metaR r0679
is described by: ECO:0000000
reactant: MODEL1310110045#
name: ATP:pantothenate 4-phosphotransferase Pantothenate and CoA biosynthesis EC:2.7.1.33
notes: GENE_ASSOCIATION: (30.1) or (10449.1) or (3032.1) or (4645.1) SUBSYSTEM: CoA catabolism EC Number: 2.7.1.33 Confidence Level: 0 AUTHORS: PMID:10625688,PMID:13630913,PMID:15105273,PMID:15659606,PMID:16040613 NOTES:
type: Reaction
is version of: http://identifiers.org/ec-code/2.3.1.16
kinetic law: MODEL1310110045#
modifier: MODEL1310110045#
product: MODEL1310110045#
fast: false
reversible: true
is: SBO:0000176

metaR UMPK7
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
modifier: MODEL1310110045#
reversible: true
name: UMP kinase (dGTP)
product: MODEL1310110045#
fast: false
is version of: http://identifiers.org/ec-code/2.7.4.14
type: Reaction
is described by: ECO:0000269
is: SBO:0000176
kinetic law: MODEL1310110045#
reactant: MODEL1310110045#

metaR VALTA
kinetic law: MODEL1310110045#
is described by: ECO:0000269
is: SBO:0000176
product: MODEL1310110045#
modifier: MODEL1310110045#
name: valine transaminase
type: Reaction
reactant: MODEL1310110045#
fast: false
notes: GENE_ASSOCIATION: (586.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 2.6.1.42 Confidence Level: 4 AUTHORS: PMID:6933702,PMID:9165094 NOTES:
reversible: true
is version of: http://identifiers.org/ec-code/2.6.1.42

metaR NDPK8n
reactant: MODEL1310110045#
modifier: MODEL1310110045#
is version of: http://identifiers.org/ec-code/2.7.4.6
reversible: true
is described by: ECO:0000304
notes: GENE_ASSOCIATION: (4831.1 and 4830.1) or (4830.2 and 4831.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.6 Confidence Level: 4 AUTHORS: PMID:7050910 NOTES:Many nucleoside diphosphates (eight described) can act as acceptors. While many ribo- and deoxyribonucleoside triphosphates can act as donors, only ATP is chosen as a donor to minimize the number of total reactions.. Presence in the nucleus
type: Reaction
kinetic law: MODEL1310110045#
name: nucleoside-diphosphate kinase (ATP:dADP), nuclear
product: MODEL1310110045#
is: SBO:0000176
fast: false

http://identifiers.org/biomodels.db/MODEL1310110045#_0bd3885a_5798_4c08_8669_7adc705745e0
is: P17516
boundary condition: true
initial amount: NaN
name: AKR1C4
initial concentration: NaN
is encoded by: hsa:1109
type: Species
constant: false
has only substance units: false
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110045#_a40aaac4_2851_4cf2_8f3e_1958b3eae2f3
is: SBO:0000252
initial amount: NaN
has only substance units: false
is encoded by: hsa:29085
constant: false
name: PHPT1
initial concentration: NaN
is: Q9P019
boundary condition: true
type: Species

metaM sgalside hs g
boundary condition: false
is: SBO:0000247
constant: false
is: HMDB00061
initial concentration: 1.0
name: sulfatide galactocerebroside
has only substance units: false
type: Species
is: CHEBI:58343
notes: FORMULA: C24H45NO10SFULLRCO CHARGE: -1
initial amount: NaN

metaR ARABR
reversible: false
kinetic law: MODEL1310110045#
reactant: MODEL1310110045#
fast: false
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/1.1.1.21
type: Reaction
product: MODEL1310110045#
is: SBO:0000176
name: arabinose reductase
is version of: http://identifiers.org/ec-code/1.1.1.2
notes: GENE_ASSOCIATION: (10327.2) or (8574.1) or (10327.1) or (231.1) SUBSYSTEM: Pentose phosphate pathway EC Number: 1.1.1.21 Confidence Level: 4 AUTHORS: PMID:12071861,PMID:12359133,PMID:15234337,PMID:9823300 NOTES:
modifier: MODEL1310110045#

metaR EX fru LPAREN e RPAREN
kinetic law: MODEL1310110045#
reactant: MODEL1310110045#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for D-Fructose
type: Reaction

metaM omhpal r
initial concentration: 1.0
is: HMDB06294
initial amount: NaN
name: w-hydroxypalmiticacid
is: SBO:0000247
type: Species
boundary condition: false
has only substance units: false
notes: FORMULA: C16H30O3 CHARGE: -1
constant: false

metaR UMPK6
reactant: MODEL1310110045#
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
type: Reaction
product: MODEL1310110045#
is version of: http://identifiers.org/ec-code/2.7.4.14
is: SBO:0000176
fast: false
modifier: MODEL1310110045#
name: UMP kinase (dCTP)
kinetic law: MODEL1310110045#
reversible: true
is described by: ECO:0000269

metaR THP2Ctp
product: MODEL1310110045#
is: SBO:0000185
kinetic law: MODEL1310110045#
reactant: MODEL1310110045#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 1 AUTHORS: NOTES:MM
reversible: true
name: 2,3,4,5-Tetrahydropyridine-2-carboxylate transport, peroxisomal
is described by: ECO:0000000
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110045#_a3f0f49c_452a_411a_876f_5e469e8c18e3
initial concentration: NaN
type: Species
is: SBO:0000252
initial amount: NaN
has only substance units: false
boundary condition: true
name: SLC5A3
is encoded by: hsa:6526
is: P53794
constant: false

http://identifiers.org/biomodels.db/MODEL1310110045#_84c4599d_4715_459a_b2ed_ad49b808d27b
is encoded by: hsa:AA081045
initial amount: NaN
constant: false
is: SBO:0000252
boundary condition: true
initial concentration: NaN
name: _AA081045_1_c
has only substance units: false
type: Species

metaR EX C05965 LPAREN e RPAREN
kinetic law: MODEL1310110045#
reactant: MODEL1310110045#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 12(S)-HPETE(1-) exchange
type: Reaction

metaM c226coa x
has only substance units: false
name: cervonyl coenzyme A
constant: false
is: http://identifiers.org/pubchem.compound/47205479
notes: FORMULA: C43H62N7O17P3S CHARGE: -4 INCHI: InChI=1/C43H66N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-34(52)71-27-26-45-33(51)24-25-46-41(55)38(54)43(2,3)29-64-70(61,62)67-69(59,60)63-28-32-37(66-68(56,57)58)36(53)42(65-32)50-31-49-35-39(44)47-30-48-40(35)50/h5-6,8-9,11-12,14-15,17-18,20-21,30-32,36-38,42,53-54H,4,7,10,13,16,19,22-29H2,1-3H3,(H,45,51)(H,46,55)(H,59,60)(H,61,62)(H2,44,47,48)(H2,56,57,58)/b6-5-,9-8-,12-11-,15-14-,18-17-,21-20-/t32-,36-,37-,38?,42-/m1/s1
type: Species
boundary condition: false
initial concentration: 1.0
is: C16169
initial amount: NaN
is: SBO:0000247

metaR O2tp
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD
product: MODEL1310110045#
reactant: MODEL1310110045#
kinetic law: MODEL1310110045#
name: O2 transport, peroxisomal
fast: false
reversible: true
is: SBO:0000185
is described by: ECO:0000000
type: Reaction

metaR EX prostgd2 LPAREN e RPAREN
kinetic law: MODEL1310110045#
reactant: MODEL1310110045#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Prostaglandin D2 exchange
type: Reaction

metaR SARCStm
kinetic law: MODEL1310110045#
product: MODEL1310110045#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 1 AUTHORS: NOTES:MM
is: SBO:0000185
is described by: ECO:0000000
fast: false
type: Reaction
reactant: MODEL1310110045#
reversible: false
name: Sarcosine transport (mitochondrial)

http://identifiers.org/biomodels.db/MODEL1310110045#_e9699712_c9db_4d20_be28_e79724a39a7a
is: P31937
is: SBO:0000252
initial concentration: NaN
name: HIBADH
constant: false
is encoded by: hsa:11112
initial amount: NaN
type: Species
boundary condition: true
has only substance units: false

metaM s7p c
has only substance units: false
is: CHEBI:57483
initial concentration: 1.0
is: SBO:0000247
boundary condition: false
constant: false
name: Sedoheptulose 7-phosphate
notes: FORMULA: C7H13O10P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC01436 EHMN_ABBREVIATION: C05382
type: Species
is: C05382
initial amount: NaN
is: HMDB01068

metaR r2471
is described by: ECO:0000000
type: Reaction
reactant: MODEL1310110045#
name: Major Facilitator(MFS) TCDB:2.A.18.8.1
fast: false
kinetic law: MODEL1310110045#
reversible: false
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12748860 NOTES:
product: MODEL1310110045#

http://identifiers.org/biomodels.db/MODEL1310110045#_49f33845_8094_4c78_87c8_f4e6ca7e7584
name: SULT1A2
initial amount: NaN
has only substance units: false
initial concentration: NaN
boundary condition: true
type: Species
is encoded by: hsa:6799
is: SBO:0000252
constant: false

metaR ITPtn
reversible: true
fast: false
is: SBO:0000185
reactant: MODEL1310110045#
kinetic law: MODEL1310110045#
product: MODEL1310110045#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: NOTES:IT
type: Reaction
name: ITP nuclear transport

metaR TREHe
kinetic law: MODEL1310110045#
reversible: false
type: Reaction
reactant: MODEL1310110045#
product: MODEL1310110045#
modifier: MODEL1310110045#
is version of: http://identifiers.org/ec-code/3.2.1.28
notes: GENE_ASSOCIATION: (11181.1) SUBSYSTEM: Starch and sucrose metabolism EC Number: 3.2.1.28 Confidence Level: 4 AUTHORS: PMID:12065209,PMID:9427547 NOTES:JLR
name: alpha,alpha-trehalase
is: SBO:0000176
is described by: ECO:0000269
fast: false

http://identifiers.org/biomodels.db/MODEL1310110045#_c1f49462_8055_467f_89c5_50ca1a8d7520
is: Q9NUB1
initial amount: NaN
name: ACSS1
type: Species
is: SBO:0000252
boundary condition: true
has only substance units: false
constant: false
initial concentration: NaN
is encoded by: hsa:84532

http://identifiers.org/biomodels.db/MODEL1310110045#_2c89abf5_8a0b_42b3_a3d5_efca18bfdd64
boundary condition: true
is: SBO:0000252
is encoded by: hsa:2954
initial amount: NaN
is: A6NED0
constant: false
has only substance units: false
type: Species
initial concentration: NaN
name: GSTZ1

metaR UDPACGALtl
reversible: true
type: Reaction
is described by: ECO:0000000
name: udpacgal intracellular transport
reactant: MODEL1310110045#
kinetic law: MODEL1310110045#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 1 AUTHORS: NOTES:unknown mechanism for transport - there are UDPACGAL-translocators for ER and Golgi, however no info on lysosomal - poor support for this NJ
is: SBO:0000185
product: MODEL1310110045#
fast: false

metaR r0443
type: Reaction
product: MODEL1310110045#
notes: GENE_ASSOCIATION: (AI971036.1) or (3417.1) or (3418.1) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.21 Confidence Level: 0 AUTHORS: PMID:1735445,PMID:1988962,PMID:2355017,PMID:6361812,PMID:7892212 NOTES:
fast: false
name: Palmitoyl-CoA:L-carnitine O-palmitoyltransferase Fatty acid metabolism EC:2.3.1.21
is: SBO:0000176
kinetic law: MODEL1310110045#
reversible: false
reactant: MODEL1310110045#
modifier: MODEL1310110045#
is version of: http://identifiers.org/ec-code/1.1.1.42
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110045#_5b9de10f_8b5d_400d_8c4c_ac020dc2f813
is encoded by: hsa:3420
initial amount: NaN
constant: false
boundary condition: true
is: SBO:0000252
is: O43837
name: IDH3B
initial concentration: NaN
type: Species
has only substance units: false

metaR FRDPtcr
type: Reaction
reversible: true
product: MODEL1310110045#
name: transport of Farnesyl diphosphate into the endoplasmic reticulum
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: required for cholesterol synthesis in E.R. NOTES:required for cholesterol synthesis in E.R.
is described by: ECO:0000134
kinetic law: MODEL1310110045#
fast: false
reactant: MODEL1310110045#

http://identifiers.org/biomodels.db/MODEL1310110045#_c92f321a_c68c_49b2_b92e_078258e38ed7
is: SBO:0000252
has only substance units: false
type: Species
initial concentration: NaN
boundary condition: true
initial amount: NaN
constant: false
name: PDE8A
is encoded by: hsa:5151

metaM CE2705 n
name: quinonoid dihydrobiopterin
is: SBO:0000247
initial amount: NaN
initial concentration: 1.0
boundary condition: false
type: Species
has only substance units: false
notes: FORMULA: C9H13N5O3 CHARGE: 0 INCHI: InChI=1/C9H13N5O3/c1-3(15)6(16)4-2-11-7-5(12-4)8(17)14-9(10)13-7/h3-4,6,15-16H,2H2,1H3,(H3,10,11,13,14,17)/p+1/t3-,4?,6+/m0/s1 EHMN_ABBREVIATION: CE2705
constant: false
is: CHEBI:15374
is: HMDB02281

http://identifiers.org/biomodels.db/MODEL1310110045#_d20bb42f_c8f1_4844_b81d_e3c02dfd10cf
initial concentration: NaN
is encoded by: hsa:10195
name: ALG3
type: Species
has only substance units: false
constant: false
boundary condition: true
initial amount: NaN
is: SBO:0000252

metaR KCCt
is: SBO:0000185
fast: false
is described by: ECO:0000269
name: K+-Cl- cotransport
type: Reaction
modifier: MODEL1310110045#
notes: GENE_ASSOCIATION: (10723.1) or (57468.1) or (9990.1) or (6560.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10187864,PMID:10347194,PMID:10600773,PMID:121106695,PMID:12657561,PMID:12739168,PMID:8663127 NOTES:NCD
reactant: MODEL1310110045#
product: MODEL1310110045#
kinetic law: MODEL1310110045#
reversible: true

metaR AMETt2m
product: MODEL1310110045#
modifier: MODEL1310110045#
reactant: MODEL1310110045#
name: S-Adenosyl-L-methionine reversible transport, mitochondrial
reversible: true
fast: false
is described by: ECO:0000269
is: SBO:0000185
type: Reaction
kinetic law: MODEL1310110045#
notes: GENE_ASSOCIATION: (115286.3) or (115286.2) or (115286.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14674884 NOTES:Added by RS/TV (6/17/05)

metaR PHACCOAGLNAC
is described by: ECO:0000000
name: Phenylacetyl-CoA:L-glutamine alpha-N-phenylacetyltransferase
fast: false
type: Reaction
is: SBO:0000176
reactant: MODEL1310110045#
reversible: false
product: MODEL1310110045#
kinetic law: MODEL1310110045#
notes: GENE_ASSOCIATION: SUBSYSTEM: Phenylalanine metabolism EC Number: 2.3.1.14 Confidence Level: 2 AUTHORS: NOTES:SAB

metaM dha e
is: SBO:0000247
initial concentration: 1.0
type: Species
name: glycerone
notes: FORMULA: C3H6O3 CHARGE: 0 INCHI: InChI=1S/C3H6O3/c4-1-3(6)2-5/h4-5H,1-2H2 HEPATONET_1.0_ABBREVIATION: HC00175 EHMN_ABBREVIATION: C00184
has only substance units: false
initial amount: NaN
is: HMDB01882
constant: false
boundary condition: false
is: CHEBI:16016

metaM sgalside hs l
name: sulfatide galactocerebroside
constant: false
notes: FORMULA: C24H45NO10SFULLRCO CHARGE: -1
is: CHEBI:16349
initial concentration: 1.0
is: SBO:0000247
is: HMDB00904
initial amount: NaN
has only substance units: false
type: Species
boundary condition: false

metaR r2368
name: Organic anion transporter 5 Utilized transport
is described by: ECO:0000000
reactant: MODEL1310110045#
type: Reaction
is: SBO:0000185
product: MODEL1310110045#
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
kinetic law: MODEL1310110045#
fast: false

http://identifiers.org/biomodels.db/MODEL1310110045#_2bb9f698_fd2a_4cab_884f_b99b0399a16c
has only substance units: false
type: Species
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:5286
constant: false
name: PIK3C2A
initial concentration: NaN
is: O00443
boundary condition: true

metaR DHCRD1
reactant: MODEL1310110045#
notes: GENE_ASSOCIATION: (8560.1) or (8560.2) SUBSYSTEM: Sphingolipid metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:9188692 NOTES:NJ
fast: false
product: MODEL1310110045#
reversible: false
modifier: MODEL1310110045#
is described by: ECO:0000269
type: Reaction
kinetic law: MODEL1310110045#
is: SBO:0000176
name: dihydroceramide desaturase

http://identifiers.org/biomodels.db/MODEL1310110045#_1c8e5413_7192_4b00_8fff_aa2be10bfebd
is: Q96BD0
has only substance units: false
constant: false
initial concentration: NaN
boundary condition: true
name: SLCO4A1
initial amount: NaN
is: SBO:0000252
is encoded by: hsa:28231
type: Species

metaM mal L e
has only substance units: false
notes: FORMULA: C4H4O5 CHARGE: -2 INCHI: InChI=1S/C4H6O5/c5-2(4(8)9)1-3(6)7/h2,5H,1H2,(H,6,7)(H,8,9)/p-2/t2-/m0/s1
is: CHEBI:15589
is: HMDB00156
initial amount: NaN
name: (S)-malate(2-)
type: Species
initial concentration: 1.0
is: SBO:0000247
boundary condition: false
constant: false

metaM Rtotal2 c
is: C00055
boundary condition: false
name: R total 2 position
initial amount: NaN
type: Species
is: CHEBI:60377
notes: FORMULA: CO2FULLR2 CHARGE: -1
has only substance units: false
is: SBO:0000247
constant: false
initial concentration: 1.0
is: HMDB00095

http://identifiers.org/biomodels.db/MODEL1310110045#_93d7a4e8_18f0_4dcd_8e63_bbb5d34e961f
is: SBO:0000252
is: Q9NR34
type: Species
name: MAN1C1
has only substance units: false
boundary condition: true
is encoded by: hsa:57134
initial amount: NaN
initial concentration: NaN
constant: false

metaR GMPR
kinetic law: MODEL1310110045#
is: SBO:0000176
is described by: ECO:0000269
product: MODEL1310110045#
fast: false
name: GMP reductase
type: Reaction
notes: GENE_ASSOCIATION: (2766.1) or (51292.1) or (51292.3) or (51292.2) SUBSYSTEM: Nucleotide interconversion EC Number: 1.7.1.7 Confidence Level: 4 AUTHORS: PMID:12009299,PMID:8188226 NOTES:
reversible: false
is version of: http://identifiers.org/ec-code/1.7.1.7
modifier: MODEL1310110045#
reactant: MODEL1310110045#

metaR GLCNACT L
name: UDP-GlcNAc:N-acetyl-D-glucosaminyl diphosphodolichol N-acetyl-D-glucosaminyltransferase (liver)
product: MODEL1310110045#
fast: false
reversible: false
type: Reaction
is described by: ECO:0000000
kinetic law: MODEL1310110045#
is: SBO:0000176
reactant: MODEL1310110045#
notes: GENE_ASSOCIATION: SUBSYSTEM: N-glycan synthesis EC Number: 2.4.1.141 Confidence Level: 0 AUTHORS: NOTES:

http://identifiers.org/biomodels.db/MODEL1310110045#_5c02f6c7_f4bf_49c8_9194_3261c537b836
is: SBO:0000252
name: NAE1
initial amount: NaN
constant: false
type: Species
has only substance units: false
is encoded by: hsa:8883
initial concentration: NaN
boundary condition: true
is: A8MU28

metaM m4masn g
boundary condition: false
initial amount: NaN
type: Species
notes: FORMULA: C46H77N2O35X CHARGE: 0
has only substance units: false
is: SBO:0000247
initial concentration: 1.0
name: (alpha-D-mannosyl)4-beta-D-mannosyl-diacetylchitobiosyl-L-asparagine (protein)
constant: false
is: C05881

metaR GLNtm
reactant: MODEL1310110045#
type: Reaction
is: SBO:0000185
fast: false
kinetic law: MODEL1310110045#
reversible: false
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: NOTES:TV (6/7/2005) Study in rat liver (Soboll, 1991)
product: MODEL1310110045#
name: L-glutamine transport via electroneutral transporter

http://identifiers.org/biomodels.db/MODEL1310110045#_265b00a1_2f77_41c8_b5d7_c9b2fe3d996e
boundary condition: true
initial amount: NaN
constant: false
is: C9JT23
has only substance units: false
is: SBO:0000252
is encoded by: hsa:126328
type: Species
name: NDUFA11
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110045#_a0ef363c_6e6b_4b08_ab5c_239b09e91270
is: Q9NSW9
is: SBO:0000252
constant: false
boundary condition: true
is encoded by: hsa:6553
has only substance units: false
initial concentration: NaN
initial amount: NaN
type: Species
name: SLC9A5

metaR r2369
fast: false
is described by: ECO:0000000
name: Organic anion transporter 5 Utilized transport
reversible: true
kinetic law: MODEL1310110045#
product: MODEL1310110045#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
reactant: MODEL1310110045#
is: SBO:0000185
type: Reaction

metaM nm2masn g
type: Species
initial concentration: 1.0
notes: FORMULA: C42H70N3O30X CHARGE: 0
boundary condition: false
is: C05884
is: SBO:0000247
name: (N-acetyl-D-glucosaminyl-(alpha-D-mannosyl)2-beta-D-mannosyl-diacetylchitobiosyl)-L-asparagine (protein)
constant: false
initial amount: NaN
has only substance units: false

metaM glyald m
initial amount: NaN
is: SBO:0000247
initial concentration: 1.0
type: Species
is: CHEBI:17378
notes: FORMULA: C3H6O3 CHARGE: 0 INCHI: InChI=1S/C3H6O3/c4-1-3(6)2-5/h1,3,5-6H,2H2/t3-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00436 EHMN_ABBREVIATION: C00577
is: HMDB01051
name: D-glyceraldehyde
boundary condition: false
has only substance units: false
constant: false

metaR BILIRUBt2
type: Reaction
reversible: true
kinetic law: MODEL1310110045#
is described by: ECO:0000269
reactant: MODEL1310110045#
modifier: MODEL1310110045#
name: bilirubin transport via bicarbonate countertransport
notes: GENE_ASSOCIATION: (10599.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10358072,PMID:12507753,PMID:9334206 NOTES:NJ
is: SBO:0000185
product: MODEL1310110045#
fast: false

metaR GSNt
type: Reaction
kinetic law: MODEL1310110045#
fast: false
notes: GENE_ASSOCIATION: (3177.1) or (2030.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10722669,PMID:12838422 NOTES:IT
is: SBO:0000185
reactant: MODEL1310110045#
product: MODEL1310110045#
is described by: ECO:0000269
name: guanosine facilated transport in cytosol
reversible: true
modifier: MODEL1310110045#

metaM Rtotal2 e
initial amount: NaN
boundary condition: false
is: CHEBI:3554
type: Species
is: C00255
is: SBO:0000247
name: R total 2 position
constant: false
notes: FORMULA: CO2FULLR2 CHARGE: -1
is: HMDB00244
has only substance units: false
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110045#_8996a382_8773_4e20_8aa3_fb90d921c163
initial amount: NaN
has only substance units: false
is: SBO:0000252
type: Species
is: Q8N9L9
boundary condition: true
constant: false
is encoded by: hsa:122970
initial concentration: NaN
name: ACOT4

metaM sarcs c
is: CHEBI:3513
is: SBO:0000247
notes: FORMULA: C3H7NO2 CHARGE: 0
has only substance units: false
type: Species
initial concentration: 1.0
is: C00213
initial amount: NaN
constant: false
name: Sarcosine
is: HMDB00271
boundary condition: false

metaR ENGASE3ly
notes: GENE_ASSOCIATION: SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.96 Confidence Level: 0 AUTHORS: NOTES:NCD
is: SBO:0000176
kinetic law: MODEL1310110045#
fast: false
product: MODEL1310110045#
reversible: false
reactant: MODEL1310110045#
is described by: ECO:0000000
type: Reaction
name: endo-beta-N-acetylglucosaminidase, lysosomal

http://identifiers.org/biomodels.db/MODEL1310110045#_40dcbaf9_4b32_4962_b27f_b305094361d4
has only substance units: false
is encoded by: hsa:2639
name: GCDH
is: SBO:0000252
initial concentration: NaN
constant: false
boundary condition: true
initial amount: NaN
type: Species
is: Q92947

http://identifiers.org/biomodels.db/MODEL1310110045#_d3e7f317_fba2_4e8e_a00f_351ad687130d
type: Species
initial amount: NaN
name: COX6B1
constant: false
is: SBO:0000252
is: P14854
is encoded by: hsa:1340
has only substance units: false
initial concentration: NaN
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110045#_3fc2d71c_88ed_4af9_9bb5_1b6658e6018d
initial amount: NaN
is: SBO:0000252
name: PGM3
has only substance units: false
is: B4DX94
constant: false
type: Species
boundary condition: true
is encoded by: hsa:5238
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110045#_99cc7d3d_0703_4167_a837_c3fd2cec53f1
constant: false
boundary condition: true
initial concentration: NaN
has only substance units: false
name: NDUFA1
initial amount: NaN
type: Species
is: SBO:0000252
is: Q6IBB5
is encoded by: hsa:4694

metaM mal L c
constant: false
boundary condition: false
initial amount: NaN
name: (S)-malate(2-)
type: Species
is: CHEBI:15589
notes: FORMULA: C4H4O5 CHARGE: -2 INCHI: InChI=1S/C4H6O5/c5-2(4(8)9)1-3(6)7/h2,5H,1H2,(H,6,7)(H,8,9)/p-2/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00146
is: SBO:0000247
initial concentration: 1.0
has only substance units: false
is: HMDB00156

metaR EX gln L LPAREN e RPAREN
kinetic law: MODEL1310110045#
reactant: MODEL1310110045#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for L-glutamine
type: Reaction

metaR GALASE14ly
is: SBO:0000176
name: beta-galactosidase, lysosomal
reversible: false
kinetic law: MODEL1310110045#
type: Reaction
is version of: http://identifiers.org/ec-code/3.2.1.18
fast: false
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) or (5476.1) and (2720.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.23 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD
product: MODEL1310110045#
reactant: MODEL1310110045#
is version of: http://identifiers.org/ec-code/3.1.6.4
is version of: http://identifiers.org/ec-code/3.2.1.23
is version of: http://identifiers.org/ec-code/3.4.16.5
modifier: MODEL1310110045#

metaM HC02204 c
has only substance units: false
name: prostaglandin-b1
type: Species
initial amount: NaN
constant: false
notes: FORMULA: C20H31O4 CHARGE: -1 INCHI: InChI=1S/C20H32O4/c1-2-3-6-9-17(21)14-12-16-13-15-19(22)18(16)10-7-4-5-8-11-20(23)24/h12,14,17,21H,2-11,13,15H2,1H3,(H,23,24)/b14-12+/t17-/m0/s1 EHMN_ABBREVIATION: C00959
initial concentration: 1.0
is: SBO:0000247
boundary condition: false
is: CHEBI:27624

metaR EX dgchol LPAREN e RPAREN
kinetic law: MODEL1310110045#
reactant: MODEL1310110045#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Chenodeoxyglycocholate exchange
type: Reaction

metaM udpacgal l
initial concentration: 1.0
initial amount: NaN
constant: false
type: Species
is: CHEBI:57847
name: UDP-N-acetyl-D-galactosamine(2-)
is: SBO:0000247
is: HMDB00304
boundary condition: false
notes: FORMULA: C17H25N3O17P2 CHARGE: -2 INCHI: InChI=1S/C17H27N3O17P2/c1-6(22)18-10-13(26)11(24)7(4-21)35-16(10)36-39(31,32)37-38(29,30)33-5-8-12(25)14(27)15(34-8)20-3-2-9(23)19-17(20)28/h2-3,7-8,10-16,21,24-27H,4-5H2,1H3,(H,18,22)(H,29,30)(H,31,32)(H,19,23,28)/p-2/t7-,8-,10-,11+,12-,13-,14-,15-,16?/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00190 EHMN_ABBREVIATION: C00203
has only substance units: false

metaM 3octdectecoa m
is: HMDB06294
boundary condition: false
type: Species
constant: false
is: SBO:0000247
initial concentration: 1.0
name: 3,6,9,12-octadecatetraenoylcoa
initial amount: NaN
has only substance units: false
notes: FORMULA: C39H58N7O17P3S CHARGE: -4

http://identifiers.org/biomodels.db/MODEL1310110045#_41730603_6c69_4242_bcfd_0fc5365ca7ab
type: Species
has only substance units: false
is: SBO:0000252
is encoded by: hsa:91703
constant: false
initial concentration: NaN
name: ACY3
boundary condition: true
initial amount: NaN
is: Q96HD9

metaR S23T4g
kinetic law: MODEL1310110045#
type: Reaction
reactant: MODEL1310110045#
reversible: false
is version of: http://identifiers.org/ec-code/2.4.99.4
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (6484.1) or (6482.1) or (6483.1) or (6482.2) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.99.4 Confidence Level: 4 AUTHORS: PMID:10504389,PMID:7901202,PMID:8027041,PMID:8288606,PMID:8920913 NOTES:NCD
modifier: MODEL1310110045#
name: beta-galactoside alpha-2,3-sialyltransferase
fast: false
is: SBO:0000176
product: MODEL1310110045#

metaM CE2431 m
initial amount: NaN
boundary condition: false
name: cis-deca-4-enoyl-CoA
has only substance units: false
initial concentration: 1.0
is: SBO:0000247
notes: FORMULA: C31H48N7O17P3S CHARGE: -4 INCHI: InChI=1/C31H52N7O17P3S/c1-4-5-6-7-8-9-10-11-22(40)59-15-14-33-21(39)12-13-34-29(43)26(42)31(2,3)17-52-58(49,50)55-57(47,48)51-16-20-25(54-56(44,45)46)24(41)30(53-20)38-19-37-23-27(32)35-18-36-28(23)38/h8-9,18-20,24-26,30,41-42H,4-7,10-17H2,1-3H3,(H,33,39)(H,34,43)(H,47,48)(H,49,50)(H2,32,35,36)(H2,44,45,46)/p-4/b9-8-/t20-,24+,25+,26u,30-/m0/s1 EHMN_ABBREVIATION: CE2431
is: CHEBI:57795
constant: false
type: Species

metaR EX 11 cis retfa LPAREN e RPAREN
kinetic law: MODEL1310110045#
reactant: MODEL1310110045#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: fatty acid 11-cis-retinol exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110045#_800d6aa0_f129_4d79_b6bb_55de51017d2c
has only substance units: false
initial amount: NaN
is: SBO:0000252
constant: false
boundary condition: true
name: MTMR6
is encoded by: hsa:9107
is: Q9Y217
type: Species
initial concentration: NaN

metaR r2364
reversible: true
is described by: ECO:0000000
type: Reaction
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
fast: false
product: MODEL1310110045#
name: Organic anion transporter 5 Utilized transport
kinetic law: MODEL1310110045#
reactant: MODEL1310110045#

http://identifiers.org/biomodels.db/MODEL1310110045#_c16d6939_458e_41a2_a871_597a5ddf5b48
type: Species
initial amount: NaN
constant: false
is encoded by: hsa:229
boundary condition: true
has only substance units: false
name: ALDOB
is: P05062
is: SBO:0000252
initial concentration: NaN

metaM h2o c
notes: FORMULA: H2O CHARGE: 0
is: C00001
is: CHEBI:3303
is: HMDB02111
name: H2O
initial concentration: 1.0
boundary condition: false
is: SBO:0000247
type: Species
has only substance units: false
constant: false
initial amount: NaN

metaR ACACt2m
kinetic law: MODEL1310110045#
modifier: MODEL1310110045#
is described by: ECO:0000269
name: Acetoacetate mitochondrial transport via H+ symport
reactant: MODEL1310110045#
is: SBO:0000185
fast: false
product: MODEL1310110045#
notes: GENE_ASSOCIATION: (6566.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:28726,PMID:627555 NOTES:IT, TDV changed name from "tm2" to "t2m" - NCD
type: Reaction
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110045#_864ce985_91a0_4cd9_aae8_834db3ec3426
is: SBO:0000252
name: PIK3R2
initial concentration: NaN
type: Species
is encoded by: hsa:5296
has only substance units: false
initial amount: NaN
boundary condition: true
constant: false
is: O00459

metaM CE2705 c
is: SBO:0000247
name: quinonoid dihydrobiopterin
initial concentration: 1.0
has only substance units: false
constant: false
initial amount: NaN
is: CHEBI:36781
notes: FORMULA: C9H13N5O3 CHARGE: 0 INCHI: InChI=1/C9H13N5O3/c1-3(15)6(16)4-2-11-7-5(12-4)8(17)14-9(10)13-7/h3-4,6,15-16H,2H2,1H3,(H3,10,11,13,14,17)/p+1/t3-,4?,6+/m0/s1 EHMN_ABBREVIATION: CE2705
type: Species
boundary condition: false

metaR r0672
fast: false
reactant: MODEL1310110045#
name: Cholest-5-ene-3beta,7alpha-diol:NAD+ 3-oxidoreductase Bile acid biosynthesis EC:1.1.1.181
product: MODEL1310110045#
type: Reaction
kinetic law: MODEL1310110045#
reversible: true
notes: GENE_ASSOCIATION: (570.1) SUBSYSTEM: Bile acid synthesis EC Number: 1.1.1.181 Confidence Level: 0 AUTHORS: PMID:12679481 NOTES:
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.3.1.65
modifier: MODEL1310110045#
is described by: ECO:0000000

metaR NOt
type: Reaction
name: NO transport (diffusion)
is: SBO:0000185
reversible: true
is described by: ECO:0000000
product: MODEL1310110045#
kinetic law: MODEL1310110045#
fast: false
reactant: MODEL1310110045#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 1 AUTHORS: NOTES:IT (06-16-04)

metaM thm c
initial amount: NaN
is: SBO:0000247
notes: FORMULA: C12H17N4OS CHARGE: 1
type: Species
constant: false
initial concentration: 1.0
has only substance units: false
boundary condition: false
is: HMDB00235
is: CHEBI:0
is: C00378
name: Thiamin

metaR GDPtg
reactant: MODEL1310110045#
fast: false
is described by: ECO:0000000
reversible: true
kinetic law: MODEL1310110045#
is: SBO:0000185
product: MODEL1310110045#
type: Reaction
name: GDP intracellular transport
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 1 AUTHORS: NOTES:unknown mechanism for transport - likely translocated, unknown transporter/mechanism though NJ

http://identifiers.org/biomodels.db/MODEL1310110045#_4214658a_7783_49ba_92fa_a749a76ba943
name: CHKB
is: SBO:0000252
is: Q9Y259
boundary condition: true
type: Species
initial amount: NaN
is encoded by: hsa:1120
constant: false
initial concentration: NaN
has only substance units: false

metaM HC02204 e
is: CHEBI:27624
name: prostaglandin-b1
is: SBO:0000247
initial amount: NaN
notes: FORMULA: C20H31O4 CHARGE: -1 INCHI: InChI=1S/C20H32O4/c1-2-3-6-9-17(21)14-12-16-13-15-19(22)18(16)10-7-4-5-8-11-20(23)24/h12,14,17,21H,2-11,13,15H2,1H3,(H,23,24)/b14-12+/t17-/m0/s1 EHMN_ABBREVIATION: C00959
initial concentration: 1.0
has only substance units: false
type: Species
boundary condition: false
constant: false

metaR r2365
product: MODEL1310110045#
name: Organic anion transporter 5 Utilized transport
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
is described by: ECO:0000000
reactant: MODEL1310110045#
type: Reaction
kinetic law: MODEL1310110045#
fast: false
is: SBO:0000185
reversible: true

metaR r0527
reversible: true
type: Reaction
kinetic law: MODEL1310110045#
fast: false
is: SBO:0000176
product: MODEL1310110045#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: NAD metabolism EC Number: 3.5.1.42 Confidence Level: 0 AUTHORS: PMID:7021549 NOTES:
name: Nicotinamide-D-ribonucleotide amidohydrolase Nicotinate and nicotinamide metabolism EC:3.5.1.42
reactant: MODEL1310110045#

http://identifiers.org/biomodels.db/MODEL1310110045#_50b48c2b_4289_4aaa_bd39_e237d26a5b6c
type: Species
is: SBO:0000297
initial concentration: NaN
constant: false
boundary condition: true
initial amount: NaN
has part: P27986
name: PIK3CA:PIK3R1
is encoded by: hsa:5295
has only substance units: false

metaR PDE1
name: 3',5'-cyclic-nucleotide phosphodiesterase
notes: GENE_ASSOCIATION: (5139.1) or (5142.1) or (5151.3) or (5153.1) or (5150.2) or (5143.1) or (5150.1) or (5137.1) or (5144.1) or (5136.2) or (5140.2) or (5151.2) or (10846.1) or (5151.5) or (5140.1) or (5141.1) or (5138.1) or (5136.1) or (5151.4) or (5151.1) or (27115.1) or (50940.1) or (8622.1) SUBSYSTEM: Nucleotide interconversion EC Number: 3.1.4.17 Confidence Level: 4 AUTHORS: PMID:10725373,PMID:10872825,PMID:10906126,PMID:10952971,PMID:11050148,PMID:11114167,PMID:12038792,PMID:12135876,PMID:12154085,PMID:12388353,PMID:12681444,PMID:12764607,PMID:14604994,PMID:15147193,PMID:15272012,PMID:15480303,PMID:8884271,PMID:9210593,PMID:9419816 NOTES:NCD
reactant: MODEL1310110045#
product: MODEL1310110045#
is: SBO:0000176
reversible: false
modifier: MODEL1310110045#
fast: false
type: Reaction
is version of: http://identifiers.org/ec-code/3.1.4.35
kinetic law: MODEL1310110045#
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/3.1.4.17

http://identifiers.org/biomodels.db/MODEL1310110045#_d3c6e963_cef3_4c07_834a_aa08cbefc696
boundary condition: true
has only substance units: false
constant: false
name: MTHFD2L
initial concentration: NaN
is: SBO:0000252
initial amount: NaN
is: Q9H903
is encoded by: hsa:441024
type: Species

http://identifiers.org/biomodels.db/MODEL1310110045#_f99662a0_60fe_4fce_9a0d_53c51aec3323
constant: false
has only substance units: false
is: Q9BYC5
initial amount: NaN
type: Species
initial concentration: NaN
name: FUT8
is: SBO:0000252
is encoded by: hsa:2530
boundary condition: true

metaR DHORTS
kinetic law: MODEL1310110045#
fast: false
reactant: MODEL1310110045#
name: dihydroorotase
reversible: true
is version of: http://identifiers.org/ec-code/2.1.3.2
is described by: ECO:0000269
type: Reaction
modifier: MODEL1310110045#
is: SBO:0000176
product: MODEL1310110045#
notes: GENE_ASSOCIATION: (790.1) SUBSYSTEM: Pyrimidine synthesis EC Number: 3.5.2.3 Confidence Level: 4 AUTHORS: PMID:2565865,PMID:8619816 NOTES:

metaR EX cgly LPAREN e RPAREN
kinetic law: MODEL1310110045#
reactant: MODEL1310110045#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Cys-Gly exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110045#_99e89e93_7c3c_49c2_9c2a_66d48046e0df
is: SBO:0000252
has only substance units: false
constant: false
type: Species
is encoded by: hsa:5019
initial amount: NaN
is: P55809
name: OXCT1
boundary condition: true
initial concentration: NaN

metaR r2366
is described by: ECO:0000000
type: Reaction
is: SBO:0000185
product: MODEL1310110045#
name: Organic anion transporter 5 Utilized transport
reactant: MODEL1310110045#
reversible: true
kinetic law: MODEL1310110045#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110045#_a2cdcd70_0175_4d8f_bb36_3634221ec1f1
has only substance units: false
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:9061
type: Species
boundary condition: true
name: PAPSS1
constant: false
is: O43252
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110045#_c0ce119a_fb38_447b_af15_060a30d9faf4
type: Species
has only substance units: false
is: P55084
boundary condition: true
name: HADHB
constant: false
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:3032
is: SBO:0000252

metaM Lkynr c
type: Species
has only substance units: false
notes: FORMULA: C10H12N2O3 CHARGE: 0 INCHI: InChI=1S/C10H12N2O3/c11-7-4-2-1-3-6(7)9(13)5-8(12)10(14)15/h1-4,8H,5,11-12H2,(H,14,15)/t8-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00278 EHMN_ABBREVIATION: C00328
boundary condition: false
initial concentration: 1.0
initial amount: NaN
is: HMDB00684
name: L-kynurenine
is: CHEBI:16946
is: SBO:0000247
constant: false

http://identifiers.org/biomodels.db/MODEL1310110045#_9ab97db0_d159_4ad7_8f03_1f52d2f21d95
boundary condition: true
constant: false
initial amount: NaN
name: EARS2
has only substance units: false
initial concentration: NaN
is encoded by: hsa:124454
type: Species
is: SBO:0000252
is: Q5JPH6

http://identifiers.org/biomodels.db/MODEL1310110045#_ec00e5c7_1707_4ede_8e0a_5f9f683cfd65
name: GMPR
is: SBO:0000252
boundary condition: true
type: Species
initial amount: NaN
has only substance units: false
is: P36959
is encoded by: hsa:2766
initial concentration: NaN
constant: false

metaR r2367
is described by: ECO:0000000
product: MODEL1310110045#
reactant: MODEL1310110045#
type: Reaction
name: Organic anion transporter 5 Utilized transport
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
fast: false
kinetic law: MODEL1310110045#
is: SBO:0000185
reversible: true

metaM 3pg m
name: (2R)-2-hydroxy-3-(phosphonatooxy)propanoate
has only substance units: false
is: CHEBI:58272
initial amount: NaN
is: HMDB00807
boundary condition: false
initial concentration: 1.0
notes: FORMULA: C3H4O7P CHARGE: -3 INCHI: InChI=1S/C3H7O7P/c4-2(3(5)6)1-10-11(7,8)9/h2,4H,1H2,(H,5,6)(H2,7,8,9)/p-3/t2-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00186 EHMN_ABBREVIATION: C00197
type: Species
constant: false
is: SBO:0000247

metaR EX bilirub LPAREN e RPAREN
kinetic law: MODEL1310110045#
reactant: MODEL1310110045#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Bilirubin exchange
type: Reaction

metaM btcoa c
is: SBO:0000247
notes: FORMULA: C25H38N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00134 EHMN_ABBREVIATION: C00136
type: Species
initial concentration: 1.0
boundary condition: false
has only substance units: false
name: Butanoyl-CoA
constant: false
is: C00136
is: HMDB01088
is: CHEBI:57371
initial amount: NaN

metaR O2tm
is described by: ECO:0000000
type: Reaction
is: SBO:0000185
kinetic law: MODEL1310110045#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 1 AUTHORS: PMID:2551143 NOTES:IF
reactant: MODEL1310110045#
product: MODEL1310110045#
name: O2 transport (diffusion)
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110045#_11bdb83c_1d74_4e63_b979_f3b9fd639851
is: H7C5B8
boundary condition: true
initial amount: NaN
type: Species
initial concentration: NaN
constant: false
has only substance units: false
name: NDUFB2
is: SBO:0000252
is encoded by: hsa:4708

metaR EX spmd LPAREN e RPAREN
kinetic law: MODEL1310110045#
reactant: MODEL1310110045#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of spermidine(3+)
type: Reaction

metaM man6p c
has only substance units: false
name: D-Mannose 6-phosphate
is: HMDB01078
boundary condition: false
constant: false
notes: FORMULA: C6H11O9P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00246 EHMN_ABBREVIATION: C00275
initial concentration: 1.0
initial amount: NaN
is: SBO:0000247
is: CHEBI:17369
type: Species

http://identifiers.org/biomodels.db/MODEL1310110045#_2d238a43_d212_40d4_89fe_bb43812f0acd
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:1892
type: Species
has only substance units: false
is: P30084
initial concentration: NaN
constant: false
boundary condition: true
name: ECHS1

http://identifiers.org/biomodels.db/MODEL1310110045#_42a96b6c_ea21_4f9a_8136_fd454c90df11
initial amount: NaN
name: _AU149534_1_m
has only substance units: false
boundary condition: true
is: SBO:0000252
initial concentration: NaN
constant: false
is encoded by: hsa:AU149534
type: Species

metaR OCDCEAtr
name: fatty acid transport via diffusion
reactant: MODEL1310110045#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11788354,PMID:12864740 NOTES:NJ
is described by: ECO:0000000
reversible: true
fast: false
product: MODEL1310110045#
kinetic law: MODEL1310110045#
is: SBO:0000185
type: Reaction

metaR UMPK3
fast: false
name: UMP kinase (UTP)
is version of: http://identifiers.org/ec-code/2.7.4.14
reactant: MODEL1310110045#
product: MODEL1310110045#
modifier: MODEL1310110045#
is described by: ECO:0000269
reversible: true
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
type: Reaction
kinetic law: MODEL1310110045#
is: SBO:0000176

metaR r2360
fast: false
is described by: ECO:0000000
type: Reaction
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
kinetic law: MODEL1310110045#
product: MODEL1310110045#
name: Organic anion transporter 5 Utilized transport
is: SBO:0000185
reactant: MODEL1310110045#

metaM dopasf e
boundary condition: false
initial amount: NaN
is: SBO:0000247
name: dopamine 3-O-sulfate
is: HMDB06275
initial concentration: 1.0
is: CHEBI:37946
notes: FORMULA: C8H11NO5S CHARGE: 0 INCHI: InChI=1S/C8H11NO5S/c9-4-3-6-1-2-7(10)8(5-6)14-15(11,12)13/h1-2,5,10H,3-4,9H2,(H,11,12,13) EHMN_ABBREVIATION: C13690
type: Species
constant: false
has only substance units: false

metaM sucsal m
boundary condition: false
is: CHEBI:57706
name: Succinic semialdehyde
has only substance units: false
type: Species
initial amount: NaN
initial concentration: 1.0
is: HMDB01259
constant: false
is: SBO:0000247
notes: FORMULA: C4H5O3 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00210 EHMN_ABBREVIATION: C00232

metaR r0522
modifier: MODEL1310110045#
name: S-Aminomethyldihydrolipoylprotein:(6S)-tetrahydrofolate aminomethyltransferase (ammonia-forming) One carbon pool by folate EC:2.1.2.10
type: Reaction
notes: GENE_ASSOCIATION: (6576.1) SUBSYSTEM: Folate metabolism EC Number: 2.1.2.10 Confidence Level: 0 AUTHORS: PMID:7916605 NOTES:
kinetic law: MODEL1310110045#
reactant: MODEL1310110045#
fast: false
is: SBO:0000176
reversible: false
is described by: ECO:0000000
product: MODEL1310110045#

http://identifiers.org/biomodels.db/MODEL1310110045#_680e8738_1c66_4103_a95f_c54b00a8042c
boundary condition: true
is encoded by: hsa:R51273
initial amount: NaN
type: Species
initial concentration: NaN
is: SBO:0000252
name: _R51273_1_c
has only substance units: false
constant: false

metaM sarcs m
boundary condition: false
is: SBO:0000247
notes: FORMULA: C3H7NO2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00197 EHMN_ABBREVIATION: C00213
initial amount: NaN
is: HMDB00271
initial concentration: 1.0
is: CHEBI:15611
is: C00213
name: Sarcosine
type: Species
has only substance units: false
constant: false

metaM 6a2ohxnt x
has only substance units: false
is: CHEBI:17534
initial concentration: 1.0
notes: FORMULA: C6H11NO3 CHARGE: 0 INCHI: InChI=1S/C6H11NO3/c7-4-2-1-3-5(8)6(9)10/h1-4,7H2,(H,9,10) EHMN_ABBREVIATION: C03239
initial amount: NaN
name: 6-amino-2-oxohexanoic acid
constant: false
type: Species
is: HMDB12151
boundary condition: false
is: SBO:0000247

metaM sphgn c
has only substance units: false
type: Species
is: HMDB00269
is: SBO:0000247
boundary condition: false
notes: FORMULA: C18H40NO2 CHARGE: 1 INCHI: InChI=1S/C18H39NO2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-18(21)17(19)16-20/h17-18,20-21H,2-16,19H2,1H3/p+1/t17-,18+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00556 EHMN_ABBREVIATION: C00836
is: CHEBI:57817
name: sphinganine(1+)
constant: false
initial amount: NaN
initial concentration: 1.0

metaM hista c
is: HMDB00870
initial concentration: 1.0
type: Species
initial amount: NaN
name: histamium
is: SBO:0000247
is: CHEBI:58432
has only substance units: false
boundary condition: false
notes: FORMULA: C5H10N3 CHARGE: 1 INCHI: InChI=1S/C5H9N3/c6-2-1-5-3-7-4-8-5/h3-4H,1-2,6H2,(H,7,8)/p+1 HEPATONET_1.0_ABBREVIATION: HC00323 EHMN_ABBREVIATION: C00388
constant: false

metaM udpacgal g
is: HMDB00304
name: UDP-N-acetyl-D-galactosamine(2-)
has only substance units: false
notes: FORMULA: C17H25N3O17P2 CHARGE: -2 INCHI: InChI=1S/C17H27N3O17P2/c1-6(22)18-10-13(26)11(24)7(4-21)35-16(10)36-39(31,32)37-38(29,30)33-5-8-12(25)14(27)15(34-8)20-3-2-9(23)19-17(20)28/h2-3,7-8,10-16,21,24-27H,4-5H2,1H3,(H,18,22)(H,29,30)(H,31,32)(H,19,23,28)/p-2/t7-,8-,10-,11+,12-,13-,14-,15-,16?/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00190 EHMN_ABBREVIATION: C00203
constant: false
initial concentration: 1.0
type: Species
boundary condition: false
is: SBO:0000247
is: CHEBI:57847
initial amount: NaN

metaR UMPK2
modifier: MODEL1310110045#
reversible: true
fast: false
is version of: http://identifiers.org/ec-code/2.7.4.14
type: Reaction
product: MODEL1310110045#
name: UMP kinase (CTP)
reactant: MODEL1310110045#
is: SBO:0000176
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
kinetic law: MODEL1310110045#
is described by: ECO:0000269

metaR r0523
fast: false
kinetic law: MODEL1310110045#
notes: GENE_ASSOCIATION: (BE966236.1) or (6240.1) or (6241.1) or (50484.1) SUBSYSTEM: Folate metabolism EC Number: 6.3.3.2 Confidence Level: 0 AUTHORS: PMID:12207015,PMID:12764149,PMID:8522195 NOTES:
type: Reaction
modifier: MODEL1310110045#
reversible: false
is version of: http://identifiers.org/ec-code/1.17.4.1
is: SBO:0000176
product: MODEL1310110045#
is described by: ECO:0000000
name: 5-Formyltetrahydrofolate cyclo-ligase (ADP-forming) One carbon pool by folate EC:6.3.3.2
reactant: MODEL1310110045#

metaR AG13T5g
notes: GENE_ASSOCIATION: (79369.1) or (374907.1) or (11041.1) or (146712.1) or (374907.2) or (93010.1) or (10331.1) or (10678.1) or (10678.2) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.149 Confidence Level: 4 AUTHORS: PMID:10747980,PMID:11042166,PMID:12061784,PMID:12512857,PMID:15560372,PMID:15620693,PMID:9405606 NOTES:NCD
fast: false
type: Reaction
kinetic law: MODEL1310110045#
modifier: MODEL1310110045#
is: SBO:0000176
is described by: ECO:0000000
name: N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase, Golgi apparatus
reactant: MODEL1310110045#
product: MODEL1310110045#
reversible: false
is version of: http://identifiers.org/ec-code/2.4.1.149

http://identifiers.org/biomodels.db/MODEL1310110045#_37307643_c7e2_4bf6_87d7_ae27c5749eec
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:U37519
type: Species
boundary condition: true
name: _U37519_1_e
has only substance units: false
constant: false
is: SBO:0000252

metaR r2361
product: MODEL1310110045#
name: Organic anion transporter 5 Utilized transport
reversible: true
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
fast: false
is described by: ECO:0000000
kinetic law: MODEL1310110045#
reactant: MODEL1310110045#
type: Reaction

metaM fgam c
constant: false
name: N2-Formyl-N1-(5-phospho-D-ribosyl)glycinamide
is: C04376
is: CHEBI:58426
boundary condition: false
initial concentration: 1.0
notes: FORMULA: C8H13N2O9P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC01281 EHMN_ABBREVIATION: C04376
initial amount: NaN
type: Species
is: HMDB01308
has only substance units: false
is: SBO:0000247

metaR DCMPDA
reversible: true
notes: GENE_ASSOCIATION: (1635.1) SUBSYSTEM: Pyrimidine catabolism EC Number: 3.5.4.12 Confidence Level: 2 AUTHORS: PMID:7642519,PMID:7685356 NOTES:NCD
is version of: http://identifiers.org/ec-code/3.5.4.12
is described by: ECO:0000254
is: SBO:0000176
name: dCMP deaminase
reactant: MODEL1310110045#
fast: false
product: MODEL1310110045#
modifier: MODEL1310110045#
kinetic law: MODEL1310110045#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110045#_09d32d46_d502_4555_949e_9362f8c9c7e8
initial amount: NaN
is: SBO:0000297
boundary condition: true
constant: false
name: NME1:NME2
is encoded by: hsa:4830
has only substance units: false
initial concentration: NaN
type: Species

http://identifiers.org/biomodels.db/MODEL1310110045#_e741746e_8800_48ed_b52e_2a85c92ca851
boundary condition: true
initial amount: NaN
constant: false
is encoded by: hsa:26503
type: Species
is: Q9NRA2
initial concentration: NaN
name: SLC17A5
is: SBO:0000252
has only substance units: false

metaR UMPK5
is version of: http://identifiers.org/ec-code/2.7.4.14
product: MODEL1310110045#
name: UMP kinase (dATP)
reversible: true
reactant: MODEL1310110045#
modifier: MODEL1310110045#
fast: false
type: Reaction
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
is: SBO:0000176
is described by: ECO:0000269
kinetic law: MODEL1310110045#

http://identifiers.org/biomodels.db/MODEL1310110045#_5c7432dc_42fd_4e15_9ceb_7139aaf34ca5
initial concentration: NaN
has only substance units: false
name: SLC9A3
constant: false
is encoded by: hsa:6550
is: P48764
boundary condition: true
is: SBO:0000252
type: Species
initial amount: NaN

metaM dopasf c
name: dopamine 3-O-sulfate
constant: false
is: HMDB06275
initial amount: NaN
is: SBO:0000247
initial concentration: 1.0
notes: FORMULA: C8H11NO5S CHARGE: 0 INCHI: InChI=1S/C8H11NO5S/c9-4-3-6-1-2-7(10)8(5-6)14-15(11,12)13/h1-2,5,10H,3-4,9H2,(H,11,12,13) EHMN_ABBREVIATION: C13690
has only substance units: false
is: CHEBI:37946
type: Species
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110045#_c6daff14_2618_4196_a731_bd0c2100a638
is: P52790
has only substance units: false
initial amount: NaN
name: HK3
is encoded by: hsa:3101
is: SBO:0000252
initial concentration: NaN
constant: false
boundary condition: true
type: Species

metaM etfrd m
is: HMDB01356
initial concentration: 1.0
has only substance units: false
is: CHEBI:57312
type: Species
initial amount: NaN
is: SBO:0000247
boundary condition: false
notes: FORMULA: RH2 CHARGE: 0
name: Electron transfer flavoprotein reduced
constant: false

metaR S2L2FN2M2MASNt
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD
name: s2l2fn2m2masn transport, Golgi to extracellular
product: MODEL1310110045#
type: Reaction
fast: false
reversible: false
reactant: MODEL1310110045#
is: SBO:0000185
kinetic law: MODEL1310110045#

metaR r2362
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
is described by: ECO:0000000
type: Reaction
product: MODEL1310110045#
is: SBO:0000185
name: Organic anion transporter 5 Utilized transport
reactant: MODEL1310110045#
fast: false
kinetic law: MODEL1310110045#
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110045#_f44b2051_f0da_4669_b925_951b1a9caef5
constant: false
name: SDHD
initial amount: NaN
initial concentration: NaN
type: Species
is: O14521
is: SBO:0000252
boundary condition: true
is encoded by: hsa:6392
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110045#_581538f4_8fb4_4934_bd01_45bb1e0132c1
initial concentration: NaN
has only substance units: false
is: Q10469
is encoded by: hsa:4247
initial amount: NaN
type: Species
is: SBO:0000252
constant: false
boundary condition: true
name: MGAT2

metaR EX inost LPAREN e RPAREN
kinetic law: MODEL1310110045#
reactant: MODEL1310110045#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: myo-Inositol exchange
type: Reaction

metaM hista e
type: Species
initial concentration: 1.0
initial amount: NaN
is: SBO:0000247
name: histamium
is: CHEBI:58432
boundary condition: false
constant: false
has only substance units: false
is: HMDB00870
notes: FORMULA: C5H10N3 CHARGE: 1 INCHI: InChI=1S/C5H9N3/c6-2-1-5-3-7-4-8-5/h3-4H,1-2,6H2,(H,7,8)/p+1 HEPATONET_1.0_ABBREVIATION: HC00323 EHMN_ABBREVIATION: C00388

metaR MTHFCm
reactant: MODEL1310110045#
is described by: ECO:0000269
fast: false
is version of: http://identifiers.org/ec-code/3.5.4.9
kinetic law: MODEL1310110045#
reversible: true
type: Reaction
is version of: http://identifiers.org/ec-code/6.3.4.3
notes: GENE_ASSOCIATION: (25902.1) or (10797.1) SUBSYSTEM: Folate metabolism EC Number: 3.5.4.9 Confidence Level: 4 AUTHORS: PMID:12937168 NOTES:NCD
product: MODEL1310110045#
modifier: MODEL1310110045#
name: methenyltetrahydrifikate cyclohydrolase, mitochondrial
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110045#_6205efe0_108f_488d_a3fa_14c8b594a08c
boundary condition: true
name: _AL525798_1_c
constant: false
has only substance units: false
initial amount: NaN
is encoded by: hsa:AL525798
type: Species
initial concentration: NaN
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110045#_07373b82_6697_439b_8719_9527d7a81f77
initial amount: NaN
boundary condition: true
is: SBO:0000252
name: NME2
is encoded by: hsa:4831
type: Species
has only substance units: false
constant: false
is: P22392
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110045#_8863c70c_f426_4cf1_a9cf_d7cd2308dbf9
constant: false
initial concentration: NaN
type: Species
is encoded by: hsa:171425
name: CLYBL
boundary condition: true
initial amount: NaN
has only substance units: false
is: SBO:0000252

metaM icit x
initial concentration: 1.0
is: CHEBI:16087
type: Species
notes: FORMULA: C6H5O7 CHARGE: -3 INCHI: InChI=1S/C6H8O7/c7-3(8)1-2(5(10)11)4(9)6(12)13/h2,4,9H,1H2,(H,7,8)(H,10,11)(H,12,13)/p-3 HEPATONET_1.0_ABBREVIATION: HC00266 EHMN_ABBREVIATION: C00311
initial amount: NaN
is: SBO:0000247
is: HMDB00193
name: isocitrate(3-)
has only substance units: false
boundary condition: false
constant: false

http://identifiers.org/biomodels.db/MODEL1310110045#_ac731be8_c6d7_4567_9552_3bc62f5e98f0
constant: false
is encoded by: hsa:8372
type: Species
is: SBO:0000252
is: O43820
initial concentration: NaN
name: HYAL3
initial amount: NaN
has only substance units: false
boundary condition: true

metaR EX so4 LPAREN e RPAREN
kinetic law: MODEL1310110045#
reactant: MODEL1310110045#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Sulfate exchange
type: Reaction

metaR UMPK4
reversible: true
fast: false
modifier: MODEL1310110045#
name: UMP kinase (GTP)
type: Reaction
reactant: MODEL1310110045#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.7.4.14
product: MODEL1310110045#
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
kinetic law: MODEL1310110045#

metaR RE1254C
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Lysine metabolism EC Number: 1.14.17.1 Confidence Level: 0 AUTHORS: PMID:3443096,PMID:7759508,PMID:9763470 NOTES:
is: SBO:0000176
reversible: true
kinetic law: MODEL1310110045#
product: MODEL1310110045#
type: Reaction
name: RE1254
is described by: ECO:0000000
reactant: MODEL1310110045#

http://identifiers.org/biomodels.db/MODEL1310110045#_dd7e0ae1_0f45_4783_a79b_2cc21f77fe22
type: Species
constant: false
initial amount: NaN
is: SBO:0000252
has only substance units: false
is: O14975
boundary condition: true
name: SLC27A2
initial concentration: NaN
is encoded by: hsa:11001

metaR r2363
is: SBO:0000185
is described by: ECO:0000000
product: MODEL1310110045#
reactant: MODEL1310110045#
type: Reaction
fast: false
reversible: true
name: Organic anion transporter 5 Utilized transport
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
kinetic law: MODEL1310110045#

http://identifiers.org/biomodels.db/MODEL1310110045#_b0658f7e_86c3_4700_9cb0_2710217bdbb6
boundary condition: true
is: B7Z4Y6
is encoded by: hsa:249
initial concentration: NaN
is: SBO:0000252
type: Species
has only substance units: false
constant: false
initial amount: NaN
name: ALPL

metaR UDPGLCAter
notes: GENE_ASSOCIATION: (23169.1) SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 4 AUTHORS: PMID:11322953 NOTES:NCD
type: Reaction
name: UDPGlcA endoplasmic reticulum transport via UMP antiport
product: MODEL1310110045#
modifier: MODEL1310110045#
is: SBO:0000185
reversible: true
is described by: ECO:0000269
kinetic law: MODEL1310110045#
reactant: MODEL1310110045#
fast: false

metaM 3pg c
is: CHEBI:58272
boundary condition: false
is: SBO:0000247
is: http://identifiers.org/pubchem.compound/3497
type: Species
has only substance units: false
initial concentration: 1.0
initial amount: NaN
name: 3-Phospho-D-glycerate
constant: false
is: C00197
is: HMDB00807

http://identifiers.org/biomodels.db/MODEL1310110045#_1094c0de_4bb3_47d3_8663_b5b2bcc3211b
initial concentration: NaN
constant: false
boundary condition: true
is: Q9UIG8
has only substance units: false
is: SBO:0000252
type: Species
name: SLCO3A1
initial amount: NaN
is encoded by: hsa:28232

http://identifiers.org/biomodels.db/MODEL1310110045#_067b2b69_f992_4007_a2d5_cf733fd6f167
boundary condition: true
is: B4DUY1
type: Species
constant: false
name: STARD3
is: SBO:0000252
initial concentration: NaN
initial amount: NaN
has only substance units: false
is encoded by: hsa:10948

metaM fmn c
notes: FORMULA: C17H19N4O9P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00064 EHMN_ABBREVIATION: C00061
type: Species
has only substance units: false
name: FMN
is: C00061
boundary condition: false
is: SBO:0000247
initial concentration: 1.0
initial amount: NaN
is: CHEBI:58210
constant: false
is: HMDB01520

http://identifiers.org/biomodels.db/MODEL1310110045#_6cea6c9a_4bef_4d74_a8b8_92210266053d
is: SBO:0000252
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:8611
boundary condition: true
name: PPAP2A
constant: false
is: G3XA95
has only substance units: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110045#_0253aeea_5500_4210_8874_a5585e083871
initial amount: NaN
initial concentration: NaN
has only substance units: false
type: Species
is encoded by: hsa:5335
is: P19174
boundary condition: true
name: PLCG1
is: SBO:0000252
constant: false

metaM 12ppd S c
initial amount: NaN
boundary condition: false
name: (S)-propane-1,2-diol
is: SBO:0000247
notes: FORMULA: C3H8O2 CHARGE: 0 INCHI: InChI=1S/C3H8O2/c1-3(5)2-4/h3-5H,2H2,1H3/t3-/m0/s1
has only substance units: false
type: Species
constant: false
is: CHEBI:29002
initial concentration: 1.0
is: HMDB06213

http://identifiers.org/biomodels.db/MODEL1310110045#_0d2206f9_61d9_49e4_b9ac_b7a6031de74e
type: Species
boundary condition: true
name: ADH7
constant: false
is: P40394
initial amount: NaN
is encoded by: hsa:131
is: SBO:0000252
has only substance units: false
initial concentration: NaN

metaR OXAHCOtex
modifier: MODEL1310110045#
is described by: ECO:0000304
fast: false
type: Reaction
reversible: false
reactant: MODEL1310110045#
is: SBO:0000185
notes: GENE_ASSOCIATION: (1836.1) or (10861.1) or (10861.3) or (10861.2) or (1811.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:12759755 NOTES:SAB
product: MODEL1310110045#
name: oxalate transport via bicarbonate countertransport
kinetic law: MODEL1310110045#

http://identifiers.org/biomodels.db/MODEL1310110045#_4c0af7f5_41e4_4697_bb39_401eeecb2a12
has only substance units: false
type: Species
is: SBO:0000252
name: PRPS2
is encoded by: hsa:5634
boundary condition: true
is: P11908
initial amount: NaN
constant: false
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110045#_76ae5717_5c72_4473_b0b3_b7e1e2fd714f
name: CTH
constant: false
initial amount: NaN
type: Species
is encoded by: hsa:1491
has only substance units: false
boundary condition: true
is: P32929
initial concentration: NaN
is: SBO:0000252

metaR C14STRr
reactant: MODEL1310110045#
modifier: MODEL1310110045#
is: SBO:0000176
fast: false
is described by: ECO:0000134
product: MODEL1310110045#
reversible: false
type: Reaction
kinetic law: MODEL1310110045#
notes: GENE_ASSOCIATION: (7108.1) SUBSYSTEM: Cholesterol metabolism EC Number: 1.3.1.70 Confidence Level: 4 AUTHORS: PMID:16784888 NOTES:NCD ER version NJ
name: C-14 sterol reductase
is version of: http://identifiers.org/ec-code/1.3.1.70

metaM arachd r
name: arachidonate
notes: FORMULA: C20H31O2 CHARGE: -1 INCHI: InChI=1S/C20H32O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20(21)22/h6-7,9-10,12-13,15-16H,2-5,8,11,14,17-19H2,1H3,(H,21,22)/p-1/b7-6-,10-9-,13-12-,16-15- HEPATONET_1.0_ABBREVIATION: HC00202 EHMN_ABBREVIATION: C00219
boundary condition: false
is: CHEBI:32395
constant: false
type: Species
initial amount: NaN
is: HMDB01043
initial concentration: 1.0
has only substance units: false
is: SBO:0000247

metaR TXA2te
reactant: MODEL1310110045#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:unknown mechanism for transport - known to be secreted from cells - unknown mechanism or pathway, TXA2tc -> TXA2te to get to EC space NJ
type: Reaction
fast: false
product: MODEL1310110045#
reversible: true
name: thromboxane A2 transport
is: SBO:0000185
kinetic law: MODEL1310110045#
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110045#_c73b9385_7905_475f_9e01_34b7b976df9b
name: PPA2
initial amount: NaN
constant: false
is: SBO:0000252
is encoded by: hsa:27068
has only substance units: false
initial concentration: NaN
boundary condition: true
type: Species

metaR GALASE11ly
is version of: http://identifiers.org/ec-code/3.4.16.5
fast: false
name: beta-galactosidase, lysosomal
product: MODEL1310110045#
reactant: MODEL1310110045#
is version of: http://identifiers.org/ec-code/3.2.1.23
modifier: MODEL1310110045#
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) or (5476.1) and (2720.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.23 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD
kinetic law: MODEL1310110045#
type: Reaction
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.2.1.18
reversible: false
is version of: http://identifiers.org/ec-code/3.1.6.4
is described by: ECO:0000000

metaM udpacgal c
is: CHEBI:57847
is: SBO:0000247
type: Species
boundary condition: false
constant: false
initial amount: NaN
initial concentration: 1.0
is: HMDB00304
notes: FORMULA: C17H25N3O17P2 CHARGE: -2 INCHI: InChI=1S/C17H27N3O17P2/c1-6(22)18-10-13(26)11(24)7(4-21)35-16(10)36-39(31,32)37-38(29,30)33-5-8-12(25)14(27)15(34-8)20-3-2-9(23)19-17(20)28/h2-3,7-8,10-16,21,24-27H,4-5H2,1H3,(H,18,22)(H,29,30)(H,31,32)(H,19,23,28)/p-2/t7-,8-,10-,11+,12-,13-,14-,15-,16?/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00190 EHMN_ABBREVIATION: C00203
has only substance units: false
name: UDP-N-acetyl-D-galactosamine(2-)

metaR RE1518M
notes: GENE_ASSOCIATION: (33.1) or (51.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.99.13 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:11356167,PMID:8973539 NOTES:
modifier: MODEL1310110045#
name: RE1518
is version of: http://identifiers.org/ec-code/1.3.3.6
kinetic law: MODEL1310110045#
product: MODEL1310110045#
reversible: true
is described by: ECO:0000000
fast: false
reactant: MODEL1310110045#
is version of: http://identifiers.org/ec-code/1.3.99.13
type: Reaction
is: SBO:0000176

metaR MTHFD2
is version of: http://identifiers.org/ec-code/3.5.4.9
type: Reaction
modifier: MODEL1310110045#
notes: GENE_ASSOCIATION: (100287639.1) or (441024.1) SUBSYSTEM: Folate metabolism EC Number: 1.5.1.5 Confidence Level: 2 AUTHORS: PMID:2786332 NOTES:NCD
is: SBO:0000176
reactant: MODEL1310110045#
product: MODEL1310110045#
reversible: true
kinetic law: MODEL1310110045#
is described by: ECO:0000134
fast: false
name: methylenetetrahydrofolate dehydrogenase (NAD)

http://identifiers.org/biomodels.db/MODEL1310110045#_a2f7cb70_12d5_4cf3_898b_4ca7249571c7
type: Species
boundary condition: true
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:AI761708
constant: false
has only substance units: false
initial concentration: NaN
name: _AI761708_1_m

metaM Nacasp c
notes: FORMULA: C6H7NO5 CHARGE: -2 INCHI: InChI=1S/C6H9NO5/c1-3(8)7-4(6(11)12)2-5(9)10/h4H,2H2,1H3,(H,7,8)(H,9,10)(H,11,12)/p-2/t4-/m0/s1 EHMN_ABBREVIATION: C01042
constant: false
boundary condition: false
initial concentration: 1.0
is: SBO:0000247
is: CHEBI:16953
has only substance units: false
is: HMDB00812
name: N-acetyl-L-aspartate(2-)
type: Species
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110045#_e25adb98_bdc1_419b_b2e8_c7f6af632374
constant: false
name: RDH14
is: Q9HBH5
is: SBO:0000252
initial concentration: NaN
initial amount: NaN
boundary condition: true
type: Species
is encoded by: hsa:57665
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110045#_3253f081_4878_40d5_b82d_04bf38b3ef2b
is: SBO:0000252
constant: false
type: Species
initial amount: NaN
is encoded by: hsa:6568
initial concentration: NaN
is: Q14916
boundary condition: true
has only substance units: false
name: SLC17A1

metaR MALtm
is described by: ECO:0000269
name: malate transport, mitochondrial
fast: false
type: Reaction
is: SBO:0000185
notes: GENE_ASSOCIATION: (1468.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172 NOTES:IF
reactant: MODEL1310110045#
kinetic law: MODEL1310110045#
reversible: true
modifier: MODEL1310110045#
product: MODEL1310110045#

metaR PRODt2r
is described by: ECO:0000304
type: Reaction
name: D-proline reversible transport via proton symport
fast: false
reversible: true
product: MODEL1310110045#
is: SBO:0000185
kinetic law: MODEL1310110045#
notes: GENE_ASSOCIATION: (206358.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11390972,PMID:11959859 NOTES:NCD SAB D form
modifier: MODEL1310110045#
reactant: MODEL1310110045#

metaR r2371
is: SBO:0000185
is described by: ECO:0000000
product: MODEL1310110045#
type: Reaction
kinetic law: MODEL1310110045#
reversible: true
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
reactant: MODEL1310110045#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110045#_139211f0_1a7c_44ff_b132_39e3e1d57db7
is: SBO:0000297
has part: Q9UHI5
is encoded by: hsa:23428
initial concentration: NaN
type: Species
initial amount: NaN
constant: false
boundary condition: true
has only substance units: false
name: SLC7A8:SLC3A2

http://identifiers.org/biomodels.db/MODEL1310110045#_a0b17bba_8a89_46c1_9339_14e2c420d0a6
initial amount: NaN
name: COL4A3BP
is encoded by: hsa:10087
is: Q9Y5P4
has only substance units: false
boundary condition: true
type: Species
initial concentration: NaN
constant: false
is: SBO:0000252

metaM bildglcur c
notes: FORMULA: C45H50N4O18 CHARGE: -2 INCHI: InChI=1S/C45H52N4O18/c1-7-20-19(6)40(58)49-27(20)14-25-18(5)23(10-12-31(51)65-45-37(57)33(53)35(55)39(67-45)43(62)63)29(47-25)15-28-22(17(4)24(46-28)13-26-16(3)21(8-2)41(59)48-26)9-11-30(50)64-44-36(56)32(52)34(54)38(66-44)42(60)61/h7-8,13-14,32-39,44-47,52-57H,1-2,9-12,15H2,3-6H3,(H,48,59)(H,49,58)(H,60,61)(H,62,63)/p-2/b26-13+,27-14+/t32-,33-,34-,35-,36+,37+,38-,39-,44+,45+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01616 EHMN_ABBREVIATION: C05787
name: bis(beta-glucosyluronate)bilirubin
initial amount: NaN
constant: false
is: SBO:0000247
is: HMDB03325
boundary condition: false
has only substance units: false
initial concentration: 1.0
type: Species
is: CHEBI:58471

metaR EX C04849 LPAREN e RPAREN
kinetic law: MODEL1310110045#
reactant: MODEL1310110045#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: (5Z,9E,14Z)-(8xi,11R,12S)-11,12-epoxy-8-hydroxyicosa-5,9,14-trienoate exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110045#_ade29f8f_4ffa_4ea7_89b6_81327e37aa0c
is: Q8IX04
type: Species
boundary condition: true
constant: false
is: SBO:0000252
initial concentration: NaN
initial amount: NaN
has only substance units: false
is encoded by: hsa:55293
name: UEVLD

metaR r0892
kinetic law: MODEL1310110045#
is described by: ECO:0000000
modifier: MODEL1310110045#
type: Reaction
is: SBO:0000185
reversible: true
fast: false
is version of: http://identifiers.org/ec-code/3.1.2.27
reactant: MODEL1310110045#
name: Facilitated diffusion
notes: GENE_ASSOCIATION: (10005.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:179827,PMID:9305892 NOTES:
product: MODEL1310110045#

metaM ksi pre21 g
initial concentration: 1.0
is: C00130
notes: FORMULA: C177H284N12O145S6X CHARGE: -7
constant: false
initial amount: NaN
is: HMDB00175
is: SBO:0000247
is: CHEBI:58053
has only substance units: false
name: keratan sulfate I biosynthesis, precursor 21
boundary condition: false
type: Species

metaR EX csn LPAREN e RPAREN
kinetic law: MODEL1310110045#
reactant: MODEL1310110045#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Cytosine exchange
type: Reaction

metaR PROSTGE2t2
is described by: ECO:0000269
modifier: MODEL1310110045#
product: MODEL1310110045#
notes: GENE_ASSOCIATION: (6582.2) or (6582.1) or (6580.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12827517,PMID:12883891,PMID:9187257 NOTES:electrogenic, Na indepdendent & rev NJ
fast: false
reversible: true
kinetic law: MODEL1310110045#
type: Reaction
reactant: MODEL1310110045#
name: prostaglandin uniport
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110045#_d322feb5_1810_4faf_946e_0be5fac3a02e
is encoded by: hsa:60386
is: SBO:0000252
name: SLC25A19
initial concentration: NaN
boundary condition: true
constant: false
has only substance units: false
initial amount: NaN
is: Q9HC21
type: Species

http://identifiers.org/biomodels.db/MODEL1310110045#_2a26a202_1419_41ff_a9fd_62150510aa26
boundary condition: true
constant: false
is: P04745
is encoded by: hsa:277
name: AMY1B
initial concentration: NaN
is: SBO:0000252
initial amount: NaN
has only substance units: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110045#_188ecb77_3c4c_423c_9355_92020f87b772
is: Q9H2F3
type: Species
boundary condition: true
constant: false
initial concentration: NaN
is encoded by: hsa:80270
is: SBO:0000252
name: HSD3B7
initial amount: NaN
has only substance units: false

metaR EX acald LPAREN e RPAREN
kinetic law: MODEL1310110045#
reactant: MODEL1310110045#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Acetaldehyde exchange
type: Reaction

metaM mi13p c
name: 1D-myo-Inositol 1,3-bisphosphate
notes: FORMULA: C6H10O12P2 CHARGE: -4 INCHI: InChI=1S/C6H14O12P2/c7-1-2(8)5(17-19(11,12)13)4(10)6(3(1)9)18-20(14,15)16/h1-10H,(H2,11,12,13)(H2,14,15,16)/t1-,2-,3+,4+,5+,6-
initial concentration: 1.0
initial amount: NaN
is: HMDB06234
boundary condition: false
is: SBO:0000247
constant: false
is: CHEBI:18225
type: Species
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110045#_8cc3f3e9_387f_4549_8266_92a54f5b8ad9
type: Species
initial amount: NaN
initial concentration: NaN
is: Q6FG42
constant: false
has only substance units: false
is encoded by: hsa:4701
is: SBO:0000252
name: NDUFA7
boundary condition: true

metaM bildglcur e
boundary condition: false
initial concentration: 1.0
notes: FORMULA: C45H50N4O18 CHARGE: -2 INCHI: InChI=1S/C45H52N4O18/c1-7-20-19(6)40(58)49-27(20)14-25-18(5)23(10-12-31(51)65-45-37(57)33(53)35(55)39(67-45)43(62)63)29(47-25)15-28-22(17(4)24(46-28)13-26-16(3)21(8-2)41(59)48-26)9-11-30(50)64-44-36(56)32(52)34(54)38(66-44)42(60)61/h7-8,13-14,32-39,44-47,52-57H,1-2,9-12,15H2,3-6H3,(H,48,59)(H,49,58)(H,60,61)(H,62,63)/p-2/b26-13+,27-14+/t32-,33-,34-,35-,36+,37+,38-,39-,44+,45+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01616 EHMN_ABBREVIATION: C05787
initial amount: NaN
constant: false
name: bis(beta-glucosyluronate)bilirubin
type: Species
is: SBO:0000247
is: CHEBI:58471
is: HMDB03325
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110045#_4cf9d91c_8029_4b47_833d_055b4b8ce331
initial amount: NaN
is: SBO:0000252
has only substance units: false
constant: false
name: _R33828_1_c
type: Species
initial concentration: NaN
is encoded by: hsa:R33828
boundary condition: true

metaM chol n
is: CHEBI:15354
has only substance units: false
initial amount: NaN
notes: FORMULA: C5H14NO CHARGE: 1 INCHI: InChI=1S/C5H14NO/c1-6(2,3)4-5-7/h7H,4-5H2,1-3H3/q+1 HEPATONET_1.0_ABBREVIATION: HC00112 EHMN_ABBREVIATION: C00114
name: choline
is: HMDB00097
initial concentration: 1.0
is: SBO:0000247
type: Species
constant: false
boundary condition: false

metaM 3aib D m
has only substance units: false
initial amount: NaN
constant: false
type: Species
is: HMDB02299
is: C03265
is: SBO:0000247
initial concentration: 1.0
notes: FORMULA: C4H9NO2 CHARGE: 0 INCHI: InChI=1/C4H9NO2/c1-3(2-5)4(6)7/h3H,2,5H2,1H3,(H,6,7)/t3-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00715
name: D-3-Amino-isobutanoate
boundary condition: false

metaR NACHEXA21ly
fast: false
modifier: MODEL1310110045#
kinetic law: MODEL1310110045#
name: beta-N-acetylhexosaminidase A, lysosomal
reactant: MODEL1310110045#
is version of: http://identifiers.org/ec-code/3.2.1.52
reversible: false
product: MODEL1310110045#
is described by: ECO:0000000
type: Reaction
is: SBO:0000176
notes: GENE_ASSOCIATION: (3073.1) or (3073.1 and 3074.1) SUBSYSTEM: Keratan sulfate degradation EC Number: Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12706724,PMID:8993162 NOTES:Note that this reaction is specific to beta-N-acetylhexosaminidase A and cannot be catalyzed by beta-N-acetylhexosaminidase B (or presumably beta-N-acetylhexosaminidase S). This is also a lumped reaction, representing the cleavage of GalNAc4S or GalNAc6S and N-acetylgalactosamine 4-sulfatase or 6-sulfatase. NCD

http://identifiers.org/biomodels.db/MODEL1310110045#_6d3cd8d3_3724_49f2_a547_8655ad0ef27c
is encoded by: hsa:AF116616
has only substance units: false
boundary condition: true
is: SBO:0000252
initial amount: NaN
constant: false
type: Species
name: _AF116616_1_m
initial concentration: NaN

metaM retinal cis 13 r
is: SBO:0000247
has only substance units: false
notes: FORMULA: C20H28O CHARGE: 0 INCHI: InChI=1S/C20H28O/c1-16(8-6-9-17(2)13-15-21)11-12-19-18(3)10-7-14-20(19,4)5/h6,8-9,11-13,15H,7,10,14H2,1-5H3/b9-6+,12-11+,16-8+,17-13- EHMN_ABBREVIATION: CE5589
is: HMDB06220
constant: false
initial amount: NaN
name: 13-cis-retinal
boundary condition: false
is: CHEBI:45487
initial concentration: 1.0
type: Species

metaR LTC4CP
notes: GENE_ASSOCIATION: SUBSYSTEM: Eicosanoid metabolism EC Number: 2.3.2.2 Confidence Level: 2 AUTHORS: PMID:12729612 NOTES:Converts leukotriene C4 (LTC4) to leukotriene F4 (LTF4). NJ
type: Reaction
kinetic law: MODEL1310110045#
fast: false
reversible: true
reactant: MODEL1310110045#
product: MODEL1310110045#
name: Leukotriene C4 carboxypeptidase
is: SBO:0000176
is described by: ECO:0000000

metaR 34HPPte
type: Reaction
kinetic law: MODEL1310110045#
fast: false
product: MODEL1310110045#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
reversible: true
is described by: ECO:0000134
reactant: MODEL1310110045#
name: Transport of 3-(4-hydroxyphenyl)pyruvate
is: SBO:0000185

metaR OXAtp
reactant: MODEL1310110045#
type: Reaction
product: MODEL1310110045#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: PMID:15240345 NOTES:NCD
fast: false
kinetic law: MODEL1310110045#
name: oxalate transport out of peroxisome
is described by: ECO:0000000
is: SBO:0000185
reversible: false

metaR GCC2cm
reversible: true
is version of: http://identifiers.org/ec-code/1.4.4.2
fast: false
reactant: MODEL1310110045#
name: glycine-cleavage complex (lipoamide), mitochondrial
is version of: http://identifiers.org/ec-code/1.8.1.4
modifier: MODEL1310110045#
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/2.1.2.10
notes: GENE_ASSOCIATION: (275.1) and (1738.1) and (2731.1) and (2653.1) SUBSYSTEM: Glycine, serine, alanine and threonine metabolism EC Number: 2.1.2.10 Confidence Level: 4 AUTHORS: PMID:15355973 NOTES:NCD
product: MODEL1310110045#
is: SBO:0000176
type: Reaction
kinetic law: MODEL1310110045#

http://identifiers.org/biomodels.db/MODEL1310110045#_7d7de136_bc70_4e5d_9df1_294d00ebd311
name: HK1
is: SBO:0000252
type: Species
is encoded by: hsa:3098
initial concentration: NaN
boundary condition: true
is: P19367
has only substance units: false
constant: false
initial amount: NaN

metaR r2142
kinetic law: MODEL1310110045#
reactant: MODEL1310110045#
reversible: true
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.14
fast: false
type: Reaction
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
modifier: MODEL1310110045#
product: MODEL1310110045#
is: SBO:0000185
is described by: ECO:0000000

metaM c226coa m
has only substance units: false
boundary condition: false
is: http://identifiers.org/pubchem.compound/47205479
is: C16169
name: cervonyl coenzyme A
initial amount: NaN
is: SBO:0000247
initial concentration: 1.0
constant: false
notes: FORMULA: C43H62N7O17P3S CHARGE: -4 INCHI: InChI=1/C43H66N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-34(52)71-27-26-45-33(51)24-25-46-41(55)38(54)43(2,3)29-64-70(61,62)67-69(59,60)63-28-32-37(66-68(56,57)58)36(53)42(65-32)50-31-49-35-39(44)47-30-48-40(35)50/h5-6,8-9,11-12,14-15,17-18,20-21,30-32,36-38,42,53-54H,4,7,10,13,16,19,22-29H2,1-3H3,(H,45,51)(H,46,55)(H,59,60)(H,61,62)(H2,44,47,48)(H2,56,57,58)/b6-5-,9-8-,12-11-,15-14-,18-17-,21-20-/t32-,36-,37-,38?,42-/m1/s1
type: Species

metaM chol m
boundary condition: false
initial amount: NaN
is: CHEBI:15354
is: HMDB00097
notes: FORMULA: C5H14NO CHARGE: 1 INCHI: InChI=1S/C5H14NO/c1-6(2,3)4-5-7/h7H,4-5H2,1-3H3/q+1 HEPATONET_1.0_ABBREVIATION: HC00112 EHMN_ABBREVIATION: C00114
name: choline
is: SBO:0000247
type: Species
constant: false
initial concentration: 1.0
has only substance units: false

metaR CHOLATEt
product: MODEL1310110045#
kinetic law: MODEL1310110045#
name: cholate transport via bicarbonate countertransport
is described by: ECO:0000269
is: SBO:0000185
reactant: MODEL1310110045#
notes: GENE_ASSOCIATION: (6579.1) or (10599.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12507753,PMID:9007731,PMID:9334206 NOTES:NJ
type: Reaction
reversible: true
fast: false
modifier: MODEL1310110045#

http://identifiers.org/biomodels.db/MODEL1310110045#_dd51164d_2cc4_4abe_99a8_bb3a5e6e054c
type: Species
initial amount: NaN
is encoded by: hsa:AL050025
constant: false
is: SBO:0000252
has only substance units: false
initial concentration: NaN
name: _AL050025_1_c
boundary condition: true

metaR EX HC00250 LPAREN e RPAREN
kinetic law: MODEL1310110045#
reactant: MODEL1310110045#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of hydrosulfide
type: Reaction

metaR C204CRNt
is described by: ECO:0000000
kinetic law: MODEL1310110045#
type: Reaction
reactant: MODEL1310110045#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: PMID:14598172 NOTES:TDV C20:4 transport
reversible: false
name: arachidonic acid transport into the mitochondria
is: SBO:0000185
product: MODEL1310110045#

http://identifiers.org/biomodels.db/MODEL1310110045#_7317fe3e_246b_44c9_9f50_450f3493d2aa
has only substance units: false
type: Species
initial amount: NaN
initial concentration: NaN
is: SBO:0000252
constant: false
is encoded by: hsa:622
boundary condition: true
name: BDH1

http://identifiers.org/biomodels.db/MODEL1310110045#_7ed3c047_ea0a_43a2_8f16_446cf87afb8d
initial amount: NaN
is: SBO:0000252
boundary condition: true
name: UGCG
initial concentration: NaN
type: Species
has only substance units: false
is: Q16739
is encoded by: hsa:7357
constant: false

metaM btcoa m
is: C00136
name: Butanoyl-CoA
boundary condition: false
is: HMDB01088
type: Species
constant: false
is: SBO:0000247
initial concentration: 1.0
notes: FORMULA: C25H38N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00134 EHMN_ABBREVIATION: C00136
has only substance units: false
initial amount: NaN
is: CHEBI:57371

metaR r2145
kinetic law: MODEL1310110045#
reversible: true
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.14
type: Reaction
product: MODEL1310110045#
fast: false
is: SBO:0000185
reactant: MODEL1310110045#
modifier: MODEL1310110045#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110045#_4a70ece5_a489_4e7b_b18b_1ddcee1d66d4
boundary condition: true
is: SBO:0000252
is encoded by: hsa:1103
type: Species
initial concentration: NaN
initial amount: NaN
has only substance units: false
constant: false
name: CHAT
is: Q6LEN6

metaM nm4masn g
has only substance units: false
initial concentration: 1.0
initial amount: NaN
type: Species
constant: false
boundary condition: false
notes: FORMULA: C54H90N3O40X CHARGE: 0
is: C05882
name: (N-acetyl-D-glucosaminyl-(alpha-D-mannosyl)4-beta-D-mannosyl-diacetylchitobiosyl)-L-asparagine (protein)
is: SBO:0000247

metaR TRPt
name: L-tryptophan transport
is described by: ECO:0000269
kinetic law: MODEL1310110045#
is: SBO:0000185
product: MODEL1310110045#
notes: GENE_ASSOCIATION: (117247.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:11827462 NOTES:
modifier: MODEL1310110045#
type: Reaction
reactant: MODEL1310110045#
reversible: true
fast: false

metaR r0670
name: (S)-3-Methyl-2-oxopentanoate:[dihydrolipoyllysine-residue (2-methylpropanoyl)transferase] lipoyllysine 2-oxidoreductase (decarboxylating, acceptor-2-methylpropanoylating) EC:1.2.4.4
type: Reaction
product: MODEL1310110045#
reactant: MODEL1310110045#
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 1.2.4.4 Confidence Level: 0 AUTHORS: PMID:11839747,PMID:12387880,PMID:15576032 NOTES:
fast: false
kinetic law: MODEL1310110045#
is: SBO:0000176
is described by: ECO:0000000
reversible: false

metaR TRPHYDRO2
modifier: MODEL1310110045#
type: Reaction
is version of: http://identifiers.org/ec-code/1.14.16.4
reversible: false
reactant: MODEL1310110045#
fast: false
product: MODEL1310110045#
notes: GENE_ASSOCIATION: (7166.1) or (121278.1) SUBSYSTEM: Tryptophan metabolism EC Number: 1.14.16.4 Confidence Level: 4 AUTHORS: PMID:10727395,PMID:12379098 NOTES:SAB unlumped version of TRPHYDRO1
is described by: ECO:0000269
name: L-Tryptophan,tetrahydrobiopterin:oxygen oxidoreductase (5-hydroxylating)
kinetic law: MODEL1310110045#
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110045#_cc027482_c7c3_44db_b2c1_db7d215a4f49
is: SBO:0000252
type: Species
initial amount: NaN
boundary condition: true
constant: false
is encoded by: hsa:55350
has only substance units: false
initial concentration: NaN
name: VNN3

metaM 2ddecdicoa m
is: SBO:0000247
name: 2,6-dodecadienoylcoa
is: HMDB11123
initial amount: NaN
boundary condition: false
initial concentration: 1.0
notes: FORMULA: C33H50N7O17P3S CHARGE: -4
has only substance units: false
type: Species
is: C05279
constant: false

http://identifiers.org/biomodels.db/MODEL1310110045#_a7a8a69d_59ab_4611_8812_ef5c19633943
boundary condition: true
has only substance units: false
constant: false
name: NME2
is: P22392
is encoded by: hsa:4831
type: Species
initial amount: NaN
is: SBO:0000252
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110045#_34009d4f_977f_4a3a_bf2d_5065a300a257
constant: false
initial concentration: NaN
name: NDUFB10
has only substance units: false
is: A8K761
initial amount: NaN
boundary condition: true
is: SBO:0000252
is encoded by: hsa:4716
type: Species

metaR r2144
type: Reaction
kinetic law: MODEL1310110045#
reversible: true
fast: false
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.14
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
modifier: MODEL1310110045#
is: SBO:0000185
is described by: ECO:0000000
reactant: MODEL1310110045#
product: MODEL1310110045#

http://identifiers.org/biomodels.db/MODEL1310110045#_ee686ae0_8e18_4b69_88de_55d4c872ef26
is encoded by: hsa:6580
boundary condition: true
constant: false
has only substance units: false
is: SBO:0000252
type: Species
is: O15245
initial amount: NaN
initial concentration: NaN
name: SLC22A1

metaM 4mop e
name: 4-methyl-2-oxopentanoate
is: SBO:0000247
has only substance units: false
is: HMDB00695
notes: FORMULA: C6H9O3 CHARGE: -1 INCHI: InChI=1S/C6H10O3/c1-4(2)3-5(7)6(8)9/h4H,3H2,1-2H3,(H,8,9)/p-1
initial concentration: 1.0
initial amount: NaN
is: CHEBI:17865
boundary condition: false
type: Species
constant: false

metaR HEXDIACTD
kinetic law: MODEL1310110045#
product: MODEL1310110045#
reactant: MODEL1310110045#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: transport of hexadecanedioc acid by diffusion
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110045#_e2bf883b_1688_4f9b_b282_6dc4974d519b
is encoded by: hsa:8608
is: SBO:0000252
boundary condition: true
constant: false
initial amount: NaN
name: RDH16
has only substance units: false
is: O75452
type: Species
initial concentration: NaN

metaR ACETONEt2m
is: SBO:0000185
type: Reaction
kinetic law: MODEL1310110045#
name: acetone mitochondrial transport via proton symport
modifier: MODEL1310110045#
is described by: ECO:0000000
fast: false
reversible: true
reactant: MODEL1310110045#
notes: GENE_ASSOCIATION: (6566.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: NOTES:NCD
product: MODEL1310110045#

http://identifiers.org/biomodels.db/MODEL1310110045#_9577838d_386d_4452_ac54_619d97b45b18
is: SBO:0000252
boundary condition: true
constant: false
initial concentration: NaN
initial amount: NaN
name: DUOX1
has only substance units: false
is encoded by: hsa:53905
type: Species

metaR DUDPtn
product: MODEL1310110045#
fast: false
reversible: true
reactant: MODEL1310110045#
kinetic law: MODEL1310110045#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: NOTES:IT
name: dUDP nuclear transport
is described by: ECO:0000000
is: SBO:0000185

metaM chol r
initial concentration: 1.0
has only substance units: false
boundary condition: false
is: HMDB00097
initial amount: NaN
type: Species
constant: false
notes: FORMULA: C5H14NO CHARGE: 1 INCHI: InChI=1S/C5H14NO/c1-6(2,3)4-5-7/h7H,4-5H2,1-3H3/q+1 HEPATONET_1.0_ABBREVIATION: HC00112 EHMN_ABBREVIATION: C00114
is: SBO:0000247
is: CHEBI:15354
name: choline

http://identifiers.org/biomodels.db/MODEL1310110045#_50366d89_9caa_4f65_918a_81062b03fc09
is: SBO:0000252
initial amount: NaN
initial concentration: NaN
type: Species
name: GALNT7
is encoded by: hsa:51809
is: Q86SF2
constant: false
boundary condition: true
has only substance units: false

metaM m6masnB2 g
name: (alpha-D-mannosyl)6-beta-D-mannosyl-diacetylchitobiosyl-L-asparagine (protein)
notes: FORMULA: C58H97N2O45X CHARGE: 0
has only substance units: false
type: Species
constant: false
is: HMDB01356
is: CHEBI:57312
initial concentration: 1.0
initial amount: NaN
is: SBO:0000247
boundary condition: false

metaM dc2coa m
name: trans-Dec-2-enoyl-CoA
is: SBO:0000247
notes: FORMULA: C31H48N7O17P3S CHARGE: -4 EHMN_ABBREVIATION: C05275
initial concentration: 1.0
has only substance units: false
boundary condition: false
initial amount: NaN
is: CHEBI:61406
constant: false
type: Species

metaR r0224
product: MODEL1310110045#
name: 5,6,7,8-Tetrahydrofolate:NAD+ oxidoreductase One carbon pool by folate EC:1.5.1.3
type: Reaction
notes: GENE_ASSOCIATION: (6576.1) SUBSYSTEM: Folate metabolism EC Number: 1.5.1.3 Confidence Level: 0 AUTHORS: PMID:15153070,PMID:1631094,PMID:6882460 NOTES:
fast: false
modifier: MODEL1310110045#
reactant: MODEL1310110045#
kinetic law: MODEL1310110045#
is: SBO:0000176
is described by: ECO:0000000
reversible: false

metaR EX ctp LPAREN e RPAREN
kinetic law: MODEL1310110045#
reactant: MODEL1310110045#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of CTP(4-)
type: Reaction

metaR UMPK6n
reversible: true
modifier: MODEL1310110045#
product: MODEL1310110045#
is: SBO:0000176
name: UMP kinase (dCTP),nuclear
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
is described by: ECO:0000269
fast: false
reactant: MODEL1310110045#
is version of: http://identifiers.org/ec-code/2.7.4.14
kinetic law: MODEL1310110045#
type: Reaction

metaR EX crn LPAREN e RPAREN
kinetic law: MODEL1310110045#
reactant: MODEL1310110045#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for L-Carnitine
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110045#_c97b3ee7_8ffb_43a7_9656_147e69e96489
has part: P48728
name: DLD:GCSH:GLDC:AMT
boundary condition: true
is encoded by: hsa:2731
is encoded by: hsa:2653
is: SBO:0000297
initial concentration: NaN
type: Species
has part: P23378
is encoded by: hsa:1738
has part: P23434
initial amount: NaN
is encoded by: hsa:275
constant: false
has part: P09622
has only substance units: false

metaR EX 4abutn LPAREN e RPAREN
kinetic law: MODEL1310110045#
reactant: MODEL1310110045#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of 4-ammoniobutanal
type: Reaction

metaR EX thr L LPAREN e RPAREN
kinetic law: MODEL1310110045#
reactant: MODEL1310110045#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: L-Threonine exchange
type: Reaction

metaM 4mop c
name: 4-methyl-2-oxopentanoate
is: CHEBI:17865
constant: false
is: SBO:0000247
initial concentration: 1.0
type: Species
initial amount: NaN
notes: FORMULA: C6H9O3 CHARGE: -1 INCHI: InChI=1S/C6H10O3/c1-4(2)3-5(7)6(8)9/h4H,3H2,1-2H3,(H,8,9)/p-1 HEPATONET_1.0_ABBREVIATION: HC00211 EHMN_ABBREVIATION: C00233
boundary condition: false
has only substance units: false
is: HMDB00695

metaM ksi pre27 g
has only substance units: false
initial amount: NaN
notes: FORMULA: C205H328N14O171S8X CHARGE: -9
boundary condition: false
is: HMDB00175
constant: false
is: SBO:0000247
type: Species
name: keratan sulfate I biosynthesis, precursor 27
is: CHEBI:58053
is: C00130
initial concentration: 1.0

metaR RDH1a
fast: false
product: MODEL1310110045#
kinetic law: MODEL1310110045#
is version of: http://identifiers.org/ec-code/1.1.1.105
notes: GENE_ASSOCIATION: (157506.1) or (112724.1) or (145226.1) or (51109.1) or (195814.1) or (57665.1) or (50700.1) SUBSYSTEM: Vitamin A metabolism EC Number: 1.1.1.105 Confidence Level: 4 AUTHORS: PMID:12226107,PMID:12372410,PMID:12407145,PMID:1503811,PMID:15258582,PMID:15322982 NOTES:IT
reactant: MODEL1310110045#
is version of: http://identifiers.org/ec-code/1.1.1.300
is described by: ECO:0000269
name: retinol dehydrogenase (all-trans,NADPH)
modifier: MODEL1310110045#
reversible: true
type: Reaction
is: SBO:0000176

metaM lnlc r
is: CHEBI:30245
is: SBO:0000247
is: HMDB00673
initial concentration: 1.0
name: linoleate
constant: false
notes: FORMULA: C18H31O2 CHARGE: -1 INCHI: InChI=1S/C18H32O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20/h6-7,9-10H,2-5,8,11-17H2,1H3,(H,19,20)/p-1/b7-6-,10-9- HEPATONET_1.0_ABBREVIATION: HC00796 EHMN_ABBREVIATION: C01595
has only substance units: false
type: Species
boundary condition: false
initial amount: NaN

