59-24-28-33(62-64(52,53)54)32(49)38(61-28)46-27-45-31-35(40)43-26-44-36(31)46/h8-9,11-12,26-28,32-34,38,49-50H,4-7,10,13-25H2,1-3H3,(H,41,47)(H,42,51)(H,55,56)(H,57,58)(H2,40,43,44)(H2,52,53,54)/b9-8+,12-11+

http://identifiers.org/biomodels.db/MODEL1310110061#_68cef706_45ac_428a_b3b8_5d99539d0d5e
constant: false
boundary condition: true
initial concentration: NaN
is encoded by: hsa:55568
type: Species
is: SBO:0000252
initial amount: NaN
has only substance units: false
is: Q86SR1
name: GALNT10

http://identifiers.org/biomodels.db/MODEL1310110061#_a550b29f_5f6b_425c_a40d_cb72fd3387cf
constant: false
boundary condition: true
is encoded by: hsa:7355
initial amount: NaN
is: P78381
initial concentration: NaN
is: SBO:0000252
type: Species
name: SLC35A2
has only substance units: false

metaR r2119
is described by: ECO:0000000
type: Reaction
reactant: MODEL1310110061#
is: SBO:0000185
modifier: MODEL1310110061#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
reversible: true
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
fast: false
kinetic law: MODEL1310110061#
product: MODEL1310110061#

metaR r1562
is: SBO:0000185
reactant: MODEL1310110061#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
type: Reaction
product: MODEL1310110061#
fast: false
kinetic law: MODEL1310110061#
is described by: ECO:0000000
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:

metaM dtmp e
is: SBO:0000247
initial concentration: 1.0
is: CHEBI:26999
name: dTMP(2-)
is: HMDB01227
boundary condition: false
initial amount: NaN
type: Species
notes: FORMULA: C10H13N2O8P CHARGE: -2 INCHI: InChI=1S/C10H15N2O8P/c1-5-3-12(10(15)11-9(5)14)8-2-6(13)7(20-8)4-19-21(16,17)18/h3,6-8,13H,2,4H2,1H3,(H,11,14,15)(H2,16,17,18)/p-2/t6-,7+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00308 EHMN_ABBREVIATION: C00364
constant: false
has only substance units: false

metaR EX dttp LPAREN e RPAREN
kinetic law: MODEL1310110061#
reactant: MODEL1310110061#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of dTTP(4-)
type: Reaction

metaR EX ps hs LPAREN e RPAREN
kinetic law: MODEL1310110061#
reactant: MODEL1310110061#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: phosphatidylserine (homo sapiens) exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110061#_76f036d3_84cb_4958_b49e_ee556bf9fa80
name: NDUFB3
boundary condition: true
is encoded by: hsa:4709
type: Species
is: Q6IB80
has only substance units: false
initial amount: NaN
initial concentration: NaN
constant: false
is: SBO:0000252

metaR RE1254C
name: RE1254
is: SBO:0000176
product: MODEL1310110061#
fast: false
reversible: true
reactant: MODEL1310110061#
notes: GENE_ASSOCIATION: SUBSYSTEM: Lysine metabolism EC Number: 1.14.17.1 Confidence Level: 0 AUTHORS: PMID:3443096,PMID:7759508,PMID:9763470 NOTES:
kinetic law: MODEL1310110061#
type: Reaction
is described by: ECO:0000000

metaM meoh c
is: HMDB01875
notes: FORMULA: CH4O1 CHARGE: 0 INCHI: InChI=1S/CH4O/c1-2/h2H,1H3 HEPATONET_1.0_ABBREVIATION: HC00130 EHMN_ABBREVIATION: C00132
initial concentration: 1.0
boundary condition: false
initial amount: NaN
constant: false
type: Species
is: SBO:0000247
name: methanol
has only substance units: false
is: CHEBI:17790

metaM HC02213 c
type: Species
is: SBO:0000247
is: CHEBI:28031
constant: false
notes: FORMULA: C20H29O5 CHARGE: -1 INCHI: InChI=1S/C20H30O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h3-4,6-7,12-13,15-17,19,21,23H,2,5,8-11,14H2,1H3,(H,24,25)/b6-3-,7-4-,13-12+/t15-,16+,17+,19+/m0/s1 EHMN_ABBREVIATION: C06439
boundary condition: false
name: prostaglandin-e3
initial concentration: 1.0
initial amount: NaN
has only substance units: false

metaR EX coa LPAREN e RPAREN
kinetic law: MODEL1310110061#
reactant: MODEL1310110061#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for coa
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110061#_bedf51e1_a14c_4040_9790_6c2aa47dc2f7
is: SBO:0000252
boundary condition: true
name: PANK2
has only substance units: false
constant: false
is: Q6P1K9
type: Species
is encoded by: hsa:80025
initial concentration: NaN
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110061#_654b052c_3cc1_4999_884f_68088ad529bd
is encoded by: hsa:8529
is: P78329
constant: false
type: Species
initial amount: NaN
initial concentration: NaN
boundary condition: true
is: SBO:0000252
name: CYP4F2
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110061#_70fb8e3f_7851_46d3_9de2_760cdc1ce811
has only substance units: false
constant: false
initial amount: NaN
type: Species
name: ACAD8
is encoded by: hsa:27034
initial concentration: NaN
boundary condition: true
is: SBO:0000252
is: Q6ZWP6

metaM hista c
has only substance units: false
constant: false
initial concentration: 1.0
boundary condition: false
initial amount: NaN
name: histamium
notes: FORMULA: C5H10N3 CHARGE: 1 INCHI: InChI=1S/C5H9N3/c6-2-1-5-3-7-4-8-5/h3-4H,1-2,6H2,(H,7,8)/p+1 HEPATONET_1.0_ABBREVIATION: HC00323 EHMN_ABBREVIATION: C00388
is: HMDB00870
type: Species
is: CHEBI:58432
is: SBO:0000247

metaM inost e
notes: FORMULA: C6H12O6 CHARGE: 0 INCHI: InChI=1S/C6H12O6/c7-1-2(8)4(10)6(12)5(11)3(1)9/h1-12H/t1-,2-,3-,4+,5-,6- HEPATONET_1.0_ABBREVIATION: HC00135 EHMN_ABBREVIATION: C00137
is: CHEBI:17268
name: myo-inositol
initial concentration: 1.0
is: SBO:0000247
initial amount: NaN
has only substance units: false
constant: false
boundary condition: false
type: Species
is: HMDB00211

metaM acetone m
notes: FORMULA: C3H6O CHARGE: 0 INCHI: InChI=1S/C3H6O/c1-3(2)4/h1-2H3 HEPATONET_1.0_ABBREVIATION: HC00193 EHMN_ABBREVIATION: C00207
has only substance units: false
initial concentration: 1.0
name: acetone
is: SBO:0000247
is: HMDB01659
is: CHEBI:15347
constant: false
type: Species
initial amount: NaN
boundary condition: false

metaR UREAt
product: MODEL1310110061#
reactant: MODEL1310110061#
type: Reaction
reversible: true
kinetic law: MODEL1310110061#
fast: false
is: SBO:0000185
name: Urea transport via facilitate diffusion
notes: GENE_ASSOCIATION: (6523.1) or (6563.1) or (6528.1) or (8170.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10893432,PMID:11024018,PMID:11034615,PMID:12679487,PMID:12748858,PMID:12856182,PMID:2490366,PMID:8063771,PMID:8559252,PMID:8806637,PMID:9341168 NOTES:JLR
is described by: ECO:0000269
modifier: MODEL1310110061#

http://identifiers.org/biomodels.db/MODEL1310110061#_9dd4e8f1_8cb4_4d12_b010_9a4d480267f6
initial concentration: NaN
is: Q9NY65
is encoded by: hsa:1962
name: EHHADH
initial amount: NaN
type: Species
boundary condition: true
constant: false
has only substance units: false
is: SBO:0000252

metaM clpnd c
has only substance units: false
type: Species
notes: FORMULA: C22H33O2 CHARGE: -1 INCHI: InChI=1S/C22H34O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22(23)24/h3-4,6-7,9-10,12-13,15-16H,2,5,8,11,14,17-21H2,1H3,(H,23,24)/b4-3-,7-6-,10-9-,13-12-,16-15-
initial amount: NaN
is: CHEBI:53488
is: SBO:0000247
name: clupanodonic acid
boundary condition: false
is: HMDB06528
constant: false
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110061#_6baa611a_6661_419c_80aa_1a6d2204ec90
is: SBO:0000252
constant: false
name: GPX1
initial amount: NaN
boundary condition: true
type: Species
is: P07203
initial concentration: NaN
is encoded by: hsa:2876
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110061#_d360fe97_6da6_4976_b35b_a33543ae6822
is: E9PCP2
initial amount: NaN
name: CPT1B
is encoded by: hsa:1375
type: Species
constant: false
is: SBO:0000252
boundary condition: true
has only substance units: false
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110061#_0d982c62_5c6e_4656_ae0c_bddaff13529c
constant: false
is: Q8WWX8
initial concentration: NaN
is encoded by: hsa:115584
type: Species
name: SLC5A11
has only substance units: false
is: SBO:0000252
boundary condition: true
initial amount: NaN

metaR DALAt2r
type: Reaction
fast: false
name: D-alanine transport via proton symport
kinetic law: MODEL1310110061#
product: MODEL1310110061#
modifier: MODEL1310110061#
reversible: true
notes: GENE_ASSOCIATION: (206358.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11390972,PMID:11959859 NOTES:JLR
reactant: MODEL1310110061#
is described by: ECO:0000304
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110061#_9c710703_e58b_4e36_8c6b_4c6536f16b13
name: GAPDH
type: Species
is encoded by: hsa:2597
is: E7EUT4
constant: false
is: SBO:0000252
boundary condition: true
initial concentration: NaN
has only substance units: false
initial amount: NaN

metaR r1298
fast: false
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
name: Vesicular transport
kinetic law: MODEL1310110061#
is: SBO:0000185
is described by: ECO:0000000
reactant: MODEL1310110061#
reversible: false
product: MODEL1310110061#

metaM c226coa m
is: C16169
is: http://identifiers.org/pubchem.compound/47205479
has only substance units: false
boundary condition: false
notes: FORMULA: C43H62N7O17P3S CHARGE: -4 INCHI: InChI=1/C43H66N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-34(52)71-27-26-45-33(51)24-25-46-41(55)38(54)43(2,3)29-64-70(61,62)67-69(59,60)63-28-32-37(66-68(56,57)58)36(53)42(65-32)50-31-49-35-39(44)47-30-48-40(35)50/h5-6,8-9,11-12,14-15,17-18,20-21,30-32,36-38,42,53-54H,4,7,10,13,16,19,22-29H2,1-3H3,(H,45,51)(H,46,55)(H,59,60)(H,61,62)(H2,44,47,48)(H2,56,57,58)/b6-5-,9-8-,12-11-,15-14-,18-17-,21-20-/t32-,36-,37-,38?,42-/m1/s1
name: cervonyl coenzyme A
is: SBO:0000247
initial concentration: 1.0
constant: false
initial amount: NaN
type: Species

http://identifiers.org/biomodels.db/MODEL1310110061#_08f900d9_7b8d_443a_8d1a_464f0ae73d32
is: SBO:0000252
is encoded by: hsa:93034
name: NT5C1B
initial amount: NaN
is: Q96P26
constant: false
has only substance units: false
initial concentration: NaN
boundary condition: true
type: Species

metaR r2518
kinetic law: MODEL1310110061#
reactant: MODEL1310110061#
reversible: true
name: ATP-binding Cassette (ABC) TCDB:3.A.1.203.1
is described by: ECO:0000000
product: MODEL1310110061#
type: Reaction
fast: false
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 0 AUTHORS: PMID:17173541 NOTES:

metaR ARACHDt2
is: SBO:0000185
product: MODEL1310110061#
reversible: true
fast: false
kinetic law: MODEL1310110061#
is described by: ECO:0000000
name: fatty acid transport via diffusion
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11788354,PMID:12864740 NOTES:NJ
reactant: MODEL1310110061#

metaM dadp m
initial concentration: 1.0
type: Species
constant: false
is: CHEBI:57667
is: HMDB01508
name: dADP(3-)
boundary condition: false
initial amount: NaN
has only substance units: false
notes: FORMULA: C10H12N5O9P2 CHARGE: -3 INCHI: InChI=1S/C10H15N5O9P2/c11-9-8-10(13-3-12-9)15(4-14-8)7-1-5(16)6(23-7)2-22-26(20,21)24-25(17,18)19/h3-7,16H,1-2H2,(H,20,21)(H2,11,12,13)(H2,17,18,19)/p-3/t5-,6+,7+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00192 EHMN_ABBREVIATION: C00206
is: SBO:0000247

metaM HC02217 c
type: Species
is: CHEBI:27647
constant: false
initial amount: NaN
boundary condition: false
notes: FORMULA: C20H31O6 CHARGE: -1 INCHI: InChI=1S/C20H32O6/c1-2-3-6-9-15(24-23)12-13-17-16(18-14-19(17)26-25-18)10-7-4-5-8-11-20(21)22/h4,7,12-13,15-19,23H,2-3,5-6,8-11,14H2,1H3,(H,21,22)/b7-4-,13-12+/t15-,16+,17+,18-,19+/m0/s1 EHMN_ABBREVIATION: C05956
name: prostaglandin-g2
initial concentration: 1.0
has only substance units: false
is: SBO:0000247

metaM dheas c
initial concentration: 1.0
is: CHEBI:57905
constant: false
name: 3beta-hydroxyandrost-5-en-17-one 3-sulfate(1-)
has only substance units: false
is: SBO:0000247
type: Species
notes: FORMULA: C19H27O5S CHARGE: -1 INCHI: InChI=1S/C19H28O5S/c1-18-9-7-13(24-25(21,22)23)11-12(18)3-4-14-15-5-6-17(20)19(15,2)10-8-16(14)18/h3,13-16H,4-11H2,1-2H3,(H,21,22,23)/p-1/t13-,14-,15-,16-,18-,19-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01314 EHMN_ABBREVIATION: C04555
boundary condition: false
is: HMDB01032
initial amount: NaN

metaR r1565
type: Reaction
is: SBO:0000185
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
fast: false
kinetic law: MODEL1310110061#
is described by: ECO:0000000
reactant: MODEL1310110061#
product: MODEL1310110061#

http://identifiers.org/biomodels.db/MODEL1310110061#_a90f848b_65ce_4419_a04a_63d2a5c91223
type: Species
boundary condition: true
initial amount: NaN
is: SBO:0000252
has only substance units: false
constant: false
is encoded by: hsa:55350
name: VNN3
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110061#_420e6ab7_a80f_4fb0_a837_36623dfe3bdc
is: SBO:0000252
boundary condition: true
initial concentration: NaN
is: O75251
name: NDUFS7
is encoded by: hsa:374291
constant: false
initial amount: NaN
type: Species
has only substance units: false

metaM 6thf e
notes: FORMULA: C44H51N12O21 CHARGE: -7 INCHI: InChI=1/C44H54N12O21/c45-21(36(66)67)5-10-26(57)43(15-30(61)62,27(58)11-6-22(46)37(68)69)44(28(59)12-7-23(47)38(70)71,41(76)77-31(63)14-9-25(49)40(74)75)56(29(60)13-8-24(48)39(72)73)35(65)18-1-3-19(4-2-18)51-16-20-17-52-33-32(53-20)34(64)55-42(50)54-33/h1-4,17,21-25,51H,5-16,45-49H2,(H,61,62)(H,66,67)(H,68,69)(H,70,71)(H,72,73)(H,74,75)(H3,50,52,54,55,64)/p-1/t21u,22u,23u,24u,25u,43u,44-/m1/s1
has only substance units: false
boundary condition: false
constant: false
is: SBO:0000247
name: hexaglutamyl folate (THF)
is: http://identifiers.org/pubchem.compound/169691
initial concentration: 1.0
type: Species
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110061#_f7286be4_9f18_454f_87b8_91f21db1e5dd
is: SBO:0000252
initial amount: NaN
has only substance units: false
is encoded by: hsa:AA526438
name: _AA526438_1_c
boundary condition: true
type: Species
constant: false
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110061#_2b05736b_c70e_4452_9f87_f453c99d4789
has only substance units: false
is encoded by: hsa:197257
is: SBO:0000252
type: Species
initial amount: NaN
name: LDHD
is: Q86WU2
boundary condition: true
initial concentration: NaN
constant: false

ORG:
  orgname: University of Iceland
n:
  given: Ines
  family: Thiele

metaM pro D c
constant: false
type: Species
is: SBO:0000247
is: CHEBI:16313
name: D-proline
is: HMDB03411
boundary condition: false
initial concentration: 1.0
notes: FORMULA: C5H9NO2 CHARGE: 0 INCHI: InChI=1S/C5H9NO2/c7-5(8)4-2-1-3-6-4/h4,6H,1-3H2,(H,7,8)/t4-/m1/s1
initial amount: NaN
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110061#_4b3344e2_ae2e_40b7_b60f_568ec0b627d7
name: GALNT7
constant: false
boundary condition: true
initial concentration: NaN
is encoded by: hsa:51809
initial amount: NaN
type: Species
is: SBO:0000252
has only substance units: false
is: Q86SF2

metaR r0051
kinetic law: MODEL1310110061#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.1.3.5
fast: false
reactant: MODEL1310110061#
modifier: MODEL1310110061#
notes: GENE_ASSOCIATION: (AI769281.1) or (30833.1) or (93034.1) or (22978.1) or (51251.1) or (4907.1) or (56953.1) or (57786.1) or (57665.1) SUBSYSTEM: Purine catabolism EC Number: 2.4.2.7 Confidence Level: 0 AUTHORS: PMID:6778226,PMID:692402 NOTES:
is described by: ECO:0000000
product: MODEL1310110061#
name: AMP:pyrophosphate phosphoribosyltransferase Purine metabolism EC:2.4.2.7
reversible: true
type: Reaction

metaR GLYtm
kinetic law: MODEL1310110061#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:7388024 NOTES:TDV Biochim Biophys Acta. 1980 Jun 6;598(3):588-94
is: SBO:0000185
reversible: true
product: MODEL1310110061#
name: glycine passive transport to mitochondria
is described by: ECO:0000000
fast: false
reactant: MODEL1310110061#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110061#_3b431486_b1f7_4fa1_b59e_0486dab715cb
initial concentration: NaN
is: SBO:0000252
is: E5KSL6
name: DGUOK
initial amount: NaN
is encoded by: hsa:1716
has only substance units: false
constant: false
type: Species
boundary condition: true

metaM leuktrB4 c
initial concentration: 1.0
name: leukotriene B4(1-)
notes: FORMULA: C20H31O4 CHARGE: -1 INCHI: InChI=1S/C20H32O4/c1-2-3-4-5-6-9-13-18(21)14-10-7-8-11-15-19(22)16-12-17-20(23)24/h6-11,14-15,18-19,21-22H,2-5,12-13,16-17H2,1H3,(H,23,24)/p-1/b8-7+,9-6-,14-10+,15-11-/t18-,19-/m1/s1 EHMN_ABBREVIATION: C02165
is: CHEBI:57461
is: SBO:0000247
type: Species
boundary condition: false
is: HMDB01085
has only substance units: false
constant: false
initial amount: NaN

metaR RE1522M
is version of: http://identifiers.org/ec-code/2.3.1.16
modifier: MODEL1310110061#
fast: false
notes: GENE_ASSOCIATION: (1892.1) or (3030.1) or (1962.1) or (3032.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.17 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:7775433,PMID:7923814,PMID:9568246,PMID:9920399 NOTES:
is: SBO:0000176
product: MODEL1310110061#
kinetic law: MODEL1310110061#
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/4.2.1.17
name: RE1522
reversible: true
is version of: http://identifiers.org/ec-code/1.1.1.35
reactant: MODEL1310110061#
type: Reaction

metaR r2519
is: SBO:0000185
product: MODEL1310110061#
type: Reaction
name: Utilized transport
kinetic law: MODEL1310110061#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:16611737,PMID:18307097 NOTES:
reactant: MODEL1310110061#
reversible: true
is described by: ECO:0000000
fast: false

http://identifiers.org/biomodels.db/MODEL1310110061#_2834332e_3ca2_465c_8fe2_921cee7405fc
is encoded by: hsa:1036
type: Species
constant: false
name: CDO1
initial amount: NaN
initial concentration: NaN
is: SBO:0000252
boundary condition: true
has only substance units: false
is: Q16878

metaR r1564
fast: false
reactant: MODEL1310110061#
product: MODEL1310110061#
type: Reaction
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
kinetic law: MODEL1310110061#
is: SBO:0000185
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110061#_31467091_81cb_47a6_93c1_bca537e6f626
initial concentration: NaN
boundary condition: true
has only substance units: false
type: Species
is encoded by: hsa:AI656480
constant: false
initial amount: NaN
is: SBO:0000252
name: _AI656480_1_m

metaM tdcoa c
is: C02593
name: Tetradecanoyl-CoA (n-C14:0CoA)
initial concentration: 1.0
is: HMDB01521
notes: FORMULA: C35H58N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00971 EHMN_ABBREVIATION: C02593
is: SBO:0000247
boundary condition: false
has only substance units: false
constant: false
type: Species
initial amount: NaN
is: CHEBI:57385

metaM hista e
has only substance units: false
name: histamium
notes: FORMULA: C5H10N3 CHARGE: 1 INCHI: InChI=1S/C5H9N3/c6-2-1-5-3-7-4-8-5/h3-4H,1-2,6H2,(H,7,8)/p+1 HEPATONET_1.0_ABBREVIATION: HC00323 EHMN_ABBREVIATION: C00388
initial concentration: 1.0
is: CHEBI:58432
initial amount: NaN
type: Species
is: HMDB00870
is: SBO:0000247
constant: false
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110061#_185510d6_16ed_4c1c_bacb_a2bbda10cdf3
type: Species
boundary condition: true
initial concentration: NaN
is: SBO:0000252
constant: false
has only substance units: false
is encoded by: hsa:M68895
initial amount: NaN
name: _M68895_1_c

metaM Ssq23epx r
notes: FORMULA: C30H50O CHARGE: 0 INCHI: InChI=1S/C30H50O/c1-24(2)14-11-17-27(5)20-12-18-25(3)15-9-10-16-26(4)19-13-21-28(6)22-23-29-30(7,8)31-29/h14-16,20-21,29H,9-13,17-19,22-23H2,1-8H3/b25-15+,26-16+,27-20+,28-21+/t29-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00645 EHMN_ABBREVIATION: C01054
has only substance units: false
is: HMDB01188
is: SBO:0000247
initial concentration: 1.0
is: CHEBI:15441
boundary condition: false
name: (S)-2,3-epoxysqualene
constant: false
type: Species
initial amount: NaN

metaR ILEt5m
type: Reaction
product: MODEL1310110061#
name: Isoleucine mitochondrial transport
reversible: true
fast: false
is: SBO:0000185
kinetic law: MODEL1310110061#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:11004451 NOTES:MM
reactant: MODEL1310110061#
is described by: ECO:0000000

metaM udp l
type: Species
boundary condition: false
name: UDP(3-)
notes: FORMULA: C9H11N2O12P2 CHARGE: -3 INCHI: InChI=1S/C9H14N2O12P2/c12-5-1-2-11(9(15)10-5)8-7(14)6(13)4(22-8)3-21-25(19,20)23-24(16,17)18/h1-2,4,6-8,13-14H,3H2,(H,19,20)(H,10,12,15)(H2,16,17,18)/p-3/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00025 EHMN_ABBREVIATION: C00015
is: HMDB00295
is: SBO:0000247
has only substance units: false
initial concentration: 1.0
is: CHEBI:58223
initial amount: NaN
constant: false

metaR CEPTC
kinetic law: MODEL1310110061#
reactant: MODEL1310110061#
reversible: false
is version of: http://identifiers.org/ec-code/2.7.8.2
is described by: ECO:0000269
product: MODEL1310110061#
fast: false
type: Reaction
notes: GENE_ASSOCIATION: (10390.1) or (56994.1) SUBSYSTEM: Glycerophospholipid metabolism EC Number: Confidence Level: 4 AUTHORS: NOTES:NJ
name: choline phosphotransferase
modifier: MODEL1310110061#
is: SBO:0000176

metaR EX glcur LPAREN e RPAREN
kinetic law: MODEL1310110061#
reactant: MODEL1310110061#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: D-glucuronate exchange
type: Reaction

metaR EX vacc LPAREN e RPAREN
kinetic law: MODEL1310110061#
reactant: MODEL1310110061#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: vaccenic acid exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110061#_f4779c24_c925_4245_a1bc_04877c44f052
name: _AI024818_1_c
initial amount: NaN
initial concentration: NaN
constant: false
type: Species
is: SBO:0000252
boundary condition: true
has only substance units: false
is encoded by: hsa:AI024818

metaR EX chtn LPAREN e RPAREN
kinetic law: MODEL1310110061#
reactant: MODEL1310110061#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: chitin exchange
type: Reaction

metaR RE3001M
type: Reaction
is: SBO:0000176
modifier: MODEL1310110061#
is version of: http://identifiers.org/ec-code/1.3.1.34
kinetic law: MODEL1310110061#
notes: GENE_ASSOCIATION: (1666.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.1.34 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:7775433 NOTES:
product: MODEL1310110061#
is described by: ECO:0000000
name: RE3001
reversible: true
fast: false
reactant: MODEL1310110061#

http://identifiers.org/biomodels.db/MODEL1310110061#_daa5f680_9abd_4141_9972_dfc6ac3affb5
is: P19801
boundary condition: true
initial concentration: NaN
is: SBO:0000252
name: ABP1
constant: false
is encoded by: hsa:26
has only substance units: false
initial amount: NaN
type: Species

http://identifiers.org/biomodels.db/MODEL1310110061#_8c303095_5512_40b8_90c0_22ce65194497
is: SBO:0000252
has only substance units: false
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:1892
constant: false
is: P30084
boundary condition: true
type: Species
name: ECHS1

metaR PE HStm
kinetic law: MODEL1310110061#
reversible: true
is: SBO:0000185
reactant: MODEL1310110061#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 1 AUTHORS: NOTES:
name: phosphatidylethanolamine scramblase
product: MODEL1310110061#
type: Reaction
fast: false
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110061#_abdb1a64_4cd3_42ff_989d_9cd7566d05c3
is encoded by: hsa:3631
boundary condition: true
type: Species
has only substance units: false
name: INPP4A
is: SBO:0000252
initial concentration: NaN
constant: false
initial amount: NaN

metaR EX btn LPAREN e RPAREN
kinetic law: MODEL1310110061#
reactant: MODEL1310110061#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Biotin exchange
type: Reaction

metaR PCm
product: MODEL1310110061#
name: pyruvate carboxylase
is version of: http://identifiers.org/ec-code/6.4.1.1
fast: false
reactant: MODEL1310110061#
is: SBO:0000176
type: Reaction
kinetic law: MODEL1310110061#
notes: GENE_ASSOCIATION: (5091.1) or (5091.2) SUBSYSTEM: Pyruvate metabolism EC Number: 6.4.1.1 Confidence Level: 4 AUTHORS: PMID:6548474 NOTES:TV Metabolism at a glance
is described by: ECO:0000269
modifier: MODEL1310110061#
reversible: false

metaR O2t
product: MODEL1310110061#
is described by: ECO:0000000
reversible: true
reactant: MODEL1310110061#
kinetic law: MODEL1310110061#
name: o2 transport (diffusion)
is: SBO:0000185
type: Reaction
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 1 AUTHORS: NOTES:tv renamed from O2TP to O2t to avoid confusion with transport reaction from cytosol to peroxisome NCD

metaR RE1533M
notes: GENE_ASSOCIATION: (10449.1) or (3032.1) or (3030.1) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.16 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:7923814,PMID:9568246,PMID:9920399 NOTES:
is version of: http://identifiers.org/ec-code/2.3.1.16
reactant: MODEL1310110061#
is: SBO:0000176
fast: false
product: MODEL1310110061#
reversible: true
is described by: ECO:0000000
modifier: MODEL1310110061#
kinetic law: MODEL1310110061#
name: RE1533
is version of: http://identifiers.org/ec-code/4.2.1.17
type: Reaction

metaR EX CE2838 LPAREN e RPAREN
kinetic law: MODEL1310110061#
reactant: MODEL1310110061#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: maltononaose exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110061#_e429e0f6_c5b0_4956_a4df_5c84210a51dd
is: SBO:0000252
type: Species
initial concentration: NaN
constant: false
name: _D87002_1_m
boundary condition: true
has only substance units: false
initial amount: NaN
is encoded by: hsa:D87002

metaR r2516
reactant: MODEL1310110061#
fast: false
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 0 AUTHORS: PMID:12739169,PMID:18305372 NOTES:
reversible: true
product: MODEL1310110061#
type: Reaction
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
is: SBO:0000185
kinetic law: MODEL1310110061#

metaR r1567
fast: false
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
kinetic law: MODEL1310110061#
is described by: ECO:0000000
reactant: MODEL1310110061#
type: Reaction
is: SBO:0000185
product: MODEL1310110061#

http://identifiers.org/biomodels.db/MODEL1310110061#_3f803d98_75ba_450a_8693_1fbdb9c4f2c2
type: Species
constant: false
has only substance units: false
initial concentration: NaN
name: _NOS2A_1_c
is: SBO:0000252
is encoded by: hsa:NOS2A
initial amount: NaN
boundary condition: true

metaR r0321
notes: GENE_ASSOCIATION: (AA664770.1) or (AI684467.1) or (8833.1) SUBSYSTEM: Cholesterol metabolism EC Number: 6.2.1.16 Confidence Level: 0 AUTHORS: PMID:4073493 NOTES:
kinetic law: MODEL1310110061#
is version of: http://identifiers.org/ec-code/6.3.5.2
product: MODEL1310110061#
modifier: MODEL1310110061#
name: Acetoacetate:CoA ligase (AMP-forming) Butanoate metabolism EC:6.2.1.16
type: Reaction
is described by: ECO:0000000
reactant: MODEL1310110061#
fast: false
is: SBO:0000176
reversible: false

metaM HC02206 e
boundary condition: false
initial amount: NaN
has only substance units: false
constant: false
is: CHEBI:57399
type: Species
name: prostaglandin C1(1-)
initial concentration: 1.0
is: SBO:0000247
notes: FORMULA: C20H31O4 CHARGE: -1 INCHI: InChI=1S/C20H32O4/c1-2-3-6-9-17(21)14-12-16-13-15-19(22)18(16)10-7-4-5-8-11-20(23)24/h12-14,17-18,21H,2-11,15H2,1H3,(H,23,24)/p-1/b14-12+/t17-,18+/m0/s1 EHMN_ABBREVIATION: C04686

http://identifiers.org/biomodels.db/MODEL1310110061#_7420e02f_05d6_4b91_9c0b_9540dc5a0429
initial concentration: NaN
is: SBO:0000252
type: Species
initial amount: NaN
is: P27144
boundary condition: true
name: AK4
constant: false
has only substance units: false
is encoded by: hsa:205

metaM fru c
notes: FORMULA: C6H12O6 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00097 EHMN_ABBREVIATION: C00095
is: C00095
constant: false
initial concentration: 1.0
is: HMDB00660
initial amount: NaN
is: CHEBI:15824
is: SBO:0000247
name: D-Fructose
boundary condition: false
type: Species
has only substance units: false

metaM dcacoa c
name: Decanoyl-CoA (n-C10:0CoA)
is: SBO:0000247
type: Species
constant: false
initial amount: NaN
initial concentration: 1.0
is: CHEBI:61430
boundary condition: false
is: C05274
is: HMDB06404
notes: FORMULA: C31H50N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC01413 EHMN_ABBREVIATION: C05274
has only substance units: false

metaM 3decdicoa m
boundary condition: false
has only substance units: false
constant: false
initial amount: NaN
is: SBO:0000247
name: 3,7-decadienoylcoa
initial concentration: 1.0
is: http://identifiers.org/pubchem.compound/16019966
type: Species
notes: FORMULA: C31H46N7O17P3S CHARGE: -4

metaM pro D e
type: Species
is: HMDB03411
is: CHEBI:16313
name: D-proline
boundary condition: false
initial amount: NaN
initial concentration: 1.0
notes: FORMULA: C5H9NO2 CHARGE: 0 INCHI: InChI=1S/C5H9NO2/c7-5(8)4-2-1-3-6-4/h4,6H,1-3H2,(H,7,8)/t4-/m1/s1
constant: false
is: SBO:0000247
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110061#_f6c45768_4e07_462c_9139_a6138594ef40
is encoded by: hsa:5723
constant: false
has only substance units: false
initial amount: NaN
type: Species
is: SBO:0000252
boundary condition: true
initial concentration: NaN
is: P78330
name: PSPH

http://identifiers.org/biomodels.db/MODEL1310110061#_ff5846c5_6ecb_4b82_8c58_16db2f7f6b6f
initial concentration: NaN
initial amount: NaN
boundary condition: true
is: SBO:0000252
is encoded by: hsa:AA502753
constant: false
name: _AA502753_1_m
has only substance units: false
type: Species

metaR FRDPtcr
reversible: true
is described by: ECO:0000134
product: MODEL1310110061#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: required for cholesterol synthesis in E.R. NOTES:required for cholesterol synthesis in E.R.
is: SBO:0000185
reactant: MODEL1310110061#
name: transport of Farnesyl diphosphate into the endoplasmic reticulum
kinetic law: MODEL1310110061#
fast: false
type: Reaction

metaR r1299
reversible: false
kinetic law: MODEL1310110061#
is described by: ECO:0000000
fast: false
reactant: MODEL1310110061#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
is: SBO:0000185
name: Vesicular transport
product: MODEL1310110061#
type: Reaction

metaM glyald m
is: CHEBI:17378
initial amount: NaN
notes: FORMULA: C3H6O3 CHARGE: 0 INCHI: InChI=1S/C3H6O3/c4-1-3(6)2-5/h1,3,5-6H,2H2/t3-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00436 EHMN_ABBREVIATION: C00577
boundary condition: false
has only substance units: false
constant: false
name: D-glyceraldehyde
type: Species
initial concentration: 1.0
is: HMDB01051
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110061#_810de7cf_eb5c_4d3e_87ea_6bf0730c9c3c
initial amount: NaN
is: SBO:0000252
has only substance units: false
is: Q53FV7
name: CPT1B
constant: false
type: Species
initial concentration: NaN
is encoded by: hsa:1375
boundary condition: true

metaM prostge2 c
is: CHEBI:606564
has only substance units: false
notes: FORMULA: C20H31O5 CHARGE: -1 INCHI: InChI=1S/C20H32O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h4,7,12-13,15-17,19,21,23H,2-3,5-6,8-11,14H2,1H3,(H,24,25)/p-1/b7-4-,13-12+/t15-,16+,17+,19+/m0/s1 EHMN_ABBREVIATION: C00584
is: SBO:0000247
boundary condition: false
is: HMDB01220
type: Species
initial concentration: 1.0
initial amount: NaN
name: prostaglandin E2(1-)
constant: false

metaR r1566
fast: false
reactant: MODEL1310110061#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
type: Reaction
product: MODEL1310110061#
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is: SBO:0000185
kinetic law: MODEL1310110061#
is described by: ECO:0000000

metaR r2517
is described by: ECO:0000000
is: SBO:0000185
reversible: true
product: MODEL1310110061#
type: Reaction
fast: false
kinetic law: MODEL1310110061#
name: ATP-binding Cassette (ABC) TCDB:3.A.1.203.1
reactant: MODEL1310110061#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 0 AUTHORS: PMID:17173541 NOTES:

metaM leuktrB4 e
initial concentration: 1.0
boundary condition: false
constant: false
has only substance units: false
initial amount: NaN
is: SBO:0000247
is: HMDB01085
is: CHEBI:57461
notes: FORMULA: C20H31O4 CHARGE: -1 INCHI: InChI=1S/C20H32O4/c1-2-3-4-5-6-9-13-18(21)14-10-7-8-11-15-19(22)16-12-17-20(23)24/h6-11,14-15,18-19,21-22H,2-5,12-13,16-17H2,1H3,(H,23,24)/p-1/b8-7+,9-6-,14-10+,15-11-/t18-,19-/m1/s1 EHMN_ABBREVIATION: C02165
type: Species
name: leukotriene B4(1-)

http://identifiers.org/biomodels.db/MODEL1310110061#_65837a5f_a97b_417d_98e1_fe31a52566ab
is: Q16222
initial concentration: NaN
name: UAP1
has only substance units: false
is encoded by: hsa:6675
boundary condition: true
constant: false
is: SBO:0000252
type: Species
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110061#_e0040da6_ae74_4b2a_95cc_fc0c38b89445
is encoded by: hsa:3295
constant: false
initial amount: NaN
is: SBO:0000252
initial concentration: NaN
name: HSD17B4
type: Species
has only substance units: false
boundary condition: true
is: E9PB82

metaR EX ala B LPAREN e RPAREN
kinetic law: MODEL1310110061#
reactant: MODEL1310110061#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: beta-Alanine exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110061#_ccfbcd10_b269_4abf_bb9e_f2f0ffbcf680
initial concentration: NaN
is encoded by: hsa:11001
is: O14975
initial amount: NaN
is: SBO:0000252
constant: false
has only substance units: false
name: SLC27A2
boundary condition: true
type: Species

metaR ADK1m
reactant: MODEL1310110061#
product: MODEL1310110061#
modifier: MODEL1310110061#
kinetic law: MODEL1310110061#
notes: GENE_ASSOCIATION: (205.3) or (205.1) or (204.1) or (204.3) or (204.2) or (205.2) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.3 Confidence Level: 4 AUTHORS: PMID:11485571,PMID:195572,PMID:8843353,PMID:9434148 NOTES:NCD
type: Reaction
reversible: true
is: SBO:0000176
is described by: ECO:0000269
fast: false
is version of: http://identifiers.org/ec-code/2.7.4.3
name: adenylate kinase, mitochondrial

http://identifiers.org/biomodels.db/MODEL1310110061#_a5f57e53_e4fb_4a61_bb44_6d1c358b7101
is: SBO:0000252
has only substance units: false
is encoded by: hsa:10166
boundary condition: true
is: Q9Y619
constant: false
initial amount: NaN
initial concentration: NaN
name: SLC25A15
type: Species

metaM glyb c
name: glycine betaine
boundary condition: false
is: SBO:0000247
is: CHEBI:17750
notes: FORMULA: C5H11NO2 CHARGE: 0 INCHI: InChI=1S/C5H11NO2/c1-6(2,3)4-5(7)8/h4H2,1-3H3 HEPATONET_1.0_ABBREVIATION: HC00515 EHMN_ABBREVIATION: C00719
constant: false
initial concentration: 1.0
initial amount: NaN
has only substance units: false
is: HMDB00043
type: Species

http://identifiers.org/biomodels.db/MODEL1310110061#_9c0ab68e_c7c1_4888_9b85_933f2f594f45
boundary condition: true
type: Species
name: FLAD1
is encoded by: hsa:80308
initial concentration: NaN
has only substance units: false
constant: false
is: SBO:0000252
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110061#_af919aa3_195b_44c7_a150_fa97fe5fb919
is: SBO:0000252
is: A0S0A7
name: NOS3
initial amount: NaN
boundary condition: true
has only substance units: false
type: Species
constant: false
initial concentration: NaN
is encoded by: hsa:4846

metaM L dpchrm c
name: L-dopachromate
is: HMDB01430
is: CHEBI:57509
type: Species
initial concentration: 1.0
is: SBO:0000247
notes: FORMULA: C9H6NO4 CHARGE: -1 INCHI: InChI=1S/C9H7NO4/c11-7-2-4-1-6(9(13)14)10-5(4)3-8(7)12/h2-3,6,10H,1H2,(H,13,14)/p-1/t6-/m0/s1 EHMN_ABBREVIATION: C01693
boundary condition: false
constant: false
initial amount: NaN
has only substance units: false

metaR GGLUCT
type: Reaction
name: gamma-glutamylcyclotransferase
notes: GENE_ASSOCIATION: (79017.1) SUBSYSTEM: Glutathione metabolism EC Number: 2.3.2.4 Confidence Level: 4 AUTHORS: PMID:2570694 NOTES:SAB
reactant: MODEL1310110061#
fast: false
is: SBO:0000185
product: MODEL1310110061#
reversible: false
is version of: http://identifiers.org/ec-code/2.3.2.4
kinetic law: MODEL1310110061#
is described by: ECO:0000269
modifier: MODEL1310110061#

metaR DURAD
notes: GENE_ASSOCIATION: (1806.1) SUBSYSTEM: Pyrimidine catabolism EC Number: 1.3.1.2 Confidence Level: 4 AUTHORS: PMID:1512248,PMID:8221682 NOTES:_01-26-05 IT based on Lu et al., JBC,1992,24,17102-17109
kinetic law: MODEL1310110061#
name: dihydrouracil dehydrogenase (NADP)
is version of: http://identifiers.org/ec-code/1.3.1.2
is: SBO:0000176
modifier: MODEL1310110061#
product: MODEL1310110061#
reversible: true
type: Reaction
fast: false
reactant: MODEL1310110061#
is described by: ECO:0000269

metaM nh4 m
initial concentration: 1.0
boundary condition: false
name: Ammonium
is: HMDB00051
is: CHEBI:28938
constant: false
is: SBO:0000247
type: Species
notes: FORMULA: H4N CHARGE: 1 HEPATONET_1.0_ABBREVIATION: HC00765 EHMN_ABBREVIATION: C01342
has only substance units: false
is: C01342
initial amount: NaN

metaR URCN
modifier: MODEL1310110061#
product: MODEL1310110061#
kinetic law: MODEL1310110061#
name: URCN
notes: GENE_ASSOCIATION: (131669.1) SUBSYSTEM: Histidine metabolism EC Number: Confidence Level: 4 AUTHORS: NOTES:
is version of: http://identifiers.org/ec-code/4.2.1.49
type: Reaction
is: SBO:0000176
is described by: ECO:0000269
fast: false
reversible: false
reactant: MODEL1310110061#

http://identifiers.org/biomodels.db/MODEL1310110061#_81dc4504_591e_4c0d_9678_342249e9d4af
boundary condition: true
name: SLC9A4
initial amount: NaN
type: Species
has only substance units: false
is: SBO:0000252
initial concentration: NaN
is encoded by: hsa:389015
constant: false
is: Q6AI14

http://identifiers.org/biomodels.db/MODEL1310110061#_dd5c5cfb_af3b_4c48_a1bc_eb7ba0609ac8
has only substance units: false
is: P46721
initial concentration: NaN
constant: false
name: SLCO1A2
type: Species
initial amount: NaN
boundary condition: true
is encoded by: hsa:6579
is: SBO:0000252

metaR r0734
reactant: MODEL1310110061#
reversible: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.17 Confidence Level: 0 AUTHORS: PMID:8012501,PMID:8188243 NOTES:
name: (S)-Hydroxyhexanoyl-CoA hydro-lyase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:4.2.1.17
is: SBO:0000176
fast: false
product: MODEL1310110061#
is described by: ECO:0000000
kinetic law: MODEL1310110061#
type: Reaction

metaM CE5132 c
boundary condition: false
initial concentration: 1.0
notes: FORMULA: C11H14O19P3R2 CHARGE: -5 EHMN_ABBREVIATION: CE5132
is: CHEBI:57923
is: SBO:0000247
name: 1-phosphatidyl-1D-myo-inositol 3,5-bisphosphate(5-)
type: Species
initial amount: NaN
has only substance units: false
constant: false

http://identifiers.org/biomodels.db/MODEL1310110061#_f5f47328_1aa2_4ae4_9e05_4e90f710b92a
initial concentration: NaN
is: P07954
name: FH
has only substance units: false
initial amount: NaN
is encoded by: hsa:2271
is: SBO:0000252
type: Species
boundary condition: true
constant: false

metaM dcsptn1crn m
notes: FORMULA: C29H47NO4 CHARGE: 0 INCHI: InChI=1/C29H47NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-24-29(33)34-27(25-28(31)32)26-30(2,3)4/h9-10,12-13,15-16,18-19,21-22,27H,5-8,11,14,17,20,23-26H2,1-4H3/b10-9+,13-12+,16-15+,19-18+,22-21+
has only substance units: false
constant: false
type: Species
initial amount: NaN
is: HMDB06321
initial concentration: 1.0
boundary condition: false
is: SBO:0000247
name: docosa-4,7,10,13,16-pentaenoyl carnitine

metaR H2Oter
is: SBO:0000185
reversible: true
name: H2O endoplasmic reticulum transport
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD
fast: false
product: MODEL1310110061#
reactant: MODEL1310110061#
kinetic law: MODEL1310110061#
type: Reaction
is described by: ECO:0000000

metaM dcyt e
is: CHEBI:15698
type: Species
initial amount: NaN
boundary condition: false
constant: false
is: C00881
notes: FORMULA: C9H13N3O4 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00574 EHMN_ABBREVIATION: C00881
has only substance units: false
initial concentration: 1.0
name: Deoxycytidine
is: SBO:0000247
is: HMDB00014

metaR r1106
product: MODEL1310110061#
reactant: MODEL1310110061#
is described by: ECO:0000000
fast: false
is: SBO:0000185
reversible: true
kinetic law: MODEL1310110061#
name: Postulated transport reaction
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:10049700,PMID:10574970,PMID:11389679,PMID:11557028,PMID:11564694,PMID:12824232,PMID:12930836,PMID:14574404,PMID:16288981,PMID:911815 NOTES:

metaR EX tetpent6 LPAREN e RPAREN
kinetic law: MODEL1310110061#
reactant: MODEL1310110061#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: tetracosapentaenoic acid, n-6 exchange
type: Reaction

metaR VLCSp
fast: false
product: MODEL1310110061#
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (11001.1) SUBSYSTEM: Bile acid synthesis EC Number: 6.2.1.7 Confidence Level: 4 AUTHORS: NOTES:from uniprot and lit - see human recon lit refs divalent cation requirement - unclear which one, reaction inhibited in the presence of EDTA (may just be MgATP or MgATP) - see Kelley and Vessey Biochimica et Biophysica Acta (1994) 1209: 51-55 temporarily will have H+ balance reaction NJ
is: SBO:0000176
modifier: MODEL1310110061#
name: Very-long-chain-fatty-acid-CoA ligase
reactant: MODEL1310110061#
reversible: false
type: Reaction
is version of: http://identifiers.org/ec-code/6.2.1.3
kinetic law: MODEL1310110061#

metaR B3GALTg
fast: false
is: SBO:0000176
name: Beta galactosyltransferase
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Blood group synthesis EC Number: 2.4.1.86 Confidence Level: 2 AUTHORS: NOTES:general reaction - no gene association get NJ
reactant: MODEL1310110061#
product: MODEL1310110061#
kinetic law: MODEL1310110061#
is described by: ECO:0000000
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110061#_93f4bcac_42be_42fc_856a_e9d44cc6d650
name: MAOA
initial concentration: NaN
constant: false
has only substance units: false
initial amount: NaN
is encoded by: hsa:4128
boundary condition: true
is: SBO:0000252
type: Species
is: Q53YE7

metaM nh4 n
initial amount: NaN
constant: false
is: SBO:0000247
type: Species
initial concentration: 1.0
is: HMDB00051
is: CHEBI:28938
has only substance units: false
boundary condition: false
name: ammonium
notes: FORMULA: H4N CHARGE: 1 INCHI: InChI=1S/H3N/h1H3/p+1 HEPATONET_1.0_ABBREVIATION: HC00765 EHMN_ABBREVIATION: C01342

metaM pheacgln e
initial amount: NaN
constant: false
is: HMDB06344
notes: FORMULA: C13H16N2O4 CHARGE: 0 INCHI: InChI=1S/C13H16N2O4/c14-11(16)7-6-10(13(18)19)15-12(17)8-9-4-2-1-3-5-9/h1-5,10H,6-8H2,(H2,14,16)(H,15,17)(H,18,19)/p-1/t10-/m0/s1
initial concentration: 1.0
has only substance units: false
is: SBO:0000247
type: Species
name: (2S)-4-carbamoyl-2-(2-phenylacetamido)butanoate
boundary condition: false
is: CHEBI:58310

metaR EX CE5788 LPAREN e RPAREN
kinetic law: MODEL1310110061#
reactant: MODEL1310110061#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: kinetensin 1-7 exchange
type: Reaction

metaR GARFT
modifier: MODEL1310110061#
notes: GENE_ASSOCIATION: (2618.1) or (2618.2) SUBSYSTEM: Purine synthesis EC Number: 2.1.2.2 Confidence Level: 4 AUTHORS: PMID:12450384,PMID:2183217,PMID:9328467,PMID:9473452 NOTES:
reactant: MODEL1310110061#
is: SBO:0000176
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/2.1.2.2
reversible: true
name: phosphoribosylglycinamide formyltransferase
type: Reaction
kinetic law: MODEL1310110061#
product: MODEL1310110061#
fast: false

metaM e4hglu m
is: SBO:0000247
constant: false
is: HMDB02273
is: CHEBI:6331
boundary condition: false
name: erythro-4-hydroxy-L-glutamate(1-)
notes: FORMULA: C5H8NO5 CHARGE: -1 INCHI: InChI=1S/C5H9NO5/c6-2(4(8)9)1-3(7)5(10)11/h2-3,7H,1,6H2,(H,8,9)(H,10,11)/p-1/t2-,3+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01663 EHMN_ABBREVIATION: C05947
has only substance units: false
initial concentration: 1.0
initial amount: NaN
type: Species

metaR r0735
is version of: http://identifiers.org/ec-code/1.2.1.3
notes: GENE_ASSOCIATION: (AA081045.1) or (AI620219.1) or (219.1) or (217.1) or (224.1) or (501.1) or (223.1) or (AU149534.1) or (T83654.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.1.38 Confidence Level: 0 AUTHORS: PMID:12654921 NOTES:
is: SBO:0000176
reversible: true
product: MODEL1310110061#
is described by: ECO:0000000
kinetic law: MODEL1310110061#
type: Reaction
modifier: MODEL1310110061#
reactant: MODEL1310110061#
fast: false
name: trans-Dec-2-enoyl-CoA reductase Fatty acid elongation in mitochondria EC:1.3.1.38

http://identifiers.org/biomodels.db/MODEL1310110061#_1656ab34_3a2e_487d_9399_1c86dfe1b1b5
boundary condition: true
initial amount: NaN
type: Species
is: SBO:0000252
name: _PRO1933_1_m
has only substance units: false
is encoded by: hsa:PRO1933
constant: false
initial concentration: NaN

metaM gluside hs g
has only substance units: false
initial amount: NaN
is: SBO:0000247
boundary condition: false
type: Species
notes: FORMULA: C24H46NO7FULLRCO CHARGE: 0 EHMN_ABBREVIATION: C01190
initial concentration: 1.0
is: CHEBI:18368
name: D-glucosyl-N-acylsphingosine
constant: false

metaM ppcoa m
initial amount: NaN
constant: false
boundary condition: false
is: CHEBI:57392
notes: FORMULA: C24H36N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00101 EHMN_ABBREVIATION: C00100
is: C00100
is: HMDB01275
is: SBO:0000247
has only substance units: false
initial concentration: 1.0
type: Species
name: Propanoyl-CoA

metaM ipdp x
is: SBO:0000247
boundary condition: false
name: isopentenyl diphosphate(3-)
type: Species
is: HMDB01347
notes: FORMULA: C5H9O7P2 CHARGE: -3 INCHI: InChI=1S/C5H12O7P2/c1-5(2)3-4-11-14(9,10)12-13(6,7)8/h1,3-4H2,2H3,(H,9,10)(H2,6,7,8)/p-3 HEPATONET_1.0_ABBREVIATION: HC00127 EHMN_ABBREVIATION: C00129
constant: false
initial amount: NaN
is: CHEBI:128769
has only substance units: false
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110061#_cc99effb_a55c_4604_a2eb_1061df695bf3
constant: false
has only substance units: false
is: O75438
type: Species
initial concentration: NaN
name: NDUFB1
is: SBO:0000252
initial amount: NaN
boundary condition: true
is encoded by: hsa:4707

metaR DTTPtn
name: dTTP diffusion in nucleus
type: Reaction
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: NOTES:IT
reactant: MODEL1310110061#
product: MODEL1310110061#
reversible: true
kinetic law: MODEL1310110061#
is described by: ECO:0000000
is: SBO:0000185

metaR METtec
reversible: true
modifier: MODEL1310110061#
fast: false
kinetic law: MODEL1310110061#
type: Reaction
product: MODEL1310110061#
name: L-methionine transport via diffusion (extracellular to cytosol)
reactant: MODEL1310110061#
notes: GENE_ASSOCIATION: (8501.1) or (124935.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12930836,PMID:14624363,PMID:15659399 NOTES:SAB
is: SBO:0000185
is described by: ECO:0000269

metaM octe5coa m
is: http://identifiers.org/pubchem.compound/16019966
notes: FORMULA: C29H44N7O17P3S CHARGE: -4
is: SBO:0000247
boundary condition: false
initial amount: NaN
initial concentration: 1.0
name: 5-octenoylcoa
has only substance units: false
constant: false
type: Species

metaR RE1520M
modifier: MODEL1310110061#
type: Reaction
reversible: true
is: SBO:0000176
notes: GENE_ASSOCIATION: (1892.1) or (3030.1) or (1962.1) or (3032.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.17 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:7923814,PMID:9568246,PMID:9920399 NOTES:
is version of: http://identifiers.org/ec-code/1.1.1.35
is version of: http://identifiers.org/ec-code/4.2.1.17
kinetic law: MODEL1310110061#
product: MODEL1310110061#
reactant: MODEL1310110061#
is described by: ECO:0000000
fast: false
is version of: http://identifiers.org/ec-code/2.3.1.16
name: RE1520

http://identifiers.org/biomodels.db/MODEL1310110061#_4b95cba8_96fa_42cf_a09e_292f76532118
is: Q9H903
initial concentration: NaN
constant: false
has only substance units: false
initial amount: NaN
is: SBO:0000252
is encoded by: hsa:441024
boundary condition: true
type: Species
name: MTHFD2L

metaR UGALGTg
fast: false
notes: GENE_ASSOCIATION: (3906.1) and (2683.1) or (8704.2) or (8704.1) SUBSYSTEM: Galactose metabolism EC Number: 2.4.1.22 Confidence Level: 4 AUTHORS: PMID:11419947 NOTES:NCD
is described by: ECO:0000134
kinetic law: MODEL1310110061#
type: Reaction
modifier: MODEL1310110061#
product: MODEL1310110061#
reversible: false
name: UDPgalactose:D-glucose 4-beta-D-galactosyltransferase, Golgi apparatus
is version of: http://identifiers.org/ec-code/2.4.1.22
is: SBO:0000176
reactant: MODEL1310110061#

http://identifiers.org/biomodels.db/MODEL1310110061#_2bf6a513_0df9_438b_97a0_a94296224b5c
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:29988
boundary condition: true
name: SLC2A8
is: SBO:0000252
is: Q9NY64
has only substance units: false
type: Species
constant: false

metaR EX 7thf LPAREN e RPAREN
kinetic law: MODEL1310110061#
reactant: MODEL1310110061#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: heptaglutamyl folate (THF) exchange
type: Reaction

metaR ACALDt
is: SBO:0000185
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:NCD
reactant: MODEL1310110061#
is described by: ECO:0000000
fast: false
kinetic law: MODEL1310110061#
reversible: true
name: acetaldehyde reversible transport
product: MODEL1310110061#

http://identifiers.org/biomodels.db/MODEL1310110061#_15f3bbf0_d2ab_4df6_9030_96e35e0db447
is: SBO:0000252
type: Species
has only substance units: false
name: HKDC1
initial concentration: NaN
boundary condition: true
constant: false
is encoded by: hsa:80201
initial amount: NaN
is: B3KT70

http://identifiers.org/biomodels.db/MODEL1310110061#_6d72135b_63e1_4a56_b1ac_222a6ab8eb03
has only substance units: false
name: _206_1_c
initial concentration: NaN
initial amount: NaN
constant: false
boundary condition: true
is: SBO:0000252
type: Species
is encoded by: hsa:206

metaR GGT5r
is described by: ECO:0000134
type: Reaction
is version of: http://identifiers.org/ec-code/2.3.2.2
modifier: MODEL1310110061#
reactant: MODEL1310110061#
is: SBO:0000176
name: Gamma-glutamyltransferase 5
reversible: true
kinetic law: MODEL1310110061#
fast: false
product: MODEL1310110061#
notes: GENE_ASSOCIATION: (2687.1) SUBSYSTEM: Eicosanoid metabolism EC Number: 2.3.2.2 Confidence Level: 4 AUTHORS: PMID:18357468,PMID:18357469,PMID:6120203 NOTES:Cleaves the gamma-glutamyl peptide bond of glutathione conjugates, but maybe not glutathione itself. Converts leukotriene C4 (LTC4) to leukotriene D4 (LTD4). NJ

metaM ethamp c
is: SBO:0000247
is: HMDB00224
notes: FORMULA: C2H7NO4P CHARGE: -1 INCHI: InChI=1S/C2H8NO4P/c3-1-2-7-8(4,5)6/h1-3H2,(H2,4,5,6)/p-1 HEPATONET_1.0_ABBREVIATION: HC00293 EHMN_ABBREVIATION: C00346
constant: false
type: Species
boundary condition: false
has only substance units: false
name: ethamp[c]
initial concentration: 1.0
is: CHEBI:58190
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110061#_2cb9abf1_a51b_4ebb_bede_77f4241eae57
is encoded by: hsa:AI378339
initial concentration: NaN
name: _AI378339_1_m
is: SBO:0000252
type: Species
has only substance units: false
constant: false
boundary condition: true
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110061#_0940521f_1765_4ec8_8ee0_d761de2c89c2
initial amount: NaN
initial concentration: NaN
has only substance units: false
boundary condition: true
is: SBO:0000252
constant: false
name: _AI091231_1_c
type: Species
is encoded by: hsa:AI091231

http://identifiers.org/biomodels.db/MODEL1310110061#_7c75d0a6_1467_4469_9cbb_05cb1e900e78
initial concentration: NaN
has only substance units: false
initial amount: NaN
type: Species
is encoded by: hsa:229
is: P05062
name: ALDOB
constant: false
boundary condition: true
is: SBO:0000252

metaM 4h2oglt m
is: CHEBI:17742
boundary condition: false
notes: FORMULA: C5H4O6 CHARGE: -2 INCHI: InChI=1S/C5H6O6/c6-2(4(8)9)1-3(7)5(10)11/h2,6H,1H2,(H,8,9)(H,10,11)/p-2
initial amount: NaN
is: HMDB02070
has only substance units: false
constant: false
initial concentration: 1.0
type: Species
name: 4-hydroxy-2-oxoglutarate(2-)
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110061#_59d66e35_4bec_4c4f_a09b_b97511c82fde
has only substance units: false
is encoded by: hsa:51268
name: PIPOX
is: Q9P0Z9
boundary condition: true
type: Species
constant: false
initial amount: NaN
is: SBO:0000252
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110061#_1ab4023f_3d91_4339_90d2_03cf001a9556
has only substance units: false
is encoded by: hsa:7372
initial concentration: NaN
type: Species
initial amount: NaN
is: SBO:0000252
is: A8K5J1
constant: false
boundary condition: true
name: UMPS

metaM bilglcur r
boundary condition: false
initial concentration: 1.0
is: CHEBI:57767
constant: false
type: Species
is: SBO:0000247
name: mono(glucosyluronic acid)bilirubin(2-)
notes: FORMULA: C39H44N4O12 CHARGE: 0 INCHI: InChI=1S/C39H44N4O12/c1-7-20-19(6)36(50)43-27(20)14-25-18(5)23(10-12-31(46)54-39-34(49)32(47)33(48)35(55-39)38(52)53)29(41-25)15-28-22(9-11-30(44)45)17(4)24(40-28)13-26-16(3)21(8-2)37(51)42-26/h7-8,13-14,32-35,39-41,47-49H,1-2,9-12,15H2,3-6H3,(H,42,51)(H,43,50)(H,44,45)(H,52,53)/p-2/b26-13+,27-14+/t32-,33-,34+,35-,39+/m0/s1 EHMN_ABBREVIATION: C03374
initial amount: NaN
has only substance units: false

metaR KAS8
is described by: ECO:0000269
kinetic law: MODEL1310110061#
reactant: MODEL1310110061#
product: MODEL1310110061#
type: Reaction
is version of: http://identifiers.org/ec-code/2.3.1.85
is: SBO:0000176
name: b-ketoacyl synthetase (palmitate, n-C16:0)
notes: GENE_ASSOCIATION: (2194.1) SUBSYSTEM: Fatty acid synthesis EC Number: 2.3.1.85 Confidence Level: 4 AUTHORS: PMID:11756679,PMID:15507492,PMID:2669958 NOTES:
fast: false
modifier: MODEL1310110061#
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110061#_f6c947ab_90c2_42ca_b8f1_3960beacb071
is: SBO:0000252
initial concentration: NaN
constant: false
is encoded by: hsa:54407
type: Species
is: Q96QD8
initial amount: NaN
boundary condition: true
has only substance units: false
name: SLC38A2

http://identifiers.org/biomodels.db/MODEL1310110061#_b1e77319_babc_4085_8ecf_501f1e9daffc
is encoded by: hsa:8876
initial amount: NaN
is: O95497
has only substance units: false
name: VNN1
is: SBO:0000252
type: Species
initial concentration: NaN
boundary condition: true
constant: false

metaR EX q10 LPAREN e RPAREN
kinetic law: MODEL1310110061#
reactant: MODEL1310110061#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for ubiquinone
type: Reaction

metaR r0669
reactant: MODEL1310110061#
kinetic law: MODEL1310110061#
is described by: ECO:0000000
name: (S)-3-Hydroxyisobutyryl-CoA hydro-lyase Valine, leucine and isoleucine degradation EC:4.2.1.17
reversible: false
product: MODEL1310110061#
notes: GENE_ASSOCIATION: SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 4.2.1.17 Confidence Level: 0 AUTHORS: PMID:10671535,PMID:12467702 NOTES:
type: Reaction
fast: false
is: SBO:0000176

metaR GLNTHRNaEx
name: L-threonine/L-glutamine Na-dependent exchange (Gln-L in)
kinetic law: MODEL1310110061#
is: SBO:0000185
fast: false
type: Reaction
reactant: MODEL1310110061#
reversible: false
modifier: MODEL1310110061#
product: MODEL1310110061#
notes: GENE_ASSOCIATION: (6510.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14530974 NOTES:SAB see Kanai and Hediger 2004 (2003), PMID 14530974
is described by: ECO:0000269

http://identifiers.org/biomodels.db/MODEL1310110061#_56bb29f2_1c74_41bf_9dd9_e9ee2810c3de
has only substance units: false
type: Species
is: Q8N5Z0
boundary condition: true
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:51166
is: SBO:0000252
constant: false
name: AADAT

metaM HC00591 m
initial amount: NaN
is: SBO:0000247
has only substance units: false
boundary condition: false
is: CHEBI:16769
constant: false
notes: FORMULA: C5H6NO4 CHARGE: -1 INCHI: InChI=1S/C5H7NO4/c6-4(8)2-1-3(7)5(9)10/h1-2H2,(H2,6,8)(H,9,10)/p-1 EHMN_ABBREVIATION: C00940
type: Species
name: 2-oxoglutaramate
initial concentration: 1.0

metaR LPS3e
is: SBO:0000176
notes: GENE_ASSOCIATION: (3990.1) SUBSYSTEM: Fatty acid oxidation EC Number: 3.1.1.23 Confidence Level: 2 AUTHORS: PMID:14630921 NOTES:NJ
is described by: ECO:0000000
type: Reaction
fast: false
modifier: MODEL1310110061#
reactant: MODEL1310110061#
kinetic law: MODEL1310110061#
reversible: false
is version of: http://identifiers.org/ec-code/3.1.1.3
name: lipase, extracellular
product: MODEL1310110061#

metaR RDH1a
modifier: MODEL1310110061#
is: SBO:0000176
reactant: MODEL1310110061#
is described by: ECO:0000269
fast: false
type: Reaction
product: MODEL1310110061#
notes: GENE_ASSOCIATION: (157506.1) or (112724.1) or (145226.1) or (51109.1) or (195814.1) or (57665.1) or (50700.1) SUBSYSTEM: Vitamin A metabolism EC Number: 1.1.1.105 Confidence Level: 4 AUTHORS: PMID:12226107,PMID:12372410,PMID:12407145,PMID:1503811,PMID:15258582,PMID:15322982 NOTES:IT
is version of: http://identifiers.org/ec-code/1.1.1.300
is version of: http://identifiers.org/ec-code/1.1.1.105
name: retinol dehydrogenase (all-trans,NADPH)
kinetic law: MODEL1310110061#
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110061#_91d5fdf7_b87a_4aea_a7c5_36e9b09c247a
is: P43353
is encoded by: hsa:221
has only substance units: false
type: Species
is: SBO:0000252
constant: false
name: ALDH3B1
initial concentration: NaN
initial amount: NaN
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110061#_8e407f8a_fb06_4c02_b689_3f9e9d812b2d
constant: false
name: CYP27A1
has only substance units: false
is: Q02318
boundary condition: true
initial concentration: NaN
is encoded by: hsa:1593
type: Species
initial amount: NaN
is: SBO:0000252

metaM 3dpdhb m
notes: FORMULA: C57H85O4 CHARGE: -1 INCHI: InChI=1S/C57H86O4/c1-43(2)21-12-22-44(3)23-13-24-45(4)25-14-26-46(5)27-15-28-47(6)29-16-30-48(7)31-17-32-49(8)33-18-34-50(9)35-19-36-51(10)37-20-38-52(11)39-40-53-41-54(57(60)61)42-55(58)56(53)59/h21,23,25,27,29,31,33,35,37,39,41-42,58-59H,12-20,22,24,26,28,30,32,34,36,38,40H2,1-11H3,(H,60,61)/b44-23+,45-25+,46-27+,47-29+,48-31+,49-33+,50-35+,51-37+,52-39+
is: CHEBI:50775
name: 3-Decaprenyl-4,5-dihdydroxybenzoate
has only substance units: false
constant: false
type: Species
initial concentration: 1.0
boundary condition: false
initial amount: NaN
is: SBO:0000247

metaR EX pchol hs LPAREN e RPAREN
kinetic law: MODEL1310110061#
reactant: MODEL1310110061#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Phosphatidylcholine (homo sapiens) exchange
type: Reaction

metaM tststerone c
initial concentration: 1.0
boundary condition: false
is: SBO:0000247
is: CHEBI:17347
name: testosterone
is: HMDB00234
type: Species
has only substance units: false
notes: FORMULA: C19H28O2 CHARGE: 0 INCHI: InChI=1S/C19H28O2/c1-18-9-7-13(20)11-12(18)3-4-14-15-5-6-17(21)19(15,2)10-8-16(14)18/h11,14-17,21H,3-10H2,1-2H3/t14-,15-,16-,17-,18-,19-/m0/s1 EHMN_ABBREVIATION: C00535
constant: false
initial amount: NaN

metaM 2mb2coa m
has only substance units: false
initial amount: NaN
notes: FORMULA: C26H38N7O17P3S CHARGE: -4 INCHI: InChI=1S/C26H42N7O17P3S/c1-5-14(2)25(38)54-9-8-28-16(34)6-7-29-23(37)20(36)26(3,4)11-47-53(44,45)50-52(42,43)46-10-15-19(49-51(39,40)41)18(35)24(48-15)33-13-32-17-21(27)30-12-31-22(17)33/h5,12-13,15,18-20,24,35-36H,6-11H2,1-4H3,(H,28,34)(H,29,37)(H,42,43)(H,44,45)(H2,27,30,31)(H2,39,40,41)/p-4/b14-5+/t15-,18-,19-,20+,24-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01102 EHMN_ABBREVIATION: C03345
is: CHEBI:57337
initial concentration: 1.0
type: Species
name: 2-methylcrotonoyl-CoA(4-)
boundary condition: false
is: SBO:0000247
constant: false
is: HMDB02054

metaR CHOLK
is: SBO:0000176
fast: false
reactant: MODEL1310110061#
is version of: http://identifiers.org/ec-code/2.7.1.32
product: MODEL1310110061#
type: Reaction
name: Choline kinase
is described by: ECO:0000269
reversible: false
notes: GENE_ASSOCIATION: (1120.2) or (1119.1) or (1120.1) or (1119.2) SUBSYSTEM: Glycerophospholipid metabolism EC Number: Confidence Level: 4 AUTHORS: NOTES:
modifier: MODEL1310110061#
kinetic law: MODEL1310110061#

metaM accoa n
has only substance units: false
initial concentration: 1.0
constant: false
notes: FORMULA: C23H34N7O17P3S CHARGE: -4 INCHI: InChI=1S/C23H38N7O17P3S/c1-12(31)51-7-6-25-14(32)4-5-26-21(35)18(34)23(2,3)9-44-50(41,42)47-49(39,40)43-8-13-17(46-48(36,37)38)16(33)22(45-13)30-11-29-15-19(24)27-10-28-20(15)30/h10-11,13,16-18,22,33-34H,4-9H2,1-3H3,(H,25,32)(H,26,35)(H,39,40)(H,41,42)(H2,24,27,28)(H2,36,37,38)/p-4/t13-,16-,17-,18+,22-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00033 EHMN_ABBREVIATION: C00024
is: SBO:0000247
boundary condition: false
initial amount: NaN
type: Species
name: acetyl-CoA(4-)
is: CHEBI:57288
is: HMDB01206

metaM HC01434 m
is: CHEBI:58931
constant: false
initial concentration: 1.0
type: Species
boundary condition: false
name: oxalatosuccinate(3-)
has only substance units: false
is: SBO:0000247
initial amount: NaN
notes: FORMULA: C6H3O7 CHARGE: -3 INCHI: InChI=1S/C6H6O7/c7-3(8)1-2(5(10)11)4(9)6(12)13/h2H,1H2,(H,7,8)(H,10,11)(H,12,13)/p-3 EHMN_ABBREVIATION: C05379

http://identifiers.org/biomodels.db/MODEL1310110061#_d86b2faa_2578_4ee1_8d3d_6290e40d9727
has only substance units: false
initial concentration: NaN
name: PPA2
type: Species
constant: false
boundary condition: true
initial amount: NaN
is: SBO:0000252
is: F8WDN9
is encoded by: hsa:27068

http://identifiers.org/biomodels.db/MODEL1310110061#_64b4dca0_971c_46c0_95e8_db4a37a5d34e
has only substance units: false
type: Species
initial amount: NaN
name: SLC35D1
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:23169
boundary condition: true
constant: false
is: Q9NTN3

metaM occoa c
type: Species
initial concentration: 1.0
constant: false
has only substance units: false
name: Octanoyl-CoA (n-C8:0CoA)
is: SBO:0000247
is: C01944
initial amount: NaN
is: HMDB01070
is: CHEBI:57386
boundary condition: false
notes: FORMULA: C29H46N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00869 EHMN_ABBREVIATION: C01944

http://identifiers.org/biomodels.db/MODEL1310110061#_bffa40d6_34ac_4cc7_97b4_d3f27921210a
is: E7EPT3
name: ALDH7A1
initial amount: NaN
is encoded by: hsa:501
initial concentration: NaN
type: Species
boundary condition: true
constant: false
has only substance units: false
is: SBO:0000252

metaR URIt5le
type: Reaction
reactant: MODEL1310110061#
reversible: false
fast: false
product: MODEL1310110061#
is described by: ECO:0000134
name: uridine transport in via sodium symport (1:2)
kinetic law: MODEL1310110061#
modifier: MODEL1310110061#
notes: GENE_ASSOCIATION: (64078.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
is: SBO:0000185

metaR r0730
reversible: false
modifier: MODEL1310110061#
type: Reaction
fast: false
notes: GENE_ASSOCIATION: (34.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.1.1.211 Confidence Level: 0 AUTHORS: PMID:10231530,PMID:10329704,PMID:1550553,PMID:1651711,PMID:7150615,PMID:8188243,PMID:8687463,PMID:9553139 NOTES:
is version of: http://identifiers.org/ec-code/1.3.99.3
name: (S)-Hydroxyoctanoyl-CoA:NAD+ oxidoreductase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:1.1.1.211
reactant: MODEL1310110061#
kinetic law: MODEL1310110061#
is: SBO:0000176
is described by: ECO:0000000
product: MODEL1310110061#

metaR BILIRUBtr
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: NOTES:cholesterol precursor, transport by "diffusion" -> actually beleived to be flip-flop mechanism (PMID: 12840657). NJ
is: SBO:0000185
is described by: ECO:0000000
reversible: true
product: MODEL1310110061#
type: Reaction
reactant: MODEL1310110061#
fast: false
kinetic law: MODEL1310110061#
name: lipid, flip-flop intracellular transport

metaM ump g
type: Species
is: SBO:0000247
has only substance units: false
constant: false
is: CHEBI:57865
is: HMDB00288
initial amount: NaN
boundary condition: false
name: UMP(2-)
notes: FORMULA: C9H11N2O9P CHARGE: -2 INCHI: InChI=1S/C9H13N2O9P/c12-5-1-2-11(9(15)10-5)8-7(14)6(13)4(20-8)3-19-21(16,17)18/h1-2,4,6-8,13-14H,3H2,(H,10,12,15)(H2,16,17,18)/p-2/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00105 EHMN_ABBREVIATION: C00105
initial concentration: 1.0

metaR PMANM
reversible: true
kinetic law: MODEL1310110061#
is version of: http://identifiers.org/ec-code/5.4.2.8
fast: false
is version of: http://identifiers.org/ec-code/5.4.2.2
modifier: MODEL1310110061#
is: SBO:0000176
name: phosphomannomutase
type: Reaction
reactant: MODEL1310110061#
notes: GENE_ASSOCIATION: (5372.1) or (55276.1) or (5373.1) SUBSYSTEM: Fructose and mannose metabolism EC Number: 5.4.2.8 Confidence Level: 0 AUTHORS: NOTES:
is described by: ECO:0000000
product: MODEL1310110061#

metaR r1078
is described by: ECO:0000000
fast: false
reversible: false
kinetic law: MODEL1310110061#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:10049700,PMID:10574970,PMID:11389679,PMID:11557028,PMID:11564694,PMID:12824232,PMID:12930836,PMID:14574404,PMID:16288981,PMID:911815 NOTES:
type: Reaction
name: Vesicular transport
reactant: MODEL1310110061#
is: SBO:0000185
product: MODEL1310110061#

metaR r0410
kinetic law: MODEL1310110061#
product: MODEL1310110061#
reactant: MODEL1310110061#
fast: false
type: Reaction
is: SBO:0000176
is described by: ECO:0000000
name: 2-Deoxyguanosine 5-triphosphate pyrophosphohydrolase Purine metabolism EC:3.6.1.19
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Pyrimidine catabolism EC Number: 3.6.1.19 Confidence Level: 0 AUTHORS: PMID:15652174,PMID:16752921,PMID:17095758 NOTES:

metaR PROSTGD2t
reactant: MODEL1310110061#
type: Reaction
is: SBO:0000185
product: MODEL1310110061#
notes: GENE_ASSOCIATION: (6578.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12507753,PMID:8787677,PMID:9334206 NOTES:NJ
is described by: ECO:0000269
reversible: true
kinetic law: MODEL1310110061#
fast: false
modifier: MODEL1310110061#
name: prostaglandin transport via bicarbonate countertransport

metaR TRPt
fast: false
notes: GENE_ASSOCIATION: (117247.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:11827462 NOTES:
name: L-tryptophan transport
reactant: MODEL1310110061#
is: SBO:0000185
modifier: MODEL1310110061#
product: MODEL1310110061#
is described by: ECO:0000269
type: Reaction
reversible: true
kinetic law: MODEL1310110061#

http://identifiers.org/biomodels.db/MODEL1310110061#_d9ca9047_b94b_4a6c_8e1a_5cb45a254094
boundary condition: true
is encoded by: hsa:3081
has only substance units: false
constant: false
is: Q93099
type: Species
initial amount: NaN
name: HGD
is: SBO:0000252
initial concentration: NaN

metaM gluside hs c
is: CHEBI:18368
has only substance units: false
initial concentration: 1.0
type: Species
boundary condition: false
initial amount: NaN
name: D-glucosyl-N-acylsphingosine
notes: FORMULA: C24H46NO7FULLRCO CHARGE: 0 EHMN_ABBREVIATION: C01190
is: SBO:0000247
constant: false

metaM pd3 c
constant: false
has only substance units: false
initial amount: NaN
name: Previtamin D3
notes: FORMULA: C27H44O CHARGE: 0 INCHI: InChI=1/C27H44O/c1-19(2)8-6-9-21(4)25-15-16-26-22(10-7-17-27(25,26)5)12-13-23-18-24(28)14-11-20(23)3/h10,12-13,19,21,24-26,28H,6-9,11,14-18H2,1-5H3/b13-12-/t21-,24+,25-,26?,27-/m1/s1
initial concentration: 1.0
is: HMDB06500
is: SBO:0000247
type: Species
boundary condition: false

metaR LEUTA
modifier: MODEL1310110061#
is version of: http://identifiers.org/ec-code/2.6.1.42
type: Reaction
reversible: true
is described by: ECO:0000269
reactant: MODEL1310110061#
kinetic law: MODEL1310110061#
is: SBO:0000176
name: leucine transaminase
notes: GENE_ASSOCIATION: (586.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 2.6.1.6 Confidence Level: 4 AUTHORS: PMID:6933702,PMID:9165094 NOTES:_2.6.1.42
product: MODEL1310110061#
fast: false

http://identifiers.org/biomodels.db/MODEL1310110061#_037f7897_0561_4ea4_9d3a_fa2a877c3034
is: P11310
constant: false
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:34
type: Species
boundary condition: true
has only substance units: false
name: ACADM
is: SBO:0000252

metaR DNDPt15m
type: Reaction
modifier: MODEL1310110061#
kinetic law: MODEL1310110061#
product: MODEL1310110061#
name: dUDP transport via dGDP antiport
is described by: ECO:0000269
is: SBO:0000185
reversible: false
reactant: MODEL1310110061#
notes: GENE_ASSOCIATION: (60386.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:11226231 NOTES:IT
fast: false

metaR r0731
reactant: MODEL1310110061#
name: (S)-Hydroxyoctanoyl-CoA hydro-lyase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:4.2.1.17
reversible: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.17 Confidence Level: 0 AUTHORS: PMID:8012501,PMID:8188243 NOTES:
kinetic law: MODEL1310110061#
fast: false
is: SBO:0000176
is described by: ECO:0000000
product: MODEL1310110061#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110061#_8709b13a_f767_4df0_acbe_5d5634f628b2
has only substance units: false
is encoded by: hsa:5295
name: PIK3CA:PIK3R1
initial amount: NaN
is: SBO:0000297
type: Species
has part: P27986
boundary condition: true
constant: false
initial concentration: NaN

metaR THYOXt
type: Reaction
fast: false
is: SBO:0000185
reactant: MODEL1310110061#
name: T4 transport via bicarbonate countertransport
product: MODEL1310110061#
notes: GENE_ASSOCIATION: (53919.1) or (6579.1) or (28231.1) or (10599.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12507753,PMID:9007731,PMID:9334206 NOTES:NJ
is described by: ECO:0000269
kinetic law: MODEL1310110061#
reversible: true
modifier: MODEL1310110061#

metaR r1433
kinetic law: MODEL1310110061#
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 1.8.1.9 Confidence Level: 0 AUTHORS: PMID:5553404,PMID:5671058 NOTES:
type: Reaction
fast: false
reactant: MODEL1310110061#
product: MODEL1310110061#
reversible: false
name: NADPH:oxidized-thioredoxin oxidoreductase Pyrimidine metabolism EC:1.8.1.9
is described by: ECO:0000000

metaM malcoa e
is: CHEBI:57384
name: malonyl-CoA(4-)
notes: FORMULA: C24H33N7O19P3S CHARGE: -5 INCHI: InChI=1S/C24H38N7O19P3S/c1-24(2,19(37)22(38)27-4-3-13(32)26-5-6-54-15(35)7-14(33)34)9-47-53(44,45)50-52(42,43)46-8-12-18(49-51(39,40)41)17(36)23(48-12)31-11-30-16-20(25)28-10-29-21(16)31/h10-12,17-19,23,36-37H,3-9H2,1-2H3,(H,26,32)(H,27,38)(H,33,34)(H,42,43)(H,44,45)(H2,25,28,29)(H2,39,40,41)/p-5/t12-,17-,18-,19+,23-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00086 EHMN_ABBREVIATION: C00083
initial concentration: 1.0
has only substance units: false
boundary condition: false
initial amount: NaN
is: SBO:0000247
is: HMDB01175
type: Species
constant: false

metaR RE3242R
fast: false
name: RE3242
reversible: true
modifier: MODEL1310110061#
reactant: MODEL1310110061#
product: MODEL1310110061#
notes: GENE_ASSOCIATION: (64834.1) SUBSYSTEM: Fatty acid synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:10970790 NOTES:
is: SBO:0000176
type: Reaction
kinetic law: MODEL1310110061#
is described by: ECO:0000000

metaM bildglcur r
is: HMDB03325
type: Species
is: SBO:0000247
is: CHEBI:58471
name: bis(beta-glucosyluronate)bilirubin
notes: FORMULA: C45H50N4O18 CHARGE: -2 INCHI: InChI=1S/C45H52N4O18/c1-7-20-19(6)40(58)49-27(20)14-25-18(5)23(10-12-31(51)65-45-37(57)33(53)35(55)39(67-45)43(62)63)29(47-25)15-28-22(17(4)24(46-28)13-26-16(3)21(8-2)41(59)48-26)9-11-30(50)64-44-36(56)32(52)34(54)38(66-44)42(60)61/h7-8,13-14,32-39,44-47,52-57H,1-2,9-12,15H2,3-6H3,(H,48,59)(H,49,58)(H,60,61)(H,62,63)/p-2/b26-13+,27-14+/t32-,33-,34-,35-,36+,37+,38-,39-,44+,45+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01616 EHMN_ABBREVIATION: C05787
boundary condition: false
has only substance units: false
initial amount: NaN
initial concentration: 1.0
constant: false

http://identifiers.org/biomodels.db/MODEL1310110061#_941c23ac_f4e0_407a_8151_8d047cbe40ea
initial concentration: NaN
is encoded by: hsa:84532
constant: false
is: Q9NUB1
is: SBO:0000252
has only substance units: false
name: ACSS1
boundary condition: true
initial amount: NaN
type: Species

metaR DCMPDA
modifier: MODEL1310110061#
reversible: true
is described by: ECO:0000254
is: SBO:0000176
type: Reaction
name: dCMP deaminase
notes: GENE_ASSOCIATION: (1635.1) SUBSYSTEM: Pyrimidine catabolism EC Number: 3.5.4.12 Confidence Level: 2 AUTHORS: PMID:7642519,PMID:7685356 NOTES:NCD
fast: false
is version of: http://identifiers.org/ec-code/3.5.4.12
reactant: MODEL1310110061#
product: MODEL1310110061#
kinetic law: MODEL1310110061#

metaR PHETHPTOX2
name: L-Phenylalanine,tetrahydrobiopterin:oxygen oxidoreductase (4-hydroxylating)
notes: GENE_ASSOCIATION: (5053.1) SUBSYSTEM: Phenylalanine metabolism EC Number: 1.14.16.1 Confidence Level: 4 AUTHORS: PMID:10727395,PMID:9450897 NOTES:SAB unlumped form of PHETHPTOX according to PMID 10727395
is version of: http://identifiers.org/ec-code/1.14.16.1
type: Reaction
product: MODEL1310110061#
is described by: ECO:0000269
reversible: false
is: SBO:0000176
modifier: MODEL1310110061#
fast: false
kinetic law: MODEL1310110061#
reactant: MODEL1310110061#

http://identifiers.org/biomodels.db/MODEL1310110061#_2f65ce8e_f0e7_497b_bcad_aaa826ff1087
name: PIK3CA
boundary condition: true
has only substance units: false
initial amount: NaN
is: P42336
is: SBO:0000252
is encoded by: hsa:5290
type: Species
initial concentration: NaN
constant: false

metaM dad 2 e
is: SBO:0000247
initial concentration: 1.0
boundary condition: false
constant: false
is: HMDB00101
initial amount: NaN
type: Species
is: CHEBI:17256
notes: FORMULA: C10H13N5O3 CHARGE: 0 INCHI: InChI=1S/C10H13N5O3/c11-9-8-10(13-3-12-9)15(4-14-8)7-1-5(17)6(2-16)18-7/h3-7,16-17H,1-2H2,(H2,11,12,13)/t5-,6+,7+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00431
has only substance units: false
name: 2-deoxyadenosine

http://identifiers.org/biomodels.db/MODEL1310110061#_9b43f181_1bba_4b85_9ec8_cc67cc485544
type: Species
initial concentration: NaN
has only substance units: false
constant: false
initial amount: NaN
is: SBO:0000252
is encoded by: hsa:3251
name: HPRT1
is: P00492
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110061#_ed40136f_cf20_475c_8762_41f37f57f82d
boundary condition: true
is: SBO:0000252
has only substance units: false
constant: false
type: Species
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:BC005314
name: _BC005314_1_x

metaR r0186
name: Ethanolamine-phosphate phospho-lyase (deaminating) EC:4.2.3.2
type: Reaction
kinetic law: MODEL1310110061#
is version of: http://identifiers.org/ec-code/1.2.1.5
modifier: MODEL1310110061#
reversible: false
product: MODEL1310110061#
reactant: MODEL1310110061#
notes: GENE_ASSOCIATION: (220.1) or (218.1) or (221.1) or (222.1) or (U37519.1) SUBSYSTEM: Glycerophospholipid metabolism EC Number: 4.2.3.2 Confidence Level: 0 AUTHORS: PMID:5498429 NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false

metaR ACACT1r
name: acetyl-CoA C-acetyltransferase
is version of: http://identifiers.org/ec-code/2.3.1.9
type: Reaction
reversible: true
kinetic law: MODEL1310110061#
fast: false
notes: GENE_ASSOCIATION: (39.1) SUBSYSTEM: Tryptophan metabolism EC Number: 2.3.1.9 Confidence Level: 0 AUTHORS: NOTES:JLR- reversible form of ACACT1
is described by: ECO:0000000
product: MODEL1310110061#
is: SBO:0000176
reactant: MODEL1310110061#
modifier: MODEL1310110061#

http://identifiers.org/biomodels.db/MODEL1310110061#_161965f5_aa7f_4e6d_8e87_86775fe68660
is encoded by: hsa:29085
has only substance units: false
boundary condition: true
constant: false
initial amount: NaN
is: SBO:0000252
is: Q9P019
type: Species
name: PHPT1
initial concentration: NaN

metaR r0732
reactant: MODEL1310110061#
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.16 Confidence Level: 0 AUTHORS: PMID:1121274,PMID:1679347,PMID:3194209,PMID:6378901,PMID:8241273 NOTES:
name: Hexanoyl-CoA:acetyl-CoA C-acyltransferase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:2.3.1.16
product: MODEL1310110061#
reversible: false
is: SBO:0000176
is described by: ECO:0000000
fast: false
kinetic law: MODEL1310110061#
type: Reaction

metaR DMATTx
is described by: ECO:0000134
is version of: http://identifiers.org/ec-code/2.5.1.1
product: MODEL1310110061#
type: Reaction
reversible: false
name: dimethylallyltranstransferase
modifier: MODEL1310110061#
is: SBO:0000176
notes: GENE_ASSOCIATION: (2224.1) SUBSYSTEM: Cholesterol metabolism EC Number: 2.5.1.1 Confidence Level: 4 AUTHORS: PMID:8188698 NOTES:peroxisomal version - NJ
fast: false
reactant: MODEL1310110061#
kinetic law: MODEL1310110061#

metaM ump e
has only substance units: false
type: Species
is: CHEBI:57865
is: SBO:0000247
boundary condition: false
constant: false
name: UMP(2-)
is: HMDB00288
initial amount: NaN
notes: FORMULA: C9H11N2O9P CHARGE: -2 INCHI: InChI=1S/C9H13N2O9P/c12-5-1-2-11(9(15)10-5)8-7(14)6(13)4(20-8)3-19-21(16,17)18/h1-2,4,6-8,13-14H,3H2,(H,10,12,15)(H2,16,17,18)/p-2/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00105 EHMN_ABBREVIATION: C00105
initial concentration: 1.0

metaR PCHOLHSTDe
kinetic law: MODEL1310110061#
product: MODEL1310110061#
reactant: MODEL1310110061#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: PCHOLHSTDe
type: Reaction

metaM L2aadp6sa c
is: SBO:0000247
boundary condition: false
type: Species
constant: false
is: HMDB01263
notes: FORMULA: C6H11NO3 CHARGE: 0 INCHI: InChI=1S/C6H11NO3/c7-5(6(9)10)3-1-2-4-8/h4-5H,1-3,7H2,(H,9,10)/t5-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01230 EHMN_ABBREVIATION: C04076
initial amount: NaN
initial concentration: 1.0
name: L-allysine
is: CHEBI:17917
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110061#_e4b52727_7f59_43af_af1a_28208ce93e0a
constant: false
is encoded by: hsa:26266
boundary condition: true
initial concentration: NaN
is: Q9UKG4
initial amount: NaN
type: Species
name: SLC13A4
has only substance units: false
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110061#_df9c947d_9403_4392_9cc9_f21d6b5e902b
initial amount: NaN
type: Species
constant: false
name: CEPT1
is encoded by: hsa:10390
initial concentration: NaN
is: SBO:0000252
boundary condition: true
is: B3KN25
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110061#_f2ad5bb2_3f55_4f8c_839f_8eb1d3613335
is encoded by: hsa:8898
is: SBO:0000252
is: A6NN98
initial amount: NaN
type: Species
boundary condition: true
initial concentration: NaN
name: MTMR2
constant: false
has only substance units: false

metaR EX lgnc LPAREN e RPAREN
kinetic law: MODEL1310110061#
reactant: MODEL1310110061#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: lignoceric acid exchange
type: Reaction

metaR GLNALANaEx
is described by: ECO:0000269
reactant: MODEL1310110061#
type: Reaction
is: SBO:0000185
reversible: false
kinetic law: MODEL1310110061#
notes: GENE_ASSOCIATION: (6510.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14530974 NOTES:SAB see Kanai and Hediger 2004 (2003), PMID 14530974
fast: false
name: L-alanine/L-glutamine Na-dependent exchange (Gln-L in)
modifier: MODEL1310110061#
product: MODEL1310110061#

http://identifiers.org/biomodels.db/MODEL1310110061#_64449250_b527_43b9_a635_b50c40babb58
name: B3GALNT1
is encoded by: hsa:8706
initial amount: NaN
boundary condition: true
is: SBO:0000252
is: Q49AT3
initial concentration: NaN
constant: false
has only substance units: false
type: Species

metaR EX arg L LPAREN e RPAREN
kinetic law: MODEL1310110061#
reactant: MODEL1310110061#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: L-Arginine exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110061#_13a08c09_0335_4e46_929c_afde5964ac80
is: SBO:0000252
initial amount: NaN
has only substance units: false
boundary condition: true
initial concentration: NaN
is encoded by: hsa:9962
type: Species
name: SLC23A2
constant: false

metaM ivcoa m
initial amount: NaN
boundary condition: false
notes: FORMULA: C26H40N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC01021 EHMN_ABBREVIATION: C02939
has only substance units: false
initial concentration: 1.0
name: Isovaleryl-CoA
is: CHEBI:57345
is: HMDB01113
is: SBO:0000247
constant: false
type: Species

metaM HC01231 c
notes: FORMULA: C12H21N2O6S CHARGE: -1 INCHI: InChI=1S/C12H22N2O6S/c1-12(2,6-15)9(17)10(18)13-4-3-8(16)14-7(5-21)11(19)20/h7,9,15,17,21H,3-6H2,1-2H3,(H,13,18)(H,14,16)(H,19,20)/p-1/t7-,9-/m0/s1 EHMN_ABBREVIATION: C04079
has only substance units: false
boundary condition: false
constant: false
type: Species
is: SBO:0000247
initial concentration: 1.0
initial amount: NaN
is: CHEBI:58480
name: N-[(R)-pantothenoyl]-L-cysteinate

http://identifiers.org/biomodels.db/MODEL1310110061#_b57f689b_5470_48bc_a834_69992e34f390
boundary condition: true
is: P04035
is: SBO:0000252
has only substance units: false
initial amount: NaN
is encoded by: hsa:3156
name: HMGCR
constant: false
initial concentration: NaN
type: Species

metaR TPI
is described by: ECO:0000134
kinetic law: MODEL1310110061#
reactant: MODEL1310110061#
fast: false
notes: GENE_ASSOCIATION: (7167.1) or (286016.1) SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: 5.3.1.1 Confidence Level: 0 AUTHORS: PMID:18456264,PMID:18840520,PMID:2579079,PMID:999837 NOTES:SMP. 18840520 - expression data; 18456264 - protein purification; 2579079 - genetic, homology; 999837 - biochemical
modifier: MODEL1310110061#
product: MODEL1310110061#
name: triose-phosphate isomerase
type: Reaction
is: SBO:0000176
is version of: http://identifiers.org/ec-code/5.3.1.1
reversible: true

metaR r0733
fast: false
notes: GENE_ASSOCIATION: (8659.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.1.1.35 Confidence Level: 0 AUTHORS: PMID:10231530,PMID:10329704,PMID:1550553,PMID:1651711,PMID:7150615,PMID:8188243,PMID:8687463,PMID:9553139 NOTES:
product: MODEL1310110061#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.5.1.12
is described by: ECO:0000000
name: (S)-Hydroxyhexanoyl-CoA:NAD+ oxidoreductase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:1.1.1.211 EC:1.1.1.35
kinetic law: MODEL1310110061#
type: Reaction
modifier: MODEL1310110061#
reversible: false
reactant: MODEL1310110061#

metaM kdnp c
has only substance units: false
initial concentration: 1.0
is: CHEBI:17369
notes: FORMULA: C9H14O12P CHARGE: -3
name: 2-keto-3-deoxy-D-glycero-D-galactononic acid 9-phosphate
is: SBO:0000247
constant: false
is: HMDB01078
initial amount: NaN
type: Species
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110061#_3f469e9d_7505_4451_a727_c0f74a933fdd
initial amount: NaN
name: SLC36A1
is: Q1LZ56
constant: false
is: SBO:0000252
initial concentration: NaN
has only substance units: false
boundary condition: true
is encoded by: hsa:206358
type: Species

metaM Tn antigen g
name: Tn antigen
has only substance units: false
boundary condition: false
initial concentration: 1.0
initial amount: NaN
type: Species
is: C04383
is: SBO:0000247
constant: false
notes: FORMULA: C8H14NO5X CHARGE: 0

metaM pheacgln c
is: CHEBI:58310
initial concentration: 1.0
is: HMDB06344
has only substance units: false
initial amount: NaN
constant: false
is: SBO:0000247
name: (2S)-4-carbamoyl-2-(2-phenylacetamido)butanoate
boundary condition: false
type: Species
notes: FORMULA: C13H16N2O4 CHARGE: 0 INCHI: InChI=1S/C13H16N2O4/c14-11(16)7-6-10(13(18)19)15-12(17)8-9-4-2-1-3-5-9/h1-5,10H,6-8H2,(H2,14,16)(H,15,17)(H,18,19)/p-1/t10-/m0/s1

http://identifiers.org/biomodels.db/MODEL1310110061#_66540e24_cf45_4956_bab9_8529202f5f33
is: SBO:0000252
has only substance units: false
name: GALNT8
initial concentration: NaN
is: Q9NY28
initial amount: NaN
is encoded by: hsa:26290
type: Species
boundary condition: true
constant: false

metaM 3pg c
initial concentration: 1.0
is: http://identifiers.org/pubchem.compound/3497
type: Species
name: 3-Phospho-D-glycerate
has only substance units: false
is: CHEBI:58272
constant: false
is: SBO:0000247
is: HMDB00807
initial amount: NaN
is: C00197
boundary condition: false

metaM gtp n
initial concentration: 1.0
is: HMDB01273
is: SBO:0000247
is: CHEBI:37565
constant: false
notes: FORMULA: C10H12N5O14P3 CHARGE: -4 INCHI: InChI=1S/C10H16N5O14P3/c11-10-13-7-4(8(18)14-10)12-2-15(7)9-6(17)5(16)3(27-9)1-26-31(22,23)29-32(24,25)28-30(19,20)21/h2-3,5-6,9,16-17H,1H2,(H,22,23)(H,24,25)(H2,19,20,21)(H3,11,13,14,18)/p-4/t3-,5-,6-,9-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00051 EHMN_ABBREVIATION: C00044
name: GTP(4-)
type: Species
has only substance units: false
boundary condition: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110061#_eccb001a_db5b_4cb4_85a2_1d12e1028d07
constant: false
type: Species
boundary condition: true
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:55753
is: Q9ULD0
has only substance units: false
initial amount: NaN
name: OGDHL

metaM adn e
initial concentration: 1.0
boundary condition: false
name: Adenosine
is: SBO:0000247
is: HMDB00050
constant: false
notes: FORMULA: C10H13N5O4 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00196 EHMN_ABBREVIATION: C00212
has only substance units: false
is: C00212
initial amount: NaN
is: CHEBI:16335
type: Species

http://identifiers.org/biomodels.db/MODEL1310110061#_9d2eae17_dbbe_4f37_b8dd_815a237cf4d9
constant: false
has only substance units: false
is encoded by: hsa:NM 001929
boundary condition: true
initial amount: NaN
is: SBO:0000252
initial concentration: NaN
type: Species
name: _NM_001929_1_c

http://identifiers.org/biomodels.db/MODEL1310110061#_5bb838e7_6be4_4471_8a1c_3d11a5ebfee5
constant: false
is: SBO:0000252
initial concentration: NaN
name: QDPR
initial amount: NaN
type: Species
is: P09417
has only substance units: false
is encoded by: hsa:5860
boundary condition: true

metaR NDP7er
reversible: false
is: SBO:0000176
kinetic law: MODEL1310110061#
name: nucleoside-diphosphatase (UDP), endoplasmic reticulum
product: MODEL1310110061#
notes: GENE_ASSOCIATION: SUBSYSTEM: Nucleotide interconversion EC Number: 3.6.1.6 Confidence Level: 2 AUTHORS: PMID:10369669 NOTES:NCD
fast: false
type: Reaction
reactant: MODEL1310110061#
is described by: ECO:0000000

metaM dad 2 c
initial amount: NaN
notes: FORMULA: C10H13N5O3 CHARGE: 0 INCHI: InChI=1S/C10H13N5O3/c11-9-8-10(13-3-12-9)15(4-14-8)7-1-5(17)6(2-16)18-7/h3-7,16-17H,1-2H2,(H2,11,12,13)/t5-,6+,7+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00431
is: CHEBI:17256
boundary condition: false
type: Species
is: SBO:0000247
name: 2-deoxyadenosine
is: HMDB00101
has only substance units: false
initial concentration: 1.0
constant: false

metaM i c
constant: false
type: Species
is: SBO:0000247
has only substance units: false
is: HMDB12238
is: CHEBI:16382
initial concentration: 1.0
notes: FORMULA: I CHARGE: -1 INCHI: InChI=1S/HI/h1H/p-1 EHMN_ABBREVIATION: C00708
initial amount: NaN
boundary condition: false
name: iodide

metaM cdp e
initial amount: NaN
is: SBO:0000247
boundary condition: false
initial concentration: 1.0
constant: false
is: CHEBI:58069
type: Species
has only substance units: false
notes: FORMULA: C9H12N3O11P2 CHARGE: -3 INCHI: InChI=1S/C9H15N3O11P2/c10-5-1-2-12(9(15)11-5)8-7(14)6(13)4(22-8)3-21-25(19,20)23-24(16,17)18/h1-2,4,6-8,13-14H,3H2,(H,19,20)(H2,10,11,15)(H2,16,17,18)/p-3/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00110 EHMN_ABBREVIATION: C00112
is: HMDB01546
name: CDP(3-)

metaM xoltetrol c
type: Species
boundary condition: false
is: HMDB01231
has only substance units: false
is: SBO:0000247
is: CHEBI:17278
initial concentration: 1.0
constant: false
initial amount: NaN
name: 5beta-cholestane-3alpha,7alpha,12alpha,26-tetrol
notes: FORMULA: C27H48O4 CHARGE: 0 INCHI: InChI=1S/C27H48O4/c1-16(15-28)6-5-7-17(2)20-8-9-21-25-22(14-24(31)27(20,21)4)26(3)11-10-19(29)12-18(26)13-23(25)30/h16-25,28-31H,5-15H2,1-4H3/t16?,17-,18+,19-,20-,21+,22+,23-,24+,25+,26+,27-/m1/s1 EHMN_ABBREVIATION: C05446

http://identifiers.org/biomodels.db/MODEL1310110061#_9fbeb98d_1a85_4639_b041_4959c6c69a4c
has only substance units: false
constant: false
boundary condition: true
is encoded by: hsa:3939
has part: P00338
is: SBO:0000297
name: LDHA:LDHB
is encoded by: hsa:3945
has part: P07195
initial concentration: NaN
initial amount: NaN
type: Species

metaM dttp e
boundary condition: false
notes: FORMULA: C10H13N2O14P3 CHARGE: -4 INCHI: InChI=1S/C10H17N2O14P3/c1-5-3-12(10(15)11-9(5)14)8-2-6(13)7(24-8)4-23-28(19,20)26-29(21,22)25-27(16,17)18/h3,6-8,13H,2,4H2,1H3,(H,19,20)(H,21,22)(H,11,14,15)(H2,16,17,18)/p-4/t6-,7+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00368 EHMN_ABBREVIATION: C00459
is: CHEBI:37568
has only substance units: false
initial amount: NaN
name: dTTP(4-)
is: HMDB01342
initial concentration: 1.0
constant: false
is: SBO:0000247
type: Species

http://identifiers.org/biomodels.db/MODEL1310110061#_a122fd59_4761_4df5_a055_da63b28c8a7e
type: Species
is: SBO:0000252
constant: false
has only substance units: false
initial concentration: NaN
name: PTDSS2
boundary condition: true
initial amount: NaN
is encoded by: hsa:81490
is: Q9BVG9

metaR FAOXTC102C101m
kinetic law: MODEL1310110061#
product: MODEL1310110061#
reactant: MODEL1310110061#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation trans(C10:2-->C10:1)m
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110061#_251bb663_8b4a_40ae_b486_e52637aab2eb
is: GO:0005634
is: SBO:0000290
constant: false
size: 1.0
spatial dimensions: 3.0
name: nucleus
type: Compartment

metaR r1435
reversible: false
product: MODEL1310110061#
name: Transport reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:12930836,PMID:16288981,PMID:911815 NOTES:
type: Reaction
fast: false
reactant: MODEL1310110061#
kinetic law: MODEL1310110061#
is: SBO:0000185
is described by: ECO:0000000

metaM malcoa c
is: CHEBI:57384
initial concentration: 1.0
has only substance units: false
initial amount: NaN
is: C00083
is: HMDB01175
notes: FORMULA: C24H33N7O19P3S CHARGE: -5 HEPATONET_1.0_ABBREVIATION: HC00086 EHMN_ABBREVIATION: C00083
boundary condition: false
constant: false
type: Species
name: Malonyl-CoA
is: SBO:0000247

metaM gtp m
type: Species
is: C00044
has only substance units: false
name: GTP
initial amount: NaN
is: HMDB01273
is: SBO:0000247
notes: FORMULA: C10H12N5O14P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00051 EHMN_ABBREVIATION: C00044
boundary condition: false
initial concentration: 1.0
constant: false
is: CHEBI:37565

metaR PPItm
product: MODEL1310110061#
name: diphopshate transporter, mitochondrial
fast: false
kinetic law: MODEL1310110061#
reversible: true
is: SBO:0000185
type: Reaction
is described by: ECO:0000134
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 1 AUTHORS: added during gap-filling. NOTES:added during gap-filling.
reactant: MODEL1310110061#

metaR CHOLt4
modifier: MODEL1310110061#
is: SBO:0000185
product: MODEL1310110061#
kinetic law: MODEL1310110061#
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (60482.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:11027560,PMID:11068039,PMID:12675135 NOTES:NCD
fast: false
reactant: MODEL1310110061#
reversible: true
type: Reaction
name: choline, sodium cotransport

metaM srtn c
name: serotonin(1+)
type: Species
is: CHEBI:350546
constant: false
is: SBO:0000247
boundary condition: false
has only substance units: false
is: HMDB00259
initial amount: NaN
initial concentration: 1.0
notes: FORMULA: C10H13N2O CHARGE: 1 INCHI: InChI=1S/C10H12N2O/c11-4-3-7-6-12-10-2-1-8(13)5-9(7)10/h1-2,5-6,12-13H,3-4,11H2/p+1 HEPATONET_1.0_ABBREVIATION: HC00533 EHMN_ABBREVIATION: C00780

metaM q10 m
is: HMDB01072
name: ubiquinone-10
is: SBO:0000247
is: CHEBI:46245
initial concentration: 1.0
initial amount: NaN
notes: FORMULA: C59H90O4 CHARGE: 0 INCHI: InChI=1S/C59H90O4/c1-44(2)24-15-25-45(3)26-16-27-46(4)28-17-29-47(5)30-18-31-48(6)32-19-33-49(7)34-20-35-50(8)36-21-37-51(9)38-22-39-52(10)40-23-41-53(11)42-43-55-54(12)56(60)58(62-13)59(63-14)57(55)61/h24,26,28,30,32,34,36,38,40,42H,15-23,25,27,29,31,33,35,37,39,41,43H2,1-14H3/b45-26+,46-28+,47-30+,48-32+,49-34+,50-36+,51-38+,52-40+,53-42+ HEPATONET_1.0_ABBREVIATION: HC00329 EHMN_ABBREVIATION: C11378
type: Species
constant: false
boundary condition: false
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110061#_22c907d0_66eb_441e_bec8_46c1132e4907
initial amount: NaN
constant: false
name: BTD
initial concentration: NaN
has only substance units: false
boundary condition: true
is encoded by: hsa:686
is: P43251
is: SBO:0000252
type: Species

http://identifiers.org/biomodels.db/MODEL1310110061#_9dd12395_7f8e_4df9_aa7b_9b25fefc1ea7
initial amount: NaN
initial concentration: NaN
name: AK4
is: SBO:0000252
constant: false
has only substance units: false
is encoded by: hsa:205
boundary condition: true
type: Species

metaR EX crmp hs LPAREN e RPAREN
kinetic law: MODEL1310110061#
reactant: MODEL1310110061#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Ceramide 1-phosphate exchange
type: Reaction

metaR NCNt
name: Na+/Ca2+-NH4+ exchange
is described by: ECO:0000269
is: SBO:0000185
type: Reaction
reversible: true
notes: GENE_ASSOCIATION: (9187.1) or (25769.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10484410,PMID:10662833,PMID:11294880,PMID:12379639,PMID:14770312,PMID:9478004 NOTES:NCD
fast: false
modifier: MODEL1310110061#
kinetic law: MODEL1310110061#
reactant: MODEL1310110061#
product: MODEL1310110061#

metaM dd2coa m
initial concentration: 1.0
has only substance units: false
notes: FORMULA: C33H52N7O17P3S CHARGE: -4 INCHI: InChI=1S/C33H56N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-24(42)61-17-16-35-23(41)14-15-36-31(45)28(44)33(2,3)19-54-60(51,52)57-59(49,50)53-18-22-27(56-58(46,47)48)26(43)32(55-22)40-21-39-25-29(34)37-20-38-30(25)40/h12-13,20-22,26-28,32,43-44H,4-11,14-19H2,1-3H3,(H,35,41)(H,36,45)(H,49,50)(H,51,52)(H2,34,37,38)(H2,46,47,48)/p-4/b13-12+/t22-,26-,27-,28+,32-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01078 EHMN_ABBREVIATION: C03221
is: CHEBI:57330
is: HMDB03712
type: Species
is: SBO:0000247
constant: false
boundary condition: false
initial amount: NaN
name: trans-dodec-2-enoyl-CoA(4-)

metaR ME1m
kinetic law: MODEL1310110061#
reactant: MODEL1310110061#
fast: false
reversible: false
modifier: MODEL1310110061#
type: Reaction
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/1.1.1.38
product: MODEL1310110061#
name: malic enzyme (NAD), mitochondrial
is: SBO:0000176
notes: GENE_ASSOCIATION: (4200.1) SUBSYSTEM: Pyruvate metabolism EC Number: 1.1.1.40 Confidence Level: 0 AUTHORS: NOTES:NCD

http://identifiers.org/biomodels.db/MODEL1310110061#_d327d865_9cd6_44f2_a295_b35ea9c180a3
is: SBO:0000252
is: Q13057
initial amount: NaN
is encoded by: hsa:80347
name: COASY
initial concentration: NaN
boundary condition: true
type: Species
has only substance units: false
constant: false

metaR r0181
kinetic law: MODEL1310110061#
notes: GENE_ASSOCIATION: (AA081045.1) or (AI620219.1) or (220.1) or (219.1) or (217.1) or (218.1) or (224.1) or (221.1) or (222.1) or (501.1) or (223.1) or (AU149534.1) or (T83654.1) or (U37519.1) SUBSYSTEM: Purine catabolism EC Number: 3.6.1.5 Confidence Level: 0 AUTHORS: PMID:15652174,PMID:16752921,PMID:17095758 NOTES:
name: ITP diphosphohydrolase Purine metabolism EC:3.6.1.5
is version of: http://identifiers.org/ec-code/1.2.1.3
product: MODEL1310110061#
fast: false
is described by: ECO:0000000
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.2.1.5
reversible: true
type: Reaction
reactant: MODEL1310110061#
modifier: MODEL1310110061#

metaM focytC m
has only substance units: false
is: SBO:0000247
initial amount: NaN
notes: FORMULA: C42H54FeN8O6S2 CHARGE: 2 HEPATONET_1.0_ABBREVIATION: HC00124
is: CHEBI:16928
initial concentration: 1.0
type: Species
boundary condition: false
constant: false
name: Ferrocytochrome C

metaR GLYC3PFADm
product: MODEL1310110061#
is: SBO:0000176
type: Reaction
fast: false
name: glycerophosphate shuttle for trasnfer of reducing equivalents
notes: GENE_ASSOCIATION: SUBSYSTEM: Oxidative phosphorylation EC Number: Confidence Level: 2 AUTHORS: NOTES:
reversible: false
kinetic law: MODEL1310110061#
reactant: MODEL1310110061#
is described by: ECO:0000134

http://identifiers.org/biomodels.db/MODEL1310110061#_d6f8b389_feb0_46e3_be1a_60eac5a1d61e
type: Species
boundary condition: true
initial amount: NaN
name: HSD17B10
is encoded by: hsa:3028
initial concentration: NaN
constant: false
is: Q99714
has only substance units: false
is: SBO:0000252

metaR PE HSter
kinetic law: MODEL1310110061#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: PMID:10856717,PMID:15311932 NOTES:
is described by: ECO:0000000
reversible: true
reactant: MODEL1310110061#
is: SBO:0000185
name: phosphatidylethanolamine scramblase
product: MODEL1310110061#
type: Reaction
fast: false

http://identifiers.org/biomodels.db/MODEL1310110061#_813974f1_73c6_4d36_a554_92d0d0c88588
is: SBO:0000252
boundary condition: true
has only substance units: false
initial concentration: NaN
is encoded by: hsa:2589
is: Q10472
type: Species
constant: false
initial amount: NaN
name: GALNT1

metaR EX idp LPAREN e RPAREN
kinetic law: MODEL1310110061#
reactant: MODEL1310110061#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: IDP exchange
type: Reaction

metaR DM atp c
kinetic law: MODEL1310110061#
fast: false
type: Reaction
is described by: ECO:0000134
name: DM_atp(c)
reversible: false
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: AUTHORS: NOTES:
product: MODEL1310110061#
reactant: MODEL1310110061#

metaR FAOXC184C163m
kinetic law: MODEL1310110061#
product: MODEL1310110061#
reactant: MODEL1310110061#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation (C18:4-->C16:3)m
type: Reaction

metaM adn c
notes: FORMULA: C10H13N5O4 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00196 EHMN_ABBREVIATION: C00212
is: HMDB00050
is: SBO:0000247
constant: false
is: C00212
type: Species
boundary condition: false
name: Adenosine
is: CHEBI:16335
initial concentration: 1.0
has only substance units: false
initial amount: NaN

metaR r1973
name: Y+LAT2 Utilized transport
is described by: ECO:0000000
fast: false
reactant: MODEL1310110061#
reversible: false
type: Reaction
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
kinetic law: MODEL1310110061#
is: SBO:0000185
modifier: MODEL1310110061#
product: MODEL1310110061#

metaM HC01415 m
name: (2E)-Octenoyl-CoA
type: Species
notes: FORMULA: C29H44N7O17P3S CHARGE: -4 INCHI: InChI=1S/C29H48N7O17P3S/c1-4-5-6-7-8-9-20(38)57-13-12-31-19(37)10-11-32-27(41)24(40)29(2,3)15-50-56(47,48)53-55(45,46)49-14-18-23(52-54(42,43)44)22(39)28(51-18)36-17-35-21-25(30)33-16-34-26(21)36/h8-9,16-18,22-24,28,39-40H,4-7,10-15H2,1-3H3,(H,31,37)(H,32,41)(H,45,46)(H,47,48)(H2,30,33,34)(H2,42,43,44)/b9-8+/t18-,22-,23-,24+,28-/m1/s1 EHMN_ABBREVIATION: C05276
has only substance units: false
constant: false
is: CHEBI:27537
initial concentration: 1.0
boundary condition: false
initial amount: NaN
is: SBO:0000247

metaM cdp c
initial amount: NaN
initial concentration: 1.0
is: HMDB01546
type: Species
constant: false
is: CHEBI:58069
name: CDP
notes: FORMULA: C9H12N3O11P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00110 EHMN_ABBREVIATION: C00112
is: SBO:0000247
is: C00112
has only substance units: false
boundary condition: false

metaM tststerone e
name: testosterone
is: SBO:0000247
initial amount: NaN
notes: FORMULA: C19H28O2 CHARGE: 0 INCHI: InChI=1S/C19H28O2/c1-18-9-7-13(20)11-12(18)3-4-14-15-5-6-17(21)19(15,2)10-8-16(14)18/h11,14-17,21H,3-10H2,1-2H3/t14-,15-,16-,17-,18-,19-/m0/s1 EHMN_ABBREVIATION: C00535
is: CHEBI:17347
type: Species
initial concentration: 1.0
has only substance units: false
boundary condition: false
constant: false
is: HMDB00234

metaR r0517
is version of: http://identifiers.org/ec-code/1.17.4.1
fast: false
notes: GENE_ASSOCIATION: (BE966236.1) or (6240.1) or (6241.1) or (50484.1) SUBSYSTEM: Unassigned EC Number: 2.3.1.37 Confidence Level: 0 AUTHORS: PMID:7592562 NOTES:
reversible: true
modifier: MODEL1310110061#
is: SBO:0000176
kinetic law: MODEL1310110061#
reactant: MODEL1310110061#
is described by: ECO:0000000
type: Reaction
product: MODEL1310110061#
name: Succinyl-CoA:glycine C-succinyl-transferase(decarboxylating) EC:2.3.1.37

http://identifiers.org/biomodels.db/MODEL1310110061#_55d576c6_3e72_4e0a_9497_06b3c38a3d49
initial amount: NaN
initial concentration: NaN
constant: false
name: _U52111_1_c
type: Species
is: SBO:0000252
is encoded by: hsa:U52111
has only substance units: false
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110061#_54b381e0_8284_471e_b3a4_b2ebf9e30b82
name: ENPP1
type: Species
is: SBO:0000252
boundary condition: true
initial concentration: NaN
initial amount: NaN
is: P22413
constant: false
is encoded by: hsa:5167
has only substance units: false

metaR r0202
notes: GENE_ASSOCIATION: SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: 1.1.1.8 Confidence Level: 0 AUTHORS: PMID:17045662,PMID:7772607 NOTES:
is: SBO:0000176
reactant: MODEL1310110061#
fast: false
is described by: ECO:0000000
product: MODEL1310110061#
type: Reaction
kinetic law: MODEL1310110061#
reversible: true
name: sn-Glycerol-3-phosphate:NAD+ 2-oxidoreductase Glycerophospholipid metabolism EC:1.1.1.8

metaR RE1804M
notes: GENE_ASSOCIATION: (1593.1) SUBSYSTEM: Bile acid synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:9660774 NOTES:
modifier: MODEL1310110061#
reactant: MODEL1310110061#
kinetic law: MODEL1310110061#
is version of: http://identifiers.org/ec-code/1.14.13.15
fast: false
is: SBO:0000176
is described by: ECO:0000000
product: MODEL1310110061#
reversible: true
name: RE1804
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110061#_4c56bc8f_3d4b_4bc6_8e58_bb3ac8ed1837
is: SBO:0000252
is encoded by: hsa:3712
has only substance units: false
boundary condition: true
is: B3KVI7
initial concentration: NaN
initial amount: NaN
constant: false
type: Species
name: IVD

metaM i e
boundary condition: false
type: Species
notes: FORMULA: I CHARGE: -1 INCHI: InChI=1S/HI/h1H/p-1 EHMN_ABBREVIATION: C00708
name: iodide
is: SBO:0000247
is: HMDB12238
is: CHEBI:16382
has only substance units: false
initial amount: NaN
constant: false
initial concentration: 1.0

metaM dttp c
name: dTTP
is: C00459
notes: FORMULA: C10H13N2O14P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00368 EHMN_ABBREVIATION: C00459
type: Species
constant: false
is: SBO:0000247
boundary condition: false
initial concentration: 1.0
initial amount: NaN
has only substance units: false
is: HMDB01342
is: CHEBI:37568

metaR r0295
type: Reaction
kinetic law: MODEL1310110061#
notes: GENE_ASSOCIATION: (6576.1) SUBSYSTEM: Glycine, serine, alanine and threonine metabolism EC Number: 2.1.2.10 Confidence Level: 0 AUTHORS: PMID:7916605 NOTES:
product: MODEL1310110061#
reactant: MODEL1310110061#
fast: false
reversible: false
name: glycine synthase Nitrogen metabolism EC:2.1.2.10
is described by: ECO:0000000
is: SBO:0000176
modifier: MODEL1310110061#

metaM HC00591 c
initial concentration: 1.0
notes: FORMULA: C5H6NO4 CHARGE: -1 INCHI: InChI=1S/C5H7NO4/c6-4(8)2-1-3(7)5(9)10/h1-2H2,(H2,6,8)(H,9,10)/p-1 EHMN_ABBREVIATION: C00940
is: CHEBI:16769
type: Species
has only substance units: false
boundary condition: false
name: 2-oxoglutaramate
initial amount: NaN
is: SBO:0000247
constant: false

metaM dcyt n
initial amount: NaN
boundary condition: false
name: 2'-deoxycytidine
initial concentration: 1.0
is: CHEBI:15698
has only substance units: false
notes: FORMULA: C9H13N3O4 CHARGE: 0 INCHI: InChI=1S/C9H13N3O4/c10-7-1-2-12(9(15)11-7)8-3-5(14)6(4-13)16-8/h1-2,5-6,8,13-14H,3-4H2,(H2,10,11,15)/t5-,6+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00574 EHMN_ABBREVIATION: C00881
is: SBO:0000247
type: Species
is: HMDB00014
constant: false

metaR DADNt4
kinetic law: MODEL1310110061#
is described by: ECO:0000000
reactant: MODEL1310110061#
product: MODEL1310110061#
fast: false
type: Reaction
reversible: true
name: deoxyadenosine transport via diffusion
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10899995 NOTES:
is: SBO:0000185

metaR NMNATr
notes: GENE_ASSOCIATION: (349565.1) or (23057.1) or (23057.2) SUBSYSTEM: NAD metabolism EC Number: Confidence Level: 4 AUTHORS: NOTES:
name: nicotinamide-nucleotide adenylyltransferase
reactant: MODEL1310110061#
modifier: MODEL1310110061#
kinetic law: MODEL1310110061#
is described by: ECO:0000269
reversible: true
product: MODEL1310110061#
fast: false
is version of: http://identifiers.org/ec-code/2.7.7.1
is: SBO:0000176
type: Reaction

metaM ump r
boundary condition: false
initial concentration: 1.0
initial amount: NaN
is: CHEBI:57865
is: HMDB00288
has only substance units: false
type: Species
is: SBO:0000247
name: UMP
constant: false
notes: FORMULA: C9H11N2O9P CHARGE: -2 INCHI: InChI=1S/C9H13N2O9P/c12-5-1-2-11(9(15)10-5)8-7(14)6(13)4(20-8)3-19-21(16,17)18/h1-2,4,6-8,13-14H,3H2,(H,10,12,15)(H2,16,17,18)/p-2/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00105 EHMN_ABBREVIATION: C00105

http://identifiers.org/biomodels.db/MODEL1310110061#_56faba97_5960_4d97_ae21_9dcbaf478ace
initial amount: NaN
initial concentration: NaN
name: CA14
has only substance units: false
boundary condition: true
is: A8K3J4
is encoded by: hsa:23632
is: SBO:0000252
type: Species
constant: false

metaR THYMDtm
is described by: ECO:0000269
product: MODEL1310110061#
modifier: MODEL1310110061#
fast: false
name: thymd transport
reversible: true
kinetic law: MODEL1310110061#
reactant: MODEL1310110061#
notes: GENE_ASSOCIATION: (2030.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:10722669,PMID:12838422,PMID:14607828 NOTES:TDV
is: SBO:0000185
type: Reaction

metaR r0580
is: SBO:0000176
modifier: MODEL1310110061#
kinetic law: MODEL1310110061#
is version of: http://identifiers.org/ec-code/1.3.99.7
product: MODEL1310110061#
is described by: ECO:0000000
fast: false
reversible: true
reactant: MODEL1310110061#
name: N-((R)-Pantothenoyl)-L-cysteine carboxy-lyase Pantothenate and CoA biosynthesis EC:4.1.1.30
type: Reaction
notes: GENE_ASSOCIATION: (AD000092.1) or (2639.1) SUBSYSTEM: CoA synthesis EC Number: 4.1.1.30 Confidence Level: 0 AUTHORS: PMID:13163064 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110061#_47c4fe55_f323_4090_8a8e_089424d632a5
initial amount: NaN
has only substance units: false
constant: false
boundary condition: true
name: PIK3C2B
initial concentration: NaN
is encoded by: hsa:5287
is: O00750
is: SBO:0000252
type: Species

metaR EX gchola LPAREN e RPAREN
kinetic law: MODEL1310110061#
reactant: MODEL1310110061#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Glycocholate exchange
type: Reaction

metaM thexddcoa m
constant: false
name: trans7,10-hexadecadienoylcoa
initial concentration: 1.0
is: SBO:0000247
boundary condition: false
has only substance units: false
is: HMDB02288
notes: FORMULA: C37H58N7O17P3S CHARGE: -4
type: Species
initial amount: NaN

metaR NACHEX27ly
product: MODEL1310110061#
is described by: ECO:0000269
is: SBO:0000176
name: beta-N-acetylhexosaminidase, lysosomal
notes: GENE_ASSOCIATION: (3073.1 and 3074.1) or (3073.1) or (3074.1) SUBSYSTEM: Hyaluronan metabolism EC Number: 3.2.1.52 Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12562784 NOTES:NCD
reactant: MODEL1310110061#
modifier: MODEL1310110061#
kinetic law: MODEL1310110061#
type: Reaction
fast: false
reversible: false
is version of: http://identifiers.org/ec-code/3.2.1.52

http://identifiers.org/biomodels.db/MODEL1310110061#_11dd0ab7_36ca_44e8_90ea_533a0e0b8291
is encoded by: hsa:NM 013421
type: Species
name: _NM_013421_1_m
initial concentration: NaN
has only substance units: false
is: SBO:0000252
boundary condition: true
constant: false
initial amount: NaN

metaM ha pre1 l
type: Species
initial amount: NaN
initial concentration: 1.0
notes: FORMULA: C14H20NO11 CHARGE: -1 INCHI: InChI=1S/C14H21NO11/c1-4(17)15-8-11(10(20)7(3-16)24-13(8)23)26-14-9(19)5(18)2-6(25-14)12(21)22/h2,5,7-11,13-14,16,18-20,23H,3H2,1H3,(H,15,17)(H,21,22)/t5-,7+,8+,9+,10+,11+,13+,14-/m0/s1
name: hyaluronan biosynthesis, precursor 1
boundary condition: false
has only substance units: false
is: CHEBI:16126
is: SBO:0000247
constant: false

metaR 1PPDCRp
name: delta1-piperideine-2-carboxylate reductase, perixosomal
product: MODEL1310110061#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Lysine metabolism EC Number: Confidence Level: 2 AUTHORS: PMID:10485319,PMID:10772957 NOTES:MM
type: Reaction
kinetic law: MODEL1310110061#
reactant: MODEL1310110061#
is: SBO:0000176
fast: false
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110061#_09979ab7_78e0_4a68_bdee_f061fa9ec13d
initial amount: NaN
has only substance units: false
boundary condition: true
initial concentration: NaN
constant: false
type: Species
is encoded by: hsa:5295
name: PIK3CD:PIK3R1
is: SBO:0000297
has part: E7EX19

metaM accoa m
is: SBO:0000247
constant: false
is: CHEBI:57288
name: Acetyl-CoA
has only substance units: false
is: C00024
is: HMDB01206
initial amount: NaN
notes: FORMULA: C23H34N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00033 EHMN_ABBREVIATION: C00024
boundary condition: false
type: Species
initial concentration: 1.0

metaM 3aib D c
is: HMDB02299
type: Species
has only substance units: false
name: D-3-Amino-isobutanoate
initial concentration: 1.0
is: C03265
boundary condition: false
notes: FORMULA: C4H9NO2 CHARGE: 0 INCHI: InChI=1/C4H9NO2/c1-3(2-5)4(6)7/h3H,2,5H2,1H3,(H,6,7)/t3-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00715
is: SBO:0000247
constant: false
initial amount: NaN

metaM CE4872 m
boundary condition: false
initial concentration: 1.0
notes: FORMULA: C27H46O4 CHARGE: 0 INCHI: InChI=1/C27H46O4/c1-16(15-28)6-5-7-17(2)20-8-9-21-25-22(14-24(31)27(20,21)4)26(3)11-10-19(29)12-18(26)13-23(25)30/h15-25,29-31H,5-14H2,1-4H3/t16u,17-,18-,19+,20-,21-,22-,23+,24-,25-,26?,27-/m1/s1 EHMN_ABBREVIATION: CE4872
is: SBO:0000247
type: Species
name: 3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-27-al
has only substance units: false
initial amount: NaN
is: HMDB00127
is: CHEBI:15748
constant: false

http://identifiers.org/biomodels.db/MODEL1310110061#_0548f411_8a9a_4e99_b75c_08190dda6bf3
has only substance units: false
name: _AA664770_1_m
boundary condition: true
is: SBO:0000252
constant: false
initial concentration: NaN
is encoded by: hsa:AA664770
type: Species
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110061#_7cb31d07_b217_42bf_8760_2d3617f379c7
boundary condition: true
constant: false
initial concentration: NaN
is: G3XA95
initial amount: NaN
type: Species
is encoded by: hsa:8611
name: PPAP2A
has only substance units: false
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110061#_087ed8eb_0725_45d6_808e_b5904c39da00
is encoded by: hsa:1891
is: SBO:0000252
is: Q13011
has only substance units: false
initial concentration: NaN
type: Species
constant: false
name: ECH1
boundary condition: true
initial amount: NaN

metaM ser D e
initial concentration: 1.0
boundary condition: false
constant: false
has only substance units: false
name: D-serine
type: Species
notes: FORMULA: C3H7NO3 CHARGE: 0 INCHI: InChI=1S/C3H7NO3/c4-2(1-5)3(6)7/h2,5H,1,4H2,(H,6,7)/t2-/m1/s1
initial amount: NaN
is: SBO:0000247
is: CHEBI:16523
is: HMDB03406

metaR DSREDUCr
type: Reaction
reversible: false
notes: GENE_ASSOCIATION: (1718.1) SUBSYSTEM: Squalene and cholesterol synthesis EC Number: Confidence Level: 4 AUTHORS: Davidson, N. O., Magun, A. M. and Glickman, R. M. 2011. Enterocyte Lipid Absorption and Secretion. Comprehensive Physiology. 505?526, PMID: 17015489, PMID: 18216769, PMID: 6833883, PMID: 11229876. NOTES:Enterocytes stand next to liver in endogenous cholesterol synthesis. in rats they provide 25% of bodys cholesterol. the crypt epithelial cells synthesize maximum cholesterol when compared to other parts of the GI tract (PMCID: PMC292609). Reactions till farnesyl pyrophosphate operates in cytosol, however, further steps including squalene synthase operates in E.R (Harpers illustrated Biochemistry (2009) 28th edition, Lange medical publications, chapter 26, page 224-227). all the cholesterol synthesis enzymes have also been found in peroxisomes (PMID: 12121718), no evidence for enterocyte sub-cellular sites, so cytosolic reactions have been added according to Harper book.
is version of: http://identifiers.org/ec-code/1.3.1.72
modifier: MODEL1310110061#
reactant: MODEL1310110061#
name: Desmosterol reductase
kinetic law: MODEL1310110061#
fast: false
is: SBO:0000176
product: MODEL1310110061#
is described by: ECO:0000134

metaR DURIt
product: MODEL1310110061#
type: Reaction
is: SBO:0000185
name: deoxyuridine transport via diffusion
reversible: true
fast: false
reactant: MODEL1310110061#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10899995 NOTES:
kinetic law: MODEL1310110061#
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110061#_40f0afd6_87e4_42c3_9229_39e89278cd0b
is encoded by: hsa:4713
has only substance units: false
name: NDUFB7
initial concentration: NaN
is: P17568
is: SBO:0000252
boundary condition: true
constant: false
initial amount: NaN
type: Species

metaR KDNH
notes: GENE_ASSOCIATION: SUBSYSTEM: Aminosugar metabolism EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD
kinetic law: MODEL1310110061#
name: 2-keto-3deoxy-D-glycero-D-galactononic acid phosphohydrolase
fast: false
product: MODEL1310110061#
is described by: ECO:0000000
type: Reaction
reversible: false
reactant: MODEL1310110061#
is: SBO:0000176

metaR ACACT1x
modifier: MODEL1310110061#
kinetic law: MODEL1310110061#
product: MODEL1310110061#
type: Reaction
is version of: http://identifiers.org/ec-code/2.3.1.9
reactant: MODEL1310110061#
is: SBO:0000176
name: acetyl-CoA C-acetyltransferase, mitochondrial
reversible: false
notes: GENE_ASSOCIATION: (39.1) SUBSYSTEM: Cholesterol metabolism EC Number: 2.3.1.9 Confidence Level: 4 AUTHORS: PMID:11108725 NOTES:NCD NJ - added peroxisomal version
fast: false
is described by: ECO:0000134

metaM ametam c
notes: FORMULA: C14H24N6O3S CHARGE: 2 HEPATONET_1.0_ABBREVIATION: HC00683 EHMN_ABBREVIATION: C01137
initial concentration: 1.0
type: Species
is: CHEBI:57443
name: S-Adenosylmethioninamine
initial amount: NaN
has only substance units: false
is: C01137
is: HMDB00988
constant: false
boundary condition: false
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110061#_50d4c8d1_2ae1_4857_818e_a14d6a6790a1
is: Q9NNW7
name: TXNRD2
initial amount: NaN
is: SBO:0000252
is encoded by: hsa:10587
type: Species
initial concentration: NaN
constant: false
has only substance units: false
boundary condition: true

metaR PACCOAL
fast: false
product: MODEL1310110061#
type: Reaction
reversible: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Phenylalanine metabolism EC Number: 6.2.1.30 Confidence Level: 2 AUTHORS: NOTES:JLR
reactant: MODEL1310110061#
kinetic law: MODEL1310110061#
is described by: ECO:0000000
is: SBO:0000176
name: phenylacetate-CoA ligase

http://identifiers.org/biomodels.db/MODEL1310110061#_59e74ef0_be7d_4b4b_bef2_52f85238ca28
is encoded by: hsa:55586
is: SBO:0000252
name: MIOX
initial concentration: NaN
is: Q9UGB7
boundary condition: true
type: Species
has only substance units: false
constant: false
initial amount: NaN

metaM ppcoa x
is: HMDB01275
is: CHEBI:57392
has only substance units: false
notes: FORMULA: C24H36N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00101 EHMN_ABBREVIATION: C00100
initial amount: NaN
constant: false
boundary condition: false
is: SBO:0000247
initial concentration: 1.0
is: C00100
name: Propanoyl-CoA
type: Species

http://identifiers.org/biomodels.db/MODEL1310110061#_69a149d8_738c_43dc_a1c1_e07d36c6ab89
is encoded by: hsa:7359
initial concentration: NaN
name: _7359_1_c
constant: false
boundary condition: true
initial amount: NaN
has only substance units: false
type: Species
is: SBO:0000252

metaR DURItn
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: NOTES:IT
is described by: ECO:0000000
reversible: true
product: MODEL1310110061#
reactant: MODEL1310110061#
fast: false
kinetic law: MODEL1310110061#
name: deoxyuridine transport in nucleus
type: Reaction

metaM CE5162 r
has only substance units: false
is: CHEBI:57460
name: trans,cis-2,9-octadecadienoyl-CoA
boundary condition: false
initial concentration: 1.0
constant: false
initial amount: NaN
is: HMDB01509
is: SBO:0000247
type: Species
notes: FORMULA: C39H62N7O17P3S CHARGE: -4 INCHI: InChI=1/C39H66N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-30(48)67-23-22-41-29(47)20-21-42-37(51)34(50)39(2,3)25-60-66(57,58)63-65(55,56)59-24-28-33(62-64(52,53)54)32(49)38(61-28)46-27-45-31-35(40)43-26-44-36(31)46/h11-12,18-19,26-28,32-34,38,49-50H,4-10,13-17,20-25H2,1-3H3,(H,41,47)(H,42,51)(H,55,56)(H,57,58)(H2,40,43,44)(H2,52,53,54)/p-4/b12-11-,19-18+/t28-,32+,33+,34u,38-/m0/s1 EHMN_ABBREVIATION: CE5162

metaR PPItr
kinetic law: MODEL1310110061#
type: Reaction
reactant: MODEL1310110061#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: NOTES:diffusion NJ
is: SBO:0000185
is described by: ECO:0000000
product: MODEL1310110061#
fast: false
reversible: true
name: Diphosphate transporter, endoplasmic reticulum

metaM Tn antigen l
constant: false
is: SBO:0000247
notes: FORMULA: C8H14NO5X CHARGE: 0
has only substance units: false
name: Tn antigen
type: Species
is: C04383
initial concentration: 1.0
initial amount: NaN
boundary condition: false

metaR PGSr
name: Prostaglandin G/H synthase
kinetic law: MODEL1310110061#
modifier: MODEL1310110061#
is: SBO:0000176
fast: false
type: Reaction
product: MODEL1310110061#
notes: GENE_ASSOCIATION: (5743.1) or (5742.1) SUBSYSTEM: Eicosanoid metabolism EC Number: 1.14.99.1 Confidence Level: 4 AUTHORS: PMID:14511332,PMID:1907252 NOTES:NJ
is version of: http://identifiers.org/ec-code/1.14.99.1
reversible: false
reactant: MODEL1310110061#
is described by: ECO:0000269

metaM tethex3coa c
initial concentration: 1.0
boundary condition: false
is: C16168
is: SBO:0000247
is: http://identifiers.org/pubchem.compound/47205478
type: Species
is: HMDB06243
initial amount: NaN
has only substance units: false
notes: FORMULA: C45H66N7O17P3S CHARGE: -4 INCHI: InChI=1/C45H70N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-24-25-36(54)73-29-28-47-35(53)26-27-48-43(57)40(56)45(2,3)31-66-72(63,64)69-71(61,62)65-30-34-39(68-70(58,59)60)38(55)44(67-34)52-33-51-37-41(46)49-32-50-42(37)52/h5-6,8-9,11-12,14-15,17-18,20-21,32-34,38-40,44,55-56H,4,7,10,13,16,19,22-31H2,1-3H3,(H,47,53)(H,48,57)(H,61,62)(H,63,64)(H2,46,49,50)(H2,58,59,60)/b6-5-,9-8-,12-11-,15-14-,18-17-,21-20-/t34-,38?,39-,40+,44-/m1/s1
constant: false
name: tetracosahexaenoyl coenzyme A

metaR r0208
modifier: MODEL1310110061#
is version of: http://identifiers.org/ec-code/4.4.1.1
name: GTP:alpha-D-mannose-1-phosphate guanylyltransferase Fructose and mannose metabolism EC:2.7.7.13
notes: GENE_ASSOCIATION: (1491.1) SUBSYSTEM: Fructose and mannose metabolism EC Number: 2.7.7.13 Confidence Level: 0 AUTHORS: PMID:10025667,PMID:8549746,PMID:9451026 NOTES:
product: MODEL1310110061#
kinetic law: MODEL1310110061#
reactant: MODEL1310110061#
is: SBO:0000176
reversible: true
is described by: ECO:0000000
type: Reaction
fast: false

metaR FACOAL140i
is: SBO:0000176
modifier: MODEL1310110061#
name: fatty-acid--CoA ligase (tetradecanoate)
kinetic law: MODEL1310110061#
reactant: MODEL1310110061#
type: Reaction
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (2181.1) SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 4 AUTHORS: NOTES:JLR
product: MODEL1310110061#
reversible: false
fast: false
is version of: http://identifiers.org/ec-code/6.2.1.3

metaR PSERT
notes: GENE_ASSOCIATION: (29968.1) or (29968.2) SUBSYSTEM: Glycine, serine, alanine and threonine metabolism EC Number: 2.6.1.52 Confidence Level: 4 AUTHORS: PMID:12633500 NOTES:
is: SBO:0000176
type: Reaction
fast: false
reactant: MODEL1310110061#
reversible: false
product: MODEL1310110061#
kinetic law: MODEL1310110061#
name: phosphoserine transaminase
is described by: ECO:0000269
modifier: MODEL1310110061#
is version of: http://identifiers.org/ec-code/2.6.1.52

metaR EX leuktrB4 LPAREN e RPAREN
kinetic law: MODEL1310110061#
reactant: MODEL1310110061#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: leukotriene B4 exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110061#_d9f104d4_8d2b_48cc_97fc_2ff926d1cb1e
is: O15244
is: SBO:0000252
initial concentration: NaN
is encoded by: hsa:6582
boundary condition: true
has only substance units: false
type: Species
name: SLC22A2
constant: false
initial amount: NaN

metaR r0739
reversible: true
kinetic law: MODEL1310110061#
fast: false
is: SBO:0000176
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (2194.1) SUBSYSTEM: Bile acid synthesis EC Number: 1.1.1.1 Confidence Level: 0 AUTHORS: PMID:5487878,PMID:6338006,PMID:6379302 NOTES:
type: Reaction
name: alcohol dehydrogenase Bile acid biosynthesis EC:1.1.1.1
is version of: http://identifiers.org/ec-code/2.3.1.85
reactant: MODEL1310110061#
product: MODEL1310110061#
modifier: MODEL1310110061#

metaR r0587
reversible: true
fast: false
type: Reaction
product: MODEL1310110061#
modifier: MODEL1310110061#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (220.1) or (218.1) or (221.1) or (222.1) or (U37519.1) SUBSYSTEM: Unassigned EC Number: 3.1.3.41 Confidence Level: 0 AUTHORS: PMID:11797369,PMID:1730777,PMID:388794 NOTES:
name: 4-Nitrophenyl phosphate phosphohydrolase gamma-Hexachlorocyclohexane degradation EC:3.1.3.2 EC:3.1.3.41 EC:3.1.3.1
kinetic law: MODEL1310110061#
is version of: http://identifiers.org/ec-code/1.2.1.5
reactant: MODEL1310110061#
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110061#_ae747b06_2836_45f0_939a_8d533f486719
initial amount: NaN
name: _AD000092_1_c
is encoded by: hsa:AD000092
has only substance units: false
boundary condition: true
constant: false
is: SBO:0000252
type: Species
initial concentration: NaN

metaM ksii core2 deg2 l
is: HMDB00143
is: CHEBI:12936
has only substance units: false
notes: FORMULA: C70H114N5O56S2X CHARGE: -2
type: Species
initial amount: NaN
is: SBO:0000247
initial concentration: 1.0
boundary condition: false
constant: false
name: keratan sulfate II (core 2-linked), degradation product 2

metaR RE0944E
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/3.2.1.17
name: RE0944
is: SBO:0000176
reactant: MODEL1310110061#
kinetic law: MODEL1310110061#
notes: GENE_ASSOCIATION: (276.1) or (277.1) or (278.1) or (279.1) or (276.1) or (277.1) or (278.1) or (279.1) or (280.1) or (84569.1) SUBSYSTEM: Starch and sucrose metabolism EC Number: 3.2.1.1 Confidence Level: 0 AUTHORS: PMID:385176,PMID:8528071,PMID:890964 NOTES:
type: Reaction
is version of: http://identifiers.org/ec-code/3.2.1.1
modifier: MODEL1310110061#
product: MODEL1310110061#
fast: false
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110061#_bb3ef2b7_68bb_45ca_a3a0_3a7462d44106
initial amount: NaN
type: Species
boundary condition: true
constant: false
initial concentration: NaN
is encoded by: hsa:AA021081
name: _AA021081_1_r
has only substance units: false
is: SBO:0000252

metaM ser D c
is: CHEBI:16523
initial amount: NaN
has only substance units: false
name: D-serine
constant: false
notes: FORMULA: C3H7NO3 CHARGE: 0 INCHI: InChI=1S/C3H7NO3/c4-2(1-5)3(6)7/h2,5H,1,4H2,(H,6,7)/t2-/m1/s1
initial concentration: 1.0
type: Species
boundary condition: false
is: SBO:0000247
is: HMDB03406

metaR AKR1D2
modifier: MODEL1310110061#
is version of: http://identifiers.org/ec-code/1.3.1.3
is described by: ECO:0000269
is: SBO:0000176
kinetic law: MODEL1310110061#
reactant: MODEL1310110061#
type: Reaction
reversible: false
fast: false
product: MODEL1310110061#
name: aldo-keto reductase family 1, member D1 (delta 4-3-ketosteroid-5-beta-reductase)
notes: GENE_ASSOCIATION: (6718.1) SUBSYSTEM: Bile acid synthesis EC Number: 1.3.99.6 Confidence Level: 4 AUTHORS: NOTES:refs: uniprot, KEGG DW Russell bile acid synthesis review paper (see human recon journal citations) NJ

metaR BILGLCURtr
kinetic law: MODEL1310110061#
fast: false
name: glucuronidated compound transport
reversible: true
reactant: MODEL1310110061#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: NOTES:unknown mechanism, however glucuronidated metabolites need to get out of the cell NJ
product: MODEL1310110061#
type: Reaction
is described by: ECO:0000000

metaM imp c
is: SBO:0000247
is: HMDB00175
constant: false
name: IMP
initial concentration: 1.0
notes: FORMULA: C10H11N4O8P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00128 EHMN_ABBREVIATION: C00130
is: CHEBI:58053
boundary condition: false
has only substance units: false
type: Species
is: C00130
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110061#_07fbebc4_b335_4627_be1e_80e5afdda00d
is: SBO:0000252
constant: false
name: SLC25A20
has only substance units: false
initial concentration: NaN
initial amount: NaN
is: O43772
type: Species
boundary condition: true
is encoded by: hsa:788

http://identifiers.org/biomodels.db/MODEL1310110061#_3ba170eb_7ade_4412_a7a5_ee35fccfa330
initial amount: NaN
is encoded by: hsa:2686
name: GGT7
constant: false
type: Species
is: SBO:0000252
has only substance units: false
is: A0PJJ9
initial concentration: NaN
boundary condition: true

metaR r0917
reactant: MODEL1310110061#
type: Reaction
is described by: ECO:0000000
reversible: true
is: SBO:0000185
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
product: MODEL1310110061#
fast: false
kinetic law: MODEL1310110061#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172 NOTES:

metaM arg L m
notes: FORMULA: C6H15N4O2 CHARGE: 1 INCHI: InChI=1S/C6H14N4O2/c7-4(5(11)12)2-1-3-10-6(8)9/h4H,1-3,7H2,(H,11,12)(H4,8,9,10)/p+1/t4-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00065
constant: false
is: SBO:0000247
is: HMDB00517
name: L-argininium(1+)
boundary condition: false
initial concentration: 1.0
initial amount: NaN
has only substance units: false
type: Species
is: CHEBI:32682

metaM 3aib D e
constant: false
type: Species
is: SBO:0000247
boundary condition: false
is: C03265
initial concentration: 1.0
initial amount: NaN
has only substance units: false
notes: FORMULA: C4H9NO2 CHARGE: 0 INCHI: InChI=1/C4H9NO2/c1-3(2-5)4(6)7/h3H,2,5H2,1H3,(H,6,7)/t3-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00715
is: HMDB02299
name: D-3-Amino-isobutanoate

http://identifiers.org/biomodels.db/MODEL1310110061#_3240656a_e091_4f18_8261_278c8a5bd421
is: P11168
is encoded by: hsa:6514
is: SBO:0000252
name: SLC2A2
boundary condition: true
constant: false
initial concentration: NaN
type: Species
has only substance units: false
initial amount: NaN

metaM 2dr1p c
is: HMDB01351
type: Species
boundary condition: false
initial concentration: 1.0
initial amount: NaN
notes: FORMULA: C5H9O7P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00489 EHMN_ABBREVIATION: C00672
is: CHEBI:58576
is: SBO:0000247
is: C00672
name: 2-Deoxy-D-ribose 1-phosphate
has only substance units: false
constant: false

http://identifiers.org/biomodels.db/MODEL1310110061#_defe6700_0ba0_4466_bce0_0db60996a612
constant: false
boundary condition: true
initial amount: NaN
is: Q02218
name: OGDH
is encoded by: hsa:4967
initial concentration: NaN
type: Species
has only substance units: false
is: SBO:0000252

metaM mthgxl c
is: CHEBI:17158
type: Species
notes: FORMULA: C3H4O2 CHARGE: 0 INCHI: InChI=1S/C3H4O2/c1-3(5)2-4/h2H,1H3 HEPATONET_1.0_ABBREVIATION: HC00425 EHMN_ABBREVIATION: C00546
is: HMDB01167
constant: false
initial concentration: 1.0
boundary condition: false
initial amount: NaN
name: methylglyoxal
has only substance units: false
is: SBO:0000247

metaR r0584
name: Deamino-NAD+ nucleotidohydrolase Nicotinate and nicotinamide metabolism EC:3.6.1.9
reversible: true
fast: false
kinetic law: MODEL1310110061#
is version of: http://identifiers.org/ec-code/1.2.1.5
product: MODEL1310110061#
type: Reaction
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (220.1) or (218.1) or (221.1) or (222.1) or (U37519.1) SUBSYSTEM: NAD metabolism EC Number: 3.6.1.9 Confidence Level: 0 AUTHORS: PMID:11579996,PMID:11946484 NOTES:
reactant: MODEL1310110061#
modifier: MODEL1310110061#
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110061#_8cc0ae76_732d_4132_95f1_89d83fb3b9f8
has only substance units: false
is: Q8TBG4
name: AGXT2L1
type: Species
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:64850
initial amount: NaN
boundary condition: true
constant: false

http://identifiers.org/biomodels.db/MODEL1310110061#_99c9caad_e58a_4d36_956b_ed23472ce609
is encoded by: hsa:4017
name: LOXL2
is: Q9Y4K0
is: SBO:0000252
boundary condition: true
initial concentration: NaN
initial amount: NaN
type: Species
constant: false
has only substance units: false

metaR EX lac L LPAREN e RPAREN
kinetic law: MODEL1310110061#
reactant: MODEL1310110061#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: L-Lactate exchange
type: Reaction

metaM ump n
is: SBO:0000247
is: CHEBI:57865
boundary condition: false
type: Species
is: HMDB00288
has only substance units: false
name: UMP(2-)
constant: false
initial amount: NaN
initial concentration: 1.0
notes: FORMULA: C9H11N2O9P CHARGE: -2 INCHI: InChI=1S/C9H13N2O9P/c12-5-1-2-11(9(15)10-5)8-7(14)6(13)4(20-8)3-19-21(16,17)18/h1-2,4,6-8,13-14H,3H2,(H,10,12,15)(H2,16,17,18)/p-2/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00105 EHMN_ABBREVIATION: C00105

metaM ha deg1 l
notes: FORMULA: C22H33N2O16 CHARGE: -1
boundary condition: false
is: CHEBI:16336
type: Species
initial amount: NaN
initial concentration: 1.0
is: SBO:0000247
has only substance units: false
name: hyaluronan degradation product 1
constant: false

http://identifiers.org/biomodels.db/MODEL1310110061#_b952495c_e88d_4377_9677_79723d3fb901
initial concentration: NaN
has only substance units: false
boundary condition: true
initial amount: NaN
constant: false
is: P14672
type: Species
name: SLC2A4
is: SBO:0000252
is encoded by: hsa:6517

metaR HPACtr
is described by: ECO:0000000
name: hydroxyphenylacetate transport via diffusion
kinetic law: MODEL1310110061#
type: Reaction
is: SBO:0000185
reactant: MODEL1310110061#
fast: false
product: MODEL1310110061#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:3753983 NOTES:SAB
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110061#_f20b2341_dcd4_4919_8e90_5807a0f9ff42
is: SBO:0000252
type: Species
constant: false
is: Q9H008
has only substance units: false
name: LHPP
boundary condition: true
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:64077

metaR r0512
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (BE966236.1) or (6240.1) or (6241.1) or (50484.1) SUBSYSTEM: Folate metabolism EC Number: 1.5.1.3 Confidence Level: 0 AUTHORS: PMID:15153070,PMID:1631094,PMID:6882460 NOTES:
type: Reaction
product: MODEL1310110061#
modifier: MODEL1310110061#
fast: false
name: Dihydrofolate:NAD+ oxidoreductase Folate biosynthesis EC:1.5.1.3
is version of: http://identifiers.org/ec-code/1.17.4.1
kinetic law: MODEL1310110061#
is: SBO:0000176
reversible: true
reactant: MODEL1310110061#

http://identifiers.org/biomodels.db/MODEL1310110061#_a5f0114f_64e9_4f56_a227_419aa3f8a603
type: Species
has only substance units: false
initial amount: NaN
is: SBO:0000252
is: Q542Y6
name: PLA2G12A
boundary condition: true
initial concentration: NaN
is encoded by: hsa:81579
constant: false

metaR ORNt3m
is described by: ECO:0000269
name: ornithine mitochondrial transport via proton antiport
reversible: true
notes: GENE_ASSOCIATION: (83884.1) or (10166.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172 NOTES:NCD
is: SBO:0000185
modifier: MODEL1310110061#
reactant: MODEL1310110061#
kinetic law: MODEL1310110061#
type: Reaction
fast: false
product: MODEL1310110061#

metaM srtn e
name: serotonin(1+)
initial concentration: 1.0
constant: false
is: CHEBI:350546
is: SBO:0000247
is: HMDB00259
initial amount: NaN
type: Species
has only substance units: false
notes: FORMULA: C10H13N2O CHARGE: 1 INCHI: InChI=1S/C10H12N2O/c11-4-3-7-6-12-10-2-1-8(13)5-9(7)10/h1-2,5-6,12-13H,3-4,11H2/p+1 HEPATONET_1.0_ABBREVIATION: HC00533 EHMN_ABBREVIATION: C00780
boundary condition: false

metaR EX dhf LPAREN e RPAREN
kinetic law: MODEL1310110061#
reactant: MODEL1310110061#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 7,8-Dihydrofolate exchange
type: Reaction

metaR NADtru
product: MODEL1310110061#
kinetic law: MODEL1310110061#
reactant: MODEL1310110061#
name: NAD transporter, endoplasmic reticulum
reversible: false
is described by: ECO:0000000
is: SBO:0000185
fast: false
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: NOTES:diffusion - but unidirectional output from ER (to avoid loops w/ NAD/NADP) NJ

metaM pail hs n
type: Species
boundary condition: false
initial concentration: 1.0
constant: false
notes: FORMULA: C9H16O9PFULLRCO2FULLR2CO2 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC02009 EHMN_ABBREVIATION: C01194
name: 1-phosphatidyl-1D-myo-inositol(1-)
has only substance units: false
initial amount: NaN
is: CHEBI:57880
is: SBO:0000247

metaM core6 l
type: Species
initial amount: NaN
is: SBO:0000247
name: Core 6
constant: false
has only substance units: false
is: HMDB00143
initial concentration: 1.0
boundary condition: false
notes: FORMULA: C16H27N2O10X CHARGE: 0
is: CHEBI:12936

metaM zymstnl r
type: Species
has only substance units: false
constant: false
initial concentration: 1.0
is: SBO:0000247
boundary condition: false
notes: FORMULA: C27H46O CHARGE: 0 INCHI: InChI=1S/C27H46O/c1-18(2)7-6-8-19(3)23-11-12-24-22-10-9-20-17-21(28)13-15-26(20,4)25(22)14-16-27(23,24)5/h18-21,23-24,28H,6-17H2,1-5H3/t19-,20+,21+,23-,24+,26+,27-/m1/s1 EHMN_ABBREVIATION: C03845
is: CHEBI:16608
name: 5alpha-cholest-8-en-3beta-ol
is: HMDB06841
initial amount: NaN

metaM prpncoa m
initial concentration: 1.0
type: Species
boundary condition: false
name: acryloyl-CoA(4-)
has only substance units: false
notes: FORMULA: C24H34N7O17P3S CHARGE: -4 INCHI: InChI=1S/C24H38N7O17P3S/c1-4-15(33)52-8-7-26-14(32)5-6-27-22(36)19(35)24(2,3)10-45-51(42,43)48-50(40,41)44-9-13-18(47-49(37,38)39)17(34)23(46-13)31-12-30-16-20(25)28-11-29-21(16)31/h4,11-13,17-19,23,34-35H,1,5-10H2,2-3H3,(H,26,32)(H,27,36)(H,40,41)(H,42,43)(H2,25,28,29)(H2,37,38,39)/p-4/t13-,17-,18-,19+,23-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00579 EHMN_ABBREVIATION: C00894
is: CHEBI:57367
is: HMDB02307
is: SBO:0000247
initial amount: NaN
constant: false

http://identifiers.org/biomodels.db/MODEL1310110061#_d001f903_dd86_4f20_ab42_118c35115402
initial amount: NaN
name: FOLR1
constant: false
is encoded by: hsa:2348
has only substance units: false
initial concentration: NaN
type: Species
boundary condition: true
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110061#_201e3641_e495_4889_acbe_e9bdcd52863c
boundary condition: true
type: Species
has only substance units: false
name: SLCO3A1
initial concentration: NaN
is encoded by: hsa:28232
initial amount: NaN
is: SBO:0000252
constant: false
is: Q9UIG8

http://identifiers.org/biomodels.db/MODEL1310110061#_465c1024_0007_4d71_b868_f46da521b758
is: P49585
is encoded by: hsa:5130
boundary condition: true
has only substance units: false
name: PCYT1A
is: SBO:0000252
initial amount: NaN
type: Species
constant: false
initial concentration: NaN

metaR SERGLNNaEx
is: SBO:0000185
name: L-serine/L-glutamine Na-dependent exchange (Ser-L in)
modifier: MODEL1310110061#
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (6510.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14530974 NOTES:SAB see Kanai and Hediger 2004 (2003), PMID 14530974
fast: false
reversible: false
kinetic law: MODEL1310110061#
product: MODEL1310110061#
reactant: MODEL1310110061#
type: Reaction

metaR NAGA2ly
name: N-acetylgalactosaminidase, alpha-
notes: GENE_ASSOCIATION: (4668.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.49 Confidence Level: 4 AUTHORS: PMID:2174888,PMID:2551294 NOTES:Alpha-galactosidase B NJ
product: MODEL1310110061#
is version of: http://identifiers.org/ec-code/3.2.1.49
modifier: MODEL1310110061#
fast: false
type: Reaction
is described by: ECO:0000000
is: SBO:0000176
reactant: MODEL1310110061#
reversible: false
kinetic law: MODEL1310110061#

metaR SERCYSNaEx
reversible: false
is described by: ECO:0000269
reactant: MODEL1310110061#
name: L-serine/L-cysteine Na-dependent exchange (Ser-L in)
modifier: MODEL1310110061#
kinetic law: MODEL1310110061#
product: MODEL1310110061#
is: SBO:0000185
type: Reaction
fast: false
notes: GENE_ASSOCIATION: (6509.1) or (6510.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14530974 NOTES:SAB see Kanai and Hediger 2004 (2003), PMID 14530974

http://identifiers.org/biomodels.db/MODEL1310110061#_e0216a54_035c_4946_95e3_3c84f7cbfa07
is encoded by: hsa:2590
type: Species
initial concentration: NaN
constant: false
boundary condition: true
is: Q10471
name: GALNT2
has only substance units: false
is: SBO:0000252
initial amount: NaN

metaR r1554
product: MODEL1310110061#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reversible: true
is: SBO:0000185
kinetic law: MODEL1310110061#
is described by: ECO:0000000
reactant: MODEL1310110061#
type: Reaction
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1

metaR DSAT
product: MODEL1310110061#
kinetic law: MODEL1310110061#
is described by: ECO:0000000
reversible: false
name: dihydrosphingosine N-acyltransferase
fast: false
type: Reaction
reactant: MODEL1310110061#
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Sphingolipid metabolism EC Number: Confidence Level: 2 AUTHORS: NOTES:CoA transfer not explicitly in rxn (accounted for in Rtotal rxn -> ARTF) NJ

http://identifiers.org/biomodels.db/MODEL1310110061#_97b4d27e_46e4_4bd6_999c_c35f440fa820
type: Species
initial concentration: NaN
is: SBO:0000252
has only substance units: false
initial amount: NaN
boundary condition: true
is encoded by: hsa:5315
constant: false
name: PKM2
is: B4DNK4

http://identifiers.org/biomodels.db/MODEL1310110061#_2aaf439e_3f35_4989_b45e_8ff3d4eba266
type: Species
has only substance units: false
initial amount: NaN
is encoded by: hsa:64781
is: SBO:0000252
initial concentration: NaN
constant: false
is: Q8TCT0
boundary condition: true
name: CERK

http://identifiers.org/biomodels.db/MODEL1310110061#_adc14d1a_6726_4505_a776_47f59f7ece1b
is: SBO:0000252
boundary condition: true
constant: false
has only substance units: false
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:3157
type: Species
name: HMGCS1

metaM dttp n
is: SBO:0000247
is: C00459
name: dTTP
is: HMDB01342
initial concentration: 1.0
initial amount: NaN
boundary condition: false
has only substance units: false
is: CHEBI:37568
type: Species
constant: false
notes: FORMULA: C10H13N2O14P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00368 EHMN_ABBREVIATION: C00459

metaR EX prostgh2 LPAREN e RPAREN
kinetic law: MODEL1310110061#
reactant: MODEL1310110061#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: prostaglandin H2(1-) exchange
type: Reaction

metaM 56dihindlcrbxlt c
has only substance units: false
boundary condition: false
type: Species
notes: FORMULA: C9H6NO4 CHARGE: -1 INCHI: InChI=1S/C9H7NO4/c11-7-2-4-1-6(9(13)14)10-5(4)3-8(7)12/h1-3,10-12H,(H,13,14)/p-1 EHMN_ABBREVIATION: C04185
is: CHEBI:16875
is: HMDB01253
initial concentration: 1.0
constant: false
is: SBO:0000247
initial amount: NaN
name: 5,6-dihydroxyindole-2-carboxylate

metaR CERT1rt
notes: GENE_ASSOCIATION: (10087.1) SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: PMID:12803919,PMID:14685229,PMID:15596449,PMID:15907394 NOTES:non-vesicular intracellular transport of ceramide
name: ceramide transport protein
product: MODEL1310110061#
reversible: true
type: Reaction
modifier: MODEL1310110061#
fast: false
is: SBO:0000185
kinetic law: MODEL1310110061#
reactant: MODEL1310110061#
is version of: http://identifiers.org/ec-code/2.7.11.1
is described by: ECO:0000304

metaR r1667
kinetic law: MODEL1310110061#
fast: false
product: MODEL1310110061#
reversible: true
is: SBO:0000185
is described by: ECO:0000000
reactant: MODEL1310110061#
modifier: MODEL1310110061#
type: Reaction
name: Y+LAT2 Utilized transport
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:

metaR GCHOLAt2
fast: false
reactant: MODEL1310110061#
is: SBO:0000185
notes: GENE_ASSOCIATION: (6554.1) or (6555.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12851823,PMID:7592981,PMID:8132774,PMID:9109432 NOTES:electrogenic uptake NJ
is described by: ECO:0000269
product: MODEL1310110061#
kinetic law: MODEL1310110061#
modifier: MODEL1310110061#
name: glycocholate transport via sodium cotransport
type: Reaction
reversible: false

metaM accoa c
is: CHEBI:57288
initial concentration: 1.0
is: C00024
type: Species
is: SBO:0000247
name: Acetyl-CoA
has only substance units: false
boundary condition: false
notes: FORMULA: C23H34N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00033 EHMN_ABBREVIATION: C00024
is: HMDB01206
constant: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110061#_e324afd7_67bc_49c7_90e1_6409da58aa22
is: SBO:0000252
name: _AI222095_1_e
initial amount: NaN
constant: false
boundary condition: true
is encoded by: hsa:AI222095
type: Species
initial concentration: NaN
has only substance units: false

metaM trdox c
is: C00343
notes: FORMULA: X CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00290 EHMN_ABBREVIATION: C00343
initial amount: NaN
boundary condition: false
initial concentration: 1.0
type: Species
is: SBO:0000247
constant: false
has only substance units: false
is: CHEBI:18191
name: Oxidized thioredoxin

metaR KYNAKGAT
name: L-Kynurenine:2-oxoglutarate aminotransferase
fast: false
is version of: http://identifiers.org/ec-code/2.6.1.7
type: Reaction
is version of: http://identifiers.org/ec-code/2.6.1.64
notes: GENE_ASSOCIATION: (51166.1) or (883.1) or (51166.2) SUBSYSTEM: Tryptophan metabolism EC Number: 2.6.1.7 Confidence Level: 4 AUTHORS: PMID:15016471 NOTES:SAB
kinetic law: MODEL1310110061#
reactant: MODEL1310110061#
is: SBO:0000176
modifier: MODEL1310110061#
reversible: false
product: MODEL1310110061#
is described by: ECO:0000269

metaM q10 e
is: CHEBI:46245
type: Species
is: SBO:0000247
has only substance units: false
name: ubiquinone-10
notes: FORMULA: C59H90O4 CHARGE: 0 INCHI: InChI=1S/C59H90O4/c1-44(2)24-15-25-45(3)26-16-27-46(4)28-17-29-47(5)30-18-31-48(6)32-19-33-49(7)34-20-35-50(8)36-21-37-51(9)38-22-39-52(10)40-23-41-53(11)42-43-55-54(12)56(60)58(62-13)59(63-14)57(55)61/h24,26,28,30,32,34,36,38,40,42H,15-23,25,27,29,31,33,35,37,39,41,43H2,1-14H3/b45-26+,46-28+,47-30+,48-32+,49-34+,50-36+,51-38+,52-40+,53-42+
boundary condition: false
is: HMDB01072
initial concentration: 1.0
constant: false
initial amount: NaN

metaR DPMVDc
is described by: ECO:0000134
notes: GENE_ASSOCIATION: (4597.1) SUBSYSTEM: Squalene and cholesterol synthesis EC Number: Confidence Level: 4 AUTHORS: Davidson, N. O., Magun, A. M. and Glickman, R. M. 2011. Enterocyte Lipid Absorption and Secretion. Comprehensive Physiology. 505?526, PMID: 17015489, PMID: 18216769, PMID: 6833883, PMID: 11229876. NOTES:Enterocytes stand next to liver in endogenous cholesterol synthesis. in rats they provide 25% of bodys cholesterol. the crypt epithelial cells synthesize maximum cholesterol when compared to other parts of the GI tract (PMCID: PMC292609). Reactions till farnesyl pyrophosphate operates in cytosol, however, further steps including squalene synthase operates in E.R (Harpers illustrated Biochemistry (2009) 28th edition, Lange medical publications, chapter 26, page 224-227). all the cholesterol synthesis enzymes have also been found in peroxisomes (PMID: 12121718), no evidence for enterocyte sub-cellular sites, so cytosolic reactions have been added according to Harper book. one proton added t product for elemental balancing.
reactant: MODEL1310110061#
type: Reaction
product: MODEL1310110061#
name: diphosphomevalonate decarboxylase, cytosol
modifier: MODEL1310110061#
kinetic law: MODEL1310110061#
reversible: false
is version of: http://identifiers.org/ec-code/4.1.1.33
fast: false
is: SBO:0000176

metaR PRFGS
is described by: ECO:0000269
reversible: false
fast: false
notes: GENE_ASSOCIATION: (5198.1) SUBSYSTEM: Purine synthesis EC Number: Confidence Level: 4 AUTHORS: NOTES:
kinetic law: MODEL1310110061#
name: phosphoribosylformylglycinamidine synthase
type: Reaction
is: SBO:0000176
is version of: http://identifiers.org/ec-code/6.3.5.3
modifier: MODEL1310110061#
reactant: MODEL1310110061#
product: MODEL1310110061#

metaR PIt7
is: SBO:0000185
is described by: ECO:0000269
reversible: true
fast: false
product: MODEL1310110061#
reactant: MODEL1310110061#
type: Reaction
name: phosphate transport in/out via three Na+ symporter
notes: GENE_ASSOCIATION: (10050.1) or (10786.1) or (10246.1) or (6568.1) or (6569.1) or (10568.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12750889,PMID:12811560,PMID:8815811 NOTES:Merged GPRs from PIt7 and PIt7r. May 2011 IT
kinetic law: MODEL1310110061#
modifier: MODEL1310110061#

metaM CE4872 c
initial concentration: 1.0
is: SBO:0000247
name: 3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-27-al
notes: FORMULA: C27H46O4 CHARGE: 0 INCHI: InChI=1/C27H46O4/c1-16(15-28)6-5-7-17(2)20-8-9-21-25-22(14-24(31)27(20,21)4)26(3)11-10-19(29)12-18(26)13-23(25)30/h15-25,29-31H,5-14H2,1-4H3/t16u,17-,18-,19+,20-,21-,22-,23+,24-,25-,26?,27-/m1/s1 EHMN_ABBREVIATION: CE4872
type: Species
has only substance units: false
constant: false
initial amount: NaN
boundary condition: false
is: CHEBI:15748
is: HMDB00127

http://identifiers.org/biomodels.db/MODEL1310110061#_7c6b18c5_d945_4f78_ad3d_28e75db6e66e
initial concentration: NaN
is: SBO:0000252
has only substance units: false
boundary condition: true
constant: false
initial amount: NaN
name: GGT7
type: Species
is: A0PJJ9
is encoded by: hsa:2686

metaR TMDK1m
modifier: MODEL1310110061#
is version of: http://identifiers.org/ec-code/2.7.1.21
reactant: MODEL1310110061#
notes: GENE_ASSOCIATION: (7084.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.1.21 Confidence Level: 4 AUTHORS: PMID:12535661,PMID:9342341 NOTES:TV
kinetic law: MODEL1310110061#
fast: false
product: MODEL1310110061#
type: Reaction
is described by: ECO:0000269
reversible: false
name: thymidine kinase (ATP:thymidine)
is: SBO:0000176

metaR PROt2r
is described by: ECO:0000304
type: Reaction
reversible: true
product: MODEL1310110061#
modifier: MODEL1310110061#
name: L-proline reversible transport via proton symport
kinetic law: MODEL1310110061#
notes: GENE_ASSOCIATION: (206358.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11390972,PMID:11959859 NOTES:NCD
reactant: MODEL1310110061#
is: SBO:0000185
fast: false

metaM adn m
is: HMDB00050
constant: false
boundary condition: false
has only substance units: false
notes: FORMULA: C10H13N5O4 CHARGE: 0 INCHI: InChI=1S/C10H13N5O4/c11-8-5-9(13-2-12-8)15(3-14-5)10-7(18)6(17)4(1-16)19-10/h2-4,6-7,10,16-18H,1H2,(H2,11,12,13)/t4-,6-,7-,10-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00196 EHMN_ABBREVIATION: C00212
is: SBO:0000247
name: adenosine
type: Species
initial amount: NaN
is: CHEBI:16335
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110061#_8c41ddbc_c837_4488_91fe_a8ff1edacd3a
is: Q5SPY7
type: Species
is encoded by: hsa:954
constant: false
initial amount: NaN
is: SBO:0000252
name: ENTPD2
boundary condition: true
initial concentration: NaN
has only substance units: false

metaR r1668
product: MODEL1310110061#
reversible: true
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reactant: MODEL1310110061#
type: Reaction
fast: false
name: Y+LAT2 Utilized transport
is: SBO:0000185
modifier: MODEL1310110061#
kinetic law: MODEL1310110061#

metaM rbt c
initial amount: NaN
is: SBO:0000247
is: CHEBI:15963
name: D-ribitol
notes: FORMULA: C5H12O5 CHARGE: 0 INCHI: InChI=1S/C5H12O5/c6-1-3(8)5(10)4(9)2-7/h3-10H,1-2H2/t3-,4+,5- HEPATONET_1.0_ABBREVIATION: HC00380
constant: false
type: Species
initial concentration: 1.0
boundary condition: false
is: HMDB00508
has only substance units: false

metaR EX fald LPAREN e RPAREN
kinetic law: MODEL1310110061#
reactant: MODEL1310110061#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of formaldehyde
type: Reaction

metaR FAOXC2442246x
is described by: ECO:0000269
kinetic law: MODEL1310110061#
is version of: http://identifiers.org/ec-code/4.2.1.107
modifier: MODEL1310110061#
name: Beta oxidation of long chain fatty acid
is: SBO:0000176
fast: false
type: Reaction
reversible: false
reactant: MODEL1310110061#
product: MODEL1310110061#
notes: GENE_ASSOCIATION: (51.1 and 3295.1 and 30.1) or (51.1 and 30.1 and 1962.1) or (30.1 and 51.2 and 1962.1) or (3295.1 and 30.1 and 51.2) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.74 Confidence Level: 4 AUTHORS: NOTES:_1 round beta ox - - in peroxisome, no fad, 1ste set of beta-ox is by acyl-coa oxidase (passes electrons directly to o2 -> h2o2) peroxisomal (very long chain FA) c24:4,n-6 -> c22:4, n-6 - final '6' in abbreviation indicates omega6 FA 4 step FAO lumped for 2 rounds also includes EC 1.1.1.35, 1.1.1.211, 1.3.3.6, 4.2.1.17, 4.2.1.74 NJ
is version of: http://identifiers.org/ec-code/1.1.1.35
is version of: http://identifiers.org/ec-code/2.3.1.16
is version of: http://identifiers.org/ec-code/1.3.3.6

metaM 2hb e
is: HMDB00008
has only substance units: false
boundary condition: false
type: Species
constant: false
is: SBO:0000247
notes: FORMULA: C4H7O3 CHARGE: -1 INCHI: InChI=1S/C4H8O3/c1-2-3(5)4(6)7/h3,5H,2H2,1H3,(H,6,7) HEPATONET_1.0_ABBREVIATION: HC01669 EHMN_ABBREVIATION: C05984
initial concentration: 1.0
name: 2-Hydroxybutyrate
initial amount: NaN
is: CHEBI:1148

metaR PIt8
reversible: true
modifier: MODEL1310110061#
product: MODEL1310110061#
reactant: MODEL1310110061#
type: Reaction
is: SBO:0000185
is described by: ECO:0000006
kinetic law: MODEL1310110061#
fast: false
notes: GENE_ASSOCIATION: (6574.1) or (6575.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12759754 NOTES:MM
name: phosphate transport in/out via Na+ symporter

metaR PGDI
name: Prostaglandin-H2 D-isomerase [Precursor]
is version of: http://identifiers.org/ec-code/2.5.1.18
product: MODEL1310110061#
notes: GENE_ASSOCIATION: (5730.1) or (27306.1) SUBSYSTEM: Eicosanoid metabolism EC Number: 5.3.99.2 Confidence Level: 4 AUTHORS: PMID:9065498,PMID:9353279 NOTES:noted on RER, but also cytoplasmic structures NJ
modifier: MODEL1310110061#
is version of: http://identifiers.org/ec-code/5.3.99.2
is: SBO:0000176
reversible: true
type: Reaction
reactant: MODEL1310110061#
fast: false
is described by: ECO:0000269
kinetic law: MODEL1310110061#

metaR r1552
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
product: MODEL1310110061#
kinetic law: MODEL1310110061#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is described by: ECO:0000000
fast: false
reversible: true
reactant: MODEL1310110061#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110061#_afd664cf_24b3_499f_90bd_5d960063d5c8
type: Species
is: O15269
initial amount: NaN
name: SPTLC1
initial concentration: NaN
has only substance units: false
is: SBO:0000252
boundary condition: true
is encoded by: hsa:10558
constant: false

http://identifiers.org/biomodels.db/MODEL1310110061#_21292625_0cdd_4137_9635_2edcc020fdd0
is encoded by: hsa:3177
initial amount: NaN
initial concentration: NaN
has only substance units: false
constant: false
is: Q14542
name: SLC29A2
is: SBO:0000252
type: Species
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110061#_270e91a4_83ce_4894_b52f_0ea94a5326c6
is encoded by: hsa:7360
has only substance units: false
is: SBO:0000252
initial amount: NaN
boundary condition: true
initial concentration: NaN
type: Species
constant: false
name: UGP2

metaR r1665
modifier: MODEL1310110061#
name: Y+LAT2 Utilized transport
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
fast: false
is: SBO:0000185
reactant: MODEL1310110061#
product: MODEL1310110061#
reversible: true
type: Reaction
kinetic law: MODEL1310110061#

metaR TYRDOPO
is: SBO:0000176
fast: false
reversible: false
is described by: ECO:0000269
reactant: MODEL1310110061#
type: Reaction
product: MODEL1310110061#
kinetic law: MODEL1310110061#
is version of: http://identifiers.org/ec-code/1.14.18.1
name: Tyrosine:dopa oxidase
notes: GENE_ASSOCIATION: (7299.1) SUBSYSTEM: Tyrosine metabolism EC Number: 1.14.18.1 Confidence Level: 4 AUTHORS: PMID:5294951 NOTES:SAB
modifier: MODEL1310110061#

metaR CTPtn
type: Reaction
product: MODEL1310110061#
reactant: MODEL1310110061#
name: CTP diffusion in nucleus
is: SBO:0000185
fast: false
reversible: true
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: NOTES:IT
kinetic law: MODEL1310110061#

http://identifiers.org/biomodels.db/MODEL1310110061#_1c8a9d75_21d6_4d80_92b9_073ee4c43cde
constant: false
is encoded by: hsa:AU149534
boundary condition: true
has only substance units: false
type: Species
initial concentration: NaN
initial amount: NaN
name: _AU149534_1_c
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110061#_a4c9aeb3_e0fd_4a75_b188_012d67281eb6
initial concentration: NaN
name: PPCS
initial amount: NaN
boundary condition: true
type: Species
constant: false
is: Q9HAB8
has only substance units: false
is encoded by: hsa:79717
is: SBO:0000252

metaR RE3011R
product: MODEL1310110061#
notes: GENE_ASSOCIATION: SUBSYSTEM: Eicosanoid metabolism EC Number: 1.1.1.1 Confidence Level: 0 AUTHORS: PMID:11368003,PMID:9799565,PMID:9862787 NOTES:
type: Reaction
fast: false
name: RE3011
reactant: MODEL1310110061#
is described by: ECO:0000000
is: SBO:0000176
reversible: true
kinetic law: MODEL1310110061#

http://identifiers.org/biomodels.db/MODEL1310110061#_c0480827_1cb7_4524_971e_2d709b69a9ca
is: SBO:0000252
name: SLC13A5
is: Q86YT5
constant: false
has only substance units: false
initial amount: NaN
boundary condition: true
type: Species
initial concentration: NaN
is encoded by: hsa:284111

metaR 4HOXPACDOX NADP
is: SBO:0000176
reversible: true
is version of: http://identifiers.org/ec-code/1.2.1.5
reactant: MODEL1310110061#
product: MODEL1310110061#
modifier: MODEL1310110061#
notes: GENE_ASSOCIATION: (222.1) or (220.1) or (221.1) or (218.1) SUBSYSTEM: Tyrosine metabolism EC Number: 1.2.1.5 Confidence Level: 2 AUTHORS: PMID:3753983 NOTES:SAB
is described by: ECO:0000304
kinetic law: MODEL1310110061#
fast: false
type: Reaction
name: 4-Hydroxyphenylacetaldehyde:NADP+ oxidoreductase

metaM hx2coa m
notes: FORMULA: C27H40N7O17P3S CHARGE: -4
constant: false
type: Species
is: SBO:0000247
is: HMDB02288
name: trans-Hex-2-enoyl-CoA
initial concentration: 1.0
boundary condition: false
has only substance units: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110061#_fedeae64_963c_46b6_9315_47f2193ac184
constant: false
is: SBO:0000252
boundary condition: true
type: Species
name: _AI348006_1_c
has only substance units: false
is encoded by: hsa:AI348006
initial concentration: NaN
initial amount: NaN

metaR NTD5m
product: MODEL1310110061#
is described by: ECO:0000269
name: 5'-nucleotidase (dTMP), mitochondrial
fast: false
reversible: false
type: Reaction
kinetic law: MODEL1310110061#
notes: GENE_ASSOCIATION: (56953.1) SUBSYSTEM: Nucleotide interconversion EC Number: 3.1.3.5 Confidence Level: 4 AUTHORS: PMID:10899995 NOTES:Wide specificity for 5'-nucleotides Also see EC 3.1.3.31
reactant: MODEL1310110061#
modifier: MODEL1310110061#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.1.3.5

metaM gtp c
is: SBO:0000247
initial concentration: 1.0
is: C00044
name: GTP
initial amount: NaN
has only substance units: false
boundary condition: false
constant: false
notes: FORMULA: C10H12N5O14P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00051 EHMN_ABBREVIATION: C00044
is: CHEBI:37565
type: Species
is: HMDB01273

metaR C160CPT2
modifier: MODEL1310110061#
is described by: ECO:0000269
kinetic law: MODEL1310110061#
reactant: MODEL1310110061#
is version of: http://identifiers.org/ec-code/2.3.1.21
notes: GENE_ASSOCIATION: (1376.1) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.21 Confidence Level: 4 AUTHORS: PMID:1528846,PMID:1988962 NOTES:TV
name: C160 transport into the mitochondria
product: MODEL1310110061#
reversible: false
fast: false
type: Reaction
is: SBO:0000176

metaR r0926
kinetic law: MODEL1310110061#
reactant: MODEL1310110061#
is described by: ECO:0000000
product: MODEL1310110061#
reversible: false
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:4358819 NOTES:
name: Postulated transport reaction
is: SBO:0000185
type: Reaction

metaR r1553
type: Reaction
product: MODEL1310110061#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reversible: true
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
kinetic law: MODEL1310110061#
fast: false
is described by: ECO:0000000
reactant: MODEL1310110061#

metaR r1666
modifier: MODEL1310110061#
is described by: ECO:0000000
reactant: MODEL1310110061#
product: MODEL1310110061#
reversible: true
type: Reaction
kinetic law: MODEL1310110061#
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
fast: false
is: SBO:0000185
name: Y+LAT2 Utilized transport

http://identifiers.org/biomodels.db/MODEL1310110061#_edf4298a_b93e_48a1_92d4_53d4f2957fb1
type: Species
boundary condition: true
is encoded by: hsa:2109
is: SBO:0000297
is encoded by: hsa:2108
name: ETFA:ETFB
initial amount: NaN
has only substance units: false
constant: false
initial concentration: NaN
has part: P13804

http://identifiers.org/biomodels.db/MODEL1310110061#_d216051e_fab8_4f19_98d9_7667aef3bf26
initial amount: NaN
type: Species
is: SBO:0000252
is: P38117
is encoded by: hsa:2109
initial concentration: NaN
has only substance units: false
boundary condition: true
name: ETFB
constant: false

http://identifiers.org/biomodels.db/MODEL1310110061#_29e172f2_37f5_4039_b036_69b7b3acc53e
initial amount: NaN
is: P11678
is: SBO:0000252
boundary condition: true
initial concentration: NaN
is encoded by: hsa:8288
type: Species
has only substance units: false
constant: false
name: EPX

http://identifiers.org/biomodels.db/MODEL1310110061#_1be028af_d0ce_4fec_bd89_ce986d23de3e
is: SBO:0000252
name: PRDX2
boundary condition: true
has only substance units: false
constant: false
initial amount: NaN
type: Species
initial concentration: NaN
is: P32119
is encoded by: hsa:7001

metaR r0881
is: SBO:0000185
fast: false
kinetic law: MODEL1310110061#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12107270,PMID:12739169,PMID:12829793,PMID:17245649,PMID:18375207,PMID:8476015,PMID:8557697,PMID:9786900 NOTES:
reactant: MODEL1310110061#
reversible: false
product: MODEL1310110061#
type: Reaction
name: Active transport
is described by: ECO:0000000

metaR EX ptrc LPAREN e RPAREN
kinetic law: MODEL1310110061#
reactant: MODEL1310110061#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of 1,4-butanediammonium
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110061#_bc6f7c68_344e_45a6_a7ec_248ce3186e7b
name: CYP4F3
initial concentration: NaN
is encoded by: hsa:4051
is: B7Z8Z3
has only substance units: false
boundary condition: true
initial amount: NaN
is: SBO:0000252
constant: false
type: Species

metaM 44mctr r
has only substance units: false
notes: FORMULA: C29H46O CHARGE: 0 INCHI: InChI=1S/C29H46O/c1-19(2)9-8-10-20(3)22-12-13-23-21-11-14-25-27(4,5)26(30)16-18-29(25,7)24(21)15-17-28(22,23)6/h9,13,20,22,25-26,30H,8,10-12,14-18H2,1-7H3/t20-,22-,25+,26+,28-,29-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01808 EHMN_ABBREVIATION: C11455
initial concentration: 1.0
name: 4,4-dimethyl-5alpha-cholesta-8,14,24-trien-3beta-ol
initial amount: NaN
is: SBO:0000247
is: HMDB01023
constant: false
is: CHEBI:17813
type: Species
boundary condition: false

metaR RE3000M
is described by: ECO:0000000
is: SBO:0000176
product: MODEL1310110061#
type: Reaction
name: RE3000
reversible: true
reactant: MODEL1310110061#
notes: GENE_ASSOCIATION: (1891.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 0 AUTHORS: PMID:10407780,PMID:7775433 NOTES:
kinetic law: MODEL1310110061#
fast: false
modifier: MODEL1310110061#

metaR EX tcynt LPAREN e RPAREN
kinetic law: MODEL1310110061#
reactant: MODEL1310110061#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Thiocyanate exchange
type: Reaction

metaR FAOXC225C226m
kinetic law: MODEL1310110061#
product: MODEL1310110061#
reactant: MODEL1310110061#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C22:5-->C22:6)m
type: Reaction

metaM ha pre1 e
initial concentration: 1.0
name: hyaluronan biosynthesis, precursor 1
type: Species
initial amount: NaN
is: CHEBI:16126
boundary condition: false
is: SBO:0000247
has only substance units: false
constant: false
notes: FORMULA: C14H20NO11 CHARGE: -1 INCHI: InChI=1S/C14H21NO11/c1-4(17)15-8-11(10(20)7(3-16)24-13(8)23)26-14-9(19)5(18)2-6(25-14)12(21)22/h2,5,7-11,13-14,16,18-20,23H,3H2,1H3,(H,15,17)(H,21,22)/t5-,7+,8+,9+,10+,11+,13+,14-/m0/s1

http://identifiers.org/biomodels.db/MODEL1310110061#_4b43daa2_3172_4b1c_acb1_104bf7c754e0
is encoded by: hsa:144195
boundary condition: true
has only substance units: false
name: SLC2A14
initial concentration: NaN
is: SBO:0000252
constant: false
type: Species
is: Q8TDB8
initial amount: NaN

metaM occoa m
initial concentration: 1.0
boundary condition: false
is: SBO:0000247
notes: FORMULA: C29H46N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00869 EHMN_ABBREVIATION: C01944
has only substance units: false
constant: false
name: Octanoyl-CoA (n-C8:0CoA)
is: C01944
is: CHEBI:57386
initial amount: NaN
is: HMDB01070
type: Species

metaM CE0693 m
boundary condition: false
type: Species
is: HMDB11123
initial concentration: 1.0
has only substance units: false
constant: false
initial amount: NaN
notes: FORMULA: C33H50N7O18P3S CHARGE: -4 INCHI: InChI=1/C33H54N7O18P3S/c1-4-5-6-7-8-9-10-11-21(41)16-24(43)62-15-14-35-23(42)12-13-36-31(46)28(45)33(2,3)18-55-61(52,53)58-60(50,51)54-17-22-27(57-59(47,48)49)26(44)32(56-22)40-20-39-25-29(34)37-19-38-30(25)40/h8-9,19-20,22,26-28,32,44-45H,4-7,10-18H2,1-3H3,(H,35,42)(H,36,46)(H,50,51)(H,52,53)(H2,34,37,38)(H2,47,48,49)/p-4/b9-8-/t22-,26+,27+,28u,32-/m0/s1 EHMN_ABBREVIATION: CE0693
is: CHEBI:28387
name: 3-oxolaur-6-cis-enoyl-CoA
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110061#_19291de4_5778_49fa_a707_f2ddcd128915
constant: false
is: SBO:0000252
has only substance units: false
type: Species
name: GLDC
initial amount: NaN
is: P23378
is encoded by: hsa:2731
initial concentration: NaN
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110061#_687c3b1f_d94d_430d_9283_162aa35717a1
initial concentration: NaN
constant: false
is: SBO:0000252
has only substance units: false
boundary condition: true
is encoded by: hsa:AI090874
type: Species
name: _AI090874_1_c
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110061#_990bbda1_80fd_49d6_9414_0abe7c71fe7a
initial concentration: NaN
is: SBO:0000252
constant: false
is encoded by: hsa:53354
type: Species
has only substance units: false
initial amount: NaN
name: PANK1
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110061#_d930e91f_3c7f_4117_b2ba_b814c7308b0f
type: Species
is encoded by: hsa:80308
initial concentration: NaN
is: Q8NFF5
constant: false
initial amount: NaN
boundary condition: true
name: FLAD1
has only substance units: false
is: SBO:0000252

metaM gbside hs g
name: globoside
notes: FORMULA: C44H79N2O22FULLRCO CHARGE: 0
boundary condition: false
has only substance units: false
type: Species
is: CHEBI:18259
initial amount: NaN
initial concentration: 1.0
constant: false
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110061#_19b63717_f197_4adf_8238_9a69aaa440ab
is: Q92820
boundary condition: true
constant: false
initial amount: NaN
is: SBO:0000252
initial concentration: NaN
has only substance units: false
is encoded by: hsa:8836
name: GGH
type: Species

metaM arg L e
initial concentration: 1.0
is: HMDB00517
type: Species
constant: false
boundary condition: false
is: CHEBI:32682
notes: FORMULA: C6H15N4O2 CHARGE: 1 INCHI: InChI=1S/C6H14N4O2/c7-4(5(11)12)2-1-3-10-6(8)9/h4H,1-3,7H2,(H,11,12)(H4,8,9,10)/p+1/t4-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00065
name: L-argininium(1+)
initial amount: NaN
has only substance units: false
is: SBO:0000247

metaR r0591
kinetic law: MODEL1310110061#
reversible: true
is: SBO:0000176
product: MODEL1310110061#
modifier: MODEL1310110061#
fast: false
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/1.2.1.5
name: Dephospho-CoA nucleotidohydrolase Pantothenate and CoA biosynthesis EC:3.6.1.9
type: Reaction
reactant: MODEL1310110061#
notes: GENE_ASSOCIATION: (220.1) or (218.1) or (221.1) or (222.1) or (U37519.1) SUBSYSTEM: CoA synthesis EC Number: 3.6.1.9 Confidence Level: 0 AUTHORS: PMID:11579996,PMID:11946484 NOTES:

metaM HC01459 x
notes: FORMULA: C48H76N7O21P3S CHARGE: -4 INCHI: InChI=1S/C48H80N7O21P3S/c1-24(28-8-9-29-36-30(19-34(59)48(28,29)6)47(5)13-11-27(56)17-26(47)18-32(36)58)7-10-31(57)25(2)45(64)80-16-15-50-35(60)12-14-51-43(63)40(62)46(3,4)21-73-79(70,71)76-78(68,69)72-20-33-39(75-77(65,66)67)38(61)44(74-33)55-23-54-37-41(49)52-22-53-42(37)55/h22-34,36,38-40,44,56-59,61-62H,7-21H2,1-6H3,(H,50,60)(H,51,63)(H,68,69)(H,70,71)(H2,49,52,53)(H2,65,66,67)/t24-,25?,26+,27-,28-,29+,30+,31?,32-,33-,34+,36+,38-,39-,40+,44-,47+,48-/m1/s1 EHMN_ABBREVIATION: C05450
boundary condition: false
initial concentration: 1.0
type: Species
constant: false
name: 3alpha,7alpha,12alpha,24-Tetrahydroxy-5beta-cholestanoyl-CoA
is: SBO:0000247
has only substance units: false
is: CHEBI:27458
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110061#_ea24340c_ba67_423d_ac65_1a374d0cc781
type: Species
initial concentration: NaN
is encoded by: hsa:1491
has only substance units: false
initial amount: NaN
boundary condition: true
is: B4E1R2
constant: false
name: CTH
is: SBO:0000252

metaM 2ddecdicoa m
is: SBO:0000247
is: C05279
has only substance units: false
initial concentration: 1.0
boundary condition: false
notes: FORMULA: C33H50N7O17P3S CHARGE: -4
type: Species
initial amount: NaN
name: 2,6-dodecadienoylcoa
constant: false
is: HMDB11123

http://identifiers.org/biomodels.db/MODEL1310110061#_4f1f6649_65d3_4939_b4c2_8b2ba5833810
initial amount: NaN
constant: false
has only substance units: false
is encoded by: hsa:8883
initial concentration: NaN
is: A8MU28
name: NAE1
boundary condition: true
is: SBO:0000252
type: Species

metaR CHOLPtg
is: SBO:0000185
is described by: ECO:0000000
type: Reaction
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 1 AUTHORS: NOTES:unknown mechanism for transport - no strong evidence to indicate further lysosomal or golgi metabolism NJ
product: MODEL1310110061#
kinetic law: MODEL1310110061#
name: choline phosphate intracellular transport
reactant: MODEL1310110061#
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110061#_6b962302_f08d_448a_bc61_878b0c8b6ab1
is: P04746
constant: false
type: Species
initial amount: NaN
is encoded by: hsa:279
is: SBO:0000252
has only substance units: false
name: AMY2A
boundary condition: true
initial concentration: NaN

metaR DCK1n
kinetic law: MODEL1310110061#
name: Deoxycytidine kinase, nuclear (ATP)
reversible: true
is described by: ECO:0000269
reactant: MODEL1310110061#
product: MODEL1310110061#
notes: GENE_ASSOCIATION: (1633.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.1.74 Confidence Level: 4 AUTHORS: PMID:10387103,PMID:12535661,PMID:9342341 NOTES:IT (2.7.1.74)
modifier: MODEL1310110061#
fast: false
is version of: http://identifiers.org/ec-code/2.7.1.74
type: Reaction
is: SBO:0000176

metaM pail hs c
initial concentration: 1.0
notes: FORMULA: C9H16O9PFULLRCO2FULLR2CO2 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC02009 EHMN_ABBREVIATION: C01194
type: Species
has only substance units: false
boundary condition: false
constant: false
initial amount: NaN
name: 1-phosphatidyl-1D-myo-inositol(1-)
is: SBO:0000247
is: CHEBI:57880

http://identifiers.org/biomodels.db/MODEL1310110061#_03b2f027_dfef_4dc2_a28d_208d5496de55
has only substance units: false
constant: false
is: SBO:0000252
is: Q9NRX3
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:56901
name: NDUFA4L2
type: Species
boundary condition: true

metaR FACOAL226
reactant: MODEL1310110061#
reversible: true
fast: false
name: fatty-acid--CoA ligase
is described by: ECO:0000000
product: MODEL1310110061#
type: Reaction
is version of: http://identifiers.org/ec-code/6.2.1.3
is: SBO:0000176
kinetic law: MODEL1310110061#
notes: GENE_ASSOCIATION: (2180.1) SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 4 AUTHORS: PMID:15292367 NOTES:NJ
modifier: MODEL1310110061#

metaR r0946
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.15
kinetic law: MODEL1310110061#
reversible: true
fast: false
reactant: MODEL1310110061#
is described by: ECO:0000000
product: MODEL1310110061#
is: SBO:0000185

metaM pro L c
is: SBO:0000247
notes: FORMULA: C5H9NO2 CHARGE: 0 INCHI: InChI=1S/C5H9NO2/c7-5(8)4-2-1-3-6-4/h4,6H,1-3H2,(H,7,8)/t4-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00145
initial amount: NaN
type: Species
initial concentration: 1.0
boundary condition: false
is: HMDB00162
name: L-proline
is: CHEBI:17203
constant: false
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110061#_af2cf0fe_e607_4fb6_adff_d974f7b0e18e
has only substance units: false
is: SBO:0000252
initial amount: NaN
is: P31939
constant: false
name: ATIC
boundary condition: true
type: Species
is encoded by: hsa:471
initial concentration: NaN

metaR EX fad LPAREN e RPAREN
kinetic law: MODEL1310110061#
reactant: MODEL1310110061#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of Flavin adenine dinucleotide oxidized
type: Reaction

metaR GLYC3Ptmc
type: Reaction
is described by: ECO:0000134
is: SBO:0000185
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: added during gap filling. No evidence found for such a reaction. NOTES:added during gap filling. No evidence found for such a reaction.
reversible: true
kinetic law: MODEL1310110061#
name: glycerol-3-phopshate transport, cytoplasm
product: MODEL1310110061#
reactant: MODEL1310110061#

metaM ach n
name: acetylcholine
has only substance units: false
boundary condition: false
is: SBO:0000247
type: Species
constant: false
is: CHEBI:15355
notes: FORMULA: C7H16NO2 CHARGE: 1 INCHI: InChI=1S/C7H16NO2/c1-7(9)10-6-5-8(2,3)4/h5-6H2,1-4H3/q+1 HEPATONET_1.0_ABBREVIATION: HC00877 EHMN_ABBREVIATION: C01996
initial amount: NaN
initial concentration: 1.0
is: HMDB00895

metaM kdn c
initial concentration: 1.0
is: SBO:0000247
has only substance units: false
is: HMDB00425
type: Species
boundary condition: false
notes: FORMULA: C9H15O9 CHARGE: -1 INCHI: InChI=1/C9H16O9/c10-2-5(13)7(15)8(16)6(14)3(11)1-4(12)9(17)18/h3,5-8,10-11,13-16H,1-2H2,(H,17,18)/t3-,5-,6+,7+,8+/m0/s1
constant: false
initial amount: NaN
name: 2-keto-3-deoxy-D-glycero-D-galactononic acid

metaR FAOXC142C122m
kinetic law: MODEL1310110061#
product: MODEL1310110061#
reactant: MODEL1310110061#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C14:2-->C12:2)m
type: Reaction

metaR r0590
type: Reaction
notes: GENE_ASSOCIATION: (220.1) or (218.1) or (221.1) or (222.1) or (U37519.1) SUBSYSTEM: CoA synthesis EC Number: 2.7.7.3 Confidence Level: 0 AUTHORS: PMID:11923312,PMID:11994049,PMID:13163064,PMID:15893380 NOTES:
modifier: MODEL1310110061#
fast: false
reactant: MODEL1310110061#
name: ATP:pantetheine-4-phosphate adenylyltransferase Pantothenate and CoA biosynthesis EC:2.7.7.3
kinetic law: MODEL1310110061#
is: SBO:0000176
product: MODEL1310110061#
reversible: false
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/1.2.1.5

http://identifiers.org/biomodels.db/MODEL1310110061#_f30e3c11_e841_494d_8561_6372a2ccaee5
is: P04745
is encoded by: hsa:277
boundary condition: true
constant: false
initial amount: NaN
initial concentration: NaN
is: SBO:0000252
type: Species
name: AMY1B
has only substance units: false

metaM gluside hs r
is: SBO:0000247
is: CHEBI:18368
constant: false
has only substance units: false
type: Species
boundary condition: false
name: D-glucosyl-N-acylsphingosine
notes: FORMULA: C24H46NO7FULLRCO CHARGE: 0 EHMN_ABBREVIATION: C01190
initial concentration: 1.0
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110061#_3646bb09_a63d_4b11_afdc_e3bb49946cf4
constant: false
initial concentration: NaN
name: ACSS1
type: Species
boundary condition: true
initial amount: NaN
has only substance units: false
is: SBO:0000252
is encoded by: hsa:84532
is: Q9NUB1

metaR GLYCt
fast: false
reversible: true
name: glycerol transport via channel
is: SBO:0000185
product: MODEL1310110061#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:9405233 NOTES:NCD
is described by: ECO:0000000
reactant: MODEL1310110061#
type: Reaction
kinetic law: MODEL1310110061#

metaR NH4t3r
modifier: MODEL1310110061#
reactant: MODEL1310110061#
is: SBO:0000185
type: Reaction
notes: GENE_ASSOCIATION: (57127.1) or (6005.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10444453,PMID:11024028,PMID:12920597,PMID:1417776,PMID:14966114,PMID:15284342,PMID:8595899 NOTES:
kinetic law: MODEL1310110061#
reversible: true
fast: false
name: ammonia transport via proton antiport
is described by: ECO:0000269
product: MODEL1310110061#

metaR SCPx
kinetic law: MODEL1310110061#
type: Reaction
is described by: ECO:0000269
is: SBO:0000176
reversible: false
is version of: http://identifiers.org/ec-code/2.3.1.176
name: peroxisomal thiolase 2
reactant: MODEL1310110061#
notes: GENE_ASSOCIATION: (6342.1) SUBSYSTEM: Bile acid synthesis EC Number: Confidence Level: 4 AUTHORS: NOTES:SCP has two transcripts, second isoform specific to peroxisomes, first is specific for cyt and mit need to double check stoichiometry - reaction cofactors (additional coa + release of prop coa) from BM (Roche) Biochemical Pathways NJ
fast: false
product: MODEL1310110061#
modifier: MODEL1310110061#

metaR r1551
reversible: true
is: SBO:0000185
fast: false
product: MODEL1310110061#
kinetic law: MODEL1310110061#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reactant: MODEL1310110061#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
type: Reaction

metaM lneldccoa m
boundary condition: false
has only substance units: false
is: http://identifiers.org/pubchem.compound/5462164
name: linoelaidyl coenzyme A
initial amount: NaN
type: Species
constant: false
is: SBO:0000247
initial concentration: 1.0
is: HMDB01064
notes: FORMULA: C39H62N7O17P3S CHARGE: -4

metaR TETHEX3t
reversible: true
is described by: ECO:0000000
fast: false
is: SBO:0000185
name: fatty acid transport via diffusion
product: MODEL1310110061#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11788354,PMID:12864740 NOTES:NJ
type: Reaction
kinetic law: MODEL1310110061#
reactant: MODEL1310110061#

metaR r0660
product: MODEL1310110061#
type: Reaction
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.5.1.2
is described by: ECO:0000000
reversible: true
reactant: MODEL1310110061#
name: (S)-3-Hydroxydodecanoyl-CoA hydro-lyase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:4.2.1.17
fast: false
notes: GENE_ASSOCIATION: (10637.1) or (5831.1) or (29920.1) or (65263.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.17 Confidence Level: 0 AUTHORS: PMID:8012501,PMID:8188243 NOTES:
modifier: MODEL1310110061#
kinetic law: MODEL1310110061#

metaM mi134p c
boundary condition: false
type: Species
is: HMDB01143
has only substance units: false
constant: false
initial amount: NaN
notes: FORMULA: C6H9O15P3 CHARGE: -6 INCHI: InChI=1S/C6H15O15P3/c7-1-2(8)5(20-23(13,14)15)6(21-24(16,17)18)3(9)4(1)19-22(10,11)12/h1-9H,(H2,10,11,12)(H2,13,14,15)(H2,16,17,18)/p-6/t1-,2-,3+,4+,5+,6+/m1/s1 EHMN_ABBREVIATION: C01243
is: CHEBI:58414
initial concentration: 1.0
is: SBO:0000247
name: 1D-myo-inositol 1,3,4-trisphosphate(6-)

metaR LPS
reactant: MODEL1310110061#
is: SBO:0000176
kinetic law: MODEL1310110061#
name: lipase
modifier: MODEL1310110061#
fast: false
reversible: false
notes: GENE_ASSOCIATION: (4023.1) SUBSYSTEM: Triacylglycerol synthesis EC Number: 3.1.1.3 Confidence Level: 4 AUTHORS: PMID:1969408 NOTES:carbonyl and extra H accounted for in R group NJ
is version of: http://identifiers.org/ec-code/3.1.1.34
product: MODEL1310110061#
type: Reaction
is described by: ECO:0000000

metaM c226coa x
is: C16169
boundary condition: false
name: cervonyl coenzyme A
is: SBO:0000247
has only substance units: false
constant: false
notes: FORMULA: C43H62N7O17P3S CHARGE: -4 INCHI: InChI=1/C43H66N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-34(52)71-27-26-45-33(51)24-25-46-41(55)38(54)43(2,3)29-64-70(61,62)67-69(59,60)63-28-32-37(66-68(56,57)58)36(53)42(65-32)50-31-49-35-39(44)47-30-48-40(35)50/h5-6,8-9,11-12,14-15,17-18,20-21,30-32,36-38,42,53-54H,4,7,10,13,16,19,22-29H2,1-3H3,(H,45,51)(H,46,55)(H,59,60)(H,61,62)(H2,44,47,48)(H2,56,57,58)/b6-5-,9-8-,12-11-,15-14-,18-17-,21-20-/t32-,36-,37-,38?,42-/m1/s1
is: http://identifiers.org/pubchem.compound/47205479
initial amount: NaN
type: Species
initial concentration: 1.0