metaR r1602
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
fast: false
product: MODEL1310110045#
is: SBO:0000185
reactant: MODEL1310110045#
kinetic law: MODEL1310110045#
reversible: true
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
type: Reaction

metaR RE2541E
notes: GENE_ASSOCIATION: (9365.1) SUBSYSTEM: Miscellaneous EC Number: 3.2.1.31 Confidence Level: 0 AUTHORS: PMID:10191290 NOTES:
name: RE2541
type: Reaction
reversible: true
reactant: MODEL1310110045#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.2.1.31
fast: false
is described by: ECO:0000000
modifier: MODEL1310110045#
product: MODEL1310110045#
kinetic law: MODEL1310110045#

http://identifiers.org/biomodels.db/MODEL1310110045#_a1200694_b96b_4c43_854c_cc900c3acfee
has only substance units: false
initial amount: NaN
initial concentration: NaN
constant: false
is: P21953
name: BCKDHB
is encoded by: hsa:594
type: Species
boundary condition: true
is: SBO:0000252

metaR M13N4Tg
reversible: false
reactant: MODEL1310110045#
modifier: MODEL1310110045#
is described by: ECO:0000000
fast: false
is: SBO:0000176
kinetic law: MODEL1310110045#
is version of: http://identifiers.org/ec-code/2.4.1.145
type: Reaction
product: MODEL1310110045#
notes: GENE_ASSOCIATION: (11320.1) or (11282.2) or (11282.1) SUBSYSTEM: N-glycan synthesis EC Number: 2.4.1.145 Confidence Level: 0 AUTHORS: PMID:10024668,PMID:10372966 NOTES:NCD
name: alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase

metaR r1813
product: MODEL1310110045#
fast: false
modifier: MODEL1310110045#
is described by: ECO:0000000
kinetic law: MODEL1310110045#
name: Y+LAT2 Utilized transport
is: SBO:0000185
type: Reaction
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reversible: false
reactant: MODEL1310110045#

metaR r0226
type: Reaction
product: MODEL1310110045#
reversible: false
name: 5,6,7,8-Tetrahydrofolate:NADP+ oxidoreductase One carbon pool by folate / Folate biosynthesis EC:1.5.1.3
fast: false
reactant: MODEL1310110045#
modifier: MODEL1310110045#
is: SBO:0000176
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (6576.1) SUBSYSTEM: Folate metabolism EC Number: 1.5.1.3 Confidence Level: 0 AUTHORS: PMID:15153070,PMID:16171773,PMID:1631094,PMID:6882460,PMID:962851 NOTES:
kinetic law: MODEL1310110045#

metaR EX Lcystin LPAREN e RPAREN
kinetic law: MODEL1310110045#
reactant: MODEL1310110045#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: L-Cystine exchange
type: Reaction

metaM urate c
boundary condition: false
name: Urate
is: SBO:0000247
initial concentration: 1.0
has only substance units: false
constant: false
notes: FORMULA: C5H4N4O3 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00310 EHMN_ABBREVIATION: C00366
type: Species
is: C00366
is: CHEBI:17775
initial amount: NaN
is: HMDB00289

metaR GGH 6DHFl
is: SBO:0000176
fast: false
type: Reaction
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/3.4.19.9
modifier: MODEL1310110045#
product: MODEL1310110045#
reversible: false
notes: GENE_ASSOCIATION: (8836.1) SUBSYSTEM: Folate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:11375437,PMID:2867095,PMID:9614206 NOTES:REMOVES EITHER ONE OR TWO GLUTAMYL RESIDUES WITH A REACTION (WILL ONLY REPRESENT 1) IT
reactant: MODEL1310110045#
kinetic law: MODEL1310110045#
name: Gamma-glutamyl hydrolase (6DHF), lysosomal

metaR CYTK1m
is described by: ECO:0000134
fast: false
reversible: true
kinetic law: MODEL1310110045#
type: Reaction
reactant: MODEL1310110045#
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 1 AUTHORS: PMID:17999954 NOTES:No evidence in the mitochondrion
product: MODEL1310110045#
name: cytidylate kinase (CMP),mitochondrial

http://identifiers.org/biomodels.db/MODEL1310110045#_0d52ed6c_84fe_46cf_ae52_0fb4e774964d
initial concentration: NaN
type: Species
initial amount: NaN
boundary condition: true
constant: false
is: Q96QE2
is encoded by: hsa:114134
has only substance units: false
is: SBO:0000252
name: SLC2A13

metaR DTTPtn
type: Reaction
name: dTTP diffusion in nucleus
kinetic law: MODEL1310110045#
is described by: ECO:0000000
is: SBO:0000185
product: MODEL1310110045#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: NOTES:IT
fast: false
reversible: true
reactant: MODEL1310110045#

metaM e4p c
has only substance units: false
is: C00279
constant: false
name: D-Erythrose 4-phosphate
is: CHEBI:16897
is: HMDB01321
initial amount: NaN
notes: FORMULA: C4H7O7P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00247 EHMN_ABBREVIATION: C00279
initial concentration: 1.0
boundary condition: false
type: Species
is: SBO:0000247

metaR IMPC
is described by: ECO:0000269
reactant: MODEL1310110045#
is: SBO:0000176
product: MODEL1310110045#
reversible: true
is version of: http://identifiers.org/ec-code/2.1.2.3
type: Reaction
kinetic law: MODEL1310110045#
name: IMP cyclohydrolase
notes: GENE_ASSOCIATION: (471.1) SUBSYSTEM: Purine synthesis EC Number: 3.5.4.10 Confidence Level: 4 AUTHORS: PMID:11948179,PMID:14966129,PMID:9378707 NOTES:
modifier: MODEL1310110045#
fast: false

metaM ahcys c
notes: FORMULA: C14H20N6O5S CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00031 EHMN_ABBREVIATION: C00021
has only substance units: false
initial amount: NaN
boundary condition: false
initial concentration: 1.0
is: C00021
type: Species
is: CHEBI:16680
constant: false
is: SBO:0000247
name: S-Adenosyl-L-homocysteine
is: HMDB00939

metaR EX ppi LPAREN e RPAREN
kinetic law: MODEL1310110045#
reactant: MODEL1310110045#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for ppi
type: Reaction

metaR r1600
type: Reaction
is described by: ECO:0000000
fast: false
product: MODEL1310110045#
is: SBO:0000185
reactant: MODEL1310110045#
kinetic law: MODEL1310110045#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:

metaR CYTK1n
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
name: cytidylate kinase (CMP),nuclear
is version of: http://identifiers.org/ec-code/2.7.4.14
kinetic law: MODEL1310110045#
reactant: MODEL1310110045#
reversible: true
type: Reaction
product: MODEL1310110045#
is described by: ECO:0000269
modifier: MODEL1310110045#
fast: false
is: SBO:0000176

metaR r0899
is described by: ECO:0000000
name: Amino acid transporter ATB0+ Facilitated diffusion
reactant: MODEL1310110045#
is: SBO:0000185
reversible: true
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:10721894,PMID:11787643,PMID:12269802,PMID:12504794,PMID:16955229,PMID:17401668,PMID:18599538,PMID:3132542,PMID:487087,PMID:551321,PMID:6418146,PMID:7731061,PMID:8010975,PMID:8382624,PMID:8654117,PMID:8899554,PMID:911815,PMID:917262 NOTES:
product: MODEL1310110045#
kinetic law: MODEL1310110045#
type: Reaction

metaR UDPGALtg
product: MODEL1310110045#
fast: false
name: UDP-Gal Golgi transport via CMP antiport
modifier: MODEL1310110045#
reactant: MODEL1310110045#
reversible: true
kinetic law: MODEL1310110045#
notes: GENE_ASSOCIATION: (7355.1) SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 4 AUTHORS: PMID:11784306,PMID:8889805,PMID:9010752,PMID:9399569,PMID:9562625 NOTES:NCD
is: SBO:0000185
is described by: ECO:0000269
type: Reaction

metaM leuktrD4 c
name: Leukotriene D4
is: CHEBI:28666
boundary condition: false
notes: FORMULA: C25H39N2O6S CHARGE: -1 INCHI: InChI=1S/C25H40N2O6S/c1-2-3-4-5-6-7-8-9-10-11-12-13-16-22(21(28)15-14-17-23(29)30)34-19-20(26)25(33)27-18-24(31)32/h6-7,9-13,16,20-22,28H,2-5,8,14-15,17-19,26H2,1H3,(H,27,33)(H,29,30)(H,31,32)/b7-6-,10-9-,12-11+,16-13+/t20-,21-,22+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01664 EHMN_ABBREVIATION: C05951
constant: false
has only substance units: false
initial concentration: 1.0
type: Species
initial amount: NaN
is: SBO:0000247
is: HMDB03080

metaM c226coa c
initial concentration: 1.0
name: cervonyl coenzyme A
notes: FORMULA: C43H62N7O17P3S CHARGE: -4 INCHI: InChI=1/C43H66N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-34(52)71-27-26-45-33(51)24-25-46-41(55)38(54)43(2,3)29-64-70(61,62)67-69(59,60)63-28-32-37(66-68(56,57)58)36(53)42(65-32)50-31-49-35-39(44)47-30-48-40(35)50/h5-6,8-9,11-12,14-15,17-18,20-21,30-32,36-38,42,53-54H,4,7,10,13,16,19,22-29H2,1-3H3,(H,45,51)(H,46,55)(H,59,60)(H,61,62)(H2,44,47,48)(H2,56,57,58)/b6-5-,9-8-,12-11-,15-14-,18-17-,21-20-/t32-,36-,37-,38?,42-/m1/s1
constant: false
has only substance units: false
type: Species
boundary condition: false
is: SBO:0000247
is: C16169
initial amount: NaN
is: http://identifiers.org/pubchem.compound/47205479

metaM urate e
is: C00366
is: HMDB00289
constant: false
is: CHEBI:17775
boundary condition: false
name: Urate
type: Species
notes: FORMULA: C5H4N4O3 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00310 EHMN_ABBREVIATION: C00366
is: SBO:0000247
initial concentration: 1.0
initial amount: NaN
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110045#_855022bb_c47f_496f_9417_357da0626369
is: SBO:0000252
initial amount: NaN
has only substance units: false
type: Species
name: ADSL
boundary condition: true
is encoded by: hsa:158
constant: false
initial concentration: NaN

metaM sgalside hs c
is: SBO:0000247
initial amount: NaN
has only substance units: false
is: CHEBI:16523
constant: false
notes: FORMULA: C24H45NO10SFULLRCO CHARGE: -1
is: HMDB03406
initial concentration: 1.0
name: sulfatide galactocerebroside
type: Species
boundary condition: false

metaR DNDPt44m
type: Reaction
fast: false
modifier: MODEL1310110045#
is: SBO:0000185
kinetic law: MODEL1310110045#
name: dTTP transport via ATP antiport
is described by: ECO:0000269
product: MODEL1310110045#
notes: GENE_ASSOCIATION: (60386.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:11226231 NOTES:IT
reactant: MODEL1310110045#
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110045#_9dde34ca_8e1c_46df_8a8d_4bb5ed14428e
constant: false
is: Q9UFY1
type: Species
name: PLCG1
has only substance units: false
initial amount: NaN
boundary condition: true
is: SBO:0000252
is encoded by: hsa:5335
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110045#_74f8f144_8f69_4941_a308_a531ba63cf61
name: FPGT
is encoded by: hsa:8790
has only substance units: false
initial amount: NaN
type: Species
boundary condition: true
constant: false
is: SBO:0000252
initial concentration: NaN
is: O14772

metaR DTDPtn
reactant: MODEL1310110045#
reversible: true
kinetic law: MODEL1310110045#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: NOTES:NCD
product: MODEL1310110045#
fast: false
is described by: ECO:0000000
type: Reaction
name: dTDP nuclear transport
is: SBO:0000185

metaM ksi deg5 l
constant: false
notes: FORMULA: C222H356N15O194S11 CHARGE: -11
initial concentration: 1.0
has only substance units: false
boundary condition: false
is: SBO:0000247
initial amount: NaN
is: HMDB00143
is: CHEBI:12936
type: Species
name: keratan sulfate I, degradation product 5

metaR CITt4 4
name: citrate transport via sodium symport
kinetic law: MODEL1310110045#
reactant: MODEL1310110045#
fast: false
type: Reaction
is: SBO:0000185
reversible: true
notes: GENE_ASSOCIATION: (284111.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12177002,PMID:12445824 NOTES:NCD
is described by: ECO:0000006
product: MODEL1310110045#
modifier: MODEL1310110045#

metaM hxan e
name: hypoxanthine
initial concentration: 1.0
is: HMDB00157
is: CHEBI:17368
notes: FORMULA: C5H4N4O CHARGE: 0 INCHI: InChI=1S/C5H4N4O/c10-5-3-4(7-1-6-3)8-2-9-5/h1-2H,(H2,6,7,8,9,10) HEPATONET_1.0_ABBREVIATION: HC00238 EHMN_ABBREVIATION: C00262
constant: false
type: Species
boundary condition: false
is: SBO:0000247
has only substance units: false
initial amount: NaN

metaR r1605
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
type: Reaction
reactant: MODEL1310110045#
fast: false
is described by: ECO:0000000
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
kinetic law: MODEL1310110045#
reversible: true
is: SBO:0000185
product: MODEL1310110045#

metaR NADNe
product: MODEL1310110045#
is version of: http://identifiers.org/ec-code/3.2.2.5
modifier: MODEL1310110045#
reversible: false
type: Reaction
reactant: MODEL1310110045#
kinetic law: MODEL1310110045#
fast: false
name: NAD nucleosidase,extracellular
is: SBO:0000176
notes: GENE_ASSOCIATION: (952.1) SUBSYSTEM: NAD metabolism EC Number: 3.2.2.5 Confidence Level: 4 AUTHORS: PMID:8394137 NOTES:
is described by: ECO:0000269

metaR CH25H
kinetic law: MODEL1310110045#
name: cholesterol 25-hydroxylase
reversible: false
type: Reaction
is described by: ECO:0000269
is: SBO:0000176
reactant: MODEL1310110045#
product: MODEL1310110045#
modifier: MODEL1310110045#
is version of: http://identifiers.org/ec-code/1.14.99.38
fast: false
notes: GENE_ASSOCIATION: (9023.1) SUBSYSTEM: Bile acid synthesis EC Number: Confidence Level: 4 AUTHORS: NOTES:NJ

metaR AMETtd
fast: false
type: Reaction
reversible: true
kinetic law: MODEL1310110045#
is described by: ECO:0000134
name: diffusion of S-Adenosyl-L-methionine
reactant: MODEL1310110045#
product: MODEL1310110045#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: NOTES:

http://identifiers.org/biomodels.db/MODEL1310110045#_349bbfbb_0484_4465_bb59_495ecad71a19
initial concentration: NaN
name: SLC2A10
is: SBO:0000252
constant: false
has only substance units: false
is encoded by: hsa:81031
boundary condition: true
type: Species
is: O95528
initial amount: NaN

metaM ksii core2 pre3 g
boundary condition: false
notes: FORMULA: C47H76N4O33X CHARGE: -1
initial amount: NaN
is: C00130
has only substance units: false
constant: false
initial concentration: 1.0
type: Species
is: SBO:0000247
is: HMDB00175
name: keratan sulfate II biosynthesis, precursor 3
is: CHEBI:58053

metaM ahcys e
is: CHEBI:16680
initial amount: NaN
name: S-Adenosyl-L-homocysteine
is: SBO:0000247
is: HMDB00939
has only substance units: false
boundary condition: false
notes: FORMULA: C14H20N6O5S CHARGE: 0
type: Species
is: C00021
initial concentration: 1.0
constant: false

metaR r1606
is: SBO:0000185
product: MODEL1310110045#
reactant: MODEL1310110045#
reversible: true
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
type: Reaction
kinetic law: MODEL1310110045#
is described by: ECO:0000000

metaR ATP1ter
is: SBO:0000185
product: MODEL1310110045#
name: ADP/ATP transporter, endoplasmic reticulum
kinetic law: MODEL1310110045#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: NOTES:NCD
reactant: MODEL1310110045#
reversible: true
fast: false
type: Reaction
is described by: ECO:0000000

metaM ksii core4 pre6 g
is: SBO:0000247
boundary condition: false
initial concentration: 1.0
has only substance units: false
constant: false
initial amount: NaN
is: CHEBI:28067
type: Species
name: keratan sulfate II biosynthesis, precursor 6
notes: FORMULA: C69H111N6O51SX CHARGE: -2

metaM leuktrD4 e
type: Species
name: Leukotriene D4
has only substance units: false
is: SBO:0000247
is: HMDB03080
constant: false
initial concentration: 1.0
initial amount: NaN
boundary condition: false
notes: FORMULA: C25H39N2O6S CHARGE: -1 INCHI: InChI=1S/C25H40N2O6S/c1-2-3-4-5-6-7-8-9-10-11-12-13-16-22(21(28)15-14-17-23(29)30)34-19-20(26)25(33)27-18-24(31)32/h6-7,9-13,16,20-22,28H,2-5,8,14-15,17-19,26H2,1H3,(H,27,33)(H,29,30)(H,31,32)/b7-6-,10-9-,12-11+,16-13+/t20-,21-,22+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01664 EHMN_ABBREVIATION: C05951
is: CHEBI:28666

http://identifiers.org/biomodels.db/MODEL1310110045#_268ddc34_f632_4205_abb2_5d6def82840a
initial concentration: NaN
is encoded by: hsa:80025
has only substance units: false
boundary condition: true
type: Species
constant: false
is: SBO:0000252
initial amount: NaN
name: PANK2

metaR TYRt4
is: SBO:0000185
reactant: MODEL1310110045#
is described by: ECO:0000304
name: L-tyrosine transport in via sodium symport
type: Reaction
fast: false
product: MODEL1310110045#
modifier: MODEL1310110045#
kinetic law: MODEL1310110045#
reversible: false
notes: GENE_ASSOCIATION: (11254.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11133652,PMID:12719981 NOTES:SAB

http://identifiers.org/biomodels.db/MODEL1310110045#_48c0e376_fce2_44cd_b2da_fbdc77b096e7
is: F5GZG6
initial amount: NaN
boundary condition: true
is encoded by: hsa:27010
type: Species
constant: false
has only substance units: false
name: TPK1
initial concentration: NaN
is: SBO:0000252

metaM dhdascb e
is: HMDB01264
is: CHEBI:58070
constant: false
notes: FORMULA: C6H6O6 CHARGE: 0 INCHI: InChI=1S/C6H5O6/c7-1-2(8)5-3(9)4(10)6(11)12-5/h2,7-8H,1H2/q-1 EHMN_ABBREVIATION: C00425
initial amount: NaN
initial concentration: 1.0
has only substance units: false
type: Species
boundary condition: false
name: dehydroascorbide(1-)
is: SBO:0000247

metaR FAOXC15ATPx
kinetic law: MODEL1310110045#
product: MODEL1310110045#
reactant: MODEL1310110045#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid activation(C15)x
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110045#_5694bdbb_5708_42a2_9d85_4e9c377a86d2
has only substance units: false
constant: false
initial amount: NaN
boundary condition: true
name: _AU149534_1_c
initial concentration: NaN
type: Species
is: SBO:0000252
is encoded by: hsa:AU149534

metaR EX tdchola LPAREN e RPAREN
kinetic law: MODEL1310110045#
reactant: MODEL1310110045#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: taurochenodeoxycholate exchange
type: Reaction

metaR LNLNCAt
reactant: MODEL1310110045#
kinetic law: MODEL1310110045#
name: fatty acid transport via diffusion
type: Reaction
is: SBO:0000185
product: MODEL1310110045#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11788354,PMID:12864740 NOTES:NJ
reversible: true
is described by: ECO:0000000

metaM hxan c
initial concentration: 1.0
is: C00262
initial amount: NaN
boundary condition: false
has only substance units: false
name: Hypoxanthine
type: Species
constant: false
notes: FORMULA: C5H4N4O CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00238 EHMN_ABBREVIATION: C00262
is: SBO:0000247
is: HMDB00157
is: CHEBI:17368

metaR r1603
type: Reaction
reactant: MODEL1310110045#
fast: false
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is described by: ECO:0000000
kinetic law: MODEL1310110045#
reversible: true
product: MODEL1310110045#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is: SBO:0000185

metaM 2hexdtetcoa m
has only substance units: false
is: HMDB02288
name: 2,7,10,13-hexadecatetraenoylcoa
boundary condition: false
initial concentration: 1.0
initial amount: NaN
type: Species
notes: FORMULA: C37H54N7O17P3S CHARGE: -4
constant: false
is: SBO:0000247

metaR ETF
notes: GENE_ASSOCIATION: (2109.2) and (2108.1) or (2109.1) and (2108.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: PMID:3170610,PMID:7601336 NOTES:TV (5/4/05) Voet p.571
is described by: ECO:0000000
reactant: MODEL1310110045#
reversible: false
kinetic law: MODEL1310110045#
fast: false
is: SBO:0000176
type: Reaction
product: MODEL1310110045#
name: electron transfer flavoprotein
modifier: MODEL1310110045#

metaM ddcacoa x
notes: FORMULA: C33H54N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00850 EHMN_ABBREVIATION: C01832
is: HMDB03571
is: CHEBI:57375
is: C01832
initial amount: NaN
boundary condition: false
has only substance units: false
name: Dodecanoyl-CoA (n-C12:0CoA)
constant: false
type: Species
initial concentration: 1.0
is: SBO:0000247

metaR XOLTRIOLtm
is described by: ECO:0000000
is: SBO:0000185
kinetic law: MODEL1310110045#
type: Reaction
reversible: true
name: lipid, flip-flop intracellular transport
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: PMID:12840657 NOTES:cholesterol precursor, transport by "diffusion" -> actually beleived to be flip-flop mechanism (PMID: 12840657). NJ
fast: false
reactant: MODEL1310110045#
product: MODEL1310110045#

metaR RE3004M
is version of: http://identifiers.org/ec-code/2.3.1.16
kinetic law: MODEL1310110045#
type: Reaction
name: RE3004
is version of: http://identifiers.org/ec-code/4.2.1.17
reactant: MODEL1310110045#
modifier: MODEL1310110045#
reversible: true
is version of: http://identifiers.org/ec-code/1.1.1.35
notes: GENE_ASSOCIATION: (1892.1) or (3030.1) or (1962.1) or (3032.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.17 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:7775433 NOTES:
is described by: ECO:0000000
fast: false
is: SBO:0000176
product: MODEL1310110045#

metaR G14T19g
reactant: MODEL1310110045#
is version of: http://identifiers.org/ec-code/2.4.1.90
product: MODEL1310110045#
type: Reaction
is version of: http://identifiers.org/ec-code/2.4.1.22
reversible: false
is version of: http://identifiers.org/ec-code/2.4.1.38
notes: GENE_ASSOCIATION: (9334.1) or (8704.1) or (8703.1) or (8704.2) or (2683.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.38 Confidence Level: 4 AUTHORS: PMID:10747980,PMID:12512857,PMID:1903938,PMID:3094506,PMID:3144273,PMID:9405390,PMID:9435216 NOTES:Keratan sulfate II biosynthesis NCD
fast: false
modifier: MODEL1310110045#
is described by: ECO:0000000
kinetic law: MODEL1310110045#
is: SBO:0000176
name: beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase, Golgi

metaR EX ksii core4 LPAREN e RPAREN
kinetic law: MODEL1310110045#
reactant: MODEL1310110045#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: keratan sulfate II (core 4-linked) exchange
type: Reaction

metaR r1604
is described by: ECO:0000000
product: MODEL1310110045#
is: SBO:0000185
reversible: true
reactant: MODEL1310110045#
fast: false
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
kinetic law: MODEL1310110045#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110045#_dce3e009_958f_4e9e_bb53_0fec345e8e48
initial concentration: NaN
constant: false
type: Species
has only substance units: false
is: SBO:0000252
is: P16219
name: ACADS
is encoded by: hsa:35
initial amount: NaN
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110045#_d43fd38f_9439_430d_99ef_72638ff4117d
initial amount: NaN
boundary condition: true
is: SBO:0000252
is: P00325
is encoded by: hsa:125
constant: false
initial concentration: NaN
type: Species
has only substance units: false
name: ADH1B

http://identifiers.org/biomodels.db/MODEL1310110045#_bc05935a_3aa1_481b_8463_cc5b8d4e54f0
is encoded by: hsa:5337
initial concentration: NaN
name: PLD1
constant: false
is: Q59EA4
type: Species
initial amount: NaN
boundary condition: true
is: SBO:0000252
has only substance units: false

metaM mi145p c
notes: FORMULA: C6H9O15P3 CHARGE: -6 INCHI: InChI=1S/C6H15O15P3/c7-1-2(8)5(20-23(13,14)15)6(21-24(16,17)18)3(9)4(1)19-22(10,11)12/h1-9H,(H2,10,11,12)(H2,13,14,15)(H2,16,17,18)/p-6/t1-,2+,3+,4-,5-,6-/m1/s1 EHMN_ABBREVIATION: C01245
boundary condition: false
is: CHEBI:203600
initial concentration: 1.0
has only substance units: false
name: 1D-myo-inositol 1,4,5-trisphosphate(6-)
type: Species
is: SBO:0000247
constant: false
initial amount: NaN
is: HMDB01498

metaR DHORD9
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/1.3.5.2
notes: GENE_ASSOCIATION: (1723.1) SUBSYSTEM: Pyrimidine synthesis EC Number: 1.3.3.1 Confidence Level: 4 AUTHORS: PMID:10727948,PMID:9693067 NOTES:_06-15-05 - EC 1.3.3.1 IT based on Bader et al, 1998, Prot. Expr. Purif,., 13,414-422 (I guess it is ubiquinone but i am not sure ) (needs FMN as cofactor) v(enzyme is located in inner-membrane of mitochondria, reaction take place in cytosol (Fig. 8 Rawls et al PMID: 10727948 )
is: SBO:0000185
fast: false
modifier: MODEL1310110045#
type: Reaction
product: MODEL1310110045#
reversible: false
reactant: MODEL1310110045#
kinetic law: MODEL1310110045#
name: dihydoorotic acid dehydrogenase (quinone10)

metaR RE2759X
notes: GENE_ASSOCIATION: (23600.1) SUBSYSTEM: Fatty acid oxidation EC Number: 5.1.99.4 Confidence Level: 0 AUTHORS: PMID:11060344,PMID:11060359 NOTES:
modifier: MODEL1310110045#
type: Reaction
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/5.1.99.4
reversible: true
product: MODEL1310110045#
kinetic law: MODEL1310110045#
fast: false
is: SBO:0000176
name: RE2759
reactant: MODEL1310110045#

metaR r0669
kinetic law: MODEL1310110045#
is: SBO:0000176
fast: false
name: (S)-3-Hydroxyisobutyryl-CoA hydro-lyase Valine, leucine and isoleucine degradation EC:4.2.1.17
reactant: MODEL1310110045#
is described by: ECO:0000000
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 4.2.1.17 Confidence Level: 0 AUTHORS: PMID:10671535,PMID:12467702 NOTES:
product: MODEL1310110045#
reversible: false

metaR r1608
reactant: MODEL1310110045#
product: MODEL1310110045#
is: SBO:0000185
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
kinetic law: MODEL1310110045#
reversible: true
fast: false
type: Reaction
is described by: ECO:0000000

metaR It
is: SBO:0000185
modifier: MODEL1310110045#
product: MODEL1310110045#
reversible: true
notes: GENE_ASSOCIATION: (160728.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:1217270 NOTES:NCD
kinetic law: MODEL1310110045#
type: Reaction
reactant: MODEL1310110045#
fast: false
name: Iodide uniport
is described by: ECO:0000269

metaM dhcholestanate m
initial concentration: 1.0
is: CHEBI:16577
constant: false
initial amount: NaN
boundary condition: false
is: SBO:0000247
name: 3alpha,7alpha-Dihydroxy-5beta-cholestanate
is: HMDB00359
type: Species
notes: FORMULA: C27H45O4 CHARGE: -1 INCHI: InChI=1S/C27H46O4/c1-16(6-5-7-17(2)25(30)31)20-8-9-21-24-22(11-13-27(20,21)4)26(3)12-10-19(28)14-18(26)15-23(24)29/h16-24,28-29H,5-15H2,1-4H3,(H,30,31)/t16-,17?,18+,19-,20-,21+,22+,23-,24+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01313 EHMN_ABBREVIATION: C04554
has only substance units: false

metaM CE5118 m
notes: FORMULA: C35H52N7O17P3S CHARGE: -4 INCHI: InChI=1/C35H56N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-26(44)63-19-18-37-25(43)16-17-38-33(47)30(46)35(2,3)21-56-62(53,54)59-61(51,52)55-20-24-29(58-60(48,49)50)28(45)34(57-24)42-23-41-27-31(36)39-22-40-32(27)42/h8-9,12-15,22-24,28-30,34,45-46H,4-7,10-11,16-21H2,1-3H3,(H,37,43)(H,38,47)(H,51,52)(H,53,54)(H2,36,39,40)(H2,48,49,50)/p-4/b9-8-,13-12-,15-14+/t24-,28+,29+,30u,34-/m0/s1 EHMN_ABBREVIATION: CE5118
is: CHEBI:57923
initial concentration: 1.0
initial amount: NaN
has only substance units: false
name: trans-2-cis,cis-4,8-tetradecatrienoyl-CoA
type: Species
constant: false
boundary condition: false
is: SBO:0000247

metaM CE2418 m
boundary condition: false
name: (3S)-3-hydroxy-cis,cis-palmito-7,10-dienoyl-CoA
type: Species
has only substance units: false
initial concentration: 1.0
initial amount: NaN
notes: FORMULA: C37H58N7O18P3S CHARGE: -4 INCHI: InChI=1/C37H62N7O18P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-25(45)20-28(47)66-19-18-39-27(46)16-17-40-35(50)32(49)37(2,3)22-59-65(56,57)62-64(54,55)58-21-26-31(61-63(51,52)53)30(48)36(60-26)44-24-43-29-33(38)41-23-42-34(29)44/h8-9,11-12,23-26,30-32,36,45,48-49H,4-7,10,13-22H2,1-3H3,(H,39,46)(H,40,50)(H,54,55)(H,56,57)(H2,38,41,42)(H2,51,52,53)/p-4/b9-8-,12-11-/t25-,26-,30+,31+,32u,36-/m0/s1 EHMN_ABBREVIATION: CE2418
is: CHEBI:28387
constant: false
is: HMDB11123
is: SBO:0000247

metaM cholcoaone x
has only substance units: false
name: 3alpha,7alpha,12alpha-trihydroxy-24-oxo-5beta-cholestan-26-oyl-CoA(4-)
is: HMDB06891
notes: FORMULA: C48H74N7O21P3S CHARGE: -4 INCHI: InChI=1S/C48H78N7O21P3S/c1-24(28-8-9-29-36-30(19-34(59)48(28,29)6)47(5)13-11-27(56)17-26(47)18-32(36)58)7-10-31(57)25(2)45(64)80-16-15-50-35(60)12-14-51-43(63)40(62)46(3,4)21-73-79(70,71)76-78(68,69)72-20-33-39(75-77(65,66)67)38(61)44(74-33)55-23-54-37-41(49)52-22-53-42(37)55/h22-30,32-34,36,38-40,44,56,58-59,61-62H,7-21H2,1-6H3,(H,50,60)(H,51,63)(H,68,69)(H,70,71)(H2,49,52,53)(H2,65,66,67)/p-4/t24-,25?,26+,27-,28-,29+,30+,32-,33-,34+,36+,38-,39-,40+,44-,47+,48-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01473 EHMN_ABBREVIATION: C05467
initial concentration: 1.0
boundary condition: false
type: Species
is: SBO:0000247
constant: false
initial amount: NaN
is: CHEBI:58507

http://identifiers.org/biomodels.db/MODEL1310110045#_ba4e94aa_c6da_4b0c_9044_8a8309c1231e
initial amount: NaN
is: SBO:0000252
initial concentration: NaN
is: O76062
constant: false
type: Species
has only substance units: false
name: TM7SF2
boundary condition: true
is encoded by: hsa:7108

metaM arachd c
constant: false
initial amount: NaN
boundary condition: false
notes: FORMULA: C20H31O2 CHARGE: -1 INCHI: InChI=1S/C20H32O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20(21)22/h6-7,9-10,12-13,15-16H,2-5,8,11,14,17-19H2,1H3,(H,21,22)/p-1/b7-6-,10-9-,13-12-,16-15-
type: Species
initial concentration: 1.0
name: arachidonate
is: SBO:0000247
has only substance units: false
is: HMDB01043
is: CHEBI:32395

metaR MI1345PP
type: Reaction
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.1.3.86
is version of: http://identifiers.org/ec-code/3.1.3.36
fast: false
name: inositol-1,3,4,5-trisphosphate 5-phosphatase
modifier: MODEL1310110045#
kinetic law: MODEL1310110045#
reversible: false
is described by: ECO:0000269
product: MODEL1310110045#
notes: GENE_ASSOCIATION: (3635.1) or (8867.2) or (3636.1) or (27124.2) or (8867.1) or (27124.1) or (3633.1) or (56623.1) or (3632.1) SUBSYSTEM: Inositol phosphate metabolism EC Number: 3.1.3.56 Confidence Level: 4 AUTHORS: PMID:10593988,PMID:10764818,PMID:15261714,PMID:2906139,PMID:7721860,PMID:8006039,PMID:8013665,PMID:8530088,PMID:8769125,PMID:9428629,PMID:9824312 NOTES:NCD
reactant: MODEL1310110045#
is version of: http://identifiers.org/ec-code/3.1.3.56

metaR NDPK7n
type: Reaction
is version of: http://identifiers.org/ec-code/2.7.4.6
product: MODEL1310110045#
name: nucleoside-diphosphate kinase (ATP:dCDP), nuclear
fast: false
is: SBO:0000176
is described by: ECO:0000304
kinetic law: MODEL1310110045#
modifier: MODEL1310110045#
reactant: MODEL1310110045#
reversible: true
notes: GENE_ASSOCIATION: (4831.1 and 4830.1) or (4830.2 and 4831.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.6 Confidence Level: 4 AUTHORS: PMID:7050910 NOTES:Many nucleoside diphosphates (eight described) can act as acceptors. While many ribo- and deoxyribonucleoside triphosphates can act as donors, only ATP is chosen as a donor to minimize the number of total reactions.. Presence in the nucleus

http://identifiers.org/biomodels.db/MODEL1310110045#_3ead6c67_f0f2_43a8_9326_8f9c033c74bf
type: Species
has only substance units: false
is: SBO:0000252
boundary condition: true
initial amount: NaN
is encoded by: hsa:55967
is: F8VQS7
name: NDUFA12
constant: false
initial concentration: NaN

metaR RE1709C
is: SBO:0000176
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Tetrahydrobiopterin metabolism EC Number: 4.2.1.96 Confidence Level: 0 AUTHORS: PMID:10727395,PMID:8921004 NOTES:
reversible: true
is described by: ECO:0000000
kinetic law: MODEL1310110045#
reactant: MODEL1310110045#
fast: false
product: MODEL1310110045#
name: RE1709

metaR r1607
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reversible: true
type: Reaction
is described by: ECO:0000000
kinetic law: MODEL1310110045#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reactant: MODEL1310110045#
product: MODEL1310110045#
is: SBO:0000185

metaR r0456
name: ATP:deoxyguanosine 5-phosphotransferase Purine metabolism EC:2.7.1.113
type: Reaction
is version of: http://identifiers.org/ec-code/2.3.1.21
kinetic law: MODEL1310110045#
reactant: MODEL1310110045#
product: MODEL1310110045#
fast: false
is: SBO:0000176
reversible: false
modifier: MODEL1310110045#
notes: GENE_ASSOCIATION: (AA614647.1) or (1120.1) or (1374.1) or (1375.1) or (126129.1) or (1376.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.1.113 Confidence Level: 0 AUTHORS: PMID:15748706 NOTES:
is version of: http://identifiers.org/ec-code/2.7.1.32
is described by: ECO:0000000

metaM nad m
is: SBO:0000247
name: Nicotinamide adenine dinucleotide
has only substance units: false
constant: false
is: C00003
boundary condition: false
initial concentration: 1.0
is: http://identifiers.org/pubchem.compound/3305
type: Species
initial amount: NaN
is: HMDB00902
is: CHEBI:57540

metaR RE2666C
reactant: MODEL1310110045#
kinetic law: MODEL1310110045#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Glycosphingolipid metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:7930586 NOTES:
name: RE2666
type: Reaction
is described by: ECO:0000000
is: SBO:0000176
reversible: false
product: MODEL1310110045#

metaR EX 4abut LPAREN e RPAREN
kinetic law: MODEL1310110045#
reactant: MODEL1310110045#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 4-Aminobutanoate exchange
type: Reaction

metaR AG13T4g
kinetic law: MODEL1310110045#
type: Reaction
name: N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase, Golgi apparatus
is: SBO:0000176
is described by: ECO:0000000
product: MODEL1310110045#
modifier: MODEL1310110045#
reversible: false
is version of: http://identifiers.org/ec-code/2.4.1.149
fast: false
notes: GENE_ASSOCIATION: (11041.1) or (10678.1) or (93010.1) or (10331.1) or (374907.1) or (146712.1) or (374907.2) or (10678.2) or (79369.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.149 Confidence Level: 4 AUTHORS: PMID:10747980,PMID:11042166,PMID:12061784,PMID:12512857,PMID:15560372,PMID:15620693,PMID:9405606 NOTES:NCD
reactant: MODEL1310110045#

metaR RE2954C
is described by: ECO:0000000
reversible: true
modifier: MODEL1310110045#
type: Reaction
kinetic law: MODEL1310110045#
product: MODEL1310110045#
notes: GENE_ASSOCIATION: (5315.1) SUBSYSTEM: Pyrimidine synthesis EC Number: 2.7.1.40 Confidence Level: 0 AUTHORS: PMID:10585400,PMID:8967971 NOTES:
reactant: MODEL1310110045#
name: RE2954
is: SBO:0000176
fast: false
is version of: http://identifiers.org/ec-code/2.7.1.40

http://identifiers.org/biomodels.db/MODEL1310110045#_46830d49_4f3a_4e03_8ab1_c0155a4f7623
constant: false
type: Species
is: H0YMZ7
initial concentration: NaN
is: SBO:0000252
has only substance units: false
is encoded by: hsa:5151
initial amount: NaN
name: PDE8A
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110045#_c70e27c5_e077_484c_bf52_46017b7d5cab
is: Q8N142
boundary condition: true
is: SBO:0000252
has only substance units: false
constant: false
name: ADSSL1
initial amount: NaN
type: Species
is encoded by: hsa:122622
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110045#_4eeadac8_8c4b_484f_bc09_ef92f75df9f2
type: Species
is: E9PB82
is: SBO:0000252
constant: false
boundary condition: true
initial concentration: NaN
name: HSD17B4
has only substance units: false
initial amount: NaN
is encoded by: hsa:3295

metaR RE1573M
fast: false
type: Reaction
is version of: http://identifiers.org/ec-code/1.1.1.35
is version of: http://identifiers.org/ec-code/5.3.3.8
product: MODEL1310110045#
notes: GENE_ASSOCIATION: (1632.1) or (10455.1) or (1962.1) SUBSYSTEM: Fatty acid oxidation EC Number: 5.3.3.8 Confidence Level: 0 AUTHORS: PMID:10407780 NOTES:
kinetic law: MODEL1310110045#
name: RE1573
reactant: MODEL1310110045#
reversible: true
is: SBO:0000176
modifier: MODEL1310110045#
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110045#_b55eaea5_b5cc_4437_bc06_f45a448c129e
name: PDE7B
is encoded by: hsa:27115
initial amount: NaN
boundary condition: true
has only substance units: false
is: SBO:0000252
initial concentration: NaN
constant: false
is: Q9NP56
type: Species

metaR RE0577C
name: RE0577
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.1.2.2
reversible: true
is version of: http://identifiers.org/ec-code/2.3.1.65
modifier: MODEL1310110045#
kinetic law: MODEL1310110045#
product: MODEL1310110045#
reactant: MODEL1310110045#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (641372.1) or (641371.1) or (570.1) SUBSYSTEM: Fatty acid synthesis EC Number: 3.1.2.2 Confidence Level: 0 AUTHORS: PMID:10092594,PMID:10578051,PMID:16103133,PMID:16940157,PMID:9153233 NOTES:
fast: false
type: Reaction

metaM CE5121 m
is: CHEBI:57449
has only substance units: false
is: SBO:0000247
notes: FORMULA: C31H48N7O17P3S CHARGE: -4 INCHI: InChI=1/C31H52N7O17P3S/c1-4-5-6-7-8-9-10-11-22(40)59-15-14-33-21(39)12-13-34-29(43)26(42)31(2,3)17-52-58(49,50)55-57(47,48)51-16-20-25(54-56(44,45)46)24(41)30(53-20)38-19-37-23-27(32)35-18-36-28(23)38/h9-10,18-20,24-26,30,41-42H,4-8,11-17H2,1-3H3,(H,33,39)(H,34,43)(H,47,48)(H,49,50)(H2,32,35,36)(H2,44,45,46)/p-4/b10-9+/t20-,24+,25+,26u,30-/m0/s1 EHMN_ABBREVIATION: CE5121
initial amount: NaN
constant: false
name: trans-3-decenoyl-CoA
boundary condition: false
initial concentration: 1.0
type: Species

http://identifiers.org/biomodels.db/MODEL1310110045#_34aee548_2e4b_4dc8_89a7_7a591391d2dd
has only substance units: false
name: CPT2
constant: false
type: Species
boundary condition: true
initial amount: NaN
is encoded by: hsa:1376
is: SBO:0000252
is: P23786
initial concentration: NaN

metaR r1609
type: Reaction
is described by: ECO:0000000
reversible: true
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
fast: false
reactant: MODEL1310110045#
kinetic law: MODEL1310110045#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is: SBO:0000185
product: MODEL1310110045#

metaR r0668
modifier: MODEL1310110045#
is version of: http://identifiers.org/ec-code/2.4.2.19
reactant: MODEL1310110045#
notes: GENE_ASSOCIATION: (AI539321.1) or (23475.1) SUBSYSTEM: Unassigned EC Number: 2.7.7.43 Confidence Level: 0 AUTHORS: PMID:1577759,PMID:422125,PMID:4288894,PMID:4803836,PMID:9689047 NOTES:
is: SBO:0000176
name: CTP:N-acylneuraminate cytidylyltransferase Aminosugars metabolism EC:2.7.7.43
reversible: true
product: MODEL1310110045#
kinetic law: MODEL1310110045#
is described by: ECO:0000000
type: Reaction
fast: false

metaR r0309
product: MODEL1310110045#
notes: GENE_ASSOCIATION: (26.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.1.38 Confidence Level: 0 AUTHORS: PMID:12654921 NOTES:
type: Reaction
reactant: MODEL1310110045#
is: SBO:0000176
is described by: ECO:0000000
modifier: MODEL1310110045#
kinetic law: MODEL1310110045#
reversible: true
fast: false
is version of: http://identifiers.org/ec-code/1.4.3.22
name: trans-Hexadec-2-enoyl-CoA reductase Fatty acid elongation in mitochondria EC:1.3.1.38

metaM frdp x
type: Species
boundary condition: false
is: HMDB00961
notes: FORMULA: C15H25O7P2 CHARGE: -3 INCHI: InChI=1S/C15H28O7P2/c1-13(2)7-5-8-14(3)9-6-10-15(4)11-12-21-24(19,20)22-23(16,17)18/h7,9,11H,5-6,8,10,12H2,1-4H3,(H,19,20)(H2,16,17,18)/p-3/b14-9+,15-11+ HEPATONET_1.0_ABBREVIATION: HC00362 EHMN_ABBREVIATION: C00448
name: farnesyl pyrophosphate(3-)
is: SBO:0000247
is: CHEBI:175763
constant: false
initial concentration: 1.0
initial amount: NaN
has only substance units: false

metaM r5p r
type: Species
is: CHEBI:18189
has only substance units: false
is: HMDB00618
notes: FORMULA: C5H9O8P CHARGE: -2 INCHI: InChI=1S/C5H11O8P/c6-3-2(1-12-14(9,10)11)13-5(8)4(3)7/h2-8H,1H2,(H2,9,10,11)/t2-,3-,4-,5+/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00115 EHMN_ABBREVIATION: C00117
initial amount: NaN
name: alpha-D-Ribose 5-phosphate
boundary condition: false
constant: false
is: SBO:0000247
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110045#_d8fb8570_fb76_4622_b4f4_5923889a4feb
is encoded by: hsa:80724
has only substance units: false
is: G3XAJ0
is: SBO:0000252
initial amount: NaN
type: Species
name: ACAD10
initial concentration: NaN
constant: false
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110045#_1c3bf26f_1886_4d1a_b4e8_96406d33fb08
is: SBO:0000252
is encoded by: hsa:2639
type: Species
constant: false
boundary condition: true
has only substance units: false
initial amount: NaN
name: GCDH
initial concentration: NaN

metaR ARACHt
product: MODEL1310110045#
type: Reaction
name: fatty acid transport via diffusion
is described by: ECO:0000000
kinetic law: MODEL1310110045#
fast: false
reversible: true
reactant: MODEL1310110045#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11788354,PMID:12864740 NOTES:NJ

metaR LEUTA
product: MODEL1310110045#
fast: false
notes: GENE_ASSOCIATION: (586.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 2.6.1.6 Confidence Level: 4 AUTHORS: PMID:6933702,PMID:9165094 NOTES:_2.6.1.42
kinetic law: MODEL1310110045#
reversible: true
reactant: MODEL1310110045#
type: Reaction
is described by: ECO:0000269
is: SBO:0000176
name: leucine transaminase
modifier: MODEL1310110045#
is version of: http://identifiers.org/ec-code/2.6.1.42

metaM dcholcoa r
initial concentration: 1.0
is: CHEBI:28701
initial amount: NaN
is: HMDB06292
is: SBO:0000247
name: chenodeoxycholoyl coenzyme a
has only substance units: false
notes: FORMULA: C45H70N7O19P3S CHARGE: -4 INCHI: InChI=1S/C45H74N7O19P3S/c1-24(27-7-8-28-34-29(11-14-45(27,28)5)44(4)13-10-26(53)18-25(44)19-30(34)54)6-9-33(56)75-17-16-47-32(55)12-15-48-41(59)38(58)43(2,3)21-68-74(65,66)71-73(63,64)67-20-31-37(70-72(60,61)62)36(57)42(69-31)52-23-51-35-39(46)49-22-50-40(35)52/h22-31,34,36-38,42,53-54,57-58H,6-21H2,1-5H3,(H,47,55)(H,48,59)(H,63,64)(H,65,66)(H2,46,49,50)(H2,60,61,62)/t24-,25+,26-,27-,28+,29+,30-,31-,34+,36-,37-,38+,42-,44+,45-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01426 EHMN_ABBREVIATION: C05337
type: Species
constant: false
boundary condition: false

metaM thmpp c
constant: false
notes: FORMULA: C12H16N4O7P2S CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00071 EHMN_ABBREVIATION: C00068
has only substance units: false
boundary condition: false
is: CHEBI:45931
is: C00068
initial concentration: 1.0
type: Species
initial amount: NaN
is: SBO:0000247
name: Thiamine diphosphate
is: HMDB01372

metaR FAOXC122m
kinetic law: MODEL1310110045#
product: MODEL1310110045#
reactant: MODEL1310110045#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: isomerization(C12:2)m
type: Reaction

metaR FAOXC205C185m
kinetic law: MODEL1310110045#
product: MODEL1310110045#
reactant: MODEL1310110045#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C20:5-->C18:5)m
type: Reaction

metaR EX rib D LPAREN e RPAREN
kinetic law: MODEL1310110045#
reactant: MODEL1310110045#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for ribose
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110045#_f98a62a3_591b_494a_a800_0669c3033dfe
is: GO:0005794
is: SBO:0000290
constant: false
size: 1.0
spatial dimensions: 3.0
name: Golgi apparatus
type: Compartment

metaM lac D e
initial concentration: 1.0
is: HMDB01311
is: CHEBI:16004
type: Species
constant: false
boundary condition: false
has only substance units: false
is: SBO:0000247
initial amount: NaN
name: (R)-lactate
notes: FORMULA: C3H5O3 CHARGE: -1 INCHI: InChI=1S/C3H6O3/c1-2(4)3(5)6/h2,4H,1H3,(H,5,6)/p-1/t2-/m1/s1

metaR r2358
reversible: true
is: SBO:0000185
name: Organic anion transporter 5 Utilized transport
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
fast: false
type: Reaction
product: MODEL1310110045#
reactant: MODEL1310110045#
kinetic law: MODEL1310110045#
is described by: ECO:0000000

metaM dhcholestanate r
is: HMDB00359
has only substance units: false
is: CHEBI:16577
type: Species
is: SBO:0000247
boundary condition: false
constant: false
initial concentration: 1.0
notes: FORMULA: C27H45O4 CHARGE: -1 INCHI: InChI=1S/C27H46O4/c1-16(6-5-7-17(2)25(30)31)20-8-9-21-24-22(11-13-27(20,21)4)26(3)12-10-19(28)14-18(26)15-23(24)29/h16-24,28-29H,5-15H2,1-4H3,(H,30,31)/t16-,17?,18+,19-,20-,21+,22+,23-,24+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01313 EHMN_ABBREVIATION: C04554
initial amount: NaN
name: 3alpha,7alpha-Dihydroxy-5beta-cholestanate

metaR r1833
reversible: false
type: Reaction
modifier: MODEL1310110045#
name: Y+LAT2 Utilized transport
is: SBO:0000185
is described by: ECO:0000000
kinetic law: MODEL1310110045#
product: MODEL1310110045#
reactant: MODEL1310110045#
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
fast: false

http://identifiers.org/biomodels.db/MODEL1310110045#_196a919f_0f7d_4695_86f2_cce959810ddc
initial concentration: NaN
constant: false
has only substance units: false
initial amount: NaN
type: Species
is: SBO:0000252
name: PC
boundary condition: true
is encoded by: hsa:5091

metaR MANt1r
is described by: ECO:0000269
fast: false
reactant: MODEL1310110045#
is: SBO:0000185
reversible: true
modifier: MODEL1310110045#
product: MODEL1310110045#
name: mannose transport (uniport)
notes: GENE_ASSOCIATION: (6513.1) or (6515.1) or (6514.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:11882499,PMID:12135767,PMID:12750891,PMID:1701966,PMID:2182619,PMID:3103217,PMID:3399500,PMID:3839598,PMID:7926364,PMID:9770484 NOTES:NCD
kinetic law: MODEL1310110045#
type: Reaction

metaM frdp r
has only substance units: false
boundary condition: false
is: SBO:0000247
name: Farnesyl diphosphate
initial concentration: 1.0
is: CHEBI:175763
initial amount: NaN
is: HMDB00961
constant: false
is: C00448
notes: FORMULA: C15H25O7P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00362 EHMN_ABBREVIATION: C00448
type: Species

metaR EX no LPAREN e RPAREN
kinetic law: MODEL1310110045#
reactant: MODEL1310110045#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for NO
type: Reaction

metaM HC00900 c
is: SBO:0000247
constant: false
initial concentration: 1.0
type: Species
notes: FORMULA: C4H4O4 CHARGE: -2 INCHI: InChI=1S/C4H6O4/c1-2(3(5)6)4(7)8/h2H,1H3,(H,5,6)(H,7,8) EHMN_ABBREVIATION: C02170
boundary condition: false
is: CHEBI:30860
initial amount: NaN
has only substance units: false
name: Methylmalonate

http://identifiers.org/biomodels.db/MODEL1310110045#_0c11d393_84be_4641_9ecd_43d6d140dffc
is: P15291
is: SBO:0000252
type: Species
name: B4GALT1
initial concentration: NaN
has only substance units: false
initial amount: NaN
is encoded by: hsa:2683
boundary condition: true
constant: false

metaM ksi deg32 l
initial concentration: 1.0
type: Species
is: HMDB00143
has only substance units: false
boundary condition: false
is: CHEBI:12936
constant: false
notes: FORMULA: C82H135N5O67S2 CHARGE: -2
name: keratan sulfate I, degradation product 32
is: SBO:0000247
initial amount: NaN

metaR r2359
product: MODEL1310110045#
reactant: MODEL1310110045#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
kinetic law: MODEL1310110045#
type: Reaction
is: SBO:0000185
name: Organic anion transporter 5 Utilized transport
is described by: ECO:0000000
fast: false
reversible: true

metaR 5ADTSTSTERONEte
reversible: true
reactant: MODEL1310110045#
product: MODEL1310110045#
name: 5 alpha dihydrotesterone transport
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 1 AUTHORS: NOTES:specific mechanism not known, proton dependence for trans-mit transport has been suggested, however directionality and stoichiometry has not yet been elucidated. see PMID: 12770731 and others NJ
is: SBO:0000185
type: Reaction
kinetic law: MODEL1310110045#
fast: false
is described by: ECO:0000000

metaR r2356
type: Reaction
is described by: ECO:0000000
product: MODEL1310110045#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
reversible: true
kinetic law: MODEL1310110045#
name: Organic anion transporter 5 Utilized transport
fast: false
reactant: MODEL1310110045#

metaM h2o x
is: SBO:0000247
constant: false
notes: FORMULA: H2O CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00011 EHMN_ABBREVIATION: C00001
name: H2O
has only substance units: false
boundary condition: false
is: HMDB02111
initial concentration: 1.0
initial amount: NaN
is: C00001
type: Species
is: CHEBI:15377

http://identifiers.org/biomodels.db/MODEL1310110045#_b23e2e12_7224_4028_a0c1_e99954010e9b
is: A8K761
boundary condition: true
initial concentration: NaN
type: Species
initial amount: NaN
is encoded by: hsa:4716
constant: false
has only substance units: false
is: SBO:0000252
name: NDUFB10

metaM akg x
initial concentration: 1.0
is: HMDB00208
is: CHEBI:16810
has only substance units: false
is: SBO:0000247
constant: false
name: 2-oxoglutarate(2-)
type: Species
initial amount: NaN
notes: FORMULA: C5H4O5 CHARGE: -2 INCHI: InChI=1S/C5H6O5/c6-3(5(9)10)1-2-4(7)8/h1-2H2,(H,7,8)(H,9,10)/p-2 HEPATONET_1.0_ABBREVIATION: HC00035 EHMN_ABBREVIATION: C00026
boundary condition: false

metaR NAIt
product: MODEL1310110045#
name: Na+ / iodide cotransport
is described by: ECO:0000269
reactant: MODEL1310110045#
kinetic law: MODEL1310110045#
is: SBO:0000185
fast: false
notes: GENE_ASSOCIATION: (6528.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10893432,PMID:11034615,PMID:12679487,PMID:12748858,PMID:15546855,PMID:8559252,PMID:8806637,PMID:9341168 NOTES:NCD
type: Reaction
reversible: true
modifier: MODEL1310110045#

metaM lac D c
initial concentration: 1.0
is: CHEBI:16004
is: HMDB01311
type: Species
has only substance units: false
boundary condition: false
constant: false
name: (R)-lactate
notes: FORMULA: C3H5O3 CHARGE: -1 INCHI: InChI=1S/C3H6O3/c1-2(4)3(5)6/h2,4H,1H3,(H,5,6)/p-1/t2-/m1/s1
is: SBO:0000247
initial amount: NaN

metaM arachd e
has only substance units: false
notes: FORMULA: C20H31O2 CHARGE: -1 INCHI: InChI=1S/C20H32O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20(21)22/h6-7,9-10,12-13,15-16H,2-5,8,11,14,17-19H2,1H3,(H,21,22)/p-1/b7-6-,10-9-,13-12-,16-15-
type: Species
boundary condition: false
name: arachidonate
is: SBO:0000247
initial concentration: 1.0
is: HMDB01043
is: CHEBI:32395
initial amount: NaN
constant: false

http://identifiers.org/biomodels.db/MODEL1310110045#_d2ef21c2_fcf4_4769_a380_8c272c9aaa6e
is: Q8TE04
name: PANK1
type: Species
boundary condition: true
has only substance units: false
is: SBO:0000252
initial amount: NaN
constant: false
initial concentration: NaN
is encoded by: hsa:53354

metaR RE1804C
kinetic law: MODEL1310110045#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Bile acid synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:9660774 NOTES:
type: Reaction
fast: false
product: MODEL1310110045#
is: SBO:0000176
name: RE1804
reactant: MODEL1310110045#
reversible: true

metaR r1835
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
name: Y+LAT2 Utilized transport
type: Reaction
is: SBO:0000185
fast: false
is described by: ECO:0000000
product: MODEL1310110045#
reactant: MODEL1310110045#
reversible: false
kinetic law: MODEL1310110045#
modifier: MODEL1310110045#

metaR r2357
kinetic law: MODEL1310110045#
name: Organic anion transporter 5 Utilized transport
fast: false
reactant: MODEL1310110045#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
reversible: true
product: MODEL1310110045#
type: Reaction
is: SBO:0000185
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110045#_386d0aec_1326_4f79_99c8_d66a9f0f29b9
initial amount: NaN
is: P14618
name: PKM2
constant: false
has only substance units: false
type: Species
boundary condition: true
is encoded by: hsa:5315
is: SBO:0000252
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110045#_33f4d937_47c8_4dcd_8719_53d94dada456
is: SBO:0000252
initial concentration: NaN
constant: false
initial amount: NaN
boundary condition: true
type: Species
name: PC
is encoded by: hsa:5091
has only substance units: false
is: P11498

http://identifiers.org/biomodels.db/MODEL1310110045#_aaf87216_f96a_4d6c_b897_110fea4dba27
is: SBO:0000252
boundary condition: true
has only substance units: false
is: P40926
initial amount: NaN
constant: false
initial concentration: NaN
type: Species
name: MDH2
is encoded by: hsa:4191

metaR BALAtmr
fast: false
is described by: ECO:0000000
reactant: MODEL1310110045#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 1 AUTHORS: PMID:15304357 NOTES:SAB
product: MODEL1310110045#
reversible: true
is: SBO:0000185
name: Beta-alanine reversible mitochondrial transport (diffusion)
kinetic law: MODEL1310110045#
type: Reaction

metaM CE1939 e
notes: FORMULA: C7H18N2O CHARGE: 2 INCHI: InChI=1/C7H16N2O/c8-4-1-2-5-9-6-3-7-10/h7,9H,1-6,8H2/p+2 EHMN_ABBREVIATION: CE1939
type: Species
is: CHEBI:36781
initial amount: NaN
constant: false
has only substance units: false
name: spermidine monoaldehyde 1
initial concentration: 1.0
is: SBO:0000247
boundary condition: false

metaR UAG4E
reactant: MODEL1310110045#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/5.1.3.2
is described by: ECO:0000304
kinetic law: MODEL1310110045#
notes: GENE_ASSOCIATION: (2582.1) or (2582.2) SUBSYSTEM: Aminosugar metabolism EC Number: 5.1.3.7 Confidence Level: 2 AUTHORS: NOTES:NCD
modifier: MODEL1310110045#
product: MODEL1310110045#
fast: false
type: Reaction
name: UDP-N-acetylglucosamine 4-epimerase
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110045#_99c6c7b7_54a0_44b6_9975_85b18521846a
constant: false
is: B2RAT6
initial amount: NaN
is: SBO:0000252
has only substance units: false
initial concentration: NaN
name: GALT
boundary condition: true
type: Species
is encoded by: hsa:2592

http://identifiers.org/biomodels.db/MODEL1310110045#_c865caf4_11a7_4d20_beba_2cdee516196a
name: PRDX1
constant: false
is: Q06830
initial concentration: NaN
type: Species
is encoded by: hsa:5052
is: SBO:0000252
initial amount: NaN
boundary condition: true
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110045#_28249493_2241_435d_b371_595f6e00c99b
has only substance units: false
is encoded by: hsa:23417
type: Species
is: SBO:0000252
constant: false
initial concentration: NaN
is: O95822
initial amount: NaN
boundary condition: true
name: MLYCD

http://identifiers.org/biomodels.db/MODEL1310110045#_cd0f6983_5299_4364_928d_f8eabcb470ab
type: Species
initial amount: NaN
boundary condition: true
constant: false
is: SBO:0000252
initial concentration: NaN
name: _AA502753_1_m
is encoded by: hsa:AA502753
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110045#_bf7fc48e_5fa6_4919_a28a_c7dc2bd02ed0
initial concentration: NaN
is: Q9BZQ4
has only substance units: false
type: Species
is encoded by: hsa:23057
name: NMNAT2
constant: false
is: SBO:0000252
initial amount: NaN
boundary condition: true

metaR r2140
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.14
modifier: MODEL1310110045#
type: Reaction
kinetic law: MODEL1310110045#
reactant: MODEL1310110045#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
reversible: true
is: SBO:0000185
is described by: ECO:0000000
fast: false
product: MODEL1310110045#

http://identifiers.org/biomodels.db/MODEL1310110045#_36260ef8_7e63_435d_99aa_d14f2efac320
is: SBO:0000252
constant: false
initial concentration: NaN
name: ALDH3B2
has only substance units: false
type: Species
initial amount: NaN
is encoded by: hsa:222
boundary condition: true
is: P48448

http://identifiers.org/biomodels.db/MODEL1310110045#_6fdc682a_fffe_4594_8f8d_00d4cc0e61c5
constant: false
is encoded by: hsa:37
name: ACADVL
initial amount: NaN
is: SBO:0000252
initial concentration: NaN
type: Species
has only substance units: false
boundary condition: true
is: P49748

metaR HMGCOARc
fast: false
kinetic law: MODEL1310110045#
modifier: MODEL1310110045#
name: Hydroxymethylglutaryl CoA reductase (ir) in cytosol
notes: GENE_ASSOCIATION: (3156.1) SUBSYSTEM: Squalene and cholesterol synthesis EC Number: Confidence Level: 4 AUTHORS: Davidson, N. O., Magun, A. M. and Glickman, R. M. 2011. Enterocyte Lipid Absorption and Secretion. Comprehensive Physiology. 505?526, PMID: 17015489, PMID: 18216769, PMID: 6833883, PMID: 11229876. NOTES:Enterocytes stand next to liver in endogenous cholesterol synthesis. in rats they provide 25% of bodys cholesterol. the crypt epithelial cells synthesize maximum cholesterol when compared to other parts of the GI tract (PMCID: PMC292609). enzyme is located in E.R. but has catalytic site facing the cytosol (D.S. Sheriff (2004) Medical biochemistry, 1st edition Jaypee brothers Medical publishers pvt ltd page 502).
is: SBO:0000176
is described by: ECO:0000134
reversible: false
reactant: MODEL1310110045#
type: Reaction
product: MODEL1310110045#
is version of: http://identifiers.org/ec-code/1.1.1.34

metaR r2354
fast: false
is described by: ECO:0000000
product: MODEL1310110045#
is: SBO:0000185
name: Organic anion transporter 5 Utilized transport
reactant: MODEL1310110045#
reversible: true
kinetic law: MODEL1310110045#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
type: Reaction

metaM nad e
type: Species
boundary condition: false
initial concentration: 1.0
name: NAD(1-)
has only substance units: false
is: CHEBI:57540
constant: false
notes: FORMULA: C21H26N7O14P2 CHARGE: -1 INCHI: InChI=1S/C21H27N7O14P2/c22-17-12-19(25-7-24-17)28(8-26-12)21-16(32)14(30)11(41-21)6-39-44(36,37)42-43(34,35)38-5-10-13(29)15(31)20(40-10)27-3-1-2-9(4-27)18(23)33/h1-4,7-8,10-11,13-16,20-21,29-32H,5-6H2,(H5-,22,23,24,25,33,34,35,36,37)/p-1/t10-,11-,13-,14-,15-,16-,20-,21-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00013 EHMN_ABBREVIATION: C00003
is: SBO:0000247
initial amount: NaN
is: HMDB00902

http://identifiers.org/biomodels.db/MODEL1310110045#_80f75abd_da3b_4dcd_9fc2_e9e8e344860b
is: B3KTV4
has only substance units: false
constant: false
boundary condition: true
initial concentration: NaN
name: ADSSL1
is: SBO:0000252
is encoded by: hsa:122622
type: Species
initial amount: NaN

metaM ksi deg18 l
constant: false
notes: FORMULA: C146H235N10O127S7 CHARGE: -7
name: keratan sulfate I, degradation product 18
is: CHEBI:12936
type: Species
initial amount: NaN
boundary condition: false
is: HMDB00143
has only substance units: false
is: SBO:0000247
initial concentration: 1.0

metaR EX psyl LPAREN e RPAREN
kinetic law: MODEL1310110045#
reactant: MODEL1310110045#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for psyllium
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110045#_881b4ec6_97a6_4b68_b09d_86dfcef55cd7
constant: false
initial concentration: NaN
is encoded by: hsa:262
has only substance units: false
type: Species
name: AMD1
is: SBO:0000252
initial amount: NaN
is: P17707
boundary condition: true

metaR r0517
is described by: ECO:0000000
reactant: MODEL1310110045#
name: Succinyl-CoA:glycine C-succinyl-transferase(decarboxylating) EC:2.3.1.37
modifier: MODEL1310110045#
type: Reaction
notes: GENE_ASSOCIATION: (BE966236.1) or (6240.1) or (6241.1) or (50484.1) SUBSYSTEM: Unassigned EC Number: 2.3.1.37 Confidence Level: 0 AUTHORS: PMID:7592562 NOTES:
reversible: true
is version of: http://identifiers.org/ec-code/1.17.4.1
is: SBO:0000176
kinetic law: MODEL1310110045#
product: MODEL1310110045#
fast: false

metaR FTHFL
reversible: true
product: MODEL1310110045#
name: Formate-tetrahydrofolate ligase
is version of: http://identifiers.org/ec-code/1.5.1.5
kinetic law: MODEL1310110045#
notes: GENE_ASSOCIATION: (4522.1) or (286297.1) SUBSYSTEM: Folate metabolism EC Number: Confidence Level: 4 AUTHORS: NOTES:
modifier: MODEL1310110045#
fast: false
type: Reaction
is described by: ECO:0000134
is: SBO:0000176
reactant: MODEL1310110045#

metaR DOLP Lter
type: Reaction
name: dolichol phosphate flippase (liver)
is: SBO:0000176
reactant: MODEL1310110045#
product: MODEL1310110045#
kinetic law: MODEL1310110045#
reversible: false
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: N-glycan synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:12137737 NOTES:
is described by: ECO:0000000

metaR r2141
modifier: MODEL1310110045#
is described by: ECO:0000000
reactant: MODEL1310110045#
kinetic law: MODEL1310110045#
fast: false
is: SBO:0000185
type: Reaction
product: MODEL1310110045#
reversible: true
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.14
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:

metaR r2355
kinetic law: MODEL1310110045#
fast: false
product: MODEL1310110045#
reversible: true
is: SBO:0000185
name: Organic anion transporter 5 Utilized transport
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
reactant: MODEL1310110045#
type: Reaction
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110045#_7691198e_8cf3_4a16_977f_6cc92a0d8622
is encoded by: hsa:4830
is: SBO:0000252
initial concentration: NaN
has only substance units: false
boundary condition: true
name: NME1
is: P15531
type: Species
initial amount: NaN
constant: false

metaR GALt4
fast: false
modifier: MODEL1310110045#
is: SBO:0000185
reversible: true
name: galactose transport via sodium symport
kinetic law: MODEL1310110045#
type: Reaction
reactant: MODEL1310110045#
notes: GENE_ASSOCIATION: (200010.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12748858,PMID:15607332 NOTES:NCD
is described by: ECO:0000269
product: MODEL1310110045#

metaM dhcholestanate x
initial concentration: 1.0
is: SBO:0000247
has only substance units: false
name: 3alpha,7alpha-Dihydroxy-5beta-cholestanate
notes: FORMULA: C27H45O4 CHARGE: -1 INCHI: InChI=1S/C27H46O4/c1-16(6-5-7-17(2)25(30)31)20-8-9-21-24-22(11-13-27(20,21)4)26(3)12-10-19(28)14-18(26)15-23(24)29/h16-24,28-29H,5-15H2,1-4H3,(H,30,31)/t16-,17?,18+,19-,20-,21+,22+,23-,24+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01313 EHMN_ABBREVIATION: C04554
is: HMDB00359
type: Species
initial amount: NaN
is: CHEBI:16577
boundary condition: false
constant: false

metaR DOLPMT4 Ler
is: SBO:0000185
kinetic law: MODEL1310110045#
is described by: ECO:0000000
reversible: false
product: MODEL1310110045#
type: Reaction
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: N-glycan synthesis EC Number: 2.4.1.130 Confidence Level: 0 AUTHORS: NOTES:
name: dolichyl-phosphate-mannose-glycolipid alpha-mannosyltransferase (liver)
reactant: MODEL1310110045#

metaM gthox m
is: SBO:0000247
has only substance units: false
notes: FORMULA: C20H30N6O12S2 CHARGE: -2 INCHI: InChI=1S/C20H32N6O12S2/c21-9(19(35)36)1-3-13(27)25-11(17(33)23-5-15(29)30)7-39-40-8-12(18(34)24-6-16(31)32)26-14(28)4-2-10(22)20(37)38/h9-12H,1-8,21-22H2,(H,23,33)(H,24,34)(H,25,27)(H,26,28)(H,29,30)(H,31,32)(H,35,36)(H,37,38)/p-2/t9-,10-,11-,12-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00125 EHMN_ABBREVIATION: C00127
type: Species
boundary condition: false
is: HMDB03337
initial amount: NaN
constant: false
is: CHEBI:58297
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110045#_30e8b889_e4b7_4820_8f27_c14fecb442c2
initial amount: NaN
has only substance units: false
name: ACAT2
is: Q9BWD1
type: Species
initial concentration: NaN
is: SBO:0000252
constant: false
is encoded by: hsa:39
boundary condition: true

metaR r0514
reactant: MODEL1310110045#
is: SBO:0000176
reversible: false
kinetic law: MODEL1310110045#
notes: GENE_ASSOCIATION: (6576.1) SUBSYSTEM: Folate metabolism EC Number: 1.5.1.3 Confidence Level: 0 AUTHORS: PMID:15153070,PMID:16171773,PMID:1631094,PMID:4396284,PMID:6882460,PMID:962851 NOTES:
product: MODEL1310110045#
is described by: ECO:0000000
modifier: MODEL1310110045#
name: Dihydrofolate:NADP+ oxidoreductase One carbon pool by folate / Folate biosynthesis EC:1.5.1.3
fast: false
type: Reaction

metaM ddcacoa m
initial concentration: 1.0
constant: false
is: CHEBI:57375
is: HMDB03571
initial amount: NaN
type: Species
name: Dodecanoyl-CoA (n-C12:0CoA)
is: SBO:0000247
is: C01832
boundary condition: false
has only substance units: false
notes: FORMULA: C33H54N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00850 EHMN_ABBREVIATION: C01832

metaR DUTPDPn
type: Reaction
modifier: MODEL1310110045#
reversible: false
notes: GENE_ASSOCIATION: (1854.1) SUBSYSTEM: Nucleotide interconversion EC Number: 3.6.1.23 Confidence Level: 4 AUTHORS: PMID:12799180,PMID:8631816,PMID:9070952 NOTES:
is described by: ECO:0000269
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.6.1.23
name: dUTP diphosphatase, nuclear
kinetic law: MODEL1310110045#
reactant: MODEL1310110045#
product: MODEL1310110045#
fast: false

metaR r0728
fast: false
type: Reaction
is described by: ECO:0000000
kinetic law: MODEL1310110045#
name: (S)-Hydroxydecanoyl-CoA hydro-lyase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:4.2.1.17
product: MODEL1310110045#
is: SBO:0000176
reversible: true
reactant: MODEL1310110045#
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.17 Confidence Level: 0 AUTHORS: PMID:8012501,PMID:8188243 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110045#_3daa2bc9_c36c_49eb_8582_292192f14d76
has only substance units: false
name: NME1:NME2
boundary condition: true
constant: false
initial amount: NaN
is: SBO:0000297
type: Species
is encoded by: hsa:4830
initial concentration: NaN

metaR r2352
reversible: true
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
is described by: ECO:0000000
is: SBO:0000185
name: Organic anion transporter 5 Utilized transport
product: MODEL1310110045#
reactant: MODEL1310110045#
fast: false
kinetic law: MODEL1310110045#

metaR MTHFD
product: MODEL1310110045#
is version of: http://identifiers.org/ec-code/1.5.1.5
type: Reaction
is: SBO:0000176
is described by: ECO:0000134
reactant: MODEL1310110045#
notes: GENE_ASSOCIATION: (4522.1) SUBSYSTEM: Folate metabolism EC Number: 1.5.1.5 Confidence Level: 4 AUTHORS: PMID:2786332 NOTES:Human Y/N: Y
fast: false
name: methylenetetrahydrofolate dehydrogenase (NADP)
modifier: MODEL1310110045#
reversible: true
kinetic law: MODEL1310110045#

metaM nad c
initial amount: NaN
is: CHEBI:57540
initial concentration: 1.0
constant: false
is: http://identifiers.org/pubchem.compound/3305
boundary condition: false
is: C00003
is: SBO:0000247
is: HMDB00902
name: Nicotinamide adenine dinucleotide
type: Species
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110045#_ee559771_e604_4d43_a4dc_d1ecfdba7313
is: B3KNC1
initial amount: NaN
has only substance units: false
constant: false
initial concentration: NaN
boundary condition: true
name: UPB1
type: Species
is: SBO:0000252
is encoded by: hsa:51733

metaR r0660
is described by: ECO:0000000
fast: false
product: MODEL1310110045#
type: Reaction
is version of: http://identifiers.org/ec-code/1.5.1.2
kinetic law: MODEL1310110045#
notes: GENE_ASSOCIATION: (10637.1) or (5831.1) or (29920.1) or (65263.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.17 Confidence Level: 0 AUTHORS: PMID:8012501,PMID:8188243 NOTES:
name: (S)-3-Hydroxydodecanoyl-CoA hydro-lyase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:4.2.1.17
reversible: true
is: SBO:0000176
modifier: MODEL1310110045#
reactant: MODEL1310110045#

http://identifiers.org/biomodels.db/MODEL1310110045#_60696d41_24a0_45f9_b987_35c03a7884fb
type: Species
is: SBO:0000252
boundary condition: true
is encoded by: hsa:26266
name: SLC13A4
has only substance units: false
initial concentration: NaN
constant: false
initial amount: NaN
is: Q9UKG4

http://identifiers.org/biomodels.db/MODEL1310110045#_1295833d_6ba6_4d53_b729_a943ac08e41a
is: SBO:0000252
is encoded by: hsa:170712
initial amount: NaN
name: COX7B2
initial concentration: NaN
constant: false
is: Q8TF08
has only substance units: false
boundary condition: true
type: Species

metaM lnlc c
is: SBO:0000247
notes: FORMULA: C18H31O2 CHARGE: -1 INCHI: InChI=1S/C18H32O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20/h6-7,9-10H,2-5,8,11-17H2,1H3,(H,19,20)/p-1/b7-6-,10-9-
is: HMDB00673
initial amount: NaN
constant: false
boundary condition: false
initial concentration: 1.0
has only substance units: false
is: CHEBI:30245
type: Species
name: linoleate

metaR MTHFDm
product: MODEL1310110045#
name: methylenetetrahydrofolate dehydrogenase (NADP), mitochondrial
is: SBO:0000176
notes: GENE_ASSOCIATION: (25902.1) or (10797.1) SUBSYSTEM: Folate metabolism EC Number: 1.5.1.5 Confidence Level: 4 AUTHORS: PMID:12937168,PMID:8218174 NOTES:NCD
reactant: MODEL1310110045#
modifier: MODEL1310110045#
fast: false
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/6.3.4.3
reversible: true
type: Reaction
kinetic law: MODEL1310110045#
is version of: http://identifiers.org/ec-code/3.5.4.9

http://identifiers.org/biomodels.db/MODEL1310110045#_4c8b32c1_5fc1_4a0a_a0ff_a4a7df64348c
is encoded by: hsa:2645
initial concentration: NaN
initial amount: NaN
constant: false
boundary condition: true
is: Q53Y25
type: Species
has only substance units: false
is: SBO:0000252
name: GCK

metaM etfox m
constant: false
is: CHEBI:57312
initial amount: NaN
is: SBO:0000247
has only substance units: false
name: Electron transfer flavoprotein oxidized
boundary condition: false
notes: FORMULA: R CHARGE: 0
initial concentration: 1.0
is: HMDB01356
type: Species

metaR LPCOXp
is version of: http://identifiers.org/ec-code/1.5.3.1
name: L-pipecolate oxidase, peroxisomal
is: SBO:0000176
reactant: MODEL1310110045#
type: Reaction
is described by: ECO:0000269
kinetic law: MODEL1310110045#
reversible: false
product: MODEL1310110045#
modifier: MODEL1310110045#
notes: GENE_ASSOCIATION: (51268.1) SUBSYSTEM: Lysine metabolism EC Number: 1.5.3.7 Confidence Level: 4 AUTHORS: PMID:10772957 NOTES:
fast: false

metaR ENGASEly
fast: false
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: N-glycan degradation EC Number: 3.2.1.96 Confidence Level: 0 AUTHORS: NOTES:NCD
reactant: MODEL1310110045#
type: Reaction
product: MODEL1310110045#
name: endo-beta-N-acetylglucosaminidase, lysosomal
is described by: ECO:0000000
reversible: false
kinetic law: MODEL1310110045#

http://identifiers.org/biomodels.db/MODEL1310110045#_fa94890a_2428_497c_8ee1_011409bc21d6
has only substance units: false
initial concentration: NaN
boundary condition: true
constant: false
is: P11586
is: SBO:0000252
name: MTHFD1
is encoded by: hsa:4522
type: Species
initial amount: NaN

metaR EX pro L LPAREN e RPAREN
kinetic law: MODEL1310110045#
reactant: MODEL1310110045#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: L-Proline exchange
type: Reaction

metaM ksi deg3 l
type: Species
notes: FORMULA: C233H371N16O205S12 CHARGE: -13
initial concentration: 1.0
is: SBO:0000247
initial amount: NaN
constant: false
is: CHEBI:57312
name: keratan sulfate I, degradation product 3
has only substance units: false
is: HMDB01356
boundary condition: false

metaR FAOXC103C102m
kinetic law: MODEL1310110045#
product: MODEL1310110045#
reactant: MODEL1310110045#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C10:3-->C10:2)m
type: Reaction

metaR r2353
is: SBO:0000185
name: Organic anion transporter 5 Utilized transport
product: MODEL1310110045#
type: Reaction
reactant: MODEL1310110045#
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
fast: false
kinetic law: MODEL1310110045#
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110045#_37287419_0a54_4d71_91bb_93964d7e7001
is: SBO:0000252
is: Q13423
type: Species
is encoded by: hsa:23530
has only substance units: false
initial amount: NaN
initial concentration: NaN
boundary condition: true
constant: false
name: NNT

metaM pail34p hs c
name: 1-phosphatidyl-1D-myo-inositol 3,4-bisphosphate(5-)
constant: false
notes: FORMULA: C9H14O15P3FULLRCO2FULLR2CO2 CHARGE: -5
initial concentration: 1.0
boundary condition: false
is: SBO:0000247
has only substance units: false
initial amount: NaN
is: CHEBI:57658
type: Species

metaR MTHFD2m
kinetic law: MODEL1310110045#
reversible: true
is described by: ECO:0000254
reactant: MODEL1310110045#
is: SBO:0000176
type: Reaction
modifier: MODEL1310110045#
name: methylenetetrahydrofolate dehydrogenase (NAD), mitochondrial
product: MODEL1310110045#
notes: GENE_ASSOCIATION: (10797.1) SUBSYSTEM: Folate metabolism EC Number: 1.5.1.5 Confidence Level: 2 AUTHORS: PMID:8218174 NOTES:NCD
fast: false
is version of: http://identifiers.org/ec-code/3.5.4.9

metaR ACETONEt2
product: MODEL1310110045#
is described by: ECO:0000269
modifier: MODEL1310110045#
name: acetone transport via proton symport
notes: GENE_ASSOCIATION: (6566.1) or (9123.1) or (9194.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10510291,PMID:11101640,PMID:12739169,PMID:7835905,PMID:8476015,PMID:9425115,PMID:9508842,PMID:9649795,PMID:9786900,PMID:9824713 NOTES:NCD
reactant: MODEL1310110045#
fast: false
is: SBO:0000185
kinetic law: MODEL1310110045#
type: Reaction
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110045#_d3437674_b910_4641_9b76_9245e80e8912
initial concentration: NaN
has only substance units: false
name: _D29675_1_e
is encoded by: hsa:D29675
is: SBO:0000252
type: Species
constant: false
initial amount: NaN
boundary condition: true

metaR MTHFC
name: methenyltetrahydrofolate cyclohydrolase
is version of: http://identifiers.org/ec-code/3.5.4.9
reversible: true
is described by: ECO:0000134
modifier: MODEL1310110045#
type: Reaction
fast: false
is version of: http://identifiers.org/ec-code/1.5.1.5
is: SBO:0000176
notes: GENE_ASSOCIATION: (4522.1) or (100287639.1) or (441024.1) SUBSYSTEM: Folate metabolism EC Number: 3.5.4.9 Confidence Level: 4 AUTHORS: PMID:2786332 NOTES:Human Y/N: Y
product: MODEL1310110045#
kinetic law: MODEL1310110045#
reactant: MODEL1310110045#

metaR G6PDH2rer
type: Reaction
product: MODEL1310110045#
modifier: MODEL1310110045#
is version of: http://identifiers.org/ec-code/1.1.1.47
reactant: MODEL1310110045#
is: SBO:0000176
reversible: true
is described by: ECO:0000269
fast: false
name: glucose 6-phosphate dehydrogenase, endoplasmic reticulum
kinetic law: MODEL1310110045#
notes: GENE_ASSOCIATION: (9563.1) SUBSYSTEM: Pentose phosphate pathway EC Number: 1.1.1.47 Confidence Level: 4 AUTHORS: PMID:10349511,PMID:12831846,PMID:2156506 NOTES:NCD

http://identifiers.org/biomodels.db/MODEL1310110045#_6431be91_219c_4ee0_8977_2ec1c5409936
initial concentration: NaN
type: Species
constant: false
boundary condition: true
has only substance units: false
is encoded by: hsa:3636
is: O15357
is: SBO:0000252
initial amount: NaN
name: INPPL1

http://identifiers.org/biomodels.db/MODEL1310110045#_b4786d6e_15c1_4146_b4fe_947a73992dc1
name: DDO
has only substance units: false
constant: false
is encoded by: hsa:8528
initial concentration: NaN
is: SBO:0000252
initial amount: NaN
type: Species
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110045#_27951bba_1f70_45dd_b32a_1e43ccf52e7e
is: Q9Y227
has only substance units: false
constant: false
is: SBO:0000252
boundary condition: true
type: Species
initial concentration: NaN
name: ENTPD4
initial amount: NaN
is encoded by: hsa:9583

metaR DOLMANP Lter
reversible: false
reactant: MODEL1310110045#
notes: GENE_ASSOCIATION: SUBSYSTEM: N-glycan synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:12137737 NOTES:
name: dolichol-phosphate mannose flippase (liver)
is described by: ECO:0000000
kinetic law: MODEL1310110045#
type: Reaction
product: MODEL1310110045#
fast: false
is: SBO:0000185

metaR r0726
notes: GENE_ASSOCIATION: (AI924226.1) or (53354.1) or (80025.1) or (79646.1) or (55229.1) or (100128062.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.1.1.35 Confidence Level: 0 AUTHORS: PMID:10231530,PMID:10329704,PMID:1550553,PMID:1651711,PMID:7150615,PMID:8188243,PMID:8687463,PMID:9553139 NOTES:
name: (S)-Hydroxydecanoyl-CoA:NAD+ oxidoreductase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:1.1.1.35 EC:1.1.1.211
type: Reaction
modifier: MODEL1310110045#
is described by: ECO:0000000
kinetic law: MODEL1310110045#
is: SBO:0000176
fast: false
reactant: MODEL1310110045#
product: MODEL1310110045#
is version of: http://identifiers.org/ec-code/2.7.1.33
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110045#_b4ab0932_01a1_46e0_9bdc_e6e3c3ae8963
is: SBO:0000252
name: PGM2
is encoded by: hsa:55276
is: Q96G03
has only substance units: false
type: Species
boundary condition: true
constant: false
initial amount: NaN
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110045#_843c5814_e318_4be9_b2a4_0e4b804e786a
type: Species
boundary condition: true
initial concentration: NaN
constant: false
initial amount: NaN
has only substance units: false
is: SBO:0000252
is: Q9H6Y6
name: MYO5B
is encoded by: hsa:4645

metaR r0512
reactant: MODEL1310110045#
modifier: MODEL1310110045#
is: SBO:0000176
notes: GENE_ASSOCIATION: (BE966236.1) or (6240.1) or (6241.1) or (50484.1) SUBSYSTEM: Folate metabolism EC Number: 1.5.1.3 Confidence Level: 0 AUTHORS: PMID:15153070,PMID:1631094,PMID:6882460 NOTES:
reversible: true
name: Dihydrofolate:NAD+ oxidoreductase Folate biosynthesis EC:1.5.1.3
is version of: http://identifiers.org/ec-code/1.17.4.1
fast: false
kinetic law: MODEL1310110045#
is described by: ECO:0000000
product: MODEL1310110045#
type: Reaction

metaM HC02179 e
constant: false
boundary condition: false
notes: FORMULA: C20H31O3 CHARGE: -1 INCHI: InChI=1S/C20H32O3/c21-19-17-15-13-11-9-7-5-3-1-2-4-6-8-10-12-14-16-18-20(22)23/h1,3-4,6-7,9-10,12,21H,2,5,8,11,13-19H2,(H,22,23)/b3-1-,6-4-,9-7-,12-10- EHMN_ABBREVIATION: C14748
name: 20-hydroxy-arachidonate
initial amount: NaN
is: CHEBI:34306
type: Species
initial concentration: 1.0
is: SBO:0000247
has only substance units: false

metaM lnlc e
initial concentration: 1.0
is: HMDB00673
initial amount: NaN
name: linoleate
boundary condition: false
has only substance units: false
notes: FORMULA: C18H31O2 CHARGE: -1 INCHI: InChI=1S/C18H32O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20/h6-7,9-10H,2-5,8,11-17H2,1H3,(H,19,20)/p-1/b7-6-,10-9-
is: CHEBI:30245
is: SBO:0000247
constant: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110045#_445340df_babb_4850_bd30_346fcceea988
is: SBO:0000252
is encoded by: hsa:9514
boundary condition: true
initial concentration: NaN
has only substance units: false
initial amount: NaN
name: GAL3ST1
constant: false
is: Q99999
type: Species

http://identifiers.org/biomodels.db/MODEL1310110045#_ed60bd0c_506d_45b6_97ab_ba6547c7a5b1
is: SBO:0000252
is: P50226
has only substance units: false
type: Species
initial concentration: NaN
is encoded by: hsa:6799
name: SULT1A2
initial amount: NaN
constant: false
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110045#_a19c699d_2cb7_4bea_a099_2e34cfde6950
name: _AV717590_1_m
initial amount: NaN
constant: false
has only substance units: false
is encoded by: hsa:AV717590
type: Species
is: SBO:0000252
boundary condition: true
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110045#_4da5340f_9361_4ff1_b8bf_6e71d467696c
initial concentration: NaN
type: Species
has only substance units: false
is: SBO:0000252
is: P37837
constant: false
is encoded by: hsa:6888
boundary condition: true
initial amount: NaN
name: TALDO1

metaR ASCBOX
product: MODEL1310110045#
fast: false
type: Reaction
reactant: MODEL1310110045#
is: SBO:0000176
reversible: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Vitamin C metabolism EC Number: Confidence Level: 2 AUTHORS: NOTES:NCD
is described by: ECO:0000000
kinetic law: MODEL1310110045#
name: ascorbic acid oxidase

metaR r0666
reversible: true
name: 2-(Formamido)-N1-(5-phosphoribosyl)acetamidine cyclo-ligase (ADP-forming) Purine metabolism EC:6.3.3.1
is version of: http://identifiers.org/ec-code/1.2.4.2
is: SBO:0000176
fast: false
modifier: MODEL1310110045#
notes: GENE_ASSOCIATION: (4967.1) or (55753.1) SUBSYSTEM: Purine synthesis EC Number: 6.3.3.1 Confidence Level: 0 AUTHORS: PMID:4084560 NOTES:
reactant: MODEL1310110045#
is described by: ECO:0000000
type: Reaction
kinetic law: MODEL1310110045#
product: MODEL1310110045#

metaR ASCBt4
notes: GENE_ASSOCIATION: (9962.2) or (9963.1) or (9962.1) or (9963.2) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10471399,PMID:10556483,PMID:10556521,PMID:10631088,PMID:15705056 NOTES:NCD
kinetic law: MODEL1310110045#
type: Reaction
name: L-ascorbate transport via proton symport
is described by: ECO:0000269
reversible: true
reactant: MODEL1310110045#
product: MODEL1310110045#
modifier: MODEL1310110045#
fast: false
is: SBO:0000185

metaR EX nad LPAREN e RPAREN
kinetic law: MODEL1310110045#
reactant: MODEL1310110045#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Nicotinamide adenine dinucleotide exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110045#_0ff4f96c_d2f5_4e09_b001_dbf151b5bdc4
initial amount: NaN
initial concentration: NaN
constant: false
has only substance units: false
type: Species
is: SBO:0000252
is encoded by: hsa:8818
name: DPM2
boundary condition: true

metaM HC02179 c
has only substance units: false
type: Species
notes: FORMULA: C20H31O3 CHARGE: -1 INCHI: InChI=1S/C20H32O3/c21-19-17-15-13-11-9-7-5-3-1-2-4-6-8-10-12-14-16-18-20(22)23/h1,3-4,6-7,9-10,12,21H,2,5,8,11,13-19H2,(H,22,23)/b3-1-,6-4-,9-7-,12-10- EHMN_ABBREVIATION: C14748
initial concentration: 1.0
is: CHEBI:34306
initial amount: NaN
is: SBO:0000247
name: 20-hydroxy-arachidonate
boundary condition: false
constant: false

metaR NACHEXA16ly
modifier: MODEL1310110045#
type: Reaction
kinetic law: MODEL1310110045#
reactant: MODEL1310110045#
product: MODEL1310110045#
name: beta-N-acetylhexosaminidase A, lysosomal
is version of: http://identifiers.org/ec-code/3.2.1.52
notes: GENE_ASSOCIATION: (3073.1) or (3073.1 and 3074.1) SUBSYSTEM: Keratan sulfate degradation EC Number: Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12706724,PMID:8993162 NOTES:Note that this reaction is specific to beta-N-acetylhexosaminidase A and cannot be catalyzed by beta-N-acetylhexosaminidase B (or presumably beta-N-acetylhexosaminidase S). This is also a lumped reaction, representing the cleavage of GalNAc4S or GalNAc6S and N-acetylgalactosamine 4-sulfatase or 6-sulfatase. NCD
is: SBO:0000176
is described by: ECO:0000000
reversible: false
fast: false

metaM biocyt m
is: http://identifiers.org/pubchem.compound/7886
boundary condition: false
initial concentration: 1.0
notes: FORMULA: C16H28N4O4S CHARGE: 0 INCHI: InChI=1/C16H28N4O4S/c17-10(15(22)23)5-3-4-8-18-13(21)7-2-1-6-12-14-11(9-25-12)19-16(24)20-14/h10-12,14H,1-9,17H2,(H,18,21)(H,22,23)(H2,19,20,24)/t10-,11-,12-,14-/m0/s1 EHMN_ABBREVIATION: C05552
initial amount: NaN
constant: false
is: HMDB03134
is: SBO:0000247
is: C05552
name: Biocytin
type: Species
has only substance units: false

metaR BTNtn
is described by: ECO:0000000
reversible: true
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: PMID:16011464,PMID:5867120,PMID:7758201,PMID:8593541 NOTES:IT
kinetic law: MODEL1310110045#
product: MODEL1310110045#
is: SBO:0000185
reactant: MODEL1310110045#
name: Biotin transport, nuclear
type: Reaction

metaR FAOXC161802m
reversible: false
notes: GENE_ASSOCIATION: (34.1) or (35.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.74 Confidence Level: 4 AUTHORS: NOTES:_4 rounds of beta ox, 1 loss of degree of unsat -> only 3 fad oxidized c16:1 -> c8:0 4 step FAO lumped for 2 rounds also includes EC 1.1.1.35, 1.1.1.211, 1.3.3.6, 4.2.1.17, 4.2.1.74 NJ
reactant: MODEL1310110045#
name: Beta oxidation fatty acid
modifier: MODEL1310110045#
type: Reaction
is version of: http://identifiers.org/ec-code/1.3.8.1
is version of: http://identifiers.org/ec-code/1.3.99.3
fast: false
is described by: ECO:0000269
kinetic law: MODEL1310110045#
is: SBO:0000176
product: MODEL1310110045#

metaR PYK
name: pyruvate kinase
product: MODEL1310110045#
fast: false
notes: GENE_ASSOCIATION: (5315.2) or (5313.2) or (5315.3) or (5313.1) or (113452.1) or (5315.1) SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: Confidence Level: 0 AUTHORS: NOTES:
is: SBO:0000176
is described by: ECO:0000134
modifier: MODEL1310110045#
reversible: false
type: Reaction
kinetic law: MODEL1310110045#
is version of: http://identifiers.org/ec-code/2.7.1.40
reactant: MODEL1310110045#

metaR r0724
modifier: MODEL1310110045#
kinetic law: MODEL1310110045#
type: Reaction
is described by: ECO:0000000
name: Decanoyl-CoA:acetyl-CoA C-acyltransferase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:2.3.1.16
fast: false
is version of: http://identifiers.org/ec-code/2.7.1.33
product: MODEL1310110045#
is: SBO:0000176
reactant: MODEL1310110045#
notes: GENE_ASSOCIATION: (AI924226.1) or (53354.1) or (80025.1) or (79646.1) or (55229.1) or (100128062.1) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.16 Confidence Level: 0 AUTHORS: PMID:1121274,PMID:1679347,PMID:3194209,PMID:6378901,PMID:8241273 NOTES:
reversible: true

metaR RE1709N
is version of: http://identifiers.org/ec-code/4.2.1.96
fast: false
reversible: true
product: MODEL1310110045#
is: SBO:0000176
reactant: MODEL1310110045#
notes: GENE_ASSOCIATION: (5092.1) or (84105.1) SUBSYSTEM: Tetrahydrobiopterin metabolism EC Number: 4.2.1.96 Confidence Level: 0 AUTHORS: PMID:10727395,PMID:8921004 NOTES:
type: Reaction
is described by: ECO:0000000
kinetic law: MODEL1310110045#
name: RE1709
modifier: MODEL1310110045#

metaM docohexcoa m
type: Species
is: SBO:0000247
notes: FORMULA: C43H62N7O17P3S CHARGE: -4
initial amount: NaN
name: 2,4,7,10,13,16-docosahexenoylcoa
is: HMDB06294
has only substance units: false
constant: false
initial concentration: 1.0
boundary condition: false

metaM nadp x
initial concentration: 1.0
boundary condition: false
name: Nicotinamide adenine dinucleotide phosphate
initial amount: NaN
type: Species
notes: FORMULA: C21H25N7O17P3 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00016 EHMN_ABBREVIATION: C00006
constant: false
is: HMDB00217
is: SBO:0000247
has only substance units: false
is: CHEBI:58349
is: C00006

metaM biocyt n
initial concentration: 1.0
is: http://identifiers.org/pubchem.compound/7886
is: HMDB03134
has only substance units: false
initial amount: NaN
constant: false
name: Biocytin
notes: FORMULA: C16H28N4O4S CHARGE: 0 INCHI: InChI=1/C16H28N4O4S/c17-10(15(22)23)5-3-4-8-18-13(21)7-2-1-6-12-14-11(9-25-12)19-16(24)20-14/h10-12,14H,1-9,17H2,(H,18,21)(H,22,23)(H2,19,20,24)/t10-,11-,12-,14-/m0/s1 EHMN_ABBREVIATION: C05552
is: SBO:0000247
is: C05552
type: Species
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110045#_28764816_3343_4e02_bacb_ce9bbbb58b8a
initial concentration: NaN
is: Q9UI40
type: Species
initial amount: NaN
constant: false
boundary condition: true
is encoded by: hsa:25769
name: SLC24A2
has only substance units: false
is: SBO:0000252

metaR HSD17B4x
notes: GENE_ASSOCIATION: (3295.1) SUBSYSTEM: Bile acid synthesis EC Number: Confidence Level: 4 AUTHORS: NOTES:see Russell bile acid synthesis review paper in human recon citation db adamanski et al Steroids (1997) 62:159 notes cofactor NADP/NADPH use
type: Reaction
reactant: MODEL1310110045#
is: SBO:0000176
product: MODEL1310110045#
reversible: false
name: hydroxysteroid (17-beta) dehydrogenase 4
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/4.2.1.107
modifier: MODEL1310110045#
fast: false
kinetic law: MODEL1310110045#

http://identifiers.org/biomodels.db/MODEL1310110045#_12f6723d_6c4d_4b6c_af9a_53d709d83800
initial concentration: NaN
initial amount: NaN
is: SBO:0000252
boundary condition: true
constant: false
name: _BG035985_1_c
has only substance units: false
is encoded by: hsa:BG035985
type: Species

metaR GUAt
modifier: MODEL1310110045#
reactant: MODEL1310110045#
product: MODEL1310110045#
is described by: ECO:0000269
fast: false
reversible: true
kinetic law: MODEL1310110045#
type: Reaction
is: SBO:0000185
notes: GENE_ASSOCIATION: (3177.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12006583,PMID:12838422 NOTES:JLR
name: Guanine transport

metaR EX mag hs LPAREN e RPAREN
kinetic law: MODEL1310110045#
reactant: MODEL1310110045#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Monoacylglycerol 2 (homo sapiens) exchange
type: Reaction

metaR RE0944E
product: MODEL1310110045#
reactant: MODEL1310110045#
fast: false
kinetic law: MODEL1310110045#
is described by: ECO:0000000
name: RE0944
is version of: http://identifiers.org/ec-code/3.2.1.17
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.2.1.1
reversible: true
type: Reaction
notes: GENE_ASSOCIATION: (276.1) or (277.1) or (278.1) or (279.1) or (276.1) or (277.1) or (278.1) or (279.1) or (280.1) or (84569.1) SUBSYSTEM: Starch and sucrose metabolism EC Number: 3.2.1.1 Confidence Level: 0 AUTHORS: PMID:385176,PMID:8528071,PMID:890964 NOTES:
modifier: MODEL1310110045#

metaR PCHOL HSter
fast: false
kinetic law: MODEL1310110045#
reversible: true
type: Reaction
is: SBO:0000185
product: MODEL1310110045#
name: phosphatidylcholine scramblase
reactant: MODEL1310110045#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: PMID:10856717 NOTES:
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110045#_33b7bec2_456b_4c4c_a5e4_962fd7c09691
is: Q15181
is: SBO:0000252
initial concentration: NaN
constant: false
has only substance units: false
name: PPA1
is encoded by: hsa:5464
type: Species
boundary condition: true
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110045#_bc3b74c6_7250_4464_bc0d_ebe530bd3184
has only substance units: false
initial concentration: NaN
constant: false
is encoded by: hsa:343
initial amount: NaN
boundary condition: true
is: O94778
is: SBO:0000252
type: Species
name: AQP8

metaR EX ade LPAREN e RPAREN
kinetic law: MODEL1310110045#
reactant: MODEL1310110045#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Adenine exchange
type: Reaction