metaR HXPRT
fast: false
is described by: ECO:0000269
type: Reaction
reversible: false
kinetic law: MODEL1310110061#
reactant: MODEL1310110061#
product: MODEL1310110061#
notes: GENE_ASSOCIATION: (3251.1) SUBSYSTEM: Nucleotide salvage pathway EC Number: 2.4.2.8 Confidence Level: 4 AUTHORS: PMID:3008106,PMID:6853490 NOTES:Guanine (see GUAPRT) and 6-mercaptopurine can replace hypoxanthine
is: SBO:0000176
modifier: MODEL1310110061#
name: hypoxanthine phosphoribosyltransferase (Hypoxanthine)
is version of: http://identifiers.org/ec-code/2.4.2.8

metaM estrones c
is: CHEBI:60050
initial concentration: 1.0
type: Species
is: SBO:0000247
boundary condition: false
is: HMDB01425
constant: false
initial amount: NaN
notes: FORMULA: C18H21O5S CHARGE: -1 INCHI: InChI=1S/C18H22O5S/c1-18-9-8-14-13-5-3-12(23-24(20,21)22)10-11(13)2-4-15(14)16(18)6-7-17(18)19/h3,5,10,14-16H,2,4,6-9H2,1H3,(H,20,21,22)/p-1/t14-,15-,16+,18+/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00961 EHMN_ABBREVIATION: C02538
name: estrone 3-sulfate(1-)
has only substance units: false

metaR r1669
fast: false
is: SBO:0000185
kinetic law: MODEL1310110061#
reversible: true
reactant: MODEL1310110061#
is described by: ECO:0000000
product: MODEL1310110061#
modifier: MODEL1310110061#
type: Reaction
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
name: Y+LAT2 Utilized transport

http://identifiers.org/biomodels.db/MODEL1310110061#_a1d52f85_e1ac_47f5_9535_f124e41435d1
constant: false
type: Species
has only substance units: false
is encoded by: hsa:1638
name: DCT
initial amount: NaN
initial concentration: NaN
boundary condition: true
is: SBO:0000252
is: P40126

metaR r2399
reversible: false
is: SBO:0000185
type: Reaction
is described by: ECO:0000000
product: MODEL1310110061#
kinetic law: MODEL1310110061#
fast: false
reactant: MODEL1310110061#
name: Mitochondrial Carrier (MC) TCDB:2.A.29.19.1
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172 NOTES:

metaM arg L c
initial amount: NaN
has only substance units: false
is: CHEBI:32682
name: L-argininium(1+)
boundary condition: false
notes: FORMULA: C6H15N4O2 CHARGE: 1 INCHI: InChI=1S/C6H14N4O2/c7-4(5(11)12)2-1-3-10-6(8)9/h4H,1-3,7H2,(H,11,12)(H4,8,9,10)/p+1/t4-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00065
is: SBO:0000247
type: Species
is: HMDB00517
initial concentration: 1.0
constant: false

metaM tyr L m
initial amount: NaN
notes: FORMULA: C9H11NO3 CHARGE: 0 INCHI: InChI=1S/C9H11NO3/c10-8(9(12)13)5-6-1-3-7(11)4-2-6/h1-4,8,11H,5,10H2,(H,12,13)/t8-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00085
type: Species
name: L-tyrosine
is: SBO:0000247
is: HMDB00158
is: CHEBI:17895
has only substance units: false
boundary condition: false
constant: false
initial concentration: 1.0

metaM q10 c
initial amount: NaN
is: HMDB01072
name: ubiquinone-10
initial concentration: 1.0
has only substance units: false
is: SBO:0000247
is: CHEBI:46245
notes: FORMULA: C59H90O4 CHARGE: 0 INCHI: InChI=1S/C59H90O4/c1-44(2)24-15-25-45(3)26-16-27-46(4)28-17-29-47(5)30-18-31-48(6)32-19-33-49(7)34-20-35-50(8)36-21-37-51(9)38-22-39-52(10)40-23-41-53(11)42-43-55-54(12)56(60)58(62-13)59(63-14)57(55)61/h24,26,28,30,32,34,36,38,40,42H,15-23,25,27,29,31,33,35,37,39,41,43H2,1-14H3/b45-26+,46-28+,47-30+,48-32+,49-34+,50-36+,51-38+,52-40+,53-42+ HEPATONET_1.0_ABBREVIATION: HC00329 EHMN_ABBREVIATION: C11378
constant: false
type: Species
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110061#_7c57d87d_3e50_4e6f_923b_6b929e77aae6
boundary condition: true
is: SBO:0000252
has only substance units: false
is: Q6YFQ2
is encoded by: hsa:125965
name: COX6B2
constant: false
type: Species
initial concentration: NaN
initial amount: NaN

metaR SUCCTD
kinetic law: MODEL1310110061#
product: MODEL1310110061#
reactant: MODEL1310110061#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: transport of succinate by diffusion
type: Reaction

metaM ala D c
is: SBO:0000247
type: Species
constant: false
initial amount: NaN
notes: FORMULA: C3H7NO2 CHARGE: 0 INCHI: InChI=1S/C3H7NO2/c1-2(4)3(5)6/h2H,4H2,1H3,(H,5,6)/t2-/m1/s1
has only substance units: false
is: CHEBI:15570
initial concentration: 1.0
boundary condition: false
name: D-alanine
is: HMDB01310

http://identifiers.org/biomodels.db/MODEL1310110061#_919f7df6_8053_411d_8cb0_7fe2dea2ff9f
has only substance units: false
initial amount: NaN
type: Species
initial concentration: NaN
boundary condition: true
name: PCK1
constant: false
is: SBO:0000252
is: P35558
is encoded by: hsa:5105

http://identifiers.org/biomodels.db/MODEL1310110061#_3948f6fa_bbfc_4c8a_99ec_3ab39dd8e00b
has only substance units: false
is encoded by: hsa:2194
initial amount: NaN
boundary condition: true
name: FASN
type: Species
is: P49327
is: SBO:0000252
initial concentration: NaN
constant: false

metaR URAt
is described by: ECO:0000269
name: uracil transport via facilated diffusion
notes: GENE_ASSOCIATION: (3177.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12006583,PMID:12838422 NOTES:IT
kinetic law: MODEL1310110061#
type: Reaction
reactant: MODEL1310110061#
modifier: MODEL1310110061#
reversible: true
product: MODEL1310110061#
fast: false
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110061#_80159a0a_7c97_4486_a9ec_c04611909d5d
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:761
has only substance units: false
type: Species
is: P07451
name: CA3
boundary condition: true
constant: false
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110061#_deb09c9e_189a_4070_bb5d_88da986a2001
boundary condition: true
constant: false
name: VNN3
is encoded by: hsa:55350
type: Species
has only substance units: false
is: SBO:0000252
initial concentration: NaN
initial amount: NaN

metaR r0944
is described by: ECO:0000000
reversible: true
is: SBO:0000185
product: MODEL1310110061#
name: Active transport
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:1526979 NOTES:
fast: false
type: Reaction
kinetic law: MODEL1310110061#
reactant: MODEL1310110061#

http://identifiers.org/biomodels.db/MODEL1310110061#_20acc751_f9d5_4106_9ad7_b90d05fccd4d
constant: false
initial concentration: NaN
type: Species
name: ETFB
is encoded by: hsa:2109
boundary condition: true
is: SBO:0000252
initial amount: NaN
has only substance units: false

metaR FACOAL224
reactant: MODEL1310110061#
modifier: MODEL1310110061#
kinetic law: MODEL1310110061#
is described by: ECO:0000000
type: Reaction
reversible: true
is: SBO:0000176
notes: GENE_ASSOCIATION: (2180.1) SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 4 AUTHORS: PMID:15292367 NOTES:NJ
product: MODEL1310110061#
name: fatty-acid--CoA ligase
is version of: http://identifiers.org/ec-code/6.2.1.3
fast: false

metaR DCTPtn
name: dCTP diffusion in nucleus
reactant: MODEL1310110061#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: NOTES:IT
product: MODEL1310110061#
is: SBO:0000185
fast: false
reversible: true
type: Reaction
kinetic law: MODEL1310110061#

metaR H2O2tp
is: SBO:0000185
name: hydrogen peroxide peroxisomal transport via diffusion
reactant: MODEL1310110061#
fast: false
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: PMID:2989289 NOTES:NCD
kinetic law: MODEL1310110061#
product: MODEL1310110061#
is described by: ECO:0000000
type: Reaction

metaM pro L e
initial amount: NaN
has only substance units: false
notes: FORMULA: C5H9NO2 CHARGE: 0 INCHI: InChI=1S/C5H9NO2/c7-5(8)4-2-1-3-6-4/h4,6H,1-3H2,(H,7,8)/t4-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00145
type: Species
is: HMDB00162
initial concentration: 1.0
boundary condition: false
constant: false
name: L-proline
is: CHEBI:17203
is: SBO:0000247

metaR EX biocyt LPAREN e RPAREN
kinetic law: MODEL1310110061#
reactant: MODEL1310110061#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Biocytin exchange
type: Reaction

metaR COQ7m
is described by: ECO:0000269
kinetic law: MODEL1310110061#
reversible: false
name: Ubiquinone biosynthesis COQ7
type: Reaction
modifier: MODEL1310110061#
product: MODEL1310110061#
fast: false
is: SBO:0000176
notes: GENE_ASSOCIATION: (10229.1) SUBSYSTEM: Ubiquinone synthesis EC Number: Confidence Level: 4 AUTHORS: PMID:11051212,PMID:1965190,PMID:7380842 NOTES:_1.14.13.- IT
reactant: MODEL1310110061#

metaR CDIPTr
modifier: MODEL1310110061#
product: MODEL1310110061#
type: Reaction
name: phosphatidylinositol synthase (Homo sapiens)
reversible: true
is: SBO:0000176
reactant: MODEL1310110061#
is version of: http://identifiers.org/ec-code/2.7.8.11
kinetic law: MODEL1310110061#
fast: false
notes: GENE_ASSOCIATION: (10423.1) or (10423.2) SUBSYSTEM: Glycerophospholipid metabolism EC Number: 2.7.8.11 Confidence Level: 4 AUTHORS: PMID:2425833 NOTES:NJ - reversibility of enzyme found in lit by NCD
is described by: ECO:0000000

metaM ppi r
type: Species
name: Diphosphate
constant: false
is: SBO:0000247
boundary condition: false
has only substance units: false
is: HMDB00250
initial amount: NaN
is: CHEBI:33019
is: C00013
notes: FORMULA: HO7P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00023 EHMN_ABBREVIATION: C00013
initial concentration: 1.0

metaR EX udpgal LPAREN e RPAREN
kinetic law: MODEL1310110061#
reactant: MODEL1310110061#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: UDP-D-galactose(2-) exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110061#_125ed87e_31e9_4b80_9c75_e4aca057a1fa
has only substance units: false
boundary condition: true
is encoded by: hsa:115286
constant: false
type: Species
initial amount: NaN
initial concentration: NaN
name: SLC25A26
is: SBO:0000252

metaR LACLt
fast: false
name: Lactate transport
product: MODEL1310110061#
reversible: false
kinetic law: MODEL1310110061#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 1 AUTHORS: PMCID: PMC1820816. NOTES:for regeneration of nad in peroxisomes, for providing nad to the beta oxidation
type: Reaction
reactant: MODEL1310110061#
is: SBO:0000185
is described by: ECO:0000134

metaR GLCt1r
reversible: true
notes: GENE_ASSOCIATION: (66035.1) or (6517.1) or (56606.1) or (154091.1) or (6513.1) or (11182.1) or (29988.1) or (6514.1) or (155184.1) or (56606.2) or (144195.1) or (6515.1) or (81031.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10421229,PMID:10821868,PMID:10860667,PMID:10860996,PMID:10970791,PMID:11247674,PMID:11583593,PMID:11592815,PMID:11780753,PMID:11832379,PMID:11882499,PMID:12135767,PMID:12483288,PMID:12504846,PMID:12750891,PMID:12914765,PMID:14739288,PMID:15033637,PMID:1701966,PMID:2182619,PMID:2656669,PMID:3103217,PMID:3170580,PMID:3399500,PMID:3839598,PMID:7926364,PMID:8504756,PMID:9230074,PMID:9770484 NOTES:
name: glucose transport (uniport)
type: Reaction
product: MODEL1310110061#
is described by: ECO:0000269
is: SBO:0000185
fast: false
reactant: MODEL1310110061#
modifier: MODEL1310110061#
kinetic law: MODEL1310110061#

metaM dcsptn1crn c
type: Species
initial amount: NaN
name: docosa-4,7,10,13,16-pentaenoyl carnitine
boundary condition: false
notes: FORMULA: C29H47NO4 CHARGE: 0 INCHI: InChI=1/C29H47NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-24-29(33)34-27(25-28(31)32)26-30(2,3)4/h9-10,12-13,15-16,18-19,21-22,27H,5-8,11,14,17,20,23-26H2,1-4H3/b10-9+,13-12+,16-15+,19-18+,22-21+
initial concentration: 1.0
has only substance units: false
is: SBO:0000247
is: HMDB06321
constant: false

metaR GALt1r
kinetic law: MODEL1310110061#
is described by: ECO:0000269
product: MODEL1310110061#
notes: GENE_ASSOCIATION: (29988.1) or (6513.1) or (6515.1) or (6514.1) or (81031.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10421229,PMID:10821868,PMID:10860996,PMID:11247674,PMID:11592815,PMID:11882499,PMID:12135767,PMID:12750891,PMID:1701966,PMID:2182619,PMID:3103217,PMID:3170580,PMID:3399500,PMID:3839598,PMID:7926364,PMID:8504756,PMID:9230074,PMID:9770484 NOTES:NCD
reversible: true
is: SBO:0000185
name: galactose transport (uniport)
type: Reaction
modifier: MODEL1310110061#
fast: false
reactant: MODEL1310110061#

metaR r0399
is version of: http://identifiers.org/ec-code/1.2.4.2
reactant: MODEL1310110061#
notes: GENE_ASSOCIATION: (4967.1) or (55753.1) SUBSYSTEM: Tetrahydrobiopterin metabolism EC Number: 1.14.16.1 Confidence Level: 0 AUTHORS: PMID:3298976,PMID:4074362 NOTES:
is: SBO:0000176
is described by: ECO:0000000
kinetic law: MODEL1310110061#
type: Reaction
modifier: MODEL1310110061#
product: MODEL1310110061#
fast: false
name: L-Phenylalanine,tetrahydrobiopterin:oxygen oxidoreductase (4-hydroxylating) Phenylalanine, tyrosine and tryptophan biosynthesis EC:1.14.16.1
reversible: true

metaR D3AIBTm
is: SBO:0000176
reactant: MODEL1310110061#
notes: GENE_ASSOCIATION: SUBSYSTEM: Pyrimidine catabolism EC Number: 2.6.1.40 Confidence Level: 4 AUTHORS: PMID:5773299 NOTES:MM
kinetic law: MODEL1310110061#
fast: false
type: Reaction
name: D-3-Amino-isobutanoate:pyruvate aminotransferase, mitochondrial
product: MODEL1310110061#
reversible: true
is described by: ECO:0000000

metaM mi14p n
is: CHEBI:58282
has only substance units: false
constant: false
initial concentration: 1.0
is: SBO:0000247
name: (1R,2R,3R,4R,5R,6S)-2,3,5,6-tetrahydroxy-4-(phosphonatooxy)cyclohexyl phosphate
notes: FORMULA: C6H10O12P2 CHARGE: -4 INCHI: InChI=1S/C6H14O12P2/c7-1-2(8)6(18-20(14,15)16)4(10)3(9)5(1)17-19(11,12)13/h1-10H,(H2,11,12,13)(H2,14,15,16)/p-4/t1-,2-,3-,4+,5+,6+/m1/s1 EHMN_ABBREVIATION: C01220
type: Species
boundary condition: false
initial amount: NaN
is: HMDB00968

metaM 2hb c
type: Species
notes: FORMULA: C4H7O3 CHARGE: -1 INCHI: InChI=1S/C4H8O3/c1-2-3(5)4(6)7/h3,5H,2H2,1H3,(H,6,7) HEPATONET_1.0_ABBREVIATION: HC01669 EHMN_ABBREVIATION: C05984
initial concentration: 1.0
boundary condition: false
has only substance units: false
is: SBO:0000247
is: HMDB00008
initial amount: NaN
constant: false
name: 2-Hydroxybutyrate
is: CHEBI:1148

metaR DCK2n
type: Reaction
modifier: MODEL1310110061#
reactant: MODEL1310110061#
fast: false
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (1633.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.1.74 Confidence Level: 4 AUTHORS: PMID:10387103,PMID:12535661,PMID:9342341 NOTES:IT (2.7.1.74)
product: MODEL1310110061#
kinetic law: MODEL1310110061#
is version of: http://identifiers.org/ec-code/2.7.1.74
is: SBO:0000176
name: Deoxycytidine kinase, nuclear (UTP)
reversible: true

metaR APOCF
is: SBO:0000176
kinetic law: MODEL1310110061#
reactant: MODEL1310110061#
reversible: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Biotin metabolism EC Number: Confidence Level: 2 AUTHORS: PMID:10191093 NOTES:IT faked reaction to balance reaction in human biotin metabolism
is described by: ECO:0000000
type: Reaction
product: MODEL1310110061#
fast: false
name: Apocarboxylase formation

metaR ACACt2
type: Reaction
product: MODEL1310110061#
fast: false
is described by: ECO:0000269
reactant: MODEL1310110061#
kinetic law: MODEL1310110061#
name: acetoacetate transport via proton symport
notes: GENE_ASSOCIATION: (6566.1) or (9194.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10510291,PMID:11101640,PMID:12739169,PMID:7835905,PMID:8476015,PMID:9425115,PMID:9508842,PMID:9649795,PMID:9786900,PMID:9824713 NOTES:originally named AACTP NCD
is: SBO:0000185
reversible: true
modifier: MODEL1310110061#

metaR r0885
modifier: MODEL1310110061#
is version of: http://identifiers.org/ec-code/1.3.1.38
name: Mitochondrial Carrier (MC) TCDB:2.A.29.2.7
kinetic law: MODEL1310110061#
reactant: MODEL1310110061#
product: MODEL1310110061#
reversible: true
fast: false
type: Reaction
is: SBO:0000185
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (AA526438.1) or (H17063.1) or (51102.1) or (55825.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:15845418,PMID:16600197,PMID:9639574 NOTES:

metaR ACt2m
type: Reaction
product: MODEL1310110061#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: PMID:10198029,PMID:15755952 NOTES:NCD
reversible: true
kinetic law: MODEL1310110061#
name: acetate mitochondrial transport via proton symport
is described by: ECO:0000000
reactant: MODEL1310110061#
fast: false
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110061#_8f4323d9_fae7_46c1_848b_5de12f274405
name: _R14373_1_x
initial concentration: NaN
is encoded by: hsa:R14373
is: SBO:0000252
constant: false
boundary condition: true
has only substance units: false
type: Species
initial amount: NaN

metaR NACHEX25ly
product: MODEL1310110061#
reversible: false
type: Reaction
fast: false
is version of: http://identifiers.org/ec-code/3.2.1.52
name: beta-N-acetylhexosaminidase, lysosomal
notes: GENE_ASSOCIATION: (3073.1 and 3074.1) or (3073.1) or (3074.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.52 Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12706724,PMID:8993162 NOTES:NCD
is described by: ECO:0000000
reactant: MODEL1310110061#
is: SBO:0000176
kinetic law: MODEL1310110061#
modifier: MODEL1310110061#

http://identifiers.org/biomodels.db/MODEL1310110061#_f1c8d10b_3dc1_4330_9d27_c8874247e2d6
initial amount: NaN
is: SBO:0000252
initial concentration: NaN
is encoded by: hsa:54995
is: Q9NWU1
has only substance units: false
type: Species
constant: false
boundary condition: true
name: OXSM

http://identifiers.org/biomodels.db/MODEL1310110061#_2d41876c_d8c0_405d_82a5_f5f2bb8f5230
type: Species
boundary condition: true
constant: false
is: O95470
initial concentration: NaN
name: SGPL1
has only substance units: false
initial amount: NaN
is encoded by: hsa:8879
is: SBO:0000252

metaM xol7a r
notes: FORMULA: C27H46O2 CHARGE: 0 INCHI: InChI=1S/C27H46O2/c1-18(2)7-6-14-27(5,29)24-11-10-22-21-9-8-19-17-20(28)12-15-25(19,3)23(21)13-16-26(22,24)4/h8,18,20-24,28-29H,6-7,9-17H2,1-5H3/t20-,21-,22-,23-,24-,25-,26-,27-/m0/s1 EHMN_ABBREVIATION: C03594
has only substance units: false
initial amount: NaN
name: 20-hydroxycholesterol
boundary condition: false
is: CHEBI:1296
type: Species
initial concentration: 1.0
is: SBO:0000247
is: HMDB01496
constant: false

metaR r0942
kinetic law: MODEL1310110061#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11165387,PMID:12110547,PMID:12145274,PMID:15918910,PMID:3896131,PMID:9386672 NOTES:
type: Reaction
fast: false
product: MODEL1310110061#
reactant: MODEL1310110061#
is: SBO:0000185
name: Neurotransmitter:Sodium Symporter (NSS) TCDB:2.A.22.3.4
is described by: ECO:0000000
reversible: true

metaR ALACYSNaEx
reversible: false
kinetic law: MODEL1310110061#
type: Reaction
modifier: MODEL1310110061#
fast: false
is described by: ECO:0000269
reactant: MODEL1310110061#
product: MODEL1310110061#
name: L-alanine/L-cysteine Na-dependent exchange (Ala-L in)
is: SBO:0000185
notes: GENE_ASSOCIATION: (6509.1) or (6510.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14530974 NOTES:SAB see Kanai and Hediger 2004 (2003), PMID 14530974

metaR EX HC00250 LPAREN e RPAREN
kinetic law: MODEL1310110061#
reactant: MODEL1310110061#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of hydrosulfide
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110061#_973d0dec_3a5a_4885_a4c3_69132f09e594
initial amount: NaN
is: SBO:0000252
constant: false
initial concentration: NaN
is encoded by: hsa:594
boundary condition: true
is: P21953
type: Species
name: BCKDHB
has only substance units: false

metaM 3docopencoa m
name: 3,7,10,13,16-docosapentenoylcoa
is: HMDB02288
initial amount: NaN
type: Species
has only substance units: false
constant: false
is: SBO:0000247
notes: FORMULA: C43H64N7O17P3S CHARGE: -4
boundary condition: false
initial concentration: 1.0

metaM ala D e
is: SBO:0000247
notes: FORMULA: C3H7NO2 CHARGE: 0 INCHI: InChI=1S/C3H7NO2/c1-2(4)3(5)6/h2H,4H2,1H3,(H,5,6)/t2-/m1/s1
has only substance units: false
is: HMDB01310
name: D-alanine
initial amount: NaN
initial concentration: 1.0
is: CHEBI:15570
type: Species
boundary condition: false
constant: false

metaM lnlncg r
constant: false
initial amount: NaN
is: HMDB03073
is: SBO:0000247
name: gamma-linolenate
has only substance units: false
is: CHEBI:32391
type: Species
boundary condition: false
initial concentration: 1.0
notes: FORMULA: C18H29O2 CHARGE: -1 INCHI: InChI=1S/C18H30O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20/h6-7,9-10,12-13H,2-5,8,11,14-17H2,1H3,(H,19,20)/p-1/b7-6-,10-9-,13-12- HEPATONET_1.0_ABBREVIATION: HC01757 EHMN_ABBREVIATION: C06426

http://identifiers.org/biomodels.db/MODEL1310110061#_f2ef3284_79a8_48da_8315_94df5f4446a0
boundary condition: true
name: NMNAT3
is: Q96T66
initial amount: NaN
has only substance units: false
is encoded by: hsa:349565
is: SBO:0000252
constant: false
type: Species
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110061#_b5fddf0e_17c3_4ead_a0d0_1d22ad172fb0
initial concentration: NaN
boundary condition: true
is encoded by: hsa:51205
is: SBO:0000252
initial amount: NaN
type: Species
is: Q9NPH0
has only substance units: false
constant: false
name: ACP6

metaR EX cyan LPAREN e RPAREN
kinetic law: MODEL1310110061#
reactant: MODEL1310110061#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Hydrogen cyanide exchange
type: Reaction

metaM nh4 e
type: Species
boundary condition: false
constant: false
has only substance units: false
notes: FORMULA: H4N CHARGE: 1 INCHI: InChI=1S/H3N/h1H3/p+1 HEPATONET_1.0_ABBREVIATION: HC00765 EHMN_ABBREVIATION: C01342
is: SBO:0000247
is: HMDB00051
name: ammonium
initial amount: NaN
initial concentration: 1.0
is: CHEBI:28938

http://identifiers.org/biomodels.db/MODEL1310110061#_a371bcbc_2bcf_4218_8df2_229512e7ca10
has only substance units: false
is encoded by: hsa:5291
constant: false
is: B4DER4
initial amount: NaN
initial concentration: NaN
type: Species
is: SBO:0000252
boundary condition: true
name: PIK3CB

metaM andrstrn r
boundary condition: false
has only substance units: false
is: SBO:0000247
is: HMDB00031
is: CHEBI:16032
initial amount: NaN
constant: false
name: androsterone
initial concentration: 1.0
notes: FORMULA: C19H30O2 CHARGE: 0 INCHI: InChI=1S/C19H30O2/c1-18-9-7-13(20)11-12(18)3-4-14-15-5-6-17(21)19(15,2)10-8-16(14)18/h12-16,20H,3-11H2,1-2H3/t12-,13+,14-,15-,16-,18-,19-/m0/s1 EHMN_ABBREVIATION: C00523
type: Species

http://identifiers.org/biomodels.db/MODEL1310110061#_496ad191_e2a2_4b30_9b0b_940b6df86979
has only substance units: false
name: GSTZ1
initial amount: NaN
is encoded by: hsa:2954
boundary condition: true
constant: false
type: Species
is: SBO:0000252
initial concentration: NaN

metaR EX thf LPAREN e RPAREN
kinetic law: MODEL1310110061#
reactant: MODEL1310110061#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 5,6,7,8-Tetrahydrofolate exchange
type: Reaction

metaM lgnccoa x
type: Species
constant: false
is: HMDB06526
initial amount: NaN
notes: FORMULA: C45H78N7O17P3S CHARGE: -4 INCHI: InChI=1/C45H82N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-24-25-36(54)73-29-28-47-35(53)26-27-48-43(57)40(56)45(2,3)31-66-72(63,64)69-71(61,62)65-30-34-39(68-70(58,59)60)38(55)44(67-34)52-33-51-37-41(46)49-32-50-42(37)52/h32-34,38-40,44,55-56H,4-31H2,1-3H3,(H,47,53)(H,48,57)(H,61,62)(H,63,64)(H2,46,49,50)(H2,58,59,60)/t34-,38?,39-,40+,44-/m1/s1
name: lignocericyl coenzyme A
boundary condition: false
has only substance units: false
initial concentration: 1.0
is: SBO:0000247

metaM ump c
notes: FORMULA: C9H11N2O9P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00105 EHMN_ABBREVIATION: C00105
initial amount: NaN
initial concentration: 1.0
has only substance units: false
is: SBO:0000247
type: Species
is: C00105
constant: false
is: HMDB00288
is: CHEBI:57865
name: UMP
boundary condition: false

metaR It
type: Reaction
fast: false
reactant: MODEL1310110061#
product: MODEL1310110061#
notes: GENE_ASSOCIATION: (160728.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:1217270 NOTES:NCD
reversible: true
kinetic law: MODEL1310110061#
name: Iodide uniport
is described by: ECO:0000269
is: SBO:0000185
modifier: MODEL1310110061#

metaR EX 3aib D LPAREN e RPAREN
kinetic law: MODEL1310110061#
reactant: MODEL1310110061#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: D-3-Amino-isobutanoate exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110061#_2a22b815_380b_4112_8c8e_be081d9f6f92
name: ENTPD8
type: Species
constant: false
is: Q5MY95
has only substance units: false
initial amount: NaN
is encoded by: hsa:377841
boundary condition: true
initial concentration: NaN
is: SBO:0000252

metaM fucfucgalacglcgalgluside hs g
constant: false
name: Leb glycolipid
has only substance units: false
is: CHEBI:57455
notes: FORMULA: C56H99N2O30FULLRCO CHARGE: 0
is: C00445
initial amount: NaN
is: HMDB01354
initial concentration: 1.0
type: Species
boundary condition: false
is: SBO:0000247

metaR EX gthrd LPAREN e RPAREN
kinetic law: MODEL1310110061#
reactant: MODEL1310110061#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Reduced glutathione exchange
type: Reaction

metaR r1660
kinetic law: MODEL1310110061#
modifier: MODEL1310110061#
is described by: ECO:0000000
reactant: MODEL1310110061#
type: Reaction
fast: false
reversible: true
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
product: MODEL1310110061#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110061#_531054a7_7853_48b4_8a55_3e3f6173d1b3
is: P23921
initial concentration: NaN
constant: false
initial amount: NaN
has only substance units: false
is encoded by: hsa:6240
name: RRM1
type: Species
boundary condition: true
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110061#_5a2e5edd_90d6_4fa3_9097_07bfb84e08ba
initial concentration: NaN
initial amount: NaN
type: Species
is encoded by: hsa:AF116616
has only substance units: false
name: _AF116616_1_m
boundary condition: true
constant: false
is: SBO:0000252

metaM ppcoa c
is: C00100
boundary condition: false
initial concentration: 1.0
type: Species
is: HMDB01275
name: Propanoyl-CoA
initial amount: NaN
constant: false
is: SBO:0000247
has only substance units: false
is: CHEBI:57392
notes: FORMULA: C24H36N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00101 EHMN_ABBREVIATION: C00100

metaR ALAGLNexR
fast: false
type: Reaction
modifier: MODEL1310110061#
product: MODEL1310110061#
reactant: MODEL1310110061#
is described by: ECO:0000304
kinetic law: MODEL1310110061#
name: L-alanine/glutamine reversible exchange
notes: GENE_ASSOCIATION: (6520.1) and (56301.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10734121,PMID:10863037,PMID:14770310 NOTES:
is: SBO:0000185
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110061#_309bb7ef_cf8b_4f85_8e6d_f4f80c4c3e36
is encoded by: hsa:10559
type: Species
is: SBO:0000252
constant: false
has only substance units: false
initial amount: NaN
boundary condition: true
name: SLC35A1
initial concentration: NaN
is: P78382

http://identifiers.org/biomodels.db/MODEL1310110061#_499774e8_283b_43d8_bdfb_41ae9499a96c
is encoded by: hsa:9167
boundary condition: true
initial concentration: NaN
is: SBO:0000252
has only substance units: false
initial amount: NaN
constant: false
is: Q6FGA0
name: COX7A2L
type: Species

http://identifiers.org/biomodels.db/MODEL1310110061#_590cfa93_6006_4862_a3e6_bb98fbfc10a7
initial concentration: NaN
has part: Q8WYR1
boundary condition: true
name: PIK3R5:PIK3CG
is encoded by: hsa:23533
is: SBO:0000297
has only substance units: false
type: Species
constant: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110061#_2c3dcbaf_b9fb_48be_b737_b07d9c703037
is: P11169
constant: false
name: SLC2A3
boundary condition: true
initial concentration: NaN
type: Species
has only substance units: false
is: SBO:0000252
is encoded by: hsa:6515
initial amount: NaN

metaR ADNtm
notes: GENE_ASSOCIATION: (2030.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:10722669,PMID:12838422,PMID:14607828 NOTES:IT
kinetic law: MODEL1310110061#
is: SBO:0000185
reversible: true
product: MODEL1310110061#
type: Reaction
modifier: MODEL1310110061#
name: adenosine facilated transport in mitochondria
is described by: ECO:0000269
reactant: MODEL1310110061#
fast: false

http://identifiers.org/biomodels.db/MODEL1310110061#_5a1f0de1_c6d3_43f5_85ed_2ba67ab3d35f
constant: false
initial amount: NaN
name: PAICS
has only substance units: false
type: Species
boundary condition: true
is encoded by: hsa:10606
is: SBO:0000252
is: P22234
initial concentration: NaN

metaR PI45P5P
notes: GENE_ASSOCIATION: (8867.1) or (56623.1) or (4952.1) or (8871.1) or (8867.2) or (4952.2) or (3633.1) SUBSYSTEM: Inositol phosphate metabolism EC Number: 3.1.3.36 Confidence Level: 4 AUTHORS: PMID:10764818,PMID:12915445,PMID:7721860,PMID:7761412 NOTES:NCD
type: Reaction
reversible: false
is version of: http://identifiers.org/ec-code/3.1.3.36
reactant: MODEL1310110061#
kinetic law: MODEL1310110061#
product: MODEL1310110061#
modifier: MODEL1310110061#
is described by: ECO:0000000
fast: false
name: phosphatidylinositol-4,5-bisphosphate 5-phosphatase
is: SBO:0000176

metaR IPDDIx
reactant: MODEL1310110061#
kinetic law: MODEL1310110061#
is: SBO:0000176
name: isopentenyl-diphosphate D-isomerase
fast: false
is version of: http://identifiers.org/ec-code/5.3.3.2
type: Reaction
modifier: MODEL1310110061#
notes: GENE_ASSOCIATION: (3422.1) or (91734.1) SUBSYSTEM: Cholesterol metabolism EC Number: 5.3.3.2 Confidence Level: 4 AUTHORS: PMID:11111079 NOTES:peroxisomal version - NJ
reversible: true
product: MODEL1310110061#
is described by: ECO:0000134

metaR r0940
is described by: ECO:0000000
is: SBO:0000185
reversible: true
type: Reaction
name: Free diffusion
product: MODEL1310110061#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
kinetic law: MODEL1310110061#
reactant: MODEL1310110061#

metaR ACETONEt2m
fast: false
reactant: MODEL1310110061#
is described by: ECO:0000000
modifier: MODEL1310110061#
type: Reaction
product: MODEL1310110061#
reversible: true
kinetic law: MODEL1310110061#
notes: GENE_ASSOCIATION: (6566.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: NOTES:NCD
is: SBO:0000185
name: acetone mitochondrial transport via proton symport

metaM CE5101 m
constant: false
type: Species
initial concentration: 1.0
boundary condition: false
is: CHEBI:57795
is: SBO:0000247
notes: FORMULA: C11H15O16P2R2 CHARGE: -3 EHMN_ABBREVIATION: CE5101
initial amount: NaN
name: 1-phosphatidyl-1D-myo-inositol 5-phosphate(3-)
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110061#_b25a5ab1_6fb4_45bb_9024_496d50869ec2
name: PI4KB
has only substance units: false
is encoded by: hsa:5298
is: Q9UBF8
type: Species
initial concentration: NaN
constant: false
is: SBO:0000252
initial amount: NaN
boundary condition: true

metaR RBFK
modifier: MODEL1310110061#
is: SBO:0000176
type: Reaction
reversible: false
is described by: ECO:0000269
reactant: MODEL1310110061#
notes: GENE_ASSOCIATION: (55312.1) SUBSYSTEM: Vitamin B2 metabolism EC Number: Confidence Level: 4 AUTHORS: NOTES:
is version of: http://identifiers.org/ec-code/2.7.1.26
kinetic law: MODEL1310110061#
fast: false
name: riboflavin kinase
product: MODEL1310110061#

metaR ACONTm
fast: false
reversible: true
notes: GENE_ASSOCIATION: (50.1) SUBSYSTEM: Citric acid cycle EC Number: 4.2.1.3 Confidence Level: 0 AUTHORS: PMID:10419470,PMID:17244191,PMID:17244192 NOTES:IF. Biochemical
is: SBO:0000176
modifier: MODEL1310110061#
type: Reaction
name: Aconitate hydratase
is version of: http://identifiers.org/ec-code/4.2.1.3
kinetic law: MODEL1310110061#
reactant: MODEL1310110061#
is described by: ECO:0000134
product: MODEL1310110061#

metaM tetdecdicoa m
notes: FORMULA: C35H54N7O17P3S CHARGE: -4
initial amount: NaN
initial concentration: 1.0
constant: false
boundary condition: false
is: SBO:0000247
type: Species
name: 5,8-tetradecadienoylcoa
has only substance units: false
is: HMDB02288

http://identifiers.org/biomodels.db/MODEL1310110061#_554e51e8_4ab4_49ef_a058_e280a5ce2c79
constant: false
is: Q86XP1
boundary condition: true
is encoded by: hsa:160851
has only substance units: false
initial concentration: NaN
initial amount: NaN
is: SBO:0000252
type: Species
name: DGKH

metaM trdox m
boundary condition: false
has only substance units: false
notes: FORMULA: X CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00290 EHMN_ABBREVIATION: C00343
initial concentration: 1.0
type: Species
constant: false
name: Oxidized thioredoxin
is: CHEBI:18191
is: SBO:0000247
initial amount: NaN

metaM mmcoa S m
constant: false
has only substance units: false
type: Species
is: CHEBI:57327
initial concentration: 1.0
initial amount: NaN
is: HMDB02310
name: (S)-methylmalonyl-CoA(5-)
boundary condition: false
is: SBO:0000247
notes: FORMULA: C25H35N7O19P3S CHARGE: -5 INCHI: InChI=1S/C25H40N7O19P3S/c1-12(23(37)38)24(39)55-7-6-27-14(33)4-5-28-21(36)18(35)25(2,3)9-48-54(45,46)51-53(43,44)47-8-13-17(50-52(40,41)42)16(34)22(49-13)32-11-31-15-19(26)29-10-30-20(15)32/h10-13,16-18,22,34-35H,4-9H2,1-3H3,(H,27,33)(H,28,36)(H,37,38)(H,43,44)(H,45,46)(H2,26,29,30)(H2,40,41,42)/p-5/t12-,13+,16+,17+,18-,22+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00495

http://identifiers.org/biomodels.db/MODEL1310110061#_a7763de2_e025_47cf_a7e1_9c5d7a3099ad
is encoded by: hsa:8034
is: SBO:0000252
constant: false
initial concentration: NaN
is: P16260
boundary condition: true
type: Species
name: SLC25A16
initial amount: NaN
has only substance units: false

metaM nh4 c
is: CHEBI:28938
is: SBO:0000247
initial amount: NaN
boundary condition: false
type: Species
has only substance units: false
constant: false
name: Ammonium
is: C01342
initial concentration: 1.0
is: HMDB00051
notes: FORMULA: H4N CHARGE: 1 HEPATONET_1.0_ABBREVIATION: HC00765 EHMN_ABBREVIATION: C01342

metaR r2443
type: Reaction
product: MODEL1310110061#
fast: false
is described by: ECO:0000000
reversible: false
is: SBO:0000185
name: Proposed Fatty Acid Transporter (FAT) TCDB:4.C.1.1.5
kinetic law: MODEL1310110061#
reactant: MODEL1310110061#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110061#_f6da80f2_1ac1_46d1_bd7f_038f989b5a18
name: _728226_1_e
has only substance units: false
boundary condition: true
initial concentration: NaN
constant: false
initial amount: NaN
is encoded by: hsa:728226
is: SBO:0000252
type: Species

http://identifiers.org/biomodels.db/MODEL1310110061#_39a28f57_df93_4762_ad02_b4402778fb05
constant: false
is: Q96E98
is: SBO:0000252
initial concentration: NaN
has only substance units: false
initial amount: NaN
is encoded by: hsa:6005
name: RHAG
type: Species
boundary condition: true

metaR r0941
fast: false
is described by: ECO:0000000
reversible: true
kinetic law: MODEL1310110061#
type: Reaction
product: MODEL1310110061#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:911815 NOTES:
name: Free diffusion
reactant: MODEL1310110061#

metaM msa m
boundary condition: false
is: SBO:0000247
is: HMDB11111
has only substance units: false
is: CHEBI:33190
initial concentration: 1.0
notes: FORMULA: C3H3O3 CHARGE: -1 INCHI: InChI=1S/C3H4O3/c4-2-1-3(5)6/h2H,1H2,(H,5,6)/p-1 HEPATONET_1.0_ABBREVIATION: HC00203 EHMN_ABBREVIATION: C00222
constant: false
name: 3-oxopropanoate
type: Species
initial amount: NaN

metaM estrones e
constant: false
initial amount: NaN
has only substance units: false
boundary condition: false
type: Species
initial concentration: 1.0
notes: FORMULA: C18H21O5S CHARGE: -1 INCHI: InChI=1S/C18H22O5S/c1-18-9-8-14-13-5-3-12(23-24(20,21)22)10-11(13)2-4-15(14)16(18)6-7-17(18)19/h3,5,10,14-16H,2,4,6-9H2,1H3,(H,20,21,22)/p-1/t14-,15-,16+,18+/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00961 EHMN_ABBREVIATION: C02538
name: estrone 3-sulfate(1-)
is: HMDB01425
is: CHEBI:60050
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110061#_06301e02_e81d_423d_bfe4_e451657d0ce4
initial amount: NaN
has only substance units: false
boundary condition: true
is encoded by: hsa:8560
initial concentration: NaN
is: SBO:0000252
name: DEGS1
constant: false
type: Species

metaR DURIPP
fast: false
reversible: true
modifier: MODEL1310110061#
is: SBO:0000176
notes: GENE_ASSOCIATION: (4860.1) or (151531.1) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: PMID:11278417,PMID:12849978,PMID:6087295,PMID:9305963 NOTES:JLR
is described by: ECO:0000269
kinetic law: MODEL1310110061#
type: Reaction
name: deoxyuridine phosphorylase
product: MODEL1310110061#
is version of: http://identifiers.org/ec-code/2.4.2.1
is version of: http://identifiers.org/ec-code/2.4.2.3
reactant: MODEL1310110061#

http://identifiers.org/biomodels.db/MODEL1310110061#_bd1e17bb_5473_45bc_95b5_3f65079da9b4
has only substance units: false
is: Q6LEN6
constant: false
type: Species
is: SBO:0000252
initial concentration: NaN
name: CHAT
boundary condition: true
initial amount: NaN
is encoded by: hsa:1103

metaR EX eicostet LPAREN e RPAREN
kinetic law: MODEL1310110061#
reactant: MODEL1310110061#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: eicosatetranoic acid exchange
type: Reaction

metaM trdrd m
is: SBO:0000247
boundary condition: false
is: CHEBI:15967
name: Reduced thioredoxin
initial concentration: 1.0
initial amount: NaN
has only substance units: false
notes: FORMULA: XH2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00289 EHMN_ABBREVIATION: C00342
type: Species
constant: false

http://identifiers.org/biomodels.db/MODEL1310110061#_3dcea098_7918_4cf4_9c8c_0f2307b4f93b
type: Species
is encoded by: hsa:23236
boundary condition: true
initial amount: NaN
constant: false
initial concentration: NaN
has only substance units: false
name: PLCB1
is: SBO:0000252

metaM maltttr e
initial amount: NaN
initial concentration: 1.0
is: http://identifiers.org/pubchem.compound/5141
has only substance units: false
name: Maltotetraose
type: Species
is: HMDB01296
constant: false
is: C02052
is: SBO:0000247
boundary condition: false
notes: FORMULA: C24H42O21 CHARGE: 0 INCHI: InChI=1/C24H42O21/c25-1-5-9(29)10(30)15(35)22(40-5)44-19-7(3-27)42-24(17(37)12(19)32)45-20-8(4-28)41-23(16(36)13(20)33)43-18-6(2-26)39-21(38)14(34)11(18)31/h5-38H,1-4H2/t5-,6-,7-,8-,9-,10+,11-,12-,13-,14-,15-,16-,17-,18-,19-,20-,21u,22-,23-,24-/m1/s1 EHMN_ABBREVIATION: C02052

http://identifiers.org/biomodels.db/MODEL1310110061#_87af1170_62b7_4378_a9a6_9e85f877e44f
name: ENTPD3
is: SBO:0000252
boundary condition: true
is encoded by: hsa:956
type: Species
has only substance units: false
initial concentration: NaN
constant: false
initial amount: NaN
is: O75355

http://identifiers.org/biomodels.db/MODEL1310110061#_5dddac95_f2ab_47e8_b77f_02e2c144b819
type: Species
initial concentration: NaN
has only substance units: false
constant: false
initial amount: NaN
is encoded by: hsa:10840
is: O75891
name: ALDH1L1
is: SBO:0000252
boundary condition: true

metaR EX dlnlcg LPAREN e RPAREN
kinetic law: MODEL1310110061#
reactant: MODEL1310110061#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: dihomo-gamma-linolenic acid (n-6) exchange
type: Reaction

metaR r2019
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
type: Reaction
product: MODEL1310110061#
kinetic law: MODEL1310110061#
is: SBO:0000185
modifier: MODEL1310110061#
reversible: false
is described by: ECO:0000000
reactant: MODEL1310110061#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.15
fast: false

metaM etfrd m
constant: false
name: Electron transfer flavoprotein reduced
has only substance units: false
type: Species
is: CHEBI:17263
is: HMDB00145
initial concentration: 1.0
initial amount: NaN
boundary condition: false
notes: FORMULA: RH2 CHARGE: 0
is: SBO:0000247

metaM Rtotal2coa c
initial amount: NaN
name: R total 2 coenzyme A
constant: false
is: HMDB00095
initial concentration: 1.0
type: Species
notes: FORMULA: CO2FULLR2C21H31N7O15P3S CHARGE: -4
has only substance units: false
is: SBO:0000247
boundary condition: false
is: C00055
is: CHEBI:60377

metaR HMGCOASim
notes: GENE_ASSOCIATION: (3158.1) SUBSYSTEM: Cholesterol metabolism EC Number: 4.1.3.5 Confidence Level: 4 AUTHORS: PMID:7893153 NOTES:NCD New assignment: EC-2.3.3.10 EC-4.1.3.5 (created 1961, deleted 2002). Enzyme Commission mitochondrial enzyme NJ Made irreversible to match KEGG data for S. aureus
fast: false
is version of: http://identifiers.org/ec-code/2.3.3.10
reversible: false
product: MODEL1310110061#
name: Hydroxymethylglutaryl CoA synthase (ir)
modifier: MODEL1310110061#
type: Reaction
is described by: ECO:0000269
reactant: MODEL1310110061#
kinetic law: MODEL1310110061#
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110061#_5117766d_0e61_4263_8a23_01028c3ae817
constant: false
is encoded by: hsa:5293
type: Species
boundary condition: true
has part: A7E2E0
initial concentration: NaN
has part: Q92569
name: PIK3CD:PIK3R3
has only substance units: false
initial amount: NaN
is: SBO:0000297
is encoded by: hsa:8503

metaM btcoa m
is: CHEBI:57371
type: Species
name: Butanoyl-CoA
is: SBO:0000247
is: C00136
initial amount: NaN
is: HMDB01088
has only substance units: false
boundary condition: false
notes: FORMULA: C25H38N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00134 EHMN_ABBREVIATION: C00136
initial concentration: 1.0
constant: false

metaM nmn c
type: Species
is: SBO:0000247
is: HMDB00229
constant: false
is: C00455
initial amount: NaN
has only substance units: false
initial concentration: 1.0
is: CHEBI:14649
notes: FORMULA: C11H14N2O8P CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00366 EHMN_ABBREVIATION: C00455
name: NMN
boundary condition: false

metaR EX urate LPAREN e RPAREN
kinetic law: MODEL1310110061#
reactant: MODEL1310110061#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Urate exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110061#_0a0cd393_a828_40b2_9d67_05232e05bdf3
is: SBO:0000252
has only substance units: false
is encoded by: hsa:92483
initial amount: NaN
initial concentration: NaN
type: Species
boundary condition: true
name: LDHAL6B
is: Q9BYZ2
constant: false

http://identifiers.org/biomodels.db/MODEL1310110061#_f0d04fc5_cae6_43c9_a92a_b965ad138d98
constant: false
has only substance units: false
is: P48448
is: SBO:0000252
initial amount: NaN
boundary condition: true
is encoded by: hsa:222
initial concentration: NaN
type: Species
name: ALDH3B2

http://identifiers.org/biomodels.db/MODEL1310110061#_ef1c0298_7889_46eb_84cc_684ee1d2737e
is: SBO:0000252
name: SLC25A11
initial concentration: NaN
type: Species
constant: false
boundary condition: true
is: F5GY65
has only substance units: false
is encoded by: hsa:8402
initial amount: NaN

metaR RE2998M
type: Reaction
reactant: MODEL1310110061#
reversible: false
is: SBO:0000176
notes: GENE_ASSOCIATION: (51.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.3.6 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:7775433 NOTES:
is described by: ECO:0000000
kinetic law: MODEL1310110061#
modifier: MODEL1310110061#
product: MODEL1310110061#
is version of: http://identifiers.org/ec-code/1.3.3.6
name: RE2998
fast: false

http://identifiers.org/biomodels.db/MODEL1310110061#_f004afa4_44a6_4ebc_b49a_41ed0636e5ac
name: SLC3A2:SLC7A6
boundary condition: true
type: Species
initial concentration: NaN
constant: false
is encoded by: hsa:9057
has part: Q92536
has only substance units: false
is: SBO:0000297
initial amount: NaN

metaM cholcoaone x
has only substance units: false
is: CHEBI:58507
notes: FORMULA: C48H74N7O21P3S CHARGE: -4 INCHI: InChI=1S/C48H78N7O21P3S/c1-24(28-8-9-29-36-30(19-34(59)48(28,29)6)47(5)13-11-27(56)17-26(47)18-32(36)58)7-10-31(57)25(2)45(64)80-16-15-50-35(60)12-14-51-43(63)40(62)46(3,4)21-73-79(70,71)76-78(68,69)72-20-33-39(75-77(65,66)67)38(61)44(74-33)55-23-54-37-41(49)52-22-53-42(37)55/h22-30,32-34,36,38-40,44,56,58-59,61-62H,7-21H2,1-6H3,(H,50,60)(H,51,63)(H,68,69)(H,70,71)(H2,49,52,53)(H2,65,66,67)/p-4/t24-,25?,26+,27-,28-,29+,30+,32-,33-,34+,36+,38-,39-,40+,44-,47+,48-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01473 EHMN_ABBREVIATION: C05467
is: SBO:0000247
is: HMDB06891
type: Species
boundary condition: false
name: 3alpha,7alpha,12alpha-trihydroxy-24-oxo-5beta-cholestan-26-oyl-CoA(4-)
initial concentration: 1.0
initial amount: NaN
constant: false

http://identifiers.org/biomodels.db/MODEL1310110061#_b87c2ce7_8ca5_4f92_8aa8_6184bf814e1a
type: Species
name: COX5B
boundary condition: true
initial amount: NaN
is encoded by: hsa:1329
is: SBO:0000252
initial concentration: NaN
constant: false
has only substance units: false
is: Q53YB7

metaR TYRTA
type: Reaction
is version of: http://identifiers.org/ec-code/2.6.1.1
is: SBO:0000176
fast: false
reversible: true
kinetic law: MODEL1310110061#
modifier: MODEL1310110061#
product: MODEL1310110061#
is described by: ECO:0000269
name: tyrosine transaminase
notes: GENE_ASSOCIATION: (2805.1) SUBSYSTEM: Tyrosine metabolism EC Number: 2.6.1.5 Confidence Level: 4 AUTHORS: NOTES:
reactant: MODEL1310110061#

metaR ACt2r
is described by: ECO:0000000
product: MODEL1310110061#
fast: false
reactant: MODEL1310110061#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:9651205 NOTES:NCD
reversible: true
kinetic law: MODEL1310110061#
name: acetate reversible transport via proton symport
is: SBO:0000185
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110061#_b41444a6_1543_4008_b0f3_8c60ec93c3b1
boundary condition: true
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:29920
name: PYCR2
has only substance units: false
type: Species
constant: false
is: Q96C36
is: SBO:0000252

metaM bilglcur c
notes: FORMULA: C39H44N4O12 CHARGE: 0 INCHI: InChI=1S/C39H44N4O12/c1-7-20-19(6)36(50)43-27(20)14-25-18(5)23(10-12-31(46)54-39-34(49)32(47)33(48)35(55-39)38(52)53)29(41-25)15-28-22(9-11-30(44)45)17(4)24(40-28)13-26-16(3)21(8-2)37(51)42-26/h7-8,13-14,32-35,39-41,47-49H,1-2,9-12,15H2,3-6H3,(H,42,51)(H,43,50)(H,44,45)(H,52,53)/p-2/b26-13+,27-14+/t32-,33-,34+,35-,39+/m0/s1 EHMN_ABBREVIATION: C03374
is: SBO:0000247
initial amount: NaN
is: CHEBI:57767
initial concentration: 1.0
type: Species
boundary condition: false
constant: false
has only substance units: false
name: mono(glucosyluronic acid)bilirubin(2-)

metaM fald c
notes: FORMULA: CH2O CHARGE: 0 INCHI: InChI=1S/CH2O/c1-2/h1H2 HEPATONET_1.0_ABBREVIATION: HC00070 EHMN_ABBREVIATION: C00067
has only substance units: false
initial concentration: 1.0
is: CHEBI:16842
is: SBO:0000247
type: Species
is: HMDB01426
constant: false
initial amount: NaN
name: formaldehyde
boundary condition: false

metaR MI34PP
modifier: MODEL1310110061#
product: MODEL1310110061#
is version of: http://identifiers.org/ec-code/3.1.3.66
is: SBO:0000176
fast: false
name: inositol-3,4-bisphosphate 4-phosphatase
kinetic law: MODEL1310110061#
notes: GENE_ASSOCIATION: (3631.2) or (3631.1) or (8821.1) SUBSYSTEM: Inositol phosphate metabolism EC Number: 3.1.3.66 Confidence Level: 4 AUTHORS: PMID:2906139,PMID:7608176,PMID:9295334 NOTES:NCD
reactant: MODEL1310110061#
is described by: ECO:0000269
reversible: false
type: Reaction

metaR r0668
reactant: MODEL1310110061#
is described by: ECO:0000000
name: CTP:N-acylneuraminate cytidylyltransferase Aminosugars metabolism EC:2.7.7.43
product: MODEL1310110061#
modifier: MODEL1310110061#
fast: false
is version of: http://identifiers.org/ec-code/2.4.2.19
kinetic law: MODEL1310110061#
reversible: true
type: Reaction
notes: GENE_ASSOCIATION: (AI539321.1) or (23475.1) SUBSYSTEM: Unassigned EC Number: 2.7.7.43 Confidence Level: 0 AUTHORS: PMID:1577759,PMID:422125,PMID:4288894,PMID:4803836,PMID:9689047 NOTES:
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110061#_68f91b09_bc69_4d1c_b761_ce2418aaeb64
boundary condition: true
is encoded by: hsa:2720
name: GLB1
type: Species
constant: false
is: SBO:0000252
is: P16278
initial concentration: NaN
has only substance units: false
initial amount: NaN

metaM oxa c
constant: false
is: SBO:0000247
initial concentration: 1.0
is: CHEBI:30623
notes: FORMULA: C2O4 CHARGE: -2 INCHI: InChI=1S/C2H2O4/c3-1(4)2(5)6/h(H,3,4)(H,5,6)/p-2 HEPATONET_1.0_ABBREVIATION: HC00195 EHMN_ABBREVIATION: C00209
initial amount: NaN
has only substance units: false
boundary condition: false
name: oxalate(2-)
is: HMDB02329
type: Species

http://identifiers.org/biomodels.db/MODEL1310110061#_44b2255d_831e_4613_bef9_51ceca4016bf
initial amount: NaN
is encoded by: hsa:6390
initial concentration: NaN
constant: false
is: P21912
boundary condition: true
name: SDHB
is: SBO:0000252
type: Species
has only substance units: false

metaR RE0915E
kinetic law: MODEL1310110061#
product: MODEL1310110061#
modifier: MODEL1310110061#
is: SBO:0000176
fast: false
type: Reaction
notes: GENE_ASSOCIATION: (280.1) or (84569.1) or (276.1) or (277.1) or (278.1) or (279.1) or (276.1) or (277.1) or (278.1) or (279.1) SUBSYSTEM: Starch and sucrose metabolism EC Number: 3.2.1.1 Confidence Level: 0 AUTHORS: PMID:385176,PMID:8528071,PMID:890964 NOTES:
reversible: true
reactant: MODEL1310110061#
is version of: http://identifiers.org/ec-code/3.2.1.17
is described by: ECO:0000000
name: RE0915
is version of: http://identifiers.org/ec-code/3.2.1.1

http://identifiers.org/biomodels.db/MODEL1310110061#_49578b4c_e3a9_4f6f_920f_cd5907e638a4
initial concentration: NaN
is: SBO:0000252
has only substance units: false
initial amount: NaN
name: _AI769281_1_e
type: Species
is encoded by: hsa:AI769281
boundary condition: true
constant: false

metaM urate e
initial amount: NaN
name: Urate
is: SBO:0000247
constant: false
boundary condition: false
is: CHEBI:17775
is: C00366
notes: FORMULA: C5H4N4O3 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00310 EHMN_ABBREVIATION: C00366
is: HMDB00289
type: Species
has only substance units: false
initial concentration: 1.0

metaR r1559
is: SBO:0000185
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reversible: true
kinetic law: MODEL1310110061#
is described by: ECO:0000000
reactant: MODEL1310110061#
product: MODEL1310110061#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110061#_20aa5e55_96e4_4e37_a56b_e23a227f41ae
initial concentration: NaN
is: B4DWD7
initial amount: NaN
is encoded by: hsa:79901
type: Species
has only substance units: false
name: CYBRD1
boundary condition: true
constant: false
is: SBO:0000252

metaR HISD
modifier: MODEL1310110061#
type: Reaction
is: SBO:0000176
is described by: ECO:0000269
product: MODEL1310110061#
reactant: MODEL1310110061#
reversible: false
is version of: http://identifiers.org/ec-code/4.3.1.3
name: histidase
notes: GENE_ASSOCIATION: (3034.1) SUBSYSTEM: Histidine metabolism EC Number: 4.3.1.3 Confidence Level: 4 AUTHORS: PMID:8530107 NOTES:
fast: false
kinetic law: MODEL1310110061#

http://identifiers.org/biomodels.db/MODEL1310110061#_46d70b0c_4baf_4a23_a575_bf9021e613ad
has only substance units: false
is: Q6LEN6
name: CHAT
constant: false
type: Species
is encoded by: hsa:1103
initial concentration: NaN
is: SBO:0000252
initial amount: NaN
boundary condition: true

metaR r1664
kinetic law: MODEL1310110061#
is described by: ECO:0000000
reversible: true
reactant: MODEL1310110061#
type: Reaction
is: SBO:0000185
product: MODEL1310110061#
modifier: MODEL1310110061#
name: Y+LAT2 Utilized transport
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
fast: false

http://identifiers.org/biomodels.db/MODEL1310110061#_a8e996e8_cc88_46db_a16b_ff412cf50a0b
is: B7Z6S9
constant: false
has only substance units: false
type: Species
boundary condition: true
initial concentration: NaN
initial amount: NaN
name: GBA
is: SBO:0000252
is encoded by: hsa:2629

http://identifiers.org/biomodels.db/MODEL1310110061#_13684d7f_f670_4684_87b0_f9ed0e136578
type: Species
initial amount: NaN
is encoded by: hsa:117248
name: GALNTL2
is: Q8N3T1
has only substance units: false
constant: false
initial concentration: NaN
boundary condition: true
is: SBO:0000252

metaM fucfucgalacglcgalgluside hs c
is: C00445
initial concentration: 1.0
is: HMDB01354
has only substance units: false
notes: FORMULA: C56H99N2O30FULLRCO CHARGE: 0
is: CHEBI:57455
initial amount: NaN
is: SBO:0000247
type: Species
name: Leb glycolipid
boundary condition: false
constant: false

metaR EX fucfucgalacglcgalgluside hs LPAREN e RPAREN
kinetic law: MODEL1310110061#
reactant: MODEL1310110061#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Leb glycolipid exchange
type: Reaction

metaM ppi x
is: C00013
constant: false
is: CHEBI:33019
initial amount: NaN
is: SBO:0000247
initial concentration: 1.0
boundary condition: false
is: HMDB00250
type: Species
name: Diphosphate
has only substance units: false
notes: FORMULA: HO7P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00023 EHMN_ABBREVIATION: C00013

metaR EX pectintchol LPAREN e RPAREN
kinetic law: MODEL1310110061#
reactant: MODEL1310110061#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for pectin-taurocholic acid complex
type: Reaction

metaM malttr e
is: CHEBI:27931
has only substance units: false
name: maltotriose
initial concentration: 1.0
boundary condition: false
is: SBO:0000247
constant: false
is: HMDB01262
is: C01835
initial amount: NaN
type: Species
notes: FORMULA: C18H32O16 CHARGE: 0 INCHI: InChI=1S/C18H32O16/c19-1-4-7(22)8(23)12(27)17(31-4)34-15-6(3-21)32-18(13(28)10(15)25)33-14-5(2-20)30-16(29)11(26)9(14)24/h4-29H,1-3H2/t4-,5-,6-,7-,8+,9-,10-,11-,12-,13-,14-,15-,16+,17-,18-/m1/s1 EHMN_ABBREVIATION: C01835

metaR DCSPTN1t
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11788354,PMID:12864740 NOTES:NJ
type: Reaction
is: SBO:0000185
reactant: MODEL1310110061#
is described by: ECO:0000000
kinetic law: MODEL1310110061#
fast: false
product: MODEL1310110061#
name: fatty acid transport via diffusion
reversible: true

metaR HSD17B7r
kinetic law: MODEL1310110061#
is described by: ECO:0000134
product: MODEL1310110061#
is version of: http://identifiers.org/ec-code/1.1.1.62
is: SBO:0000176
modifier: MODEL1310110061#
notes: GENE_ASSOCIATION: (51478.1) SUBSYSTEM: Steroid metabolism EC Number: 1.1.1.62 Confidence Level: 4 AUTHORS: PMID:12732193 NOTES:Recombinant cDNA from human granulosa cells were purified and used in an enzyme assay, Km and Kcat values quantified
type: Reaction
fast: false
name: testicular 17-beta-hydroxysteroid dehydrogenase
reversible: false
reactant: MODEL1310110061#

http://identifiers.org/biomodels.db/MODEL1310110061#_fa2d50f4_c1c2_4535_a0f5_242e5517780a
is: P24752
is: SBO:0000252
boundary condition: true
type: Species
constant: false
is encoded by: hsa:38
initial amount: NaN
name: ACAT1
initial concentration: NaN
has only substance units: false

metaR FAOXC163Gm
kinetic law: MODEL1310110061#
product: MODEL1310110061#
reactant: MODEL1310110061#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: isomerization(C16:3)gm
type: Reaction

metaM 20ahchsterol m
initial amount: NaN
boundary condition: false
notes: FORMULA: C27H46O2 CHARGE: 0 INCHI: InChI=1S/C27H46O2/c1-18(2)7-6-14-27(5,29)24-11-10-22-21-9-8-19-17-20(28)12-15-25(19,3)23(21)13-16-26(22,24)4/h8,18,20-24,28-29H,6-7,9-17H2,1-5H3/t20-,21-,22-,23-,24-,25-,26-,27-/m0/s1 EHMN_ABBREVIATION: C05500
is: HMDB06283
has only substance units: false
is: CHEBI:1296
name: 20-hydroxycholesterol
type: Species
is: SBO:0000247
constant: false
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110061#_95420a0d_1e6d_4358_83ca_bbd1bfb546b7
is encoded by: hsa:51022
is: SBO:0000252
initial amount: NaN
initial concentration: NaN
type: Species
has only substance units: false
constant: false
name: GLRX2
boundary condition: true

metaR r1661
reversible: true
product: MODEL1310110061#
fast: false
kinetic law: MODEL1310110061#
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is: SBO:0000185
is described by: ECO:0000000
reactant: MODEL1310110061#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
modifier: MODEL1310110061#
type: Reaction

metaM dcyt c
type: Species
constant: false
is: C00881
notes: FORMULA: C9H13N3O4 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00574 EHMN_ABBREVIATION: C00881
is: CHEBI:15698
is: SBO:0000247
initial concentration: 1.0
has only substance units: false
name: Deoxycytidine
boundary condition: false
is: HMDB00014
initial amount: NaN

metaR GLYCtm
name: glycerol transport
type: Reaction
kinetic law: MODEL1310110061#
reversible: true
is: SBO:0000185
is described by: ECO:0000000
product: MODEL1310110061#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: NOTES:TDV
fast: false
reactant: MODEL1310110061#

metaM bilglcur e
has only substance units: false
notes: FORMULA: C39H44N4O12 CHARGE: 0 INCHI: InChI=1S/C39H44N4O12/c1-7-20-19(6)36(50)43-27(20)14-25-18(5)23(10-12-31(46)54-39-34(49)32(47)33(48)35(55-39)38(52)53)29(41-25)15-28-22(9-11-30(44)45)17(4)24(40-28)13-26-16(3)21(8-2)37(51)42-26/h7-8,13-14,32-35,39-41,47-49H,1-2,9-12,15H2,3-6H3,(H,42,51)(H,43,50)(H,44,45)(H,52,53)/p-2/b26-13+,27-14+/t32-,33-,34+,35-,39+/m0/s1 EHMN_ABBREVIATION: C03374
initial amount: NaN
is: CHEBI:57767
constant: false
type: Species
initial concentration: 1.0
boundary condition: false
name: mono(glucosyluronic acid)bilirubin(2-)
is: SBO:0000247

metaM 2mpdhl m
is: SBO:0000247
initial concentration: 1.0
constant: false
notes: FORMULA: C12H23NO2S2 CHARGE: 0 INCHI: InChI=1S/C12H23NO2S2/c1-9(2)12(15)17-8-7-10(16)5-3-4-6-11(13)14/h9-10,16H,3-8H2,1-2H3,(H2,13,14) EHMN_ABBREVIATION: C04424
initial amount: NaN
boundary condition: false
has only substance units: false
type: Species
is: CHEBI:17577
name: S-(2-Methylpropanoyl)-dihydrolipoamide

metaR r1556
fast: false
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reversible: true
is described by: ECO:0000000
is: SBO:0000185
reactant: MODEL1310110061#
product: MODEL1310110061#
type: Reaction
kinetic law: MODEL1310110061#

http://identifiers.org/biomodels.db/MODEL1310110061#_96354851_86ab_4b8f_8de9_816aef249de8
boundary condition: true
initial concentration: NaN
has only substance units: false
is: SBO:0000252
name: NDUFS5
is encoded by: hsa:4725
type: Species
constant: false
is: Q6IBA0
initial amount: NaN

metaR 5HLTDL
modifier: MODEL1310110061#
reactant: MODEL1310110061#
type: Reaction
is version of: http://identifiers.org/ec-code/4.1.1.28
is described by: ECO:0000269
fast: false
name: 5-Hydroxy-L-tryptophan decarboxy-lyase
product: MODEL1310110061#
reversible: false
notes: GENE_ASSOCIATION: (1644.1) SUBSYSTEM: Tryptophan metabolism EC Number: 4.1.1.28 Confidence Level: 4 AUTHORS: PMID:1540578 NOTES:SAB
kinetic law: MODEL1310110061#
is: SBO:0000176

metaR r0666
type: Reaction
is: SBO:0000176
product: MODEL1310110061#
reactant: MODEL1310110061#
notes: GENE_ASSOCIATION: (4967.1) or (55753.1) SUBSYSTEM: Purine synthesis EC Number: 6.3.3.1 Confidence Level: 0 AUTHORS: PMID:4084560 NOTES:
is described by: ECO:0000000
modifier: MODEL1310110061#
fast: false
kinetic law: MODEL1310110061#
reversible: true
is version of: http://identifiers.org/ec-code/1.2.4.2
name: 2-(Formamido)-N1-(5-phosphoribosyl)acetamidine cyclo-ligase (ADP-forming) Purine metabolism EC:6.3.3.1

metaM n2m2nmn l
is: HMDB00742
has only substance units: false
name: reducing GlcNAc removed form of n2m2nmasn (w/o peptide)
is: SBO:0000247
notes: FORMULA: C50H84N4O36 CHARGE: 0
initial concentration: 1.0
constant: false
initial amount: NaN
type: Species
boundary condition: false
is: CHEBI:17588

metaM fprica c
has only substance units: false
initial amount: NaN
name: 5-Formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide
boundary condition: false
notes: FORMULA: C10H13N4O9P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC01344 EHMN_ABBREVIATION: C04734
constant: false
is: HMDB01439
type: Species
is: SBO:0000247
initial concentration: 1.0
is: C04734
is: CHEBI:58467

metaM rbt e
is: SBO:0000247
boundary condition: false
initial amount: NaN
is: HMDB00508
has only substance units: false
is: CHEBI:15963
type: Species
notes: FORMULA: C5H12O5 CHARGE: 0 INCHI: InChI=1S/C5H12O5/c6-1-3(8)5(10)4(9)2-7/h3-10H,1-2H2/t3-,4+,5- HEPATONET_1.0_ABBREVIATION: HC00380
name: D-ribitol
initial concentration: 1.0
constant: false

http://identifiers.org/biomodels.db/MODEL1310110061#_94b6e9ec_4424_47ab_8109_22c7abb16578
name: SLC1A4
is: P43007
is encoded by: hsa:6509
is: SBO:0000252
constant: false
boundary condition: true
initial amount: NaN
initial concentration: NaN
has only substance units: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110061#_92165eb1_a9fe_4408_92df_11ff93063ded
boundary condition: true
constant: false
has only substance units: false
initial concentration: NaN
is encoded by: hsa:AI620219
type: Species
name: _AI620219_1_c
initial amount: NaN
is: SBO:0000252

metaR HMGCOAtm
reactant: MODEL1310110061#
name: Hydroxymethylglutaryl-CoA reversible mitochondrial transport
reversible: true
product: MODEL1310110061#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: PMID:14713247 NOTES:NCD
is described by: ECO:0000000
is: SBO:0000185
type: Reaction
kinetic law: MODEL1310110061#
fast: false

metaR r1557
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
fast: false
reversible: true
kinetic law: MODEL1310110061#
product: MODEL1310110061#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reactant: MODEL1310110061#
is described by: ECO:0000000
type: Reaction

metaM urate c
name: Urate
initial amount: NaN
is: SBO:0000247
boundary condition: false
is: CHEBI:17775
constant: false
notes: FORMULA: C5H4N4O3 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00310 EHMN_ABBREVIATION: C00366
is: C00366
has only substance units: false
type: Species
initial concentration: 1.0
is: HMDB00289

http://identifiers.org/biomodels.db/MODEL1310110061#_cfb0b808_983a_4849_aaec_0de5af293a6f
is encoded by: hsa:51166
boundary condition: true
is: Q4W5N8
name: AADAT
is: SBO:0000252
type: Species
initial amount: NaN
constant: false
initial concentration: NaN
has only substance units: false

metaR r1662
product: MODEL1310110061#
kinetic law: MODEL1310110061#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
modifier: MODEL1310110061#
is described by: ECO:0000000
reactant: MODEL1310110061#
type: Reaction
fast: false
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reversible: true
is: SBO:0000185

metaM fucfucgalacglcgalgluside hs e
type: Species
is: C00095
constant: false
initial concentration: 1.0
initial amount: NaN
boundary condition: false
is: CHEBI:15824
is: SBO:0000247
name: Leb glycolipid
has only substance units: false
notes: FORMULA: C56H99N2O30FULLRCO CHARGE: 0
is: HMDB00660

metaM 3hexdtetcoa m
initial amount: NaN
name: 3,7,10,13-hexadecatetraenoylcoa
type: Species
is: HMDB02288
notes: FORMULA: C37H54N7O17P3S CHARGE: -4
has only substance units: false
constant: false
is: SBO:0000247
initial concentration: 1.0
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110061#_ae5ab973_6d73_40e4_89e0_97d82a355791
initial amount: NaN
has only substance units: false
initial concentration: NaN
is: SBO:0000252
boundary condition: true
is encoded by: hsa:27068
name: PPA2
constant: false
type: Species

metaR r2035
is: SBO:0000185
is described by: ECO:0000000
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.15
kinetic law: MODEL1310110061#
modifier: MODEL1310110061#
reversible: false
fast: false
reactant: MODEL1310110061#
product: MODEL1310110061#
type: Reaction
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:

metaR r1117
kinetic law: MODEL1310110061#
fast: false
type: Reaction
is: SBO:0000185
name: Facilitated diffusion
reactant: MODEL1310110061#
product: MODEL1310110061#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:17124168 NOTES:
is described by: ECO:0000000
reversible: true

metaR FUMm
modifier: MODEL1310110061#
reactant: MODEL1310110061#
notes: GENE_ASSOCIATION: (2271.1) SUBSYSTEM: Citric acid cycle EC Number: 4.2.1.2 Confidence Level: 0 AUTHORS: PMID:16774737,PMID:17111171,PMID:17111172 NOTES:IF. Biochemical
is described by: ECO:0000134
is version of: http://identifiers.org/ec-code/4.2.1.2
name: fumarase, mitochondrial
kinetic law: MODEL1310110061#
type: Reaction
fast: false
product: MODEL1310110061#
reversible: true
is: SBO:0000176

metaR r0178
modifier: MODEL1310110061#
kinetic law: MODEL1310110061#
name: Succinate-semialdehyde:NAD+ oxidoreductase Glutamate metabolism / Tyrosine metabolism / Butanoate metabolism EC:1.2.1.24 EC:1.2.1.16
notes: GENE_ASSOCIATION: (2222.1) SUBSYSTEM: Glutamate metabolism EC Number: 1.2.1.24 Confidence Level: 0 AUTHORS: PMID:3190233,PMID:656447,PMID:7616245,PMID:7814412 NOTES:
product: MODEL1310110061#
fast: false
is version of: http://identifiers.org/ec-code/2.5.1.21
reversible: true
reactant: MODEL1310110061#
is: SBO:0000176
type: Reaction
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110061#_872ada69_ce91_4465_85f6_9a86ea4c848c
constant: false
is encoded by: hsa:5052
initial amount: NaN
has only substance units: false
boundary condition: true
type: Species
is: SBO:0000252
initial concentration: NaN
name: PRDX1

http://identifiers.org/biomodels.db/MODEL1310110061#_f211686f_af4f_4132_92e5_5d1d08370fc2
is: P09622
has only substance units: false
is: SBO:0000252
constant: false
initial concentration: NaN
type: Species
is encoded by: hsa:1738
name: DLD
boundary condition: true
initial amount: NaN

metaR CGLYt3 2
type: Reaction
reactant: MODEL1310110061#
fast: false
product: MODEL1310110061#
modifier: MODEL1310110061#
kinetic law: MODEL1310110061#
is described by: ECO:0000304
notes: GENE_ASSOCIATION: (6565.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:12905028 NOTES:SAB
is: SBO:0000185
reversible: false
name: Cys-Gly transport in via proton symport

http://identifiers.org/biomodels.db/MODEL1310110061#_ba329471_06fb_4bed_aed5_0f653bc1fb70
is: SBO:0000252
type: Species
is encoded by: hsa:2531
constant: false
initial concentration: NaN
initial amount: NaN
name: KDSR
has only substance units: false
boundary condition: true
is: Q06136

http://identifiers.org/biomodels.db/MODEL1310110061#_a34d6a19_0cb2_448e_b0f4_def07da7e741
constant: false
is: Q8NFW8
initial concentration: NaN
is: SBO:0000252
name: CMAS
type: Species
boundary condition: true
is encoded by: hsa:55907
has only substance units: false
initial amount: NaN

metaR r0423
reversible: true
modifier: MODEL1310110061#
reactant: MODEL1310110061#
notes: GENE_ASSOCIATION: (AA081045.1) or (AI620219.1) or (219.1) or (217.1) or (224.1) or (501.1) or (223.1) or (AU149534.1) or (T83654.1) SUBSYSTEM: Unassigned EC Number: 1.1.1.42 Confidence Level: 0 AUTHORS: PMID:10521434,PMID:16489927,PMID:9866202 NOTES:
kinetic law: MODEL1310110061#
product: MODEL1310110061#
is version of: http://identifiers.org/ec-code/1.2.1.3
is described by: ECO:0000000
name: Isocitrate:NADP+ oxidoreductase (decarboxylating) Citrate cycle (TCA cycle) EC:1.1.1.42
type: Reaction
fast: false
is: SBO:0000176

metaR ASNtm
is: SBO:0000185
fast: false
reactant: MODEL1310110061#
kinetic law: MODEL1310110061#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: NOTES:TDV
reversible: false
product: MODEL1310110061#
is described by: ECO:0000000
name: L-asparagine transport, mitochondrial
type: Reaction

metaR GCHOLAte
fast: false
name: bile acid intracellular transport
is described by: ECO:0000000
is: SBO:0000185
product: MODEL1310110061#
reactant: MODEL1310110061#
kinetic law: MODEL1310110061#
type: Reaction
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:unknown mechanism, however bile acids need to be secreted out of the cell NJ

http://identifiers.org/biomodels.db/MODEL1310110061#_9f95fa7b_1733_42d9_b1a6_eea157eeb37f
initial amount: NaN
type: Species
is encoded by: hsa:8560
is: O15121
name: DEGS1
has only substance units: false
initial concentration: NaN
is: SBO:0000252
boundary condition: true
constant: false

metaR r0724
is: SBO:0000176
modifier: MODEL1310110061#
notes: GENE_ASSOCIATION: (AI924226.1) or (53354.1) or (80025.1) or (79646.1) or (55229.1) or (100128062.1) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.16 Confidence Level: 0 AUTHORS: PMID:1121274,PMID:1679347,PMID:3194209,PMID:6378901,PMID:8241273 NOTES:
reversible: true
kinetic law: MODEL1310110061#
is described by: ECO:0000000
type: Reaction
fast: false
product: MODEL1310110061#
is version of: http://identifiers.org/ec-code/2.7.1.33
name: Decanoyl-CoA:acetyl-CoA C-acyltransferase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:2.3.1.16
reactant: MODEL1310110061#

metaM oh1 e
boundary condition: false
is: C01328
constant: false
notes: FORMULA: HO CHARGE: -1
name: hydroxide ion
is: HMDB01039
is: SBO:0000247
initial concentration: 1.0
type: Species
has only substance units: false
initial amount: NaN

metaM lgnccoa c
name: lignocericyl coenzyme A
constant: false
is: HMDB06526
type: Species
initial concentration: 1.0
boundary condition: false
notes: FORMULA: C45H78N7O17P3S CHARGE: -4 INCHI: InChI=1/C45H82N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-24-25-36(54)73-29-28-47-35(53)26-27-48-43(57)40(56)45(2,3)31-66-72(63,64)69-71(61,62)65-30-34-39(68-70(58,59)60)38(55)44(67-34)52-33-51-37-41(46)49-32-50-42(37)52/h32-34,38-40,44,55-56H,4-31H2,1-3H3,(H,47,53)(H,48,57)(H,61,62)(H,63,64)(H2,46,49,50)(H2,58,59,60)/t34-,38?,39-,40+,44-/m1/s1
is: SBO:0000247
has only substance units: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110061#_160539d1_7a93_4504_bb19_48a03c9528b2
is encoded by: hsa:5742
boundary condition: true
is: SBO:0000252
has only substance units: false
initial amount: NaN
name: PTGS1
is: P23219
constant: false
initial concentration: NaN
type: Species

http://identifiers.org/biomodels.db/MODEL1310110061#_41e3cda0_f98e_434b_9c97_e8c5ed5f38aa
type: Species
name: TK2
is: O00142
boundary condition: true
is encoded by: hsa:7084
initial concentration: NaN
initial amount: NaN
constant: false
is: SBO:0000252
has only substance units: false

metaM HC02175 c
initial concentration: 1.0
name: caprate
initial amount: NaN
boundary condition: false
is: SBO:0000247
is: CHEBI:27689
has only substance units: false
notes: FORMULA: C10H19O2 CHARGE: -1 INCHI: InChI=1S/C10H20O2/c1-2-3-4-5-6-7-8-9-10(11)12/h2-9H2,1H3,(H,11,12)/p-1
constant: false
type: Species

metaM trdrd c
has only substance units: false
initial concentration: 1.0
is: SBO:0000247
name: Reduced thioredoxin
is: CHEBI:15967
constant: false
boundary condition: false
type: Species
notes: FORMULA: XH2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00289 EHMN_ABBREVIATION: C00342
is: C00342
initial amount: NaN

metaM CE5161 r
initial amount: NaN
name: 3(S)-hydroxy-cis-9-octadecenoyl-CoA
is: HMDB01509
constant: false
boundary condition: false
notes: FORMULA: C39H64N7O18P3S CHARGE: -4 INCHI: InChI=1/C39H68N7O18P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-27(47)22-30(49)68-21-20-41-29(48)18-19-42-37(52)34(51)39(2,3)24-61-67(58,59)64-66(56,57)60-23-28-33(63-65(53,54)55)32(50)38(62-28)46-26-45-31-35(40)43-25-44-36(31)46/h11-12,25-28,32-34,38,47,50-51H,4-10,13-24H2,1-3H3,(H,41,48)(H,42,52)(H,56,57)(H,58,59)(H2,40,43,44)(H2,53,54,55)/p-4/b12-11-/t27-,28-,32+,33+,34u,38-/m0/s1 EHMN_ABBREVIATION: CE5161
is: CHEBI:57460
is: SBO:0000247
type: Species
initial concentration: 1.0
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110061#_a4790fd9_c82f_4fd7_aca3_1ec87826ac6b
initial amount: NaN
type: Species
is encoded by: hsa:55229
constant: false
is: Q9NVE7
name: PANK4
is: SBO:0000252
has only substance units: false
initial concentration: NaN
boundary condition: true

metaR 2OXOADOXm
is: SBO:0000176
type: Reaction
modifier: MODEL1310110061#
fast: false
reversible: false
notes: GENE_ASSOCIATION: (4967.1) and (1738.1 and 8050.1) and (1743.1) or (4967.2) and (1738.1 and 8050.1) and (1743.1) SUBSYSTEM: Lysine metabolism EC Number: 2.3.1.61 Confidence Level: 2 AUTHORS: NOTES:SAB
kinetic law: MODEL1310110061#
is version of: http://identifiers.org/ec-code/2.3.1.61
reactant: MODEL1310110061#
is version of: http://identifiers.org/ec-code/1.8.1.4
is described by: ECO:0000304
product: MODEL1310110061#
is version of: http://identifiers.org/ec-code/1.2.4.2
name: 2-Oxoadipate:lipoamde 2-oxidoreductase(decarboxylating and acceptor-succinylating) (mitochondria)

metaR r1116
type: Reaction
name: ATP Exporter (ATP-E) TCDB:9.A.6.1.1
is described by: ECO:0000000
reactant: MODEL1310110061#
kinetic law: MODEL1310110061#
is: SBO:0000185
product: MODEL1310110061#
fast: false
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:10913128,PMID:11147574,PMID:11557556,PMID:12269403,PMID:14613890,PMID:15210701,PMID:15958381,PMID:17124168,PMID:179827,PMID:18697206,PMID:3031070,PMID:3244197,PMID:9305892 NOTES:

metaR PItg
name: phosphate transport, Golgi apparatus
kinetic law: MODEL1310110061#
is: SBO:0000185
fast: false
reactant: MODEL1310110061#
reversible: false
product: MODEL1310110061#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 2 AUTHORS: NOTES:NCD
is described by: ECO:0000000
type: Reaction

metaR r2036
kinetic law: MODEL1310110061#
reactant: MODEL1310110061#
product: MODEL1310110061#
is: SBO:0000185
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.15
type: Reaction
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
modifier: MODEL1310110061#
reversible: false
fast: false
is described by: ECO:0000000

metaR SPMTDe
type: Reaction
is described by: ECO:0000134
product: MODEL1310110061#
reversible: true
is: SBO:0000185
kinetic law: MODEL1310110061#
reactant: MODEL1310110061#
fast: false
name: SPMTDe
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:

metaR r0179
name: Succinate-semialdehyde:NADP+ oxidoreductase Glutamate metabolism / Tyrosine metabolism / Butanoate metabolism EC:1.2.1.16
product: MODEL1310110061#
is version of: http://identifiers.org/ec-code/1.1.1.27
notes: GENE_ASSOCIATION: (AI656480.1) or (BE042354.1) or (3939.1) or (92483.1) or (3945.1) or (3948.1) SUBSYSTEM: Glutamate metabolism EC Number: 1.2.1.16 Confidence Level: 0 AUTHORS: PMID:4066712,PMID:7814412 NOTES:
reversible: true
reactant: MODEL1310110061#
modifier: MODEL1310110061#
is: SBO:0000176
is described by: ECO:0000000
type: Reaction
fast: false
kinetic law: MODEL1310110061#

http://identifiers.org/biomodels.db/MODEL1310110061#_d5b79b32_64b5_405b_8842_cdc70d3a2493
has only substance units: false
is: P36969
initial amount: NaN
boundary condition: true
name: GPX4
type: Species
is encoded by: hsa:2879
constant: false
initial concentration: NaN
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110061#_fe0f98e7_d6cf_46ba_aacd_756cd716ca03
initial amount: NaN
initial concentration: NaN
name: HADHB
is: SBO:0000252
is: P55084
type: Species
has only substance units: false
constant: false
is encoded by: hsa:3032
boundary condition: true

metaR CYTK14n
modifier: MODEL1310110061#
name: cytidylate kinase (dCMP,CTP),nuclear
is version of: http://identifiers.org/ec-code/2.7.4.14
type: Reaction
is: SBO:0000176
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
reactant: MODEL1310110061#
is described by: ECO:0000269
kinetic law: MODEL1310110061#
reversible: true
product: MODEL1310110061#
fast: false

http://identifiers.org/biomodels.db/MODEL1310110061#_3e0dde4e_014b_4bf7_874e_52df16b0a304
is: Q8N142
is: SBO:0000252
has only substance units: false
is encoded by: hsa:122622
initial concentration: NaN
initial amount: NaN
boundary condition: true
constant: false
type: Species
name: ADSSL1

metaM lnlncg l
boundary condition: false
initial amount: NaN
notes: FORMULA: C18H29O2 CHARGE: -1 INCHI: InChI=1S/C18H30O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20/h6-7,9-10,12-13H,2-5,8,11,14-17H2,1H3,(H,19,20)/p-1/b7-6-,10-9-,13-12- HEPATONET_1.0_ABBREVIATION: HC01757 EHMN_ABBREVIATION: C06426
is: CHEBI:32391
initial concentration: 1.0
has only substance units: false
type: Species
is: SBO:0000247
constant: false
name: gamma-linolenate
is: HMDB03073

metaM lnlnca e
constant: false
has only substance units: false
is: CHEBI:32387
initial concentration: 1.0
initial amount: NaN
boundary condition: false
name: alpha-linolenate
type: Species
is: SBO:0000247
is: HMDB01388
notes: FORMULA: C18H29O2 CHARGE: -1 INCHI: InChI=1S/C18H30O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20/h3-4,6-7,9-10H,2,5,8,11-17H2,1H3,(H,19,20)/p-1/b4-3-,7-6-,10-9-

metaR CLPNDt
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11788354,PMID:12864740 NOTES:NJ
reactant: MODEL1310110061#
is: SBO:0000185
type: Reaction
reversible: true
name: fatty acid transport via diffusion
product: MODEL1310110061#
kinetic law: MODEL1310110061#
is described by: ECO:0000000
fast: false

http://identifiers.org/biomodels.db/MODEL1310110061#_8c7051fe_7e8e_4d8f_a2fb_269b42547971
boundary condition: true
name: _AV713053_1_m
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:AV713053
has only substance units: false
constant: false
is: SBO:0000252
type: Species

metaM ppi e
has only substance units: false
notes: FORMULA: HO7P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00023 EHMN_ABBREVIATION: C00013
type: Species
constant: false
is: C00013
is: SBO:0000247
initial concentration: 1.0
boundary condition: false
is: HMDB00250
initial amount: NaN
is: CHEBI:33019
name: Diphosphate

metaR CO2ter
reactant: MODEL1310110061#
reversible: true
kinetic law: MODEL1310110061#
fast: false
name: CO2 endoplasmic reticular transport via diffusion
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD
is described by: ECO:0000000
type: Reaction
product: MODEL1310110061#
is: SBO:0000185

metaR EX spmd LPAREN e RPAREN
kinetic law: MODEL1310110061#
reactant: MODEL1310110061#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of spermidine(3+)
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110061#_eb25bc51_9eed_4fff_8920_6f8d17f7ef8d
has only substance units: false
initial concentration: NaN
is: SBO:0000252
constant: false
name: SLC5A3
is: P53794
type: Species
initial amount: NaN
is encoded by: hsa:6526
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110061#_0d438bad_88ec_4740_baf1_3ff9bca09381
is: SBO:0000297
constant: false
type: Species
has part: Q96CA6
has only substance units: false
initial amount: NaN
name: ACAA1:HSD17B4:ACOX1
has part: E9PB82
is encoded by: hsa:30
boundary condition: true
is encoded by: hsa:3295
has part: B4DK61
initial concentration: NaN
is encoded by: hsa:51

http://identifiers.org/biomodels.db/MODEL1310110061#_067f0a5c_372d_4a90_8166_cd19bd3eaebc
type: Species
initial concentration: NaN
is encoded by: hsa:4048
boundary condition: true
constant: false
name: LTA4H
is: SBO:0000252
initial amount: NaN
is: P09960
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110061#_c48fb230_02a3_40fb_8980_58e6655e407d
initial concentration: NaN
is: E7EPT3
has only substance units: false
is encoded by: hsa:501
name: ALDH7A1
boundary condition: true
constant: false
type: Species
is: SBO:0000252
initial amount: NaN

metaR EX mag hs LPAREN e RPAREN
kinetic law: MODEL1310110061#
reactant: MODEL1310110061#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Monoacylglycerol 2 (homo sapiens) exchange
type: Reaction

metaR RE3241R
product: MODEL1310110061#
is: SBO:0000176
kinetic law: MODEL1310110061#
name: RE3241
reversible: false
type: Reaction
fast: false
is described by: ECO:0000000
modifier: MODEL1310110061#
notes: GENE_ASSOCIATION: (64834.1) SUBSYSTEM: Fatty acid synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:10970790 NOTES:
reactant: MODEL1310110061#

metaR RE1521M
notes: GENE_ASSOCIATION: (1892.1) or (3030.1) or (1962.1) or (3032.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.17 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:7923814,PMID:9568246,PMID:9920399 NOTES:
is version of: http://identifiers.org/ec-code/4.2.1.17
fast: false
kinetic law: MODEL1310110061#
type: Reaction
is: SBO:0000176
reversible: true
is version of: http://identifiers.org/ec-code/2.3.1.16
modifier: MODEL1310110061#
reactant: MODEL1310110061#
is described by: ECO:0000000
name: RE1521
is version of: http://identifiers.org/ec-code/1.1.1.35
product: MODEL1310110061#

http://identifiers.org/biomodels.db/MODEL1310110061#_642379a0_99b2_452a_baae_a94b01f03e6f
type: Species
is: P28332
initial amount: NaN
is encoded by: hsa:130
initial concentration: NaN
boundary condition: true
name: ADH6
has only substance units: false
is: SBO:0000252
constant: false

metaR r0722
modifier: MODEL1310110061#
name: (S)-3-Hydroxydodecanoyl-CoA:NAD+ oxidoreductase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:1.1.1.35 EC:1.1.1.211
reversible: true
product: MODEL1310110061#
is: SBO:0000176
kinetic law: MODEL1310110061#
fast: false
notes: GENE_ASSOCIATION: (5805.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.1.1.35 Confidence Level: 0 AUTHORS: PMID:10231530,PMID:10329704,PMID:1550553,PMID:1651711,PMID:7150615,PMID:8188243,PMID:8687463,PMID:9553139 NOTES:
is described by: ECO:0000000
type: Reaction
is version of: http://identifiers.org/ec-code/4.2.3.12
reactant: MODEL1310110061#

http://identifiers.org/biomodels.db/MODEL1310110061#_95631269_a1a7_4f2a_b30f_ba8c55994096
type: Species
boundary condition: true
initial amount: NaN
initial concentration: NaN
name: LSS
is: SBO:0000252
has only substance units: false
constant: false
is encoded by: hsa:4047
is: E9PEI9

metaM HC02121 c
initial amount: NaN
type: Species
is: SBO:0000247
notes: FORMULA: C11H18N3O7S CHARGE: -1 INCHI: InChI=1S/C11H19N3O7S/c12-6(11(20)21)1-2-8(16)14-7(4-22-5-15)10(19)13-3-9(17)18/h6-7,15H,1-5,12H2,(H,13,19)(H,14,16)(H,17,18)(H,20,21)/p-1/t6-,7-/m0/s1 EHMN_ABBREVIATION: C14180
has only substance units: false
name: S-(hydroxymethyl)glutathione(1-)
is: CHEBI:58758
constant: false
boundary condition: false
initial concentration: 1.0

metaM cmpacna g
boundary condition: false
is: CHEBI:57812
initial concentration: 1.0
type: Species
notes: FORMULA: C20H29N4O16P CHARGE: -2 INCHI: InChI=1S/C20H31N4O16P/c1-7(26)22-12-8(27)4-20(18(32)33,39-16(12)13(29)9(28)5-25)40-41(35,36)37-6-10-14(30)15(31)17(38-10)24-3-2-11(21)23-19(24)34/h2-3,8-10,12-17,25,27-31H,4-6H2,1H3,(H,22,26)(H,32,33)(H,35,36)(H2,21,23,34)/p-2/t8-,9+,10+,12+,13+,14+,15+,16+,17+,20+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00126 EHMN_ABBREVIATION: C00128
is: HMDB01176
initial amount: NaN
name: CMP-N-acetyl-beta-neuraminate(2-)
is: SBO:0000247
has only substance units: false
constant: false

http://identifiers.org/biomodels.db/MODEL1310110061#_0999105f_7885_4c7a_a096_f20adbe5d87e
is: SBO:0000252
name: ALDH9A1
boundary condition: true
constant: false
is encoded by: hsa:223
type: Species
is: P49189
initial concentration: NaN
has only substance units: false
initial amount: NaN

metaM oh1 c
is: HMDB01039
is: SBO:0000247
initial amount: NaN
has only substance units: false
type: Species
is: C01328
boundary condition: false
name: hydroxide ion
initial concentration: 1.0
notes: FORMULA: HO CHARGE: -1
constant: false

metaM pail34p hs c
is: CHEBI:57658
type: Species
initial amount: NaN
is: SBO:0000247
constant: false
initial concentration: 1.0
name: 1-phosphatidyl-1D-myo-inositol 3,4-bisphosphate(5-)
boundary condition: false
has only substance units: false
notes: FORMULA: C9H14O15P3FULLRCO2FULLR2CO2 CHARGE: -5

metaM lnlncgcoa r
has only substance units: false
initial concentration: 1.0
is: HMDB06368
name: gamma-linolenoyl-CoA(4-)
is: CHEBI:57363
initial amount: NaN
is: SBO:0000247
type: Species
notes: FORMULA: C39H60N7O17P3S CHARGE: -4 INCHI: InChI=1S/C39H64N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-30(48)67-23-22-41-29(47)20-21-42-37(51)34(50)39(2,3)25-60-66(57,58)63-65(55,56)59-24-28-33(62-64(52,53)54)32(49)38(61-28)46-27-45-31-35(40)43-26-44-36(31)46/h8-9,11-12,14-15,26-28,32-34,38,49-50H,4-7,10,13,16-25H2,1-3H3,(H,41,47)(H,42,51)(H,55,56)(H,57,58)(H2,40,43,44)(H2,52,53,54)/p-4/b9-8-,12-11-,15-14-/t28-,32-,33-,34+,38-/m1/s1 EHMN_ABBREVIATION: C03035
constant: false
boundary condition: false

metaM dolglcp L r
is: SBO:0000247
name: Dolichyl beta-D-glucosyl phosphate, human liver homolog
has only substance units: false
notes: FORMULA: C1140H1868O90P10 CHARGE: -10 INCHI: InChI=1S/C31H55O9P/c1-22(2)11-7-12-23(3)13-8-14-24(4)15-9-16-25(5)17-10-18-26(6)19-20-38-41(36,37)40-31-30(35)29(34)28(33)27(21-32)39-31/h11,13,15,17,26-35H,7-10,12,14,16,18-21H2,1-6H3,(H,36,37)/b23-13+,24-15+,25-17-/t26?,27-,28-,29+,30-,31+/m1/s1
initial concentration: 1.0
boundary condition: false
initial amount: NaN
constant: false
type: Species
is: CHEBI:15812

http://identifiers.org/biomodels.db/MODEL1310110061#_a0c4080a_10df_4e54_8357_a09ccb201bf3
is encoded by: hsa:145226
is: SBO:0000252
initial concentration: NaN
type: Species
has only substance units: false
constant: false
boundary condition: true
is: Q96NR8
name: RDH12
initial amount: NaN

metaR r0426
fast: false
reversible: true
name: isocitrate hydro-lyase Citrate cycle (TCA cycle) / Glyoxylate and dicarboxylate metabolism EC:4.2.1.3
notes: GENE_ASSOCIATION: (5860.1) SUBSYSTEM: Unassigned EC Number: 4.2.1.3 Confidence Level: 0 AUTHORS: PMID:15263083,PMID:16511074 NOTES:
reactant: MODEL1310110061#
is version of: http://identifiers.org/ec-code/1.5.1.34
product: MODEL1310110061#
modifier: MODEL1310110061#
is described by: ECO:0000000
type: Reaction
is: SBO:0000176
kinetic law: MODEL1310110061#

metaR ACCOAtn
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD
reactant: MODEL1310110061#
type: Reaction
product: MODEL1310110061#
reversible: true
fast: false
name: acetyl-CoA transport, nuclear
is described by: ECO:0000000
is: SBO:0000185
kinetic law: MODEL1310110061#

metaR EX ump LPAREN e RPAREN
kinetic law: MODEL1310110061#
reactant: MODEL1310110061#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: UMP exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110061#_31a10736_1cef_47ef_b6f0_9549991c95dc
constant: false
boundary condition: true
is: P48736
name: PIK3CG
initial concentration: NaN
type: Species
initial amount: NaN
has only substance units: false
is: SBO:0000252
is encoded by: hsa:5294

http://identifiers.org/biomodels.db/MODEL1310110061#_2db9d4d2_9279_4305_9b64_f7f8a4fb4ab6
constant: false
has only substance units: false
is: Q53HM1
is encoded by: hsa:54963
type: Species
is: SBO:0000252
initial amount: NaN
name: UCKL1
initial concentration: NaN
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110061#_2250f6ef_271d_468d_b523_b8e6bc667617
name: OXCT1
initial concentration: NaN
constant: false
is: P55809
type: Species
has only substance units: false
initial amount: NaN
boundary condition: true
is: SBO:0000252
is encoded by: hsa:5019

http://identifiers.org/biomodels.db/MODEL1310110061#_60be0de6_6b1e_4fca_8ee0_7c3cfdb224b0
initial concentration: NaN
name: ATG9B
is: Q674R7
initial amount: NaN
is encoded by: hsa:285973
type: Species
constant: false
is: SBO:0000252
boundary condition: true
has only substance units: false

metaR NRVNCCOAtxc
kinetic law: MODEL1310110061#
product: MODEL1310110061#
reactant: MODEL1310110061#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of nervonylcoa into peroxisomes
type: Reaction

metaR INSTt4 2
modifier: MODEL1310110061#
type: Reaction
notes: GENE_ASSOCIATION: (115584.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12039040,PMID:12133831 NOTES:NCD
is described by: ECO:0000006
reactant: MODEL1310110061#
product: MODEL1310110061#
kinetic law: MODEL1310110061#
fast: false
reversible: true
is: SBO:0000185
name: inositol transport via sodium symport

metaR BTNDe
is: SBO:0000176
type: Reaction
modifier: MODEL1310110061#
is version of: http://identifiers.org/ec-code/3.5.1.12
notes: GENE_ASSOCIATION: (686.1) SUBSYSTEM: Biotin metabolism EC Number: 3.5.1.12 Confidence Level: 4 AUTHORS: PMID:12459313,PMID:7509806,PMID:8001986 NOTES:Also acts on biotin esters IT
is described by: ECO:0000269
reversible: false
name: biotinidase (biotin), extracellular
fast: false
reactant: MODEL1310110061#
product: MODEL1310110061#
kinetic law: MODEL1310110061#

http://identifiers.org/biomodels.db/MODEL1310110061#_4603f862_4854_4eec_87f0_511c8007e531
has only substance units: false
initial amount: NaN
is: Q6ZMR3
is: SBO:0000252
is encoded by: hsa:160287
boundary condition: true
initial concentration: NaN
type: Species
name: LDHAL6A
constant: false

metaM ocdca e
has only substance units: false
boundary condition: false
is: SBO:0000247
is: CHEBI:25629
name: octadecanoate (n-C18:0)
initial concentration: 1.0
type: Species
initial amount: NaN
is: C01530
notes: FORMULA: C18H35O2 CHARGE: -1 EHMN_ABBREVIATION: C01530
is: HMDB00827
constant: false

http://identifiers.org/biomodels.db/MODEL1310110061#_418a4cce_bc1e_49cc_888d_8569fb590714
name: TM7SF2
is encoded by: hsa:7108
has only substance units: false
constant: false
initial concentration: NaN
initial amount: NaN
is: O76062
is: SBO:0000252
type: Species
boundary condition: true

metaM ppi c
type: Species
is: C00013
initial concentration: 1.0
constant: false
boundary condition: false
is: SBO:0000247
is: HMDB00250
is: CHEBI:0
name: Diphosphate
initial amount: NaN
has only substance units: false
notes: FORMULA: HO7P2 CHARGE: -3

metaR EX ppi LPAREN e RPAREN
kinetic law: MODEL1310110061#
reactant: MODEL1310110061#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for ppi
type: Reaction