metaR VLCS2r
product: MODEL1310110045#
notes: GENE_ASSOCIATION: (11001.1) SUBSYSTEM: Bile acid synthesis EC Number: 6.2.1.7 Confidence Level: 2 AUTHORS: NOTES:from uniprot and lit - see human recon lit refs divalent cation requirement - unclear which one, reaction inhibited in the presence of EDTA (may just be MgATP or MgATP) - see Kelley and Vessey Biochimica et Biophysica Acta (1994) 1209: 51-55 temporarily will have H+ balance reaction NJ
reactant: MODEL1310110045#
is: SBO:0000176
name: Very-long-chain-fatty-acid-CoA ligase
modifier: MODEL1310110045#
type: Reaction
reversible: false
fast: false
is described by: ECO:0000304
is version of: http://identifiers.org/ec-code/6.2.1.3
kinetic law: MODEL1310110045#

metaM dcholcoa c
name: chenodeoxycholoyl coenzyme a
is: HMDB06292
is: SBO:0000247
notes: FORMULA: C45H70N7O19P3S CHARGE: -4 INCHI: InChI=1S/C45H74N7O19P3S/c1-24(27-7-8-28-34-29(11-14-45(27,28)5)44(4)13-10-26(53)18-25(44)19-30(34)54)6-9-33(56)75-17-16-47-32(55)12-15-48-41(59)38(58)43(2,3)21-68-74(65,66)71-73(63,64)67-20-31-37(70-72(60,61)62)36(57)42(69-31)52-23-51-35-39(46)49-22-50-40(35)52/h22-31,34,36-38,42,53-54,57-58H,6-21H2,1-5H3,(H,47,55)(H,48,59)(H,63,64)(H,65,66)(H2,46,49,50)(H2,60,61,62)/t24-,25+,26-,27-,28+,29+,30-,31-,34+,36-,37-,38+,42-,44+,45-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01426 EHMN_ABBREVIATION: C05337
is: CHEBI:28701
constant: false
type: Species
initial amount: NaN
has only substance units: false
boundary condition: false
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110045#_37892580_2800_4cc9_87ee_76e8770bddb6
type: Species
is: SBO:0000252
is encoded by: hsa:34
boundary condition: true
initial concentration: NaN
name: ACADM
initial amount: NaN
has only substance units: false
constant: false
is: P11310

metaM mal L x
type: Species
has only substance units: false
name: (S)-malate(2-)
notes: FORMULA: C4H4O5 CHARGE: -2 INCHI: InChI=1S/C4H6O5/c5-2(4(8)9)1-3(6)7/h2,5H,1H2,(H,6,7)(H,8,9)/p-2/t2-/m0/s1
is: SBO:0000247
boundary condition: false
initial amount: NaN
initial concentration: 1.0
constant: false
is: HMDB00156

http://identifiers.org/biomodels.db/MODEL1310110045#_c1688d7a_d8ef_4928_a810_a29a93e890dc
is: Q9UKM7
type: Species
name: MAN1B1
constant: false
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:11253
is: SBO:0000252
boundary condition: true
has only substance units: false

metaM cys L c
initial concentration: 1.0
is: HMDB00574
notes: FORMULA: C3H7NO2S CHARGE: 0 INCHI: InChI=1S/C3H7NO2S/c4-2(1-7)3(5)6/h2,7H,1,4H2,(H,5,6)/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00099
constant: false
type: Species
initial amount: NaN
boundary condition: false
is: CHEBI:17561
is: SBO:0000247
name: L-cysteine
has only substance units: false

metaR r0735
kinetic law: MODEL1310110045#
product: MODEL1310110045#
fast: false
reversible: true
name: trans-Dec-2-enoyl-CoA reductase Fatty acid elongation in mitochondria EC:1.3.1.38
is described by: ECO:0000000
type: Reaction
notes: GENE_ASSOCIATION: (AA081045.1) or (AI620219.1) or (219.1) or (217.1) or (224.1) or (501.1) or (223.1) or (AU149534.1) or (T83654.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.1.38 Confidence Level: 0 AUTHORS: PMID:12654921 NOTES:
modifier: MODEL1310110045#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.2.1.3
reactant: MODEL1310110045#

metaM gthox c
notes: FORMULA: C20H30N6O12S2 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00125 EHMN_ABBREVIATION: C00127
boundary condition: false
name: Oxidized glutathione
is: HMDB03337
is: CHEBI:58297
initial concentration: 1.0
is: SBO:0000247
has only substance units: false
is: C00127
constant: false
initial amount: NaN
type: Species

metaM CE2417 m
type: Species
has only substance units: false
name: 3(S)-hydroxy-5Z,8Z-tetradecadienoyl-CoA
constant: false
is: HMDB11123
notes: FORMULA: C35H54N7O18P3S CHARGE: -4 INCHI: InChI=1/C35H58N7O18P3S/c1-4-5-6-7-8-9-10-11-12-13-23(43)18-26(45)64-17-16-37-25(44)14-15-38-33(48)30(47)35(2,3)20-57-63(54,55)60-62(52,53)56-19-24-29(59-61(49,50)51)28(46)34(58-24)42-22-41-27-31(36)39-21-40-32(27)42/h8-9,11-12,21-24,28-30,34,43,46-47H,4-7,10,13-20H2,1-3H3,(H,37,44)(H,38,48)(H,52,53)(H,54,55)(H2,36,39,40)(H2,49,50,51)/p-4/b9-8-,12-11-/t23-,24-,28+,29+,30u,34-/m0/s1 EHMN_ABBREVIATION: CE2417
is: SBO:0000247
initial concentration: 1.0
initial amount: NaN
boundary condition: false
is: CHEBI:28387

metaR r2137
fast: false
reactant: MODEL1310110045#
product: MODEL1310110045#
modifier: MODEL1310110045#
is described by: ECO:0000000
name: Major Facilitator(MFS) TCDB:2.A.1.14.6
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12811560 NOTES:
kinetic law: MODEL1310110045#
type: Reaction
reversible: true
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110045#_9aa1cdac_5dec_4527_9a55_80573b926ea3
initial amount: NaN
has part: O60762
is: SBO:0000297
constant: false
is encoded by: hsa:54344
has part: O94777
name: DPM3:DPM1:DPM2
has only substance units: false
is encoded by: hsa:8813
initial concentration: NaN
boundary condition: true
has part: Q86TM7
is encoded by: hsa:8818
type: Species

metaM omhpal c
constant: false
has only substance units: false
notes: FORMULA: C16H30O3 CHARGE: -1
initial amount: NaN
is: SBO:0000247
is: HMDB06294
initial concentration: 1.0
boundary condition: false
name: w-hydroxypalmiticacid
type: Species

metaR ASPNATm
notes: GENE_ASSOCIATION: SUBSYSTEM: Alanine and aspartate metabolism EC Number: 2.3.1.17 Confidence Level: 4 AUTHORS: PMID:11279290 NOTES:MM
reversible: false
reactant: MODEL1310110045#
type: Reaction
product: MODEL1310110045#
name: aspartate N-acetyltransferase, mitochondrial
is described by: ECO:0000000
kinetic law: MODEL1310110045#
is: SBO:0000176
fast: false

metaM amp e
is: SBO:0000247
type: Species
is: C00020
notes: FORMULA: C10H12N5O7P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00030 EHMN_ABBREVIATION: C00020
is: CHEBI:456215
initial amount: NaN
constant: false
initial concentration: 1.0
name: AMP
is: HMDB00045
boundary condition: false
has only substance units: false

metaR KYNATESYN
reversible: false
type: Reaction
is described by: ECO:0000000
fast: false
reactant: MODEL1310110045#
product: MODEL1310110045#
name: 4-(2-Aminophenyl)-2,4-dioxobutanoate dehydratase
kinetic law: MODEL1310110045#
notes: GENE_ASSOCIATION: SUBSYSTEM: Tryptophan metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:15016471,PMID:16008534 NOTES:SAB name is a guess
is: SBO:0000176

metaM aacoa x
boundary condition: false
type: Species
is: HMDB01484
is: SBO:0000247
constant: false
initial concentration: 1.0
is: CHEBI:57286
has only substance units: false
initial amount: NaN
notes: FORMULA: C25H36N7O18P3S CHARGE: -4 INCHI: InChI=1S/C25H40N7O18P3S/c1-13(33)8-16(35)54-7-6-27-15(34)4-5-28-23(38)20(37)25(2,3)10-47-53(44,45)50-52(42,43)46-9-14-19(49-51(39,40)41)18(36)24(48-14)32-12-31-17-21(26)29-11-30-22(17)32/h11-12,14,18-20,24,36-37H,4-10H2,1-3H3,(H,27,34)(H,28,38)(H,42,43)(H,44,45)(H2,26,29,30)(H2,39,40,41)/p-4/t14-,18-,19-,20+,24-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00282 EHMN_ABBREVIATION: C00332
name: acetoacetyl-CoA(4-)

metaR r0734
reversible: false
name: (S)-Hydroxyhexanoyl-CoA hydro-lyase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:4.2.1.17
reactant: MODEL1310110045#
is described by: ECO:0000000
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.17 Confidence Level: 0 AUTHORS: PMID:8012501,PMID:8188243 NOTES:
product: MODEL1310110045#
kinetic law: MODEL1310110045#
is: SBO:0000176
fast: false

http://identifiers.org/biomodels.db/MODEL1310110045#_ae3116dc_0837_4856_a9e1_8a77d899367a
constant: false
has only substance units: false
name: _J03866_1_m
boundary condition: true
initial amount: NaN
is encoded by: hsa:J03866
initial concentration: NaN
type: Species
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110045#_55873861_6896_4fd6_a7e1_fc86b63f5187
type: Species
name: PIK3C2G
constant: false
initial concentration: NaN
is encoded by: hsa:5288
boundary condition: true
initial amount: NaN
is: SBO:0000252
has only substance units: false
is: O75747

metaR r2136
type: Reaction
reversible: false
name: Major Facilitator(MFS) TCDB:2.A.1.14.6
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12811560 NOTES:
modifier: MODEL1310110045#
kinetic law: MODEL1310110045#
is: SBO:0000185
fast: false
reactant: MODEL1310110045#
product: MODEL1310110045#
is described by: ECO:0000000

metaM q10h2 e
is: HMDB13111
boundary condition: false
notes: FORMULA: C59H92O4 CHARGE: 0 INCHI: InChI=1/C59H92O4/c1-44(2)24-15-25-45(3)26-16-27-46(4)28-17-29-47(5)30-18-31-48(6)32-19-33-49(7)34-20-35-50(8)36-21-37-51(9)38-22-39-52(10)40-23-41-53(11)42-43-55-54(12)56(60)58(62-13)59(63-14)57(55)61/h24,26,28,30,32,34,36,38,40,42,60-61H,15-23,25,27,29,31,33,35,37,39,41,43H2,1-14H3/b45-26+,46-28+,47-30+,48-32+,49-34+,50-36+,51-38+,52-40+,53-42+
is: SBO:0000247
constant: false
has only substance units: false
initial amount: NaN
type: Species
initial concentration: 1.0
name: Ubiquinol-10
is: http://identifiers.org/pubchem.compound/6504740

metaR RE1517M
name: RE1517
is version of: http://identifiers.org/ec-code/1.3.99.13
notes: GENE_ASSOCIATION: (33.1) or (51.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.99.13 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:11356167,PMID:8973539 NOTES:
modifier: MODEL1310110045#
reactant: MODEL1310110045#
product: MODEL1310110045#
type: Reaction
is version of: http://identifiers.org/ec-code/1.3.3.6
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
kinetic law: MODEL1310110045#

http://identifiers.org/biomodels.db/MODEL1310110045#_f1a62fae_7438_477d_9644_4fe87b1d159f
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:7296
has only substance units: false
type: Species
constant: false
is: SBO:0000252
name: TXNRD1
boundary condition: true

metaR r0733
reactant: MODEL1310110045#
kinetic law: MODEL1310110045#
notes: GENE_ASSOCIATION: (8659.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.1.1.35 Confidence Level: 0 AUTHORS: PMID:10231530,PMID:10329704,PMID:1550553,PMID:1651711,PMID:7150615,PMID:8188243,PMID:8687463,PMID:9553139 NOTES:
is version of: http://identifiers.org/ec-code/1.5.1.12
name: (S)-Hydroxyhexanoyl-CoA:NAD+ oxidoreductase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:1.1.1.211 EC:1.1.1.35
is described by: ECO:0000000
type: Reaction
product: MODEL1310110045#
reversible: false
modifier: MODEL1310110045#
is: SBO:0000176
fast: false

http://identifiers.org/biomodels.db/MODEL1310110045#_7db4f799_0589_47c0_bae5_6da2dd5e37a6
is encoded by: hsa:2348
boundary condition: true
initial amount: NaN
is: SBO:0000252
name: FOLR1
constant: false
type: Species
has only substance units: false
initial concentration: NaN

metaR DURAD
is: SBO:0000176
kinetic law: MODEL1310110045#
product: MODEL1310110045#
name: dihydrouracil dehydrogenase (NADP)
reversible: true
type: Reaction
fast: false
is version of: http://identifiers.org/ec-code/1.3.1.2
notes: GENE_ASSOCIATION: (1806.1) SUBSYSTEM: Pyrimidine catabolism EC Number: 1.3.1.2 Confidence Level: 4 AUTHORS: PMID:1512248,PMID:8221682 NOTES:_01-26-05 IT based on Lu et al., JBC,1992,24,17102-17109
reactant: MODEL1310110045#
modifier: MODEL1310110045#
is described by: ECO:0000269

http://identifiers.org/biomodels.db/MODEL1310110045#_0bcae389_62be_4cab_b6d8_d373b9113702
is: GO:0005739
is: SBO:0000290
constant: false
size: 1.0
spatial dimensions: 3.0
name: mitochondrion
type: Compartment

http://identifiers.org/biomodels.db/MODEL1310110045#_0d9c4ba3_eb1f_4170_b0a7_7780848498a8
type: Species
is: P23786
boundary condition: true
is: SBO:0000252
is encoded by: hsa:1376
initial amount: NaN
initial concentration: NaN
name: CPT2
has only substance units: false
constant: false

http://identifiers.org/biomodels.db/MODEL1310110045#_72749779_61be_489f_a7a0_b0adbfa9d378
has only substance units: false
is: SBO:0000252
constant: false
name: SLC7A10
is encoded by: hsa:56301
boundary condition: true
initial amount: NaN
is: Q9NS82
initial concentration: NaN
type: Species

metaM chito2pdol L c
type: Species
initial concentration: 1.0
constant: false
boundary condition: false
is: CHEBI:12427
initial amount: NaN
name: N,N'-Diacetylchitobiosyldiphosphodolichol, human liver homolog
is: HMDB01196
is: SBO:0000247
notes: FORMULA: C1240H2028N20O170P20 CHARGE: -20 INCHI: InChI=1S/C41H72N2O17P2/c1-25(2)13-9-14-26(3)15-10-16-27(4)17-11-18-28(5)19-12-20-29(6)21-22-55-61(51,52)60-62(53,54)59-41-35(43-31(8)47)38(50)39(33(24-45)57-41)58-40-34(42-30(7)46)37(49)36(48)32(23-44)56-40/h13,15,17,19,29,32-41,44-45,48-50H,9-12,14,16,18,20-24H2,1-8H3,(H,42,46)(H,43,47)(H,51,52)(H,53,54)/b26-15+,27-17+,28-19-/t29?,32-,33-,34-,35-,36-,37-,38-,39-,40+,41-/m1/s1
has only substance units: false

metaM fol m
is: SBO:0000247
is: CHEBI:27470
boundary condition: false
type: Species
notes: FORMULA: C19H18N7O6 CHARGE: -1 INCHI: InChI=1S/C19H19N7O6/c20-19-25-15-14(17(30)26-19)23-11(8-22-15)7-21-10-3-1-9(2-4-10)16(29)24-12(18(31)32)5-6-13(27)28/h1-4,8,12,21H,5-7H2,(H,24,29)(H,27,28)(H,31,32)(H3,20,22,25,26,30)/t12-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00396 EHMN_ABBREVIATION: C00504
is: HMDB00121
initial concentration: 1.0
initial amount: NaN
has only substance units: false
name: Folate
constant: false

metaM amp c
type: Species
is: C00020
notes: FORMULA: C10H12N5O7P CHARGE: -2
is: SBO:0000247
name: AMP
initial concentration: 1.0
initial amount: NaN
constant: false
is: CHEBI:3322
has only substance units: false
boundary condition: false
is: HMDB00045

metaM gtp c
initial amount: NaN
initial concentration: 1.0
notes: FORMULA: C10H12N5O14P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00051 EHMN_ABBREVIATION: C00044
constant: false
name: GTP
is: HMDB01273
is: SBO:0000247
boundary condition: false
is: C00044
has only substance units: false
type: Species
is: CHEBI:37565

metaR UGALNACtg
is described by: ECO:0000269
type: Reaction
is: SBO:0000185
reactant: MODEL1310110045#
kinetic law: MODEL1310110045#
reversible: true
notes: GENE_ASSOCIATION: (7355.1) SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 4 AUTHORS: PMID:11784306,PMID:8889805,PMID:9010752,PMID:9399569,PMID:9562625 NOTES:NCD
modifier: MODEL1310110045#
name: UDP-GalNAc Golgi transport via CMP antiport
product: MODEL1310110045#
fast: false

metaR PAIL45P HStn
type: Reaction
reversible: true
is described by: ECO:0000000
product: MODEL1310110045#
is: SBO:0000185
name: phosphatidylinositol 4,5-bisphosphate nuclear transport (diffusion)
reactant: MODEL1310110045#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 1 AUTHORS: NOTES:
kinetic law: MODEL1310110045#

metaR r0732
is: SBO:0000176
name: Hexanoyl-CoA:acetyl-CoA C-acyltransferase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:2.3.1.16
product: MODEL1310110045#
reversible: false
fast: false
reactant: MODEL1310110045#
kinetic law: MODEL1310110045#
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.16 Confidence Level: 0 AUTHORS: PMID:1121274,PMID:1679347,PMID:3194209,PMID:6378901,PMID:8241273 NOTES:
is described by: ECO:0000000
type: Reaction

metaM lnlccoa m
type: Species
notes: FORMULA: C39H62N7O17P3S CHARGE: -4 INCHI: InChI=1/C39H66N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-30(48)67-23-22-41-29(47)20-21-42-37(51)34(50)39(2,3)25-60-66(57,58)63-65(55,56)59-24-28-33(62-64(52,53)54)32(49)38(61-28)46-27-45-31-35(40)43-26-44-36(31)46/h8-9,11-12,26-28,32-34,38,49-50H,4-7,10,13-25H2,1-3H3,(H,41,47)(H,42,51)(H,55,56)(H,57,58)(H2,40,43,44)(H2,52,53,54)/b9-8+,12-11+ HEPATONET_1.0_ABBREVIATION: HC01983
constant: false
has only substance units: false
is: HMDB01064
is: http://identifiers.org/pubchem.compound/5462164
boundary condition: false
is: SBO:0000247
initial concentration: 1.0
initial amount: NaN
name: linoleic coenzyme A

metaR UDPDOLPT L
kinetic law: MODEL1310110045#
is version of: http://identifiers.org/ec-code/2.4.1.117
is described by: ECO:0000000
reactant: MODEL1310110045#
product: MODEL1310110045#
name: UDPglucose:dolichyl-phosphate beta-D-glucosyltransferase (liver)
notes: GENE_ASSOCIATION: (29880.1) SUBSYSTEM: N-glycan synthesis EC Number: 2.4.1.117 Confidence Level: 0 AUTHORS: PMID:8280060 NOTES:NCD
is: SBO:0000176
type: Reaction
reversible: false
fast: false
modifier: MODEL1310110045#

metaR CHOLESTle
product: MODEL1310110045#
modifier: MODEL1310110045#
reversible: false
reactant: MODEL1310110045#
kinetic law: MODEL1310110045#
is version of: http://identifiers.org/ec-code/3.1.1.13
name: hydrolysis of cholesterol ester by cholesterol esterase
is described by: ECO:0000134
type: Reaction
notes: GENE_ASSOCIATION: (3988.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
is: SBO:0000176
fast: false

metaM gua e
type: Species
is: HMDB00132
name: guanine
is: SBO:0000247
initial concentration: 1.0
notes: FORMULA: C5H5N5O CHARGE: 0 INCHI: InChI=1S/C5H5N5O/c6-5-9-3-2(4(11)10-5)7-1-8-3/h1H,(H4,6,7,8,9,10,11) HEPATONET_1.0_ABBREVIATION: HC00219 EHMN_ABBREVIATION: C00242
boundary condition: false
is: CHEBI:16235
initial amount: NaN
has only substance units: false
constant: false

metaM q10h2 c
is: SBO:0000247
constant: false
type: Species
name: Ubiquinol-10
notes: FORMULA: C59H92O4 CHARGE: 0 INCHI: InChI=1/C59H92O4/c1-44(2)24-15-25-45(3)26-16-27-46(4)28-17-29-47(5)30-18-31-48(6)32-19-33-49(7)34-20-35-50(8)36-21-37-51(9)38-22-39-52(10)40-23-41-53(11)42-43-55-54(12)56(60)58(62-13)59(63-14)57(55)61/h24,26,28,30,32,34,36,38,40,42,60-61H,15-23,25,27,29,31,33,35,37,39,41,43H2,1-14H3/b45-26+,46-28+,47-30+,48-32+,49-34+,50-36+,51-38+,52-40+,53-42+ HEPATONET_1.0_ABBREVIATION: HC00324
boundary condition: false
is: http://identifiers.org/pubchem.compound/6504740
initial amount: NaN
is: HMDB13111
has only substance units: false
initial concentration: 1.0

metaM ditp n
is: SBO:0000247
name: dITP(4-)
has only substance units: false
type: Species
is: HMDB03537
initial concentration: 1.0
initial amount: NaN
notes: FORMULA: C10H11N4O13P3 CHARGE: -4 INCHI: InChI=1S/C10H15N4O13P3/c15-5-1-7(14-4-13-8-9(14)11-3-12-10(8)16)25-6(5)2-24-29(20,21)27-30(22,23)26-28(17,18)19/h3-7,15H,1-2H2,(H,20,21)(H,22,23)(H,11,12,16)(H2,17,18,19)/p-4/t5-,6+,7+/m0/s1 EHMN_ABBREVIATION: C01345
is: CHEBI:61382
constant: false
boundary condition: false

metaM akg c
is: HMDB00208
is: CHEBI:16810
has only substance units: false
boundary condition: false
initial concentration: 1.0
is: C00026
is: SBO:0000247
notes: FORMULA: C5H4O5 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00035 EHMN_ABBREVIATION: C00026
constant: false
name: 2-Oxoglutarate
initial amount: NaN
type: Species

metaM acnam c
initial amount: NaN
name: N-acetylneuraminate
constant: false
is: CHEBI:35418
is: SBO:0000247
type: Species
has only substance units: false
boundary condition: false
notes: FORMULA: C11H18NO9 CHARGE: -1 INCHI: InChI=1S/C11H19NO9/c1-4(14)12-7-5(15)2-11(20,10(18)19)21-9(7)8(17)6(16)3-13/h5-9,13,15-17,20H,2-3H2,1H3,(H,12,14)(H,18,19)/p-1/t5-,6+,7+,8+,9+,11?/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00244 EHMN_ABBREVIATION: C00270
is: HMDB00230
initial concentration: 1.0

metaM r5p c
has only substance units: false
boundary condition: false
initial concentration: 1.0
name: alpha-D-Ribose 5-phosphate
constant: false
notes: FORMULA: C5H9O8P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00115 EHMN_ABBREVIATION: C00117
is: SBO:0000247
type: Species
is: CHEBI:18189
initial amount: NaN
is: C00117
is: HMDB00618

metaM h2o l
is: SBO:0000247
is: HMDB02111
initial concentration: 1.0
type: Species
is: CHEBI:15377
initial amount: NaN
constant: false
has only substance units: false
boundary condition: false
name: water
notes: FORMULA: H2O CHARGE: 0 INCHI: InChI=1S/H2O/h1H2 HEPATONET_1.0_ABBREVIATION: HC00011 EHMN_ABBREVIATION: C00001

metaR r2133
reversible: true
reactant: MODEL1310110045#
product: MODEL1310110045#
is: SBO:0000185
modifier: MODEL1310110045#
kinetic law: MODEL1310110045#
is described by: ECO:0000000
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
fast: false
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110045#_da4d1256_fc59_4109_93ee_7ab518932ea1
has part: A7E2E0
has part: Q92569
constant: false
type: Species
initial concentration: NaN
is: SBO:0000297
initial amount: NaN
name: PIK3CD:PIK3R3
is encoded by: hsa:8503
is encoded by: hsa:5293
boundary condition: true
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110045#_2dbbbd8c_ca89_4516_a56e_fa997620a67e
is: GO:0005737
is: SBO:0000290
constant: false
size: 1.0
spatial dimensions: 3.0
name: cytoplasm
type: Compartment

metaR ILETA
kinetic law: MODEL1310110045#
reversible: true
type: Reaction
product: MODEL1310110045#
fast: false
reactant: MODEL1310110045#
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/2.6.1.42
notes: GENE_ASSOCIATION: (586.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 2.6.1.42 Confidence Level: 4 AUTHORS: PMID:6933702,PMID:9165094 NOTES:
is: SBO:0000176
name: isoleucine transaminase
modifier: MODEL1310110045#

metaM 2octdectecoa m
constant: false
notes: FORMULA: C39H58N7O17P3S CHARGE: -4
boundary condition: false
initial amount: NaN
is: SBO:0000247
type: Species
has only substance units: false
name: 2,6,9,12-octadecatetraenoylcoa
initial concentration: 1.0
is: HMDB06294

metaR r0509
is described by: ECO:0000000
type: Reaction
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Citric acid cycle EC Number: 1.3.5.1 Confidence Level: 0 AUTHORS: PMID:2843227 NOTES:
is: SBO:0000176
reactant: MODEL1310110045#
product: MODEL1310110045#
reversible: false
name: Succinate:ubiquinone oxidoreductase Citrate cycle (TCA cycle) EC:1.3.5.1
kinetic law: MODEL1310110045#

metaM xu5p D c
initial amount: NaN
type: Species
initial concentration: 1.0
has only substance units: false
is: SBO:0000247
name: D-xylulose 5-phosphate(2-)
is: HMDB00868
is: CHEBI:57737
constant: false
notes: FORMULA: C5H9O8P CHARGE: -2 INCHI: InChI=1S/C5H11O8P/c6-1-3(7)5(9)4(8)2-13-14(10,11)12/h4-6,8-9H,1-2H2,(H2,10,11,12)/p-2/t4-,5-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00209
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110045#_693bd4e6_2d00_4484_9811_ded50adbf2c5
is encoded by: hsa:AI971036
boundary condition: true
constant: false
type: Species
has only substance units: false
initial concentration: NaN
name: _AI971036_1_c
is: SBO:0000252
initial amount: NaN

metaR r0731
kinetic law: MODEL1310110045#
product: MODEL1310110045#
is described by: ECO:0000000
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.17 Confidence Level: 0 AUTHORS: PMID:8012501,PMID:8188243 NOTES:
reversible: false
is: SBO:0000176
name: (S)-Hydroxyoctanoyl-CoA hydro-lyase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:4.2.1.17
fast: false
reactant: MODEL1310110045#

metaR P450SCC1m
reversible: true
reactant: MODEL1310110045#
product: MODEL1310110045#
is: SBO:0000176
name: cholesterol monooxygenase
type: Reaction
fast: false
is described by: ECO:0000134
kinetic law: MODEL1310110045#
notes: GENE_ASSOCIATION: SUBSYSTEM: Cholesterol metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:1525048 NOTES:Acting on paired donors with incorporation of molecular oxygen With a reduced iron-sulfur protein as one donor, and incorporation of one atom of oxygen

metaR ACNAMlt
name: N-acetylneuraminate transport into lysososme
reversible: true
is described by: ECO:0000269
fast: false
reactant: MODEL1310110045#
type: Reaction
is: SBO:0000185
product: MODEL1310110045#
modifier: MODEL1310110045#
notes: GENE_ASSOCIATION: (26503.1) SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 4 AUTHORS: PMID:10581036,PMID:2768261 NOTES:H symport into lysososome. See PMID: 2768261 and PMID: 10581036 ( for human evidence). Sialic acid storage disorders (due to transporter mutations) require import and export e.g. PMID: 2768266 NJ
kinetic law: MODEL1310110045#

metaM h2o e
has only substance units: false
is: SBO:0000247
is: CHEBI:15377
constant: false
initial amount: NaN
initial concentration: 1.0
boundary condition: false
is: HMDB02111
name: H2O
is: C00001
type: Species
notes: FORMULA: H2O CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00011 EHMN_ABBREVIATION: C00001

http://identifiers.org/biomodels.db/MODEL1310110045#_5731a3b4_c0cf_45b2_9a24_6b0899024e2e
initial concentration: NaN
is encoded by: hsa:6392
boundary condition: true
is: O14521
is: SBO:0000252
name: SDHD
constant: false
has only substance units: false
initial amount: NaN
type: Species

metaR r2132
type: Reaction
kinetic law: MODEL1310110045#
reversible: true
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
fast: false
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
modifier: MODEL1310110045#
reactant: MODEL1310110045#
product: MODEL1310110045#
is: SBO:0000185
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110045#_e4aa84b2_bd72_49c6_9528_941860b3deea
name: GLUD1
has only substance units: false
constant: false
is encoded by: hsa:2746
is: E9KL48
initial concentration: NaN
initial amount: NaN
type: Species
boundary condition: true
is: SBO:0000252

metaM Lpipecol x
notes: FORMULA: C6H11NO2 CHARGE: 0 INCHI: InChI=1S/C6H11NO2/c8-6(9)5-3-1-2-4-7-5/h5,7H,1-4H2,(H,8,9)/t5-/m0/s1 EHMN_ABBREVIATION: C00408
type: Species
boundary condition: false
is: CHEBI:30913
initial concentration: 1.0
has only substance units: false
is: SBO:0000247
initial amount: NaN
name: L-pipecolic acid
constant: false
is: HMDB00716

http://identifiers.org/biomodels.db/MODEL1310110045#_66c7e87b_628c_45ab_8a2b_b89878763676
initial concentration: NaN
boundary condition: true
is: SBO:0000252
is encoded by: hsa:H53099
type: Species
constant: false
has only substance units: false
name: _H53099_1_m
initial amount: NaN

metaR r0730
product: MODEL1310110045#
is: SBO:0000176
name: (S)-Hydroxyoctanoyl-CoA:NAD+ oxidoreductase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:1.1.1.211
modifier: MODEL1310110045#
reversible: false
notes: GENE_ASSOCIATION: (34.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.1.1.211 Confidence Level: 0 AUTHORS: PMID:10231530,PMID:10329704,PMID:1550553,PMID:1651711,PMID:7150615,PMID:8188243,PMID:8687463,PMID:9553139 NOTES:
fast: false
reactant: MODEL1310110045#
is described by: ECO:0000000
type: Reaction
kinetic law: MODEL1310110045#
is version of: http://identifiers.org/ec-code/1.3.99.3

http://identifiers.org/biomodels.db/MODEL1310110045#_ffd4d999_b3a1_4e78_9f97_1d23bc66fd59
boundary condition: true
initial concentration: NaN
constant: false
type: Species
is encoded by: hsa:7086
has only substance units: false
initial amount: NaN
is: E7EPA7
name: TKT
is: SBO:0000252

metaM dad 2 e
has only substance units: false
initial amount: NaN
name: 2-deoxyadenosine
type: Species
notes: FORMULA: C10H13N5O3 CHARGE: 0 INCHI: InChI=1S/C10H13N5O3/c11-9-8-10(13-3-12-9)15(4-14-8)7-1-5(17)6(2-16)18-7/h3-7,16-17H,1-2H2,(H2,11,12,13)/t5-,6+,7+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00431
is: SBO:0000247
initial concentration: 1.0
boundary condition: false
is: HMDB00101
constant: false
is: CHEBI:17256

http://identifiers.org/biomodels.db/MODEL1310110045#_351c5a1d_878a_4cae_b468_67f2fbad6227
initial amount: NaN
boundary condition: true
initial concentration: NaN
constant: false
has only substance units: false
name: ALDH1A2
is: SBO:0000252
is: O94788
type: Species
is encoded by: hsa:8854

metaM biocyt c
boundary condition: false
is: SBO:0000247
constant: false
notes: FORMULA: C16H28N4O4S CHARGE: 0 INCHI: InChI=1/C16H28N4O4S/c17-10(15(22)23)5-3-4-8-18-13(21)7-2-1-6-12-14-11(9-25-12)19-16(24)20-14/h10-12,14H,1-9,17H2,(H,18,21)(H,22,23)(H2,19,20,24)/t10-,11-,12-,14-/m0/s1 EHMN_ABBREVIATION: C05552
has only substance units: false
initial concentration: 1.0
type: Species
is: C05552
initial amount: NaN
is: http://identifiers.org/pubchem.compound/7886
name: Biocytin
is: HMDB03134

metaM ksi deg33 l
is: HMDB00143
type: Species
constant: false
is: SBO:0000247
has only substance units: false
initial amount: NaN
initial concentration: 1.0
boundary condition: false
notes: FORMULA: C76H125N5O62S2 CHARGE: -2
name: keratan sulfate I, degradation product 33
is: CHEBI:12936

metaM akg e
constant: false
type: Species
notes: FORMULA: C5H4O5 CHARGE: -2 INCHI: InChI=1S/C5H6O5/c6-3(5(9)10)1-2-4(7)8/h1-2H2,(H,7,8)(H,9,10)/p-2 HEPATONET_1.0_ABBREVIATION: HC00035 EHMN_ABBREVIATION: C00026
is: SBO:0000247
boundary condition: false
name: 2-oxoglutarate(2-)
initial amount: NaN
has only substance units: false
initial concentration: 1.0
is: HMDB00208
is: CHEBI:16810

http://identifiers.org/biomodels.db/MODEL1310110045#_37cdb942_5b96_4eb0_a081_b7ff87413a81
constant: false
is encoded by: hsa:5831
name: PYCR1
type: Species
boundary condition: true
initial amount: NaN
initial concentration: NaN
has only substance units: false
is: P32322
is: SBO:0000252

metaM Lcystin c
initial concentration: 1.0
initial amount: NaN
is: SBO:0000247
constant: false
is: CHEBI:16283
name: L-cystine
boundary condition: false
notes: FORMULA: C6H12N2O4S2 CHARGE: 0 INCHI: InChI=1S/C6H12N2O4S2/c7-3(5(9)10)1-13-14-2-4(8)6(11)12/h3-4H,1-2,7-8H2,(H,9,10)(H,11,12)/t3-,4-/m0/s1
has only substance units: false
type: Species
is: HMDB00192

metaR RE3367E
fast: false
notes: GENE_ASSOCIATION: (26.1) SUBSYSTEM: Urea cycle EC Number: 1.4.3.6 Confidence Level: 0 AUTHORS: PMID:10047787,PMID:7040832 NOTES:
reactant: MODEL1310110045#
is described by: ECO:0000000
modifier: MODEL1310110045#
product: MODEL1310110045#
name: RE3367
is: SBO:0000176
reversible: false
kinetic law: MODEL1310110045#
type: Reaction
is version of: http://identifiers.org/ec-code/1.4.3.22

metaR r2131
type: Reaction
reversible: true
product: MODEL1310110045#
modifier: MODEL1310110045#
reactant: MODEL1310110045#
is: SBO:0000185
kinetic law: MODEL1310110045#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
fast: false
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110045#_05fe84ff_a2eb_40fa_a618_de8b17533500
constant: false
is: SBO:0000252
boundary condition: true
has only substance units: false
is: P00374
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:1719
name: DHFR
type: Species

metaM naglc2p L c
boundary condition: false
initial concentration: 1.0
has only substance units: false
is: CHEBI:18278
type: Species
name: N-Acetyl-D-glucosaminyldiphosphodolichol, human liver homolog
notes: FORMULA: C1160H1898N10O120P20 CHARGE: -20 INCHI: InChI=1S/C33H59NO12P2/c1-23(2)12-8-13-24(3)14-9-15-25(4)16-10-17-26(5)18-11-19-27(6)20-21-43-47(39,40)46-48(41,42)45-33-30(34-28(7)36)32(38)31(37)29(22-35)44-33/h12,14,16,18,27,29-33,35,37-38H,8-11,13,15,17,19-22H2,1-7H3,(H,34,36)(H,39,40)(H,41,42)/b24-14+,25-16+,26-18-/t27?,29-,30-,31-,32-,33-/m1/s1
initial amount: NaN
is: SBO:0000247
constant: false

metaM h2o g
constant: false
name: water
is: CHEBI:15377
has only substance units: false
initial amount: NaN
is: HMDB02111
initial concentration: 1.0
boundary condition: false
notes: FORMULA: H2O CHARGE: 0 INCHI: InChI=1S/H2O/h1H2 HEPATONET_1.0_ABBREVIATION: HC00011 EHMN_ABBREVIATION: C00001
type: Species
is: SBO:0000247

metaM g1m8mpdol L r
initial concentration: 1.0
notes: FORMULA: C1840H3028N20O670P20 CHARGE: -20
type: Species
is: C05870
boundary condition: false
name: alpha-D-Glucosyl-(alpha-D-mannosyl)8-beta-D-mannosyl-diacetylchitobiosyldiphosphodolichol, human liver homolog
is: SBO:0000247
constant: false
initial amount: NaN
has only substance units: false

metaR F1PGT
product: MODEL1310110045#
is version of: http://identifiers.org/ec-code/2.7.7.30
reversible: true
notes: GENE_ASSOCIATION: (8790.1) SUBSYSTEM: Fructose and mannose metabolism EC Number: 2.7.7.30 Confidence Level: 0 AUTHORS: NOTES:NCD
fast: false
type: Reaction
modifier: MODEL1310110045#
is: SBO:0000176
name: fucose-1-phosphate guanylyltransferase
is described by: ECO:0000000
kinetic law: MODEL1310110045#
reactant: MODEL1310110045#

http://identifiers.org/biomodels.db/MODEL1310110045#_d8237a80_2278_4b11_bdd0_2a2a9cb8ba1b
initial amount: NaN
is: Q02318
initial concentration: NaN
has only substance units: false
boundary condition: true
is: SBO:0000252
type: Species
is encoded by: hsa:1593
name: CYP27A1
constant: false

http://identifiers.org/biomodels.db/MODEL1310110045#_84132685_a2ab_4aeb_bf83_ebd412003a71
constant: false
initial amount: NaN
type: Species
is: P43251
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:686
has only substance units: false
name: BTD
boundary condition: true

metaR r2130
reactant: MODEL1310110045#
is: SBO:0000185
is described by: ECO:0000000
kinetic law: MODEL1310110045#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
type: Reaction
reversible: true
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
fast: false
modifier: MODEL1310110045#
product: MODEL1310110045#

metaR EX dopa LPAREN e RPAREN
kinetic law: MODEL1310110045#
reactant: MODEL1310110045#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Dopamine exchange
type: Reaction

metaR r1610
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
kinetic law: MODEL1310110045#
reversible: true
is described by: ECO:0000000
type: Reaction
reactant: MODEL1310110045#
fast: false
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
product: MODEL1310110045#

metaM CE4872 c
initial amount: NaN
constant: false
is: HMDB00127
is: CHEBI:15748
has only substance units: false
boundary condition: false
type: Species
is: SBO:0000247
name: 3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-27-al
notes: FORMULA: C27H46O4 CHARGE: 0 INCHI: InChI=1/C27H46O4/c1-16(15-28)6-5-7-17(2)20-8-9-21-25-22(14-24(31)27(20,21)4)26(3)11-10-19(29)12-18(26)13-23(25)30/h15-25,29-31H,5-14H2,1-4H3/t16u,17-,18-,19+,20-,21-,22-,23+,24-,25-,26?,27-/m1/s1 EHMN_ABBREVIATION: CE4872
initial concentration: 1.0

metaM clpndcoa c
is: SBO:0000247
notes: FORMULA: C43H64N7O17P3S CHARGE: -4 INCHI: InChI=1/C43H68N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-34(52)71-27-26-45-33(51)24-25-46-41(55)38(54)43(2,3)29-64-70(61,62)67-69(59,60)63-28-32-37(66-68(56,57)58)36(53)42(65-32)50-31-49-35-39(44)47-30-48-40(35)50/h5-6,8-9,11-12,14-15,17-18,30-32,36-38,42,53-54H,4,7,10,13,16,19-29H2,1-3H3,(H,45,51)(H,46,55)(H,59,60)(H,61,62)(H2,44,47,48)(H2,56,57,58)/p-4/b6-5-,9-8-,12-11-,15-14-,18-17-/t32-,36+,37+,38?,42-/m0/s1
type: Species
has only substance units: false
constant: false
name: clupanodonyl CoA
is: HMDB06267
boundary condition: false
initial amount: NaN
initial concentration: 1.0
is: http://identifiers.org/pubchem.compound/47205476
is: C16166

metaM dad 2 c
is: SBO:0000247
initial amount: NaN
has only substance units: false
initial concentration: 1.0
notes: FORMULA: C10H13N5O3 CHARGE: 0 INCHI: InChI=1S/C10H13N5O3/c11-9-8-10(13-3-12-9)15(4-14-8)7-1-5(17)6(2-16)18-7/h3-7,16-17H,1-2H2,(H2,11,12,13)/t5-,6+,7+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00431
name: 2-deoxyadenosine
constant: false
is: CHEBI:17256
type: Species
is: HMDB00101
boundary condition: false

metaR r0881
type: Reaction
is described by: ECO:0000000
kinetic law: MODEL1310110045#
name: Active transport
is: SBO:0000185
fast: false
reactant: MODEL1310110045#
reversible: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12107270,PMID:12739169,PMID:12829793,PMID:17245649,PMID:18375207,PMID:8476015,PMID:8557697,PMID:9786900 NOTES:
product: MODEL1310110045#

metaR ADPT
is version of: http://identifiers.org/ec-code/2.4.2.7
product: MODEL1310110045#
name: adenine phosphoribosyltransferase
reversible: false
kinetic law: MODEL1310110045#
type: Reaction
fast: false
reactant: MODEL1310110045#
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (353.1) SUBSYSTEM: Nucleotide salvage pathway EC Number: 2.4.2.7 Confidence Level: 4 AUTHORS: PMID:14674717,PMID:15196008 NOTES:
modifier: MODEL1310110045#
is: SBO:0000176

metaM lnlccoa r
notes: FORMULA: C39H62N7O17P3S CHARGE: -4 INCHI: InChI=1/C39H66N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-30(48)67-23-22-41-29(47)20-21-42-37(51)34(50)39(2,3)25-60-66(57,58)63-65(55,56)59-24-28-33(62-64(52,53)54)32(49)38(61-28)46-27-45-31-35(40)43-26-44-36(31)46/h8-9,11-12,26-28,32-34,38,49-50H,4-7,10,13-25H2,1-3H3,(H,41,47)(H,42,51)(H,55,56)(H,57,58)(H2,40,43,44)(H2,52,53,54)/b9-8+,12-11+ HEPATONET_1.0_ABBREVIATION: HC01983
is: SBO:0000247
constant: false
type: Species
has only substance units: false
is: HMDB01064
initial concentration: 1.0
initial amount: NaN
boundary condition: false
is: http://identifiers.org/pubchem.compound/5462164
name: linoleic coenzyme A

http://identifiers.org/biomodels.db/MODEL1310110045#_3facd05e_e55a_48f5_a06e_a7fb14aad1f7
is: Q9UGH3
is: SBO:0000252
type: Species
initial concentration: NaN
initial amount: NaN
constant: false
boundary condition: true
is encoded by: hsa:9962
name: SLC23A2
has only substance units: false

metaR PI5P3K
type: Reaction
is version of: http://identifiers.org/ec-code/2.7.1.137
reversible: false
is version of: http://identifiers.org/ec-code/2.7.11.1
reactant: MODEL1310110045#
fast: false
modifier: MODEL1310110045#
is described by: ECO:0000000
kinetic law: MODEL1310110045#
product: MODEL1310110045#
notes: GENE_ASSOCIATION: (5295.2 and 5291.1) or (23533.1 and 5294.1) or (5295.2 and 5290.1) or (5293.1 and 5295.3) or (5287.1) or (5286.1) or (5293.1 and 5296.1) or (5295.2 and 5293.1) or (5296.1 and 5291.1) or (5290.1 and 5295.1) or (5288.1) or (5290.1 and 8503.1) or (5291.1 and 5295.3) or (10870.1 and 5294.1) or (5291.1 and 8503.1) or (5293.1 and 5295.1) or (5296.1 and 5290.1) or (5289.1) or (5293.1 and 8503.1) or (5291.1 and 5295.1) or (5290.1 and 5295.3) SUBSYSTEM: Inositol phosphate metabolism EC Number: Confidence Level: 1 AUTHORS: PMID:10358929 NOTES:NCD
name: phosphatidylinositol-5-phosphate 3-kinase
is version of: http://identifiers.org/ec-code/2.7.1.153
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.7.1.154

metaM thmpp m
initial amount: NaN
initial concentration: 1.0
is: CHEBI:45931
constant: false
boundary condition: false
is: HMDB01372
type: Species
has only substance units: false
name: Thiamine diphosphate
notes: FORMULA: C12H16N4O7P2S CHARGE: -2 INCHI: InChI=1S/C12H18N4O7P2S/c1-8-11(3-4-22-25(20,21)23-24(17,18)19)26-7-16(8)6-10-5-14-9(2)15-12(10)13/h5,7H,3-4,6H2,1-2H3,(H4-,13,14,15,17,18,19,20,21) HEPATONET_1.0_ABBREVIATION: HC00071 EHMN_ABBREVIATION: C00068
is: SBO:0000247

metaR FUCASEly
is version of: http://identifiers.org/ec-code/3.2.1.51
kinetic law: MODEL1310110045#
modifier: MODEL1310110045#
reversible: false
product: MODEL1310110045#
type: Reaction
is: SBO:0000176
notes: GENE_ASSOCIATION: (2517.1) SUBSYSTEM: N-glycan degradation EC Number: 3.2.1.51 Confidence Level: 0 AUTHORS: NOTES:NCD
reactant: MODEL1310110045#
fast: false
name: alpha-fucosidase, lysosomal
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110045#_14057e32_e1d0_4fbd_9c4a_8e9567c57eb3
is encoded by: hsa:9651
type: Species
is: O75038
initial amount: NaN
boundary condition: true
is: SBO:0000252
constant: false
has only substance units: false
name: PLCH2
initial concentration: NaN

metaR PTRCOX1
modifier: MODEL1310110045#
is described by: ECO:0000304
name: Putrescine:oxygen oxidoreductase (deaminating)
reversible: false
type: Reaction
is version of: http://identifiers.org/ec-code/1.4.3.22
kinetic law: MODEL1310110045#
fast: false
product: MODEL1310110045#
is version of: http://identifiers.org/ec-code/1.4.3.21
is: SBO:0000176
reactant: MODEL1310110045#
notes: GENE_ASSOCIATION: (26.1) or (314.1) or (8639.1) or (314.2) SUBSYSTEM: Arginine and Proline Metabolism EC Number: 1.4.3.6 Confidence Level: 2 AUTHORS: PMID:9119395 NOTES:SAB

http://identifiers.org/biomodels.db/MODEL1310110045#_704d8c2e_aa61_44a7_a4fa_848392c1ca16
initial concentration: NaN
is encoded by: hsa:2180
is: P33121
is: SBO:0000252
has only substance units: false
initial amount: NaN
constant: false
name: ACSL1
boundary condition: true
type: Species

metaR RE2651R
fast: false
type: Reaction
kinetic law: MODEL1310110045#
notes: GENE_ASSOCIATION: SUBSYSTEM: Vitamin A metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:9647871 NOTES:
reactant: MODEL1310110045#
is described by: ECO:0000000
name: RE2651
product: MODEL1310110045#
is: SBO:0000176
reversible: true

metaR DOPAt4 2 r
is: SBO:0000185
name: Dopamine reversible transport in via sodium symport (1:2)
fast: false
kinetic law: MODEL1310110045#
reactant: MODEL1310110045#
is described by: ECO:0000269
product: MODEL1310110045#
notes: GENE_ASSOCIATION: (6530.1) or (6531.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12719981 NOTES:SAB
modifier: MODEL1310110045#
type: Reaction
reversible: true

metaM hedepecoa m
notes: FORMULA: C37H52N7O17P3S CHARGE: -4
is: SBO:0000247
boundary condition: false
name: 2,4,7,10,13-hexadecapentenoylcoa
initial amount: NaN
constant: false
is: HMDB02288
has only substance units: false
type: Species
initial concentration: 1.0

metaR r1611
product: MODEL1310110045#
is: SBO:0000185
kinetic law: MODEL1310110045#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
type: Reaction
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reactant: MODEL1310110045#
fast: false
reversible: true

metaM Lcystin e
boundary condition: false
is: HMDB00192
initial concentration: 1.0
initial amount: NaN
constant: false
is: CHEBI:16283
name: L-cystine
notes: FORMULA: C6H12N2O4S2 CHARGE: 0 INCHI: InChI=1S/C6H12N2O4S2/c7-3(5(9)10)1-13-14-2-4(8)6(11)12/h3-4H,1-2,7-8H2,(H,9,10)(H,11,12)/t3-,4-/m0/s1
is: SBO:0000247
has only substance units: false
type: Species

metaM h2o r
is: HMDB02111
is: C00001
boundary condition: false
has only substance units: false
type: Species
is: SBO:0000247
name: H2O
initial amount: NaN
notes: FORMULA: H2O CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00011 EHMN_ABBREVIATION: C00001
initial concentration: 1.0
constant: false
is: CHEBI:15377

http://identifiers.org/biomodels.db/MODEL1310110045#_3a29d497_652e_4b96_bf74_65ef8f42ee41
initial amount: NaN
is: E9PAK4
constant: false
name: SLC5A9
boundary condition: true
is: SBO:0000252
initial concentration: NaN
is encoded by: hsa:200010
type: Species
has only substance units: false

metaM cysam c
constant: false
name: cysteaminium
boundary condition: false
notes: FORMULA: C2H8NS CHARGE: 1 INCHI: InChI=1S/C2H7NS/c3-1-2-4/h4H,1-3H2/p+1 HEPATONET_1.0_ABBREVIATION: HC00823 EHMN_ABBREVIATION: C01678
has only substance units: false
is: CHEBI:58029
initial amount: NaN
is: SBO:0000247
is: HMDB02991
initial concentration: 1.0
type: Species

http://identifiers.org/biomodels.db/MODEL1310110045#_b0596dbe_808d_4b93_b03e_4309f87d1d23
initial amount: NaN
is: SBO:0000252
is encoded by: hsa:5230
type: Species
is: P00558
name: PGK1
initial concentration: NaN
boundary condition: true
has only substance units: false
constant: false

metaR FAOXC18480m
fast: false
is described by: ECO:0000000
product: MODEL1310110045#
is version of: http://identifiers.org/ec-code/1.3.8.1
is version of: http://identifiers.org/ec-code/1.3.99.3
reversible: false
type: Reaction
notes: GENE_ASSOCIATION: (34.1) or (35.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.74 Confidence Level: 4 AUTHORS: NOTES:_5 rounds of beta ox, 4 degrees loss of saturation -> only 1 fad oxidized to fadh2 peroxisomal (very long chain FA) c18:4,n-6 -> c8:0, 4 step FAO lumped for 2 rounds also includes EC 1.1.1.35, 1.1.1.211, 1.3.3.6, 4.2.1.17, 4.2.1.74 NJ
kinetic law: MODEL1310110045#
reactant: MODEL1310110045#
name: Beta oxidation of fatty acid
is: SBO:0000176
modifier: MODEL1310110045#

http://identifiers.org/biomodels.db/MODEL1310110045#_a421c358_d250_43a9_82c9_5290d0f202e2
name: BDH1
is: Q02338
is encoded by: hsa:622
constant: false
has only substance units: false
type: Species
initial concentration: NaN
initial amount: NaN
is: SBO:0000252
boundary condition: true

metaR GALASE7ly
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/3.1.6.4
type: Reaction
name: beta-galactosidase, lysosomal
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) or (5476.1) and (2720.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.23 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD
is version of: http://identifiers.org/ec-code/3.2.1.18
is version of: http://identifiers.org/ec-code/3.2.1.23
modifier: MODEL1310110045#
product: MODEL1310110045#
kinetic law: MODEL1310110045#
is version of: http://identifiers.org/ec-code/3.4.16.5
fast: false
reversible: false
is: SBO:0000176
reactant: MODEL1310110045#

http://identifiers.org/biomodels.db/MODEL1310110045#_929a40ba_d54b_4b74_aea5_d08954c49938
initial concentration: NaN
constant: false
has only substance units: false
is: Q9NYR8
boundary condition: true
is: SBO:0000252
name: RDH8
is encoded by: hsa:50700
initial amount: NaN
type: Species

metaM dolmanp L r
has only substance units: false
initial amount: NaN
is: SBO:0000247
name: Dolichyl phosphate D-mannose, human liver homolog
type: Species
boundary condition: false
constant: false
notes: FORMULA: C1140H1868O90P10 CHARGE: -10 INCHI: InChI=1S/C31H55O9P/c1-22(2)11-7-12-23(3)13-8-14-24(4)15-9-16-25(5)17-10-18-26(6)19-20-38-41(36,37)40-31-30(35)29(34)28(33)27(21-32)39-31/h11,13,15,17,26-35H,7-10,12,14,16,18-21H2,1-6H3,(H,36,37)/b23-13+,24-15+,25-17-/t26?,27-,28-,29+,30+,31?/m1/s1
is: CHEBI:15809
initial concentration: 1.0

metaM amp m
initial concentration: 1.0
has only substance units: false
notes: FORMULA: C10H12N5O7P CHARGE: -2 INCHI: InChI=1S/C10H14N5O7P/c11-8-5-9(13-2-12-8)15(3-14-5)10-7(17)6(16)4(22-10)1-21-23(18,19)20/h2-4,6-7,10,16-17H,1H2,(H2,11,12,13)(H2,18,19,20)/p-2/t4-,6-,7-,10-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00030 EHMN_ABBREVIATION: C00020
name: AMP(2-)
initial amount: NaN
type: Species
is: CHEBI:456215
constant: false
is: HMDB00045
boundary condition: false
is: SBO:0000247

metaR G12MT1 L
fast: false
is described by: ECO:0000000
kinetic law: MODEL1310110045#
type: Reaction
reversible: false
reactant: MODEL1310110045#
name: Glycolipid 1,2-alpha-D-mannosyltransferase (liver)
is: SBO:0000176
product: MODEL1310110045#
notes: GENE_ASSOCIATION: SUBSYSTEM: N-glycan synthesis EC Number: 2.4.1.131 Confidence Level: 0 AUTHORS: NOTES:

metaM lnlccoa c
initial concentration: 1.0
is: HMDB01064
boundary condition: false
initial amount: NaN
has only substance units: false
type: Species
constant: false
notes: FORMULA: C39H62N7O17P3S CHARGE: -4 INCHI: InChI=1/C39H66N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-30(48)67-23-22-41-29(47)20-21-42-37(51)34(50)39(2,3)25-60-66(57,58)63-65(55,56)59-24-28-33(62-64(52,53)54)32(49)38(61-28)46-27-45-31-35(40)43-26-44-36(31)46/h8-9,11-12,26-28,32-34,38,49-50H,4-7,10,13-25H2,1-3H3,(H,41,47)(H,42,51)(H,55,56)(H,57,58)(H2,40,43,44)(H2,52,53,54)/b9-8+,12-11+
is: SBO:0000247
name: linoleic coenzyme A
is: http://identifiers.org/pubchem.compound/5462164

http://identifiers.org/biomodels.db/MODEL1310110045#_bed4ef87_2662_4a8c_b0c7_35fdfed52c9d
has only substance units: false
name: MAN2B1
is: SBO:0000252
is encoded by: hsa:4125
initial amount: NaN
boundary condition: true
initial concentration: NaN
is: O00754
type: Species
constant: false

metaR r1612
notes: GENE_ASSOCIATION: (19.1) or (AL038231.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reactant: MODEL1310110045#
kinetic law: MODEL1310110045#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reversible: true
modifier: MODEL1310110045#
is described by: ECO:0000000
fast: false
type: Reaction
is: SBO:0000185
product: MODEL1310110045#

metaR RE1845X
product: MODEL1310110045#
is: SBO:0000176
modifier: MODEL1310110045#
kinetic law: MODEL1310110045#
name: RE1845
fast: false
reversible: true
notes: GENE_ASSOCIATION: (570.1) SUBSYSTEM: Bile acid synthesis EC Number: 2.3.1.65 Confidence Level: 0 AUTHORS: PMID:11980911 NOTES:IT - removed 1 h[c] from compEHMN reaction as they were not necessary
is version of: http://identifiers.org/ec-code/2.3.1.65
is described by: ECO:0000000
reactant: MODEL1310110045#
type: Reaction

MODEL1310110045
species: metaM dgmp m
reaction: metaR BILIRUBtr
species: metaM 6pgl r
reaction: metaR EX gal LPAREN e RPAREN
reaction: metaR S6TASE22ly
species: metaM CE5791 e
species: metaM CE0233 c
reaction: metaR NDP3ex
species: metaM pi m
reaction: metaR PNTK
reaction: metaR EX txa2 LPAREN e RPAREN
species: metaM leuktrF4 e
species: metaM dtdp c
species: metaM dgdp c
reaction: metaR r2408
species: metaM h2o2 e
species: metaM ala B c
reaction: metaR DM Asn X Ser Thr ly
reaction: metaR r1109
reaction: metaR r0812
reaction: metaR r1464
reaction: metaR CYTK7n
reaction: metaR PUNP3
reaction: metaR NACDe
reaction: metaR ME1m
reaction: metaR PGMT
reaction: metaR r0734
species: metaM glcur e
reaction: metaR OLEICFATPtc
species: metaM 2amac c
reaction: metaR FAOXC102C103m
species: metaM HC02175 c
species: metaM HC02192 e
species: metaM dcsptn1crn m
reaction: metaR LEUTA
reaction: metaR DESAT22 1p
reaction: metaR RDH3
reaction: metaR ORNt4m
species: metaM nad m
species: metaM HC02192 c
species: metaM dcholcoa r
reaction: metaR r2330
species: metaM dcamp c
reaction: metaR RE0935E
reaction: metaR r2132
reaction: metaR GLYPHEPEPT1tc
reaction: metaR r1636
species: metaM ksii core2 deg5 l
species: metaM utp c
reaction: metaR r0926
species: metaM s2l2fn2m2masn g
species: metaM mmcoa S m
species: metaM 3hpp m
reaction: metaR RE1517M
reaction: metaR r2347
reaction: metaR GLYCtm
reaction: metaR r2328
reaction: metaR SGALSIDEtg
species: metaM cs c l
species: metaM C02528 r
reaction: metaR TYRCBOX
reaction: metaR r0672
reaction: metaR r1644
reaction: metaR EX dtmp LPAREN e RPAREN
species: metaM CE2422 m
species: metaM Rtotal3coa c
species: metaM lnlnca r
reaction: metaR EX cyan LPAREN e RPAREN
reaction: metaR r0390
reaction: metaR BTNtn
reaction: metaR PROSTGE1t
species: metaM 4nphsf e
reaction: metaR EX prostgf2 LPAREN e RPAREN
species: metaM crn x
species: metaM gln L c
reaction: metaR NDPK1m
species: metaM C05957 r
reaction: metaR r0787
reaction: metaR OMHPALTD
reaction: metaR G14T2g

http://identifiers.org/biomodels.db/MODEL1310110045#_c99bf5ab_f306_45af_a948_621d63075f81
is: B3KT70
has only substance units: false
initial amount: NaN
boundary condition: true
initial concentration: NaN
is encoded by: hsa:80201
type: Species
name: HKDC1
constant: false
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110045#_61e63adf_ad7c_46d2_9fe7_806b869ceb2b
is encoded by: hsa:240
initial amount: NaN
has only substance units: false
name: ALOX5
boundary condition: true
initial concentration: NaN
is: P09917
constant: false
is: SBO:0000252
type: Species

metaM 3hpcoa m
boundary condition: false
initial concentration: 1.0
type: Species
is: CHEBI:58528
name: 3-hydroxypropanoyl-CoA(4-)
notes: FORMULA: C24H36N7O18P3S CHARGE: -4 INCHI: InChI=1S/C24H40N7O18P3S/c1-24(2,19(36)22(37)27-5-3-14(33)26-6-8-53-15(34)4-7-32)10-46-52(43,44)49-51(41,42)45-9-13-18(48-50(38,39)40)17(35)23(47-13)31-12-30-16-20(25)28-11-29-21(16)31/h11-13,17-19,23,32,35-36H,3-10H2,1-2H3,(H,26,33)(H,27,37)(H,41,42)(H,43,44)(H2,25,28,29)(H2,38,39,40)/p-4/t13-,17-,18-,19+,23-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01557 EHMN_ABBREVIATION: C05668
is: HMDB06807
is: SBO:0000247
constant: false
initial amount: NaN
has only substance units: false

metaR SPC HSt
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:12069827 NOTES:
kinetic law: MODEL1310110045#
type: Reaction
reactant: MODEL1310110045#
product: MODEL1310110045#
fast: false
is described by: ECO:0000000
name: sphingosylphosphorylcholine transport (diffusion)
reversible: true
is: SBO:0000185

metaM akg m
initial concentration: 1.0
is: CHEBI:16810
boundary condition: false
constant: false
notes: FORMULA: C5H4O5 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00035 EHMN_ABBREVIATION: C00026
is: C00026
type: Species
name: 2-Oxoglutarate
initial amount: NaN
is: HMDB00208
is: SBO:0000247
has only substance units: false

metaM utp n
initial concentration: 1.0
notes: FORMULA: C9H11N2O15P3 CHARGE: -4 INCHI: InChI=1S/C9H15N2O15P3/c12-5-1-2-11(9(15)10-5)8-7(14)6(13)4(24-8)3-23-28(19,20)26-29(21,22)25-27(16,17)18/h1-2,4,6-8,13-14H,3H2,(H,19,20)(H,21,22)(H,10,12,15)(H2,16,17,18)/p-4/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00077 EHMN_ABBREVIATION: C00075
has only substance units: false
boundary condition: false
name: UTP(4-)
type: Species
initial amount: NaN
constant: false
is: SBO:0000247
is: CHEBI:46398
is: HMDB00285

metaR ATPH1e
is version of: http://identifiers.org/ec-code/3.6.1.5
is version of: http://identifiers.org/ec-code/3.6.1.6
kinetic law: MODEL1310110045#
reversible: false
is described by: ECO:0000269
is: SBO:0000176
modifier: MODEL1310110045#
name: ATP diphosphohydrolase
type: Reaction
product: MODEL1310110045#
notes: GENE_ASSOCIATION: (954.1) or (954.2) or (953.1) or (956.1) or (955.1) or (957.1) SUBSYSTEM: Nucleotide interconversion EC Number: 3.6.1.5 Confidence Level: 4 AUTHORS: PMID:8955160,PMID:9676430 NOTES:IT
reactant: MODEL1310110045#
fast: false

metaR r0236
is version of: http://identifiers.org/ec-code/3.5.1.6
product: MODEL1310110045#
name: 5,6-Dihydrouracil:NAD+ oxidoreductase Pyrimidine metabolism EC:1.3.1.1
type: Reaction
fast: false
reversible: true
modifier: MODEL1310110045#
notes: GENE_ASSOCIATION: (AI640625.1) or (51733.1) SUBSYSTEM: Pyrimidine catabolism EC Number: 1.3.1.1 Confidence Level: 0 AUTHORS: PMID:1260500 NOTES:
kinetic law: MODEL1310110045#
is described by: ECO:0000000
reactant: MODEL1310110045#
is: SBO:0000176

metaR r1613
is: SBO:0000185
product: MODEL1310110045#
is described by: ECO:0000000
type: Reaction
modifier: MODEL1310110045#
reactant: MODEL1310110045#
notes: GENE_ASSOCIATION: (19.1) or (AL038231.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
kinetic law: MODEL1310110045#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
fast: false
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110045#_d8af997e_8f69_4e3f_9fdb_fd1507c95c23
has part: P53597
boundary condition: true
has only substance units: false
constant: false
type: Species
is encoded by: hsa:8801
is: SBO:0000297
is encoded by: hsa:8802
initial amount: NaN
initial concentration: NaN
name: SUCLG2:SUCLG1
has part: Q96I99

metaM Ser Thr g
type: Species
is: HMDB00645
is: CHEBI:58336
initial amount: NaN
has only substance units: false
name: protein-linked serine or threonine residue (O-glycosylation site)
constant: false
initial concentration: 1.0
notes: FORMULA: XH CHARGE: 0
is: SBO:0000247
boundary condition: false

metaM CE4876 r
initial amount: NaN
constant: false
is: CHEBI:57923
type: Species
boundary condition: false
name: delta12-Prostaglandin J2
has only substance units: false
initial concentration: 1.0
notes: FORMULA: C20H29O4 CHARGE: -1 INCHI: InChI=1/C20H30O4/c1-2-3-6-10-17(21)13-14-18-16(12-15-19(18)22)9-7-4-5-8-11-20(23)24/h4,7,12,14-17,21H,2-3,5-6,8-11,13H2,1H3,(H,23,24)/p-1/b7-4-,18-14+/t16-,17-/m0/s1 EHMN_ABBREVIATION: CE4876
is: SBO:0000247

metaM aacoa m
name: acetoacetyl-CoA(4-)
is: CHEBI:57286
type: Species
is: HMDB01484
initial amount: NaN
has only substance units: false
constant: false
initial concentration: 1.0
boundary condition: false
notes: FORMULA: C25H36N7O18P3S CHARGE: -4 INCHI: InChI=1S/C25H40N7O18P3S/c1-13(33)8-16(35)54-7-6-27-15(34)4-5-28-23(38)20(37)25(2,3)10-47-53(44,45)50-52(42,43)46-9-14-19(49-51(39,40)41)18(36)24(48-14)32-12-31-17-21(26)29-11-30-22(17)32/h11-12,14,18-20,24,36-37H,4-10H2,1-3H3,(H,27,34)(H,28,38)(H,42,43)(H,44,45)(H2,26,29,30)(H2,39,40,41)/p-4/t14-,18-,19-,20+,24-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00282 EHMN_ABBREVIATION: C00332
is: SBO:0000247

metaR EX abt LPAREN e RPAREN
kinetic law: MODEL1310110045#
reactant: MODEL1310110045#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: L-Arabinitol exchange
type: Reaction

metaR r1828
is described by: ECO:0000000
fast: false
reversible: false
modifier: MODEL1310110045#
kinetic law: MODEL1310110045#
name: Y+LAT2 Utilized transport
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reactant: MODEL1310110045#
product: MODEL1310110045#
type: Reaction
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110045#_5195affe_c00e_44aa_ab4c_00f8c462af02
is: SBO:0000252
constant: false
boundary condition: true
initial concentration: NaN
initial amount: NaN
has only substance units: false
is encoded by: hsa:8704
type: Species
name: B4GALT2

metaR ACGAMtly
is: SBO:0000185
type: Reaction
name: N-acetyl-glucosamine lysosomal efflux
reactant: MODEL1310110045#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 2 AUTHORS: PMID:2784441,PMID:3753439 NOTES:NCD
reversible: false
product: MODEL1310110045#
fast: false
kinetic law: MODEL1310110045#

metaR r0885
fast: false
modifier: MODEL1310110045#
reactant: MODEL1310110045#
kinetic law: MODEL1310110045#
notes: GENE_ASSOCIATION: (AA526438.1) or (H17063.1) or (51102.1) or (55825.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:15845418,PMID:16600197,PMID:9639574 NOTES:
is: SBO:0000185
name: Mitochondrial Carrier (MC) TCDB:2.A.29.2.7
reversible: true
product: MODEL1310110045#
type: Reaction
is version of: http://identifiers.org/ec-code/1.3.1.38
is described by: ECO:0000000

metaM nad r
boundary condition: false
is: CHEBI:57540
name: NAD(1-)
notes: FORMULA: C21H26N7O14P2 CHARGE: -1 INCHI: InChI=1S/C21H27N7O14P2/c22-17-12-19(25-7-24-17)28(8-26-12)21-16(32)14(30)11(41-21)6-39-44(36,37)42-43(34,35)38-5-10-13(29)15(31)20(40-10)27-3-1-2-9(4-27)18(23)33/h1-4,7-8,10-11,13-16,20-21,29-32H,5-6H2,(H5-,22,23,24,25,33,34,35,36,37)/p-1/t10-,11-,13-,14-,15-,16-,20-,21-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00013 EHMN_ABBREVIATION: C00003
initial amount: NaN
constant: false
is: SBO:0000247
has only substance units: false
is: HMDB00902
initial concentration: 1.0
type: Species

metaR r1614
modifier: MODEL1310110045#
notes: GENE_ASSOCIATION: (19.1) or (AL038231.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
kinetic law: MODEL1310110045#
is described by: ECO:0000000
type: Reaction
product: MODEL1310110045#
is: SBO:0000185
fast: false
reversible: true
reactant: MODEL1310110045#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1

metaR LEULEUPEPT1tc
kinetic law: MODEL1310110045#
product: MODEL1310110045#
reactant: MODEL1310110045#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of Leucylleucine by the apical PEPT1 amino acid transporters across the brush border cells of the enterocytes of the intestine and renal cells
type: Reaction

metaR ACOAD1fm
type: Reaction
product: MODEL1310110045#
fast: false
reactant: MODEL1310110045#
is version of: http://identifiers.org/ec-code/1.3.99.3
name: acyl-CoA dehydrogenase (butanoyl-CoA), mitochondrial
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (80724.1) or (36.1) or (35.1) or (34.1) or (84129.1) or (27034.1) or (28976.1) SUBSYSTEM: Butanoate metabolism EC Number: 1.3.99.2 Confidence Level: 4 AUTHORS: PMID:2565344 NOTES:Assume NAD/NADH as acceptors Lumped long-chain acyl-CoA dehydrogenase (EC 1.3.99.13) This reaction is therefore equilivalent to trans-2-enoyl-CoA reductase (NAD) (EC 1.3.1.44)
modifier: MODEL1310110045#
kinetic law: MODEL1310110045#
reversible: false
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.3.8.1

http://identifiers.org/biomodels.db/MODEL1310110045#_82f707a7_1e97_41e2_b3d4_72f8e7bb40e1
has only substance units: false
is: P56556
is: SBO:0000252
type: Species
is encoded by: hsa:4700
initial concentration: NaN
initial amount: NaN
boundary condition: true
name: NDUFA6
constant: false

metaR EX asp D LPAREN e RPAREN
kinetic law: MODEL1310110045#
reactant: MODEL1310110045#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: D-Aspartate exchange
type: Reaction

metaM gtp e
notes: FORMULA: C10H12N5O14P3 CHARGE: -4 INCHI: InChI=1S/C10H16N5O14P3/c11-10-13-7-4(8(18)14-10)12-2-15(7)9-6(17)5(16)3(27-9)1-26-31(22,23)29-32(24,25)28-30(19,20)21/h2-3,5-6,9,16-17H,1H2,(H,22,23)(H,24,25)(H2,19,20,21)(H3,11,13,14,18)/p-4/t3-,5-,6-,9-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00051 EHMN_ABBREVIATION: C00044
boundary condition: false
initial amount: NaN
initial concentration: 1.0
is: CHEBI:37565
constant: false
is: HMDB01273
has only substance units: false
is: SBO:0000247
type: Species
name: GTP(4-)

metaM cala c
name: N-carbamoyl-beta-alaninate
has only substance units: false
is: HMDB00026
boundary condition: false
notes: FORMULA: C4H7N2O3 CHARGE: -1 INCHI: InChI=1S/C4H8N2O3/c5-4(9)6-2-1-3(7)8/h1-2H2,(H,7,8)(H3,5,6,9)/p-1 HEPATONET_1.0_ABBREVIATION: HC00975 EHMN_ABBREVIATION: C02642
type: Species
initial concentration: 1.0
is: SBO:0000247
is: CHEBI:11892
constant: false
initial amount: NaN

metaM glyald c
notes: FORMULA: C3H6O3 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00436 EHMN_ABBREVIATION: C00577
name: D-Glyceraldehyde
type: Species
has only substance units: false
initial amount: NaN
initial concentration: 1.0
is: SBO:0000247
boundary condition: false
is: HMDB01051
constant: false
is: C00577
is: CHEBI:17378

http://identifiers.org/biomodels.db/MODEL1310110045#_d17dab42_195b_475d_b9b0_72634cc12522
is: SBO:0000252
constant: false
has only substance units: false
initial concentration: NaN
boundary condition: true
name: _AA278423_1_c
initial amount: NaN
type: Species
is encoded by: hsa:AA278423

metaR MMCDm
reactant: MODEL1310110045#
type: Reaction
reversible: false
is: SBO:0000176
fast: false
is version of: http://identifiers.org/ec-code/4.1.1.9
is described by: ECO:0000212
name: Methylmalonyl-CoA decarboxylase, mitochondrial
notes: GENE_ASSOCIATION: (23417.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 4.1.1.9 Confidence Level: 1 AUTHORS: PMID:12123667,PMID:12955715 NOTES:JLR mitochondrial isoform - NCD
kinetic law: MODEL1310110045#
modifier: MODEL1310110045#
product: MODEL1310110045#

metaM h2o m
is: C00001
initial amount: NaN
initial concentration: 1.0
is: SBO:0000247
is: CHEBI:15377
is: HMDB02111
name: H2O
type: Species
has only substance units: false
notes: FORMULA: H2O CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00011 EHMN_ABBREVIATION: C00001
boundary condition: false
constant: false

metaR r1615
product: MODEL1310110045#
fast: false
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
notes: GENE_ASSOCIATION: (19.1) or (AL038231.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is described by: ECO:0000000
type: Reaction
reactant: MODEL1310110045#
kinetic law: MODEL1310110045#
reversible: true
modifier: MODEL1310110045#
is: SBO:0000185

metaR UMPK7n
modifier: MODEL1310110045#
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
fast: false
reactant: MODEL1310110045#
type: Reaction
is described by: ECO:0000269
kinetic law: MODEL1310110045#
is version of: http://identifiers.org/ec-code/2.7.4.14
reversible: true
product: MODEL1310110045#
is: SBO:0000176
name: UMP kinase (dGTP),nuclear

metaR RE1804M
name: RE1804
reversible: true
reactant: MODEL1310110045#
fast: false
is: SBO:0000176
type: Reaction
modifier: MODEL1310110045#
kinetic law: MODEL1310110045#
product: MODEL1310110045#
notes: GENE_ASSOCIATION: (1593.1) SUBSYSTEM: Bile acid synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:9660774 NOTES:
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/1.14.13.15

metaR EX C02528 LPAREN e RPAREN
kinetic law: MODEL1310110045#
reactant: MODEL1310110045#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: chenodeoxycholate exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110045#_29379f8c_1717_4f06_8acd_23fd091e3dfe
type: Species
is: SBO:0000252
initial amount: NaN
boundary condition: true
is: Q548A7
initial concentration: NaN
is encoded by: hsa:65010
has only substance units: false
constant: false
name: SLC26A6

metaR GULN3D
is: SBO:0000176
kinetic law: MODEL1310110045#
name: L-gulonate 3-dehydrogenase
type: Reaction
fast: false
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Pentose phosphate pathway EC Number: 1.1.1.45 Confidence Level: 2 AUTHORS: PMID:6821187 NOTES:NCD
reversible: true
product: MODEL1310110045#
reactant: MODEL1310110045#

metaM acgal l
name: N-acetyl-D-galactosamine
initial concentration: 1.0
initial amount: NaN
constant: false
has only substance units: false
is: CHEBI:28037
boundary condition: false
type: Species
is: SBO:0000247
is: HMDB00212
notes: FORMULA: C8H15NO6 CHARGE: 0 INCHI: InChI=1S/C8H15NO6/c1-3(11)9-5-7(13)6(12)4(2-10)15-8(5)14/h4-8,10,12-14H,2H2,1H3,(H,9,11)/t4-,5-,6+,7-,8?/m1/s1 EHMN_ABBREVIATION: C01132

metaR r0451
kinetic law: MODEL1310110045#
is described by: ECO:0000000
reversible: false
product: MODEL1310110045#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 1.2.4.2 Confidence Level: 0 AUTHORS: PMID:10676873 NOTES:
reactant: MODEL1310110045#
fast: false
name: 2-Oxoadipate:lipoamde 2-oxidoreductase(decarboxylating and acceptor-succinylating) Lysine degradation EC:1.2.4.2
is: SBO:0000176

metaR RE1826C
reactant: MODEL1310110045#
name: RE1826
is described by: ECO:0000000
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Bile acid synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:11454857 NOTES:
kinetic law: MODEL1310110045#
fast: false
reversible: false
product: MODEL1310110045#
type: Reaction

metaM CE4872 m
has only substance units: false
notes: FORMULA: C27H46O4 CHARGE: 0 INCHI: InChI=1/C27H46O4/c1-16(15-28)6-5-7-17(2)20-8-9-21-25-22(14-24(31)27(20,21)4)26(3)11-10-19(29)12-18(26)13-23(25)30/h15-25,29-31H,5-14H2,1-4H3/t16u,17-,18-,19+,20-,21-,22-,23+,24-,25-,26?,27-/m1/s1 EHMN_ABBREVIATION: CE4872
is: SBO:0000247
constant: false
boundary condition: false
name: 3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-27-al
initial amount: NaN
is: CHEBI:15748
is: HMDB00127
type: Species
initial concentration: 1.0

metaM h2o n
is: SBO:0000247
notes: FORMULA: H2O CHARGE: 0 INCHI: InChI=1S/H2O/h1H2 HEPATONET_1.0_ABBREVIATION: HC00011 EHMN_ABBREVIATION: C00001
boundary condition: false
type: Species
name: water
has only substance units: false
initial concentration: 1.0
is: CHEBI:15377
constant: false
is: HMDB02111
initial amount: NaN

metaR RAI1
notes: GENE_ASSOCIATION: SUBSYSTEM: Vitamin A metabolism EC Number: 5.2.1.3 Confidence Level: 2 AUTHORS: PMID:1503811 NOTES:IT
is: SBO:0000176
is described by: ECO:0000000
type: Reaction
kinetic law: MODEL1310110045#
reversible: true
reactant: MODEL1310110045#
name: retinal isomerase (11-cis)
product: MODEL1310110045#
fast: false

metaR SUCCt2m
is described by: ECO:0000269
is: SBO:0000185
type: Reaction
name: succinate transport, mitochondrial
product: MODEL1310110045#
reactant: MODEL1310110045#
kinetic law: MODEL1310110045#
notes: GENE_ASSOCIATION: (1468.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172 NOTES:TDV
reversible: true
fast: false
modifier: MODEL1310110045#

metaM gua c
initial concentration: 1.0
notes: FORMULA: C5H5N5O CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00219 EHMN_ABBREVIATION: C00242
is: CHEBI:16235
initial amount: NaN
constant: false
is: SBO:0000247
has only substance units: false
is: HMDB00132
boundary condition: false
type: Species
name: Guanine
is: C00242

metaR r1616
modifier: MODEL1310110045#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
notes: GENE_ASSOCIATION: (19.1) or (AL038231.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
kinetic law: MODEL1310110045#
is described by: ECO:0000000
type: Reaction
is: SBO:0000185
fast: false
product: MODEL1310110045#
reversible: true
reactant: MODEL1310110045#

metaR LCADi D
modifier: MODEL1310110045#
is version of: http://identifiers.org/ec-code/1.2.1.36
name: lactaldehyde dehydrogenase
is described by: ECO:0000304
notes: GENE_ASSOCIATION: (218.1) or (223.1) or (8854.2) or (224.1) or (222.1) or (8854.1) or (221.1) or (216.1) or (8854.3) or (501.1) or (220.1) SUBSYSTEM: Pyruvate metabolism EC Number: 1.2.1.21 Confidence Level: 2 AUTHORS: PMID:15987839,PMID:2296157,PMID:6487654 NOTES:JLR- added irreversible form of LCAD
is: SBO:0000176
type: Reaction
fast: false
reversible: false
kinetic law: MODEL1310110045#
is version of: http://identifiers.org/ec-code/1.2.1.3
product: MODEL1310110045#
is version of: http://identifiers.org/ec-code/1.2.1.5
reactant: MODEL1310110045#

metaR EX 4mop LPAREN e RPAREN
kinetic law: MODEL1310110045#
reactant: MODEL1310110045#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: Exchange of 4-methyl-2-oxopentanoate
type: Reaction

metaR AMPtp
is: SBO:0000185
reversible: true
reactant: MODEL1310110045#
name: AMP transporter, peroxisome
product: MODEL1310110045#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 0 AUTHORS: NOTES:"diffusion" NJ
type: Reaction
is described by: ECO:0000000
kinetic law: MODEL1310110045#

metaM nad x
boundary condition: false
is: http://identifiers.org/pubchem.compound/3305
type: Species
initial amount: NaN
is: CHEBI:57540
name: Nicotinamide adenine dinucleotide
initial concentration: 1.0
is: C00003
constant: false
is: HMDB00902
has only substance units: false
is: SBO:0000247

metaM m8mpdol L r
notes: FORMULA: C1780H2928N20O620P20 CHARGE: -20 INCHI: InChI=1S/C95H162N2O62P2/c1-34(2)13-9-14-35(3)15-10-16-36(4)17-11-18-37(5)19-12-20-38(6)21-22-138-160(132,133)159-161(134,135)158-86-53(97-40(8)108)64(119)77(49(31-106)147-86)150-85-52(96-39(7)107)63(118)78(48(30-105)146-85)151-91-76(131)80(153-94-84(71(126)60(115)46(28-103)144-94)157-95-83(70(125)59(114)47(29-104)145-95)156-90-74(129)67(122)56(111)43(25-100)141-90)62(117)51(149-91)32-136-87-75(130)79(152-93-82(69(124)58(113)45(27-102)143-93)155-89-73(128)66(121)55(110)42(24-99)140-89)61(116)50(148-87)33-137-92-81(68(123)57(112)44(26-101)142-92)154-88-72(127)65(120)54(109)41(23-98)139-88/h13,15,17,19,38,41-95,98-106,109-131H,9-12,14,16,18,20-33H2,1-8H3,(H,96,107)(H,97,108)(H,132,133)(H,134,135)/b35-15+,36-17+,37-19+/t38?,41-,42-,43-,44-,45-,46-,47-,48-,49-,50-,51-,52-,53-,54-,55-,56-,57-,58-,59-,60-,61-,62-,63-,64-,65+,66+,67+,68+,69+,70+,71+,72+,73+,74+,75+,76+,77-,78-,79+,80+,81+,82+,83+,84+,85+,86-,87+,88-,89-,90-,91+,92+,93-,94-,95-/m1/s1 EHMN_ABBREVIATION: C05868
name: (alpha-D-Mannosyl)8-beta-D-mannosyl-diacetylchitobiosyldiphosphodolichol, human liver homolog
boundary condition: false
has only substance units: false
is: SBO:0000247
is: CHEBI:59093
initial amount: NaN
initial concentration: 1.0
constant: false
type: Species

metaR EX tchola LPAREN e RPAREN
kinetic law: MODEL1310110045#
reactant: MODEL1310110045#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Taurocholic acid exchange
type: Reaction

metaM HC01444 e
name: Galactosylglycerol
type: Species
is: SBO:0000247
is: CHEBI:15754
notes: FORMULA: C9H18O8 CHARGE: 0 INCHI: InChI=1S/C9H18O8/c10-1-4(12)3-16-9-8(15)7(14)6(13)5(2-11)17-9/h4-15H,1-3H2/t4-,5-,6+,7+,8-,9-/m1/s1 EHMN_ABBREVIATION: C05401
initial amount: NaN
initial concentration: 1.0
has only substance units: false
constant: false
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110045#_c71fe21f_79a7_4302_a07c_ef9be2564ed0
boundary condition: true
type: Species
initial amount: NaN
name: DPYSL2
is: SBO:0000252
initial concentration: NaN
constant: false
is: B4DR31
has only substance units: false
is encoded by: hsa:1808

http://identifiers.org/biomodels.db/MODEL1310110045#_79e1cfa8_1b8c_4cc0_9b24_7517510f0153
name: PDE3B
type: Species
is: SBO:0000252
boundary condition: true
initial concentration: NaN
has only substance units: false
is: Q13370
initial amount: NaN
constant: false
is encoded by: hsa:5140

metaR r0450
reversible: true
kinetic law: MODEL1310110045#
is described by: ECO:0000000
reactant: MODEL1310110045#
product: MODEL1310110045#
notes: GENE_ASSOCIATION: (AA278423.1) or (48.1) or (50.1) SUBSYSTEM: Lysine metabolism EC Number: 2.6.1.39 Confidence Level: 0 AUTHORS: PMID:8087205 NOTES:
name: L-2-Aminoadipate:2-oxoglutarate aminotransferase Lysine biosynthesis / Lysine degradation EC:2.6.1.39
modifier: MODEL1310110045#
type: Reaction
is version of: http://identifiers.org/ec-code/4.2.1.3
fast: false
is: SBO:0000176

metaR r2139
reversible: true
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.14
type: Reaction
fast: false
is described by: ECO:0000000
modifier: MODEL1310110045#
product: MODEL1310110045#
reactant: MODEL1310110045#
kinetic law: MODEL1310110045#
is: SBO:0000185

metaM 2amac c
initial concentration: 1.0
is: HMDB03609
is: CHEBI:17123
notes: FORMULA: C3H5NO2 CHARGE: 0 INCHI: InChI=1S/C3H5NO2/c1-2(4)3(5)6/h1,4H2,(H,5,6) HEPATONET_1.0_ABBREVIATION: HC00906 EHMN_ABBREVIATION: C02218
type: Species
boundary condition: false
name: 2-aminoacrylic acid
is: SBO:0000247
constant: false
has only substance units: false
initial amount: NaN

metaR r1617
product: MODEL1310110045#
fast: false
is described by: ECO:0000000
type: Reaction
reactant: MODEL1310110045#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
notes: GENE_ASSOCIATION: (19.1) or (AL038231.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
kinetic law: MODEL1310110045#
reversible: true
is: SBO:0000185
modifier: MODEL1310110045#

metaR DCSPTN1CRNt
reversible: false
is: SBO:0000185
fast: false
kinetic law: MODEL1310110045#
product: MODEL1310110045#
type: Reaction
name: transport into the mitochondria (carnitine)
reactant: MODEL1310110045#
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (788.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: NOTES:NJ
modifier: MODEL1310110045#

metaR SERDGLYexR
notes: GENE_ASSOCIATION: (56301.1) and (6520.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10734121,PMID:10863037,PMID:14770310 NOTES:
name: D-Serine/Glycine reversible exchange
reactant: MODEL1310110045#
type: Reaction
modifier: MODEL1310110045#
reversible: true
fast: false
kinetic law: MODEL1310110045#
is described by: ECO:0000304
is: SBO:0000185
product: MODEL1310110045#

metaM ditp c
initial concentration: 1.0
is: HMDB03537
constant: false
has only substance units: false
initial amount: NaN
name: dITP(4-)
is: SBO:0000247
notes: FORMULA: C10H11N4O13P3 CHARGE: -4 INCHI: InChI=1S/C10H15N4O13P3/c15-5-1-7(14-4-13-8-9(14)11-3-12-10(8)16)25-6(5)2-24-29(20,21)27-30(22,23)26-28(17,18)19/h3-7,15H,1-2H2,(H,20,21)(H,22,23)(H,11,12,16)(H2,17,18,19)/p-4/t5-,6+,7+/m0/s1 EHMN_ABBREVIATION: C01345
type: Species
boundary condition: false
is: CHEBI:61382

metaM cys L e
type: Species
constant: false
is: HMDB00574
initial concentration: 1.0
name: L-cysteine
has only substance units: false
is: SBO:0000247
initial amount: NaN
is: CHEBI:17561
notes: FORMULA: C3H7NO2S CHARGE: 0 INCHI: InChI=1S/C3H7NO2S/c4-2(1-7)3(5)6/h2,7H,1,4H2,(H,5,6)/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00099
boundary condition: false

metaR GLCURtly
type: Reaction
notes: GENE_ASSOCIATION: (26503.1) SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 4 AUTHORS: PMID:10581036,PMID:2768261 NOTES:H symport into lysososome. See PMID: 2768261 and PMID: 10581036 ( for human evidence). Sialic acid storage disorders (due to transporter mutations) require import and export e.g. PMID: 2768266 NJ renamed from GLCURlt to GLCURtly - NCD
name: glucuronate transport into lysososme
fast: false
kinetic law: MODEL1310110045#
modifier: MODEL1310110045#
is described by: ECO:0000269
is: SBO:0000185
reactant: MODEL1310110045#
product: MODEL1310110045#
reversible: true

metaM mal L m
is: CHEBI:15589
initial amount: NaN
initial concentration: 1.0
name: (S)-malate(2-)
is: SBO:0000247
notes: FORMULA: C4H4O5 CHARGE: -2 INCHI: InChI=1S/C4H6O5/c5-2(4(8)9)1-3(6)7/h2,5H,1H2,(H,6,7)(H,8,9)/p-2/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00146
has only substance units: false
constant: false
is: HMDB00156
boundary condition: false
type: Species

metaR RE3003M
modifier: MODEL1310110045#
is version of: http://identifiers.org/ec-code/1.1.1.35
reactant: MODEL1310110045#
reversible: true
fast: false
is version of: http://identifiers.org/ec-code/5.3.3.8
kinetic law: MODEL1310110045#
notes: GENE_ASSOCIATION: (1632.1) or (10455.1) or (1962.1) SUBSYSTEM: Fatty acid oxidation EC Number: 5.3.3.8 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:7775433 NOTES:
product: MODEL1310110045#
is: SBO:0000176
is described by: ECO:0000000
name: RE3003
type: Reaction

metaR NACHEXA20ly
type: Reaction
is: SBO:0000176
product: MODEL1310110045#
is version of: http://identifiers.org/ec-code/3.2.1.52
name: beta-N-acetylhexosaminidase A, lysosomal
notes: GENE_ASSOCIATION: (3073.1) or (3073.1 and 3074.1) SUBSYSTEM: Keratan sulfate degradation EC Number: Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12706724,PMID:8993162 NOTES:Note that this reaction is specific to beta-N-acetylhexosaminidase A and cannot be catalyzed by beta-N-acetylhexosaminidase B (or presumably beta-N-acetylhexosaminidase S). This is also a lumped reaction, representing the cleavage of GalNAc4S or GalNAc6S and N-acetylgalactosamine 4-sulfatase or 6-sulfatase. NCD
kinetic law: MODEL1310110045#
reversible: false
fast: false
reactant: MODEL1310110045#
is described by: ECO:0000000
modifier: MODEL1310110045#

metaM C05965 e
has only substance units: false
is: CHEBI:57444
notes: FORMULA: C20H31O4 CHARGE: -1 INCHI: InChI=1S/C20H32O4/c1-2-3-4-5-10-13-16-19(24-23)17-14-11-8-6-7-9-12-15-18-20(21)22/h7-11,13-14,17,19,23H,2-6,12,15-16,18H2,1H3,(H,21,22)/p-1/b9-7-,11-8-,13-10-,17-14+/t19-/m0/s1 EHMN_ABBREVIATION: C05965
type: Species
initial amount: NaN
initial concentration: 1.0
is: SBO:0000247
constant: false
is: HMDB04243
name: 12(S)-HPETE(1-)
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110045#_1afcdd66_a34f_4c7a_a24f_0d5013a382be
initial concentration: NaN
boundary condition: true
initial amount: NaN
type: Species
is encoded by: hsa:250
is: P05187
name: ALPP
constant: false
has only substance units: false
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110045#_01e61e6c_c80b_45c2_8c34_8ef568e4d9b4
initial concentration: NaN
is encoded by: hsa:8560
is: SBO:0000252
initial amount: NaN
boundary condition: true
has only substance units: false
type: Species
name: DEGS1
constant: false

metaM Ser Thr l
name: protein-linked serine or threonine residue (O-glycosylation site)
is: HMDB00224
has only substance units: false
type: Species
is: SBO:0000247
is: CHEBI:58190
initial amount: NaN
boundary condition: false
constant: false
notes: FORMULA: XH CHARGE: 0
initial concentration: 1.0

metaM C02470 c
has only substance units: false
is: HMDB00881
boundary condition: false
initial amount: NaN
type: Species
is: http://identifiers.org/pubchem.compound/5485
is: C02470
notes: FORMULA: C10H6NO4 CHARGE: -1 INCHI: InChI=1/C10H7NO4/c12-7-3-1-2-5-8(13)4-6(10(14)15)11-9(5)7/h1-4,12H,(H,11,13)(H,14,15) HEPATONET_1.0_ABBREVIATION: HC00945 EHMN_ABBREVIATION: C02470
constant: false
name: Xanthurenic acid
is: SBO:0000247
initial concentration: 1.0

metaR GASNASE3ly
is version of: http://identifiers.org/ec-code/3.5.1.26
name: glycosylasparaginase, lysosomal
is described by: ECO:0000000
product: MODEL1310110045#
reactant: MODEL1310110045#
kinetic law: MODEL1310110045#
type: Reaction
fast: false
is: SBO:0000176
reversible: false
modifier: MODEL1310110045#
notes: GENE_ASSOCIATION: (175.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.5.1.26 Confidence Level: 4 AUTHORS: PMID:1703489,PMID:2401370,PMID:8002961 NOTES:NCD

http://identifiers.org/biomodels.db/MODEL1310110045#_e61d761c_7097_45fb_a460_f0dd1f42ad0a
is: SBO:0000252
boundary condition: true
initial amount: NaN
name: SLC27A2
initial concentration: NaN
has only substance units: false
is: O14975
is encoded by: hsa:11001
type: Species
constant: false

metaR r1618
is described by: ECO:0000000
type: Reaction
is: SBO:0000185
fast: false
notes: GENE_ASSOCIATION: (19.1) or (AL038231.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
kinetic law: MODEL1310110045#
product: MODEL1310110045#
reversible: true
modifier: MODEL1310110045#
reactant: MODEL1310110045#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1

metaR CYTK2n
kinetic law: MODEL1310110045#
is version of: http://identifiers.org/ec-code/2.7.4.14
reversible: true
reactant: MODEL1310110045#
product: MODEL1310110045#
name: cytidylate kinase (dCMP),nuclear
type: Reaction
fast: false
modifier: MODEL1310110045#
is: SBO:0000176
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:

metaR GMAND
notes: GENE_ASSOCIATION: (2762.1) SUBSYSTEM: Fructose and mannose metabolism EC Number: 4.2.1.47 Confidence Level: 0 AUTHORS: NOTES:JLR
name: GDP-D-mannose dehydratase
fast: false
type: Reaction
reversible: false
reactant: MODEL1310110045#
is described by: ECO:0000000
kinetic law: MODEL1310110045#
modifier: MODEL1310110045#
product: MODEL1310110045#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/4.2.1.47

http://identifiers.org/biomodels.db/MODEL1310110045#_5b0b072a_3ead_4d39_ac4d_35e106756b56
has only substance units: false
boundary condition: true
type: Species
name: NDUFA9
is: SBO:0000252
initial amount: NaN
constant: false
is: Q16795
initial concentration: NaN
is encoded by: hsa:4704

metaM xol27oh r
name: 26-hydroxycholesterol
is: SBO:0000247
boundary condition: false
is: CHEBI:17703
constant: false
initial concentration: 1.0
type: Species
initial amount: NaN
has only substance units: false
notes: FORMULA: C27H46O2 CHARGE: 0 INCHI: InChI=1S/C27H46O2/c1-18(17-28)6-5-7-19(2)23-10-11-24-22-9-8-20-16-21(29)12-14-26(20,3)25(22)13-15-27(23,24)4/h8,18-19,21-25,28-29H,5-7,9-17H2,1-4H3/t18?,19-,21+,22+,23-,24+,25+,26+,27-/m1/s1 EHMN_ABBREVIATION: C06340
is: HMDB02103

metaM imp e
constant: false
type: Species
notes: FORMULA: C10H11N4O8P CHARGE: -2 INCHI: InChI=1S/C10H13N4O8P/c15-6-4(1-21-23(18,19)20)22-10(7(6)16)14-3-13-5-8(14)11-2-12-9(5)17/h2-4,6-7,10,15-16H,1H2,(H,11,12,17)(H2,18,19,20)/p-2/t4-,6-,7-,10-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00128 EHMN_ABBREVIATION: C00130
is: SBO:0000247
is: CHEBI:58053
boundary condition: false
initial amount: NaN
has only substance units: false
name: IMP(2-)
initial concentration: 1.0
is: HMDB00175

http://identifiers.org/biomodels.db/MODEL1310110045#_4f305199_b747_4c81_aba8_0d01711ca8bd
boundary condition: true
name: MTHFS
type: Species
is: P49914
is: SBO:0000252
constant: false
is encoded by: hsa:10588
initial concentration: NaN
has only substance units: false
initial amount: NaN

metaM HC01397 m
initial concentration: 1.0
has only substance units: false
notes: FORMULA: C37H62N7O18P3S CHARGE: -4 INCHI: InChI=1S/C37H66N7O18P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-25(45)20-28(47)66-19-18-39-27(46)16-17-40-35(50)32(49)37(2,3)22-59-65(56,57)62-64(54,55)58-21-26-31(61-63(51,52)53)30(48)36(60-26)44-24-43-29-33(38)41-23-42-34(29)44/h23-26,30-32,36,45,48-49H,4-22H2,1-3H3,(H,39,46)(H,40,50)(H,54,55)(H,56,57)(H2,38,41,42)(H2,51,52,53)/t25-,26+,30+,31+,32-,36+/m0/s1 EHMN_ABBREVIATION: C05258
constant: false
boundary condition: false
is: CHEBI:27402
is: SBO:0000247
type: Species
name: (S)-3-Hydroxyhexadecanoyl-CoA
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110045#_ee98a092_5a21_4f0b_999f_5c181ce959eb
is: Q16773
has only substance units: false
name: CCBL1
is encoded by: hsa:883
initial concentration: NaN
constant: false
boundary condition: true
is: SBO:0000252
type: Species
initial amount: NaN

metaR FBA4
fast: false
product: MODEL1310110045#
is: SBO:0000176
reactant: MODEL1310110045#
type: Reaction
modifier: MODEL1310110045#
is described by: ECO:0000269
reversible: true
notes: GENE_ASSOCIATION: (226.2) or (229.1) or (226.3) or (230.1) or (226.1) SUBSYSTEM: Glyoxylate and dicarboxylate metabolism EC Number: 4.1.2.13 Confidence Level: 4 AUTHORS: PMID:2996495,PMID:6284103,PMID:6298387 NOTES:NCD
name: D-Fructose 1-phosphate D-glyceraldehyde-3-phosphate-lyase
is version of: http://identifiers.org/ec-code/4.1.2.13
kinetic law: MODEL1310110045#

metaR S23T2g
modifier: MODEL1310110045#
reversible: false
is version of: http://identifiers.org/ec-code/2.4.99.4
product: MODEL1310110045#
reactant: MODEL1310110045#
kinetic law: MODEL1310110045#
is described by: ECO:0000000
type: Reaction
is: SBO:0000176
fast: false
notes: GENE_ASSOCIATION: (6484.1) or (6482.1) or (6483.1) or (6482.2) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.99.4 Confidence Level: 4 AUTHORS: PMID:10504389,PMID:7901202,PMID:8027041,PMID:8288606,PMID:8920913 NOTES:NCD
name: beta-galactoside alpha-2,3-sialyltransferase (core 2)

http://identifiers.org/biomodels.db/MODEL1310110045#_4b38fb9c_7455_42b5_b97e_59838a2210c6
name: GALNT10
is: Q86SR1
has only substance units: false
boundary condition: true
type: Species
constant: false
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:55568
initial amount: NaN

metaM dhcholestancoa r
initial concentration: 1.0
is: HMDB02159
constant: false
is: SBO:0000247
has only substance units: false
type: Species
initial amount: NaN
notes: FORMULA: C48H76N7O19P3S CHARGE: -4 INCHI: InChI=1S/C48H80N7O19P3S/c1-26(30-10-11-31-36-32(13-16-48(30,31)6)47(5)15-12-29(56)20-28(47)21-33(36)57)8-7-9-27(2)45(62)78-19-18-50-35(58)14-17-51-43(61)40(60)46(3,4)23-71-77(68,69)74-76(66,67)70-22-34-39(73-75(63,64)65)38(59)44(72-34)55-25-54-37-41(49)52-24-53-42(37)55/h24-34,36,38-40,44,56-57,59-60H,7-23H2,1-6H3,(H,50,58)(H,51,61)(H,66,67)(H,68,69)(H2,49,52,53)(H2,63,64,65)/t26-,27?,28+,29-,30-,31+,32+,33-,34-,36+,38-,39-,40+,44-,47+,48-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01332 EHMN_ABBREVIATION: C04644
name: 3alpha,7alpha-Dihydroxy-5beta-cholestanoyl-CoA
boundary condition: false
is: CHEBI:15494

metaR SERGLYexR
modifier: MODEL1310110045#
name: L-Serine/Glycine reversible exchange
kinetic law: MODEL1310110045#
type: Reaction
reversible: true
fast: false
reactant: MODEL1310110045#
is: SBO:0000185
notes: GENE_ASSOCIATION: (56301.1) and (6520.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10734121,PMID:10863037,PMID:14770310 NOTES:
product: MODEL1310110045#
is described by: ECO:0000304

metaR PIter
kinetic law: MODEL1310110045#
reversible: true
name: phosphate transport, endoplasmic reticulum
fast: false
product: MODEL1310110045#
is: SBO:0000185
type: Reaction
reactant: MODEL1310110045#
notes: GENE_ASSOCIATION: (2544.1) SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: PMID:11879177 NOTES:NCD
modifier: MODEL1310110045#
is described by: ECO:0000212

metaR r2344
is: SBO:0000185
reversible: true
fast: false
reactant: MODEL1310110045#
type: Reaction
name: Organic anion transporter 5 Utilized transport
product: MODEL1310110045#
is described by: ECO:0000000
kinetic law: MODEL1310110045#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110045#_a8326243_4aba_4f79_9f4d_fa10f8b6f475
boundary condition: true
name: IDH2
initial concentration: NaN
initial amount: NaN
type: Species
is: P48735
has only substance units: false
is encoded by: hsa:3418
constant: false
is: SBO:0000252

metaM pac c
notes: FORMULA: C8H7O2 CHARGE: -1 INCHI: InChI=1S/C8H8O2/c9-8(10)6-7-4-2-1-3-5-7/h1-5H,6H2,(H,9,10)/p-1 HEPATONET_1.0_ABBREVIATION: HC01781 EHMN_ABBREVIATION: C07086
boundary condition: false
name: phenylacetate
has only substance units: false
is: SBO:0000247
type: Species
initial concentration: 1.0
is: HMDB00209
is: CHEBI:18401
constant: false
initial amount: NaN

metaM 3oddcoa m
is: CHEBI:27868
initial concentration: 1.0
constant: false
name: 3-Oxododecanoyl-CoA
initial amount: NaN
boundary condition: false
has only substance units: false
notes: FORMULA: C33H52N7O18P3S CHARGE: -4 INCHI: InChI=1S/C33H56N7O18P3S/c1-4-5-6-7-8-9-10-11-21(41)16-24(43)62-15-14-35-23(42)12-13-36-31(46)28(45)33(2,3)18-55-61(52,53)58-60(50,51)54-17-22-27(57-59(47,48)49)26(44)32(56-22)40-20-39-25-29(34)37-19-38-30(25)40/h19-20,22,26-28,32,44-45H,4-18H2,1-3H3,(H,35,42)(H,36,46)(H,50,51)(H,52,53)(H2,34,37,38)(H2,47,48,49)/t22-,26-,27-,28+,32-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01402 EHMN_ABBREVIATION: C05263
type: Species
is: SBO:0000247
is: HMDB03937

http://identifiers.org/biomodels.db/MODEL1310110045#_c9a3dd9f_e664_49e1_969c_cedc833ecee9
type: Species
has only substance units: false
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:AI291895
is: SBO:0000252
boundary condition: true
constant: false
name: _AI291895_1_c

http://identifiers.org/biomodels.db/MODEL1310110045#_5c000dd8_c42f_482b_a700_24f8eec94e9c
constant: false
has only substance units: false
name: HMGCLL1
is: SBO:0000252
boundary condition: true
is encoded by: hsa:54511
is: Q9NT06
initial concentration: NaN
initial amount: NaN
type: Species

http://identifiers.org/biomodels.db/MODEL1310110045#_dd63461c_b607_4247_ad62_8c135ac5632a
boundary condition: true
type: Species
has only substance units: false
is: Q15147
is encoded by: hsa:5332
initial concentration: NaN
is: SBO:0000252
constant: false
initial amount: NaN
name: PLCB4

metaM ksi deg29 l
is: HMDB00143
initial concentration: 1.0
type: Species
name: keratan sulfate I, degradation product 29
is: SBO:0000247
boundary condition: false
is: CHEBI:12936
initial amount: NaN
notes: FORMULA: C96H157N6O80S3 CHARGE: -3
constant: false
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110045#_44110315_7504_412d_b17a_86f914f00482
type: Species
is encoded by: hsa:48
constant: false
has only substance units: false
initial amount: NaN
name: ACO1
is: P21399
initial concentration: NaN
boundary condition: true
is: SBO:0000252

metaM trdox c
name: Oxidized thioredoxin
initial concentration: 1.0
has only substance units: false
boundary condition: false
constant: false
is: CHEBI:18191
notes: FORMULA: X CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00290 EHMN_ABBREVIATION: C00343
type: Species
is: SBO:0000247
is: C00343
initial amount: NaN

metaR r0317
is version of: http://identifiers.org/ec-code/2.1.2.10
reversible: true
product: MODEL1310110045#
is: SBO:0000176
type: Reaction
notes: GENE_ASSOCIATION: (AI761708.1) or (275.1) or (1738.1) or (2731.1) SUBSYSTEM: Unassigned EC Number: 4.2.1.4 Confidence Level: 0 AUTHORS: PMID:15263083,PMID:16511074 NOTES:
is version of: http://identifiers.org/ec-code/1.8.1.4
reactant: MODEL1310110045#
is described by: ECO:0000000
fast: false
name: citrate hydro-lyase Citrate cycle (TCA cycle) / Glyoxylate and dicarboxylate metabolism EC:4.2.1.4
is version of: http://identifiers.org/ec-code/1.4.4.2
modifier: MODEL1310110045#
kinetic law: MODEL1310110045#

metaR GLCt1r
reversible: true
is: SBO:0000185
product: MODEL1310110045#
type: Reaction
reactant: MODEL1310110045#
name: glucose transport (uniport)
fast: false
modifier: MODEL1310110045#
notes: GENE_ASSOCIATION: (66035.1) or (6517.1) or (56606.1) or (154091.1) or (6513.1) or (11182.1) or (29988.1) or (6514.1) or (155184.1) or (56606.2) or (144195.1) or (6515.1) or (81031.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10421229,PMID:10821868,PMID:10860667,PMID:10860996,PMID:10970791,PMID:11247674,PMID:11583593,PMID:11592815,PMID:11780753,PMID:11832379,PMID:11882499,PMID:12135767,PMID:12483288,PMID:12504846,PMID:12750891,PMID:12914765,PMID:14739288,PMID:15033637,PMID:1701966,PMID:2182619,PMID:2656669,PMID:3103217,PMID:3170580,PMID:3399500,PMID:3839598,PMID:7926364,PMID:8504756,PMID:9230074,PMID:9770484 NOTES:
is described by: ECO:0000269
kinetic law: MODEL1310110045#

metaM pi c
notes: FORMULA: HO4P CHARGE: -2
initial concentration: 1.0
is: SBO:0000247
is: HMDB00973
is: CHEBI:43474
name: hydrogenphosphate
initial amount: NaN
constant: false
type: Species
has only substance units: false
boundary condition: false
is: C00009

metaM imp c
is: C00130
is: HMDB00175
type: Species
constant: false
boundary condition: false
name: IMP
is: SBO:0000247
has only substance units: false
is: CHEBI:58053
notes: FORMULA: C10H11N4O8P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00128 EHMN_ABBREVIATION: C00130
initial amount: NaN
initial concentration: 1.0

metaR G16MT L
notes: GENE_ASSOCIATION: SUBSYSTEM: N-glycan synthesis EC Number: Confidence Level: 0 AUTHORS: NOTES:
is: SBO:0000176
fast: false
product: MODEL1310110045#
name: Glycolipid 1,6-alpha-D-mannosyltransferase (liver)
reactant: MODEL1310110045#
is described by: ECO:0000000
kinetic law: MODEL1310110045#
reversible: false
type: Reaction

metaR Htx
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 0 AUTHORS: NOTES:diffusion NJ
reactant: MODEL1310110045#
kinetic law: MODEL1310110045#
fast: false
is described by: ECO:0000000
type: Reaction
name: H transporter, peroxisome
is: SBO:0000185
product: MODEL1310110045#

metaM sph1p e
initial amount: NaN
has only substance units: false
is: HMDB01383
name: (2S,3R)-2-azaniumyl-3-hydroxyoctadecyl phosphate
type: Species
notes: FORMULA: C18H39NO5P CHARGE: -1 INCHI: InChI=1S/C18H40NO5P/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-18(20)17(19)16-24-25(21,22)23/h17-18,20H,2-16,19H2,1H3,(H2,21,22,23)/p-1/t17-,18+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00675 EHMN_ABBREVIATION: C01120
constant: false
is: CHEBI:57939
boundary condition: false
initial concentration: 1.0
is: SBO:0000247

metaR FBA2
product: MODEL1310110045#
fast: false
is: SBO:0000176
modifier: MODEL1310110045#
reactant: MODEL1310110045#
type: Reaction
notes: GENE_ASSOCIATION: (226.2) or (226.1) or (226.3) or (229.1) or (230.1) SUBSYSTEM: Fructose and mannose metabolism EC Number: 4.1.2.13 Confidence Level: 2 AUTHORS: NOTES:NCD
reversible: true
is described by: ECO:0000304
name: D-Fructose 1-phosphate D-glyceraldehyde-3-phosphate-lyase
is version of: http://identifiers.org/ec-code/4.1.2.13
kinetic law: MODEL1310110045#

metaM dhap e
type: Species
initial amount: NaN
is: CHEBI:57642
initial concentration: 1.0
notes: FORMULA: C3H5O6P CHARGE: -2 INCHI: InChI=1S/C3H7O6P/c4-1-3(5)2-9-10(6,7)8/h4H,1-2H2,(H2,6,7,8)/p-2 HEPATONET_1.0_ABBREVIATION: HC00109 EHMN_ABBREVIATION: C00111
is: HMDB01473
has only substance units: false
constant: false
name: glycerone phosphate(2-)
is: SBO:0000247
boundary condition: false

metaR S6T10g
kinetic law: MODEL1310110045#
type: Reaction
notes: GENE_ASSOCIATION: (23563.2) or (9435.1) or (23563.1) or (10164.1) or (4166.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: Confidence Level: 4 AUTHORS: PMID:10330415,PMID:10491328,PMID:10913333,PMID:11278593,PMID:12403612,PMID:12855678,PMID:9722682 NOTES:NCD
product: MODEL1310110045#
modifier: MODEL1310110045#
is described by: ECO:0000000
name: galactose/N-acetylglucosamine 6-O-sulfotransferase, Golgi apparatus
reactant: MODEL1310110045#
fast: false
reversible: false
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110045#_51b35a20_31c4_4080_9a53_717820fd7a23
boundary condition: true
type: Species
name: ND3
initial amount: NaN
has only substance units: false
is: P03897
constant: false
is encoded by: hsa:4537
is: SBO:0000252
initial concentration: NaN

metaM gtp m
initial concentration: 1.0
is: CHEBI:37565
has only substance units: false
name: GTP
is: HMDB01273
constant: false
type: Species
initial amount: NaN
notes: FORMULA: C10H12N5O14P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00051 EHMN_ABBREVIATION: C00044
is: C00044
boundary condition: false
is: SBO:0000247

metaR 13DAMPPOX
type: Reaction
reversible: false
is version of: http://identifiers.org/ec-code/1.4.3.21
fast: false
name: 1,3-Diaminopropane:oxygen oxidoreductase (deaminating)
is: SBO:0000176
modifier: MODEL1310110045#
product: MODEL1310110045#
notes: GENE_ASSOCIATION: (8639.1) or (26.1) or (314.2) or (314.1) SUBSYSTEM: beta-Alanine metabolism EC Number: 1.4.3.6 Confidence Level: 1 AUTHORS: PMID:15035803,PMID:8920635,PMID:9653080 NOTES:SAB
is described by: ECO:0000212
reactant: MODEL1310110045#
is version of: http://identifiers.org/ec-code/1.4.3.22
kinetic law: MODEL1310110045#

metaR r0423
modifier: MODEL1310110045#
product: MODEL1310110045#
is: SBO:0000176
type: Reaction
fast: false
is version of: http://identifiers.org/ec-code/1.2.1.3
is described by: ECO:0000000
reversible: true
kinetic law: MODEL1310110045#
notes: GENE_ASSOCIATION: (AA081045.1) or (AI620219.1) or (219.1) or (217.1) or (224.1) or (501.1) or (223.1) or (AU149534.1) or (T83654.1) SUBSYSTEM: Unassigned EC Number: 1.1.1.42 Confidence Level: 0 AUTHORS: PMID:10521434,PMID:16489927,PMID:9866202 NOTES:
reactant: MODEL1310110045#
name: Isocitrate:NADP+ oxidoreductase (decarboxylating) Citrate cycle (TCA cycle) EC:1.1.1.42

metaR r2346
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
kinetic law: MODEL1310110045#
fast: false
reversible: true
reactant: MODEL1310110045#
type: Reaction
is described by: ECO:0000000
product: MODEL1310110045#
name: Organic anion transporter 5 Utilized transport

metaR r2347
reactant: MODEL1310110045#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
type: Reaction
fast: false
is: SBO:0000185
is described by: ECO:0000000
reversible: true
product: MODEL1310110045#
name: Organic anion transporter 5 Utilized transport
kinetic law: MODEL1310110045#

http://identifiers.org/biomodels.db/MODEL1310110045#_8ac8f7ab_0980_4191_87de_09fbc15458af
initial amount: NaN
has only substance units: false
initial concentration: NaN
boundary condition: true
is encoded by: hsa:54677
name: CROT
type: Species
is: SBO:0000252
is: E7EQF2
constant: false

http://identifiers.org/biomodels.db/MODEL1310110045#_98300b17_276d_4e3b_9494_a2423650830b
has only substance units: false
initial concentration: NaN
is encoded by: hsa:3028
name: HSD17B10
constant: false
type: Species
is: SBO:0000252
is: Q99714
initial amount: NaN
boundary condition: true

metaR BILIRUBtr
is described by: ECO:0000000
reactant: MODEL1310110045#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: NOTES:cholesterol precursor, transport by "diffusion" -> actually beleived to be flip-flop mechanism (PMID: 12840657). NJ
product: MODEL1310110045#
name: lipid, flip-flop intracellular transport
fast: false
reversible: true
kinetic law: MODEL1310110045#
type: Reaction
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110045#_3c9a1a0f_e2c5_4e26_af22_6435e1ed20b8
has only substance units: false
constant: false
name: GALNT11
is encoded by: hsa:63917
boundary condition: true
type: Species
initial amount: NaN
initial concentration: NaN
is: B3KWF4
is: SBO:0000252

metaR DOLASNT Ler
name: Dolichyl-diphosphooligosaccharide:protein-L-asparagine oligopolysaccharidotransferase (liver)
is described by: ECO:0000000
type: Reaction
reactant: MODEL1310110045#
notes: GENE_ASSOCIATION: (6185.1 and 1650.1 and 6184.1 and 1603.1) SUBSYSTEM: N-glycan synthesis EC Number: 2.4.1.119 Confidence Level: 0 AUTHORS: NOTES:NCD
fast: false
product: MODEL1310110045#
is: SBO:0000176
modifier: MODEL1310110045#
is version of: http://identifiers.org/ec-code/2.4.1.119
reversible: false
kinetic law: MODEL1310110045#

metaR r0541
reactant: MODEL1310110045#
type: Reaction
modifier: MODEL1310110045#
name: Glutaryl-CoA:(acceptor) 2,3-oxidoreductase (decarboxylating) Fatty acid metabolism EC:1.3.99.7
fast: false
is version of: http://identifiers.org/ec-code/3.6.1.5
reversible: true
notes: GENE_ASSOCIATION: (AV717590.1) or (953.1) or (956.1) or (377841.1) SUBSYSTEM: Tryptophan metabolism EC Number: 1.3.99.7 Confidence Level: 0 AUTHORS: PMID:3081514 NOTES:
product: MODEL1310110045#
is: SBO:0000176
kinetic law: MODEL1310110045#
is described by: ECO:0000000

metaR MI134P4P
type: Reaction
is: SBO:0000176
product: MODEL1310110045#
name: inositol-1,3,4-trisphosphate 4-phosphatase
fast: false
reversible: false
reactant: MODEL1310110045#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Inositol phosphate metabolism EC Number: Confidence Level: 2 AUTHORS: PMID:2906139 NOTES:NCD
kinetic law: MODEL1310110045#

metaR EX adprib LPAREN e RPAREN
kinetic law: MODEL1310110045#
reactant: MODEL1310110045#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: ADPribose exchange
type: Reaction

metaM gtp n
type: Species
notes: FORMULA: C10H12N5O14P3 CHARGE: -4 INCHI: InChI=1S/C10H16N5O14P3/c11-10-13-7-4(8(18)14-10)12-2-15(7)9-6(17)5(16)3(27-9)1-26-31(22,23)29-32(24,25)28-30(19,20)21/h2-3,5-6,9,16-17H,1H2,(H,22,23)(H,24,25)(H2,19,20,21)(H3,11,13,14,18)/p-4/t3-,5-,6-,9-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00051 EHMN_ABBREVIATION: C00044
initial amount: NaN
boundary condition: false
initial concentration: 1.0
is: CHEBI:37565
name: GTP(4-)
is: SBO:0000247
has only substance units: false
is: HMDB01273
constant: false

metaR r0424
is version of: http://identifiers.org/ec-code/1.17.1.4
notes: GENE_ASSOCIATION: (7498.1) SUBSYSTEM: Unassigned EC Number: 1.1.1.42 Confidence Level: 0 AUTHORS: PMID:10521434,PMID:16489927,PMID:9866202 NOTES:
name: Isocitrate:NADP+ oxidoreductase (decarboxylating) Citrate cycle (TCA cycle) EC:1.1.1.42
is: SBO:0000176
type: Reaction
modifier: MODEL1310110045#
reactant: MODEL1310110045#
is described by: ECO:0000000
kinetic law: MODEL1310110045#
reversible: true
fast: false
product: MODEL1310110045#

http://identifiers.org/biomodels.db/MODEL1310110045#_dedc9546_3f3a_414b_8ba2_a5c75d8a8db7
is encoded by: hsa:222
initial concentration: NaN
name: ALDH3B2
has only substance units: false
boundary condition: true
type: Species
constant: false
is: P48448
initial amount: NaN
is: SBO:0000252

metaM acetone e
type: Species
is: HMDB01659
boundary condition: false
is: SBO:0000247
constant: false
initial concentration: 1.0
has only substance units: false
notes: FORMULA: C3H6O CHARGE: 0 INCHI: InChI=1S/C3H6O/c1-3(2)4/h1-2H3 HEPATONET_1.0_ABBREVIATION: HC00193 EHMN_ABBREVIATION: C00207
initial amount: NaN
is: CHEBI:15347
name: acetone

metaR RE3001M
reactant: MODEL1310110045#
product: MODEL1310110045#
is version of: http://identifiers.org/ec-code/1.3.1.34
name: RE3001
type: Reaction
is: SBO:0000176
is described by: ECO:0000000
fast: false
kinetic law: MODEL1310110045#
modifier: MODEL1310110045#
reversible: true
notes: GENE_ASSOCIATION: (1666.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.1.34 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:7775433 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110045#_2455d9ad_9567_48c2_a81a_1c3c8df6935f
name: _AI345944_1_m
initial amount: NaN
is: SBO:0000252
initial concentration: NaN
type: Species
has only substance units: false
is encoded by: hsa:AI345944
constant: false
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110045#_32a29904_decc_4a5a_ade3_5d0070910cd7
constant: false
boundary condition: true
initial concentration: NaN
name: SLC24A4
type: Species
is encoded by: hsa:123041
initial amount: NaN
is: SBO:0000252
has only substance units: false

metaR G14T2g
name: beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase, Golgi
is described by: ECO:0000000
type: Reaction
fast: false
product: MODEL1310110045#
kinetic law: MODEL1310110045#
modifier: MODEL1310110045#
is version of: http://identifiers.org/ec-code/2.4.1.38
is: SBO:0000176
notes: GENE_ASSOCIATION: (8703.1) or (2683.1) or (8704.2) or (8704.1) or (9334.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.38 Confidence Level: 4 AUTHORS: PMID:12512857,PMID:1903938,PMID:3094506,PMID:3144273,PMID:9405390,PMID:9435216 NOTES:Keratan sulfate II biosynthesis NCD
is version of: http://identifiers.org/ec-code/2.4.1.90
reversible: false
reactant: MODEL1310110045#
is version of: http://identifiers.org/ec-code/2.4.1.22

metaR NDPK5
is version of: http://identifiers.org/ec-code/2.7.4.6
reversible: true
is: SBO:0000176
reactant: MODEL1310110045#
name: Nucleoside-diphosphate kinase (ATP:dGDP)
fast: false
kinetic law: MODEL1310110045#
type: Reaction
modifier: MODEL1310110045#
notes: GENE_ASSOCIATION: (4832.1) or (4831.1 and 4830.2) or (10201.1) or (29922.2) or (29922.1) or (4831.1 and 4830.1) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: NOTES:
is described by: ECO:0000269
product: MODEL1310110045#

http://identifiers.org/biomodels.db/MODEL1310110045#_d3572945_9e2e_4b71_a5b9_7962449d4b76
has only substance units: false
type: Species
boundary condition: true
is: SBO:0000252
name: ACSS3
is: Q9H6R3
constant: false
initial amount: NaN
is encoded by: hsa:79611
initial concentration: NaN

metaM crm hs r
has only substance units: false
constant: false
notes: FORMULA: C18H36NO2FULLRCO CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC01990 EHMN_ABBREVIATION: C00195
is: SBO:0000247
initial concentration: 1.0
boundary condition: false
initial amount: NaN
name: N-acylsphingosine
is: CHEBI:52639
type: Species

metaM arachcoa m
is: HMDB04258
notes: FORMULA: C41H70N7O17P3S CHARGE: -4 INCHI: InChI=1S/C41H74N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-32(50)69-25-24-43-31(49)22-23-44-39(53)36(52)41(2,3)27-62-68(59,60)65-67(57,58)61-26-30-35(64-66(54,55)56)34(51)40(63-30)48-29-47-33-37(42)45-28-46-38(33)48/h28-30,34-36,40,51-52H,4-27H2,1-3H3,(H,43,49)(H,44,53)(H,57,58)(H,59,60)(H2,42,45,46)(H2,54,55,56)/t30-,34-,35-,36+,40-/m1/s1 EHMN_ABBREVIATION: C02041
is: CHEBI:15527
constant: false
has only substance units: false
boundary condition: false
name: arachidyl coenzyme A
initial amount: NaN
type: Species
is: SBO:0000247
initial concentration: 1.0

metaR r0655
name: 3-Methylbutanoyl-CoA:(acceptor) 2,3-oxidoreductase Valine, leucine and isoleucine degradation EC:1.3.99.10
product: MODEL1310110045#
is version of: http://identifiers.org/ec-code/1.5.1.2
notes: GENE_ASSOCIATION: (10637.1) or (5831.1) or (29920.1) or (65263.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 1.3.99.10 Confidence Level: 0 AUTHORS: PMID:3597357,PMID:9214289 NOTES:
modifier: MODEL1310110045#
reactant: MODEL1310110045#
fast: false
kinetic law: MODEL1310110045#
is: SBO:0000176
type: Reaction
is described by: ECO:0000000
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110045#_55fc324e_f4ce_452f_bdcd_e2d08cacd480
is encoded by: hsa:23236
initial amount: NaN
name: PLCB1
initial concentration: NaN
constant: false
has only substance units: false
type: Species
is: SBO:0000252
boundary condition: true

metaM 4abutn e
notes: FORMULA: C4H10NO CHARGE: 1 INCHI: InChI=1S/C4H9NO/c5-3-1-2-4-6/h4H,1-3,5H2/p+1 HEPATONET_1.0_ABBREVIATION: HC00428 EHMN_ABBREVIATION: C00555
name: 4-ammoniobutanal
type: Species
has only substance units: false
is: SBO:0000247
initial amount: NaN
constant: false
is: HMDB01080
initial concentration: 1.0
is: CHEBI:58264
boundary condition: false

metaM clpndcoa x
initial amount: NaN
is: http://identifiers.org/pubchem.compound/47205476
is: SBO:0000247
notes: FORMULA: C43H64N7O17P3S CHARGE: -4 INCHI: InChI=1/C43H68N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-34(52)71-27-26-45-33(51)24-25-46-41(55)38(54)43(2,3)29-64-70(61,62)67-69(59,60)63-28-32-37(66-68(56,57)58)36(53)42(65-32)50-31-49-35-39(44)47-30-48-40(35)50/h5-6,8-9,11-12,14-15,17-18,30-32,36-38,42,53-54H,4,7,10,13,16,19-29H2,1-3H3,(H,45,51)(H,46,55)(H,59,60)(H,61,62)(H2,44,47,48)(H2,56,57,58)/p-4/b6-5-,9-8-,12-11-,15-14-,18-17-/t32-,36+,37+,38?,42-/m0/s1
boundary condition: false
is: HMDB06267
is: C16166
constant: false
has only substance units: false
name: clupanodonyl CoA
type: Species
initial concentration: 1.0

metaR NDPK6
is described by: ECO:0000269
product: MODEL1310110045#
name: Nucleoside-diphosphate kinase (ATP:dUDP)
is version of: http://identifiers.org/ec-code/2.7.4.6
type: Reaction
modifier: MODEL1310110045#
reactant: MODEL1310110045#
notes: GENE_ASSOCIATION: (4832.1) or (4831.1 and 4830.1) or (10201.1) or (29922.2) or (29922.1) or (4831.1 and 4830.2) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: NOTES:
fast: false
reversible: true
kinetic law: MODEL1310110045#
is: SBO:0000176

metaM acetone c
has only substance units: false
is: CHEBI:15347
notes: FORMULA: C3H6O CHARGE: 0 INCHI: InChI=1S/C3H6O/c1-3(2)4/h1-2H3 HEPATONET_1.0_ABBREVIATION: HC00193 EHMN_ABBREVIATION: C00207
constant: false
name: acetone
is: HMDB01659
boundary condition: false
initial amount: NaN
is: SBO:0000247
type: Species
initial concentration: 1.0

metaR EX anth LPAREN e RPAREN
kinetic law: MODEL1310110045#
reactant: MODEL1310110045#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: Exchange of anthranilate
type: Reaction

metaM bhb m
is: CHEBI:10983
has only substance units: false
constant: false
name: (R)-3-hydroxybutyrate
boundary condition: false
notes: FORMULA: C4H7O3 CHARGE: -1 INCHI: InChI=1S/C4H8O3/c1-3(5)2-4(6)7/h3,5H,2H2,1H3,(H,6,7)/p-1/t3-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00661 EHMN_ABBREVIATION: C01089
is: SBO:0000247
type: Species
initial amount: NaN
initial concentration: 1.0
is: HMDB00011

http://identifiers.org/biomodels.db/MODEL1310110045#_a5bcb751_757d_4339_9746_abdcad1a6087
is: Q7Z4L0
has only substance units: false
name: COX8C
is encoded by: hsa:341947
initial concentration: NaN
type: Species
is: SBO:0000252
constant: false
initial amount: NaN
boundary condition: true

metaR NDPK7
reversible: true
is described by: ECO:0000269
product: MODEL1310110045#
modifier: MODEL1310110045#
fast: false
notes: GENE_ASSOCIATION: (4832.1) or (4831.1 and 4830.1) or (10201.1) or (29922.2) or (29922.1) or (4831.1 and 4830.2) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: NOTES:
kinetic law: MODEL1310110045#
name: nucleoside-diphosphate kinase (ATP:dCDP)
reactant: MODEL1310110045#
is version of: http://identifiers.org/ec-code/2.7.4.6
type: Reaction
is: SBO:0000176

metaM pi g
initial amount: NaN
name: hydrogenphosphate
initial concentration: 1.0
is: SBO:0000247
is: HMDB00973
notes: FORMULA: HO4P CHARGE: -2 INCHI: InChI=1S/H3O4P/c1-5(2,3)4/h(H3,1,2,3,4)/p-2 HEPATONET_1.0_ABBREVIATION: HC00019 EHMN_ABBREVIATION: C00009
has only substance units: false
boundary condition: false
type: Species
is: CHEBI:43474
constant: false

http://identifiers.org/biomodels.db/MODEL1310110045#_02a25300_b3c7_4f59_8232_afe8e576a55b
name: RHBG
is: Q9H310
initial concentration: NaN
has only substance units: false
constant: false
is: SBO:0000252
boundary condition: true
is encoded by: hsa:57127
initial amount: NaN
type: Species

metaR LDH D
reversible: true
reactant: MODEL1310110045#
type: Reaction
modifier: MODEL1310110045#
name: D-lactate dehydrogenase
is version of: http://identifiers.org/ec-code/1.1.2.4
notes: GENE_ASSOCIATION: (197257.1) or (197257.2) SUBSYSTEM: Pyruvate metabolism EC Number: 1.1.1.28 Confidence Level: 2 AUTHORS: PMID:11955284,PMID:12127981 NOTES:See also LDL_L. D-lactate metabolism measured in rat mitochondria; probably depend on D-LDH activity in matrix plus transport activity across mitochondrial membrane; putative human D-LDH cloned ; D-lactate formed in nanomolar concentrations via the methylglyoxal pathway; D- -hydroxy acid dehydrogenase (EC 1.1.99.6)
fast: false
product: MODEL1310110045#
is described by: ECO:0000304
kinetic law: MODEL1310110045#
is: SBO:0000176

metaM ksii core2 pre7 g
initial amount: NaN
boundary condition: false
notes: FORMULA: C67H108N5O51SX CHARGE: -2
name: keratan sulfate II biosynthesis, precursor 7
type: Species
constant: false
is: SBO:0000247
is: CHEBI:58053
is: C00130
is: HMDB00175
initial concentration: 1.0
has only substance units: false

metaR LEUKTRF4t
reactant: MODEL1310110045#
type: Reaction
is: SBO:0000185
reversible: true
fast: false
kinetic law: MODEL1310110045#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:
product: MODEL1310110045#
name: leukotriene F4 transport

metaM nh4 e
type: Species
is: CHEBI:28938
constant: false
is: SBO:0000247
boundary condition: false
initial concentration: 1.0
is: HMDB00051
initial amount: NaN
has only substance units: false
name: ammonium
notes: FORMULA: H4N CHARGE: 1 INCHI: InChI=1S/H3N/h1H3/p+1 HEPATONET_1.0_ABBREVIATION: HC00765 EHMN_ABBREVIATION: C01342

http://identifiers.org/biomodels.db/MODEL1310110045#_ea9ca9c9_a1c3_4305_a265_a27616ff90fe
name: GCNT1
has only substance units: false
is: Q02742
initial amount: NaN
boundary condition: true
initial concentration: NaN
is: SBO:0000252
type: Species
constant: false
is encoded by: hsa:2650

metaM 3ohdcoa x
is: HMDB06402
initial concentration: 1.0
type: Species
is: CHEBI:57349
is: SBO:0000247
boundary condition: false
constant: false
name: 3-oxopalmitoyl-CoA(4-)
notes: FORMULA: C37H60N7O18P3S CHARGE: -4 INCHI: InChI=1S/C37H64N7O18P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-25(45)20-28(47)66-19-18-39-27(46)16-17-40-35(50)32(49)37(2,3)22-59-65(56,57)62-64(54,55)58-21-26-31(61-63(51,52)53)30(48)36(60-26)44-24-43-29-33(38)41-23-42-34(29)44/h23-24,26,30-32,36,48-49H,4-22H2,1-3H3,(H,39,46)(H,40,50)(H,54,55)(H,56,57)(H2,38,41,42)(H2,51,52,53)/p-4/t26-,30-,31-,32+,36-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01398 EHMN_ABBREVIATION: C05259
initial amount: NaN
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110045#_73599507_ab65_4a0f_bbdd_ff9dd7be6beb
is: SBO:0000252
boundary condition: true
initial amount: NaN
type: Species
has only substance units: false
is: P11169
is encoded by: hsa:6515
name: SLC2A3
constant: false
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110045#_5706b898_017b_4f14_a1e4_2c6cbffef17f
initial amount: NaN
constant: false
is encoded by: hsa:197257
has only substance units: false
boundary condition: true
initial concentration: NaN
name: LDHD
is: SBO:0000252
type: Species

metaR NDPK8
kinetic law: MODEL1310110045#
is described by: ECO:0000269
modifier: MODEL1310110045#
name: Nucleoside-diphosphate kinase (ATP:dADP)
product: MODEL1310110045#
type: Reaction
notes: GENE_ASSOCIATION: (4832.1) or (4831.1 and 4830.1) or (10201.1) or (29922.2) or (29922.1) or (4831.1 and 4830.2) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: NOTES:
is: SBO:0000176
reversible: true
fast: false
reactant: MODEL1310110045#
is version of: http://identifiers.org/ec-code/2.7.4.6

http://identifiers.org/biomodels.db/MODEL1310110045#_83691374_851f_4473_bd1a_f9a354ec3b35
constant: false
is: SBO:0000252
has only substance units: false
is: Q96RV2
boundary condition: true
name: HAS3
is encoded by: hsa:3038
type: Species
initial amount: NaN
initial concentration: NaN

metaM glyc3p c
is: HMDB00126
notes: FORMULA: C3H7O6P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00095 EHMN_ABBREVIATION: C00093
is: SBO:0000247
name: Glycerol 3-phosphate
constant: false
boundary condition: false
has only substance units: false
type: Species
is: CHEBI:57597
initial amount: NaN
initial concentration: 1.0
is: C00093

http://identifiers.org/biomodels.db/MODEL1310110045#_af622095_d7fa_4b18_a60c_419a4545821d
is encoded by: hsa:83549
boundary condition: true
is: Q5JT09
name: UCK1
type: Species
constant: false
is: SBO:0000252
initial amount: NaN
has only substance units: false
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110045#_ca501c43_5c8b_47e5_bf46_8f0965f3c9dd
name: PTGIS
boundary condition: true
has only substance units: false
is: SBO:0000252
constant: false
is: Q16647
initial concentration: NaN
type: Species
initial amount: NaN
is encoded by: hsa:5740

http://identifiers.org/biomodels.db/MODEL1310110045#_5a812c8d_e652_42d2_be92_31f38035796b
has only substance units: false
initial amount: NaN
type: Species
name: BCAT1
constant: false
is: SBO:0000252
initial concentration: NaN
is: P54687
boundary condition: true
is encoded by: hsa:586

http://identifiers.org/biomodels.db/MODEL1310110045#_5b1c0fcb_6821_45b8_9dc2_475025c65211
is: SBO:0000252
initial concentration: NaN
is encoded by: hsa:2678
constant: false
initial amount: NaN
name: GGT1
has only substance units: false
type: Species
is: P19440
boundary condition: true

metaM ksii core2 deg2 l
type: Species
name: keratan sulfate II (core 2-linked), degradation product 2
is: CHEBI:12936
is: HMDB00143
initial amount: NaN
is: SBO:0000247
notes: FORMULA: C70H114N5O56S2X CHARGE: -2
has only substance units: false
constant: false
boundary condition: false
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110045#_757c9cde_e624_47f0_89c3_b19a3194ae4e
is: SBO:0000252
type: Species
has only substance units: false
is encoded by: hsa:7498
name: XDH
is: P47989
initial amount: NaN
constant: false
boundary condition: true
initial concentration: NaN

metaM retinal cis 9 r
boundary condition: false
is: HMDB01358
type: Species
constant: false
is: SBO:0000247
has only substance units: false
initial amount: NaN
initial concentration: 1.0
is: CHEBI:17898
notes: FORMULA: C20H28O CHARGE: 0 INCHI: InChI=1S/C20H28O/c1-16(8-6-9-17(2)13-15-21)11-12-19-18(3)10-7-14-20(19,4)5/h6,8-9,11-13,15H,7,10,14H2,1-5H3/b9-6+,12-11+,16-8+,17-13+ EHMN_ABBREVIATION: CE5575
name: all-trans-retinal

metaM 4abutn c
is: SBO:0000247
is: C00555
is: HMDB01080
constant: false
boundary condition: false
is: CHEBI:58264
notes: FORMULA: C4H10NO CHARGE: 1 HEPATONET_1.0_ABBREVIATION: HC00428 EHMN_ABBREVIATION: C00555
name: 4-Aminobutanal
initial concentration: 1.0
has only substance units: false
initial amount: NaN
type: Species

metaR NDPK9
reversible: true
fast: false
product: MODEL1310110045#
name: nucleoside-diphosphate kinase (ATP:IDP)
reactant: MODEL1310110045#
modifier: MODEL1310110045#
notes: GENE_ASSOCIATION: (4832.1) or (4831.1 and 4830.1) or (10201.1) or (29922.2) or (29922.1) or (4831.1 and 4830.2) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.6 Confidence Level: 4 AUTHORS: NOTES:NCD
type: Reaction
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.7.4.6
is described by: ECO:0000269
kinetic law: MODEL1310110045#

metaR PRISTCOAtx
reactant: MODEL1310110045#
fast: false
is: SBO:0000185
type: Reaction
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 0 AUTHORS: NOTES:Mechanism not known, see PMID 11591435 for justification. NJ
is described by: ECO:0000000
name: pristcoa peroxisomal transport
product: MODEL1310110045#
kinetic law: MODEL1310110045#

metaR r0545
name: Phenylacetaldehyde:NAD+ oxidoreductase Phenylalanine metabolism / Styrene degradation EC:1.2.1.5 EC:1.2.1.39
product: MODEL1310110045#
is version of: http://identifiers.org/ec-code/3.6.1.5
fast: false
is: SBO:0000176
type: Reaction
reversible: true
modifier: MODEL1310110045#
is described by: ECO:0000000
kinetic law: MODEL1310110045#
reactant: MODEL1310110045#
notes: GENE_ASSOCIATION: (AV717590.1) or (953.1) or (956.1) or (377841.1) SUBSYSTEM: Phenylalanine metabolism EC Number: 1.2.1.5 Confidence Level: 0 AUTHORS: PMID:15230339 NOTES:

metaM pi e
constant: false
notes: FORMULA: HO4P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00019 EHMN_ABBREVIATION: C00009
name: hydrogenphosphate
is: C00009
initial amount: NaN
initial concentration: 1.0
has only substance units: false
is: SBO:0000247
is: HMDB00973
boundary condition: false
type: Species
is: CHEBI:43474

http://identifiers.org/biomodels.db/MODEL1310110045#_1058a059_044b_4fae_a962_f66348d57851
name: PPT2
is encoded by: hsa:9374
type: Species
has only substance units: false
constant: false
initial concentration: NaN
boundary condition: true
is: SBO:0000252
initial amount: NaN
is: Q9UMR5

metaM gdpmann c
is: HMDB01163
constant: false
initial amount: NaN
is: SBO:0000247
is: CHEBI:57527
boundary condition: false
notes: FORMULA: C16H23N5O16P2 CHARGE: -2 INCHI: InChI=1S/C16H25N5O16P2/c17-16-19-12-6(13(28)20-16)18-3-21(12)14-10(26)8(24)5(34-14)2-33-38(29,30)37-39(31,32)36-15-11(27)9(25)7(23)4(1-22)35-15/h3-5,7-11,14-15,22-27H,1-2H2,(H,29,30)(H,31,32)(H3,17,19,20,28)/p-2/t4-,5-,7-,8-,9+,10-,11+,14-,15-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00098 EHMN_ABBREVIATION: C00096
initial concentration: 1.0
has only substance units: false
type: Species
name: GDP-alpha-D-mannose(2-)

metaR NDPK1
is described by: ECO:0000134
product: MODEL1310110045#
name: nucleoside-diphosphate kinase (ATP:GDP)
modifier: MODEL1310110045#
fast: false
is: SBO:0000176
reversible: true
kinetic law: MODEL1310110045#
is version of: http://identifiers.org/ec-code/2.7.4.6
notes: GENE_ASSOCIATION: (4832.1) or (10201.1) or (4831.1 and 4830.1) or (29922.2) or (4831.1 and 4830.2) or (29922.1) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: NOTES:
type: Reaction
reactant: MODEL1310110045#

metaR CITtam
notes: GENE_ASSOCIATION: (6576.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172 NOTES:antiport with malate IF
is described by: ECO:0000269
reactant: MODEL1310110045#
modifier: MODEL1310110045#
reversible: true
name: citrate transport, mitochondrial
kinetic law: MODEL1310110045#
product: MODEL1310110045#
is: SBO:0000185
fast: false
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110045#_10cd0754_3c0e_4533_9ee0_6c55ea6e41f2
is: SBO:0000252
is: Q9P212
has only substance units: false
initial amount: NaN
name: PLCE1
initial concentration: NaN
type: Species
constant: false
is encoded by: hsa:51196
boundary condition: true

metaM dgdp c
initial amount: NaN
has only substance units: false
notes: FORMULA: C10H12N5O10P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00305 EHMN_ABBREVIATION: C00361
constant: false
initial concentration: 1.0
is: C00361
name: dGDP
boundary condition: false
is: HMDB00960
is: SBO:0000247
type: Species
is: CHEBI:58595

metaR r0651
type: Reaction
fast: false
reactant: MODEL1310110045#
is version of: http://identifiers.org/ec-code/1.5.1.2
notes: GENE_ASSOCIATION: (10637.1) or (5831.1) or (29920.1) or (65263.1) SUBSYSTEM: Bile acid synthesis EC Number: 6.2.1.7 Confidence Level: 0 AUTHORS: PMID:10749848,PMID:10884298,PMID:15026425,PMID:438652,PMID:6173037 NOTES:
reversible: true
kinetic law: MODEL1310110045#
product: MODEL1310110045#
name: Chenodeoxycholate:CoA ligase (AMP-forming) Bile acid biosynthesis EC:6.2.1.7
is: SBO:0000176
modifier: MODEL1310110045#
is described by: ECO:0000000

metaR MMEm
fast: false
kinetic law: MODEL1310110045#
notes: GENE_ASSOCIATION: (84693.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 5.1.99.1 Confidence Level: 4 AUTHORS: PMID:11481338 NOTES:TDV
product: MODEL1310110045#
type: Reaction
modifier: MODEL1310110045#
is described by: ECO:0000269
reactant: MODEL1310110045#
is: SBO:0000176
name: methylmalonyl-CoA epimerase/racemase
reversible: true
is version of: http://identifiers.org/ec-code/5.1.99.1

metaM nh4 c
is: C01342
has only substance units: false
boundary condition: false
name: Ammonium
is: HMDB00051
is: SBO:0000247
initial concentration: 1.0
initial amount: NaN
type: Species
constant: false
is: CHEBI:28938
notes: FORMULA: H4N CHARGE: 1 HEPATONET_1.0_ABBREVIATION: HC00765 EHMN_ABBREVIATION: C01342

metaR r0002
type: Reaction
is described by: ECO:0000000
name: Active transport
kinetic law: MODEL1310110045#
is: SBO:0000185
reactant: MODEL1310110045#
reversible: true
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:10460205,PMID:1296165,PMID:16288981,PMID:17466261,PMID:2199597,PMID:6219439,PMID:6361812,PMID:8353366 NOTES:
product: MODEL1310110045#

http://identifiers.org/biomodels.db/MODEL1310110045#_f328d27e_73e3_4cbe_a8af_6eb94ce912b7
is: Q9NRD9
name: DUOX1
constant: false
initial concentration: NaN
is: SBO:0000252
has only substance units: false
initial amount: NaN
boundary condition: true
type: Species
is encoded by: hsa:53905

metaM retinal cis 9 c
type: Species
is: HMDB01358
has only substance units: false
constant: false
boundary condition: false
notes: FORMULA: C20H28O CHARGE: 0 INCHI: InChI=1S/C20H28O/c1-16(8-6-9-17(2)13-15-21)11-12-19-18(3)10-7-14-20(19,4)5/h6,8-9,11-13,15H,7,10,14H2,1-5H3/b9-6+,12-11+,16-8+,17-13+ EHMN_ABBREVIATION: CE5575
name: all-trans-retinal
is: SBO:0000247
initial amount: NaN
initial concentration: 1.0
is: CHEBI:17898

metaM retinol 9 cis c
type: Species
initial amount: NaN
is: HMDB06217
initial concentration: 1.0
is: SBO:0000247
is: CHEBI:17336
constant: false
name: 9-cis-retinol
has only substance units: false
notes: FORMULA: C20H30O CHARGE: 0 INCHI: InChI=1S/C20H30O/c1-16(8-6-9-17(2)13-15-21)11-12-19-18(3)10-7-14-20(19,4)5/h6,8-9,11-13,21H,7,10,14-15H2,1-5H3/b9-6+,12-11+,16-8+,17-13+
boundary condition: false

metaR NDPK2
is described by: ECO:0000269
reversible: true
reactant: MODEL1310110045#
name: nucleoside-diphosphate kinase (ATP:UDP)
notes: GENE_ASSOCIATION: (4832.1) or (29922.1) or (4831.1 and 4830.1) or (10201.1) or (4831.1 and 4830.2) or (29922.2) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: NOTES:
product: MODEL1310110045#
fast: false
type: Reaction
kinetic law: MODEL1310110045#
is version of: http://identifiers.org/ec-code/2.7.4.6
modifier: MODEL1310110045#
is: SBO:0000176

metaR r0652
reversible: true
name: trans-Tetradec-2-enoyl-CoA reductase Fatty acid elongation in mitochondria EC:1.3.1.38
notes: GENE_ASSOCIATION: (10637.1) or (5831.1) or (29920.1) or (65263.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.1.38 Confidence Level: 0 AUTHORS: PMID:12654921 NOTES:
fast: false
reactant: MODEL1310110045#
is: SBO:0000176
modifier: MODEL1310110045#
is described by: ECO:0000000
type: Reaction
kinetic law: MODEL1310110045#
product: MODEL1310110045#
is version of: http://identifiers.org/ec-code/1.5.1.2

metaR DESAT20 1
product: MODEL1310110045#
kinetic law: MODEL1310110045#
type: Reaction
is described by: ECO:0000000
fast: false
name: fatty acyl-CoA desaturase (n-C20:3CoA -> n-C20:4CoA)
is: SBO:0000176
modifier: MODEL1310110045#
notes: GENE_ASSOCIATION: (3992.1) SUBSYSTEM: Fatty acid synthesis EC Number: 1.14.19.1 Confidence Level: 4 AUTHORS: NOTES:for homo sapiens, noted to actually be NADH-cyt b5, using NADH at present NJ
reactant: MODEL1310110045#
reversible: false

metaM fol e
constant: false
is: SBO:0000247
name: Folate
notes: FORMULA: C19H18N7O6 CHARGE: -1
is: HMDB00121
has only substance units: false
initial amount: NaN
boundary condition: false
type: Species
initial concentration: 1.0

metaR r0653
is: SBO:0000176
type: Reaction
fast: false
kinetic law: MODEL1310110045#
is described by: ECO:0000000
name: myristoyl-CoA:acetylCoA C-myristoyltransferase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:2.3.1.16
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.16 Confidence Level: 0 AUTHORS: PMID:10706581,PMID:1121274,PMID:1679347,PMID:3194209,PMID:6378901,PMID:8241273 NOTES:
product: MODEL1310110045#
reversible: false
reactant: MODEL1310110045#

metaR FAOXC16080m
product: MODEL1310110045#
is described by: ECO:0000269
is: SBO:0000176
modifier: MODEL1310110045#
is version of: http://identifiers.org/ec-code/1.3.8.1
reversible: false
name: Beta oxidation of long chain fatty acid
reactant: MODEL1310110045#
notes: GENE_ASSOCIATION: (35.1) or (34.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.74 Confidence Level: 4 AUTHORS: NOTES:_4 rounds of beta ox c16:0 -> c8:0, 4 step FAO lumped for 2 rounds also includes EC 1.1.1.35, 1.1.1.211, 1.3.3.6, 4.2.1.17, 4.2.1.74 NJ
kinetic law: MODEL1310110045#
is version of: http://identifiers.org/ec-code/1.3.99.3
fast: false
type: Reaction

metaM aacoa c
initial concentration: 1.0
initial amount: NaN
has only substance units: false
is: SBO:0000247
is: HMDB01484
constant: false
boundary condition: false
name: Acetoacetyl-CoA
is: CHEBI:57286
type: Species
is: C00332
notes: FORMULA: C25H36N7O18P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00282 EHMN_ABBREVIATION: C00332

metaM HC01397 x
constant: false
is: CHEBI:27402
is: SBO:0000247
has only substance units: false
initial amount: NaN
notes: FORMULA: C37H62N7O18P3S CHARGE: -4 INCHI: InChI=1S/C37H66N7O18P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-25(45)20-28(47)66-19-18-39-27(46)16-17-40-35(50)32(49)37(2,3)22-59-65(56,57)62-64(54,55)58-21-26-31(61-63(51,52)53)30(48)36(60-26)44-24-43-29-33(38)41-23-42-34(29)44/h23-26,30-32,36,45,48-49H,4-22H2,1-3H3,(H,39,46)(H,40,50)(H,54,55)(H,56,57)(H2,38,41,42)(H2,51,52,53)/t25-,26+,30+,31+,32-,36+/m0/s1 EHMN_ABBREVIATION: C05258
type: Species
initial concentration: 1.0
name: (S)-3-Hydroxyhexadecanoyl-CoA
boundary condition: false

metaM dhcholestancoa x
name: 3alpha,7alpha-Dihydroxy-5beta-cholestanoyl-CoA
is: SBO:0000247
has only substance units: false
initial amount: NaN
is: HMDB02159
boundary condition: false
initial concentration: 1.0
notes: FORMULA: C48H76N7O19P3S CHARGE: -4 INCHI: InChI=1S/C48H80N7O19P3S/c1-26(30-10-11-31-36-32(13-16-48(30,31)6)47(5)15-12-29(56)20-28(47)21-33(36)57)8-7-9-27(2)45(62)78-19-18-50-35(58)14-17-51-43(61)40(60)46(3,4)23-71-77(68,69)74-76(66,67)70-22-34-39(73-75(63,64)65)38(59)44(72-34)55-25-54-37-41(49)52-24-53-42(37)55/h24-34,36,38-40,44,56-57,59-60H,7-23H2,1-6H3,(H,50,58)(H,51,61)(H,66,67)(H,68,69)(H2,49,52,53)(H2,63,64,65)/t26-,27?,28+,29-,30-,31+,32+,33-,34-,36+,38-,39-,40+,44-,47+,48-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01332 EHMN_ABBREVIATION: C04644
type: Species
is: CHEBI:15494
constant: false

http://identifiers.org/biomodels.db/MODEL1310110045#_e64ca2a3_511b_48b4_bf67_e499d8621c2d
initial concentration: NaN
constant: false
has only substance units: false
name: PLCB3
is encoded by: hsa:5331
boundary condition: true
is: SBO:0000252
initial amount: NaN
is: G5E960
type: Species

metaR NDPK3
reversible: true
is: SBO:0000176
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (4832.1) or (29922.2) or (4831.1 and 4830.1) or (29922.1) or (10201.1) or (4831.1 and 4830.2) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: NOTES:
is version of: http://identifiers.org/ec-code/2.7.4.6
fast: false
kinetic law: MODEL1310110045#
product: MODEL1310110045#
type: Reaction
reactant: MODEL1310110045#
modifier: MODEL1310110045#
name: nucleoside-diphosphate kinase (ATP:CDP)

metaR EX dtdp LPAREN e RPAREN
kinetic law: MODEL1310110045#
reactant: MODEL1310110045#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: ({[(2R,3S,5R)-3-hydroxy-5-(5-methyl-2,4-dioxo-1,2,3,4-tetrahydropyrimidin-1-yl)oxolan-2-yl]methyl phosphonato}oxy)phosphonate exchange
type: Reaction

metaM 2oxoadp m
has only substance units: false
type: Species
notes: FORMULA: C6H6O5 CHARGE: -2 INCHI: InChI=1S/C6H8O5/c7-4(6(10)11)2-1-3-5(8)9/h1-3H2,(H,8,9)(H,10,11)/p-2 HEPATONET_1.0_ABBREVIATION: HC00273 EHMN_ABBREVIATION: C00322
name: 2-oxoadipate(2-)
initial concentration: 1.0
is: SBO:0000247
is: CHEBI:57499
initial amount: NaN
constant: false
is: HMDB00225
boundary condition: false

metaR r0549
name: 4-aminobutanal:NAD+ 1-oxidoreductase; 4-aminobutyraldehyde:NAD+ oxidoreductase Urea cycle and metabolism of amino groups / beta-Alanine metabolism EC:1.2.1.3 EC:1.2.1.19
reactant: MODEL1310110045#
reversible: true
is version of: http://identifiers.org/ec-code/1.6.99.3
modifier: MODEL1310110045#
is: SBO:0000176
type: Reaction
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (AA629629.1) or (AA854479.1) or (AI345944.1) or (AI378339.1) or (AI601100.1) or (AI631997.1) or (AI935189.1) or (124454.1) or (F23536.1) or (FLJ44968.1) or (H45672.1) or (H53099.1) or (3550.1) or (LOC727762.1) or (4694.1) or (4705.1) or (126328.1) or (55967.1) or (51079.1) or (4695.1) or (4696.1) or (4697.1) or (56901.1) or (4698.1) or (4700.1) or (4701.1) or (4702.1) or (4704.1) or (4706.1) or (4707.1) or (4716.1) or (54539.1) or (4708.1) or (4709.1) or (4710.1) or (4711.1) or (4712.1) or (4713.1) or (4714.1) or (4715.1) or (4717.1) or (4718.1) or (4719.1) or (4720.1) or (4722.1) or (4724.1) or (4725.1) or (4726.1) or (374291.1) or (4728.1) or (4723.1) or (4729.1) or (4731.1) SUBSYSTEM: Glutamate metabolism EC Number: 1.2.1.3 Confidence Level: 0 AUTHORS: PMID:2925663,PMID:8155713,PMID:8269919,PMID:8786138,PMID:9417993 NOTES:
is version of: http://identifiers.org/ec-code/1.6.5.3
is version of: http://identifiers.org/ec-code/6.1.1.17
fast: false
kinetic law: MODEL1310110045#
product: MODEL1310110045#

http://identifiers.org/biomodels.db/MODEL1310110045#_2fb8e246_41fb_436c_8299_f56b2f49d4b3
initial concentration: NaN
name: ARSA
initial amount: NaN
is: SBO:0000252
has only substance units: false
constant: false
boundary condition: true
is encoded by: hsa:410
type: Species
is: P15289

metaM cs c deg2 l
is: HMDB00127
constant: false
initial amount: NaN
boundary condition: false
has only substance units: false
notes: FORMULA: C37H55NO38S2 CHARGE: -4
is: CHEBI:15748
is: SBO:0000247
initial concentration: 1.0
type: Species
name: chondroitin sulfate C (GalNAc6S-GlcA), degradation product 2

http://identifiers.org/biomodels.db/MODEL1310110045#_bbaecdc7_ec74_4300_80c8_961ebf565ebf
initial amount: NaN
is: SBO:0000252
type: Species
name: TBXAS1
constant: false
is: Q53F23
initial concentration: NaN
is encoded by: hsa:6916
has only substance units: false
boundary condition: true

metaM retinol 9 cis e
boundary condition: false
has only substance units: false
is: HMDB06217
is: SBO:0000247
initial concentration: 1.0
constant: false
is: CHEBI:17336
notes: FORMULA: C20H30O CHARGE: 0 INCHI: InChI=1S/C20H30O/c1-16(8-6-9-17(2)13-15-21)11-12-19-18(3)10-7-14-20(19,4)5/h6,8-9,11-13,21H,7,10,14-15H2,1-5H3/b9-6+,12-11+,16-8+,17-13+
initial amount: NaN
type: Species
name: 9-cis-retinol

metaR DSAT
notes: GENE_ASSOCIATION: SUBSYSTEM: Sphingolipid metabolism EC Number: Confidence Level: 2 AUTHORS: NOTES:CoA transfer not explicitly in rxn (accounted for in Rtotal rxn -> ARTF) NJ
is: SBO:0000176
name: dihydrosphingosine N-acyltransferase
reactant: MODEL1310110045#
product: MODEL1310110045#
type: Reaction
fast: false
kinetic law: MODEL1310110045#
is described by: ECO:0000000
reversible: false

metaR NDPK4
reactant: MODEL1310110045#
is described by: ECO:0000269
type: Reaction
notes: GENE_ASSOCIATION: (4832.1) or (4831.1 and 4830.1) or (10201.1) or (29922.2) or (29922.1) or (4831.1 and 4830.2) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: NOTES:
name: nucleoside-diphosphate kinase (ATP:dTDP)
modifier: MODEL1310110045#
reversible: true
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.7.4.6
fast: false
kinetic law: MODEL1310110045#
product: MODEL1310110045#

metaR r0311
is version of: http://identifiers.org/ec-code/2.3.1.16
reactant: MODEL1310110045#
is: SBO:0000176
name: Palmitate:CoA ligase (AMP-forming) Fatty acid metabolism EC:6.2.1.3
reversible: false
modifier: MODEL1310110045#
type: Reaction
product: MODEL1310110045#
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/2.3.1.9
fast: false
notes: GENE_ASSOCIATION: (30.1) or (10449.1) or (38.1) or (39.1) or (3032.1) or (4645.1) SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 0 AUTHORS: PMID:8584017 NOTES:
kinetic law: MODEL1310110045#

metaM dcsptn1coa x
notes: FORMULA: C43H64N7O17P3S CHARGE: -4 INCHI: InChI=1/C43H68N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-34(52)71-27-26-45-33(51)24-25-46-41(55)38(54)43(2,3)29-64-70(61,62)67-69(59,60)63-28-32-37(66-68(56,57)58)36(53)42(65-32)50-31-49-35-39(44)47-30-48-40(35)50/h8-9,11-12,14-15,17-18,20-21,30-32,36-38,42,53-54H,4-7,10,13,16,19,22-29H2,1-3H3,(H,45,51)(H,46,55)(H,59,60)(H,61,62)(H2,44,47,48)(H2,56,57,58)/b9-8-,12-11-,15-14-,18-17-,21-20-/t32-,36-,37?,38+,42-/m1/s1
constant: false
initial amount: NaN
is: http://identifiers.org/pubchem.compound/47205483
name: docosa-4,7,10,13,16-pentaenoyl coenzyme A
is: SBO:0000247
type: Species
boundary condition: false
has only substance units: false
initial concentration: 1.0
is: HMDB06513
is: C16173

http://identifiers.org/biomodels.db/MODEL1310110045#_45bf5b4a_def9_48f5_8184_ddc6aff326b5
is: P42126
has only substance units: false
type: Species
is encoded by: hsa:1632
constant: false
initial amount: NaN
is: SBO:0000252
name: ECI1
boundary condition: true
initial concentration: NaN

metaR DOLGLCP Lter
kinetic law: MODEL1310110045#
type: Reaction
reactant: MODEL1310110045#
product: MODEL1310110045#
fast: false
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: N-glycan synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:12137737 NOTES:
reversible: false
is described by: ECO:0000000
name: Dolichyl beta-D-glucosyl phosphate flippase (liver)

metaR ARSA
modifier: MODEL1310110045#
is: SBO:0000176
fast: false
product: MODEL1310110045#
notes: GENE_ASSOCIATION: (410.1) SUBSYSTEM: Sphingolipid metabolism EC Number: 3.1.6.8 Confidence Level: 4 AUTHORS: PMID:2562955 NOTES:NJ
reversible: false
is described by: ECO:0000000
kinetic law: MODEL1310110045#
type: Reaction
name: Arylsulfatase A
reactant: MODEL1310110045#
is version of: http://identifiers.org/ec-code/3.1.6.8

metaR FAOXC12DCC10DCx
kinetic law: MODEL1310110045#
product: MODEL1310110045#
reactant: MODEL1310110045#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C12DC-->C10DC)x
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110045#_2d4f04d8_c1c4_4c3f_946a_89b67ed71210
name: FASN
is: P49327
constant: false
is: SBO:0000252
is encoded by: hsa:2194
boundary condition: true
type: Species
initial amount: NaN
initial concentration: NaN
has only substance units: false

metaR DOLPMT3 Ler
product: MODEL1310110045#
modifier: MODEL1310110045#
name: dolichyl-phosphate-mannose-glycolipid alpha-mannosyltransferase (liver)
reactant: MODEL1310110045#
fast: false
type: Reaction
kinetic law: MODEL1310110045#
notes: GENE_ASSOCIATION: (79087.1) SUBSYSTEM: N-glycan synthesis EC Number: 2.4.1.130 Confidence Level: 0 AUTHORS: NOTES:NCD
is described by: ECO:0000000
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.4.1.260
reversible: false

metaR DTMPK
kinetic law: MODEL1310110045#
modifier: MODEL1310110045#
type: Reaction
notes: GENE_ASSOCIATION: (1841.1) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: NOTES:
reversible: true
is: SBO:0000176
name: dTMP kinase
reactant: MODEL1310110045#
fast: false
is version of: http://identifiers.org/ec-code/2.7.4.9
product: MODEL1310110045#
is described by: ECO:0000269

metaR ADSL2
reversible: false
reactant: MODEL1310110045#
modifier: MODEL1310110045#
is described by: ECO:0000269
fast: false
name: adenylosuccinate lyase
kinetic law: MODEL1310110045#
is: SBO:0000176
notes: GENE_ASSOCIATION: (158.1) or (158.2) SUBSYSTEM: Purine synthesis EC Number: 4.3.2.2 Confidence Level: 4 AUTHORS: PMID:1302001,PMID:2004782 NOTES:
product: MODEL1310110045#
is version of: http://identifiers.org/ec-code/4.3.2.2
type: Reaction

metaM fol c
type: Species
is: SBO:0000247
notes: FORMULA: C19H18N7O6 CHARGE: -1
name: Folate
constant: false
boundary condition: false
is: HMDB00121
has only substance units: false
initial concentration: 1.0
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110045#_997097bf_cf0c_48c0_add6_5b83bdeaa620
initial amount: NaN
name: _D87002_1_m
type: Species
constant: false
has only substance units: false
initial concentration: NaN
is: SBO:0000252
boundary condition: true
is encoded by: hsa:D87002

metaM pi n
name: hydrogenphosphate
notes: FORMULA: HO4P CHARGE: -2 INCHI: InChI=1S/H3O4P/c1-5(2,3)4/h(H3,1,2,3,4)/p-2 HEPATONET_1.0_ABBREVIATION: HC00019 EHMN_ABBREVIATION: C00009
constant: false
type: Species
initial concentration: 1.0
is: SBO:0000247
is: CHEBI:43474
initial amount: NaN
boundary condition: false
has only substance units: false
is: HMDB00973

metaM Rtotal2coa c
is: HMDB00095
is: SBO:0000247
is: C00055
initial concentration: 1.0
notes: FORMULA: CO2FULLR2C21H31N7O15P3S CHARGE: -4
type: Species
is: CHEBI:60377
has only substance units: false
constant: false
initial amount: NaN
name: R total 2 coenzyme A
boundary condition: false

metaM dhap c
is: SBO:0000247
is: CHEBI:57642
constant: false
has only substance units: false
is: HMDB01473
name: Dihydroxyacetone phosphate
is: C00111
initial amount: NaN
initial concentration: 1.0
type: Species
is: http://identifiers.org/pubchem.compound/3411
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110045#_6df3db4b_7a2b_49c5_93bc_7152643a1126
constant: false
initial concentration: NaN
name: SLC4A3
is encoded by: hsa:6508
has only substance units: false
initial amount: NaN
is: SBO:0000252
type: Species
is: P48751
boundary condition: true

metaM sph1p c
is: CHEBI:57939
name: (2S,3R)-2-azaniumyl-3-hydroxyoctadecyl phosphate
has only substance units: false
boundary condition: false
notes: FORMULA: C18H39NO5P CHARGE: -1 INCHI: InChI=1S/C18H40NO5P/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-18(20)17(19)16-24-25(21,22)23/h17-18,20H,2-16,19H2,1H3,(H2,21,22,23)/p-1/t17-,18+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00675 EHMN_ABBREVIATION: C01120
initial concentration: 1.0
initial amount: NaN
type: Species
constant: false
is: SBO:0000247
is: HMDB01383

metaR FAOXC204
type: Reaction
kinetic law: MODEL1310110045#
is version of: http://identifiers.org/ec-code/1.3.99.3
product: MODEL1310110045#
is version of: http://identifiers.org/ec-code/1.3.8.1
name: Beta oxidation of long chain fatty acid
reversible: false
fast: false
is: SBO:0000176
modifier: MODEL1310110045#
is described by: ECO:0000269
reactant: MODEL1310110045#
notes: GENE_ASSOCIATION: (35.1) or (35.1) or (34.1) or (34.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.99.3 Confidence Level: 4 AUTHORS: PMID:2565344,PMID:3035565 NOTES:TV Other enzymes: 1.3.3.6, 4.2.1.74, 4.2.1.17, 1.1.1.35, 1.1.1.211

metaR AHCYStd
type: Reaction
is described by: ECO:0000134
name: diffusion of S-Adenosyl-L-homocysteine
is: SBO:0000185
product: MODEL1310110045#
reversible: true
reactant: MODEL1310110045#
kinetic law: MODEL1310110045#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID: 8283303. NOTES:

metaM dcsptn1crn c
notes: FORMULA: C29H47NO4 CHARGE: 0 INCHI: InChI=1/C29H47NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-24-29(33)34-27(25-28(31)32)26-30(2,3)4/h9-10,12-13,15-16,18-19,21-22,27H,5-8,11,14,17,20,23-26H2,1-4H3/b10-9+,13-12+,16-15+,19-18+,22-21+
name: docosa-4,7,10,13,16-pentaenoyl carnitine
type: Species
is: HMDB06321
initial amount: NaN
is: SBO:0000247
constant: false
boundary condition: false
initial concentration: 1.0
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110045#_b28ed6ac_f02a_4aa6_80a5_d1946659eee7
initial concentration: NaN
is encoded by: hsa:27306
is: O60760
constant: false
has only substance units: false
type: Species
initial amount: NaN
is: SBO:0000252
boundary condition: true
name: HPGDS

metaM dolmanp L c
has only substance units: false
is: CHEBI:15809
initial amount: NaN
name: Dolichyl phosphate D-mannose, human liver homolog
is: SBO:0000247
initial concentration: 1.0
notes: FORMULA: C1140H1868O90P10 CHARGE: -10 INCHI: InChI=1S/C31H55O9P/c1-22(2)11-7-12-23(3)13-8-14-24(4)15-9-16-25(5)17-10-18-26(6)19-20-38-41(36,37)40-31-30(35)29(34)28(33)27(21-32)39-31/h11,13,15,17,26-35H,7-10,12,14,16,18-21H2,1-6H3,(H,36,37)/b23-13+,24-15+,25-17-/t26?,27-,28-,29+,30+,31?/m1/s1
type: Species
boundary condition: false
constant: false

http://identifiers.org/biomodels.db/MODEL1310110045#_b47ac02a_263b_49bb_a42c_ab157c241752
initial concentration: NaN
constant: false
boundary condition: true
initial amount: NaN
name: VNN1
is: O95497
is: SBO:0000252
is encoded by: hsa:8876
type: Species
has only substance units: false

metaR r0426
name: isocitrate hydro-lyase Citrate cycle (TCA cycle) / Glyoxylate and dicarboxylate metabolism EC:4.2.1.3
reactant: MODEL1310110045#
is version of: http://identifiers.org/ec-code/1.5.1.34
is: SBO:0000176
type: Reaction
fast: false
reversible: true
kinetic law: MODEL1310110045#
is described by: ECO:0000000
product: MODEL1310110045#
modifier: MODEL1310110045#
notes: GENE_ASSOCIATION: (5860.1) SUBSYSTEM: Unassigned EC Number: 4.2.1.3 Confidence Level: 0 AUTHORS: PMID:15263083,PMID:16511074 NOTES:

metaR DIGALSIDEtg
name: digalside hs intracellular transport
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 1 AUTHORS: NOTES:unknown mechanism for transport - however must get to other intracellular compartments (e.g. lysosome for degradation) NJ
type: Reaction
is: SBO:0000185
reactant: MODEL1310110045#
fast: false
is described by: ECO:0000000
reversible: true
kinetic law: MODEL1310110045#
product: MODEL1310110045#

metaR r2341
name: Organic anion transporter 5 Utilized transport
is described by: ECO:0000000
fast: false
kinetic law: MODEL1310110045#
is: SBO:0000185
product: MODEL1310110045#
reactant: MODEL1310110045#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
reversible: true

metaR EX cdp LPAREN e RPAREN
kinetic law: MODEL1310110045#
reactant: MODEL1310110045#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: CDP(3-) exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110045#_75f5fe93_dcff_430f_bee5_31646b28ef16
initial amount: NaN
is: SBO:0000252
is encoded by: hsa:7378
is: Q16831
name: UPP1
boundary condition: true
has only substance units: false
constant: false
initial concentration: NaN
type: Species

http://identifiers.org/biomodels.db/MODEL1310110045#_ff8be832_fed6_4768_9bec_f913a6eb6059
type: Species
constant: false
boundary condition: true
is: F5H123
initial amount: NaN
is encoded by: hsa:9856
name: DYLX2
has only substance units: false
initial concentration: NaN
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110045#_330baee1_a465_4dec_b694_42f5e3fe0675
has only substance units: false
name: _AA081045_1_e
is encoded by: hsa:AA081045
constant: false
type: Species
initial amount: NaN
initial concentration: NaN
is: SBO:0000252
boundary condition: true

metaM acgal c
type: Species
is: SBO:0000247
has only substance units: false
boundary condition: false
is: HMDB00212
name: N-acetyl-D-galactosamine
constant: false
notes: FORMULA: C8H15NO6 CHARGE: 0 INCHI: InChI=1S/C8H15NO6/c1-3(11)9-5-7(13)6(12)4(2-10)15-8(5)14/h4-8,10,12-14H,2H2,1H3,(H,9,11)/t4-,5-,6+,7-,8?/m1/s1 EHMN_ABBREVIATION: C01132
initial amount: NaN
initial concentration: 1.0
is: CHEBI:28037

metaM bhb e
notes: FORMULA: C4H7O3 CHARGE: -1 INCHI: InChI=1S/C4H8O3/c1-3(5)2-4(6)7/h3,5H,2H2,1H3,(H,6,7)/p-1/t3-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00661 EHMN_ABBREVIATION: C01089
is: HMDB00011
initial concentration: 1.0
is: SBO:0000247
constant: false
name: (R)-3-hydroxybutyrate
has only substance units: false
is: CHEBI:10983
type: Species
boundary condition: false
initial amount: NaN

metaR AG13T7g
notes: GENE_ASSOCIATION: (79369.1) or (374907.1) or (11041.1) or (146712.1) or (374907.2) or (93010.1) or (10331.1) or (10678.1) or (10678.2) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.149 Confidence Level: 4 AUTHORS: PMID:10747980,PMID:11042166,PMID:12061784,PMID:12512857,PMID:15560372,PMID:15620693,PMID:9405606 NOTES:NCD
type: Reaction
kinetic law: MODEL1310110045#
modifier: MODEL1310110045#
fast: false
reactant: MODEL1310110045#
is version of: http://identifiers.org/ec-code/2.4.1.149
product: MODEL1310110045#
reversible: false
is: SBO:0000176
name: N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase, Golgi apparatus
is described by: ECO:0000000

metaM 3ohdcoa m
notes: FORMULA: C37H60N7O18P3S CHARGE: -4 INCHI: InChI=1S/C37H64N7O18P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-25(45)20-28(47)66-19-18-39-27(46)16-17-40-35(50)32(49)37(2,3)22-59-65(56,57)62-64(54,55)58-21-26-31(61-63(51,52)53)30(48)36(60-26)44-24-43-29-33(38)41-23-42-34(29)44/h23-24,26,30-32,36,48-49H,4-22H2,1-3H3,(H,39,46)(H,40,50)(H,54,55)(H,56,57)(H2,38,41,42)(H2,51,52,53)/p-4/t26-,30-,31-,32+,36-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01398 EHMN_ABBREVIATION: C05259
constant: false
is: HMDB06402
initial concentration: 1.0
name: 3-oxopalmitoyl-CoA(4-)
is: CHEBI:57349
has only substance units: false
initial amount: NaN
is: SBO:0000247
boundary condition: false
type: Species

metaR ADSL1
type: Reaction
fast: false
notes: GENE_ASSOCIATION: (158.1) or (158.2) SUBSYSTEM: Nucleotide interconversion EC Number: 4.3.2.2 Confidence Level: 4 AUTHORS: PMID:1302001,PMID:2004782 NOTES:
name: adenylosuccinate lyase
is version of: http://identifiers.org/ec-code/4.3.2.2
modifier: MODEL1310110045#
product: MODEL1310110045#
reactant: MODEL1310110045#
is: SBO:0000176
kinetic law: MODEL1310110045#
reversible: false
is described by: ECO:0000269

metaR CYSTGLUex
is: SBO:0000185
notes: GENE_ASSOCIATION: (23657.1 and 6520.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14770310 NOTES:SAB see PMID 14770310
kinetic law: MODEL1310110045#
product: MODEL1310110045#
modifier: MODEL1310110045#
is described by: ECO:0000269
name: L-cystine/L-glutamate exchanger
type: Reaction
fast: false
reversible: false
reactant: MODEL1310110045#

metaR AHCYSte
fast: false
reversible: true
is described by: ECO:0000134
is: SBO:0000185
product: MODEL1310110045#
type: Reaction
reactant: MODEL1310110045#
kinetic law: MODEL1310110045#
name: Transport of S-adenosyl-L-homocysteine
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:

metaR ADNK1m
type: Reaction
reversible: false
reactant: MODEL1310110045#
notes: GENE_ASSOCIATION: SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.1.20 Confidence Level: 1 AUTHORS: NOTES:IT
is: SBO:0000176
fast: false
is described by: ECO:0000000
kinetic law: MODEL1310110045#
product: MODEL1310110045#
name: adenosine kinase, mitochondrial

metaR BUTt2r
kinetic law: MODEL1310110045#
reversible: true
name: Butyrate transport via proton symport, reversible
product: MODEL1310110045#
is described by: ECO:0000269
type: Reaction
reactant: MODEL1310110045#
is: SBO:0000185
modifier: MODEL1310110045#
notes: GENE_ASSOCIATION: (6566.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10510291,PMID:11827462,PMID:12739169,PMID:7835905,PMID:8476015,PMID:9508842,PMID:9649795,PMID:9824713 NOTES:JLR
fast: false

http://identifiers.org/biomodels.db/MODEL1310110045#_dfec6581_685b_4008_88e5_c1a0f788ac0e
name: SLC12A4
is: SBO:0000252
initial amount: NaN
constant: false
has only substance units: false
boundary condition: true
type: Species
is: F5H066
initial concentration: NaN
is encoded by: hsa:6560

metaM dcamp c
constant: false
name: N6-(1,2-Dicarboxyethyl)-AMP
notes: FORMULA: C14H14N5O11P CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC01183 EHMN_ABBREVIATION: C03794
is: C03794
initial amount: NaN
has only substance units: false
is: SBO:0000247
initial concentration: 1.0
boundary condition: false
type: Species
is: HMDB00536
is: CHEBI:57567

http://identifiers.org/biomodels.db/MODEL1310110045#_51b417f3_3a19_450b_93f5_2e14f4ae0a7a
is: P31350
is: SBO:0000252
has only substance units: false
type: Species
name: RRM2
boundary condition: true
initial concentration: NaN
constant: false
is encoded by: hsa:6241
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110045#_ac15342f_ed68_4407_b4fb_414b92347919
boundary condition: true
is encoded by: hsa:1337
initial amount: NaN
constant: false
has only substance units: false
is: P12074
initial concentration: NaN
is: SBO:0000252
name: COX6A1
type: Species

http://identifiers.org/biomodels.db/MODEL1310110045#_fe5fe5f2_1346_4cc5_a0d2_3273da28e6ae
initial amount: NaN
type: Species
boundary condition: true
is: SBO:0000252
is encoded by: hsa:226
name: ALDOA
has only substance units: false
constant: false
initial concentration: NaN

metaM crm hs g
initial amount: NaN
type: Species
name: N-acylsphingosine
initial concentration: 1.0
is: SBO:0000247
notes: FORMULA: C18H36NO2FULLRCO CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC01990 EHMN_ABBREVIATION: C00195
is: CHEBI:52639
constant: false
has only substance units: false
boundary condition: false

metaR EX ac LPAREN e RPAREN
kinetic law: MODEL1310110045#
reactant: MODEL1310110045#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Acetate exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110045#_6d2ea839_d7f7_433e_8fd5_fd9f00a5a968
boundary condition: true
is: SBO:0000252
initial amount: NaN
is: Q16222
has only substance units: false
constant: false
initial concentration: NaN
type: Species
is encoded by: hsa:6675
name: UAP1

http://identifiers.org/biomodels.db/MODEL1310110045#_a50cb50d_6f0d_4874_bfbc_b963e3827cd9
initial amount: NaN
has only substance units: false
type: Species
constant: false
name: NOS3
is: A0S0A7
is encoded by: hsa:4846
initial concentration: NaN
boundary condition: true
is: SBO:0000252

metaR EX 2hb LPAREN e RPAREN
kinetic law: MODEL1310110045#
reactant: MODEL1310110045#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 2-Hydroxybutyrate exchange
type: Reaction

metaR GASNASE2ly
kinetic law: MODEL1310110045#
reactant: MODEL1310110045#
notes: GENE_ASSOCIATION: (175.1) SUBSYSTEM: N-glycan degradation EC Number: 3.5.1.26 Confidence Level: 0 AUTHORS: NOTES:NCD
reversible: false
name: glycosylasparaginase, lysosomal
is version of: http://identifiers.org/ec-code/3.5.1.26
is: SBO:0000176
fast: false
product: MODEL1310110045#
is described by: ECO:0000000
type: Reaction
modifier: MODEL1310110045#

http://identifiers.org/biomodels.db/MODEL1310110045#_81440695_0fea_40f3_9cd2_ddbb18874b36
boundary condition: true
has only substance units: false
constant: false
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:3074
name: HEXB
is: P07686
type: Species
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110045#_287408a4_9570_4a7e_8667_fb727ed0c795
initial amount: NaN
initial concentration: NaN
type: Species
has only substance units: false
is encoded by: hsa:1351
constant: false
is: Q53XN1
name: COX8A
is: SBO:0000252
boundary condition: true

metaM bhb c
initial amount: NaN
initial concentration: 1.0
name: (R)-3-hydroxybutyrate
is: HMDB00011
has only substance units: false
is: SBO:0000247
constant: false
boundary condition: false
is: CHEBI:10983
notes: FORMULA: C4H7O3 CHARGE: -1 INCHI: InChI=1S/C4H8O3/c1-3(5)2-4(6)7/h3,5H,2H2,1H3,(H,6,7)/p-1/t3-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00661 EHMN_ABBREVIATION: C01089
type: Species

metaR r0650
reversible: true
name: Chenodeoxycholate:CoA ligase (AMP-forming) Bile acid biosynthesis EC:6.2.1.7
reactant: MODEL1310110045#
is: SBO:0000176
fast: false
product: MODEL1310110045#
is described by: ECO:0000000
modifier: MODEL1310110045#
notes: GENE_ASSOCIATION: (60490.1) SUBSYSTEM: Bile acid synthesis EC Number: 6.2.1.7 Confidence Level: 0 AUTHORS: PMID:10749848,PMID:10884298,PMID:15026425,PMID:438652,PMID:6173037 NOTES:
type: Reaction
kinetic law: MODEL1310110045#
is version of: http://identifiers.org/ec-code/4.1.1.36

http://identifiers.org/biomodels.db/MODEL1310110045#_9b245bd1_b5bd_40c0_a6eb_87b000e98690
is: SBO:0000252
type: Species
constant: false
has only substance units: false
name: PANK1
initial amount: NaN
boundary condition: true
is encoded by: hsa:53354
initial concentration: NaN

metaM pi m
has only substance units: false
initial amount: NaN
notes: FORMULA: HO4P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00019 EHMN_ABBREVIATION: C00009
initial concentration: 1.0
is: CHEBI:43474
type: Species
constant: false
is: SBO:0000247
boundary condition: false
is: HMDB00973
is: C00009
name: hydrogenphosphate

http://identifiers.org/biomodels.db/MODEL1310110045#_2a2df958_f482_4e51_ade5_bfde8dc3ceac
constant: false
initial concentration: NaN
has only substance units: false
boundary condition: true
is encoded by: hsa:5315
is: B4DNK4
name: PKM2
type: Species
is: SBO:0000252
initial amount: NaN

metaM acnam l
is: SBO:0000247
name: N-acetylneuraminate
is: CHEBI:35418
notes: FORMULA: C11H18NO9 CHARGE: -1 INCHI: InChI=1S/C11H19NO9/c1-4(14)12-7-5(15)2-11(20,10(18)19)21-9(7)8(17)6(16)3-13/h5-9,13,15-17,20H,2-3H2,1H3,(H,12,14)(H,18,19)/p-1/t5-,6+,7+,8+,9+,11?/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00244 EHMN_ABBREVIATION: C00270
boundary condition: false
initial concentration: 1.0
type: Species
constant: false
has only substance units: false
initial amount: NaN
is: HMDB00230

metaM ksi pre19 g
initial concentration: 1.0
initial amount: NaN
is: SBO:0000247
is: HMDB00175
boundary condition: false
constant: false
is: C00130
is: CHEBI:58053
name: keratan sulfate I biosynthesis, precursor 19
type: Species
has only substance units: false
notes: FORMULA: C171H275N12O137S5X CHARGE: -6

metaR CYTK11
reversible: true
name: cytidylate kinase (dCMP,dGTP)
is: SBO:0000176
type: Reaction
reactant: MODEL1310110045#
is described by: ECO:0000269
product: MODEL1310110045#
is version of: http://identifiers.org/ec-code/2.7.4.14
modifier: MODEL1310110045#
kinetic law: MODEL1310110045#
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
fast: false

metaR r0870
reactant: MODEL1310110045#
is version of: http://identifiers.org/ec-code/3.6.1.1
product: MODEL1310110045#
kinetic law: MODEL1310110045#
is version of: http://identifiers.org/ec-code/3.6.4.13
modifier: MODEL1310110045#
is version of: http://identifiers.org/ec-code/2.7.7.72
fast: false
type: Reaction
is version of: http://identifiers.org/ec-code/3.1.3.4
is: SBO:0000185
notes: GENE_ASSOCIATION: (AA419122.1) or (AA576959.1) or (64077.1) or (8776.1) or (8898.1) or (9107.1) or (29085.1) or (8611.1) or (8613.1) or (8612.1) or (81537.1) or (130367.1) or (23517.1) or (51095.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14977409,PMID:17466261 NOTES:
reversible: true
name: Facilitated diffusion
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110045#_4cae5b51_0711_40b3_b001_d7f3cd2f8c0f
is encoded by: hsa:7378
constant: false
type: Species
has only substance units: false
initial amount: NaN
name: UPP1
is: SBO:0000252
initial concentration: NaN
boundary condition: true

metaR VALLAT1tc
kinetic law: MODEL1310110045#
product: MODEL1310110045#
reactant: MODEL1310110045#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of L-Valine by LAT1 in association with 4F2hc, across the apical surface of the memebranes.
type: Reaction

metaM ksii core2 pre10 g
initial concentration: 1.0
notes: FORMULA: C81H130N6O64S2X CHARGE: -3
name: keratan sulfate II biosynthesis, precursor 10
is: SBO:0000247
is: CHEBI:28067
type: Species
boundary condition: false
constant: false
has only substance units: false
initial amount: NaN

metaR CAATPS
notes: GENE_ASSOCIATION: (492.1) or (491.1) or (490.1) or (493.1) SUBSYSTEM: Transport, extracellular EC Number: 3.6.3.6 Confidence Level: 4 AUTHORS: PMID:7876199,PMID:8396145 NOTES:plasma membrane version (SR and ER versions also exist) stoichiometry actually varies (number of Ca/ATP transported). See PMID: 7876199 NJ
kinetic law: MODEL1310110045#
type: Reaction
is: SBO:0000185
name: Ca ATPase
reactant: MODEL1310110045#
is described by: ECO:0000269
modifier: MODEL1310110045#
reversible: false
fast: false
product: MODEL1310110045#
is version of: http://identifiers.org/ec-code/3.6.3.8

http://identifiers.org/biomodels.db/MODEL1310110045#_347aa379_0bff_4c66_9a5d_645b7e7a2346
initial amount: NaN
initial concentration: NaN
boundary condition: true
type: Species
name: CTSA
is: P10619
has only substance units: false
constant: false
is encoded by: hsa:5476
is: SBO:0000252

metaR KCC2t
product: MODEL1310110045#
fast: false
reactant: MODEL1310110045#
modifier: MODEL1310110045#
is: SBO:0000185
kinetic law: MODEL1310110045#
name: K+-Cl- cotransporter (NH4+)
notes: GENE_ASSOCIATION: (6560.1) or (10723.1) or (9990.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10187864,PMID:10347194,PMID:10600773,PMID:121106695,PMID:12657561,PMID:8663127 NOTES:NCD
type: Reaction
reversible: true
is described by: ECO:0000269

http://identifiers.org/biomodels.db/MODEL1310110045#_49d67fd7_c013_410e_8123_ffb77867a7b4
has only substance units: false
name: NDUFS1
initial amount: NaN
is: P28331
initial concentration: NaN
type: Species
is: SBO:0000252
is encoded by: hsa:4719
boundary condition: true
constant: false

metaR SCPx
reactant: MODEL1310110045#
is version of: http://identifiers.org/ec-code/2.3.1.176
reversible: false
type: Reaction
is described by: ECO:0000269
name: peroxisomal thiolase 2
kinetic law: MODEL1310110045#
notes: GENE_ASSOCIATION: (6342.1) SUBSYSTEM: Bile acid synthesis EC Number: Confidence Level: 4 AUTHORS: NOTES:SCP has two transcripts, second isoform specific to peroxisomes, first is specific for cyt and mit need to double check stoichiometry - reaction cofactors (additional coa + release of prop coa) from BM (Roche) Biochemical Pathways NJ
product: MODEL1310110045#
modifier: MODEL1310110045#
is: SBO:0000176
fast: false

metaR CYTK12
reactant: MODEL1310110045#
modifier: MODEL1310110045#
is described by: ECO:0000269
is: SBO:0000176
type: Reaction
product: MODEL1310110045#
reversible: true
is version of: http://identifiers.org/ec-code/2.7.4.14
fast: false
kinetic law: MODEL1310110045#
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
name: cytidylate kinase (dCMP,dCTP)

metaR sink 5hpet LPAREN c RPAREN
kinetic law: MODEL1310110045#
reactant: MODEL1310110045#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: sink reaction for 5(S)-HPETE(1-)
type: Reaction

metaR r0009
name: Pyrophosphate phosphohydrolase EC:3.6.1.1
notes: GENE_ASSOCIATION: (AI990637.1) or (64077.1) or (5464.1) or (27068.1) SUBSYSTEM: Purine catabolism EC Number: 3.6.1.1 Confidence Level: 0 AUTHORS: PMID:10542310,PMID:16300924 NOTES:IT - fixed proton
reactant: MODEL1310110045#
is version of: http://identifiers.org/ec-code/3.6.1.1
modifier: MODEL1310110045#
reversible: false
kinetic law: MODEL1310110045#
product: MODEL1310110045#
type: Reaction
is: SBO:0000176
is described by: ECO:0000000
fast: false

metaM pi r
name: hydrogenphosphate
type: Species
initial amount: NaN
is: SBO:0000247
boundary condition: false
is: C00009
notes: FORMULA: HO4P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00019 EHMN_ABBREVIATION: C00009
is: HMDB00973
initial concentration: 1.0
is: CHEBI:43474
has only substance units: false
constant: false

metaR MDHx
is described by: ECO:0000134
name: malate dehydrogenase, peroxisomal
fast: false
product: MODEL1310110045#
type: Reaction
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Citric acid cycle EC Number: Confidence Level: 2 AUTHORS: PMID: 17173541 NOTES:added during gap filling. Assumption that such a reaction can exist. Mamalian peroxisome do not contain malate dehydrogenase.
kinetic law: MODEL1310110045#
reversible: true
reactant: MODEL1310110045#

http://identifiers.org/biomodels.db/MODEL1310110045#_95052bfd_105a_43d1_a2d6_18c1c82e5d2d
is: SBO:0000252
initial concentration: NaN
is encoded by: hsa:4830
constant: false
name: NME1
boundary condition: true
initial amount: NaN
type: Species
is: P15531
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110045#_6af38b28_9f97_4f83_8d48_dde5ca130173
constant: false
name: UCK1
initial concentration: NaN
has only substance units: false
is: Q5JT09
type: Species
is encoded by: hsa:83549
is: SBO:0000252
initial amount: NaN
boundary condition: true

metaR ALOX52
name: Arachidonate 5-lipoxygenase
type: Reaction
is described by: ECO:0000269
reversible: false
product: MODEL1310110045#
reactant: MODEL1310110045#
fast: false
is version of: http://identifiers.org/ec-code/1.13.11.34
is: SBO:0000176
modifier: MODEL1310110045#
kinetic law: MODEL1310110045#
notes: GENE_ASSOCIATION: (240.1) SUBSYSTEM: Eicosanoid metabolism EC Number: 1.13.11.34 Confidence Level: 4 AUTHORS: PMID:11160764 NOTES:cofactors + usage still not clear unknown mechanism - biochemistry supported by PMID: 2829172, 11160764

metaM 4hexdtetcoa m
is: HMDB02288
name: 4,7,10,13-hexadecatetraenoylcoa
notes: FORMULA: C37H54N7O17P3S CHARGE: -4
constant: false
initial concentration: 1.0
is: SBO:0000247
has only substance units: false
type: Species
boundary condition: false
initial amount: NaN

metaR r2121
reactant: MODEL1310110045#
product: MODEL1310110045#
reversible: true
is: SBO:0000185
kinetic law: MODEL1310110045#
fast: false
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
modifier: MODEL1310110045#
is described by: ECO:0000000
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
type: Reaction

metaR GLYtm
name: glycine passive transport to mitochondria
kinetic law: MODEL1310110045#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:7388024 NOTES:TDV Biochim Biophys Acta. 1980 Jun 6;598(3):588-94
reactant: MODEL1310110045#
is described by: ECO:0000000
product: MODEL1310110045#
type: Reaction
reversible: true
is: SBO:0000185
fast: false

metaM frdp c
type: Species
constant: false
is: C00448
is: SBO:0000247
notes: FORMULA: C15H25O7P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00362 EHMN_ABBREVIATION: C00448
has only substance units: false
is: HMDB00961
boundary condition: false
initial amount: NaN
name: Farnesyl diphosphate
initial concentration: 1.0
is: CHEBI:175763

metaM arachcoa c
is: SBO:0000247
initial amount: NaN
notes: FORMULA: C41H70N7O17P3S CHARGE: -4 INCHI: InChI=1S/C41H74N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-32(50)69-25-24-43-31(49)22-23-44-39(53)36(52)41(2,3)27-62-68(59,60)65-67(57,58)61-26-30-35(64-66(54,55)56)34(51)40(63-30)48-29-47-33-37(42)45-28-46-38(33)48/h28-30,34-36,40,51-52H,4-27H2,1-3H3,(H,43,49)(H,44,53)(H,57,58)(H,59,60)(H2,42,45,46)(H2,54,55,56)/t30-,34-,35-,36+,40-/m1/s1 EHMN_ABBREVIATION: C02041
constant: false
is: CHEBI:15527
has only substance units: false
name: arachidyl coenzyme A
boundary condition: false
type: Species
initial concentration: 1.0
is: HMDB04258

metaM glyc3p x
notes: FORMULA: C3H7O6P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00095 EHMN_ABBREVIATION: C00093
initial concentration: 1.0
is: CHEBI:57597
initial amount: NaN
is: HMDB00126
name: Glycerol 3-phosphate
constant: false
is: SBO:0000247
boundary condition: false
has only substance units: false
type: Species
is: C00093

metaR PGDI
notes: GENE_ASSOCIATION: (5730.1) or (27306.1) SUBSYSTEM: Eicosanoid metabolism EC Number: 5.3.99.2 Confidence Level: 4 AUTHORS: PMID:9065498,PMID:9353279 NOTES:noted on RER, but also cytoplasmic structures NJ
reactant: MODEL1310110045#
modifier: MODEL1310110045#
is version of: http://identifiers.org/ec-code/2.5.1.18
kinetic law: MODEL1310110045#
type: Reaction
is version of: http://identifiers.org/ec-code/5.3.99.2
name: Prostaglandin-H2 D-isomerase [Precursor]
is: SBO:0000176
reversible: true
product: MODEL1310110045#
fast: false
is described by: ECO:0000269

metaR CYTK10
reactant: MODEL1310110045#
is version of: http://identifiers.org/ec-code/2.7.4.14
name: cytidylate kinase (CMP,dGTP)
is described by: ECO:0000269
product: MODEL1310110045#
reversible: true
is: SBO:0000176
kinetic law: MODEL1310110045#
type: Reaction
fast: false
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
modifier: MODEL1310110045#

metaR EX cys L LPAREN e RPAREN
kinetic law: MODEL1310110045#
reactant: MODEL1310110045#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for L-cysteine
type: Reaction

metaR r2120
product: MODEL1310110045#
modifier: MODEL1310110045#
reactant: MODEL1310110045#
kinetic law: MODEL1310110045#
is: SBO:0000185
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
type: Reaction
fast: false
reversible: true
name: Major Facilitator(MFS) TCDB:2.A.1.13.1

metaM sbcoa x
constant: false
notes: FORMULA: C29H43N7O19P3S CHARGE: -5
is: http://identifiers.org/pubchem.compound/16019966
boundary condition: false
has only substance units: false
name: suberylcoa
is: SBO:0000247
initial concentration: 1.0
type: Species
initial amount: NaN

metaM dtmp m
is: C00364
constant: false
is: SBO:0000247
has only substance units: false
boundary condition: false
is: HMDB01227
initial concentration: 1.0
type: Species
name: dTMP
notes: FORMULA: C10H13N2O8P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00308 EHMN_ABBREVIATION: C00364
initial amount: NaN
is: CHEBI:26999

http://identifiers.org/biomodels.db/MODEL1310110045#_a9042860_aef8_4902_8145_0a174e607c74
is: SBO:0000297
initial amount: NaN
name: VNN3:VNN2:VNN1
has part: O95498
boundary condition: true
type: Species
initial concentration: NaN
is encoded by: hsa:8875
constant: false
has only substance units: false
is encoded by: hsa:55350

http://identifiers.org/biomodels.db/MODEL1310110045#_fb6fec28_11c9_4c4b_9d4f_9e3dd0833d19
initial concentration: NaN
is: P07195
initial amount: NaN
has only substance units: false
is encoded by: hsa:3945
is: SBO:0000252
name: LDHB
constant: false
type: Species
boundary condition: true

metaR SRTNtu
product: MODEL1310110045#
modifier: MODEL1310110045#
is: SBO:0000185
type: Reaction
notes: GENE_ASSOCIATION: (6580.1) or (6582.2) or (6582.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12883891 NOTES:SAB electrogenic, Na indepdendent & rev NJ
fast: false
reversible: true
reactant: MODEL1310110045#
kinetic law: MODEL1310110045#
is described by: ECO:0000269
name: Serotonin uniport

metaR r0208
fast: false
kinetic law: MODEL1310110045#
is: SBO:0000176
name: GTP:alpha-D-mannose-1-phosphate guanylyltransferase Fructose and mannose metabolism EC:2.7.7.13
is described by: ECO:0000000
type: Reaction
notes: GENE_ASSOCIATION: (1491.1) SUBSYSTEM: Fructose and mannose metabolism EC Number: 2.7.7.13 Confidence Level: 0 AUTHORS: PMID:10025667,PMID:8549746,PMID:9451026 NOTES:
product: MODEL1310110045#
reactant: MODEL1310110045#
reversible: true
modifier: MODEL1310110045#
is version of: http://identifiers.org/ec-code/4.4.1.1

metaR r2123
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
is: SBO:0000185
reactant: MODEL1310110045#
modifier: MODEL1310110045#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
kinetic law: MODEL1310110045#
is described by: ECO:0000000
reversible: true
fast: false
type: Reaction
product: MODEL1310110045#

metaM csn e
notes: FORMULA: C4H5N3O CHARGE: 0 INCHI: InChI=1S/C4H5N3O/c5-3-1-2-6-4(8)7-3/h1-2H,(H3,5,6,7,8)
type: Species
is: CHEBI:16040
is: SBO:0000247
has only substance units: false
initial amount: NaN
constant: false
boundary condition: false
is: HMDB00630
name: cytosine
initial concentration: 1.0

metaR ACONTm
is: SBO:0000176
name: Aconitate hydratase
product: MODEL1310110045#
reactant: MODEL1310110045#
is version of: http://identifiers.org/ec-code/4.2.1.3
kinetic law: MODEL1310110045#
modifier: MODEL1310110045#
reversible: true
fast: false
notes: GENE_ASSOCIATION: (50.1) SUBSYSTEM: Citric acid cycle EC Number: 4.2.1.3 Confidence Level: 0 AUTHORS: PMID:10419470,PMID:17244191,PMID:17244192 NOTES:IF. Biochemical
is described by: ECO:0000134
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110045#_59745a27_645b_42d7_9e7a_8b4c83a51183
name: DGUOK
is: E5KSL6
is encoded by: hsa:1716
type: Species
constant: false
has only substance units: false
is: SBO:0000252
boundary condition: true
initial concentration: NaN
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110045#_aa6ef02b_567c_4e7f_ba84_89bdeb9604ff
type: Species
is: Q8IW54
is encoded by: hsa:5138
initial amount: NaN
boundary condition: true
is: SBO:0000252
has only substance units: false
initial concentration: NaN
constant: false
name: PDE2A

metaR r0990
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 0 AUTHORS: PMID:10884298,PMID:6469982 NOTES:
fast: false
product: MODEL1310110045#
kinetic law: MODEL1310110045#
type: Reaction
is described by: ECO:0000000
reversible: true
is: SBO:0000185
reactant: MODEL1310110045#
name: Postulated transport reaction

metaR PIt8
reversible: true
reactant: MODEL1310110045#
product: MODEL1310110045#
type: Reaction
notes: GENE_ASSOCIATION: (6574.1) or (6575.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12759754 NOTES:MM
fast: false
name: phosphate transport in/out via Na+ symporter
kinetic law: MODEL1310110045#
modifier: MODEL1310110045#
is: SBO:0000185
is described by: ECO:0000006

metaR O2St
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:12939409 NOTES:
fast: false
product: MODEL1310110045#
name: superoxide anion transport via diffusion (extracellular)
is described by: ECO:0000000
kinetic law: MODEL1310110045#
type: Reaction
is: SBO:0000185
reversible: true
reactant: MODEL1310110045#

metaM 2oxoadp c
is: SBO:0000247
initial amount: NaN
type: Species
notes: FORMULA: C6H6O5 CHARGE: -2 INCHI: InChI=1S/C6H8O5/c7-4(6(10)11)2-1-3-5(8)9/h1-3H2,(H,8,9)(H,10,11)/p-2 HEPATONET_1.0_ABBREVIATION: HC00273 EHMN_ABBREVIATION: C00322
has only substance units: false
initial concentration: 1.0
name: 2-oxoadipate(2-)
is: CHEBI:57499
constant: false
boundary condition: false
is: HMDB00225