metaR EX h LPAREN e RPAREN
kinetic law: MODEL1310110061#
reactant: MODEL1310110061#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for proton
type: Reaction

metaR ADK3
name: adentylate kinase (GTP)
product: MODEL1310110061#
reactant: MODEL1310110061#
type: Reaction
is described by: ECO:0000269
fast: false
modifier: MODEL1310110061#
is: SBO:0000176
notes: GENE_ASSOCIATION: (26289.1) or (26289.2) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: PMID:9434148 NOTES:JLR
reversible: true
is version of: http://identifiers.org/ec-code/2.7.4.3
kinetic law: MODEL1310110061#

metaR XYLTt
type: Reaction
is described by: ECO:0000000
kinetic law: MODEL1310110061#
reactant: MODEL1310110061#
fast: false
is: SBO:0000185
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 1 AUTHORS: PMID:6821187 NOTES:NCD
name: Xylitol transport via passive diffusion
product: MODEL1310110061#

metaR TRIODTHYt2
fast: false
kinetic law: MODEL1310110061#
modifier: MODEL1310110061#
product: MODEL1310110061#
name: T3 transport via facilitated diffusion
reversible: true
type: Reaction
reactant: MODEL1310110061#
notes: GENE_ASSOCIATION: (6567.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12871948,PMID:7981683 NOTES:NJ
is: SBO:0000185
is described by: ECO:0000269

http://identifiers.org/biomodels.db/MODEL1310110061#_0c434b31_c2b8_447a_bbdf_a77255d516bb
is encoded by: hsa:6553
type: Species
initial amount: NaN
boundary condition: true
constant: false
name: SLC9A5
has only substance units: false
is: Q9NSW9
initial concentration: NaN
is: SBO:0000252

metaM HC01602 c
is: CHEBI:57454
has only substance units: false
boundary condition: false
initial concentration: 1.0
initial amount: NaN
notes: FORMULA: C20H21N7O7 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00212 EHMN_ABBREVIATION: C00234
is: C00234
type: Species
name: 10-Formyltetrahydrofolate
is: SBO:0000247
constant: false

metaM dopa c
type: Species
initial amount: NaN
is: CHEBI:59905
initial concentration: 1.0
name: dopaminium(1+)
is: HMDB00073
boundary condition: false
is: SBO:0000247
notes: FORMULA: C8H12NO2 CHARGE: 1 INCHI: InChI=1S/C8H11NO2/c9-4-3-6-1-2-7(10)8(11)5-6/h1-2,5,10-11H,3-4,9H2/p+1 HEPATONET_1.0_ABBREVIATION: HC01175 EHMN_ABBREVIATION: C03758
constant: false
has only substance units: false

metaR r0509
fast: false
is: SBO:0000176
kinetic law: MODEL1310110061#
notes: GENE_ASSOCIATION: SUBSYSTEM: Citric acid cycle EC Number: 1.3.5.1 Confidence Level: 0 AUTHORS: PMID:2843227 NOTES:
is described by: ECO:0000000
name: Succinate:ubiquinone oxidoreductase Citrate cycle (TCA cycle) EC:1.3.5.1
reactant: MODEL1310110061#
reversible: false
product: MODEL1310110061#
type: Reaction

metaR AHEXASE2ly
is: SBO:0000176
reactant: MODEL1310110061#
is version of: http://identifiers.org/ec-code/3.2.1.52
is described by: ECO:0000000
modifier: MODEL1310110061#
fast: false
kinetic law: MODEL1310110061#
reversible: false
type: Reaction
name: beta-N-acetylhexosaminidase, lysosomal
product: MODEL1310110061#
notes: GENE_ASSOCIATION: (3074.1) or (3073.1) or (3073.1 and 3074.1) SUBSYSTEM: N-glycan degradation EC Number: 3.2.1.52 Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12706724 NOTES:NCD

http://identifiers.org/biomodels.db/MODEL1310110061#_d6cfd62b_9af8_4099_aa70_d709959823ad
is: SBO:0000252
initial amount: NaN
has only substance units: false
type: Species
initial concentration: NaN
boundary condition: true
is encoded by: hsa:1375
name: CPT1B
is: Q92523
constant: false

http://identifiers.org/biomodels.db/MODEL1310110061#_1ff02338_ddca_4ad3_bfef_674ce78d63d8
boundary condition: true
initial concentration: NaN
constant: false
type: Species
initial amount: NaN
is encoded by: hsa:3037
has only substance units: false
is: SBO:0000252
name: HAS2
is: Q92819

metaR r1446
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 1.3.3.6 Confidence Level: 0 AUTHORS: PMID:17603022,PMID:1774065,PMID:3597357,PMID:6240978,PMID:7876265 NOTES:
is: SBO:0000176
reversible: false
kinetic law: MODEL1310110061#
reactant: MODEL1310110061#
type: Reaction
product: MODEL1310110061#
name: EC:1.3.3.6
is described by: ECO:0000000

metaR ECOAH9m
modifier: MODEL1310110061#
is: SBO:0000176
product: MODEL1310110061#
fast: false
is described by: ECO:0000304
is version of: http://identifiers.org/ec-code/2.3.1.16
notes: GENE_ASSOCIATION: (1892.1) or (3030.1) and (3032.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 4.2.1.17 Confidence Level: 2 AUTHORS: PMID:9073515 NOTES:MM. based on assigned short chain enoyl-CoA hydratase activity
reactant: MODEL1310110061#
type: Reaction
kinetic law: MODEL1310110061#
name: 2-Methylprop-2-enoyl-CoA (2-Methylbut-2-enoyl-CoA), mitochondrial
is version of: http://identifiers.org/ec-code/4.2.1.17
reversible: true

metaR r1177
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 3.1.1.13 Confidence Level: 0 AUTHORS: PMID:11230747,PMID:8112342 NOTES:
product: MODEL1310110061#
kinetic law: MODEL1310110061#
name: EC:3.1.1.13
is: SBO:0000176
type: Reaction
reactant: MODEL1310110061#
reversible: false
fast: false
is described by: ECO:0000000

metaR UMPK6n
kinetic law: MODEL1310110061#
fast: false
is: SBO:0000176
product: MODEL1310110061#
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
reactant: MODEL1310110061#
type: Reaction
name: UMP kinase (dCTP),nuclear
modifier: MODEL1310110061#
reversible: true
is version of: http://identifiers.org/ec-code/2.7.4.14

metaR DNDPt14m
kinetic law: MODEL1310110061#
is described by: ECO:0000269
modifier: MODEL1310110061#
name: dUDP transport via dTDP antiport
is: SBO:0000185
product: MODEL1310110061#
reactant: MODEL1310110061#
fast: false
reversible: false
notes: GENE_ASSOCIATION: (60386.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:11226231 NOTES:IT
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110061#_ab84df4b_e04e_43f9_8c64_2bd5bf1b10de
is: P31350
type: Species
initial concentration: NaN
constant: false
is: SBO:0000252
has only substance units: false
is encoded by: hsa:6241
boundary condition: true
name: RRM2
initial amount: NaN

metaM ocdca c
boundary condition: false
is: HMDB00827
constant: false
notes: FORMULA: C18H35O2 CHARGE: -1 INCHI: InChI=1S/C18H36O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20/h2-17H2,1H3,(H,19,20)/p-1 EHMN_ABBREVIATION: C01530
initial concentration: 1.0
is: SBO:0000247
is: CHEBI:25629
name: stearate
type: Species
initial amount: NaN
has only substance units: false

metaR FAOXC164GC163m
kinetic law: MODEL1310110061#
product: MODEL1310110061#
reactant: MODEL1310110061#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C16:4-->C16:3)gm
type: Reaction

metaR 34HPPte
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
kinetic law: MODEL1310110061#
reactant: MODEL1310110061#
reversible: true
is described by: ECO:0000134
name: Transport of 3-(4-hydroxyphenyl)pyruvate
fast: false
type: Reaction
product: MODEL1310110061#

metaR NADS2
modifier: MODEL1310110061#
notes: GENE_ASSOCIATION: (55191.1) SUBSYSTEM: NAD metabolism EC Number: Confidence Level: 4 AUTHORS: NOTES:
type: Reaction
reactant: MODEL1310110061#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/6.3.5.1
is described by: ECO:0000269
kinetic law: MODEL1310110061#
fast: false
product: MODEL1310110061#
name: NAD synthase (glutamine-hydrolysing)
reversible: false

metaR FAS140COA
is: SBO:0000176
reversible: false
notes: GENE_ASSOCIATION: (2194.1) SUBSYSTEM: Fatty acid synthesis EC Number: 2.3.1.86 Confidence Level: 4 AUTHORS: PMID:11756679,PMID:15507492,PMID:2669958 NOTES:NCD
fast: false
reactant: MODEL1310110061#
product: MODEL1310110061#
type: Reaction
kinetic law: MODEL1310110061#
is version of: http://identifiers.org/ec-code/2.3.1.85
name: fatty-acyl-CoA synthase (n-C14:0CoA)
modifier: MODEL1310110061#
is described by: ECO:0000269

metaR CLS hs
product: MODEL1310110061#
reactant: MODEL1310110061#
fast: false
type: Reaction
modifier: MODEL1310110061#
notes: GENE_ASSOCIATION: (54675.1) SUBSYSTEM: Glycerophospholipid metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:10799718 NOTES:NJ
is: SBO:0000176
reversible: false
is described by: ECO:0000000
name: cardiolipin synthase (homo sapiens)
kinetic law: MODEL1310110061#

http://identifiers.org/biomodels.db/MODEL1310110061#_bd03928a_b490_4e43_8daf_defd5ff0273d
is encoded by: hsa:64064
name: OXCT2
boundary condition: true
is: Q9BYC2
is: SBO:0000252
type: Species
has only substance units: false
initial amount: NaN
constant: false
initial concentration: NaN

metaR HBZOPT10m
name: Hydroxybenzoate Decaprenyltransferase
reversible: false
notes: GENE_ASSOCIATION: (27235.1) SUBSYSTEM: Ubiquinone synthesis EC Number: Confidence Level: 4 AUTHORS: PMID:15153069,PMID:1965190,PMID:7380842 NOTES:Used to make Ubiquinone-10 EC 2.5.1.- IT
reactant: MODEL1310110061#
is described by: ECO:0000269
fast: false
kinetic law: MODEL1310110061#
modifier: MODEL1310110061#
is version of: http://identifiers.org/ec-code/2.5.1.39
product: MODEL1310110061#
is: SBO:0000176
type: Reaction

metaR ADK1
reversible: true
modifier: MODEL1310110061#
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/2.7.4.3
reactant: MODEL1310110061#
name: adenylate kinase
type: Reaction
product: MODEL1310110061#
kinetic law: MODEL1310110061#
is: SBO:0000176
notes: GENE_ASSOCIATION: (122481.1) or (203.1) or (26289.1) or (26289.2) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: NOTES:
fast: false

metaR DM taur LPAREN c RPAREN
kinetic law: MODEL1310110061#
reactant: MODEL1310110061#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: demand reaction for taurine
type: Reaction

metaM CE2250 e
initial amount: NaN
has only substance units: false
boundary condition: false
name: 3-oxodocosanoyl-CoA
is: SBO:0000247
constant: false
type: Species
initial concentration: 1.0
notes: FORMULA: C43H72N7O18P3S CHARGE: -4 INCHI: InChI=1S/C43H76N7O18P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-31(51)26-34(53)72-25-24-45-33(52)22-23-46-41(56)38(55)43(2,3)28-65-71(62,63)68-70(60,61)64-27-32-37(67-69(57,58)59)36(54)42(66-32)50-30-49-35-39(44)47-29-48-40(35)50/h29-30,32,36-38,42,54-55H,4-28H2,1-3H3,(H,45,52)(H,46,56)(H,60,61)(H,62,63)(H2,44,47,48)(H2,57,58,59)/t32-,36-,37-,38+,42-/m1/s1 EHMN_ABBREVIATION: CE2250
is: CHEBI:52328

metaR PItn
reversible: true
is described by: ECO:0000000
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: NOTES:IT
product: MODEL1310110061#
is: SBO:0000185
kinetic law: MODEL1310110061#
reactant: MODEL1310110061#
name: phosphate transport, nuclear
type: Reaction

metaM cmpacna c
has only substance units: false
type: Species
boundary condition: false
notes: FORMULA: C20H29N4O16P CHARGE: -2 INCHI: InChI=1S/C20H31N4O16P/c1-7(26)22-12-8(27)4-20(18(32)33,39-16(12)13(29)9(28)5-25)40-41(35,36)37-6-10-14(30)15(31)17(38-10)24-3-2-11(21)23-19(24)34/h2-3,8-10,12-17,25,27-31H,4-6H2,1H3,(H,22,26)(H,32,33)(H,35,36)(H2,21,23,34)/p-2/t8-,9+,10+,12+,13+,14+,15+,16+,17+,20+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00126 EHMN_ABBREVIATION: C00128
name: CMP-N-acetyl-beta-neuraminate(2-)
is: SBO:0000247
is: HMDB01176
is: CHEBI:57812
initial concentration: 1.0
constant: false
initial amount: NaN

metaR ICDHyrm
kinetic law: MODEL1310110061#
notes: GENE_ASSOCIATION: (3418.1) SUBSYSTEM: Citric acid cycle EC Number: 1.1.1.42 Confidence Level: 4 AUTHORS: PMID:12234803,PMID:8187868 NOTES:The reaction may be reversible. Strathern shows the reaction as irreversible. IF
product: MODEL1310110061#
type: Reaction
name: Isocitrate dehydrogenase (NADP+)
is: SBO:0000176
reversible: true
fast: false
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/1.1.1.42
reactant: MODEL1310110061#
modifier: MODEL1310110061#

metaR RE0958E
reactant: MODEL1310110061#
reversible: true
is version of: http://identifiers.org/ec-code/3.2.1.1
name: RE0958
is version of: http://identifiers.org/ec-code/3.2.1.17
product: MODEL1310110061#
modifier: MODEL1310110061#
kinetic law: MODEL1310110061#
fast: false
is described by: ECO:0000000
type: Reaction
is: SBO:0000176
notes: GENE_ASSOCIATION: (276.1) or (277.1) or (278.1) or (279.1) or (276.1) or (277.1) or (278.1) or (279.1) or (280.1) or (84569.1) SUBSYSTEM: Starch and sucrose metabolism EC Number: 3.2.1.1 Confidence Level: 0 AUTHORS: PMID:8528071,PMID:890964 NOTES:

metaR XYLUR
product: MODEL1310110061#
is: SBO:0000176
modifier: MODEL1310110061#
fast: false
kinetic law: MODEL1310110061#
reactant: MODEL1310110061#
is version of: http://identifiers.org/ec-code/1.1.1.10
type: Reaction
notes: GENE_ASSOCIATION: (51181.1) SUBSYSTEM: Pentose phosphate pathway EC Number: 1.1.1.10 Confidence Level: 4 AUTHORS: PMID:11882650,PMID:6821187 NOTES:
is described by: ECO:0000269
reversible: true
name: xylulose reductase

http://identifiers.org/biomodels.db/MODEL1310110061#_5f2928f9_3eb5_46dc_9c44_edfcbc510cd5
name: ATP2B3
type: Species
is: Q16720
boundary condition: true
is encoded by: hsa:492
has only substance units: false
constant: false
initial amount: NaN
initial concentration: NaN
is: SBO:0000252

metaR A4GALTg
is: SBO:0000176
modifier: MODEL1310110061#
product: MODEL1310110061#
kinetic law: MODEL1310110061#
type: Reaction
is version of: http://identifiers.org/ec-code/2.4.1.228
reversible: false
is described by: ECO:0000269
name: Lactosylceramide 4-alpha-galactosyltransferase
notes: GENE_ASSOCIATION: (53947.1) SUBSYSTEM: Sphingolipid metabolism EC Number: 2.4.1.228 Confidence Level: 4 AUTHORS: PMID:10747952,PMID:10748143 NOTES:EC: 2.4.1.228 NJ
reactant: MODEL1310110061#
fast: false

http://identifiers.org/biomodels.db/MODEL1310110061#_29b2a550_cdda_4eff_a983_f67217022c73
boundary condition: true
type: Species
initial amount: NaN
has only substance units: false
initial concentration: NaN
is encoded by: hsa:728441
name: GGT2
constant: false
is: SBO:0000252

metaM oxa m
is: SBO:0000247
initial amount: NaN
type: Species
has only substance units: false
boundary condition: false
is: HMDB02329
constant: false
is: CHEBI:30623
initial concentration: 1.0
name: oxalate(2-)
notes: FORMULA: C2O4 CHARGE: -2 INCHI: InChI=1S/C2H2O4/c3-1(4)2(5)6/h(H,3,4)(H,5,6)/p-2 HEPATONET_1.0_ABBREVIATION: HC00195 EHMN_ABBREVIATION: C00209

metaR RIBt2
name: ribose transport in via proton symporter
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:15234337 NOTES:NCD
kinetic law: MODEL1310110061#
reactant: MODEL1310110061#
type: Reaction
reversible: false
is described by: ECO:0000000
fast: false
product: MODEL1310110061#
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110061#_a67e7d3e_4b24_4908_8f8f_d69790d60488
boundary condition: true
type: Species
has only substance units: false
name: MVD
initial concentration: NaN
is: P53602
initial amount: NaN
is: SBO:0000252
is encoded by: hsa:4597
constant: false

metaR DHFR
kinetic law: MODEL1310110061#
type: Reaction
reversible: true
is: SBO:0000176
fast: false
modifier: MODEL1310110061#
notes: GENE_ASSOCIATION: (1719.1) SUBSYSTEM: Folate metabolism EC Number: 1.5.1.3 Confidence Level: 2 AUTHORS: PMID:6504041 NOTES:
name: dihydrofolate reductase
reactant: MODEL1310110061#
product: MODEL1310110061#
is version of: http://identifiers.org/ec-code/1.5.1.3
is described by: ECO:0000254

metaR R group phosphotase 1
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: Confidence Level: AUTHORS: NOTES:
reactant: MODEL1310110061#
is: SBO:0000176
is described by: ECO:0000000
name: R group phosphotase 1
kinetic law: MODEL1310110061#
type: Reaction
reversible: false
product: MODEL1310110061#

metaR EX CE2250 LPAREN e RPAREN
kinetic law: MODEL1310110061#
reactant: MODEL1310110061#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 3-oxodocosanoyl-CoA exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110061#_35924bd7_8703_4b8e_8122_dd639d662a4f
name: NDUFA6
constant: false
is encoded by: hsa:4700
initial amount: NaN
is: P56556
has only substance units: false
boundary condition: true
initial concentration: NaN
type: Species
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110061#_b65d5c7d_fa69_4786_af4b_055025614420
constant: false
is: SBO:0000252
is: Q70HW3
initial amount: NaN
boundary condition: true
name: SLC25A26
has only substance units: false
type: Species
initial concentration: NaN
is encoded by: hsa:115286

metaM mercppyr c
notes: FORMULA: C3H3O3S CHARGE: -1 INCHI: InChI=1S/C3H4O3S/c4-2(1-7)3(5)6/h7H,1H2,(H,5,6)/p-1 HEPATONET_1.0_ABBREVIATION: HC00600 EHMN_ABBREVIATION: C00957
is: CHEBI:57678
boundary condition: false
is: SBO:0000247
type: Species
name: 3-mercaptopyruvate
has only substance units: false
initial amount: NaN
initial concentration: 1.0
constant: false
is: HMDB01368

metaR PROSTGI2t
product: MODEL1310110061#
type: Reaction
is: SBO:0000185
is described by: ECO:0000269
kinetic law: MODEL1310110061#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:12827517,PMID:12883891,PMID:9187257 NOTES:
reactant: MODEL1310110061#
reversible: true
name: Prostaglandin I2 transport
fast: false

http://identifiers.org/biomodels.db/MODEL1310110061#_4e71f285_784d_42c6_8aa4_e99e2458f339
is: SBO:0000252
constant: false
initial amount: NaN
type: Species
name: PTGDS
is encoded by: hsa:5730
has only substance units: false
is: P41222
initial concentration: NaN
boundary condition: true

metaM succ c
is: C00042
is: SBO:0000247
has only substance units: false
is: CHEBI:30031
boundary condition: false
constant: false
type: Species
initial concentration: 1.0
initial amount: NaN
notes: FORMULA: C4H4O4 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00049 EHMN_ABBREVIATION: C00042
is: HMDB00254
name: Succinate

metaR R group phosphotase 2
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: Confidence Level: AUTHORS: NOTES:
type: Reaction
reversible: false
product: MODEL1310110061#
reactant: MODEL1310110061#
is: SBO:0000176
kinetic law: MODEL1310110061#
is described by: ECO:0000000
fast: false
name: R group phosphotase 2

metaR DRPA
is: SBO:0000176
fast: false
reversible: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Pentose phosphate pathway EC Number: 4.1.2.4 Confidence Level: 2 AUTHORS: NOTES:
is described by: ECO:0000000
type: Reaction
name: deoxyribose-phosphate aldolase
product: MODEL1310110061#
kinetic law: MODEL1310110061#
reactant: MODEL1310110061#

metaR r0170
name: Farnesyl-diphosphate:farnesyl-diphosphate farnesyltransferase Biosynthesis of steroids EC:2.5.1.21
is described by: ECO:0000000
modifier: MODEL1310110061#
product: MODEL1310110061#
notes: GENE_ASSOCIATION: (H77542.1) or (5313.1) or (5315.1) SUBSYSTEM: Cholesterol metabolism EC Number: 2.5.1.21 Confidence Level: 0 AUTHORS: PMID:11108725,PMID:1527001,PMID:17180682,PMID:7864626,PMID:8509416 NOTES:
type: Reaction
is version of: http://identifiers.org/ec-code/2.7.1.40
reversible: true
fast: false
kinetic law: MODEL1310110061#
reactant: MODEL1310110061#
is: SBO:0000176

metaR SR5ARr
name: 3-oxo-5-alpha-steroid 4-dehydrogenase
reversible: false
product: MODEL1310110061#
modifier: MODEL1310110061#
is described by: ECO:0000134
reactant: MODEL1310110061#
is: SBO:0000176
kinetic law: MODEL1310110061#
notes: GENE_ASSOCIATION: (6716.1) or (6715.1) SUBSYSTEM: Steroid metabolism EC Number: 1.3.99.5 Confidence Level: 4 AUTHORS: PMID:2339109 NOTES:there are actually two types, but the difference between them lies in optimal pH function - grouped as one reaction at his point to eliminate redundancy. NADP known to be cofactor NJ. human 5alpha-HSD activity determined in transfected COS cells using C-14 labelled testosterone as substrate
type: Reaction
fast: false
is version of: http://identifiers.org/ec-code/1.3.99.5

http://identifiers.org/biomodels.db/MODEL1310110061#_870762c4_6972_4677_9704_cb1008ca9287
has only substance units: false
type: Species
is encoded by: hsa:91734
is: SBO:0000252
initial concentration: NaN
initial amount: NaN
constant: false
is: Q9BXS1
name: IDI2
boundary condition: true

metaM lnlncg e
boundary condition: false
is: SBO:0000247
initial amount: NaN
has only substance units: false
notes: FORMULA: C18H29O2 CHARGE: -1 INCHI: InChI=1S/C18H30O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20/h6-7,9-10,12-13H,2-5,8,11,14-17H2,1H3,(H,19,20)/p-1/b7-6-,10-9-,13-12-
type: Species
constant: false
name: gamma-linolenate
is: CHEBI:32391
initial concentration: 1.0
is: HMDB03073

http://identifiers.org/biomodels.db/MODEL1310110061#_a60facef_38e2_4b47_98ac_14008e695517
is: SBO:0000252
initial amount: NaN
initial concentration: NaN
has only substance units: false
constant: false
is encoded by: hsa:8525
is: G3V0F6
type: Species
name: DGKZ
boundary condition: true

metaM gchola c
type: Species
is: CHEBI:58235
boundary condition: false
name: glycocholate
notes: FORMULA: C26H43NO6 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00863 EHMN_ABBREVIATION: C01921
has only substance units: false
is: HMDB00138
initial amount: NaN
constant: false
is: SBO:0000247
initial concentration: 1.0

metaR PROt4 2 r
reversible: true
modifier: MODEL1310110061#
reactant: MODEL1310110061#
notes: GENE_ASSOCIATION: (6534.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12719981 NOTES:SAB
is: SBO:0000185
type: Reaction
kinetic law: MODEL1310110061#
fast: false
is described by: ECO:0000006
product: MODEL1310110061#
name: Proline transport (sodium symport) (2:1)

http://identifiers.org/biomodels.db/MODEL1310110061#_1adfdde2_2336_43d6_95e2_e5429ac7346b
is: GO:0005777
is: SBO:0000290
constant: false
size: 1.0
spatial dimensions: 3.0
name: peroxisome
type: Compartment

metaM ppi n
is: SBO:0000247
initial amount: NaN
is: CHEBI:33019
has only substance units: false
constant: false
name: diphosphate(3-)
is: HMDB00250
type: Species
initial concentration: 1.0
notes: FORMULA: HO7P2 CHARGE: -3 INCHI: InChI=1S/H4O7P2/c1-8(2,3)7-9(4,5)6/h(H2,1,2,3)(H2,4,5,6)/p-3 HEPATONET_1.0_ABBREVIATION: HC00023 EHMN_ABBREVIATION: C00013
boundary condition: false

metaM txa2 e
type: Species
notes: FORMULA: C20H31O5 CHARGE: -1 INCHI: InChI=1S/C20H32O5/c1-2-3-6-9-15(21)12-13-17-16(18-14-20(24-17)25-18)10-7-4-5-8-11-19(22)23/h4,7,12-13,15-18,20-21H,2-3,5-6,8-11,14H2,1H3,(H,22,23)/p-1/b7-4-,13-12+/t15-,16+,17+,18-,20+/m0/s1 EHMN_ABBREVIATION: C02198
is: CHEBI:57445
initial amount: NaN
initial concentration: 1.0
name: thromboxane A2(1-)
boundary condition: false
constant: false
has only substance units: false
is: HMDB01452
is: SBO:0000247

metaR EX 4pyrdx LPAREN e RPAREN
kinetic law: MODEL1310110061#
reactant: MODEL1310110061#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 4-Pyridoxate exchange
type: Reaction

metaM 4fumacac c
type: Species
has only substance units: false
is: HMDB01268
constant: false
notes: FORMULA: C8H6O6 CHARGE: -2 INCHI: InChI=1S/C8H8O6/c9-5(1-2-7(11)12)3-6(10)4-8(13)14/h1-2H,3-4H2,(H,11,12)(H,13,14)/p-2/b2-1+ HEPATONET_1.0_ABBREVIATION: HC00648 EHMN_ABBREVIATION: C01061
name: 4-fumarylacetoacetate(2-)
initial amount: NaN
is: CHEBI:18034
initial concentration: 1.0
boundary condition: false
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110061#_dbe4cd32_c572_42a3_ba1d_a17e07caa0b8
initial concentration: NaN
type: Species
is: P47989
name: XDH
has only substance units: false
boundary condition: true
initial amount: NaN
is: SBO:0000252
constant: false
is encoded by: hsa:7498

http://identifiers.org/biomodels.db/MODEL1310110061#_4c412d9d_da08_4786_be8d_b6453e56099c
is: SBO:0000252
initial concentration: NaN
initial amount: NaN
has only substance units: false
boundary condition: true
name: BDH1
type: Species
is encoded by: hsa:622
constant: false

metaR EX prostge1 LPAREN e RPAREN
kinetic law: MODEL1310110061#
reactant: MODEL1310110061#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Prostaglandin E1 exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110061#_c3fc31d2_9633_422b_953a_5627398671a5
is: Q86VV3
name: ENTPD1
has only substance units: false
constant: false
initial concentration: NaN
is encoded by: hsa:953
initial amount: NaN
type: Species
is: SBO:0000252
boundary condition: true

metaR r0504
modifier: MODEL1310110061#
product: MODEL1310110061#
fast: false
kinetic law: MODEL1310110061#
is version of: http://identifiers.org/ec-code/2.3.3.10
is: SBO:0000176
reversible: true
name: Xanthine:oxygen oxidoreductase Purine metabolism EC:1.17.3.2
reactant: MODEL1310110061#
notes: GENE_ASSOCIATION: (AI090874.1) or (AL048840.1) or (BG035985.1) or (3157.1) or (3158.1) SUBSYSTEM: Purine catabolism EC Number: 1.17.3.2 Confidence Level: 0 AUTHORS: PMID:16087479,PMID:1643670,PMID:16756494,PMID:18600557,PMID:8343533 NOTES:
type: Reaction
is described by: ECO:0000000

metaR ME2m
reactant: MODEL1310110061#
kinetic law: MODEL1310110061#
is version of: http://identifiers.org/ec-code/1.1.1.40
reversible: false
is: SBO:0000176
fast: false
modifier: MODEL1310110061#
is version of: http://identifiers.org/ec-code/1.1.1.38
product: MODEL1310110061#
is described by: ECO:0000000
type: Reaction
notes: GENE_ASSOCIATION: (4200.1) or (10873.1) SUBSYSTEM: Pyruvate metabolism EC Number: 1.1.1.40 Confidence Level: 0 AUTHORS: PMID:1993674 NOTES:IF
name: malic enzyme (NADP), mitochondrial

metaM ach c
name: acetylcholine
constant: false
boundary condition: false
is: CHEBI:15355
type: Species
is: SBO:0000247
has only substance units: false
is: HMDB00895
initial concentration: 1.0
notes: FORMULA: C7H16NO2 CHARGE: 1 INCHI: InChI=1S/C7H16NO2/c1-7(9)10-6-5-8(2,3)4/h5-6H2,1-4H3/q+1 HEPATONET_1.0_ABBREVIATION: HC00877 EHMN_ABBREVIATION: C01996
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110061#_749446e0_25ed_4c82_94b9_0268950f1dbb
is: SBO:0000252
is encoded by: hsa:2936
name: GSR
is: P00390
constant: false
type: Species
has only substance units: false
initial concentration: NaN
initial amount: NaN
boundary condition: true

metaR EX dhap LPAREN e RPAREN
kinetic law: MODEL1310110061#
reactant: MODEL1310110061#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of glycerone phosphate(2-)
type: Reaction

metaR EX gluala LPAREN e RPAREN
kinetic law: MODEL1310110061#
reactant: MODEL1310110061#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 5-L-Glutamyl-L-alanine exchange
type: Reaction

metaM ptth m
name: pantetheine
is: SBO:0000247
is: HMDB03426
initial amount: NaN
type: Species
notes: FORMULA: C11H22N2O4S CHARGE: 0 INCHI: InChI=1S/C11H22N2O4S/c1-11(2,7-14)9(16)10(17)13-4-3-8(15)12-5-6-18/h9,14,16,18H,3-7H2,1-2H3,(H,12,15)(H,13,17)/t9-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00554 EHMN_ABBREVIATION: C00831
initial concentration: 1.0
constant: false
is: CHEBI:16753
has only substance units: false
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110061#_19f15b02_4896_4a07_8bf7_239e4cc96a52
type: Species
constant: false
is encoded by: hsa:56606
initial amount: NaN
is: SBO:0000252
boundary condition: true
has only substance units: false
is: Q9NRM0
initial concentration: NaN
name: SLC2A9

http://identifiers.org/biomodels.db/MODEL1310110061#_a5610e92_a626_4f70_9400_15c2e6ad45fa
is: B4DUY1
initial amount: NaN
type: Species
has only substance units: false
boundary condition: true
constant: false
is encoded by: hsa:10948
initial concentration: NaN
is: SBO:0000252
name: STARD3

metaM andrstandn r
is: CHEBI:15994
constant: false
is: SBO:0000247
is: HMDB00899
type: Species
boundary condition: false
initial amount: NaN
name: 5alpha-androstane-3,17-dione
has only substance units: false
notes: FORMULA: C19H28O2 CHARGE: 0 INCHI: InChI=1S/C19H28O2/c1-18-9-7-13(20)11-12(18)3-4-14-15-5-6-17(21)19(15,2)10-8-16(14)18/h12,14-16H,3-11H2,1-2H3/t12-,14-,15-,16-,18-,19-/m0/s1 EHMN_ABBREVIATION: C00674
initial concentration: 1.0

metaM gchola e
is: HMDB00138
has only substance units: false
name: glycocholate
constant: false
initial amount: NaN
boundary condition: false
notes: FORMULA: C26H43NO6 CHARGE: 0
is: SBO:0000247
initial concentration: 1.0
type: Species

metaM ppi m
name: Diphosphate
initial concentration: 1.0
is: C00013
boundary condition: false
is: SBO:0000247
notes: FORMULA: HO7P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00023 EHMN_ABBREVIATION: C00013
initial amount: NaN
is: CHEBI:33019
has only substance units: false
constant: false
is: HMDB00250
type: Species

http://identifiers.org/biomodels.db/MODEL1310110061#_80e596fd_4654_4078_80b3_28c76f37c1b1
is encoded by: hsa:221
boundary condition: true
constant: false
is: P43353
initial amount: NaN
type: Species
initial concentration: NaN
is: SBO:0000252
name: ALDH3B1
has only substance units: false

metaR DPCOAK
notes: GENE_ASSOCIATION: (80347.1) SUBSYSTEM: CoA synthesis EC Number: Confidence Level: 4 AUTHORS: NOTES:
reversible: false
reactant: MODEL1310110061#
is: SBO:0000176
type: Reaction
name: dephospho-CoA kinase
fast: false
kinetic law: MODEL1310110061#
product: MODEL1310110061#
is version of: http://identifiers.org/ec-code/2.7.7.3
is described by: ECO:0000269
modifier: MODEL1310110061#

metaR r0394
notes: GENE_ASSOCIATION: SUBSYSTEM: Nucleotide interconversion EC Number: 1.17.1.4 Confidence Level: 0 AUTHORS: PMID:2713424,PMID:8248161 NOTES:
kinetic law: MODEL1310110061#
fast: false
reversible: true
name: Xanthine:NAD+ oxidoreductase Purine metabolism EC:1.17.1.4
product: MODEL1310110061#
is: SBO:0000176
is described by: ECO:0000000
reactant: MODEL1310110061#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110061#_873e48d8_8b07_40b7_87a4_43672940b20a
type: Species
is: SBO:0000252
initial concentration: NaN
is encoded by: hsa:5298
constant: false
initial amount: NaN
name: PI4KB
has only substance units: false
is: Q9UBF8
boundary condition: true

metaM coucoa m
type: Species
is: C00223
constant: false
is: SBO:0000247
is: CHEBI:57355
boundary condition: false
notes: FORMULA: C30H38N7O18P3S1 CHARGE: -4 INCHI: InChI=1S/C30H42N7O18P3S/c1-30(2,25(42)28(43)33-10-9-20(39)32-11-12-59-21(40)8-5-17-3-6-18(38)7-4-17)14-52-58(49,50)55-57(47,48)51-13-19-24(54-56(44,45)46)23(41)29(53-19)37-16-36-22-26(31)34-15-35-27(22)37/h3-8,15-16,19,23-25,29,38,41-42H,9-14H2,1-2H3,(H,32,39)(H,33,43)(H,47,48)(H,49,50)(H2,31,34,35)(H2,44,45,46)/p-4/t19-,23-,24-,25+,29-/m1/s1
has only substance units: false
name: 4-coumaroyl-CoA(4-)
initial concentration: 1.0
initial amount: NaN

metaR r0311
type: Reaction
reversible: false
is: SBO:0000176
name: Palmitate:CoA ligase (AMP-forming) Fatty acid metabolism EC:6.2.1.3
modifier: MODEL1310110061#
notes: GENE_ASSOCIATION: (30.1) or (10449.1) or (38.1) or (39.1) or (3032.1) or (4645.1) SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 0 AUTHORS: PMID:8584017 NOTES:
is version of: http://identifiers.org/ec-code/2.3.1.16
product: MODEL1310110061#
reactant: MODEL1310110061#
kinetic law: MODEL1310110061#
is described by: ECO:0000000
fast: false
is version of: http://identifiers.org/ec-code/2.3.1.9

http://identifiers.org/biomodels.db/MODEL1310110061#_52d92d2f_0d71_452c_83b4_7d4decfaee15
is: Q8TDQ7
name: GNPDA2
constant: false
has only substance units: false
type: Species
is encoded by: hsa:132789
is: SBO:0000252
initial concentration: NaN
initial amount: NaN
boundary condition: true

metaM dopa e
boundary condition: false
is: CHEBI:59905
is: HMDB00073
constant: false
initial amount: NaN
notes: FORMULA: C8H12NO2 CHARGE: 1 INCHI: InChI=1S/C8H11NO2/c9-4-3-6-1-2-7(10)8(11)5-6/h1-2,5,10-11H,3-4,9H2/p+1 HEPATONET_1.0_ABBREVIATION: HC01175 EHMN_ABBREVIATION: C03758
has only substance units: false
initial concentration: 1.0
type: Species
is: SBO:0000247
name: dopaminium(1+)

http://identifiers.org/biomodels.db/MODEL1310110061#_a532051e_ca99_4b23_8297_b93fc7a38591
constant: false
is: Q9NVS9
boundary condition: true
is encoded by: hsa:55163
has only substance units: false
is: SBO:0000252
type: Species
initial amount: NaN
name: PNPO
initial concentration: NaN

metaM CE2417 m
has only substance units: false
is: HMDB11123
constant: false
name: 3(S)-hydroxy-5Z,8Z-tetradecadienoyl-CoA
is: SBO:0000247
initial concentration: 1.0
type: Species
is: CHEBI:28387
boundary condition: false
initial amount: NaN
notes: FORMULA: C35H54N7O18P3S CHARGE: -4 INCHI: InChI=1/C35H58N7O18P3S/c1-4-5-6-7-8-9-10-11-12-13-23(43)18-26(45)64-17-16-37-25(44)14-15-38-33(48)30(47)35(2,3)20-57-63(54,55)60-62(52,53)56-19-24-29(59-61(49,50)51)28(46)34(58-24)42-22-41-27-31(36)39-21-40-32(27)42/h8-9,11-12,21-24,28-30,34,43,46-47H,4-7,10,13-20H2,1-3H3,(H,37,44)(H,38,48)(H,52,53)(H,54,55)(H2,36,39,40)(H2,49,50,51)/p-4/b9-8-,12-11-/t23-,24-,28+,29+,30u,34-/m0/s1 EHMN_ABBREVIATION: CE2417

metaR r0281
type: Reaction
notes: GENE_ASSOCIATION: (22934.1) SUBSYSTEM: Methionine and cysteine metabolism EC Number: 1.4.3.6 Confidence Level: 0 AUTHORS: PMID:12072962,PMID:15795708,PMID:17006978,PMID:6403048 NOTES:
reactant: MODEL1310110061#
product: MODEL1310110061#
reversible: true
name: Putrescine:oxygen oxidoreductase (deaminating) Urea cycle and metabolism of amino groups EC:1.4.3.6
is version of: http://identifiers.org/ec-code/5.3.1.6
kinetic law: MODEL1310110061#
is: SBO:0000176
modifier: MODEL1310110061#
is described by: ECO:0000000
fast: false

metaR DECDPtm
name: lipid, flip-flop intracellular transport
kinetic law: MODEL1310110061#
reactant: MODEL1310110061#
fast: false
type: Reaction
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: PMID:12840657 NOTES:ubiquinone precursor, transport by "diffusion" -> actually beleived to be flip-flop mechanism (PMID: 12840657). NJ
is: SBO:0000185
is described by: ECO:0000000
product: MODEL1310110061#

metaM 10fthf5glu e
notes: FORMULA: C40H45N11O19 CHARGE: -6
constant: false
is: SBO:0000247
initial amount: NaN
is: CHEBI:57454
type: Species
boundary condition: false
has only substance units: false
name: 10-formyltetrahydrofolate-[Glu](5)
is: HMDB00972
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110061#_eeba52b5_5620_4def_b001_67e25f2e72d4
name: ECHS1
initial amount: NaN
initial concentration: NaN
type: Species
is encoded by: hsa:1892
boundary condition: true
is: P30084
is: SBO:0000252
constant: false
has only substance units: false

metaM CE0713 m
has only substance units: false
initial amount: NaN
constant: false
notes: FORMULA: C39H60N7O18P3S CHARGE: -4 INCHI: InChI=1/C39H64N7O18P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-27(47)22-30(49)68-21-20-41-29(48)18-19-42-37(52)34(51)39(2,3)24-61-67(58,59)64-66(56,57)60-23-28-33(63-65(53,54)55)32(50)38(62-28)46-26-45-31-35(40)43-25-44-36(31)46/h8-9,11-12,25-26,28,32-34,38,50-51H,4-7,10,13-24H2,1-3H3,(H,41,48)(H,42,52)(H,56,57)(H,58,59)(H2,40,43,44)(H2,53,54,55)/p-4/b9-8-,12-11-/t28-,32+,33+,34u,38-/m0/s1 EHMN_ABBREVIATION: CE0713
boundary condition: false
name: 3-oxolinoleoyl-CoA
is: HMDB02329
initial concentration: 1.0
is: SBO:0000247
is: CHEBI:30623
type: Species

http://identifiers.org/biomodels.db/MODEL1310110061#_e4b60ef1_f222_488b_86ea_721c20c9f62f
is encoded by: hsa:51109
has only substance units: false
boundary condition: true
initial concentration: NaN
type: Species
is: B4DDW0
name: RDH11
initial amount: NaN
constant: false
is: SBO:0000252

metaM tyr L e
initial amount: NaN
is: SBO:0000247
type: Species
name: L-tyrosine
notes: FORMULA: C9H11NO3 CHARGE: 0 INCHI: InChI=1S/C9H11NO3/c10-8(9(12)13)5-6-1-3-7(11)4-2-6/h1-4,8,11H,5,10H2,(H,12,13)/t8-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00085
has only substance units: false
is: HMDB00158
constant: false
initial concentration: 1.0
is: CHEBI:17895
boundary condition: false

metaR r0594
reactant: MODEL1310110061#
notes: GENE_ASSOCIATION: (AA081045.1) or (AI620219.1) or (219.1) or (217.1) or (224.1) or (501.1) or (223.1) or (AU149534.1) or (T83654.1) SUBSYSTEM: Lysine metabolism EC Number: 1.2.1.31 Confidence Level: 0 AUTHORS: PMID:2160277 NOTES:
is: SBO:0000176
modifier: MODEL1310110061#
fast: false
reversible: true
is version of: http://identifiers.org/ec-code/1.2.1.3
product: MODEL1310110061#
is described by: ECO:0000000
type: Reaction
kinetic law: MODEL1310110061#
name: L-2-Aminoadipate-6-semialdehyde:NAD+ 6-oxidoreductase Lysine degradation EC:1.2.1.31

metaR MANtly
is: SBO:0000185
reactant: MODEL1310110061#
is described by: ECO:0000000
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 2 AUTHORS: PMID:1751541,PMID:8993166 NOTES:NCD
type: Reaction
kinetic law: MODEL1310110061#
product: MODEL1310110061#
name: mannose efflux from lysosome
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110061#_86304a27_b9da_407c_add1_daeafc45aa21
has only substance units: false
constant: false
type: Species
boundary condition: true
is encoded by: hsa:3283
is: P14060
name: HSD3B1
initial amount: NaN
is: SBO:0000252
initial concentration: NaN

metaM lnlncg c
notes: FORMULA: C18H29O2 CHARGE: -1 INCHI: InChI=1S/C18H30O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20/h6-7,9-10,12-13H,2-5,8,11,14-17H2,1H3,(H,19,20)/p-1/b7-6-,10-9-,13-12-
is: CHEBI:32391
type: Species
initial amount: NaN
is: HMDB03073
constant: false
initial concentration: 1.0
boundary condition: false
name: gamma-linolenate
is: SBO:0000247
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110061#_e17c4a96_3365_4589_81b9_09bb3c937712
has only substance units: false
name: ENTPD4
constant: false
initial concentration: NaN
boundary condition: true
is encoded by: hsa:9583
is: SBO:0000252
type: Species
initial amount: NaN
is: Q9Y227

metaM txa2 c
is: HMDB01452
is: SBO:0000247
notes: FORMULA: C20H31O5 CHARGE: -1 INCHI: InChI=1S/C20H32O5/c1-2-3-6-9-15(21)12-13-17-16(18-14-20(24-17)25-18)10-7-4-5-8-11-19(22)23/h4,7,12-13,15-18,20-21H,2-3,5-6,8-11,14H2,1H3,(H,22,23)/p-1/b7-4-,13-12+/t15-,16+,17+,18-,20+/m0/s1 EHMN_ABBREVIATION: C02198
type: Species
name: thromboxane A2(1-)
initial concentration: 1.0
is: CHEBI:57445
boundary condition: false
initial amount: NaN
has only substance units: false
constant: false

http://identifiers.org/biomodels.db/MODEL1310110061#_cd9ffe32_de79_42fc_945d_2c4636a1197e
is: SBO:0000252
is encoded by: hsa:83715
has only substance units: false
constant: false
initial amount: NaN
is: B1AK53
type: Species
boundary condition: true
initial concentration: NaN
name: ESPN

metaR MI4PP
notes: GENE_ASSOCIATION: (3612.1) or (3613.1) SUBSYSTEM: Inositol phosphate metabolism EC Number: 3.1.3.25 Confidence Level: 4 AUTHORS: PMID:1377913,PMID:2906139,PMID:9322233 NOTES:NCD
is described by: ECO:0000269
name: myo-inositol 4-phosphatase
is: SBO:0000176
type: Reaction
reactant: MODEL1310110061#
modifier: MODEL1310110061#
fast: false
product: MODEL1310110061#
kinetic law: MODEL1310110061#
reversible: false
is version of: http://identifiers.org/ec-code/3.1.3.25

metaM nac c
is: C00253
is: SBO:0000247
initial concentration: 1.0
initial amount: NaN
constant: false
type: Species
notes: FORMULA: C6H4NO2 CHARGE: -1
boundary condition: false
is: CHEBI:0
has only substance units: false
name: Nicotinate
is: HMDB01488

metaR RE3627M
is version of: http://identifiers.org/ec-code/4.2.1.107
reactant: MODEL1310110061#
kinetic law: MODEL1310110061#
type: Reaction
product: MODEL1310110061#
reversible: true
fast: false
name: RE3627
is version of: http://identifiers.org/ec-code/1.1.1.35
notes: GENE_ASSOCIATION: (3295.1) or (1962.1) or (3033.1) or (3028.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.1.1.35 Confidence Level: 0 AUTHORS: PMID:11356164,PMID:7775433 NOTES:
modifier: MODEL1310110061#
is: SBO:0000176
is described by: ECO:0000000

metaM pristcoa x
boundary condition: false
constant: false
name: pristanoyl coa
type: Species
is: SBO:0000247
initial concentration: 1.0
is: CHEBI:51341
initial amount: NaN
has only substance units: false
notes: FORMULA: C40H68N7O17P3S CHARGE: -4 INCHI: InChI=1/C40H72N7O17P3S/c1-25(2)11-8-12-26(3)13-9-14-27(4)15-10-16-28(5)39(52)68-20-19-42-30(48)17-18-43-37(51)34(50)40(6,7)22-61-67(58,59)64-66(56,57)60-21-29-33(63-65(53,54)55)32(49)38(62-29)47-24-46-31-35(41)44-23-45-36(31)47/h23-29,32-34,38,49-50H,8-22H2,1-7H3,(H,42,48)(H,43,51)(H,56,57)(H,58,59)(H2,41,44,45)(H2,53,54,55)/t26?,27?,28?,29-,32-,33-,34+,38-/m1/s1/f/h42-43,53-54,56,58H,41H2

metaM pectintchol e
notes: FORMULA: C2561H3555NO2542S CHARGE: 0
constant: false
initial concentration: 1.0
boundary condition: false
is: SBO:0000247
name: pectin-taurocholic acid complex
is: HMDB03402
initial amount: NaN
has only substance units: false
type: Species

metaR DESAT24 1
kinetic law: MODEL1310110061#
notes: GENE_ASSOCIATION: (9415.1) SUBSYSTEM: Fatty acid synthesis EC Number: 1.14.99.25 Confidence Level: 4 AUTHORS: NOTES:for homo sapiens, noted to actually be NADH-cyt b5, using NADH at present NJ
fast: false
product: MODEL1310110061#
reactant: MODEL1310110061#
is described by: ECO:0000269
is: SBO:0000176
name: fatty acyl-CoA desaturase (n-C24:5CoA -> n-C24:6CoA)
modifier: MODEL1310110061#
reversible: false
type: Reaction

metaR LPCHOLt
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:9430701 NOTES:
reversible: true
reactant: MODEL1310110061#
is described by: ECO:0000000
is: SBO:0000185
type: Reaction
product: MODEL1310110061#
kinetic law: MODEL1310110061#
fast: false
name: lysophosphatidylcholine transport

http://identifiers.org/biomodels.db/MODEL1310110061#_77014ca4_7841_471b_a5b5_fce229d4169b
is encoded by: hsa:23057
is: SBO:0000252
boundary condition: true
has only substance units: false
initial amount: NaN
name: NMNAT2
constant: false
initial concentration: NaN
type: Species

metaM btamp m
initial concentration: 1.0
is: CHEBI:3110
type: Species
boundary condition: false
constant: false
notes: FORMULA: C20H27N7O9PS CHARGE: -1 INCHI: InChI=1S/C20H28N7O9PS/c21-17-14-18(23-7-22-17)27(8-24-14)19-16(30)15(29)10(35-19)5-34-37(32,33)36-12(28)4-2-1-3-11-13-9(6-38-11)25-20(31)26-13/h7-11,13,15-16,19,29-30H,1-6H2,(H,32,33)(H2,21,22,23)(H2,25,26,31)/t9-,10+,11-,13-,15+,16+,19+/m0/s1 EHMN_ABBREVIATION: C05921
initial amount: NaN
has only substance units: false
name: Biotinyl-5'-AMP
is: HMDB04220
is: SBO:0000247

metaR EX q10h2 LPAREN e RPAREN
kinetic law: MODEL1310110061#
reactant: MODEL1310110061#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for ubiquinol
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110061#_3055924b_3d78_44c6_bac3_0b772e9e3f5e
is: Q53HE2
name: TPI1
has only substance units: false
boundary condition: true
is: SBO:0000252
type: Species
initial amount: NaN
is encoded by: hsa:7167
initial concentration: NaN
constant: false

metaR EX aicar LPAREN e RPAREN
kinetic law: MODEL1310110061#
reactant: MODEL1310110061#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: Exchange of 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide(2-)
type: Reaction

metaR HMGCOAtx
is described by: ECO:0000000
type: Reaction
fast: false
product: MODEL1310110061#
reversible: true
reactant: MODEL1310110061#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: PMID:14713247 NOTES:diffusion NJ
kinetic law: MODEL1310110061#
is: SBO:0000185
name: Hydroxymethylglutaryl-CoA reversible peroxisomal transport

http://identifiers.org/biomodels.db/MODEL1310110061#_935d2863_5202_4b47_9df5_a1d3dac8f201
is: SBO:0000252
constant: false
is: P43353
initial concentration: NaN
is encoded by: hsa:221
type: Species
has only substance units: false
initial amount: NaN
name: ALDH3B1
boundary condition: true

metaR EX nh4 LPAREN e RPAREN
kinetic law: MODEL1310110061#
reactant: MODEL1310110061#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Ammonia exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110061#_2fed487b_c356_454a_9966_40a138670375
is: P31040
type: Species
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:6389
boundary condition: true
initial concentration: NaN
has only substance units: false
name: SDHA
constant: false

http://identifiers.org/biomodels.db/MODEL1310110061#_ee7e61ea_59b2_4b12_9a43_1206907431b9
initial amount: NaN
type: Species
is: SBO:0000252
has only substance units: false
constant: false
is encoded by: hsa:26289
name: AK5
initial concentration: NaN
boundary condition: true

metaM xol7ah2 c
initial concentration: 1.0
has only substance units: false
name: 5beta-cholestane-3alpha,7alpha-diol
is: HMDB06893
constant: false
initial amount: NaN
boundary condition: false
type: Species
is: SBO:0000247
is: CHEBI:28047
notes: FORMULA: C27H48O2 CHARGE: 0 INCHI: InChI=1S/C27H48O2/c1-17(2)7-6-8-18(3)21-9-10-22-25-23(12-14-27(21,22)5)26(4)13-11-20(28)15-19(26)16-24(25)29/h17-25,28-29H,6-16H2,1-5H3/t18-,19+,20-,21-,22+,23+,24-,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01461 EHMN_ABBREVIATION: C05452

metaM 3hpcoa m
has only substance units: false
boundary condition: false
is: HMDB06807
initial amount: NaN
type: Species
notes: FORMULA: C24H36N7O18P3S CHARGE: -4 INCHI: InChI=1S/C24H40N7O18P3S/c1-24(2,19(36)22(37)27-5-3-14(33)26-6-8-53-15(34)4-7-32)10-46-52(43,44)49-51(41,42)45-9-13-18(48-50(38,39)40)17(35)23(47-13)31-12-30-16-20(25)28-11-29-21(16)31/h11-13,17-19,23,32,35-36H,3-10H2,1-2H3,(H,26,33)(H,27,37)(H,41,42)(H,43,44)(H2,25,28,29)(H2,38,39,40)/p-4/t13-,17-,18-,19+,23-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01557 EHMN_ABBREVIATION: C05668
is: CHEBI:58528
constant: false
initial concentration: 1.0
name: 3-hydroxypropanoyl-CoA(4-)
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110061#_e0d86d31_ea8d_4afa_afe8_7902fd5c6419
initial amount: NaN
name: SLC4A8
is: SBO:0000252
has only substance units: false
is encoded by: hsa:9498
boundary condition: true
initial concentration: NaN
type: Species
constant: false
is: E7EML0

http://identifiers.org/biomodels.db/MODEL1310110061#_9751b0ad_bb2a_410e_9a02_4fdd35018c70
is: SBO:0000252
type: Species
initial amount: NaN
boundary condition: true
is encoded by: hsa:H77542
has only substance units: false
constant: false
initial concentration: NaN
name: _H77542_1_r

metaM HC00664 c
is: SBO:0000247
has only substance units: false
name: D-tagatofuranose 6-phosphate(2-)
type: Species
boundary condition: false
initial amount: NaN
constant: false
notes: FORMULA: C6H11O9P CHARGE: -2 INCHI: InChI=1S/C6H13O9P/c7-2-6(10)5(9)4(8)3(15-6)1-14-16(11,12)13/h3-5,7-10H,1-2H2,(H2,11,12,13)/p-2/t3-,4+,5+,6?/m1/s1 EHMN_ABBREVIATION: C01097
initial concentration: 1.0
is: CHEBI:58695

http://identifiers.org/biomodels.db/MODEL1310110061#_cb97b922_a0c4_43a6_91e3_a95c7cb27aed
initial amount: NaN
is encoded by: hsa:8803
is: SBO:0000297
has part: E5KS60
has only substance units: false
name: SUCLG1:SUCLA2
type: Species
constant: false
initial concentration: NaN
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110061#_e529efc3_a6d1_475a_9e7d_f3d7190bd2b8
name: _U37519_1_e
type: Species
has only substance units: false
initial concentration: NaN
is: SBO:0000252
initial amount: NaN
constant: false
is encoded by: hsa:U37519
boundary condition: true

metaM tyr L c
is: CHEBI:17895
is: SBO:0000247
initial amount: NaN
name: L-tyrosine
has only substance units: false
initial concentration: 1.0
type: Species
notes: FORMULA: C9H11NO3 CHARGE: 0 INCHI: InChI=1S/C9H11NO3/c10-8(9(12)13)5-6-1-3-7(11)4-2-6/h1-4,8,11H,5,10H2,(H,12,13)/t8-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00085
boundary condition: false
is: HMDB00158
constant: false

metaR GULN3D
is: SBO:0000176
type: Reaction
reversible: true
name: L-gulonate 3-dehydrogenase
product: MODEL1310110061#
notes: GENE_ASSOCIATION: SUBSYSTEM: Pentose phosphate pathway EC Number: 1.1.1.45 Confidence Level: 2 AUTHORS: PMID:6821187 NOTES:NCD
kinetic law: MODEL1310110061#
reactant: MODEL1310110061#
fast: false
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110061#_c56a0c5b_74a6_4c87_97fa_0b4a7eab4a78
type: Species
name: HLCS
is: SBO:0000252
boundary condition: true
is encoded by: hsa:3141
is: P50747
has only substance units: false
initial amount: NaN
constant: false
initial concentration: NaN

metaM leuktrA4 r
is: HMDB01337
type: Species
is: CHEBI:57463
has only substance units: false
boundary condition: false
is: SBO:0000247
constant: false
notes: FORMULA: C20H29O3 CHARGE: -1 INCHI: InChI=1S/C20H30O3/c1-2-3-4-5-6-7-8-9-10-11-12-13-15-18-19(23-18)16-14-17-20(21)22/h6-7,9-13,15,18-19H,2-5,8,14,16-17H2,1H3,(H,21,22)/p-1/b7-6-,10-9-,12-11+,15-13+/t18-,19-/m0/s1 EHMN_ABBREVIATION: C00909
initial amount: NaN
initial concentration: 1.0
name: leukotriene A4(1-)

metaR FUCFUCGALACGLCGALGLUSIDEte
reactant: MODEL1310110061#
is: SBO:0000185
kinetic law: MODEL1310110061#
name: blood group intracellular transport
product: MODEL1310110061#
type: Reaction
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:unknown mechanism, however these blood groups need to make it to the extracellular surface of cells NJ
fast: false
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110061#_5a1be4e1_ae23_4231_b344_947229fce04d
is: SBO:0000252
has only substance units: false
name: SLC7A2
boundary condition: true
is encoded by: hsa:6542
initial amount: NaN
is: P52569
initial concentration: NaN
constant: false
type: Species

metaM cgly c
name: L-cysteinylglycine
has only substance units: false
is: CHEBI:4047
boundary condition: false
initial amount: NaN
type: Species
is: SBO:0000247
constant: false
initial concentration: 1.0
notes: FORMULA: C5H10N2O3S CHARGE: 0 INCHI: InChI=1S/C5H10N2O3S/c6-3(2-11)5(10)7-1-4(8)9/h3,11H,1-2,6H2,(H,7,10)(H,8,9)/t3-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00784 EHMN_ABBREVIATION: C01419
is: HMDB00078

metaR r0596
reactant: MODEL1310110061#
name: 3-hydroxyisobutyryl-CoA hydrolase beta-Alanine metabolism / Propanoate metabolism EC:3.1.2.4
reversible: false
is: SBO:0000176
product: MODEL1310110061#
notes: GENE_ASSOCIATION: (6576.1) SUBSYSTEM: CoA synthesis EC Number: 3.1.2.4 Confidence Level: 0 AUTHORS: PMID:10989434,PMID:8188708,PMID:8824301 NOTES:
is described by: ECO:0000000
type: Reaction
fast: false
kinetic law: MODEL1310110061#
modifier: MODEL1310110061#

metaR GGH 10FTHF5GLUe
reactant: MODEL1310110061#
fast: false
modifier: MODEL1310110061#
reversible: false
is: SBO:0000176
kinetic law: MODEL1310110061#
notes: GENE_ASSOCIATION: (8836.1) SUBSYSTEM: Folate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:11375437,PMID:2867095,PMID:9614206 NOTES:REMOVES EITHER ONE OR TWO GLUTAMYL RESIDUES WITH A REACTION (WILL ONLY REPRESENT 1) - last step from 5-glutamyl to monoglutamyl is in one step IT
product: MODEL1310110061#
type: Reaction
is described by: ECO:0000000
name: Gamma-glutamyl hydrolase (10FTHF5GLU), extracellular
is version of: http://identifiers.org/ec-code/3.4.19.9

metaM so3 c
notes: FORMULA: O3S CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00096 EHMN_ABBREVIATION: C00094
initial amount: NaN
is: HMDB00240
initial concentration: 1.0
boundary condition: false
is: CHEBI:17137
is: C00094
constant: false
has only substance units: false
name: Sulfite
is: SBO:0000247
type: Species

metaM 6dhf e
initial amount: NaN
constant: false
notes: FORMULA: C44H49N12O21 CHARGE: -7 INCHI: InChI=1/C44H54N12O21/c45-21(36(66)67)5-10-26(57)43(15-30(61)62,27(58)11-6-22(46)37(68)69)44(28(59)12-7-23(47)38(70)71,41(76)77-31(63)14-9-25(49)40(74)75)56(29(60)13-8-24(48)39(72)73)35(65)18-1-3-19(4-2-18)51-16-20-17-52-33-32(53-20)34(64)55-42(50)54-33/h1-4,17,21-25,51H,5-16,45-49H2,(H,61,62)(H,66,67)(H,68,69)(H,70,71)(H,72,73)(H,74,75)(H3,50,52,54,55,64)/t21-,22-,23-,24-,25-,44+/m0/s1
initial concentration: 1.0
is: HMDB06563
is: SBO:0000247
boundary condition: false
name: hexaglutamyl folate (DHF)
has only substance units: false
type: Species

metaR RE1448N
type: Reaction
is: SBO:0000176
fast: false
is described by: ECO:0000000
reactant: MODEL1310110061#
notes: GENE_ASSOCIATION: SUBSYSTEM: Phosphatidylinositol phosphate metabolism EC Number: 3.1.3.67 Confidence Level: 0 AUTHORS: PMID:7556092,PMID:9367831 NOTES:
reversible: true
name: RE1448
product: MODEL1310110061#
kinetic law: MODEL1310110061#

metaR r0728
is described by: ECO:0000000
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.17 Confidence Level: 0 AUTHORS: PMID:8012501,PMID:8188243 NOTES:
fast: false
reactant: MODEL1310110061#
name: (S)-Hydroxydecanoyl-CoA hydro-lyase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:4.2.1.17
product: MODEL1310110061#
kinetic law: MODEL1310110061#
reversible: true
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110061#_5b113ed0_61c7_4215_9f66_319fc1679142
name: HADH
initial concentration: NaN
constant: false
boundary condition: true
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:3033
type: Species
has only substance units: false
is: Q16836

http://identifiers.org/biomodels.db/MODEL1310110061#_42f8e4cd_3313_46a5_a34d_e3d8b4a13fcf
initial concentration: NaN
is: SBO:0000252
name: _R39999_1_c
has only substance units: false
is encoded by: hsa:R39999
type: Species
initial amount: NaN
constant: false
boundary condition: true

metaR DPHMBDCm
is: SBO:0000176
reversible: false
type: Reaction
fast: false
is described by: ECO:0000000
reactant: MODEL1310110061#
name: 3-Decaprenyl-4-hydroxy-5-methoxybenzoate decarboxylation
product: MODEL1310110061#
kinetic law: MODEL1310110061#
notes: GENE_ASSOCIATION: SUBSYSTEM: Ubiquinone synthesis EC Number: Confidence Level: 2 AUTHORS: PMID:11051212,PMID:7380842 NOTES:enzyme has not been identified yet IT

metaR RETI2
type: Reaction
kinetic law: MODEL1310110061#
is: SBO:0000176
reversible: true
name: retinol isomerase (9-cis)
reactant: MODEL1310110061#
notes: GENE_ASSOCIATION: SUBSYSTEM: Vitamin A metabolism EC Number: 5.2.1.7 Confidence Level: 2 AUTHORS: PMID:1503811 NOTES:IT
fast: false
product: MODEL1310110061#
is described by: ECO:0000000

metaR KSII CORE2tly
is described by: ECO:0000000
kinetic law: MODEL1310110061#
fast: false
reversible: false
product: MODEL1310110061#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 2 AUTHORS: NOTES:
reactant: MODEL1310110061#
is: SBO:0000185
name: keratan sulfate II (core 2) transport, extracellular to lysosome

metaR r0391
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: NAD metabolism EC Number: 2.4.2.11 Confidence Level: 0 AUTHORS: PMID:17604275 NOTES:
type: Reaction
fast: false
name: Nicotinate D-ribonucleotide:pyrophosphate phosphoribosyltransferase Nicotinate and nicotinamide metabolism EC:2.4.2.11
reactant: MODEL1310110061#
is: SBO:0000176
is described by: ECO:0000000
product: MODEL1310110061#
kinetic law: MODEL1310110061#

http://identifiers.org/biomodels.db/MODEL1310110061#_0c53c3e2_ffdc_41a1_a469_b7b6a96f1efe
type: Species
initial amount: NaN
boundary condition: true
has only substance units: false
initial concentration: NaN
constant: false
is encoded by: hsa:2987
is: Q16774
name: GUK1
is: SBO:0000252

metaR r0287
notes: GENE_ASSOCIATION: (6576.1) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.16 Confidence Level: 0 AUTHORS: PMID:10806397,PMID:1121274,PMID:1679347,PMID:1735445,PMID:1979337,PMID:2048733,PMID:3194209,PMID:6378901,PMID:8241273 NOTES:
product: MODEL1310110061#
reactant: MODEL1310110061#
fast: false
reversible: false
is: SBO:0000176
type: Reaction
is described by: ECO:0000000
name: Acetyl-CoA:acetyl-CoA C-acetyltransferase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:2.3.1.16
modifier: MODEL1310110061#
kinetic law: MODEL1310110061#

http://identifiers.org/biomodels.db/MODEL1310110061#_93438600_a692_4879_8fe0_2fe1568bd317
initial amount: NaN
name: UCK2
is: SBO:0000252
constant: false
is encoded by: hsa:7371
is: Q9BZX2
boundary condition: true
initial concentration: NaN
type: Species
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110061#_0acf615f_b9b1_433c_a36c_5a748b7a5822
has only substance units: false
is encoded by: hsa:29880
is: SBO:0000252
constant: false
is: Q9Y673
boundary condition: true
type: Species
initial concentration: NaN
initial amount: NaN
name: ALG5

metaM sph1p e
boundary condition: false
constant: false
has only substance units: false
type: Species
is: SBO:0000247
initial concentration: 1.0
initial amount: NaN
name: (2S,3R)-2-azaniumyl-3-hydroxyoctadecyl phosphate
is: CHEBI:57939
notes: FORMULA: C18H39NO5P CHARGE: -1 INCHI: InChI=1S/C18H40NO5P/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-18(20)17(19)16-24-25(21,22)23/h17-18,20H,2-16,19H2,1H3,(H2,21,22,23)/p-1/t17-,18+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00675 EHMN_ABBREVIATION: C01120
is: HMDB01383

metaR RDH3
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (5959.1) SUBSYSTEM: Vitamin A metabolism EC Number: 1.1.1.105 Confidence Level: 4 AUTHORS: PMID:12226107,PMID:1503811,PMID:7836368 NOTES:IT
fast: false
reactant: MODEL1310110061#
kinetic law: MODEL1310110061#
is version of: http://identifiers.org/ec-code/1.1.1.315
modifier: MODEL1310110061#
reversible: true
is: SBO:0000176
type: Reaction
name: retinol dehydrogenase (11-cis,NADH)
product: MODEL1310110061#

metaM lneldc e
notes: FORMULA: C18H31O2 CHARGE: -1 INCHI: InChI=1/C18H32O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20/h6-7,9-10H,2-5,8,11-17H2,1H3,(H,19,20)/b7-6+,10-9+
has only substance units: false
initial concentration: 1.0
is: HMDB06270
initial amount: NaN
name: linoelaidic acid (all trans C18:2)
boundary condition: false
type: Species
is: SBO:0000247
constant: false

metaR ADSS
name: adenylosuccinate synthase
notes: GENE_ASSOCIATION: (159.1) or (122622.1) or (122622.2) SUBSYSTEM: Nucleotide interconversion EC Number: 6.3.4.4 Confidence Level: 2 AUTHORS: PMID:1592113 NOTES:r0277
is: SBO:0000176
is version of: http://identifiers.org/ec-code/6.3.4.4
modifier: MODEL1310110061#
reversible: false
fast: false
is described by: ECO:0000134
type: Reaction
reactant: MODEL1310110061#
product: MODEL1310110061#
kinetic law: MODEL1310110061#

metaM ala B e
boundary condition: false
initial amount: NaN
has only substance units: false
notes: FORMULA: C3H7NO2 CHARGE: 0 INCHI: InChI=1S/C3H7NO2/c4-2-1-3(5)6/h1-2,4H2,(H,5,6) HEPATONET_1.0_ABBREVIATION: HC00100
is: HMDB00056
constant: false
is: CHEBI:16958
is: SBO:0000247
name: beta-alanine
type: Species
initial concentration: 1.0

metaM cmpacna n
notes: FORMULA: C20H29N4O16P CHARGE: -2 INCHI: InChI=1S/C20H31N4O16P/c1-7(26)22-12-8(27)4-20(18(32)33,39-16(12)13(29)9(28)5-25)40-41(35,36)37-6-10-14(30)15(31)17(38-10)24-3-2-11(21)23-19(24)34/h2-3,8-10,12-17,25,27-31H,4-6H2,1H3,(H,22,26)(H,32,33)(H,35,36)(H2,21,23,34)/p-2/t8-,9+,10+,12+,13+,14+,15+,16+,17+,20+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00126 EHMN_ABBREVIATION: C00128
is: SBO:0000247
boundary condition: false
is: HMDB01176
initial amount: NaN
type: Species
initial concentration: 1.0
has only substance units: false
name: CMP-N-acetyl-beta-neuraminate(2-)
is: CHEBI:57812
constant: false

http://identifiers.org/biomodels.db/MODEL1310110061#_6f8e923d_6458_451b_8ca5_1ec4b55c577c
boundary condition: true
has only substance units: false
type: Species
is encoded by: hsa:3099
name: HK2
is: P52789
initial amount: NaN
constant: false
initial concentration: NaN
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110061#_028cb3d1_9226_4729_8c20_5f8fcc967b93
initial amount: NaN
is: SBO:0000252
is: Q308M7
initial concentration: NaN
boundary condition: true
has only substance units: false
type: Species
name: ENPP3
is encoded by: hsa:5169
constant: false

metaM dcamp c
initial concentration: 1.0
is: HMDB00536
constant: false
notes: FORMULA: C14H14N5O11P CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC01183 EHMN_ABBREVIATION: C03794
is: SBO:0000247
is: C03794
type: Species
name: N6-(1,2-Dicarboxyethyl)-AMP
has only substance units: false
is: CHEBI:57567
initial amount: NaN
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110061#_24555f90_de90_4836_8102_6e6ac6f59722
type: Species
is: Q05C14
name: FOLR3
has only substance units: false
is: SBO:0000252
constant: false
boundary condition: true
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:2352

metaR r2032
reactant: MODEL1310110061#
fast: false
is: SBO:0000185
modifier: MODEL1310110061#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.15
reversible: false
kinetic law: MODEL1310110061#
type: Reaction
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is described by: ECO:0000000
product: MODEL1310110061#

metaM Lcystin c
is: SBO:0000247
notes: FORMULA: C6H12N2O4S2 CHARGE: 0 INCHI: InChI=1S/C6H12N2O4S2/c7-3(5(9)10)1-13-14-2-4(8)6(11)12/h3-4H,1-2,7-8H2,(H,9,10)(H,11,12)/t3-,4-/m0/s1
is: HMDB00192
is: CHEBI:16283
constant: false
initial amount: NaN
initial concentration: 1.0
type: Species
boundary condition: false
has only substance units: false
name: L-cystine

http://identifiers.org/biomodels.db/MODEL1310110061#_cfe944c2_2526_4f60_9ace_b2ea7dbe0d42
constant: false
is: SBO:0000252
name: GALNT13
type: Species
initial concentration: NaN
is: Q8IUC8
initial amount: NaN
is encoded by: hsa:114805
boundary condition: true
has only substance units: false

metaR r0390
product: MODEL1310110061#
kinetic law: MODEL1310110061#
reversible: true
type: Reaction
name: Isomaltose 6-alpha-D-glucanohydrolase Starch and sucrose metabolism EC:3.2.1.10
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 3.2.1.10 Confidence Level: 0 AUTHORS: PMID:17194452 NOTES:
fast: false
reactant: MODEL1310110061#
is: SBO:0000176
is described by: ECO:0000000

metaR CYSTS
notes: GENE_ASSOCIATION: (875.1) SUBSYSTEM: Methionine and cysteine metabolism EC Number: 4.2.1.22 Confidence Level: 4 AUTHORS: PMID:681363,PMID:9790750 NOTES:NCD
reversible: false
kinetic law: MODEL1310110061#
is version of: http://identifiers.org/ec-code/4.2.1.22
reactant: MODEL1310110061#
name: cystathionine beta-synthase
type: Reaction
product: MODEL1310110061#
modifier: MODEL1310110061#
is described by: ECO:0000269
is: SBO:0000176
fast: false

metaR S6TASE22ly
is version of: http://identifiers.org/ec-code/3.1.6.4
is version of: http://identifiers.org/ec-code/3.2.1.18
type: Reaction
is version of: http://identifiers.org/ec-code/3.2.1.23
product: MODEL1310110061#
reactant: MODEL1310110061#
reversible: true
kinetic law: MODEL1310110061#
is: SBO:0000176
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.1.6.4 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD
name: galactose-6-sulfate sulfatase, lysosomal
modifier: MODEL1310110061#
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/3.4.16.5
fast: false

metaR GHMT2r
fast: false
name: glycine hydroxymethyltransferase, reversible
reactant: MODEL1310110061#
notes: GENE_ASSOCIATION: (6470.1) or (6470.2) SUBSYSTEM: Glycine, serine, alanine and threonine metabolism EC Number: 2.1.2.1 Confidence Level: 4 AUTHORS: PMID:8505317,PMID:8611185,PMID:9038835 NOTES:NCD
modifier: MODEL1310110061#
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/2.1.2.1
is: SBO:0000176
product: MODEL1310110061#
kinetic law: MODEL1310110061#
type: Reaction
reversible: true

metaR GTHRDt
type: Reaction
fast: false
is: SBO:0000185
reactant: MODEL1310110061#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Glutathione metabolism EC Number: Confidence Level: 2 AUTHORS: NOTES:TV (8-15-2003) Meister, A, Mitochondrial changes associated with glutathione deficiency, Biochimica et Biophysica Acta 1271 (1995) 35-42. The article reports that this is an active transport but doesn't not specify if it uses atp.
reversible: true
name: Glutathione transport into mitochondria
kinetic law: MODEL1310110061#
product: MODEL1310110061#

http://identifiers.org/biomodels.db/MODEL1310110061#_662fd116_310c_442d_97ee_08d693076748
is: P07864
initial amount: NaN
is encoded by: hsa:3948
boundary condition: true
name: LDHC
is: SBO:0000252
has only substance units: false
initial concentration: NaN
type: Species
constant: false

metaM succ m
notes: FORMULA: C4H4O4 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00049 EHMN_ABBREVIATION: C00042
is: HMDB00254
is: SBO:0000247
name: Succinate
initial amount: NaN
initial concentration: 1.0
boundary condition: false
is: C00042
constant: false
is: CHEBI:30031
type: Species
has only substance units: false

metaM octa c
has only substance units: false
name: octanoate (n-C8:0)
is: SBO:0000247
initial concentration: 1.0
notes: FORMULA: C8H15O2 CHARGE: -1
is: CHEBI:25646
boundary condition: false
is: C06423
is: HMDB00482
constant: false
type: Species
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110061#_71aa45b6_dc26_46ff_9f27_c551f2fec0e9
constant: false
type: Species
name: HADH
is: SBO:0000252
boundary condition: true
has only substance units: false
is encoded by: hsa:3033
initial concentration: NaN
initial amount: NaN
is: Q16836

http://identifiers.org/biomodels.db/MODEL1310110061#_a445b6f0_f854_4b99_a313_6a56bf1c1f60
is: SBO:0000252
name: SLC6A3
initial amount: NaN
boundary condition: true
is: Q01959
has only substance units: false
is encoded by: hsa:6531
constant: false
type: Species
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110061#_19ac85a9_58fc_4666_9b9f_bcc183a8c878
is: GO:0005615
is: SBO:0000290
constant: false
size: 1.0
spatial dimensions: 3.0
name: extracellular space
type: Compartment

metaM datp n
is: HMDB01532
is: CHEBI:61404
has only substance units: false
initial concentration: 1.0
initial amount: NaN
notes: FORMULA: C10H12N5O12P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00129 EHMN_ABBREVIATION: C00131
is: SBO:0000247
boundary condition: false
is: C00131
type: Species
constant: false
name: dATP

metaM 5eipencoa m
constant: false
initial concentration: 1.0
is: HMDB02288
has only substance units: false
boundary condition: false
name: 5,8,11,14,17-eicosapentenoylcoa
notes: FORMULA: C41H60N7O17P3S CHARGE: -4
is: SBO:0000247
initial amount: NaN
type: Species

metaM coa x
boundary condition: false
constant: false
has only substance units: false
initial concentration: 1.0
is: HMDB01423
type: Species
initial amount: NaN
is: CHEBI:57287
notes: FORMULA: C21H32N7O16P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00020 EHMN_ABBREVIATION: C00010
is: SBO:0000247
is: C00010
name: Coenzyme A

metaM malthx e
has only substance units: false
is: C01936
notes: FORMULA: C36H62O31 CHARGE: 0 INCHI: InChI=1/C36H62O31/c37-1-7-13(43)14(44)21(51)32(58-7)64-27-9(3-39)60-34(23(53)16(27)46)66-29-11(5-41)62-36(25(55)18(29)48)67-30-12(6-42)61-35(24(54)19(30)49)65-28-10(4-40)59-33(22(52)17(28)47)63-26-8(2-38)57-31(56)20(50)15(26)45/h7-56H,1-6H2/t7-,8-,9-,10-,11-,12-,13-,14+,15-,16-,17-,18-,19-,20-,21-,22-,23-,24-,25-,26-,27-,28-,29-,30-,31?,32-,33-,34-,35-,36-/m1/s1 EHMN_ABBREVIATION: C01936
is: SBO:0000247
type: Species
name: Maltohexaose
initial concentration: 1.0
boundary condition: false
constant: false
is: http://identifiers.org/pubchem.compound/5041
initial amount: NaN

metaM Lkynr c
is: CHEBI:16946
has only substance units: false
constant: false
is: SBO:0000247
boundary condition: false
notes: FORMULA: C10H12N2O3 CHARGE: 0 INCHI: InChI=1S/C10H12N2O3/c11-7-4-2-1-3-6(7)9(13)5-8(12)10(14)15/h1-4,8H,5,11-12H2,(H,14,15)/t8-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00278 EHMN_ABBREVIATION: C00328
initial amount: NaN
type: Species
name: L-kynurenine
initial concentration: 1.0
is: HMDB00684

metaM lneldc c
initial concentration: 1.0
is: HMDB06270
name: linoelaidic acid (all trans C18:2)
boundary condition: false
type: Species
has only substance units: false
is: SBO:0000247
initial amount: NaN
notes: FORMULA: C18H31O2 CHARGE: -1 INCHI: InChI=1/C18H32O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20/h6-7,9-10H,2-5,8,11-17H2,1H3,(H,19,20)/b7-6+,10-9+
constant: false

metaM cgly e
is: CHEBI:4047
name: L-cysteinylglycine
has only substance units: false
boundary condition: false
initial amount: NaN
is: SBO:0000247
type: Species
constant: false
is: HMDB00078
initial concentration: 1.0
notes: FORMULA: C5H10N2O3S CHARGE: 0 INCHI: InChI=1S/C5H10N2O3S/c6-3(2-11)5(10)7-1-4(8)9/h3,11H,1-2,6H2,(H,7,10)(H,8,9)/t3-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00784 EHMN_ABBREVIATION: C01419

metaR GLNtm
type: Reaction
name: L-glutamine transport via electroneutral transporter
is described by: ECO:0000000
kinetic law: MODEL1310110061#
reactant: MODEL1310110061#
reversible: false
product: MODEL1310110061#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: NOTES:TV (6/7/2005) Study in rat liver (Soboll, 1991)
fast: false

http://identifiers.org/biomodels.db/MODEL1310110061#_4b2db11c_4208_441f_81b0_9598029d10ff
initial amount: NaN
type: Species
boundary condition: true
is encoded by: hsa:375056
is: SBO:0000252
name: MIA3
is: Q5JRA6
constant: false
initial concentration: NaN
has only substance units: false

metaR r0393
reversible: false
fast: false
is: SBO:0000176
is described by: ECO:0000000
reactant: MODEL1310110061#
notes: GENE_ASSOCIATION: (1633.1) SUBSYSTEM: Unassigned EC Number: 1.2.1.3 Confidence Level: 0 AUTHORS: PMID:12705826,PMID:170276,PMID:6189823,PMID:6285247,PMID:8155713 NOTES:
is version of: http://identifiers.org/ec-code/2.7.1.74
name: D-Glyceraldehyde:NAD+ oxidoreductase Glycerolipid metabolism EC:1.2.1.3
product: MODEL1310110061#
type: Reaction
modifier: MODEL1310110061#
kinetic law: MODEL1310110061#

metaR DOLGLCP Lter
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: N-glycan synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:12137737 NOTES:
name: Dolichyl beta-D-glucosyl phosphate flippase (liver)
product: MODEL1310110061#
kinetic law: MODEL1310110061#
reactant: MODEL1310110061#
is: SBO:0000185
reversible: false
type: Reaction
fast: false

http://identifiers.org/biomodels.db/MODEL1310110061#_64642f5a_0295_40f9_ba04_bf94bff136f9
has only substance units: false
is encoded by: hsa:51
is: Q15067
boundary condition: true
constant: false
initial amount: NaN
name: ACOX1
type: Species
initial concentration: NaN
is: SBO:0000252

metaR r0726
notes: GENE_ASSOCIATION: (AI924226.1) or (53354.1) or (80025.1) or (79646.1) or (55229.1) or (100128062.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.1.1.35 Confidence Level: 0 AUTHORS: PMID:10231530,PMID:10329704,PMID:1550553,PMID:1651711,PMID:7150615,PMID:8188243,PMID:8687463,PMID:9553139 NOTES:
is: SBO:0000176
modifier: MODEL1310110061#
is version of: http://identifiers.org/ec-code/2.7.1.33
is described by: ECO:0000000
type: Reaction
name: (S)-Hydroxydecanoyl-CoA:NAD+ oxidoreductase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:1.1.1.35 EC:1.1.1.211
product: MODEL1310110061#
fast: false
reactant: MODEL1310110061#
kinetic law: MODEL1310110061#
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110061#_6aaa3b8a_2cc4_407c_8fe3_8f52793544f0
is: SBO:0000252
name: GALNT3
constant: false
type: Species
initial concentration: NaN
is: Q14435
has only substance units: false
is encoded by: hsa:2591
boundary condition: true
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110061#_d86c3359_32b3_477b_b0a4_5df52efabfde
is: P21217
is encoded by: hsa:2525
name: FUT3
initial concentration: NaN
is: SBO:0000252
initial amount: NaN
has only substance units: false
type: Species
boundary condition: true
constant: false

http://identifiers.org/biomodels.db/MODEL1310110061#_d5b562ab_02e4_4d1d_b1a4_a399b0e4a5ba
initial amount: NaN
initial concentration: NaN
constant: false
is encoded by: hsa:60490
is: Q96CD2
has only substance units: false
boundary condition: true
is: SBO:0000252
type: Species
name: PPCDC

http://identifiers.org/biomodels.db/MODEL1310110061#_fca5a3fe_dadf_4c2c_a0d2_becb16d323f5
is: SBO:0000252
initial amount: NaN
initial concentration: NaN
name: LDHA
boundary condition: true
type: Species
has only substance units: false
is encoded by: hsa:3939
constant: false
is: P00338

http://identifiers.org/biomodels.db/MODEL1310110061#_ac8b2213_e035_48d5_91f8_5facba8617fe
is: SBO:0000252
type: Species
constant: false
initial amount: NaN
has only substance units: false
boundary condition: true
initial concentration: NaN
is: B7Z1R0
is encoded by: hsa:57282
name: SLC4A10

metaR FAOXC204C184m
kinetic law: MODEL1310110061#
product: MODEL1310110061#
reactant: MODEL1310110061#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C20:4-->C18:4)m
type: Reaction

metaR FUCFUCGALACGLCGALGLUSIDEtg
product: MODEL1310110061#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 2 AUTHORS: NOTES:unknown mechanism, however these blood groups need to make it to the extracellular surface of cells NJ
type: Reaction
kinetic law: MODEL1310110061#
reactant: MODEL1310110061#
fast: false
is described by: ECO:0000000
name: blood group intracellular transport
is: SBO:0000185
reversible: true

metaM pail45p hs m
notes: FORMULA: C9H14O15P3FULLRCO2FULLR2CO2 CHARGE: -5 EHMN_ABBREVIATION: C04637
type: Species
is: SBO:0000247
constant: false
name: phosphatidylinositol 4,5-bisphosphate
boundary condition: false
has only substance units: false
initial concentration: 1.0
is: CHEBI:28910
initial amount: NaN

metaM ala B c
boundary condition: false
has only substance units: false
notes: FORMULA: C3H7NO2 CHARGE: 0 INCHI: InChI=1S/C3H7NO2/c4-2-1-3(5)6/h1-2,4H2,(H,5,6) HEPATONET_1.0_ABBREVIATION: HC00100
initial amount: NaN
name: beta-alanine
is: HMDB00056
is: CHEBI:16958
constant: false
type: Species
initial concentration: 1.0
is: SBO:0000247

metaM sph1p c
boundary condition: false
has only substance units: false
initial concentration: 1.0
constant: false
type: Species
is: SBO:0000247
name: (2S,3R)-2-azaniumyl-3-hydroxyoctadecyl phosphate
initial amount: NaN
notes: FORMULA: C18H39NO5P CHARGE: -1 INCHI: InChI=1S/C18H40NO5P/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-18(20)17(19)16-24-25(21,22)23/h17-18,20H,2-16,19H2,1H3,(H2,21,22,23)/p-1/t17-,18+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00675 EHMN_ABBREVIATION: C01120
is: CHEBI:57939
is: HMDB01383

metaR RDH1
fast: false
kinetic law: MODEL1310110061#
is described by: ECO:0000269
reactant: MODEL1310110061#
is version of: http://identifiers.org/ec-code/1.1.1.315
modifier: MODEL1310110061#
reversible: true
name: retinol dehydrogenase (all-trans)
product: MODEL1310110061#
is: SBO:0000176
notes: GENE_ASSOCIATION: (5959.1) or (8608.1) SUBSYSTEM: Vitamin A metabolism EC Number: 1.1.1.105 Confidence Level: 4 AUTHORS: PMID:10329026,PMID:12226107,PMID:12534290,PMID:1503811 NOTES:IT
type: Reaction

metaM Lcystin e
initial amount: NaN
type: Species
is: SBO:0000247
notes: FORMULA: C6H12N2O4S2 CHARGE: 0 INCHI: InChI=1S/C6H12N2O4S2/c7-3(5(9)10)1-13-14-2-4(8)6(11)12/h3-4H,1-2,7-8H2,(H,9,10)(H,11,12)/t3-,4-/m0/s1
boundary condition: false
has only substance units: false
name: L-cystine
initial concentration: 1.0
constant: false
is: CHEBI:16283
is: HMDB00192

metaR RETI1
kinetic law: MODEL1310110061#
fast: false
reversible: true
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Vitamin A metabolism EC Number: 5.2.1.7 Confidence Level: 2 AUTHORS: PMID:1503811 NOTES:IT
is: SBO:0000176
reactant: MODEL1310110061#
product: MODEL1310110061#
is described by: ECO:0000000
name: retinol isomerase (11-cis)

metaR r0392
name: D-Glyceraldehyde:NAD+ oxidoreductase Glycerolipid metabolism EC:1.2.1.3
product: MODEL1310110061#
type: Reaction
kinetic law: MODEL1310110061#
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 1.2.1.3 Confidence Level: 0 AUTHORS: PMID:12705826,PMID:170276,PMID:6189823,PMID:6285247,PMID:8155713 NOTES:
is: SBO:0000176
fast: false
is described by: ECO:0000000
reactant: MODEL1310110061#

metaM ach e
initial concentration: 1.0
name: acetylcholine
notes: FORMULA: C7H16NO2 CHARGE: 1 INCHI: InChI=1S/C7H16NO2/c1-7(9)10-6-5-8(2,3)4/h5-6H2,1-4H3/q+1 HEPATONET_1.0_ABBREVIATION: HC00877 EHMN_ABBREVIATION: C01996
constant: false
type: Species
is: CHEBI:15355
is: HMDB00895
is: SBO:0000247
has only substance units: false
initial amount: NaN
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110061#_36c5bea0_a7a1_49e9_bf9c_1af8020e1a45
is: SBO:0000252
has only substance units: false
is encoded by: hsa:1119
initial amount: NaN
initial concentration: NaN
name: CHKA
boundary condition: true
constant: false
type: Species

metaR r0502
modifier: MODEL1310110061#
kinetic law: MODEL1310110061#
fast: false
is version of: http://identifiers.org/ec-code/2.7.1.113
is: SBO:0000176
name: xanthine:NAD+ oxidoreductase Purine metabolism EC:1.17.1.4
reversible: true
notes: GENE_ASSOCIATION: (1716.1) or (NM_001929.1) SUBSYSTEM: Purine catabolism EC Number: 1.17.1.4 Confidence Level: 0 AUTHORS: PMID:11246119,PMID:12632927 NOTES:
type: Reaction
is described by: ECO:0000000
reactant: MODEL1310110061#
product: MODEL1310110061#

metaM octa e
has only substance units: false
is: SBO:0000247
name: octanoate (n-C8:0)
initial concentration: 1.0
is: CHEBI:25646
constant: false
is: C06423
is: HMDB00482
boundary condition: false
notes: FORMULA: C8H15O2 CHARGE: -1
type: Species
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110061#_b46d8180_a228_4218_b3eb_a447a2697e42
has only substance units: false
constant: false
type: Species
name: _728637_1_c
is encoded by: hsa:728637
initial concentration: NaN
is: SBO:0000252
initial amount: NaN
boundary condition: true

metaR EX amp LPAREN e RPAREN
kinetic law: MODEL1310110061#
reactant: MODEL1310110061#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: AMP exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110061#_f48fff53_1bcc_4978_ac93_75e387cc0635
is: SBO:0000297
name: VNN3:VNN2:VNN1
constant: false
is encoded by: hsa:8875
type: Species
initial amount: NaN
has part: O95498
boundary condition: true
initial concentration: NaN
has only substance units: false
is encoded by: hsa:55350

http://identifiers.org/biomodels.db/MODEL1310110061#_a348ae54_c34c_4e8d_bfb2_e5ccf6bc8200
is encoded by: hsa:3101
is: P52790
initial amount: NaN
has only substance units: false
constant: false
name: HK3
type: Species
is: SBO:0000252
initial concentration: NaN
boundary condition: true

metaR r2034
is: SBO:0000185
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
modifier: MODEL1310110061#
reversible: false
reactant: MODEL1310110061#
type: Reaction
product: MODEL1310110061#
kinetic law: MODEL1310110061#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.15
fast: false
is described by: ECO:0000000

metaM pail45p hs n
is: CHEBI:28910
constant: false
has only substance units: false
notes: FORMULA: C9H14O15P3FULLRCO2FULLR2CO2 CHARGE: -5 EHMN_ABBREVIATION: C04637
initial amount: NaN
boundary condition: false
name: phosphatidylinositol 4,5-bisphosphate
initial concentration: 1.0
type: Species
is: SBO:0000247

metaM HC02175 e
constant: false
type: Species
boundary condition: false
is: CHEBI:27689
notes: FORMULA: C10H19O2 CHARGE: -1 INCHI: InChI=1S/C10H20O2/c1-2-3-4-5-6-7-8-9-10(11)12/h2-9H2,1H3,(H,11,12)/p-1
name: caprate
initial concentration: 1.0
initial amount: NaN
has only substance units: false
is: SBO:0000247

metaR RDH2
type: Reaction
product: MODEL1310110061#
reactant: MODEL1310110061#
notes: GENE_ASSOCIATION: (5959.1) SUBSYSTEM: Vitamin A metabolism EC Number: 1.1.1.105 Confidence Level: 4 AUTHORS: PMID:12226107,PMID:1503811,PMID:7836368,PMID:9115228 NOTES:IT
modifier: MODEL1310110061#
kinetic law: MODEL1310110061#
is version of: http://identifiers.org/ec-code/1.1.1.315
name: retinol dehydrogenase (9-cis,NADH)
fast: false
reversible: true
is described by: ECO:0000269
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110061#_5cf7daff_f800_4f98_8753_67631bcd2e6b
constant: false
name: SLC5A2
is encoded by: hsa:6524
is: SBO:0000252
has only substance units: false
initial concentration: NaN
initial amount: NaN
is: P31639
type: Species
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110061#_1d91a7d7_7a97_4d8f_87fe_632280da2bc1
constant: false
initial amount: NaN
name: ALDH3A1
type: Species
boundary condition: true
initial concentration: NaN
is encoded by: hsa:218
is: SBO:0000252
has only substance units: false
is: P30838

metaR r0317
is version of: http://identifiers.org/ec-code/2.1.2.10
reactant: MODEL1310110061#
is version of: http://identifiers.org/ec-code/1.4.4.2
fast: false
product: MODEL1310110061#
is version of: http://identifiers.org/ec-code/1.8.1.4
is described by: ECO:0000000
reversible: true
name: citrate hydro-lyase Citrate cycle (TCA cycle) / Glyoxylate and dicarboxylate metabolism EC:4.2.1.4
type: Reaction
is: SBO:0000176
kinetic law: MODEL1310110061#
modifier: MODEL1310110061#
notes: GENE_ASSOCIATION: (AI761708.1) or (275.1) or (1738.1) or (2731.1) SUBSYSTEM: Unassigned EC Number: 4.2.1.4 Confidence Level: 0 AUTHORS: PMID:15263083,PMID:16511074 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110061#_4453070d_acfe_4b7f_a92b_e9728f55f635
is: SBO:0000252
has only substance units: false
is encoded by: hsa:8608
initial concentration: NaN
type: Species
name: RDH16
boundary condition: true
is: O75452
initial amount: NaN
constant: false

metaR FERO
product: MODEL1310110061#
is: SBO:0000176
modifier: MODEL1310110061#
is described by: ECO:0000134
type: Reaction
fast: false
name: ferroxidase
notes: GENE_ASSOCIATION: (9843.1) SUBSYSTEM: Vitamin B2 metabolism EC Number: Confidence Level: 4 AUTHORS: Sareen S. Gropper, Jack L. Smith, James L. Groff (2009) Advanced nutrition and human metabolism, Wadsworth cengage learning, 5th edition, page 472-476. NOTES:
reversible: false
reactant: MODEL1310110061#
kinetic law: MODEL1310110061#

metaR r1540
modifier: MODEL1310110061#
kinetic law: MODEL1310110061#
notes: GENE_ASSOCIATION: (BE966236.1) or (6240.1) or (6241.1) or (50484.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12719981 NOTES:
product: MODEL1310110061#
name: Neurotransmitter:Sodium Symporter (NSS) TCDB:2.A.22.3.3
is: SBO:0000185
is described by: ECO:0000000
fast: false
type: Reaction
reactant: MODEL1310110061#
reversible: false
is version of: http://identifiers.org/ec-code/1.17.4.1

metaM C05280 m
initial amount: NaN
constant: false
boundary condition: false
type: Species
has only substance units: false
is: HMDB03952
is: CHEBI:28002
name: cis,cis-3,6-Dodecadienoyl-CoA
is: SBO:0000247
notes: FORMULA: C33H50N7O17P3S CHARGE: -4 INCHI: InChI=1S/C33H54N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-24(42)61-17-16-35-23(41)14-15-36-31(45)28(44)33(2,3)19-54-60(51,52)57-59(49,50)53-18-22-27(56-58(46,47)48)26(43)32(55-22)40-21-39-25-29(34)37-20-38-30(25)40/h8-9,11-12,20-22,26-28,32,43-44H,4-7,10,13-19H2,1-3H3,(H,35,41)(H,36,45)(H,49,50)(H,51,52)(H2,34,37,38)(H2,46,47,48)/b9-8-,12-11-/t22-,26-,27-,28+,32-/m1/s1 EHMN_ABBREVIATION: C05280
initial concentration: 1.0

metaM CE2420 m
constant: false
is: HMDB11123
initial concentration: 1.0
has only substance units: false
type: Species
is: SBO:0000247
boundary condition: false
initial amount: NaN
is: CHEBI:28387
name: (3S)-3-hydroxydodec-cis-6-enoyl-CoA
notes: FORMULA: C33H52N7O18P3S CHARGE: -4 INCHI: InChI=1/C33H56N7O18P3S/c1-4-5-6-7-8-9-10-11-21(41)16-24(43)62-15-14-35-23(42)12-13-36-31(46)28(45)33(2,3)18-55-61(52,53)58-60(50,51)54-17-22-27(57-59(47,48)49)26(44)32(56-22)40-20-39-25-29(34)37-19-38-30(25)40/h8-9,19-22,26-28,32,41,44-45H,4-7,10-18H2,1-3H3,(H,35,42)(H,36,46)(H,50,51)(H,52,53)(H2,34,37,38)(H2,47,48,49)/p-4/b9-8-/t21-,22-,26+,27+,28u,32-/m0/s1 EHMN_ABBREVIATION: CE2420

metaR r2439
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12759755 NOTES:
product: MODEL1310110061#
kinetic law: MODEL1310110061#
reactant: MODEL1310110061#
type: Reaction
reversible: false
is: SBO:0000185
name: Zinc (Zn2+)-Iron (Fe2+) Permease (ZIP), TCDB:2.A.53.2.2
fast: false
is described by: ECO:0000000

metaR r1653
reversible: true
product: MODEL1310110061#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is described by: ECO:0000000
kinetic law: MODEL1310110061#
type: Reaction
fast: false
is: SBO:0000185
reactant: MODEL1310110061#
modifier: MODEL1310110061#
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:

metaM coa n
is: CHEBI:57287
is: HMDB01423
type: Species
boundary condition: false
notes: FORMULA: C21H32N7O16P3S CHARGE: -4 INCHI: InChI=1S/C21H36N7O16P3S/c1-21(2,16(31)19(32)24-4-3-12(29)23-5-6-48)8-41-47(38,39)44-46(36,37)40-7-11-15(43-45(33,34)35)14(30)20(42-11)28-10-27-13-17(22)25-9-26-18(13)28/h9-11,14-16,20,30-31,48H,3-8H2,1-2H3,(H,23,29)(H,24,32)(H,36,37)(H,38,39)(H2,22,25,26)(H2,33,34,35)/p-4/t11-,14-,15-,16+,20-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00020 EHMN_ABBREVIATION: C00010
has only substance units: false
name: coenzyme A(4-)
constant: false
is: SBO:0000247
initial concentration: 1.0
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110061#_623e139b_acf0_4131_8544_11ad042ce716
is: SBO:0000252
name: SGPP1
is encoded by: hsa:81537
has only substance units: false
initial amount: NaN
is: Q9BX95
initial concentration: NaN
type: Species
constant: false
boundary condition: true

metaR GALSGLT1le
kinetic law: MODEL1310110061#
product: MODEL1310110061#
reactant: MODEL1310110061#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of D-Galactose from extracellular space to cytosol of mucosal cells in small intestine
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110061#_cf1accca_c936_4e78_a282_5b25c740aa44
name: SDR16C5
constant: false
is: SBO:0000252
is encoded by: hsa:195814
type: Species
boundary condition: true
initial amount: NaN
has only substance units: false
is: B3KT84
initial concentration: NaN

metaR STRDNCt
is described by: ECO:0000000
name: fatty acid transport via diffusion
reactant: MODEL1310110061#
is: SBO:0000185
reversible: true
fast: false
product: MODEL1310110061#
kinetic law: MODEL1310110061#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11788354,PMID:12864740 NOTES:NJ
type: Reaction

metaR FRUt4
reactant: MODEL1310110061#
fast: false
kinetic law: MODEL1310110061#
is: SBO:0000185
notes: GENE_ASSOCIATION: (200010.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12748858,PMID:15607332 NOTES:NCD
reversible: true
is described by: ECO:0000269
type: Reaction
modifier: MODEL1310110061#
name: D-fructose transport via sodium cotransport
product: MODEL1310110061#

http://identifiers.org/biomodels.db/MODEL1310110061#_29c3aaa2_1506_4d9f_9067_edb0d372b3a0
has only substance units: false
is: SBO:0000252
constant: false
name: B3GNT5
initial concentration: NaN
boundary condition: true
is: Q9BYG0
is encoded by: hsa:84002
initial amount: NaN
type: Species

http://identifiers.org/biomodels.db/MODEL1310110061#_bf7dc665_b92f_472c_afa2_9323f40e9671
type: Species
is encoded by: hsa:10423
initial concentration: NaN
has only substance units: false
is: SBO:0000252
name: CDIPT
initial amount: NaN
boundary condition: true
constant: false
is: O14735

http://identifiers.org/biomodels.db/MODEL1310110061#_e533a5b8_0326_47f8_bd6b_067cdf3504a3
is: G0W2N5
name: SLC14A1
initial concentration: NaN
constant: false
boundary condition: true
is encoded by: hsa:6563
has only substance units: false
is: SBO:0000252
initial amount: NaN
type: Species

metaR NODe
is: SBO:0000185
type: Reaction
product: MODEL1310110061#
name: NODe
fast: false
is described by: ECO:0000134
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
reversible: true
kinetic law: MODEL1310110061#
reactant: MODEL1310110061#

metaR r0870
is version of: http://identifiers.org/ec-code/3.1.3.4
is version of: http://identifiers.org/ec-code/3.6.4.13
reactant: MODEL1310110061#
type: Reaction
product: MODEL1310110061#
is: SBO:0000185
is version of: http://identifiers.org/ec-code/2.7.7.72
name: Facilitated diffusion
fast: false
reversible: true
is described by: ECO:0000000
modifier: MODEL1310110061#
notes: GENE_ASSOCIATION: (AA419122.1) or (AA576959.1) or (64077.1) or (8776.1) or (8898.1) or (9107.1) or (29085.1) or (8611.1) or (8613.1) or (8612.1) or (81537.1) or (130367.1) or (23517.1) or (51095.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14977409,PMID:17466261 NOTES:
kinetic law: MODEL1310110061#
is version of: http://identifiers.org/ec-code/3.6.1.1

metaM gua c
notes: FORMULA: C5H5N5O CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00219 EHMN_ABBREVIATION: C00242
name: Guanine
is: SBO:0000247
initial amount: NaN
is: CHEBI:16235
initial concentration: 1.0
is: HMDB00132
has only substance units: false
is: C00242
type: Species
boundary condition: false
constant: false

metaM fadh2 m
notes: FORMULA: C27H33N9O15P2 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00770 EHMN_ABBREVIATION: C01352
boundary condition: false
initial concentration: 1.0
constant: false
is: HMDB01197
has only substance units: false
is: C01352
type: Species
initial amount: NaN
is: SBO:0000247
name: Flavin adenine dinucleotide reduced
is: CHEBI:58307

metaR FAOXC163GC142m
kinetic law: MODEL1310110061#
product: MODEL1310110061#
reactant: MODEL1310110061#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C16:3-->C14:2)gm
type: Reaction

metaM ttdca e
has only substance units: false
name: tetradecanoate (n-C14:0)
is: CHEBI:30807
initial concentration: 1.0
notes: FORMULA: C14H27O2 CHARGE: -1 EHMN_ABBREVIATION: C06424
is: SBO:0000247
constant: false
is: HMDB00806
type: Species
initial amount: NaN
is: C06424
boundary condition: false

metaM thbpt c
boundary condition: false
name: 5,6,7,8-tetrahydrobiopterin
has only substance units: false
constant: false
notes: FORMULA: C9H15N5O3 CHARGE: 0 INCHI: InChI=1S/C9H15N5O3/c1-3(15)6(16)4-2-11-7-5(12-4)8(17)14-9(10)13-7/h3-4,6,12,15-16H,2H2,1H3,(H4,10,11,13,14,17) HEPATONET_1.0_ABBREVIATION: HC00245 EHMN_ABBREVIATION: C00272
initial concentration: 1.0
is: HMDB00027
is: SBO:0000247
type: Species
initial amount: NaN
is: CHEBI:15372

metaR r1654
fast: false
is: SBO:0000185
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
modifier: MODEL1310110061#
is described by: ECO:0000000
type: Reaction
reactant: MODEL1310110061#
reversible: true
product: MODEL1310110061#
kinetic law: MODEL1310110061#
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:

metaM tethex3 e
is: HMDB02007
initial concentration: 1.0
boundary condition: false
type: Species
name: tetracosahexaenoic acid, n-3
constant: false
initial amount: NaN
notes: FORMULA: C24H35O2 CHARGE: -1 INCHI: InChI=1/C24H36O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-24(25)26/h3-4,6-7,9-10,12-13,15-18H,2,5,8,11,14,19-23H2,1H3,(H,25,26)/b4-3-,7-6-,10-9-,13-12-,16-15-,18-17-
has only substance units: false
is: SBO:0000247

metaM mmcoa R m
is: CHEBI:57326
has only substance units: false
initial amount: NaN
constant: false
is: HMDB01269
name: (R)-methylmalonyl-CoA(5-)
type: Species
notes: FORMULA: C25H35N7O19P3S CHARGE: -5 INCHI: InChI=1S/C25H40N7O19P3S/c1-12(23(37)38)24(39)55-7-6-27-14(33)4-5-28-21(36)18(35)25(2,3)9-48-54(45,46)51-53(43,44)47-8-13-17(50-52(40,41)42)16(34)22(49-13)32-11-31-15-19(26)29-10-30-20(15)32/h10-13,16-18,22,34-35H,4-9H2,1-3H3,(H,27,33)(H,28,36)(H,37,38)(H,43,44)(H,45,46)(H2,26,29,30)(H2,40,41,42)/p-5/t12-,13-,16-,17-,18+,22-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00721
initial concentration: 1.0
boundary condition: false
is: SBO:0000247

metaM coa m
notes: FORMULA: C21H32N7O16P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00020 EHMN_ABBREVIATION: C00010
initial amount: NaN
is: C00010
type: Species
initial concentration: 1.0
name: Coenzyme A
has only substance units: false
is: CHEBI:57287
is: HMDB01423
boundary condition: false
constant: false
is: SBO:0000247

metaR GAMt1r
reversible: true
kinetic law: MODEL1310110061#
product: MODEL1310110061#
notes: GENE_ASSOCIATION: (6513.1) or (6517.1) or (6514.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:11882499,PMID:12135767,PMID:12750891,PMID:1701966,PMID:2182619,PMID:2656669,PMID:3103217,PMID:3399500,PMID:3839598,PMID:7926364,PMID:9770484 NOTES:
type: Reaction
modifier: MODEL1310110061#
is: SBO:0000185
is described by: ECO:0000269
reactant: MODEL1310110061#
name: glucosamine transport (uniport)
fast: false

metaR EX leuktrE4 LPAREN e RPAREN
kinetic law: MODEL1310110061#
reactant: MODEL1310110061#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: leukotriene E4 exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110061#_db78b5c5_22fd_4fe7_8025_ed0b2f7e0c15
is: SBO:0000252
has only substance units: false
boundary condition: true
initial amount: NaN
is encoded by: hsa:10423
initial concentration: NaN
is: A8K3L7
type: Species
constant: false
name: CDIPT

metaR PPItx
kinetic law: MODEL1310110061#
name: Diphosphate transporter, peroxisome
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 1 AUTHORS: NOTES:diffusion NJ
reactant: MODEL1310110061#
type: Reaction
is: SBO:0000185
is described by: ECO:0000000
product: MODEL1310110061#
fast: false
reversible: true

metaR MERCPLACCYSt
kinetic law: MODEL1310110061#
is: SBO:0000185
reversible: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:excretion of 3-mercaptolactate-cysteine disulfide (PMID: 6945862) MM
name: 3-mercaptolactate-cysteine disulfide transport, extracellular
reactant: MODEL1310110061#
is described by: ECO:0000000
type: Reaction
product: MODEL1310110061#
fast: false

http://identifiers.org/biomodels.db/MODEL1310110061#_85a5ea2c_dc32_4bb1_b85c_29bca88d981a
constant: false
has only substance units: false
boundary condition: true
type: Species
name: TXNRD2
initial amount: NaN
is encoded by: hsa:10587
initial concentration: NaN
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110061#_e7be1e0b_513b_4680_8a22_bf484afc83bf
has only substance units: false
initial concentration: NaN
is: O75752
is encoded by: hsa:8706
is: SBO:0000252
initial amount: NaN
name: B3GALNT1
constant: false
type: Species
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110061#_b6192ffc_35eb_4b1f_8822_55e2fbf0176c
name: PLCG2
initial amount: NaN
is: SBO:0000252
initial concentration: NaN
constant: false
is: P16885
is encoded by: hsa:5336
type: Species
boundary condition: true
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110061#_dae483db_7d35_44c6_9cca_8708222a7e7a
initial amount: NaN
constant: false
is encoded by: hsa:2954
is: A6NED0
boundary condition: true
name: GSTZ1
initial concentration: NaN
has only substance units: false
type: Species
is: SBO:0000252

metaM HC02149 c
name: O-Propanoylcarnitine
notes: FORMULA: C10H19NO4 CHARGE: 0 INCHI: InChI=1S/C10H19NO4/c1-5-10(14)15-8(6-9(12)13)7-11(2,3)4/h8H,5-7H2,1-4H3
initial concentration: 1.0
type: Species
initial amount: NaN
is: CHEBI:28867
boundary condition: false
constant: false
is: SBO:0000247
has only substance units: false

metaM cholate e
is: HMDB00619
name: Cholate
notes: FORMULA: C24H39O5 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00502 EHMN_ABBREVIATION: C00695
is: SBO:0000247
type: Species
has only substance units: false
constant: false
initial amount: NaN
boundary condition: false
is: CHEBI:29747
initial concentration: 1.0

metaM urate x
type: Species
constant: false
is: CHEBI:17775
is: C00366
is: HMDB00289
has only substance units: false
boundary condition: false
initial concentration: 1.0
initial amount: NaN
is: SBO:0000247
name: Urate
notes: FORMULA: C5H4N4O3 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00310 EHMN_ABBREVIATION: C00366

http://identifiers.org/biomodels.db/MODEL1310110061#_8df9598f_a7b4_4538_bec7_1657b6670f9f
has only substance units: false
boundary condition: true
is encoded by: hsa:4696
initial concentration: NaN
is: SBO:0000252
constant: false
name: NDUFA3
initial amount: NaN
is: O95167
type: Species

http://identifiers.org/biomodels.db/MODEL1310110061#_7f6ee4eb_66f4_4766_b618_f2754dc57aa3
is: Q9Y2C5
is encoded by: hsa:10050
initial concentration: NaN
type: Species
initial amount: NaN
boundary condition: true
has only substance units: false
name: SLC17A4
constant: false
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110061#_f38fc1eb_93f9_41e2_8437_8127c473d456
type: Species
has only substance units: false
constant: false
is: Q308M7
boundary condition: true
is encoded by: hsa:5169
initial amount: NaN
name: ENPP3
is: SBO:0000252
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110061#_39358018_b28a_4b37_ae0c_052429b8411b
is encoded by: hsa:84701
boundary condition: true
has only substance units: false
is: SBO:0000252
constant: false
initial amount: NaN
is: Q96KJ9
initial concentration: NaN
type: Species
name: COX4I2

metaR CYSTA
type: Reaction
notes: GENE_ASSOCIATION: (2805.1) SUBSYSTEM: Methionine and cysteine metabolism EC Number: 2.6.1.3 Confidence Level: 2 AUTHORS: PMID:15189131,PMID:7113743 NOTES:MM
is: SBO:0000176
kinetic law: MODEL1310110061#
is version of: http://identifiers.org/ec-code/2.6.1.1
is described by: ECO:0000304
reactant: MODEL1310110061#
reversible: true
fast: false
product: MODEL1310110061#
modifier: MODEL1310110061#
name: cysteine transaminase

metaR PRDX
reactant: MODEL1310110061#
fast: false
notes: GENE_ASSOCIATION: (8288.1) SUBSYSTEM: Miscellaneous EC Number: 1.11.1.7 Confidence Level: 0 AUTHORS: PMID:10464338 NOTES:RS/TV (6/3/05) Peroxidases can act on a variety of substrates which are oxidized, not just methanol.
type: Reaction
reversible: false
is: SBO:0000176
kinetic law: MODEL1310110061#
modifier: MODEL1310110061#
product: MODEL1310110061#
name: Peroxidase (multiple substrates)
is version of: http://identifiers.org/ec-code/1.11.1.7
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110061#_3d3c4a5e_f3e5_4da8_b13f_696273637116
type: Species
is: Q13825
initial concentration: NaN
name: AUH
has only substance units: false
constant: false
initial amount: NaN
is: SBO:0000252
is encoded by: hsa:549
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110061#_a965956b_fbc4_49e0_8761_ad709fd2aed7
is: SBO:0000252
is encoded by: hsa:10870
constant: false
initial concentration: NaN
boundary condition: true
has only substance units: false
initial amount: NaN
is: Q9UBK5
type: Species
name: HCST

metaR FACOAL245 2
fast: false
kinetic law: MODEL1310110061#
is described by: ECO:0000269
product: MODEL1310110061#
is: SBO:0000176
modifier: MODEL1310110061#
reversible: true
reactant: MODEL1310110061#
name: fatty-acid--CoA ligase
type: Reaction
notes: GENE_ASSOCIATION: (2180.1) SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 4 AUTHORS: PMID:15292367 NOTES:NJ
is version of: http://identifiers.org/ec-code/6.2.1.3

metaR ACACt2m
reactant: MODEL1310110061#
fast: false
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (6566.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:28726,PMID:627555 NOTES:IT, TDV changed name from "tm2" to "t2m" - NCD
kinetic law: MODEL1310110061#
name: Acetoacetate mitochondrial transport via H+ symport
is: SBO:0000185
product: MODEL1310110061#
reversible: true
modifier: MODEL1310110061#
type: Reaction