metaM ksi deg2 l
type: Species
name: keratan sulfate I, degradation product 2
initial concentration: 1.0
initial amount: NaN
has only substance units: false
is: SBO:0000247
is: HMDB01356
is: CHEBI:57312
notes: FORMULA: C241H384N17O210S12 CHARGE: -13
constant: false
boundary condition: false

metaR r2122
modifier: MODEL1310110045#
kinetic law: MODEL1310110045#
is: SBO:0000185
reactant: MODEL1310110045#
product: MODEL1310110045#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
is described by: ECO:0000000
type: Reaction
fast: false
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110045#_961647bb_de68_4979_a5d8_232004bf5fcc
initial concentration: NaN
type: Species
constant: false
is: SBO:0000252
name: ALAS1
boundary condition: true
is encoded by: hsa:211
has only substance units: false
initial amount: NaN
is: P13196

http://identifiers.org/biomodels.db/MODEL1310110045#_08bbd5a5_2984_4ac0_b028_60c0ab67b5be
boundary condition: true
is: SBO:0000252
initial concentration: NaN
type: Species
constant: false
initial amount: NaN
has only substance units: false
is encoded by: hsa:23430
is: Q9BZJ3
name: TPSD1

metaR PIt7
notes: GENE_ASSOCIATION: (10050.1) or (10786.1) or (10246.1) or (6568.1) or (6569.1) or (10568.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12750889,PMID:12811560,PMID:8815811 NOTES:Merged GPRs from PIt7 and PIt7r. May 2011 IT
fast: false
name: phosphate transport in/out via three Na+ symporter
kinetic law: MODEL1310110045#
reversible: true
is: SBO:0000185
type: Reaction
modifier: MODEL1310110045#
reactant: MODEL1310110045#
is described by: ECO:0000269
product: MODEL1310110045#

metaR r0993
reactant: MODEL1310110045#
is described by: ECO:0000000
fast: false
product: MODEL1310110045#
name: ATP-binding Cassette (ABC) TCDB:3.A.1.208.2
kinetic law: MODEL1310110045#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14716480,PMID:15209530,PMID:15297262 NOTES:
is: SBO:0000185
type: Reaction
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110045#_964404c2_501c_458a_87e9_7d0459cb5873
name: AMPD2
has only substance units: false
is encoded by: hsa:271
initial amount: NaN
constant: false
boundary condition: true
is: E9PNG0
is: SBO:0000252
initial concentration: NaN
type: Species

metaR CYTK13
reversible: true
is: SBO:0000176
type: Reaction
is described by: ECO:0000269
reactant: MODEL1310110045#
is version of: http://identifiers.org/ec-code/2.7.4.14
name: cytidylate kinase (dCMP,dATP)
modifier: MODEL1310110045#
kinetic law: MODEL1310110045#
product: MODEL1310110045#
fast: false
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:

metaR RPE
kinetic law: MODEL1310110045#
is version of: http://identifiers.org/ec-code/5.1.3.1
product: MODEL1310110045#
reversible: true
name: ribulose 5-phosphate 3-epimerase
type: Reaction
is: SBO:0000176
fast: false
is described by: ECO:0000000
reactant: MODEL1310110045#
notes: GENE_ASSOCIATION: (6120.1) or (6120.2) SUBSYSTEM: Pentose phosphate pathway EC Number: 5.1.3.1 Confidence Level: 0 AUTHORS: NOTES:SMP
modifier: MODEL1310110045#

http://identifiers.org/biomodels.db/MODEL1310110045#_33e97cc8_4371_405e_bf27_796de3f5a513
is encoded by: hsa:50484
is: SBO:0000252
initial amount: NaN
has only substance units: false
type: Species
initial concentration: NaN
is: Q7LG56
name: RRM2B
boundary condition: true
constant: false

http://identifiers.org/biomodels.db/MODEL1310110045#_0dbff0d8_28e6_4441_be87_2b689b6c36f7
is: O00476
constant: false
name: SLC17A3
initial concentration: NaN
type: Species
boundary condition: true
initial amount: NaN
has only substance units: false
is encoded by: hsa:10786
is: SBO:0000252

metaR EX arab L LPAREN e RPAREN
kinetic law: MODEL1310110045#
reactant: MODEL1310110045#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: L-Arabinose exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110045#_3de2ab7e_a2c7_4085_a0ca_9f86cb74c624
has only substance units: false
type: Species
is encoded by: hsa:6530
initial concentration: NaN
is: SBO:0000252
is: Q96KH8
name: SLC6A2
initial amount: NaN
boundary condition: true
constant: false

metaR r2125
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
modifier: MODEL1310110045#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
kinetic law: MODEL1310110045#
is described by: ECO:0000000
type: Reaction
fast: false
reversible: true
is: SBO:0000185
reactant: MODEL1310110045#
product: MODEL1310110045#

http://identifiers.org/biomodels.db/MODEL1310110045#_23422701_67e8_4ca8_9039_1e46c3b11dbc
name: ACOX1
has only substance units: false
boundary condition: true
initial amount: NaN
is: SBO:0000252
initial concentration: NaN
type: Species
is encoded by: hsa:51
constant: false
is: Q15067

metaR FAOXC165C164m
kinetic law: MODEL1310110045#
product: MODEL1310110045#
reactant: MODEL1310110045#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation (C16:5-->C16:4)m
type: Reaction

metaR VLCS2p
modifier: MODEL1310110045#
is described by: ECO:0000304
reversible: false
name: Very-long-chain-fatty-acid-CoA ligase
is: SBO:0000176
type: Reaction
notes: GENE_ASSOCIATION: (11001.1) SUBSYSTEM: Bile acid synthesis EC Number: 6.2.1.7 Confidence Level: 2 AUTHORS: PMID:10479480 NOTES:from uniprot and lit - see human recon lit refs divalent cation requirement - unclear which one, reaction inhibited in the presence of EDTA (may just be MgATP or MgATP) - see Kelley and Vessey Biochimica et Biophysica Acta (1994) 1209: 51-55 temporarily will have H+ balance reaction NJ
reactant: MODEL1310110045#
fast: false
kinetic law: MODEL1310110045#
product: MODEL1310110045#
is version of: http://identifiers.org/ec-code/6.2.1.3

metaM csn c
is: SBO:0000247
boundary condition: false
constant: false
name: cytosine
notes: FORMULA: C4H5N3O CHARGE: 0 INCHI: InChI=1S/C4H5N3O/c5-3-1-2-6-4(8)7-3/h1-2H,(H3,5,6,7,8)
is: HMDB00630
has only substance units: false
type: Species
initial amount: NaN
initial concentration: 1.0
is: CHEBI:16040

metaR INSTt4 2
modifier: MODEL1310110045#
fast: false
product: MODEL1310110045#
kinetic law: MODEL1310110045#
notes: GENE_ASSOCIATION: (115584.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12039040,PMID:12133831 NOTES:NCD
reversible: true
is: SBO:0000185
reactant: MODEL1310110045#
name: inositol transport via sodium symport
is described by: ECO:0000006
type: Reaction

metaR CYTK14
fast: false
name: cytidylate kinase (dCMP,UTP)
is version of: http://identifiers.org/ec-code/2.7.4.14
reactant: MODEL1310110045#
reversible: true
product: MODEL1310110045#
is: SBO:0000176
type: Reaction
is described by: ECO:0000269
modifier: MODEL1310110045#
kinetic law: MODEL1310110045#
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:

metaM ksi deg11 l
is: HMDB00143
constant: false
notes: FORMULA: C180H289N12O158S9 CHARGE: -9
has only substance units: false
name: keratan sulfate I, degradation product 11
boundary condition: false
initial concentration: 1.0
initial amount: NaN
is: CHEBI:12936
is: SBO:0000247
type: Species

http://identifiers.org/biomodels.db/MODEL1310110045#_4ab7ec9f_58df_4a26_83c4_0f20c9ede462
type: Species
initial concentration: NaN
constant: false
has part: A8K7W0
is: SBO:0000297
name: VNN3:VNN2:VNN1
boundary condition: true
is encoded by: hsa:55350
initial amount: NaN
has part: O95497
is encoded by: hsa:8875
has only substance units: false
is encoded by: hsa:8876

http://identifiers.org/biomodels.db/MODEL1310110045#_a34e634a_08d1_48bf_90dd_e6cee01cbbfe
has only substance units: false
boundary condition: true
is: O75355
name: ENTPD3
is: SBO:0000252
initial concentration: NaN
constant: false
initial amount: NaN
is encoded by: hsa:956
type: Species

metaR r2124
modifier: MODEL1310110045#
product: MODEL1310110045#
fast: false
is: SBO:0000185
reactant: MODEL1310110045#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
is described by: ECO:0000000
reversible: true
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
type: Reaction
kinetic law: MODEL1310110045#

metaM HC01118 r
notes: FORMULA: C30H49O7P2 CHARGE: -3 INCHI: InChI=1S/C30H52O7P2/c1-23(2)13-9-15-25(5)17-11-18-27(7)21-28-29(22-36-39(34,35)37-38(31,32)33)30(28,8)20-12-19-26(6)16-10-14-24(3)4/h13-14,17,19,21,28-29H,9-12,15-16,18,20,22H2,1-8H3,(H,34,35)(H2,31,32,33)/p-3/b25-17+,26-19+,27-21+/t28-,29-,30-/m0/s1 EHMN_ABBREVIATION: C03428
name: presqualene diphosphate(3-)
has only substance units: false
is: CHEBI:57310
initial amount: NaN
initial concentration: 1.0
is: SBO:0000247
boundary condition: false
type: Species
constant: false

metaR MECOAS1m
kinetic law: MODEL1310110045#
notes: GENE_ASSOCIATION: (8802.1 and 8801.1) SUBSYSTEM: C5-branched dibasic acid metabolism EC Number: 6.2.1.4 Confidence Level: 2 AUTHORS: PMID:13783048 NOTES:IF
is described by: ECO:0000304
fast: false
reactant: MODEL1310110045#
is: SBO:0000176
name: mesaconate--CoA ligase (GDP-forming)
modifier: MODEL1310110045#
product: MODEL1310110045#
is version of: http://identifiers.org/ec-code/6.2.1.4
type: Reaction
reversible: true

metaM HC02180 c
initial concentration: 1.0
has only substance units: false
constant: false
is: CHEBI:28728
type: Species
initial amount: NaN
boundary condition: false
is: SBO:0000247
name: thromboxane-b2
notes: FORMULA: C20H33O6 CHARGE: -1 INCHI: InChI=1S/C20H34O6/c1-2-3-6-9-15(21)12-13-18-16(17(22)14-20(25)26-18)10-7-4-5-8-11-19(23)24/h4,7,12-13,15-18,20-22,25H,2-3,5-6,8-11,14H2,1H3,(H,23,24)/b7-4-,13-12+/t15-,16-,17-,18+,20?/m0/s1 EHMN_ABBREVIATION: C05963

http://identifiers.org/biomodels.db/MODEL1310110045#_021d366e_ba76_431d_9651_c5ed3d3a416a
type: Species
name: B3GNT4
is encoded by: hsa:79369
initial concentration: NaN
is: Q9C0J1
constant: false
boundary condition: true
is: SBO:0000252
initial amount: NaN
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110045#_792b1280_4ff3_47bd_9798_e3494c30ede1
constant: false
is: Q8IWX5
initial concentration: NaN
is: SBO:0000252
name: SGPP2
has only substance units: false
initial amount: NaN
type: Species
boundary condition: true
is encoded by: hsa:130367

http://identifiers.org/biomodels.db/MODEL1310110045#_1e3979e3_4960_407f_8865_57bfc199ef6d
name: ST3GAL1
initial amount: NaN
is: SBO:0000252
initial concentration: NaN
boundary condition: true
is encoded by: hsa:6482
type: Species
constant: false
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110045#_206973e5_d574_4c3f_a483_28ba5c1d16ba
initial concentration: NaN
constant: false
is: P06865
type: Species
boundary condition: true
is: SBO:0000252
name: HEXA
has only substance units: false
is encoded by: hsa:3073
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110045#_7d4a78bf_535e_4804_a259_6e9bfcb66d97
has only substance units: false
is: P33908
is: SBO:0000252
constant: false
name: MAN1A1
type: Species
is encoded by: hsa:4121
boundary condition: true
initial amount: NaN
initial concentration: NaN

metaR DHFR
kinetic law: MODEL1310110045#
reversible: true
name: dihydrofolate reductase
is version of: http://identifiers.org/ec-code/1.5.1.3
modifier: MODEL1310110045#
is described by: ECO:0000254
fast: false
is: SBO:0000176
reactant: MODEL1310110045#
product: MODEL1310110045#
type: Reaction
notes: GENE_ASSOCIATION: (1719.1) SUBSYSTEM: Folate metabolism EC Number: 1.5.1.3 Confidence Level: 2 AUTHORS: PMID:6504041 NOTES:

metaR MANtg
name: mannose efflux from Golgi apparatus
is described by: ECO:0000000
fast: false
product: MODEL1310110045#
reactant: MODEL1310110045#
type: Reaction
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD
reversible: false
kinetic law: MODEL1310110045#

metaM CE4790 m
initial concentration: 1.0
has only substance units: false
is: SBO:0000247
constant: false
name: (3S)-3-hydroxy-cis-8-tetradecenoyl-CoA
is: CHEBI:57923
boundary condition: false
initial amount: NaN
type: Species
notes: FORMULA: C35H56N7O18P3S CHARGE: -4 INCHI: InChI=1/C35H60N7O18P3S/c1-4-5-6-7-8-9-10-11-12-13-23(43)18-26(45)64-17-16-37-25(44)14-15-38-33(48)30(47)35(2,3)20-57-63(54,55)60-62(52,53)56-19-24-29(59-61(49,50)51)28(46)34(58-24)42-22-41-27-31(36)39-21-40-32(27)42/h8-9,21-24,28-30,34,43,46-47H,4-7,10-20H2,1-3H3,(H,37,44)(H,38,48)(H,52,53)(H,54,55)(H2,36,39,40)(H2,49,50,51)/p-4/b9-8-/t23-,24-,28+,29+,30u,34-/m0/s1 EHMN_ABBREVIATION: CE4790

metaR DINt
is: SBO:0000185
kinetic law: MODEL1310110045#
name: deoxyinosine transport via diffusion
fast: false
is described by: ECO:0000000
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10899995 NOTES:
type: Reaction
product: MODEL1310110045#
reactant: MODEL1310110045#

metaR MACOXO
reactant: MODEL1310110045#
type: Reaction
notes: GENE_ASSOCIATION: (218.1) or (221.1) or (4129.1) or (222.1) or (220.1) SUBSYSTEM: Histidine metabolism EC Number: 1.2.1.5 Confidence Level: 4 AUTHORS: PMID:10344773 NOTES:SAB added 2 h to balance--not certain
reversible: false
is version of: http://identifiers.org/ec-code/1.4.3.4
fast: false
product: MODEL1310110045#
is: SBO:0000176
modifier: MODEL1310110045#
is version of: http://identifiers.org/ec-code/1.2.1.5
name: 3-Methylimidazole acetaldehyde:NAD+ oxidoreductase
is described by: ECO:0000269
kinetic law: MODEL1310110045#

metaR r2127
is: SBO:0000185
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
reversible: true
fast: false
kinetic law: MODEL1310110045#
type: Reaction
product: MODEL1310110045#
reactant: MODEL1310110045#
is described by: ECO:0000000
modifier: MODEL1310110045#

http://identifiers.org/biomodels.db/MODEL1310110045#_1e9f8a4c_95c2_444a_844d_fdb75e87b160
initial concentration: NaN
has only substance units: false
is encoded by: hsa:4702
constant: false
is: SBO:0000252
type: Species
name: NDUFA8
boundary condition: true
is: B1AM93
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110045#_dca028f0_0515_407d_8c4b_ef59963681c1
initial concentration: NaN
name: PCBD2
initial amount: NaN
is: Q9H0N5
boundary condition: true
is: SBO:0000252
constant: false
is encoded by: hsa:84105
type: Species
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110045#_d39e259c_e45d_4f29_946f_64be537c5cb5
initial concentration: NaN
is: O14561
is encoded by: hsa:4706
initial amount: NaN
type: Species
has only substance units: false
boundary condition: true
constant: false
is: SBO:0000252
name: NDUFAB1

http://identifiers.org/biomodels.db/MODEL1310110045#_940d1bf9_7837_4472_9186_2094b0cda3c7
has only substance units: false
boundary condition: true
initial concentration: NaN
type: Species
constant: false
name: RDH12
is: Q96NR8
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:145226

metaR GCC2bim
reversible: false
type: Reaction
product: MODEL1310110045#
fast: false
reactant: MODEL1310110045#
is version of: http://identifiers.org/ec-code/2.1.2.10
is version of: http://identifiers.org/ec-code/1.8.1.4
is version of: http://identifiers.org/ec-code/1.4.4.2
kinetic law: MODEL1310110045#
is described by: ECO:0000269
name: glycine-cleavage system (lipoamide) irreversible, mitochondrial
is: SBO:0000176
modifier: MODEL1310110045#
notes: GENE_ASSOCIATION: (275.1) and (1738.1) and (2731.1) and (2653.1) SUBSYSTEM: Glycine, serine, alanine and threonine metabolism EC Number: 1.8.1.4 Confidence Level: 4 AUTHORS: PMID:15355973 NOTES:NCD

metaR D LACt2
type: Reaction
product: MODEL1310110045#
kinetic law: MODEL1310110045#
name: D-lactate transport via proton symport
reversible: true
is: SBO:0000185
reactant: MODEL1310110045#
notes: GENE_ASSOCIATION: (9194.1) or (23539.1) or (6566.1) or (9123.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10493836,PMID:10510291,PMID:11101640,PMID:12739169,PMID:7835905,PMID:8476015,PMID:9425115,PMID:9508842,PMID:9649795,PMID:9786900,PMID:9824713 NOTES:JLR
is described by: ECO:0000269
fast: false
modifier: MODEL1310110045#

http://identifiers.org/biomodels.db/MODEL1310110045#_05312b51_7904_43ca_b702_1b18bebcb296
is: Q16698
has only substance units: false
is: SBO:0000252
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:1666
boundary condition: true
type: Species
constant: false
name: DECR1

metaM HC02180 e
is: SBO:0000247
boundary condition: false
name: thromboxane-b2
has only substance units: false
initial concentration: 1.0
type: Species
constant: false
notes: FORMULA: C20H33O6 CHARGE: -1 INCHI: InChI=1S/C20H34O6/c1-2-3-6-9-15(21)12-13-18-16(17(22)14-20(25)26-18)10-7-4-5-8-11-19(23)24/h4,7,12-13,15-18,20-22,25H,2-3,5-6,8-11,14H2,1H3,(H,23,24)/b7-4-,13-12+/t15-,16-,17-,18+,20?/m0/s1 EHMN_ABBREVIATION: C05963
initial amount: NaN
is: CHEBI:28728

http://identifiers.org/biomodels.db/MODEL1310110045#_bbf7bfa9_1486_4830_bc74_3fb9b8450ff6
name: ND4
is: SBO:0000252
initial concentration: NaN
has only substance units: false
type: Species
boundary condition: true
is: P03905
initial amount: NaN
is encoded by: hsa:4538
constant: false

metaM prostgi2 r
notes: FORMULA: C20H31O5 CHARGE: -1 INCHI: InChI=1S/C20H32O5/c1-2-3-4-7-14(21)10-11-16-17-12-15(8-5-6-9-20(23)24)25-19(17)13-18(16)22/h8,10-11,14,16-19,21-22H,2-7,9,12-13H2,1H3,(H,23,24)/p-1/b11-10+,15-8-/t14-,16+,17+,18+,19-/m0/s1 EHMN_ABBREVIATION: C01312
is: CHEBI:57403
initial concentration: 1.0
is: SBO:0000247
name: prostaglandin I2(1-)
is: HMDB01335
constant: false
boundary condition: false
has only substance units: false
type: Species
initial amount: NaN

metaR r0994
name: Facilitated diffusion
reactant: MODEL1310110045#
kinetic law: MODEL1310110045#
is described by: ECO:0000000
fast: false
is: SBO:0000185
product: MODEL1310110045#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:15975683 NOTES:
type: Reaction
reversible: true

metaM CE2420 m
initial amount: NaN
name: (3S)-3-hydroxydodec-cis-6-enoyl-CoA
has only substance units: false
constant: false
is: SBO:0000247
initial concentration: 1.0
is: CHEBI:28387
type: Species
boundary condition: false
notes: FORMULA: C33H52N7O18P3S CHARGE: -4 INCHI: InChI=1/C33H56N7O18P3S/c1-4-5-6-7-8-9-10-11-21(41)16-24(43)62-15-14-35-23(42)12-13-36-31(46)28(45)33(2,3)18-55-61(52,53)58-60(50,51)54-17-22-27(57-59(47,48)49)26(44)32(56-22)40-20-39-25-29(34)37-19-38-30(25)40/h8-9,19-22,26-28,32,41,44-45H,4-7,10-18H2,1-3H3,(H,35,42)(H,36,46)(H,50,51)(H,52,53)(H2,34,37,38)(H2,47,48,49)/p-4/b9-8-/t21-,22-,26+,27+,28u,32-/m0/s1 EHMN_ABBREVIATION: CE2420
is: HMDB11123

metaR r2126
fast: false
product: MODEL1310110045#
kinetic law: MODEL1310110045#
is: SBO:0000185
is described by: ECO:0000000
reversible: true
type: Reaction
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
reactant: MODEL1310110045#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
modifier: MODEL1310110045#

metaR VD3
is described by: ECO:0000134
fast: false
name: Vitamin D3 formation
product: MODEL1310110045#
reactant: MODEL1310110045#
kinetic law: MODEL1310110045#
notes: GENE_ASSOCIATION: SUBSYSTEM: Vitamin D metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:8392061 NOTES:This reaction takes place in skin and needs body temperature based on Vitamins, G.F.M. Ball,2004, Blackwell publishing, 1st ed (book) pg.194 IT
type: Reaction
reversible: true
is: SBO:0000176

metaM HC02193 e
initial concentration: 1.0
constant: false
has only substance units: false
boundary condition: false
notes: FORMULA: C26H42NO4 CHARGE: -1 INCHI: InChI=1S/C26H43NO4/c1-16(4-9-23(29)27-15-24(30)31)20-7-8-21-19-6-5-17-14-18(28)10-12-25(17,2)22(19)11-13-26(20,21)3/h16-22,28H,4-15H2,1-3H3,(H,27,29)(H,30,31)/p-1/t16-,17-,18-,19+,20-,21+,22+,25+,26-/m1/s1
type: Species
name: glycolithocholate
is: CHEBI:60008
is: SBO:0000247
initial amount: NaN

metaR RETH1e
name: retinyl ester hydrolase (9-cis), extracellular
is described by: ECO:0000000
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Vitamin A metabolism EC Number: Confidence Level: 2 AUTHORS: PMID:1503811 NOTES:IT
product: MODEL1310110045#
type: Reaction
reversible: false
reactant: MODEL1310110045#
fast: false
kinetic law: MODEL1310110045#

metaM fad e
has only substance units: false
initial amount: NaN
is: C00016
constant: false
name: Flavin adenine dinucleotide oxidized
is: SBO:0000247
type: Species
boundary condition: false
is: CHEBI:16238
notes: FORMULA: C27H31N9O15P2 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00026 EHMN_ABBREVIATION: C00016
initial concentration: 1.0
is: HMDB01248

metaM arach c
boundary condition: false
notes: FORMULA: C20H39O2 CHARGE: -1 INCHI: InChI=1S/C20H40O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20(21)22/h2-19H2,1H3,(H,21,22)/p-1 EHMN_ABBREVIATION: CE0102
name: arachidate
type: Species
initial concentration: 1.0
constant: false
is: SBO:0000247
is: HMDB02212
initial amount: NaN
has only substance units: false
is: CHEBI:32360

http://identifiers.org/biomodels.db/MODEL1310110045#_52d57961_41ab_4b60_baab_9806df8421ea
name: PIK3C3
constant: false
type: Species
initial concentration: NaN
has only substance units: false
is encoded by: hsa:5289
boundary condition: true
is: SBO:0000252
is: Q8NEB9
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110045#_8401f2db_fe01_4838_92ac_70e0d978b7fc
is: SBO:0000252
name: NDUFA1
type: Species
boundary condition: true
is encoded by: hsa:4694
initial amount: NaN
constant: false
initial concentration: NaN
is: Q6IBB5
has only substance units: false

metaR NDPK6n
is version of: http://identifiers.org/ec-code/2.7.4.6
modifier: MODEL1310110045#
is described by: ECO:0000304
reversible: true
is: SBO:0000176
kinetic law: MODEL1310110045#
notes: GENE_ASSOCIATION: (4831.1 and 4830.1) or (4830.2 and 4831.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.6 Confidence Level: 4 AUTHORS: PMID:7050910 NOTES:Many nucleoside diphosphates (eight described) can act as acceptors. While many ribo- and deoxyribonucleoside triphosphates can act as donors, only ATP is chosen as a donor to minimize the number of total reactions.. Presence in the nucleus
fast: false
type: Reaction
reactant: MODEL1310110045#
name: nucleoside-diphosphate kinase (ATP:dUDP), nuclear
product: MODEL1310110045#

metaR ADAe
is: SBO:0000176
kinetic law: MODEL1310110045#
fast: false
modifier: MODEL1310110045#
notes: GENE_ASSOCIATION: (100.1) SUBSYSTEM: Purine catabolism EC Number: 3.5.4.4 Confidence Level: 4 AUTHORS: PMID:12381379,PMID:15016824 NOTES:adenosine deaminase has been found on cell surface in human (Gonzales-Gronow et al, JBC, 2004,279,20993-20998). IT
reversible: false
name: Adenosine deaminase, extracellular
is version of: http://identifiers.org/ec-code/3.5.4.4
is described by: ECO:0000269
product: MODEL1310110045#
reactant: MODEL1310110045#
type: Reaction

metaM acetone m
name: acetone
initial concentration: 1.0
constant: false
has only substance units: false
is: HMDB01659
notes: FORMULA: C3H6O CHARGE: 0 INCHI: InChI=1S/C3H6O/c1-3(2)4/h1-2H3 HEPATONET_1.0_ABBREVIATION: HC00193 EHMN_ABBREVIATION: C00207
is: SBO:0000247
initial amount: NaN
boundary condition: false
is: CHEBI:15347
type: Species

http://identifiers.org/biomodels.db/MODEL1310110045#_61a9996b_aade_4b66_b712_8fa97644fece
is: Q9BZW2
initial concentration: NaN
type: Species
is encoded by: hsa:6561
constant: false
is: SBO:0000252
name: SLC13A1
boundary condition: true
has only substance units: false
initial amount: NaN

metaM 13 cis retn r
is: HMDB06219
name: 13-cis-retinoate
is: http://identifiers.org/pubchem.compound/7847414
initial concentration: 1.0
boundary condition: false
initial amount: NaN
notes: FORMULA: C20H27O2 CHARGE: -1 INCHI: InChI=1/C20H28O2/c1-15(8-6-9-16(2)14-19(21)22)11-12-18-17(3)10-7-13-20(18,4)5/h6,8-9,11-12,14H,7,10,13H2,1-5H3,(H,21,22)/b9-6+,12-11+,15-8+,16-14- EHMN_ABBREVIATION: CE2952
type: Species
constant: false
is: SBO:0000247
is: D00348
has only substance units: false

metaM dtmp c
type: Species
notes: FORMULA: C10H13N2O8P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00308 EHMN_ABBREVIATION: C00364
is: HMDB01227
initial concentration: 1.0
has only substance units: false
initial amount: NaN
constant: false
boundary condition: false
is: CHEBI:26999
is: SBO:0000247
is: C00364
name: dTMP

metaR r2129
modifier: MODEL1310110045#
reversible: true
fast: false
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
type: Reaction
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
reactant: MODEL1310110045#
is described by: ECO:0000000
kinetic law: MODEL1310110045#
product: MODEL1310110045#
is: SBO:0000185

metaR RPI
is version of: http://identifiers.org/ec-code/5.3.1.6
reversible: true
reactant: MODEL1310110045#
kinetic law: MODEL1310110045#
name: ribose-5-phosphate isomerase
product: MODEL1310110045#
notes: GENE_ASSOCIATION: (22934.1) SUBSYSTEM: Pentose phosphate pathway EC Number: 5.3.1.6 Confidence Level: 0 AUTHORS: NOTES:SMP
type: Reaction
is: SBO:0000176
is described by: ECO:0000000
modifier: MODEL1310110045#
fast: false

http://identifiers.org/biomodels.db/MODEL1310110045#_e3f02d54_8c18_48d7_befc_d1cc41964e80
initial amount: NaN
is encoded by: hsa:10993
boundary condition: true
name: SDS
constant: false
has only substance units: false
is: SBO:0000252
is: P20132
type: Species
initial concentration: NaN

metaM Rtotal3coa c
has only substance units: false
is: HMDB01448
is: CHEBI:16189
is: SBO:0000247
constant: false
initial amount: NaN
notes: FORMULA: CO2FULLR3C21H31N7O15P3S CHARGE: -4
name: R total 3 Coenzyme A
boundary condition: false
type: Species
initial concentration: 1.0

metaR NACHEXA19ly
is described by: ECO:0000000
name: beta-N-acetylhexosaminidase A, lysosomal
product: MODEL1310110045#
is version of: http://identifiers.org/ec-code/3.2.1.52
fast: false
reactant: MODEL1310110045#
type: Reaction
is: SBO:0000176
modifier: MODEL1310110045#
kinetic law: MODEL1310110045#
reversible: false
notes: GENE_ASSOCIATION: (3073.1) or (3073.1 and 3074.1) SUBSYSTEM: Keratan sulfate degradation EC Number: Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12706724,PMID:8993162 NOTES:Note that this reaction is specific to beta-N-acetylhexosaminidase A and cannot be catalyzed by beta-N-acetylhexosaminidase B (or presumably beta-N-acetylhexosaminidase S). This is also a lumped reaction, representing the cleavage of GalNAc4S or GalNAc6S and N-acetylgalactosamine 4-sulfatase or 6-sulfatase. NCD

metaM guln c
initial amount: NaN
is: CHEBI:13115
is: HMDB03290
is: SBO:0000247
name: L-gulonate
boundary condition: false
constant: false
notes: FORMULA: C6H11O7 CHARGE: -1 INCHI: InChI=1S/C6H12O7/c7-1-2(8)3(9)4(10)5(11)6(12)13/h2-5,7-11H,1H2,(H,12,13)/p-1/t2-,3+,4-,5-/m0/s1 EHMN_ABBREVIATION: C00800
type: Species
has only substance units: false
initial concentration: 1.0

metaM arach e
is: SBO:0000247
notes: FORMULA: C20H39O2 CHARGE: -1 INCHI: InChI=1S/C20H40O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20(21)22/h2-19H2,1H3,(H,21,22)/p-1 EHMN_ABBREVIATION: CE0102
is: HMDB02212
boundary condition: false
has only substance units: false
constant: false
initial concentration: 1.0
type: Species
name: arachidate
initial amount: NaN
is: CHEBI:32360

metaR PROSTGF2t
reversible: true
kinetic law: MODEL1310110045#
fast: false
product: MODEL1310110045#
name: prostaglandin uniport
is: SBO:0000185
notes: GENE_ASSOCIATION: (6582.2) or (6582.1) or (6580.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12827517,PMID:12883891,PMID:9187257 NOTES:electrogenic, Na indepdendent & rev NJ
type: Reaction
reactant: MODEL1310110045#
is described by: ECO:0000269
modifier: MODEL1310110045#

metaR r2128
type: Reaction
is: SBO:0000185
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
fast: false
kinetic law: MODEL1310110045#
modifier: MODEL1310110045#
product: MODEL1310110045#
reactant: MODEL1310110045#
reversible: true

metaM fad c
is: SBO:0000247
type: Species
name: Flavin adenine dinucleotide oxidized
has only substance units: false
initial amount: NaN
notes: FORMULA: C27H31N9O15P2 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00026 EHMN_ABBREVIATION: C00016
is: HMDB01248
is: CHEBI:16238
initial concentration: 1.0
boundary condition: false
is: C00016
constant: false

metaM cholcoar x
initial amount: NaN
initial concentration: 1.0
name: (25R)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-oyl-CoA(4-)
is: CHEBI:58677
notes: FORMULA: C48H76N7O20P3S CHARGE: -4 INCHI: InChI=1S/C48H80N7O20P3S/c1-25(29-10-11-30-36-31(20-34(58)48(29,30)6)47(5)14-12-28(56)18-27(47)19-32(36)57)8-7-9-26(2)45(63)79-17-16-50-35(59)13-15-51-43(62)40(61)46(3,4)22-72-78(69,70)75-77(67,68)71-21-33-39(74-76(64,65)66)38(60)44(73-33)55-24-54-37-41(49)52-23-53-42(37)55/h23-34,36,38-40,44,56-58,60-61H,7-22H2,1-6H3,(H,50,59)(H,51,62)(H,67,68)(H,69,70)(H2,49,52,53)(H2,64,65,66)/p-4/t25-,26-,27+,28-,29-,30+,31+,32-,33-,34+,36+,38-,39-,40+,44-,47+,48-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01348 EHMN_ABBREVIATION: C04760
constant: false
is: HMDB02178
boundary condition: false
is: SBO:0000247
type: Species
has only substance units: false

metaM pi x
boundary condition: false
notes: FORMULA: HO4P CHARGE: -2 INCHI: InChI=1S/H3O4P/c1-5(2,3)4/h(H3,1,2,3,4)/p-2 HEPATONET_1.0_ABBREVIATION: HC00019 EHMN_ABBREVIATION: C00009
name: hydrogenphosphate
is: SBO:0000247
type: Species
initial concentration: 1.0
constant: false
is: HMDB00973
is: CHEBI:43474
has only substance units: false
initial amount: NaN

metaM g3m8mpdol L r
notes: FORMULA: C1960H3228N20O770P20 CHARGE: -20
is: HMDB01342
boundary condition: false
initial concentration: 1.0
initial amount: NaN
is: SBO:0000247
has only substance units: false
name: (alpha-D-Glucosyl)3-(alpha-D-mannosyl)8-beta-D-mannosyl-diacetylchitobiosyldiphosphodolichol, human liver homolog
type: Species
is: C00459
is: CHEBI:37568
constant: false

metaR MI13PP
type: Reaction
fast: false
reversible: false
is described by: ECO:0000000
product: MODEL1310110045#
reactant: MODEL1310110045#
is: SBO:0000176
kinetic law: MODEL1310110045#
notes: GENE_ASSOCIATION: SUBSYSTEM: Inositol phosphate metabolism EC Number: 3.1.3.64 Confidence Level: 2 AUTHORS: PMID:2906139 NOTES:NCD
name: inositol-1,3-bisphosphate 3-phosphatase

metaM dcsptn1crn m
boundary condition: false
type: Species
notes: FORMULA: C29H47NO4 CHARGE: 0 INCHI: InChI=1/C29H47NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-24-29(33)34-27(25-28(31)32)26-30(2,3)4/h9-10,12-13,15-16,18-19,21-22,27H,5-8,11,14,17,20,23-26H2,1-4H3/b10-9+,13-12+,16-15+,19-18+,22-21+
is: SBO:0000247
name: docosa-4,7,10,13,16-pentaenoyl carnitine
is: HMDB06321
initial amount: NaN
initial concentration: 1.0
has only substance units: false
constant: false

metaR NDPK10n
type: Reaction
fast: false
reversible: true
product: MODEL1310110045#
reactant: MODEL1310110045#
notes: GENE_ASSOCIATION: (4831.1 and 4830.1) or (4830.2 and 4831.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.6 Confidence Level: 4 AUTHORS: PMID:7050910 NOTES:Many nucleoside diphosphates (eight described) can act as acceptors. While many ribo- and deoxyribonucleoside triphosphates can act as donors, only ATP is chosen as a donor to minimize the number of total reactions. . Presence in the nucleus
is version of: http://identifiers.org/ec-code/2.7.4.6
is: SBO:0000176
is described by: ECO:0000304
modifier: MODEL1310110045#
kinetic law: MODEL1310110045#
name: nucleoside-diphosphate kinase (ATP:dIDP), nuclear

metaR PRPNCOAHYDm
modifier: MODEL1310110045#
notes: GENE_ASSOCIATION: (1892.1) or (3030.1) and (3032.1) or (549.1) SUBSYSTEM: beta-Alanine metabolism EC Number: 4.2.1.17 Confidence Level: 1 AUTHORS: PMID:8824301 NOTES:SAB made up name because name in KEGG seemed wrong. in vitro assay
fast: false
is described by: ECO:0000134
reversible: false
is version of: http://identifiers.org/ec-code/4.2.1.17
is: SBO:0000176
is version of: http://identifiers.org/ec-code/4.2.1.18
is version of: http://identifiers.org/ec-code/2.3.1.16
name: Propenoyl-CoA hydrolase (m)
reactant: MODEL1310110045#
product: MODEL1310110045#
type: Reaction
kinetic law: MODEL1310110045#

http://identifiers.org/biomodels.db/MODEL1310110045#_dec8a106_dff1_4eb8_94c7_803a1da7539e
name: PISD
boundary condition: true
initial amount: NaN
is encoded by: hsa:23761
is: SBO:0000252
type: Species
initial concentration: NaN
is: Q9UG56
constant: false
has only substance units: false

metaR PEt
is described by: ECO:0000000
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11591435,PMID:12814641,PMID:15599942,PMID:1679347,PMID:7487879,PMID:8188243 NOTES:
name: phosphatidylethanolamine transport
fast: false
reactant: MODEL1310110045#
kinetic law: MODEL1310110045#
type: Reaction
is: SBO:0000185
product: MODEL1310110045#

http://identifiers.org/biomodels.db/MODEL1310110045#_949c3412_0c2d_4415_9cdb_6363cdca0f5c
is: Q6YFQ2
has only substance units: false
initial amount: NaN
name: COX6B2
is encoded by: hsa:125965
initial concentration: NaN
type: Species
constant: false
is: SBO:0000252
boundary condition: true

metaR r0999
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:1735445,PMID:18406340,PMID:1988962,PMID:2351134,PMID:2355017,PMID:6361812,PMID:7892212,PMID:8132483 NOTES:
fast: false
reversible: true
reactant: MODEL1310110045#
type: Reaction
is: SBO:0000185
name: Facilitated diffusion
kinetic law: MODEL1310110045#
product: MODEL1310110045#

http://identifiers.org/biomodels.db/MODEL1310110045#_cea7c85b_9aa4_4872_bbb2_8403d95ba04f
boundary condition: true
name: SLC35A2
initial amount: NaN
type: Species
is: P78381
constant: false
is: SBO:0000252
is encoded by: hsa:7355
has only substance units: false
initial concentration: NaN

metaM 4abutn m
notes: FORMULA: C4H10NO CHARGE: 1 INCHI: InChI=1S/C4H9NO/c5-3-1-2-4-6/h4H,1-3,5H2/p+1 HEPATONET_1.0_ABBREVIATION: HC00428 EHMN_ABBREVIATION: C00555
is: CHEBI:58264
constant: false
is: SBO:0000247
initial amount: NaN
initial concentration: 1.0
boundary condition: false
name: 4-ammoniobutanal
is: HMDB01080
type: Species
has only substance units: false

metaM HC00229 e
type: Species
notes: FORMULA: C12H22O11 CHARGE: 0 INCHI: InChI=1S/C12H22O11/c13-1-4(15)7(17)8(18)5(16)3-22-12-11(21)10(20)9(19)6(2-14)23-12/h1,4-12,14-21H,2-3H2/t4-,5+,6+,7+,8+,9+,10-,11+,12-/m0/s1 EHMN_ABBREVIATION: C00252
name: Isomaltose
has only substance units: false
initial concentration: 1.0
is: SBO:0000247
initial amount: NaN
constant: false
is: CHEBI:28189
boundary condition: false

metaM xol27oh m
has only substance units: false
type: Species
is: CHEBI:17703
boundary condition: false
is: SBO:0000247
name: 26-hydroxycholesterol
is: HMDB02103
initial amount: NaN
initial concentration: 1.0
notes: FORMULA: C27H46O2 CHARGE: 0 INCHI: InChI=1S/C27H46O2/c1-18(17-28)6-5-7-19(2)23-10-11-24-22-9-8-20-16-21(29)12-14-26(20,3)25(22)13-15-27(23,24)4/h8,18-19,21-25,28-29H,5-7,9-17H2,1-4H3/t18?,19-,21+,22+,23-,24+,25+,26+,27-/m1/s1 EHMN_ABBREVIATION: C06340
constant: false

metaR SUCOASm
is: SBO:0000176
fast: false
name: Succinate--CoA ligase (ADP-forming)
modifier: MODEL1310110045#
reactant: MODEL1310110045#
is version of: http://identifiers.org/ec-code/6.2.1.4
type: Reaction
product: MODEL1310110045#
is version of: http://identifiers.org/ec-code/6.2.1.5
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (8802.1 and 8803.1) SUBSYSTEM: Citric acid cycle EC Number: 6.2.1.5 Confidence Level: 0 AUTHORS: PMID:9765291 NOTES:MIPS: cofactor ATP IF changed EC from 6.2.1.4 to 6.2.1.5 - NCD
kinetic law: MODEL1310110045#
reversible: true

metaR PYNP2r
notes: GENE_ASSOCIATION: (7378.2) or (151531.1) or (7378.1) SUBSYSTEM: Pyrimidine catabolism EC Number: 2.4.2.2 Confidence Level: 4 AUTHORS: PMID:11278417,PMID:12084455,PMID:12849978,PMID:7488099 NOTES:JLR- added reversible form of PYNP2
is: SBO:0000176
reactant: MODEL1310110045#
fast: false
is described by: ECO:0000269
name: pyrimidine-nucleoside phosphorylase (uracil)
product: MODEL1310110045#
kinetic law: MODEL1310110045#
type: Reaction
is version of: http://identifiers.org/ec-code/2.4.2.3
modifier: MODEL1310110045#
reversible: true

metaR HGNTOR
is: SBO:0000176
modifier: MODEL1310110045#
is version of: http://identifiers.org/ec-code/1.13.11.5
is described by: ECO:0000269
name: Homogentisate:oxygen 1,2-oxidoreductase (decyclizing)
notes: GENE_ASSOCIATION: (3081.1) SUBSYSTEM: Tyrosine metabolism EC Number: 1.13.11.5 Confidence Level: 4 AUTHORS: NOTES:
reactant: MODEL1310110045#
fast: false
reversible: false
type: Reaction
product: MODEL1310110045#
kinetic law: MODEL1310110045#

metaM dtmp e
is: HMDB01227
initial amount: NaN
constant: false
has only substance units: false
is: CHEBI:26999
initial concentration: 1.0
name: dTMP(2-)
type: Species
boundary condition: false
notes: FORMULA: C10H13N2O8P CHARGE: -2 INCHI: InChI=1S/C10H15N2O8P/c1-5-3-12(10(15)11-9(5)14)8-2-6(13)7(20-8)4-19-21(16,17)18/h3,6-8,13H,2,4H2,1H3,(H,11,14,15)(H2,16,17,18)/p-2/t6-,7+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00308 EHMN_ABBREVIATION: C00364
is: SBO:0000247

metaR ALA DASH DTDe
type: Reaction
name: exit of D-alanine from the enterocytes
fast: false
is: SBO:0000185
is described by: ECO:0000134
reversible: false
kinetic law: MODEL1310110045#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 1 AUTHORS: no specific transporter for exit of D-alanine could be found, so diffusion mechanism is assumed. NOTES:no specific transporter for exit of D-alanine could be found, so diffusion mechanism is assumed.
product: MODEL1310110045#
reactant: MODEL1310110045#

metaR r0998
reactant: MODEL1310110045#
is: SBO:0000185
is described by: ECO:0000000
name: Facilitated diffusion
kinetic law: MODEL1310110045#
product: MODEL1310110045#
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:1735445,PMID:18406340,PMID:1988962,PMID:2351134,PMID:2355017,PMID:6361812,PMID:7892212,PMID:8132483 NOTES:
type: Reaction
fast: false

metaR GCC2am
modifier: MODEL1310110045#
name: glycine-cleavage complex (lipoamide), mitochondrial
type: Reaction
kinetic law: MODEL1310110045#
product: MODEL1310110045#
notes: GENE_ASSOCIATION: (275.1) and (1738.1) and (2731.1) and (2653.1) SUBSYSTEM: Glycine, serine, alanine and threonine metabolism EC Number: 2.1.2.10 Confidence Level: 4 AUTHORS: PMID:15355973 NOTES:NCD
reactant: MODEL1310110045#
is version of: http://identifiers.org/ec-code/1.8.1.4
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.1.2.10
is version of: http://identifiers.org/ec-code/1.4.4.2
fast: false
is described by: ECO:0000269
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110045#_f2ef80f8_71d7_4ad0_b1db_5a5e62e32721
has only substance units: false
boundary condition: true
name: GLRX2
is: SBO:0000252
type: Species
is: Q9NS18
initial concentration: NaN
constant: false
is encoded by: hsa:51022
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110045#_1d2d3e77_7e26_4de5_9aff_eed6ec362267
has part: O00459
has part: P42336
type: Species
constant: false
is: SBO:0000297
name: PIK3CA:PIK3R2
initial concentration: NaN
is encoded by: hsa:5296
initial amount: NaN
is encoded by: hsa:5290
has only substance units: false
boundary condition: true

metaR r0202
reactant: MODEL1310110045#
reversible: true
kinetic law: MODEL1310110045#
product: MODEL1310110045#
is: SBO:0000176
is described by: ECO:0000000
type: Reaction
fast: false
name: sn-Glycerol-3-phosphate:NAD+ 2-oxidoreductase Glycerophospholipid metabolism EC:1.1.1.8
notes: GENE_ASSOCIATION: SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: 1.1.1.8 Confidence Level: 0 AUTHORS: PMID:17045662,PMID:7772607 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110045#_97ebb410_7f72_4beb_a19a_1f212c6bfa70
is: Q05C14
initial concentration: NaN
constant: false
is: SBO:0000252
has only substance units: false
is encoded by: hsa:2352
name: FOLR3
type: Species
boundary condition: true
initial amount: NaN

metaM dgdp m
type: Species
notes: FORMULA: C10H12N5O10P2 CHARGE: -3 INCHI: InChI=1S/C10H15N5O10P2/c11-10-13-8-7(9(17)14-10)12-3-15(8)6-1-4(16)5(24-6)2-23-27(21,22)25-26(18,19)20/h3-6,16H,1-2H2,(H,21,22)(H2,18,19,20)(H3,11,13,14,17)/p-3/t4-,5+,6+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00305 EHMN_ABBREVIATION: C00361
name: dGDP(2-)
initial amount: NaN
boundary condition: false
is: HMDB00960
has only substance units: false
constant: false
is: CHEBI:58595
is: SBO:0000247
initial concentration: 1.0

metaM ksii core4 pre2 g
name: keratan sulfate II boisynthesis, precursor 2
initial amount: NaN
has only substance units: false
is: SBO:0000247
is: HMDB00175
initial concentration: 1.0
is: C00130
type: Species
is: CHEBI:58053
boundary condition: false
notes: FORMULA: C47H76N4O33X CHARGE: -1
constant: false

metaR DM 4abut LPAREN n RPAREN
kinetic law: MODEL1310110045#
reactant: MODEL1310110045#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: PMID: 16643338 NOTES:GABA in the intestine may aid in differentiation and proliferation of epithelial cells. GABA intake by oral administration has been shown to alleviate stress, worry and anxiety and additionally it can also improve human immunity (PMID: 16971751). However the PAT1 transporter located at the apical side of enterocytes have very low affinity for GABA. I have presumed that this oral GABA is used within intestine (unless administered at high very high pharmacological doses, GABA exit from the enterocytes may be mediated by other specifc transporters).
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: Demand for 4-Aminobutanoate(n)
type: Reaction

metaM psyl e
has only substance units: false
notes: FORMULA: C9642006H15428700O8667414 CHARGE: 0
is: http://identifiers.org/pubchem.compound/94244
is: SBO:0000247
initial concentration: 1.0
boundary condition: false
constant: false
initial amount: NaN
type: Species
name: psyllium

metaR RE1342C
type: Reaction
is described by: ECO:0000000
name: RE1342
reversible: true
is: SBO:0000176
fast: false
reactant: MODEL1310110045#
notes: GENE_ASSOCIATION: SUBSYSTEM: Fructose and mannose metabolism EC Number: 1.1.1.21 Confidence Level: 0 AUTHORS: PMID:9537432 NOTES:IT - fixed proton
kinetic law: MODEL1310110045#
product: MODEL1310110045#

http://identifiers.org/biomodels.db/MODEL1310110045#_ccd6e403_611d_42f7_84c2_2ab467b6489b
type: Species
is: F8W682
initial amount: NaN
has only substance units: false
constant: false
boundary condition: true
is: SBO:0000252
name: SLC4A2
initial concentration: NaN
is encoded by: hsa:6522

http://identifiers.org/biomodels.db/MODEL1310110045#_7e2ddb65_9035_4658_b76b_d8119002ac15
name: RFK
type: Species
is encoded by: hsa:55312
initial concentration: NaN
constant: false
is: SBO:0000252
boundary condition: true
is: B2RDZ2
has only substance units: false
initial amount: NaN

metaR GLYtp
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: PMID:15240345 NOTES:TDV
name: glycine passive transport to peroxisome
product: MODEL1310110045#
reactant: MODEL1310110045#
is: SBO:0000185
is described by: ECO:0000000
reversible: true
type: Reaction
kinetic law: MODEL1310110045#

http://identifiers.org/biomodels.db/MODEL1310110045#_e2fc7e97_a164_46b6_99dc_130fe165c77e
is: SBO:0000252
is encoded by: hsa:AF080579
has only substance units: false
boundary condition: true
constant: false
name: _AF080579_1_c
initial amount: NaN
initial concentration: NaN
type: Species

metaR DHPM1
is: SBO:0000176
modifier: MODEL1310110045#
reactant: MODEL1310110045#
name: dihydropyrimidinase (5,6-dihydrouracil)
product: MODEL1310110045#
is version of: http://identifiers.org/ec-code/3.5.2.2
reversible: false
fast: false
type: Reaction
is described by: ECO:0000269
kinetic law: MODEL1310110045#
notes: GENE_ASSOCIATION: (1807.1) or (1809.1) or (1808.1) SUBSYSTEM: Pyrimidine catabolism EC Number: 3.5.2.2 Confidence Level: 4 AUTHORS: PMID:8973361 NOTES:

metaM dgdp n
initial amount: NaN
is: CHEBI:58595
initial concentration: 1.0
has only substance units: false
constant: false
notes: FORMULA: C10H12N5O10P2 CHARGE: -3 INCHI: InChI=1S/C10H15N5O10P2/c11-10-13-8-7(9(17)14-10)12-3-15(8)6-1-4(16)5(24-6)2-23-27(21,22)25-26(18,19)20/h3-6,16H,1-2H2,(H,21,22)(H2,18,19,20)(H3,11,13,14,17)/p-3/t4-,5+,6+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00305 EHMN_ABBREVIATION: C00361
is: SBO:0000247
boundary condition: false
is: HMDB00960
type: Species
name: dGDP(2-)

metaR r1179
reversible: false
product: MODEL1310110045#
is described by: ECO:0000000
name: EC:3.1.1.13
type: Reaction
reactant: MODEL1310110045#
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 3.1.1.13 Confidence Level: 0 AUTHORS: PMID:11230747,PMID:8112342 NOTES:
is: SBO:0000176
fast: false
kinetic law: MODEL1310110045#

metaR FMNAT
is: SBO:0000176
notes: GENE_ASSOCIATION: (80308.1) or (80308.2) SUBSYSTEM: Vitamin B2 metabolism EC Number: 2.7.7.2 Confidence Level: 2 AUTHORS: PMID:16643857,PMID:17049878 NOTES:Human Y/N: Y
modifier: MODEL1310110045#
name: FMN adenylyltransferase
fast: false
product: MODEL1310110045#
reversible: false
is described by: ECO:0000134
is version of: http://identifiers.org/ec-code/2.7.7.2
reactant: MODEL1310110045#
kinetic law: MODEL1310110045#
type: Reaction

metaM HC02193 c
initial amount: NaN
is: SBO:0000247
type: Species
is: CHEBI:60008
boundary condition: false
name: glycolithocholate
has only substance units: false
initial concentration: 1.0
constant: false
notes: FORMULA: C26H42NO4 CHARGE: -1 INCHI: InChI=1S/C26H43NO4/c1-16(4-9-23(29)27-15-24(30)31)20-7-8-21-19-6-5-17-14-18(28)10-12-25(17,2)22(19)11-13-26(20,21)3/h16-22,28H,4-15H2,1-3H3,(H,27,29)(H,30,31)/p-1/t16-,17-,18-,19+,20-,21+,22+,25+,26-/m1/s1

http://identifiers.org/biomodels.db/MODEL1310110045#_780613a5_c244_4fa3_ab3d_d67457fa068e
is encoded by: hsa:108
has only substance units: false
constant: false
is: Q71UM8
is: SBO:0000252
type: Species
name: ADCY2
initial amount: NaN
initial concentration: NaN
boundary condition: true

metaM pail3p hs c
type: Species
is: SBO:0000247
name: 1-phosphatidyl-1D-myo-inositol 3-phosphate(3-)
initial amount: NaN
has only substance units: false
initial concentration: 1.0
is: CHEBI:58088
notes: FORMULA: C9H15O12P2FULLRCO2FULLR2CO2 CHARGE: -3 EHMN_ABBREVIATION: C04549
constant: false
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110045#_fe0ba20f_5203_4b7c_a0e7_453238e211f3
initial concentration: NaN
has only substance units: false
is encoded by: hsa:27124
is: Q15735
is: SBO:0000252
boundary condition: true
initial amount: NaN
type: Species
constant: false
name: INPP5J

metaR ADRNCOAtx
type: Reaction
is described by: ECO:0000000
reactant: MODEL1310110045#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: NOTES:interaction between peroxisomes and ER (some enzymes on the outer membrane) NJ
product: MODEL1310110045#
reversible: true
fast: false
name: fatty acid intracellular transport
kinetic law: MODEL1310110045#
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110045#_76f3fe11_d029_4bd0_a3ad_d49bbc42cbc8
boundary condition: true
constant: false
name: NDUFB4
initial amount: NaN
initial concentration: NaN
has only substance units: false
type: Species
is: O95168
is: SBO:0000252
is encoded by: hsa:4710

http://identifiers.org/biomodels.db/MODEL1310110045#_a899031b_b71f_480b_8df0_ba9e7128a0f1
boundary condition: true
has only substance units: false
initial amount: NaN
initial concentration: NaN
is: SBO:0000252
is: P00813
type: Species
is encoded by: hsa:100
constant: false
name: ADA

metaM ksi pre22 g
is: HMDB00175
is: SBO:0000247
constant: false
initial concentration: 1.0
notes: FORMULA: C185H297N13O150S6X CHARGE: -7
is: C00130
is: CHEBI:58053
type: Species
has only substance units: false
boundary condition: false
name: keratan sulfate I biosynthesis, precursor 22
initial amount: NaN

metaR FAOXC163C164Gm
kinetic law: MODEL1310110045#
product: MODEL1310110045#
reactant: MODEL1310110045#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C16:3-->C16:4)gm
type: Reaction

metaR RE3000M
notes: GENE_ASSOCIATION: (1891.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 0 AUTHORS: PMID:10407780,PMID:7775433 NOTES:
is: SBO:0000176
kinetic law: MODEL1310110045#
fast: false
is described by: ECO:0000000
reversible: true
name: RE3000
reactant: MODEL1310110045#
product: MODEL1310110045#
modifier: MODEL1310110045#
type: Reaction

metaR FAOXC185m
kinetic law: MODEL1310110045#
product: MODEL1310110045#
reactant: MODEL1310110045#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: isomerization(C18:5)m
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110045#_8800c026_8c7c_4f94_9631_968c7c56c411
constant: false
initial amount: NaN
is encoded by: hsa:7083
boundary condition: true
type: Species
has only substance units: false
name: TK1
is: SBO:0000252
is: P04183
initial concentration: NaN

metaR DAGK hs
modifier: MODEL1310110045#
notes: GENE_ASSOCIATION: (9162.1) or (1607.1) or (8525.2) or (160851.1) or (1608.1) or (1607.2) or (8525.1) or (8527.1) or (1606.1) or (160851.2) or (8526.1) or (8525.3) or (1607.1) or (8527.2) or (1609.1) SUBSYSTEM: Glycerophospholipid metabolism EC Number: 2.7.1.107 Confidence Level: 4 AUTHORS: NOTES:NJ
is described by: ECO:0000269
name: Diacylglycerol phosphate kinase (homo sapiens)
kinetic law: MODEL1310110045#
is version of: http://identifiers.org/ec-code/2.7.1.107
reversible: true
product: MODEL1310110045#
is: SBO:0000176
reactant: MODEL1310110045#
type: Reaction
fast: false

metaR EX tymsf LPAREN e RPAREN
kinetic law: MODEL1310110045#
reactant: MODEL1310110045#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Tyramine O-sulfate exchange
type: Reaction

metaR ADSK
product: MODEL1310110045#
notes: GENE_ASSOCIATION: (9060.1) or (9061.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.1.25 Confidence Level: 4 AUTHORS: PMID:11931637,PMID:12716056 NOTES:
is version of: http://identifiers.org/ec-code/2.7.1.25
name: adenylyl-sulfate kinase
type: Reaction
fast: false
is described by: ECO:0000269
kinetic law: MODEL1310110045#
is: SBO:0000176
modifier: MODEL1310110045#
reversible: false
reactant: MODEL1310110045#

metaR r2334
is: SBO:0000185
kinetic law: MODEL1310110045#
reactant: MODEL1310110045#
type: Reaction
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
reversible: true
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
product: MODEL1310110045#
is described by: ECO:0000000

metaR PAPStg
kinetic law: MODEL1310110045#
product: MODEL1310110045#
type: Reaction
notes: GENE_ASSOCIATION: (347734.1) SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 4 AUTHORS: PMID:12716889 NOTES:NCD
modifier: MODEL1310110045#
reactant: MODEL1310110045#
is: SBO:0000185
is described by: ECO:0000269
fast: false
name: 3'-Phosphoadenylyl sufate Golgi transport
reversible: true

metaM lnlnca e
has only substance units: false
constant: false
boundary condition: false
is: CHEBI:32387
type: Species
initial amount: NaN
initial concentration: 1.0
notes: FORMULA: C18H29O2 CHARGE: -1 INCHI: InChI=1S/C18H30O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20/h3-4,6-7,9-10H,2,5,8,11-17H2,1H3,(H,19,20)/p-1/b4-3-,7-6-,10-9-
name: alpha-linolenate
is: SBO:0000247
is: HMDB01388

http://identifiers.org/biomodels.db/MODEL1310110045#_29c4c2a6_0be2_4b67_8c7a_aca3bff87387
name: ACAA1
is encoded by: hsa:30
is: SBO:0000252
boundary condition: true
is: Q96CA6
has only substance units: false
initial concentration: NaN
constant: false
type: Species
initial amount: NaN

metaM 2obut c
is: CHEBI:16763
initial amount: NaN
name: 2-Oxobutanoate
type: Species
is: SBO:0000247
is: C00109
initial concentration: 1.0
has only substance units: false
is: HMDB00005
constant: false
boundary condition: false
notes: FORMULA: C4H5O3 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00108 EHMN_ABBREVIATION: C00109

metaR NACHEXA3ly
modifier: MODEL1310110045#
reversible: false
reactant: MODEL1310110045#
is described by: ECO:0000000
type: Reaction
is version of: http://identifiers.org/ec-code/3.2.1.52
name: beta-N-acetylhexosaminidase A, lysosomal
fast: false
notes: GENE_ASSOCIATION: (3073.1) or (3073.1 and 3074.1) SUBSYSTEM: Chondroitin sulfate degradation EC Number: Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12706724,PMID:8993162 NOTES:Note that this reaction is specific to beta-N-acetylhexosaminidase A and cannot be catalyzed by beta-N-acetylhexosaminidase B (or presumably beta-N-acetylhexosaminidase S). This is also a lumped reaction, representing the cleavage of GalNAc4S or GalNAc6S and N-acetylgalactosamine 4-sulfatase or 6-sulfatase. NCD
product: MODEL1310110045#
kinetic law: MODEL1310110045#
is: SBO:0000176

metaR KSIt
name: keratan sulfate I transport, golgi to extracellular
kinetic law: MODEL1310110045#
product: MODEL1310110045#
is: SBO:0000185
reversible: false
type: Reaction
is described by: ECO:0000000
fast: false
reactant: MODEL1310110045#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:NCD

http://identifiers.org/biomodels.db/MODEL1310110045#_22bb74bf_a50b_4dd6_a89c_1b5078c976eb
initial amount: NaN
initial concentration: NaN
constant: false
type: Species
name: LDHA
boundary condition: true
is encoded by: hsa:3939
is: P00338
has only substance units: false
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110045#_38138d01_0322_4462_bf02_29735eea0ffe
is encoded by: hsa:218
initial amount: NaN
boundary condition: true
type: Species
is: P30838
initial concentration: NaN
is: SBO:0000252
has only substance units: false
constant: false
name: ALDH3A1

metaR O2Stm
name: superoxide anion transport via diffusion (mitochondria)
product: MODEL1310110045#
type: Reaction
is described by: ECO:0000000
reactant: MODEL1310110045#
is: SBO:0000185
reversible: true
fast: false
kinetic law: MODEL1310110045#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: PMID:12939409 NOTES:

metaR r2335
type: Reaction
reversible: true
is: SBO:0000185
kinetic law: MODEL1310110045#
is described by: ECO:0000000
reactant: MODEL1310110045#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
product: MODEL1310110045#

http://identifiers.org/biomodels.db/MODEL1310110045#_814109fd_6416_46e1_8b75_e0387c402734
has only substance units: false
is: E7EPT3
boundary condition: true
initial concentration: NaN
name: ALDH7A1
is encoded by: hsa:501
initial amount: NaN
constant: false
type: Species
is: SBO:0000252

metaR PPD2CSPp
is described by: ECO:0000000
name: PPD2CSPp
fast: false
product: MODEL1310110045#
reversible: false
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Lysine metabolism EC Number: Confidence Level: 2 AUTHORS: PMID:10485319,PMID:10772957 NOTES:spontaneous cyclization reaction MM
is: SBO:0000176
reactant: MODEL1310110045#
kinetic law: MODEL1310110045#

http://identifiers.org/biomodels.db/MODEL1310110045#_9bf261df_9727_4099_81e8_5fef7b29fcbf
initial concentration: NaN
is encoded by: hsa:377677
has only substance units: false
boundary condition: true
is: Q8N1Q1
constant: false
type: Species
initial amount: NaN
is: SBO:0000252
name: CA13

metaM fad m
is: C00016
type: Species
constant: false
is: SBO:0000247
notes: FORMULA: C27H31N9O15P2 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00026 EHMN_ABBREVIATION: C00016
is: CHEBI:16238
initial concentration: 1.0
is: HMDB01248
has only substance units: false
initial amount: NaN
boundary condition: false
name: Flavin adenine dinucleotide oxidized

metaM HC00250 e
name: hydrosulfide
initial amount: NaN
type: Species
boundary condition: false
initial concentration: 1.0
constant: false
has only substance units: false
is: SBO:0000247
notes: FORMULA: HS CHARGE: -1 INCHI: InChI=1S/H2S/h1H2/p-1 EHMN_ABBREVIATION: C00283
is: CHEBI:29919

metaR EX val L LPAREN e RPAREN
kinetic law: MODEL1310110045#
reactant: MODEL1310110045#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: L-Valine exchange
type: Reaction

metaR r2332
kinetic law: MODEL1310110045#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
is: SBO:0000185
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
reversible: true
fast: false
reactant: MODEL1310110045#
type: Reaction
product: MODEL1310110045#
is described by: ECO:0000000

metaM adn c
is: C00212
name: Adenosine
is: SBO:0000247
initial concentration: 1.0
notes: FORMULA: C10H13N5O4 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00196 EHMN_ABBREVIATION: C00212
constant: false
is: CHEBI:16335
boundary condition: false
initial amount: NaN
is: HMDB00050
has only substance units: false
type: Species

metaR r0647
is: SBO:0000176
type: Reaction
kinetic law: MODEL1310110045#
product: MODEL1310110045#
is described by: ECO:0000000
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Tryptophan metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:18124509,PMID:6027578 NOTES:
reactant: MODEL1310110045#
name: Spontaneous reaction
reversible: true

metaR S6T11g
product: MODEL1310110045#
is described by: ECO:0000000
modifier: MODEL1310110045#
reversible: false
fast: false
name: galactose/N-acetylglucosamine 6-O-sulfotransferase, Golgi apparatus
reactant: MODEL1310110045#
kinetic law: MODEL1310110045#
is: SBO:0000176
notes: GENE_ASSOCIATION: (23563.2) or (9435.1) or (23563.1) or (10164.1) or (4166.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: Confidence Level: 4 AUTHORS: PMID:10330415,PMID:10491328,PMID:10913333,PMID:11278593,PMID:12403612,PMID:12855678,PMID:9722682 NOTES:NCD
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110045#_ca7aa304_22ea_42e7_b7b9_fa12d30ddb71
has only substance units: false
is: O43488
constant: false
name: AKR7A2
type: Species
initial concentration: NaN
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:8574
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110045#_3075a967_a7c8_47bf_96ff_075b15c3c8d3
is encoded by: hsa:84693
initial concentration: NaN
constant: false
boundary condition: true
name: MCEE
has only substance units: false
is: SBO:0000252
is: Q96PE7
type: Species
initial amount: NaN

metaR ASNtm
name: L-asparagine transport, mitochondrial
is described by: ECO:0000000
reactant: MODEL1310110045#
kinetic law: MODEL1310110045#
fast: false
type: Reaction
reversible: false
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: NOTES:TDV
product: MODEL1310110045#

metaR PGK
product: MODEL1310110045#
modifier: MODEL1310110045#
fast: false
is described by: ECO:0000134
is version of: http://identifiers.org/ec-code/2.7.2.3
notes: GENE_ASSOCIATION: (5230.1) or (375056.1) or (5232.1) SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: Confidence Level: 0 AUTHORS: NOTES:
type: Reaction
name: phosphoglycerate kinase
is: SBO:0000176
reversible: true
reactant: MODEL1310110045#
kinetic law: MODEL1310110045#

metaR ACCOAC
kinetic law: MODEL1310110045#
product: MODEL1310110045#
reactant: MODEL1310110045#
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: false
name: acetyl-CoA carboxylase
type: Reaction

metaM cytd c
notes: FORMULA: C9H13N3O5 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00381 EHMN_ABBREVIATION: C00475
name: Cytidine
is: SBO:0000247
boundary condition: false
has only substance units: false
initial amount: NaN
constant: false
is: CHEBI:17562
initial concentration: 1.0
is: HMDB00089
is: C00475
type: Species

metaR r2333
reversible: true
type: Reaction
kinetic law: MODEL1310110045#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
is: SBO:0000185
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
is described by: ECO:0000000
fast: false
reactant: MODEL1310110045#
product: MODEL1310110045#

metaR r0434
product: MODEL1310110045#
modifier: MODEL1310110045#
notes: GENE_ASSOCIATION: (AI824319.1) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.21 Confidence Level: 0 AUTHORS: PMID:1735445,PMID:1988962,PMID:2355017,PMID:6361812,PMID:7892212 NOTES:
kinetic law: MODEL1310110045#
is: SBO:0000176
name: Palmitoyl-CoA:L-carnitine O-palmitoyltransferase Fatty acid metabolism EC:2.3.1.21
type: Reaction
is described by: ECO:0000000
reversible: true
reactant: MODEL1310110045#
fast: false

http://identifiers.org/biomodels.db/MODEL1310110045#_0ba6b5d8_2491_4652_a863_49e3b075f0ea
constant: false
type: Species
initial concentration: NaN
boundary condition: true
is encoded by: hsa:284273
name: ZADH2
is: Q8N4Q0
is: SBO:0000252
has only substance units: false
initial amount: NaN

metaM dpcoa m
is: HMDB01373
is: SBO:0000247
initial amount: NaN
name: 3'-dephospho-CoA(2-)
has only substance units: false
initial concentration: 1.0
type: Species
notes: FORMULA: C21H33N7O13P2S CHARGE: -2 INCHI: InChI=1S/C21H35N7O13P2S/c1-21(2,16(32)19(33)24-4-3-12(29)23-5-6-44)8-39-43(36,37)41-42(34,35)38-7-11-14(30)15(31)20(40-11)28-10-27-13-17(22)25-9-26-18(13)28/h9-11,14-16,20,30-32,44H,3-8H2,1-2H3,(H,23,29)(H,24,33)(H,34,35)(H,36,37)(H2,22,25,26)/p-2/t11-,14-,15-,16+,20-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00575 EHMN_ABBREVIATION: C00882
is: CHEBI:57328
constant: false
boundary condition: false

metaR r2338
name: Major Facilitator(MFS) TCDB:2.A.1.19.1
reactant: MODEL1310110045#
kinetic law: MODEL1310110045#
product: MODEL1310110045#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12883891 NOTES:
is: SBO:0000185
is described by: ECO:0000000
reversible: true
fast: false
type: Reaction

metaM fald c
notes: FORMULA: CH2O CHARGE: 0 INCHI: InChI=1S/CH2O/c1-2/h1H2 HEPATONET_1.0_ABBREVIATION: HC00070 EHMN_ABBREVIATION: C00067
initial concentration: 1.0
boundary condition: false
name: formaldehyde
type: Species
initial amount: NaN
is: CHEBI:16842
is: SBO:0000247
constant: false
has only substance units: false
is: HMDB01426

metaM dec24dicoa m
notes: FORMULA: C31H46N7O17P3S CHARGE: -4
has only substance units: false
constant: false
boundary condition: false
is: HMDB01168
initial concentration: 1.0
name: 2,4-decadienoylcoa
initial amount: NaN
type: Species
is: SBO:0000247

metaM h2o2 x
name: Hydrogen peroxide
boundary condition: false
initial concentration: 1.0
initial amount: NaN
is: C00027
type: Species
is: HMDB03125
is: SBO:0000247
notes: FORMULA: H2O2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00036 EHMN_ABBREVIATION: C00027
has only substance units: false
is: CHEBI:16240
constant: false

metaM HC02175 e
type: Species
constant: false
boundary condition: false
is: SBO:0000247
notes: FORMULA: C10H19O2 CHARGE: -1 INCHI: InChI=1S/C10H20O2/c1-2-3-4-5-6-7-8-9-10(11)12/h2-9H2,1H3,(H,11,12)/p-1
is: CHEBI:27689
initial amount: NaN
has only substance units: false
initial concentration: 1.0
name: caprate

metaR G14T3g
notes: GENE_ASSOCIATION: (8703.1) or (2683.1) or (8704.2) or (8704.1) or (9334.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.38 Confidence Level: 4 AUTHORS: PMID:12512857,PMID:1903938,PMID:3094506,PMID:3144273,PMID:9405390,PMID:9435216 NOTES:Keratan sulfate II biosynthesis NCD
reversible: false
is version of: http://identifiers.org/ec-code/2.4.1.90
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.4.1.22
reactant: MODEL1310110045#
name: beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase, Golgi
fast: false
is described by: ECO:0000000
kinetic law: MODEL1310110045#
type: Reaction
modifier: MODEL1310110045#
product: MODEL1310110045#
is version of: http://identifiers.org/ec-code/2.4.1.38

metaR FAOXC164m
kinetic law: MODEL1310110045#
product: MODEL1310110045#
reactant: MODEL1310110045#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: isomerization(C16:4)m
type: Reaction

metaM HC00250 c
name: hydrosulfide
type: Species
is: SBO:0000247
is: CHEBI:29919
initial concentration: 1.0
constant: false
initial amount: NaN
boundary condition: false
notes: FORMULA: HS CHARGE: -1 INCHI: InChI=1S/H2S/h1H2/p-1 EHMN_ABBREVIATION: C00283
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110045#_8c5e817c_598a_4a20_840a_3c429dd0b80a
is encoded by: hsa:107
initial concentration: NaN
is: Q08828
type: Species
initial amount: NaN
has only substance units: false
is: SBO:0000252
boundary condition: true
name: ADCY1
constant: false

metaM CE1943 e
constant: false
has only substance units: false
initial concentration: 1.0
is: CHEBI:30623
boundary condition: false
initial amount: NaN
is: SBO:0000247
is: HMDB02329
type: Species
notes: FORMULA: C7H14NO2 CHARGE: 1 INCHI: InChI=1/C7H13NO2/c9-6-2-1-4-8-5-3-7-10/h6-8H,1-5H2/p+1 EHMN_ABBREVIATION: CE1943
name: spermidine dialdehyde

metaM adprbp e
type: Species
has only substance units: false
name: ADP-D-ribose 2'-phosphate(4-)
notes: FORMULA: C15H20N5O17P3 CHARGE: -4 INCHI: InChI=1S/C15H24N5O17P3/c16-12-7-13(18-3-17-12)20(4-19-7)14-11(35-38(25,26)27)9(23)6(33-14)2-32-39(28,29)37-40(30,31)36-15-10(24)8(22)5(1-21)34-15/h3-6,8-11,14-15,21-24H,1-2H2,(H,28,29)(H,30,31)(H2,16,17,18)(H2,25,26,27)/p-4/t5-,6-,8-,9-,10-,11-,14-,15?/m1/s1 EHMN_ABBREVIATION: C03246
boundary condition: false
initial amount: NaN
is: CHEBI:58673
initial concentration: 1.0
is: SBO:0000247
is: HMDB06336
constant: false

http://identifiers.org/biomodels.db/MODEL1310110045#_233dcb69_397d_4e75_83b8_4fee57bfb70a
initial concentration: NaN
boundary condition: true
initial amount: NaN
name: LDHAL6B
is: Q9BYZ2
is: SBO:0000252
has only substance units: false
type: Species
constant: false
is encoded by: hsa:92483

metaM adn e
is: C00212
constant: false
is: SBO:0000247
is: HMDB00050
initial amount: NaN
name: Adenosine
is: CHEBI:16335
initial concentration: 1.0
notes: FORMULA: C10H13N5O4 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00196 EHMN_ABBREVIATION: C00212
type: Species
boundary condition: false
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110045#_ed3bd06f_6dc5_4677_9533_ffe13ffada9e
name: GGH
constant: false
has only substance units: false
initial amount: NaN
initial concentration: NaN
boundary condition: true
is encoded by: hsa:8836
is: Q92820
is: SBO:0000252
type: Species

http://identifiers.org/biomodels.db/MODEL1310110045#_54da3996_2037_4d11_8d9e_fe6fe5302296
boundary condition: true
name: _AI435857_1_x
initial concentration: NaN
has only substance units: false
initial amount: NaN
is: SBO:0000252
is encoded by: hsa:AI435857
constant: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110045#_1e600a18_1381_465d_92f2_b523e792c401
initial amount: NaN
name: SLC25A2
boundary condition: true
is: SBO:0000252
is: Q9BXI2
has only substance units: false
type: Species
initial concentration: NaN
constant: false
is encoded by: hsa:83884

metaR OAADC
kinetic law: MODEL1310110045#
product: MODEL1310110045#
reactant: MODEL1310110045#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: oxaloacetate decarboxylase
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110045#_ffe1fcd4_1dc6_4c79_8b75_3234b44ed4ac
initial concentration: NaN
type: Species
initial amount: NaN
name: ACAA2
boundary condition: true
is: SBO:0000252
is encoded by: hsa:10449
constant: false
has only substance units: false
is: P42765

metaR S6T9g
type: Reaction
reactant: MODEL1310110045#
fast: false
modifier: MODEL1310110045#
is: SBO:0000176
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (23563.2) or (9435.1) or (23563.1) or (10164.1) or (4166.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: Confidence Level: 4 AUTHORS: PMID:10330415,PMID:10491328,PMID:10913333,PMID:11278593,PMID:12403612,PMID:12855678,PMID:9722682 NOTES:NCD
name: galactose/N-acetylglucosamine 6-O-sulfotransferase, Golgi apparatus
product: MODEL1310110045#
reversible: false
kinetic law: MODEL1310110045#

metaR NTP3e
product: MODEL1310110045#
is: SBO:0000176
reversible: false
fast: false
is version of: http://identifiers.org/ec-code/3.6.1.6
name: nucleoside-triphosphatase (GTP)
modifier: MODEL1310110045#
reactant: MODEL1310110045#
type: Reaction
kinetic law: MODEL1310110045#
notes: GENE_ASSOCIATION: (124583.1) SUBSYSTEM: Nucleotide interconversion EC Number: 3.6.1.15 Confidence Level: 4 AUTHORS: PMID:12234496,PMID:12600208 NOTES:
is described by: ECO:0000269

metaM malt e
is: SBO:0000247
is: CHEBI:17306
initial amount: NaN
type: Species
constant: false
name: Maltose
is: C00208
notes: FORMULA: C12H22O11 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00194 EHMN_ABBREVIATION: C00208
is: HMDB00163
boundary condition: false
has only substance units: false
initial concentration: 1.0

metaR NRPPHRSULT
is: SBO:0000176
fast: false
notes: GENE_ASSOCIATION: (6818.1) or (6818.3) or (6818.2) SUBSYSTEM: Tyrosine metabolism EC Number: 2.8.2.1 Confidence Level: 4 AUTHORS: PMID:11535246,PMID:15293241 NOTES:RS/TV (6/14/05)
kinetic law: MODEL1310110045#
product: MODEL1310110045#
is version of: http://identifiers.org/ec-code/2.8.2.1
name: Norepinephrine Sulfotransferase
reactant: MODEL1310110045#
is described by: ECO:0000269
reversible: false
modifier: MODEL1310110045#
type: Reaction

metaM HC00591 m
has only substance units: false
name: 2-oxoglutaramate
type: Species
initial concentration: 1.0
constant: false
notes: FORMULA: C5H6NO4 CHARGE: -1 INCHI: InChI=1S/C5H7NO4/c6-4(8)2-1-3(7)5(9)10/h1-2H2,(H2,6,8)(H,9,10)/p-1 EHMN_ABBREVIATION: C00940
boundary condition: false
is: SBO:0000247
initial amount: NaN
is: CHEBI:16769

metaM ksi pre2 g
is: SBO:0000247
boundary condition: false
is: HMDB00175
constant: false
name: keratan sulfate I biosynthesis, precursor 2
initial amount: NaN
type: Species
notes: FORMULA: C87H142N6O62X CHARGE: -1
initial concentration: 1.0
has only substance units: false
is: CHEBI:58053
is: C00130

http://identifiers.org/biomodels.db/MODEL1310110045#_aa9dda81_f815_4661_9344_9379aa5eeefc
has only substance units: false
boundary condition: true
initial concentration: NaN
constant: false
initial amount: NaN
type: Species
name: ST6GAL1
is: SBO:0000252
is encoded by: hsa:6480

metaM HC02175 c
has only substance units: false
is: SBO:0000247
name: caprate
type: Species
is: CHEBI:27689
boundary condition: false
initial amount: NaN
notes: FORMULA: C10H19O2 CHARGE: -1 INCHI: InChI=1S/C10H20O2/c1-2-3-4-5-6-7-8-9-10(11)12/h2-9H2,1H3,(H,11,12)/p-1
constant: false
initial concentration: 1.0

metaM sphings c
is: HMDB00252
notes: FORMULA: C18H38NO2 CHARGE: 1 INCHI: InChI=1S/C18H37NO2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-18(21)17(19)16-20/h14-15,17-18,20-21H,2-13,16,19H2,1H3/p+1/b15-14+/t17-,18+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00271 EHMN_ABBREVIATION: C00319
boundary condition: false
has only substance units: false
constant: false
initial amount: NaN
initial concentration: 1.0
is: SBO:0000247
type: Species
is: CHEBI:57756
name: sphingosine(1+)

http://identifiers.org/biomodels.db/MODEL1310110045#_405dc12f_db00_47d1_9da8_d701780ab7c0
type: Species
initial concentration: NaN
constant: false
initial amount: NaN
name: ALG5
is: Q9Y673
boundary condition: true
is: SBO:0000252
is encoded by: hsa:29880
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110045#_6ecde8a6_4ba4_4848_b61d_eda05b2fc0a4
type: Species
initial concentration: NaN
is encoded by: hsa:AL048840
initial amount: NaN
is: SBO:0000252
has only substance units: false
name: _AL048840_1_c
constant: false
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110045#_2e03c2e1_c6d8_432c_9764_83929e11a88d
boundary condition: true
is: SBO:0000252
type: Species
initial concentration: NaN
has only substance units: false
name: ADSS
is: P30520
constant: false
is encoded by: hsa:159
initial amount: NaN

metaR SQLSr
type: Reaction
is: SBO:0000176
name: Squalene synthase
reactant: MODEL1310110045#
notes: GENE_ASSOCIATION: (2222.1) SUBSYSTEM: Cholesterol metabolism EC Number: 2.5.1.21 Confidence Level: 4 AUTHORS: PMID:1318747 NOTES:This is a lumped reaction: Rxn 1: 2 frdp -> 2 ppi + presqualene diphosphate Rxn 2: presqualene diphosphate + NADPH -> squalene + NADP NCD ER version - NJ
fast: false
modifier: MODEL1310110045#
is version of: http://identifiers.org/ec-code/2.5.1.21
kinetic law: MODEL1310110045#
product: MODEL1310110045#
reversible: false
is described by: ECO:0000134

metaM retfa e
initial concentration: 1.0
constant: false
initial amount: NaN
is: SBO:0000247
has only substance units: false
notes: FORMULA: C20H29OFULLR2CO CHARGE: 0
name: fatty acid retinol
is: CHEBI:15963
is: HMDB00508
boundary condition: false
type: Species

metaR r0531
product: MODEL1310110045#
kinetic law: MODEL1310110045#
name: dUTP:cytidine 5-phosphotransferase Pyrimidine metabolism EC:2.7.1.48
is: SBO:0000176
modifier: MODEL1310110045#
reactant: MODEL1310110045#
is version of: http://identifiers.org/ec-code/1.1.1.34
type: Reaction
is described by: ECO:0000000
fast: false
reversible: true
notes: GENE_ASSOCIATION: (3156.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.1.48 Confidence Level: 0 AUTHORS: PMID:11306702,PMID:9923963 NOTES:

metaR GALASE18ly
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/3.2.1.23
is version of: http://identifiers.org/ec-code/3.2.1.18
type: Reaction
fast: false
name: beta-galactosidase, lysosomal
is version of: http://identifiers.org/ec-code/3.1.6.4
is: SBO:0000176
reactant: MODEL1310110045#
modifier: MODEL1310110045#
kinetic law: MODEL1310110045#
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) or (5476.1) and (2720.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.23 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD
reversible: false
product: MODEL1310110045#
is version of: http://identifiers.org/ec-code/3.4.16.5

metaR DCK2n
name: Deoxycytidine kinase, nuclear (UTP)
notes: GENE_ASSOCIATION: (1633.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.1.74 Confidence Level: 4 AUTHORS: PMID:10387103,PMID:12535661,PMID:9342341 NOTES:IT (2.7.1.74)
type: Reaction
kinetic law: MODEL1310110045#
is: SBO:0000176
modifier: MODEL1310110045#
is version of: http://identifiers.org/ec-code/2.7.1.74
reversible: true
fast: false
reactant: MODEL1310110045#
is described by: ECO:0000269
product: MODEL1310110045#

metaR r0644
is: SBO:0000176
type: Reaction
product: MODEL1310110045#
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 1.2.3.1 Confidence Level: 0 AUTHORS: PMID:11569919,PMID:16143537 NOTES:
is described by: ECO:0000000
name: (S)-Methylmalonate semialdehyde:oxygen oxidoreductase Valine, leucine and isoleucine degradation EC:1.2.3.1
reversible: true
reactant: MODEL1310110045#
fast: false
kinetic law: MODEL1310110045#

http://identifiers.org/biomodels.db/MODEL1310110045#_77917422_4292_4a82_a7bb_ba794ef24a0a
is: SBO:0000252
type: Species
initial concentration: NaN
is encoded by: hsa:AI935189
has only substance units: false
constant: false
boundary condition: true
name: _AI935189_1_m
initial amount: NaN

metaM acac m
constant: false
name: acetoacetate
has only substance units: false
is: HMDB00060
is: SBO:0000247
notes: FORMULA: C4H5O3 CHARGE: -1 INCHI: InChI=1S/C4H6O3/c1-3(5)2-4(6)7/h2H2,1H3,(H,6,7)/p-1 HEPATONET_1.0_ABBREVIATION: HC00159 EHMN_ABBREVIATION: C00164
is: CHEBI:13705
type: Species
initial amount: NaN
initial concentration: 1.0
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110045#_bbe0c537_9738_48aa_b6f9_3bdc88880903
initial amount: NaN
is encoded by: hsa:6389
has only substance units: false
is: P31040
boundary condition: true
type: Species
is: SBO:0000252
name: SDHA
constant: false
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110045#_46ae22dc_4c75_459c_85fe_431d1fb625fa
boundary condition: true
initial concentration: NaN
is: O60909
is: SBO:0000252
is encoded by: hsa:8704
constant: false
name: B4GALT2
type: Species
initial amount: NaN
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110045#_3ad7f889_26bd_46ab_8508_e92a79bd7947
has only substance units: false
initial amount: NaN
name: CA14
boundary condition: true
type: Species
is: A8K3J4
initial concentration: NaN
constant: false
is: SBO:0000252
is encoded by: hsa:23632

http://identifiers.org/biomodels.db/MODEL1310110045#_97c4376c_d253_4f53_bb9c_7fde486eee8a
has only substance units: false
is: P61457
is encoded by: hsa:5092
is: SBO:0000252
initial concentration: NaN
boundary condition: true
name: PCBD1
type: Species
initial amount: NaN
constant: false

http://identifiers.org/biomodels.db/MODEL1310110045#_dc046864_6754_47ee_8785_442edf5be93a
is: SBO:0000252
name: ACAT1
has only substance units: false
is: P24752
initial concentration: NaN
constant: false
type: Species
is encoded by: hsa:38
initial amount: NaN
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110045#_d3802623_17aa_40be_a981_10e9ceb1ebeb
is: SBO:0000252
constant: false
type: Species
initial amount: NaN
is: A6NFM2
initial concentration: NaN
name: PYCR1
has only substance units: false
is encoded by: hsa:5831
boundary condition: true

metaR GGT6
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Eicosanoid metabolism EC Number: 2.3.2.2 Confidence Level: 2 AUTHORS: PMID:12729612 NOTES:Converts leukotriene E4 (LTE4) to leukotriene D4 (LTE4). NJ
fast: false
is: SBO:0000176
product: MODEL1310110045#
reactant: MODEL1310110045#
reversible: true
kinetic law: MODEL1310110045#
name: Gamma-glutamyltransferase
is described by: ECO:0000000

metaR r0641
is: SBO:0000176
name: (5-Glutamyl)-peptide:amino-acid 5-glutamyltransferase Arachidonic acid metabolism EC:2.3.2.2
kinetic law: MODEL1310110045#
modifier: MODEL1310110045#
type: Reaction
is described by: ECO:0000000
reactant: MODEL1310110045#
is version of: http://identifiers.org/ec-code/3.1.2.4
fast: false
product: MODEL1310110045#
reversible: true
notes: GENE_ASSOCIATION: (26275.1) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.2.2 Confidence Level: 0 AUTHORS: PMID:1968061 NOTES:

metaM ksi deg26 l
notes: FORMULA: C110H179N7O93S4 CHARGE: -4
has only substance units: false
boundary condition: false
constant: false
is: HMDB00061
is: CHEBI:58343
name: keratan sulfate I, degradation product 26
type: Species
initial amount: NaN
initial concentration: 1.0
is: SBO:0000247

metaM lac L c
is: CHEBI:16651
is: HMDB00190
name: (S)-lactate
type: Species
boundary condition: false
notes: FORMULA: C3H5O3 CHARGE: -1 INCHI: InChI=1S/C3H6O3/c1-2(4)3(5)6/h2,4H,1H3,(H,5,6)/p-1/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00177
constant: false
is: SBO:0000247
has only substance units: false
initial amount: NaN
initial concentration: 1.0

metaM ksi pre12 g
has only substance units: false
initial concentration: 1.0
boundary condition: false
constant: false
notes: FORMULA: C135H218N9O106S3X CHARGE: -4
is: C00130
is: SBO:0000247
is: HMDB00175
type: Species
initial amount: NaN
is: CHEBI:58053
name: keratan sulfate I biosynthesis, precursor 12

metaR r0642
kinetic law: MODEL1310110045#
product: MODEL1310110045#
reactant: MODEL1310110045#
is: SBO:0000176
type: Reaction
name: (S)-Methylmalonate semialdehyde:NAD+ oxidoreductase Valine, leucine and isoleucine degradation EC:1.2.1.3
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 1.2.1.3 Confidence Level: 0 AUTHORS: PMID:10947204,PMID:10989432,PMID:1527093,PMID:16683190,PMID:8120000,PMID:8155713,PMID:8634152,PMID:9787093 NOTES:
is described by: ECO:0000000
reversible: true
fast: false

metaR AG13T6g
fast: false
is version of: http://identifiers.org/ec-code/2.4.1.149
reactant: MODEL1310110045#
reversible: false
name: N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase, Golgi apparatus
product: MODEL1310110045#
is: SBO:0000176
modifier: MODEL1310110045#
notes: GENE_ASSOCIATION: (79369.1) or (374907.1) or (11041.1) or (146712.1) or (374907.2) or (93010.1) or (10331.1) or (10678.1) or (10678.2) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.149 Confidence Level: 4 AUTHORS: PMID:10747980,PMID:11042166,PMID:12061784,PMID:12512857,PMID:15560372,PMID:15620693,PMID:9405606 NOTES:NCD
kinetic law: MODEL1310110045#
is described by: ECO:0000000
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110045#_d8a9f2ab_b980_4704_9b8e_105e0a6e1e12
is encoded by: hsa:443
has only substance units: false
initial concentration: NaN
is: Q6FH48
constant: false
type: Species
boundary condition: true
initial amount: NaN
name: ASPA
is: SBO:0000252

metaR ADSS
modifier: MODEL1310110045#
is version of: http://identifiers.org/ec-code/6.3.4.4
name: adenylosuccinate synthase
type: Reaction
reversible: false
is: SBO:0000176
product: MODEL1310110045#
fast: false
reactant: MODEL1310110045#
notes: GENE_ASSOCIATION: (159.1) or (122622.1) or (122622.2) SUBSYSTEM: Nucleotide interconversion EC Number: 6.3.4.4 Confidence Level: 2 AUTHORS: PMID:1592113 NOTES:r0277
is described by: ECO:0000134
kinetic law: MODEL1310110045#

http://identifiers.org/biomodels.db/MODEL1310110045#_5df1d571_4b82_4300_91d4_cfaa480d7c49
initial amount: NaN
is encoded by: hsa:AW277253
constant: false
type: Species
has only substance units: false
is: SBO:0000252
name: _AW277253_1_c
boundary condition: true
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110045#_b1490417_30d1_4a07_8e0a_b616731a854e
initial concentration: NaN
is: SBO:0000252
name: B3GNT3
is: Q9Y2A9
initial amount: NaN
type: Species
constant: false
is encoded by: hsa:10331
has only substance units: false
boundary condition: true

metaR URIt
reversible: true
modifier: MODEL1310110045#
fast: false
notes: GENE_ASSOCIATION: (3177.1) or (2030.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10722669,PMID:12838422 NOTES:IT
reactant: MODEL1310110045#
is: SBO:0000185
is described by: ECO:0000269
type: Reaction
kinetic law: MODEL1310110045#
name: uridine facilated transport in cytosol
product: MODEL1310110045#

metaM paps g
notes: FORMULA: C10H11N5O13P2S CHARGE: -4 INCHI: InChI=1S/C10H15N5O13P2S/c11-8-5-9(13-2-12-8)15(3-14-5)10-6(16)7(27-29(17,18)19)4(26-10)1-25-30(20,21)28-31(22,23)24/h2-4,6-7,10,16H,1H2,(H,20,21)(H2,11,12,13)(H2,17,18,19)(H,22,23,24)/p-4/t4-,6-,7-,10-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00058 EHMN_ABBREVIATION: C00053
initial amount: NaN
has only substance units: false
constant: false
is: CHEBI:58339
type: Species
is: HMDB01134
name: (2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-4-hydroxy-2-({[(sulfonatooxy)phosphinato]oxy}methyl)oxolan-3-yl phosphate
is: SBO:0000247
boundary condition: false
initial concentration: 1.0

metaR DURIPP
kinetic law: MODEL1310110045#
is version of: http://identifiers.org/ec-code/2.4.2.3
is: SBO:0000176
reversible: true
fast: false
product: MODEL1310110045#
modifier: MODEL1310110045#
is described by: ECO:0000269
name: deoxyuridine phosphorylase
reactant: MODEL1310110045#
type: Reaction
notes: GENE_ASSOCIATION: (4860.1) or (151531.1) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: PMID:11278417,PMID:12849978,PMID:6087295,PMID:9305963 NOTES:JLR
is version of: http://identifiers.org/ec-code/2.4.2.1

metaR NAGA2ly
is version of: http://identifiers.org/ec-code/3.2.1.49
is: SBO:0000176
fast: false
modifier: MODEL1310110045#
notes: GENE_ASSOCIATION: (4668.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.49 Confidence Level: 4 AUTHORS: PMID:2174888,PMID:2551294 NOTES:Alpha-galactosidase B NJ
kinetic law: MODEL1310110045#
type: Reaction
product: MODEL1310110045#
reversible: false
name: N-acetylgalactosaminidase, alpha-
reactant: MODEL1310110045#
is described by: ECO:0000000

metaM tdchola e
is: SBO:0000247
initial amount: NaN
boundary condition: false
notes: FORMULA: C26H45NO6S CHARGE: 0 INCHI: InChI=1S/C26H45NO6S/c1-16(4-7-23(30)27-12-13-34(31,32)33)19-5-6-20-24-21(9-11-26(19,20)3)25(2)10-8-18(28)14-17(25)15-22(24)29/h16-22,24,28-29H,4-15H2,1-3H3,(H,27,30)(H,31,32,33)/p-1/t16-,17+,18-,19-,20+,21+,22-,24+,25+,26-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01471 EHMN_ABBREVIATION: C05465
is: CHEBI:9407
is: HMDB00951
type: Species
name: taurochenodeoxycholate
has only substance units: false
initial concentration: 1.0
constant: false

metaR PSSA1 hs
kinetic law: MODEL1310110045#
type: Reaction
fast: false
is: SBO:0000176
product: MODEL1310110045#
reversible: true
name: Phosphatidylserine synthase homo sapiens
reactant: MODEL1310110045#
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (9791.1) SUBSYSTEM: Glycerophospholipid metabolism EC Number: 2.7.8.8 Confidence Level: 4 AUTHORS: NOTES:phosphatidylcholine as substrate NJ
is version of: http://identifiers.org/ec-code/2.7.8.29
modifier: MODEL1310110045#

metaM lac L e
initial concentration: 1.0
has only substance units: false
is: HMDB00190
constant: false
type: Species
name: (S)-lactate
boundary condition: false
is: SBO:0000247
initial amount: NaN
notes: FORMULA: C3H5O3 CHARGE: -1 INCHI: InChI=1S/C3H6O3/c1-2(4)3(5)6/h2,4H,1H3,(H,5,6)/p-1/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00177
is: CHEBI:16651

http://identifiers.org/biomodels.db/MODEL1310110045#_8ea799b4_259c_4124_abde_5843f8220605
is encoded by: hsa:51727
initial amount: NaN
has only substance units: false
is: SBO:0000252
name: CMPK1
constant: false
is: B2R6S5
type: Species
boundary condition: true
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110045#_731db5fb_419d_43eb_b774_8e04931f0233
is encoded by: hsa:115286
name: SLC25A26
initial amount: NaN
type: Species
constant: false
is: SBO:0000252
initial concentration: NaN
has only substance units: false
boundary condition: true

metaM adprib e
is: CHEBI:57967
boundary condition: false
is: SBO:0000247
has only substance units: false
is: HMDB01178
name: D-ribofuranos-5-yl-ADP(2-)
notes: FORMULA: C15H21N5O14P2 CHARGE: -2 INCHI: InChI=1S/C15H23N5O14P2/c16-12-7-13(18-3-17-12)20(4-19-7)14-10(23)8(21)5(32-14)1-30-35(26,27)34-36(28,29)31-2-6-9(22)11(24)15(25)33-6/h3-6,8-11,14-15,21-25H,1-2H2,(H,26,27)(H,28,29)(H2,16,17,18)/p-2/t5-,6-,8-,9-,10-,11-,14-,15?/m1/s1 EHMN_ABBREVIATION: C00301
initial amount: NaN
type: Species
constant: false
initial concentration: 1.0

metaR EX pheacgln LPAREN e RPAREN
kinetic law: MODEL1310110045#
reactant: MODEL1310110045#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: alpha-N-Phenylacetyl-L-glutamine exchange
type: Reaction

metaM dpcoa e
type: Species
is: SBO:0000247
is: CHEBI:57328
name: Dephospho-CoA
is: C00882
is: HMDB01373
boundary condition: false
initial amount: NaN
has only substance units: false
initial concentration: 1.0
constant: false
notes: FORMULA: C21H33N7O13P2S CHARGE: -2

metaR PRASCS
is: SBO:0000176
is described by: ECO:0000269
product: MODEL1310110045#
notes: GENE_ASSOCIATION: (10606.1) SUBSYSTEM: Purine synthesis EC Number: Confidence Level: 4 AUTHORS: NOTES:
is version of: http://identifiers.org/ec-code/6.3.2.6
kinetic law: MODEL1310110045#
type: Reaction
reversible: true
fast: false
reactant: MODEL1310110045#
modifier: MODEL1310110045#
name: phosphoribosylaminoimidazolesuccinocarboxamide synthase

metaR D3AIBTm
fast: false
name: D-3-Amino-isobutanoate:pyruvate aminotransferase, mitochondrial
is: SBO:0000176
reactant: MODEL1310110045#
type: Reaction
product: MODEL1310110045#
reversible: true
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Pyrimidine catabolism EC Number: 2.6.1.40 Confidence Level: 4 AUTHORS: PMID:5773299 NOTES:MM
kinetic law: MODEL1310110045#

metaR M16N6Tg
fast: false
is described by: ECO:0000000
name: alpha-1,6-mannosyl-glycoprotein 6-beta-N-acetylglucosaminyltransferase
is version of: http://identifiers.org/ec-code/2.4.1.155
reversible: false
product: MODEL1310110045#
kinetic law: MODEL1310110045#
notes: GENE_ASSOCIATION: (4249.1) SUBSYSTEM: N-glycan synthesis EC Number: 2.4.1.155 Confidence Level: 0 AUTHORS: NOTES:NCD
modifier: MODEL1310110045#
is: SBO:0000176
reactant: MODEL1310110045#
type: Reaction

metaM 3docopencoa m
is: HMDB06294
is: SBO:0000247
notes: FORMULA: C43H64N7O17P3S CHARGE: -4
initial concentration: 1.0
has only substance units: false
initial amount: NaN
name: 3,7,10,13,16-docosapentenoylcoa
constant: false
boundary condition: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110045#_84822f9d_18ab_45dd_b5e9_ecece66cec09
is: Q14117
is: SBO:0000252
type: Species
name: DPYS
initial amount: NaN
has only substance units: false
is encoded by: hsa:1807
boundary condition: true
initial concentration: NaN
constant: false

metaR r0321
reversible: false
modifier: MODEL1310110045#
is described by: ECO:0000000
fast: false
kinetic law: MODEL1310110045#
type: Reaction
is version of: http://identifiers.org/ec-code/6.3.5.2
product: MODEL1310110045#
notes: GENE_ASSOCIATION: (AA664770.1) or (AI684467.1) or (8833.1) SUBSYSTEM: Cholesterol metabolism EC Number: 6.2.1.16 Confidence Level: 0 AUTHORS: PMID:4073493 NOTES:
name: Acetoacetate:CoA ligase (AMP-forming) Butanoate metabolism EC:6.2.1.16
reactant: MODEL1310110045#
is: SBO:0000176