MODEL1310110061#
species: metaM 2octdectecoa m
species: metaM vacc c
species: metaM dhdascb e
species: metaM thf e
species: metaM phe L e
species: metaM acn13acngalgbside hs g
species: metaM dgdp c
stoichiometry: 0.592114
species: metaM prostgf2 e
species: metaM 2hexdtetcoa m
species: metaM galacglcgalgluside hs g
species: metaM fad c
species: metaM vitd3 e
species: metaM 5pmev c
species: metaM glyc m
species: metaM pail hs c
species: metaM pheacgln c
species: metaM 34hpp e
species: metaM mi1p D c
species: metaM dlnlcgcoa c
species: metaM cholcoaone x
stoichiometry: 0.020401
species: metaM ach e
species: metaM crn r
species: metaM ppa c
species: metaM atp c
species: metaM ficytC m
species: metaM s7p c
species: metaM 4mlacac c
species: metaM gam c
species: metaM ppi n
species: metaM 2dp6mobq me m
species: metaM txa2 e
species: metaM n2m2nmn l
species: metaM 5fthf m
species: metaM 4aphdob c
species: metaM tdec4ecoa m
species: metaM mercplaccys c
species: metaM ump g
species: metaM ha e
species: metaM bilirub c
species: metaM nrvnccoa x
species: metaM 4abut n
species: metaM accoa n
species: metaM din e
species: metaM 5adtststerone r
species: metaM gua e
species: metaM 4pyrdx c
stoichiometry: 0.017486
species: metaM vacc e
species: metaM adn c
species: metaM pi n
species: metaM prpp c
species: metaM andrstndn r
species: metaM coa c
species: metaM trdrd c
species: metaM xylt c
species: metaM dectricoa m
species: metaM fadh2 r
species: metaM acglcgalgluside hs g
species: metaM xylu L c
species: metaM 3octpencoa m
species: metaM chtn e
species: metaM ethamp r
stoichiometry: 0.545544
species: metaM fad e
species: metaM udpg r
species: metaM damp c
species: metaM retinol c
species: metaM m2mn l
species: metaM nh4 n
species: metaM HC00250 e
species: metaM 10fthf m
species: metaM pheacgln e
species: metaM chsterol c
species: metaM udpgal e
species: metaM CE2434 m
species: metaM dcsptn1coa x
species: metaM anth e
species: metaM cyst L c

metaR r1655
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is described by: ECO:0000000
type: Reaction
is: SBO:0000185
reversible: true
fast: false
reactant: MODEL1310110061#
kinetic law: MODEL1310110061#
product: MODEL1310110061#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
modifier: MODEL1310110061#

http://identifiers.org/biomodels.db/MODEL1310110061#_e5c7c8ca_1aef_45ef_a9a9_47f0c7cd744d
boundary condition: true
initial concentration: NaN
has only substance units: false
constant: false
type: Species
initial amount: NaN
is: SBO:0000252
is: Q9H6Y6
is encoded by: hsa:4645
name: MYO5B

metaM HC01610 e
constant: false
initial amount: NaN
is: CHEBI:28607
notes: FORMULA: C36H40N4O8 CHARGE: -4 INCHI: InChI=1S/C36H44N4O8/c1-17-21(5-9-33(41)42)29-14-26-19(3)23(7-11-35(45)46)31(39-26)16-28-20(4)24(8-12-36(47)48)32(40-28)15-27-18(2)22(6-10-34(43)44)30(38-27)13-25(17)37-29/h37-40H,5-16H2,1-4H3,(H,41,42)(H,43,44)(H,45,46)(H,47,48) EHMN_ABBREVIATION: C05768
has only substance units: false
boundary condition: false
type: Species
name: CoproporphyrinogenI
is: SBO:0000247
initial concentration: 1.0

metaR DOPAtu
fast: false
type: Reaction
kinetic law: MODEL1310110061#
notes: GENE_ASSOCIATION: (6581.1) or (6582.2) or (6582.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12883891 NOTES:SAB electrogenic, Na indepdendent & rev NJ
product: MODEL1310110061#
modifier: MODEL1310110061#
is described by: ECO:0000269
is: SBO:0000185
reactant: MODEL1310110061#
name: Dopamine uniport
reversible: true

metaM icit m
initial amount: NaN
is: HMDB00193
notes: FORMULA: C6H5O7 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00266 EHMN_ABBREVIATION: C00311
initial concentration: 1.0
is: CHEBI:16087
name: Isocitrate
type: Species
boundary condition: false
constant: false
is: C00311
has only substance units: false
is: SBO:0000247

metaR EX cytd LPAREN e RPAREN
kinetic law: MODEL1310110061#
reactant: MODEL1310110061#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for Cytidine
type: Reaction

metaR UDPGLCter
name: UDP-Glc endoplasmic reticulum transport via CMP antiport
kinetic law: MODEL1310110061#
is: SBO:0000185
reactant: MODEL1310110061#
fast: false
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: PMID:10369669 NOTES:NCD
product: MODEL1310110061#
reversible: true
type: Reaction

metaM hco3 c
type: Species
name: Bicarbonate
is: HMDB00595
constant: false
boundary condition: false
is: CHEBI:17544
notes: FORMULA: CHO3 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00253 EHMN_ABBREVIATION: C00288
is: SBO:0000247
initial amount: NaN
has only substance units: false
is: C00288
initial concentration: 1.0

metaR MTHFD2
is described by: ECO:0000134
is version of: http://identifiers.org/ec-code/3.5.4.9
is: SBO:0000176
notes: GENE_ASSOCIATION: (100287639.1) or (441024.1) SUBSYSTEM: Folate metabolism EC Number: 1.5.1.5 Confidence Level: 2 AUTHORS: PMID:2786332 NOTES:NCD
fast: false
reactant: MODEL1310110061#
kinetic law: MODEL1310110061#
name: methylenetetrahydrofolate dehydrogenase (NAD)
reversible: true
type: Reaction
modifier: MODEL1310110061#
product: MODEL1310110061#

http://identifiers.org/biomodels.db/MODEL1310110061#_603c3795_22ab_4773_b809_1fae366947c5
initial amount: NaN
is encoded by: hsa:211
type: Species
has only substance units: false
name: ALAS1
boundary condition: true
is: SBO:0000252
is: Q5JAM2
constant: false
initial concentration: NaN

metaR r0936
is: SBO:0000185
reactant: MODEL1310110061#
type: Reaction
product: MODEL1310110061#
reversible: false
name: Transport reaction
is described by: ECO:0000000
kinetic law: MODEL1310110061#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
fast: false

metaR MCPST
reactant: MODEL1310110061#
is: SBO:0000176
type: Reaction
is described by: ECO:0000134
fast: false
notes: GENE_ASSOCIATION: (4357.1) SUBSYSTEM: Methionine and cysteine metabolism EC Number: 2.8.1.2 Confidence Level: 4 AUTHORS: PMID:4828222 NOTES:MM AMF. assay developed to find activity in red and white blood cells
kinetic law: MODEL1310110061#
is version of: http://identifiers.org/ec-code/2.8.1.2
name: 3-mercaptopyruvate sulfurtransferase
modifier: MODEL1310110061#
product: MODEL1310110061#
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110061#_e259594d_fee3_4650_bfaf_ff11ca9b265f
has only substance units: false
name: SDHD
constant: false
is encoded by: hsa:6392
initial amount: NaN
is: SBO:0000252
initial concentration: NaN
boundary condition: true
is: O14521
type: Species

metaM apoC m
name: Apocarboxlase (no lys residue)
initial amount: NaN
type: Species
has only substance units: false
is: CHEBI:32551
initial concentration: 1.0
boundary condition: false
is: SBO:0000247
notes: FORMULA: XH CHARGE: 0
is: HMDB00182
constant: false

http://identifiers.org/biomodels.db/MODEL1310110061#_b183f60c_7046_4fa1_bae7_1b660eff5f86
is: Q9NRF8
boundary condition: true
initial concentration: NaN
is: SBO:0000252
initial amount: NaN
name: CTPS2
has only substance units: false
constant: false
is encoded by: hsa:56474
type: Species

metaR AHC
fast: false
is described by: ECO:0000269
is: SBO:0000176
type: Reaction
kinetic law: MODEL1310110061#
is version of: http://identifiers.org/ec-code/3.3.1.1
product: MODEL1310110061#
notes: GENE_ASSOCIATION: (191.1) or (10768.2) or (10768.1) SUBSYSTEM: Methionine and cysteine metabolism EC Number: 3.3.1.1 Confidence Level: 4 AUTHORS: PMID:12590576,PMID:2596825 NOTES:
reversible: true
reactant: MODEL1310110061#
modifier: MODEL1310110061#
name: adenosylhomocysteinase

metaM HC01118 r
initial amount: NaN
boundary condition: false
constant: false
name: presqualene diphosphate(3-)
is: SBO:0000247
notes: FORMULA: C30H49O7P2 CHARGE: -3 INCHI: InChI=1S/C30H52O7P2/c1-23(2)13-9-15-25(5)17-11-18-27(7)21-28-29(22-36-39(34,35)37-38(31,32)33)30(28,8)20-12-19-26(6)16-10-14-24(3)4/h13-14,17,19,21,28-29H,9-12,15-16,18,20,22H2,1-8H3,(H,34,35)(H2,31,32,33)/p-3/b25-17+,26-19+,27-21+/t28-,29-,30-/m0/s1 EHMN_ABBREVIATION: C03428
is: CHEBI:57310
initial concentration: 1.0
type: Species
has only substance units: false

metaM gua e
initial amount: NaN
notes: FORMULA: C5H5N5O CHARGE: 0 INCHI: InChI=1S/C5H5N5O/c6-5-9-3-2(4(11)10-5)7-1-8-3/h1H,(H4,6,7,8,9,10,11) HEPATONET_1.0_ABBREVIATION: HC00219 EHMN_ABBREVIATION: C00242
constant: false
type: Species
name: guanine
is: HMDB00132
has only substance units: false
is: SBO:0000247
initial concentration: 1.0
boundary condition: false
is: CHEBI:16235

metaM HC01231 m
constant: false
is: CHEBI:58480
name: N-[(R)-pantothenoyl]-L-cysteinate
notes: FORMULA: C12H21N2O6S CHARGE: -1 INCHI: InChI=1S/C12H22N2O6S/c1-12(2,6-15)9(17)10(18)13-4-3-8(16)14-7(5-21)11(19)20/h7,9,15,17,21H,3-6H2,1-2H3,(H,13,18)(H,14,16)(H,19,20)/p-1/t7-,9-/m0/s1 EHMN_ABBREVIATION: C04079
has only substance units: false
initial concentration: 1.0
initial amount: NaN
type: Species
is: SBO:0000247
boundary condition: false

metaR FAEL184
type: Reaction
product: MODEL1310110061#
modifier: MODEL1310110061#
reversible: false
name: fatty-acyl-CoA elongation (n-C20:4CoA)
fast: false
notes: GENE_ASSOCIATION: (6785.1) SUBSYSTEM: Fatty acid synthesis EC Number: 2.3.1.86 Confidence Level: 4 AUTHORS: PMID:11138005,PMID:15189125 NOTES:fatty acid elongation step NJ
reactant: MODEL1310110061#
is described by: ECO:0000000
is: SBO:0000176
kinetic law: MODEL1310110061#

http://identifiers.org/biomodels.db/MODEL1310110061#_d78a85cb_e3c6_405e_a549_26fd84958d75
has only substance units: false
is: Q8TCG5
name: CPT1C
constant: false
is: SBO:0000252
boundary condition: true
type: Species
is encoded by: hsa:126129
initial amount: NaN
initial concentration: NaN

metaM utp n
boundary condition: false
initial concentration: 1.0
notes: FORMULA: C9H11N2O15P3 CHARGE: -4 INCHI: InChI=1S/C9H15N2O15P3/c12-5-1-2-11(9(15)10-5)8-7(14)6(13)4(24-8)3-23-28(19,20)26-29(21,22)25-27(16,17)18/h1-2,4,6-8,13-14H,3H2,(H,19,20)(H,21,22)(H,10,12,15)(H2,16,17,18)/p-4/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00077 EHMN_ABBREVIATION: C00075
constant: false
has only substance units: false
is: SBO:0000247
type: Species
initial amount: NaN
is: CHEBI:46398
name: UTP(4-)
is: HMDB00285

http://identifiers.org/biomodels.db/MODEL1310110061#_95eaf38d_be7f_48d6_88f3_1421b98dcdcb
initial concentration: NaN
constant: false
initial amount: NaN
has only substance units: false
type: Species
is: SBO:0000252
name: _AA788780_1_c
boundary condition: true
is encoded by: hsa:AA788780

metaR EX acetone LPAREN e RPAREN
kinetic law: MODEL1310110061#
reactant: MODEL1310110061#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Acetone exchange
type: Reaction

metaR r1656
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
product: MODEL1310110061#
reversible: true
is described by: ECO:0000000
type: Reaction
reactant: MODEL1310110061#
fast: false
is: SBO:0000185
kinetic law: MODEL1310110061#
modifier: MODEL1310110061#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1

http://identifiers.org/biomodels.db/MODEL1310110061#_8309ef88_14bb_45f6_9b56_174192d46124
constant: false
has only substance units: false
type: Species
is: SBO:0000252
is encoded by: hsa:204
initial amount: NaN
name: AK2
is: P54819
boundary condition: true
initial concentration: NaN

metaM ttdca c
initial amount: NaN
name: myristate
initial concentration: 1.0
notes: FORMULA: C14H27O2 CHARGE: -1 INCHI: InChI=1S/C14H28O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14(15)16/h2-13H2,1H3,(H,15,16)/p-1 EHMN_ABBREVIATION: C06424
is: CHEBI:30807
is: SBO:0000247
type: Species
has only substance units: false
boundary condition: false
constant: false
is: HMDB00806

metaM creat c
has only substance units: false
is: SBO:0000247
initial concentration: 1.0
is: HMDB00064
name: creatine
is: CHEBI:16919
type: Species
boundary condition: false
initial amount: NaN
constant: false
notes: FORMULA: C4H9N3O2 CHARGE: 0 INCHI: InChI=1S/C4H9N3O2/c1-7(4(5)6)2-3(8)9/h2H2,1H3,(H3,5,6)(H,8,9) HEPATONET_1.0_ABBREVIATION: HC00260 EHMN_ABBREVIATION: C00300

metaM tethex3 c
initial concentration: 1.0
has only substance units: false
constant: false
name: tetracosahexaenoic acid, n-3
boundary condition: false
is: SBO:0000247
initial amount: NaN
is: HMDB02007
type: Species
notes: FORMULA: C24H35O2 CHARGE: -1 INCHI: InChI=1/C24H36O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-24(25)26/h3-4,6-7,9-10,12-13,15-18H,2,5,8,11,14,19-23H2,1H3,(H,25,26)/b4-3-,7-6-,10-9-,13-12-,16-15-,18-17-

metaM CE2433 m
initial concentration: 1.0
has only substance units: false
is: CHEBI:57795
notes: FORMULA: C37H56N7O17P3S CHARGE: -4 INCHI: InChI=1/C37H60N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-28(46)65-21-20-39-27(45)18-19-40-35(49)32(48)37(2,3)23-58-64(55,56)61-63(53,54)57-22-26-31(60-62(50,51)52)30(47)36(59-26)44-25-43-29-33(38)41-24-42-34(29)44/h8-9,11-12,16-17,24-26,30-32,36,47-48H,4-7,10,13-15,18-23H2,1-3H3,(H,39,45)(H,40,49)(H,53,54)(H,55,56)(H2,38,41,42)(H2,50,51,52)/p-4/b9-8-,12-11-,17-16+/t26-,30+,31+,32u,36-/m0/s1 EHMN_ABBREVIATION: CE2433
name: trans,cis,cis-2,7,10-hexadecatrienoyl-CoA
boundary condition: false
initial amount: NaN
is: SBO:0000247
type: Species
constant: false

metaM ptth c
has only substance units: false
constant: false
name: pantetheine
is: CHEBI:16753
boundary condition: false
initial concentration: 1.0
is: SBO:0000247
is: HMDB03426
notes: FORMULA: C11H22N2O4S CHARGE: 0 INCHI: InChI=1S/C11H22N2O4S/c1-11(2,7-14)9(16)10(17)13-4-3-8(15)12-5-6-18/h9,14,16,18H,3-7H2,1-2H3,(H,12,15)(H,13,17)/t9-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00554 EHMN_ABBREVIATION: C00831
initial amount: NaN
type: Species

metaR r0937
reversible: true
fast: false
reactant: MODEL1310110061#
type: Reaction
product: MODEL1310110061#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
is described by: ECO:0000000
kinetic law: MODEL1310110061#
is: SBO:0000185
name: Transport reaction

metaM lnlncgcoa c
constant: false
boundary condition: false
is: SBO:0000247
is: HMDB06368
notes: FORMULA: C39H60N7O17P3S CHARGE: -4 INCHI: InChI=1S/C39H64N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-30(48)67-23-22-41-29(47)20-21-42-37(51)34(50)39(2,3)25-60-66(57,58)63-65(55,56)59-24-28-33(62-64(52,53)54)32(49)38(61-28)46-27-45-31-35(40)43-26-44-36(31)46/h8-9,11-12,14-15,26-28,32-34,38,49-50H,4-7,10,13,16-25H2,1-3H3,(H,41,47)(H,42,51)(H,55,56)(H,57,58)(H2,40,43,44)(H2,52,53,54)/p-4/b9-8-,12-11-,15-14-/t28-,32-,33-,34+,38-/m1/s1 EHMN_ABBREVIATION: C03035
initial amount: NaN
name: gamma-linolenoyl-CoA(4-)
has only substance units: false
initial concentration: 1.0
is: CHEBI:57363
type: Species

http://identifiers.org/biomodels.db/MODEL1310110061#_563ef8f2_7d22_44ad_9573_11c438c3c0b4
is: SBO:0000252
initial amount: NaN
name: SYNJ2
is encoded by: hsa:8871
constant: false
boundary condition: true
is: O15056
initial concentration: NaN
type: Species
has only substance units: false

metaM glyc m
is: HMDB00131
is: SBO:0000247
type: Species
has only substance units: false
boundary condition: false
initial concentration: 1.0
constant: false
is: C00116
initial amount: NaN
is: CHEBI:17754
notes: FORMULA: C3H8O3 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00114 EHMN_ABBREVIATION: C00116
name: Glycerol

metaR GFUCS
type: Reaction
reversible: false
fast: false
product: MODEL1310110061#
notes: GENE_ASSOCIATION: (7264.1) SUBSYSTEM: Fructose and mannose metabolism EC Number: 1.1.1.271 Confidence Level: 0 AUTHORS: NOTES:Both human and Escherichia coli enzymes can use NADH in place of NADPH to a slight extent. IT
is version of: http://identifiers.org/ec-code/1.1.1.271
modifier: MODEL1310110061#
is described by: ECO:0000000
kinetic law: MODEL1310110061#
is: SBO:0000176
reactant: MODEL1310110061#
name: GDP-L-fucose synthase

metaR BUTt2r
reactant: MODEL1310110061#
modifier: MODEL1310110061#
fast: false
is described by: ECO:0000269
is: SBO:0000185
type: Reaction
name: Butyrate transport via proton symport, reversible
kinetic law: MODEL1310110061#
product: MODEL1310110061#
reversible: true
notes: GENE_ASSOCIATION: (6566.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10510291,PMID:11827462,PMID:12739169,PMID:7835905,PMID:8476015,PMID:9508842,PMID:9649795,PMID:9824713 NOTES:JLR

metaM xol7ah3 m
initial concentration: 1.0
name: 5beta-cholestane-3alpha,7alpha,26-triol
has only substance units: false
is: CHEBI:28540
notes: FORMULA: C27H48O3 CHARGE: 0 INCHI: InChI=1S/C27H48O3/c1-17(16-28)6-5-7-18(2)21-8-9-22-25-23(11-13-27(21,22)4)26(3)12-10-20(29)14-19(26)15-24(25)30/h17-25,28-30H,5-16H2,1-4H3/t17?,18-,19+,20-,21-,22+,23+,24-,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01453 EHMN_ABBREVIATION: C05444
is: HMDB12455
initial amount: NaN
boundary condition: false
constant: false
is: SBO:0000247
type: Species

metaM dhlam m
is: HMDB00985
boundary condition: false
notes: FORMULA: C8H17NOS2 CHARGE: 0 INCHI: InChI=1S/C8H17NOS2/c9-8(10)4-2-1-3-7(12)5-6-11/h7,11-12H,1-6H2,(H2,9,10) HEPATONET_1.0_ABBREVIATION: HC00437 EHMN_ABBREVIATION: C00579
is: SBO:0000247
initial amount: NaN
constant: false
name: dihydrolipoamide
type: Species
is: CHEBI:17694
has only substance units: false
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110061#_6c5c4806_6671_4907_86ea_d2dc96c4d51a
is encoded by: hsa:6307
has only substance units: false
type: Species
constant: false
name: MSMO1
is: A8MYF6
initial concentration: NaN
initial amount: NaN
boundary condition: true
is: SBO:0000252

metaR FAEL183
is: SBO:0000176
kinetic law: MODEL1310110061#
fast: false
type: Reaction
product: MODEL1310110061#
name: fatty-acyl-CoA elongation (n-C18:3CoA)
notes: GENE_ASSOCIATION: (6785.1) SUBSYSTEM: Fatty acid synthesis EC Number: 2.3.1.86 Confidence Level: 4 AUTHORS: PMID:11138005,PMID:15189125 NOTES:fatty acid elongation step NJ
reactant: MODEL1310110061#
is described by: ECO:0000000
modifier: MODEL1310110061#
reversible: false

metaR ASP1DC
kinetic law: MODEL1310110061#
is described by: ECO:0000212
is version of: http://identifiers.org/ec-code/4.1.1.15
reversible: false
type: Reaction
name: aspartate 1-decarboxylase
fast: false
modifier: MODEL1310110061#
is: SBO:0000176
notes: GENE_ASSOCIATION: (2571.1) or (2571.2) SUBSYSTEM: beta-Alanine metabolism EC Number: 4.1.1.15 Confidence Level: 1 AUTHORS: NOTES:The E. coli enzyme contains a pyruvoyl group.
reactant: MODEL1310110061#
product: MODEL1310110061#

http://identifiers.org/biomodels.db/MODEL1310110061#_1fb3f2bd_b8ba_4ebc_83f9_cc90b7cae4c3
constant: false
is encoded by: hsa:6584
has only substance units: false
initial amount: NaN
type: Species
is: SBO:0000252
initial concentration: NaN
name: SLC22A5
is: O76082
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110061#_618e18f7_afb8_4da3_acc2_0a8a0f16d335
is: P22413
type: Species
initial concentration: NaN
constant: false
has only substance units: false
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:5167
boundary condition: true
name: ENPP1

metaR r1657
modifier: MODEL1310110061#
reactant: MODEL1310110061#
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is described by: ECO:0000000
type: Reaction
kinetic law: MODEL1310110061#
fast: false
reversible: true
is: SBO:0000185
product: MODEL1310110061#

metaM tststerone r
name: testosterone
constant: false
is: CHEBI:17347
is: SBO:0000247
initial amount: NaN
is: HMDB00234
notes: FORMULA: C19H28O2 CHARGE: 0 INCHI: InChI=1S/C19H28O2/c1-18-9-7-13(20)11-12(18)3-4-14-15-5-6-17(21)19(15,2)10-8-16(14)18/h11,14-17,21H,3-10H2,1-2H3/t14-,15-,16-,17-,18-,19-/m0/s1 EHMN_ABBREVIATION: C00535
has only substance units: false
type: Species
boundary condition: false
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110061#_0e65ac5e_e375_4b97_a77c_cd16293f2d6a
initial concentration: NaN
boundary condition: true
is encoded by: hsa:3032
is: P55084
constant: false
has only substance units: false
type: Species
is: SBO:0000252
initial amount: NaN
name: HADHB

metaR EX tyr L LPAREN e RPAREN
kinetic law: MODEL1310110061#
reactant: MODEL1310110061#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: L-Tyrosine exchange
type: Reaction

metaR SPHMYLNtg
name: sphingomyelin intracellular transport
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 1 AUTHORS: PMID:15907394 NOTES:unknown mechanism for transport - however must get to other intracellular compartments (e.g. lysosome for degradation) NJ
product: MODEL1310110061#
is described by: ECO:0000000
fast: false
kinetic law: MODEL1310110061#
type: Reaction
is: SBO:0000185
reversible: true
reactant: MODEL1310110061#

metaM h2o c
initial concentration: 1.0
is: SBO:0000247
notes: FORMULA: H2O CHARGE: 0
constant: false
name: H2O
is: HMDB02111
type: Species
is: CHEBI:3303
boundary condition: false
has only substance units: false
is: C00001
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110061#_4a41d566_f08b_4646_a385_c998701caca2
initial concentration: NaN
name: PRODH2
constant: false
boundary condition: true
initial amount: NaN
is: SBO:0000252
is encoded by: hsa:58510
is: Q9UF12
has only substance units: false
type: Species

metaR EX crvnc LPAREN e RPAREN
kinetic law: MODEL1310110061#
reactant: MODEL1310110061#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: nC22:6 exchange
type: Reaction

metaM mercplaccys e
has only substance units: false
notes: FORMULA: C6H10O5S2N CHARGE: -1 INCHI: InChI=1/C6H11NO5S2/c7-3(5(9)10)1-13-14-2-4(8)6(11)12/h3-4,8H,1-2,7H2,(H,9,10)(H,11,12)/t3-,4?/m0/s1
initial amount: NaN
is: SBO:0000247
constant: false
is: HMDB06512
name: 3-mercaptolactate-cysteine disulfide
boundary condition: false
initial concentration: 1.0
type: Species

http://identifiers.org/biomodels.db/MODEL1310110061#_c2aae5f5_8165_4f0e_b442_6d32c91992c6
name: SLC15A2
constant: false
is encoded by: hsa:6565
has only substance units: false
initial concentration: NaN
initial amount: NaN
is: SBO:0000252
is: Q16348
type: Species
boundary condition: true

metaM homoval m
notes: FORMULA: C9H9O4 CHARGE: -1 INCHI: InChI=1S/C9H10O4/c1-13-8-4-6(5-9(11)12)2-3-7(8)10/h2-4,10H,5H2,1H3,(H,11,12) HEPATONET_1.0_ABBREVIATION: HC01519 EHMN_ABBREVIATION: C05582
initial amount: NaN
is: CHEBI:545959
is: HMDB00118
type: Species
constant: false
is: SBO:0000247
initial concentration: 1.0
has only substance units: false
name: Homovanillate
boundary condition: false

metaR EX malthx LPAREN e RPAREN
kinetic law: MODEL1310110061#
reactant: MODEL1310110061#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Maltohexaose exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110061#_696b7105_325e_45cb_b3dc_539c87f430dd
is encoded by: hsa:3712
initial amount: NaN
type: Species
initial concentration: NaN
boundary condition: true
has only substance units: false
constant: false
name: IVD
is: B3KVI7
is: SBO:0000252

metaR FAOXC164m
kinetic law: MODEL1310110061#
product: MODEL1310110061#
reactant: MODEL1310110061#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: isomerization(C16:4)m
type: Reaction

metaR EX hco3 LPAREN e RPAREN
kinetic law: MODEL1310110061#
reactant: MODEL1310110061#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Bicarbonate exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110061#_b9e65a7e_822d_4df2_8841_db2c76f69579
has only substance units: false
name: _100287639_1_c
is: SBO:0000252
constant: false
type: Species
initial concentration: NaN
is encoded by: hsa:100287639
boundary condition: true
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110061#_eb23cc7c_55ab_4cdd_bbbf_7d9f9d5bf1be
is encoded by: hsa:23428
has only substance units: false
initial concentration: NaN
is: Q9UHI5
initial amount: NaN
constant: false
boundary condition: true
name: SLC7A8
is: SBO:0000252
type: Species

metaM creat e
is: HMDB00064
notes: FORMULA: C4H9N3O2 CHARGE: 0 INCHI: InChI=1S/C4H9N3O2/c1-7(4(5)6)2-3(8)9/h2H2,1H3,(H3,5,6)(H,8,9) HEPATONET_1.0_ABBREVIATION: HC00260 EHMN_ABBREVIATION: C00300
type: Species
is: SBO:0000247
has only substance units: false
is: CHEBI:16919
initial amount: NaN
constant: false
initial concentration: 1.0
name: creatine
boundary condition: false

metaR PAIL4P HStn
product: MODEL1310110061#
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 1 AUTHORS: NOTES:
kinetic law: MODEL1310110061#
type: Reaction
is: SBO:0000185
fast: false
name: phosphatidylinositol 4-phosphate nuclear transport (diffusion)
is described by: ECO:0000000
reactant: MODEL1310110061#

metaR TMNDNCt
kinetic law: MODEL1310110061#
reactant: MODEL1310110061#
is: SBO:0000185
name: fatty acid transport via diffusion
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11788354,PMID:12864740 NOTES:NJ
fast: false
is described by: ECO:0000000
reversible: true
product: MODEL1310110061#

metaR TAGt
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:
fast: false
name: triacylglycerol transport
type: Reaction
reversible: true
product: MODEL1310110061#
is described by: ECO:0000000
kinetic law: MODEL1310110061#
reactant: MODEL1310110061#

metaM CE2053 r
has only substance units: false
is: HMDB01509
initial concentration: 1.0
initial amount: NaN
is: CHEBI:57460
type: Species
boundary condition: false
notes: FORMULA: C20H29O5 CHARGE: -1 INCHI: InChI=1/C20H30O5/c21-17-10-6-2-1-3-7-12-18(22)13-8-4-5-9-14-19(23)15-11-16-20(24)25/h3-5,7-9,13-14,17-19,22-23H,1-2,6,10-12,15-16H2,(H,24,25)/p-1/b5-4+,7-3-,13-8+,14-9-/t18-,19-/m1/s1 EHMN_ABBREVIATION: CE2053
is: SBO:0000247
constant: false
name: 20-oxo-leukotriene B4

http://identifiers.org/biomodels.db/MODEL1310110061#_61db7c5c_7d9d_45fc_adf9_4e652fa282ef
type: Species
has only substance units: false
is: SBO:0000252
is: Q9NY65
name: EHHADH
initial amount: NaN
constant: false
boundary condition: true
initial concentration: NaN
is encoded by: hsa:1962

http://identifiers.org/biomodels.db/MODEL1310110061#_487b7b4d_d9bb_4837_9cc2_e625b8bd9a3e
initial amount: NaN
boundary condition: true
is: Q8WUD6
has only substance units: false
type: Species
name: CHPT1
constant: false
is: SBO:0000252
is encoded by: hsa:56994
initial concentration: NaN

metaR r1658
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reversible: true
reactant: MODEL1310110061#
is described by: ECO:0000000
type: Reaction
product: MODEL1310110061#
fast: false
is: SBO:0000185
kinetic law: MODEL1310110061#
modifier: MODEL1310110061#

metaM dece4coa m
notes: FORMULA: C31H48N7O17P3S CHARGE: -4
initial amount: NaN
constant: false
name: 4-decenoylcoa
is: HMDB02145
boundary condition: false
is: SBO:0000247
has only substance units: false
initial concentration: 1.0
type: Species

http://identifiers.org/biomodels.db/MODEL1310110061#_380f0061_283d_493e_a306_27a10d948cf5
is: Q9HBU6
is: SBO:0000252
has only substance units: false
is encoded by: hsa:55500
type: Species
name: ETNK1
initial amount: NaN
initial concentration: NaN
boundary condition: true
constant: false

metaM ipdp c
is: SBO:0000247
has only substance units: false
notes: FORMULA: C5H9O7P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00127 EHMN_ABBREVIATION: C00129
initial concentration: 1.0
is: HMDB01347
is: C00129
initial amount: NaN
boundary condition: false
type: Species
is: CHEBI:128769
constant: false
name: Isopentenyl diphosphate

metaM fadh2 r
boundary condition: false
type: Species
name: FADH2(2-)
is: HMDB01197
initial amount: NaN
is: CHEBI:58307
is: SBO:0000247
constant: false
initial concentration: 1.0
has only substance units: false
notes: FORMULA: C27H33N9O15P2 CHARGE: -2 INCHI: InChI=1S/C27H35N9O15P2/c1-10-3-12-13(4-11(10)2)35(24-18(32-12)25(42)34-27(43)33-24)5-14(37)19(39)15(38)6-48-52(44,45)51-53(46,47)49-7-16-20(40)21(41)26(50-16)36-9-31-17-22(28)29-8-30-23(17)36/h3-4,8-9,14-16,19-21,26,32,37-41H,5-7H2,1-2H3,(H,44,45)(H,46,47)(H2,28,29,30)(H2,33,34,42,43)/p-2/t14-,15+,16+,19-,20+,21+,26+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00770 EHMN_ABBREVIATION: C01352

metaR PAIL HStn
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 1 AUTHORS: NOTES:
kinetic law: MODEL1310110061#
type: Reaction
name: phosphatidylinositol nuclear transport (diffusion)
is described by: ECO:0000000
is: SBO:0000185
product: MODEL1310110061#
reversible: true
reactant: MODEL1310110061#
fast: false

http://identifiers.org/biomodels.db/MODEL1310110061#_7998e482_0430_496b_be0b_1c44e0aa5c1c
boundary condition: true
is: SBO:0000252
type: Species
is: P04062
initial amount: NaN
name: GBA
is encoded by: hsa:2629
has only substance units: false
constant: false
initial concentration: NaN

metaM coa r
constant: false
is: C00010
is: HMDB01423
is: SBO:0000247
notes: FORMULA: C21H32N7O16P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00020 EHMN_ABBREVIATION: C00010
has only substance units: false
name: Coenzyme A
initial amount: NaN
boundary condition: false
type: Species
initial concentration: 1.0
is: CHEBI:57287

metaM HC00822 e
is: CHEBI:28681
initial concentration: 1.0
notes: FORMULA: C16H28N2O11 CHARGE: 0 INCHI: InChI=1S/C16H28N2O11/c1-5(21)17-9-13(25)14(8(4-20)27-15(9)26)29-16-10(18-6(2)22)12(24)11(23)7(3-19)28-16/h7-16,19-20,23-26H,3-4H2,1-2H3,(H,17,21)(H,18,22)/t7-,8-,9-,10-,11-,12-,13-,14-,15?,16+/m1/s1 EHMN_ABBREVIATION: C01674
name: Chitobiose
constant: false
is: SBO:0000247
type: Species
initial amount: NaN
has only substance units: false
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110061#_cd2e5e3c_bdb5_4d18_8ba6_cf93fdd627f6
initial concentration: NaN
boundary condition: true
has only substance units: false
type: Species
is: Q15735
is: SBO:0000252
is encoded by: hsa:27124
constant: false
initial amount: NaN
name: INPP5J

metaM acgam1p c
has only substance units: false
initial concentration: 1.0
boundary condition: false
is: HMDB01367
name: N-Acetyl-D-glucosamine 1-phosphate
is: CHEBI:7125
constant: false
notes: FORMULA: C8H14NO9P CHARGE: -2 INCHI: InChI=1S/C8H16NO9P/c1-3(11)9-5-7(13)6(12)4(2-10)17-8(5)18-19(14,15)16/h4-8,10,12-13H,2H2,1H3,(H,9,11)(H2,14,15,16)/t4-,5-,6-,7-,8?/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01256 EHMN_ABBREVIATION: C04256
initial amount: NaN
type: Species
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110061#_e3277a5f_dfbb_4d0f_b3b6_6b662589677a
type: Species
constant: false
initial amount: NaN
is: E7EPA7
has only substance units: false
is: SBO:0000252
name: TKT
boundary condition: true
is encoded by: hsa:7086
initial concentration: NaN

metaM h2o e
is: SBO:0000247
constant: false
is: HMDB02111
initial concentration: 1.0
name: H2O
type: Species
is: CHEBI:15377
boundary condition: false
is: C00001
notes: FORMULA: H2O CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00011 EHMN_ABBREVIATION: C00001
initial amount: NaN
has only substance units: false

metaM 3aib D m
is: HMDB02299
initial concentration: 1.0
is: C03265
is: SBO:0000247
initial amount: NaN
has only substance units: false
type: Species
boundary condition: false
name: D-3-Amino-isobutanoate
notes: FORMULA: C4H9NO2 CHARGE: 0 INCHI: InChI=1/C4H9NO2/c1-3(2-5)4(6)7/h3H,2,5H2,1H3,(H,6,7)/t3-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00715
constant: false

metaR URIt4
fast: false
product: MODEL1310110061#
kinetic law: MODEL1310110061#
reactant: MODEL1310110061#
reversible: false
type: Reaction
name: uridine transport in via sodium symport
notes: GENE_ASSOCIATION: (9154.2) or (9154.1) or (64078.1) or (9153.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12856181 NOTES:SAB
modifier: MODEL1310110061#
is described by: ECO:0000269
is: SBO:0000185

metaR r1659
is described by: ECO:0000000
type: Reaction
modifier: MODEL1310110061#
reactant: MODEL1310110061#
product: MODEL1310110061#
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
kinetic law: MODEL1310110061#
is: SBO:0000185
fast: false
reversible: true

metaR PGCD
modifier: MODEL1310110061#
is: SBO:0000176
product: MODEL1310110061#
name: phosphoglycerate dehydrogenase
type: Reaction
kinetic law: MODEL1310110061#
notes: GENE_ASSOCIATION: (26227.1) SUBSYSTEM: Glycine, serine, alanine and threonine metabolism EC Number: 1.1.1.95 Confidence Level: 4 AUTHORS: PMID:10713460 NOTES:
reversible: false
reactant: MODEL1310110061#
fast: false
is version of: http://identifiers.org/ec-code/1.1.1.95
is described by: ECO:0000269

metaR EX hxan LPAREN e RPAREN
kinetic law: MODEL1310110061#
reactant: MODEL1310110061#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Hypoxanthine exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110061#_1821b0a3_0326_42f7_af1a_ec99ee2e5e1a
constant: false
is: SBO:0000252
is encoded by: hsa:9963
initial concentration: NaN
name: SLC23A1
has only substance units: false
boundary condition: true
type: Species
initial amount: NaN

metaR TYRCBOX
notes: GENE_ASSOCIATION: (1644.1) SUBSYSTEM: Tyrosine metabolism EC Number: 4.1.1.28 Confidence Level: 4 AUTHORS: PMID:6131938 NOTES:SAB KEGG also says EC 4.1.1.28
is described by: ECO:0000134
is: SBO:0000176
is version of: http://identifiers.org/ec-code/4.1.1.28
fast: false
modifier: MODEL1310110061#
reversible: false
type: Reaction
name: L-Tyrosine carboxy-lyase
reactant: MODEL1310110061#
product: MODEL1310110061#
kinetic law: MODEL1310110061#

metaM ethamp r
has only substance units: false
type: Species
constant: false
is: CHEBI:58190
name: O-phosphonatoethanaminium(1-)
is: SBO:0000247
initial amount: NaN
is: HMDB00224
notes: FORMULA: C2H7NO4P CHARGE: -1 INCHI: InChI=1S/C2H8NO4P/c3-1-2-7-8(4,5)6/h1-3H2,(H2,4,5,6)/p-1 HEPATONET_1.0_ABBREVIATION: HC00293 EHMN_ABBREVIATION: C00346
initial concentration: 1.0
boundary condition: false

metaR PSSA2 hs
notes: GENE_ASSOCIATION: (81490.1) SUBSYSTEM: Glycerophospholipid metabolism EC Number: 2.7.8.8 Confidence Level: 4 AUTHORS: NOTES:phosphatidylethanolamine version as substrate NJ
modifier: MODEL1310110061#
reversible: true
is: SBO:0000176
product: MODEL1310110061#
kinetic law: MODEL1310110061#
name: Phosphatidylserine synthase homo sapiens
fast: false
reactant: MODEL1310110061#
is version of: http://identifiers.org/ec-code/2.7.8.29
is described by: ECO:0000269
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110061#_71761fb0_946f_4d51_8838_45b18d939e4a
is: SBO:0000252
type: Species
is encoded by: hsa:8394
has only substance units: false
boundary condition: true
initial concentration: NaN
name: PIP5K1A
constant: false
initial amount: NaN
is: Q99755

metaR SERASNNaEx
type: Reaction
fast: false
is: SBO:0000185
product: MODEL1310110061#
reactant: MODEL1310110061#
name: L-serine/L-asparagine Na-dependent exchange (Ser-L in)
is described by: ECO:0000269
modifier: MODEL1310110061#
notes: GENE_ASSOCIATION: (6510.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14530974 NOTES:SAB see Kanai and Hediger 2004 (2003), PMID 14530974
reversible: false
kinetic law: MODEL1310110061#

metaM cholate c
type: Species
is: HMDB00619
constant: false
initial concentration: 1.0
initial amount: NaN
name: Cholate
is: CHEBI:29747
notes: FORMULA: C24H39O5 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00502 EHMN_ABBREVIATION: C00695
is: SBO:0000247
has only substance units: false
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110061#_2de5375f_08aa_4958_bf42_c724ad3cf0c1
name: GNPDA1
constant: false
is encoded by: hsa:10007
has only substance units: false
is: SBO:0000252
boundary condition: true
is: P46926
type: Species
initial amount: NaN
initial concentration: NaN

metaM 4hbz m
initial concentration: 1.0
constant: false
boundary condition: false
is: HMDB00500
is: SBO:0000247
is: CHEBI:17879
name: 4-hydroxybenzoate
has only substance units: false
notes: FORMULA: C7H5O3 CHARGE: -1 INCHI: InChI=1S/C7H6O3/c8-6-3-1-5(2-4-6)7(9)10/h1-4,8H,(H,9,10)/p-1
initial amount: NaN
type: Species

metaR NOt
kinetic law: MODEL1310110061#
reversible: true
product: MODEL1310110061#
name: NO transport (diffusion)
fast: false
is described by: ECO:0000000
type: Reaction
is: SBO:0000185
reactant: MODEL1310110061#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 1 AUTHORS: NOTES:IT (06-16-04)

metaR ADRNt
product: MODEL1310110061#
type: Reaction
reactant: MODEL1310110061#
kinetic law: MODEL1310110061#
reversible: true
name: fatty acid transport via diffusion
is described by: ECO:0000000
is: SBO:0000185
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11788354,PMID:12864740 NOTES:NJ

http://identifiers.org/biomodels.db/MODEL1310110061#_9f75d11e_5d18_4e03_ab96_5b59f8aaaac3
is encoded by: hsa:2819
is: F8W1L5
boundary condition: true
type: Species
has only substance units: false
name: GPD1
constant: false
initial amount: NaN
initial concentration: NaN
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110061#_6c183654_6ea4_4c5e_98a8_7f20b39560b4
initial concentration: NaN
initial amount: NaN
boundary condition: true
name: SLC26A6
is: Q9Y3Y1
constant: false
is: SBO:0000252
is encoded by: hsa:65010
type: Species
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110061#_a3f9c845_761a_435d_8fe7_28bf4f865f90
is encoded by: hsa:AI640625
type: Species
initial concentration: NaN
initial amount: NaN
has only substance units: false
name: _AI640625_1_c
is: SBO:0000252
constant: false
boundary condition: true

metaM icit c
has only substance units: false
type: Species
is: HMDB00193
is: C00311
initial concentration: 1.0
initial amount: NaN
is: CHEBI:16087
constant: false
boundary condition: false
name: Isocitrate
notes: FORMULA: C6H5O7 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00266 EHMN_ABBREVIATION: C00311
is: SBO:0000247

metaM malcoa r
type: Species
name: malonyl-CoA(4-)
notes: FORMULA: C24H33N7O19P3S CHARGE: -5 INCHI: InChI=1S/C24H38N7O19P3S/c1-24(2,19(37)22(38)27-4-3-13(32)26-5-6-54-15(35)7-14(33)34)9-47-53(44,45)50-52(42,43)46-8-12-18(49-51(39,40)41)17(36)23(48-12)31-11-30-16-20(25)28-10-29-21(16)31/h10-12,17-19,23,36-37H,3-9H2,1-2H3,(H,26,32)(H,27,38)(H,33,34)(H,42,43)(H,44,45)(H2,25,28,29)(H2,39,40,41)/p-5/t12-,17-,18-,19+,23-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00086 EHMN_ABBREVIATION: C00083
constant: false
is: CHEBI:57384
has only substance units: false
is: HMDB01175
boundary condition: false
is: SBO:0000247
initial amount: NaN
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110061#_8363f1e9_9722_4a2e_afa7_c43ba6f848f0
is: P35354
type: Species
initial concentration: NaN
initial amount: NaN
is: SBO:0000252
has only substance units: false
boundary condition: true
is encoded by: hsa:5743
name: PTGS2
constant: false

metaM 5dhf e
notes: FORMULA: C39H43N11O18 CHARGE: -6 INCHI: InChI=1/C39H47N11O18/c40-39-49-31-30(33(58)50-39)43-19(16-42-31)15-41-18-3-1-17(2-4-18)32(57)48-24(38(67)68)8-13-28(54)46-22(36(63)64)6-11-26(52)44-20(34(59)60)5-10-25(51)45-21(35(61)62)7-12-27(53)47-23(37(65)66)9-14-29(55)56/h1-4,16,20-24,41H,5-15H2,(H,44,52)(H,45,51)(H,46,54)(H,47,53)(H,48,57)(H,55,56)(H,59,60)(H,61,62)(H,63,64)(H,65,66)(H,67,68)(H3,40,42,49,50,58)/t20-,21-,22-,23-,24-/m0/s1
is: SBO:0000247
name: pentaglutamyl folate (DHF)
initial amount: NaN
has only substance units: false
initial concentration: 1.0
constant: false
type: Species
boundary condition: false
is: HMDB06487

http://identifiers.org/biomodels.db/MODEL1310110061#_885c0978_7e9f_470b_8716_0f38569b60e6
initial amount: NaN
is: SBO:0000252
type: Species
boundary condition: true
has only substance units: false
initial concentration: NaN
name: RHBG
is encoded by: hsa:57127
constant: false
is: Q9H310

http://identifiers.org/biomodels.db/MODEL1310110061#_4cd5849e_280c_4c94_95d2_97e45f9c2b65
is encoded by: hsa:AA278423
boundary condition: true
name: _AA278423_1_m
initial concentration: NaN
type: Species
is: SBO:0000252
initial amount: NaN
constant: false
has only substance units: false

metaR AKR1C41
kinetic law: MODEL1310110061#
is described by: ECO:0000269
reversible: false
modifier: MODEL1310110061#
notes: GENE_ASSOCIATION: (1109.1) SUBSYSTEM: Bile acid synthesis EC Number: 1.1.1.50 Confidence Level: 4 AUTHORS: NOTES:NJ
is version of: http://identifiers.org/ec-code/1.1.1.225
is: SBO:0000176
fast: false
type: Reaction
name: aldo-keto reductase family 1, member C4 (chlordecone reductase; 3-alpha hydroxysteroid dehydrogenase, type I; dihydrodiol dehydrogenase 4)
product: MODEL1310110061#
reactant: MODEL1310110061#

metaM g3p c
notes: FORMULA: C3H5O6P CHARGE: -2 INCHI: " HEPATONET_1.0_ABBREVIATION: HC00116
boundary condition: false
name: Glyceraldehyde 3-phosphate
is: SBO:0000247
initial amount: NaN
is: http://identifiers.org/pubchem.compound/3930
has only substance units: false
is: CHEBI:58027
initial concentration: 1.0
is: HMDB01112
type: Species
is: C00661
constant: false

metaM retinal cis 13 r
has only substance units: false
is: SBO:0000247
is: HMDB06220
notes: FORMULA: C20H28O CHARGE: 0 INCHI: InChI=1S/C20H28O/c1-16(8-6-9-17(2)13-15-21)11-12-19-18(3)10-7-14-20(19,4)5/h6,8-9,11-13,15H,7,10,14H2,1-5H3/b9-6+,12-11+,16-8+,17-13- EHMN_ABBREVIATION: CE5589
boundary condition: false
is: CHEBI:45487
name: 13-cis-retinal
initial amount: NaN
initial concentration: 1.0
type: Species
constant: false

http://identifiers.org/biomodels.db/MODEL1310110061#_1169f7cc_4c90_4b1d_a6e8_3fce0c2e1e8f
is encoded by: hsa:2878
name: GPX3
initial amount: NaN
is: P22352
initial concentration: NaN
constant: false
is: SBO:0000252
type: Species
boundary condition: true
has only substance units: false

metaR r1548
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
kinetic law: MODEL1310110061#
reversible: true
is: SBO:0000185
reactant: MODEL1310110061#
is described by: ECO:0000000
fast: false
product: MODEL1310110061#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110061#_6b87b50a_f00e_4511_85f1_86a8e108d77b
initial amount: NaN
is encoded by: hsa:10723
has only substance units: false
initial concentration: NaN
constant: false
is: SBO:0000252
name: SLC12A7
boundary condition: true
type: Species
is: Q9Y666

metaR r1888
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
type: Reaction
kinetic law: MODEL1310110061#
name: Y+LAT2 Utilized transport
product: MODEL1310110061#
reactant: MODEL1310110061#
is: SBO:0000185
reversible: false
modifier: MODEL1310110061#
fast: false
is described by: ECO:0000000

metaR GLNtN1
is: SBO:0000185
is described by: ECO:0000269
reversible: true
type: Reaction
kinetic law: MODEL1310110061#
reactant: MODEL1310110061#
product: MODEL1310110061#
fast: false
modifier: MODEL1310110061#
notes: GENE_ASSOCIATION: (92745.1) or (10991.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10823827,PMID:12845534 NOTES:SAB based om PMID 10823827
name: Glutamine transport (Na, H coupled)

metaM gln L c
is: HMDB00641
initial concentration: 1.0
boundary condition: false
initial amount: NaN
is: CHEBI:18050
type: Species
has only substance units: false
is: SBO:0000247
notes: FORMULA: C5H10N2O3 CHARGE: 0 INCHI: InChI=1S/C5H10N2O3/c6-3(5(9)10)1-2-4(7)8/h3H,1-2,6H2,(H2,7,8)(H,9,10)/t3-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00067
constant: false
name: L-glutamine

http://identifiers.org/biomodels.db/MODEL1310110061#_5a2764ce_c072_4a26_9d36_1c52dbb1e9a8
boundary condition: true
name: PLCB4
is: Q15147
initial concentration: NaN
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:5332
type: Species
has only substance units: false
constant: false

metaM h2o g
is: SBO:0000247
boundary condition: false
type: Species
has only substance units: false
initial concentration: 1.0
name: water
is: CHEBI:15377
is: HMDB02111
notes: FORMULA: H2O CHARGE: 0 INCHI: InChI=1S/H2O/h1H2 HEPATONET_1.0_ABBREVIATION: HC00011 EHMN_ABBREVIATION: C00001
initial amount: NaN
constant: false

http://identifiers.org/biomodels.db/MODEL1310110061#_627b5313_32ed_46d4_97e3_ebaee97bb07f
is: SBO:0000252
initial concentration: NaN
is encoded by: hsa:3294
boundary condition: true
type: Species
name: HSD17B2
is: P37059
constant: false
initial amount: NaN
has only substance units: false

metaM ksii core2 e
initial amount: NaN
initial concentration: 1.0
name: keratan sulfate II (core 2-linked)
constant: false
is: CHEBI:17268
has only substance units: false
is: HMDB00211
is: SBO:0000247
notes: FORMULA: C81H129N6O67S3X CHARGE: -4
type: Species
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110061#_8404197c_e6ac_4cff_bee9_edbd6cc7ff8e
is: P00558
constant: false
initial concentration: NaN
has only substance units: false
name: PGK1
is encoded by: hsa:5230
is: SBO:0000252
initial amount: NaN
boundary condition: true
type: Species

metaR EX atp LPAREN e RPAREN
kinetic law: MODEL1310110061#
reactant: MODEL1310110061#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: ATP exchange
type: Reaction

metaR AMETt2m
is: SBO:0000185
name: S-Adenosyl-L-methionine reversible transport, mitochondrial
fast: false
reversible: true
modifier: MODEL1310110061#
notes: GENE_ASSOCIATION: (115286.3) or (115286.2) or (115286.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14674884 NOTES:Added by RS/TV (6/17/05)
type: Reaction
kinetic law: MODEL1310110061#
reactant: MODEL1310110061#
is described by: ECO:0000269
product: MODEL1310110061#

metaM ksii core2 deg3 l
boundary condition: false
has only substance units: false
initial amount: NaN
type: Species
notes: FORMULA: C58H94N5O46S2X CHARGE: -2
initial concentration: 1.0
constant: false
is: CHEBI:12936
name: keratan sulfate II (core 2-linked), degradation product 3
is: SBO:0000247
is: HMDB00143

metaR 4ABUTtcn
is: SBO:0000185
is described by: ECO:0000134
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 1 AUTHORS: Jane D. Carver, W. Allan Walkera , The Journal of Nutritional Biochemistry, Volume 6, Issue 2, February 1995, Pages 58?72. NOTES:added during gap-filling, required for GABA role in cell proliferation.
product: MODEL1310110061#
fast: false
reversible: false
reactant: MODEL1310110061#
type: Reaction
name: transport of GABA
kinetic law: MODEL1310110061#

metaM dec47dicoa m
boundary condition: false
initial amount: NaN
notes: FORMULA: C31H46N7O17P3S CHARGE: -4
initial concentration: 1.0
type: Species
is: http://identifiers.org/pubchem.compound/16019966
constant: false
has only substance units: false
is: SBO:0000247
name: 4,7-decadienoylcoa

metaM cholcoads x
name: 3alpha,7alpha,12alpha-Trihydroxy-5beta-cholest-24-enoyl-CoA
constant: false
initial concentration: 1.0
is: SBO:0000247
is: CHEBI:27505
initial amount: NaN
type: Species
is: HMDB06889
boundary condition: false
has only substance units: false
notes: FORMULA: C48H74N7O20P3S CHARGE: -4 INCHI: InChI=1S/C48H78N7O20P3S/c1-25(29-10-11-30-36-31(20-34(58)48(29,30)6)47(5)14-12-28(56)18-27(47)19-32(36)57)8-7-9-26(2)45(63)79-17-16-50-35(59)13-15-51-43(62)40(61)46(3,4)22-72-78(69,70)75-77(67,68)71-21-33-39(74-76(64,65)66)38(60)44(73-33)55-24-54-37-41(49)52-23-53-42(37)55/h9,23-25,27-34,36,38-40,44,56-58,60-61H,7-8,10-22H2,1-6H3,(H,50,59)(H,51,62)(H,67,68)(H,69,70)(H2,49,52,53)(H2,64,65,66)/t25-,27+,28-,29-,30+,31+,32-,33-,34+,36+,38-,39-,40+,44-,47+,48-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01466 EHMN_ABBREVIATION: C05460

http://identifiers.org/biomodels.db/MODEL1310110061#_a0bf5290_aa6c_4dae_9498_080e97f23b00
is: C9JFZ1
initial concentration: NaN
constant: false
boundary condition: true
initial amount: NaN
name: SYNJ1
is: SBO:0000252
type: Species
has only substance units: false
is encoded by: hsa:8867

http://identifiers.org/biomodels.db/MODEL1310110061#_964ee5e1_fdba_4698_b011_d5d78b477de5
has only substance units: false
is encoded by: hsa:6536
name: SLC6A9
is: SBO:0000252
constant: false
boundary condition: true
type: Species
initial concentration: NaN
initial amount: NaN
is: B7Z3W8

metaR r0650
is version of: http://identifiers.org/ec-code/4.1.1.36
is described by: ECO:0000000
reactant: MODEL1310110061#
product: MODEL1310110061#
name: Chenodeoxycholate:CoA ligase (AMP-forming) Bile acid biosynthesis EC:6.2.1.7
fast: false
type: Reaction
is: SBO:0000176
notes: GENE_ASSOCIATION: (60490.1) SUBSYSTEM: Bile acid synthesis EC Number: 6.2.1.7 Confidence Level: 0 AUTHORS: PMID:10749848,PMID:10884298,PMID:15026425,PMID:438652,PMID:6173037 NOTES:
kinetic law: MODEL1310110061#
modifier: MODEL1310110061#
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110061#_9fe441a1_74e7_4c5e_86df_338452c52022
constant: false
has only substance units: false
type: Species
is encoded by: hsa:5297
boundary condition: true
is: SBO:0000252
name: PI4KA
is: B4DYG5
initial concentration: NaN
initial amount: NaN

metaR r1549
reactant: MODEL1310110061#
is described by: ECO:0000000
product: MODEL1310110061#
type: Reaction
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
fast: false
kinetic law: MODEL1310110061#
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110061#_82eedc47_ffc7_4096_bf21_9fa6ab6e6ea7
has only substance units: false
initial amount: NaN
type: Species
name: _2544_1_c
is: SBO:0000252
is encoded by: hsa:2544
initial concentration: NaN
constant: false
boundary condition: true

metaR EX arachd LPAREN e RPAREN
kinetic law: MODEL1310110061#
reactant: MODEL1310110061#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: nC20:4 exchange
type: Reaction

metaM mal L e
is: HMDB00156
is: CHEBI:15589
boundary condition: false
constant: false
is: SBO:0000247
initial concentration: 1.0
type: Species
has only substance units: false
name: (S)-malate(2-)
initial amount: NaN
notes: FORMULA: C4H4O5 CHARGE: -2 INCHI: InChI=1S/C4H6O5/c5-2(4(8)9)1-3(6)7/h2,5H,1H2,(H,6,7)(H,8,9)/p-2/t2-/m0/s1

metaM xol7ah3 c
initial concentration: 1.0
notes: FORMULA: C27H48O3 CHARGE: 0 INCHI: InChI=1S/C27H48O3/c1-17(16-28)6-5-7-18(2)21-8-9-22-25-23(11-13-27(21,22)4)26(3)12-10-20(29)14-19(26)15-24(25)30/h17-25,28-30H,5-16H2,1-4H3/t17?,18-,19+,20-,21-,22+,23+,24-,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01453 EHMN_ABBREVIATION: C05444
constant: false
type: Species
has only substance units: false
name: 5beta-cholestane-3alpha,7alpha,26-triol
boundary condition: false
is: HMDB12455
is: CHEBI:28540
initial amount: NaN
is: SBO:0000247

metaR UDPGD
is: SBO:0000176
modifier: MODEL1310110061#
is described by: ECO:0000304
reactant: MODEL1310110061#
is version of: http://identifiers.org/ec-code/1.1.1.22
type: Reaction
name: UDPglucose 6-dehydrogenase
reversible: false
fast: false
product: MODEL1310110061#
kinetic law: MODEL1310110061#
notes: GENE_ASSOCIATION: (7358.1) SUBSYSTEM: Starch and sucrose metabolism EC Number: 1.1.1.22 Confidence Level: 2 AUTHORS: PMID:9296457,PMID:9737970 NOTES:JLR

metaM coa e
is: HMDB01423
is: CHEBI:57287
constant: false
name: Coenzyme A
boundary condition: false
initial amount: NaN
type: Species
is: SBO:0000247
notes: FORMULA: C21H32N7O16P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00020 EHMN_ABBREVIATION: C00010
initial concentration: 1.0
is: C00010
has only substance units: false

metaM datp c
is: CHEBI:61404
is: SBO:0000247
initial concentration: 1.0
boundary condition: false
name: dATP
notes: FORMULA: C10H12N5O12P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00129 EHMN_ABBREVIATION: C00131
has only substance units: false
initial amount: NaN
is: HMDB01532
is: C00131
constant: false
type: Species

metaR SERtN1
product: MODEL1310110061#
modifier: MODEL1310110061#
type: Reaction
reactant: MODEL1310110061#
is: SBO:0000185
is described by: ECO:0000269
kinetic law: MODEL1310110061#
notes: GENE_ASSOCIATION: (92745.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12845534 NOTES:SAB based on PMID 12845534
reversible: true
fast: false
name: Serine transport (Na, H coupled)

http://identifiers.org/biomodels.db/MODEL1310110061#_a98b37c3_cfad_4612_ae6a_069c567c6588
has only substance units: false
initial amount: NaN
is: SBO:0000252
boundary condition: true
type: Species
is encoded by: hsa:56301
is: Q9NS82
name: SLC7A10
initial concentration: NaN
constant: false

metaR r0651
kinetic law: MODEL1310110061#
modifier: MODEL1310110061#
is described by: ECO:0000000
product: MODEL1310110061#
reactant: MODEL1310110061#
notes: GENE_ASSOCIATION: (10637.1) or (5831.1) or (29920.1) or (65263.1) SUBSYSTEM: Bile acid synthesis EC Number: 6.2.1.7 Confidence Level: 0 AUTHORS: PMID:10749848,PMID:10884298,PMID:15026425,PMID:438652,PMID:6173037 NOTES:
fast: false
type: Reaction
is: SBO:0000176
name: Chenodeoxycholate:CoA ligase (AMP-forming) Bile acid biosynthesis EC:6.2.1.7
is version of: http://identifiers.org/ec-code/1.5.1.2
reversible: true

metaR NRPPHRt4 2 r
reversible: true
kinetic law: MODEL1310110061#
is described by: ECO:0000269
product: MODEL1310110061#
type: Reaction
modifier: MODEL1310110061#
is: SBO:0000185
fast: false
reactant: MODEL1310110061#
name: Norepinephrine reversible transport in via sodium symport (1:2)
notes: GENE_ASSOCIATION: (6530.1) or (6531.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12719981 NOTES:SAB

metaR ETHAK
kinetic law: MODEL1310110061#
reactant: MODEL1310110061#
type: Reaction
notes: GENE_ASSOCIATION: (1119.2) or (55500.1) or (1119.1) or (55224.1) SUBSYSTEM: Glycerophospholipid metabolism EC Number: 2.7.1.82 Confidence Level: 4 AUTHORS: NOTES:NCD
is: SBO:0000176
name: Ethanolamine kinase
fast: false
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/2.7.1.82
product: MODEL1310110061#
is version of: http://identifiers.org/ec-code/2.7.1.32
modifier: MODEL1310110061#
reversible: false

metaM gln L e
name: L-glutamine
initial amount: NaN
is: CHEBI:18050
initial concentration: 1.0
boundary condition: false
type: Species
is: SBO:0000247
constant: false
has only substance units: false
is: HMDB00641
notes: FORMULA: C5H10N2O3 CHARGE: 0 INCHI: InChI=1S/C5H10N2O3/c6-3(5(9)10)1-2-4(7)8/h3H,1-2,6H2,(H2,7,8)(H,9,10)/t3-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00067

metaM mercplaccys c
has only substance units: false
initial amount: NaN
constant: false
name: 3-mercaptolactate-cysteine disulfide
is: HMDB06512
notes: FORMULA: C6H10O5S2N CHARGE: -1 INCHI: InChI=1/C6H11NO5S2/c7-3(5(9)10)1-13-14-2-4(8)6(11)12/h3-4,8H,1-2,7H2,(H,9,10)(H,11,12)/t3-,4?/m0/s1
initial concentration: 1.0
type: Species
is: SBO:0000247
boundary condition: false

metaM 5aizc c
has only substance units: false
boundary condition: false
constant: false
is: CHEBI:58564
is: SBO:0000247
is: HMDB06273
name: 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate
type: Species
initial concentration: 1.0
is: C04751
notes: FORMULA: C9H11N3O9P CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC01347 EHMN_ABBREVIATION: C04751
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110061#_59fa57fa_6297_49ed_bae0_57a2d5503f82
is encoded by: hsa:56953
constant: false
is: Q9NPB1
has only substance units: false
is: SBO:0000252
initial concentration: NaN
type: Species
initial amount: NaN
name: NT5M
boundary condition: true

metaM so3 m
initial concentration: 1.0
is: CHEBI:17137
name: hydrogensulfite
initial amount: NaN
notes: FORMULA: O3S CHARGE: -2 INCHI: InChI=1S/H2O3S/c1-4(2)3/h(H2,1,2,3)/p-1 HEPATONET_1.0_ABBREVIATION: HC00096 EHMN_ABBREVIATION: C00094
is: HMDB00240
is: SBO:0000247
has only substance units: false
constant: false
type: Species
boundary condition: false

metaR RE2954C
reactant: MODEL1310110061#
kinetic law: MODEL1310110061#
is version of: http://identifiers.org/ec-code/2.7.1.40
fast: false
product: MODEL1310110061#
is: SBO:0000176
reversible: true
modifier: MODEL1310110061#
is described by: ECO:0000000
type: Reaction
notes: GENE_ASSOCIATION: (5315.1) SUBSYSTEM: Pyrimidine synthesis EC Number: 2.7.1.40 Confidence Level: 0 AUTHORS: PMID:10585400,PMID:8967971 NOTES:
name: RE2954

metaR r0497
reversible: true
is: SBO:0000176
kinetic law: MODEL1310110061#
type: Reaction
is version of: http://identifiers.org/ec-code/1.2.4.2
is described by: ECO:0000000
name: dTTP nucleotidohydrolase Pyrimidine metabolism EC:3.6.1.39
reactant: MODEL1310110061#
modifier: MODEL1310110061#
product: MODEL1310110061#
fast: false
notes: GENE_ASSOCIATION: (4967.1) or (55753.1) SUBSYSTEM: Pyrimidine catabolism EC Number: 3.6.1.39 Confidence Level: 0 AUTHORS: PMID:1320895,PMID:6097526,PMID:6297538 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110061#_1bc720f6_85e2_4ac9_bddd_19908301aa9d
type: Species
initial amount: NaN
name: PROSC
boundary condition: true
initial concentration: NaN
constant: false
is: SBO:0000252
is: O94903
has only substance units: false
is encoded by: hsa:11212

metaR TETTET6t
reactant: MODEL1310110061#
kinetic law: MODEL1310110061#
fast: false
name: fatty acid transport via diffusion
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11788354,PMID:12864740 NOTES:NJ
is: SBO:0000185
type: Reaction
product: MODEL1310110061#
reversible: true
is described by: ECO:0000000

metaR FAOXTC162TC142m
kinetic law: MODEL1310110061#
product: MODEL1310110061#
reactant: MODEL1310110061#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation trans(C16:2-->C14:2)m
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110061#_b8c4a61d_5ec6_4d7b_8591_658d914283bd
type: Species
is: P14060
initial concentration: NaN
has only substance units: false
is: SBO:0000252
constant: false
is encoded by: hsa:3283
initial amount: NaN
name: HSD3B1
boundary condition: true

metaR r1809
product: MODEL1310110061#
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is described by: ECO:0000000
name: Y+LAT2 Utilized transport
is: SBO:0000185
modifier: MODEL1310110061#
kinetic law: MODEL1310110061#
reactant: MODEL1310110061#
fast: false
reversible: false
type: Reaction

metaR DM fol
kinetic law: MODEL1310110061#
reactant: MODEL1310110061#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: Demand for folic aicd
type: Reaction

metaR EX fe2 LPAREN e RPAREN
kinetic law: MODEL1310110061#
reactant: MODEL1310110061#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: EX_fe2(u)
type: Reaction

metaR GALU
is version of: http://identifiers.org/ec-code/2.7.7.9
is: SBO:0000176
product: MODEL1310110061#
is described by: ECO:0000134
reactant: MODEL1310110061#
kinetic law: MODEL1310110061#
fast: false
notes: GENE_ASSOCIATION: (7360.1) or (7359.1) or (7360.2) SUBSYSTEM: Galactose metabolism EC Number: 2.7.7.9 Confidence Level: 0 AUTHORS: PMID:9119383 NOTES:Human Y/N: Y
type: Reaction
name: UTP-glucose-1-phosphate uridylyltransferase
reversible: true
modifier: MODEL1310110061#

metaM coa c
name: Coenzyme A
is: HMDB01423
is: CHEBI:3312
constant: false
notes: FORMULA: C21H32N7O16P3S CHARGE: -4
boundary condition: false
initial amount: NaN
initial concentration: 1.0
type: Species
has only substance units: false
is: SBO:0000247
is: C00010

http://identifiers.org/biomodels.db/MODEL1310110061#_2c3d4960_58aa_44be_a8a4_dcf77c2590c5
has only substance units: false
initial concentration: NaN
is encoded by: hsa:224
initial amount: NaN
is: SBO:0000252
is: P51648
boundary condition: true
type: Species
name: ALDH3A2
constant: false

metaR BTNDm
is: SBO:0000176
name: biotinidase (biotin), mitochondrial
notes: GENE_ASSOCIATION: (686.1) SUBSYSTEM: Biotin metabolism EC Number: 3.5.1.12 Confidence Level: 4 AUTHORS: PMID:12459313,PMID:15059618 NOTES:Also acts on biotin esters IT
kinetic law: MODEL1310110061#
fast: false
is version of: http://identifiers.org/ec-code/3.5.1.12
reversible: false
type: Reaction
is described by: ECO:0000269
product: MODEL1310110061#
modifier: MODEL1310110061#
reactant: MODEL1310110061#

http://identifiers.org/biomodels.db/MODEL1310110061#_78f41040_7fc2_43b2_852e_ba27156d88cc
has only substance units: false
is: SBO:0000252
is encoded by: hsa:R51273
name: _R51273_1_c
initial concentration: NaN
initial amount: NaN
type: Species
boundary condition: true
constant: false

metaM fadh2 c
has only substance units: false
constant: false
boundary condition: false
is: HMDB01197
initial amount: NaN
is: SBO:0000247
initial concentration: 1.0
notes: FORMULA: C27H33N9O15P2 CHARGE: -2 INCHI: InChI=1S/C27H35N9O15P2/c1-10-3-12-13(4-11(10)2)35(24-18(32-12)25(42)34-27(43)33-24)5-14(37)19(39)15(38)6-48-52(44,45)51-53(46,47)49-7-16-20(40)21(41)26(50-16)36-9-31-17-22(28)29-8-30-23(17)36/h3-4,8-9,14-16,19-21,26,32,37-41H,5-7H2,1-2H3,(H,44,45)(H,46,47)(H2,28,29,30)(H2,33,34,42,43)/p-2/t14-,15+,16+,19-,20+,21+,26+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00770 EHMN_ABBREVIATION: C01352
type: Species
name: FADH2(2-)
is: CHEBI:58307

metaR FE3R2e
kinetic law: MODEL1310110061#
notes: GENE_ASSOCIATION: (79901.1) SUBSYSTEM: Heme synthesis EC Number: Confidence Level: 4 AUTHORS: PMID:11230685,PMID:12755454 NOTES:stoichiometry unknown; inferred from EC1.16.1.7 NCD
reversible: false
reactant: MODEL1310110061#
type: Reaction
is: SBO:0000176
fast: false
name: Fe(III) reduction (ascorbate)
modifier: MODEL1310110061#
product: MODEL1310110061#
is described by: ECO:0000269

metaM HC02172 e
name: Zinc
boundary condition: false
initial amount: NaN
is: SBO:0000247
type: Species
is: CHEBI:29105
initial concentration: 1.0
notes: FORMULA: Zn CHARGE: 2 INCHI: InChI=1S/Zn/q+2
constant: false
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110061#_ae8aca88_90ca_4919_b477_cff6a45bfa27
type: Species
is: P06744
constant: false
initial amount: NaN
is encoded by: hsa:2821
name: GPI
is: SBO:0000252
initial concentration: NaN
has only substance units: false
boundary condition: true

metaM udpglcur r
initial amount: NaN
is: C00167
type: Species
is: HMDB00935
is: CHEBI:58052
boundary condition: false
notes: FORMULA: C15H19N2O18P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00162 EHMN_ABBREVIATION: C00167
initial concentration: 1.0
is: SBO:0000247
constant: false
has only substance units: false
name: UDP-D-glucuronate

metaR ACNAMlt
reactant: MODEL1310110061#
modifier: MODEL1310110061#
notes: GENE_ASSOCIATION: (26503.1) SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 4 AUTHORS: PMID:10581036,PMID:2768261 NOTES:H symport into lysososome. See PMID: 2768261 and PMID: 10581036 ( for human evidence). Sialic acid storage disorders (due to transporter mutations) require import and export e.g. PMID: 2768266 NJ
kinetic law: MODEL1310110061#
is described by: ECO:0000269
is: SBO:0000185
type: Reaction
reversible: true
fast: false
product: MODEL1310110061#
name: N-acetylneuraminate transport into lysososme

metaR CYSGLUexR
modifier: MODEL1310110061#
type: Reaction
kinetic law: MODEL1310110061#
is described by: ECO:0000304
name: L-cysteine/L-glutamine reversible exchanger
is: SBO:0000185
reversible: true
notes: GENE_ASSOCIATION: (6520.1) and (56301.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10734121,PMID:10863037,PMID:14770310 NOTES:
product: MODEL1310110061#
fast: false
reactant: MODEL1310110061#

http://identifiers.org/biomodels.db/MODEL1310110061#_abd6e9b4_76d5_4e90_9e1b_530480169c57
name: ALDH2
is encoded by: hsa:217
has only substance units: false
type: Species
is: SBO:0000252
initial amount: NaN
constant: false
is: P05091
initial concentration: NaN
boundary condition: true

metaR EX C04849 LPAREN e RPAREN
kinetic law: MODEL1310110061#
reactant: MODEL1310110061#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: (5Z,9E,14Z)-(8xi,11R,12S)-11,12-epoxy-8-hydroxyicosa-5,9,14-trienoate exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110061#_ac5ab1b2_dbe9_457e_bf64_5521c6aa8e21
constant: false
boundary condition: true
has only substance units: false
type: Species
is: SBO:0000252
is: Q16773
initial amount: NaN
name: CCBL1
initial concentration: NaN
is encoded by: hsa:883

metaM leuktrA4 c
name: leukotriene A4(1-)
constant: false
is: CHEBI:57463
boundary condition: false
initial concentration: 1.0
type: Species
notes: FORMULA: C20H29O3 CHARGE: -1 INCHI: InChI=1S/C20H30O3/c1-2-3-4-5-6-7-8-9-10-11-12-13-15-18-19(23-18)16-14-17-20(21)22/h6-7,9-13,15,18-19H,2-5,8,14,16-17H2,1H3,(H,21,22)/p-1/b7-6-,10-9-,12-11+,15-13+/t18-,19-/m0/s1 EHMN_ABBREVIATION: C00909
initial amount: NaN
has only substance units: false
is: HMDB01337
is: SBO:0000247

metaM utp c
is: HMDB00285
boundary condition: false
is: CHEBI:46398
initial amount: NaN
is: SBO:0000247
type: Species
is: C00075
notes: FORMULA: C9H11N2O15P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00077 EHMN_ABBREVIATION: C00075
has only substance units: false
constant: false
name: UTP
initial concentration: 1.0

metaR r1544
fast: false
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reversible: true
is described by: ECO:0000000
type: Reaction
is: SBO:0000185
reactant: MODEL1310110061#
product: MODEL1310110061#
kinetic law: MODEL1310110061#

http://identifiers.org/biomodels.db/MODEL1310110061#_fdcf434c_0ed6_42fc_93f9_55dbe0eecb59
is: Q7L266
type: Species
has only substance units: false
is: SBO:0000252
is encoded by: hsa:80150
initial concentration: NaN
name: ASRGL1
constant: false
boundary condition: true
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110061#_da92e62c_8748_434e_a2c2_8d709b8480eb
is: D3DWC4
is encoded by: hsa:259230
boundary condition: true
initial amount: NaN
has only substance units: false
is: SBO:0000252
name: SGMS1
type: Species
constant: false
initial concentration: NaN

metaR r2435
product: MODEL1310110061#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:1735445,PMID:18406340,PMID:1988962,PMID:2351134,PMID:2355017,PMID:6361812,PMID:7892212,PMID:8132483 NOTES:
is described by: ECO:0000000
name: Mitochondrial Carrier (MC) TCDB:2.A.29.8.3
fast: false
kinetic law: MODEL1310110061#
reactant: MODEL1310110061#
type: Reaction
reversible: false
is: SBO:0000185

metaR EX hyptaur LPAREN e RPAREN
kinetic law: MODEL1310110061#
reactant: MODEL1310110061#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: Exchange of hypotaurine
type: Reaction

metaR EX 4mop LPAREN e RPAREN
kinetic law: MODEL1310110061#
reactant: MODEL1310110061#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: Exchange of 4-methyl-2-oxopentanoate
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110061#_0c0af544_b113_479f_a562_73a287d5580b
is: SBO:0000252
type: Species
has only substance units: false
boundary condition: true
initial concentration: NaN
name: HK1
constant: false
initial amount: NaN
is encoded by: hsa:3098
is: A8K7J7

http://identifiers.org/biomodels.db/MODEL1310110061#_4255a6d5_b245_433e_a1a9_95163bfe5297
constant: false
initial amount: NaN
name: DCK
has only substance units: false
is encoded by: hsa:1633
is: SBO:0000252
is: P27707
boundary condition: true
type: Species
initial concentration: NaN

metaR VD3
name: Vitamin D3 formation
is: SBO:0000176
reactant: MODEL1310110061#
type: Reaction
fast: false
reversible: true
is described by: ECO:0000134
notes: GENE_ASSOCIATION: SUBSYSTEM: Vitamin D metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:8392061 NOTES:This reaction takes place in skin and needs body temperature based on Vitamins, G.F.M. Ball,2004, Blackwell publishing, 1st ed (book) pg.194 IT
product: MODEL1310110061#
kinetic law: MODEL1310110061#

metaR EX 5oxpro LPAREN e RPAREN
kinetic law: MODEL1310110061#
reactant: MODEL1310110061#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: Exchange of 5-oxoprolinate
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110061#_a8125a27_4124_4f93_81e3_ffd2ad308102
has only substance units: false
constant: false
initial concentration: NaN
boundary condition: true
initial amount: NaN
is: SBO:0000252
is encoded by: hsa:50814
is: Q15738
type: Species
name: NSDHL

metaM ac c
initial concentration: 1.0
is: CHEBI:30089
constant: false
is: SBO:0000247
notes: FORMULA: C2H3O2 CHARGE: -1 INCHI: InChI=1S/C2H4O2/c1-2(3)4/h1H3,(H,3,4)/p-1 HEPATONET_1.0_ABBREVIATION: HC00042 EHMN_ABBREVIATION: C00033
initial amount: NaN
boundary condition: false
has only substance units: false
name: acetate
is: HMDB00042
type: Species

metaM xoldioloneh c
is: HMDB06887
is: CHEBI:2288
initial concentration: 1.0
has only substance units: false
type: Species
initial amount: NaN
is: SBO:0000247
constant: false
notes: FORMULA: C27H46O3 CHARGE: 0 INCHI: InChI=1S/C27H46O3/c1-16(2)7-6-8-17(3)20-9-10-21-25-22(15-24(30)27(20,21)5)26(4)12-11-19(28)13-18(26)14-23(25)29/h16-18,20-25,29-30H,6-15H2,1-5H3/t17-,18+,20-,21+,22+,23-,24+,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01462 EHMN_ABBREVIATION: C05453
name: 7alpha,12alpha-dihydroxy-5beta-cholestan-3-one
boundary condition: false

metaR r1650
kinetic law: MODEL1310110061#
product: MODEL1310110061#
modifier: MODEL1310110061#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is described by: ECO:0000000
type: Reaction
reactant: MODEL1310110061#
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
fast: false
reversible: true
is: SBO:0000185

metaM h2o l
notes: FORMULA: H2O CHARGE: 0 INCHI: InChI=1S/H2O/h1H2 HEPATONET_1.0_ABBREVIATION: HC00011 EHMN_ABBREVIATION: C00001
is: SBO:0000247
initial concentration: 1.0
has only substance units: false
is: CHEBI:15377
boundary condition: false
name: water
initial amount: NaN
is: HMDB02111
constant: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110061#_35c74737_d784_461e_a29d_20bf88837157
is: SBO:0000252
boundary condition: true
constant: false
is: Q4J699
has only substance units: false
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:491
name: ATP2B2
type: Species

http://identifiers.org/biomodels.db/MODEL1310110061#_ea890a03_a49e_4ab3_9467_df53d5db0ddc
name: PLA2G10
is: O15496
initial amount: NaN
initial concentration: NaN
type: Species
constant: false
is encoded by: hsa:8399
is: SBO:0000252
boundary condition: true
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110061#_433bf7dc_30b6_4d88_9a2e_60f597999714
name: RDH5
type: Species
boundary condition: true
has only substance units: false
is: SBO:0000252
is: Q92781
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:5959
constant: false

metaM 3pg m
initial amount: NaN
has only substance units: false
notes: FORMULA: C3H4O7P CHARGE: -3 INCHI: InChI=1S/C3H7O7P/c4-2(3(5)6)1-10-11(7,8)9/h2,4H,1H2,(H,5,6)(H2,7,8,9)/p-3/t2-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00186 EHMN_ABBREVIATION: C00197
initial concentration: 1.0
constant: false
is: SBO:0000247
is: HMDB00807
name: (2R)-2-hydroxy-3-(phosphonatooxy)propanoate
type: Species
boundary condition: false
is: CHEBI:58272

metaM 2hexdtetcoa m
is: HMDB02288
initial amount: NaN
name: 2,7,10,13-hexadecatetraenoylcoa
type: Species
is: SBO:0000247
has only substance units: false
notes: FORMULA: C37H54N7O17P3S CHARGE: -4
initial concentration: 1.0
constant: false
boundary condition: false

metaR FACOAL245 1
reactant: MODEL1310110061#
name: fatty-acid--CoA ligase
kinetic law: MODEL1310110061#
type: Reaction
reversible: true
modifier: MODEL1310110061#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (2180.1) SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 4 AUTHORS: PMID:15292367 NOTES:NJ
product: MODEL1310110061#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/6.2.1.3
fast: false

http://identifiers.org/biomodels.db/MODEL1310110061#_72d02cfe_6114_4ea0_ab39_6c1e1204c139
initial amount: NaN
has only substance units: false
initial concentration: NaN
boundary condition: true
constant: false
is: SBO:0000252
name: UGP2
is: Q16851
is encoded by: hsa:7360
type: Species

metaR 3MOPte
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
type: Reaction
product: MODEL1310110061#
is: SBO:0000185
reactant: MODEL1310110061#
name: Transport of 3-methyl-2-oxopentanoate
is described by: ECO:0000134
fast: false
kinetic law: MODEL1310110061#

http://identifiers.org/biomodels.db/MODEL1310110061#_137a20c2_dc7c_40b8_93aa_0899bd22dc13
initial concentration: NaN
is encoded by: hsa:65010
constant: false
is: SBO:0000252
type: Species
initial amount: NaN
is: Q9NQU1
name: SLC26A6
boundary condition: true
has only substance units: false

metaR DCT
name: Dopachrome tautomerase
is: SBO:0000176
fast: false
is version of: http://identifiers.org/ec-code/5.3.3.12
is described by: ECO:0000269
type: Reaction
kinetic law: MODEL1310110061#
notes: GENE_ASSOCIATION: (1638.1) SUBSYSTEM: Tyrosine metabolism EC Number: 5.3.3.12 Confidence Level: 4 AUTHORS: PMID:8148378 NOTES:ISOMERASE SAB added EC and adjusted compounds for balance
modifier: MODEL1310110061#
product: MODEL1310110061#
reversible: true
reactant: MODEL1310110061#

metaR r0655
product: MODEL1310110061#
notes: GENE_ASSOCIATION: (10637.1) or (5831.1) or (29920.1) or (65263.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 1.3.99.10 Confidence Level: 0 AUTHORS: PMID:3597357,PMID:9214289 NOTES:
reactant: MODEL1310110061#
is described by: ECO:0000000
kinetic law: MODEL1310110061#
reversible: true
type: Reaction
modifier: MODEL1310110061#
is: SBO:0000176
name: 3-Methylbutanoyl-CoA:(acceptor) 2,3-oxidoreductase Valine, leucine and isoleucine degradation EC:1.3.99.10
is version of: http://identifiers.org/ec-code/1.5.1.2
fast: false

http://identifiers.org/biomodels.db/MODEL1310110061#_ecf9cd16_6da2_4a14_b84a_7336631dfd19
is encoded by: hsa:11046
is: Q76EJ3
boundary condition: true
type: Species
initial concentration: NaN
name: SLC35D2
constant: false
initial amount: NaN
is: SBO:0000252
has only substance units: false

metaM 3dsphgn c
constant: false
initial concentration: 1.0
is: SBO:0000247
initial amount: NaN
name: (2S)-1-hydroxy-3-oxooctadecan-2-aminium
type: Species
is: HMDB01480
has only substance units: false
is: CHEBI:58299
notes: FORMULA: C18H38NO2 CHARGE: 1 INCHI: InChI=1S/C18H37NO2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-18(21)17(19)16-20/h17,20H,2-16,19H2,1H3/p+1/t17-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01019 EHMN_ABBREVIATION: C02934
boundary condition: false

metaR GTHP
reactant: MODEL1310110061#
notes: GENE_ASSOCIATION: (7001.3) or (5052.3) or (2877.1) or (2876.2) or (5052.2) or (2876.1) or (5052.1) or (7001.1) or (2879.1) or (7001.2) SUBSYSTEM: Glutathione metabolism EC Number: 1.11.1.9 Confidence Level: 4 AUTHORS: PMID:15802613,PMID:17015272,PMID:17015273 NOTES:NCD
is described by: ECO:0000134
type: Reaction
is version of: http://identifiers.org/ec-code/1.11.1.12
reversible: true
is version of: http://identifiers.org/ec-code/1.11.1.9
kinetic law: MODEL1310110061#
fast: false
modifier: MODEL1310110061#
name: glutathione peroxidase
is version of: http://identifiers.org/ec-code/1.11.1.15
product: MODEL1310110061#
is: SBO:0000176

metaR r2437
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:1735445,PMID:18406340,PMID:1988962,PMID:2351134,PMID:2355017,PMID:6361812,PMID:7892212,PMID:8132483 NOTES:
reversible: false
reactant: MODEL1310110061#
product: MODEL1310110061#
is: SBO:0000185
type: Reaction
kinetic law: MODEL1310110061#
name: Mitochondrial Carrier (MC) TCDB:2.A.29.8.3
is described by: ECO:0000000

metaM h2o m
boundary condition: false
type: Species
is: SBO:0000247
name: H2O
initial amount: NaN
has only substance units: false
notes: FORMULA: H2O CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00011 EHMN_ABBREVIATION: C00001
initial concentration: 1.0
is: CHEBI:15377
constant: false
is: C00001
is: HMDB02111

metaR P4507A1r
is version of: http://identifiers.org/ec-code/1.14.13.17
kinetic law: MODEL1310110061#
notes: GENE_ASSOCIATION: (1581.1) SUBSYSTEM: Bile acid synthesis EC Number: 1.14.13.17 Confidence Level: 4 AUTHORS: NOTES:
is: SBO:0000176
product: MODEL1310110061#
type: Reaction
is described by: ECO:0000269
fast: false
reversible: false
reactant: MODEL1310110061#
modifier: MODEL1310110061#
name: cytochrome P450, family 7, subfamily A, polypeptide 1

metaR r1651
is: SBO:0000185
is described by: ECO:0000000
type: Reaction
modifier: MODEL1310110061#
reactant: MODEL1310110061#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reversible: true
kinetic law: MODEL1310110061#
product: MODEL1310110061#
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
fast: false

metaM accoa x
is: SBO:0000247
is: HMDB01206
constant: false
has only substance units: false
is: C00024
notes: FORMULA: C23H34N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00033 EHMN_ABBREVIATION: C00024
initial amount: NaN
name: Acetyl-CoA
initial concentration: 1.0
type: Species
is: CHEBI:57288
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110061#_f4ac9e14_06c7_4c4f_ac9d_43300bc68bca
constant: false
initial amount: NaN
is: SBO:0000252
name: LDHD
type: Species
has only substance units: false
is encoded by: hsa:197257
boundary condition: true
initial concentration: NaN

metaM HC00695 m
boundary condition: false
initial amount: NaN
notes: FORMULA: C12H20NO4S2 CHARGE: -1 INCHI: InChI=1S/C12H21NO4S2/c13-10(14)4-2-1-3-9(18)7-8-19-12(17)6-5-11(15)16/h9,18H,1-8H2,(H2,13,14)(H,15,16) EHMN_ABBREVIATION: C01169
is: CHEBI:17432
constant: false
has only substance units: false
name: S-Succinyldihydrolipoamide
type: Species
initial concentration: 1.0
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110061#_b91bf7e8_b960_4bd4_bed4_faf54bfceecb
type: Species
is: Q9BYV1
constant: false
is: SBO:0000252
has only substance units: false
name: AGXT2
initial amount: NaN
is encoded by: hsa:64902
boundary condition: true
initial concentration: NaN

metaR B3GALT3g
notes: GENE_ASSOCIATION: (8706.4) or (8706.1) or (8706.3) or (8706.2) SUBSYSTEM: Sphingolipid metabolism EC Number: 2.4.1.79 Confidence Level: 4 AUTHORS: NOTES:NJ
is: SBO:0000176
product: MODEL1310110061#
is described by: ECO:0000269
fast: false
reversible: false
is version of: http://identifiers.org/ec-code/2.4.1.79
name: Beta-1,3-galactosyltransferase 3
modifier: MODEL1310110061#
kinetic law: MODEL1310110061#
reactant: MODEL1310110061#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110061#_d9b1cfe2_21ce_49b4_b45d_ae3ae2fed80b
name: _BG035985_1_c
has only substance units: false
type: Species
initial amount: NaN
is encoded by: hsa:BG035985
initial concentration: NaN
is: SBO:0000252
constant: false
boundary condition: true

metaR PRASCS
reversible: true
product: MODEL1310110061#
notes: GENE_ASSOCIATION: (10606.1) SUBSYSTEM: Purine synthesis EC Number: Confidence Level: 4 AUTHORS: NOTES:
is: SBO:0000176
type: Reaction
fast: false
modifier: MODEL1310110061#
is version of: http://identifiers.org/ec-code/6.3.2.6
is described by: ECO:0000269
kinetic law: MODEL1310110061#
reactant: MODEL1310110061#
name: phosphoribosylaminoimidazolesuccinocarboxamide synthase

metaR r1546
kinetic law: MODEL1310110061#
reversible: true
product: MODEL1310110061#
is: SBO:0000185
is described by: ECO:0000000
type: Reaction
reactant: MODEL1310110061#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1

http://identifiers.org/biomodels.db/MODEL1310110061#_ffacae78_6ff2_417f_a510_76567b56edfc
has only substance units: false
is encoded by: hsa:5091
name: PC
type: Species
initial concentration: NaN
is: P11498
boundary condition: true
initial amount: NaN
is: SBO:0000252
constant: false

metaM orot5p c
initial amount: NaN
is: C01103
type: Species
is: HMDB00218
name: Orotidine 5'-phosphate
constant: false
is: CHEBI:57538
boundary condition: false
initial concentration: 1.0
is: SBO:0000247
has only substance units: false
notes: FORMULA: C10H10N2O11P CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00669 EHMN_ABBREVIATION: C01103

metaR EICOSTETt
type: Reaction
product: MODEL1310110061#
reversible: true
name: fatty acid transport via diffusion
is: SBO:0000185
kinetic law: MODEL1310110061#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11788354,PMID:12864740 NOTES:NJ
is described by: ECO:0000000
reactant: MODEL1310110061#
fast: false

metaM leuktrA4 e
boundary condition: false
type: Species
name: leukotriene A4(1-)
is: SBO:0000247
notes: FORMULA: C20H29O3 CHARGE: -1 INCHI: InChI=1S/C20H30O3/c1-2-3-4-5-6-7-8-9-10-11-12-13-15-18-19(23-18)16-14-17-20(21)22/h6-7,9-13,15,18-19H,2-5,8,14,16-17H2,1H3,(H,21,22)/p-1/b7-6-,10-9-,12-11+,15-13+/t18-,19-/m0/s1 EHMN_ABBREVIATION: C00909
has only substance units: false
constant: false
is: CHEBI:57463
initial amount: NaN
initial concentration: 1.0
is: HMDB01337

metaR PPD2CSPp
is: SBO:0000176
type: Reaction
product: MODEL1310110061#
kinetic law: MODEL1310110061#
fast: false
reversible: false
reactant: MODEL1310110061#
name: PPD2CSPp
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Lysine metabolism EC Number: Confidence Level: 2 AUTHORS: PMID:10485319,PMID:10772957 NOTES:spontaneous cyclization reaction MM

http://identifiers.org/biomodels.db/MODEL1310110061#_cf4ee70b_8aa2_4f4c_866d_c910f671d12a
is encoded by: hsa:3550
is: SBO:0000252
name: IK
has only substance units: false
constant: false
initial amount: NaN
type: Species
initial concentration: NaN
boundary condition: true
is: Q13123

metaR CREATt4 2 r
is: SBO:0000185
type: Reaction
modifier: MODEL1310110061#
is described by: ECO:0000269
reversible: true
notes: GENE_ASSOCIATION: (6535.1) or (386757.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12719981 NOTES:SAB
fast: false
kinetic law: MODEL1310110061#
name: Creatine transport (sodium symport) (2:1)
product: MODEL1310110061#
reactant: MODEL1310110061#

metaR r0074
type: Reaction
modifier: MODEL1310110061#
reactant: MODEL1310110061#
name: L-Glutamate 5-semialdehyde:NAD+ oxidoreductase Arginine and proline metabolism EC:1.5.1.12
is described by: ECO:0000000
fast: false
notes: GENE_ASSOCIATION: (84532.1) or (55902.1) SUBSYSTEM: Urea cycle EC Number: 1.5.1.12 Confidence Level: 0 AUTHORS: PMID:1286669,PMID:2211729 NOTES:
kinetic law: MODEL1310110061#
reversible: true
product: MODEL1310110061#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/6.2.1.1

metaR CYTK4n
is described by: ECO:0000269
reversible: true
type: Reaction
product: MODEL1310110061#
fast: false
kinetic law: MODEL1310110061#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.7.4.14
modifier: MODEL1310110061#
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
reactant: MODEL1310110061#
name: cytidylate kinase (dCMP,GTP),nuclear

http://identifiers.org/biomodels.db/MODEL1310110061#_c124b9df_5ee0_4d37_81c1_6ed1eace3f77
has only substance units: false
type: Species
boundary condition: true
is: SBO:0000252
is: P19404
constant: false
is encoded by: hsa:4729
name: NDUFV2
initial concentration: NaN
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110061#_b1af9b3e_f5b0_4d93_9db6_7cf9d128100b
initial amount: NaN
is encoded by: hsa:9162
name: DGKI
boundary condition: true
initial concentration: NaN
is: SBO:0000252
constant: false
has only substance units: false
type: Species
is: O75912

metaR GTHO
product: MODEL1310110061#
is: SBO:0000176
name: glutathione oxidoreductase
reactant: MODEL1310110061#
notes: GENE_ASSOCIATION: (2936.1) SUBSYSTEM: Glutamate metabolism EC Number: 1.8.1.7 Confidence Level: 2 AUTHORS: PMID:10708558 NOTES:NCD, TV This EC (1.6.4.2) is obsolete. The new EC is 1.8.1.7. http://www.genome.ad.jp/dbget-bin/www_bget?ec:1.6.4.2
is described by: ECO:0000254
modifier: MODEL1310110061#
fast: false
type: Reaction
is version of: http://identifiers.org/ec-code/1.8.1.7
reversible: false
kinetic law: MODEL1310110061#

metaR THBPT4ACAMDASE
fast: false
kinetic law: MODEL1310110061#
name: Tetrahydrobiopterin-4a-carbinolamine dehydratase
notes: GENE_ASSOCIATION: (5092.1) or (5092.2) SUBSYSTEM: Tetrahydrobiopterin metabolism EC Number: 4.2.1.96 Confidence Level: 4 AUTHORS: PMID:10727395 NOTES:SAB based on PMID 10727395
is version of: http://identifiers.org/ec-code/4.2.1.96
is described by: ECO:0000269
reactant: MODEL1310110061#
reversible: false
type: Reaction
product: MODEL1310110061#
is: SBO:0000176
modifier: MODEL1310110061#

metaR INOSTO
modifier: MODEL1310110061#
reversible: false
name: inositol oxygenase
is version of: http://identifiers.org/ec-code/1.13.99.1
notes: GENE_ASSOCIATION: (55586.1) SUBSYSTEM: Inositol phosphate metabolism EC Number: 1.13.99.1 Confidence Level: 4 AUTHORS: PMID:15504367 NOTES:NCD
is: SBO:0000176
reactant: MODEL1310110061#
fast: false
product: MODEL1310110061#
type: Reaction
is described by: ECO:0000269
kinetic law: MODEL1310110061#

http://identifiers.org/biomodels.db/MODEL1310110061#_98a5eb0a_82c0_461b_9c96_60f8f044a6b0
initial concentration: NaN
initial amount: NaN
boundary condition: true
is: P55084
constant: false
has only substance units: false
type: Species
name: HADHB
is: SBO:0000252
is encoded by: hsa:3032

http://identifiers.org/biomodels.db/MODEL1310110061#_df4cfb59_2c46_4f0c_9504_817fa8a65d72
is encoded by: hsa:6576
initial concentration: NaN
type: Species
has only substance units: false
name: SLC25A1
initial amount: NaN
is: D9HTE9
boundary condition: true
is: SBO:0000252
constant: false

metaR r1652
fast: false
kinetic law: MODEL1310110061#
is described by: ECO:0000000
type: Reaction
reversible: true
reactant: MODEL1310110061#
is: SBO:0000185
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
product: MODEL1310110061#
modifier: MODEL1310110061#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1

metaR DINt
is described by: ECO:0000000
reactant: MODEL1310110061#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10899995 NOTES:
fast: false
product: MODEL1310110061#
reversible: true
is: SBO:0000185
kinetic law: MODEL1310110061#
type: Reaction
name: deoxyinosine transport via diffusion

metaM h2o n
notes: FORMULA: H2O CHARGE: 0 INCHI: InChI=1S/H2O/h1H2 HEPATONET_1.0_ABBREVIATION: HC00011 EHMN_ABBREVIATION: C00001
initial concentration: 1.0
is: CHEBI:15377
initial amount: NaN
is: HMDB02111
has only substance units: false
boundary condition: false
name: water
constant: false
type: Species
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110061#_8754368c_7042_4b5c_879b_b98ad847b038
is: SBO:0000252
boundary condition: true
initial amount: NaN
name: AMY2B
is encoded by: hsa:280
is: P19961
type: Species
has only substance units: false
constant: false
initial concentration: NaN

metaR ARACHDtr
reactant: MODEL1310110061#
type: Reaction
fast: false
kinetic law: MODEL1310110061#
reversible: true
product: MODEL1310110061#
name: intracellular transport
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: NOTES:unknown mechanism, presumed diffusion NJ
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110061#_e96a3982_e661_48a1_9719_2aa12e8556b2
is: B4E3E9
boundary condition: true
initial amount: NaN
is: SBO:0000252
initial concentration: NaN
is encoded by: hsa:4967
name: OGDH
type: Species
has only substance units: false
constant: false

metaM HC00822 l
is: CHEBI:28681
is: SBO:0000247
boundary condition: false
notes: FORMULA: C16H28N2O11 CHARGE: 0 INCHI: InChI=1S/C16H28N2O11/c1-5(21)17-9-13(25)14(8(4-20)27-15(9)26)29-16-10(18-6(2)22)12(24)11(23)7(3-19)28-16/h7-16,19-20,23-26H,3-4H2,1-2H3,(H,17,21)(H,18,22)/t7-,8-,9-,10-,11-,12-,13-,14-,15?,16+/m1/s1 EHMN_ABBREVIATION: C01674
constant: false
initial amount: NaN
type: Species
has only substance units: false
name: Chitobiose
initial concentration: 1.0

metaR GLYt7 311 r
kinetic law: MODEL1310110061#
type: Reaction
fast: false
notes: GENE_ASSOCIATION: (9152.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12719981 NOTES:SAB
product: MODEL1310110061#
is: SBO:0000185
is described by: ECO:0000006
reactant: MODEL1310110061#
modifier: MODEL1310110061#
name: glycine reversible transport via sodium and chloride symport (3:1:1)
reversible: true

metaM ac e
has only substance units: false
name: acetate
constant: false
is: CHEBI:30089
initial concentration: 1.0
is: SBO:0000247
initial amount: NaN
notes: FORMULA: C2H3O2 CHARGE: -1 INCHI: InChI=1S/C2H4O2/c1-2(3)4/h1H3,(H,3,4)/p-1 HEPATONET_1.0_ABBREVIATION: HC00042 EHMN_ABBREVIATION: C00033
boundary condition: false
is: HMDB00042
type: Species

metaR EX rbt LPAREN e RPAREN
kinetic law: MODEL1310110061#
reactant: MODEL1310110061#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Ribitol exchange
type: Reaction

metaM mal L c
is: CHEBI:15589
is: HMDB00156
notes: FORMULA: C4H4O5 CHARGE: -2 INCHI: InChI=1S/C4H6O5/c5-2(4(8)9)1-3(6)7/h2,5H,1H2,(H,6,7)(H,8,9)/p-2/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00146
initial concentration: 1.0
is: SBO:0000247
name: (S)-malate(2-)
has only substance units: false
constant: false
boundary condition: false
initial amount: NaN
type: Species

metaR r1547
product: MODEL1310110061#
is described by: ECO:0000000
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
type: Reaction
reactant: MODEL1310110061#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is: SBO:0000185
kinetic law: MODEL1310110061#
reversible: true
fast: false

metaR RE0383C
is: SBO:0000176
product: MODEL1310110061#
reactant: MODEL1310110061#
type: Reaction
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (10327.1) SUBSYSTEM: Miscellaneous EC Number: 1.1.1.2 Confidence Level: 0 AUTHORS: PMID:1748675 NOTES:
reversible: true
kinetic law: MODEL1310110061#
modifier: MODEL1310110061#
is version of: http://identifiers.org/ec-code/1.1.1.2
fast: false
name: RE0383

metaM ac m
is: CHEBI:30089
constant: false
is: HMDB00042
initial concentration: 1.0
notes: FORMULA: C2H3O2 CHARGE: -1 INCHI: InChI=1S/C2H4O2/c1-2(3)4/h1H3,(H,3,4)/p-1 HEPATONET_1.0_ABBREVIATION: HC00042 EHMN_ABBREVIATION: C00033
boundary condition: false
initial amount: NaN
is: SBO:0000247
has only substance units: false
type: Species
name: acetate

http://identifiers.org/biomodels.db/MODEL1310110061#_89475b3e_e892_4a94_b134_52daa8175cda
initial concentration: NaN
constant: false
has only substance units: false
initial amount: NaN
name: ACOT4
boundary condition: true
is: SBO:0000252
is: Q8N9L9
is encoded by: hsa:122970
type: Species

metaR r0754
is: SBO:0000176
reversible: true
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (2194.1) SUBSYSTEM: Unassigned EC Number: 1.2.1.5 Confidence Level: 0 AUTHORS: PMID:17379813,PMID:18621017 NOTES:
modifier: MODEL1310110061#
kinetic law: MODEL1310110061#
is version of: http://identifiers.org/ec-code/2.3.1.85
fast: false
reactant: MODEL1310110061#
type: Reaction
product: MODEL1310110061#
name: 3-Methoxy-4-hydroxyphenylacetaldehyde:NAD+ oxidoreductase Tyrosine metabolism EC:1.2.1.5

metaR APOCFm
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Biotin metabolism EC Number: Confidence Level: 2 AUTHORS: NOTES:IT faked reaction to balance reaction in human biotin metabolism
is: SBO:0000176
product: MODEL1310110061#
fast: false
reactant: MODEL1310110061#
reversible: false
kinetic law: MODEL1310110061#
name: Apocarboxylase formation, mitochondrial
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110061#_ccd62c39_8182_4422_a89b_84f0b240e85f
initial amount: NaN
name: FOLR1
is: SBO:0000252
boundary condition: true
type: Species
initial concentration: NaN
is encoded by: hsa:2348
has only substance units: false
constant: false

metaM nadp m
notes: FORMULA: C21H25N7O17P3 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00016 EHMN_ABBREVIATION: C00006
name: Nicotinamide adenine dinucleotide phosphate
is: SBO:0000247
initial amount: NaN
has only substance units: false
constant: false
initial concentration: 1.0
is: C00006
is: HMDB00217
is: CHEBI:58349
boundary condition: false
type: Species

metaM adrn c
constant: false
notes: FORMULA: C22H35O2 CHARGE: -1 INCHI: InChI=1S/C22H36O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22(23)24/h6-7,9-10,12-13,15-16H,2-5,8,11,14,17-21H2,1H3,(H,23,24)/b7-6-,10-9-,13-12-,16-15-
initial concentration: 1.0
is: CHEBI:53487
boundary condition: false
type: Species
name: adrenic acid
has only substance units: false
is: SBO:0000247
initial amount: NaN
is: HMDB02226

http://identifiers.org/biomodels.db/MODEL1310110061#_e86137c6_40fc_4345_8f6f_962de8983489
is: Q9Y6M9
type: Species
is encoded by: hsa:4715
initial concentration: NaN
name: NDUFB9
has only substance units: false
initial amount: NaN
constant: false
is: SBO:0000252
boundary condition: true

metaR r1397
fast: false
reversible: false
kinetic law: MODEL1310110061#
product: MODEL1310110061#
name: carnitine acetyltransferase EC:2.3.1.7
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.7 Confidence Level: 0 AUTHORS: PMID:12133002,PMID:4475632,PMID:5810070 NOTES:
type: Reaction
reactant: MODEL1310110061#
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110061#_e6c649f7_9915_4c98_a920_253751ce2f34
type: Species
initial amount: NaN
is encoded by: hsa:1103
is: D3DX95
initial concentration: NaN
name: CHAT
has only substance units: false
boundary condition: true
constant: false
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110061#_e1954bea_c882_4a33_a4a0_99d5b6a692f3
is: SBO:0000252
boundary condition: true
name: HIBCH
type: Species
is: Q6NVY1
initial concentration: NaN
initial amount: NaN
constant: false
has only substance units: false
is encoded by: hsa:26275

metaR ALASm
notes: GENE_ASSOCIATION: (212.1) or (23464.1) or (211.2) or (211.1) SUBSYSTEM: Glycine, serine, alanine and threonine metabolism EC Number: 2.3.1.37 Confidence Level: 2 AUTHORS: PMID:2263504 NOTES:NCD
name: 5-aminolevulinate synthase
is: SBO:0000176
is described by: ECO:0000254
modifier: MODEL1310110061#
fast: false
type: Reaction
product: MODEL1310110061#
reactant: MODEL1310110061#
is version of: http://identifiers.org/ec-code/2.3.1.29
reversible: false
is version of: http://identifiers.org/ec-code/2.3.1.37
kinetic law: MODEL1310110061#

metaM crm hs c
type: Species
initial amount: NaN
boundary condition: false
is: SBO:0000247
notes: FORMULA: C18H36NO2FULLRCO CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC01990 EHMN_ABBREVIATION: C00195
constant: false
has only substance units: false
is: CHEBI:52639
initial concentration: 1.0
name: N-acylsphingosine

metaR FE2t
name: iron (II) transport
type: Reaction
reactant: MODEL1310110061#
kinetic law: MODEL1310110061#
is: SBO:0000185
reversible: false
is described by: ECO:0000000
product: MODEL1310110061#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12440707 NOTES:
fast: false

http://identifiers.org/biomodels.db/MODEL1310110061#_315d1cda_f0e8_45b8_90b7_a9b90667bfc2
has only substance units: false
name: ME2
constant: false
boundary condition: true
type: Species
is: P23368
is encoded by: hsa:4200
initial concentration: NaN
initial amount: NaN
is: SBO:0000252

metaR MTHFC
modifier: MODEL1310110061#
reactant: MODEL1310110061#
is version of: http://identifiers.org/ec-code/3.5.4.9
reversible: true
is: SBO:0000176
kinetic law: MODEL1310110061#
type: Reaction
fast: false
notes: GENE_ASSOCIATION: (4522.1) or (100287639.1) or (441024.1) SUBSYSTEM: Folate metabolism EC Number: 3.5.4.9 Confidence Level: 4 AUTHORS: PMID:2786332 NOTES:Human Y/N: Y
product: MODEL1310110061#
is described by: ECO:0000134
name: methenyltetrahydrofolate cyclohydrolase
is version of: http://identifiers.org/ec-code/1.5.1.5

metaM C05965 e
initial amount: NaN
initial concentration: 1.0
is: SBO:0000247
name: 12(S)-HPETE(1-)
constant: false
is: HMDB04243
type: Species
has only substance units: false
notes: FORMULA: C20H31O4 CHARGE: -1 INCHI: InChI=1S/C20H32O4/c1-2-3-4-5-10-13-16-19(24-23)17-14-11-8-6-7-9-12-15-18-20(21)22/h7-11,13-14,17,19,23H,2-6,12,15-16,18H2,1H3,(H,21,22)/p-1/b9-7-,11-8-,13-10-,17-14+/t19-/m0/s1 EHMN_ABBREVIATION: C05965
boundary condition: false
is: CHEBI:57444

metaR r0224
is: SBO:0000176
modifier: MODEL1310110061#
notes: GENE_ASSOCIATION: (6576.1) SUBSYSTEM: Folate metabolism EC Number: 1.5.1.3 Confidence Level: 0 AUTHORS: PMID:15153070,PMID:1631094,PMID:6882460 NOTES:
is described by: ECO:0000000
name: 5,6,7,8-Tetrahydrofolate:NAD+ oxidoreductase One carbon pool by folate EC:1.5.1.3
kinetic law: MODEL1310110061#
reactant: MODEL1310110061#
reversible: false
type: Reaction
fast: false
product: MODEL1310110061#

metaR OROTGLUt
name: OROTGLUt
product: MODEL1310110061#
fast: false
is: SBO:0000185
kinetic law: MODEL1310110061#
type: Reaction
reversible: true
reactant: MODEL1310110061#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134

metaM o2 r
is: C00007
is: HMDB01377
type: Species
name: O2
is: SBO:0000247
initial concentration: 1.0
initial amount: NaN
is: CHEBI:15379
constant: false
boundary condition: false
notes: FORMULA: O2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00017 EHMN_ABBREVIATION: C00007
has only substance units: false

metaR COUCOAFm
is described by: ECO:0000000
type: Reaction
fast: false
kinetic law: MODEL1310110061#
notes: GENE_ASSOCIATION: SUBSYSTEM: Ubiquinone synthesis EC Number: 6.2.1.12 Confidence Level: 2 AUTHORS: PMID:11583838,PMID:12232327 NOTES:IT reaction involved in formation of 4-hydroxybenzoate from tyrosine. (EC 6.2.1.12) .
reactant: MODEL1310110061#
is: SBO:0000176
reversible: false
name: p-coumaroyl-CoA formation
product: MODEL1310110061#

metaR r0755
kinetic law: MODEL1310110061#
reactant: MODEL1310110061#
type: Reaction
name: 3-Methoxy-4-hydroxyphenylacetaldehyde:NADP+ oxidoreductase Tyrosine metabolism EC:1.2.1.5
product: MODEL1310110061#
modifier: MODEL1310110061#
fast: false
notes: GENE_ASSOCIATION: (27034.1) or (28976.1) or (37.1) SUBSYSTEM: Unassigned EC Number: 1.2.1.5 Confidence Level: 0 AUTHORS: PMID:1898068 NOTES:
is: SBO:0000176
reversible: true
is described by: ECO:0000000

metaM cl c
has only substance units: false
initial concentration: 1.0
is: SBO:0000247
notes: FORMULA: Cl CHARGE: -1
is: HMDB00492
is: CHEBI:3966
constant: false
name: Chloride
boundary condition: false
initial amount: NaN
is: C00115
type: Species

metaM pi e
is: CHEBI:43474
type: Species
constant: false
is: SBO:0000247
notes: FORMULA: HO4P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00019 EHMN_ABBREVIATION: C00009
boundary condition: false
initial concentration: 1.0
name: hydrogenphosphate
is: C00009
has only substance units: false
initial amount: NaN
is: HMDB00973

http://identifiers.org/biomodels.db/MODEL1310110061#_c3ebd748_81a2_44b3_932f_b8b4180cba98
has only substance units: false
type: Species
boundary condition: true
initial amount: NaN
is: Q9BZ23
is: SBO:0000252
constant: false
name: PANK2
initial concentration: NaN
is encoded by: hsa:80025

metaR CYTK13n
is described by: ECO:0000269
fast: false
is: SBO:0000176
reactant: MODEL1310110061#
modifier: MODEL1310110061#
reversible: true
kinetic law: MODEL1310110061#
is version of: http://identifiers.org/ec-code/2.7.4.14
name: cytidylate kinase (dCMP,dATP),nuclear
product: MODEL1310110061#
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
type: Reaction

metaR PNTOte
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
reversible: true
is: SBO:0000185
reactant: MODEL1310110061#
name: Transport of (R)-Pantothenate
kinetic law: MODEL1310110061#
type: Reaction
product: MODEL1310110061#
fast: false

http://identifiers.org/biomodels.db/MODEL1310110061#_175c2445_cf52_41ae_bb1d_26140dbec264
name: TXNRD1
is: SBO:0000252
has only substance units: false
initial amount: NaN
is encoded by: hsa:7296
boundary condition: true
constant: false
type: Species
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110061#_30b94817_2784_4c27_b731_370b71685341
constant: false
name: HSD17B4
is encoded by: hsa:3295
is: E9PB82
initial amount: NaN
is: SBO:0000252
initial concentration: NaN
has only substance units: false
boundary condition: true
type: Species

http://identifiers.org/biomodels.db/MODEL1310110061#_09f336a8_3463_4aa6_9f51_d763d198a1ac
boundary condition: true
is encoded by: hsa:10317
is: SBO:0000252
name: B3GALT5
initial amount: NaN
has only substance units: false
type: Species
initial concentration: NaN
constant: false

metaR PYK
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.7.1.40
product: MODEL1310110061#
reactant: MODEL1310110061#
type: Reaction
notes: GENE_ASSOCIATION: (5315.2) or (5313.2) or (5315.3) or (5313.1) or (113452.1) or (5315.1) SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: Confidence Level: 0 AUTHORS: NOTES:
modifier: MODEL1310110061#
kinetic law: MODEL1310110061#
name: pyruvate kinase
is described by: ECO:0000134
fast: false
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110061#_82b771d5_821e_40d2_96d9_f6282c0af06c
name: RPIA
is: SBO:0000252
is encoded by: hsa:22934
initial concentration: NaN
initial amount: NaN
type: Species
boundary condition: true
constant: false
is: P49247
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110061#_2c8092b2_f118_431d_9e88_c7b9e4069879
has only substance units: false
constant: false
initial amount: NaN
is: Q53Y25
name: GCK
initial concentration: NaN
is: SBO:0000252
type: Species
boundary condition: true
is encoded by: hsa:2645

http://identifiers.org/biomodels.db/MODEL1310110061#_20534c6e_5252_4349_a65b_a63b93bded7a
is: SBO:0000252
has only substance units: false
initial concentration: NaN
name: COX4I1
is: P13073
initial amount: NaN
boundary condition: true
is encoded by: hsa:1327
constant: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110061#_e285eac1_7a4d_49fb_8d31_ff71d1e9e4db
initial amount: NaN
is encoded by: hsa:89869
initial concentration: NaN
has only substance units: false
is: SBO:0000252
name: PLCZ1
constant: false
boundary condition: true
type: Species
is: Q86YW0

metaR r1396
kinetic law: MODEL1310110061#
name: EC:2.3.1.21
reversible: false
product: MODEL1310110061#
fast: false
is described by: ECO:0000000
type: Reaction
reactant: MODEL1310110061#
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.21 Confidence Level: 0 AUTHORS: PMID:12133002,PMID:4475632,PMID:5810070 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110061#_7e95d9a1_510a_4446_9649_ef47d730f63f
initial amount: NaN
name: _R33828_1_c
type: Species
initial concentration: NaN
is encoded by: hsa:R33828
constant: false
has only substance units: false
boundary condition: true
is: SBO:0000252

metaR NDPK1m
is described by: ECO:0000254
reactant: MODEL1310110061#
type: Reaction
notes: GENE_ASSOCIATION: (4833.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.6 Confidence Level: 2 AUTHORS: PMID:9099850 NOTES:Many nucleoside diphosphates (eight described) can act as acceptors. While many ribo- and deoxyribonucleoside triphosphates can act as donors, only ATP is chosen as a donor to minimize the number of total reactions.
kinetic law: MODEL1310110061#
is: SBO:0000176
modifier: MODEL1310110061#
reversible: true
product: MODEL1310110061#
is version of: http://identifiers.org/ec-code/2.7.4.6
fast: false
name: nucleoside-diphosphate kinase (ATP:GDP), mitochondrial

metaM apoC Lys c
type: Species
notes: FORMULA: C6H13N2OX CHARGE: 0
is: CHEBI:32551
initial concentration: 1.0
name: Apocarboxylase (Lys residue)
is: SBO:0000247
has only substance units: false
initial amount: NaN
boundary condition: false
constant: false
is: HMDB00182

metaR CTPS1
kinetic law: MODEL1310110061#
product: MODEL1310110061#
modifier: MODEL1310110061#
is version of: http://identifiers.org/ec-code/6.3.4.2
is described by: ECO:0000254
type: Reaction
reversible: false
is: SBO:0000176
notes: GENE_ASSOCIATION: (1503.1) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 2 AUTHORS: NOTES:
fast: false
reactant: MODEL1310110061#
name: CTP synthase (NH3)

http://identifiers.org/biomodels.db/MODEL1310110061#_53ddf883_c9f0_4dcf_acee_753f9763c810
initial amount: NaN
boundary condition: true
type: Species
is: Q9H0N5
initial concentration: NaN
name: PCBD2
has only substance units: false
is encoded by: hsa:84105
constant: false
is: SBO:0000252

metaM sql r
boundary condition: false
constant: false
is: SBO:0000247
initial concentration: 1.0
is: HMDB00256
notes: FORMULA: C30H50 CHARGE: 0 INCHI: InChI=1S/C30H50/c1-25(2)15-11-19-29(7)23-13-21-27(5)17-9-10-18-28(6)22-14-24-30(8)20-12-16-26(3)4/h15-18,23-24H,9-14,19-22H2,1-8H3/b27-17+,28-18+,29-23+,30-24+ HEPATONET_1.0_ABBREVIATION: HC00526 EHMN_ABBREVIATION: C00751
type: Species
is: CHEBI:15440
has only substance units: false
name: squalene
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110061#_56751162_6e6b_4e8c_86d8_11c21b988838
is: SBO:0000252
is: O60312
initial concentration: NaN
initial amount: NaN
type: Species
boundary condition: true
name: ATP10A
has only substance units: false
constant: false
is encoded by: hsa:57194

metaR r0434
reversible: true
modifier: MODEL1310110061#
reactant: MODEL1310110061#
kinetic law: MODEL1310110061#
notes: GENE_ASSOCIATION: (AI824319.1) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.21 Confidence Level: 0 AUTHORS: PMID:1735445,PMID:1988962,PMID:2355017,PMID:6361812,PMID:7892212 NOTES:
product: MODEL1310110061#
is: SBO:0000176
name: Palmitoyl-CoA:L-carnitine O-palmitoyltransferase Fatty acid metabolism EC:2.3.1.21
is described by: ECO:0000000
fast: false
type: Reaction

metaR r1690
type: Reaction
modifier: MODEL1310110061#
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is described by: ECO:0000000
reactant: MODEL1310110061#
fast: false
reversible: false
product: MODEL1310110061#
kinetic law: MODEL1310110061#
is: SBO:0000185
name: Y+LAT2 Utilized transport

metaM ser L c
initial concentration: 1.0
is: SBO:0000247
constant: false
is: CHEBI:17115
type: Species
has only substance units: false
is: HMDB00187
boundary condition: false
notes: FORMULA: C3H7NO3 CHARGE: 0 INCHI: InChI=1S/C3H7NO3/c4-2(1-5)3(6)7/h2,5H,1,4H2,(H,6,7)/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00068
initial amount: NaN
name: L-serine

metaR LTC4CP
kinetic law: MODEL1310110061#
reactant: MODEL1310110061#
name: Leukotriene C4 carboxypeptidase
reversible: true
product: MODEL1310110061#
notes: GENE_ASSOCIATION: SUBSYSTEM: Eicosanoid metabolism EC Number: 2.3.2.2 Confidence Level: 2 AUTHORS: PMID:12729612 NOTES:Converts leukotriene C4 (LTC4) to leukotriene F4 (LTF4). NJ
type: Reaction
is: SBO:0000176
fast: false
is described by: ECO:0000000

metaM HC02172 c
notes: FORMULA: Zn CHARGE: 2 INCHI: InChI=1S/Zn/q+2
boundary condition: false
has only substance units: false
name: Zinc
initial amount: NaN
constant: false
is: CHEBI:29105
is: SBO:0000247
initial concentration: 1.0
type: Species

metaM HC00342 c
initial concentration: 1.0
is: SBO:0000247
has only substance units: false
initial amount: NaN
type: Species
notes: FORMULA: C6H3O6 CHARGE: -3 INCHI: InChI=1S/C6H6O6/c7-4(8)1-3(6(11)12)2-5(9)10/h1H,2H2,(H,7,8)(H,9,10)(H,11,12)/p-3/b3-1- EHMN_ABBREVIATION: C00417
is: CHEBI:16383
name: cis-aconitate(3-)
boundary condition: false
constant: false

metaR AICART
fast: false
reactant: MODEL1310110061#
is: SBO:0000176
notes: GENE_ASSOCIATION: (471.1) SUBSYSTEM: Purine synthesis EC Number: 2.1.2.3 Confidence Level: 4 AUTHORS: PMID:11948179,PMID:14966129,PMID:9378707 NOTES:
product: MODEL1310110061#
modifier: MODEL1310110061#
reversible: true
is described by: ECO:0000269
kinetic law: MODEL1310110061#
is version of: http://identifiers.org/ec-code/2.1.2.3
type: Reaction
name: phosphoribosylaminoimidazolecarboxamide formyltransferase

metaR THRGLYexR
modifier: MODEL1310110061#
notes: GENE_ASSOCIATION: (56301.1) and (6520.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10734121,PMID:10863037,PMID:14770310 NOTES:
fast: false
product: MODEL1310110061#
is described by: ECO:0000304
is: SBO:0000185
name: L-threonine/glycine reversible exchange
reversible: true
kinetic law: MODEL1310110061#
reactant: MODEL1310110061#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110061#_171ddecf_219b_46bd_90ca_654346fab90b
is: Q9H6R3
is: SBO:0000252
name: ACSS3
initial amount: NaN
has only substance units: false
is encoded by: hsa:79611
initial concentration: NaN
boundary condition: true
constant: false
type: Species

metaR r1051
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:10772724,PMID:12856181 NOTES:
name: Vesicular transport
is: SBO:0000185
reactant: MODEL1310110061#
type: Reaction
fast: false
reversible: true
product: MODEL1310110061#
kinetic law: MODEL1310110061#
is described by: ECO:0000000

metaM adrn e
is: SBO:0000247
has only substance units: false
initial concentration: 1.0
notes: FORMULA: C22H35O2 CHARGE: -1 INCHI: InChI=1S/C22H36O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22(23)24/h6-7,9-10,12-13,15-16H,2-5,8,11,14,17-21H2,1H3,(H,23,24)/b7-6-,10-9-,13-12-,16-15-
constant: false
initial amount: NaN
is: HMDB02226
is: CHEBI:53487
type: Species
name: adrenic acid
boundary condition: false

metaM chol n
notes: FORMULA: C5H14NO CHARGE: 1 INCHI: InChI=1S/C5H14NO/c1-6(2,3)4-5-7/h7H,4-5H2,1-3H3/q+1 HEPATONET_1.0_ABBREVIATION: HC00112 EHMN_ABBREVIATION: C00114
constant: false
boundary condition: false
is: HMDB00097
initial concentration: 1.0
is: CHEBI:15354
has only substance units: false
type: Species
is: SBO:0000247
initial amount: NaN
name: choline

http://identifiers.org/biomodels.db/MODEL1310110061#_c1575f2c_6d01_49e3_964a_dcdbae64bceb
boundary condition: true
is: SBO:0000252
type: Species
initial concentration: NaN
constant: false
has only substance units: false
name: SLC6A10P
is encoded by: hsa:386757
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110061#_7bc4dcc6_4a67_4109_bc4e_deee688c047b
initial concentration: NaN
name: SLC34A2
is encoded by: hsa:10568
constant: false
boundary condition: true
is: O95436
initial amount: NaN
type: Species
has only substance units: false
is: SBO:0000252

metaR GUAPRT
type: Reaction
is: SBO:0000176
notes: GENE_ASSOCIATION: (3251.1) SUBSYSTEM: Nucleotide salvage pathway EC Number: 2.4.2.8 Confidence Level: 4 AUTHORS: PMID:3008106,PMID:6853490 NOTES:Guanine and 6-mercaptopurine can replace hypoxanthine EC added (2.4.2.7 makes the same reaction) IT
reactant: MODEL1310110061#
reversible: false
product: MODEL1310110061#
name: guanine phosphoribosyltransferase
is described by: ECO:0000269
modifier: MODEL1310110061#
kinetic law: MODEL1310110061#
is version of: http://identifiers.org/ec-code/2.4.2.8
fast: false

metaM 5hoxindoa c
name: 5-Hydroxyindoleacetate
constant: false
boundary condition: false
is: SBO:0000247
is: HMDB00763
is: CHEBI:27823
initial amount: NaN
type: Species
has only substance units: false
notes: FORMULA: C10H8NO3 CHARGE: -1 INCHI: InChI=1S/C10H9NO3/c12-7-1-2-9-8(4-7)6(5-11-9)3-10(13)14/h1-2,4-5,11-12H,3H2,(H,13,14) HEPATONET_1.0_ABBREVIATION: HC01537 EHMN_ABBREVIATION: C05635
initial concentration: 1.0

metaM crm hs e
name: N-acylsphingosine
is: CHEBI:52639
initial amount: NaN
notes: FORMULA: C18H36NO2FULLRCO CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC01990 EHMN_ABBREVIATION: C00195
has only substance units: false
type: Species
is: SBO:0000247
constant: false
initial concentration: 1.0
boundary condition: false

metaR P450SCC1m
is described by: ECO:0000134
reactant: MODEL1310110061#
is: SBO:0000176
fast: false
type: Reaction
reversible: true
kinetic law: MODEL1310110061#
name: cholesterol monooxygenase
notes: GENE_ASSOCIATION: SUBSYSTEM: Cholesterol metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:1525048 NOTES:Acting on paired donors with incorporation of molecular oxygen With a reduced iron-sulfur protein as one donor, and incorporation of one atom of oxygen
product: MODEL1310110061#

metaM dgtp n
boundary condition: false
name: dGTP
initial concentration: 1.0
is: HMDB01440
is: C00286
type: Species
is: SBO:0000247
is: CHEBI:16497
constant: false
notes: FORMULA: C10H12N5O13P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00252 EHMN_ABBREVIATION: C00286
has only substance units: false
initial amount: NaN

metaR PRISTCOAtx
is: SBO:0000185
product: MODEL1310110061#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 0 AUTHORS: NOTES:Mechanism not known, see PMID 11591435 for justification. NJ
name: pristcoa peroxisomal transport
kinetic law: MODEL1310110061#
reactant: MODEL1310110061#
type: Reaction
is described by: ECO:0000000
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110061#_8df4e395_fe44_412a_8853_d2435e98e25e
is: P14618
is: SBO:0000252
is encoded by: hsa:5315
boundary condition: true
constant: false
initial concentration: NaN
type: Species
initial amount: NaN
name: PKM2
has only substance units: false

metaM HC01522 c
is: CHEBI:28508
initial amount: NaN
boundary condition: false
notes: FORMULA: C7H6O3 CHARGE: 0 INCHI: InChI=1S/C7H6O3/c8-4-5-3-6(9)1-2-7(5)10/h1-4,9-10H EHMN_ABBREVIATION: C05585
constant: false
name: Gentisate aldehyde
is: SBO:0000247
type: Species
has only substance units: false
initial concentration: 1.0

metaM thcholstoic m
type: Species
is: SBO:0000247
has only substance units: false
constant: false
is: HMDB03873
initial amount: NaN
name: 3alpha,7alpha,12alpha-Trihydroxy-5beta-cholestanoate
notes: FORMULA: C27H45O5 CHARGE: -1 INCHI: InChI=1S/C27H46O5/c1-15(6-5-7-16(2)25(31)32)19-8-9-20-24-21(14-23(30)27(19,20)4)26(3)11-10-18(28)12-17(26)13-22(24)29/h15-24,28-30H,5-14H2,1-4H3,(H,31,32)/t15-,16?,17+,18-,19-,20+,21+,22-,23+,24+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01340 EHMN_ABBREVIATION: C04722
initial concentration: 1.0
is: CHEBI:18402
boundary condition: false

metaM pi g
is: CHEBI:43474
boundary condition: false
is: HMDB00973
name: hydrogenphosphate
has only substance units: false
type: Species
initial concentration: 1.0
constant: false
is: SBO:0000247
initial amount: NaN
notes: FORMULA: HO4P CHARGE: -2 INCHI: InChI=1S/H3O4P/c1-5(2,3)4/h(H3,1,2,3,4)/p-2 HEPATONET_1.0_ABBREVIATION: HC00019 EHMN_ABBREVIATION: C00009

metaR LNSTLSr
reactant: MODEL1310110061#
is version of: http://identifiers.org/ec-code/5.4.99.7
type: Reaction
name: lanosterol synthase
notes: GENE_ASSOCIATION: (4047.1) SUBSYSTEM: Cholesterol metabolism EC Number: 5.4.99.7 Confidence Level: 2 AUTHORS: PMID:17925399,PMID:17925400,PMID:18830876,PMID:18830877 NOTES:NCD ER version - NJ
product: MODEL1310110061#
reversible: false
is: SBO:0000176
kinetic law: MODEL1310110061#
is described by: ECO:0000134
fast: false
modifier: MODEL1310110061#

metaM cl e
is: SBO:0000247
is: CHEBI:3966
constant: false
is: HMDB00492
initial concentration: 1.0
has only substance units: false
initial amount: NaN
is: C00115
notes: FORMULA: Cl CHARGE: -1
name: Chloride
boundary condition: false
type: Species

metaM ile L e
notes: FORMULA: C6H13NO2 CHARGE: 0 INCHI: InChI=1S/C6H13NO2/c1-3-4(2)5(7)6(8)9/h4-5H,3,7H2,1-2H3,(H,8,9)/t4-,5-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00334 EHMN_ABBREVIATION: C00407
boundary condition: false
is: HMDB00172
initial concentration: 1.0
initial amount: NaN
name: L-isoleucine
is: CHEBI:17191
has only substance units: false
is: SBO:0000247
constant: false
type: Species

metaR DM ethamp r
kinetic law: MODEL1310110061#
reactant: MODEL1310110061#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 0 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: false
name: Ethanolamine phosphate demand
type: Reaction

metaM h n
notes: FORMULA: H CHARGE: 1 INCHI: InChI=1S/p+1/i/hH HEPATONET_1.0_ABBREVIATION: HC00083 EHMN_ABBREVIATION: C00080
boundary condition: false
initial concentration: 1.0
has only substance units: false
is: CHEBI:24636
constant: false
initial amount: NaN
name: proton
is: SBO:0000247
type: Species

metaM his L m
constant: false
is: HMDB00177
name: L-histidine
has only substance units: false
type: Species
initial amount: NaN
is: SBO:0000247
initial concentration: 1.0
boundary condition: false
is: CHEBI:15971
notes: FORMULA: C6H9N3O2 CHARGE: 0 INCHI: InChI=1S/C6H9N3O2/c7-5(6(10)11)1-4-2-8-3-9-4/h2-3,5H,1,7H2,(H,8,9)(H,10,11)/t5-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00133

http://identifiers.org/biomodels.db/MODEL1310110061#_3a1238c2_9549_49d6_be64_55aa73a05bc3
initial amount: NaN
initial concentration: NaN
is: SBO:0000252
constant: false
is encoded by: hsa:22978
type: Species
has only substance units: false
boundary condition: true
name: NT5C2
is: P49902

metaM CE5236 c
initial concentration: 1.0
is: SBO:0000247
initial amount: NaN
boundary condition: false
type: Species
is: HMDB03952
constant: false
notes: FORMULA: C9H13N5O3 CHARGE: 0 INCHI: InChI=1/C9H13N5O3/c1-3-5(15)4-2-11-6-9(14-4,17-3)7(16)13-8(10)12-6/h3-5,14-15H,2H2,1H3,(H3,10,11,12,13,16)/p+1/t3-,4u,5+,9u/m0/s1 EHMN_ABBREVIATION: CE5236
name: O2'-4a-cyclic-tetrahydrobiopterin
is: CHEBI:28002
has only substance units: false

metaM hco3 m
initial amount: NaN
is: CHEBI:17544
has only substance units: false
is: HMDB00595
name: Bicarbonate
is: SBO:0000247
is: C00288
initial concentration: 1.0
notes: FORMULA: CHO3 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00253 EHMN_ABBREVIATION: C00288
constant: false
type: Species
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110061#_1fad781e_f40e_4bc4_84fa_1e1b8b2176d8
initial concentration: NaN
is: SBO:0000252
has only substance units: false
type: Species
boundary condition: true
is encoded by: hsa:123041
constant: false
initial amount: NaN
name: SLC24A4

http://identifiers.org/biomodels.db/MODEL1310110061#_b2e2e221_cbfe_4f6f_b780_822fa1668ea5
initial concentration: NaN
is: SBO:0000252
type: Species
name: SDHB
is: P21912
has only substance units: false
is encoded by: hsa:6390
constant: false
initial amount: NaN
boundary condition: true

metaR MTHFD
reactant: MODEL1310110061#
is: SBO:0000176
reversible: true
modifier: MODEL1310110061#
kinetic law: MODEL1310110061#
type: Reaction
product: MODEL1310110061#
name: methylenetetrahydrofolate dehydrogenase (NADP)
is version of: http://identifiers.org/ec-code/1.5.1.5
notes: GENE_ASSOCIATION: (4522.1) SUBSYSTEM: Folate metabolism EC Number: 1.5.1.5 Confidence Level: 4 AUTHORS: PMID:2786332 NOTES:Human Y/N: Y
is described by: ECO:0000134
fast: false

metaM hdca l
initial concentration: 1.0
is: CHEBI:7896
is: SBO:0000247
initial amount: NaN
has only substance units: false
constant: false
notes: FORMULA: C16H31O2 CHARGE: -1 INCHI: InChI=1S/C16H32O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16(17)18/h2-15H2,1H3,(H,17,18)/p-1 HEPATONET_1.0_ABBREVIATION: HC00226 EHMN_ABBREVIATION: C00249
is: HMDB00220
type: Species
boundary condition: false
name: palmitate

metaR PPAn
notes: GENE_ASSOCIATION: SUBSYSTEM: Miscellaneous EC Number: 3.6.1.1 Confidence Level: 1 AUTHORS: NOTES:
kinetic law: MODEL1310110061#
fast: false
type: Reaction
reactant: MODEL1310110061#
name: inorganic diphosphatase, nuclear
reversible: false
is: SBO:0000176
is described by: ECO:0000000
product: MODEL1310110061#

metaM retinol cis 11 c
is: SBO:0000247
has only substance units: false
type: Species
boundary condition: false
constant: false
is: CHEBI:16302
is: HMDB06216
initial amount: NaN
notes: FORMULA: C20H30O CHARGE: 0 INCHI: InChI=1S/C20H30O/c1-16(8-6-9-17(2)13-15-21)11-12-19-18(3)10-7-14-20(19,4)5/h6,8-9,11-13,21H,7,10,14-15H2,1-5H3/b9-6-,12-11+,16-8+,17-13+
name: 11-cis-retinol
initial concentration: 1.0

metaM h m
boundary condition: false
initial concentration: 1.0
is: C00080
name: proton
is: CHEBI:24636
constant: false
initial amount: NaN
is: SBO:0000247
is: http://identifiers.org/pubchem.compound/3380
has only substance units: false
notes: FORMULA: H CHARGE: 1 INCHI: " HEPATONET_1.0_ABBREVIATION: HC00083 EHMN_ABBREVIATION: C00080
type: Species

http://identifiers.org/biomodels.db/MODEL1310110061#_204a0acb_91c2_47bc_b31c_7eb513cf5de8
type: Species
initial amount: NaN
constant: false
initial concentration: NaN
boundary condition: true
is encoded by: hsa:117247
name: SLC16A10
is: Q8TF71
is: SBO:0000252
has only substance units: false

metaR MDHm
kinetic law: MODEL1310110061#
fast: false
is version of: http://identifiers.org/ec-code/1.1.1.37
notes: GENE_ASSOCIATION: (4191.1) SUBSYSTEM: Citric acid cycle EC Number: 1.1.1.37 Confidence Level: 0 AUTHORS: PMID:15565635,PMID:9933076 NOTES:IF. Biochemical
is: SBO:0000176
product: MODEL1310110061#
modifier: MODEL1310110061#
type: Reaction
reversible: true
reactant: MODEL1310110061#
name: malate dehydrogenase, mitochondrial
is described by: ECO:0000134

metaM alpam m
constant: false
initial concentration: 1.0
name: S-aminomethyldihydrolipoamide
initial amount: NaN
type: Species
notes: FORMULA: C9H21N2OS2 CHARGE: 1 INCHI: InChI=1/C9H20N2OS2/c10-7-14-6-5-8(13)3-1-2-4-9(11)12/h8,13H,1-7,10H2,(H2,11,12)
is: HMDB06239
has only substance units: false
boundary condition: false
is: SBO:0000247

metaM nadh c
has only substance units: false
initial concentration: 1.0
is: http://identifiers.org/pubchem.compound/3306
is: HMDB01487
boundary condition: false
initial amount: NaN
is: C00004
constant: false
name: Nicotinamide adenine dinucleotide - reduced
type: Species
is: SBO:0000247
is: CHEBI:57945

http://identifiers.org/biomodels.db/MODEL1310110061#_56e43247_9144_478b_a964_ee9d73eb474e
boundary condition: true
initial amount: NaN
is: O00217
type: Species
initial concentration: NaN
constant: false
has only substance units: false
is: SBO:0000252
name: NDUFS8
is encoded by: hsa:4728

http://identifiers.org/biomodels.db/MODEL1310110061#_1b26b11e_dd4b_4950_8d5e_6e49227b1f39
initial amount: NaN
name: LHPP
type: Species
initial concentration: NaN
constant: false
is encoded by: hsa:64077
is: SBO:0000252
boundary condition: true
is: Q9H008
has only substance units: false

metaR r0758
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/3.5.4.16
name: 5-Hydroxyindoleacetaldehyde:NAD+ oxidoreductase Tryptophan metabolism EC:1.2.1.3
kinetic law: MODEL1310110061#
reactant: MODEL1310110061#
notes: GENE_ASSOCIATION: (2643.1) SUBSYSTEM: Tryptophan metabolism EC Number: 1.2.1.3 Confidence Level: 0 AUTHORS: PMID:8155713,PMID:8605195 NOTES:
type: Reaction
reversible: true
fast: false
product: MODEL1310110061#
modifier: MODEL1310110061#
is: SBO:0000176

metaM ser L e
type: Species
constant: false
name: L-serine
is: SBO:0000247
is: CHEBI:17115
initial concentration: 1.0
has only substance units: false
is: HMDB00187
initial amount: NaN
notes: FORMULA: C3H7NO3 CHARGE: 0 INCHI: InChI=1S/C3H7NO3/c4-2(1-5)3(6)7/h2,5H,1,4H2,(H,6,7)/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00068
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110061#_34c668ac_3942_4eb0_8845_638c4ab28c15
boundary condition: true
constant: false
is: P00338
initial concentration: NaN
is encoded by: hsa:3939
has only substance units: false
type: Species
initial amount: NaN
name: LDHA
is: SBO:0000252

metaR EX met L LPAREN e RPAREN
kinetic law: MODEL1310110061#
reactant: MODEL1310110061#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: L-Methionine exchange
type: Reaction

metaR PROSTGF2t
kinetic law: MODEL1310110061#
reactant: MODEL1310110061#
reversible: true
is described by: ECO:0000269
product: MODEL1310110061#
type: Reaction
is: SBO:0000185
fast: false
modifier: MODEL1310110061#
name: prostaglandin uniport
notes: GENE_ASSOCIATION: (6582.2) or (6582.1) or (6580.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12827517,PMID:12883891,PMID:9187257 NOTES:electrogenic, Na indepdendent & rev NJ

http://identifiers.org/biomodels.db/MODEL1310110061#_f84e072e_fcf3_4797_b21f_b1cd4cd43199
boundary condition: true
is encoded by: hsa:642502
constant: false
is: SBO:0000252
type: Species
initial amount: NaN
initial concentration: NaN
name: _642502_1_c
has only substance units: false

metaR TXASr
name: Thromboxane-A synthase
reactant: MODEL1310110061#
is version of: http://identifiers.org/ec-code/5.3.99.5
notes: GENE_ASSOCIATION: (6916.1) SUBSYSTEM: Eicosanoid metabolism EC Number: 5.3.99.5 Confidence Level: 0 AUTHORS: PMID:10903770,PMID:2491846,PMID:7811713 NOTES:NJ
is: SBO:0000176
modifier: MODEL1310110061#
reversible: false
type: Reaction
is described by: ECO:0000134
fast: false
kinetic law: MODEL1310110061#
product: MODEL1310110061#

metaR EX citr L LPAREN e RPAREN
kinetic law: MODEL1310110061#
reactant: MODEL1310110061#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: L-citrulline exchange
type: Reaction

metaM pmtcrn r
initial amount: NaN
is: CHEBI:17490
initial concentration: 1.0
is: HMDB00222
has only substance units: false
boundary condition: false
type: Species
name: L-palmitoylcarnitine
is: SBO:0000247
constant: false
notes: FORMULA: C23H45NO4 CHARGE: 0 INCHI: InChI=1S/C23H45NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-23(27)28-21(19-22(25)26)20-24(2,3)4/h21H,5-20H2,1-4H3/t21-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01034 EHMN_ABBREVIATION: C02990

http://identifiers.org/biomodels.db/MODEL1310110061#_76dc764e_77bb_4761_a9fc_af58ff627419
name: SLC23A2
is: SBO:0000252
boundary condition: true
initial concentration: NaN
constant: false
is encoded by: hsa:9962
is: Q9UGH3
initial amount: NaN
type: Species
has only substance units: false

metaR r0437
fast: false
type: Reaction
reversible: true
is version of: http://identifiers.org/ec-code/4.1.2.13
reactant: MODEL1310110061#
modifier: MODEL1310110061#
name: Palmitoyl-CoA:L-carnitine O-palmitoyltransferase Fatty acid metabolism EC:2.3.1.21
product: MODEL1310110061#
is: SBO:0000176
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (AI469183.1) or (226.1) or (229.1) or (230.1) or (BC005314.1) or (BF195998.1) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.21 Confidence Level: 0 AUTHORS: PMID:1735445,PMID:1988962,PMID:2355017,PMID:6361812,PMID:7892212 NOTES:
kinetic law: MODEL1310110061#

metaM eitetcoa m
constant: false
initial concentration: 1.0
type: Species
name: 5,8,11,14-eicosatetraenoylcoa
initial amount: NaN
notes: FORMULA: C41H62N7O17P3S CHARGE: -4
is: SBO:0000247
is: HMDB02288
boundary condition: false
has only substance units: false

metaR CHSTEROLt1
notes: GENE_ASSOCIATION: (10948.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: PMID:12070139,PMID:12370263,PMID:12770731 NOTES:specific mechanism not known, proton dependence for trans-mit transport has been suggested, however directionality and stoichiometry has not yet been elucidated. see PMID: 12770731 and others NJ. NS: transport from lysozyme to mitochondria?
modifier: MODEL1310110061#
fast: false
reactant: MODEL1310110061#
product: MODEL1310110061#
type: Reaction
reversible: true
is: SBO:0000185
kinetic law: MODEL1310110061#
is described by: ECO:0000304
name: cholesterol intracellular transport

metaR H2Ot
is described by: ECO:0000269
is: SBO:0000185
type: Reaction
fast: false
name: H2O transport via diffusion
modifier: MODEL1310110061#
notes: GENE_ASSOCIATION: (6523.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:11024018,PMID:11034615,PMID:12748858,PMID:2490366,PMID:8063771 NOTES:renamed from H20t5 to H2Ot NCD
kinetic law: MODEL1310110061#
product: MODEL1310110061#
reactant: MODEL1310110061#
reversible: true

metaM lys L m
initial concentration: 1.0
is: CHEBI:32551
type: Species
constant: false
initial amount: NaN
is: HMDB00182
name: L-lysinium(1+)
boundary condition: false
is: SBO:0000247
has only substance units: false
notes: FORMULA: C6H15N2O2 CHARGE: 1 INCHI: InChI=1S/C6H14N2O2/c7-4-2-1-3-5(8)6(9)10/h5H,1-4,7-8H2,(H,9,10)/p+1/t5-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00053 EHMN_ABBREVIATION: C00047

metaM h l
type: Species
notes: FORMULA: H CHARGE: 1 INCHI: "
is: http://identifiers.org/pubchem.compound/3380
name: proton
is: CHEBI:24636
constant: false
initial amount: NaN
is: SBO:0000247
boundary condition: false
initial concentration: 1.0
is: C00080
has only substance units: false

metaR r1050
is: SBO:0000185
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:10772724,PMID:12856181 NOTES:
type: Reaction
reactant: MODEL1310110061#
product: MODEL1310110061#
name: Vesicular transport
reversible: true
is described by: ECO:0000000
kinetic law: MODEL1310110061#

metaR EX pyr LPAREN e RPAREN
kinetic law: MODEL1310110061#
reactant: MODEL1310110061#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Pyruvate exchange
type: Reaction

metaM pail4p hs c
notes: FORMULA: C9H15O12P2FULLRCO2FULLR2CO2 CHARGE: -3 EHMN_ABBREVIATION: C01277
has only substance units: false
is: CHEBI:58178
type: Species
boundary condition: false
initial concentration: 1.0
constant: false
is: SBO:0000247
name: 1-phosphatidyl-1D-myo-inositol 4-phosphate(3-)
initial amount: NaN

metaR Q10H2e
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 3 AUTHORS: PMID: 17482886. NOTES:plasma concentration of ubiquinol indicates healthy state of an individual.
product: MODEL1310110061#
name: transport of ubiquinol into lymph
is: SBO:0000185
is described by: ECO:0000134
reactant: MODEL1310110061#
kinetic law: MODEL1310110061#
reversible: true
fast: false

metaR C4STMO2Pr
kinetic law: MODEL1310110061#
fast: false
name: C-4 methyl sterol oxidase
reactant: MODEL1310110061#
modifier: MODEL1310110061#
product: MODEL1310110061#
is: SBO:0000176
type: Reaction
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (50814.1) SUBSYSTEM: Cholesterol metabolism EC Number: Confidence Level: 4 AUTHORS: NOTES:double check rxn specifics - see lit ref: Marijanovic, Molecular Endocrinology 2003 17:1715-1725 ER version NJ
reversible: false
is version of: http://identifiers.org/ec-code/1.1.1.170

metaR COAtr
reversible: true
kinetic law: MODEL1310110061#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: NOTES:diffusion NJ
type: Reaction
fast: false
name: COA transporter, endoplasmic reticulum
is: SBO:0000185
reactant: MODEL1310110061#
is described by: ECO:0000000
product: MODEL1310110061#

metaM h2o2 m
constant: false
is: SBO:0000247
name: Hydrogen peroxide
boundary condition: false
initial amount: NaN
type: Species
is: HMDB03125
is: C00027
initial concentration: 1.0
has only substance units: false
is: CHEBI:16240
notes: FORMULA: H2O2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00036 EHMN_ABBREVIATION: C00027

metaR C226CRNt
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: PMID:14598172 NOTES:TDV
product: MODEL1310110061#
reversible: false
kinetic law: MODEL1310110061#
is: SBO:0000185
is described by: ECO:0000000
fast: false
name: C226 transport into the mitochondria
type: Reaction
reactant: MODEL1310110061#

metaR PGLYCt
is: SBO:0000185
name: phosphatidylglycerol transport
type: Reaction
reactant: MODEL1310110061#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: 3.1.3.18 Confidence Level: 2 AUTHORS: PMID:2164460,PMID:6290284 NOTES:
product: MODEL1310110061#
reversible: true
kinetic law: MODEL1310110061#
is described by: ECO:0000269
fast: false

metaR PPAt
reversible: false
fast: false
name: Propionate transport, diffusion
kinetic law: MODEL1310110061#
product: MODEL1310110061#
reactant: MODEL1310110061#
is: SBO:0000185
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:8135845 NOTES:TDV
type: Reaction

metaR r0647
reversible: true
type: Reaction
product: MODEL1310110061#
fast: false
name: Spontaneous reaction
is: SBO:0000176
kinetic law: MODEL1310110061#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Tryptophan metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:18124509,PMID:6027578 NOTES:
reactant: MODEL1310110061#

http://identifiers.org/biomodels.db/MODEL1310110061#_06677b8b_f912_4995_8ce6_f4671537c8c6
boundary condition: true
constant: false
is encoded by: hsa:5373
is: SBO:0000252
name: PMM2
type: Species
has only substance units: false
initial amount: NaN
initial concentration: NaN
is: O15305

metaR 3AIB Dtm
product: MODEL1310110061#
is: SBO:0000185
reactant: MODEL1310110061#
reversible: true
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 1 AUTHORS: no transporter could be identified, so diffusion is assumed. NOTES:
name: transport of 3aib_D into mitochondria
is described by: ECO:0000134
fast: false
kinetic law: MODEL1310110061#

http://identifiers.org/biomodels.db/MODEL1310110061#_c7c93065_997f_47ff_a99a_2cc5e656079f
is encoded by: hsa:3284
has only substance units: false
name: HSD3B2
constant: false
boundary condition: true
initial amount: NaN
is: P26439
is: SBO:0000252
type: Species
initial concentration: NaN

metaM 2docohexecoa m
boundary condition: false
is: HMDB02288
has only substance units: false
initial concentration: 1.0
initial amount: NaN
name: 2,7,10,13,16,19-docosahexenoylcoa
type: Species
is: SBO:0000247
notes: FORMULA: C43H62N7O17P3S CHARGE: -4
constant: false

metaR r0165
fast: false
kinetic law: MODEL1310110061#
modifier: MODEL1310110061#
product: MODEL1310110061#
reactant: MODEL1310110061#
type: Reaction
reversible: false
notes: GENE_ASSOCIATION: (6576.1) SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: 2.7.1.40 Confidence Level: 0 AUTHORS: PMID:1009117,PMID:7154942 NOTES:
is described by: ECO:0000000
is: SBO:0000176
name: UTP:pyruvate O2-phosphotransferase EC:2.7.1.40

metaR ACNAMtn
type: Reaction
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD
is described by: ECO:0000000
reactant: MODEL1310110061#
is: SBO:0000185
reversible: false
name: N-acetylneuraminate nuclear import
kinetic law: MODEL1310110061#
product: MODEL1310110061#

metaR EX CE5786 LPAREN e RPAREN
kinetic law: MODEL1310110061#
reactant: MODEL1310110061#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: kinetensin exchange
type: Reaction

metaM ile L c
is: CHEBI:17191
has only substance units: false
notes: FORMULA: C6H13NO2 CHARGE: 0 INCHI: InChI=1S/C6H13NO2/c1-3-4(2)5(7)6(8)9/h4-5H,3,7H2,1-2H3,(H,8,9)/t4-,5-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00334 EHMN_ABBREVIATION: C00407
is: SBO:0000247
initial amount: NaN
is: HMDB00172
boundary condition: false
constant: false
type: Species
initial concentration: 1.0
name: L-isoleucine

metaM gln L m
name: L-glutamine
constant: false
notes: FORMULA: C5H10N2O3 CHARGE: 0 INCHI: InChI=1S/C5H10N2O3/c6-3(5(9)10)1-2-4(7)8/h3H,1-2,6H2,(H2,7,8)(H,9,10)/t3-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00067
is: CHEBI:18050
boundary condition: false
initial concentration: 1.0
type: Species
has only substance units: false
is: HMDB00641
initial amount: NaN
is: SBO:0000247

metaR CHSTEROLt2
kinetic law: MODEL1310110061#
product: MODEL1310110061#
fast: false
reactant: MODEL1310110061#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: PMID:12370263,PMID:12770731 NOTES:specific mechanism not known, proton dependence for trans-mit transport has been suggested, however directionality and stoichiometry has not yet been elucidated. see PMID: 12770731 and others NJ
is: SBO:0000185
reversible: true
type: Reaction
name: cholesterol intracellular transport
is described by: ECO:0000000

metaR MI3PP
reactant: MODEL1310110061#
is: SBO:0000176
fast: false
notes: GENE_ASSOCIATION: (3612.1) or (3613.1) SUBSYSTEM: Inositol phosphate metabolism EC Number: 3.1.3.25 Confidence Level: 4 AUTHORS: PMID:1377913,PMID:2906139,PMID:9322233 NOTES:NCD
is version of: http://identifiers.org/ec-code/3.1.3.25
modifier: MODEL1310110061#
name: myo-inositol 3-phosphatase
type: Reaction
kinetic law: MODEL1310110061#
product: MODEL1310110061#
is described by: ECO:0000269
reversible: false

metaR UDPACGALtl
is described by: ECO:0000000
fast: false
kinetic law: MODEL1310110061#
product: MODEL1310110061#
name: udpacgal intracellular transport
type: Reaction
is: SBO:0000185
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 1 AUTHORS: NOTES:unknown mechanism for transport - there are UDPACGAL-translocators for ER and Golgi, however no info on lysosomal - poor support for this NJ
reactant: MODEL1310110061#

metaM tchola c
constant: false
is: HMDB00036
initial concentration: 1.0
has only substance units: false
is: SBO:0000247
name: taurocholic acid
type: Species
is: CHEBI:36257
notes: FORMULA: C26H45NO7S CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC01378 EHMN_ABBREVIATION: C05122
initial amount: NaN
boundary condition: false

metaM asp L e
constant: false
notes: FORMULA: C4H6NO4 CHARGE: -1 INCHI: InChI=1S/C4H7NO4/c5-2(4(8)9)1-3(6)7/h2H,1,5H2,(H,6,7)(H,8,9)/p-1/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00055
name: L-aspartate(1-)
initial concentration: 1.0
type: Species
has only substance units: false
is: CHEBI:29991
initial amount: NaN
is: HMDB00191
boundary condition: false
is: SBO:0000247

metaM Sfglutth c
is: HMDB01550
initial amount: NaN
name: S-formylglutathionate(1-)
is: CHEBI:57688
has only substance units: false
constant: false
notes: FORMULA: C11H16N3O7S CHARGE: -1 INCHI: InChI=1S/C11H17N3O7S/c12-6(11(20)21)1-2-8(16)14-7(4-22-5-15)10(19)13-3-9(17)18/h5-7H,1-4,12H2,(H,13,19)(H,14,16)(H,17,18)(H,20,21)/p-1/t6-,7-/m0/s1 EHMN_ABBREVIATION: C01031
is: SBO:0000247
type: Species
boundary condition: false
initial concentration: 1.0

metaM ksii core2 deg8 l
is: SBO:0000247
name: keratan sulfate II (core 2-linked), degradation product 8
initial concentration: 1.0
is: CHEBI:12936
has only substance units: false
notes: FORMULA: C36H60N3O25X CHARGE: 0
boundary condition: false
type: Species
is: HMDB00143
initial amount: NaN
constant: false

metaR D LACt2
kinetic law: MODEL1310110061#
is described by: ECO:0000269
is: SBO:0000185
reactant: MODEL1310110061#
modifier: MODEL1310110061#
reversible: true
name: D-lactate transport via proton symport
type: Reaction
product: MODEL1310110061#
fast: false
notes: GENE_ASSOCIATION: (9194.1) or (23539.1) or (6566.1) or (9123.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10493836,PMID:10510291,PMID:11101640,PMID:12739169,PMID:7835905,PMID:8476015,PMID:9425115,PMID:9508842,PMID:9649795,PMID:9786900,PMID:9824713 NOTES:JLR

metaM C02470 c
initial concentration: 1.0
notes: FORMULA: C10H6NO4 CHARGE: -1 INCHI: InChI=1/C10H7NO4/c12-7-3-1-2-5-8(13)4-6(10(14)15)11-9(5)7/h1-4,12H,(H,11,13)(H,14,15) HEPATONET_1.0_ABBREVIATION: HC00945 EHMN_ABBREVIATION: C02470
is: http://identifiers.org/pubchem.compound/5485
initial amount: NaN
boundary condition: false
is: HMDB00881
type: Species
name: Xanthurenic acid
constant: false
is: C02470
has only substance units: false
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110061#_82341080_9e34_48b0_b941_0041b1bebb73
is encoded by: hsa:3098
name: HK1
has only substance units: false
boundary condition: true
initial amount: NaN
constant: false
is: P19367
type: Species
initial concentration: NaN
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110061#_863c10eb_8739_4c0f_a29d_2564e3cfc852
has part: P08195
type: Species
has part: Q9NS82
is encoded by: hsa:56301
initial concentration: NaN
is: SBO:0000297
initial amount: NaN
is encoded by: hsa:6520
constant: false
boundary condition: true
name: SLC7A10:SLC3A2
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110061#_7227fa94_c322_4859_a001_d62dd28d2dab
has only substance units: false
initial amount: NaN
type: Species
is: P27338
name: MAOB
boundary condition: true
is encoded by: hsa:4129
is: SBO:0000252
constant: false
initial concentration: NaN

metaR EX 10fthf LPAREN e RPAREN
kinetic law: MODEL1310110061#
reactant: MODEL1310110061#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 10-Formyltetrahydrofolate exchange
type: Reaction

metaM itacon m
constant: false
boundary condition: false
notes: FORMULA: C5H4O4 CHARGE: -2 INCHI: InChI=1S/C5H6O4/c1-3(5(8)9)2-4(6)7/h1-2H2,(H,6,7)(H,8,9)/p-2 EHMN_ABBREVIATION: C00490
name: itaconate(2-)
is: CHEBI:17240
initial concentration: 1.0
is: HMDB02092
type: Species
has only substance units: false
is: SBO:0000247
initial amount: NaN

metaR ECOAH12m
reactant: MODEL1310110061#
is version of: http://identifiers.org/ec-code/4.2.1.17
reversible: true
name: 3-hydroxyacyl-CoA dehydratase (3-hydroxyisobutyryl-CoA) (mitochondria)
kinetic law: MODEL1310110061#
fast: false
is version of: http://identifiers.org/ec-code/2.3.1.16
modifier: MODEL1310110061#
notes: GENE_ASSOCIATION: (1892.1) or (3030.1) and (3032.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 4.2.1.17 Confidence Level: 2 AUTHORS: PMID:9073515 NOTES:MM. based on assigned short chain enoyl-CoA hydratase activity
product: MODEL1310110061#
is: SBO:0000176
is described by: ECO:0000304
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110061#_48dae7d0_045d_44a9_998b_033c1df94798
constant: false
boundary condition: true
has only substance units: false
initial concentration: NaN
is: SBO:0000252
is: Q86U05
type: Species
name: SLC7A8
is encoded by: hsa:23428
initial amount: NaN

metaR SERTHRNaEx
reversible: false
product: MODEL1310110061#
is: SBO:0000185
fast: false
is described by: ECO:0000269
kinetic law: MODEL1310110061#
name: L-serine/L-threonine Na-dependent exchange (Ser-L in)
reactant: MODEL1310110061#
type: Reaction
notes: GENE_ASSOCIATION: (6509.1) or (6510.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14530974 NOTES:SAB see Kanai and Hediger 2004 (2003), PMID 14530974
modifier: MODEL1310110061#

metaM mal L m
is: HMDB00156
is: SBO:0000247
constant: false
notes: FORMULA: C4H4O5 CHARGE: -2 INCHI: InChI=1S/C4H6O5/c5-2(4(8)9)1-3(6)7/h2,5H,1H2,(H,6,7)(H,8,9)/p-2/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00146
name: (S)-malate(2-)
boundary condition: false
has only substance units: false
initial amount: NaN
is: CHEBI:15589
type: Species
initial concentration: 1.0

metaR RE3624M
fast: false
product: MODEL1310110061#
type: Reaction
is: SBO:0000176
is described by: ECO:0000000
reactant: MODEL1310110061#
kinetic law: MODEL1310110061#
name: RE3624
modifier: MODEL1310110061#
notes: GENE_ASSOCIATION: (51.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.3.6 Confidence Level: 0 AUTHORS: PMID:11356164,PMID:7775433 NOTES:
is version of: http://identifiers.org/ec-code/1.3.3.6
reversible: false

metaR FAOXC16C14m
kinetic law: MODEL1310110061#
product: MODEL1310110061#
reactant: MODEL1310110061#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C16-->C14)m
type: Reaction

metaR r2202
is: SBO:0000185
modifier: MODEL1310110061#
fast: false
reactant: MODEL1310110061#
kinetic law: MODEL1310110061#
notes: GENE_ASSOCIATION: (6566.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
type: Reaction
is described by: ECO:0000000
product: MODEL1310110061#
reversible: true
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.5

metaR CHSTEROLt3
name: cholesterol intracellular transport
product: MODEL1310110061#
reactant: MODEL1310110061#
reversible: true
type: Reaction
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: PMID:12370263,PMID:12770731 NOTES:specific mechanism not known, proton dependence for trans-mit transport has been suggested, however directionality and stoichiometry has not yet been elucidated. see PMID: 12770731 and others NJ
fast: false
is: SBO:0000185
kinetic law: MODEL1310110061#

metaR r1453
product: MODEL1310110061#
reversible: true
is described by: ECO:0000000
kinetic law: MODEL1310110061#
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: Confidence Level: 0 AUTHORS: PMID:18506409 NOTES:
is: SBO:0000176
fast: false
reactant: MODEL1310110061#
name: L-proline:(acceptor) oxidoreductase Arginine and proline metabolism EC:1.5.99.8
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110061#_a01ceb8e_bd6b_4b4a_aeca_0a564a490c41
constant: false
is: Q9Y345
initial concentration: NaN
has only substance units: false
is: SBO:0000252
type: Species
initial amount: NaN
is encoded by: hsa:9152
name: SLC6A5
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110061#_06f8b7e2_c4f4_4d1e_a1de_f71bdc33f7ad
initial concentration: NaN
is: SBO:0000252
type: Species
is encoded by: hsa:8802
has only substance units: false
name: SUCLG1
is: P53597
constant: false
initial amount: NaN
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110061#_3c9edc0c_fe82_4873_a654_7e326a2a6688
has only substance units: false
boundary condition: true
type: Species
is: SBO:0000252
constant: false
name: _AW299740_1_m
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:AW299740

http://identifiers.org/biomodels.db/MODEL1310110061#_64ed1d0a_684b_4432_8d3e_cabd1a68bbb6
is encoded by: hsa:4645
constant: false
is: SBO:0000252
initial amount: NaN
is: Q9H6Y6
type: Species
boundary condition: true
has only substance units: false
initial concentration: NaN
name: MYO5B

metaR LNLCCRNt
modifier: MODEL1310110061#
fast: false
kinetic law: MODEL1310110061#
product: MODEL1310110061#
name: transport into the mitochondria (carnitine)
is described by: ECO:0000269
type: Reaction
reversible: false
reactant: MODEL1310110061#
is: SBO:0000185
notes: GENE_ASSOCIATION: (788.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: NOTES:NJ

metaR ASNSERNaEx
is: SBO:0000185
notes: GENE_ASSOCIATION: (6510.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14530974 NOTES:SAB see Kanai and Hediger 2004 (2003), PMID 14530974
modifier: MODEL1310110061#
reversible: false
is described by: ECO:0000269
name: L-serine/L-asparagine Na-dependent exchange (Asn-L in)
type: Reaction
reactant: MODEL1310110061#
fast: false
kinetic law: MODEL1310110061#
product: MODEL1310110061#

metaM pi c
initial amount: NaN
boundary condition: false
is: CHEBI:43474
initial concentration: 1.0
name: hydrogenphosphate
notes: FORMULA: HO4P CHARGE: -2
is: SBO:0000247
type: Species
constant: false
has only substance units: false
is: HMDB00973
is: C00009

metaM dmpp x
is: SBO:0000247
boundary condition: false
constant: false
name: prenyl diphosphate(3-)
is: HMDB01120
is: CHEBI:57623
initial amount: NaN
type: Species
initial concentration: 1.0
has only substance units: false
notes: FORMULA: C5H9O7P2 CHARGE: -3 INCHI: InChI=1S/C5H12O7P2/c1-5(2)3-4-11-14(9,10)12-13(6,7)8/h3H,4H2,1-2H3,(H,9,10)(H2,6,7,8)/p-3 HEPATONET_1.0_ABBREVIATION: HC00213 EHMN_ABBREVIATION: C00235

metaM xoldiolone c
is: HMDB02197
notes: FORMULA: C27H44O3 CHARGE: 0 INCHI: InChI=1S/C27H44O3/c1-16(2)7-6-8-17(3)20-9-10-21-25-22(15-24(30)27(20,21)5)26(4)12-11-19(28)13-18(26)14-23(25)29/h13,16-17,20-25,29-30H,6-12,14-15H2,1-5H3/t17-,20-,21+,22+,23-,24+,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01465 EHMN_ABBREVIATION: C05457
name: 7alpha,12alpha-Dihydroxycholest-4-en-3-one
type: Species
has only substance units: false
is: CHEBI:28477
initial concentration: 1.0
constant: false
boundary condition: false
initial amount: NaN
is: SBO:0000247

metaR r1454
type: Reaction
is described by: ECO:0000000
is: SBO:0000185
name: TCDB:2.A.1.13.5 TCDB:2.A.1.13.1
kinetic law: MODEL1310110061#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:17603022,PMID:6240978,PMID:7876265 NOTES:
fast: false
reversible: false
reactant: MODEL1310110061#
product: MODEL1310110061#

metaR CYOOm3
modifier: MODEL1310110061#
reactant: MODEL1310110061#
is: SBO:0000185
name: cytochrome c oxidase, mitochondrial Complex IV
is version of: http://identifiers.org/ec-code/1.9.3.1
fast: false
product: MODEL1310110061#
type: Reaction
notes: GENE_ASSOCIATION: (1351.1) and (1347.1) and (1329.1) and (1327.1) and (341947.1) and (9167.1) and (1350.1) and (4512.1) and (1349.1) and (1339.1) and (1345.1) and (4513.1) and (9377.1) and (125965.1) and (4514.1) and (170712.1) and (1346.1) and (1340.1) and (84701.1) and (1337.1) SUBSYSTEM: Oxidative phosphorylation EC Number: Confidence Level: 4 AUTHORS: PMID:10869362,PMID:12241082 NOTES:TV, 2% O2 lost in O2-
kinetic law: MODEL1310110061#
is described by: ECO:0000134
reversible: false

metaR EX din LPAREN e RPAREN
kinetic law: MODEL1310110061#
reactant: MODEL1310110061#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for Deoxyinosine
type: Reaction

metaM tchola e
initial concentration: 1.0
name: taurocholic acid
constant: false
is: HMDB00036
boundary condition: false
initial amount: NaN
notes: FORMULA: C26H45NO7S CHARGE: 0
is: SBO:0000247
type: Species
has only substance units: false

metaM dcmp c
notes: FORMULA: C9H12N3O7P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00217 EHMN_ABBREVIATION: C00239
type: Species
is: C00239
initial amount: NaN
is: CHEBI:57566
constant: false
initial concentration: 1.0
name: dCMP
boundary condition: false
is: HMDB01202
is: SBO:0000247
has only substance units: false

metaR r2201
kinetic law: MODEL1310110061#
fast: false
reactant: MODEL1310110061#
is: SBO:0000185
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.5
type: Reaction
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (6566.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
modifier: MODEL1310110061#
product: MODEL1310110061#
reversible: true

metaR COAtm
type: Reaction
notes: GENE_ASSOCIATION: (8034.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172 NOTES:TV May not a "real" transporter, use in heart mitochondria model only
kinetic law: MODEL1310110061#
is described by: ECO:0000269
is: SBO:0000185
name: CoA transporter
fast: false
modifier: MODEL1310110061#
product: MODEL1310110061#
reactant: MODEL1310110061#
reversible: true

metaM ddsmsterol r
constant: false
is: HMDB03896
has only substance units: false
boundary condition: false
type: Species
name: 7-dehydrodesmosterol
initial concentration: 1.0
is: CHEBI:27910
initial amount: NaN
is: SBO:0000247
notes: FORMULA: C27H42O CHARGE: 0 INCHI: InChI=1S/C27H42O/c1-18(2)7-6-8-19(3)23-11-12-24-22-10-9-20-17-21(28)13-15-26(20,4)25(22)14-16-27(23,24)5/h7,9-10,19,21,23-25,28H,6,8,11-17H2,1-5H3/t19-,21+,23-,24+,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01373

metaR FACOAL240
is version of: http://identifiers.org/ec-code/6.2.1.3
is: SBO:0000176
reversible: true
type: Reaction
modifier: MODEL1310110061#
product: MODEL1310110061#
is described by: ECO:0000269
reactant: MODEL1310110061#
fast: false
name: fatty-acid--CoA ligase
kinetic law: MODEL1310110061#
notes: GENE_ASSOCIATION: (2180.1) SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 4 AUTHORS: PMID:15292367 NOTES:NJ

metaR EX prostgi2 LPAREN e RPAREN
kinetic law: MODEL1310110061#
reactant: MODEL1310110061#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: prostaglandin I2(1-) exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110061#_ae0ef87d_0764_48fb_8bc1_3c81dfe44449
constant: false
type: Species
boundary condition: true
is encoded by: hsa:51095
name: TRNT1
initial concentration: NaN
is: SBO:0000252
is: Q96Q11
has only substance units: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110061#_33bdf23f_492f_4343_b7fb_72250d64e294
type: Species
boundary condition: true
has only substance units: false
constant: false
is encoded by: hsa:222
initial concentration: NaN
initial amount: NaN
is: P48448
name: ALDH3B2
is: SBO:0000252

metaR EX tag hs LPAREN e RPAREN
kinetic law: MODEL1310110061#
reactant: MODEL1310110061#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: triacylglycerol (homo sapiens) exchange
type: Reaction

metaR RAI1
product: MODEL1310110061#
fast: false
is: SBO:0000176
kinetic law: MODEL1310110061#
notes: GENE_ASSOCIATION: SUBSYSTEM: Vitamin A metabolism EC Number: 5.2.1.3 Confidence Level: 2 AUTHORS: PMID:1503811 NOTES:IT
name: retinal isomerase (11-cis)
reversible: true
type: Reaction
is described by: ECO:0000000
reactant: MODEL1310110061#

metaR r0539
notes: GENE_ASSOCIATION: (3156.1) SUBSYSTEM: Taurine and hypotaurine metabolism EC Number: 1.13.11.19 Confidence Level: 0 AUTHORS: PMID:17153586,PMID:17581819,PMID:3657558 NOTES:
product: MODEL1310110061#
modifier: MODEL1310110061#
name: Cysteamine:oxygen oxidoreductase Taurine and hypotaurine metabolism EC:1.13.11.19
type: Reaction
is version of: http://identifiers.org/ec-code/1.1.1.34
is: SBO:0000176
reversible: true
fast: false
is described by: ECO:0000000
reactant: MODEL1310110061#
kinetic law: MODEL1310110061#

metaR r0381
notes: GENE_ASSOCIATION: SUBSYSTEM: Taurine and hypotaurine metabolism EC Number: 1.8.1.3 Confidence Level: 0 AUTHORS: PMID:13979247,PMID:16680556,PMID:7295801 NOTES:
reversible: true
kinetic law: MODEL1310110061#
name: hypotaurine:NAD+ oxidoreductase Taurine and hypotaurine metabolism EC:1.8.1.3
is described by: ECO:0000000
reactant: MODEL1310110061#
is: SBO:0000176
type: Reaction
fast: false
product: MODEL1310110061#

metaM 3octpencoa m
initial amount: NaN
notes: FORMULA: C39H56N7O17P3S CHARGE: -4
initial concentration: 1.0
name: 3,6,9,12,15-octadecapentenoylcoa
type: Species
constant: false
is: SBO:0000247
is: HMDB02288
has only substance units: false
boundary condition: false

metaR EX dpcoa LPAREN e RPAREN
kinetic law: MODEL1310110061#
reactant: MODEL1310110061#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for dpcoa
type: Reaction

metaR KHte
kinetic law: MODEL1310110061#
name: KHte
fast: false
is: SBO:0000185
product: MODEL1310110061#
is described by: ECO:0000134
type: Reaction
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
reactant: MODEL1310110061#

metaR 34DHXMANDACOX
modifier: MODEL1310110061#
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (221.1) or (218.1) or (220.1) SUBSYSTEM: Tyrosine metabolism EC Number: 1.2.1.5 Confidence Level: 4 AUTHORS: PMID:10424772,PMID:12616643 NOTES:SAB
name: 3,4-Dihydroxymandelaldehyde:NAD+ oxidoreductase
is: SBO:0000176
product: MODEL1310110061#
type: Reaction
reactant: MODEL1310110061#
reversible: false
fast: false
is version of: http://identifiers.org/ec-code/1.2.1.5
kinetic law: MODEL1310110061#

metaR ASCBt4
fast: false
reversible: true
kinetic law: MODEL1310110061#
is: SBO:0000185
notes: GENE_ASSOCIATION: (9962.2) or (9963.1) or (9962.1) or (9963.2) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10471399,PMID:10556483,PMID:10556521,PMID:10631088,PMID:15705056 NOTES:NCD
type: Reaction
name: L-ascorbate transport via proton symport
reactant: MODEL1310110061#
product: MODEL1310110061#
is described by: ECO:0000269
modifier: MODEL1310110061#

metaM HC00342 m
type: Species
has only substance units: false
name: cis-aconitate(3-)
is: SBO:0000247
boundary condition: false
is: CHEBI:16383
notes: FORMULA: C6H3O6 CHARGE: -3 INCHI: InChI=1S/C6H6O6/c7-4(8)1-3(6(11)12)2-5(9)10/h1H,2H2,(H,7,8)(H,9,10)(H,11,12)/p-3/b3-1- EHMN_ABBREVIATION: C00417
constant: false
initial concentration: 1.0
initial amount: NaN

metaR RE1447N
reversible: true
reactant: MODEL1310110061#
name: RE1447
product: MODEL1310110061#
type: Reaction
kinetic law: MODEL1310110061#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Phosphatidylinositol phosphate metabolism EC Number: 3.1.3.66 Confidence Level: 0 AUTHORS: PMID:11756679,PMID:7556092,PMID:7567999,PMID:9295334,PMID:9356448 NOTES:
is: SBO:0000176
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110061#_582a4945_b1eb_4e80_a99d_1debbb4e6da6
initial amount: NaN
is encoded by: hsa:3284
has only substance units: false
is: P26439
type: Species
name: HSD3B2
boundary condition: true
is: SBO:0000252
constant: false
initial concentration: NaN

metaM thym c
name: Thymine
initial amount: NaN
is: C00178
is: HMDB00262
constant: false
boundary condition: false
is: CHEBI:17821
has only substance units: false
is: SBO:0000247
notes: FORMULA: C5H6N2O2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00170 EHMN_ABBREVIATION: C00178
type: Species
initial concentration: 1.0

metaR COAtn
name: coenzyme A transport, nuclear
product: MODEL1310110061#
reactant: MODEL1310110061#
is: SBO:0000185
reversible: true
is described by: ECO:0000000
type: Reaction
kinetic law: MODEL1310110061#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: NOTES:NCD
fast: false

metaM no e
is: CHEBI:16480
initial concentration: 1.0
has only substance units: false
initial amount: NaN
notes: FORMULA: NO CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00415 EHMN_ABBREVIATION: C00533
boundary condition: false
is: C00533
is: HMDB03378
constant: false
type: Species
name: Nitric oxide
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110061#_41029b92_eca1_4c1d_b035_09e6b8ac0afd
name: MGST3
boundary condition: true
is: O14880
constant: false
initial amount: NaN
is: SBO:0000252
is encoded by: hsa:4259
initial concentration: NaN
type: Species
has only substance units: false

metaM pram c
is: CHEBI:58681
is: HMDB01128
constant: false
has only substance units: false
type: Species
initial concentration: 1.0
is: C03090
notes: FORMULA: C5H11NO7P CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC01053 EHMN_ABBREVIATION: C03090
name: 5-Phospho-beta-D-ribosylamine
initial amount: NaN
is: SBO:0000247
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110061#_2cafa72f_5db2_46b3_9a78_096e981a9236
has only substance units: false
is: P36269
boundary condition: true
initial amount: NaN
is: SBO:0000252
type: Species
is encoded by: hsa:2687
name: GGT5
constant: false
initial concentration: NaN

metaM tetpent3 c
boundary condition: false
initial concentration: 1.0
name: tetracosapentaenoic acid, n-3
type: Species
initial amount: NaN
has only substance units: false
constant: false
is: HMDB06323
notes: FORMULA: C24H37O2 CHARGE: -1 INCHI: InChI=1/C24H38O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-24(25)26/h3-4,6-7,9-10,12-13,15-16H,2,5,8,11,14,17-23H2,1H3,(H,25,26)/b4-3-,7-6-,10-9-,13-12-,16-15-
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110061#_24dbb370_38df_4035_8d86_d632c7df75ea
is encoded by: hsa:4710
constant: false
initial concentration: NaN
has only substance units: false
is: O95168
initial amount: NaN
is: SBO:0000252
type: Species
name: NDUFB4
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110061#_525e3255_2faa_4875_bd30_fffc371a4869
is: SBO:0000252
initial amount: NaN
initial concentration: NaN
constant: false
has only substance units: false
type: Species
boundary condition: true
is encoded by: hsa:1717
is: Q9UBM7
name: DHCR7

metaR FDH
reactant: MODEL1310110061#
is version of: http://identifiers.org/ec-code/1.5.1.6
modifier: MODEL1310110061#
is described by: ECO:0000304
reversible: false
is: SBO:0000176
product: MODEL1310110061#
name: formate dehydrogenase
fast: false
type: Reaction
notes: GENE_ASSOCIATION: (10840.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.2.1.2 Confidence Level: 2 AUTHORS: NOTES:
kinetic law: MODEL1310110061#

metaR PROSTGE1t
is: SBO:0000185
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (6578.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12507753,PMID:8787677,PMID:9334206 NOTES:NJ
kinetic law: MODEL1310110061#
reactant: MODEL1310110061#
product: MODEL1310110061#
fast: false
type: Reaction
name: prostaglandin transport via bicarbonate countertransport
modifier: MODEL1310110061#
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110061#_778e2eb5_414c_4663_b582_a0038d47cef4
boundary condition: true
is: B4DYG5
name: PI4KA
is encoded by: hsa:5297
has only substance units: false
initial amount: NaN
is: SBO:0000252
type: Species
constant: false
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110061#_36a038c3_bcb2_44a2_83ab_6b01e2aa3463
initial concentration: NaN
initial amount: NaN
is: SBO:0000252
boundary condition: true
constant: false
type: Species
name: ADSL
has only substance units: false
is encoded by: hsa:158

metaM h x
notes: FORMULA: H CHARGE: 1 INCHI: " HEPATONET_1.0_ABBREVIATION: HC00083 EHMN_ABBREVIATION: C00080
is: SBO:0000247
is: C00080
has only substance units: false
constant: false
name: proton
initial concentration: 1.0
is: CHEBI:24636
is: http://identifiers.org/pubchem.compound/3380
type: Species
initial amount: NaN
boundary condition: false

metaR GGH 5DHFe
is version of: http://identifiers.org/ec-code/3.4.19.9
kinetic law: MODEL1310110061#
name: Gamma-glutamyl hydrolase (5DHF), extracellular
type: Reaction
product: MODEL1310110061#
is: SBO:0000176
modifier: MODEL1310110061#
fast: false
reversible: false
is described by: ECO:0000000
reactant: MODEL1310110061#
notes: GENE_ASSOCIATION: (8836.1) SUBSYSTEM: Folate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:11375437,PMID:2867095,PMID:9614206 NOTES:REMOVES EITHER ONE OR TWO GLUTAMYL RESIDUES WITH A REACTION (WILL ONLY REPRESENT 1) - last step from 5-glutamyl to monoglutamyl is in one step IT

metaM retn e
initial concentration: 1.0
boundary condition: false
type: Species
notes: FORMULA: C20H27O2 CHARGE: -1 INCHI: InChI=1S/C20H28O2/c1-15(8-6-9-16(2)14-19(21)22)11-12-18-17(3)10-7-13-20(18,4)5/h6,8-9,11-12,14H,7,10,13H2,1-5H3,(H,21,22)/p-1/b9-6+,12-11+,15-8+,16-14+ HEPATONET_1.0_ABBREVIATION: HC00532 EHMN_ABBREVIATION: C00777
has only substance units: false
initial amount: NaN
is: HMDB01852
constant: false
is: CHEBI:35291
is: SBO:0000247
name: all-trans-retinoate

metaR RE1447M
modifier: MODEL1310110061#
is: SBO:0000176
is described by: ECO:0000000
reversible: true
reactant: MODEL1310110061#
fast: false
notes: GENE_ASSOCIATION: (54995.1) SUBSYSTEM: Phosphatidylinositol phosphate metabolism EC Number: 3.1.3.66 Confidence Level: 0 AUTHORS: PMID:11756679,PMID:7556092,PMID:7567999,PMID:9295334,PMID:9356448 NOTES:
is version of: http://identifiers.org/ec-code/2.3.1.41
product: MODEL1310110061#
type: Reaction
kinetic law: MODEL1310110061#
name: RE1447

http://identifiers.org/biomodels.db/MODEL1310110061#_a9b8bb84_e388_450c_9e12_69f8d54cc651
initial concentration: NaN
initial amount: NaN
has only substance units: false
type: Species
is encoded by: hsa:728226
is: SBO:0000252
constant: false
name: _728226_1_m
boundary condition: true

metaM pi m
is: HMDB00973
constant: false
initial concentration: 1.0
is: C00009
has only substance units: false
name: hydrogenphosphate
initial amount: NaN
is: SBO:0000247
notes: FORMULA: HO4P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00019 EHMN_ABBREVIATION: C00009
is: CHEBI:43474
type: Species
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110061#_4ad3f821_e33e_4840_b44d_18821c8aaaea
initial concentration: NaN
initial amount: NaN
boundary condition: true
name: LTC4S
is encoded by: hsa:4056
has only substance units: false
constant: false
type: Species
is: SBO:0000252

metaM cdpchol c
name: CDPcholine
initial concentration: 1.0
boundary condition: false
is: SBO:0000247
type: Species
notes: FORMULA: C14H25N4O11P2 CHARGE: -1 INCHI: InChI=1S/C14H26N4O11P2/c1-18(2,3)6-7-26-30(22,23)29-31(24,25)27-8-9-11(19)12(20)13(28-9)17-5-4-10(15)16-14(17)21/h4-5,9,11-13,19-20H,6-8H2,1-3H3,(H3-,15,16,21,22,23,24,25)/t9-,11-,12-,13-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00263 EHMN_ABBREVIATION: C00307
initial amount: NaN
is: CHEBI:16436
constant: false
has only substance units: false
is: HMDB01413

http://identifiers.org/biomodels.db/MODEL1310110061#_5a34e592_ea78_46c7_9e97_565d806dc291
constant: false
initial amount: NaN
is: Q92536
is encoded by: hsa:9057
initial concentration: NaN
is: SBO:0000252
boundary condition: true
type: Species
has only substance units: false
name: SLC7A6

metaM dcholcoa c
is: CHEBI:28701
initial concentration: 1.0
boundary condition: false
notes: FORMULA: C45H70N7O19P3S CHARGE: -4 INCHI: InChI=1S/C45H74N7O19P3S/c1-24(27-7-8-28-34-29(11-14-45(27,28)5)44(4)13-10-26(53)18-25(44)19-30(34)54)6-9-33(56)75-17-16-47-32(55)12-15-48-41(59)38(58)43(2,3)21-68-74(65,66)71-73(63,64)67-20-31-37(70-72(60,61)62)36(57)42(69-31)52-23-51-35-39(46)49-22-50-40(35)52/h22-31,34,36-38,42,53-54,57-58H,6-21H2,1-5H3,(H,47,55)(H,48,59)(H,63,64)(H,65,66)(H2,46,49,50)(H2,60,61,62)/t24-,25+,26-,27-,28+,29+,30-,31-,34+,36-,37-,38+,42-,44+,45-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01426 EHMN_ABBREVIATION: C05337
constant: false
initial amount: NaN
name: chenodeoxycholoyl coenzyme a
is: SBO:0000247
type: Species
has only substance units: false
is: HMDB06292

http://identifiers.org/biomodels.db/MODEL1310110061#_395bfdaf_7dc7_4392_8d44_0d36f09db6b4
boundary condition: true
name: UROC1
type: Species
has only substance units: false
is: SBO:0000252
is: Q68CJ7
initial amount: NaN
constant: false
is encoded by: hsa:131669
initial concentration: NaN

metaR EX dgtp LPAREN e RPAREN
kinetic law: MODEL1310110061#
reactant: MODEL1310110061#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of dGTP
type: Reaction

metaM thym e
initial amount: NaN
is: HMDB00262
type: Species
has only substance units: false
initial concentration: 1.0
constant: false
notes: FORMULA: C5H6N2O2 CHARGE: 0 INCHI: InChI=1S/C5H6N2O2/c1-3-2-6-5(9)7-4(3)8/h2H,1H3,(H2,6,7,8,9) HEPATONET_1.0_ABBREVIATION: HC00170 EHMN_ABBREVIATION: C00178
boundary condition: false
is: CHEBI:17821
name: thymine
is: SBO:0000247

metaM nadp c
boundary condition: false
has only substance units: false
notes: FORMULA: C21H25N7O17P3 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00016 EHMN_ABBREVIATION: C00006
is: C00006
initial concentration: 1.0
constant: false
is: SBO:0000247
initial amount: NaN
is: CHEBI:58349
name: Nicotinamide adenine dinucleotide phosphate
type: Species
is: HMDB00217

metaR DGULND
reactant: MODEL1310110061#
notes: GENE_ASSOCIATION: SUBSYSTEM: Pentose phosphate pathway EC Number: 4.1.1.34 Confidence Level: 2 AUTHORS: PMID:6821187 NOTES:NCD
product: MODEL1310110061#
type: Reaction
is described by: ECO:0000000
name: dehydro-L-gulonate decarboxylase
fast: false
kinetic law: MODEL1310110061#
reversible: true
is: SBO:0000176

metaM estradiol c
is: HMDB00151
is: CHEBI:16469
is: SBO:0000247
type: Species
has only substance units: false
name: estradiol
initial concentration: 1.0
boundary condition: false
initial amount: NaN
constant: false
notes: FORMULA: C18H24O2 CHARGE: 0 INCHI: InChI=1S/C18H24O2/c1-18-9-8-14-13-5-3-12(19)10-11(13)2-4-15(14)16(18)6-7-17(18)20/h3,5,10,14-17,19-20H,2,4,6-9H2,1H3/t14-,15-,16+,17+,18+/m1/s1 EHMN_ABBREVIATION: C00951

metaR NACHEXA21ly
kinetic law: MODEL1310110061#
fast: false
name: beta-N-acetylhexosaminidase A, lysosomal
reversible: false
reactant: MODEL1310110061#
is version of: http://identifiers.org/ec-code/3.2.1.52
type: Reaction
modifier: MODEL1310110061#
is described by: ECO:0000000
product: MODEL1310110061#
is: SBO:0000176
notes: GENE_ASSOCIATION: (3073.1) or (3073.1 and 3074.1) SUBSYSTEM: Keratan sulfate degradation EC Number: Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12706724,PMID:8993162 NOTES:Note that this reaction is specific to beta-N-acetylhexosaminidase A and cannot be catalyzed by beta-N-acetylhexosaminidase B (or presumably beta-N-acetylhexosaminidase S). This is also a lumped reaction, representing the cleavage of GalNAc4S or GalNAc6S and N-acetylgalactosamine 4-sulfatase or 6-sulfatase. NCD

http://identifiers.org/biomodels.db/MODEL1310110061#_cfa4334f_8c2b_48ba_ae5b_a1efd7a2fb63
constant: false
name: COX7B
is: SBO:0000252
is: P24311
is encoded by: hsa:1349
boundary condition: true
initial amount: NaN
initial concentration: NaN
type: Species
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110061#_7f3d493d_03cd_4a67_81e6_8ef9109a13e9
boundary condition: true
has only substance units: false
is: SBO:0000252
is: A5PKZ1
initial amount: NaN
initial concentration: NaN
name: GALNT5
type: Species
constant: false
is encoded by: hsa:11227

metaM so4 m
is: CHEBI:16189
name: sulfate
is: HMDB01448
boundary condition: false
notes: FORMULA: O4S CHARGE: -2 INCHI: InChI=1S/H2O4S/c1-5(2,3)4/h(H2,1,2,3,4)/p-2 HEPATONET_1.0_ABBREVIATION: HC00062 EHMN_ABBREVIATION: C00059
is: SBO:0000247
type: Species
has only substance units: false
initial amount: NaN
initial concentration: 1.0
constant: false

metaR FAOXTC182TC162m
kinetic law: MODEL1310110061#
product: MODEL1310110061#
reactant: MODEL1310110061#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation trans(C18:2-->C16:2)m
type: Reaction

metaM itaccoa m
is: HMDB03377
initial concentration: 1.0
has only substance units: false
constant: false
boundary condition: false
is: SBO:0000247
notes: FORMULA: C26H35N7O19P3S CHARGE: -5 INCHI: InChI=1S/C26H40N7O19P3S/c1-13(25(39)40)8-16(35)56-7-6-28-15(34)4-5-29-23(38)20(37)26(2,3)10-49-55(46,47)52-54(44,45)48-9-14-19(51-53(41,42)43)18(36)24(50-14)33-12-32-17-21(27)30-11-31-22(17)33/h11-12,14,18-20,24,36-37H,1,4-10H2,2-3H3,(H,28,34)(H,29,38)(H,39,40)(H,44,45)(H,46,47)(H2,27,30,31)(H2,41,42,43)/p-5/t14-,18-,19-,20+,24-/m1/s1 EHMN_ABBREVIATION: C00531
is: CHEBI:57381
initial amount: NaN
name: itaconyl-CoA(5-)
type: Species

http://identifiers.org/biomodels.db/MODEL1310110061#_c8d44aae_b529_4134_b82b_f5372ee5f4b6
constant: false
is: Q9UFY1
has only substance units: false
type: Species
is encoded by: hsa:5335
initial amount: NaN
initial concentration: NaN
is: SBO:0000252
name: PLCG1
boundary condition: true