metaM adn m
is: HMDB00050
is: CHEBI:16335
boundary condition: false
name: adenosine
initial concentration: 1.0
type: Species
is: SBO:0000247
has only substance units: false
notes: FORMULA: C10H13N5O4 CHARGE: 0 INCHI: InChI=1S/C10H13N5O4/c11-8-5-9(13-2-12-8)15(3-14-5)10-7(18)6(17)4(1-16)19-10/h2-4,6-7,10,16-18H,1H2,(H2,11,12,13)/t4-,6-,7-,10-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00196 EHMN_ABBREVIATION: C00212
initial amount: NaN
constant: false

metaM ksi deg9 l
notes: FORMULA: C188H301N13O166S10 CHARGE: -10
is: SBO:0000247
name: keratan sulfate I, degradation product 9
is: HMDB00143
initial concentration: 1.0
boundary condition: false
initial amount: NaN
type: Species
constant: false
has only substance units: false
is: CHEBI:12936

metaR URIDK2m
notes: GENE_ASSOCIATION: SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 1 AUTHORS: PMID:17999954 NOTES:IT
reversible: true
type: Reaction
is described by: ECO:0000134
product: MODEL1310110045#
kinetic law: MODEL1310110045#
is: SBO:0000176
name: uridylate kinase (dUMP), mitochondrial
reactant: MODEL1310110045#
fast: false

metaM HC00591 c
boundary condition: false
initial amount: NaN
name: 2-oxoglutaramate
is: CHEBI:16769
type: Species
initial concentration: 1.0
is: SBO:0000247
notes: FORMULA: C5H6NO4 CHARGE: -1 INCHI: InChI=1S/C5H7NO4/c6-4(8)2-1-3(7)5(9)10/h1-2H2,(H2,6,8)(H,9,10)/p-1 EHMN_ABBREVIATION: C00940
constant: false
has only substance units: false

metaR r2330
fast: false
kinetic law: MODEL1310110045#
type: Reaction
reversible: true
product: MODEL1310110045#
reactant: MODEL1310110045#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
is described by: ECO:0000000
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110045#_f2247bc3_fe24_4019_a69b_c076478f2808
is: Q53G02
is: SBO:0000252
initial concentration: NaN
is encoded by: hsa:1603
type: Species
boundary condition: true
has only substance units: false
name: DAD1
initial amount: NaN
constant: false

metaR EX HC02202 LPAREN e RPAREN
kinetic law: MODEL1310110045#
reactant: MODEL1310110045#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: prostaglandin A1(1-) exchange
type: Reaction

metaR S23T3g
is: SBO:0000176
fast: false
reversible: false
name: beta-galactoside alpha-2,3-sialyltransferase (complex N-glycan)
product: MODEL1310110045#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (6487.4) or (6487.9) or (6487.11) or (6487.6) or (6487.7) or (6487.10) or (6487.5) or (6487.1) or (6487.2) or (6487.8) or (6487.3) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.99.6 Confidence Level: 4 AUTHORS: PMID:8333853 NOTES:NCD
type: Reaction
modifier: MODEL1310110045#
is version of: http://identifiers.org/ec-code/2.4.99.6
kinetic law: MODEL1310110045#
reactant: MODEL1310110045#

metaM tdchola c
is: SBO:0000247
boundary condition: false
constant: false
notes: FORMULA: C26H45NO6S CHARGE: 0 INCHI: InChI=1S/C26H45NO6S/c1-16(4-7-23(30)27-12-13-34(31,32)33)19-5-6-20-24-21(9-11-26(19,20)3)25(2)10-8-18(28)14-17(25)15-22(24)29/h16-22,24,28-29H,4-15H2,1-3H3,(H,27,30)(H,31,32,33)/p-1/t16-,17+,18-,19-,20+,21+,22-,24+,25+,26-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01471 EHMN_ABBREVIATION: C05465
initial amount: NaN
is: HMDB00951
name: taurochenodeoxycholate
is: CHEBI:9407
initial concentration: 1.0
has only substance units: false
type: Species

metaR CORE2GTg
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/2.4.1.102
notes: GENE_ASSOCIATION: (9245.1) or (2650.1) or (51301.1) SUBSYSTEM: O-glycan synthesis EC Number: 2.4.1.102 Confidence Level: 0 AUTHORS: PMID:10753916,PMID:9915862 NOTES:NCD
kinetic law: MODEL1310110045#
name: Core 2 acetylglucosaminyltransferase, Golgi apparatus
reactant: MODEL1310110045#
type: Reaction
is: SBO:0000176
reversible: false
modifier: MODEL1310110045#
product: MODEL1310110045#
fast: false

metaM cytd m
initial amount: NaN
is: HMDB00089
name: cytidine
boundary condition: false
notes: FORMULA: C9H13N3O5 CHARGE: 0 INCHI: InChI=1S/C9H13N3O5/c10-5-1-2-12(9(16)11-5)8-7(15)6(14)4(3-13)17-8/h1-2,4,6-8,13-15H,3H2,(H2,10,11,16)/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00381 EHMN_ABBREVIATION: C00475
is: CHEBI:17562
initial concentration: 1.0
constant: false
type: Species
has only substance units: false
is: SBO:0000247

metaR EX dhdascb LPAREN e RPAREN
kinetic law: MODEL1310110045#
reactant: MODEL1310110045#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for dehydroascorbide(1-)
type: Reaction

metaR r2331
product: MODEL1310110045#
reactant: MODEL1310110045#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
is: SBO:0000185
fast: false
kinetic law: MODEL1310110045#
reversible: true
is described by: ECO:0000000

metaM dpcoa c
has only substance units: false
is: SBO:0000247
name: Dephospho-CoA
is: C00882
boundary condition: false
initial concentration: 1.0
constant: false
is: HMDB01373
initial amount: NaN
type: Species
notes: FORMULA: C21H33N7O13P2S CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00575 EHMN_ABBREVIATION: C00882
is: CHEBI:57328

metaM anth e
initial concentration: 1.0
name: anthranilate
is: HMDB01123
is: SBO:0000247
type: Species
notes: FORMULA: C7H6NO2 CHARGE: -1 INCHI: InChI=1S/C7H7NO2/c8-6-4-2-1-3-5(6)7(9)10/h1-4H,8H2,(H,9,10)/p-1
initial amount: NaN
is: CHEBI:16567
boundary condition: false
has only substance units: false
constant: false

metaM acac x
is: CHEBI:13705
initial concentration: 1.0
type: Species
name: acetoacetate
constant: false
is: SBO:0000247
has only substance units: false
boundary condition: false
initial amount: NaN
is: HMDB00060
notes: FORMULA: C4H5O3 CHARGE: -1 INCHI: InChI=1S/C4H6O3/c1-3(5)2-4(6)7/h2H2,1H3,(H,6,7)/p-1 HEPATONET_1.0_ABBREVIATION: HC00159 EHMN_ABBREVIATION: C00164

metaR PGI
kinetic law: MODEL1310110045#
notes: GENE_ASSOCIATION: (2821.1) SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: 5.3.1.9 Confidence Level: 0 AUTHORS: PMID:19064002,PMID:2241164,PMID:8530082 NOTES:
is described by: ECO:0000134
reactant: MODEL1310110045#
is version of: http://identifiers.org/ec-code/5.3.1.9
fast: false
modifier: MODEL1310110045#
type: Reaction
name: glucose-6-phosphate isomerase
is: SBO:0000176
reversible: true
product: MODEL1310110045#

metaR THFtm
is: SBO:0000185
fast: false
kinetic law: MODEL1310110045#
reactant: MODEL1310110045#
type: Reaction
reversible: true
product: MODEL1310110045#
is described by: ECO:0000000
name: 5,6,7,8-Tetrahydrofolate transport, diffusion, mitochondrial
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: PMID:11375437 NOTES:NCD

http://identifiers.org/biomodels.db/MODEL1310110045#_d729fced_79e9_4d78_9fdc_a163668b015f
is encoded by: hsa:1716
constant: false
initial concentration: NaN
boundary condition: true
has only substance units: false
is: SBO:0000252
name: DGUOK
type: Species
initial amount: NaN
is: E5KSL6

metaR HEXDICOAACBPx
kinetic law: MODEL1310110045#
product: MODEL1310110045#
reactant: MODEL1310110045#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of hexadecanedioyl coa
type: Reaction

metaR r0437
reactant: MODEL1310110045#
fast: false
modifier: MODEL1310110045#
kinetic law: MODEL1310110045#
name: Palmitoyl-CoA:L-carnitine O-palmitoyltransferase Fatty acid metabolism EC:2.3.1.21
notes: GENE_ASSOCIATION: (AI469183.1) or (226.1) or (229.1) or (230.1) or (BC005314.1) or (BF195998.1) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.21 Confidence Level: 0 AUTHORS: PMID:1735445,PMID:1988962,PMID:2355017,PMID:6361812,PMID:7892212 NOTES:
is version of: http://identifiers.org/ec-code/4.1.2.13
product: MODEL1310110045#
reversible: true
is: SBO:0000176
type: Reaction
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110045#_9874e6aa_4fea_4c86_91ea_bf3adf555548
constant: false
initial concentration: NaN
initial amount: NaN
is: SBO:0000252
is encoded by: hsa:1854
is: P33316
has only substance units: false
boundary condition: true
name: DUT
type: Species

metaR FAOXC16DCC14DCx
kinetic law: MODEL1310110045#
product: MODEL1310110045#
reactant: MODEL1310110045#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C16DC-->C14DC)x
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110045#_719e3c70_39c4_4e0f_bc86_40194f43add6
name: APRT
constant: false
boundary condition: true
is encoded by: hsa:353
type: Species
is: SBO:0000252
is: P07741
has only substance units: false
initial concentration: NaN
initial amount: NaN

metaR XYLt
fast: false
modifier: MODEL1310110045#
reactant: MODEL1310110045#
name: D-xylose reversible transport
type: Reaction
notes: GENE_ASSOCIATION: (6515.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10421229,PMID:12750891,PMID:3170580,PMID:8504756,PMID:9230074 NOTES:NCD
kinetic law: MODEL1310110045#
reversible: true
product: MODEL1310110045#
is described by: ECO:0000269
is: SBO:0000185

metaR EX ascb L LPAREN e RPAREN
kinetic law: MODEL1310110045#
reactant: MODEL1310110045#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: L-Ascorbate exchange
type: Reaction

metaM paps c
name: (2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-4-hydroxy-2-({[(sulfonatooxy)phosphinato]oxy}methyl)oxolan-3-yl phosphate
constant: false
type: Species
has only substance units: false
is: SBO:0000247
is: HMDB01134
is: CHEBI:58339
initial amount: NaN
initial concentration: 1.0
notes: FORMULA: C10H11N5O13P2S CHARGE: -4 INCHI: InChI=1S/C10H15N5O13P2S/c11-8-5-9(13-2-12-8)15(3-14-5)10-6(16)7(27-29(17,18)19)4(26-10)1-25-30(20,21)28-31(22,23)24/h2-4,6-7,10,16H,1H2,(H,20,21)(H2,11,12,13)(H2,17,18,19)(H,22,23,24)/p-4/t4-,6-,7-,10-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00058 EHMN_ABBREVIATION: C00053
boundary condition: false

metaR CBASPte
fast: false
is described by: ECO:0000134
reactant: MODEL1310110045#
reversible: true
name: Transport of N-carbamoyl-L-aspartate
kinetic law: MODEL1310110045#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
type: Reaction
is: SBO:0000185
product: MODEL1310110045#

metaR EX xolest2 hs LPAREN e RPAREN
kinetic law: MODEL1310110045#
reactant: MODEL1310110045#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: cholesterol ester (from FULLR2) exchange
type: Reaction

metaM lnlnca c
boundary condition: false
initial amount: NaN
initial concentration: 1.0
is: CHEBI:32387
has only substance units: false
name: alpha-linolenate
constant: false
is: SBO:0000247
type: Species
notes: FORMULA: C18H29O2 CHARGE: -1 INCHI: InChI=1S/C18H30O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20/h3-4,6-7,9-10H,2,5,8,11-17H2,1H3,(H,19,20)/p-1/b4-3-,7-6-,10-9-
is: HMDB01388

metaR RTOTAL3FATPc
kinetic law: MODEL1310110045#
product: MODEL1310110045#
reactant: MODEL1310110045#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: uptake of Rtotal3 by enterocytes
type: Reaction

metaR r0539
notes: GENE_ASSOCIATION: (3156.1) SUBSYSTEM: Taurine and hypotaurine metabolism EC Number: 1.13.11.19 Confidence Level: 0 AUTHORS: PMID:17153586,PMID:17581819,PMID:3657558 NOTES:
is: SBO:0000176
type: Reaction
is version of: http://identifiers.org/ec-code/1.1.1.34
kinetic law: MODEL1310110045#
is described by: ECO:0000000
product: MODEL1310110045#
fast: false
modifier: MODEL1310110045#
name: Cysteamine:oxygen oxidoreductase Taurine and hypotaurine metabolism EC:1.13.11.19
reactant: MODEL1310110045#
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110045#_81118cbf_24b9_4021_8550_300f352e2445
initial amount: NaN
name: EHHADH
is: Q9NY65
is: SBO:0000252
boundary condition: true
initial concentration: NaN
type: Species
has only substance units: false
constant: false
is encoded by: hsa:1962

http://identifiers.org/biomodels.db/MODEL1310110045#_cee64f03_5c59_4af9_b17e_0516b8577045
constant: false
initial concentration: NaN
is: SBO:0000297
boundary condition: true
has part: Q86U05
initial amount: NaN
type: Species
is encoded by: hsa:23428
has only substance units: false
name: SLC7A8:SLC3A2

http://identifiers.org/biomodels.db/MODEL1310110045#_f8897ba0_a05b_40a9_b4ea_d09eb877ce7a
is: Q5JWV8
constant: false
initial concentration: NaN
type: Species
is encoded by: hsa:2182
boundary condition: true
initial amount: NaN
is: SBO:0000252
has only substance units: false
name: ACSL4

http://identifiers.org/biomodels.db/MODEL1310110045#_c07d8e17_55f6_437b_b253_871010477f91
has only substance units: false
initial concentration: NaN
type: Species
is encoded by: hsa:8395
is: O14986
constant: false
boundary condition: true
is: SBO:0000252
initial amount: NaN
name: PIP5K1B

metaM anth c
type: Species
is: SBO:0000247
has only substance units: false
name: anthranilate
is: CHEBI:16567
boundary condition: false
notes: FORMULA: C7H6NO2 CHARGE: -1 INCHI: InChI=1S/C7H7NO2/c8-6-4-2-1-3-5(6)7(9)10/h1-4H,8H2,(H,9,10)/p-1 HEPATONET_1.0_ABBREVIATION: HC00107 EHMN_ABBREVIATION: C00108
initial amount: NaN
constant: false
is: HMDB01123
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110045#_115c71f4_3bfb_49e7_a48c_508f04cb7391
is: SBO:0000252
type: Species
constant: false
boundary condition: true
is encoded by: hsa:642502
name: _642502_1_c
has only substance units: false
initial concentration: NaN
initial amount: NaN

metaR PRO Dtde
fast: false
product: MODEL1310110045#
reactant: MODEL1310110045#
kinetic law: MODEL1310110045#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 1 AUTHORS: added during gap-filling. Diffusion into the blood is assumed. NOTES:added during gap-filling. Diffusion into the blood is assumed.
name: D-proline transport, extracellular
is: SBO:0000185
is described by: ECO:0000134
type: Reaction
reversible: true

metaM n5m2masn g
constant: false
is: HMDB00224
name: ((N-acetyl-D-glucosaminyl)5-(alpha-D-mannosyl)2-beta-D-mannosyl-diacetylchitobiosyl)-L-asparagine (protein)
boundary condition: false
is: SBO:0000247
initial concentration: 1.0
type: Species
has only substance units: false
notes: FORMULA: C74H122N7O50X CHARGE: 0
initial amount: NaN
is: CHEBI:58190

metaM h2o2 m
is: C00027
is: CHEBI:16240
notes: FORMULA: H2O2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00036 EHMN_ABBREVIATION: C00027
name: Hydrogen peroxide
initial amount: NaN
is: HMDB03125
type: Species
boundary condition: false
has only substance units: false
is: SBO:0000247
initial concentration: 1.0
constant: false

metaR r0860
reversible: true
notes: GENE_ASSOCIATION: (8879.1) SUBSYSTEM: Purine catabolism EC Number: Confidence Level: 0 AUTHORS: PMID:1459,PMID:14598172,PMID:18406340,PMID:8132483 NOTES:
product: MODEL1310110045#
name: Utilized transport
type: Reaction
kinetic law: MODEL1310110045#
is version of: http://identifiers.org/ec-code/4.1.2.27
modifier: MODEL1310110045#
fast: false
is: SBO:0000185
reactant: MODEL1310110045#
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110045#_22172839_d707_4401_a22d_d720cea280d2
constant: false
has only substance units: false
is encoded by: hsa:AA203143
initial amount: NaN
boundary condition: true
type: Species
name: _AA203143_1_c
is: SBO:0000252
initial concentration: NaN

metaR RTOTAL2t
is: SBO:0000185
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:14598172 NOTES:
reversible: true
kinetic law: MODEL1310110045#
name: RTOTAL2 transport
product: MODEL1310110045#
is described by: ECO:0000000
reactant: MODEL1310110045#
fast: false

http://identifiers.org/biomodels.db/MODEL1310110045#_b3cac885_a904_4ad3_85a2_beb14b6599cf
type: Species
has only substance units: false
initial concentration: NaN
is encoded by: hsa:55163
boundary condition: true
is: SBO:0000252
constant: false
is: Q9NVS9
initial amount: NaN
name: PNPO

http://identifiers.org/biomodels.db/MODEL1310110045#_29da5933_64eb_40a4_b046_f898ec0cd93a
initial amount: NaN
constant: false
initial concentration: NaN
type: Species
is encoded by: hsa:AI378339
name: _AI378339_1_m
has only substance units: false
boundary condition: true
is: SBO:0000252

metaR AKR1C41
is version of: http://identifiers.org/ec-code/1.1.1.225
is described by: ECO:0000269
reactant: MODEL1310110045#
fast: false
reversible: false
modifier: MODEL1310110045#
notes: GENE_ASSOCIATION: (1109.1) SUBSYSTEM: Bile acid synthesis EC Number: 1.1.1.50 Confidence Level: 4 AUTHORS: NOTES:NJ
type: Reaction
is: SBO:0000176
kinetic law: MODEL1310110045#
product: MODEL1310110045#
name: aldo-keto reductase family 1, member C4 (chlordecone reductase; 3-alpha hydroxysteroid dehydrogenase, type I; dihydrodiol dehydrogenase 4)

W3 CDTF: Fri Aug 31 04:08:02 BST 2012

metaM 1p3h5c m
name: L-1-Pyrroline-3-hydroxy-5-carboxylate
initial amount: NaN
constant: false
initial concentration: 1.0
type: Species
boundary condition: false
is: SBO:0000247
has only substance units: false
notes: FORMULA: C5H6NO3 CHARGE: -1 INCHI: InChI=1S/C5H7NO3/c7-3-1-4(5(8)9)6-2-3/h2-4,7H,1H2,(H,8,9)/t3-,4+/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01261 EHMN_ABBREVIATION: C04281
is: CHEBI:6151
is: HMDB01369

metaR r0755
is: SBO:0000176
reversible: true
type: Reaction
product: MODEL1310110045#
modifier: MODEL1310110045#
name: 3-Methoxy-4-hydroxyphenylacetaldehyde:NADP+ oxidoreductase Tyrosine metabolism EC:1.2.1.5
fast: false
reactant: MODEL1310110045#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (27034.1) or (28976.1) or (37.1) SUBSYSTEM: Unassigned EC Number: 1.2.1.5 Confidence Level: 0 AUTHORS: PMID:1898068 NOTES:
kinetic law: MODEL1310110045#

http://identifiers.org/biomodels.db/MODEL1310110045#_4eecab5c_4b3c_4761_8a86_7476604558c6
has only substance units: false
type: Species
initial amount: NaN
is: SBO:0000252
is encoded by: hsa:5294
is: P48736
constant: false
initial concentration: NaN
boundary condition: true
name: PIK3CG

http://identifiers.org/biomodels.db/MODEL1310110045#_daa60d68_57f9_4c66_8be8_4e0fc965fc39
has only substance units: false
boundary condition: true
constant: false
type: Species
is: B3KQ63
initial concentration: NaN
is encoded by: hsa:3242
name: HPD
initial amount: NaN
is: SBO:0000252

metaR NACHEXA13ly
reactant: MODEL1310110045#
name: beta-N-acetylhexosaminidase A, lysosomal
kinetic law: MODEL1310110045#
is version of: http://identifiers.org/ec-code/3.2.1.52
modifier: MODEL1310110045#
type: Reaction
is described by: ECO:0000000
reversible: false
notes: GENE_ASSOCIATION: (3073.1) or (3073.1 and 3074.1) SUBSYSTEM: Keratan sulfate degradation EC Number: Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12706724,PMID:8993162 NOTES:Note that this reaction is specific to beta-N-acetylhexosaminidase A and cannot be catalyzed by beta-N-acetylhexosaminidase B (or presumably beta-N-acetylhexosaminidase S). This is also a lumped reaction, representing the cleavage of GalNAc4S or GalNAc6S and N-acetylgalactosamine 4-sulfatase or 6-sulfatase. NCD
fast: false
is: SBO:0000176
product: MODEL1310110045#

metaR N2M2NMASNtly
fast: false
reactant: MODEL1310110045#
name: n2m2nmasn transport, extracellular to lysosome
is described by: ECO:0000000
type: Reaction
is: SBO:0000185
reversible: false
kinetic law: MODEL1310110045#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD
product: MODEL1310110045#

W3 CDTF: Fri Aug 31 04:08:02 BST 2012

metaR EX ahcys LPAREN e RPAREN
kinetic law: MODEL1310110045#
reactant: MODEL1310110045#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: Exchange of S-adenosyl-L-homocysteine
type: Reaction

metaR r0754
fast: false
reactant: MODEL1310110045#
is: SBO:0000176
reversible: true
type: Reaction
name: 3-Methoxy-4-hydroxyphenylacetaldehyde:NAD+ oxidoreductase Tyrosine metabolism EC:1.2.1.5
modifier: MODEL1310110045#
kinetic law: MODEL1310110045#
is version of: http://identifiers.org/ec-code/2.3.1.85
product: MODEL1310110045#
notes: GENE_ASSOCIATION: (2194.1) SUBSYSTEM: Unassigned EC Number: 1.2.1.5 Confidence Level: 0 AUTHORS: PMID:17379813,PMID:18621017 NOTES:
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110045#_b137f140_e223_4018_b95e_d547ae752b57
has only substance units: false
boundary condition: true
constant: false
is: SBO:0000252
is encoded by: hsa:2687
initial amount: NaN
type: Species
name: GGT5
initial concentration: NaN
is: P36269

metaR MM6B2g
name: mannosyl-oligosaccharide 1,2-alpha-mannosidase, Golgi apparatus
is: SBO:0000176
notes: GENE_ASSOCIATION: (4121.1) or (57134.1) or (10905.1) SUBSYSTEM: N-glycan synthesis EC Number: 3.2.1.113 Confidence Level: 0 AUTHORS: PMID:10915796,PMID:9592125 NOTES:NCD
product: MODEL1310110045#
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/3.2.1.113
modifier: MODEL1310110045#
kinetic law: MODEL1310110045#
reversible: false
fast: false
reactant: MODEL1310110045#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110045#_9ffa6a1d_099e_4748_9308_7a18f84eed37
constant: false
boundary condition: true
initial amount: NaN
is encoded by: hsa:64499
name: TPSB2
type: Species
has only substance units: false
initial concentration: NaN
is: P20231
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110045#_5cb3efe2_80f0_45ab_920a_b2f149eacad2
name: ADHFE1
is: SBO:0000252
initial concentration: NaN
is: Q8IWW8
is encoded by: hsa:137872
type: Species
constant: false
boundary condition: true
has only substance units: false
initial amount: NaN

W3 CDTF: Fri Aug 31 04:08:02 BST 2012

metaR MG1er
is: SBO:0000176
fast: false
notes: GENE_ASSOCIATION: (7841.1) SUBSYSTEM: N-glycan synthesis EC Number: 3.2.1.106 Confidence Level: 0 AUTHORS: NOTES:NCD
name: mannosyl-oligosaccharide glucosidase, endoplasmic reticulum
type: Reaction
product: MODEL1310110045#
is version of: http://identifiers.org/ec-code/3.2.1.106
kinetic law: MODEL1310110045#
is described by: ECO:0000000
reactant: MODEL1310110045#
modifier: MODEL1310110045#
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110045#_3ff6265c_5140_4c80_a33b_a30fcf4546cf
is: SBO:0000252
constant: false
type: Species
initial concentration: NaN
name: NDUFB6
initial amount: NaN
is: O95139
is encoded by: hsa:4712
boundary condition: true
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110045#_989cb79b_0280_43a5_9138_2775c30f6286
boundary condition: true
is: SBO:0000252
name: GMPS
initial amount: NaN
is: P49915
is encoded by: hsa:8833
initial concentration: NaN
constant: false
type: Species
has only substance units: false

metaR r0753
reversible: true
product: MODEL1310110045#
modifier: MODEL1310110045#
is: SBO:0000176
type: Reaction
name: 3,4-Dihydroxymandelaldehyde:NADP+ oxidoreductase Tyrosine metabolism EC:1.2.1.5
notes: GENE_ASSOCIATION: (2194.1) SUBSYSTEM: Unassigned EC Number: 1.2.1.5 Confidence Level: 0 AUTHORS: PMID:11790142,PMID:12604221 NOTES:
fast: false
reactant: MODEL1310110045#
kinetic law: MODEL1310110045#
is version of: http://identifiers.org/ec-code/2.3.1.85
is described by: ECO:0000000

metaM lpam m
type: Species
initial amount: NaN
initial concentration: 1.0
is: CHEBI:17460
name: lipoamide
notes: FORMULA: C8H15NOS2 CHARGE: 0 INCHI: InChI=1S/C8H15NOS2/c9-8(10)4-2-1-3-7-5-6-11-12-7/h7H,1-6H2,(H2,9,10) HEPATONET_1.0_ABBREVIATION: HC00225 EHMN_ABBREVIATION: C00248
boundary condition: false
is: HMDB00962
has only substance units: false
constant: false
is: SBO:0000247

metaR UAGDP
is described by: ECO:0000269
name: UDP-N-acetylglucosamine diphosphorylase
is version of: http://identifiers.org/ec-code/2.7.7.23
notes: GENE_ASSOCIATION: (6675.1) or (91373.1) SUBSYSTEM: Aminosugar metabolism EC Number: 2.7.7.23 Confidence Level: 4 AUTHORS: PMID:9603950 NOTES:
modifier: MODEL1310110045#
product: MODEL1310110045#
kinetic law: MODEL1310110045#
reactant: MODEL1310110045#
type: Reaction
fast: false
is: SBO:0000176
reversible: false

metaM fadh2 m
notes: FORMULA: C27H33N9O15P2 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00770 EHMN_ABBREVIATION: C01352
name: Flavin adenine dinucleotide reduced
is: C01352
constant: false
has only substance units: false
is: CHEBI:58307
type: Species
is: HMDB01197
is: SBO:0000247
initial concentration: 1.0
boundary condition: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110045#_148fb3a8_1a48_4992_a4ee_8052db03eea8
type: Species
is: SBO:0000252
name: COASY
is encoded by: hsa:80347
initial concentration: NaN
has only substance units: false
initial amount: NaN
is: Q13057
boundary condition: true
constant: false

metaR AKR1C42
reversible: false
notes: GENE_ASSOCIATION: (1109.1) SUBSYSTEM: Bile acid synthesis EC Number: 1.1.1.50 Confidence Level: 4 AUTHORS: NOTES:NJ
type: Reaction
is version of: http://identifiers.org/ec-code/1.1.1.225
is: SBO:0000176
kinetic law: MODEL1310110045#
is described by: ECO:0000269
modifier: MODEL1310110045#
reactant: MODEL1310110045#
name: aldo-keto reductase family 1, member C4 (chlordecone reductase; 3-alpha hydroxysteroid dehydrogenase, type I; dihydrodiol dehydrogenase 4)
product: MODEL1310110045#
fast: false

W3 CDTF: Fri Aug 31 04:08:02 BST 2012

http://identifiers.org/biomodels.db/MODEL1310110045#_cc9a2b06_0209_44b1_809e_dfaaa67a73c4
has only substance units: false
boundary condition: true
initial concentration: NaN
initial amount: NaN
is: P38571
is encoded by: hsa:3988
is: SBO:0000252
type: Species
name: LIPA
constant: false

metaR r0752
is described by: ECO:0000000
fast: false
reversible: true
modifier: MODEL1310110045#
reactant: MODEL1310110045#
kinetic law: MODEL1310110045#
is: SBO:0000176
name: 3,4-Dihydroxymandelaldehyde:NAD+ oxidoreductase Tyrosine metabolism EC:1.2.1.5
type: Reaction
is version of: http://identifiers.org/ec-code/2.3.1.16
product: MODEL1310110045#
notes: GENE_ASSOCIATION: (30.1) or (10449.1) or (3032.1) or (4645.1) SUBSYSTEM: Unassigned EC Number: 1.2.1.5 Confidence Level: 0 AUTHORS: PMID:10424772,PMID:11958479,PMID:3466164 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110045#_f362191b_0752_4f2e_bf5a_d8d2087ab5cc
is encoded by: hsa:AI601100
initial amount: NaN
type: Species
boundary condition: true
name: _AI601100_1_m
constant: false
is: SBO:0000252
has only substance units: false
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110045#_e9cf8cc4_953c_46cd_84de_4f6677333888
is: Q9NTN3
boundary condition: true
is encoded by: hsa:23169
initial concentration: NaN
name: SLC35D1
initial amount: NaN
constant: false
type: Species
has only substance units: false
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110045#_e3e91446_773f_4f4d_b085_0ad0e5d51fdc
constant: false
is encoded by: hsa:39
name: ACAT2
initial amount: NaN
is: Q9BWD1
is: SBO:0000252
has only substance units: false
boundary condition: true
type: Species
initial concentration: NaN

metaR ITCOAL1m
is: SBO:0000176
product: MODEL1310110045#
is described by: ECO:0000304
modifier: MODEL1310110045#
kinetic law: MODEL1310110045#
reactant: MODEL1310110045#
type: Reaction
reversible: true
fast: false
is version of: http://identifiers.org/ec-code/6.2.1.4
name: Itaconate--CoA ligase (GDP-forming), mitochondrial
notes: GENE_ASSOCIATION: (8802.1 and 8801.1) SUBSYSTEM: C5-branched dibasic acid metabolism EC Number: 6.2.1.4 Confidence Level: 2 AUTHORS: PMID:13783048 NOTES:NCD

http://identifiers.org/biomodels.db/MODEL1310110045#_724bab4c_742c_4be1_b6ac_87b6a3219390
is: O76062
initial concentration: NaN
initial amount: NaN
constant: false
name: TM7SF2
has only substance units: false
type: Species
is: SBO:0000252
boundary condition: true
is encoded by: hsa:7108

http://identifiers.org/biomodels.db/MODEL1310110045#_bceba5e6_36d2_473f_82e2_589e63d82a67
name: ME2
is: P23368
is: SBO:0000252
constant: false
has only substance units: false
is encoded by: hsa:4200
type: Species
initial amount: NaN
initial concentration: NaN
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110045#_ee418902_7dba_4271_b9bc_426f0d0427ab
is: P35754
constant: false
type: Species
has only substance units: false
is: SBO:0000252
initial concentration: NaN
initial amount: NaN
name: GLRX
is encoded by: hsa:2745
boundary condition: true

metaM dhap x
initial concentration: 1.0
is: SBO:0000247
boundary condition: false
type: Species
initial amount: NaN
is: HMDB01473
has only substance units: false
is: CHEBI:57642
is: http://identifiers.org/pubchem.compound/3411
name: Dihydroxyacetone phosphate
constant: false
is: C00111

metaR r2113
type: Reaction
product: MODEL1310110045#
is described by: ECO:0000000
reversible: true
fast: false
reactant: MODEL1310110045#
is: SBO:0000185
modifier: MODEL1310110045#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
kinetic law: MODEL1310110045#

metaR AHEXASE2ly
kinetic law: MODEL1310110045#
product: MODEL1310110045#
is: SBO:0000176
fast: false
modifier: MODEL1310110045#
name: beta-N-acetylhexosaminidase, lysosomal
type: Reaction
reactant: MODEL1310110045#
reversible: false
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (3074.1) or (3073.1) or (3073.1 and 3074.1) SUBSYSTEM: N-glycan degradation EC Number: 3.2.1.52 Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12706724 NOTES:NCD
is version of: http://identifiers.org/ec-code/3.2.1.52

http://identifiers.org/biomodels.db/MODEL1310110045#_57008969_ac2d_46a4_aa46_a6b12227e51d
type: Species
has only substance units: false
name: _BE042354_1_m
is encoded by: hsa:BE042354
is: SBO:0000252
initial concentration: NaN
initial amount: NaN
constant: false
boundary condition: true

metaR PI34P5K
kinetic law: MODEL1310110045#
fast: false
notes: GENE_ASSOCIATION: (8394.1) or (23396.1) or (8395.1) SUBSYSTEM: Inositol phosphate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:10358929,PMID:1850246,PMID:1851250,PMID:2174884,PMID:8042983 NOTES:NCD
is described by: ECO:0000000
name: phosphatidylinositol 3,4-bisphosphate 5-kinase
product: MODEL1310110045#
reactant: MODEL1310110045#
modifier: MODEL1310110045#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.7.1.68
type: Reaction
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110045#_93f773c1_2140_4d22_a459_77753ee7efcb
has only substance units: false
boundary condition: true
is encoded by: hsa:60482
initial concentration: NaN
initial amount: NaN
type: Species
name: SLC5A7
constant: false
is: Q9GZV3
is: SBO:0000252

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is encoded by: hsa:7001
is: P32119
has only substance units: false
type: Species
initial amount: NaN
constant: false
initial concentration: NaN
is: SBO:0000252
name: PRDX2
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110045#_01757a74_ac3a_418f_b1d5_659a6a83c134
initial concentration: NaN
boundary condition: true
is: P30613
constant: false
type: Species
name: PKLR
is encoded by: hsa:5313
is: SBO:0000252
initial amount: NaN
has only substance units: false

metaR CORE4GTg
name: Core 4 beta6-GalNAc-transferase, Golgi apparatus
reactant: MODEL1310110045#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (9245.1) SUBSYSTEM: O-glycan synthesis EC Number: 2.4.1.148 Confidence Level: 0 AUTHORS: PMID:9915862 NOTES:NCD
product: MODEL1310110045#
modifier: MODEL1310110045#
is: SBO:0000176
fast: false
type: Reaction
reversible: false
kinetic law: MODEL1310110045#
is version of: http://identifiers.org/ec-code/2.4.1.102

http://identifiers.org/biomodels.db/MODEL1310110045#_21234b88_3a1b_4aa4_a112_6f68a7c6fd03
name: _AD000092_1_c
has only substance units: false
type: Species
initial amount: NaN
is encoded by: hsa:AD000092
initial concentration: NaN
is: SBO:0000252
constant: false
boundary condition: true

metaM ksii core4 pre9 g
initial concentration: 1.0
is: SBO:0000247
has only substance units: false
initial amount: NaN
type: Species
name: keratan sulfate II biosynthesis, precursor 9
is: CHEBI:28067
constant: false
notes: FORMULA: C83H133N7O64S2X CHARGE: -3
boundary condition: false

metaR THYMt
is described by: ECO:0000269
reactant: MODEL1310110045#
name: thymine reversible transport via facilated diffusion
notes: GENE_ASSOCIATION: (3177.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12006583,PMID:12838422 NOTES:IT
is: SBO:0000185
reversible: true
kinetic law: MODEL1310110045#
product: MODEL1310110045#
fast: false
modifier: MODEL1310110045#
type: Reaction

metaR PI45P5Pn
reactant: MODEL1310110045#
notes: GENE_ASSOCIATION: SUBSYSTEM: Inositol phosphate metabolism EC Number: 3.1.3.36 Confidence Level: 2 AUTHORS: PMID:12728269 NOTES:NCD
is described by: ECO:0000000
is: SBO:0000176
name: phosphatidylinositol-4,5-bisphosphate 5-phosphatase, nuclear
kinetic law: MODEL1310110045#
type: Reaction
reversible: false
product: MODEL1310110045#
fast: false

metaR ECOAH1m
is version of: http://identifiers.org/ec-code/2.3.1.16
reactant: MODEL1310110045#
reversible: true
type: Reaction
product: MODEL1310110045#
modifier: MODEL1310110045#
is version of: http://identifiers.org/ec-code/4.2.1.18
notes: GENE_ASSOCIATION: (549.1) or (3030.1) and (3032.1) or (1892.1) SUBSYSTEM: Tryptophan metabolism EC Number: 4.2.1.17 Confidence Level: 2 AUTHORS: PMID:7558027 NOTES:SAB for mito
is version of: http://identifiers.org/ec-code/4.2.1.17
fast: false
is described by: ECO:0000304
name: 3-hydroxyacyl-CoA dehydratase (3-hydroxybutanoyl-CoA) (mitochondria)
kinetic law: MODEL1310110045#
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110045#_497d70cd_3af9_455e_a7cc_a60f9c2a5524
type: Species
name: CA5B
constant: false
initial amount: NaN
has only substance units: false
is encoded by: hsa:11238
boundary condition: true
is: SBO:0000252
initial concentration: NaN
is: Q9Y2D0

metaR r2112
fast: false
reactant: MODEL1310110045#
is: SBO:0000185
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
type: Reaction
is described by: ECO:0000000
reversible: true
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
kinetic law: MODEL1310110045#
modifier: MODEL1310110045#
product: MODEL1310110045#

ORG:
  orgname: University of Manchester
n:
  given: Neil
  family: Swainston

metaM ksi pre23 g
initial concentration: 1.0
name: keratan sulfate I biosynthesis, precursor 23
constant: false
is: SBO:0000247
type: Species
initial amount: NaN
has only substance units: false
boundary condition: false
notes: FORMULA: C185H296N13O153S7X CHARGE: -8
is: CHEBI:28067

http://identifiers.org/biomodels.db/MODEL1310110045#_1c2770e4_33a4_47a0_b168_e5d4aaaa0559
type: Species
boundary condition: true
initial amount: NaN
is: SBO:0000252
constant: false
initial concentration: NaN
is encoded by: hsa:43
is: P22303
name: ACHE
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110045#_f3c73537_5520_475f_8061_ccf6e7026c2f
is encoded by: hsa:2731
name: GLDC
boundary condition: true
has only substance units: false
type: Species
is: SBO:0000252
initial amount: NaN
is: P23378
initial concentration: NaN
constant: false

metaR r2111
fast: false
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
type: Reaction
is described by: ECO:0000000
reactant: MODEL1310110045#
product: MODEL1310110045#
reversible: true
kinetic law: MODEL1310110045#
is: SBO:0000185
modifier: MODEL1310110045#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110045#_c6dccd09_4f64_4d71_a857_a02a8a07377d
constant: false
type: Species
initial amount: NaN
boundary condition: true
is encoded by: hsa:79087
is: Q9BV10
name: ALG12
has only substance units: false
initial concentration: NaN
is: SBO:0000252

metaM 44mzym r
has only substance units: false
boundary condition: false
is: SBO:0000247
initial concentration: 1.0
is: HMDB01286
initial amount: NaN
type: Species
notes: FORMULA: C29H48O CHARGE: 0 INCHI: InChI=1S/C29H48O/c1-19(2)9-8-10-20(3)22-12-13-23-21-11-14-25-27(4,5)26(30)16-18-29(25,7)24(21)15-17-28(22,23)6/h9,20,22-23,25-26,30H,8,10-18H2,1-7H3/t20-,22-,23+,25+,26+,28-,29-/m1/s1 EHMN_ABBREVIATION: C05108
constant: false
is: CHEBI:18364
name: 14-demethyllanosterol

metaR DOLDPP Ler
type: Reaction
kinetic law: MODEL1310110045#
is: SBO:0000176
reactant: MODEL1310110045#
modifier: MODEL1310110045#
is version of: http://identifiers.org/ec-code/3.6.1.43
is described by: ECO:0000000
fast: false
reversible: false
notes: GENE_ASSOCIATION: (57171.1) SUBSYSTEM: N-glycan synthesis EC Number: 3.6.1.43 Confidence Level: 0 AUTHORS: PMID:12137737 NOTES:NCD
name: Dolichyl-diphosphate phosphohydrolase, human (liver)
product: MODEL1310110045#

metaM 6pgl r
type: Species
initial concentration: 1.0
is: CHEBI:57955
is: HMDB01127
constant: false
initial amount: NaN
has only substance units: false
is: SBO:0000247
notes: FORMULA: C6H9O9P CHARGE: -2 INCHI: InChI=1S/C6H11O9P/c7-3-2(1-14-16(11,12)13)15-6(10)5(9)4(3)8/h2-5,7-9H,1H2,(H2,11,12,13)/p-2/t2-,3-,4+,5-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00733 EHMN_ABBREVIATION: C01236
name: 6-O-phosphonato-D-glucono-1,5-lactone(2-)
boundary condition: false

metaR EX crm hs LPAREN e RPAREN
kinetic law: MODEL1310110045#
reactant: MODEL1310110045#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: N-acylsphingosine exchange
type: Reaction

metaM nh4 x
is: C01342
initial amount: NaN
type: Species
boundary condition: false
initial concentration: 1.0
is: SBO:0000247
has only substance units: false
name: Ammonium
is: CHEBI:28938
constant: false
is: HMDB00051
notes: FORMULA: H4N CHARGE: 1 HEPATONET_1.0_ABBREVIATION: HC00765 EHMN_ABBREVIATION: C01342

metaM succoa x
type: Species
initial amount: NaN
boundary condition: false
name: Succinyl-CoA
is: SBO:0000247
has only substance units: false
constant: false
is: HMDB01022
initial concentration: 1.0
notes: FORMULA: C25H35N7O19P3S CHARGE: -5

metaR PAIL HStn
fast: false
reactant: MODEL1310110045#
is: SBO:0000185
kinetic law: MODEL1310110045#
is described by: ECO:0000000
product: MODEL1310110045#
name: phosphatidylinositol nuclear transport (diffusion)
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 1 AUTHORS: NOTES:
reversible: true

metaM 56dthm m
is: HMDB00079
name: 5,6-dihydrothymine
notes: FORMULA: C5H8N2O2 CHARGE: 0 INCHI: InChI=1S/C5H8N2O2/c1-3-2-6-5(9)7-4(3)8/h3H,2H2,1H3,(H2,6,7,8,9) HEPATONET_1.0_ABBREVIATION: HC00582 EHMN_ABBREVIATION: C00906
initial amount: NaN
initial concentration: 1.0
is: CHEBI:27468
has only substance units: false
type: Species
is: SBO:0000247
boundary condition: false
constant: false

metaM thym m
is: HMDB00262
boundary condition: false
type: Species
has only substance units: false
name: thymine
constant: false
is: SBO:0000247
notes: FORMULA: C5H6N2O2 CHARGE: 0 INCHI: InChI=1S/C5H6N2O2/c1-3-2-6-5(9)7-4(3)8/h2H,1H3,(H2,6,7,8,9) HEPATONET_1.0_ABBREVIATION: HC00170 EHMN_ABBREVIATION: C00178
is: CHEBI:17821
initial amount: NaN
initial concentration: 1.0

metaR r2110
modifier: MODEL1310110045#
reactant: MODEL1310110045#
product: MODEL1310110045#
kinetic law: MODEL1310110045#
is: SBO:0000185
type: Reaction
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
is described by: ECO:0000000
fast: false
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
reversible: true

metaM lnlnca l
initial concentration: 1.0
has only substance units: false
boundary condition: false
is: CHEBI:32387
is: SBO:0000247
constant: false
type: Species
initial amount: NaN
notes: FORMULA: C18H29O2 CHARGE: -1 INCHI: InChI=1S/C18H30O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20/h3-4,6-7,9-10H,2,5,8,11-17H2,1H3,(H,19,20)/p-1/b4-3-,7-6-,10-9- HEPATONET_1.0_ABBREVIATION: HC01758 EHMN_ABBREVIATION: C06427
name: alpha-linolenate
is: HMDB01388

metaR RE2814R
is: SBO:0000176
fast: false
product: MODEL1310110045#
notes: GENE_ASSOCIATION: SUBSYSTEM: Bile acid synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:0 NOTES:
name: RE2814
kinetic law: MODEL1310110045#
reactant: MODEL1310110045#
reversible: true
is described by: ECO:0000000
type: Reaction

metaM tdchola x
constant: false
is: HMDB00951
initial amount: NaN
is: SBO:0000247
is: CHEBI:9407
boundary condition: false
name: taurochenodeoxycholate
has only substance units: false
notes: FORMULA: C26H45NO6S CHARGE: 0 INCHI: InChI=1S/C26H45NO6S/c1-16(4-7-23(30)27-12-13-34(31,32)33)19-5-6-20-24-21(9-11-26(19,20)3)25(2)10-8-18(28)14-17(25)15-22(24)29/h16-22,24,28-29H,4-15H2,1-3H3,(H,27,30)(H,31,32,33)/p-1/t16-,17+,18-,19-,20+,21+,22-,24+,25+,26-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01471 EHMN_ABBREVIATION: C05465
initial concentration: 1.0
type: Species

http://identifiers.org/biomodels.db/MODEL1310110045#_81a0b707_cf71_4c07_baba_023ee46738ea
has only substance units: false
name: DGKZ
initial amount: NaN
boundary condition: true
is: SBO:0000252
constant: false
type: Species
is: G3V0F6
is encoded by: hsa:8525
initial concentration: NaN

metaM acac c
initial concentration: 1.0
notes: FORMULA: C4H5O3 CHARGE: -1 INCHI: InChI=1S/C4H6O3/c1-3(5)2-4(6)7/h2H2,1H3,(H,6,7)/p-1 HEPATONET_1.0_ABBREVIATION: HC00159 EHMN_ABBREVIATION: C00164
is: SBO:0000247
type: Species
initial amount: NaN
is: CHEBI:13705
constant: false
has only substance units: false
boundary condition: false
is: HMDB00060
name: acetoacetate

metaR GLYt7 311 r
reversible: true
notes: GENE_ASSOCIATION: (9152.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12719981 NOTES:SAB
is: SBO:0000185
kinetic law: MODEL1310110045#
modifier: MODEL1310110045#
fast: false
name: glycine reversible transport via sodium and chloride symport (3:1:1)
is described by: ECO:0000006
product: MODEL1310110045#
type: Reaction
reactant: MODEL1310110045#

metaM CE2416 x
name: (2R,6S,10S)-pristanate
boundary condition: false
is: SBO:0000247
initial amount: NaN
constant: false
type: Species
is: CHEBI:57923
notes: FORMULA: C19H37O2 CHARGE: -1 INCHI: InChI=1/C19H38O2/c1-15(2)9-6-10-16(3)11-7-12-17(4)13-8-14-18(5)19(20)21/h15-18H,6-14H2,1-5H3,(H,20,21)/p-1/t16-,17-,18+/m0/s1 EHMN_ABBREVIATION: CE2416
initial concentration: 1.0
has only substance units: false

metaM retfa c
name: fatty acid retinol
has only substance units: false
type: Species
constant: false
is: HMDB00305
initial concentration: 1.0
is: SBO:0000247
is: CHEBI:50211
boundary condition: false
initial amount: NaN
notes: FORMULA: C20H29OFULLR2CO CHARGE: 0

metaR EX dtmp LPAREN e RPAREN
kinetic law: MODEL1310110045#
reactant: MODEL1310110045#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of dTMP(2-)
type: Reaction

metaR r2117
kinetic law: MODEL1310110045#
is described by: ECO:0000000
modifier: MODEL1310110045#
is: SBO:0000185
reversible: true
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
type: Reaction
product: MODEL1310110045#
reactant: MODEL1310110045#
fast: false

metaM h2o2 c
has only substance units: false
is: HMDB03125
is: CHEBI:16240
notes: FORMULA: H2O2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00036 EHMN_ABBREVIATION: C00027
initial concentration: 1.0
initial amount: NaN
constant: false
is: C00027
is: SBO:0000247
name: Hydrogen peroxide
boundary condition: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110045#_fff0cecc_6c04_4bad_b16a_57365c21956f
boundary condition: true
initial amount: NaN
is encoded by: hsa:4715
name: NDUFB9
type: Species
constant: false
is: SBO:0000252
initial concentration: NaN
is: Q9Y6M9
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110045#_ecac8abc_dd15_4efc_982f_cfdb912b0ca3
initial amount: NaN
boundary condition: true
is: SBO:0000252
type: Species
is: P00326
has only substance units: false
is encoded by: hsa:126
initial concentration: NaN
name: ADH1C
constant: false

metaR RE1519M
is: SBO:0000176
reversible: true
name: RE1519
type: Reaction
is version of: http://identifiers.org/ec-code/1.3.3.6
fast: false
kinetic law: MODEL1310110045#
is version of: http://identifiers.org/ec-code/1.3.99.13
modifier: MODEL1310110045#
reactant: MODEL1310110045#
notes: GENE_ASSOCIATION: (33.1) or (51.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.99.13 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:11356167,PMID:8973539 NOTES:
is described by: ECO:0000000
product: MODEL1310110045#

http://identifiers.org/biomodels.db/MODEL1310110045#_5db67a87_a2d4_4ea9_890c_4e2701b8634f
initial amount: NaN
name: PKLR
is encoded by: hsa:5313
has only substance units: false
is: SBO:0000252
constant: false
type: Species
initial concentration: NaN
boundary condition: true

metaR NDPK5n
is version of: http://identifiers.org/ec-code/2.7.4.6
is described by: ECO:0000304
name: nucleoside-diphosphate kinase (ATP:dGDP), nuclear
is: SBO:0000176
modifier: MODEL1310110045#
type: Reaction
reactant: MODEL1310110045#
reversible: true
fast: false
notes: GENE_ASSOCIATION: (4831.1 and 4830.1) or (4830.2 and 4831.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.6 Confidence Level: 4 AUTHORS: PMID:7050910 NOTES:Many nucleoside diphosphates (eight described) can act as acceptors. While many ribo- and deoxyribonucleoside triphosphates can act as donors, only ATP is chosen as a donor to minimize the number of total reactions.. Presence in the nucleus
product: MODEL1310110045#
kinetic law: MODEL1310110045#

metaM sql r
has only substance units: false
initial concentration: 1.0
constant: false
is: HMDB00256
notes: FORMULA: C30H50 CHARGE: 0 INCHI: InChI=1S/C30H50/c1-25(2)15-11-19-29(7)23-13-21-27(5)17-9-10-18-28(6)22-14-24-30(8)20-12-16-26(3)4/h15-18,23-24H,9-14,19-22H2,1-8H3/b27-17+,28-18+,29-23+,30-24+ HEPATONET_1.0_ABBREVIATION: HC00526 EHMN_ABBREVIATION: C00751
name: squalene
boundary condition: false
initial amount: NaN
is: CHEBI:15440
is: SBO:0000247
type: Species

metaM m2mpdol L c
initial concentration: 1.0
type: Species
name: (alpha-D-mannosyl)2-beta-D-mannosyl-diacetylchitobiosyldiphosphodolichol, human liver homolog
notes: FORMULA: C1420H2328N20O320P20 CHARGE: -20
boundary condition: false
is: SBO:0000247
initial amount: NaN
has only substance units: false
constant: false
is: CHEBI:28049

metaM ksi deg1 l
boundary condition: false
constant: false
is: CHEBI:18287
is: HMDB00174
initial amount: NaN
initial concentration: 1.0
type: Species
name: keratan sulfate I, degradation product 1
notes: FORMULA: C241H383N17O209S12X CHARGE: -13
has only substance units: false
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110045#_b204d268_9d6a_49f6_8f23_292feba8273f
has only substance units: false
boundary condition: true
is encoded by: hsa:6241
name: RRM1:RRM2
type: Species
has part: P31350
is: SBO:0000297
constant: false
has part: P23921
initial concentration: NaN
is encoded by: hsa:6240
initial amount: NaN

metaM 5dhf l
is: SBO:0000247
boundary condition: false
constant: false
is: HMDB06487
type: Species
initial amount: NaN
name: pentaglutamyl folate (DHF)
initial concentration: 1.0
has only substance units: false
notes: FORMULA: C39H43N11O18 CHARGE: -6 INCHI: InChI=1/C39H47N11O18/c40-39-49-31-30(33(58)50-39)43-19(16-42-31)15-41-18-3-1-17(2-4-18)32(57)48-24(38(67)68)8-13-28(54)46-22(36(63)64)6-11-26(52)44-20(34(59)60)5-10-25(51)45-21(35(61)62)7-12-27(53)47-23(37(65)66)9-14-29(55)56/h1-4,16,20-24,41H,5-15H2,(H,44,52)(H,45,51)(H,46,54)(H,47,53)(H,48,57)(H,55,56)(H,59,60)(H,61,62)(H,63,64)(H,65,66)(H,67,68)(H3,40,42,49,50,58)/t20-,21-,22-,23-,24-/m0/s1

http://identifiers.org/biomodels.db/MODEL1310110045#_196bac35_21ba_4278_b9f4_2a9375dbb3b8
has only substance units: false
name: GLO1
boundary condition: true
initial amount: NaN
is: SBO:0000252
is encoded by: hsa:2739
constant: false
type: Species
initial concentration: NaN
is: Q04760

metaR r2116
type: Reaction
is: SBO:0000185
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
product: MODEL1310110045#
modifier: MODEL1310110045#
reactant: MODEL1310110045#
fast: false
kinetic law: MODEL1310110045#
reversible: true

metaR RETH2e
product: MODEL1310110045#
type: Reaction
fast: false
name: retinyl ester hydrolase (11-cis), extracellular
kinetic law: MODEL1310110045#
reactant: MODEL1310110045#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Vitamin A metabolism EC Number: Confidence Level: 2 AUTHORS: PMID:1503811 NOTES:IT
is: SBO:0000176
reversible: false

metaR r2115
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
reactant: MODEL1310110045#
type: Reaction
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
is described by: ECO:0000000
reversible: true
fast: false
product: MODEL1310110045#
modifier: MODEL1310110045#
kinetic law: MODEL1310110045#
is: SBO:0000185

ORG:
  orgname: University of Iceland
n:
  given: Ines
  family: Thiele

http://identifiers.org/biomodels.db/MODEL1310110045#_cde2e60a_69f6_48ae_8b58_98984e953b2f
boundary condition: true
name: ELOVL2
constant: false
has only substance units: false
initial concentration: NaN
is encoded by: hsa:54898
initial amount: NaN
is: SBO:0000252
is: Q9NXB9
type: Species

http://identifiers.org/biomodels.db/MODEL1310110045#_b82f627e_03f3_407d_86c7_2e72f5f76625
boundary condition: true
initial concentration: NaN
type: Species
is encoded by: hsa:374907
name: B3GNT8
initial amount: NaN
is: SBO:0000252
constant: false
is: Q7Z7M8
has only substance units: false

metaR PMTCOAtx
fast: false
reactant: MODEL1310110045#
product: MODEL1310110045#
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: NOTES:interaction between peroxisomes and ER (some enzymes on the outer membrane) NJ
name: fatty acid intracellular transport
is: SBO:0000185
type: Reaction
kinetic law: MODEL1310110045#
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110045#_34443983_0f65_4f6f_a8ab_7ecbf87a33cf
initial amount: NaN
type: Species
constant: false
initial concentration: NaN
is encoded by: hsa:257068
boundary condition: true
is: Q0VAA5
name: PLCXD2
has only substance units: false
is: SBO:0000252

metaR CERT1gt
name: ceramide transport protein
modifier: MODEL1310110045#
is described by: ECO:0000304
product: MODEL1310110045#
is version of: http://identifiers.org/ec-code/2.7.11.1
type: Reaction
fast: false
kinetic law: MODEL1310110045#
is: SBO:0000185
reactant: MODEL1310110045#
reversible: true
notes: GENE_ASSOCIATION: (10087.1) SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 2 AUTHORS: PMID:12803919,PMID:14685229,PMID:15596449,PMID:15907394 NOTES:non-vesicular intracellular transport of ceramide

http://identifiers.org/biomodels.db/MODEL1310110045#_b429102f_08de_419e_9f3a_ad423a4ac78d
initial concentration: NaN
has only substance units: false
initial amount: NaN
boundary condition: true
is encoded by: hsa:5805
constant: false
is: Q03393
type: Species
is: SBO:0000252
name: PTS

http://identifiers.org/biomodels.db/MODEL1310110045#_d874b92a_56d1_42b6_9cd6_271f799f1960
type: Species
initial concentration: NaN
is encoded by: hsa:22934
has only substance units: false
boundary condition: true
is: SBO:0000252
constant: false
is: P49247
initial amount: NaN
name: RPIA

metaR TPI
kinetic law: MODEL1310110045#
reversible: true
is version of: http://identifiers.org/ec-code/5.3.1.1
product: MODEL1310110045#
name: triose-phosphate isomerase
is described by: ECO:0000134
fast: false
reactant: MODEL1310110045#
type: Reaction
is: SBO:0000176
notes: GENE_ASSOCIATION: (7167.1) or (286016.1) SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: 5.3.1.1 Confidence Level: 0 AUTHORS: PMID:18456264,PMID:18840520,PMID:2579079,PMID:999837 NOTES:SMP. 18840520 - expression data; 18456264 - protein purification; 2579079 - genetic, homology; 999837 - biochemical
modifier: MODEL1310110045#

metaR GLXtm
is: SBO:0000185
product: MODEL1310110045#
reversible: true
fast: false
type: Reaction
name: glyoxylate transport, mitochondrial
kinetic law: MODEL1310110045#
reactant: MODEL1310110045#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 1 AUTHORS: PMID:15240345 NOTES:NCD
is described by: ECO:0000000

metaR r2114
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
fast: false
product: MODEL1310110045#
type: Reaction
kinetic law: MODEL1310110045#
is: SBO:0000185
is described by: ECO:0000000
reversible: true
reactant: MODEL1310110045#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
modifier: MODEL1310110045#

http://identifiers.org/biomodels.db/MODEL1310110045#_0bcd4e96_333b_43c8_9238_91fd0947ce6b
type: Species
is: SBO:0000252
is: Q6ZWP6
initial amount: NaN
constant: false
is encoded by: hsa:27034
initial concentration: NaN
name: ACAD8
boundary condition: true
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110045#_07971fb4_04eb_46d1_802d_f612a095ccf5
name: CPT1B
is: SBO:0000252
boundary condition: true
initial concentration: NaN
is: B7Z5T8
initial amount: NaN
has only substance units: false
is encoded by: hsa:1375
constant: false
type: Species

metaR EX duri LPAREN e RPAREN
kinetic law: MODEL1310110045#
reactant: MODEL1310110045#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for Deoxyuridine
type: Reaction

metaM retinal 11 cis c
is: SBO:0000247
constant: false
is: HMDB02152
initial amount: NaN
type: Species
boundary condition: false
initial concentration: 1.0
name: 11-cis-retinal
is: CHEBI:16066
has only substance units: false
notes: FORMULA: C20H28O CHARGE: 0 INCHI: InChI=1S/C20H28O/c1-16(8-6-9-17(2)13-15-21)11-12-19-18(3)10-7-14-20(19,4)5/h6,8-9,11-13,15H,7,10,14H2,1-5H3/b9-6-,12-11+,16-8+,17-13+

MODEL1310110045#
species: metaM pi c
species: metaM 1pipdn2c x
species: metaM cholcoads x
species: metaM 3ohdcoa x
species: metaM n3m2masn g
species: metaM pail hs n
initial amount: NaN
species: metaM ha e
species: metaM dpcoa c
species: metaM ethamp c
species: metaM 6pgl r
species: metaM gln L c
species: metaM h2o m
species: metaM 3mldz c
species: metaM HC01434 m
species: metaM thr L e
species: metaM Nacasp m
species: metaM core4 g
species: metaM his L c
species: metaM lnlnca l
stoichiometry: 10.0
species: metaM nm4masn g
species: metaM lnlncg r
species: metaM ksii core4 g
boundary condition: true
species: metaM hexe3coa m
species: metaM pail5p hs n
species: metaM glyc e
species: metaM cholate e
species: metaM udp r
species: metaM pmtcrn r
species: metaM adn e
species: metaM CE5121 m
species: metaM guln c
species: metaM triodthy c
species: metaM udpacgal c
species: metaM atp m
species: metaM ksi pre11 g
species: metaM bilirub r
species: metaM chito2pdol L c
species: metaM 1pyr5c c
species: metaM sphs1p c
species: metaM leuktrB4 e
stoichiometry: 4.0
species: metaM dgchol e
species: metaM CE2418 m
species: metaM HC02213 c
species: metaM n2m2nmn l
species: metaM s2l2n2m2masn l
species: metaM man g
exponent: 1.0
exponent: -1.0
species: metaM 5aop m
species: metaM so3 c
species: metaM CE1943 e
species: metaM m8mpdol L r
species: metaM paps g
species: metaM dolp L r
species: metaM h n
species: metaM gdpfuc g
species: metaM tdchola x
species: metaM prostge1 c
stoichiometry: 20.704451
species: metaM 4hpro LT m
species: metaM gal c
species: metaM f6p c
species: metaM dcsptn1crn c
species: metaM pe hs e
species: metaM tdcoa x
species: metaM arachcoa m
species: metaM C02528 e
species: metaM dopasf e
species: metaM ditp n
species: metaM gln L e
species: metaM bhb e
species: metaM h x
species: metaM mi14p c
species: metaM ac m
species: metaM HC01410 m
species: metaM malt e

metaM h2o2 e
notes: FORMULA: H2O2 CHARGE: 0 INCHI: InChI=1S/H2O2/c1-2/h1-2H HEPATONET_1.0_ABBREVIATION: HC00036 EHMN_ABBREVIATION: C00027
name: hydrogen peroxide
is: SBO:0000247
type: Species
is: HMDB03125
initial amount: NaN
is: CHEBI:16240
initial concentration: 1.0
boundary condition: false
has only substance units: false
constant: false

http://identifiers.org/biomodels.db/MODEL1310110045#_49e0ad05_9eb8_4b38_b9c9_9c036256f630
has only substance units: false
constant: false
boundary condition: true
initial amount: NaN
name: GSTZ1
is: SBO:0000252
type: Species
initial concentration: NaN
is encoded by: hsa:2954
is: O43708

metaR EX 5adtststerones LPAREN e RPAREN
kinetic law: MODEL1310110045#
reactant: MODEL1310110045#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 5alpha-Dihydrotestosterone sulfate exchange
type: Reaction

metaR PALFATPtc
kinetic law: MODEL1310110045#
product: MODEL1310110045#
reactant: MODEL1310110045#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: uptake of Hexadecanoate by the enterocytes
type: Reaction

metaM xu1p D c
notes: FORMULA: C5H9O8P CHARGE: -2 INCHI: InChI=1/C5H11O8P/c6-1-3(7)5(9)4(8)2-13-14(10,11)12/h3,5-7,9H,1-2H2,(H2,10,11,12)/t3-,5-/m1/s1
has only substance units: false
boundary condition: false
initial amount: NaN
initial concentration: 1.0
name: D-Xylulose 1-phosphate
is: SBO:0000247
type: Species
is: HMDB06534
constant: false

http://identifiers.org/biomodels.db/MODEL1310110045#_121cbd4f_e31b_4948_b317_fbc401d55995
constant: false
is encoded by: hsa:55350
initial amount: NaN
name: VNN3:VNN2:VNN1
type: Species
initial concentration: NaN
boundary condition: true
is: SBO:0000297
has only substance units: false

metaR TSULt4 3
name: thiosulfate transport via sodium symport
fast: false
reversible: true
is: SBO:0000185
notes: GENE_ASSOCIATION: (6561.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10811962,PMID:11161786 NOTES:NCD
reactant: MODEL1310110045#
is described by: ECO:0000269
product: MODEL1310110045#
kinetic law: MODEL1310110045#
type: Reaction
modifier: MODEL1310110045#

http://identifiers.org/biomodels.db/MODEL1310110045#_deb8b556_9855_47f4_8f2e_6580f2383b3b
has only substance units: false
constant: false
initial concentration: NaN
is: Q4FEB3
boundary condition: true
is encoded by: hsa:1215
name: CMA1
type: Species
initial amount: NaN
is: SBO:0000252

metaR S2L2FN2M2MASNtly
type: Reaction
name: s2l2fn2m2masn transport, extracellular to lysosome
product: MODEL1310110045#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD
fast: false
reversible: false
kinetic law: MODEL1310110045#
is described by: ECO:0000000
is: SBO:0000185
reactant: MODEL1310110045#

metaR UDPtl
fast: false
is described by: ECO:0000000
kinetic law: MODEL1310110045#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 1 AUTHORS: NOTES:unknown mechanism for transport - not known if it is energy dependent or not, recycling and IC transport is important to get it to other areas of the cell (e.g. plasma membrane) - translocators have been found for ER and Golgi - none found for lysosome yet so non-mechanistic transporter added - in future this will need to be revised _when_ a translocator is found NJ
reactant: MODEL1310110045#
is: SBO:0000185
product: MODEL1310110045#
type: Reaction
name: udp intracellular transport
reversible: true

metaM c14dccoa x
is: SBO:0000247
has only substance units: false
type: Species
notes: FORMULA: C35H55N7O19P3S CHARGE: -5
is: HMDB02288
initial concentration: 1.0
initial amount: NaN
constant: false
boundary condition: false
name: tetradecanedioylcoa

metaR TCYNTtm
reversible: false
kinetic law: MODEL1310110045#
type: Reaction
fast: false
is described by: ECO:0000000
name: Thiocyanate transport via diffusion (mitochondrial)
product: MODEL1310110045#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: PMID:6351723 NOTES:thiocyanate is found excreted in urine (PMID: 6351723) MM
is: SBO:0000185
reactant: MODEL1310110045#

metaR APOC LYS BTNP
reversible: false
product: MODEL1310110045#
type: Reaction
is: SBO:0000176
kinetic law: MODEL1310110045#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Biotin metabolism EC Number: Confidence Level: 2 AUTHORS: NOTES:
is described by: ECO:0000000
reactant: MODEL1310110045#
name: proteolysis of apoC-Lys-btn

metaM thym c
is: C00178
initial concentration: 1.0
initial amount: NaN
is: SBO:0000247
name: Thymine
notes: FORMULA: C5H6N2O2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00170 EHMN_ABBREVIATION: C00178
has only substance units: false
type: Species
constant: false
boundary condition: false
is: CHEBI:17821
is: HMDB00262

metaM 56dthm c
has only substance units: false
is: CHEBI:27468
is: SBO:0000247
name: 5,6-dihydrothymine
type: Species
initial concentration: 1.0
is: HMDB00079
notes: FORMULA: C5H8N2O2 CHARGE: 0 INCHI: InChI=1S/C5H8N2O2/c1-3-2-6-5(9)7-4(3)8/h3H,2H2,1H3,(H2,6,7,8,9) HEPATONET_1.0_ABBREVIATION: HC00582 EHMN_ABBREVIATION: C00906
initial amount: NaN
constant: false
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110045#_9b1a6d16_40e5_4845_be1f_27f8f8795671
name: NDUFB7
constant: false
has only substance units: false
type: Species
boundary condition: true
is: P17568
is: SBO:0000252
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:4713

metaR FAOXC226C205m
kinetic law: MODEL1310110045#
product: MODEL1310110045#
reactant: MODEL1310110045#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C22:6-->C20:5)m
type: Reaction

metaM nh4 m
is: HMDB00051
constant: false
initial concentration: 1.0
is: CHEBI:28938
name: Ammonium
is: SBO:0000247
initial amount: NaN
has only substance units: false
notes: FORMULA: H4N CHARGE: 1 HEPATONET_1.0_ABBREVIATION: HC00765 EHMN_ABBREVIATION: C01342
type: Species
boundary condition: false
is: C01342

metaR RE2814M
is: SBO:0000176
reactant: MODEL1310110045#
product: MODEL1310110045#
type: Reaction
name: RE2814
fast: false
reversible: true
kinetic law: MODEL1310110045#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Bile acid synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:0 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110045#_c075bb79_60a8_4642_8161_ad848975cb05
boundary condition: true
is: SBO:0000252
constant: false
initial amount: NaN
is: O00154
name: ACOT7
initial concentration: NaN
has only substance units: false
is encoded by: hsa:11332
type: Species

metaM ksii core2 deg1 l
name: keratan sulfate II (core 2-linked), degradation product 1
boundary condition: false
notes: FORMULA: C70H113N5O59S3X CHARGE: -3
is: HMDB00868
is: SBO:0000247
constant: false
type: Species
initial concentration: 1.0
has only substance units: false
initial amount: NaN
is: CHEBI:57737

http://identifiers.org/biomodels.db/MODEL1310110045#_3d4d04ae_9f03_4787_b470_fb94e33be992
is: Q8WUX1
constant: false
is: SBO:0000252
is encoded by: hsa:92745
boundary condition: true
type: Species
has only substance units: false
initial amount: NaN
initial concentration: NaN
name: SLC38A5

http://identifiers.org/biomodels.db/MODEL1310110045#_8b0cd3c8_7682_4fbe_b8db_b4ab3d0aee52
initial concentration: NaN
constant: false
boundary condition: true
has only substance units: false
type: Species
name: DEGS1
initial amount: NaN
is: O15121
is: SBO:0000252
is encoded by: hsa:8560

metaR GLXtp
kinetic law: MODEL1310110045#
name: glyoxylate transport, peroxisomal
fast: false
reactant: MODEL1310110045#
type: Reaction
product: MODEL1310110045#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 1 AUTHORS: PMID:15240345 NOTES:NCD
reversible: true
is described by: ECO:0000000
is: SBO:0000185

metaM lgt S c
is: HMDB01066
notes: FORMULA: C13H20N3O8S CHARGE: -1 INCHI: InChI=1S/C13H21N3O8S/c1-6(17)13(24)25-5-8(11(21)15-4-10(19)20)16-9(18)3-2-7(14)12(22)23/h6-8,17H,2-5,14H2,1H3,(H,15,21)(H,16,18)(H,19,20)(H,22,23)/p-1/t6-,7+,8+/m1/s1
initial amount: NaN
has only substance units: false
constant: false
is: SBO:0000247
type: Species
name: (R)-S-lactoylglutathionate(1-)
initial concentration: 1.0
is: CHEBI:57474
boundary condition: false

metaM acac e
initial amount: NaN
is: HMDB00060
constant: false
is: CHEBI:13705
notes: FORMULA: C4H5O3 CHARGE: -1 INCHI: InChI=1S/C4H6O3/c1-3(5)2-4(6)7/h2H2,1H3,(H,6,7)/p-1 HEPATONET_1.0_ABBREVIATION: HC00159 EHMN_ABBREVIATION: C00164
is: SBO:0000247
initial concentration: 1.0
has only substance units: false
boundary condition: false
type: Species
name: acetoacetate

metaR EX maltpt LPAREN e RPAREN
kinetic law: MODEL1310110045#
reactant: MODEL1310110045#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: maltopentaose exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110045#_784cf1af_1090_4c58_897b_12d69ac1c5e9
type: Species
is: B4DG68
constant: false
is: SBO:0000252
is encoded by: hsa:4842
initial concentration: NaN
name: NOS1
has only substance units: false
boundary condition: true
initial amount: NaN

metaR SUCD1m
notes: GENE_ASSOCIATION: (6389.1 and 6392.1 and 6391.1 and 6390.1) SUBSYSTEM: Citric acid cycle EC Number: 1.3.99.1 Confidence Level: 0 AUTHORS: PMID:6945861 NOTES:NCD. Biochemical, Genetic
product: MODEL1310110045#
kinetic law: MODEL1310110045#
fast: false
is: SBO:0000176
name: succinate dehydrogenase
reactant: MODEL1310110045#
is version of: http://identifiers.org/ec-code/1.3.5.1
type: Reaction
is described by: ECO:0000134
modifier: MODEL1310110045#
reversible: true

metaM lnlnca r
initial amount: NaN
boundary condition: false
has only substance units: false
constant: false
is: HMDB01388
is: SBO:0000247
initial concentration: 1.0
type: Species
is: CHEBI:32387
name: alpha-linolenate
notes: FORMULA: C18H29O2 CHARGE: -1 INCHI: InChI=1S/C18H30O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20/h3-4,6-7,9-10H,2,5,8,11-17H2,1H3,(H,19,20)/p-1/b4-3-,7-6-,10-9- HEPATONET_1.0_ABBREVIATION: HC01758 EHMN_ABBREVIATION: C06427

http://identifiers.org/biomodels.db/MODEL1310110045#_6b8f2738_761d_4f8f_9b61_8190640088f4
is: SBO:0000252
initial amount: NaN
initial concentration: NaN
name: _AI631997_1_m
type: Species
boundary condition: true
constant: false
has only substance units: false
is encoded by: hsa:AI631997

metaM strdnccoa m
has only substance units: false
boundary condition: false
initial amount: NaN
constant: false
is: C16163
is: HMDB06519
initial concentration: 1.0
is: http://identifiers.org/pubchem.compound/47205473
name: stearidonyl coenzyme A
type: Species
notes: FORMULA: C39H58N7O17P3S CHARGE: -4 INCHI: InChI=1/C39H62N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-30(48)67-23-22-41-29(47)20-21-42-37(51)34(50)39(2,3)25-60-66(57,58)63-65(55,56)59-24-28-33(62-64(52,53)54)32(49)38(61-28)46-27-45-31-35(40)43-26-44-36(31)46/h5-6,8-9,11-12,14-15,26-28,32-34,38,49-50H,4,7,10,13,16-25H2,1-3H3,(H,41,47)(H,42,51)(H,55,56)(H,57,58)(H2,40,43,44)(H2,52,53,54)/b6-5-,9-8-,12-11-,15-14-/t28-,32-,33?,34+,38-/m1/s1
is: SBO:0000247

metaR FAOXC8DCC6DCx
kinetic law: MODEL1310110045#
product: MODEL1310110045#
reactant: MODEL1310110045#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C8DC-->C6DC)x
type: Reaction

metaM 5dhf m
constant: false
is: SBO:0000247
name: pentaglutamyl folate (DHF)
type: Species
is: HMDB06487
initial amount: NaN
initial concentration: 1.0
has only substance units: false
boundary condition: false
notes: FORMULA: C39H43N11O18 CHARGE: -6 INCHI: InChI=1/C39H47N11O18/c40-39-49-31-30(33(58)50-39)43-19(16-42-31)15-41-18-3-1-17(2-4-18)32(57)48-24(38(67)68)8-13-28(54)46-22(36(63)64)6-11-26(52)44-20(34(59)60)5-10-25(51)45-21(35(61)62)7-12-27(53)47-23(37(65)66)9-14-29(55)56/h1-4,16,20-24,41H,5-15H2,(H,44,52)(H,45,51)(H,46,54)(H,47,53)(H,48,57)(H,55,56)(H,59,60)(H,61,62)(H,63,64)(H,65,66)(H,67,68)(H3,40,42,49,50,58)/t20-,21-,22-,23-,24-/m0/s1

metaM nh4 n
notes: FORMULA: H4N CHARGE: 1 INCHI: InChI=1S/H3N/h1H3/p+1 HEPATONET_1.0_ABBREVIATION: HC00765 EHMN_ABBREVIATION: C01342
constant: false
is: HMDB00051
is: SBO:0000247
initial amount: NaN
is: CHEBI:28938
boundary condition: false
name: ammonium
type: Species
has only substance units: false
initial concentration: 1.0

metaR r2119
product: MODEL1310110045#
modifier: MODEL1310110045#
is described by: ECO:0000000
is: SBO:0000185
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
reversible: true
type: Reaction
fast: false
reactant: MODEL1310110045#
kinetic law: MODEL1310110045#

metaR LDH L
reversible: true
type: Reaction
kinetic law: MODEL1310110045#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (3945.1 and 3939.1) or (160287.1) or (3948.2) or (3939.1) or (3948.1) or (55293.1) or (3945.1) or (92483.1) SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: 1.1.1.27 Confidence Level: 0 AUTHORS: PMID:11377399,PMID:15240094,PMID:2440048 NOTES:Also see LDL_D
is version of: http://identifiers.org/ec-code/1.1.1.27
name: L-lactate dehydrogenase
product: MODEL1310110045#
fast: false
reactant: MODEL1310110045#
modifier: MODEL1310110045#
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110045#_b1cae3d2_d125_436d_9421_d9608b9edae6
is: SBO:0000252
has only substance units: false
is: Q9NY65
initial concentration: NaN
boundary condition: true
constant: false
type: Species
initial amount: NaN
name: EHHADH
is encoded by: hsa:1962

http://identifiers.org/biomodels.db/MODEL1310110045#_eb5d5ff8_a6d2_48b8_894d_ecd116290d0f
has only substance units: false
type: Species
initial concentration: NaN
constant: false
name: HMGCR
is encoded by: hsa:3156
is: SBO:0000252
is: P04035
initial amount: NaN
boundary condition: true

metaR NADS2
type: Reaction
kinetic law: MODEL1310110045#
is version of: http://identifiers.org/ec-code/6.3.5.1
product: MODEL1310110045#
modifier: MODEL1310110045#
notes: GENE_ASSOCIATION: (55191.1) SUBSYSTEM: NAD metabolism EC Number: Confidence Level: 4 AUTHORS: NOTES:
fast: false
name: NAD synthase (glutamine-hydrolysing)
reactant: MODEL1310110045#
reversible: false
is described by: ECO:0000269
is: SBO:0000176

metaM ksii core4 pre3 g
is: CHEBI:58053
boundary condition: false
constant: false
name: keratan sulfate II biosynthesis, precursor 3
type: Species
is: HMDB00175
is: SBO:0000247
notes: FORMULA: C55H89N5O38X CHARGE: -1
initial amount: NaN
is: C00130
has only substance units: false
initial concentration: 1.0

metaR EX lac D LPAREN e RPAREN
kinetic law: MODEL1310110045#
reactant: MODEL1310110045#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: D-lactate exchange
type: Reaction

metaM thym e
initial amount: NaN
name: thymine
is: SBO:0000247
initial concentration: 1.0
notes: FORMULA: C5H6N2O2 CHARGE: 0 INCHI: InChI=1S/C5H6N2O2/c1-3-2-6-5(9)7-4(3)8/h2H,1H3,(H2,6,7,8,9) HEPATONET_1.0_ABBREVIATION: HC00170 EHMN_ABBREVIATION: C00178
type: Species
constant: false
has only substance units: false
is: CHEBI:17821
is: HMDB00262
boundary condition: false

metaR r0639
fast: false
name: Lauroyl-CoA:acetyl-CoA C-acyltransferase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:2.3.1.16
product: MODEL1310110045#
kinetic law: MODEL1310110045#
is described by: ECO:0000000
reactant: MODEL1310110045#
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.16 Confidence Level: 0 AUTHORS: PMID:1121274,PMID:1679347,PMID:3194209,PMID:6378901,PMID:8241273 NOTES:
reversible: false
is: SBO:0000176
type: Reaction

metaM ksi pre24 g
notes: FORMULA: C191H306N13O158S7X CHARGE: -8
is: CHEBI:58053
is: SBO:0000247
boundary condition: false
constant: false
is: HMDB00175
is: C00130
type: Species
name: keratan sulfate I biosynthesis, precursor 24
initial amount: NaN
has only substance units: false
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110045#_ce82d419_c728_49e3_abfe_442950e74315
type: Species
initial amount: NaN
boundary condition: true
constant: false
is: Q9NY97
initial concentration: NaN
name: B3GNT2
has only substance units: false
is: SBO:0000252
is encoded by: hsa:10678

metaM fpram c
is: C04640
name: 2-(Formamido)-N1-(5-phospho-D-ribosyl)acetamidine
type: Species
notes: FORMULA: C8H15N3O8P CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC01329 EHMN_ABBREVIATION: C04640
constant: false
is: CHEBI:58478
has only substance units: false
initial concentration: 1.0
initial amount: NaN
is: SBO:0000247
is: HMDB06211
boundary condition: false

metaR r2118
reversible: true
type: Reaction
is: SBO:0000185
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
modifier: MODEL1310110045#
is described by: ECO:0000000
fast: false
reactant: MODEL1310110045#
kinetic law: MODEL1310110045#
product: MODEL1310110045#

metaM ksi pre9 g
initial amount: NaN
is: SBO:0000247
is: CHEBI:58053
is: HMDB00175
constant: false
type: Species
notes: FORMULA: C121H196N8O93S2X CHARGE: -3
is: C00130
boundary condition: false
name: keratan sulfate I biosynthesis, precursor 9
initial concentration: 1.0
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110045#_65985051_73d2_4006_86a2_7f902af9fe9f
is: SBO:0000252
boundary condition: true
initial concentration: NaN
type: Species
has only substance units: false
constant: false
is encoded by: hsa:30
initial amount: NaN
name: ACAA1
is: Q96CA6

metaR EX leu L LPAREN e RPAREN
kinetic law: MODEL1310110045#
reactant: MODEL1310110045#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: L-Leucine exchange
type: Reaction

metaM cdpdag hs m
is: SBO:0000247
initial concentration: 1.0
name: CDP-diacylglycerol(2-)
has only substance units: false
notes: FORMULA: C12H17N3O11P2FULLRCO2FULLR2CO2 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC02078
initial amount: NaN
is: CHEBI:58332
boundary condition: false
type: Species
constant: false

metaR EX leuktrB4 LPAREN e RPAREN
kinetic law: MODEL1310110045#
reactant: MODEL1310110045#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: leukotriene B4 exchange
type: Reaction

metaR SARDHm
notes: GENE_ASSOCIATION: (1757.1) SUBSYSTEM: Urea cycle EC Number: 1.5.99.2 Confidence Level: 4 AUTHORS: PMID:10444331 NOTES:SAB EC # is questionable overall reaction is questionable
reversible: false
is described by: ECO:0000269
reactant: MODEL1310110045#
name: Sarcosine dehydrogenase (m)
fast: false
type: Reaction
product: MODEL1310110045#
modifier: MODEL1310110045#
is version of: http://identifiers.org/ec-code/1.5.99.1
kinetic law: MODEL1310110045#
is: SBO:0000176

metaR CLPNDt
reactant: MODEL1310110045#
fast: false
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11788354,PMID:12864740 NOTES:NJ
type: Reaction
reversible: true
product: MODEL1310110045#
is: SBO:0000185
kinetic law: MODEL1310110045#
name: fatty acid transport via diffusion

http://identifiers.org/biomodels.db/MODEL1310110045#_cbd7c5eb_dd71_487d_977e_611255eba966
initial amount: NaN
boundary condition: true
is encoded by: hsa:AI934540
type: Species
name: _AI934540_1_c
constant: false
initial concentration: NaN
has only substance units: false
is: SBO:0000252

metaR r0022
kinetic law: MODEL1310110045#
product: MODEL1310110045#
is version of: http://identifiers.org/ec-code/1.8.1.7
notes: GENE_ASSOCIATION: (AA532636.1) or (2936.1) SUBSYSTEM: Glutathione metabolism EC Number: 1.8.1.7 Confidence Level: 0 AUTHORS: PMID:10781871,PMID:12821209,PMID:237878,PMID:31912,PMID:4380255,PMID:8981046,PMID:9621574 NOTES:
is described by: ECO:0000000
reactant: MODEL1310110045#
fast: false
modifier: MODEL1310110045#
reversible: true
type: Reaction
name: glutathione:NAD+ oxidoreductase Glutamate metabolism EC:1.8.1.7
is: SBO:0000176

metaM prostgh2 r
is: CHEBI:57405
notes: FORMULA: C20H31O5 CHARGE: -1 INCHI: InChI=1S/C20H32O5/c1-2-3-6-9-15(21)12-13-17-16(18-14-19(17)25-24-18)10-7-4-5-8-11-20(22)23/h4,7,12-13,15-19,21H,2-3,5-6,8-11,14H2,1H3,(H,22,23)/p-1/b7-4-,13-12+/t15-,16+,17+,18-,19+/m0/s1 EHMN_ABBREVIATION: C00427
initial concentration: 1.0
boundary condition: false
type: Species
is: HMDB01381
is: SBO:0000247
constant: false
has only substance units: false
initial amount: NaN
name: prostaglandin H2(1-)

metaR EX digalsgalside hs LPAREN e RPAREN
kinetic law: MODEL1310110045#
reactant: MODEL1310110045#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Digalactosylceramidesulfate exchange
type: Reaction

metaM dhbpt c
has only substance units: false
constant: false
initial amount: NaN
is: CHEBI:20680
notes: FORMULA: C9H13N5O3 CHARGE: 0 INCHI: InChI=1S/C9H13N5O3/c1-3(15)6(16)4-2-11-7-5(12-4)8(17)14-9(10)13-7/h3-4,6,15-16H,2H2,1H3,(H3,10,11,13,14,17) HEPATONET_1.0_ABBREVIATION: HC00242 EHMN_ABBREVIATION: C00268
is: HMDB00038
name: 6,7-dihydrobiopterin
boundary condition: false
is: SBO:0000247
initial concentration: 1.0
type: Species

metaM digalsgalside hs g
is: C06127
is: http://identifiers.org/pubchem.compound/8384
initial amount: NaN
boundary condition: false
initial concentration: 1.0
is: SBO:0000247
type: Species
has only substance units: false
constant: false
name: Digalactosylceramidesulfate
notes: FORMULA: C30H55NO15SFULLRCO CHARGE: -1 EHMN_ABBREVIATION: C06127

metaM pail5p hs n
type: Species
has only substance units: false
initial concentration: 1.0
name: 1-phosphatidyl-1D-myo-inositol 5-phosphate(3-)
initial amount: NaN
is: CHEBI:57795
is: SBO:0000247
constant: false
notes: FORMULA: C9H15O12P2FULLRCO2FULLR2CO2 CHARGE: -3
boundary condition: false

metaM HC02208 c
type: Species
is: SBO:0000247
is: CHEBI:27696
name: prostaglandin-d1
has only substance units: false
notes: FORMULA: C20H33O5 CHARGE: -1 INCHI: InChI=1S/C20H34O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h12-13,15-18,21-22H,2-11,14H2,1H3,(H,24,25)/b13-12+/t15-,16+,17+,18-/m0/s1
initial concentration: 1.0
constant: false
initial amount: NaN
boundary condition: false

metaR r1860
modifier: MODEL1310110045#
reversible: false
reactant: MODEL1310110045#
product: MODEL1310110045#
type: Reaction
fast: false
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
name: Y+LAT2 Utilized transport
is: SBO:0000185
kinetic law: MODEL1310110045#
is described by: ECO:0000000

metaR DM Asn X Ser Thr ly
kinetic law: MODEL1310110045#
reactant: MODEL1310110045#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 0 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: false
name: DM Asn-X-Ser/Thr(ly)
type: Reaction

metaM dadp c
is: HMDB01508
type: Species
name: dADP
boundary condition: false
is: C00206
initial amount: NaN
is: CHEBI:57667
notes: FORMULA: C10H12N5O9P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00192 EHMN_ABBREVIATION: C00206
has only substance units: false
constant: false
initial concentration: 1.0
is: SBO:0000247

metaM galside hs e
initial amount: NaN
constant: false
is: SBO:0000247
type: Species
has only substance units: false
initial concentration: 1.0
name: D-galactosyl-N-acylsphingosine
is: CHEBI:12947
notes: FORMULA: C24H46NO7FULLRCO CHARGE: 0 EHMN_ABBREVIATION: C02686
boundary condition: false

metaR THYOXt
product: MODEL1310110045#
type: Reaction
is described by: ECO:0000269
is: SBO:0000185
name: T4 transport via bicarbonate countertransport
reversible: true
fast: false
kinetic law: MODEL1310110045#
notes: GENE_ASSOCIATION: (53919.1) or (6579.1) or (28231.1) or (10599.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12507753,PMID:9007731,PMID:9334206 NOTES:NJ
reactant: MODEL1310110045#
modifier: MODEL1310110045#

http://identifiers.org/biomodels.db/MODEL1310110045#_4952693e_a4e8_404a_8435_cb90a1d4a85e
type: Species
initial amount: NaN
is encoded by: hsa:8897
name: MTMR3
is: Q13615
has only substance units: false
is: SBO:0000252
initial concentration: NaN
boundary condition: true
constant: false

metaR r0021
notes: GENE_ASSOCIATION: (AV717590.1) or (953.1) or (954.1) or (956.1) or (377841.1) SUBSYSTEM: Glutathione metabolism EC Number: 1.8.1.7 Confidence Level: 0 AUTHORS: PMID:10781871,PMID:12821209,PMID:237878,PMID:31912,PMID:4380255,PMID:8981046,PMID:9621574 NOTES:IT - fixed proton
kinetic law: MODEL1310110045#
is described by: ECO:0000000
name: glutathione:NAD+ oxidoreductase Glutamate metabolism EC:1.8.1.7
is version of: http://identifiers.org/ec-code/3.6.1.5
fast: false
type: Reaction
product: MODEL1310110045#
is: SBO:0000176
modifier: MODEL1310110045#
reversible: true
reactant: MODEL1310110045#

metaM clpnd c
name: clupanodonic acid
is: SBO:0000247
is: CHEBI:53488
initial concentration: 1.0
initial amount: NaN
has only substance units: false
is: HMDB06528
type: Species
constant: false
notes: FORMULA: C22H33O2 CHARGE: -1 INCHI: InChI=1S/C22H34O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22(23)24/h3-4,6-7,9-10,12-13,15-16H,2,5,8,11,14,17-21H2,1H3,(H,23,24)/b4-3-,7-6-,10-9-,13-12-,16-15-
boundary condition: false

metaR MM5cg
type: Reaction
fast: false
is described by: ECO:0000000
name: mannosyl-oligosaccharide 1,2-alpha-mannosidase, Golgi apparatus
notes: GENE_ASSOCIATION: (4121.1) or (57134.1) or (10905.1) SUBSYSTEM: N-glycan synthesis EC Number: 3.2.1.113 Confidence Level: 0 AUTHORS: PMID:10915796,PMID:9592125 NOTES:NCD
is version of: http://identifiers.org/ec-code/3.2.1.113
reactant: MODEL1310110045#
product: MODEL1310110045#
modifier: MODEL1310110045#
reversible: false
kinetic law: MODEL1310110045#
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110045#_7cef710d_442a_42e3_8d56_1f92d5d62186
boundary condition: true
is: SBO:0000252
has only substance units: false
is: P09417
constant: false
initial concentration: NaN
type: Species
is encoded by: hsa:5860
initial amount: NaN
name: QDPR

http://identifiers.org/biomodels.db/MODEL1310110045#_a896a54c_4571_49de_91c9_ab37be974ec4
type: Species
is: SBO:0000252
initial amount: NaN
initial concentration: NaN
is: B7Z7I0
has only substance units: false
constant: false
is encoded by: hsa:8277
name: TKTL1
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110045#_6aff2e0b_bbe1_4542_bedd_31e8afd57b99
boundary condition: true
is encoded by: hsa:4698
type: Species
has only substance units: false
initial amount: NaN
is: SBO:0000252
constant: false
initial concentration: NaN
is: Q16718
name: NDUFA5

metaR EX dhap LPAREN e RPAREN
kinetic law: MODEL1310110045#
reactant: MODEL1310110045#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of glycerone phosphate(2-)
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110045#_ccc54d09_a0ae_4a96_abcf_11daf2dc7f68
has only substance units: false
name: ODC1
is: SBO:0000252
constant: false
type: Species
boundary condition: true
initial amount: NaN
is encoded by: hsa:4953
is: P11926
initial concentration: NaN

metaM xyl D e
initial concentration: 1.0
name: aldehydo-D-xylose
has only substance units: false
boundary condition: false
is: CHEBI:15936
constant: false
notes: FORMULA: C5H10O5 CHARGE: 0 INCHI: InChI=1S/C5H10O5/c6-1-3(8)5(10)4(9)2-7/h1,3-5,7-10H,2H2/t3-,4+,5+/m0/s1
is: SBO:0000247
initial amount: NaN
type: Species

http://identifiers.org/biomodels.db/MODEL1310110045#_e08d63df_1256_4077_9546_4564c2d7b7b7
initial amount: NaN
name: NDUFC1
boundary condition: true
has only substance units: false
is encoded by: hsa:4717
is: O43677
type: Species
is: SBO:0000252
constant: false
initial concentration: NaN

metaR r0339
kinetic law: MODEL1310110045#
is version of: http://identifiers.org/ec-code/3.1.2.22
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.1.2.2
is version of: http://identifiers.org/ec-code/2.3.1.65
modifier: MODEL1310110045#
name: ATP:(R)-glycerate 3-phosphotransferase Glycine, serine and threonine metabolism EC:2.7.1.31
notes: GENE_ASSOCIATION: (10965.1) or (122970.1) or (11332.1) or (570.1) or (80864.1) or (83715.1) or (5538.1) or (9374.1) or (R33828.1) SUBSYSTEM: Unassigned EC Number: 2.7.1.31 Confidence Level: 0 AUTHORS: PMID:16753811,PMID:216417,PMID:2537226,PMID:6252205 NOTES:
fast: false
product: MODEL1310110045#
reactant: MODEL1310110045#
is described by: ECO:0000000
reversible: false
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110045#_dc3ef078_091f_4e88_bc26_cda8f0b5c67b
name: CHST3
type: Species
has only substance units: false
is: SBO:0000252
is encoded by: hsa:9469
initial amount: NaN
initial concentration: NaN
boundary condition: true
constant: false
is: Q7LGC8

metaR KSII CORE2tly
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 2 AUTHORS: NOTES:
reversible: false
reactant: MODEL1310110045#
is described by: ECO:0000000
type: Reaction
name: keratan sulfate II (core 2) transport, extracellular to lysosome
kinetic law: MODEL1310110045#
is: SBO:0000185
fast: false
product: MODEL1310110045#

metaM 5htrp c
has only substance units: false
name: 5-hydroxy-L-tryptophan
is: CHEBI:17780
is: HMDB00472
notes: FORMULA: C11H12N2O3 CHARGE: 0 INCHI: InChI=1S/C11H12N2O3/c12-9(11(15)16)3-6-5-13-10-2-1-7(14)4-8(6)10/h1-2,4-5,9,13-14H,3,12H2,(H,15,16)/t9-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00472 EHMN_ABBREVIATION: C00643
is: SBO:0000247
type: Species
constant: false
boundary condition: false
initial amount: NaN
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110045#_50b10816_52c1_4afb_977b_962b4e21d299
type: Species
is encoded by: hsa:FLJ44968
constant: false
is: SBO:0000252
has only substance units: false
boundary condition: true
name: _FLJ44968_1_m
initial concentration: NaN
initial amount: NaN

metaM asp D e
boundary condition: false
name: D-aspartate(1-)
is: SBO:0000247
initial amount: NaN
notes: FORMULA: C4H6NO4 CHARGE: -1 INCHI: InChI=1S/C4H7NO4/c5-2(4(8)9)1-3(6)7/h2H,1,5H2,(H,6,7)(H,8,9)/p-1/t2-/m1/s1
type: Species
has only substance units: false
initial concentration: 1.0
is: CHEBI:29990
constant: false
is: HMDB06483

http://identifiers.org/biomodels.db/MODEL1310110045#_c6f023cc_72cf_4cac_ad0b_08abb7375332
is: O75521
constant: false
type: Species
has only substance units: false
initial concentration: NaN
initial amount: NaN
is: SBO:0000252
boundary condition: true
name: ECI2
is encoded by: hsa:10455

metaM digalsgalside hs e
has only substance units: false
is: C06127
is: http://identifiers.org/pubchem.compound/8384
type: Species
notes: FORMULA: C30H55NO15SFULLRCO CHARGE: -1 EHMN_ABBREVIATION: C06127
name: Digalactosylceramidesulfate
is: SBO:0000247
initial concentration: 1.0
constant: false
initial amount: NaN
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110045#_830631a2_a4d6_4c50_8db6_47edee0aacf8
is: SBO:0000252
is encoded by: hsa:6817
is: P50225
initial amount: NaN
initial concentration: NaN
type: Species
has only substance units: false
name: SULT1A1
constant: false
boundary condition: true

metaM galside hs c
notes: FORMULA: C24H46NO7FULLRCO CHARGE: 0 EHMN_ABBREVIATION: C02686
initial amount: NaN
constant: false
is: SBO:0000247
name: D-galactosyl-N-acylsphingosine
initial concentration: 1.0
is: CHEBI:12947
boundary condition: false
has only substance units: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110045#_b4a83195_8325_4d60_b401_c79008693d04
constant: false
is encoded by: hsa:2752
initial amount: NaN
boundary condition: true
is: P15104
initial concentration: NaN
is: SBO:0000252
type: Species
has only substance units: false
name: GLUL

metaR MALTt1r
product: MODEL1310110045#
modifier: MODEL1310110045#
reversible: true
name: maltose transport (uniport)
type: Reaction
is described by: ECO:0000269
fast: false
kinetic law: MODEL1310110045#
is: SBO:0000185
reactant: MODEL1310110045#
notes: GENE_ASSOCIATION: (6515.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10421229,PMID:12750891,PMID:3170580,PMID:8504756,PMID:9230074 NOTES:NCD

metaM clpnd e
initial amount: NaN
notes: FORMULA: C22H33O2 CHARGE: -1 INCHI: InChI=1S/C22H34O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22(23)24/h3-4,6-7,9-10,12-13,15-16H,2,5,8,11,14,17-21H2,1H3,(H,23,24)/b4-3-,7-6-,10-9-,13-12-,16-15-
is: CHEBI:53488
initial concentration: 1.0
is: SBO:0000247
boundary condition: false
name: clupanodonic acid
is: HMDB06528
type: Species
has only substance units: false
constant: false

http://identifiers.org/biomodels.db/MODEL1310110045#_b150b974_720d_4e51_8494_e836344c687e
type: Species
is: O75610
name: LEFTY1
boundary condition: true
constant: false
has only substance units: false
initial concentration: NaN
is encoded by: hsa:10637
initial amount: NaN
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110045#_50ad8e05_5401_44f0_92a3_2df659d4a389
initial concentration: NaN
is: SBO:0000252
has only substance units: false
initial amount: NaN
is: Q6P1M0
is encoded by: hsa:10999
type: Species
boundary condition: true
constant: false
name: SLC27A4

metaR r2532
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:10049700,PMID:10574970,PMID:11389679,PMID:11557028,PMID:11564694,PMID:12824232,PMID:12930836,PMID:14574404,PMID:16288981,PMID:911815 NOTES:
reversible: true
product: MODEL1310110045#
is described by: ECO:0000000
fast: false
name: Major Facilitator(MFS) TCDB:2.A.1.44.1
kinetic law: MODEL1310110045#
type: Reaction
is: SBO:0000185
reactant: MODEL1310110045#

metaM occoa x
initial amount: NaN
is: CHEBI:57386
name: Octanoyl-CoA (n-C8:0CoA)
notes: FORMULA: C29H46N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00869 EHMN_ABBREVIATION: C01944
is: C01944
constant: false
initial concentration: 1.0
has only substance units: false
boundary condition: false
is: HMDB01070
is: SBO:0000247
type: Species

http://identifiers.org/biomodels.db/MODEL1310110045#_3aade212_6732_4ec6_a1ab_821a2247ba89
has only substance units: false
boundary condition: true
is: P49902
name: NT5C2
type: Species
constant: false
initial concentration: NaN
is encoded by: hsa:22978
initial amount: NaN
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110045#_0b6fceac_a448_4a93_a884_1c5f4a569ccb
has only substance units: false
name: ACHE
initial concentration: NaN
is encoded by: hsa:43
is: SBO:0000252
initial amount: NaN
boundary condition: true
constant: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110045#_3408b14c_d994_4866_8eb8_f718235644aa
initial amount: NaN
boundary condition: true
type: Species
has only substance units: false
initial concentration: NaN
constant: false
name: B3GNT2
is: SBO:0000252
is encoded by: hsa:10678