metaR TXA2te
is described by: ECO:0000000
is: SBO:0000185
name: thromboxane A2 transport
reactant: MODEL1310110061#
kinetic law: MODEL1310110061#
reversible: true
type: Reaction
product: MODEL1310110061#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:unknown mechanism for transport - known to be secreted from cells - unknown mechanism or pathway, TXA2tc -> TXA2te to get to EC space NJ

metaR RE3346M
name: RE3346
is version of: http://identifiers.org/ec-code/1.2.1.3
reversible: true
reactant: MODEL1310110061#
kinetic law: MODEL1310110061#
modifier: MODEL1310110061#
notes: GENE_ASSOCIATION: (217.1) or (219.1) or (501.1) SUBSYSTEM: Bile acid synthesis EC Number: 1.2.1.3 Confidence Level: 0 AUTHORS: PMID:1591235 NOTES:
product: MODEL1310110061#
is described by: ECO:0000000
is: SBO:0000176
fast: false
type: Reaction

metaR CYSALANaEx
is: SBO:0000185
modifier: MODEL1310110061#
is described by: ECO:0000269
product: MODEL1310110061#
kinetic law: MODEL1310110061#
fast: false
reversible: false
name: L-alanine/L-cysteine Na-dependent exchange (Cys-L in)
reactant: MODEL1310110061#
notes: GENE_ASSOCIATION: (6509.1) or (6510.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14530974 NOTES:SAB see Kanai and Hediger 2004 (2003), PMID 14530974
type: Reaction

metaR ASNALANaEx
reversible: false
product: MODEL1310110061#
fast: false
kinetic law: MODEL1310110061#
is described by: ECO:0000269
is: SBO:0000185
modifier: MODEL1310110061#
notes: GENE_ASSOCIATION: (6510.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14530974 NOTES:SAB see Kanai and Hediger 2004 (2003), PMID 14530974
type: Reaction
reactant: MODEL1310110061#
name: L-alanine/L-asparagine Na-dependent exchange (Asn-L in)

metaR EX mercplaccys LPAREN e RPAREN
kinetic law: MODEL1310110061#
reactant: MODEL1310110061#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 3-mercaptolactate-cysteine disulfide exchange
type: Reaction

metaM dcmp n
notes: FORMULA: C9H12N3O7P CHARGE: -2 INCHI: InChI=1S/C9H14N3O7P/c10-7-1-2-12(9(14)11-7)8-3-5(13)6(19-8)4-18-20(15,16)17/h1-2,5-6,8,13H,3-4H2,(H2,10,11,14)(H2,15,16,17)/p-2/t5-,6+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00217 EHMN_ABBREVIATION: C00239
initial amount: NaN
constant: false
boundary condition: false
type: Species
initial concentration: 1.0
is: SBO:0000247
is: HMDB01202
is: CHEBI:57566
has only substance units: false
name: dCMP(2-)

metaR EX 6thf LPAREN e RPAREN
kinetic law: MODEL1310110061#
reactant: MODEL1310110061#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: hexaglutamyl folate (THF) exchange
type: Reaction

metaM pi n
boundary condition: false
is: CHEBI:43474
notes: FORMULA: HO4P CHARGE: -2 INCHI: InChI=1S/H3O4P/c1-5(2,3)4/h(H3,1,2,3,4)/p-2 HEPATONET_1.0_ABBREVIATION: HC00019 EHMN_ABBREVIATION: C00009
has only substance units: false
initial amount: NaN
is: HMDB00973
is: SBO:0000247
initial concentration: 1.0
name: hydrogenphosphate
type: Species
constant: false

metaR GGH 6THFe
modifier: MODEL1310110061#
reactant: MODEL1310110061#
name: Gamma-glutamyl hydrolase (6THF), extracellular
product: MODEL1310110061#
type: Reaction
is: SBO:0000176
notes: GENE_ASSOCIATION: (8836.1) SUBSYSTEM: Folate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:11375437,PMID:2867095,PMID:9614206 NOTES:REMOVES EITHER ONE OR TWO GLUTAMYL RESIDUES WITH A REACTION (WILL ONLY REPRESENT 1) IT
is described by: ECO:0000000
fast: false
is version of: http://identifiers.org/ec-code/3.4.19.9
kinetic law: MODEL1310110061#
reversible: false

metaM no c
initial concentration: 1.0
is: SBO:0000247
is: CHEBI:16480
notes: FORMULA: NO CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00415 EHMN_ABBREVIATION: C00533
boundary condition: false
initial amount: NaN
is: C00533
is: HMDB03378
type: Species
constant: false
name: Nitric oxide
has only substance units: false

metaR TTDCAtr
reactant: MODEL1310110061#
is described by: ECO:0000269
type: Reaction
product: MODEL1310110061#
kinetic law: MODEL1310110061#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10811962,PMID:11161786 NOTES:
is: SBO:0000185
name: tetradecanoate (transport)
reversible: true
fast: false

metaR RAI2
reactant: MODEL1310110061#
is: SBO:0000176
product: MODEL1310110061#
kinetic law: MODEL1310110061#
notes: GENE_ASSOCIATION: SUBSYSTEM: Vitamin A metabolism EC Number: 5.2.1.3 Confidence Level: 2 AUTHORS: PMID:1503811 NOTES:IT
type: Reaction
fast: false
is described by: ECO:0000000
name: retinal isomerase (9-cis)
reversible: true

metaR SBT Dtde
fast: false
reactant: MODEL1310110061#
product: MODEL1310110061#
is described by: ECO:0000134
is: SBO:0000185
kinetic law: MODEL1310110061#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: added during gap-filling. Diffusion into the blood is assumed. NOTES:added during gap-filling. Diffusion into the blood is assumed.
reversible: true
name: D-sorbitol transport, extracellular
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110061#_4b5e6b0f_cb7a_40e3_a4ea_389c35f00922
name: CA4
constant: false
is: Q6FHI7
is: SBO:0000252
initial amount: NaN
initial concentration: NaN
has only substance units: false
boundary condition: true
type: Species
is encoded by: hsa:762

metaM tetpent3 e
type: Species
boundary condition: false
initial concentration: 1.0
name: tetracosapentaenoic acid, n-3
constant: false
has only substance units: false
is: HMDB06323
is: SBO:0000247
notes: FORMULA: C24H37O2 CHARGE: -1 INCHI: InChI=1/C24H38O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-24(25)26/h3-4,6-7,9-10,12-13,15-16H,2,5,8,11,14,17-23H2,1H3,(H,25,26)/b4-3-,7-6-,10-9-,13-12-,16-15-
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110061#_f14c27bd_2d3a_4cc7_b60e_4214b3fc20c8
name: ADSSL1
initial amount: NaN
initial concentration: NaN
is: B3KTV4
boundary condition: true
constant: false
is encoded by: hsa:122622
type: Species
is: SBO:0000252
has only substance units: false

metaM so4 l
notes: FORMULA: O4S CHARGE: -2 INCHI: InChI=1S/H2O4S/c1-5(2,3)4/h(H2,1,2,3,4)/p-2 HEPATONET_1.0_ABBREVIATION: HC00062 EHMN_ABBREVIATION: C00059
constant: false
name: sulfate
is: HMDB01448
initial concentration: 1.0
is: CHEBI:16189
is: SBO:0000247
type: Species
has only substance units: false
boundary condition: false
initial amount: NaN

metaR EX HC02206 LPAREN e RPAREN
kinetic law: MODEL1310110061#
reactant: MODEL1310110061#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: prostaglandin C1(1-) exchange
type: Reaction

metaM h2o2 x
is: HMDB03125
is: SBO:0000247
name: Hydrogen peroxide
is: C00027
constant: false
has only substance units: false
boundary condition: false
type: Species
initial amount: NaN
initial concentration: 1.0
is: CHEBI:16240
notes: FORMULA: H2O2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00036 EHMN_ABBREVIATION: C00027

metaM acac c
type: Species
initial amount: NaN
is: CHEBI:13705
initial concentration: 1.0
boundary condition: false
is: SBO:0000247
notes: FORMULA: C4H5O3 CHARGE: -1 INCHI: InChI=1S/C4H6O3/c1-3(5)2-4(6)7/h2H2,1H3,(H,6,7)/p-1 HEPATONET_1.0_ABBREVIATION: HC00159 EHMN_ABBREVIATION: C00164
constant: false
name: acetoacetate
is: HMDB00060
has only substance units: false

metaR RE2541E
reactant: MODEL1310110061#
is: SBO:0000176
type: Reaction
is described by: ECO:0000000
name: RE2541
product: MODEL1310110061#
fast: false
reversible: true
kinetic law: MODEL1310110061#
is version of: http://identifiers.org/ec-code/3.2.1.31
notes: GENE_ASSOCIATION: (9365.1) SUBSYSTEM: Miscellaneous EC Number: 3.2.1.31 Confidence Level: 0 AUTHORS: PMID:10191290 NOTES:
modifier: MODEL1310110061#

metaM o2 x
has only substance units: false
constant: false
notes: FORMULA: O2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00017 EHMN_ABBREVIATION: C00007
initial concentration: 1.0
is: HMDB01377
is: SBO:0000247
name: O2
initial amount: NaN
boundary condition: false
type: Species
is: C00007
is: CHEBI:15379

metaM 4ppcys m
boundary condition: false
constant: false
has only substance units: false
initial concentration: 1.0
type: Species
notes: FORMULA: C12H20N2O9PS CHARGE: -3 INCHI: InChI=1S/C12H23N2O9PS/c1-12(2,6-23-24(20,21)22)9(16)10(17)13-4-3-8(15)14-7(5-25)11(18)19/h7,9,16,25H,3-6H2,1-2H3,(H,13,17)(H,14,15)(H,18,19)(H2,20,21,22)/p-3/t7-,9-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01276 EHMN_ABBREVIATION: C04352
is: HMDB01117
is: CHEBI:59458
initial amount: NaN
name: N-[(R)-4-phosphonatopantothenoyl]-L-cysteinate(3-)
is: SBO:0000247

metaR HGNTOR
is: SBO:0000176
product: MODEL1310110061#
kinetic law: MODEL1310110061#
notes: GENE_ASSOCIATION: (3081.1) SUBSYSTEM: Tyrosine metabolism EC Number: 1.13.11.5 Confidence Level: 4 AUTHORS: NOTES:
is version of: http://identifiers.org/ec-code/1.13.11.5
is described by: ECO:0000269
type: Reaction
name: Homogentisate:oxygen 1,2-oxidoreductase (decyclizing)
reactant: MODEL1310110061#
modifier: MODEL1310110061#
fast: false
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110061#_dadbd437_7f49_44ac_a45c_c7b4c107a54d
is encoded by: hsa:8604
is: SBO:0000252
constant: false
name: SLC25A12
is: O75746
initial concentration: NaN
type: Species
initial amount: NaN
has only substance units: false
boundary condition: true

metaM vacc e
initial concentration: 1.0
constant: false
name: trans-vaccenate
has only substance units: false
initial amount: NaN
type: Species
boundary condition: false
is: SBO:0000247
notes: FORMULA: C18H33O2 CHARGE: -1 INCHI: InChI=1S/C18H34O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20/h7-8H,2-6,9-17H2,1H3,(H,19,20)/p-1/b8-7+
is: CHEBI:30828

metaM 5tedtricoa m
notes: FORMULA: C35H52N7O17P3S CHARGE: -4
initial concentration: 1.0
initial amount: NaN
name: 5,8,11-tetradecatrienoylcoa
is: SBO:0000247
constant: false
boundary condition: false
type: Species
has only substance units: false
is: HMDB02288

metaR G6PDA
name: glucosamine-6-phosphate deaminase
modifier: MODEL1310110061#
reversible: false
notes: GENE_ASSOCIATION: (132789.1) or (10007.1) SUBSYSTEM: Aminosugar metabolism EC Number: 3.5.99.6 Confidence Level: 4 AUTHORS: PMID:9714720 NOTES:Previously EC 5.3.1.10
product: MODEL1310110061#
is version of: http://identifiers.org/ec-code/3.5.99.6
is described by: ECO:0000269
kinetic law: MODEL1310110061#
type: Reaction
is: SBO:0000176
fast: false
reactant: MODEL1310110061#

metaR EX val L LPAREN e RPAREN
kinetic law: MODEL1310110061#
reactant: MODEL1310110061#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: L-Valine exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110061#_95e937ca_1c89_4b62_b563_55415cae4b20
is: P32019
name: INPP5B
is encoded by: hsa:3633
boundary condition: true
initial amount: NaN
initial concentration: NaN
is: SBO:0000252
has only substance units: false
constant: false
type: Species

metaR COAtp
name: coenzyme A transport, peroxisomal
reversible: true
product: MODEL1310110061#
type: Reaction
is: SBO:0000185
fast: false
is described by: ECO:0000000
reactant: MODEL1310110061#
kinetic law: MODEL1310110061#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD

metaM hco3 e
type: Species
initial amount: NaN
is: SBO:0000247
constant: false
is: C00288
is: HMDB00595
name: Bicarbonate
has only substance units: false
initial concentration: 1.0
boundary condition: false
is: CHEBI:17544
notes: FORMULA: CHO3 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00253 EHMN_ABBREVIATION: C00288

metaR EX ha pre1 LPAREN e RPAREN
kinetic law: MODEL1310110061#
reactant: MODEL1310110061#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: hyaluronan biosynthesis, precursor 1 exchange
type: Reaction

metaM retn c
initial concentration: 1.0
notes: FORMULA: C20H27O2 CHARGE: -1 INCHI: InChI=1S/C20H28O2/c1-15(8-6-9-16(2)14-19(21)22)11-12-18-17(3)10-7-13-20(18,4)5/h6,8-9,11-12,14H,7,10,13H2,1-5H3,(H,21,22)/p-1/b9-6+,12-11+,15-8+,16-14+ HEPATONET_1.0_ABBREVIATION: HC00532 EHMN_ABBREVIATION: C00777
boundary condition: false
has only substance units: false
type: Species
initial amount: NaN
is: HMDB01852
name: all-trans-retinoate
constant: false
is: CHEBI:35291
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110061#_79d3d6bd_80cd_46e5_92f8_73368f2277c7
constant: false
type: Species
is: SBO:0000252
has only substance units: false
is encoded by: hsa:5631
name: PRPS1
initial concentration: NaN
boundary condition: true
is: P60891
initial amount: NaN

metaR DESAT20 1
modifier: MODEL1310110061#
reversible: false
fast: false
notes: GENE_ASSOCIATION: (3992.1) SUBSYSTEM: Fatty acid synthesis EC Number: 1.14.19.1 Confidence Level: 4 AUTHORS: NOTES:for homo sapiens, noted to actually be NADH-cyt b5, using NADH at present NJ
name: fatty acyl-CoA desaturase (n-C20:3CoA -> n-C20:4CoA)
kinetic law: MODEL1310110061#
reactant: MODEL1310110061#
product: MODEL1310110061#
is described by: ECO:0000000
type: Reaction
is: SBO:0000176

metaM chol e
constant: false
type: Species
is: HMDB00097
is: CHEBI:15354
name: Choline
notes: FORMULA: C5H14NO CHARGE: 1 HEPATONET_1.0_ABBREVIATION: HC00112 EHMN_ABBREVIATION: C00114
initial concentration: 1.0
boundary condition: false
is: C00114
is: SBO:0000247
initial amount: NaN
has only substance units: false

metaR MTHFDm
is version of: http://identifiers.org/ec-code/6.3.4.3
name: methylenetetrahydrofolate dehydrogenase (NADP), mitochondrial
modifier: MODEL1310110061#
product: MODEL1310110061#
reversible: true
fast: false
kinetic law: MODEL1310110061#
is: SBO:0000176
notes: GENE_ASSOCIATION: (25902.1) or (10797.1) SUBSYSTEM: Folate metabolism EC Number: 1.5.1.5 Confidence Level: 4 AUTHORS: PMID:12937168,PMID:8218174 NOTES:NCD
is version of: http://identifiers.org/ec-code/3.5.4.9
type: Reaction
is described by: ECO:0000269
reactant: MODEL1310110061#

http://identifiers.org/biomodels.db/MODEL1310110061#_43ce4fe3_e7ae_4b51_a5db_0e27c5e5f978
has only substance units: false
initial concentration: NaN
type: Species
constant: false
is encoded by: hsa:51557
is: Q5TDP6
initial amount: NaN
is: SBO:0000252
boundary condition: true
name: LGSN

metaR RE2649C
reactant: MODEL1310110061#
is version of: http://identifiers.org/ec-code/3.1.2.2
fast: false
is: SBO:0000176
name: RE2649
type: Reaction
product: MODEL1310110061#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (641372.1) or (641371.1) or (570.1) SUBSYSTEM: Bile acid synthesis EC Number: 3.1.2.2 Confidence Level: 0 AUTHORS: PMID:11013297 NOTES:
modifier: MODEL1310110061#
kinetic law: MODEL1310110061#
is version of: http://identifiers.org/ec-code/2.3.1.65
reversible: true

metaR r1459
product: MODEL1310110061#
kinetic law: MODEL1310110061#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: 1.3.1.27 Confidence Level: 0 AUTHORS: NOTES:
name: Transport reaction
reactant: MODEL1310110061#
reversible: true
fast: false
is: SBO:0000185
type: Reaction

metaR r0385
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 1.2.4.4 Confidence Level: 0 AUTHORS: PMID:11839747,PMID:12387880,PMID:15576032 NOTES:
kinetic law: MODEL1310110061#
fast: false
type: Reaction
is described by: ECO:0000000
reversible: false
is: SBO:0000176
reactant: MODEL1310110061#
name: 3-methyl-2-oxobutanoate:[dihydrolipoyllysine-residue (2-methylpropanoyl)transferase] lipoyllysine 2-oxidoreductase (decarboxylating, acceptor-2-methylpropanoylating) EC:1.2.4.4
product: MODEL1310110061#

metaM crm hs g
constant: false
initial concentration: 1.0
is: CHEBI:52639
name: N-acylsphingosine
is: SBO:0000247
initial amount: NaN
has only substance units: false
notes: FORMULA: C18H36NO2FULLRCO CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC01990 EHMN_ABBREVIATION: C00195
boundary condition: false
type: Species

metaR RE1517M
product: MODEL1310110061#
is version of: http://identifiers.org/ec-code/1.3.99.13
kinetic law: MODEL1310110061#
reactant: MODEL1310110061#
type: Reaction
is: SBO:0000176
name: RE1517
modifier: MODEL1310110061#
notes: GENE_ASSOCIATION: (33.1) or (51.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.99.13 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:11356167,PMID:8973539 NOTES:
fast: false
is version of: http://identifiers.org/ec-code/1.3.3.6
is described by: ECO:0000000
reversible: true

metaR FATP2t
is: SBO:0000185
kinetic law: MODEL1310110061#
product: MODEL1310110061#
name: fatty acid electroneutral transport
modifier: MODEL1310110061#
fast: false
is described by: ECO:0000269
reactant: MODEL1310110061#
reversible: true
type: Reaction
notes: GENE_ASSOCIATION: (376497.1) or (376497.2) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12856180,PMID:15522816 NOTES:electroneutral transport NJ

metaR PI45PLC
is described by: ECO:0000000
modifier: MODEL1310110061#
type: Reaction
reactant: MODEL1310110061#
name: phosphatidylinositol 4,5-bisphosphate phospholipase C
notes: GENE_ASSOCIATION: (23236.2) or (5336.1) or (9651.1) or (113026.1) or (89869.1) or (84812.1) or (5330.1) or (5335.1) or (51196.1) or (5333.1) or (5332.2) or (5331.1) or (5335.2) or (5334.1) or (5332.1) or (257068.1) or (23236.1) or (23007.1) SUBSYSTEM: Inositol phosphate metabolism EC Number: 3.1.4.11 Confidence Level: 4 AUTHORS: PMID:10702670,PMID:10702683,PMID:10760467,PMID:11022047,PMID:11022048,PMID:11118617,PMID:12117804,PMID:12213492,PMID:12416999,PMID:13333955,PMID:15140260,PMID:1644792,PMID:2167438,PMID:7607669,PMID:7612006,PMID:7633416,PMID:7789993,PMID:7835906,PMID:7849701,PMID:7890667,PMID:8530101,PMID:9345909 NOTES:NCD
kinetic law: MODEL1310110061#
product: MODEL1310110061#
reversible: false
is version of: http://identifiers.org/ec-code/3.1.4.11
fast: false
is: SBO:0000176

metaM estradiol e
constant: false
initial amount: NaN
is: HMDB00151
type: Species
boundary condition: false
name: estradiol
is: SBO:0000247
initial concentration: 1.0
has only substance units: false
is: CHEBI:16469
notes: FORMULA: C18H24O2 CHARGE: 0 INCHI: InChI=1S/C18H24O2/c1-18-9-8-14-13-5-3-12(19)10-11(13)2-4-15(14)16(18)6-7-17(18)20/h3,5,10,14-17,19-20H,2,4,6-9H2,1H3/t14-,15-,16+,17+,18+/m1/s1 EHMN_ABBREVIATION: C00951

metaR VALTA
kinetic law: MODEL1310110061#
notes: GENE_ASSOCIATION: (586.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 2.6.1.42 Confidence Level: 4 AUTHORS: PMID:6933702,PMID:9165094 NOTES:
is version of: http://identifiers.org/ec-code/2.6.1.42
type: Reaction
modifier: MODEL1310110061#
product: MODEL1310110061#
name: valine transaminase
fast: false
reactant: MODEL1310110061#
is described by: ECO:0000269
is: SBO:0000176
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110061#_4a0d45dd_0fc1_4b58_badd_9fc71914c09c
is: P34949
initial amount: NaN
initial concentration: NaN
name: MPI
is: SBO:0000252
boundary condition: true
has only substance units: false
constant: false
type: Species
is encoded by: hsa:4351

metaR r2321
reactant: MODEL1310110061#
is described by: ECO:0000000
reversible: true
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
is: SBO:0000185
kinetic law: MODEL1310110061#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
product: MODEL1310110061#
type: Reaction
fast: false

metaR RE3270C
kinetic law: MODEL1310110061#
notes: GENE_ASSOCIATION: SUBSYSTEM: Phosphatidylinositol phosphate metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:7556092 NOTES:IT - fixed proton
product: MODEL1310110061#
name: RE3270
is: SBO:0000176
is described by: ECO:0000000
reversible: true
type: Reaction
fast: false
reactant: MODEL1310110061#

http://identifiers.org/biomodels.db/MODEL1310110061#_543f242a_6f0f_4a3c_8e55_105c473d5f6c
is: SBO:0000252
boundary condition: true
has only substance units: false
type: Species
is encoded by: hsa:AF080579
name: _AF080579_1_c
initial concentration: NaN
constant: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110061#_f8c082f2_95b1_46c8_892c_706be48effae
boundary condition: true
is encoded by: hsa:1040
type: Species
initial concentration: NaN
constant: false
initial amount: NaN
name: CDS1
is: SBO:0000252
has only substance units: false
is: Q92903

http://identifiers.org/biomodels.db/MODEL1310110061#_d9fd9881_9c20_49ff_b7c6_e8b0e3a02bd4
initial concentration: NaN
is encoded by: hsa:23517
is: Q3MHC9
name: SKIV2L2
constant: false
is: SBO:0000252
has only substance units: false
boundary condition: true
initial amount: NaN
type: Species

http://identifiers.org/biomodels.db/MODEL1310110061#_47e01f1b_e6ae_4a1d_aa8b_c1052b367cb4
name: COX2
has only substance units: false
type: Species
initial amount: NaN
boundary condition: true
is encoded by: hsa:4513
constant: false
is: Q7GXZ8
is: SBO:0000252
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110061#_44019d3b_48c1_40ca_902c_e84d97b3a81d
is: SBO:0000252
boundary condition: true
initial concentration: NaN
initial amount: NaN
name: NT5C1B
is encoded by: hsa:93034
is: B3KUK6
has only substance units: false
type: Species
constant: false

metaM pyr m
initial amount: NaN
constant: false
has only substance units: false
is: CHEBI:15361
is: http://identifiers.org/pubchem.compound/3324
name: pyruvate
is: C00022
initial concentration: 1.0
is: SBO:0000247
notes: FORMULA: C3H3O3 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00032 EHMN_ABBREVIATION: C00022
is: HMDB00243
boundary condition: false
type: Species

metaR CMPSAS
modifier: MODEL1310110061#
name: CMP sialic acid synthase
is: SBO:0000176
reversible: false
is version of: http://identifiers.org/ec-code/2.7.7.43
notes: GENE_ASSOCIATION: (55907.1) SUBSYSTEM: Aminosugar metabolism EC Number: 2.7.7.43 Confidence Level: 2 AUTHORS: PMID:9689047 NOTES:NCD
reactant: MODEL1310110061#
fast: false
type: Reaction
kinetic law: MODEL1310110061#
is described by: ECO:0000304
product: MODEL1310110061#

metaR r1999
kinetic law: MODEL1310110061#
is described by: ECO:0000000
reactant: MODEL1310110061#
reversible: false
fast: false
is: SBO:0000185
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.15
product: MODEL1310110061#
modifier: MODEL1310110061#
type: Reaction

metaR RE3524R
reversible: true
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Eicosanoid metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:9755286 NOTES:
reactant: MODEL1310110061#
kinetic law: MODEL1310110061#
is: SBO:0000176
name: RE3524
is described by: ECO:0000000
type: Reaction
product: MODEL1310110061#

metaR r0384
type: Reaction
product: MODEL1310110061#
is described by: ECO:0000000
is: SBO:0000176
reactant: MODEL1310110061#
fast: false
name: 2-oxoglutarate:[dihydrolipoyllysine-residue succinyltransferase]-lipoyllysine 2-oxidoreductase (decarboxylating, acceptor-succinylating) EC:1.2.4.2
reversible: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 1.2.4.2 Confidence Level: 0 AUTHORS: PMID:10676873 NOTES:
kinetic law: MODEL1310110061#

metaR r1918
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
modifier: MODEL1310110061#
fast: false
is: SBO:0000185
reactant: MODEL1310110061#
product: MODEL1310110061#
type: Reaction
is described by: ECO:0000000
reversible: false
name: Y+LAT2 Utilized transport
kinetic law: MODEL1310110061#

metaR UMPK7n
product: MODEL1310110061#
is described by: ECO:0000269
modifier: MODEL1310110061#
is: SBO:0000176
type: Reaction
is version of: http://identifiers.org/ec-code/2.7.4.14
reversible: true
name: UMP kinase (dGTP),nuclear
fast: false
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
kinetic law: MODEL1310110061#
reactant: MODEL1310110061#

http://identifiers.org/biomodels.db/MODEL1310110061#_3216fe24_3130_4587_b7c2_66445e5fe9d1
is encoded by: hsa:10317
constant: false
name: B3GALT5
is: SBO:0000252
boundary condition: true
initial amount: NaN
type: Species
initial concentration: NaN
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110061#_f3379c2c_b380_4a06_b584_416be9361971
name: TYRP1
initial concentration: NaN
initial amount: NaN
type: Species
has only substance units: false
is: P17643
is: SBO:0000252
constant: false
boundary condition: true
is encoded by: hsa:7306

metaR r2320
reactant: MODEL1310110061#
is described by: ECO:0000000
fast: false
kinetic law: MODEL1310110061#
product: MODEL1310110061#
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
reversible: true
is: SBO:0000185

metaM glyc c
initial amount: NaN
is: HMDB00131
constant: false
type: Species
is: CHEBI:17754
has only substance units: false
initial concentration: 1.0
is: C00116
notes: FORMULA: C3H8O3 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00114 EHMN_ABBREVIATION: C00116
is: SBO:0000247
boundary condition: false
name: Glycerol

http://identifiers.org/biomodels.db/MODEL1310110061#_19d9e4fe_bf7b_4ca9_90ea_3274146fea62
initial amount: NaN
is: Q6IRT1
is: SBO:0000252
constant: false
has only substance units: false
name: ADH5
is encoded by: hsa:128
type: Species
boundary condition: true
initial concentration: NaN

metaM udpglcur c
initial amount: NaN
has only substance units: false
type: Species
constant: false
boundary condition: false
is: SBO:0000247
notes: FORMULA: C15H19N2O18P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00162 EHMN_ABBREVIATION: C00167
is: C00167
initial concentration: 1.0
is: HMDB00935
is: CHEBI:58052
name: UDP-D-glucuronate

http://identifiers.org/biomodels.db/MODEL1310110061#_20f47af1_b585_4ede_9bda_3d6d7799d124
initial amount: NaN
is: SBO:0000252
name: ALOX5
is: P09917
initial concentration: NaN
type: Species
boundary condition: true
constant: false
is encoded by: hsa:240
has only substance units: false

metaR 3MOBt2im
product: MODEL1310110061#
name: 3-methyl-2-oxobutanoate mitochondrial transport via proton symport
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:8428987 NOTES:MM
is: SBO:0000185
fast: false
reversible: false
type: Reaction
kinetic law: MODEL1310110061#
reactant: MODEL1310110061#
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110061#_ca83ba18_b9ef_4350_898d_6001d7ff5018
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:5831
constant: false
initial concentration: NaN
has only substance units: false
type: Species
is: A6NFM2
boundary condition: true
name: PYCR1

metaM thcholstoic c
initial amount: NaN
name: 3alpha,7alpha,12alpha-Trihydroxy-5beta-cholestanoate
boundary condition: false
has only substance units: false
is: HMDB03873
notes: FORMULA: C27H45O5 CHARGE: -1 INCHI: InChI=1S/C27H46O5/c1-15(6-5-7-16(2)25(31)32)19-8-9-20-24-21(14-23(30)27(19,20)4)26(3)11-10-18(28)12-17(26)13-22(24)29/h15-24,28-30H,5-14H2,1-4H3,(H,31,32)/t15-,16?,17+,18-,19-,20+,21+,22-,23+,24+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01340 EHMN_ABBREVIATION: C04722
constant: false
initial concentration: 1.0
type: Species
is: CHEBI:18402
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110061#_62173555_51e2_486b_bfb8_0238a12f1e1c
initial amount: NaN
is: SBO:0000252
is: F5H066
is encoded by: hsa:6560
type: Species
has only substance units: false
initial concentration: NaN
constant: false
boundary condition: true
name: SLC12A4

http://identifiers.org/biomodels.db/MODEL1310110061#_f9371214_540a_4b04_be7c_f01d8be06d48
boundary condition: true
is: Q5JWV8
constant: false
name: ACSL4
initial amount: NaN
type: Species
has only substance units: false
is: SBO:0000252
initial concentration: NaN
is encoded by: hsa:2182

http://identifiers.org/biomodels.db/MODEL1310110061#_75407752_122e_44c5_bf60_1117a48b24c7
type: Species
has only substance units: false
is: E9PHN8
initial amount: NaN
constant: false
boundary condition: true
is: SBO:0000252
initial concentration: NaN
name: HEPH
is encoded by: hsa:9843

http://identifiers.org/biomodels.db/MODEL1310110061#_9170bbb3_9734_41df_bef7_3e421b24666c
is encoded by: hsa:60386
type: Species
boundary condition: true
initial amount: NaN
initial concentration: NaN
is: Q9HC21
is: SBO:0000252
constant: false
name: SLC25A19
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110061#_67235949_d211_4f8c_bfd3_cf5330df818b
initial amount: NaN
is: SBO:0000252
boundary condition: true
name: SLC9A3
is: P48764
initial concentration: NaN
is encoded by: hsa:6550
has only substance units: false
constant: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110061#_eb3c0fda_9f7e_48b6_b23a_94b2f1317b58
type: Species
name: SGPP2
is encoded by: hsa:130367
has only substance units: false
is: SBO:0000252
constant: false
initial concentration: NaN
boundary condition: true
initial amount: NaN
is: Q8IWX5

http://identifiers.org/biomodels.db/MODEL1310110061#_8e22be9f_91cb_40b9_bf6e_67ab32f38a33
has only substance units: false
initial amount: NaN
is encoded by: hsa:2618
is: Q59HH3
is: SBO:0000252
boundary condition: true
name: GART
type: Species
initial concentration: NaN
constant: false

http://identifiers.org/biomodels.db/MODEL1310110061#_d5724987_806e_4aa2_84e2_1678f80fd139
is: Q8TCD5
initial amount: NaN
constant: false
is encoded by: hsa:30833
name: NT5C
boundary condition: true
type: Species
initial concentration: NaN
has only substance units: false
is: SBO:0000252

metaM hdca r
notes: FORMULA: C16H31O2 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00226 EHMN_ABBREVIATION: C00249
is: C00249
has only substance units: false
constant: false
is: HMDB00220
is: SBO:0000247
type: Species
initial amount: NaN
boundary condition: false
name: Hexadecanoate (n-C16:0)
is: CHEBI:7896
initial concentration: 1.0

metaR EX h2o LPAREN e RPAREN
kinetic law: MODEL1310110061#
reactant: MODEL1310110061#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: H2O exchange
type: Reaction

metaR r0383
kinetic law: MODEL1310110061#
fast: false
name: pyruvate:[dihydrolipoyllysine-residue acetyltransferase]-lipoyllysine 2-oxidoreductase (decarboxylating, acceptor-acetylating) EC:1.2.4.1
reversible: false
product: MODEL1310110061#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 1.2.4.1 Confidence Level: 0 AUTHORS: PMID:18032470,PMID:2323578,PMID:2748588 NOTES:
is described by: ECO:0000000
reactant: MODEL1310110061#
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110061#_0a46d786_ff19_48ac_b0e3_789bf0b6e057
initial amount: NaN
boundary condition: true
initial concentration: NaN
constant: false
name: GUSB
type: Species
is: SBO:0000252
has only substance units: false
is: P08236
is encoded by: hsa:2990

metaR r1746
product: MODEL1310110061#
reversible: false
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is: SBO:0000185
fast: false
kinetic law: MODEL1310110061#
modifier: MODEL1310110061#
reactant: MODEL1310110061#
type: Reaction
name: Y+LAT2 Utilized transport
is described by: ECO:0000000

metaR RE3244R
is described by: ECO:0000000
type: Reaction
notes: GENE_ASSOCIATION: (64834.1) SUBSYSTEM: Fatty acid synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:10970790 NOTES:
modifier: MODEL1310110061#
reversible: true
reactant: MODEL1310110061#
name: RE3244
fast: false
kinetic law: MODEL1310110061#
is: SBO:0000176
product: MODEL1310110061#

metaM asp L m
boundary condition: false
type: Species
has only substance units: false
is: SBO:0000247
notes: FORMULA: C4H6NO4 CHARGE: -1 INCHI: InChI=1S/C4H7NO4/c5-2(4(8)9)1-3(6)7/h2H,1,5H2,(H,6,7)(H,8,9)/p-1/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00055
initial concentration: 1.0
name: L-aspartate(1-)
constant: false
initial amount: NaN
is: HMDB00191
is: CHEBI:29991

metaM 42A3HP24DB c
initial concentration: 1.0
name: 4-(2-Amino-3-hydroxyphenyl)-2,4-dioxobutanoate
type: Species
is: HMDB04083
constant: false
is: C05645
has only substance units: false
is: SBO:0000247
initial amount: NaN
is: http://identifiers.org/pubchem.compound/7956
notes: FORMULA: C10H8NO5 CHARGE: -1 INCHI: InChI=1/C10H9NO5/c11-9-5(2-1-3-6(9)12)7(13)4-8(14)10(15)16/h1-3,12H,4,11H2,(H,15,16) HEPATONET_1.0_ABBREVIATION: HC01547 EHMN_ABBREVIATION: C05645
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110061#_4b017310_6846_44b8_8dc6_fd801afcb9a9
initial concentration: NaN
is: SBO:0000252
boundary condition: true
type: Species
name: AMT
has only substance units: false
is encoded by: hsa:275
initial amount: NaN
is: P48728
constant: false

metaM lys L x
constant: false
initial amount: NaN
is: SBO:0000247
boundary condition: false
type: Species
is: HMDB00182
name: L-lysinium(1+)
notes: FORMULA: C6H15N2O2 CHARGE: 1 INCHI: InChI=1S/C6H14N2O2/c7-4-2-1-3-5(8)6(9)10/h5H,1-4,7-8H2,(H,9,10)/p+1/t5-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00053 EHMN_ABBREVIATION: C00047
initial concentration: 1.0
is: CHEBI:32551
has only substance units: false

metaR RE0935E
reversible: true
notes: GENE_ASSOCIATION: (276.1) or (277.1) or (278.1) or (279.1) or (276.1) or (277.1) or (278.1) or (279.1) or (280.1) or (84569.1) SUBSYSTEM: Starch and sucrose metabolism EC Number: 3.2.1.1 Confidence Level: 0 AUTHORS: PMID:385176,PMID:8528071,PMID:890964 NOTES:
name: RE0935
is version of: http://identifiers.org/ec-code/3.2.1.1
kinetic law: MODEL1310110061#
is version of: http://identifiers.org/ec-code/3.2.1.17
modifier: MODEL1310110061#
type: Reaction
product: MODEL1310110061#
reactant: MODEL1310110061#
is: SBO:0000176
is described by: ECO:0000000
fast: false

http://identifiers.org/biomodels.db/MODEL1310110061#_8d415226_94dc_4f80_a569_4d77b5c8d487
has only substance units: false
type: Species
is encoded by: hsa:92745
initial concentration: NaN
initial amount: NaN
boundary condition: true
is: SBO:0000252
constant: false
is: Q8WUX1
name: SLC38A5

metaR EX sph1p LPAREN e RPAREN
kinetic law: MODEL1310110061#
reactant: MODEL1310110061#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Sphinganine 1-phosphate exchange
type: Reaction

metaM gdpmann c
initial concentration: 1.0
initial amount: NaN
type: Species
notes: FORMULA: C16H23N5O16P2 CHARGE: -2 INCHI: InChI=1S/C16H25N5O16P2/c17-16-19-12-6(13(28)20-16)18-3-21(12)14-10(26)8(24)5(34-14)2-33-38(29,30)37-39(31,32)36-15-11(27)9(25)7(23)4(1-22)35-15/h3-5,7-11,14-15,22-27H,1-2H2,(H,29,30)(H,31,32)(H3,17,19,20,28)/p-2/t4-,5-,7-,8-,9+,10-,11+,14-,15-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00098 EHMN_ABBREVIATION: C00096
constant: false
boundary condition: false
is: SBO:0000247
name: GDP-alpha-D-mannose(2-)
is: HMDB01163
has only substance units: false
is: CHEBI:57527

metaR TALA
is version of: http://identifiers.org/ec-code/2.2.1.2
reactant: MODEL1310110061#
notes: GENE_ASSOCIATION: (6888.1) SUBSYSTEM: Pentose phosphate pathway EC Number: 2.2.1.2 Confidence Level: 0 AUTHORS: NOTES:SMP
type: Reaction
product: MODEL1310110061#
reversible: true
modifier: MODEL1310110061#
kinetic law: MODEL1310110061#
is: SBO:0000176
is described by: ECO:0000000
name: transaldolase
fast: false

metaM HC01406 m
constant: false
boundary condition: false
initial amount: NaN
name: 3-Oxooctanoyl-CoA
initial concentration: 1.0
type: Species
has only substance units: false
is: SBO:0000247
is: CHEBI:28264
notes: FORMULA: C29H44N7O18P3S CHARGE: -4 INCHI: InChI=1S/C29H48N7O18P3S/c1-4-5-6-7-17(37)12-20(39)58-11-10-31-19(38)8-9-32-27(42)24(41)29(2,3)14-51-57(48,49)54-56(46,47)50-13-18-23(53-55(43,44)45)22(40)28(52-18)36-16-35-21-25(30)33-15-34-26(21)36/h15-16,18,22-24,28,40-41H,4-14H2,1-3H3,(H,31,38)(H,32,42)(H,46,47)(H,48,49)(H2,30,33,34)(H2,43,44,45)/t18-,22-,23-,24+,28-/m1/s1 EHMN_ABBREVIATION: C05267

metaM melanin c
boundary condition: false
is: C05606
is: HMDB04068
notes: FORMULA: C9H6NO4 CHARGE: -1 INCHI: InChI=1/C18H10N2O4/c1-5-13-9-7(3-19-13)12-10-8(11(9)17(23)15(5)21)4-20-14(10)6(2)16(22)18(12)24/h3-4,19-20H,1-2H3 EHMN_ABBREVIATION: C05606
name: Melanin
initial concentration: 1.0
is: http://identifiers.org/pubchem.compound/7929
is: SBO:0000247
type: Species
constant: false
has only substance units: false
initial amount: NaN

metaM glyc e
is: SBO:0000247
name: Glycerol
is: CHEBI:17754
is: C00116
boundary condition: false
is: HMDB00131
initial concentration: 1.0
constant: false
initial amount: NaN
type: Species
notes: FORMULA: C3H8O3 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00114 EHMN_ABBREVIATION: C00116
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110061#_55d0374c_4fe4_49cd_bbc7_cd2da053f762
is: SBO:0000252
initial amount: NaN
initial concentration: NaN
name: PRDX2
has only substance units: false
constant: false
is encoded by: hsa:7001
type: Species
boundary condition: true

metaM 2octdectecoa m
constant: false
initial concentration: 1.0
has only substance units: false
notes: FORMULA: C39H58N7O17P3S CHARGE: -4
name: 2,6,9,12-octadecatetraenoylcoa
type: Species
boundary condition: false
is: HMDB02288
is: SBO:0000247
initial amount: NaN

metaR ETFQO
reversible: false
type: Reaction
is described by: ECO:0000000
is: SBO:0000176
name: Electron transfer flavoprotein-ubiquinone oxidoreductase
product: MODEL1310110061#
notes: GENE_ASSOCIATION: (2110.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.5.5.1 Confidence Level: 4 AUTHORS: PMID:10444348,PMID:12049629 NOTES:TV Ruzicka F, JBC, 1977
reactant: MODEL1310110061#
is version of: http://identifiers.org/ec-code/1.5.5.1
fast: false
kinetic law: MODEL1310110061#
modifier: MODEL1310110061#

metaM pmtcrn m
boundary condition: false
has only substance units: false
constant: false
type: Species
is: HMDB00222
is: SBO:0000247
name: L-palmitoylcarnitine
notes: FORMULA: C23H45NO4 CHARGE: 0 INCHI: InChI=1S/C23H45NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-23(27)28-21(19-22(25)26)20-24(2,3)4/h21H,5-20H2,1-4H3/t21-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01034 EHMN_ABBREVIATION: C02990
initial concentration: 1.0
initial amount: NaN
is: CHEBI:17490

metaR NADtpu
type: Reaction
name: NAD transporter, peroxisome
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 0 AUTHORS: NOTES:diffusion - but unidirectional uptake into peroxisome (to avoid loops w/ NAD/NADP) NJ
is: SBO:0000185
fast: false
kinetic law: MODEL1310110061#
reactant: MODEL1310110061#
product: MODEL1310110061#
reversible: false
is described by: ECO:0000000

metaR THRCYSNaEx
reactant: MODEL1310110061#
notes: GENE_ASSOCIATION: (6509.1) or (6510.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14530974 NOTES:SAB see Kanai and Hediger 2004 (2003), PMID 14530974
is: SBO:0000185
modifier: MODEL1310110061#
type: Reaction
fast: false
kinetic law: MODEL1310110061#
name: L-cysteine/L-threonine Na-dependent exchange (Thr-L in)
is described by: ECO:0000269
product: MODEL1310110061#
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110061#_7b8c8880_f6f8_496d_957e_4003b38dcb18
has only substance units: false
initial concentration: NaN
constant: false
is encoded by: hsa:10841
initial amount: NaN
type: Species
boundary condition: true
name: FTCD
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110061#_5a1f129b_57bd_45e1_a2e3_8b19f43a8875
constant: false
boundary condition: true
has only substance units: false
is: SBO:0000252
type: Species
is encoded by: hsa:191
initial concentration: NaN
is: B3KUN3
initial amount: NaN
name: AHCY

metaM h r
name: proton
is: http://identifiers.org/pubchem.compound/3380
is: CHEBI:24636
initial concentration: 1.0
type: Species
boundary condition: false
initial amount: NaN
is: SBO:0000247
notes: FORMULA: H CHARGE: 1 INCHI: " HEPATONET_1.0_ABBREVIATION: HC00083 EHMN_ABBREVIATION: C00080
is: C00080
constant: false
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110061#_263a6190_2166_44f5_9c76_c4f6d5ddd871
name: _AI926493_1_m
has only substance units: false
constant: false
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:AI926493
initial amount: NaN
boundary condition: true
type: Species

metaM xoldiolone r
has only substance units: false
is: HMDB02197
is: CHEBI:28477
boundary condition: false
initial amount: NaN
is: SBO:0000247
type: Species
constant: false
initial concentration: 1.0
notes: FORMULA: C27H44O3 CHARGE: 0 INCHI: InChI=1S/C27H44O3/c1-16(2)7-6-8-17(3)20-9-10-21-25-22(15-24(30)27(20,21)5)26(4)12-11-19(28)13-18(26)14-23(25)29/h13,16-17,20-25,29-30H,6-12,14-15H2,1-5H3/t17-,20-,21+,22+,23-,24+,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01465 EHMN_ABBREVIATION: C05457
name: 7alpha,12alpha-Dihydroxycholest-4-en-3-one

metaR r0860
modifier: MODEL1310110061#
kinetic law: MODEL1310110061#
product: MODEL1310110061#
reactant: MODEL1310110061#
type: Reaction
reversible: true
is: SBO:0000185
notes: GENE_ASSOCIATION: (8879.1) SUBSYSTEM: Purine catabolism EC Number: Confidence Level: 0 AUTHORS: PMID:1459,PMID:14598172,PMID:18406340,PMID:8132483 NOTES:
fast: false
name: Utilized transport
is version of: http://identifiers.org/ec-code/4.1.2.27
is described by: ECO:0000000

metaM chsterol l
is: HMDB00067
boundary condition: false
initial amount: NaN
is: SBO:0000247
name: cholesterol
type: Species
notes: FORMULA: C27H46O CHARGE: 0 INCHI: InChI=1S/C27H46O/c1-18(2)7-6-8-19(3)23-11-12-24-22-10-9-20-17-21(28)13-15-26(20,4)25(22)14-16-27(23,24)5/h9,18-19,21-25,28H,6-8,10-17H2,1-5H3/t19-,21+,22+,23-,24+,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00178 EHMN_ABBREVIATION: C00187
has only substance units: false
is: CHEBI:16113
constant: false
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110061#_22a6adf7_5774_40da_95c4_9cf75cb911a9
boundary condition: true
has only substance units: false
is: P49902
initial amount: NaN
type: Species
constant: false
initial concentration: NaN
is: SBO:0000252
name: NT5C2
is encoded by: hsa:22978

metaM nadh x
is: SBO:0000247
name: Nicotinamide adenine dinucleotide - reduced
is: HMDB01487
initial concentration: 1.0
type: Species
constant: false
is: CHEBI:57945
boundary condition: false
is: http://identifiers.org/pubchem.compound/3306
is: C00004
initial amount: NaN
has only substance units: false

metaR r1745
reversible: false
product: MODEL1310110061#
type: Reaction
is: SBO:0000185
reactant: MODEL1310110061#
modifier: MODEL1310110061#
is described by: ECO:0000000
name: Y+LAT2 Utilized transport
fast: false
kinetic law: MODEL1310110061#
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:

metaR r2377
product: MODEL1310110061#
reactant: MODEL1310110061#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:16919238,PMID:17173541,PMID:18406340,PMID:8132483 NOTES:
type: Reaction
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
reversible: true
is: SBO:0000185
fast: false
is described by: ECO:0000000
kinetic law: MODEL1310110061#

metaR r2312
is described by: ECO:0000000
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14579113 NOTES:
reversible: true
fast: false
type: Reaction
kinetic law: MODEL1310110061#
reactant: MODEL1310110061#
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.14
product: MODEL1310110061#

metaM C04853 r
is: CHEBI:57460
initial concentration: 1.0
is: HMDB01509
has only substance units: false
is: SBO:0000247
type: Species
name: 20-hydroxy-leukotriene B4(1-)
constant: false
boundary condition: false
initial amount: NaN
notes: FORMULA: C20H31O5 CHARGE: -1 INCHI: InChI=1S/C20H32O5/c21-17-10-6-2-1-3-7-12-18(22)13-8-4-5-9-14-19(23)15-11-16-20(24)25/h3-5,7-9,13-14,18-19,21-23H,1-2,6,10-12,15-17H2,(H,24,25)/p-1/b5-4+,7-3-,13-8+,14-9-/t18-,19-/m1/s1 EHMN_ABBREVIATION: C04853

http://identifiers.org/biomodels.db/MODEL1310110061#_21308244_1969_4abf_9e6f_bdd4b79ca431
boundary condition: true
has only substance units: false
constant: false
is: SBO:0000252
name: _D29675_1_c
type: Species
initial concentration: NaN
is encoded by: hsa:D29675
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110061#_84e0f48c_bcea_40f4_a2b2_c7e3cf305627
has only substance units: false
is encoded by: hsa:6535
is: B4DIA3
name: SLC6A8
is: SBO:0000252
boundary condition: true
initial concentration: NaN
initial amount: NaN
type: Species
constant: false

metaM 3hmp m
is: SBO:0000247
initial concentration: 1.0
notes: FORMULA: C4H7O3 CHARGE: -1 INCHI: InChI=1S/C4H8O3/c1-3(2-5)4(6)7/h3,5H,2H2,1H3,(H,6,7)/p-1 HEPATONET_1.0_ABBREVIATION: HC00705 EHMN_ABBREVIATION: C01188
constant: false
type: Species
has only substance units: false
is: HMDB00023
initial amount: NaN
is: CHEBI:11805
name: 3-hydroxy-2-methylpropanoate
boundary condition: false

metaR LGNCCOAtx
is described by: ECO:0000000
reversible: true
kinetic law: MODEL1310110061#
product: MODEL1310110061#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: NOTES:interaction between peroxisomes and ER (some enzymes on the outer membrane) NJ
is: SBO:0000185
name: fatty acid intracellular transport
fast: false
reactant: MODEL1310110061#
type: Reaction

metaR ARGtm
fast: false
reactant: MODEL1310110061#
notes: GENE_ASSOCIATION: (83884.1) or (10166.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172 NOTES:TDV
is described by: ECO:0000269
type: Reaction
name: arginine mitochondrial transport via ornithine carrier
modifier: MODEL1310110061#
kinetic law: MODEL1310110061#
is: SBO:0000185
product: MODEL1310110061#
reversible: true

metaM leuktrD4 r
is: HMDB03080
constant: false
has only substance units: false
is: SBO:0000247
is: CHEBI:28666
initial amount: NaN
name: Leukotriene D4
notes: FORMULA: C25H39N2O6S CHARGE: -1 INCHI: InChI=1S/C25H40N2O6S/c1-2-3-4-5-6-7-8-9-10-11-12-13-16-22(21(28)15-14-17-23(29)30)34-19-20(26)25(33)27-18-24(31)32/h6-7,9-13,16,20-22,28H,2-5,8,14-15,17-19,26H2,1H3,(H,27,33)(H,29,30)(H,31,32)/b7-6-,10-9-,12-11+,16-13+/t20-,21-,22+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01664 EHMN_ABBREVIATION: C05951
initial concentration: 1.0
type: Species
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110061#_1d9e0cd2_47b2_4579_baae_164fc561590d
is encoded by: hsa:54576
is: SBO:0000252
initial amount: NaN
name: UGT1A8
boundary condition: true
is: Q5DSZ6
constant: false
type: Species
initial concentration: NaN
has only substance units: false

metaR INSK
is described by: ECO:0000134
fast: false
name: insosine kinase
kinetic law: MODEL1310110061#
reactant: MODEL1310110061#
notes: GENE_ASSOCIATION: SUBSYSTEM: Purine synthesis EC Number: Confidence Level: 4 AUTHORS: NOTES:
reversible: false
product: MODEL1310110061#
is: SBO:0000176
type: Reaction

metaM na1 r
initial concentration: 1.0
boundary condition: false
has only substance units: false
is: HMDB00588
constant: false
is: CHEBI:29101
initial amount: NaN
name: sodium(1+)
type: Species
notes: FORMULA: Na CHARGE: 1 INCHI: InChI=1S/Na/q+1 HEPATONET_1.0_ABBREVIATION: HC00763 EHMN_ABBREVIATION: C01330
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110061#_dced72c0_b275_423d_9676_9fb5f5e426b8
name: AOC2
is encoded by: hsa:314
initial amount: NaN
boundary condition: true
is: O75106
initial concentration: NaN
constant: false
is: SBO:0000252
type: Species
has only substance units: false

metaR PI4PLC
notes: GENE_ASSOCIATION: (23236.1) or (51196.1) or (9651.1) or (113026.1) or (89869.1) or (23007.1) or (5334.1) or (5331.1) or (5333.1) or (257068.1) or (5332.1) or (23236.2) or (5335.1) or (5335.2) or (5336.1) or (5330.1) or (5332.2) or (84812.1) SUBSYSTEM: Inositol phosphate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:10702670,PMID:10702683,PMID:10760467,PMID:11022047,PMID:11022048,PMID:11118617,PMID:12117804,PMID:12213492,PMID:12416999,PMID:13333955,PMID:15140260,PMID:1644792,PMID:2167438,PMID:7607669,PMID:7612006,PMID:7633416,PMID:7789993,PMID:7835906,PMID:7849701,PMID:7890667,PMID:8530101,PMID:9345909 NOTES:NCD
fast: false
reactant: MODEL1310110061#
name: phosphatidylinositol 4-phosphate phospholipase C
product: MODEL1310110061#
kinetic law: MODEL1310110061#
modifier: MODEL1310110061#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.1.4.11
type: Reaction
is described by: ECO:0000269
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110061#_c925ab2b_98b7_4137_a7be_429534964f23
boundary condition: true
constant: false
is: SBO:0000252
initial amount: NaN
name: SHMT1
initial concentration: NaN
type: Species
has only substance units: false
is encoded by: hsa:6470

http://identifiers.org/biomodels.db/MODEL1310110061#_0bb06bc3_2b24_4a21_bfee_1cf0b5d734dd
initial amount: NaN
boundary condition: true
constant: false
has only substance units: false
name: _AI990637_1_x
type: Species
is: SBO:0000252
initial concentration: NaN
is encoded by: hsa:AI990637

metaM abt e
name: L-arabinitol
notes: FORMULA: C5H12O5 CHARGE: 0 INCHI: InChI=1S/C5H12O5/c6-1-3(8)5(10)4(9)2-7/h3-10H,1-2H2/t3-,4-/m0/s1 EHMN_ABBREVIATION: C00532
initial amount: NaN
has only substance units: false
type: Species
boundary condition: false
is: HMDB01851
is: SBO:0000247
initial concentration: 1.0
constant: false
is: CHEBI:18403

metaR r0531
is described by: ECO:0000000
product: MODEL1310110061#
kinetic law: MODEL1310110061#
reactant: MODEL1310110061#
reversible: true
type: Reaction
modifier: MODEL1310110061#
notes: GENE_ASSOCIATION: (3156.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.1.48 Confidence Level: 0 AUTHORS: PMID:11306702,PMID:9923963 NOTES:
name: dUTP:cytidine 5-phosphotransferase Pyrimidine metabolism EC:2.7.1.48
is: SBO:0000176
fast: false
is version of: http://identifiers.org/ec-code/1.1.1.34

metaM chsterol m
is: CHEBI:16113
initial amount: NaN
is: SBO:0000247
initial concentration: 1.0
type: Species
notes: FORMULA: C27H46O CHARGE: 0 INCHI: InChI=1S/C27H46O/c1-18(2)7-6-8-19(3)23-11-12-24-22-10-9-20-17-21(28)13-15-26(20,4)25(22)14-16-27(23,24)5/h9,18-19,21-25,28H,6-8,10-17H2,1-5H3/t19-,21+,22+,23-,24+,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00178 EHMN_ABBREVIATION: C00187
has only substance units: false
is: HMDB00067
boundary condition: false
constant: false
name: cholesterol

http://identifiers.org/biomodels.db/MODEL1310110061#_ed656ed5_28e4_4500_808f_f447bf0747c5
type: Species
constant: false
is: SBO:0000252
has only substance units: false
initial concentration: NaN
boundary condition: true
name: _AI601100_1_m
initial amount: NaN
is encoded by: hsa:AI601100

metaM elaid e
is: CHEBI:30825
is: SBO:0000247
type: Species
constant: false
initial concentration: 1.0
initial amount: NaN
name: elaidate
has only substance units: false
is: HMDB00573
notes: FORMULA: C18H33O2 CHARGE: -1 INCHI: InChI=1S/C18H34O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20/h9-10H,2-8,11-17H2,1H3,(H,19,20)/p-1/b10-9+ HEPATONET_1.0_ABBREVIATION: HC00830
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110061#_91781dfe_7da5_4513_a4cc_084ee21f093f
constant: false
is encoded by: hsa:3074
type: Species
initial amount: NaN
has only substance units: false
name: HEXB
is: SBO:0000252
initial concentration: NaN
is: P07686
boundary condition: true

metaR r2376
is described by: ECO:0000000
kinetic law: MODEL1310110061#
product: MODEL1310110061#
is: SBO:0000185
fast: false
reactant: MODEL1310110061#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:16919238,PMID:17173541,PMID:18406340,PMID:8132483 NOTES:
type: Reaction
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110061#_a9e161d1_f709_4c56_90d3_aa3e971e8ef3
is encoded by: hsa:1340
has only substance units: false
type: Species
initial concentration: NaN
is: P14854
name: COX6B1
constant: false
boundary condition: true
is: SBO:0000252
initial amount: NaN

metaM acald c
initial amount: NaN
type: Species
constant: false
has only substance units: false
name: acetaldehyde
is: CHEBI:15343
initial concentration: 1.0
notes: FORMULA: C2H4O CHARGE: 0 INCHI: InChI=1S/C2H4O/c1-2-3/h2H,1H3 HEPATONET_1.0_ABBREVIATION: HC00087 EHMN_ABBREVIATION: C00084
is: HMDB00990
boundary condition: false
is: SBO:0000247

metaR r2313
reversible: true
type: Reaction
is: SBO:0000185
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
kinetic law: MODEL1310110061#
reactant: MODEL1310110061#
product: MODEL1310110061#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
is described by: ECO:0000000
fast: false

metaR NICRNS
name: NICRNS
kinetic law: MODEL1310110061#
notes: GENE_ASSOCIATION: SUBSYSTEM: NAD metabolism EC Number: Confidence Level: 2 AUTHORS: NOTES:no gene or enzyme name known (in kegg) but reaction has to take place. IT
is described by: ECO:0000000
reversible: false
type: Reaction
product: MODEL1310110061#
fast: false
is: SBO:0000176
reactant: MODEL1310110061#

metaR r0377
name: ATP:deoxycitidine 5-phosphotransferase Pyrimidine metabolism EC:2.7.1.74
modifier: MODEL1310110061#
is: SBO:0000176
is described by: ECO:0000000
kinetic law: MODEL1310110061#
reactant: MODEL1310110061#
fast: false
reversible: false
notes: GENE_ASSOCIATION: (AI653169.1) or (203.1) or (204.1) or (205.1) or (206.1) or (26289.1) or (122481.1) or (AW277253.1) SUBSYSTEM: Pyrimidine catabolism EC Number: 2.7.1.74 Confidence Level: 0 AUTHORS: PMID:12036920,PMID:1657002,PMID:213049,PMID:8399394,PMID:9342341,PMID:9593124 NOTES:
product: MODEL1310110061#
is version of: http://identifiers.org/ec-code/2.7.4.3
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110061#_efb911d1_f73a_4909_b51f_1ea760eac1b4
type: Species
is: SBO:0000252
initial concentration: NaN
name: SLC16A1
boundary condition: true
has only substance units: false
constant: false
initial amount: NaN
is: B4DKS0
is encoded by: hsa:6566

metaM dlnlcg e
is: SBO:0000247
initial concentration: 1.0
constant: false
initial amount: NaN
is: HMDB02925
boundary condition: false
is: CHEBI:53486
name: dihomo-gamma-linolenic acid (n-6)
type: Species
notes: FORMULA: C20H33O2 CHARGE: -1 INCHI: InChI=1S/C20H34O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20(21)22/h6-7,9-10,12-13H,2-5,8,11,14-19H2,1H3,(H,21,22)/b7-6-,10-9-,13-12-
has only substance units: false

metaR PYNP2r
name: pyrimidine-nucleoside phosphorylase (uracil)
type: Reaction
reversible: true
kinetic law: MODEL1310110061#
is described by: ECO:0000269
product: MODEL1310110061#
is version of: http://identifiers.org/ec-code/2.4.2.3
notes: GENE_ASSOCIATION: (7378.2) or (151531.1) or (7378.1) SUBSYSTEM: Pyrimidine catabolism EC Number: 2.4.2.2 Confidence Level: 4 AUTHORS: PMID:11278417,PMID:12084455,PMID:12849978,PMID:7488099 NOTES:JLR- added reversible form of PYNP2
is: SBO:0000176
reactant: MODEL1310110061#
modifier: MODEL1310110061#
fast: false

metaM pail45p hs c
initial amount: NaN
boundary condition: false
constant: false
type: Species
is: CHEBI:28910
name: phosphatidylinositol 4,5-bisphosphate
has only substance units: false
initial concentration: 1.0
notes: FORMULA: C9H14O15P3FULLRCO2FULLR2CO2 CHARGE: -5 EHMN_ABBREVIATION: C04637
is: SBO:0000247

metaR LEUKTRA4t
is: SBO:0000185
reactant: MODEL1310110061#
type: Reaction
is described by: ECO:0000269
reversible: true
fast: false
name: leukotriene A4 transport
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: 1.1.1.27 Confidence Level: 2 AUTHORS: PMID:15987839,PMID:9927705 NOTES:
product: MODEL1310110061#
kinetic law: MODEL1310110061#

http://identifiers.org/biomodels.db/MODEL1310110061#_028700d5_0d1e_42be_981c_2d322499b624
is encoded by: hsa:8398
is: SBO:0000252
initial concentration: NaN
boundary condition: true
type: Species
initial amount: NaN
name: PLA2G6
has only substance units: false
is: O60733
constant: false

metaM air c
initial amount: NaN
is: C03373
type: Species
constant: false
is: CHEBI:58592
is: SBO:0000247
is: HMDB01235
boundary condition: false
notes: FORMULA: C8H12N3O7P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC01108 EHMN_ABBREVIATION: C03373
initial concentration: 1.0
name: 5-amino-1-(5-phospho-D-ribosyl)imidazole
has only substance units: false

metaM HC01376 m
initial concentration: 1.0
type: Species
constant: false
notes: FORMULA: C13H25NO2S2 CHARGE: 0 INCHI: InChI=1S/C13H25NO2S2/c1-3-10(2)13(16)18-9-8-11(17)6-4-5-7-12(14)15/h10-11,17H,3-9H2,1-2H3,(H2,14,15) EHMN_ABBREVIATION: C05118
boundary condition: false
has only substance units: false
is: SBO:0000247
initial amount: NaN
name: S-(2-Methylbutanoyl)-dihydrolipoamide
is: CHEBI:28692

metaM so4 c
name: sulfate
is: CHEBI:16189
notes: FORMULA: O4S CHARGE: -2 INCHI: InChI=1S/H2O4S/c1-5(2,3)4/h(H2,1,2,3,4)/p-2 HEPATONET_1.0_ABBREVIATION: HC00062 EHMN_ABBREVIATION: C00059
constant: false
initial concentration: 1.0
is: HMDB01448
boundary condition: false
is: SBO:0000247
has only substance units: false
initial amount: NaN
type: Species

metaR PRO1xm
product: MODEL1310110061#
fast: false
type: Reaction
kinetic law: MODEL1310110061#
is version of: http://identifiers.org/ec-code/1.5.99.8
is: SBO:0000176
is described by: ECO:0000254
reversible: false
modifier: MODEL1310110061#
name: proline oxidase (NAD), mitochondrial
reactant: MODEL1310110061#
notes: GENE_ASSOCIATION: (5625.1) SUBSYSTEM: Arginine and Proline Metabolism EC Number: Confidence Level: 2 AUTHORS: PMID:10192398 NOTES:NCD

http://identifiers.org/biomodels.db/MODEL1310110061#_fda1ed92_136c_4a3e_921c_d6350f441df8
name: ACSL5
type: Species
is: Q9ULC5
constant: false
is: SBO:0000252
has only substance units: false
boundary condition: true
is encoded by: hsa:51703
initial concentration: NaN
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110061#_803db899_6582_4596_8178_8575c06a0ad3
has part: P23921
type: Species
initial concentration: NaN
boundary condition: true
has part: P31350
has only substance units: false
is encoded by: hsa:6241
is encoded by: hsa:6240
name: RRM1:RRM2
is: SBO:0000297
initial amount: NaN
constant: false

metaM 7dhchsterol c
name: cholesta-5,7-dien-3beta-ol
is: HMDB00032
initial concentration: 1.0
is: CHEBI:17759
has only substance units: false
constant: false
type: Species
notes: FORMULA: C27H44O CHARGE: 0 INCHI: InChI=1S/C27H44O/c1-18(2)7-6-8-19(3)23-11-12-24-22-10-9-20-17-21(28)13-15-26(20,4)25(22)14-16-27(23,24)5/h9-10,18-19,21,23-25,28H,6-8,11-17H2,1-5H3/t19-,21+,23-,24+,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00693 EHMN_ABBREVIATION: C01164
initial amount: NaN
boundary condition: false
is: SBO:0000247

metaR HEX7
is version of: http://identifiers.org/ec-code/2.7.1.2
fast: false
reversible: false
modifier: MODEL1310110061#
is version of: http://identifiers.org/ec-code/2.7.1.1
kinetic law: MODEL1310110061#
notes: GENE_ASSOCIATION: (2645.2) or (2645.3) or (3098.3) or (3098.1) or (3101.1) or (3098.2) or (3099.1) or (2645.1) or (3098.4) or (80201.1) or (3098.5) SUBSYSTEM: Fructose and mannose metabolism EC Number: 2.7.1.1 Confidence Level: 2 AUTHORS: NOTES:D-Glucose, D-mannose, D-fructose, sorbitol and D-glucosamine can act as acceptors; ITP and dATP can act as donors. The liver isoenzyme has sometimes been called glucokinase. Same as 2.7.1.4
product: MODEL1310110061#
type: Reaction
reactant: MODEL1310110061#
is: SBO:0000176
name: hexokinase (D-fructose:ATP)
is described by: ECO:0000304

metaR DHCR72r
modifier: MODEL1310110061#
is: SBO:0000176
type: Reaction
product: MODEL1310110061#
fast: false
name: 7-dehydrocholesterol reductase
reactant: MODEL1310110061#
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (1717.1) SUBSYSTEM: Cholesterol metabolism EC Number: 1.3.1.21 Confidence Level: 4 AUTHORS: PMID:15670717 NOTES:lanosterol -> cholesterol pathway see paper refs Moebius et al PNAS 95:1899-1902 - check/re-check lit for more specific details (NADPH known to be cofactor - also NADH?, possibly rev?) NJ
is version of: http://identifiers.org/ec-code/1.3.1.21
kinetic law: MODEL1310110061#
reversible: false

metaR r2310
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.14
product: MODEL1310110061#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14579113 NOTES:
is described by: ECO:0000000
is: SBO:0000185
kinetic law: MODEL1310110061#
type: Reaction
reversible: true
reactant: MODEL1310110061#

metaR r2375
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:16919238,PMID:17173541,PMID:18406340,PMID:8132483 NOTES:
reactant: MODEL1310110061#
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
type: Reaction
reversible: true
is: SBO:0000185
fast: false
product: MODEL1310110061#
kinetic law: MODEL1310110061#

metaM ribflv c
name: Riboflavin
is: HMDB00244
initial amount: NaN
is: SBO:0000247
is: CHEBI:3554
constant: false
boundary condition: false
type: Species
notes: FORMULA: C17H20N4O6 CHARGE: 0
initial concentration: 1.0
is: C00255
has only substance units: false

metaR ITCOAL1m
reactant: MODEL1310110061#
modifier: MODEL1310110061#
reversible: true
type: Reaction
is version of: http://identifiers.org/ec-code/6.2.1.4
fast: false
name: Itaconate--CoA ligase (GDP-forming), mitochondrial
kinetic law: MODEL1310110061#
product: MODEL1310110061#
is described by: ECO:0000304
notes: GENE_ASSOCIATION: (8802.1 and 8801.1) SUBSYSTEM: C5-branched dibasic acid metabolism EC Number: 6.2.1.4 Confidence Level: 2 AUTHORS: PMID:13783048 NOTES:NCD
is: SBO:0000176

metaR MMSAD1m
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.2.1.27
name: methylmalonate-semialdehyde dehydrogenase
product: MODEL1310110061#
fast: false
kinetic law: MODEL1310110061#
type: Reaction
is described by: ECO:0000269
reversible: false
notes: GENE_ASSOCIATION: (4329.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 1.2.1.27 Confidence Level: 4 AUTHORS: PMID:10947204,PMID:1527093 NOTES:TV Also converts propanal to propanoyl-CoA
modifier: MODEL1310110061#
reactant: MODEL1310110061#

http://identifiers.org/biomodels.db/MODEL1310110061#_08b51350_15f6_4ec6_90ec_388be860d36f
name: _AI631997_1_m
type: Species
is encoded by: hsa:AI631997
boundary condition: true
has only substance units: false
constant: false
initial amount: NaN
initial concentration: NaN
is: SBO:0000252

metaM din e
is: HMDB00071
is: SBO:0000247
is: CHEBI:28997
constant: false
name: Deoxyinosine
has only substance units: false
boundary condition: false
initial concentration: 1.0
notes: FORMULA: C10H12N4O4 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC01493 EHMN_ABBREVIATION: C05512
is: C05512
initial amount: NaN
type: Species

metaM g1p c
is: C00103
type: Species
initial amount: NaN
notes: FORMULA: C6H11O9P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00103 EHMN_ABBREVIATION: C00103
name: D-Glucose 1-phosphate
has only substance units: false
is: HMDB01586
is: SBO:0000247
initial concentration: 1.0
is: CHEBI:58601
constant: false
boundary condition: false

metaR EX dcsptn1 LPAREN e RPAREN
kinetic law: MODEL1310110061#
reactant: MODEL1310110061#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: docosa-4,7,10,13,16-pentaenoic acid (n-6) exchange
type: Reaction

metaM glutcoa m
type: Species
name: glutaryl-CoA(5-)
boundary condition: false
notes: FORMULA: C26H37N7O19P3S CHARGE: -5 INCHI: InChI=1S/C26H42N7O19P3S/c1-26(2,21(39)24(40)29-7-6-15(34)28-8-9-56-17(37)5-3-4-16(35)36)11-49-55(46,47)52-54(44,45)48-10-14-20(51-53(41,42)43)19(38)25(50-14)33-13-32-18-22(27)30-12-31-23(18)33/h12-14,19-21,25,38-39H,3-11H2,1-2H3,(H,28,34)(H,29,40)(H,35,36)(H,44,45)(H,46,47)(H2,27,30,31)(H2,41,42,43)/p-5/t14-,19-,20-,21+,25-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00411 EHMN_ABBREVIATION: C00527
is: HMDB01339
initial amount: NaN
is: CHEBI:57378
has only substance units: false
initial concentration: 1.0
is: SBO:0000247
constant: false

metaR DNDPt28m
name: dCDP transport via dGDP antiport
notes: GENE_ASSOCIATION: (60386.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:11226231 NOTES:IT
product: MODEL1310110061#
type: Reaction
reversible: false
kinetic law: MODEL1310110061#
fast: false
reactant: MODEL1310110061#
is described by: ECO:0000269
modifier: MODEL1310110061#
is: SBO:0000185

metaM prostgi2 c
initial concentration: 1.0
initial amount: NaN
name: prostaglandin I2(1-)
notes: FORMULA: C20H31O5 CHARGE: -1 INCHI: InChI=1S/C20H32O5/c1-2-3-4-7-14(21)10-11-16-17-12-15(8-5-6-9-20(23)24)25-19(17)13-18(16)22/h8,10-11,14,16-19,21-22H,2-7,9,12-13H2,1H3,(H,23,24)/p-1/b11-10+,15-8-/t14-,16+,17+,18+,19-/m0/s1 EHMN_ABBREVIATION: C01312
has only substance units: false
type: Species
is: SBO:0000247
is: CHEBI:57403
is: HMDB01335
boundary condition: false
constant: false

metaR XOL27OHtm
reactant: MODEL1310110061#
name: 27 hydroxy cholesterol transport
is: SBO:0000185
is described by: ECO:0000000
product: MODEL1310110061#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 1 AUTHORS: NOTES:unknown mechanism NJ
fast: false
kinetic law: MODEL1310110061#
reversible: true
type: Reaction

metaM 5thf e
is: HMDB06487
notes: FORMULA: C39H45N11O18 CHARGE: -6
constant: false
initial amount: NaN
type: Species
is: SBO:0000247
has only substance units: false
boundary condition: false
name: pentaglutamyl folate (THF)
initial concentration: 1.0

metaM arachdcoa c
is: HMDB06523
is: SBO:0000247
constant: false
initial concentration: 1.0
is: CHEBI:57368
type: Species
initial amount: NaN
boundary condition: false
notes: FORMULA: C41H62N7O17P3S CHARGE: -4 INCHI: InChI=1S/C41H66N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-32(50)69-25-24-43-31(49)22-23-44-39(53)36(52)41(2,3)27-62-68(59,60)65-67(57,58)61-26-30-35(64-66(54,55)56)34(51)40(63-30)48-29-47-33-37(42)45-28-46-38(33)48/h8-9,11-12,14-15,17-18,28-30,34-36,40,51-52H,4-7,10,13,16,19-27H2,1-3H3,(H,43,49)(H,44,53)(H,57,58)(H,59,60)(H2,42,45,46)(H2,54,55,56)/p-4/b9-8-,12-11-,15-14-,18-17-/t30-,34-,35-,36+,40-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01986 EHMN_ABBREVIATION: C02249
has only substance units: false
name: arachidonoyl-CoA(4-)

metaR FE3MTP1
reversible: false
is described by: ECO:0000134
reactant: MODEL1310110061#
modifier: MODEL1310110061#
kinetic law: MODEL1310110061#
fast: false
product: MODEL1310110061#
type: Reaction
notes: GENE_ASSOCIATION: (30061.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: Sareen S. Gropper, Jack L. Smith, James L. Groff (2009) Advanced nutrition and human metabolism, Wadsworth cengage learning, 5th edition, page 472-476. NOTES:
is: SBO:0000185
name: transport of ferrous iron into blood

metaR NTD11
is described by: ECO:0000269
type: Reaction
is: SBO:0000176
fast: false
modifier: MODEL1310110061#
reactant: MODEL1310110061#
name: 5'-nucleotidase (IMP)
kinetic law: MODEL1310110061#
notes: GENE_ASSOCIATION: (22978.1) or (93034.2) or (93034.1) SUBSYSTEM: Purine catabolism EC Number: 3.1.3.5 Confidence Level: 4 AUTHORS: PMID:11133996 NOTES:Wide specificity for 5'-nucleotides Also see EC 3.1.3.31
product: MODEL1310110061#
is version of: http://identifiers.org/ec-code/3.1.3.5
reversible: false

metaR r2374
product: MODEL1310110061#
kinetic law: MODEL1310110061#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:16919238,PMID:17173541,PMID:18406340,PMID:8132483 NOTES:
is: SBO:0000185
fast: false
reactant: MODEL1310110061#
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
type: Reaction
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110061#_785752a0_6b56_4769_89be_10209ce0e4e9
initial amount: NaN
constant: false
name: CA1
is encoded by: hsa:759
type: Species
initial concentration: NaN
boundary condition: true
is: P00915
has only substance units: false
is: SBO:0000252

metaR r2311
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14579113 NOTES:
kinetic law: MODEL1310110061#
type: Reaction
is: SBO:0000185
reversible: true
reactant: MODEL1310110061#
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.14
product: MODEL1310110061#
is described by: ECO:0000000

metaR HEX10
reversible: false
kinetic law: MODEL1310110061#
is: SBO:0000176
type: Reaction
is described by: ECO:0000212
fast: false
product: MODEL1310110061#
notes: GENE_ASSOCIATION: (2645.1) or (3099.1) or (3098.3) or (2645.2) or (80201.1) or (3098.2) or (2645.3) or (3098.1) or (3098.4) or (3101.1) or (3098.5) SUBSYSTEM: Aminosugar metabolism EC Number: 2.7.1.1 Confidence Level: 1 AUTHORS: NOTES:D-Glucose, D-mannose, D-fructose, sorbitol and D-glucosamine can act as acceptors; ITP and dATP can act as donors. The liver isoenzyme has sometimes been called glucokinase.
reactant: MODEL1310110061#
modifier: MODEL1310110061#
is version of: http://identifiers.org/ec-code/2.7.1.2
name: hexokinase (D-glucosamine:ATP)
is version of: http://identifiers.org/ec-code/2.7.1.1

metaM pyr c
notes: FORMULA: C3H3O3 CHARGE: -1
initial amount: NaN
name: pyruvate
is: CHEBI:15361
has only substance units: false
type: Species
boundary condition: false
initial concentration: 1.0
is: SBO:0000247
is: HMDB00243
constant: false
is: http://identifiers.org/pubchem.compound/3324
is: C00022

metaM dlnlcg c
initial concentration: 1.0
is: SBO:0000247
constant: false
boundary condition: false
initial amount: NaN
name: dihomo-gamma-linolenic acid (n-6)
is: HMDB02925
is: CHEBI:53486
notes: FORMULA: C20H33O2 CHARGE: -1 INCHI: InChI=1S/C20H34O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20(21)22/h6-7,9-10,12-13H,2-5,8,11,14-19H2,1H3,(H,21,22)/b7-6-,10-9-,13-12-
has only substance units: false
type: Species

metaR EHGLAT2m
product: MODEL1310110061#
kinetic law: MODEL1310110061#
is version of: http://identifiers.org/ec-code/2.6.1.1
notes: GENE_ASSOCIATION: (2806.1) SUBSYSTEM: Arginine and Proline Metabolism EC Number: 2.6.1.21 Confidence Level: 2 AUTHORS: PMID:12660328,PMID:15849464 NOTES:NCD SAB oaa -> asp-L
fast: false
name: L-erythro-4-Hydroxyglutamate:2-oxoglutarate aminotransferase 2, mitochondrial
reversible: false
is: SBO:0000176
reactant: MODEL1310110061#
modifier: MODEL1310110061#
type: Reaction
is described by: ECO:0000304

metaM lys L c
boundary condition: false
notes: FORMULA: C6H15N2O2 CHARGE: 1 INCHI: InChI=1S/C6H14N2O2/c7-4-2-1-3-5(8)6(9)10/h5H,1-4,7-8H2,(H,9,10)/p+1/t5-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00053 EHMN_ABBREVIATION: C00047
initial concentration: 1.0
is: HMDB00182
has only substance units: false
is: CHEBI:32551
initial amount: NaN
is: SBO:0000247
name: L-lysinium(1+)
constant: false
type: Species

metaR MTHFCm
notes: GENE_ASSOCIATION: (25902.1) or (10797.1) SUBSYSTEM: Folate metabolism EC Number: 3.5.4.9 Confidence Level: 4 AUTHORS: PMID:12937168 NOTES:NCD
modifier: MODEL1310110061#
is version of: http://identifiers.org/ec-code/6.3.4.3
is described by: ECO:0000269
product: MODEL1310110061#
name: methenyltetrahydrifikate cyclohydrolase, mitochondrial
is: SBO:0000176
reactant: MODEL1310110061#
type: Reaction
reversible: true
kinetic law: MODEL1310110061#
is version of: http://identifiers.org/ec-code/3.5.4.9
fast: false

metaM acald e
has only substance units: false
is: SBO:0000247
type: Species
constant: false
boundary condition: false
is: CHEBI:15343
is: HMDB00990
initial amount: NaN
initial concentration: 1.0
name: acetaldehyde
notes: FORMULA: C2H4O CHARGE: 0 INCHI: InChI=1S/C2H4O/c1-2-3/h2H,1H3 HEPATONET_1.0_ABBREVIATION: HC00087 EHMN_ABBREVIATION: C00084

http://identifiers.org/biomodels.db/MODEL1310110061#_a3da2e01_7714_4e99_8e76_d62450bb0a91
constant: false
initial concentration: NaN
has only substance units: false
boundary condition: true
is: SBO:0000252
type: Species
name: _H77542_1_c
initial amount: NaN
is encoded by: hsa:H77542

http://identifiers.org/biomodels.db/MODEL1310110061#_d56ecd6f_3e42_41ff_b902_4961a2544e5a
boundary condition: true
name: SLC2A10
is: SBO:0000252
initial concentration: NaN
type: Species
constant: false
initial amount: NaN
is encoded by: hsa:81031
is: O95528
has only substance units: false

metaR CYSGLNNaEx
reversible: false
is: SBO:0000185
modifier: MODEL1310110061#
name: L-cysteine/L-glutamine Na-dependent exchange (Cys-L in)
product: MODEL1310110061#
reactant: MODEL1310110061#
notes: GENE_ASSOCIATION: (6510.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14530974 NOTES:SAB see Kanai and Hediger 2004 (2003), PMID 14530974
is described by: ECO:0000269
kinetic law: MODEL1310110061#
type: Reaction
fast: false

metaR FTHFL
type: Reaction
reversible: true
fast: false
notes: GENE_ASSOCIATION: (4522.1) or (286297.1) SUBSYSTEM: Folate metabolism EC Number: Confidence Level: 4 AUTHORS: NOTES:
modifier: MODEL1310110061#
name: Formate-tetrahydrofolate ligase
is version of: http://identifiers.org/ec-code/1.5.1.5
reactant: MODEL1310110061#
is described by: ECO:0000134
kinetic law: MODEL1310110061#
product: MODEL1310110061#
is: SBO:0000176

metaR 2OXOADPTm
kinetic law: MODEL1310110061#
type: Reaction
reversible: true
is: SBO:0000185
notes: GENE_ASSOCIATION: (89874.1) SUBSYSTEM: Tryptophan metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:11083877 NOTES:SAB PMID 11083877
product: MODEL1310110061#
fast: false
modifier: MODEL1310110061#
name: 2-oxoadipate shuttle (cytosol/mitochondria)
is described by: ECO:0000269
reactant: MODEL1310110061#

metaR EX fru LPAREN e RPAREN
kinetic law: MODEL1310110061#
reactant: MODEL1310110061#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for D-Fructose
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110061#_7cfc5dfa_d09e_4461_bacf_e6ccc74c29de
name: SLC25A21
is: G3V4L5
boundary condition: true
is encoded by: hsa:89874
initial amount: NaN
is: SBO:0000252
has only substance units: false
type: Species
constant: false
initial concentration: NaN

metaM so4 e
is: HMDB01448
is: SBO:0000247
type: Species
boundary condition: false
notes: FORMULA: O4S CHARGE: -2 INCHI: InChI=1S/H2O4S/c1-5(2,3)4/h(H2,1,2,3,4)/p-2 HEPATONET_1.0_ABBREVIATION: HC00062 EHMN_ABBREVIATION: C00059
has only substance units: false
initial concentration: 1.0
initial amount: NaN
is: CHEBI:16189
constant: false
name: sulfate

http://identifiers.org/biomodels.db/MODEL1310110061#_5d021c7a_a27a_4421_a20f_0e0acb76530d
initial concentration: NaN
initial amount: NaN
is: SBO:0000252
type: Species
constant: false
is encoded by: hsa:224
boundary condition: true
has only substance units: false
is: P51648
name: ALDH3A2

metaM acac e
is: SBO:0000247
initial amount: NaN
is: CHEBI:13705
name: acetoacetate
is: HMDB00060
constant: false
initial concentration: 1.0
type: Species
notes: FORMULA: C4H5O3 CHARGE: -1 INCHI: InChI=1S/C4H6O3/c1-3(5)2-4(6)7/h2H2,1H3,(H,6,7)/p-1 HEPATONET_1.0_ABBREVIATION: HC00159 EHMN_ABBREVIATION: C00164
has only substance units: false
boundary condition: false

metaR DESAT16 2
fast: false
name: palmitoyl-CoA desaturase (n-C16:0CoA -> n-C16:1CoA)
product: MODEL1310110061#
kinetic law: MODEL1310110061#
is: SBO:0000176
notes: GENE_ASSOCIATION: (6319.1) SUBSYSTEM: Fatty acid synthesis EC Number: 1.14.19.1 Confidence Level: 4 AUTHORS: PMID:14967823 NOTES:for homo sapiens, noted to actually be NADH-cyt b5, using NADH at present NJ
reactant: MODEL1310110061#
type: Reaction
is described by: ECO:0000000
reversible: false
is version of: http://identifiers.org/ec-code/1.14.19.1
modifier: MODEL1310110061#

metaM din c
initial amount: NaN
is: SBO:0000247
is: HMDB00071
boundary condition: false
type: Species
has only substance units: false
initial concentration: 1.0
name: Deoxyinosine
constant: false
is: CHEBI:28997
notes: FORMULA: C10H12N4O4 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC01493 EHMN_ABBREVIATION: C05512
is: C05512

metaR r2316
is described by: ECO:0000000
fast: false
kinetic law: MODEL1310110061#
reversible: true
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
type: Reaction
reactant: MODEL1310110061#
product: MODEL1310110061#
is: SBO:0000185

metaM retn r
name: all-trans-retinoate
initial concentration: 1.0
has only substance units: false
notes: FORMULA: C20H27O2 CHARGE: -1 INCHI: InChI=1S/C20H28O2/c1-15(8-6-9-16(2)14-19(21)22)11-12-18-17(3)10-7-13-20(18,4)5/h6,8-9,11-12,14H,7,10,13H2,1-5H3,(H,21,22)/p-1/b9-6+,12-11+,15-8+,16-14+ HEPATONET_1.0_ABBREVIATION: HC00532 EHMN_ABBREVIATION: C00777
type: Species
is: CHEBI:35291
boundary condition: false
is: SBO:0000247
constant: false
initial amount: NaN
is: HMDB01852

metaR ASPTAm
is version of: http://identifiers.org/ec-code/2.6.1.1
kinetic law: MODEL1310110061#
fast: false
type: Reaction
reversible: true
modifier: MODEL1310110061#
product: MODEL1310110061#
is described by: ECO:0000269
is: SBO:0000176
name: aspartate transaminase
notes: GENE_ASSOCIATION: (2806.1) SUBSYSTEM: Alanine and aspartate metabolism EC Number: 2.6.1.1 Confidence Level: 4 AUTHORS: PMID:6930651 NOTES:NCD
reactant: MODEL1310110061#

metaM duri c
is: C00526
is: SBO:0000247
is: CHEBI:16450
initial concentration: 1.0
name: Deoxyuridine
boundary condition: false
initial amount: NaN
is: HMDB00012
notes: FORMULA: C9H12N2O5 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00410 EHMN_ABBREVIATION: C00526
constant: false
type: Species
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110061#_f79e2ff3_ac3d_4a77_8494_40da2b75226f
has only substance units: false
initial amount: NaN
type: Species
is: O14521
initial concentration: NaN
boundary condition: true
is: SBO:0000252
is encoded by: hsa:6392
constant: false
name: SDHD

metaM ribflv e
has only substance units: false
is: HMDB00244
type: Species
name: Riboflavin
constant: false
is: SBO:0000247
is: CHEBI:3554
notes: FORMULA: C17H20N4O6 CHARGE: 0
boundary condition: false
is: C00255
initial concentration: 1.0
initial amount: NaN

metaR DGCHOLte
type: Reaction
is described by: ECO:0000000
name: bile acid intracellular transport
is: SBO:0000185
kinetic law: MODEL1310110061#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 1 AUTHORS: NOTES:unknown mechanism, however bile acids need to be secreted out of the cell NJ
reversible: true
reactant: MODEL1310110061#
fast: false
product: MODEL1310110061#

metaR r2102
modifier: MODEL1310110061#
kinetic law: MODEL1310110061#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
reversible: true
is: SBO:0000185
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
reactant: MODEL1310110061#
product: MODEL1310110061#
is described by: ECO:0000000
type: Reaction
fast: false

metaM 4ppan c
is: C03492
is: HMDB01016
constant: false
name: D-4'-Phosphopantothenate
notes: FORMULA: C9H15NO8P CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC01127 EHMN_ABBREVIATION: C03492
is: SBO:0000247
is: CHEBI:10986
initial amount: NaN
type: Species
initial concentration: 1.0
has only substance units: false
boundary condition: false

metaR ADSL1
kinetic law: MODEL1310110061#
fast: false
reversible: false
is version of: http://identifiers.org/ec-code/4.3.2.2
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (158.1) or (158.2) SUBSYSTEM: Nucleotide interconversion EC Number: 4.3.2.2 Confidence Level: 4 AUTHORS: PMID:1302001,PMID:2004782 NOTES:
is: SBO:0000176
product: MODEL1310110061#
reactant: MODEL1310110061#
modifier: MODEL1310110061#
name: adenylosuccinate lyase
type: Reaction

metaR DCSPTN1COAtx
reactant: MODEL1310110061#
type: Reaction
product: MODEL1310110061#
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: NOTES:interaction between peroxisomes and ER (some enzymes on the outer membrane) NJ
name: fatty acid intracellular transport
kinetic law: MODEL1310110061#
is: SBO:0000185
is described by: ECO:0000000
fast: false

metaR GTHPm
modifier: MODEL1310110061#
is version of: http://identifiers.org/ec-code/1.11.1.15
kinetic law: MODEL1310110061#
is: SBO:0000176
name: glutathione peroxidase, mitochondria
notes: GENE_ASSOCIATION: (10935.1) or (10935.2) or (2879.1) SUBSYSTEM: Glutathione metabolism EC Number: 1.11.1.9 Confidence Level: 4 AUTHORS: PMID:12427732 NOTES:TV (8-15-2003)
reactant: MODEL1310110061#
fast: false
product: MODEL1310110061#
type: Reaction
is version of: http://identifiers.org/ec-code/1.11.1.12
reversible: true
is described by: ECO:0000269

metaM dhea r
has only substance units: false
is: CHEBI:28689
initial amount: NaN
type: Species
constant: false
boundary condition: false
initial concentration: 1.0
name: 3beta-hydroxyandrost-5-en-17-one
notes: FORMULA: C19H28O2 CHARGE: 0 INCHI: InChI=1S/C19H28O2/c1-18-9-7-13(20)11-12(18)3-4-14-15-5-6-17(21)19(15,2)10-8-16(14)18/h3,13-16,20H,4-11H2,1-2H3/t13-,14-,15-,16-,18-,19-/m0/s1 EHMN_ABBREVIATION: C01227
is: HMDB00077
is: SBO:0000247

metaR RE3556C
is: SBO:0000176
reactant: MODEL1310110061#
reversible: true
is described by: ECO:0000000
product: MODEL1310110061#
fast: false
type: Reaction
name: RE3556
notes: GENE_ASSOCIATION: SUBSYSTEM: Eicosanoid metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:234423 NOTES:
kinetic law: MODEL1310110061#

metaR EX 5mta LPAREN e RPAREN
kinetic law: MODEL1310110061#
reactant: MODEL1310110061#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: Exchange of 5-S-methyl-5-thioadenosine
type: Reaction

metaR EX pro L LPAREN e RPAREN
kinetic law: MODEL1310110061#
reactant: MODEL1310110061#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: L-Proline exchange
type: Reaction

metaR CERK
is version of: http://identifiers.org/ec-code/2.7.1.138
notes: GENE_ASSOCIATION: (64781.1) or (64781.2) SUBSYSTEM: Sphingolipid metabolism EC Number: 2.7.1.138 Confidence Level: 4 AUTHORS: PMID:11956206 NOTES:NJ
modifier: MODEL1310110061#
reversible: false
reactant: MODEL1310110061#
name: Ceramide kinase
type: Reaction
product: MODEL1310110061#
is: SBO:0000176
kinetic law: MODEL1310110061#
is described by: ECO:0000269
fast: false

metaM tre e
notes: FORMULA: C12H22O11 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00658 EHMN_ABBREVIATION: C01083
is: HMDB00975
has only substance units: false
boundary condition: false
is: C01083
constant: false
is: SBO:0000247
is: CHEBI:16551
initial amount: NaN
type: Species
name: Trehalose
initial concentration: 1.0

metaM CE5117 m
type: Species
constant: false
is: CHEBI:57923
name: (3E,5Z,8Z)-tetradecatrienoyl-CoA
has only substance units: false
boundary condition: false
initial concentration: 1.0
initial amount: NaN
notes: FORMULA: C35H52N7O17P3S CHARGE: -4 INCHI: InChI=1/C35H56N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-26(44)63-19-18-37-25(43)16-17-38-33(47)30(46)35(2,3)21-56-62(53,54)59-61(51,52)55-20-24-29(58-60(48,49)50)28(45)34(57-24)42-23-41-27-31(36)39-22-40-32(27)42/h8-9,11-14,22-24,28-30,34,45-46H,4-7,10,15-21H2,1-3H3,(H,37,43)(H,38,47)(H,51,52)(H,53,54)(H2,36,39,40)(H2,48,49,50)/p-4/b9-8-,12-11-,14-13+/t24-,28+,29+,30u,34-/m0/s1 EHMN_ABBREVIATION: CE5117
is: SBO:0000247

metaR T4HCINNMFM
notes: GENE_ASSOCIATION: SUBSYSTEM: Ubiquinone synthesis EC Number: Confidence Level: 2 AUTHORS: PMID:11583838,PMID:12232327 NOTES:IT reaction involved in formation of 4-hydroxybenzoate from tyrosine.
type: Reaction
product: MODEL1310110061#
kinetic law: MODEL1310110061#
reversible: false
fast: false
reactant: MODEL1310110061#
is: SBO:0000176
is described by: ECO:0000000
name: 4-hydroxycinnamate formation

http://identifiers.org/biomodels.db/MODEL1310110061#_cf3c2240_44fc_4eeb_8f22_51a9e618f981
constant: false
boundary condition: true
has only substance units: false
is encoded by: hsa:6319
is: O00767
type: Species
initial amount: NaN
name: SCD
is: SBO:0000252
initial concentration: NaN

metaM glyc R m
has only substance units: false
is: HMDB00139
name: D-glycerate
is: CHEBI:16659
initial concentration: 1.0
is: SBO:0000247
constant: false
boundary condition: false
notes: FORMULA: C3H5O4 CHARGE: -1 INCHI: InChI=1S/C3H6O4/c4-1-2(5)3(6)7/h2,4-5H,1H2,(H,6,7)/p-1/t2-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00235
initial amount: NaN
type: Species

http://identifiers.org/biomodels.db/MODEL1310110061#_7beb4e54_fc99_42e3_a24a_ad3e072fb2e8
initial amount: NaN
constant: false
is encoded by: hsa:AI926493
boundary condition: true
initial concentration: NaN
type: Species
is: SBO:0000252
name: _AI926493_1_c
has only substance units: false

metaM pac c
notes: FORMULA: C8H7O2 CHARGE: -1 INCHI: InChI=1S/C8H8O2/c9-8(10)6-7-4-2-1-3-5-7/h1-5H,6H2,(H,9,10)/p-1 HEPATONET_1.0_ABBREVIATION: HC01781 EHMN_ABBREVIATION: C07086
initial amount: NaN
initial concentration: 1.0
boundary condition: false
has only substance units: false
is: SBO:0000247
name: phenylacetate
type: Species
constant: false
is: HMDB00209
is: CHEBI:18401

http://identifiers.org/biomodels.db/MODEL1310110061#_8a9bb1dc_9675_4fba_9208_4a7ab9ecfbfb
type: Species
has only substance units: false
initial amount: NaN
boundary condition: true
is: SBO:0000252
is: P49327
initial concentration: NaN
is encoded by: hsa:2194
constant: false
name: FASN

metaR ATPtm
is: SBO:0000185
product: MODEL1310110061#
modifier: MODEL1310110061#
reversible: false
is described by: ECO:0000269
type: Reaction
reactant: MODEL1310110061#
kinetic law: MODEL1310110061#
name: ADP/ATP transporter, mitochondrial
notes: GENE_ASSOCIATION: (291.1) or (293.1) or (292.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172 NOTES:NCD
fast: false

metaM CE2434 m
notes: FORMULA: C39H60N7O17P3S CHARGE: -4 INCHI: InChI=1/C39H64N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-30(48)67-23-22-41-29(47)20-21-42-37(51)34(50)39(2,3)25-60-66(57,58)63-65(55,56)59-24-28-33(62-64(52,53)54)32(49)38(61-28)46-27-45-31-35(40)43-26-44-36(31)46/h8-9,11-12,18-19,26-28,32-34,38,49-50H,4-7,10,13-17,20-25H2,1-3H3,(H,41,47)(H,42,51)(H,55,56)(H,57,58)(H2,40,43,44)(H2,52,53,54)/p-4/b9-8-,12-11-,19-18+/t28-,32+,33+,34u,38-/m0/s1 EHMN_ABBREVIATION: CE2434
is: SBO:0000247
constant: false
type: Species
initial concentration: 1.0
name: trans,cis,cis-2,9,12-octadecatrienoyl-CoA
boundary condition: false
has only substance units: false
initial amount: NaN
is: CHEBI:57795

metaR r2317
type: Reaction
fast: false
reactant: MODEL1310110061#
product: MODEL1310110061#
is described by: ECO:0000000
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
kinetic law: MODEL1310110061#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
reversible: true
is: SBO:0000185

metaR HEX4
fast: false
is version of: http://identifiers.org/ec-code/2.7.1.2
kinetic law: MODEL1310110061#
modifier: MODEL1310110061#
is version of: http://identifiers.org/ec-code/2.7.1.1
reversible: false
name: hexokinase (D-mannose:ATP)
type: Reaction
product: MODEL1310110061#
is: SBO:0000176
notes: GENE_ASSOCIATION: (3098.2) or (2645.2) or (3098.3) or (2645.3) or (3098.4) or (3099.1) or (3098.5) or (3098.1) or (3101.1) or (80201.1) or (2645.1) SUBSYSTEM: Fructose and mannose metabolism EC Number: 2.7.1.7 Confidence Level: 2 AUTHORS: NOTES:D-Glucose, D-mannose, D-fructose, sorbitol and D-glucosamine can act as acceptors; ITP and dATP can act as donors. The liver isoenzyme has sometimes been called glucokinase. also active in ecoli PMID: 4557975
is described by: ECO:0000304
reactant: MODEL1310110061#

metaM pyr e
initial amount: NaN
name: pyruvate
type: Species
is: CHEBI:15361
is: HMDB00243
has only substance units: false
notes: FORMULA: C3H3O3 CHARGE: -1 INCHI: InChI=1S/C3H4O3/c1-2(4)3(5)6/h1H3,(H,5,6)/p-1 HEPATONET_1.0_ABBREVIATION: HC00032 EHMN_ABBREVIATION: C00022
constant: false
is: SBO:0000247
boundary condition: false
initial concentration: 1.0

metaR r2103
is: SBO:0000185
fast: false
reversible: true
modifier: MODEL1310110061#
kinetic law: MODEL1310110061#
product: MODEL1310110061#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
reactant: MODEL1310110061#
is described by: ECO:0000000
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110061#_5d85867b_dba6_456e_982c_2dea7e8bfb2a
initial concentration: NaN
type: Species
name: _C7orf24_1_m
is: SBO:0000252
initial amount: NaN
has only substance units: false
constant: false
is encoded by: hsa:C7orf24
boundary condition: true

metaR r1812
modifier: MODEL1310110061#
type: Reaction
product: MODEL1310110061#
name: Y+LAT2 Utilized transport
is: SBO:0000185
kinetic law: MODEL1310110061#
fast: false
is described by: ECO:0000000
reversible: false
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reactant: MODEL1310110061#

metaM n2m2nmasn l
boundary condition: false
initial concentration: 1.0
has only substance units: false
type: Species
is: SBO:0000247
name: N-Acetyl-beta-D-glucosaminyl-1,2-alpha-D-mannosyl-1,3-(N-acetyl-beta-D-glucosaminyl-1,2-alpha-D-mannosyl-1,6)-(N-acetyl-beta-D-glucosaminyl-1,4)-beta-D-mannosyl-1,4-N-acetyl-beta-D-glucosaminyl-R
is: C04946
constant: false
initial amount: NaN
notes: FORMULA: C58H96N5O40X CHARGE: 0

metaR ADSL2
product: MODEL1310110061#
is described by: ECO:0000269
reversible: false
name: adenylosuccinate lyase
notes: GENE_ASSOCIATION: (158.1) or (158.2) SUBSYSTEM: Purine synthesis EC Number: 4.3.2.2 Confidence Level: 4 AUTHORS: PMID:1302001,PMID:2004782 NOTES:
kinetic law: MODEL1310110061#
is version of: http://identifiers.org/ec-code/4.3.2.2
modifier: MODEL1310110061#
is: SBO:0000176
fast: false
reactant: MODEL1310110061#
type: Reaction

metaR NP1
notes: GENE_ASSOCIATION: (4860.1) SUBSYSTEM: NAD metabolism EC Number: 3.4.2.1 Confidence Level: 2 AUTHORS: NOTES:NCD
kinetic law: MODEL1310110061#
name: nucleotide phosphatase
fast: false
is described by: ECO:0000304
is: SBO:0000176
product: MODEL1310110061#
reversible: false
is version of: http://identifiers.org/ec-code/2.4.2.1
modifier: MODEL1310110061#
reactant: MODEL1310110061#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110061#_e167d50e_3fec_440d_922f_beb2a7ed8b34
initial amount: NaN
has only substance units: false
is: SBO:0000252
is: Q9UN76
boundary condition: true
is encoded by: hsa:11254
name: SLC6A14
initial concentration: NaN
type: Species
constant: false