metaM succoa m
is: HMDB01022
is: SBO:0000247
constant: false
initial amount: NaN
has only substance units: false
name: Succinyl-CoA
initial concentration: 1.0
type: Species
notes: FORMULA: C25H35N7O19P3S CHARGE: -5 HEPATONET_1.0_ABBREVIATION: HC00093 EHMN_ABBREVIATION: C00091
is: CHEBI:57292
boundary condition: false

metaR S26Tg
is version of: http://identifiers.org/ec-code/2.4.99.1
is: SBO:0000176
notes: GENE_ASSOCIATION: (6480.1) or (6480.3) or (6480.2) SUBSYSTEM: N-glycan synthesis EC Number: 2.4.99.1 Confidence Level: 0 AUTHORS: PMID:8027041 NOTES:NCD
is described by: ECO:0000000
fast: false
type: Reaction
name: beta-galactoside alpha-2,6-sialyltransferase
modifier: MODEL1310110045#
kinetic law: MODEL1310110045#
reversible: false
product: MODEL1310110045#
reactant: MODEL1310110045#

http://identifiers.org/biomodels.db/MODEL1310110045#_826b517d_4bef_4e39_b1cf_8b3defc06e8e
is: SBO:0000252
boundary condition: true
is: P36969
type: Species
constant: false
is encoded by: hsa:2879
name: GPX4
initial amount: NaN
has only substance units: false
initial concentration: NaN

metaM cholcoads x
is: SBO:0000247
notes: FORMULA: C48H74N7O20P3S CHARGE: -4 INCHI: InChI=1S/C48H78N7O20P3S/c1-25(29-10-11-30-36-31(20-34(58)48(29,30)6)47(5)14-12-28(56)18-27(47)19-32(36)57)8-7-9-26(2)45(63)79-17-16-50-35(59)13-15-51-43(62)40(61)46(3,4)22-72-78(69,70)75-77(67,68)71-21-33-39(74-76(64,65)66)38(60)44(73-33)55-24-54-37-41(49)52-23-53-42(37)55/h9,23-25,27-34,36,38-40,44,56-58,60-61H,7-8,10-22H2,1-6H3,(H,50,59)(H,51,62)(H,67,68)(H,69,70)(H2,49,52,53)(H2,64,65,66)/t25-,27+,28-,29-,30+,31+,32-,33-,34+,36+,38-,39-,40+,44-,47+,48-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01466 EHMN_ABBREVIATION: C05460
boundary condition: false
initial concentration: 1.0
constant: false
is: HMDB06889
is: CHEBI:27505
has only substance units: false
type: Species
name: 3alpha,7alpha,12alpha-Trihydroxy-5beta-cholest-24-enoyl-CoA
initial amount: NaN

metaM lald D c
initial concentration: 1.0
initial amount: NaN
name: (R)-lactaldehyde
boundary condition: false
is: SBO:0000247
constant: false
type: Species
notes: FORMULA: C3H6O2 CHARGE: 0 INCHI: InChI=1S/C3H6O2/c1-3(5)2-4/h2-3,5H,1H3/t3-/m1/s1
is: CHEBI:17167
has only substance units: false
is: HMDB06458

http://identifiers.org/biomodels.db/MODEL1310110045#_a7f2abce_f1da_4f09_97bf_af30ee44761f
constant: false
type: Species
name: SYNJ1
is: SBO:0000252
boundary condition: true
is: O43426
initial concentration: NaN
initial amount: NaN
has only substance units: false
is encoded by: hsa:8867

http://identifiers.org/biomodels.db/MODEL1310110045#_2ffe440d_cdb2_45df_9aa5_34f55276a81a
type: Species
is encoded by: hsa:5298
name: PI4KB
boundary condition: true
is: SBO:0000252
initial amount: NaN
is: Q9UBF8
has only substance units: false
constant: false
initial concentration: NaN

metaM stcoa m
initial concentration: 1.0
is: SBO:0000247
notes: FORMULA: C39H66N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00338 EHMN_ABBREVIATION: C00412
is: CHEBI:57394
is: HMDB01114
has only substance units: false
is: C00412
name: Stearoyl-CoA (n-C18:0CoA)
initial amount: NaN
type: Species
boundary condition: false
constant: false

metaM cit m
notes: FORMULA: C6H5O7 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00153 EHMN_ABBREVIATION: C00158
has only substance units: false
boundary condition: false
type: Species
is: CHEBI:16947
name: Citrate
is: HMDB00094
constant: false
initial amount: NaN
initial concentration: 1.0
is: C00158
is: SBO:0000247

metaM xyl D l
constant: false
has only substance units: false
is: SBO:0000247
notes: FORMULA: C5H10O5 CHARGE: 0 INCHI: InChI=1S/C5H10O5/c6-1-3(8)5(10)4(9)2-7/h1,3-5,7-10H,2H2/t3-,4+,5+/m0/s1
is: CHEBI:15936
type: Species
initial concentration: 1.0
initial amount: NaN
boundary condition: false
name: aldehydo-D-xylose

http://identifiers.org/biomodels.db/MODEL1310110045#_f21d5e16_9a01_49a4_acbb_c35beb80bea0
is encoded by: hsa:6581
is: SBO:0000252
name: SLC22A3
has only substance units: false
is: Q5SYN6
initial concentration: NaN
constant: false
type: Species
boundary condition: true
initial amount: NaN

metaR NACHEX5ly
fast: false
is version of: http://identifiers.org/ec-code/3.2.1.52
name: beta-N-acetylhexosaminidase, lysosomal
product: MODEL1310110045#
type: Reaction
is described by: ECO:0000000
is: SBO:0000176
reactant: MODEL1310110045#
notes: GENE_ASSOCIATION: (3073.1) or (3073.1 and 3074.1) or (3074.1) SUBSYSTEM: Chondroitin sulfate degradation EC Number: 3.2.1.52 Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12706724,PMID:8993162 NOTES:NCD
modifier: MODEL1310110045#
kinetic law: MODEL1310110045#
reversible: false

metaR EX asn L LPAREN e RPAREN
kinetic law: MODEL1310110045#
reactant: MODEL1310110045#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for L-asparagine
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110045#_7e77c057_76e5_4dd2_9d9a_b2bae3a4bae5
initial amount: NaN
is: P16930
is encoded by: hsa:2184
has only substance units: false
boundary condition: true
name: FAH
type: Species
initial concentration: NaN
constant: false
is: SBO:0000252

metaR r1580
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reactant: MODEL1310110045#
is: SBO:0000185
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reversible: true
type: Reaction
product: MODEL1310110045#
fast: false
is described by: ECO:0000000
kinetic law: MODEL1310110045#

http://identifiers.org/biomodels.db/MODEL1310110045#_696f78a0_273d_4099_9217_6cf757203473
is: SBO:0000252
is encoded by: hsa:3098
has only substance units: false
initial concentration: NaN
is: B3KXY9
name: HK1
type: Species
boundary condition: true
constant: false
initial amount: NaN

metaM g3p c
is: CHEBI:58027
notes: FORMULA: C3H5O6P CHARGE: -2 INCHI: " HEPATONET_1.0_ABBREVIATION: HC00116
is: SBO:0000247
is: http://identifiers.org/pubchem.compound/3930
has only substance units: false
is: HMDB01112
type: Species
initial concentration: 1.0
is: C00661
initial amount: NaN
constant: false
boundary condition: false
name: Glyceraldehyde 3-phosphate

metaR r0630
type: Reaction
notes: GENE_ASSOCIATION: (52.1) or (53.1) or (54.1) or (51205.1) or (55.1) or (AI191472.1) or (248.1) or (249.1) or (250.1) or (251.1) SUBSYSTEM: Bile acid synthesis EC Number: 2.3.1.65 Confidence Level: 0 AUTHORS: PMID:10884298,PMID:12239217,PMID:12543708,PMID:15026425,PMID:3741411,PMID:6884990 NOTES:
product: MODEL1310110045#
reversible: true
name: Choloyl-CoA:glycine N-choloyltransferase Bile acid biosynthesis / Taurine and hypotaurine metabolism EC:2.3.1.65
modifier: MODEL1310110045#
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/3.1.3.2
reactant: MODEL1310110045#
is: SBO:0000176
fast: false
is version of: http://identifiers.org/ec-code/3.1.3.1
kinetic law: MODEL1310110045#

http://identifiers.org/biomodels.db/MODEL1310110045#_294fa71f_dcd2_431d_af5b_f6fbfa2b78a9
initial amount: NaN
boundary condition: true
is: SBO:0000252
constant: false
initial concentration: NaN
has only substance units: false
is encoded by: hsa:79053
type: Species
name: ALG8

http://identifiers.org/biomodels.db/MODEL1310110045#_947edb45_5ac0_4716_bcc0_fe7f0bce3031
type: Species
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:52
boundary condition: true
has only substance units: false
constant: false
name: ACP1
is: Q59EH3
initial amount: NaN

metaR r1581
product: MODEL1310110045#
fast: false
kinetic law: MODEL1310110045#
reactant: MODEL1310110045#
reversible: true
type: Reaction
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is: SBO:0000185
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1

http://identifiers.org/biomodels.db/MODEL1310110045#_6d0654fd_02d8_4a18_9752_1f17c3f87171
name: SLC19A3
boundary condition: true
type: Species
is: SBO:0000252
constant: false
is: Q9BZV2
is encoded by: hsa:80704
initial amount: NaN
initial concentration: NaN
has only substance units: false

metaM zymst r
type: Species
initial amount: NaN
notes: FORMULA: C27H44O CHARGE: 0 INCHI: InChI=1S/C27H44O/c1-18(2)7-6-8-19(3)23-11-12-24-22-10-9-20-17-21(28)13-15-26(20,4)25(22)14-16-27(23,24)5/h7,19-21,23-24,28H,6,8-17H2,1-5H3/t19-,20+,21+,23-,24+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01451 EHMN_ABBREVIATION: C05437
name: zymosterol
boundary condition: false
is: SBO:0000247
is: HMDB06271
initial concentration: 1.0
has only substance units: false
constant: false
is: CHEBI:18252

metaM HC02208 e
name: prostaglandin-d1
type: Species
constant: false
notes: FORMULA: C20H33O5 CHARGE: -1 INCHI: InChI=1S/C20H34O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h12-13,15-18,21-22H,2-11,14H2,1H3,(H,24,25)/b13-12+/t15-,16+,17+,18-/m0/s1
has only substance units: false
initial amount: NaN
is: SBO:0000247
boundary condition: false
is: CHEBI:27696
initial concentration: 1.0

metaR r0027
product: MODEL1310110045#
type: Reaction
is described by: ECO:0000000
modifier: MODEL1310110045#
fast: false
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.14.13.39
kinetic law: MODEL1310110045#
reactant: MODEL1310110045#
reversible: true
name: NADPH:CoA-glutathione oxidoreductase EC:1.8.1.9
notes: GENE_ASSOCIATION: (285973.1) or (D29675.1) or (4842.1) or (NOS2A.1) or (4846.1) SUBSYSTEM: Methionine and cysteine metabolism EC Number: 1.8.1.9 Confidence Level: 0 AUTHORS: PMID:18042542 NOTES:

metaR EX Rtotal3 LPAREN e RPAREN
kinetic law: MODEL1310110045#
reactant: MODEL1310110045#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: R total 3 position exchange
type: Reaction

metaR BTNt4i
product: MODEL1310110045#
type: Reaction
is: SBO:0000185
name: Biotin uptake (antiport)
reactant: MODEL1310110045#
notes: GENE_ASSOCIATION: (80704.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14770311,PMID:15623830 NOTES:IT
kinetic law: MODEL1310110045#
is described by: ECO:0000269
reversible: false
fast: false
modifier: MODEL1310110045#

metaR EX CE5787 LPAREN e RPAREN
kinetic law: MODEL1310110045#
reactant: MODEL1310110045#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: kinetensin 1-3 exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110045#_75bddd86_462f_4659_9a28_ea1e4ae86ac6
boundary condition: true
has only substance units: false
is: SBO:0000252
is: B4DJQ3
initial amount: NaN
initial concentration: NaN
constant: false
is encoded by: hsa:6472
type: Species
name: SHMT2

http://identifiers.org/biomodels.db/MODEL1310110045#_714e09f3_885d_4d05_a194_39ef5bbf7cc2
name: _AI656480_1_m
initial concentration: NaN
is: SBO:0000252
type: Species
initial amount: NaN
boundary condition: true
constant: false
has only substance units: false
is encoded by: hsa:AI656480

metaM atp e
is: SBO:0000247
is: HMDB00538
constant: false
is: CHEBI:57299
type: Species
has only substance units: false
name: ATP(4-)
is: C00002
boundary condition: false
initial amount: NaN
initial concentration: 1.0

metaM ile L c
type: Species
initial concentration: 1.0
notes: FORMULA: C6H13NO2 CHARGE: 0 INCHI: InChI=1S/C6H13NO2/c1-3-4(2)5(7)6(8)9/h4-5H,3,7H2,1-2H3,(H,8,9)/t4-,5-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00334 EHMN_ABBREVIATION: C00407
constant: false
has only substance units: false
is: SBO:0000247
is: CHEBI:17191
is: HMDB00172
boundary condition: false
initial amount: NaN
name: L-isoleucine

http://identifiers.org/biomodels.db/MODEL1310110045#_38f5a9df_bdbc_4174_b2ba_975466598f47
initial concentration: NaN
type: Species
is: SBO:0000252
boundary condition: true
is encoded by: hsa:AI469183
initial amount: NaN
constant: false
name: _AI469183_1_x
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110045#_19777cc9_f1c6_48ff_9e6b_ba82c1f3ecb9
name: HAO2
has only substance units: false
initial amount: NaN
is: Q9NYQ3
is encoded by: hsa:51179
boundary condition: true
initial concentration: NaN
type: Species
is: SBO:0000252
constant: false

metaR EX dopasf LPAREN e RPAREN
kinetic law: MODEL1310110045#
reactant: MODEL1310110045#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Dopamine 3-O-sulfate exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110045#_bc790536_b551_463d_884a_af7297dbfc98
type: Species
is encoded by: hsa:55811
boundary condition: true
has only substance units: false
constant: false
initial amount: NaN
is: F5GWS5
name: ADCY10
is: SBO:0000252
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110045#_5093e880_1bb7_4679_8ab6_eeb888c855b4
constant: false
initial amount: NaN
is encoded by: hsa:9963
boundary condition: true
has only substance units: false
is: Q9UHI7
type: Species
initial concentration: NaN
name: SLC23A1
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110045#_478ba438_0a1d_458c_858f_1380d7126a31
is encoded by: hsa:57194
constant: false
name: ATP10A
is: O60312
has only substance units: false
is: SBO:0000252
initial concentration: NaN
type: Species
initial amount: NaN
boundary condition: true

metaM 6dhf l
is: HMDB06563
boundary condition: false
initial concentration: 1.0
constant: false
initial amount: NaN
name: hexaglutamyl folate (DHF)
notes: FORMULA: C44H49N12O21 CHARGE: -7 INCHI: InChI=1/C44H54N12O21/c45-21(36(66)67)5-10-26(57)43(15-30(61)62,27(58)11-6-22(46)37(68)69)44(28(59)12-7-23(47)38(70)71,41(76)77-31(63)14-9-25(49)40(74)75)56(29(60)13-8-24(48)39(72)73)35(65)18-1-3-19(4-2-18)51-16-20-17-52-33-32(53-20)34(64)55-42(50)54-33/h1-4,17,21-25,51H,5-16,45-49H2,(H,61,62)(H,66,67)(H,68,69)(H,70,71)(H,72,73)(H,74,75)(H3,50,52,54,55,64)/t21-,22-,23-,24-,25-,44+/m0/s1
type: Species
is: SBO:0000247
has only substance units: false

metaR EX thymd LPAREN e RPAREN
kinetic law: MODEL1310110045#
reactant: MODEL1310110045#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Thymidine exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110045#_0bc0771a_aee3_4ee8_a0ac_b3067da119cd
name: ACOT2
is encoded by: hsa:10965
is: P49753
type: Species
has only substance units: false
initial amount: NaN
is: SBO:0000252
constant: false
boundary condition: true
initial concentration: NaN

metaR FAOXC184m
kinetic law: MODEL1310110045#
product: MODEL1310110045#
reactant: MODEL1310110045#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: isomerization of (C18:4)m
type: Reaction

metaR r1583
is: SBO:0000185
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
fast: false
kinetic law: MODEL1310110045#
product: MODEL1310110045#
reversible: true
type: Reaction
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reactant: MODEL1310110045#

metaM 6dhf m
is: HMDB06563
constant: false
initial amount: NaN
boundary condition: false
initial concentration: 1.0
name: hexaglutamyl folate (DHF)
type: Species
is: SBO:0000247
has only substance units: false
notes: FORMULA: C44H49N12O21 CHARGE: -7 INCHI: InChI=1/C44H54N12O21/c45-21(36(66)67)5-10-26(57)43(15-30(61)62,27(58)11-6-22(46)37(68)69)44(28(59)12-7-23(47)38(70)71,41(76)77-31(63)14-9-25(49)40(74)75)56(29(60)13-8-24(48)39(72)73)35(65)18-1-3-19(4-2-18)51-16-20-17-52-33-32(53-20)34(64)55-42(50)54-33/h1-4,17,21-25,51H,5-16,45-49H2,(H,61,62)(H,66,67)(H,68,69)(H,70,71)(H,72,73)(H,74,75)(H3,50,52,54,55,64)/t21-,22-,23-,24-,25-,44+/m0/s1

http://identifiers.org/biomodels.db/MODEL1310110045#_79bd913d_4799_449e_a5ba_daafa36313f1
has only substance units: false
constant: false
is: P11310
initial concentration: NaN
name: ACADM
boundary condition: true
is encoded by: hsa:34
type: Species
is: SBO:0000252
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110045#_b8f1cbec_3884_4e34_92c7_da07c2b051d0
initial concentration: NaN
constant: false
name: ACSL1
is: SBO:0000252
has only substance units: false
is encoded by: hsa:2180
boundary condition: true
initial amount: NaN
is: P33121
type: Species

metaM ile L e
type: Species
constant: false
is: SBO:0000247
initial concentration: 1.0
is: CHEBI:17191
initial amount: NaN
notes: FORMULA: C6H13NO2 CHARGE: 0 INCHI: InChI=1S/C6H13NO2/c1-3-4(2)5(7)6(8)9/h4-5H,3,7H2,1-2H3,(H,8,9)/t4-,5-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00334 EHMN_ABBREVIATION: C00407
is: HMDB00172
has only substance units: false
boundary condition: false
name: L-isoleucine

metaR r0634
is version of: http://identifiers.org/ec-code/3.1.4.1
is described by: ECO:0000000
name: Octanoyl-CoA:acetyl-CoA C-acyltransferase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:2.3.1.16
is: SBO:0000176
reversible: true
type: Reaction
product: MODEL1310110045#
notes: GENE_ASSOCIATION: (AI926493.1) or (5167.1) or (5169.1) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.16 Confidence Level: 0 AUTHORS: PMID:1121274,PMID:1679347,PMID:3194209,PMID:6378901,PMID:8241273 NOTES:
reactant: MODEL1310110045#
modifier: MODEL1310110045#
fast: false
kinetic law: MODEL1310110045#

metaM atp c
is: CHEBI:30616
has only substance units: false
boundary condition: false
initial amount: NaN
type: Species
name: ATP(4-)
is: HMDB00538
is: SBO:0000247
initial concentration: 1.0
constant: false
is: C00002

http://identifiers.org/biomodels.db/MODEL1310110045#_129c9a77_bc69_4dff_943e_8f9e04043025
boundary condition: true
is: SBO:0000252
has only substance units: false
initial amount: NaN
is encoded by: hsa:6487
constant: false
initial concentration: NaN
name: ST3GAL3
type: Species

metaR NCNt
reactant: MODEL1310110045#
is: SBO:0000185
kinetic law: MODEL1310110045#
name: Na+/Ca2+-NH4+ exchange
notes: GENE_ASSOCIATION: (9187.1) or (25769.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10484410,PMID:10662833,PMID:11294880,PMID:12379639,PMID:14770312,PMID:9478004 NOTES:NCD
product: MODEL1310110045#
modifier: MODEL1310110045#
is described by: ECO:0000269
reversible: true
fast: false
type: Reaction

metaR ADMDC
name: adenosylmethionine decarboxylase
product: MODEL1310110045#
type: Reaction
kinetic law: MODEL1310110045#
fast: false
modifier: MODEL1310110045#
reactant: MODEL1310110045#
is described by: ECO:0000269
reversible: false
is: SBO:0000176
is version of: http://identifiers.org/ec-code/4.1.1.50
notes: GENE_ASSOCIATION: (262.1) SUBSYSTEM: Arginine and Proline Metabolism EC Number: 4.1.1.50 Confidence Level: 4 AUTHORS: PMID:2460457 NOTES:

metaM g3m8masn r
type: Species
has only substance units: false
name: (alpha-D-Glucosyl)3-(alpha-D-mannosyl)8-beta-D-mannosyl-diacetylchitobiosyl-L-asparagine (protein)
is: SBO:0000247
boundary condition: false
notes: FORMULA: C88H147N2O70X CHARGE: 0
initial concentration: 1.0
initial amount: NaN
constant: false
is: C05873

http://identifiers.org/biomodels.db/MODEL1310110045#_d80b8ad0_804d_42b0_ab48_279e0b1a29fc
has only substance units: false
is encoded by: hsa:570
name: BAAT
boundary condition: true
is: Q14032
constant: false
initial amount: NaN
is: SBO:0000252
initial concentration: NaN
type: Species

metaM cdpdag hs c
notes: FORMULA: C12H17N3O11P2FULLRCO2FULLR2CO2 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC02078
is: SBO:0000247
initial concentration: 1.0
type: Species
has only substance units: false
boundary condition: false
constant: false
is: CHEBI:58332
initial amount: NaN
name: CDP-diacylglycerol(2-)

http://identifiers.org/biomodels.db/MODEL1310110045#_fc78264d_d44a_483b_b001_354ed0d036b5
is: Q9P2T1
type: Species
is: SBO:0000252
initial amount: NaN
boundary condition: true
has only substance units: false
initial concentration: NaN
name: GMPR2
constant: false
is encoded by: hsa:51292

metaM dnad c
constant: false
initial amount: NaN
name: Deamino-NAD+
initial concentration: 1.0
type: Species
is: HMDB01179
is: CHEBI:18304
is: SBO:0000247
notes: FORMULA: C21H24N6O15P2 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00564 EHMN_ABBREVIATION: C00857
is: C00857
boundary condition: false
has only substance units: false

metaR r1584
kinetic law: MODEL1310110045#
fast: false
reversible: true
reactant: MODEL1310110045#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is: SBO:0000185
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
product: MODEL1310110045#
is described by: ECO:0000000

metaR P45027A14m
type: Reaction
product: MODEL1310110045#
kinetic law: MODEL1310110045#
is version of: http://identifiers.org/ec-code/1.14.13.15
reactant: MODEL1310110045#
name: 5-beta-cytochrome P450, family 27, subfamily A, polypeptide 1
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (1593.1) SUBSYSTEM: Bile acid synthesis EC Number: 1.14.13.15 Confidence Level: 4 AUTHORS: NOTES:from uniprot NJ
modifier: MODEL1310110045#
fast: false
reversible: false
is: SBO:0000176

metaR RE3567C
reversible: true
type: Reaction
reactant: MODEL1310110045#
is described by: ECO:0000000
product: MODEL1310110045#
is: SBO:0000176
fast: false
name: RE3567
notes: GENE_ASSOCIATION: SUBSYSTEM: Eicosanoid metabolism EC Number: 5.3.3.9 Confidence Level: 0 AUTHORS: PMID:234423 NOTES:
kinetic law: MODEL1310110045#

metaM HC01412 m
is: SBO:0000247
has only substance units: false
boundary condition: false
notes: FORMULA: C35H56N7O17P3S CHARGE: -4 INCHI: InChI=1S/C35H60N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-26(44)63-19-18-37-25(43)16-17-38-33(47)30(46)35(2,3)21-56-62(53,54)59-61(51,52)55-20-24-29(58-60(48,49)50)28(45)34(57-24)42-23-41-27-31(36)39-22-40-32(27)42/h14-15,22-24,28-30,34,45-46H,4-13,16-21H2,1-3H3,(H,37,43)(H,38,47)(H,51,52)(H,53,54)(H2,36,39,40)(H2,48,49,50)/p-4/b15-14+/t24-,28-,29-,30+,34-/m1/s1 EHMN_ABBREVIATION: C05273
is: CHEBI:61405
initial concentration: 1.0
type: Species
name: trans-tetradec-2-enoyl-CoA(4-)
constant: false
initial amount: NaN

metaR r0633
name: trans-Oct-2-enoyl-CoA reductase Fatty acid elongation in mitochondria EC:1.3.1.38
modifier: MODEL1310110045#
product: MODEL1310110045#
is described by: ECO:0000000
reactant: MODEL1310110045#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.7.7.3
fast: false
kinetic law: MODEL1310110045#
notes: GENE_ASSOCIATION: (80347.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.1.38 Confidence Level: 0 AUTHORS: PMID:12654921 NOTES:
reversible: true
type: Reaction

metaR P4508B11r
name: sterol 12-alpha-hydroxylase
kinetic law: MODEL1310110045#
is: SBO:0000176
reactant: MODEL1310110045#
is version of: http://identifiers.org/ec-code/1.14.13.95
is described by: ECO:0000269
product: MODEL1310110045#
notes: GENE_ASSOCIATION: (1582.1) SUBSYSTEM: Bile acid synthesis EC Number: Confidence Level: 4 AUTHORS: NOTES:NJ - added, substrates by analogy to other xol hydroxylase reactions (NADH and NADPH can both be used)
reversible: false
fast: false
modifier: MODEL1310110045#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110045#_9e0e9135_fb73_470d_8a06_f30cbd35389d
boundary condition: true
name: TUSC3
is encoded by: hsa:7991
type: Species
is: SBO:0000252
initial concentration: NaN
has only substance units: false
constant: false
initial amount: NaN

metaR HISCAT1
kinetic law: MODEL1310110045#
product: MODEL1310110045#
reactant: MODEL1310110045#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: Transport of L-Histidine by y+ transporter
type: Reaction

metaR ALDD2y
is version of: http://identifiers.org/ec-code/1.2.1.36
is version of: http://identifiers.org/ec-code/1.2.1.3
is: SBO:0000176
type: Reaction
product: MODEL1310110045#
is described by: ECO:0000000
reactant: MODEL1310110045#
reversible: false
is version of: http://identifiers.org/ec-code/1.2.1.5
modifier: MODEL1310110045#
notes: GENE_ASSOCIATION: (223.1) or (221.1) or (218.1) or (8854.1) or (8854.3) or (222.1) or (8854.2) or (224.1) SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: 1.2.1.4 Confidence Level: 0 AUTHORS: PMID:12616643 NOTES:See also ALDH1 (1.2.1.3); r0177
name: aldehyde dehydrogenase (acetaldehyde, NADP)
fast: false
kinetic law: MODEL1310110045#

metaR r1585
reversible: true
kinetic law: MODEL1310110045#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
fast: false
is described by: ECO:0000000
reactant: MODEL1310110045#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is: SBO:0000185
product: MODEL1310110045#

http://identifiers.org/biomodels.db/MODEL1310110045#_a60a0ceb_f194_4d6d_98bf_653798af71c1
is: C9JZ62
type: Species
initial amount: NaN
name: TMEM91
has only substance units: false
constant: false
boundary condition: true
is encoded by: hsa:641649
is: SBO:0000252
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110045#_a37c996c_e0d2_4085_b0d2_cb652ec1a155
constant: false
has only substance units: false
boundary condition: true
is: SBO:0000252
name: DGKH
is: A8K0I1
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:160851
type: Species

metaM dhf c
notes: FORMULA: C19H19N7O6 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00340 EHMN_ABBREVIATION: C00415
is: HMDB01056
initial concentration: 1.0
is: SBO:0000247
has only substance units: false
is: CHEBI:57451
type: Species
name: 7,8-Dihydrofolate
is: C00415
boundary condition: false
constant: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110045#_670d75b8_a7eb_4907_8eec_77c11e7534fc
has part: Q53YB7
is encoded by: hsa:1351
has part: Q6YFQ2
is encoded by: hsa:1327
is encoded by: hsa:9167
is encoded by: hsa:1345
is encoded by: hsa:1339
is encoded by: hsa:1329
has part: Q02221
initial concentration: NaN
has part: Q7GXY8
has part: Q53XN1
is: SBO:0000297
is encoded by: hsa:1340
has part: H0UI06
is encoded by: hsa:4514
has part: P15954
boundary condition: true
is encoded by: hsa:170712
has part: Q96KJ9
is encoded by: hsa:9377
is encoded by: hsa:1347
is encoded by: hsa:1346
has part: Q8TF08
has part: P13073
has part: P09669
has part: P00414
has part: Q7GXZ8
is encoded by: hsa:84701
has part: P20674
name: COX6B2:COX4I1:COX5B:COX6A1:COX6A2:COX6B1:COX6C:COX7A1:COX7A2:COX7B:COX7C:COX8A:COX7B2:COX8C:COX1:COX2:COX3:COX4I2:COX7A2L:COX5A
has part: P14854
has only substance units: false
has part: P24311
has part: Q6FGA0
is encoded by: hsa:125965
has part: P12074
has part: P24310
is encoded by: hsa:1349
type: Species
has part: Q7Z4L0
is encoded by: hsa:1350
constant: false
is encoded by: hsa:341947
is encoded by: hsa:1337
initial amount: NaN
is encoded by: hsa:4513
is encoded by: hsa:4512

metaR DCSPTN1CPT2
kinetic law: MODEL1310110045#
is described by: ECO:0000000
fast: false
reversible: false
type: Reaction
product: MODEL1310110045#
name: carnitine transferase
notes: GENE_ASSOCIATION: (1376.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: NOTES:NJ
is version of: http://identifiers.org/ec-code/2.3.1.21
reactant: MODEL1310110045#
modifier: MODEL1310110045#
is: SBO:0000176

metaR EX q10 LPAREN e RPAREN
kinetic law: MODEL1310110045#
reactant: MODEL1310110045#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for ubiquinone
type: Reaction

metaR DCSPTN1CPT1
type: Reaction
reversible: false
notes: GENE_ASSOCIATION: (1375.1) or (1375.3) or (1375.4) or (126129.1) or (1374.1) or (1375.2) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.21 Confidence Level: 4 AUTHORS: NOTES:NJ
product: MODEL1310110045#
is described by: ECO:0000269
kinetic law: MODEL1310110045#
reactant: MODEL1310110045#
fast: false
modifier: MODEL1310110045#
is: SBO:0000176
name: carnitine O-palmitoyltransferase
is version of: http://identifiers.org/ec-code/2.3.1.21

http://identifiers.org/biomodels.db/MODEL1310110045#_9635cf24_e831_4e06_821f_57f5010a34de
is encoded by: hsa:5295
type: Species
is: SBO:0000297
initial amount: NaN
has part: E7EX19
name: PIK3CD:PIK3R1
constant: false
has only substance units: false
initial concentration: NaN
boundary condition: true

metaR r1586
fast: false
reversible: true
is: SBO:0000185
reactant: MODEL1310110045#
type: Reaction
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is described by: ECO:0000000
product: MODEL1310110045#
kinetic law: MODEL1310110045#

metaR EX ile L LPAREN e RPAREN
kinetic law: MODEL1310110045#
reactant: MODEL1310110045#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: L-Isoleucine exchange
type: Reaction

metaR ALDD2x
product: MODEL1310110045#
fast: false
is version of: http://identifiers.org/ec-code/1.2.1.5
kinetic law: MODEL1310110045#
name: aldehyde dehydrogenase (acetaldehyde, NAD)
modifier: MODEL1310110045#
reactant: MODEL1310110045#
type: Reaction
is: SBO:0000176
reversible: false
is version of: http://identifiers.org/ec-code/1.2.1.36
is version of: http://identifiers.org/ec-code/1.2.1.3
notes: GENE_ASSOCIATION: (218.1) or (501.1) or (8854.2) or (224.1) or (222.1) or (8854.1) or (221.1) or (216.1) or (8854.3) or (223.1) or (220.1) SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: 1.2.1.3 Confidence Level: 0 AUTHORS: PMID:12616643 NOTES:Only acetaldehyde considered for now. See also 1.2.1.4. Wide specificity, including oxidation of D-glucuronolactone to D-glucarate. Formerly EC 1.1.1.70; r0176
is described by: ECO:0000000

metaR RE0827E
type: Reaction
kinetic law: MODEL1310110045#
fast: false
name: RE0827
is version of: http://identifiers.org/ec-code/1.4.3.22
modifier: MODEL1310110045#
reactant: MODEL1310110045#
is: SBO:0000176
notes: GENE_ASSOCIATION: (26.1) SUBSYSTEM: Urea cycle EC Number: 1.4.3.6 Confidence Level: 0 AUTHORS: PMID:10047787,PMID:7040832 NOTES:
reversible: false
is described by: ECO:0000000
product: MODEL1310110045#

http://identifiers.org/biomodels.db/MODEL1310110045#_bfa4ad0e_c8f5_49f4_b37a_4a33caff1a94
has part: P15531
is: SBO:0000297
has only substance units: false
type: Species
boundary condition: true
is encoded by: hsa:4831
name: NME1:NME2
initial amount: NaN
constant: false
is encoded by: hsa:4830
initial concentration: NaN
has part: P22392

http://identifiers.org/biomodels.db/MODEL1310110045#_27466ccc_f986_4bc5_af07_5386c51e6cea
constant: false
type: Species
is: SBO:0000252
boundary condition: true
has only substance units: false
initial concentration: NaN
is encoded by: hsa:275
is: P48728
initial amount: NaN
name: AMT

metaM lnlccrn m
boundary condition: false
is: HMDB06469
type: Species
initial concentration: 1.0
notes: FORMULA: C25H45NO4 CHARGE: 0 INCHI: InChI=1/C25H45NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-25(29)30-23(21-24(27)28)22-26(2,3)4/h9-10,12-13,23H,5-8,11,14-22H2,1-4H3/b10-9-,13-12-/t23-/m1/s1
has only substance units: false
constant: false
name: Linoleyl carnitine
is: SBO:0000247
initial amount: NaN

metaR NACHEXA14ly
product: MODEL1310110045#
reversible: false
is described by: ECO:0000000
kinetic law: MODEL1310110045#
notes: GENE_ASSOCIATION: (3073.1) or (3073.1 and 3074.1) SUBSYSTEM: Keratan sulfate degradation EC Number: Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12706724,PMID:8993162 NOTES:Note that this reaction is specific to beta-N-acetylhexosaminidase A and cannot be catalyzed by beta-N-acetylhexosaminidase B (or presumably beta-N-acetylhexosaminidase S). This is also a lumped reaction, representing the cleavage of GalNAc4S or GalNAc6S and N-acetylgalactosamine 4-sulfatase or 6-sulfatase. NCD
type: Reaction
is version of: http://identifiers.org/ec-code/3.2.1.52
reactant: MODEL1310110045#
name: beta-N-acetylhexosaminidase A, lysosomal
modifier: MODEL1310110045#
fast: false
is: SBO:0000176

metaR CHOLK
notes: GENE_ASSOCIATION: (1120.2) or (1119.1) or (1120.1) or (1119.2) SUBSYSTEM: Glycerophospholipid metabolism EC Number: Confidence Level: 4 AUTHORS: NOTES:
type: Reaction
is: SBO:0000176
fast: false
is described by: ECO:0000269
reactant: MODEL1310110045#
is version of: http://identifiers.org/ec-code/2.7.1.32
reversible: false
name: Choline kinase
kinetic law: MODEL1310110045#
modifier: MODEL1310110045#
product: MODEL1310110045#

metaM pep c
type: Species
has only substance units: false
name: Phosphoenolpyruvate
constant: false
initial concentration: 1.0
notes: FORMULA: C3H2O6P CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00076 EHMN_ABBREVIATION: C00074
initial amount: NaN
is: C00074
boundary condition: false
is: CHEBI:18021
is: SBO:0000247
is: HMDB00263

http://identifiers.org/biomodels.db/MODEL1310110045#_4f497279_491e_401d_8b36_17ad70f86a33
type: Species
has only substance units: false
boundary condition: true
initial concentration: NaN
is encoded by: hsa:AI539321
constant: false
name: _AI539321_1_c
is: SBO:0000252
initial amount: NaN

metaM adp e
constant: false
is: SBO:0000247
is: HMDB01341
initial concentration: 1.0
initial amount: NaN
notes: FORMULA: C10H12N5O10P2 CHARGE: -3 INCHI: InChI=1S/C10H15N5O10P2/c11-8-5-9(13-2-12-8)15(3-14-5)10-7(17)6(16)4(24-10)1-23-27(21,22)25-26(18,19)20/h2-4,6-7,10,16-17H,1H2,(H,21,22)(H2,11,12,13)(H2,18,19,20)/p-3/t4-,6-,7-,10-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00018 EHMN_ABBREVIATION: C00008
name: ADP(3-)
type: Species
has only substance units: false
boundary condition: false
is: CHEBI:456216

metaR LEUKTRD4t
kinetic law: MODEL1310110045#
fast: false
product: MODEL1310110045#
reactant: MODEL1310110045#
is described by: ECO:0000269
type: Reaction
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10358072,PMID:12507753,PMID:9334206 NOTES:
reversible: true
name: leukotriene D4 transport

metaM digalsgalside hs c
initial concentration: 1.0
constant: false
initial amount: NaN
name: Digalactosylceramidesulfate
is: C06127
is: http://identifiers.org/pubchem.compound/8384
is: SBO:0000247
notes: FORMULA: C30H55NO15SFULLRCO CHARGE: -1 EHMN_ABBREVIATION: C06127
boundary condition: false
has only substance units: false
type: Species

metaR r1587
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reversible: true
product: MODEL1310110045#
kinetic law: MODEL1310110045#
type: Reaction
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is described by: ECO:0000000
is: SBO:0000185
reactant: MODEL1310110045#

metaM asp D c
initial amount: NaN
is: HMDB06483
boundary condition: false
initial concentration: 1.0
type: Species
has only substance units: false
constant: false
name: D-aspartate(1-)
notes: FORMULA: C4H6NO4 CHARGE: -1 INCHI: InChI=1S/C4H7NO4/c5-2(4(8)9)1-3(6)7/h2H,1,5H2,(H,6,7)(H,8,9)/p-1/t2-/m1/s1
is: SBO:0000247
is: CHEBI:29990

http://identifiers.org/biomodels.db/MODEL1310110045#_47e85c80_e1c0_440d_a024_d69e2d325af0
initial amount: NaN
has only substance units: false
constant: false
is: P27987
boundary condition: true
is: SBO:0000252
type: Species
is encoded by: hsa:3707
initial concentration: NaN
name: ITPKB

metaM udp e
has only substance units: false
boundary condition: false
constant: false
is: HMDB00295
type: Species
name: UDP(3-)
initial amount: NaN
is: SBO:0000247
is: CHEBI:58223
initial concentration: 1.0
notes: FORMULA: C9H11N2O12P2 CHARGE: -3 INCHI: InChI=1S/C9H14N2O12P2/c12-5-1-2-11(9(15)10-5)8-7(14)6(13)4(22-8)3-21-25(19,20)23-24(16,17)18/h1-2,4,6-8,13-14H,3H2,(H,19,20)(H,10,12,15)(H2,16,17,18)/p-3/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00025 EHMN_ABBREVIATION: C00015

metaR EX dgtp LPAREN e RPAREN
kinetic law: MODEL1310110045#
reactant: MODEL1310110045#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of dGTP
type: Reaction

metaR r0638
is described by: ECO:0000000
kinetic law: MODEL1310110045#
is version of: http://identifiers.org/ec-code/2.8.1.2
reversible: true
is: SBO:0000176
notes: GENE_ASSOCIATION: (4357.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.1.38 Confidence Level: 0 AUTHORS: PMID:12654921 NOTES:
fast: false
type: Reaction
modifier: MODEL1310110045#
product: MODEL1310110045#
name: trans-Dodec-2-enoyl-CoA reductase Fatty acid elongation in mitochondria EC:1.3.1.38
reactant: MODEL1310110045#

metaR DCK1n
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/2.7.1.74
reversible: true
product: MODEL1310110045#
fast: false
is: SBO:0000176
type: Reaction
reactant: MODEL1310110045#
modifier: MODEL1310110045#
name: Deoxycytidine kinase, nuclear (ATP)
notes: GENE_ASSOCIATION: (1633.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.1.74 Confidence Level: 4 AUTHORS: PMID:10387103,PMID:12535661,PMID:9342341 NOTES:IT (2.7.1.74)
kinetic law: MODEL1310110045#

metaR CRVNCtr
is: SBO:0000185
reactant: MODEL1310110045#
fast: false
type: Reaction
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11788354,PMID:12864740 NOTES:NJ
name: fatty acid transport via diffusion
product: MODEL1310110045#
reversible: true
kinetic law: MODEL1310110045#

metaR EX dpcoa LPAREN e RPAREN
kinetic law: MODEL1310110045#
reactant: MODEL1310110045#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for dpcoa
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110045#_4a0b207c_e78a_45cb_801e_7aeb048edcb6
type: Species
name: ALDH1A2
initial concentration: NaN
is: B4DZR2
boundary condition: true
initial amount: NaN
has only substance units: false
is encoded by: hsa:8854
is: SBO:0000252
constant: false

metaR r1588
kinetic law: MODEL1310110045#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is: SBO:0000185
type: Reaction
product: MODEL1310110045#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reactant: MODEL1310110045#
fast: false
is described by: ECO:0000000
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110045#_4be82684_404c_4a2e_9b78_de7933024cef
name: NME1
constant: false
is encoded by: hsa:4830
is: SBO:0000252
type: Species
boundary condition: true
has only substance units: false
initial amount: NaN
initial concentration: NaN

metaR HMGCOAtm
kinetic law: MODEL1310110045#
is: SBO:0000185
type: Reaction
fast: false
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: PMID:14713247 NOTES:NCD
reactant: MODEL1310110045#
product: MODEL1310110045#
name: Hydroxymethylglutaryl-CoA reversible mitochondrial transport
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110045#_02bf553b_d1fe_48e0_84e3_f2091b969d96
is: Q92911
name: SLC5A5
boundary condition: true
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:6528
initial concentration: NaN
type: Species
constant: false
has only substance units: false

metaM adp c
initial concentration: 1.0
type: Species
has only substance units: false
boundary condition: false
is: C00008
initial amount: NaN
name: ADP
constant: false
is: HMDB01341
is: SBO:0000247
is: http://identifiers.org/pubchem.compound/3310
is: CHEBI:16761

http://identifiers.org/biomodels.db/MODEL1310110045#_8a3e0da1_138f_49e0_b4eb_6c62d0e6b27a
constant: false
name: PIK3CA
initial amount: NaN
initial concentration: NaN
is: P42336
type: Species
has only substance units: false
is: SBO:0000252
is encoded by: hsa:5290
boundary condition: true

metaR r1589
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
kinetic law: MODEL1310110045#
is: SBO:0000185
is described by: ECO:0000000
reversible: true
product: MODEL1310110045#
reactant: MODEL1310110045#
fast: false
type: Reaction

metaR ICDHxm
type: Reaction
name: Isocitrate dehydrogenase (NAD+)
fast: false
notes: GENE_ASSOCIATION: (3421.2 and 3420.3 and 3419.1) or (3420.1 and 3421.1 and 3419.1) or (3420.1 and 3421.1 and 3419.1) or (3420.3 and 3421.1 and 3419.1) or (3421.1 and 3419.1 and 3420.2) or (3421.2 and 3419.1 and 3420.2) SUBSYSTEM: Citric acid cycle EC Number: 1.1.1.41 Confidence Level: 0 AUTHORS: PMID:10601238,PMID:14555658 NOTES:The reaction may be reversible. Strathern shows the reactions as irreversible. IF. Biochemical, Genetic
is version of: http://identifiers.org/ec-code/1.1.1.41
is: SBO:0000176
reactant: MODEL1310110045#
modifier: MODEL1310110045#
reversible: false
product: MODEL1310110045#
kinetic law: MODEL1310110045#
is described by: ECO:0000134

metaR G14T15g
reversible: false
kinetic law: MODEL1310110045#
is version of: http://identifiers.org/ec-code/2.4.1.22
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/2.4.1.38
name: beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase, Golgi
notes: GENE_ASSOCIATION: (8703.1) or (2683.1) or (8704.2) or (8704.1) or (9334.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.38 Confidence Level: 4 AUTHORS: PMID:12512857,PMID:1903938,PMID:3094506,PMID:3144273,PMID:9405390,PMID:9435216 NOTES:Keratan sulfate I biosynthesis NCD
modifier: MODEL1310110045#
product: MODEL1310110045#
fast: false
is: SBO:0000176
type: Reaction
is version of: http://identifiers.org/ec-code/2.4.1.90
reactant: MODEL1310110045#

http://identifiers.org/biomodels.db/MODEL1310110045#_fe06e390_9669_44a5_86b8_2416f0010df6
initial concentration: NaN
has only substance units: false
is: SBO:0000252
boundary condition: true
is encoded by: hsa:LOC647190
name: _LOC647190_1_c
constant: false
type: Species
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110045#_8ee96348_3099_4866_9389_13cc07819700
constant: false
is encoded by: hsa:10449
has only substance units: false
is: P42765
type: Species
name: ACAA2
initial concentration: NaN
boundary condition: true
initial amount: NaN
is: SBO:0000252

metaM udp c
is: C00015
is: HMDB00295
is: SBO:0000247
has only substance units: false
name: UDP
notes: FORMULA: C9H11N2O12P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00025 EHMN_ABBREVIATION: C00015
initial amount: NaN
boundary condition: false
initial concentration: 1.0
is: CHEBI:58223
type: Species
constant: false

metaR r0784
product: MODEL1310110045#
modifier: MODEL1310110045#
notes: GENE_ASSOCIATION: (AA526438.1) or (H17063.1) or (51102.1) or (55825.1) SUBSYSTEM: Pentose phosphate pathway EC Number: 1.1.1.15 Confidence Level: 0 AUTHORS: PMID:13373783 NOTES:
kinetic law: MODEL1310110045#
is described by: ECO:0000000
type: Reaction
is: SBO:0000176
fast: false
is version of: http://identifiers.org/ec-code/1.3.1.38
name: xylitol:NAD oxidoreductase Pentose and glucuronate interconversions EC:1.1.1.15
reactant: MODEL1310110045#
reversible: true

metaR NDPK4n
type: Reaction
is described by: ECO:0000304
is version of: http://identifiers.org/ec-code/2.7.4.6
reversible: true
product: MODEL1310110045#
is: SBO:0000176
kinetic law: MODEL1310110045#
notes: GENE_ASSOCIATION: (4831.1 and 4830.1) or (4830.2 and 4831.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.6 Confidence Level: 4 AUTHORS: PMID:7050910 NOTES:Many nucleoside diphosphates (eight described) can act as acceptors. While many ribo- and deoxyribonucleoside triphosphates can act as donors, only ATP is chosen as a donor to minimize the number of total reactions.. Presence in the nucleus
fast: false
reactant: MODEL1310110045#
name: nucleoside-diphosphate kinase (ATP:dTDP), nuclear
modifier: MODEL1310110045#

metaR DASCBR
name: dehydroascorbate reductase
is described by: ECO:0000269
kinetic law: MODEL1310110045#
fast: false
modifier: MODEL1310110045#
type: Reaction
reactant: MODEL1310110045#
product: MODEL1310110045#
is version of: http://identifiers.org/ec-code/1.8.4.1
is: SBO:0000176
notes: GENE_ASSOCIATION: (2745.1) or (51022.2) or (51022.1) SUBSYSTEM: Vitamin C metabolism EC Number: 1.6.5.4 Confidence Level: 4 AUTHORS: PMID:11297543 NOTES:
reversible: false

metaM 3mldz c
is: HMDB04181
initial concentration: 1.0
is: SBO:0000247
constant: false
is: CHEBI:28104
notes: FORMULA: C6H8N2O CHARGE: 0 INCHI: InChI=1S/C6H8N2O/c1-8-4-6(2-3-9)7-5-8/h3-5H,2H2,1H3 EHMN_ABBREVIATION: C05827
type: Species
name: 1-methylimidazole-4-acetaldehyde
boundary condition: false
has only substance units: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110045#_72e68bfd_2739_47a6_96cf_8d2d23cceaed
has only substance units: false
initial amount: NaN
name: LDHAL6A
constant: false
is: Q6ZMR3
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:160287
boundary condition: true
type: Species

metaR r2106
product: MODEL1310110045#
modifier: MODEL1310110045#
is described by: ECO:0000000
kinetic law: MODEL1310110045#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
fast: false
type: Reaction
reversible: true
is: SBO:0000185
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
reactant: MODEL1310110045#

http://identifiers.org/biomodels.db/MODEL1310110045#_afc41491_5f4d_4dbb_8e06_edee1ed1abbe
constant: false
name: SLC27A1
is encoded by: hsa:376497
initial concentration: NaN
has only substance units: false
boundary condition: true
initial amount: NaN
type: Species
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110045#_aa851703_0577_45cf_8466_579f997ccd4e
is: SBO:0000252
is encoded by: hsa:3036
boundary condition: true
initial concentration: NaN
constant: false
initial amount: NaN
is: Q8IYH3
has only substance units: false
name: HAS1
type: Species

metaR RE3269C
fast: false
kinetic law: MODEL1310110045#
name: RE3269
is: SBO:0000176
modifier: MODEL1310110045#
product: MODEL1310110045#
reactant: MODEL1310110045#
is described by: ECO:0000000
type: Reaction
reversible: true
notes: GENE_ASSOCIATION: (8897.1) or (8897.3) or (8897.2) SUBSYSTEM: Phosphatidylinositol phosphate metabolism EC Number: 3.1.3.66 Confidence Level: 0 AUTHORS: PMID:7556092 NOTES:Recin 1 had irreversible version - PI35P3P - GPR from PI35P3P was added - May 2011 IT
is version of: http://identifiers.org/ec-code/3.1.3.48

http://identifiers.org/biomodels.db/MODEL1310110045#_40493d14_6de8_4459_ac86_67bbe6e689a1
initial concentration: NaN
has only substance units: false
boundary condition: true
constant: false
is encoded by: hsa:376497
type: Species
name: SLC27A1
initial amount: NaN
is: SBO:0000252
is: Q6PCB7

metaR r0627
is described by: ECO:0000000
is: SBO:0000176
kinetic law: MODEL1310110045#
name: Galactosylglycerol galactohydrolase Galactose metabolism EC:3.2.1.22 EC:3.2.1.23
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 3.2.1.23 Confidence Level: 0 AUTHORS: PMID:3569296 NOTES:
type: Reaction
fast: false
reactant: MODEL1310110045#
reversible: true
product: MODEL1310110045#

metaR 2AMADPTm
reversible: true
is: SBO:0000185
modifier: MODEL1310110045#
kinetic law: MODEL1310110045#
name: L-2-aminoadipate shuttle (cytosol/mitochondria)
is described by: ECO:0000269
reactant: MODEL1310110045#
product: MODEL1310110045#
fast: false
type: Reaction
notes: GENE_ASSOCIATION: (89874.1) SUBSYSTEM: Lysine metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:11083877 NOTES:SAB PMID 11083877

metaM HC01609 e
is: CHEBI:28766
constant: false
notes: FORMULA: C40H36N4O16 CHARGE: -8 INCHI: InChI=1S/C40H44N4O16/c45-33(46)5-1-17-21(9-37(53)54)29-14-26-19(3-7-35(49)50)23(11-39(57)58)31(43-26)16-28-20(4-8-36(51)52)24(12-40(59)60)32(44-28)15-27-18(2-6-34(47)48)22(10-38(55)56)30(42-27)13-25(17)41-29/h41-44H,1-16H2,(H,45,46)(H,47,48)(H,49,50)(H,51,52)(H,53,54)(H,55,56)(H,57,58)(H,59,60) EHMN_ABBREVIATION: C05766
has only substance units: false
name: UroporphyrinogenI
type: Species
initial concentration: 1.0
initial amount: NaN
is: SBO:0000247
boundary condition: false

metaM hdca e
notes: FORMULA: C16H31O2 CHARGE: -1
initial concentration: 1.0
is: HMDB00220
has only substance units: false
boundary condition: false
constant: false
initial amount: NaN
is: CHEBI:0
is: SBO:0000247
type: Species
name: Hexadecanoate (n-C16:0)
is: C00249

metaM m4mpdol L r
initial amount: NaN
initial concentration: 1.0
constant: false
type: Species
is: SBO:0000247
notes: FORMULA: C1540H2528N20O420P20 CHARGE: -20 INCHI: InChI=1S/C71H122N2O42P2/c1-30(2)13-9-14-31(3)15-10-16-32(4)17-11-18-33(5)19-12-20-34(6)21-22-101-116(96,97)115-117(98,99)114-66-45(73-36(8)81)52(88)60(42(28-79)107-66)109-65-44(72-35(7)80)51(87)61(41(27-78)106-65)110-69-59(95)62(50(86)43(108-69)29-100-67-57(93)53(89)46(82)37(23-74)102-67)111-70-64(56(92)49(85)39(25-76)104-70)113-71-63(55(91)48(84)40(26-77)105-71)112-68-58(94)54(90)47(83)38(24-75)103-68/h13,15,17,19,34,37-71,74-79,82-95H,9-12,14,16,18,20-29H2,1-8H3,(H,72,80)(H,73,81)(H,96,97)(H,98,99)/b31-15+,32-17+,33-19+/t34?,37-,38-,39-,40-,41-,42-,43-,44-,45-,46-,47-,48-,49-,50-,51-,52-,53+,54+,55+,56+,57+,58+,59+,60-,61-,62+,63+,64+,65+,66-,67+,68-,69+,70-,71-/m1/s1
name: (alpha-D-Mannosyl)4-beta-D-mannosyl-diacetylchitobiosyldiphosphodolichol, human liver homolog
boundary condition: false
has only substance units: false
is: CHEBI:37633

http://identifiers.org/biomodels.db/MODEL1310110045#_8b3a688d_cea3_46c9_9b0e_b29bb1fdb90d
is encoded by: hsa:6534
has only substance units: false
initial concentration: NaN
name: SLC6A7
is: Q99884
boundary condition: true
initial amount: NaN
type: Species
is: SBO:0000252
constant: false

metaM tsul c
notes: FORMULA: O3S2 CHARGE: -2 INCHI: InChI=1S/H2O3S2/c1-5(2,3)4/h(H2,1,2,3,4)/p-2 EHMN_ABBREVIATION: C00320
is: HMDB00257
name: thiosulfate(2-)
constant: false
initial concentration: 1.0
is: SBO:0000247
has only substance units: false
is: CHEBI:16094
boundary condition: false
type: Species
initial amount: NaN

metaR r2107
product: MODEL1310110045#
reversible: true
fast: false
is described by: ECO:0000000
kinetic law: MODEL1310110045#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
is: SBO:0000185
modifier: MODEL1310110045#
reactant: MODEL1310110045#
type: Reaction
name: Major Facilitator(MFS) TCDB:2.A.1.13.1

metaR EX o2s LPAREN e RPAREN
kinetic law: MODEL1310110045#
reactant: MODEL1310110045#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Superoxide anion exchange
type: Reaction

metaM nrpphrsf e
name: Sulfate derivative of norepinephrine
boundary condition: false
initial amount: NaN
initial concentration: 1.0
constant: false
is: http://identifiers.org/pubchem.compound/123747
is: SBO:0000247
type: Species
is: HMDB02062
notes: FORMULA: C8H11NO6S CHARGE: 0 INCHI: InChI=1/C8H11NO6S/c9-4-7(11)5-1-2-8(6(10)3-5)15-16(12,13)14/h1-3,7,10-11H,4,9H2,(H,12,13,14)/t7-/m0/s1
has only substance units: false

metaR GLUDxm
notes: GENE_ASSOCIATION: (2747.1) or (2746.1) SUBSYSTEM: Glutamate metabolism EC Number: 1.4.1.3 Confidence Level: 4 AUTHORS: PMID:12324473,PMID:3368458 NOTES:
reactant: MODEL1310110045#
type: Reaction
is: SBO:0000176
modifier: MODEL1310110045#
product: MODEL1310110045#
reversible: true
kinetic law: MODEL1310110045#
is described by: ECO:0000269
name: glutamate dehydrogenase (NAD) (mitochondrial)
fast: false
is version of: http://identifiers.org/ec-code/1.4.1.3

metaM apoC c
initial amount: NaN
name: Apocarboxlase (no lys residue)
boundary condition: false
has only substance units: false
initial concentration: 1.0
notes: FORMULA: XH CHARGE: 0
is: HMDB11111
is: SBO:0000247
constant: false
type: Species
is: CHEBI:33190

http://identifiers.org/biomodels.db/MODEL1310110045#_47253fda_9408_4785_91d4_07e7e42ba5a8
constant: false
initial concentration: NaN
has only substance units: false
initial amount: NaN
name: HADHA
is: SBO:0000252
boundary condition: true
type: Species
is: E9KL44
is encoded by: hsa:3030

metaR r1156
notes: GENE_ASSOCIATION: SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.1.48 Confidence Level: 0 AUTHORS: PMID:11306702,PMID:11494055,PMID:64250,PMID:9923963 NOTES:
kinetic law: MODEL1310110045#
reversible: true
fast: false
type: Reaction
is: SBO:0000176
product: MODEL1310110045#
name: dUTP:uridine 5-phosphotransferase Pyrimidine metabolism EC:2.7.1.48
reactant: MODEL1310110045#
is described by: ECO:0000000

metaR 10FTHFtm
name: 10-Formyltetrahydrofolate mitochondrial transport via diffusion
reactant: MODEL1310110045#
is: SBO:0000185
reversible: true
fast: false
is described by: ECO:0000000
kinetic law: MODEL1310110045#
type: Reaction
product: MODEL1310110045#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: PMID:11375437 NOTES:NCD

http://identifiers.org/biomodels.db/MODEL1310110045#_18718ceb_89d2_404f_907c_740d9ad74f03
is: SBO:0000252
initial concentration: NaN
constant: false
name: B3GNT6
type: Species
initial amount: NaN
is: A8K9Q8
is encoded by: hsa:192134
boundary condition: true
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110045#_2aa33b50_f222_45b9_9f43_4d61ed0f087e
has only substance units: false
constant: false
is encoded by: hsa:79646
is: SBO:0000252
initial amount: NaN
type: Species
is: Q9H999
name: PANK3
initial concentration: NaN
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110045#_be5bd940_f333_42b5_a37b_b4cd9cd31feb
boundary condition: true
is: B4DER4
initial concentration: NaN
is encoded by: hsa:5291
name: PIK3CB
is: SBO:0000252
initial amount: NaN
has only substance units: false
constant: false
type: Species

metaR r2108
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
is described by: ECO:0000000
product: MODEL1310110045#
modifier: MODEL1310110045#
type: Reaction
fast: false
is: SBO:0000185
kinetic law: MODEL1310110045#
reactant: MODEL1310110045#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110045#_6702b3cc_0b4c_4b78_9f6b_fc5221b1ac44
type: Species
constant: false
initial concentration: NaN
boundary condition: true
initial amount: NaN
is: P21912
is encoded by: hsa:6390
is: SBO:0000252
name: SDHB
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110045#_066a9669_ef75_4f31_8766_0c6cff2175c9
constant: false
type: Species
is encoded by: hsa:AL038231
name: _AL038231_1_c
initial concentration: NaN
initial amount: NaN
has only substance units: false
is: SBO:0000252
boundary condition: true

metaR r0483
kinetic law: MODEL1310110045#
reversible: true
type: Reaction
is described by: ECO:0000000
product: MODEL1310110045#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Pyrimidine catabolism EC Number: 2.6.1.22 Confidence Level: 0 AUTHORS: PMID:5773299 NOTES:
is: SBO:0000176
reactant: MODEL1310110045#
name: (R)-3-Amino-2-methylpropanoate:2-oxoglutarate aminotransferase EC:2.6.1.22

metaR r0629
fast: false
kinetic law: MODEL1310110045#
type: Reaction
reversible: true
is version of: http://identifiers.org/ec-code/3.1.4.1
reactant: MODEL1310110045#
product: MODEL1310110045#
is version of: http://identifiers.org/ec-code/3.6.1.22
notes: GENE_ASSOCIATION: (AI926493.1) or (5167.1) or (5169.1) or (83594.1) SUBSYSTEM: Bile acid synthesis EC Number: 2.3.1.65 Confidence Level: 0 AUTHORS: PMID:10884298,PMID:12239217,PMID:12543708,PMID:15026425,PMID:3741411,PMID:6884990 NOTES:
name: Choloyl-CoA:glycine N-choloyltransferase Bile acid biosynthesis / Taurine and hypotaurine metabolism EC:2.3.1.65
modifier: MODEL1310110045#
is described by: ECO:0000000
is: SBO:0000176

metaR XOLDIOLONEt
kinetic law: MODEL1310110045#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: PMID:12840657 NOTES:cholesterol precursor, transport by "diffusion" -> actually beleived to be flip-flop mechanism (PMID: 12840657). NJ
is: SBO:0000185
product: MODEL1310110045#
fast: false
type: Reaction
reversible: true
name: lipid, flip-flop intracellular transport
reactant: MODEL1310110045#
is described by: ECO:0000000

metaR r1155
fast: false
product: MODEL1310110045#
is: SBO:0000185
name: TCDB:2.A.1.13.5 TCDB:2.A.1.13.1
reactant: MODEL1310110045#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:12107270,PMID:12739169,PMID:12829793,PMID:17245649,PMID:18375207,PMID:8476015,PMID:8557697,PMID:9786900 NOTES:
kinetic law: MODEL1310110045#
reversible: false
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110045#_22387a0a_2a43_415d_b8a2_c72629f3980b
constant: false
type: Species
initial concentration: NaN
name: TUSC3
initial amount: NaN
is encoded by: hsa:7991
boundary condition: true
has only substance units: false
is: Q13454
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110045#_1147b258_d681_468e_b5c0_a2453e98a009
is: D9HTE9
constant: false
has only substance units: false
initial amount: NaN
initial concentration: NaN
name: SLC25A1
boundary condition: true
type: Species
is: SBO:0000252
is encoded by: hsa:6576

http://identifiers.org/biomodels.db/MODEL1310110045#_045abde6_dabf_459e_b314_2517a8d4f9c8
is: SBO:0000252
constant: false
initial concentration: NaN
has only substance units: false
is encoded by: hsa:4724
name: NDUFS4
initial amount: NaN
boundary condition: true
is: O43181
type: Species

http://identifiers.org/biomodels.db/MODEL1310110045#_b2f10810_b2ec_4347_a6b7_d4f0ff759357
is: B3KT86
initial amount: NaN
type: Species
has only substance units: false
name: ADCY3
is encoded by: hsa:109
boundary condition: true
is: SBO:0000252
initial concentration: NaN
constant: false

metaR r2109
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
modifier: MODEL1310110045#
is: SBO:0000185
reactant: MODEL1310110045#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
kinetic law: MODEL1310110045#
type: Reaction
fast: false
product: MODEL1310110045#
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110045#_062d7078_5172_4d9b_848b_65c337989451
is: A8K5Z0
is encoded by: hsa:8703
has only substance units: false
boundary condition: true
name: B4GALT3
constant: false
initial amount: NaN
is: SBO:0000252
type: Species
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110045#_565e1bb2_6513_4747_bfa9_64f2c3a120ca
boundary condition: true
is encoded by: hsa:89869
has only substance units: false
is: Q86YW0
initial amount: NaN
is: SBO:0000252
type: Species
constant: false
name: PLCZ1
initial concentration: NaN

metaR r0787
is version of: http://identifiers.org/ec-code/1.1.1.1
type: Reaction
product: MODEL1310110045#
reversible: false
modifier: MODEL1310110045#
is described by: ECO:0000000
kinetic law: MODEL1310110045#
reactant: MODEL1310110045#
is: SBO:0000176
fast: false
name: 3-sn-phosphatidate phosphohydrolase Sphingolipid metabolism EC:3.1.3.4
notes: GENE_ASSOCIATION: (124.1) or (125.1) or (128.1) or (130.1) or (131.1) or (AI291895.1) or (M68895.1) or (X63359.1) SUBSYSTEM: Sphingolipid metabolism EC Number: 3.1.3.4 Confidence Level: 0 AUTHORS: PMID:7575445 NOTES:

metaR r1154
type: Reaction
reversible: true
is: SBO:0000176
name: EC:1.2.7.2
product: MODEL1310110045#
reactant: MODEL1310110045#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Propanoate metabolism EC Number: 1.2.7.2 Confidence Level: 0 AUTHORS: PMID:2649080,PMID:283398,PMID:3718468,PMID:9381974 NOTES:
fast: false
kinetic law: MODEL1310110045#

metaM nac e
boundary condition: false
initial amount: NaN
has only substance units: false
is: C00253
is: HMDB01488
constant: false
notes: FORMULA: C6H4NO2 CHARGE: -1
is: SBO:0000247
initial concentration: 1.0
name: Nicotinate
is: CHEBI:0
type: Species

metaM citr L e
has only substance units: false
initial amount: NaN
is: CHEBI:16349
type: Species
is: HMDB00904
name: citr_L[e]
notes: FORMULA: C6H13N3O3 CHARGE: 0 INCHI: InChI=1S/C6H13N3O3/c7-4(5(10)11)2-1-3-9-6(8)12/h4H,1-3,7H2,(H,10,11)(H3,8,9,12)/t4-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00277
initial concentration: 1.0
boundary condition: false
is: SBO:0000247
constant: false

http://identifiers.org/biomodels.db/MODEL1310110045#_9c71b2a8_ce41_49ea_a259_eff24b374ff1
constant: false
is: SBO:0000252
initial amount: NaN
boundary condition: true
type: Species
has only substance units: false
is: O75874
name: IDH1
is encoded by: hsa:3417
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110045#_618be554_f524_48d8_b8ad_841a5da2245f
is encoded by: hsa:8898
name: MTMR2
boundary condition: true
has only substance units: false
initial amount: NaN
type: Species
is: SBO:0000252
constant: false
is: A6NN98
initial concentration: NaN

metaR ALAtN1
fast: false
is: SBO:0000185
type: Reaction
reversible: true
modifier: MODEL1310110045#
is described by: ECO:0000269
product: MODEL1310110045#
notes: GENE_ASSOCIATION: (92745.1) or (10991.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10823827,PMID:12845534 NOTES:SAB based om PMID 10823827
kinetic law: MODEL1310110045#
name: Alanine transport (Na, H coupled)
reactant: MODEL1310110045#

metaR r0780
reactant: MODEL1310110045#
product: MODEL1310110045#
notes: GENE_ASSOCIATION: (30.1) or (10449.1) or (3032.1) or (4645.1) SUBSYSTEM: Cholesterol metabolism EC Number: 1.3.1.70 Confidence Level: 0 AUTHORS: PMID:11969204,PMID:7946524 NOTES:
kinetic law: MODEL1310110045#
fast: false
reversible: true
is described by: ECO:0000000
modifier: MODEL1310110045#
type: Reaction
is: SBO:0000176
name: 4,4-dimethyl-5a-cholesta-8,24-dien-3b-ol:NADP+ D14-oxidoreductase Biosynthesis of steroids EC:1.3.1.70
is version of: http://identifiers.org/ec-code/2.3.1.16

http://identifiers.org/biomodels.db/MODEL1310110045#_24c8e67a_fbca_4f0f_ba3d_4ff00e445bcc
has only substance units: false
is: SBO:0000252
boundary condition: true
is: Q9UQ53
type: Species
initial concentration: NaN
is encoded by: hsa:11282
initial amount: NaN
constant: false
name: MGAT4B

http://identifiers.org/biomodels.db/MODEL1310110045#_6de76191_b695_468b_8073_a874ce458a09
name: LIPC
is encoded by: hsa:3990
boundary condition: true
is: SBO:0000252
initial concentration: NaN
initial amount: NaN
constant: false
has only substance units: false
is: A6H8L5
type: Species

metaR r2102
reactant: MODEL1310110045#
type: Reaction
fast: false
is: SBO:0000185
is described by: ECO:0000000
reversible: true
kinetic law: MODEL1310110045#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
modifier: MODEL1310110045#
product: MODEL1310110045#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:

metaR ASPDTDe
type: Reaction
is: SBO:0000185
reactant: MODEL1310110045#
name: D-aspartate transport, extracellular
is described by: ECO:0000134
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: D-aspartate may exit by diffusion or require specific transporters. NOTES:D-aspartate may exit by diffusion or require specific transporters.
fast: false
kinetic law: MODEL1310110045#
product: MODEL1310110045#
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110045#_a856c36e_fb6a_4d36_842f_982b6e87d7f0
type: Species
has only substance units: false
name: PRDX3
is: P30048
boundary condition: true
is encoded by: hsa:10935
is: SBO:0000252
constant: false
initial concentration: NaN
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110045#_77ccf8cc_09ad_4bd5_b6c9_dc7578e3494f
constant: false
boundary condition: true
is: SBO:0000252
initial amount: NaN
name: _H77542_1_c
type: Species
has only substance units: false
is encoded by: hsa:H77542
initial concentration: NaN

metaR PMANM
type: Reaction
is version of: http://identifiers.org/ec-code/5.4.2.8
is: SBO:0000176
reversible: true
is version of: http://identifiers.org/ec-code/5.4.2.2
kinetic law: MODEL1310110045#
name: phosphomannomutase
modifier: MODEL1310110045#
notes: GENE_ASSOCIATION: (5372.1) or (55276.1) or (5373.1) SUBSYSTEM: Fructose and mannose metabolism EC Number: 5.4.2.8 Confidence Level: 0 AUTHORS: NOTES:
reactant: MODEL1310110045#
product: MODEL1310110045#
fast: false
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110045#_2156ced0_570c_4ae2_9869_87b3bca5a6fc
initial concentration: NaN
has only substance units: false
is: SBO:0000252
boundary condition: true
name: OGDH
is: Q02218
initial amount: NaN
type: Species
constant: false
is encoded by: hsa:4967

metaR GLCAASE5ly
reversible: false
modifier: MODEL1310110045#
reactant: MODEL1310110045#
type: Reaction
is: SBO:0000176
kinetic law: MODEL1310110045#
is version of: http://identifiers.org/ec-code/3.2.1.31
product: MODEL1310110045#
fast: false
name: beta-glucuronidase, lysosomal
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (2990.1) SUBSYSTEM: Chondroitin sulfate degradation EC Number: 3.2.1.31 Confidence Level: 4 AUTHORS: PMID:3468507,PMID:3924735,PMID:3987656 NOTES:NCD

metaM aps c
boundary condition: false
initial amount: NaN
is: SBO:0000247
constant: false
initial concentration: 1.0
type: Species
notes: FORMULA: C10H12N5O10PS CHARGE: -2 INCHI: InChI=1S/C10H14N5O10PS/c11-8-5-9(13-2-12-8)15(3-14-5)10-7(17)6(16)4(24-10)1-23-26(18,19)25-27(20,21)22/h2-4,6-7,10,16-17H,1H2,(H,18,19)(H2,11,12,13)(H,20,21,22)/p-2/t4-,6-,7-,10-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00204 EHMN_ABBREVIATION: C00224
has only substance units: false
name: 5'-adenylyl sulfate(2-)
is: CHEBI:58243
is: HMDB01003

http://identifiers.org/biomodels.db/MODEL1310110045#_b5b423e0_57eb_48e2_a224_cadd73404944
initial concentration: NaN
type: Species
constant: false
initial amount: NaN
is: Q13232
is encoded by: hsa:4832
has only substance units: false
boundary condition: true
name: NME3
is: SBO:0000252

metaM ksii core4 pre8 g
notes: FORMULA: C83H134N7O61SX CHARGE: -2
initial amount: NaN
has only substance units: false
is: HMDB00175
boundary condition: false
constant: false
is: C00130
is: CHEBI:58053
name: keratan sulfate II biosynthesis, precursor 8
is: SBO:0000247
type: Species
initial concentration: 1.0

metaR OMPDC
notes: GENE_ASSOCIATION: (7372.1) SUBSYSTEM: Pyrimidine synthesis EC Number: 4.1.1.23 Confidence Level: 4 AUTHORS: PMID:3279416,PMID:6574608,PMID:6893554,PMID:9042911 NOTES:
product: MODEL1310110045#
is: SBO:0000176
reversible: false
modifier: MODEL1310110045#
kinetic law: MODEL1310110045#
reactant: MODEL1310110045#
fast: false
name: orotidine-5'-phosphate decarboxylase
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/2.4.2.10
type: Reaction

metaR r2103
type: Reaction
kinetic law: MODEL1310110045#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
is described by: ECO:0000000
product: MODEL1310110045#
reactant: MODEL1310110045#
reversible: true
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
fast: false
modifier: MODEL1310110045#
is: SBO:0000185

metaM citr L c
has only substance units: false
is: SBO:0000247
initial amount: NaN
constant: false
boundary condition: false
notes: FORMULA: C6H13N3O3 CHARGE: 0 INCHI: InChI=1S/C6H13N3O3/c7-4(5(10)11)2-1-3-9-6(8)12/h4H,1-3,7H2,(H,10,11)(H3,8,9,12)/t4-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00277
type: Species
is: HMDB00904
initial concentration: 1.0
is: CHEBI:16349
name: L-citrulline

metaM malt c
name: Maltose
is: CHEBI:17306
boundary condition: false
notes: FORMULA: C12H22O11 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00194 EHMN_ABBREVIATION: C00208
initial concentration: 1.0
has only substance units: false
type: Species
is: C00208
constant: false
initial amount: NaN
is: HMDB00163
is: SBO:0000247

metaR CYOOm3
reactant: MODEL1310110045#
modifier: MODEL1310110045#
is version of: http://identifiers.org/ec-code/1.9.3.1
fast: false
name: cytochrome c oxidase, mitochondrial Complex IV
kinetic law: MODEL1310110045#
reversible: false
is: SBO:0000185
type: Reaction
notes: GENE_ASSOCIATION: (1351.1) and (1347.1) and (1329.1) and (1327.1) and (341947.1) and (9167.1) and (1350.1) and (4512.1) and (1349.1) and (1339.1) and (1345.1) and (4513.1) and (9377.1) and (125965.1) and (4514.1) and (170712.1) and (1346.1) and (1340.1) and (84701.1) and (1337.1) SUBSYSTEM: Oxidative phosphorylation EC Number: Confidence Level: 4 AUTHORS: PMID:10869362,PMID:12241082 NOTES:TV, 2% O2 lost in O2-
product: MODEL1310110045#
is described by: ECO:0000134

metaR SPH1Pte
reversible: true
name: sph1p transport
is: SBO:0000185
kinetic law: MODEL1310110045#
product: MODEL1310110045#
reactant: MODEL1310110045#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:15585321 NOTES:unknown mechanism for transport, may be vesicular/caveolar/other ... intracellular transport and extracellular export mechanisms must exist - see for example: PMID: 15585321 NJ
is described by: ECO:0000000
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110045#_ede1bcad_5822_4f72_9a1d_6aa2c11b5de7
boundary condition: true
has only substance units: false
name: DGKD
initial concentration: NaN
type: Species
is encoded by: hsa:8527
initial amount: NaN
is: SBO:0000252
constant: false

metaR PCm
product: MODEL1310110045#
modifier: MODEL1310110045#
type: Reaction
is: SBO:0000176
kinetic law: MODEL1310110045#
reactant: MODEL1310110045#
notes: GENE_ASSOCIATION: (5091.1) or (5091.2) SUBSYSTEM: Pyruvate metabolism EC Number: 6.4.1.1 Confidence Level: 4 AUTHORS: PMID:6548474 NOTES:TV Metabolism at a glance
reversible: false
is described by: ECO:0000269
name: pyruvate carboxylase
fast: false
is version of: http://identifiers.org/ec-code/6.4.1.1

metaR EX tre LPAREN e RPAREN
kinetic law: MODEL1310110045#
reactant: MODEL1310110045#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Trehalose exchange
type: Reaction

metaR r2104
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
fast: false
is: SBO:0000185
is described by: ECO:0000000
reversible: true
kinetic law: MODEL1310110045#
product: MODEL1310110045#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
modifier: MODEL1310110045#
reactant: MODEL1310110045#
type: Reaction

metaR r2105
reversible: true
is described by: ECO:0000000
fast: false
kinetic law: MODEL1310110045#
reactant: MODEL1310110045#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
modifier: MODEL1310110045#
is: SBO:0000185
type: Reaction
product: MODEL1310110045#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1

metaM nrpphrsf c
is: HMDB02062
is: http://identifiers.org/pubchem.compound/123747
is: SBO:0000247
initial amount: NaN
notes: FORMULA: C8H11NO6S CHARGE: 0 INCHI: InChI=1/C8H11NO6S/c9-4-7(11)5-1-2-8(6(10)3-5)15-16(12,13)14/h1-3,7,10-11H,4,9H2,(H,12,13,14)/t7-/m0/s1
constant: false
has only substance units: false
type: Species
boundary condition: false
name: Sulfate derivative of norepinephrine
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110045#_43440154_a337_4642_b5e9_31eeb03d818a
constant: false
is encoded by: hsa:33
is: SBO:0000252
type: Species
initial amount: NaN
boundary condition: true
initial concentration: NaN
is: P28330
has only substance units: false
name: ACADL

metaM ha e
name: hyaluronan
is: SBO:0000247
constant: false
type: Species
has only substance units: false
initial concentration: 1.0
boundary condition: false
is: CHEBI:16336
initial amount: NaN
notes: FORMULA: C28H40N2O22 CHARGE: -2 EHMN_ABBREVIATION: C00518

metaM tsul e
type: Species
name: thiosulfate(2-)
is: HMDB00257
has only substance units: false
boundary condition: false
is: CHEBI:16094
constant: false
initial concentration: 1.0
initial amount: NaN
notes: FORMULA: O3S2 CHARGE: -2 INCHI: InChI=1S/H2O3S2/c1-5(2,3)4/h(H2,1,2,3,4)/p-2 EHMN_ABBREVIATION: C00320
is: SBO:0000247

metaR r0783
notes: GENE_ASSOCIATION: (1892.1) or (1962.1) or (3030.1) SUBSYSTEM: Cholesterol metabolism EC Number: 1.3.1.72 Confidence Level: 0 AUTHORS: PMID:7946524 NOTES:
reversible: true
kinetic law: MODEL1310110045#
fast: false
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/1.1.1.35
is version of: http://identifiers.org/ec-code/4.2.1.17
reactant: MODEL1310110045#
type: Reaction
is: SBO:0000176
product: MODEL1310110045#
modifier: MODEL1310110045#
name: lanosterol D24-reductase Biosynthesis of steroids EC:1.3.1.72

metaR RE2649C
name: RE2649
reversible: true
is described by: ECO:0000000
modifier: MODEL1310110045#
is version of: http://identifiers.org/ec-code/3.1.2.2
reactant: MODEL1310110045#
kinetic law: MODEL1310110045#
fast: false
notes: GENE_ASSOCIATION: (641372.1) or (641371.1) or (570.1) SUBSYSTEM: Bile acid synthesis EC Number: 3.1.2.2 Confidence Level: 0 AUTHORS: PMID:11013297 NOTES:
is version of: http://identifiers.org/ec-code/2.3.1.65
type: Reaction
product: MODEL1310110045#
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110045#_02b5e592_1eb3_44d8_91af_3dc55f109582
has only substance units: false
initial concentration: NaN
is: SBO:0000252
constant: false
boundary condition: true
name: NME6
initial amount: NaN
type: Species
is: O75414
is encoded by: hsa:10201

metaR EX gchola LPAREN e RPAREN
kinetic law: MODEL1310110045#
reactant: MODEL1310110045#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Glycocholate exchange
type: Reaction

metaM malttr e
boundary condition: false
has only substance units: false
is: SBO:0000247
initial concentration: 1.0
is: CHEBI:27931
name: maltotriose
is: C01835
type: Species
notes: FORMULA: C18H32O16 CHARGE: 0 INCHI: InChI=1S/C18H32O16/c19-1-4-7(22)8(23)12(27)17(31-4)34-15-6(3-21)32-18(13(28)10(15)25)33-14-5(2-20)30-16(29)11(26)9(14)24/h4-29H,1-3H2/t4-,5-,6-,7-,8+,9-,10-,11-,12-,13-,14-,15-,16+,17-,18-/m1/s1 EHMN_ABBREVIATION: C01835
constant: false
is: HMDB01262
initial amount: NaN

metaR r0488
fast: false
type: Reaction
kinetic law: MODEL1310110045#
reactant: MODEL1310110045#
is described by: ECO:0000000
name: (R)-Mevalonate:NADP+ oxidoreductase (CoA acylating) Biosynthesis of steroids EC:1.1.1.34
product: MODEL1310110045#
reversible: true
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Cholesterol metabolism EC Number: 1.1.1.34 Confidence Level: 0 AUTHORS: PMID:10698924,PMID:11108725,PMID:12454262,PMID:3745272,PMID:3883347 NOTES:

metaR GTHDH
is: SBO:0000176
is described by: ECO:0000134
product: MODEL1310110045#
fast: false
name: Glutathione dehydrogenase (dehydroascorbate reductase)
reactant: MODEL1310110045#
reversible: false
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Vitamin C metabolism EC Number: Confidence Level: 2 AUTHORS: PMID:15970797,PMID:16399380 NOTES:NCD. activity catalyzed by GSTO2-2
kinetic law: MODEL1310110045#

metaR EX HC02204 LPAREN e RPAREN
kinetic law: MODEL1310110045#
reactant: MODEL1310110045#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: prostaglandin-b1 exchange
type: Reaction

metaM pro L m
is: CHEBI:17203
is: HMDB00162
type: Species
initial amount: NaN
boundary condition: false
has only substance units: false
notes: FORMULA: C5H9NO2 CHARGE: 0 INCHI: InChI=1S/C5H9NO2/c7-5(8)4-2-1-3-6-4/h4,6H,1-3H2,(H,7,8)/t4-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00145
name: L-proline
constant: false
is: SBO:0000247
initial concentration: 1.0

metaM dectricoa m
is: SBO:0000247
constant: false
notes: FORMULA: C31H44N7O17P3S CHARGE: -4
name: 2,4,7-decatrienoylcoa
boundary condition: false
type: Species
initial amount: NaN
has only substance units: false
initial concentration: 1.0
is: http://identifiers.org/pubchem.compound/16019966

http://identifiers.org/biomodels.db/MODEL1310110045#_0a50cc43_351b_4da2_bcd9_c7988aaf4968
boundary condition: true
is: Q969I6
is encoded by: hsa:55089
type: Species
has only substance units: false
is: SBO:0000252
initial amount: NaN
initial concentration: NaN
constant: false
name: SLC38A4

http://identifiers.org/biomodels.db/MODEL1310110045#_2bbd1052_c6a5_4c60_adf0_09344e24a5f8
is: SBO:0000252
initial concentration: NaN
name: NDUFB6
constant: false
boundary condition: true
is: O95139
initial amount: NaN
has only substance units: false
type: Species
is encoded by: hsa:4712

metaR RETFA
type: Reaction
reactant: MODEL1310110045#
reversible: false
product: MODEL1310110045#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Vitamin A metabolism EC Number: 2.3.1.76 Confidence Level: 2 AUTHORS: PMID:1503811 NOTES:IT
fast: false
is: SBO:0000176
name: retinol acyltransferase
kinetic law: MODEL1310110045#

metaR HMGCOAtx
name: Hydroxymethylglutaryl-CoA reversible peroxisomal transport
product: MODEL1310110045#
is: SBO:0000185
kinetic law: MODEL1310110045#
fast: false
reversible: true
is described by: ECO:0000000
reactant: MODEL1310110045#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: PMID:14713247 NOTES:diffusion NJ
type: Reaction

metaR RE2626M
notes: GENE_ASSOCIATION: (1593.1) SUBSYSTEM: Bile acid synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:9210654,PMID:9660774 NOTES:
kinetic law: MODEL1310110045#
product: MODEL1310110045#
reversible: true
is version of: http://identifiers.org/ec-code/1.14.13.15
fast: false
reactant: MODEL1310110045#
is described by: ECO:0000000
name: RE2626
type: Reaction
is: SBO:0000176
modifier: MODEL1310110045#

metaR EX ha pre1 LPAREN e RPAREN
kinetic law: MODEL1310110045#
reactant: MODEL1310110045#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: hyaluronan biosynthesis, precursor 1 exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110045#_69aa0810_eb74_410e_84e9_15c75e542068
initial amount: NaN
type: Species
is encoded by: hsa:286016
name: TPI1P2
boundary condition: true
initial concentration: NaN
has only substance units: false
constant: false
is: SBO:0000252

metaM g2m8masn r
notes: FORMULA: C82H137N2O65X CHARGE: 0
type: Species
has only substance units: false
name: (alpha-D-Glucosyl)2-(alpha-D-mannosyl)8-beta-D-mannosyl-diacetylchitobiosyl-L-asparagine (protein)
initial amount: NaN
is: C05874
is: SBO:0000247
boundary condition: false
constant: false
initial concentration: 1.0

metaR GHMT2r
reactant: MODEL1310110045#
is described by: ECO:0000269
modifier: MODEL1310110045#
kinetic law: MODEL1310110045#
reversible: true
is: SBO:0000176
product: MODEL1310110045#
name: glycine hydroxymethyltransferase, reversible
type: Reaction
fast: false
notes: GENE_ASSOCIATION: (6470.1) or (6470.2) SUBSYSTEM: Glycine, serine, alanine and threonine metabolism EC Number: 2.1.2.1 Confidence Level: 4 AUTHORS: PMID:8505317,PMID:8611185,PMID:9038835 NOTES:NCD
is version of: http://identifiers.org/ec-code/2.1.2.1

metaR UMPK2n
is version of: http://identifiers.org/ec-code/2.7.4.14
is: SBO:0000176
reversible: true
modifier: MODEL1310110045#
kinetic law: MODEL1310110045#
type: Reaction
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
name: UMP kinase (CTP),nuclear
is described by: ECO:0000269
reactant: MODEL1310110045#
fast: false
product: MODEL1310110045#

metaM ksi deg36 l
notes: FORMULA: C62H103N4O49S1 CHARGE: -1
is: HMDB00143
has only substance units: false
boundary condition: false
name: keratan sulfate I, degradation product 36
initial concentration: 1.0
constant: false
type: Species
initial amount: NaN
is: SBO:0000247
is: CHEBI:12936

metaR ACALDt
reversible: true
reactant: MODEL1310110045#
name: acetaldehyde reversible transport
product: MODEL1310110045#
is described by: ECO:0000000
is: SBO:0000185
fast: false
type: Reaction
kinetic law: MODEL1310110045#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:NCD

metaR APOC LYS BTNPm
reversible: false
kinetic law: MODEL1310110045#
is described by: ECO:0000000
product: MODEL1310110045#
notes: GENE_ASSOCIATION: SUBSYSTEM: Biotin metabolism EC Number: Confidence Level: 2 AUTHORS: NOTES:
type: Reaction
name: proteolysis of apoC-Lys-btn, mitochondrial
is: SBO:0000176
reactant: MODEL1310110045#
fast: false

metaR r1260
name: EC:6.2.1.3
type: Reaction
fast: false
is: SBO:0000176
reversible: false
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 0 AUTHORS: PMID:8584017 NOTES:
kinetic law: MODEL1310110045#
reactant: MODEL1310110045#
product: MODEL1310110045#

http://identifiers.org/biomodels.db/MODEL1310110045#_4d51fa76_6b41_45a3_8a33_43f3c69d6950
type: Species
initial amount: NaN
initial concentration: NaN
boundary condition: true
has only substance units: false
is: P30837
is: SBO:0000252
is encoded by: hsa:219
name: ALDH1B1
constant: false

metaR r2100
modifier: MODEL1310110045#
is: SBO:0000185
is described by: ECO:0000000
reactant: MODEL1310110045#
kinetic law: MODEL1310110045#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
product: MODEL1310110045#
fast: false
reversible: true
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
type: Reaction

metaR FAOXC227C226m
kinetic law: MODEL1310110045#
product: MODEL1310110045#
reactant: MODEL1310110045#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C22:7-->C22:6)m
type: Reaction

metaR EX HC01444 LPAREN e RPAREN
kinetic law: MODEL1310110045#
reactant: MODEL1310110045#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of Galactosylglycerol
type: Reaction

metaM dadp n
constant: false
has only substance units: false
boundary condition: false
notes: FORMULA: C10H12N5O9P2 CHARGE: -3 INCHI: InChI=1S/C10H15N5O9P2/c11-9-8-10(13-3-12-9)15(4-14-8)7-1-5(16)6(23-7)2-22-26(20,21)24-25(17,18)19/h3-7,16H,1-2H2,(H,20,21)(H2,11,12,13)(H2,17,18,19)/p-3/t5-,6+,7+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00192 EHMN_ABBREVIATION: C00206
name: dADP(3-)
initial concentration: 1.0
is: SBO:0000247
type: Species
is: CHEBI:57667
is: HMDB01508
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110045#_f2020927_433c_4fa2_85f2_a3eb36240a28
type: Species
boundary condition: true
initial amount: NaN
is: E9PB82
is: SBO:0000252
name: HSD17B4
constant: false
is encoded by: hsa:3295
has only substance units: false
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110045#_42f8040b_808a_4c84_aa83_3327adba6dd1
boundary condition: true
type: Species
constant: false
name: FLAD1
has only substance units: false
is: SBO:0000252
is: Q8NFF5
initial concentration: NaN
is encoded by: hsa:80308
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110045#_8a8a831c_13f0_4800_ad40_0c86b5107cfa
constant: false
is: P07451
is encoded by: hsa:761
initial amount: NaN
type: Species
boundary condition: true
is: SBO:0000252
has only substance units: false
name: CA3
initial concentration: NaN

metaR ECOAH12m
is described by: ECO:0000304
is version of: http://identifiers.org/ec-code/4.2.1.17
is version of: http://identifiers.org/ec-code/2.3.1.16
notes: GENE_ASSOCIATION: (1892.1) or (3030.1) and (3032.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 4.2.1.17 Confidence Level: 2 AUTHORS: PMID:9073515 NOTES:MM. based on assigned short chain enoyl-CoA hydratase activity
type: Reaction
kinetic law: MODEL1310110045#
reversible: true
product: MODEL1310110045#
reactant: MODEL1310110045#
modifier: MODEL1310110045#
is: SBO:0000176
fast: false
name: 3-hydroxyacyl-CoA dehydratase (3-hydroxyisobutyryl-CoA) (mitochondria)

http://identifiers.org/biomodels.db/MODEL1310110045#_c97ecfba_2a3c_43f8_9dc3_7fe60c323878
constant: false
boundary condition: true
type: Species
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:2348
has only substance units: false
initial amount: NaN
name: FOLR1

metaM galside hs l
name: D-galactosyl-N-acylsphingosine
has only substance units: false
notes: FORMULA: C24H46NO7FULLRCO CHARGE: 0 EHMN_ABBREVIATION: C02686
is: CHEBI:12947
constant: false
type: Species
initial concentration: 1.0
initial amount: NaN
is: SBO:0000247
boundary condition: false

metaR 2HBO
notes: GENE_ASSOCIATION: (92483.1) or (3948.2) or (55293.1) or (3945.1 and 3939.1) or (3939.1) or (160287.1) or (3945.1) or (3948.1) SUBSYSTEM: Propanoate metabolism EC Number: 1.1.1.27 Confidence Level: 4 AUTHORS: PMID:10108,PMID:21765 NOTES:NCD
is version of: http://identifiers.org/ec-code/1.1.1.27
name: 2-Hydroxybutyrate:NAD+ oxidoreductase
reversible: true
type: Reaction
is described by: ECO:0000269
is: SBO:0000176
fast: false
modifier: MODEL1310110045#
product: MODEL1310110045#
kinetic law: MODEL1310110045#
reactant: MODEL1310110045#

metaR r2101
reactant: MODEL1310110045#
type: Reaction
product: MODEL1310110045#
kinetic law: MODEL1310110045#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
reversible: true
is: SBO:0000185
fast: false
modifier: MODEL1310110045#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1

metaM apoC m
has only substance units: false
notes: FORMULA: XH CHARGE: 0
is: CHEBI:32551
constant: false
is: HMDB00182
type: Species
initial amount: NaN
name: Apocarboxlase (no lys residue)
is: SBO:0000247
boundary condition: false
initial concentration: 1.0

metaM prostge2 e
is: CHEBI:606564
boundary condition: false
type: Species
notes: FORMULA: C20H31O5 CHARGE: -1 INCHI: InChI=1S/C20H32O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h4,7,12-13,15-17,19,21,23H,2-3,5-6,8-11,14H2,1H3,(H,24,25)/p-1/b7-4-,13-12+/t15-,16+,17+,19+/m0/s1 EHMN_ABBREVIATION: C00584
is: HMDB01220
name: prostaglandin E2(1-)
constant: false
initial amount: NaN
is: SBO:0000247
has only substance units: false
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110045#_3456aff0_bc7a_43d5_8abd_938715651ae8
boundary condition: true
is: A7E2E0
is: SBO:0000252
constant: false
type: Species
name: PIK3CD
has only substance units: false
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:5293

metaM CE4794 m
constant: false
type: Species
is: SBO:0000247
boundary condition: false
name: cis-6-dodecenoyl-CoA
is: CHEBI:57923
initial amount: NaN
has only substance units: false
initial concentration: 1.0
notes: FORMULA: C33H52N7O17P3S CHARGE: -4 INCHI: InChI=1/C33H56N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-24(42)61-17-16-35-23(41)14-15-36-31(45)28(44)33(2,3)19-54-60(51,52)57-59(49,50)53-18-22-27(56-58(46,47)48)26(43)32(55-22)40-21-39-25-29(34)37-20-38-30(25)40/h8-9,20-22,26-28,32,43-44H,4-7,10-19H2,1-3H3,(H,35,41)(H,36,45)(H,49,50)(H,51,52)(H2,34,37,38)(H2,46,47,48)/p-4/b9-8-/t22-,26+,27+,28u,32-/m0/s1 EHMN_ABBREVIATION: CE4794

metaM dadp m
boundary condition: false
notes: FORMULA: C10H12N5O9P2 CHARGE: -3 INCHI: InChI=1S/C10H15N5O9P2/c11-9-8-10(13-3-12-9)15(4-14-8)7-1-5(16)6(23-7)2-22-26(20,21)24-25(17,18)19/h3-7,16H,1-2H2,(H,20,21)(H2,11,12,13)(H2,17,18,19)/p-3/t5-,6+,7+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00192 EHMN_ABBREVIATION: C00206
name: dADP(3-)
initial concentration: 1.0
initial amount: NaN
constant: false
has only substance units: false
is: SBO:0000247
type: Species
is: CHEBI:57667
is: HMDB01508

metaR r0331
kinetic law: MODEL1310110045#
modifier: MODEL1310110045#
is described by: ECO:0000000
product: MODEL1310110045#
reversible: false
type: Reaction
is: SBO:0000176
reactant: MODEL1310110045#
fast: false
name: 5,6-Dihydrothymine:NAD+ oxidoreductase Pyrimidine metabolism EC:1.3.1.1
notes: GENE_ASSOCIATION: (6576.1) SUBSYSTEM: Pyrimidine catabolism EC Number: 1.3.1.1 Confidence Level: 0 AUTHORS: PMID:1260500,PMID:8615641 NOTES:

metaR r0788
is version of: http://identifiers.org/ec-code/1.14.13.15
name: S-Adenosyl-L-methionine:methylethanolamine phosphate N-methyltransferase Glycerophospholipid metabolism EC:2.1.1.103
fast: false
type: Reaction
is described by: ECO:0000000
reversible: true
reactant: MODEL1310110045#
kinetic law: MODEL1310110045#
is: SBO:0000176
notes: GENE_ASSOCIATION: (1593.1) SUBSYSTEM: Sphingolipid metabolism EC Number: 2.1.1.103 Confidence Level: 0 AUTHORS: PMID:2403362 NOTES:
product: MODEL1310110045#
modifier: MODEL1310110045#

metaM xylt c
type: Species
is: SBO:0000247
name: xylitol
initial concentration: 1.0
is: HMDB02917
is: CHEBI:17151
constant: false
initial amount: NaN
notes: FORMULA: C5H12O5 CHARGE: 0 INCHI: InChI=1S/C5H12O5/c6-1-3(8)5(10)4(9)2-7/h3-10H,1-2H2/t3-,4+,5+ HEPATONET_1.0_ABBREVIATION: HC00317 EHMN_ABBREVIATION: C00379
has only substance units: false
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110045#_e5e5fe82_478a_493b_a3ba_fc724d229103
has only substance units: false
type: Species
boundary condition: true
initial concentration: NaN
constant: false
is: SBO:0000252
name: GALNT1
is: Q10472
initial amount: NaN
is encoded by: hsa:2589

metaR GALASE1ly
is version of: http://identifiers.org/ec-code/3.2.1.23
is described by: ECO:0000000
modifier: MODEL1310110045#
name: beta-galactosidase, lysosomal
product: MODEL1310110045#
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) or (5476.1) and (2720.1) SUBSYSTEM: N-glycan degradation EC Number: 3.2.1.23 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD
is version of: http://identifiers.org/ec-code/3.2.1.18
reactant: MODEL1310110045#
is version of: http://identifiers.org/ec-code/3.1.6.4
is version of: http://identifiers.org/ec-code/3.4.16.5
is: SBO:0000176
type: Reaction
kinetic law: MODEL1310110045#
fast: false
reversible: false

metaR r2534
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:10049700,PMID:10574970,PMID:11389679,PMID:11557028,PMID:11564694,PMID:12824232,PMID:12930836,PMID:14574404,PMID:16288981,PMID:911815 NOTES:
reactant: MODEL1310110045#
kinetic law: MODEL1310110045#
is described by: ECO:0000000
type: Reaction
reversible: true
name: Major Facilitator(MFS) TCDB:2.A.1.44.1
is: SBO:0000185
product: MODEL1310110045#
fast: false

metaR r1418
is: SBO:0000176
reactant: MODEL1310110045#
type: Reaction
kinetic law: MODEL1310110045#
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 4.2.1.1 Confidence Level: 0 AUTHORS: PMID:10938543,PMID:11493685,PMID:12713833,PMID:12747791,PMID:14640555,PMID:17259996,PMID:17504134,PMID:17826101,PMID:7011879,PMID:7672338 NOTES:
product: MODEL1310110045#
fast: false
is described by: ECO:0000000
name: Carbonic acid hydro-lyase Nitrogen metabolism EC:4.2.1.1

metaM citr L m
type: Species
boundary condition: false
is: SBO:0000247
is: HMDB00904
notes: FORMULA: C6H13N3O3 CHARGE: 0 INCHI: InChI=1S/C6H13N3O3/c7-4(5(10)11)2-1-3-9-6(8)12/h4H,1-3,7H2,(H,10,11)(H3,8,9,12)/t4-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00277
initial concentration: 1.0
is: CHEBI:16349
constant: false
has only substance units: false
initial amount: NaN
name: L-citrulline

http://identifiers.org/biomodels.db/MODEL1310110045#_a6ff56e8_38f6_4a8a_ae89_1a3d86728273
initial amount: NaN
is: SBO:0000252
is encoded by: hsa:23600
boundary condition: true
name: AMACR
has only substance units: false
is: Q3KT79
initial concentration: NaN
type: Species
constant: false

metaM thymd c
name: Thymidine
is: SBO:0000247
is: HMDB00273
is: CHEBI:17748
initial amount: NaN
type: Species
boundary condition: false
has only substance units: false
initial concentration: 1.0
notes: FORMULA: C10H14N2O5 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00198 EHMN_ABBREVIATION: C00214
is: C00214
constant: false