metaM btamp c
constant: false
name: Biotinyl-5'-AMP
initial concentration: 1.0
initial amount: NaN
is: HMDB04220
is: CHEBI:3110
boundary condition: false
type: Species
is: SBO:0000247
has only substance units: false
notes: FORMULA: C20H27N7O9PS CHARGE: -1 INCHI: InChI=1S/C20H28N7O9PS/c21-17-14-18(23-7-22-17)27(8-24-14)19-16(30)15(29)10(35-19)5-34-37(32,33)36-12(28)4-2-1-3-11-13-9(6-38-11)25-20(31)26-13/h7-11,13,15-16,19,29-30H,1-6H2,(H,32,33)(H2,21,22,23)(H2,25,26,31)/t9-,10+,11-,13-,15+,16+,19+/m0/s1 EHMN_ABBREVIATION: C05921

metaR CDS
reactant: MODEL1310110061#
type: Reaction
kinetic law: MODEL1310110061#
is version of: http://identifiers.org/ec-code/2.7.7.41
is: SBO:0000176
modifier: MODEL1310110061#
is described by: ECO:0000000
name: phosphatidate cytidylyltransferase
reversible: false
fast: false
product: MODEL1310110061#
notes: GENE_ASSOCIATION: (1040.1) SUBSYSTEM: Glycerophospholipid metabolism EC Number: 2.7.7.41 Confidence Level: 4 AUTHORS: NOTES:ER membrane - but on cytosolic surface NJ

metaR 5MTHFt
product: MODEL1310110061#
notes: GENE_ASSOCIATION: (2348.5) or (2348.3) or (2348.1) or (2348.6) or (2352.1) or (2348.4) or (2348.2) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:15094208 NOTES:IT
fast: false
type: Reaction
reversible: true
name: 5-Methyltetrahydrofolate transport via receptor binding and protolysis
kinetic law: MODEL1310110061#
is: SBO:0000185
is described by: ECO:0000269
modifier: MODEL1310110061#
reactant: MODEL1310110061#

http://identifiers.org/biomodels.db/MODEL1310110061#_ae01ffb8_7b20_4e54_b4ba_bb30b5f6031a
type: Species
is encoded by: hsa:HG2846-HT2983
has only substance units: false
initial concentration: NaN
constant: false
boundary condition: true
name: _HG2846_HT2983_1_c
initial amount: NaN
is: SBO:0000252

metaM duri e
is: HMDB00012
name: Deoxyuridine
notes: FORMULA: C9H12N2O5 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00410 EHMN_ABBREVIATION: C00526
type: Species
is: C00526
is: SBO:0000247
initial amount: NaN
initial concentration: 1.0
has only substance units: false
boundary condition: false
is: CHEBI:16450
constant: false

metaM dgmp e
type: Species
is: CHEBI:57673
initial concentration: 1.0
boundary condition: false
name: dGMP(2-)
constant: false
has only substance units: false
initial amount: NaN
is: HMDB01044
notes: FORMULA: C10H12N5O7P CHARGE: -2 INCHI: InChI=1S/C10H14N5O7P/c11-10-13-8-7(9(17)14-10)12-3-15(8)6-1-4(16)5(22-6)2-21-23(18,19)20/h3-6,16H,1-2H2,(H2,18,19,20)(H3,11,13,14,17)/p-2/t4-,5+,6+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00306 EHMN_ABBREVIATION: C00362
is: SBO:0000247

metaM HC02216 c
initial amount: NaN
is: CHEBI:28922
type: Species
has only substance units: false
initial concentration: 1.0
boundary condition: false
notes: FORMULA: C20H33O5 CHARGE: -1 INCHI: InChI=1S/C20H34O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h4,7,12-13,15-19,21-23H,2-3,5-6,8-11,14H2,1H3,(H,24,25)/b7-4-,13-12+/t15-,16+,17+,18+,19+/m0/s1
constant: false
name: prostaglandin-f2beta
is: SBO:0000247

metaR GGH 10FTHF6GLUe
fast: false
modifier: MODEL1310110061#
is: SBO:0000176
name: Gamma-glutamyl hydrolase (10FTHF6GLU), extracellular
product: MODEL1310110061#
is described by: ECO:0000000
kinetic law: MODEL1310110061#
type: Reaction
is version of: http://identifiers.org/ec-code/3.4.19.9
notes: GENE_ASSOCIATION: (8836.1) SUBSYSTEM: Folate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:11375437,PMID:2867095,PMID:9614206 NOTES:REMOVES EITHER ONE OR TWO GLUTAMYL RESIDUES WITH A REACTION (WILL ONLY REPRESENT 1) IT
reactant: MODEL1310110061#
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110061#_3baf4dfb_41ab_49c4_b6b4_1ac4ef51234f
boundary condition: true
is: Q96SL4
type: Species
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:2882
constant: false
is: SBO:0000252
has only substance units: false
name: GPX7

metaR ADMDC
name: adenosylmethionine decarboxylase
is: SBO:0000176
notes: GENE_ASSOCIATION: (262.1) SUBSYSTEM: Arginine and Proline Metabolism EC Number: 4.1.1.50 Confidence Level: 4 AUTHORS: PMID:2460457 NOTES:
is version of: http://identifiers.org/ec-code/4.1.1.50
modifier: MODEL1310110061#
is described by: ECO:0000269
product: MODEL1310110061#
type: Reaction
reversible: false
kinetic law: MODEL1310110061#
fast: false
reactant: MODEL1310110061#

metaR r2379
kinetic law: MODEL1310110061#
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
fast: false
reversible: true
reactant: MODEL1310110061#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:16919238,PMID:17173541,PMID:18406340,PMID:8132483 NOTES:
is: SBO:0000185
product: MODEL1310110061#
is described by: ECO:0000000

metaR r2100
type: Reaction
fast: false
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
kinetic law: MODEL1310110061#
reversible: true
is: SBO:0000185
product: MODEL1310110061#
reactant: MODEL1310110061#
modifier: MODEL1310110061#
is described by: ECO:0000000

metaR r2314
is: SBO:0000185
product: MODEL1310110061#
is described by: ECO:0000000
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
fast: false
reversible: true
type: Reaction
reactant: MODEL1310110061#
kinetic law: MODEL1310110061#

metaM nadh r
has only substance units: false
type: Species
initial amount: NaN
is: CHEBI:57945
constant: false
is: HMDB01487
initial concentration: 1.0
boundary condition: false
is: SBO:0000247
notes: FORMULA: C21H27N7O14P2 CHARGE: -2 INCHI: InChI=1S/C21H29N7O14P2/c22-17-12-19(25-7-24-17)28(8-26-12)21-16(32)14(30)11(41-21)6-39-44(36,37)42-43(34,35)38-5-10-13(29)15(31)20(40-10)27-3-1-2-9(4-27)18(23)33/h1,3-4,7-8,10-11,13-16,20-21,29-32H,2,5-6H2,(H2,23,33)(H,34,35)(H,36,37)(H2,22,24,25)/p-2/t10-,11-,13-,14-,15-,16-,20-,21-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00014 EHMN_ABBREVIATION: C00004
name: NADH(2-)

metaR EX itp LPAREN e RPAREN
kinetic law: MODEL1310110061#
reactant: MODEL1310110061#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of ITP(3-)
type: Reaction

metaM 2mbcoa m
name: 2-methylbutanoyl-CoA(4-)
is: SBO:0000247
has only substance units: false
is: CHEBI:57336
initial concentration: 1.0
type: Species
is: HMDB01041
constant: false
initial amount: NaN
notes: FORMULA: C26H40N7O17P3S CHARGE: -4 INCHI: InChI=1S/C26H44N7O17P3S/c1-5-14(2)25(38)54-9-8-28-16(34)6-7-29-23(37)20(36)26(3,4)11-47-53(44,45)50-52(42,43)46-10-15-19(49-51(39,40)41)18(35)24(48-15)33-13-32-17-21(27)30-12-31-22(17)33/h12-15,18-20,24,35-36H,5-11H2,1-4H3,(H,28,34)(H,29,37)(H,42,43)(H,44,45)(H2,27,30,31)(H2,39,40,41)/p-4/t14?,15-,18-,19-,20+,24-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00632 EHMN_ABBREVIATION: C01033
boundary condition: false

metaM 3dphb m
boundary condition: false
initial amount: NaN
type: Species
initial concentration: 1.0
is: SBO:0000247
has only substance units: false
is: HMDB06251
constant: false
notes: FORMULA: C57H85O3 CHARGE: -1 INCHI: InChI=1/C57H86O3/c1-44(2)21-12-22-45(3)23-13-24-46(4)25-14-26-47(5)27-15-28-48(6)29-16-30-49(7)31-17-32-50(8)33-18-34-51(9)35-19-36-52(10)37-20-38-53(11)39-40-54-43-55(57(59)60)41-42-56(54)58/h21,23,25,27,29,31,33,35,37,39,41-43,58H,12-20,22,24,26,28,30,32,34,36,38,40H2,1-11H3,(H,59,60)/b45-23+,46-25+,47-27+,48-29+,49-31+,50-33+,51-35+,52-37+,53-39+
name: 3-Decaprenyl-4-hydroxybenzoate

metaM CE5236 n
initial concentration: 1.0
constant: false
type: Species
notes: FORMULA: C9H13N5O3 CHARGE: 0 INCHI: InChI=1/C9H13N5O3/c1-3-5(15)4-2-11-6-9(14-4,17-3)7(16)13-8(10)12-6/h3-5,14-15H,2H2,1H3,(H3,10,11,12,13,16)/p+1/t3-,4u,5+,9u/m0/s1 EHMN_ABBREVIATION: CE5236
is: SBO:0000247
name: O2'-4a-cyclic-tetrahydrobiopterin
boundary condition: false
initial amount: NaN
is: HMDB03952
has only substance units: false
is: CHEBI:28002

metaM abt c
is: CHEBI:18403
name: L-arabinitol
is: SBO:0000247
type: Species
initial amount: NaN
is: HMDB01851
notes: FORMULA: C5H12O5 CHARGE: 0 INCHI: InChI=1S/C5H12O5/c6-1-3(8)5(10)4(9)2-7/h3-10H,1-2H2/t3-,4-/m0/s1 EHMN_ABBREVIATION: C00532
constant: false
initial concentration: 1.0
has only substance units: false
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110061#_e722f5ae_32a6_41e4_8cd1_db39214f4fd5
has only substance units: false
boundary condition: true
is: O75038
constant: false
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:9651
type: Species
is: SBO:0000252
name: PLCH2

metaM etfox m
is: SBO:0000247
type: Species
notes: FORMULA: R CHARGE: 0
constant: false
is: HMDB00145
name: Electron transfer flavoprotein oxidized
boundary condition: false
initial concentration: 1.0
is: CHEBI:17263
has only substance units: false
initial amount: NaN

metaR B MANNASEly
is version of: http://identifiers.org/ec-code/3.2.1.25
type: Reaction
product: MODEL1310110061#
is described by: ECO:0000000
name: beta-mannosidase, lysosomal
kinetic law: MODEL1310110061#
reactant: MODEL1310110061#
notes: GENE_ASSOCIATION: (4126.1) SUBSYSTEM: N-glycan degradation EC Number: 3.2.1.25 Confidence Level: 0 AUTHORS: PMID:9384606 NOTES:NCD
modifier: MODEL1310110061#
reversible: false
fast: false
is: SBO:0000176

metaR FAOXC123C102m
kinetic law: MODEL1310110061#
product: MODEL1310110061#
reactant: MODEL1310110061#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C12:3-->C10:2)m
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110061#_055bfa1d_c569_4526_b4cf_65d4a6243e46
initial amount: NaN
type: Species
constant: false
is encoded by: hsa:2618
is: SBO:0000252
has only substance units: false
initial concentration: NaN
is: P22102
name: GART
boundary condition: true

metaR EX chsterol LPAREN e RPAREN
kinetic law: MODEL1310110061#
reactant: MODEL1310110061#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for cholesterol
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110061#_bc689e47_7fbe_409b_b8bc_209ecf6dd041
constant: false
is encoded by: hsa:6120
has only substance units: false
name: RPE
initial amount: NaN
is: SBO:0000252
type: Species
initial concentration: NaN
is: Q53TV9
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110061#_ed6944cd_69f5_4b9c_8e97_8a781b97f885
boundary condition: true
has only substance units: false
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:5805
type: Species
constant: false
name: PTS
is: Q03393
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110061#_374b7e56_67b6_4151_afb4_11aa94e8f76e
is: SBO:0000297
is encoded by: hsa:9517
has part: O15269
boundary condition: true
type: Species
name: SPTLC1:SPTLC2
constant: false
is encoded by: hsa:10558
has only substance units: false
initial amount: NaN
has part: O15270
initial concentration: NaN

metaR GLYSNAT5tc
kinetic law: MODEL1310110061#
product: MODEL1310110061#
reactant: MODEL1310110061#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: transport of Glycine into the cell coupled with co-transport with Sodium and counter transport with proton by SNAT5 transporter.
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110061#_651b7675_645a_46f7_b799_de7813129b2c
initial concentration: NaN
boundary condition: true
is encoded by: hsa:9123
name: SLC16A3
type: Species
constant: false
has only substance units: false
is: O15427
initial amount: NaN
is: SBO:0000252

metaR r2315
is: SBO:0000185
reversible: true
type: Reaction
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
reactant: MODEL1310110061#
kinetic law: MODEL1310110061#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
product: MODEL1310110061#
fast: false
is described by: ECO:0000000

metaR r2378
product: MODEL1310110061#
is described by: ECO:0000000
is: SBO:0000185
kinetic law: MODEL1310110061#
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
reversible: true
reactant: MODEL1310110061#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:16919238,PMID:17173541,PMID:18406340,PMID:8132483 NOTES:
fast: false

metaR GLCtg
reversible: true
notes: GENE_ASSOCIATION: (6513.1) SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 4 AUTHORS: PMID:15384581 NOTES:NCD
modifier: MODEL1310110061#
product: MODEL1310110061#
fast: false
name: glucose transport, Golgi apparatus
type: Reaction
reactant: MODEL1310110061#
is described by: ECO:0000269
kinetic law: MODEL1310110061#
is: SBO:0000185

metaR r2101
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
is described by: ECO:0000000
type: Reaction
is: SBO:0000185
kinetic law: MODEL1310110061#
reversible: true
fast: false
modifier: MODEL1310110061#
reactant: MODEL1310110061#
product: MODEL1310110061#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110061#_5245816c_df38_495c_80b1_7dbf99b9b444
name: SLC7A9
type: Species
is encoded by: hsa:11136
initial amount: NaN
boundary condition: true
has only substance units: false
is: P82251
constant: false
is: SBO:0000252
initial concentration: NaN

metaM tettet6 c
notes: FORMULA: C24H39O2 CHARGE: -1 INCHI: InChI=1/C24H40O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-24(25)26/h16-23H,2-15H2,1H3,(H,25,26)/b17-16+,19-18+,21-20+,23-22+
initial amount: NaN
type: Species
is: SBO:0000247
name: tetracosatetraenoic acid n-6
is: HMDB06246
constant: false
boundary condition: false
has only substance units: false
initial concentration: 1.0

metaM mi4p D c
name: 1D-myo-inositol 4-phosphate(2-)
is: HMDB01313
is: CHEBI:58469
type: Species
notes: FORMULA: C6H11O9P CHARGE: -2 INCHI: InChI=1S/C6H13O9P/c7-1-2(8)4(10)6(5(11)3(1)9)15-16(12,13)14/h1-11H,(H2,12,13,14)/p-2/t1-,2-,3-,4+,5-,6-/m0/s1
has only substance units: false
constant: false
initial concentration: 1.0
is: SBO:0000247
initial amount: NaN
boundary condition: false

metaM elaid c
initial concentration: 1.0
is: SBO:0000247
name: elaidate
constant: false
type: Species
boundary condition: false
has only substance units: false
notes: FORMULA: C18H33O2 CHARGE: -1 INCHI: InChI=1S/C18H34O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20/h9-10H,2-8,11-17H2,1H3,(H,19,20)/p-1/b10-9+ HEPATONET_1.0_ABBREVIATION: HC00830
initial amount: NaN
is: HMDB00573
is: CHEBI:30825

metaR TXA2tr
type: Reaction
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: NOTES:unknown mechanism for transport - known to be secreted from cells - unknown mechanism or pathway, TXA2tr -> TXA2te to get to EC space NJ
kinetic law: MODEL1310110061#
is described by: ECO:0000000
name: thromboxane A2 intracellular transport
product: MODEL1310110061#
reversible: true
reactant: MODEL1310110061#
is: SBO:0000185

metaR PUNP1
reversible: true
notes: GENE_ASSOCIATION: (4860.1) SUBSYSTEM: Nucleotide interconversion EC Number: 3.4.2.1 Confidence Level: 4 AUTHORS: PMID:6087295,PMID:9305963 NOTES:Specificity not completely determined. Can also catalyse ribosyltransferase reactions of the type catalysed by EC 2.4.2.5, nucleoside ribosyltransferase
name: purine-nucleoside phosphorylase (Adenosine)
modifier: MODEL1310110061#
fast: false
is described by: ECO:0000269
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.4.2.1
product: MODEL1310110061#
reactant: MODEL1310110061#
kinetic law: MODEL1310110061#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110061#_ce7c421b_2c17_499e_ba98_38061cb61e9e
is encoded by: hsa:10654
initial amount: NaN
is: Q6FGV9
boundary condition: true
is: SBO:0000252
type: Species
name: PMVK
initial concentration: NaN
constant: false
has only substance units: false

metaR PIPLC
is version of: http://identifiers.org/ec-code/3.1.4.11
reversible: false
name: phosphatidylinositol phospholipase C
notes: GENE_ASSOCIATION: (23236.2) or (5336.1) or (23007.1) or (113026.1) or (89869.1) or (84812.1) or (9651.1) or (5335.1) or (51196.1) or (257068.1) or (5332.2) or (5331.1) or (5335.2) or (5334.1) or (5332.1) or (5330.1) or (23236.1) or (5333.1) SUBSYSTEM: Inositol phosphate metabolism EC Number: 3.1.4.3 Confidence Level: 4 AUTHORS: PMID:10702670,PMID:10702683,PMID:10760467,PMID:11022047,PMID:11022048,PMID:11118617,PMID:12117804,PMID:12213492,PMID:12416999,PMID:13333955,PMID:15140260,PMID:1644792,PMID:2167438,PMID:7607669,PMID:7612006,PMID:7633416,PMID:7789993,PMID:7835906,PMID:7849701,PMID:7890667,PMID:8530101,PMID:9345909 NOTES:NCD
is described by: ECO:0000000
reactant: MODEL1310110061#
modifier: MODEL1310110061#
type: Reaction
fast: false
kinetic law: MODEL1310110061#
product: MODEL1310110061#
is: SBO:0000176

metaM chsterol c
constant: false
is: SBO:0000247
name: cholesterol
initial amount: NaN
notes: FORMULA: C27H46O CHARGE: 0 INCHI: InChI=1S/C27H46O/c1-18(2)7-6-8-19(3)23-11-12-24-22-10-9-20-17-21(28)13-15-26(20,4)25(22)14-16-27(23,24)5/h9,18-19,21-25,28H,6-8,10-17H2,1-5H3/t19-,21+,22+,23-,24+,25+,26+,27-/m1/s1
initial concentration: 1.0
boundary condition: false
is: HMDB00067
type: Species
has only substance units: false
is: CHEBI:16113

metaR THRGLNNaEx
reversible: false
type: Reaction
notes: GENE_ASSOCIATION: (6510.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14530974 NOTES:SAB see Kanai and Hediger 2004 (2003), PMID 14530974
is: SBO:0000185
product: MODEL1310110061#
reactant: MODEL1310110061#
fast: false
is described by: ECO:0000269
name: L-threonine/L-glutamine Na-dependent exchange (Thr-L in)
kinetic law: MODEL1310110061#
modifier: MODEL1310110061#

metaR r1687
reversible: false
modifier: MODEL1310110061#
fast: false
type: Reaction
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
product: MODEL1310110061#
is: SBO:0000185
is described by: ECO:0000000
kinetic law: MODEL1310110061#
reactant: MODEL1310110061#
name: Y+LAT2 Utilized transport

metaM k c
type: Species
initial concentration: 1.0
has only substance units: false
is: C00238
is: HMDB00586
constant: false
initial amount: NaN
name: potassium
notes: FORMULA: K CHARGE: 1 HEPATONET_1.0_ABBREVIATION: HC00216 EHMN_ABBREVIATION: C00238
boundary condition: false
is: SBO:0000247
is: CHEBI:29103

http://identifiers.org/biomodels.db/MODEL1310110061#_793a37d0_0d75_45a5_8ebb_470459ee0e1b
constant: false
is encoded by: hsa:5313
boundary condition: true
initial concentration: NaN
initial amount: NaN
has only substance units: false
name: PKLR
is: SBO:0000252
type: Species

metaR r0157
kinetic law: MODEL1310110061#
modifier: MODEL1310110061#
is version of: http://identifiers.org/ec-code/6.3.4.2
notes: GENE_ASSOCIATION: (AA502753.1) or (1503.1) or (56474.1) SUBSYSTEM: Urea cycle EC Number: 2.6.1.15 Confidence Level: 0 AUTHORS: PMID:12850267,PMID:1296212,PMID:3003500,PMID:4762917,PMID:4797019,PMID:4822504,PMID:5059882 NOTES:
type: Reaction
product: MODEL1310110061#
reversible: false
is: SBO:0000176
is described by: ECO:0000000
name: L-Glutamine:pyruvate aminotransferase Glutamate metabolism EC:2.6.1.15
reactant: MODEL1310110061#
fast: false

metaR URATEt
type: Reaction
product: MODEL1310110061#
reactant: MODEL1310110061#
kinetic law: MODEL1310110061#
is described by: ECO:0000000
reversible: false
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:IT
name: urate export from cytosol
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110061#_59235761_0966_4df2_be79_14fbf6cc4f00
constant: false
boundary condition: true
initial concentration: NaN
name: ITPKA
type: Species
has only substance units: false
is: P23677
is encoded by: hsa:3706
is: SBO:0000252
initial amount: NaN

metaM HC02216 e
constant: false
boundary condition: false
initial amount: NaN
is: SBO:0000247
type: Species
has only substance units: false
initial concentration: 1.0
notes: FORMULA: C20H33O5 CHARGE: -1 INCHI: InChI=1S/C20H34O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h4,7,12-13,15-19,21-23H,2-3,5-6,8-11,14H2,1H3,(H,24,25)/b7-4-,13-12+/t15-,16+,17+,18+,19+/m0/s1
is: CHEBI:28922
name: prostaglandin-f2beta

metaR MACACI
reversible: false
modifier: MODEL1310110061#
product: MODEL1310110061#
is version of: http://identifiers.org/ec-code/2.5.1.18
kinetic law: MODEL1310110061#
name: maleylacetoacetate isomerase
fast: false
is described by: ECO:0000269
is: SBO:0000176
reactant: MODEL1310110061#
type: Reaction
notes: GENE_ASSOCIATION: (2954.1) or (2954.3) or (2954.2) SUBSYSTEM: Tyrosine metabolism EC Number: 5.2.1.2 Confidence Level: 4 AUTHORS: PMID:10373324 NOTES:NCD

metaR HEX1
notes: GENE_ASSOCIATION: (3098.3) or (80201.1) or (2645.3) or (3098.4) or (3099.1) or (2645.2) or (3098.5) or (2645.1) or (3098.1) or (3101.1) or (3098.2) SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: Confidence Level: 2 AUTHORS: NOTES:
is version of: http://identifiers.org/ec-code/2.7.1.2
name: hexokinase (D-glucose:ATP)
reactant: MODEL1310110061#
product: MODEL1310110061#
is version of: http://identifiers.org/ec-code/2.7.1.1
modifier: MODEL1310110061#
reversible: false
fast: false
kinetic law: MODEL1310110061#
is described by: ECO:0000134
type: Reaction
is: SBO:0000176

metaM thcholstoic x
is: SBO:0000247
is: HMDB03873
notes: FORMULA: C27H45O5 CHARGE: -1 INCHI: InChI=1S/C27H46O5/c1-15(6-5-7-16(2)25(31)32)19-8-9-20-24-21(14-23(30)27(19,20)4)26(3)11-10-18(28)12-17(26)13-22(24)29/h15-24,28-30H,5-14H2,1-4H3,(H,31,32)/t15-,16?,17+,18-,19-,20+,21+,22-,23+,24+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01340 EHMN_ABBREVIATION: C04722
initial amount: NaN
name: 3alpha,7alpha,12alpha-Trihydroxy-5beta-cholestanoate
boundary condition: false
has only substance units: false
is: CHEBI:18402
constant: false
type: Species
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110061#_abb750ef_e2d4_4416_9d08_250fe5927514
name: ALDH4A1
constant: false
boundary condition: true
is: SBO:0000252
type: Species
has only substance units: false
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:8659

http://identifiers.org/biomodels.db/MODEL1310110061#_f66c2ed4_2399_40c3_a678_546eab7031f3
name: NDUFB8
is: SBO:0000252
type: Species
is encoded by: hsa:4714
constant: false
initial concentration: NaN
is: O95169
has only substance units: false
initial amount: NaN
boundary condition: true

metaM dgmp c
is: HMDB01044
initial concentration: 1.0
notes: FORMULA: C10H12N5O7P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00306 EHMN_ABBREVIATION: C00362
constant: false
name: dGMP
is: SBO:0000247
initial amount: NaN
has only substance units: false
boundary condition: false
is: CHEBI:57673
is: C00362
type: Species

http://identifiers.org/biomodels.db/MODEL1310110061#_b6f10c06_886b_4539_a3ed_c8d7d6d8467d
type: Species
is: SBO:0000252
constant: false
initial amount: NaN
is encoded by: hsa:5320
name: PLA2G2A
is: P14555
boundary condition: true
has only substance units: false
initial concentration: NaN

metaM dgtp e
notes: FORMULA: C10H12N5O13P3 CHARGE: -4 INCHI: InChI=1S/C10H16N5O13P3/c11-10-13-8-7(9(17)14-10)12-3-15(8)6-1-4(16)5(26-6)2-25-30(21,22)28-31(23,24)27-29(18,19)20/h3-6,16H,1-2H2,(H,21,22)(H,23,24)(H2,18,19,20)(H3,11,13,14,17)/t4-,5+,6+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00252 EHMN_ABBREVIATION: C00286
initial amount: NaN
initial concentration: 1.0
has only substance units: false
constant: false
is: CHEBI:16497
boundary condition: false
name: dGTP
type: Species
is: SBO:0000247
is: HMDB01440

http://identifiers.org/biomodels.db/MODEL1310110061#_0342033b_c2ac_4c74_babc_b70643f531d6
type: Species
is: SBO:0000252
is: Q86YU0
is encoded by: hsa:766
name: CA7
constant: false
has only substance units: false
initial concentration: NaN
boundary condition: true
initial amount: NaN

metaR r0085
modifier: MODEL1310110061#
fast: false
reactant: MODEL1310110061#
type: Reaction
is described by: ECO:0000000
kinetic law: MODEL1310110061#
is version of: http://identifiers.org/ec-code/1.1.1.42
is: SBO:0000176
reversible: false
notes: GENE_ASSOCIATION: (AI971036.1) or (3417.1) or (3418.1) SUBSYSTEM: Urea cycle EC Number: 3.5.1.3 Confidence Level: 0 AUTHORS: PMID:3003502,PMID:319948,PMID:4436326,PMID:5114531,PMID:894284 NOTES:
name: 2-Oxoglutaramate amidohydrolase Glutamate metabolism EC:3.5.1.3
product: MODEL1310110061#

metaR HMGLx
name: hydroxymethylglutaryl-CoA lyase
fast: false
reactant: MODEL1310110061#
reversible: false
is described by: ECO:0000134
kinetic law: MODEL1310110061#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/4.1.3.4
modifier: MODEL1310110061#
product: MODEL1310110061#
notes: GENE_ASSOCIATION: (3155.1) SUBSYSTEM: Cholesterol metabolism EC Number: 4.1.3.4 Confidence Level: 4 AUTHORS: PMID:11111079 NOTES:TV NJ added peroxisomal version - see Olivier Biochimica et Biophysica Act 1529 (2000) 89-102
type: Reaction

metaR EX HC01610 LPAREN e RPAREN
kinetic law: MODEL1310110061#
reactant: MODEL1310110061#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of CoproporphyrinogenI
type: Reaction

metaM pmtcrn x
constant: false
type: Species
notes: FORMULA: C23H45NO4 CHARGE: 0 INCHI: InChI=1S/C23H45NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-23(27)28-21(19-22(25)26)20-24(2,3)4/h21H,5-20H2,1-4H3/t21-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01034 EHMN_ABBREVIATION: C02990
is: SBO:0000247
is: HMDB00222
initial amount: NaN
is: CHEBI:17490
boundary condition: false
has only substance units: false
name: L-palmitoylcarnitine
initial concentration: 1.0

metaR PUNP2
name: purine-nucleoside phosphorylase (Deoxyadenosine)
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.4.2.1
product: MODEL1310110061#
modifier: MODEL1310110061#
fast: false
reactant: MODEL1310110061#
kinetic law: MODEL1310110061#
type: Reaction
reversible: true
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (4860.1) SUBSYSTEM: Purine catabolism EC Number: 3.4.2.1 Confidence Level: 4 AUTHORS: PMID:6087295,PMID:9305963 NOTES:Specificity not completely determined. Can also catalyse ribosyltransferase reactions of the type catalysed by EC 2.4.2.5, nucleoside ribosyltransferase

metaM tettet6 e
initial concentration: 1.0
name: tetracosatetraenoic acid n-6
is: HMDB06246
initial amount: NaN
notes: FORMULA: C24H39O2 CHARGE: -1 INCHI: InChI=1/C24H40O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-24(25)26/h16-23H,2-15H2,1H3,(H,25,26)/b17-16+,19-18+,21-20+,23-22+
type: Species
boundary condition: false
is: SBO:0000247
constant: false
has only substance units: false

metaR EX cys L LPAREN e RPAREN
kinetic law: MODEL1310110061#
reactant: MODEL1310110061#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for L-cysteine
type: Reaction

metaR r0086
reversible: false
notes: GENE_ASSOCIATION: (56954.1) SUBSYSTEM: Urea cycle EC Number: 3.5.1.3 Confidence Level: 0 AUTHORS: PMID:3003502,PMID:319948,PMID:4436326,PMID:5114531,PMID:894284 NOTES:
is version of: http://identifiers.org/ec-code/3.5.1.3
type: Reaction
fast: false
is described by: ECO:0000000
product: MODEL1310110061#
reactant: MODEL1310110061#
modifier: MODEL1310110061#
kinetic law: MODEL1310110061#
is: SBO:0000176
name: 2-Oxoglutaramate amidohydrolase Glutamate metabolism EC:3.5.1.3

metaR r0156
reversible: false
is version of: http://identifiers.org/ec-code/2.7.1.40
reactant: MODEL1310110061#
kinetic law: MODEL1310110061#
type: Reaction
product: MODEL1310110061#
notes: GENE_ASSOCIATION: (H77542.1) or (5313.1) or (5315.1) SUBSYSTEM: Urea cycle EC Number: 2.6.1.15 Confidence Level: 0 AUTHORS: PMID:12850267,PMID:1296212,PMID:3003500,PMID:4762917,PMID:4797019,PMID:4822504,PMID:5059882 NOTES:
is: SBO:0000176
fast: false
is described by: ECO:0000000
modifier: MODEL1310110061#
name: L-Glutamine:pyruvate aminotransferase Glutamate metabolism EC:2.6.1.15

metaM HC02210 c
name: prostaglandin-d3
boundary condition: false
is: CHEBI:34939
initial amount: NaN
constant: false
is: SBO:0000247
has only substance units: false
type: Species
initial concentration: 1.0
notes: FORMULA: C20H29O5 CHARGE: -1 INCHI: InChI=1S/C20H30O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h3-4,6-7,12-13,15-18,21-22H,2,5,8-11,14H2,1H3,(H,24,25)/b6-3-,7-4-,13-12+/t15-,16+,17+,18-/m0/s1

metaR GALt4
kinetic law: MODEL1310110061#
name: galactose transport via sodium symport
reactant: MODEL1310110061#
reversible: true
is described by: ECO:0000269
type: Reaction
notes: GENE_ASSOCIATION: (200010.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12748858,PMID:15607332 NOTES:NCD
modifier: MODEL1310110061#
is: SBO:0000185
fast: false
product: MODEL1310110061#

http://identifiers.org/biomodels.db/MODEL1310110061#_8d443f12_a0b5_4c59_be20_a5fe4953cec1
name: PIK3C2A
initial concentration: NaN
type: Species
boundary condition: true
is: SBO:0000252
is encoded by: hsa:5286
has only substance units: false
initial amount: NaN
is: O00443
constant: false

metaR THP2Ctp
fast: false
reversible: true
product: MODEL1310110061#
name: 2,3,4,5-Tetrahydropyridine-2-carboxylate transport, peroxisomal
type: Reaction
is described by: ECO:0000000
reactant: MODEL1310110061#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 1 AUTHORS: NOTES:MM
kinetic law: MODEL1310110061#

metaR PYRt2r
kinetic law: MODEL1310110061#
type: Reaction
fast: false
reversible: true
name: pyruvate reversible transport via proton symport
product: MODEL1310110061#
is: SBO:0000185
modifier: MODEL1310110061#
reactant: MODEL1310110061#
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (9123.1) or (9194.1) or (6566.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10510291,PMID:11101640,PMID:12739169,PMID:7835905,PMID:8476015,PMID:9425115,PMID:9508842,PMID:9649795,PMID:9786900,PMID:9824713 NOTES:JLR

metaR r0644
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 1.2.3.1 Confidence Level: 0 AUTHORS: PMID:11569919,PMID:16143537 NOTES:
type: Reaction
kinetic law: MODEL1310110061#
reversible: true
is: SBO:0000176
product: MODEL1310110061#
reactant: MODEL1310110061#
name: (S)-Methylmalonate semialdehyde:oxygen oxidoreductase Valine, leucine and isoleucine degradation EC:1.2.3.1
is described by: ECO:0000000
fast: false

metaM q10h2 c
is: http://identifiers.org/pubchem.compound/6504740
has only substance units: false
notes: FORMULA: C59H92O4 CHARGE: 0 INCHI: InChI=1/C59H92O4/c1-44(2)24-15-25-45(3)26-16-27-46(4)28-17-29-47(5)30-18-31-48(6)32-19-33-49(7)34-20-35-50(8)36-21-37-51(9)38-22-39-52(10)40-23-41-53(11)42-43-55-54(12)56(60)58(62-13)59(63-14)57(55)61/h24,26,28,30,32,34,36,38,40,42,60-61H,15-23,25,27,29,31,33,35,37,39,41,43H2,1-14H3/b45-26+,46-28+,47-30+,48-32+,49-34+,50-36+,51-38+,52-40+,53-42+ HEPATONET_1.0_ABBREVIATION: HC00324
is: SBO:0000247
name: Ubiquinol-10
initial amount: NaN
initial concentration: 1.0
boundary condition: false
constant: false
type: Species
is: HMDB13111

http://identifiers.org/biomodels.db/MODEL1310110061#_1796edaf_8cbf_4f7f_9b3c_cb50d3ff60ef
constant: false
boundary condition: true
is: O15327
initial amount: NaN
is: SBO:0000252
type: Species
name: INPP4B
has only substance units: false
is encoded by: hsa:8821
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110061#_3d8a895b_89f5_4637_9d6c_879592b01894
has only substance units: false
type: Species
initial amount: NaN
is encoded by: hsa:2645
boundary condition: true
name: GCK
constant: false
initial concentration: NaN
is: SBO:0000252

metaR GGH 7DHFe
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (8836.1) SUBSYSTEM: Folate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:11375437,PMID:2867095,PMID:9614206 NOTES:REMOVES EITHER ONE OR TWO GLUTAMYL RESIDUES WITH A REACTION (WILL ONLY REPRESENT 1) IT
reactant: MODEL1310110061#
name: Gamma-glutamyl hydrolase (7DHF), extracellular
kinetic law: MODEL1310110061#
is: SBO:0000176
product: MODEL1310110061#
reversible: false
is version of: http://identifiers.org/ec-code/3.4.19.9
type: Reaction
modifier: MODEL1310110061#
fast: false

http://identifiers.org/biomodels.db/MODEL1310110061#_76ad5992_7e32_46e8_99a6_21de748a8f63
initial amount: NaN
is encoded by: hsa:4329
is: SBO:0000252
has only substance units: false
type: Species
boundary condition: true
constant: false
initial concentration: NaN
name: ALDH6A1
is: Q02252

metaR EX rib D LPAREN e RPAREN
kinetic law: MODEL1310110061#
reactant: MODEL1310110061#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for ribose
type: Reaction

metaR RE1530C
type: Reaction
name: RE1530
is: SBO:0000176
kinetic law: MODEL1310110061#
reactant: MODEL1310110061#
reversible: true
product: MODEL1310110061#
fast: false
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Pyrimidine synthesis EC Number: 2.7.1.21 Confidence Level: 0 AUTHORS: PMID:11812127 NOTES:

metaM asp L c
is: SBO:0000247
initial concentration: 1.0
is: HMDB00191
constant: false
notes: FORMULA: C4H6NO4 CHARGE: -1 INCHI: InChI=1S/C4H7NO4/c5-2(4(8)9)1-3(6)7/h2H,1,5H2,(H,6,7)(H,8,9)/p-1/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00055
initial amount: NaN
name: L-aspartate(1-)
boundary condition: false
has only substance units: false
type: Species
is: CHEBI:29991

http://identifiers.org/biomodels.db/MODEL1310110061#_d7790633_fa9c_4d5b_8770_83ded2ddd806
is: P04179
is encoded by: hsa:6648
type: Species
initial concentration: NaN
initial amount: NaN
boundary condition: true
constant: false
name: SOD2
has only substance units: false
is: SBO:0000252

metaR PUNP3
product: MODEL1310110061#
is: SBO:0000176
name: purine-nucleoside phosphorylase (Guanosine)
fast: false
reversible: true
notes: GENE_ASSOCIATION: (4860.1) SUBSYSTEM: Purine catabolism EC Number: 3.4.2.1 Confidence Level: 4 AUTHORS: PMID:6087295,PMID:9305963 NOTES:Specificity not completely determined. Can also catalyse ribosyltransferase reactions of the type catalysed by EC 2.4.2.5, nucleoside ribosyltransferase
reactant: MODEL1310110061#
type: Reaction
modifier: MODEL1310110061#
is version of: http://identifiers.org/ec-code/2.4.2.1
is described by: ECO:0000269
kinetic law: MODEL1310110061#

metaM 4hglusa m
is: HMDB06556
constant: false
has only substance units: false
name: L-4-hydroxyglutamic semialdehyde
is: SBO:0000247
initial concentration: 1.0
notes: FORMULA: C5H9NO4 CHARGE: 0 INCHI: InChI=1S/C5H9NO4/c6-4(5(9)10)1-3(8)2-7/h2-4,8H,1,6H2,(H,9,10)/t3-,4+/m1/s1 EHMN_ABBREVIATION: C05938
initial amount: NaN
is: CHEBI:27809
type: Species
boundary condition: false

metaM pail4p hs n
name: 1-phosphatidyl-1D-myo-inositol 4-phosphate(3-)
initial concentration: 1.0
constant: false
notes: FORMULA: C9H15O12P2FULLRCO2FULLR2CO2 CHARGE: -3 EHMN_ABBREVIATION: C01277
boundary condition: false
is: CHEBI:58178
has only substance units: false
initial amount: NaN
type: Species
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110061#_da27d3de_19a1_4137_bc5e_6a2ed6d29080
initial amount: NaN
type: Species
has only substance units: false
boundary condition: true
is: SBO:0000252
is encoded by: hsa:66035
name: SLC2A11
constant: false
initial concentration: NaN
is: Q8WXF9

metaM dopaqn c
initial amount: NaN
notes: FORMULA: C9H9NO4 CHARGE: 0 INCHI: InChI=1S/C9H9NO4/c10-6(9(13)14)3-5-1-2-7(11)8(12)4-5/h1-2,4,6H,3,10H2,(H,13,14)/t6-/m0/s1 EHMN_ABBREVIATION: C00822
is: SBO:0000247
name: L-dopaquinone
is: HMDB01229
type: Species
initial concentration: 1.0
boundary condition: false
constant: false
has only substance units: false
is: CHEBI:16852

metaR r2318
is: SBO:0000185
fast: false
is described by: ECO:0000000
reversible: true
product: MODEL1310110061#
reactant: MODEL1310110061#
kinetic law: MODEL1310110061#
type: Reaction
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:

metaM apoC Lys m
initial concentration: 1.0
is: CHEBI:32551
boundary condition: false
notes: FORMULA: C6H13N2OX CHARGE: 0
initial amount: NaN
has only substance units: false
is: SBO:0000247
name: Apocarboxylase (Lys residue)
constant: false
type: Species
is: HMDB00182

http://identifiers.org/biomodels.db/MODEL1310110061#_abe0b072_5df6_4d80_bdf7_e188cf48422b
is encoded by: hsa:3295
has only substance units: false
boundary condition: true
constant: false
type: Species
is: E9PB82
initial concentration: NaN
is: SBO:0000252
name: HSD17B4
initial amount: NaN

metaM his L e
initial concentration: 1.0
constant: false
name: L-histidine
boundary condition: false
has only substance units: false
notes: FORMULA: C6H9N3O2 CHARGE: 0 INCHI: InChI=1S/C6H9N3O2/c7-5(6(10)11)1-4-2-8-3-9-4/h2-3,5H,1,7H2,(H,8,9)(H,10,11)/t5-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00133
type: Species
is: SBO:0000247
initial amount: NaN
is: CHEBI:15971
is: HMDB00177

metaM 2maacoa m
initial amount: NaN
boundary condition: false
notes: FORMULA: C26H38N7O18P3S CHARGE: -4 INCHI: InChI=1S/C26H42N7O18P3S/c1-13(14(2)34)25(39)55-8-7-28-16(35)5-6-29-23(38)20(37)26(3,4)10-48-54(45,46)51-53(43,44)47-9-15-19(50-52(40,41)42)18(36)24(49-15)33-12-32-17-21(27)30-11-31-22(17)33/h11-13,15,18-20,24,36-37H,5-10H2,1-4H3,(H,28,35)(H,29,38)(H,43,44)(H,45,46)(H2,27,30,31)(H2,40,41,42)/p-4/t13?,15-,18-,19-,20+,24-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01101 EHMN_ABBREVIATION: C03344
name: 2-methylacetoacetyl-CoA(4-)
type: Species
constant: false
is: SBO:0000247
has only substance units: false
is: HMDB01157
initial concentration: 1.0
is: CHEBI:57335

metaR r0960
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:1554704,PMID:18021224,PMID:4553030,PMID:8725559 NOTES:
kinetic law: MODEL1310110061#
reactant: MODEL1310110061#
is described by: ECO:0000000
fast: false
is: SBO:0000185
reversible: true
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.65.1.1
product: MODEL1310110061#

metaR r0641
modifier: MODEL1310110061#
type: Reaction
reversible: true
is version of: http://identifiers.org/ec-code/3.1.2.4
notes: GENE_ASSOCIATION: (26275.1) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.2.2 Confidence Level: 0 AUTHORS: PMID:1968061 NOTES:
is: SBO:0000176
fast: false
kinetic law: MODEL1310110061#
product: MODEL1310110061#
name: (5-Glutamyl)-peptide:amino-acid 5-glutamyltransferase Arachidonic acid metabolism EC:2.3.2.2
is described by: ECO:0000000
reactant: MODEL1310110061#

metaR DM T antigen g
kinetic law: MODEL1310110061#
reactant: MODEL1310110061#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 0 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: DM T antigen(g)
type: Reaction

metaR PI4P3K
reactant: MODEL1310110061#
fast: false
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/2.7.1.153
is version of: http://identifiers.org/ec-code/2.7.1.154
product: MODEL1310110061#
name: phosphatidylinositol 4-phosphate 3-kinase
reversible: false
is version of: http://identifiers.org/ec-code/2.7.11.1
modifier: MODEL1310110061#
is: SBO:0000176
type: Reaction
notes: GENE_ASSOCIATION: (5291.1 and 5295.3) or (5296.1 and 5290.1) or (5293.1 and 5296.1) or (5287.1) or (5286.1) or (5293.1 and 8503.1) or (5293.1 and 5295.3) or (5291.1 and 8503.1) or (5295.2 and 5290.1) or (5288.1) or (5291.1 and 5295.1) or (5296.1 and 5291.1) or (23533.1 and 5294.1) or (5293.1 and 5295.1) or (5295.2 and 5293.1) or (5290.1 and 8503.1) or (5290.1 and 5295.3) or (10870.1 and 5294.1) or (5295.2 and 5291.1) or (5290.1 and 5295.1) SUBSYSTEM: Inositol phosphate metabolism EC Number: 2.7.1.68 Confidence Level: 4 AUTHORS: PMID:7624799,PMID:7713498,PMID:8246984,PMID:9113989,PMID:9337861,PMID:9830063,PMID:9878262 NOTES:NCD Notice that contrary to some standards in texts, KEGG, etc, the Rtotal group accounts for the whole fatty acyl CoA (so the CHO only accounts for the core backbone), manner in which Rtotal was produced accounts for O and H balances. Formation of the Rtotal group (rxn flux)accounted for mass balance for CoA NJ changed EC from 2.7.1.149 (pail5p) to 2.7.1.68 (pail4p) - NCD
kinetic law: MODEL1310110061#

metaR r0083
modifier: MODEL1310110061#
fast: false
reactant: MODEL1310110061#
is version of: http://identifiers.org/ec-code/1.1.1.42
kinetic law: MODEL1310110061#
type: Reaction
is described by: ECO:0000000
product: MODEL1310110061#
name: Oxalosuccinate:NADP+ oxidoreductase (decarboxylating) Citrate cycle (TCA cycle) EC:1.1.1.42
reversible: true
notes: GENE_ASSOCIATION: (AI971036.1) or (3417.1) or (3418.1) SUBSYSTEM: Unassigned EC Number: 1.1.1.42 Confidence Level: 0 AUTHORS: PMID:16489927,PMID:9866202 NOTES:
is: SBO:0000176

metaR PPNCL3
reactant: MODEL1310110061#
is version of: http://identifiers.org/ec-code/6.3.2.5
product: MODEL1310110061#
reversible: false
name: phosphopantothenate-cysteine ligase
modifier: MODEL1310110061#
kinetic law: MODEL1310110061#
type: Reaction
notes: GENE_ASSOCIATION: (79717.1) SUBSYSTEM: CoA synthesis EC Number: Confidence Level: 4 AUTHORS: NOTES:
is described by: ECO:0000269
is: SBO:0000176
fast: false

http://identifiers.org/biomodels.db/MODEL1310110061#_ad592092_147c_4f77_a393_6aaba49b21cf
is encoded by: hsa:2224
is: SBO:0000252
boundary condition: true
has only substance units: false
type: Species
initial amount: NaN
constant: false
initial concentration: NaN
name: FDPS
is: P14324

http://identifiers.org/biomodels.db/MODEL1310110061#_4aa302ee_e248_4d31_a30c_c53a739c8896
initial amount: NaN
is: SBO:0000297
type: Species
name: EHHADH:ACAA1:ACOX1
is encoded by: hsa:1962
has only substance units: false
boundary condition: true
initial concentration: NaN
constant: false
has part: Q9NY65

metaM h g
has only substance units: false
name: proton
initial amount: NaN
notes: FORMULA: H CHARGE: 1 INCHI: InChI=1S/p+1/i/hH HEPATONET_1.0_ABBREVIATION: HC00083 EHMN_ABBREVIATION: C00080
boundary condition: false
is: SBO:0000247
initial concentration: 1.0
is: CHEBI:24636
constant: false
type: Species

metaR PUNP4
name: purine-nucleoside phosphorylase (Deoxyguanosine)
modifier: MODEL1310110061#
is described by: ECO:0000269
product: MODEL1310110061#
is: SBO:0000176
reversible: true
reactant: MODEL1310110061#
type: Reaction
is version of: http://identifiers.org/ec-code/2.4.2.1
kinetic law: MODEL1310110061#
fast: false
notes: GENE_ASSOCIATION: (4860.1) SUBSYSTEM: Purine catabolism EC Number: 3.4.2.1 Confidence Level: 4 AUTHORS: PMID:6087295,PMID:9305963 NOTES:Specificity not completely determined. Can also catalyse ribosyltransferase reactions of the type catalysed by EC 2.4.2.5, nucleoside ribosyltransferase

http://identifiers.org/biomodels.db/MODEL1310110061#_2fb7b356_1d25_4d88_99cf_49faecc55909
has only substance units: false
name: MTHFD1L
boundary condition: true
type: Species
constant: false
is: B2RD24
initial amount: NaN
is encoded by: hsa:25902
is: SBO:0000252
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110061#_9d9f6a7c_08ac_4f14_9ee7_cd05e95e8d99
has only substance units: false
boundary condition: true
name: NDUFB6
is: SBO:0000252
constant: false
initial concentration: NaN
is: O95139
initial amount: NaN
is encoded by: hsa:4712
type: Species

metaM HC02210 e
is: CHEBI:34939
initial amount: NaN
type: Species
has only substance units: false
name: prostaglandin-d3
notes: FORMULA: C20H29O5 CHARGE: -1 INCHI: InChI=1S/C20H30O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h3-4,6-7,12-13,15-18,21-22H,2,5,8-11,14H2,1H3,(H,24,25)/b6-3-,7-4-,13-12+/t15-,16+,17+,18-/m0/s1
boundary condition: false
constant: false
is: SBO:0000247
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110061#_865f499a_ecfb_49fc_a5df_feb3f09d5ddd
name: EHHADH:ACAA1:ACOX1
has only substance units: false
initial amount: NaN
boundary condition: true
is: SBO:0000297
has part: Q15067
constant: false
is encoded by: hsa:51
initial concentration: NaN
type: Species

metaR r2319
product: MODEL1310110061#
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
is: SBO:0000185
fast: false
reactant: MODEL1310110061#
kinetic law: MODEL1310110061#
type: Reaction
is described by: ECO:0000000
reversible: true

metaR DNDPt38m
fast: false
kinetic law: MODEL1310110061#
is: SBO:0000185
name: dUTP transport via dUDP antiport
type: Reaction
is described by: ECO:0000269
reversible: false
modifier: MODEL1310110061#
notes: GENE_ASSOCIATION: (60386.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:11226231 NOTES:IT
product: MODEL1310110061#
reactant: MODEL1310110061#

metaM txa2 r
initial amount: NaN
is: CHEBI:57445
has only substance units: false
notes: FORMULA: C20H31O5 CHARGE: -1 INCHI: InChI=1S/C20H32O5/c1-2-3-6-9-15(21)12-13-17-16(18-14-20(24-17)25-18)10-7-4-5-8-11-19(22)23/h4,7,12-13,15-18,20-21H,2-3,5-6,8-11,14H2,1H3,(H,22,23)/p-1/b7-4-,13-12+/t15-,16+,17+,18-,20+/m0/s1 EHMN_ABBREVIATION: C02198
is: SBO:0000247
is: HMDB01452
name: thromboxane A2(1-)
initial concentration: 1.0
constant: false
boundary condition: false
type: Species

metaR HEXCt
is: SBO:0000185
name: fatty acid transport via diffusion
fast: false
type: Reaction
reactant: MODEL1310110061#
reversible: true
product: MODEL1310110061#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11788354,PMID:12864740 NOTES:NJ
kinetic law: MODEL1310110061#

http://identifiers.org/biomodels.db/MODEL1310110061#_c33ea1bb_72be_4613_a7d9_43c9c5d8e0c0
is encoded by: hsa:84569
constant: false
type: Species
has only substance units: false
initial amount: NaN
name: LYZL1
boundary condition: true
is: SBO:0000252
is: Q6UWQ5
initial concentration: NaN

metaR r0642
is described by: ECO:0000000
reactant: MODEL1310110061#
kinetic law: MODEL1310110061#
product: MODEL1310110061#
name: (S)-Methylmalonate semialdehyde:NAD+ oxidoreductase Valine, leucine and isoleucine degradation EC:1.2.1.3
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 1.2.1.3 Confidence Level: 0 AUTHORS: PMID:10947204,PMID:10989432,PMID:1527093,PMID:16683190,PMID:8120000,PMID:8155713,PMID:8634152,PMID:9787093 NOTES:
type: Reaction
fast: false
reversible: true
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110061#_fce93cd7_853c_4eb3_bbb9_3012129d982d
is: SBO:0000252
boundary condition: true
type: Species
has only substance units: false
initial concentration: NaN
is encoded by: hsa:5236
constant: false
name: PGM1
initial amount: NaN
is: B4DPV0

http://identifiers.org/biomodels.db/MODEL1310110061#_141c9eb9_c55d_4eee_af40_3e4da6c15591
is encoded by: hsa:5232
is: P07205
constant: false
type: Species
name: PGK2
boundary condition: true
initial concentration: NaN
is: SBO:0000252
has only substance units: false
initial amount: NaN

metaR URIt
fast: false
type: Reaction
kinetic law: MODEL1310110061#
modifier: MODEL1310110061#
name: uridine facilated transport in cytosol
is described by: ECO:0000269
reactant: MODEL1310110061#
is: SBO:0000185
reversible: true
notes: GENE_ASSOCIATION: (3177.1) or (2030.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10722669,PMID:12838422 NOTES:IT
product: MODEL1310110061#

metaR EX dad 2 LPAREN e RPAREN
kinetic law: MODEL1310110061#
reactant: MODEL1310110061#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for 2-deoxyadenosine
type: Reaction

metaR RE1527M
name: RE1527
is version of: http://identifiers.org/ec-code/1.1.1.35
fast: false
is described by: ECO:0000000
reversible: true
is version of: http://identifiers.org/ec-code/4.2.1.107
reactant: MODEL1310110061#
modifier: MODEL1310110061#
type: Reaction
kinetic law: MODEL1310110061#
is: SBO:0000176
product: MODEL1310110061#
notes: GENE_ASSOCIATION: (3295.1) or (1962.1) or (3033.1) or (3028.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.1.1.35 Confidence Level: 0 AUTHORS: PMID:11451959 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110061#_e63318b5_7eba_437b_ae2f_8f5ec575d3bc
initial concentration: NaN
boundary condition: true
is: SBO:0000252
has only substance units: false
constant: false
type: Species
name: HAS3
initial amount: NaN
is encoded by: hsa:3038
is: Q96RV2

metaR NAt3 1
is: SBO:0000185
type: Reaction
name: sodium proton antiporter (H:NA is 1:1)
reactant: MODEL1310110061#
fast: false
notes: GENE_ASSOCIATION: (389015.1) or (6548.1) or (6550.1) or (6549.1) or (6553.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10444453,PMID:12845533,PMID:2536298,PMID:2581505,PMID:7631746,PMID:7759094,PMID:8199403,PMID:8595899,PMID:9933641 NOTES:JLR
reversible: true
is described by: ECO:0000269
product: MODEL1310110061#
kinetic law: MODEL1310110061#
modifier: MODEL1310110061#

metaR r1683
reactant: MODEL1310110061#
name: Y+LAT2 Utilized transport
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
type: Reaction
product: MODEL1310110061#
modifier: MODEL1310110061#
reversible: false
kinetic law: MODEL1310110061#
is described by: ECO:0000000
is: SBO:0000185
fast: false

metaR CYSTALArBATtc
kinetic law: MODEL1310110061#
product: MODEL1310110061#
reactant: MODEL1310110061#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of L-Cystine into the cell in exchange for L-Alanine by b0,+AT transporter at the apical surfaces of the membranes of small intestine and renal cells.
type: Reaction

metaR DM anth
kinetic law: MODEL1310110061#
reactant: MODEL1310110061#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: Demand for anthranilate
type: Reaction

metaM pglyc hs e
constant: false
type: Species
is: CHEBI:60523
initial concentration: 1.0
is: SBO:0000247
initial amount: NaN
has only substance units: false
name: phosphatidylglycerol(1-)
notes: FORMULA: C6H12O6PFULLRCO2FULLR2CO2 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC02096
boundary condition: false

metaM acac m
is: HMDB00060
constant: false
notes: FORMULA: C4H5O3 CHARGE: -1 INCHI: InChI=1S/C4H6O3/c1-3(5)2-4(6)7/h2H2,1H3,(H,6,7)/p-1 HEPATONET_1.0_ABBREVIATION: HC00159 EHMN_ABBREVIATION: C00164
type: Species
initial amount: NaN
has only substance units: false
is: CHEBI:13705
is: SBO:0000247
initial concentration: 1.0
name: acetoacetate
boundary condition: false

metaR PYRt2m
reversible: true
notes: GENE_ASSOCIATION: (6566.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:6987111 NOTES:IF changed name from "tm" to "t2m" - NCD
kinetic law: MODEL1310110061#
reactant: MODEL1310110061#
name: pyruvate mitochondrial transport via proton symport
is described by: ECO:0000000
fast: false
type: Reaction
is: SBO:0000185
modifier: MODEL1310110061#
product: MODEL1310110061#

metaR SERDGLYexR
name: D-Serine/Glycine reversible exchange
type: Reaction
fast: false
modifier: MODEL1310110061#
notes: GENE_ASSOCIATION: (56301.1) and (6520.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10734121,PMID:10863037,PMID:14770310 NOTES:
kinetic law: MODEL1310110061#
is described by: ECO:0000304
product: MODEL1310110061#
is: SBO:0000185
reversible: true
reactant: MODEL1310110061#

metaM Rtotal c
boundary condition: false
is: SBO:0000247
constant: false
initial concentration: 1.0
is: CHEBI:16189
has only substance units: false
type: Species
notes: FORMULA: CO2FULLR CHARGE: -1
name: R total
initial amount: NaN
is: HMDB01448

http://identifiers.org/biomodels.db/MODEL1310110061#_f9829544_5fdc_4a01_b5ea_5ff0f842cf66
initial concentration: NaN
name: PANK1
is: SBO:0000252
is encoded by: hsa:53354
boundary condition: true
initial amount: NaN
has only substance units: false
type: Species
constant: false

metaR r1538
is described by: ECO:0000000
modifier: MODEL1310110061#
reactant: MODEL1310110061#
reversible: false
product: MODEL1310110061#
is version of: http://identifiers.org/ec-code/1.17.4.1
notes: GENE_ASSOCIATION: (BE966236.1) or (6240.1) or (6241.1) or (50484.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14722772 NOTES:
is: SBO:0000185
kinetic law: MODEL1310110061#
fast: false
type: Reaction
name: Anion Exchanger (AE) TCDB:2.A.31.2.8

metaR PUNP5
name: purine-nucleoside phosphorylase (Inosine)
fast: false
is: SBO:0000176
product: MODEL1310110061#
is described by: ECO:0000269
reversible: true
reactant: MODEL1310110061#
is version of: http://identifiers.org/ec-code/2.4.2.1
type: Reaction
modifier: MODEL1310110061#
notes: GENE_ASSOCIATION: (4860.1) SUBSYSTEM: Purine catabolism EC Number: 3.4.2.1 Confidence Level: 4 AUTHORS: PMID:14706628,PMID:6087295,PMID:9305963 NOTES:Specificity not completely determined. Can also catalyse ribosyltransferase reactions of the type catalysed by EC 2.4.2.5, nucleoside ribosyltransferase
kinetic law: MODEL1310110061#

http://identifiers.org/biomodels.db/MODEL1310110061#_112776f3_20ba_42aa_bc57_cb5e836cfa88
is: P00374
initial concentration: NaN
initial amount: NaN
is: SBO:0000252
is encoded by: hsa:1719
boundary condition: true
type: Species
has only substance units: false
constant: false
name: DHFR

metaR r0081
product: MODEL1310110061#
is version of: http://identifiers.org/ec-code/1.5.1.12
fast: false
reversible: true
modifier: MODEL1310110061#
kinetic law: MODEL1310110061#
name: L-Alanine:2-oxoglutarate aminotransferase Glutamate metabolism / Alanine and aspartate metabolism EC:2.6.1.2
reactant: MODEL1310110061#
notes: GENE_ASSOCIATION: (8659.1) SUBSYSTEM: Citric acid cycle EC Number: 2.6.1.2 Confidence Level: 0 AUTHORS: PMID:15663181,PMID:2088925,PMID:454616 NOTES:
type: Reaction
is described by: ECO:0000000
is: SBO:0000176

metaM na1 e
notes: FORMULA: Na CHARGE: 1
has only substance units: false
is: SBO:0000247
is: HMDB00588
initial concentration: 1.0
constant: false
boundary condition: false
initial amount: NaN
type: Species
is: C01330
name: Sodium
is: CHEBI:4541

metaR r2373
is described by: ECO:0000000
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
reversible: true
reactant: MODEL1310110061#
fast: false
kinetic law: MODEL1310110061#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:16919238,PMID:17173541,PMID:18406340,PMID:8132483 NOTES:
is: SBO:0000185
type: Reaction
product: MODEL1310110061#

metaM h2o2 e
has only substance units: false
initial concentration: 1.0
constant: false
is: HMDB03125
initial amount: NaN
type: Species
is: CHEBI:16240
name: hydrogen peroxide
notes: FORMULA: H2O2 CHARGE: 0 INCHI: InChI=1S/H2O2/c1-2/h1-2H HEPATONET_1.0_ABBREVIATION: HC00036 EHMN_ABBREVIATION: C00027
boundary condition: false
is: SBO:0000247

metaR RE2814R
reactant: MODEL1310110061#
is: SBO:0000176
reversible: true
fast: false
kinetic law: MODEL1310110061#
name: RE2814
notes: GENE_ASSOCIATION: SUBSYSTEM: Bile acid synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:0 NOTES:
is described by: ECO:0000000
product: MODEL1310110061#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110061#_cffe0177_1b5d_40cb_a1c5_c197ff3beac9
boundary condition: true
constant: false
is encoded by: hsa:23396
type: Species
name: PIP5K1C
is: O60331
initial amount: NaN
initial concentration: NaN
has only substance units: false
is: SBO:0000252

metaR CYSSNAT5tc
kinetic law: MODEL1310110061#
product: MODEL1310110061#
reactant: MODEL1310110061#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: transport of L-Cysteine into the cell coupled with co-transport with Sodium and counter transport with proton by SNAT5 transporter.
type: Reaction

metaM ser L m
boundary condition: false
notes: FORMULA: C3H7NO3 CHARGE: 0 INCHI: InChI=1S/C3H7NO3/c4-2(1-5)3(6)7/h2,5H,1,4H2,(H,6,7)/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00068
has only substance units: false
is: SBO:0000247
initial concentration: 1.0
is: HMDB00187
constant: false
is: CHEBI:17115
name: L-serine
initial amount: NaN
type: Species

metaM his L c
initial concentration: 1.0
name: L-histidine
has only substance units: false
notes: FORMULA: C6H9N3O2 CHARGE: 0 INCHI: InChI=1S/C6H9N3O2/c7-5(6(10)11)1-4-2-8-3-9-4/h2-3,5H,1,7H2,(H,8,9)(H,10,11)/t5-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00133
constant: false
is: SBO:0000247
is: CHEBI:15971
initial amount: NaN
is: HMDB00177
boundary condition: false
type: Species

metaM lys L e
has only substance units: false
notes: FORMULA: C6H15N2O2 CHARGE: 1 INCHI: InChI=1S/C6H14N2O2/c7-4-2-1-3-5(8)6(9)10/h5H,1-4,7-8H2,(H,9,10)/p+1/t5-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00053 EHMN_ABBREVIATION: C00047
is: CHEBI:32551
name: L-lysinium(1+)
boundary condition: false
initial concentration: 1.0
constant: false
type: Species
is: HMDB00182
is: SBO:0000247
initial amount: NaN

metaR PPAm
notes: GENE_ASSOCIATION: (27068.4) or (27068.1) or (27068.3) or (27068.2) SUBSYSTEM: Oxidative phosphorylation EC Number: 3.6.1.1 Confidence Level: 4 AUTHORS: PMID:10542310,PMID:15533045 NOTES:IF
reversible: false
type: Reaction
modifier: MODEL1310110061#
reactant: MODEL1310110061#
product: MODEL1310110061#
name: inorganic diphosphatase
is: SBO:0000176
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/3.6.1.1
fast: false
kinetic law: MODEL1310110061#

metaR r1684
name: Y+LAT2 Utilized transport
type: Reaction
is: SBO:0000185
fast: false
product: MODEL1310110061#
kinetic law: MODEL1310110061#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reactant: MODEL1310110061#
modifier: MODEL1310110061#
reversible: false

metaR SMS
product: MODEL1310110061#
is described by: ECO:0000269
reactant: MODEL1310110061#
fast: false
kinetic law: MODEL1310110061#
notes: GENE_ASSOCIATION: (259230.1) SUBSYSTEM: Sphingolipid metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:14685263 NOTES:NJ
reversible: false
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.7.8.27
name: Sphingomyelin synthase (homo sapiens)
modifier: MODEL1310110061#
type: Reaction

metaM succ x
name: Succinate
notes: FORMULA: C4H4O4 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00049 EHMN_ABBREVIATION: C00042
is: HMDB00254
is: C00042
initial amount: NaN
initial concentration: 1.0
type: Species
boundary condition: false
has only substance units: false
is: SBO:0000247
is: CHEBI:30031
constant: false

metaR 3DSPHR
product: MODEL1310110061#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.1.1.102
name: 3-Dehydrosphinganine reductase
reversible: false
notes: GENE_ASSOCIATION: (2531.1) SUBSYSTEM: Sphingolipid metabolism EC Number: 1.1.1.102 Confidence Level: 4 AUTHORS: NOTES:
reactant: MODEL1310110061#
kinetic law: MODEL1310110061#
type: Reaction
fast: false
is described by: ECO:0000269
modifier: MODEL1310110061#

metaM nadh m
type: Species
boundary condition: false
is: SBO:0000247
constant: false
name: Nicotinamide adenine dinucleotide - reduced
is: HMDB01487
has only substance units: false
initial amount: NaN
is: CHEBI:57945
is: http://identifiers.org/pubchem.compound/3306
is: C00004
initial concentration: 1.0

metaR PUNP6
modifier: MODEL1310110061#
is: SBO:0000176
product: MODEL1310110061#
reversible: true
reactant: MODEL1310110061#
name: purine-nucleoside phosphorylase (Deoxyinosine)
is version of: http://identifiers.org/ec-code/2.4.2.1
type: Reaction
notes: GENE_ASSOCIATION: (4860.1) SUBSYSTEM: Purine catabolism EC Number: 3.4.2.1 Confidence Level: 4 AUTHORS: PMID:14706628,PMID:6087295,PMID:9305963 NOTES:Specificity not completely determined. Can also catalyse ribosyltransferase reactions of the type catalysed by EC 2.4.2.5, nucleoside ribosyltransferase
kinetic law: MODEL1310110061#
fast: false
is described by: ECO:0000269

metaM dcdp m
has only substance units: false
constant: false
is: SBO:0000247
is: HMDB01245
boundary condition: false
initial amount: NaN
type: Species
initial concentration: 1.0
notes: FORMULA: C9H12N3O10P2 CHARGE: -3 INCHI: InChI=1S/C9H15N3O10P2/c10-7-1-2-12(9(14)11-7)8-3-5(13)6(21-8)4-20-24(18,19)22-23(15,16)17/h1-2,5-6,8,13H,3-4H2,(H,18,19)(H2,10,11,14)(H2,15,16,17)/p-3/t5-,6+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00506 EHMN_ABBREVIATION: C00705
name: dCDP(3-)
is: CHEBI:58593

metaM ahcys c
type: Species
notes: FORMULA: C14H20N6O5S CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00031 EHMN_ABBREVIATION: C00021
constant: false
is: SBO:0000247
initial concentration: 1.0
initial amount: NaN
boundary condition: false
is: CHEBI:16680
is: C00021
name: S-Adenosyl-L-homocysteine
is: HMDB00939
has only substance units: false

metaM h e
type: Species
initial concentration: 1.0
is: SBO:0000247
initial amount: NaN
is: http://identifiers.org/pubchem.compound/3380
is: C00080
notes: FORMULA: H CHARGE: 1 INCHI: "
constant: false
is: CHEBI:24636
name: proton
has only substance units: false
boundary condition: false

metaR FAOXC226C225m
kinetic law: MODEL1310110061#
product: MODEL1310110061#
reactant: MODEL1310110061#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C22:6-->C22:5)m
type: Reaction

metaR NRVNCCOAtx
fast: false
name: fatty acid intracellular transport
type: Reaction
is: SBO:0000185
kinetic law: MODEL1310110061#
reversible: true
reactant: MODEL1310110061#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: NOTES:interaction between peroxisomes and ER (some enzymes on the outer membrane) NJ
product: MODEL1310110061#

metaR r0750
is: SBO:0000176
is described by: ECO:0000000
modifier: MODEL1310110061#
reversible: true
notes: GENE_ASSOCIATION: (2194.1) SUBSYSTEM: Bile acid synthesis EC Number: 1.1.1.50 Confidence Level: 0 AUTHORS: PMID:1591235,PMID:3459552 NOTES:
kinetic law: MODEL1310110061#
product: MODEL1310110061#
reactant: MODEL1310110061#
type: Reaction
is version of: http://identifiers.org/ec-code/2.3.1.85
name: 3alpha,7alpha,12alpha-Trihydroxy-5beta-cholestane:NADP+ oxidoreductase (B-specific); 3alpha,7alpha,12alpha-Trihydroxy-5beta-cholestane:NADP+ oxidoreductase Bile acid biosynthesis EC:1.1.1.50
fast: false

http://identifiers.org/biomodels.db/MODEL1310110061#_c0f9f60c_cddf_419a_acd2_cf93f99017e7
initial amount: NaN
is: E5KNH5
initial concentration: NaN
is: SBO:0000252
type: Species
constant: false
is encoded by: hsa:4723
has only substance units: false
name: NDUFV1
boundary condition: true

metaR 3HKYNAKGAT
reversible: false
fast: false
notes: GENE_ASSOCIATION: (51166.1) or (883.1) or (51166.2) SUBSYSTEM: Tryptophan metabolism EC Number: 2.6.1.7 Confidence Level: 2 AUTHORS: PMID:13357462 NOTES:SAB
is version of: http://identifiers.org/ec-code/2.6.1.7
name: 3-Hydroxy-L-kynurenine:2-oxoglutarate aminotransferase
kinetic law: MODEL1310110061#
reactant: MODEL1310110061#
modifier: MODEL1310110061#
product: MODEL1310110061#
type: Reaction
is version of: http://identifiers.org/ec-code/2.6.1.64
is: SBO:0000176
is described by: ECO:0000304

metaR r2372
type: Reaction
product: MODEL1310110061#
fast: false
is described by: ECO:0000000
is: SBO:0000185
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172 NOTES:
reversible: true
reactant: MODEL1310110061#
kinetic law: MODEL1310110061#

metaR EX dtmp LPAREN e RPAREN
kinetic law: MODEL1310110061#
reactant: MODEL1310110061#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of dTMP(2-)
type: Reaction

metaM g1p e
initial concentration: 1.0
is: SBO:0000247
constant: false
is: HMDB01586
type: Species
notes: FORMULA: C6H11O9P CHARGE: -2 INCHI: InChI=1S/C6H13O9P/c7-1-2-3(8)4(9)5(10)6(14-2)15-16(11,12)13/h2-10H,1H2,(H2,11,12,13)/p-2/t2-,3-,4+,5-,6-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00103 EHMN_ABBREVIATION: C00103
initial amount: NaN
name: alpha-D-glucose 1-phosphate(2-)
has only substance units: false
is: CHEBI:58601
boundary condition: false

metaR FADH2ETC
is: SBO:0000176
is described by: ECO:0000134
kinetic law: MODEL1310110061#
fast: false
product: MODEL1310110061#
reactant: MODEL1310110061#
reversible: false
name: Complex II reaction for respiratory chain
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Oxidative phosphorylation EC Number: Confidence Level: 4 AUTHORS: NOTES:

metaR HMGCOARc
kinetic law: MODEL1310110061#
product: MODEL1310110061#
reversible: false
reactant: MODEL1310110061#
notes: GENE_ASSOCIATION: (3156.1) SUBSYSTEM: Squalene and cholesterol synthesis EC Number: Confidence Level: 4 AUTHORS: Davidson, N. O., Magun, A. M. and Glickman, R. M. 2011. Enterocyte Lipid Absorption and Secretion. Comprehensive Physiology. 505?526, PMID: 17015489, PMID: 18216769, PMID: 6833883, PMID: 11229876. NOTES:Enterocytes stand next to liver in endogenous cholesterol synthesis. in rats they provide 25% of bodys cholesterol. the crypt epithelial cells synthesize maximum cholesterol when compared to other parts of the GI tract (PMCID: PMC292609). enzyme is located in E.R. but has catalytic site facing the cytosol (D.S. Sheriff (2004) Medical biochemistry, 1st edition Jaypee brothers Medical publishers pvt ltd page 502).
fast: false
is version of: http://identifiers.org/ec-code/1.1.1.34
type: Reaction
is: SBO:0000176
modifier: MODEL1310110061#
name: Hydroxymethylglutaryl CoA reductase (ir) in cytosol
is described by: ECO:0000134

metaM n2m2nmasn e
initial amount: NaN
is: C04946
is: SBO:0000247
has only substance units: false
type: Species
initial concentration: 1.0
constant: false
name: N-Acetyl-beta-D-glucosaminyl-1,2-alpha-D-mannosyl-1,3-(N-acetyl-beta-D-glucosaminyl-1,2-alpha-D-mannosyl-1,6)-(N-acetyl-beta-D-glucosaminyl-1,4)-beta-D-mannosyl-1,4-N-acetyl-beta-D-glucosaminyl-R
boundary condition: false
notes: FORMULA: C58H96N5O40X CHARGE: 0

metaR DPCOAPPe
reactant: MODEL1310110061#
notes: GENE_ASSOCIATION: SUBSYSTEM: CoA synthesis EC Number: Confidence Level: AUTHORS: NOTES:
reversible: false
kinetic law: MODEL1310110061#
type: Reaction
product: MODEL1310110061#
is: SBO:0000176
name: Pyrophasphatase (dephospho-CoA, extracellular)
is described by: ECO:0000134
fast: false

metaR RE2974C
type: Reaction
product: MODEL1310110061#
is: SBO:0000176
fast: false
notes: GENE_ASSOCIATION: (8395.1) or (23396.1) or (5305.1) or (8396.1) or (79837.1) or (8394.1) SUBSYSTEM: Phosphatidylinositol phosphate metabolism EC Number: 2.7.1.68 Confidence Level: 0 AUTHORS: PMID:10231032,PMID:10358929,PMID:11493657,PMID:9211928 NOTES:
reversible: true
modifier: MODEL1310110061#
is version of: http://identifiers.org/ec-code/2.7.1.149
is version of: http://identifiers.org/ec-code/2.7.1.68
kinetic law: MODEL1310110061#
is described by: ECO:0000000
reactant: MODEL1310110061#
name: RE2974

metaM k e
is: SBO:0000247
type: Species
initial amount: NaN
boundary condition: false
initial concentration: 1.0
is: HMDB00586
notes: FORMULA: K CHARGE: 1 HEPATONET_1.0_ABBREVIATION: HC00216 EHMN_ABBREVIATION: C00238
constant: false
name: potassium
is: C00238
is: CHEBI:29103
has only substance units: false

metaM cysam c
is: HMDB02991
boundary condition: false
notes: FORMULA: C2H8NS CHARGE: 1 INCHI: InChI=1S/C2H7NS/c3-1-2-4/h4H,1-3H2/p+1 HEPATONET_1.0_ABBREVIATION: HC00823 EHMN_ABBREVIATION: C01678
constant: false
type: Species
has only substance units: false
initial amount: NaN
is: SBO:0000247
is: CHEBI:58029
initial concentration: 1.0
name: cysteaminium

metaM pglyc hs c
has only substance units: false
boundary condition: false
is: SBO:0000247
initial concentration: 1.0
is: CHEBI:60523
type: Species
notes: FORMULA: C6H12O6PFULLRCO2FULLR2CO2 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC02096
initial amount: NaN
constant: false
name: phosphatidylglycerol(1-)

metaM Rtotal e
boundary condition: false
initial concentration: 1.0
type: Species
has only substance units: false
is: HMDB00244
initial amount: NaN
notes: FORMULA: CO2FULLR CHARGE: -1
is: CHEBI:3554
name: R total
is: C00255
is: SBO:0000247
constant: false

metaM chsterol e
initial amount: NaN
has only substance units: false
constant: false
boundary condition: false
is: SBO:0000247
is: CHEBI:16113
type: Species
notes: FORMULA: C27H46O CHARGE: 0 INCHI: InChI=1S/C27H46O/c1-18(2)7-6-8-19(3)23-11-12-24-22-10-9-20-17-21(28)13-15-26(20,4)25(22)14-16-27(23,24)5/h9,18-19,21-25,28H,6-8,10-17H2,1-5H3/t19-,21+,22+,23-,24+,25+,26+,27-/m1/s1
initial concentration: 1.0
name: cholesterol
is: HMDB00067

metaM dcdp n
type: Species
is: HMDB01245
notes: FORMULA: C9H12N3O10P2 CHARGE: -3 INCHI: InChI=1S/C9H15N3O10P2/c10-7-1-2-12(9(14)11-7)8-3-5(13)6(21-8)4-20-24(18,19)22-23(15,16)17/h1-2,5-6,8,13H,3-4H2,(H,18,19)(H2,10,11,14)(H2,15,16,17)/p-3/t5-,6+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00506 EHMN_ABBREVIATION: C00705
boundary condition: false
name: dCDP(3-)
initial concentration: 1.0
is: CHEBI:58593
constant: false
is: SBO:0000247
has only substance units: false
initial amount: NaN

metaM thf c
initial amount: NaN
name: 5,6,7,8-Tetrahydrofolate
type: Species
boundary condition: false
constant: false
is: CHEBI:57453
initial concentration: 1.0
is: SBO:0000247
is: HMDB01846
notes: FORMULA: C19H21N7O6 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00102 EHMN_ABBREVIATION: C00101
is: C00101
has only substance units: false

metaR PVD3
reactant: MODEL1310110061#
name: Previtamin D3 formation
kinetic law: MODEL1310110061#
reversible: true
product: MODEL1310110061#
is: SBO:0000176
is described by: ECO:0000134
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Vitamin D metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:6281884 NOTES:This reaction takes place in skin and needs UV 290-305. based on Vitamins, G.F.M. Ball,2004, Blackwell publishing, 1st ed (book) pg.194 IT
type: Reaction

metaM na1 c
has only substance units: false
initial concentration: 1.0
is: SBO:0000247
is: HMDB00588
constant: false
boundary condition: false
type: Species
name: Sodium
is: C01330
initial amount: NaN
is: CHEBI:4541
notes: FORMULA: Na CHARGE: 1

metaR r2371
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
is described by: ECO:0000000
reversible: true
reactant: MODEL1310110061#
fast: false
kinetic law: MODEL1310110061#
product: MODEL1310110061#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172 NOTES:
is: SBO:0000185
type: Reaction

metaM C05957 r
notes: FORMULA: C20H29O4 CHARGE: -1 INCHI: InChI=1S/C20H30O4/c1-2-3-6-10-17(21)13-14-18-16(12-15-19(18)22)9-7-4-5-8-11-20(23)24/h4,7,12-18,21H,2-3,5-6,8-11H2,1H3,(H,23,24)/b7-4-,14-13+/t16-,17-,18+/m0/s1 EHMN_ABBREVIATION: C05957
type: Species
boundary condition: false
initial amount: NaN
initial concentration: 1.0
has only substance units: false
name: Prostaglandin J2
is: CHEBI:27485
is: SBO:0000247
is: HMDB02710
constant: false

metaM dgtp c
constant: false
notes: FORMULA: C10H12N5O13P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00252 EHMN_ABBREVIATION: C00286
is: C00286
is: HMDB01440
is: SBO:0000247
is: CHEBI:16497
initial amount: NaN
has only substance units: false
type: Species
name: dGTP
initial concentration: 1.0
boundary condition: false

metaR PUNP7
reversible: true
fast: false
product: MODEL1310110061#
notes: GENE_ASSOCIATION: (4860.1) SUBSYSTEM: Nucleotide interconversion EC Number: 3.4.2.1 Confidence Level: 4 AUTHORS: PMID:6087295,PMID:9305963 NOTES:Specificity not completely determined. Can also catalyse ribosyltransferase reactions of the type catalysed by EC 2.4.2.5, nucleoside ribosyltransferasextsn
is described by: ECO:0000269
is: SBO:0000176
type: Reaction
name: purine-nucleoside phosphorylase (Xanthosine)
modifier: MODEL1310110061#
reactant: MODEL1310110061#
kinetic law: MODEL1310110061#
is version of: http://identifiers.org/ec-code/2.4.2.1

metaR EX tststerone LPAREN e RPAREN
kinetic law: MODEL1310110061#
reactant: MODEL1310110061#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Testosterone exchange
type: Reaction

metaR r0753
fast: false
reversible: true
is version of: http://identifiers.org/ec-code/2.3.1.85
type: Reaction
kinetic law: MODEL1310110061#
reactant: MODEL1310110061#
notes: GENE_ASSOCIATION: (2194.1) SUBSYSTEM: Unassigned EC Number: 1.2.1.5 Confidence Level: 0 AUTHORS: PMID:11790142,PMID:12604221 NOTES:
product: MODEL1310110061#
modifier: MODEL1310110061#
is: SBO:0000176
is described by: ECO:0000000
name: 3,4-Dihydroxymandelaldehyde:NADP+ oxidoreductase Tyrosine metabolism EC:1.2.1.5

http://identifiers.org/biomodels.db/MODEL1310110061#_2cb307e3_ae17_4b9a_aede_51da004f916a
is: SBO:0000252
has only substance units: false
boundary condition: true
type: Species
initial concentration: NaN
is encoded by: hsa:H45672
constant: false
initial amount: NaN
name: _H45672_1_m

metaR GCC2bim
kinetic law: MODEL1310110061#
name: glycine-cleavage system (lipoamide) irreversible, mitochondrial
fast: false
notes: GENE_ASSOCIATION: (275.1) and (1738.1) and (2731.1) and (2653.1) SUBSYSTEM: Glycine, serine, alanine and threonine metabolism EC Number: 1.8.1.4 Confidence Level: 4 AUTHORS: PMID:15355973 NOTES:NCD
is: SBO:0000176
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/1.8.1.4
modifier: MODEL1310110061#
product: MODEL1310110061#
type: Reaction
is version of: http://identifiers.org/ec-code/1.4.4.2
reactant: MODEL1310110061#
is version of: http://identifiers.org/ec-code/2.1.2.10
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110061#_abd5f2a9_d6fb_45e7_8776_48a86d95cf1f
name: FAH
boundary condition: true
is: P16930
constant: false
is encoded by: hsa:2184
initial amount: NaN
initial concentration: NaN
type: Species
is: SBO:0000252
has only substance units: false

metaM h2o2 c
initial concentration: 1.0
is: SBO:0000247
constant: false
is: HMDB03125
initial amount: NaN
notes: FORMULA: H2O2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00036 EHMN_ABBREVIATION: C00027
type: Species
is: CHEBI:16240
name: Hydrogen peroxide
boundary condition: false
is: C00027
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110061#_bb1b0593_dd1d_4eaa_b945_42fcc54800d9
has only substance units: false
name: FOLR1
constant: false
boundary condition: true
initial amount: NaN
initial concentration: NaN
is: SBO:0000252
type: Species
is encoded by: hsa:2348

http://identifiers.org/biomodels.db/MODEL1310110061#_185fc020_2ce6_4b78_b150_849b9ad360cc
initial concentration: NaN
name: PIP5K1B
constant: false
initial amount: NaN
boundary condition: true
type: Species
is encoded by: hsa:8395
has only substance units: false
is: O14986
is: SBO:0000252

metaM h c
is: http://identifiers.org/pubchem.compound/3380
is: SBO:0000247
initial concentration: 1.0
name: proton
constant: false
has only substance units: false
boundary condition: false
notes: FORMULA: H CHARGE: 1 INCHI: "
is: CHEBI:24636
is: C00080
initial amount: NaN
type: Species

http://identifiers.org/biomodels.db/MODEL1310110061#_c205dcd9_75d3_48d9_ab6c_d9a421c05dec
name: GLUD2
is encoded by: hsa:2747
initial concentration: NaN
is: SBO:0000252
boundary condition: true
has only substance units: false
initial amount: NaN
is: P49448
constant: false
type: Species

metaM ahcys e
is: SBO:0000247
initial amount: NaN
has only substance units: false
initial concentration: 1.0
is: CHEBI:16680
notes: FORMULA: C14H20N6O5S CHARGE: 0
boundary condition: false
is: C00021
is: HMDB00939
name: S-Adenosyl-L-homocysteine
constant: false
type: Species

metaR PI45P3K
product: MODEL1310110061#
name: phosphatidylinositol 4,5-bisphosphate 3-kinase
type: Reaction
is version of: http://identifiers.org/ec-code/2.7.1.153
reversible: false
fast: false
reactant: MODEL1310110061#
kinetic law: MODEL1310110061#
is version of: http://identifiers.org/ec-code/2.7.11.1
is described by: ECO:0000000
modifier: MODEL1310110061#
notes: GENE_ASSOCIATION: (5291.1 and 5295.3) or (5293.1 and 8503.1) or (5296.1 and 5290.1) or (5293.1 and 5295.1) or (5293.1 and 5295.3) or (5291.1 and 5295.1) or (5296.1 and 5291.1) or (5295.2 and 5290.1) or (10870.1 and 5294.1) or (23533.1 and 5294.1) or (5295.2 and 5293.1) or (5290.1 and 5295.1) or (5290.1 and 8503.1) or (5290.1 and 5295.3) or (5291.1 and 8503.1) or (5293.1 and 5296.1) or (5295.2 and 5291.1) SUBSYSTEM: Inositol phosphate metabolism EC Number: 2.7.1.153 Confidence Level: 4 AUTHORS: PMID:12507995,PMID:15780590,PMID:2174051,PMID:7624799,PMID:7713498,PMID:8246984,PMID:9113989 NOTES:NCD
is: SBO:0000176

metaR r2420
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:10585886,PMID:14598172,PMID:4424886,PMID:4441366,PMID:5099217,PMID:8329439 NOTES:
fast: false
type: Reaction
kinetic law: MODEL1310110061#
is: SBO:0000185
reactant: MODEL1310110061#
name: Mitochondrial Carrier (MC) TCDB:2.A.29.2.7
product: MODEL1310110061#
reversible: true

metaR EX inost LPAREN e RPAREN
kinetic law: MODEL1310110061#
reactant: MODEL1310110061#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: myo-Inositol exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110061#_5ca1fa79_6fee_435f_9ced_954998feebc9
constant: false
is: SBO:0000252
boundary condition: true
is: P13686
type: Species
has only substance units: false
initial amount: NaN
is encoded by: hsa:54
initial concentration: NaN
name: ACP5

http://identifiers.org/biomodels.db/MODEL1310110061#_e745820a_4736_4c1c_bd3b_6292dea82350
has only substance units: false
initial concentration: NaN
initial amount: NaN
type: Species
is: Q9BQG2
name: NUDT12
constant: false
boundary condition: true
is: SBO:0000252
is encoded by: hsa:83594

http://identifiers.org/biomodels.db/MODEL1310110061#_1f67942d_532d_4ec8_ad23_6b6213008311
is encoded by: hsa:9468
name: PCYT1B
has only substance units: false
initial concentration: NaN
initial amount: NaN
is: SBO:0000252
is: E9PD84
constant: false
type: Species
boundary condition: true

metaR r0752
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (30.1) or (10449.1) or (3032.1) or (4645.1) SUBSYSTEM: Unassigned EC Number: 1.2.1.5 Confidence Level: 0 AUTHORS: PMID:10424772,PMID:11958479,PMID:3466164 NOTES:
name: 3,4-Dihydroxymandelaldehyde:NAD+ oxidoreductase Tyrosine metabolism EC:1.2.1.5
modifier: MODEL1310110061#
reversible: true
type: Reaction
is version of: http://identifiers.org/ec-code/2.3.1.16
kinetic law: MODEL1310110061#
reactant: MODEL1310110061#
product: MODEL1310110061#
fast: false
is: SBO:0000176

metaM duri n
initial concentration: 1.0
notes: FORMULA: C9H12N2O5 CHARGE: 0 INCHI: InChI=1S/C9H12N2O5/c12-4-6-5(13)3-8(16-6)11-2-1-7(14)10-9(11)15/h1-2,5-6,8,12-13H,3-4H2,(H,10,14,15)/t5-,6+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00410 EHMN_ABBREVIATION: C00526
is: CHEBI:16450
initial amount: NaN
name: 2'-deoxyuridine
has only substance units: false
constant: false
is: SBO:0000247
boundary condition: false
is: HMDB00012
type: Species

metaR CYTK3n
fast: false
type: Reaction
reversible: true
is version of: http://identifiers.org/ec-code/2.7.4.14
modifier: MODEL1310110061#
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
product: MODEL1310110061#
name: cytidylate kinase (dCMP,CTP),nuclear
kinetic law: MODEL1310110061#
is: SBO:0000176
is described by: ECO:0000269
reactant: MODEL1310110061#

metaM mi34p c
constant: false
is: SBO:0000247
initial amount: NaN
type: Species
boundary condition: false
name: 1D-myo-Inositol 3,4-bisphosphate
is: CHEBI:28858
is: HMDB06235
initial concentration: 1.0
has only substance units: false
notes: FORMULA: C6H10O12P2 CHARGE: -4 INCHI: InChI=1S/C6H14O12P2/c7-1-2(8)4(10)6(18-20(14,15)16)5(3(1)9)17-19(11,12)13/h1-10H,(H2,11,12,13)(H2,14,15,16)/t1-,2-,3-,4+,5-,6-/m0/s1 EHMN_ABBREVIATION: C04063

http://identifiers.org/biomodels.db/MODEL1310110061#_5a9b3cca_8ced_4035_be47_e136f677eaab
name: UPB1
initial amount: NaN
is: B3KNC1
is encoded by: hsa:51733
boundary condition: true
has only substance units: false
initial concentration: NaN
is: SBO:0000252
constant: false
type: Species

metaR EX lneldc LPAREN e RPAREN
kinetic law: MODEL1310110061#
reactant: MODEL1310110061#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: linoelaidic acid exchange
type: Reaction

metaM q10h2 e
initial amount: NaN
constant: false
type: Species
is: SBO:0000247
has only substance units: false
name: Ubiquinol-10
is: HMDB13111
notes: FORMULA: C59H92O4 CHARGE: 0 INCHI: InChI=1/C59H92O4/c1-44(2)24-15-25-45(3)26-16-27-46(4)28-17-29-47(5)30-18-31-48(6)32-19-33-49(7)34-20-35-50(8)36-21-37-51(9)38-22-39-52(10)40-23-41-53(11)42-43-55-54(12)56(60)58(62-13)59(63-14)57(55)61/h24,26,28,30,32,34,36,38,40,42,60-61H,15-23,25,27,29,31,33,35,37,39,41,43H2,1-14H3/b45-26+,46-28+,47-30+,48-32+,49-34+,50-36+,51-38+,52-40+,53-42+
is: http://identifiers.org/pubchem.compound/6504740
initial concentration: 1.0
boundary condition: false

metaR FAOXC122C101m
kinetic law: MODEL1310110061#
product: MODEL1310110061#
reactant: MODEL1310110061#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C12:2-->C10:1)m
type: Reaction

metaR PSt3
is described by: ECO:0000269
type: Reaction
name: phosphatidylserine transport
product: MODEL1310110061#
reactant: MODEL1310110061#
is: SBO:0000185
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: 2.7.8.8 Confidence Level: 2 AUTHORS: NOTES:
kinetic law: MODEL1310110061#
fast: false

metaR RE3245C
name: RE3245
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:0 NOTES:IT - fixed proton
kinetic law: MODEL1310110061#
product: MODEL1310110061#
reactant: MODEL1310110061#
fast: false
is: SBO:0000176
type: Reaction
is described by: ECO:0000000
reversible: true

metaM leuktrD4 e
boundary condition: false
constant: false
is: SBO:0000247
is: CHEBI:28666
initial amount: NaN
name: Leukotriene D4
notes: FORMULA: C25H39N2O6S CHARGE: -1 INCHI: InChI=1S/C25H40N2O6S/c1-2-3-4-5-6-7-8-9-10-11-12-13-16-22(21(28)15-14-17-23(29)30)34-19-20(26)25(33)27-18-24(31)32/h6-7,9-13,16,20-22,28H,2-5,8,14-15,17-19,26H2,1H3,(H,27,33)(H,29,30)(H,31,32)/b7-6-,10-9-,12-11+,16-13+/t20-,21-,22+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01664 EHMN_ABBREVIATION: C05951
is: HMDB03080
initial concentration: 1.0
type: Species
has only substance units: false

metaR CYSGLTH
is described by: ECO:0000000
fast: false
product: MODEL1310110061#
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Methionine and cysteine metabolism EC Number: 1.8.4.4 Confidence Level: 4 AUTHORS: PMID:15189131,PMID:932033 NOTES:reaction according to KEGG MM
name: Glutathione:cystine oxidoreductase
reactant: MODEL1310110061#
is: SBO:0000176
kinetic law: MODEL1310110061#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110061#_78902fa3_8cf2_40d5_ad91_2fa990d1994c
is: GO:0005783
is: SBO:0000290
constant: false
size: 1.0
spatial dimensions: 3.0
name: endoplasmic reticulum
type: Compartment

http://identifiers.org/biomodels.db/MODEL1310110061#_f2ce7b09_e02e_47ad_87ca_e112a3d64cb2
initial amount: NaN
is: SBO:0000252
constant: false
initial concentration: NaN
is encoded by: hsa:10588
name: MTHFS
boundary condition: true
is: P49914
type: Species
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110061#_0cd6e72e_f955_4676_8d9b_167025188844
has only substance units: false
constant: false
initial amount: NaN
boundary condition: true
is: P35219
is: SBO:0000252
is encoded by: hsa:767
type: Species
initial concentration: NaN
name: CA8

metaR r0744
type: Reaction
fast: false
reactant: MODEL1310110061#
notes: GENE_ASSOCIATION: SUBSYSTEM: Bile acid synthesis EC Number: 4.2.1.107 Confidence Level: 0 AUTHORS: PMID:11330072 NOTES:
is: SBO:0000176
name: (24R,25R)-3alpha,7alpha,12alpha,24-tetrahydroxy-5beta-cholestanoyl- CoA hydro-lyase Bile acid biosynthesis EC:4.2.1.107
product: MODEL1310110061#
reversible: false
is described by: ECO:0000000
kinetic law: MODEL1310110061#

metaR r0638
fast: false
name: trans-Dodec-2-enoyl-CoA reductase Fatty acid elongation in mitochondria EC:1.3.1.38
is: SBO:0000176
kinetic law: MODEL1310110061#
modifier: MODEL1310110061#
reactant: MODEL1310110061#
reversible: true
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/2.8.1.2
notes: GENE_ASSOCIATION: (4357.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.1.38 Confidence Level: 0 AUTHORS: PMID:12654921 NOTES:
product: MODEL1310110061#
type: Reaction

metaR EX dgchol LPAREN e RPAREN
kinetic law: MODEL1310110061#
reactant: MODEL1310110061#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Chenodeoxyglycocholate exchange
type: Reaction

metaR FUT12g
name: Galactoside 2-alpha-L-fucosyltransferase 1
modifier: MODEL1310110061#
product: MODEL1310110061#
is version of: http://identifiers.org/ec-code/2.4.1.69
type: Reaction
kinetic law: MODEL1310110061#
reactant: MODEL1310110061#
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (2523.1) SUBSYSTEM: Blood group synthesis EC Number: 2.4.1.69 Confidence Level: 4 AUTHORS: PMID:2118655 NOTES:NJ
fast: false
is: SBO:0000176
reversible: false

metaR EX tethex3 LPAREN e RPAREN
kinetic law: MODEL1310110061#
reactant: MODEL1310110061#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: tetracosahexaenoic acid, n-3 exchange
type: Reaction

metaR SUCD1m
notes: GENE_ASSOCIATION: (6389.1 and 6392.1 and 6391.1 and 6390.1) SUBSYSTEM: Citric acid cycle EC Number: 1.3.99.1 Confidence Level: 0 AUTHORS: PMID:6945861 NOTES:NCD. Biochemical, Genetic
product: MODEL1310110061#
type: Reaction
is version of: http://identifiers.org/ec-code/1.3.5.1
kinetic law: MODEL1310110061#
reversible: true
modifier: MODEL1310110061#
is: SBO:0000176
reactant: MODEL1310110061#
name: succinate dehydrogenase
is described by: ECO:0000134
fast: false

metaM malthp e
is: C01936
initial concentration: 1.0
name: maltoheptaose
type: Species
constant: false
boundary condition: false
is: SBO:0000247
is: http://identifiers.org/pubchem.compound/5041
initial amount: NaN
has only substance units: false
notes: FORMULA: C42H72O36 CHARGE: 0 INCHI: InChI=1/C42H72O36/c43-1-8-15(50)16(51)24(59)37(67-8)74-31-10(3-45)69-39(26(61)18(31)53)76-33-12(5-47)71-41(28(63)20(33)55)78-35-14(7-49)72-42(29(64)22(35)57)77-34-13(6-48)70-40(27(62)21(34)56)75-32-11(4-46)68-38(25(60)19(32)54)73-30-9(2-44)66-36(65)23(58)17(30)52/h8-65H,1-7H2/t8-,9-,10-,11-,12-,13-,14-,15+,16+,17-,18-,19-,20-,21-,22-,23+,24+,25+,26+,27+,28+,29+,30+,31+,32+,33+,34+,35+,36u,37+,38+,39+,40+,41+,42+/m1/s1 EHMN_ABBREVIATION: CE2837

metaR EX ctp LPAREN e RPAREN
kinetic law: MODEL1310110061#
reactant: MODEL1310110061#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of CTP(4-)
type: Reaction

metaM glyphe e
initial concentration: 1.0
initial amount: NaN
type: Species
notes: FORMULA: C11H14N2O3 CHARGE: 0
name: Glycylphenylalanine
constant: false
is: http://identifiers.org/pubchem.compound/97415
is: SBO:0000247
boundary condition: false
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110061#_ad9ee2f4_b5a7_4b9a_9048_25ea9012db4e
has only substance units: false
boundary condition: true
constant: false
initial concentration: NaN
is: Q0VAA5
type: Species
initial amount: NaN
name: PLCXD2
is encoded by: hsa:257068
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110061#_ba4c1ce6_efc3_4dc9_946f_e0b199a90fad
initial concentration: NaN
constant: false
boundary condition: true
type: Species
has only substance units: false
is encoded by: hsa:51079
is: Q9P0J0
initial amount: NaN
name: NDUFA13
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110061#_e9a99a46_67cd_420f_a26b_287435c23196
initial amount: NaN
has only substance units: false
name: HSD17B10
type: Species
initial concentration: NaN
is encoded by: hsa:3028
boundary condition: true
is: Q99714
constant: false
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110061#_038ea8c9_a2e5_49fc_89ab_00613012c5ae
is: SBO:0000252
is encoded by: hsa:AI291895
initial amount: NaN
boundary condition: true
constant: false
type: Species
has only substance units: false
name: _AI291895_1_c
initial concentration: NaN

metaM C02528 c
initial concentration: 1.0
is: CHEBI:36234
is: SBO:0000247
constant: false
name: chenodeoxycholate
has only substance units: false
initial amount: NaN
is: HMDB00518
type: Species
boundary condition: false
notes: FORMULA: C24H39O4 CHARGE: -1 INCHI: InChI=1S/C24H40O4/c1-14(4-7-21(27)28)17-5-6-18-22-19(9-11-24(17,18)3)23(2)10-8-16(25)12-15(23)13-20(22)26/h14-20,22,25-26H,4-13H2,1-3H3,(H,27,28)/p-1/t14-,15+,16-,17-,18+,19+,20-,22+,23+,24-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00958 EHMN_ABBREVIATION: C02528

metaR EX so4 LPAREN e RPAREN
kinetic law: MODEL1310110061#
reactant: MODEL1310110061#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Sulfate exchange
type: Reaction

metaR EX orot LPAREN e RPAREN
kinetic law: MODEL1310110061#
reactant: MODEL1310110061#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of orotate
type: Reaction

metaR RE1233C
is described by: ECO:0000000
reversible: true
fast: false
kinetic law: MODEL1310110061#
notes: GENE_ASSOCIATION: (883.1) SUBSYSTEM: Tryptophan metabolism EC Number: 2.6.1.7 Confidence Level: 0 AUTHORS: PMID:10756023 NOTES:IT - removed H[c] on right hand side
type: Reaction
reactant: MODEL1310110061#
is: SBO:0000176
modifier: MODEL1310110061#
is version of: http://identifiers.org/ec-code/2.6.1.64
product: MODEL1310110061#
name: RE1233