metaR r0789
reactant: MODEL1310110045#
product: MODEL1310110045#
fast: false
reversible: true
type: Reaction
kinetic law: MODEL1310110045#
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/1.14.13.15
is: SBO:0000176
name: S-Adenosyl-L-methionine:phosphodimethylethanolamine N-methyltransferase Glycerophospholipid metabolism EC:2.1.1.103
modifier: MODEL1310110045#
notes: GENE_ASSOCIATION: (1593.1) SUBSYSTEM: Sphingolipid metabolism EC Number: 2.1.1.103 Confidence Level: 0 AUTHORS: PMID:2403362 NOTES:

metaR ACACT10m
is version of: http://identifiers.org/ec-code/2.3.1.9
product: MODEL1310110045#
fast: false
notes: GENE_ASSOCIATION: (38.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 2.3.1.9 Confidence Level: 4 AUTHORS: PMID:676035 NOTES:MM. 2-Methyl-3-acetoacetyl-CoA excreted into urine for patients with disease deficiency
kinetic law: MODEL1310110045#
is: SBO:0000176
reactant: MODEL1310110045#
type: Reaction
name: acetyl-CoA C-acetyltransferase, mitochondrial
reversible: true
modifier: MODEL1310110045#
is described by: ECO:0000134

metaR RE3556C
type: Reaction
fast: false
reversible: true
is: SBO:0000176
reactant: MODEL1310110045#
name: RE3556
product: MODEL1310110045#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Eicosanoid metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:234423 NOTES:
kinetic law: MODEL1310110045#

http://identifiers.org/biomodels.db/MODEL1310110045#_f1978cda_e8ed_40ee_9f32_fa89d4f2a212
initial amount: NaN
constant: false
is encoded by: hsa:2530
has only substance units: false
name: FUT8
type: Species
is: G3V5N0
initial concentration: NaN
boundary condition: true
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110045#_878c7366_1ae3_42d8_a67d_6e391a9d596f
initial amount: NaN
has only substance units: false
is: SBO:0000252
initial concentration: NaN
boundary condition: true
type: Species
is encoded by: hsa:1841
is: P23919
constant: false
name: DTYMK

http://identifiers.org/biomodels.db/MODEL1310110045#_855ffc68_d46e_4016_8bb8_8dd4c4982a63
initial concentration: NaN
boundary condition: true
name: _AI222095_1_m
initial amount: NaN
is encoded by: hsa:AI222095
type: Species
constant: false
has only substance units: false
is: SBO:0000252

metaM prostge2 c
type: Species
has only substance units: false
boundary condition: false
is: SBO:0000247
constant: false
notes: FORMULA: C20H31O5 CHARGE: -1 INCHI: InChI=1S/C20H32O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h4,7,12-13,15-17,19,21,23H,2-3,5-6,8-11,14H2,1H3,(H,24,25)/p-1/b7-4-,13-12+/t15-,16+,17+,19+/m0/s1 EHMN_ABBREVIATION: C00584
is: CHEBI:606564
initial concentration: 1.0
name: prostaglandin E2(1-)
initial amount: NaN
is: HMDB01220

metaR r2535
is described by: ECO:0000000
type: Reaction
reversible: true
is: SBO:0000185
product: MODEL1310110045#
fast: false
name: Major Facilitator(MFS) TCDB:2.A.1.44.1
reactant: MODEL1310110045#
kinetic law: MODEL1310110045#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:10049700,PMID:10574970,PMID:11389679,PMID:11557028,PMID:11564694,PMID:12824232,PMID:12930836,PMID:14574404,PMID:16288981,PMID:911815 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110045#_9ab6e668_5f2e_45a3_90fc_008a306b28a6
is encoded by: hsa:23517
initial amount: NaN
initial concentration: NaN
has only substance units: false
type: Species
is: Q3MHC9
constant: false
is: SBO:0000252
name: SKIV2L2
boundary condition: true

metaM xylt e
name: xylitol
initial concentration: 1.0
is: SBO:0000247
initial amount: NaN
type: Species
has only substance units: false
is: HMDB02917
boundary condition: false
notes: FORMULA: C5H12O5 CHARGE: 0 INCHI: InChI=1S/C5H12O5/c6-1-3(8)5(10)4(9)2-7/h3-10H,1-2H2/t3-,4+,5+ HEPATONET_1.0_ABBREVIATION: HC00317 EHMN_ABBREVIATION: C00379
is: CHEBI:17151
constant: false

metaR C40CPT1
kinetic law: MODEL1310110045#
product: MODEL1310110045#
reactant: MODEL1310110045#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: production of butyrylcarnitine
type: Reaction

metaM galside hs g
is: CHEBI:12947
name: D-galactosyl-N-acylsphingosine
initial amount: NaN
constant: false
type: Species
has only substance units: false
boundary condition: false
is: SBO:0000247
initial concentration: 1.0
notes: FORMULA: C24H46NO7FULLRCO CHARGE: 0 EHMN_ABBREVIATION: C02686

metaM mhista c
notes: FORMULA: C6H12N3 CHARGE: 1 INCHI: InChI=1S/C6H11N3/c1-9-4-6(2-3-7)8-5-9/h4-5H,2-3,7H2,1H3/p+1 EHMN_ABBREVIATION: C05127
is: HMDB00898
boundary condition: false
initial concentration: 1.0
type: Species
has only substance units: false
is: CHEBI:58600
initial amount: NaN
constant: false
name: N(tele)-methylhistaminium
is: SBO:0000247

metaR RE2304E
product: MODEL1310110045#
is described by: ECO:0000000
type: Reaction
kinetic law: MODEL1310110045#
is: SBO:0000176
reactant: MODEL1310110045#
is version of: http://identifiers.org/ec-code/3.4.21.59
fast: false
notes: GENE_ASSOCIATION: (7177.1) or (64499.1) or (23430.1) SUBSYSTEM: Miscellaneous EC Number: 3.4.21.59 Confidence Level: 0 AUTHORS: PMID:1800960 NOTES:
reversible: true
name: RE2304
modifier: MODEL1310110045#

metaM ksii core4 pre5 g
name: keratan sulfate II biosynthesis, precursor 5
is: C00130
is: HMDB00175
constant: false
notes: FORMULA: C69H112N6O48X CHARGE: -1
is: CHEBI:58053
initial amount: NaN
boundary condition: false
is: SBO:0000247
has only substance units: false
initial concentration: 1.0
type: Species

metaR EX lac L LPAREN e RPAREN
kinetic law: MODEL1310110045#
reactant: MODEL1310110045#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: L-Lactate exchange
type: Reaction

metaM thymd e
is: SBO:0000247
initial amount: NaN
is: HMDB00273
is: CHEBI:17748
name: Thymidine
type: Species
boundary condition: false
is: C00214
constant: false
has only substance units: false
initial concentration: 1.0
notes: FORMULA: C10H14N2O5 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00198 EHMN_ABBREVIATION: C00214

http://identifiers.org/biomodels.db/MODEL1310110045#_5c947bba_d2cd_4ee4_8a1a_a2580bf58122
initial concentration: NaN
initial amount: NaN
is: A0PJK1
constant: false
type: Species
boundary condition: true
is encoded by: hsa:125206
has only substance units: false
name: SLC5A10
is: SBO:0000252

metaR 3MLDAt
reactant: MODEL1310110045#
is: SBO:0000185
is described by: ECO:0000000
fast: false
product: MODEL1310110045#
name: 3MLDA extracellular transport via diffusion
reversible: true
kinetic law: MODEL1310110045#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11411609 NOTES:SAB
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110045#_68dc3630_50d4_4a0c_a782_c62844dd8aee
is: SBO:0000252
name: LDHC
initial amount: NaN
has only substance units: false
is encoded by: hsa:3948
constant: false
boundary condition: true
is: P07864
initial concentration: NaN
type: Species

metaM hdca c
name: palmitate
is: CHEBI:7896
type: Species
is: HMDB00220
initial amount: NaN
constant: false
is: SBO:0000247
has only substance units: false
notes: FORMULA: C16H31O2 CHARGE: -1 INCHI: InChI=1S/C16H32O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16(17)18/h2-15H2,1H3,(H,17,18)/p-1 HEPATONET_1.0_ABBREVIATION: HC00226 EHMN_ABBREVIATION: C00249
initial concentration: 1.0
boundary condition: false

metaR r0480
kinetic law: MODEL1310110045#
product: MODEL1310110045#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Glycerophospholipid metabolism EC Number: 2.1.1.103 Confidence Level: 0 AUTHORS: PMID:2403362 NOTES:
type: Reaction
reversible: true
name: S-Adenosyl-L-methionine:ethanolamine-phosphate N-methyltransferase Glycerophospholipid metabolism EC:2.1.1.103
is described by: ECO:0000000
is: SBO:0000176
reactant: MODEL1310110045#

metaR NACHEXA17ly
fast: false
is version of: http://identifiers.org/ec-code/3.2.1.52
notes: GENE_ASSOCIATION: (3073.1) or (3073.1 and 3074.1) SUBSYSTEM: Keratan sulfate degradation EC Number: Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12706724,PMID:8993162 NOTES:Note that this reaction is specific to beta-N-acetylhexosaminidase A and cannot be catalyzed by beta-N-acetylhexosaminidase B (or presumably beta-N-acetylhexosaminidase S). This is also a lumped reaction, representing the cleavage of GalNAc4S or GalNAc6S and N-acetylgalactosamine 4-sulfatase or 6-sulfatase. NCD
reactant: MODEL1310110045#
reversible: false
product: MODEL1310110045#
kinetic law: MODEL1310110045#
modifier: MODEL1310110045#
type: Reaction
is described by: ECO:0000000
name: beta-N-acetylhexosaminidase A, lysosomal
is: SBO:0000176

metaR L LACt2r
type: Reaction
notes: GENE_ASSOCIATION: (9194.1) or (23539.1) or (6566.1) or (9123.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10493836,PMID:10510291,PMID:11101640,PMID:11827462,PMID:12739169,PMID:7835905,PMID:8476015,PMID:9425115,PMID:9508842,PMID:9649795,PMID:9786900,PMID:9824713 NOTES:NCD
product: MODEL1310110045#
reversible: true
modifier: MODEL1310110045#
kinetic law: MODEL1310110045#
is described by: ECO:0000269
fast: false
is: SBO:0000185
reactant: MODEL1310110045#
name: L-lactate reversible transport via proton symport

metaR r2537
is: SBO:0000185
reversible: true
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:10049700,PMID:10574970,PMID:11389679,PMID:11557028,PMID:11564694,PMID:12824232,PMID:12930836,PMID:14574404,PMID:16288981,PMID:911815 NOTES:
product: MODEL1310110045#
name: Utilized transport
reactant: MODEL1310110045#
kinetic law: MODEL1310110045#
is described by: ECO:0000000
type: Reaction

metaM tsul m
is: HMDB00257
is: SBO:0000247
initial concentration: 1.0
initial amount: NaN
name: thiosulfate(2-)
constant: false
notes: FORMULA: O3S2 CHARGE: -2 INCHI: InChI=1S/H2O3S2/c1-5(2,3)4/h(H2,1,2,3,4)/p-2 EHMN_ABBREVIATION: C00320
type: Species
boundary condition: false
has only substance units: false
is: CHEBI:16094

metaR GLYCTO1p
is: SBO:0000176
type: Reaction
notes: GENE_ASSOCIATION: (51179.1) or (54363.1) or (51179.2) SUBSYSTEM: Glyoxylate and dicarboxylate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:10777549,PMID:4705431,PMID:9038835 NOTES:tv NCD
modifier: MODEL1310110045#
fast: false
product: MODEL1310110045#
is described by: ECO:0000269
reactant: MODEL1310110045#
reversible: false
name: Glycolate oxidase, peroxisome
kinetic law: MODEL1310110045#
is version of: http://identifiers.org/ec-code/1.1.3.15

metaR EX adrn LPAREN e RPAREN
kinetic law: MODEL1310110045#
reactant: MODEL1310110045#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: adrenic acid exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110045#_2097cd8c_3bee_4bcd_9344_c9c02f148fc5
initial amount: NaN
initial concentration: NaN
is: Q9UPY5
constant: false
name: SLC7A11
boundary condition: true
is: SBO:0000252
is encoded by: hsa:23657
has only substance units: false
type: Species

metaR FAOXC164C165m
kinetic law: MODEL1310110045#
product: MODEL1310110045#
reactant: MODEL1310110045#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C16:4-->C16:5)m
type: Reaction

metaR UAGALDP
fast: false
kinetic law: MODEL1310110045#
type: Reaction
is: SBO:0000176
product: MODEL1310110045#
reactant: MODEL1310110045#
reversible: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Aminosugar metabolism EC Number: Confidence Level: 2 AUTHORS: NOTES:NCD
name: UDP-N-acetylgalactosamine diphosphorylase
is described by: ECO:0000000

metaR AG13T8g
is version of: http://identifiers.org/ec-code/2.4.1.149
is described by: ECO:0000000
reactant: MODEL1310110045#
reversible: false
type: Reaction
is: SBO:0000176
kinetic law: MODEL1310110045#
notes: GENE_ASSOCIATION: (79369.1) or (374907.1) or (11041.1) or (146712.1) or (374907.2) or (93010.1) or (10331.1) or (10678.1) or (10678.2) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.149 Confidence Level: 4 AUTHORS: PMID:10747980,PMID:11042166,PMID:12061784,PMID:12512857,PMID:15560372,PMID:15620693,PMID:9405606 NOTES:NCD
name: N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase, Golgi apparatus
product: MODEL1310110045#
modifier: MODEL1310110045#
fast: false

metaR GNDer
is: SBO:0000176
reactant: MODEL1310110045#
name: phosphogluconate dehydrogenase, endoplasmic reticulum
product: MODEL1310110045#
notes: GENE_ASSOCIATION: SUBSYSTEM: Pentose phosphate pathway EC Number: 1.1.1.44 Confidence Level: 4 AUTHORS: PMID:2156506 NOTES:SMP Note no proton generation by the the reaction NCD
fast: false
type: Reaction
reversible: false
is described by: ECO:0000000
kinetic law: MODEL1310110045#

http://identifiers.org/biomodels.db/MODEL1310110045#_897f9159_4412_4131_b9c5_7eb6db50d488
type: Species
has only substance units: false
is: SBO:0000252
boundary condition: true
constant: false
is encoded by: hsa:2348
name: FOLR1
initial concentration: NaN
initial amount: NaN

metaR CGLYt3 2
name: Cys-Gly transport in via proton symport
modifier: MODEL1310110045#
is described by: ECO:0000304
is: SBO:0000185
reversible: false
reactant: MODEL1310110045#
notes: GENE_ASSOCIATION: (6565.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:12905028 NOTES:SAB
type: Reaction
product: MODEL1310110045#
fast: false
kinetic law: MODEL1310110045#

metaR EX o2 LPAREN e RPAREN
kinetic law: MODEL1310110045#
reactant: MODEL1310110045#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for oxugen
type: Reaction

metaR CYSGLYexR
reversible: true
is described by: ECO:0000000
modifier: MODEL1310110045#
product: MODEL1310110045#
notes: GENE_ASSOCIATION: (6520.1) and (23428.1) or (6520.1) and (23428.2) or (56301.1) and (6520.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10734121,PMID:10863037,PMID:14770310 NOTES:Merged CYSGLYexR and CYSGLYex - (May 2011) IT
reactant: MODEL1310110045#
name: L-cysteine/glycine reversible exchanger
type: Reaction
is: SBO:0000185
kinetic law: MODEL1310110045#
fast: false

metaM na1 c
notes: FORMULA: Na CHARGE: 1
is: C01330
initial amount: NaN
type: Species
boundary condition: false
initial concentration: 1.0
is: SBO:0000247
is: CHEBI:4541
has only substance units: false
is: HMDB00588
name: Sodium
constant: false

http://identifiers.org/biomodels.db/MODEL1310110045#_df0615bb_9e34_41cc_a917_87f221963104
is encoded by: hsa:2629
initial amount: NaN
name: GBA
constant: false
type: Species
has only substance units: false
is: SBO:0000252
boundary condition: true
initial concentration: NaN

metaM ksii core2 pre6 g
is: SBO:0000247
initial amount: NaN
type: Species
is: CHEBI:28067
name: keratan sulfate II biosynthesis, precursor 6
boundary condition: false
initial concentration: 1.0
constant: false
has only substance units: false
notes: FORMULA: C61H98N5O46SX CHARGE: -2

metaR INSTt4
kinetic law: MODEL1310110045#
is described by: ECO:0000269
reversible: true
product: MODEL1310110045#
modifier: MODEL1310110045#
fast: false
reactant: MODEL1310110045#
notes: GENE_ASSOCIATION: (6526.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12748858,PMID:1372904,PMID:15546855,PMID:7537337,PMID:7789985 NOTES:NCD
type: Reaction
name: inositol transport via sodium symport
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110045#_dedef3a8_31ce_494a_a240_411cf967b789
is: SBO:0000252
boundary condition: true
has only substance units: false
name: LDHA
initial concentration: NaN
is encoded by: hsa:3939
initial amount: NaN
type: Species
constant: false
is: P00338

http://identifiers.org/biomodels.db/MODEL1310110045#_bb38814b_e0eb_4517_89e1_0f71265983ae
has only substance units: false
initial amount: NaN
constant: false
boundary condition: true
is encoded by: hsa:2936
is: P00390
initial concentration: NaN
type: Species
name: GSR
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110045#_a996f0bb_4ec3_4fa7_8117_bd4a14c825e0
has only substance units: false
initial concentration: NaN
initial amount: NaN
has part: Q8WYR1
constant: false
boundary condition: true
name: PIK3R5:PIK3CG
type: Species
is encoded by: hsa:23533
is: SBO:0000297

metaR DASPO1p
notes: GENE_ASSOCIATION: (8528.2) or (8528.1) SUBSYSTEM: Alanine and aspartate metabolism EC Number: 1.4.3.1 Confidence Level: 4 AUTHORS: PMID:12209855,PMID:9820813 NOTES:MM
product: MODEL1310110045#
reversible: false
reactant: MODEL1310110045#
is: SBO:0000176
is described by: ECO:0000269
name: D-aspartate oxidase, peroxisomal
fast: false
modifier: MODEL1310110045#
kinetic law: MODEL1310110045#
is version of: http://identifiers.org/ec-code/1.4.3.1
type: Reaction

metaR MDHm
reversible: true
product: MODEL1310110045#
is described by: ECO:0000134
modifier: MODEL1310110045#
fast: false
name: malate dehydrogenase, mitochondrial
notes: GENE_ASSOCIATION: (4191.1) SUBSYSTEM: Citric acid cycle EC Number: 1.1.1.37 Confidence Level: 0 AUTHORS: PMID:15565635,PMID:9933076 NOTES:IF. Biochemical
is: SBO:0000176
kinetic law: MODEL1310110045#
type: Reaction
is version of: http://identifiers.org/ec-code/1.1.1.37
reactant: MODEL1310110045#

metaM prostgi2 e
initial concentration: 1.0
name: prostaglandin I2(1-)
boundary condition: false
has only substance units: false
is: CHEBI:57403
is: SBO:0000247
constant: false
notes: FORMULA: C20H31O5 CHARGE: -1 INCHI: InChI=1S/C20H32O5/c1-2-3-4-7-14(21)10-11-16-17-12-15(8-5-6-9-20(23)24)25-19(17)13-18(16)22/h8,10-11,14,16-19,21-22H,2-7,9,12-13H2,1H3,(H,23,24)/p-1/b11-10+,15-8-/t14-,16+,17+,18+,19-/m0/s1 EHMN_ABBREVIATION: C01312
type: Species
is: HMDB01335
initial amount: NaN

metaR NH4t3r
reactant: MODEL1310110045#
kinetic law: MODEL1310110045#
reversible: true
fast: false
product: MODEL1310110045#
modifier: MODEL1310110045#
is: SBO:0000185
notes: GENE_ASSOCIATION: (57127.1) or (6005.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10444453,PMID:11024028,PMID:12920597,PMID:1417776,PMID:14966114,PMID:15284342,PMID:8595899 NOTES:
type: Reaction
name: ammonia transport via proton antiport
is described by: ECO:0000269

metaM pro L e
boundary condition: false
initial concentration: 1.0
is: HMDB00162
initial amount: NaN
is: CHEBI:17203
type: Species
notes: FORMULA: C5H9NO2 CHARGE: 0 INCHI: InChI=1S/C5H9NO2/c7-5(8)4-2-1-3-6-4/h4,6H,1-3H2,(H,7,8)/t4-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00145
has only substance units: false
is: SBO:0000247
name: L-proline
constant: false

metaR EX dcyt LPAREN e RPAREN
kinetic law: MODEL1310110045#
reactant: MODEL1310110045#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for Deoxycytidine
type: Reaction

metaR r0033
name: ATP:dephospho-CoA 3-phosphotransferase Pantothenate and CoA biosynthesis EC:2.7.1.24
product: MODEL1310110045#
modifier: MODEL1310110045#
is version of: http://identifiers.org/ec-code/3.6.1.5
type: Reaction
is: SBO:0000176
reversible: false
fast: false
reactant: MODEL1310110045#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (AV717590.1) or (953.1) or (956.1) or (377841.1) SUBSYSTEM: CoA synthesis EC Number: 2.7.1.24 Confidence Level: 0 AUTHORS: PMID:11923312,PMID:11994049,PMID:13163064,PMID:15893380 NOTES:
kinetic law: MODEL1310110045#

http://identifiers.org/biomodels.db/MODEL1310110045#_a0678329_cf4b_45ea_b208_9063f4461929
is encoded by: hsa:5139
type: Species
has only substance units: false
initial concentration: NaN
initial amount: NaN
is: Q14432
constant: false
name: PDE3A
boundary condition: true
is: SBO:0000252

metaR PNTEH
reversible: false
is version of: http://identifiers.org/ec-code/3.5.1.92
modifier: MODEL1310110045#
name: Hydrolase Class ( RXN R02973)
notes: GENE_ASSOCIATION: (8876.1) and (8875.2) and (55350.3) or (8876.1) and (8875.2) and (55350.2) or (8876.1) and (8875.1) and (55350.1) or (8876.1) and (55350.2) and (8875.1) or (8875.2) and (8876.1) and (55350.1) or (8876.1) and (55350.3) and (8875.1) SUBSYSTEM: CoA catabolism EC Number: Confidence Level: 4 AUTHORS: PMID:10567687,PMID:11491533 NOTES:EC 3.5.1- KEGG RXN R02973 RM
type: Reaction
product: MODEL1310110045#
is: SBO:0000176
reactant: MODEL1310110045#
is described by: ECO:0000269
fast: false
kinetic law: MODEL1310110045#

metaM m5masnB2 g
is: CHEBI:58282
constant: false
initial concentration: 1.0
initial amount: NaN
type: Species
notes: FORMULA: C52H87N2O40X CHARGE: 0
is: SBO:0000247
boundary condition: false
is: HMDB00968
has only substance units: false
name: (alpha-D-mannosyl)5-beta-D-mannosyl-diacetylchitobiosyl-L-asparagine (protein)

http://identifiers.org/biomodels.db/MODEL1310110045#_ed06a24d_078d_440e_8fcb_7a5168571de4
has part: P16278
has part: Q99519
name: GALNS:GLB1:NEU1:CTSA
type: Species
has only substance units: false
is encoded by: hsa:2588
has part: P34059
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:4758
has part: P10619
is encoded by: hsa:2720
is: SBO:0000297
boundary condition: true
constant: false
is encoded by: hsa:5476

metaM 13dpg c
boundary condition: false
is: HMDB01270
initial amount: NaN
is: SBO:0000247
notes: FORMULA: C3H4O10P2 CHARGE: -4 INCHI: 1/C3H8O10P2/c4-2(1-12-14(6,7)8)3(5)13-15(9,10)11/h2,4H,1H2,(H2,6,7,8)(H2,9,10,11)/t2-/m1/s1/f/h6-7,9-10H HEPATONET_1.0_ABBREVIATION: HC00214 EHMN_ABBREVIATION: C00236
is: http://identifiers.org/pubchem.compound/3535
constant: false
is: CHEBI:57604
type: Species
has only substance units: false
is: C00236
name: 3-Phospho-D-glyceroyl phosphate
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110045#_aef42d70_198d_4e75_8dc5_bb7d388c2eb0
constant: false
initial concentration: NaN
type: Species
is: P30838
is: SBO:0000252
is encoded by: hsa:218
has only substance units: false
name: ALDH3A1
boundary condition: true
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110045#_58a74bf0_20db_411d_a5cf_f8d10c82db80
constant: false
name: AK1
initial concentration: NaN
is: SBO:0000252
boundary condition: true
is: P00568
has only substance units: false
initial amount: NaN
type: Species
is encoded by: hsa:203

http://identifiers.org/biomodels.db/MODEL1310110045#_5847440e_c4eb_4921_953e_17f030cec979
initial concentration: NaN
is: SBO:0000252
type: Species
initial amount: NaN
is encoded by: hsa:4514
constant: false
boundary condition: true
has only substance units: false
name: COX3
is: P00414

metaM prostgi2 c
initial amount: NaN
is: HMDB01335
is: CHEBI:57403
initial concentration: 1.0
constant: false
notes: FORMULA: C20H31O5 CHARGE: -1 INCHI: InChI=1S/C20H32O5/c1-2-3-4-7-14(21)10-11-16-17-12-15(8-5-6-9-20(23)24)25-19(17)13-18(16)22/h8,10-11,14,16-19,21-22H,2-7,9,12-13H2,1H3,(H,23,24)/p-1/b11-10+,15-8-/t14-,16+,17+,18+,19-/m0/s1 EHMN_ABBREVIATION: C01312
name: prostaglandin I2(1-)
type: Species
boundary condition: false
has only substance units: false
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110045#_9fffb1a8_2db7_4fdd_b216_0fb500ad6618
initial amount: NaN
name: _AA532636_1_m
has only substance units: false
is encoded by: hsa:AA532636
initial concentration: NaN
boundary condition: true
type: Species
is: SBO:0000252
constant: false

metaR EX 5mta LPAREN e RPAREN
kinetic law: MODEL1310110045#
reactant: MODEL1310110045#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: Exchange of 5-S-methyl-5-thioadenosine
type: Reaction

metaM 3mop c
initial amount: NaN
initial concentration: 1.0
constant: false
has only substance units: false
boundary condition: false
notes: FORMULA: C6H9O3 CHARGE: -1 INCHI: InChI=1S/C6H10O3/c1-3-4(2)5(7)6(8)9/h4H,3H2,1-2H3,(H,8,9)/p-1 HEPATONET_1.0_ABBREVIATION: HC01123 EHMN_ABBREVIATION: C00671
type: Species
is: HMDB00491
is: SBO:0000247
is: CHEBI:28654
name: 3-methyl-2-oxopentanoate

http://identifiers.org/biomodels.db/MODEL1310110045#_9e871de1_ecbf_4d31_a15d_63876072aed3
type: Species
initial amount: NaN
constant: false
has only substance units: false
is: SBO:0000252
name: _NOS2A_1_c
boundary condition: true
initial concentration: NaN
is encoded by: hsa:NOS2A

http://identifiers.org/biomodels.db/MODEL1310110045#_c9fc9353_8521_4b35_8e87_acc698cb90b3
initial amount: NaN
has only substance units: false
initial concentration: NaN
type: Species
constant: false
is: B2RB13
is encoded by: hsa:23305
name: ACSL6
is: SBO:0000252
boundary condition: true

metaR CO2t
product: MODEL1310110045#
reactant: MODEL1310110045#
is described by: ECO:0000000
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 1 AUTHORS: NOTES:tv renamed from CO2TPr to CO2t NCD
name: CO2 transporter via diffusion
fast: false
reversible: true
is: SBO:0000185
kinetic law: MODEL1310110045#

http://identifiers.org/biomodels.db/MODEL1310110045#_09686ef8_85b2_4c03_b9ac_e7eb3847e644
is encoded by: hsa:3157
boundary condition: true
has only substance units: false
is: SBO:0000252
initial amount: NaN
constant: false
name: HMGCS1
is: Q01581
type: Species
initial concentration: NaN

metaM lgnc c
type: Species
is: SBO:0000247
initial concentration: 1.0
boundary condition: false
notes: FORMULA: C24H47O2 CHARGE: -1 INCHI: InChI=1S/C24H48O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-24(25)26/h2-23H2,1H3,(H,25,26)/p-1 HEPATONET_1.0_ABBREVIATION: HC01788 EHMN_ABBREVIATION: CE2547
has only substance units: false
initial amount: NaN
is: CHEBI:31014
constant: false
is: HMDB02003
name: lignocerate

metaM dttp e
notes: FORMULA: C10H13N2O14P3 CHARGE: -4 INCHI: InChI=1S/C10H17N2O14P3/c1-5-3-12(10(15)11-9(5)14)8-2-6(13)7(24-8)4-23-28(19,20)26-29(21,22)25-27(16,17)18/h3,6-8,13H,2,4H2,1H3,(H,19,20)(H,21,22)(H,11,14,15)(H2,16,17,18)/p-4/t6-,7+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00368 EHMN_ABBREVIATION: C00459
name: dTTP(4-)
constant: false
boundary condition: false
type: Species
is: SBO:0000247
initial concentration: 1.0
is: CHEBI:37568
is: HMDB01342
has only substance units: false
initial amount: NaN

metaM h x
notes: FORMULA: H CHARGE: 1 INCHI: " HEPATONET_1.0_ABBREVIATION: HC00083 EHMN_ABBREVIATION: C00080
is: C00080
initial amount: NaN
is: CHEBI:24636
is: SBO:0000247
constant: false
boundary condition: false
type: Species
name: proton
initial concentration: 1.0
is: http://identifiers.org/pubchem.compound/3380
has only substance units: false

metaR DALAt2r
name: D-alanine transport via proton symport
reversible: true
kinetic law: MODEL1310110045#
fast: false
product: MODEL1310110045#
is: SBO:0000185
type: Reaction
reactant: MODEL1310110045#
is described by: ECO:0000304
notes: GENE_ASSOCIATION: (206358.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11390972,PMID:11959859 NOTES:JLR
modifier: MODEL1310110045#

http://identifiers.org/biomodels.db/MODEL1310110045#_238d710d_cc6a_46c8_8874_4d6b34669bfe
is: E9PDD5
boundary condition: true
type: Species
is: SBO:0000252
initial concentration: NaN
initial amount: NaN
has only substance units: false
is encoded by: hsa:3421
name: IDH3G
constant: false

metaR FAOXC16OHC16r
kinetic law: MODEL1310110045#
product: MODEL1310110045#
reactant: MODEL1310110045#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid omega oxidation(C16-->w-OHC16)er
type: Reaction

metaR LEUKTRE4t
is described by: ECO:0000000
type: Reaction
reactant: MODEL1310110045#
name: leukotriene E4 transport
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:
fast: false
kinetic law: MODEL1310110045#
reversible: true
is: SBO:0000185
product: MODEL1310110045#

metaM pail35p hs c
boundary condition: false
has only substance units: false
initial amount: NaN
name: 1-phosphatidyl-1D-myo-inositol 3,5-bisphosphate(5-)
is: CHEBI:57923
is: SBO:0000247
constant: false
initial concentration: 1.0
notes: FORMULA: C9H14O15P3FULLRCO2FULLR2CO2 CHARGE: -5
type: Species

metaM 3mop e
constant: false
name: 3-methyl-2-oxopentanoate
initial concentration: 1.0
notes: FORMULA: C6H9O3 CHARGE: -1 INCHI: InChI=1S/C6H10O3/c1-3-4(2)5(7)6(8)9/h4H,3H2,1-2H3,(H,8,9)/p-1
has only substance units: false
boundary condition: false
type: Species
is: HMDB00491
is: SBO:0000247
initial amount: NaN
is: CHEBI:28654

metaR r2397
product: MODEL1310110045#
type: Reaction
reactant: MODEL1310110045#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172 NOTES:
fast: false
is described by: ECO:0000000
kinetic law: MODEL1310110045#
reversible: false
name: Mitochondrial Carrier (MC) TCDB:2.A.29.19.1

metaR r0345
is version of: http://identifiers.org/ec-code/1.3.3.6
reversible: true
is version of: http://identifiers.org/ec-code/1.3.99.13
modifier: MODEL1310110045#
kinetic law: MODEL1310110045#
is described by: ECO:0000000
product: MODEL1310110045#
reactant: MODEL1310110045#
notes: GENE_ASSOCIATION: (27034.1) or (28976.1) or (33.1) or (34.1) or (37.1) or (51.1) or (8310.1) or (AI285872.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.11 Confidence Level: 0 AUTHORS: PMID:11768308 NOTES:
name: ATP:AMP phosphotransferase Purine metabolism EC:2.7.4.11
type: Reaction
fast: false
is version of: http://identifiers.org/ec-code/1.3.99.3
is: SBO:0000176

metaR EX chol LPAREN e RPAREN
kinetic law: MODEL1310110045#
reactant: MODEL1310110045#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for Choline
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110045#_286c221d_3ee5_4754_bf72_69e5abce62ff
name: AMPD1
type: Species
is: P23109
is: SBO:0000252
initial amount: NaN
has only substance units: false
initial concentration: NaN
boundary condition: true
constant: false
is encoded by: hsa:270

http://identifiers.org/biomodels.db/MODEL1310110045#_c0e3e562_b852_4a85_baf1_17a090f39e30
has only substance units: false
boundary condition: true
name: ACOT8
constant: false
is encoded by: hsa:10005
initial amount: NaN
type: Species
is: SBO:0000252
initial concentration: NaN
is: O14734

metaR PNTOte
reversible: true
product: MODEL1310110045#
is: SBO:0000185
kinetic law: MODEL1310110045#
type: Reaction
name: Transport of (R)-Pantothenate
fast: false
is described by: ECO:0000134
reactant: MODEL1310110045#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:

metaR EX Rtotal2 LPAREN e RPAREN
kinetic law: MODEL1310110045#
reactant: MODEL1310110045#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: R total 2 position exchange
type: Reaction

metaM na1 e
has only substance units: false
boundary condition: false
is: CHEBI:4541
notes: FORMULA: Na CHARGE: 1
type: Species
is: C01330
initial concentration: 1.0
name: Sodium
is: HMDB00588
initial amount: NaN
is: SBO:0000247
constant: false

metaM alpam m
initial amount: NaN
notes: FORMULA: C9H21N2OS2 CHARGE: 1 INCHI: InChI=1/C9H20N2OS2/c10-7-14-6-5-8(13)3-1-2-4-9(11)12/h8,13H,1-7,10H2,(H2,11,12)
initial concentration: 1.0
name: S-aminomethyldihydrolipoamide
is: SBO:0000247
boundary condition: false
type: Species
is: HMDB06239
has only substance units: false
constant: false

metaM lgnc e
type: Species
is: SBO:0000247
name: lignocerate
initial concentration: 1.0
boundary condition: false
initial amount: NaN
notes: FORMULA: C24H47O2 CHARGE: -1 INCHI: InChI=1S/C24H48O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-24(25)26/h2-23H2,1H3,(H,25,26)/p-1 HEPATONET_1.0_ABBREVIATION: HC01788 EHMN_ABBREVIATION: CE2547
constant: false
is: HMDB02003
has only substance units: false
is: CHEBI:31014

metaR DCTPtn
reactant: MODEL1310110045#
name: dCTP diffusion in nucleus
is: SBO:0000185
product: MODEL1310110045#
kinetic law: MODEL1310110045#
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: NOTES:IT
is described by: ECO:0000000
fast: false
type: Reaction

metaM ala B c
initial concentration: 1.0
type: Species
boundary condition: false
notes: FORMULA: C3H7NO2 CHARGE: 0 INCHI: InChI=1S/C3H7NO2/c4-2-1-3(5)6/h1-2,4H2,(H,5,6) HEPATONET_1.0_ABBREVIATION: HC00100
name: beta-alanine
initial amount: NaN
has only substance units: false
is: HMDB00056
is: SBO:0000247
is: CHEBI:16958
constant: false

metaM dttp c
initial amount: NaN
boundary condition: false
name: dTTP
is: C00459
constant: false
notes: FORMULA: C10H13N2O14P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00368 EHMN_ABBREVIATION: C00459
type: Species
initial concentration: 1.0
is: CHEBI:37568
is: SBO:0000247
has only substance units: false
is: HMDB01342

metaR EX nac LPAREN e RPAREN
kinetic law: MODEL1310110045#
reactant: MODEL1310110045#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Nicotinate exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110045#_d8ae7736_e8c2_4313_b484_324b4d175c8a
constant: false
type: Species
initial concentration: NaN
is: SBO:0000252
initial amount: NaN
name: _R06874_1_r
is encoded by: hsa:R06874
has only substance units: false
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110045#_7eb61f01_1f4c_4fc4_b21d_5c65c083553d
type: Species
is: SBO:0000252
has only substance units: false
initial amount: NaN
boundary condition: true
initial concentration: NaN
name: _7359_1_c
constant: false
is encoded by: hsa:7359

metaR EX lys L LPAREN e RPAREN
kinetic law: MODEL1310110045#
reactant: MODEL1310110045#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: L-Lysine exchange
type: Reaction

metaM n2m2nmasn l
initial amount: NaN
is: C04946
boundary condition: false
type: Species
is: SBO:0000247
name: N-Acetyl-beta-D-glucosaminyl-1,2-alpha-D-mannosyl-1,3-(N-acetyl-beta-D-glucosaminyl-1,2-alpha-D-mannosyl-1,6)-(N-acetyl-beta-D-glucosaminyl-1,4)-beta-D-mannosyl-1,4-N-acetyl-beta-D-glucosaminyl-R
constant: false
has only substance units: false
notes: FORMULA: C58H96N5O40X CHARGE: 0
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110045#_ec3a9aa4_7c9c_41f8_b7aa_588d13ea4fa0
boundary condition: true
is encoded by: hsa:11227
type: Species
is: A5PKZ1
is: SBO:0000252
initial concentration: NaN
constant: false
has only substance units: false
name: GALNT5
initial amount: NaN

metaM 2maacoa m
initial concentration: 1.0
constant: false
type: Species
has only substance units: false
boundary condition: false
is: HMDB01157
name: 2-methylacetoacetyl-CoA(4-)
is: SBO:0000247
notes: FORMULA: C26H38N7O18P3S CHARGE: -4 INCHI: InChI=1S/C26H42N7O18P3S/c1-13(14(2)34)25(39)55-8-7-28-16(35)5-6-29-23(38)20(37)26(3,4)10-48-54(45,46)51-53(43,44)47-9-15-19(50-52(40,41)42)18(36)24(49-15)33-12-32-17-21(27)30-11-31-22(17)33/h11-13,15,18-20,24,36-37H,5-10H2,1-4H3,(H,28,35)(H,29,38)(H,43,44)(H,45,46)(H2,27,30,31)(H2,40,41,42)/p-4/t13?,15-,18-,19-,20+,24-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01101 EHMN_ABBREVIATION: C03344
initial amount: NaN
is: CHEBI:57335

metaR TAGt
reactant: MODEL1310110045#
reversible: true
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:
type: Reaction
kinetic law: MODEL1310110045#
is: SBO:0000185
fast: false
name: triacylglycerol transport
product: MODEL1310110045#

http://identifiers.org/biomodels.db/MODEL1310110045#_6af99204_a255_43d3_be0d_1c866de7fc8b
boundary condition: true
initial amount: NaN
is: F6KD01
has only substance units: false
name: PTEN
is encoded by: hsa:5728
is: SBO:0000252
constant: false
type: Species
initial concentration: NaN

metaR RNDR4
is: SBO:0000176
reversible: false
modifier: MODEL1310110045#
type: Reaction
name: ribonucleoside-diphosphate reductase (UDP)
kinetic law: MODEL1310110045#
notes: GENE_ASSOCIATION: (6240.1 and 6241.1) SUBSYSTEM: Nucleotide interconversion EC Number: 1.7.14.1 Confidence Level: 2 AUTHORS: PMID:14729598 NOTES:
is described by: ECO:0000254
product: MODEL1310110045#
reactant: MODEL1310110045#
is version of: http://identifiers.org/ec-code/1.17.4.1
fast: false

metaR EX HC01610 LPAREN e RPAREN
kinetic law: MODEL1310110045#
reactant: MODEL1310110045#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of CoproporphyrinogenI
type: Reaction

metaM leuleu c
boundary condition: false
notes: FORMULA: C12H24N2O3 CHARGE: 0
name: Leucylleucine
initial amount: NaN
type: Species
constant: false
initial concentration: 1.0
is: SBO:0000247
is: http://identifiers.org/pubchem.compound/94244
has only substance units: false

metaM dcsptn1coa c
is: http://identifiers.org/pubchem.compound/47205483
notes: FORMULA: C43H64N7O17P3S CHARGE: -4 INCHI: InChI=1/C43H68N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-34(52)71-27-26-45-33(51)24-25-46-41(55)38(54)43(2,3)29-64-70(61,62)67-69(59,60)63-28-32-37(66-68(56,57)58)36(53)42(65-32)50-31-49-35-39(44)47-30-48-40(35)50/h8-9,11-12,14-15,17-18,20-21,30-32,36-38,42,53-54H,4-7,10,13,16,19,22-29H2,1-3H3,(H,45,51)(H,46,55)(H,59,60)(H,61,62)(H2,44,47,48)(H2,56,57,58)/b9-8-,12-11-,15-14-,18-17-,21-20-/t32-,36-,37?,38+,42-/m1/s1
is: SBO:0000247
has only substance units: false
is: C16173
type: Species
initial amount: NaN
initial concentration: 1.0
is: HMDB06513
boundary condition: false
name: docosa-4,7,10,13,16-pentaenoyl coenzyme A
constant: false

http://identifiers.org/biomodels.db/MODEL1310110045#_822da16a_307f_4e72_a23d_286430a70d36
initial concentration: NaN
name: DPAGT1
type: Species
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:1798
constant: false
has only substance units: false
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110045#_34db06bd_40f3_4d58_996c_a8dfc8b2bd5d
is encoded by: hsa:9023
constant: false
is: O95992
type: Species
has only substance units: false
is: SBO:0000252
boundary condition: true
initial concentration: NaN
initial amount: NaN
name: CH25H

http://identifiers.org/biomodels.db/MODEL1310110045#_fd66553f_bd30_4fd2_8dd9_dc9522c95654
type: Species
name: ETFA:ETFB
constant: false
has only substance units: false
initial amount: NaN
initial concentration: NaN
has part: P38117
boundary condition: true
is: SBO:0000297
is encoded by: hsa:2109

metaM nac c
notes: FORMULA: C6H4NO2 CHARGE: -1
is: C00253
boundary condition: false
name: Nicotinate
is: CHEBI:0
initial concentration: 1.0
initial amount: NaN
is: HMDB01488
type: Species
has only substance units: false
is: SBO:0000247
constant: false

metaR r1573
is: SBO:0000185
reversible: true
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
kinetic law: MODEL1310110045#
fast: false
is described by: ECO:0000000
reactant: MODEL1310110045#
product: MODEL1310110045#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1

metaM retn c
initial amount: NaN
is: CHEBI:35291
is: SBO:0000247
is: HMDB01852
notes: FORMULA: C20H27O2 CHARGE: -1 INCHI: InChI=1S/C20H28O2/c1-15(8-6-9-16(2)14-19(21)22)11-12-18-17(3)10-7-13-20(18,4)5/h6,8-9,11-12,14H,7,10,13H2,1-5H3,(H,21,22)/p-1/b9-6+,12-11+,15-8+,16-14+ HEPATONET_1.0_ABBREVIATION: HC00532 EHMN_ABBREVIATION: C00777
constant: false
has only substance units: false
name: all-trans-retinoate
boundary condition: false
initial concentration: 1.0
type: Species

metaM k e
constant: false
is: SBO:0000247
name: potassium
has only substance units: false
is: HMDB00586
initial amount: NaN
type: Species
initial concentration: 1.0
boundary condition: false
notes: FORMULA: K CHARGE: 1 HEPATONET_1.0_ABBREVIATION: HC00216 EHMN_ABBREVIATION: C00238
is: CHEBI:29103
is: C00238

metaR MANt4
is: SBO:0000185
modifier: MODEL1310110045#
kinetic law: MODEL1310110045#
type: Reaction
reactant: MODEL1310110045#
is described by: ECO:0000269
product: MODEL1310110045#
fast: false
notes: GENE_ASSOCIATION: (200010.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12748858,PMID:15607332 NOTES:NCD
name: D-mannose transport via sodium cotransport
reversible: true

metaR RNDR3
reactant: MODEL1310110045#
product: MODEL1310110045#
type: Reaction
modifier: MODEL1310110045#
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (6240.1 and 6241.1) SUBSYSTEM: Nucleotide interconversion EC Number: 1.7.14.1 Confidence Level: 4 AUTHORS: PMID:14729598 NOTES:
kinetic law: MODEL1310110045#
reversible: false
name: ribonucleoside-diphosphate reductase (CDP)
fast: false
is version of: http://identifiers.org/ec-code/1.17.4.1
is: SBO:0000176

metaM his L m
is: CHEBI:15971
boundary condition: false
has only substance units: false
name: L-histidine
is: SBO:0000247
notes: FORMULA: C6H9N3O2 CHARGE: 0 INCHI: InChI=1S/C6H9N3O2/c7-5(6(10)11)1-4-2-8-3-9-4/h2-3,5H,1,7H2,(H,8,9)(H,10,11)/t5-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00133
type: Species
initial concentration: 1.0
constant: false
is: HMDB00177
initial amount: NaN

metaR ACCOAtn
fast: false
reversible: true
is described by: ECO:0000000
product: MODEL1310110045#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD
reactant: MODEL1310110045#
kinetic law: MODEL1310110045#
is: SBO:0000185
type: Reaction
name: acetyl-CoA transport, nuclear

metaM occoa c
has only substance units: false
initial concentration: 1.0
is: C01944
constant: false
is: HMDB01070
initial amount: NaN
is: SBO:0000247
name: Octanoyl-CoA (n-C8:0CoA)
boundary condition: false
is: CHEBI:57386
type: Species
notes: FORMULA: C29H46N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00869 EHMN_ABBREVIATION: C01944

http://identifiers.org/biomodels.db/MODEL1310110045#_5a6ae382_ddd6_49d0_9fea_70506218f073
boundary condition: true
type: Species
has only substance units: false
is: SBO:0000252
initial concentration: NaN
constant: false
is: Q99714
is encoded by: hsa:3028
initial amount: NaN
name: HSD17B10

metaR r1172
type: Reaction
is described by: ECO:0000000
is: SBO:0000176
product: MODEL1310110045#
kinetic law: MODEL1310110045#
name: EC:3.1.1.13
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 3.1.1.13 Confidence Level: 0 AUTHORS: PMID:11230747,PMID:8112342 NOTES:
reactant: MODEL1310110045#
fast: false
reversible: false

metaR r1570
reactant: MODEL1310110045#
reversible: true
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
type: Reaction
kinetic law: MODEL1310110045#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
product: MODEL1310110045#
is: SBO:0000185
fast: false
is described by: ECO:0000000

metaM leuleu e
boundary condition: false
initial amount: NaN
has only substance units: false
constant: false
type: Species
notes: FORMULA: C12H24N2O3 CHARGE: 0
name: Leucylleucine
initial concentration: 1.0
is: SBO:0000247
is: http://identifiers.org/pubchem.compound/94244

http://identifiers.org/biomodels.db/MODEL1310110045#_26b21156_6d10_489d_b043_4ffd32772803
name: DGKI
has only substance units: false
initial amount: NaN
is: SBO:0000252
is encoded by: hsa:9162
boundary condition: true
is: O75912
constant: false
type: Species
initial concentration: NaN

metaR FAOXC61C4m
kinetic law: MODEL1310110045#
product: MODEL1310110045#
reactant: MODEL1310110045#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C6:1-->C4:0)m
type: Reaction

metaM hdca l
is: SBO:0000247
boundary condition: false
is: CHEBI:7896
has only substance units: false
constant: false
type: Species
notes: FORMULA: C16H31O2 CHARGE: -1 INCHI: InChI=1S/C16H32O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16(17)18/h2-15H2,1H3,(H,17,18)/p-1 HEPATONET_1.0_ABBREVIATION: HC00226 EHMN_ABBREVIATION: C00249
is: HMDB00220
name: palmitate
initial concentration: 1.0
initial amount: NaN

metaR HACD9m
modifier: MODEL1310110045#
type: Reaction
reversible: true
name: 3-hydroxyacyl-CoA dehydrogenase (2-Methylacetoacetyl-CoA), mitochondrial
fast: false
product: MODEL1310110045#
kinetic law: MODEL1310110045#
is described by: ECO:0000134
is version of: http://identifiers.org/ec-code/1.1.1.35
is: SBO:0000176
notes: GENE_ASSOCIATION: (3028.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 1.1.1.35 Confidence Level: 4 AUTHORS: PMID:12872843 NOTES:MM. inborn deficiency enzyme causes accumulation of substrate 3-hydroxy-2-methylbutyric acid
reactant: MODEL1310110045#

metaR RE3568C
name: RE3568
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Eicosanoid metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:234423 NOTES:
reversible: true
is described by: ECO:0000000
type: Reaction
fast: false
reactant: MODEL1310110045#
product: MODEL1310110045#
kinetic law: MODEL1310110045#

metaR GLYCt
fast: false
kinetic law: MODEL1310110045#
is described by: ECO:0000000
type: Reaction
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:9405233 NOTES:NCD
name: glycerol transport via channel
product: MODEL1310110045#
reactant: MODEL1310110045#
is: SBO:0000185

metaR r0196
reversible: true
modifier: MODEL1310110045#
notes: GENE_ASSOCIATION: (AV717590.1) or (953.1) or (956.1) or (377841.1) SUBSYSTEM: Unassigned EC Number: 2.3.1.37 Confidence Level: 0 AUTHORS: PMID:7592562 NOTES:
product: MODEL1310110045#
is described by: ECO:0000000
is: SBO:0000176
reactant: MODEL1310110045#
type: Reaction
is version of: http://identifiers.org/ec-code/3.6.1.5
kinetic law: MODEL1310110045#
name: Succinyl-CoA:glycine C-succinyl-transferase(decarboxylating) EC:2.3.1.37
fast: false

metaR r1571
is: SBO:0000185
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
fast: false
kinetic law: MODEL1310110045#
product: MODEL1310110045#
type: Reaction
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is described by: ECO:0000000
reactant: MODEL1310110045#

metaM retn e
is: HMDB01852
name: all-trans-retinoate
type: Species
has only substance units: false
boundary condition: false
is: SBO:0000247
notes: FORMULA: C20H27O2 CHARGE: -1 INCHI: InChI=1S/C20H28O2/c1-15(8-6-9-16(2)14-19(21)22)11-12-18-17(3)10-7-13-20(18,4)5/h6,8-9,11-12,14H,7,10,13H2,1-5H3,(H,21,22)/p-1/b9-6+,12-11+,15-8+,16-14+ HEPATONET_1.0_ABBREVIATION: HC00532 EHMN_ABBREVIATION: C00777
constant: false
initial concentration: 1.0
initial amount: NaN
is: CHEBI:35291

http://identifiers.org/biomodels.db/MODEL1310110045#_f3d05416_6286_47a2_a8d2_9578e9a8f44d
initial concentration: NaN
boundary condition: true
is encoded by: hsa:2686
has only substance units: false
is: A0PJJ9
name: GGT7
type: Species
initial amount: NaN
is: SBO:0000252
constant: false

metaR NRVNCt
product: MODEL1310110045#
kinetic law: MODEL1310110045#
is: SBO:0000185
is described by: ECO:0000000
reactant: MODEL1310110045#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11788354,PMID:12864740 NOTES:NJ
name: fatty acid transport via diffusion
reversible: true
fast: false
type: Reaction

metaR ADCim
reversible: false
name: Acetoacetate decarboxylation (irreversible), mitochondrial
reactant: MODEL1310110045#
type: Reaction
is: SBO:0000176
is described by: ECO:0000000
fast: false
kinetic law: MODEL1310110045#
product: MODEL1310110045#
notes: GENE_ASSOCIATION: SUBSYSTEM: Propanoate metabolism EC Number: 4.1.1.4 Confidence Level: 2 AUTHORS: NOTES:TDV (Voet & Voet pg 581) Non-enzymatic decarboxylation; spontaneous reaction added "m" suffix - NCD

metaM k c
has only substance units: false
is: C00238
name: potassium
constant: false
is: SBO:0000247
is: HMDB00586
notes: FORMULA: K CHARGE: 1 HEPATONET_1.0_ABBREVIATION: HC00216 EHMN_ABBREVIATION: C00238
type: Species
initial concentration: 1.0
boundary condition: false
initial amount: NaN
is: CHEBI:29103

metaR AKGMALtm
is: SBO:0000185
notes: GENE_ASSOCIATION: (8402.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172 NOTES:TV
is described by: ECO:0000269
reactant: MODEL1310110045#
type: Reaction
reversible: true
product: MODEL1310110045#
fast: false
name: alpha-ketoglutarate/malate transporter
modifier: MODEL1310110045#
kinetic law: MODEL1310110045#

metaM m4mpdol L c
is: SBO:0000247
is: CHEBI:37633
boundary condition: false
notes: FORMULA: C1540H2528N20O420P20 CHARGE: -20 INCHI: InChI=1S/C71H122N2O42P2/c1-30(2)13-9-14-31(3)15-10-16-32(4)17-11-18-33(5)19-12-20-34(6)21-22-101-116(96,97)115-117(98,99)114-66-45(73-36(8)81)52(88)60(42(28-79)107-66)109-65-44(72-35(7)80)51(87)61(41(27-78)106-65)110-69-59(95)62(50(86)43(108-69)29-100-67-57(93)53(89)46(82)37(23-74)102-67)111-70-64(56(92)49(85)39(25-76)104-70)113-71-63(55(91)48(84)40(26-77)105-71)112-68-58(94)54(90)47(83)38(24-75)103-68/h13,15,17,19,34,37-71,74-79,82-95H,9-12,14,16,18,20-29H2,1-8H3,(H,72,80)(H,73,81)(H,96,97)(H,98,99)/b31-15+,32-17+,33-19+/t34?,37-,38-,39-,40-,41-,42-,43-,44-,45-,46-,47-,48-,49-,50-,51-,52-,53+,54+,55+,56+,57+,58+,59+,60-,61-,62+,63+,64+,65+,66-,67+,68-,69+,70-,71-/m1/s1
constant: false
name: (alpha-D-Mannosyl)4-beta-D-mannosyl-diacetylchitobiosyldiphosphodolichol, human liver homolog
type: Species
initial concentration: 1.0
has only substance units: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110045#_6041b31d_18f4_442b_8f14_9c88539e2578
initial concentration: NaN
boundary condition: true
initial amount: NaN
has part: Q9UPY5
type: Species
is encoded by: hsa:23657
is: SBO:0000297
has only substance units: false
name: SLC7A11:SLC3A2
constant: false

http://identifiers.org/biomodels.db/MODEL1310110045#_10e2e23a_737a_4f03_b5fd_12ca7934dc00
is encoded by: hsa:7296
constant: false
type: Species
initial amount: NaN
is: SBO:0000252
boundary condition: true
name: TXNRD1
has only substance units: false
initial concentration: NaN

metaR EX ala L LPAREN e RPAREN
kinetic law: MODEL1310110045#
reactant: MODEL1310110045#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for L-alanine
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110045#_f6a022a4_e73a_4a83_a6b6_c436a4a56f8d
boundary condition: true
is: P15907
is: SBO:0000252
is encoded by: hsa:6480
name: ST6GAL1
initial concentration: NaN
initial amount: NaN
type: Species
constant: false
has only substance units: false

metaR RE2626C
kinetic law: MODEL1310110045#
fast: false
product: MODEL1310110045#
reversible: true
reactant: MODEL1310110045#
notes: GENE_ASSOCIATION: SUBSYSTEM: Bile acid synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:9210654,PMID:9660774 NOTES:
type: Reaction
name: RE2626
is: SBO:0000176
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110045#_ceae32ef_53ee_4fc8_9330_fa9338d72ef5
is: Q5SPY7
boundary condition: true
initial concentration: NaN
initial amount: NaN
is: SBO:0000252
name: ENTPD2
is encoded by: hsa:954
constant: false
type: Species
has only substance units: false

metaM 5aop m
is: SBO:0000247
is: HMDB01149
boundary condition: false
has only substance units: false
notes: FORMULA: C5H9NO3 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00349 EHMN_ABBREVIATION: C00430
type: Species
is: CHEBI:17549
initial amount: NaN
initial concentration: 1.0
constant: false
name: 5-Amino-4-oxopentanoate
is: C00430

http://identifiers.org/biomodels.db/MODEL1310110045#_60539a83_dcbd_4198_abde_670a19e46eca
initial amount: NaN
constant: false
type: Species
has only substance units: false
boundary condition: true
initial concentration: NaN
name: PKM2
is encoded by: hsa:5315
is: SBO:0000252

metaR r1576
is: SBO:0000185
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
product: MODEL1310110045#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is described by: ECO:0000000
kinetic law: MODEL1310110045#
fast: false
reactant: MODEL1310110045#
reversible: true

metaM HC02207 c
name: prostaglandin-c2
boundary condition: false
notes: FORMULA: C20H29O4 CHARGE: -1 INCHI: InChI=1S/C20H30O4/c1-2-3-6-9-17(21)14-12-16-13-15-19(22)18(16)10-7-4-5-8-11-20(23)24/h4,7,12-14,17-18,21H,2-3,5-6,8-11,15H2,1H3,(H,23,24)/b7-4-,14-12+/t17-,18+/m0/s1 EHMN_ABBREVIATION: C05955
type: Species
initial concentration: 1.0
is: SBO:0000247
initial amount: NaN
has only substance units: false
constant: false
is: CHEBI:27555

metaR EX pnto R LPAREN e RPAREN
kinetic law: MODEL1310110045#
reactant: MODEL1310110045#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: (R)-Pantothenate exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110045#_166ecbfa_be71_43c9_bc13_796e3fa94453
has only substance units: false
type: Species
name: SLC23A1
initial amount: NaN
boundary condition: true
is: SBO:0000252
constant: false
initial concentration: NaN
is encoded by: hsa:9963

metaR EBP1r
reversible: false
is version of: http://identifiers.org/ec-code/5.3.3.5
notes: GENE_ASSOCIATION: (10682.1) SUBSYSTEM: Cholesterol metabolism EC Number: 5.3.3.5 Confidence Level: 4 AUTHORS: PMID:10391219 NOTES:involved in lanosterol -> cholesterol pathway NJ
product: MODEL1310110045#
modifier: MODEL1310110045#
type: Reaction
reactant: MODEL1310110045#
kinetic law: MODEL1310110045#
name: 3-beta-hydroxysteroid-delta(8),delta(7)-isomerase
is described by: ECO:0000134
fast: false
is: SBO:0000176

metaM hdca r
boundary condition: false
initial concentration: 1.0
notes: FORMULA: C16H31O2 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00226 EHMN_ABBREVIATION: C00249
is: SBO:0000247
constant: false
name: Hexadecanoate (n-C16:0)
has only substance units: false
is: C00249
initial amount: NaN
is: HMDB00220
type: Species
is: CHEBI:7896

http://identifiers.org/biomodels.db/MODEL1310110045#_1177b553_5c89_4f46_a449_81ca50d418df
has only substance units: false
name: GALE
is: Q38G75
initial amount: NaN
boundary condition: true
is: SBO:0000252
type: Species
is encoded by: hsa:2582
constant: false
initial concentration: NaN

metaR MALSO4tm
kinetic law: MODEL1310110045#
notes: GENE_ASSOCIATION: (1468.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172,PMID:4441366 NOTES:MM
fast: false
reactant: MODEL1310110045#
is: SBO:0000185
name: Malate:sulfate antiport, mitochondrial
is described by: ECO:0000269
reversible: true
type: Reaction
product: MODEL1310110045#
modifier: MODEL1310110045#

metaM abt c
initial concentration: 1.0
type: Species
is: CHEBI:18403
is: HMDB01851
boundary condition: false
notes: FORMULA: C5H12O5 CHARGE: 0 INCHI: InChI=1S/C5H12O5/c6-1-3(8)5(10)4(9)2-7/h3-10H,1-2H2/t3-,4-/m0/s1 EHMN_ABBREVIATION: C00532
name: L-arabinitol
initial amount: NaN
constant: false
is: SBO:0000247
has only substance units: false

metaR EX prostge1 LPAREN e RPAREN
kinetic law: MODEL1310110045#
reactant: MODEL1310110045#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Prostaglandin E1 exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110045#_7493a631_718d_42c3_adae_1787088789f0
type: Species
constant: false
name: NDUFA3
has only substance units: false
initial concentration: NaN
boundary condition: true
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:4696
is: O95167

http://identifiers.org/biomodels.db/MODEL1310110045#_79294327_4a69_43aa_b8e6_6087d94bf2a1
constant: false
initial concentration: NaN
initial amount: NaN
boundary condition: true
is: SBO:0000252
is encoded by: hsa:54407
has only substance units: false
type: Species
is: Q96QD8
name: SLC38A2

metaM pro L c
name: L-proline
is: HMDB00162
initial concentration: 1.0
type: Species
has only substance units: false
constant: false
initial amount: NaN
notes: FORMULA: C5H9NO2 CHARGE: 0 INCHI: InChI=1S/C5H9NO2/c7-5(8)4-2-1-3-6-4/h4,6H,1-3H2,(H,7,8)/t4-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00145
boundary condition: false
is: SBO:0000247
is: CHEBI:17203

http://identifiers.org/biomodels.db/MODEL1310110045#_5a1a0bb4_0357_4aff_b46b_b12191ab7323
type: Species
is: SBO:0000252
initial concentration: NaN
boundary condition: true
constant: false
name: HADH
initial amount: NaN
is: Q16836
has only substance units: false
is encoded by: hsa:3033

http://identifiers.org/biomodels.db/MODEL1310110045#_f48781f6_75bd_405e_b498_46784496b29f
name: _T83654_1_c
is: SBO:0000252
initial concentration: NaN
initial amount: NaN
constant: false
has only substance units: false
boundary condition: true
type: Species
is encoded by: hsa:T83654

http://identifiers.org/biomodels.db/MODEL1310110045#_aec372c4_7247_48b6_8f86_f9b103830474
initial amount: NaN
boundary condition: true
initial concentration: NaN
is encoded by: hsa:7841
name: MOGS
is: F5H6D0
has only substance units: false
constant: false
type: Species
is: SBO:0000252

metaR AGTim
type: Reaction
name: alanine-glyoxylate transaminase (irreversible), mitochondrial
modifier: MODEL1310110045#
is: SBO:0000176
notes: GENE_ASSOCIATION: (64902.1) or (64850.1) SUBSYSTEM: Alanine and aspartate metabolism EC Number: 2.6.1.44 Confidence Level: 4 AUTHORS: PMID:15240345,PMID:9038835,PMID:9783918 NOTES:NCD
is version of: http://identifiers.org/ec-code/2.6.1.44
fast: false
is described by: ECO:0000269
reactant: MODEL1310110045#
reversible: false
kinetic law: MODEL1310110045#
product: MODEL1310110045#

http://identifiers.org/biomodels.db/MODEL1310110045#_4bae0286_e0c8_4161_9a6b_1ac82293ecbd
type: Species
name: GAPDH
is: SBO:0000252
initial amount: NaN
initial concentration: NaN
is: E7EUT4
is encoded by: hsa:2597
constant: false
has only substance units: false
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110045#_9fddcfba_e563_48e7_bf14_dba011fdb107
is: Q9Y2Q0
name: ATP8A1
initial amount: NaN
is encoded by: hsa:10396
has only substance units: false
boundary condition: true
initial concentration: NaN
type: Species
constant: false
is: SBO:0000252

metaR NRPPHRSFt
name: norepinephrine sulfate transport (diffusion)
type: Reaction
reactant: MODEL1310110045#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 1 AUTHORS: NOTES:SAB
product: MODEL1310110045#
is described by: ECO:0000000
is: SBO:0000185
kinetic law: MODEL1310110045#
reversible: false

metaR 7DHFtl
kinetic law: MODEL1310110045#
name: 7-glutamyl-DHF transport, lysosomal
type: Reaction
product: MODEL1310110045#
reactant: MODEL1310110045#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 2 AUTHORS: PMID:11375437 NOTES:carrier-mediated transport - but which and how is unknown IT
fast: false
reversible: false
is: SBO:0000185
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110045#_1262a102_4a8c_4c92_a0be_9765429455dd
initial amount: NaN
has only substance units: false
constant: false
is: SBO:0000252
initial concentration: NaN
type: Species
boundary condition: true
is: Q92523
name: CPT1B
is encoded by: hsa:1375

metaM HC02207 e
name: prostaglandin-c2
type: Species
boundary condition: false
is: SBO:0000247
initial concentration: 1.0
notes: FORMULA: C20H29O4 CHARGE: -1 INCHI: InChI=1S/C20H30O4/c1-2-3-6-9-17(21)14-12-16-13-15-19(22)18(16)10-7-4-5-8-11-20(23)24/h4,7,12-14,17-18,21H,2-3,5-6,8-11,15H2,1H3,(H,23,24)/b7-4-,14-12+/t17-,18+/m0/s1 EHMN_ABBREVIATION: C05955
initial amount: NaN
constant: false
is: CHEBI:27555
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110045#_b0fa238f_42ee_4c3b_91ce_2af551a5ed66
initial concentration: NaN
constant: false
type: Species
is encoded by: hsa:7264
initial amount: NaN
has only substance units: false
is: Q13630
is: SBO:0000252
boundary condition: true
name: TSTA3

metaR r1574
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reactant: MODEL1310110045#
is: SBO:0000185
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
type: Reaction
product: MODEL1310110045#
kinetic law: MODEL1310110045#
is described by: ECO:0000000
fast: false
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110045#_dd471186_2740_4b0d_ad89_d5a5b8ffcb8f
is encoded by: hsa:100
boundary condition: true
name: ADA
initial concentration: NaN
type: Species
initial amount: NaN
is: SBO:0000252
constant: false
is: P00813
has only substance units: false

metaM n2m2nmasn e
notes: FORMULA: C58H96N5O40X CHARGE: 0
name: N-Acetyl-beta-D-glucosaminyl-1,2-alpha-D-mannosyl-1,3-(N-acetyl-beta-D-glucosaminyl-1,2-alpha-D-mannosyl-1,6)-(N-acetyl-beta-D-glucosaminyl-1,4)-beta-D-mannosyl-1,4-N-acetyl-beta-D-glucosaminyl-R
boundary condition: false
initial concentration: 1.0
is: C04946
constant: false
initial amount: NaN
is: SBO:0000247
type: Species
has only substance units: false

metaR FATP9t
reversible: true
fast: false
name: fatty acid electroneutral transport
product: MODEL1310110045#
notes: GENE_ASSOCIATION: (10998.1) or (11001.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10479480,PMID:12856180,PMID:15522816 NOTES:electroneutral transport NJ
kinetic law: MODEL1310110045#
reactant: MODEL1310110045#
is described by: ECO:0000269
type: Reaction
is version of: http://identifiers.org/ec-code/6.2.1.3
modifier: MODEL1310110045#
is: SBO:0000185
is version of: http://identifiers.org/ec-code/6.2.1.7

metaR EX HC01104 LPAREN e RPAREN
kinetic law: MODEL1310110045#
reactant: MODEL1310110045#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of 4-nitrophenyl phosphate(2-)
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110045#_f1fae828_a170_46ff_aee3_6df1b113d41d
initial amount: NaN
is: SBO:0000252
name: _2544_1_c
boundary condition: true
constant: false
has only substance units: false
is encoded by: hsa:2544
type: Species
initial concentration: NaN

metaM abt e
is: HMDB01851
type: Species
initial concentration: 1.0
is: CHEBI:18403
initial amount: NaN
constant: false
is: SBO:0000247
boundary condition: false
notes: FORMULA: C5H12O5 CHARGE: 0 INCHI: InChI=1S/C5H12O5/c6-1-3(8)5(10)4(9)2-7/h3-10H,1-2H2/t3-,4-/m0/s1 EHMN_ABBREVIATION: C00532
name: L-arabinitol
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110045#_bfcbf401_3bb1_48df_a37c_14a28aa4977c
is: P43353
boundary condition: true
is: SBO:0000252
has only substance units: false
initial amount: NaN
constant: false
is encoded by: hsa:221
name: ALDH3B1
type: Species
initial concentration: NaN

metaR G14T16g
notes: GENE_ASSOCIATION: (8703.1) or (2683.1) or (8704.2) or (8704.1) or (9334.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.38 Confidence Level: 4 AUTHORS: PMID:12512857,PMID:1903938,PMID:3094506,PMID:3144273,PMID:9405390,PMID:9435216 NOTES:Keratan sulfate I biosynthesis NCD
modifier: MODEL1310110045#
product: MODEL1310110045#
is version of: http://identifiers.org/ec-code/2.4.1.90
is: SBO:0000176
type: Reaction
reversible: false
kinetic law: MODEL1310110045#
is version of: http://identifiers.org/ec-code/2.4.1.22
reactant: MODEL1310110045#
is described by: ECO:0000000
name: beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase, Golgi
is version of: http://identifiers.org/ec-code/2.4.1.38
fast: false

metaM eitetcoa m
notes: FORMULA: C41H62N7O17P3S CHARGE: -4
has only substance units: false
constant: false
type: Species
is: SBO:0000247
initial concentration: 1.0
is: HMDB06294
boundary condition: false
initial amount: NaN
name: 5,8,11,14-eicosatetraenoylcoa

http://identifiers.org/biomodels.db/MODEL1310110045#_ef6ecc78_e92b_4ff3_9e59_179d9ce186cd
name: ABP1
initial amount: NaN
is: SBO:0000252
has only substance units: false
is: P19801
boundary condition: true
is encoded by: hsa:26
type: Species
constant: false
initial concentration: NaN

metaR EX CE1943 LPAREN e RPAREN
kinetic law: MODEL1310110045#
reactant: MODEL1310110045#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: spermidine dialdehyde exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110045#_3eb85ba7_7092_4fe4_8a09_4d472883f3e3
type: Species
initial concentration: NaN
boundary condition: true
is: P42765
is encoded by: hsa:10449
constant: false
initial amount: NaN
has only substance units: false
name: ACAA2
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110045#_6317a244_d8f8_41e7_af6e_b6ed5849cf94
is: P21589
name: NT5E
is encoded by: hsa:4907
is: SBO:0000252
constant: false
has only substance units: false
initial amount: NaN
boundary condition: true
type: Species
initial concentration: NaN

metaR 4MOPte
reversible: true
fast: false
kinetic law: MODEL1310110045#
is: SBO:0000185
type: Reaction
is described by: ECO:0000134
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
reactant: MODEL1310110045#
name: Transport of 4-methyl-2-oxopentanoate
product: MODEL1310110045#

metaR FUMTSULtm
product: MODEL1310110045#
kinetic law: MODEL1310110045#
modifier: MODEL1310110045#
is: SBO:0000185
reversible: true
is described by: ECO:0000269
fast: false
reactant: MODEL1310110045#
type: Reaction
name: Fumarate:thiosulfate antiport, mitochondrial
notes: GENE_ASSOCIATION: (1468.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172,PMID:4441366 NOTES:MM

metaR r1575
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
product: MODEL1310110045#
reversible: true
type: Reaction
kinetic law: MODEL1310110045#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
fast: false
is described by: ECO:0000000
reactant: MODEL1310110045#
is: SBO:0000185

metaR 7DHFtm
name: 7-glutamyl-DHF transport,m mitochondrial
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: PMID:11375437 NOTES:unknown mechanism. IT
fast: false
is described by: ECO:0000000
reversible: false
type: Reaction
reactant: MODEL1310110045#
kinetic law: MODEL1310110045#
is: SBO:0000185
product: MODEL1310110045#

metaR NRVNCCOAtxc
kinetic law: MODEL1310110045#
product: MODEL1310110045#
reactant: MODEL1310110045#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of nervonylcoa into peroxisomes
type: Reaction

metaM his L c
has only substance units: false
initial amount: NaN
is: HMDB00177
is: SBO:0000247
boundary condition: false
notes: FORMULA: C6H9N3O2 CHARGE: 0 INCHI: InChI=1S/C6H9N3O2/c7-5(6(10)11)1-4-2-8-3-9-4/h2-3,5H,1,7H2,(H,8,9)(H,10,11)/t5-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00133
initial concentration: 1.0
is: CHEBI:15971
name: L-histidine
type: Species
constant: false

metaM occoa m
is: C01944
has only substance units: false
is: HMDB01070
initial amount: NaN
name: Octanoyl-CoA (n-C8:0CoA)
boundary condition: false
is: SBO:0000247
type: Species
initial concentration: 1.0
constant: false
notes: FORMULA: C29H46N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00869 EHMN_ABBREVIATION: C01944
is: CHEBI:57386

metaM HC02216 c
is: CHEBI:28922
initial amount: NaN
notes: FORMULA: C20H33O5 CHARGE: -1 INCHI: InChI=1S/C20H34O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h4,7,12-13,15-19,21-23H,2-3,5-6,8-11,14H2,1H3,(H,24,25)/b7-4-,13-12+/t15-,16+,17+,18+,19+/m0/s1
name: prostaglandin-f2beta
boundary condition: false
initial concentration: 1.0
constant: false
type: Species
is: SBO:0000247
has only substance units: false

metaM ala B m
boundary condition: false
is: HMDB00056
is: SBO:0000247
initial concentration: 1.0
has only substance units: false
is: CHEBI:16958
name: beta-alanine
initial amount: NaN
constant: false
type: Species
notes: FORMULA: C3H7NO2 CHARGE: 0 INCHI: InChI=1S/C3H7NO2/c4-2-1-3(5)6/h1-2,4H2,(H,5,6) HEPATONET_1.0_ABBREVIATION: HC00100

http://identifiers.org/biomodels.db/MODEL1310110045#_bfc195d0_1aba_40af_b695_357fafd63a24
initial concentration: NaN
is: O14556
name: GAPDHS
type: Species
is: SBO:0000252
has only substance units: false
is encoded by: hsa:26330
boundary condition: true
initial amount: NaN
constant: false

metaR TRDR
type: Reaction
reversible: false
fast: false
product: MODEL1310110045#
is version of: http://identifiers.org/ec-code/1.8.1.9
is: SBO:0000176
notes: GENE_ASSOCIATION: (7296.3) or (7296.1) or (7296.4) or (7296.2) SUBSYSTEM: Nucleotide interconversion EC Number: 1.8.1.9 Confidence Level: 4 AUTHORS: PMID:8577704,PMID:8999974 NOTES:
kinetic law: MODEL1310110045#
is described by: ECO:0000269
name: thioredoxin reductase (NADPH)
reactant: MODEL1310110045#
modifier: MODEL1310110045#

metaR r0774
type: Reaction
is version of: http://identifiers.org/ec-code/4.2.1.107
fast: false
product: MODEL1310110045#
is: SBO:0000176
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (1962.1) or (3033.1) or (3030.1) or (3028.1) or (3295.1) SUBSYSTEM: Unassigned EC Number: 4.1.1.37 Confidence Level: 0 AUTHORS: PMID:17360334 NOTES:
name: Uroporphyrinogen I carboxy-lyase Porphyrin and chlorophyll metabolism EC:4.1.1.37
reversible: true
is version of: http://identifiers.org/ec-code/4.2.1.17
kinetic law: MODEL1310110045#
reactant: MODEL1310110045#
is version of: http://identifiers.org/ec-code/1.1.1.35
modifier: MODEL1310110045#

metaR NDPK3n
is: SBO:0000176
notes: GENE_ASSOCIATION: (4831.1 and 4830.1) or (4830.2 and 4831.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.6 Confidence Level: 4 AUTHORS: PMID:7050910 NOTES:Many nucleoside diphosphates (eight described) can act as acceptors. While many ribo- and deoxyribonucleoside triphosphates can act as donors, only ATP is chosen as a donor to minimize the number of total reactions.. Presence in the nucleus
fast: false
is version of: http://identifiers.org/ec-code/2.7.4.6
type: Reaction
modifier: MODEL1310110045#
reactant: MODEL1310110045#
is described by: ECO:0000304
product: MODEL1310110045#
name: nucleoside-diphosphate kinase (ATP:CDP),nuclear
reversible: true
kinetic law: MODEL1310110045#

metaM mi134p c
is: SBO:0000247
initial amount: NaN
constant: false
has only substance units: false
is: HMDB01143
initial concentration: 1.0
is: CHEBI:58414
type: Species
boundary condition: false
notes: FORMULA: C6H9O15P3 CHARGE: -6 INCHI: InChI=1S/C6H15O15P3/c7-1-2(8)5(20-23(13,14)15)6(21-24(16,17)18)3(9)4(1)19-22(10,11)12/h1-9H,(H2,10,11,12)(H2,13,14,15)(H2,16,17,18)/p-6/t1-,2-,3+,4+,5+,6+/m1/s1 EHMN_ABBREVIATION: C01243
name: 1D-myo-inositol 1,3,4-trisphosphate(6-)

metaM lnlccrn c
constant: false
boundary condition: false
type: Species
is: HMDB06469
initial amount: NaN
notes: FORMULA: C25H45NO4 CHARGE: 0 INCHI: InChI=1/C25H45NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-25(29)30-23(21-24(27)28)22-26(2,3)4/h9-10,12-13,23H,5-8,11,14-22H2,1-4H3/b10-9-,13-12-/t23-/m1/s1
has only substance units: false
is: SBO:0000247
initial concentration: 1.0
name: Linoleyl carnitine

http://identifiers.org/biomodels.db/MODEL1310110045#_a35c1d9e_11b0_4b18_9a62_06ff373a720f
is encoded by: hsa:8854
initial amount: NaN
is: SBO:0000252
boundary condition: true
has only substance units: false
name: ALDH1A2
is: F5H2Y9
type: Species
initial concentration: NaN
constant: false

metaR NDPK3m
is described by: ECO:0000254
is: SBO:0000176
fast: false
reversible: true
is version of: http://identifiers.org/ec-code/2.7.4.6
product: MODEL1310110045#
modifier: MODEL1310110045#
type: Reaction
notes: GENE_ASSOCIATION: (4833.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.6 Confidence Level: 2 AUTHORS: PMID:9099850 NOTES:Many nucleoside diphosphates (eight described) can act as acceptors. While many ribo- and deoxyribonucleoside triphosphates can act as donors, only ATP is chosen as a donor to minimize the number of total reactions.
name: nucleoside-diphosphate kinase (ATP:CDP), mitochondrial
reactant: MODEL1310110045#
kinetic law: MODEL1310110045#

metaR TMDPK
fast: false
product: MODEL1310110045#
notes: GENE_ASSOCIATION: (27010.1) SUBSYSTEM: Thiamine metabolism EC Number: Confidence Level: 4 AUTHORS: NOTES:
is version of: http://identifiers.org/ec-code/2.7.6.2
modifier: MODEL1310110045#
kinetic law: MODEL1310110045#
is described by: ECO:0000269
is: SBO:0000176
type: Reaction
name: Thiamin pyrophosphokinase (EC 2.7.6.2)
reversible: false
reactant: MODEL1310110045#

metaM h e
notes: FORMULA: H CHARGE: 1 INCHI: "
is: C00080
initial concentration: 1.0
is: CHEBI:24636
is: SBO:0000247
boundary condition: false
has only substance units: false
initial amount: NaN
is: http://identifiers.org/pubchem.compound/3380
constant: false
type: Species
name: proton

metaR GALASE10ly
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/3.1.6.4
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) or (5476.1) and (2720.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.23 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD
is version of: http://identifiers.org/ec-code/3.2.1.18
product: MODEL1310110045#
is version of: http://identifiers.org/ec-code/3.4.16.5
name: beta-galactosidase, lysosomal
fast: false
is version of: http://identifiers.org/ec-code/3.2.1.23
is: SBO:0000176
reactant: MODEL1310110045#
reversible: false
modifier: MODEL1310110045#
type: Reaction
kinetic law: MODEL1310110045#

metaR GLUDym
product: MODEL1310110045#
fast: false
is described by: ECO:0000269
name: glutamate dehydrogenase (NADP), mitochondrial
is version of: http://identifiers.org/ec-code/1.4.1.3
notes: GENE_ASSOCIATION: (2747.1) or (2746.1) SUBSYSTEM: Glutamate metabolism EC Number: 1.4.1.4 Confidence Level: 4 AUTHORS: PMID:12324473,PMID:3368458 NOTES:
modifier: MODEL1310110045#
reactant: MODEL1310110045#
kinetic law: MODEL1310110045#
type: Reaction
reversible: true
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110045#_a2bfab65_35a2_4583_a553_074daeba06f0
is: O14495
is encoded by: hsa:8613
has only substance units: false
constant: false
is: SBO:0000252
initial concentration: NaN
initial amount: NaN
type: Species
boundary condition: true
name: PPAP2B

metaR r0618
name: trans-4-Hydroxy-L-proline:NADP+ 5-oxidoreductase Arginine and proline metabolism EC:1.5.1.2
reversible: true
fast: false
is: SBO:0000176
kinetic law: MODEL1310110045#
reactant: MODEL1310110045#
is described by: ECO:0000000
product: MODEL1310110045#
notes: GENE_ASSOCIATION: SUBSYSTEM: Arginine and Proline Metabolism EC Number: 1.5.1.2 Confidence Level: 0 AUTHORS: PMID:12514185,PMID:3768405,PMID:6250440,PMID:675382 NOTES:
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110045#_58a9c9fb_3038_4f5b_bc7b_ae4961bf57a2
initial amount: NaN
is: P49189
has only substance units: false
name: ALDH9A1
type: Species
is: SBO:0000252
initial concentration: NaN
boundary condition: true
is encoded by: hsa:223
constant: false

metaM atp m
initial concentration: 1.0
constant: false
is: HMDB00538
name: ATP(4-)
is: C00002
type: Species
is: SBO:0000247
is: CHEBI:57299
boundary condition: false
initial amount: NaN
has only substance units: false

metaM asp D x
boundary condition: false
initial concentration: 1.0
is: SBO:0000247
is: CHEBI:29990
type: Species
constant: false
name: D-aspartate(1-)
notes: FORMULA: C4H6NO4 CHARGE: -1 INCHI: InChI=1S/C4H7NO4/c5-2(4(8)9)1-3(6)7/h2H,1,5H2,(H,6,7)(H,8,9)/p-1/t2-/m1/s1
initial amount: NaN
has only substance units: false
is: HMDB06483

metaM dcsptn1coa m
initial amount: NaN
is: HMDB06513
is: C16173
boundary condition: false
is: SBO:0000247
type: Species
initial concentration: 1.0
name: docosa-4,7,10,13,16-pentaenoyl coenzyme A
has only substance units: false
notes: FORMULA: C43H64N7O17P3S CHARGE: -4 INCHI: InChI=1/C43H68N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-34(52)71-27-26-45-33(51)24-25-46-41(55)38(54)43(2,3)29-64-70(61,62)67-69(59,60)63-28-32-37(66-68(56,57)58)36(53)42(65-32)50-31-49-35-39(44)47-30-48-40(35)50/h8-9,11-12,14-15,17-18,20-21,30-32,36-38,42,53-54H,4-7,10,13,16,19,22-29H2,1-3H3,(H,45,51)(H,46,55)(H,59,60)(H,61,62)(H2,44,47,48)(H2,56,57,58)/b9-8-,12-11-,15-14-,18-17-,21-20-/t32-,36-,37?,38+,42-/m1/s1
is: http://identifiers.org/pubchem.compound/47205483
constant: false

metaM l2fn2m2masn g
type: Species
has only substance units: false
constant: false
name: {[galactosyl-(1,4)-N-Acetyl-glucosaminyl-(1,2)-mannosyl-(1,3)-],[N-acetyl-glucosaminyl-(1,2)-mannosyl-(1,6)-]mannosyl-(1,4)-N-acetyl-glucosaminyl-(1,4)-[fucosyl-(1,6)]-N-acetyl-glucosaminyl}asparagine
is: CHEBI:28067
notes: FORMULA: C68H113N4O49X CHARGE: 0
initial amount: NaN
is: SBO:0000247
initial concentration: 1.0
boundary condition: false

metaM HC02205 e
type: Species
has only substance units: false
boundary condition: false
is: CHEBI:28099
notes: FORMULA: C20H29O4 CHARGE: -1 INCHI: InChI=1S/C20H30O4/c1-2-3-6-9-17(21)14-12-16-13-15-19(22)18(16)10-7-4-5-8-11-20(23)24/h4,7,12,14,17,21H,2-3,5-6,8-11,13,15H2,1H3,(H,23,24)/b7-4-,14-12+/t17-/m0/s1 EHMN_ABBREVIATION: C05954
is: SBO:0000247
constant: false
name: prostaglandin-b2
initial amount: NaN
initial concentration: 1.0

metaM HC02216 e
constant: false
is: SBO:0000247
initial amount: NaN
type: Species
boundary condition: false
notes: FORMULA: C20H33O5 CHARGE: -1 INCHI: InChI=1S/C20H34O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h4,7,12-13,15-19,21-23H,2-3,5-6,8-11,14H2,1H3,(H,24,25)/b7-4-,13-12+/t15-,16+,17+,18+,19+/m0/s1
has only substance units: false
is: CHEBI:28922
name: prostaglandin-f2beta
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110045#_45dab063_bd0e_4325_8115_30bbbf0eeb76
boundary condition: true
is: P43353
constant: false
has only substance units: false
type: Species
is encoded by: hsa:221
name: ALDH3B1
initial amount: NaN
is: SBO:0000252
initial concentration: NaN

metaM his L e
is: HMDB00177
is: SBO:0000247
has only substance units: false
boundary condition: false
is: CHEBI:15971
notes: FORMULA: C6H9N3O2 CHARGE: 0 INCHI: InChI=1S/C6H9N3O2/c7-5(6(10)11)1-4-2-8-3-9-4/h2-3,5H,1,7H2,(H,8,9)(H,10,11)/t5-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00133
initial concentration: 1.0
type: Species
name: L-histidine
constant: false
initial amount: NaN

metaM na1 r
name: sodium(1+)
initial amount: NaN
is: CHEBI:29101
initial concentration: 1.0
type: Species
boundary condition: false
is: SBO:0000247
has only substance units: false
is: HMDB00588
constant: false
notes: FORMULA: Na CHARGE: 1 INCHI: InChI=1S/Na/q+1 HEPATONET_1.0_ABBREVIATION: HC00763 EHMN_ABBREVIATION: C01330

http://identifiers.org/biomodels.db/MODEL1310110045#_12ffc706_8c7e_443e_8b12_058e05b459d2
constant: false
is: SBO:0000252
is: Q9HAB8
initial amount: NaN
has only substance units: false
initial concentration: NaN
type: Species
boundary condition: true
is encoded by: hsa:79717
name: PPCS

metaM ppi c
name: Diphosphate
initial concentration: 1.0
boundary condition: false
is: HMDB00250
is: C00013
constant: false
is: CHEBI:0
initial amount: NaN
notes: FORMULA: HO7P2 CHARGE: -3
is: SBO:0000247
has only substance units: false
type: Species

metaR XYLTt
is described by: ECO:0000000
is: SBO:0000185
kinetic law: MODEL1310110045#
type: Reaction
name: Xylitol transport via passive diffusion
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 1 AUTHORS: PMID:6821187 NOTES:NCD
reversible: true
fast: false
reactant: MODEL1310110045#
product: MODEL1310110045#

http://identifiers.org/biomodels.db/MODEL1310110045#_e174937e_a790_4df0_bf89_9047119bfc30
name: SLC25A10
initial concentration: NaN
type: Species
is: Q9UBX3
has only substance units: false
constant: false
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:1468
boundary condition: true

metaR EX leuktrF4 LPAREN e RPAREN
kinetic law: MODEL1310110045#
reactant: MODEL1310110045#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: leukotriene F4 exchange
type: Reaction

metaR r1579
type: Reaction
fast: false
reactant: MODEL1310110045#
kinetic law: MODEL1310110045#
is described by: ECO:0000000
reversible: true
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is: SBO:0000185
product: MODEL1310110045#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110045#_7cc30a29_3853_4e89_a633_4a4d6dbda43b
is: A8K3L7
is encoded by: hsa:10423
is: SBO:0000252
type: Species
initial concentration: NaN
has only substance units: false
constant: false
initial amount: NaN
name: CDIPT
boundary condition: true

metaR r0494
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Pyrimidine catabolism EC Number: 3.6.1.5 Confidence Level: 0 AUTHORS: PMID:15652174,PMID:16752921,PMID:17095758 NOTES:
fast: false
product: MODEL1310110045#
reversible: true
name: dTDP diphosphohydrolase Pyrimidine metabolism EC:3.6.1.5
reactant: MODEL1310110045#
is described by: ECO:0000000
type: Reaction
kinetic law: MODEL1310110045#

metaM adp r
notes: FORMULA: C10H12N5O10P2 CHARGE: -3 INCHI: InChI=1S/C10H15N5O10P2/c11-8-5-9(13-2-12-8)15(3-14-5)10-7(17)6(16)4(24-10)1-23-27(21,22)25-26(18,19)20/h2-4,6-7,10,16-17H,1H2,(H,21,22)(H2,11,12,13)(H2,18,19,20)/p-3/t4-,6-,7-,10-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00018 EHMN_ABBREVIATION: C00008
boundary condition: false
has only substance units: false
is: SBO:0000247
is: HMDB01341
constant: false
is: CHEBI:456216
initial amount: NaN
initial concentration: 1.0
name: ADP(3-)
type: Species

http://identifiers.org/biomodels.db/MODEL1310110045#_2743555f_495b_4340_b0c3_80ecea13cb1e
boundary condition: true
type: Species
is: SBO:0000252
initial concentration: NaN
constant: false
name: _BC005314_1_x
is encoded by: hsa:BC005314
initial amount: NaN
has only substance units: false

metaM atp n
is: CHEBI:57299
boundary condition: false
constant: false
is: HMDB00538
type: Species
is: SBO:0000247
initial amount: NaN
initial concentration: 1.0
notes: FORMULA: C10H12N5O13P3 CHARGE: -4 INCHI: InChI=1S/C10H16N5O13P3/c11-8-5-9(13-2-12-8)15(3-14-5)10-7(17)6(16)4(26-10)1-25-30(21,22)28-31(23,24)27-29(18,19)20/h2-4,6-7,10,16-17H,1H2,(H,21,22)(H,23,24)(H2,11,12,13)(H2,18,19,20)/p-3/t4-,6-,7-,10-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00012 EHMN_ABBREVIATION: C00002
name: ATP(3-)
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110045#_eee52fa7_663f_4fda_bc7b_36a6b30279a3
constant: false
initial concentration: NaN
initial amount: NaN
has only substance units: false
is: SBO:0000252
is encoded by: hsa:81539
is: Q9H2H9
boundary condition: true
name: SLC38A1
type: Species

metaR r1401
is version of: http://identifiers.org/ec-code/2.3.1.41
is version of: http://identifiers.org/ec-code/3.2.1.35
is: SBO:0000185
is version of: http://identifiers.org/ec-code/2.7.10.1
is version of: http://identifiers.org/ec-code/2.3.1.51
type: Reaction
name: Facilitated diffusion
notes: GENE_ASSOCIATION: (AA177072.1) or (AA203143.1) or (56894.1) or (56895.1) or (AGPAT7.1) or (AI818585.1) or (AI971023.1) or (1956.1) or (54898.1) or (60481.1) or (79071.1) or (114799.1) or (157570.1) or (8372.1) or (LOC647190.1) or (9926.1) or (129642.1) or (MBOAT5.1) or (79143.1) or (N63787.1) or (54995.1) or (80339.1) or (9197.1) or (6901.1) or (W87865.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:6361812,PMID:8132483 NOTES:
kinetic law: MODEL1310110045#
reversible: false
product: MODEL1310110045#
reactant: MODEL1310110045#
fast: false
is described by: ECO:0000000
modifier: MODEL1310110045#
is version of: http://identifiers.org/ec-code/3.1.1.3

metaM h g
type: Species
has only substance units: false
initial amount: NaN
initial concentration: 1.0
is: SBO:0000247
name: proton
is: CHEBI:24636
notes: FORMULA: H CHARGE: 1 INCHI: InChI=1S/p+1/i/hH HEPATONET_1.0_ABBREVIATION: HC00083 EHMN_ABBREVIATION: C00080
constant: false
boundary condition: false

metaR r0616
type: Reaction
product: MODEL1310110045#
kinetic law: MODEL1310110045#
reversible: true
notes: GENE_ASSOCIATION: (C7orf24.1) SUBSYSTEM: Arginine and Proline Metabolism EC Number: 1.5.1.2 Confidence Level: 0 AUTHORS: PMID:12514185,PMID:3768405,PMID:6250440,PMID:675382 NOTES:
modifier: MODEL1310110045#
is: SBO:0000176
reactant: MODEL1310110045#
is described by: ECO:0000000
name: trans-4-Hydroxy-L-proline:NAD+ 5-oxidoreductase Arginine and proline metabolism EC:1.5.1.2
fast: false

metaR r1168
reactant: MODEL1310110045#
product: MODEL1310110045#
name: EC:2.3.1.26
fast: false
kinetic law: MODEL1310110045#
reversible: false
type: Reaction
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 2.3.1.26 Confidence Level: 0 AUTHORS: PMID:2760547,PMID:7822296,PMID:9242919 NOTES:
is described by: ECO:0000000

metaR ABTD
fast: false
name: L-arabinitol 4-dehydrogenase
is described by: ECO:0000000
product: MODEL1310110045#
reversible: true
reactant: MODEL1310110045#
notes: GENE_ASSOCIATION: SUBSYSTEM: Pentose phosphate pathway EC Number: 1.1.1.12 Confidence Level: 2 AUTHORS: PMID:12359133,PMID:13922173,PMID:15234337 NOTES:NCD
is: SBO:0000176
type: Reaction
kinetic law: MODEL1310110045#

metaR r1578
product: MODEL1310110045#
is: SBO:0000185
reversible: true
fast: false
reactant: MODEL1310110045#
kinetic law: MODEL1310110045#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110045#_b14d5faf_584e_4978_a36c_040dab5c6e70
boundary condition: true
type: Species
is: SBO:0000252
constant: false
initial concentration: NaN
name: OCRL
is: Q01968
is encoded by: hsa:4952
has only substance units: false
initial amount: NaN

metaM acald e
is: SBO:0000247
initial concentration: 1.0
initial amount: NaN
name: acetaldehyde
constant: false
notes: FORMULA: C2H4O CHARGE: 0 INCHI: InChI=1S/C2H4O/c1-2-3/h2H,1H3 HEPATONET_1.0_ABBREVIATION: HC00087 EHMN_ABBREVIATION: C00084
type: Species
boundary condition: false
is: CHEBI:15343
has only substance units: false
is: HMDB00990

metaM ksi pre31 g
name: keratan sulfate I biosynthesis, precursor 31
is: SBO:0000247
is: HMDB00175
boundary condition: false
has only substance units: false
notes: FORMULA: C227H363N16O189S9X CHARGE: -10
is: C00130
is: CHEBI:58053
initial concentration: 1.0
type: Species
initial amount: NaN
constant: false

metaM CE2424 m
type: Species
is: CHEBI:28387
constant: false
notes: FORMULA: C35H52N7O18P3S CHARGE: -4 INCHI: InChI=1/C35H56N7O18P3S/c1-4-5-6-7-8-9-10-11-12-13-23(43)18-26(45)64-17-16-37-25(44)14-15-38-33(48)30(47)35(2,3)20-57-63(54,55)60-62(52,53)56-19-24-29(59-61(49,50)51)28(46)34(58-24)42-22-41-27-31(36)39-21-40-32(27)42/h8-9,11-12,21-22,24,28-30,34,46-47H,4-7,10,13-20H2,1-3H3,(H,37,44)(H,38,48)(H,52,53)(H,54,55)(H2,36,39,40)(H2,49,50,51)/p-4/b9-8-,12-11-/t24-,28+,29+,30u,34-/m0/s1 EHMN_ABBREVIATION: CE2424
has only substance units: false
initial concentration: 1.0
is: HMDB11123
is: SBO:0000247
initial amount: NaN
boundary condition: false
name: 3-oxo-cis,cis-5,8-tetradecadienoyl-CoA

http://identifiers.org/biomodels.db/MODEL1310110045#_0a8bad31_f89f_41dd_92c6_81691faeed60
type: Species
name: PIP4K2A
is: SBO:0000252
is encoded by: hsa:5305
has only substance units: false
initial amount: NaN
boundary condition: true
initial concentration: NaN
constant: false
is: P48426

metaM HC02205 c
is: CHEBI:28099
initial amount: NaN
constant: false
boundary condition: false
has only substance units: false
notes: FORMULA: C20H29O4 CHARGE: -1 INCHI: InChI=1S/C20H30O4/c1-2-3-6-9-17(21)14-12-16-13-15-19(22)18(16)10-7-4-5-8-11-20(23)24/h4,7,12,14,17,21H,2-3,5-6,8-11,13,15H2,1H3,(H,23,24)/b7-4-,14-12+/t17-/m0/s1 EHMN_ABBREVIATION: C05954
name: prostaglandin-b2
initial concentration: 1.0
is: SBO:0000247
type: Species

metaR FAOXC200180m
fast: false
is version of: http://identifiers.org/ec-code/1.3.99.3
is: SBO:0000176
modifier: MODEL1310110045#
name: Beta oxidation of long chain fatty acid
reversible: false
type: Reaction
is described by: ECO:0000000
reactant: MODEL1310110045#
product: MODEL1310110045#
notes: GENE_ASSOCIATION: (35.1) or (34.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.74 Confidence Level: 4 AUTHORS: NOTES:c20:0 -> c18:0 4 step FAO lumped also includes EC 1.1.1.35, 1.1.1.211, 1.3.3.6, 4.2.1.17, 4.2.1.74 NJ
kinetic law: MODEL1310110045#
is version of: http://identifiers.org/ec-code/1.3.8.1

metaR EX malthp LPAREN e RPAREN
kinetic law: MODEL1310110045#
reactant: MODEL1310110045#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: maltoheptaose exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110045#_a50ef99e_4c6f_42d6_a635_fa9bef4edfe5
has only substance units: false
type: Species
initial concentration: NaN
is: SBO:0000252
initial amount: NaN
constant: false
name: _AI697028_1_e
boundary condition: true
is encoded by: hsa:AI697028

metaM thyox L e
notes: FORMULA: C15H11I4NO4 CHARGE: 0 INCHI: InChI=1S/C15H11I4NO4/c16-8-4-7(5-9(17)13(8)21)24-14-10(18)1-6(2-11(14)19)3-12(20)15(22)23/h1-2,4-5,12,21H,3,20H2,(H,22,23)/t12-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00849
has only substance units: false
initial amount: NaN
type: Species
name: L-thyroxine
is: CHEBI:18332
constant: false
boundary condition: false
is: SBO:0000247
is: HMDB00248
initial concentration: 1.0

metaR r1400
reactant: MODEL1310110045#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 0 AUTHORS: PMID:12133002,PMID:4475632,PMID:5810070 NOTES:
product: MODEL1310110045#
name: Active transport
is described by: ECO:0000000
reversible: false
fast: false
is: SBO:0000185
kinetic law: MODEL1310110045#

metaM din c
is: C05512
initial amount: NaN
initial concentration: 1.0
name: Deoxyinosine
boundary condition: false
type: Species
is: HMDB00071
is: SBO:0000247
constant: false
notes: FORMULA: C10H12N4O4 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC01493 EHMN_ABBREVIATION: C05512
is: CHEBI:28997
has only substance units: false

metaR XOL27OHtm
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 1 AUTHORS: NOTES:unknown mechanism NJ
name: 27 hydroxy cholesterol transport
fast: false
is described by: ECO:0000000
reversible: true
type: Reaction
kinetic law: MODEL1310110045#
product: MODEL1310110045#
is: SBO:0000185
reactant: MODEL1310110045#

metaR FAOXC102C81m
kinetic law: MODEL1310110045#
product: MODEL1310110045#
reactant: MODEL1310110045#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C10:2-->C8:1)m
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110045#_3065adf5_689d_4629_8a65_d71eef8b6b01
is: SBO:0000252
initial concentration: NaN
name: ME3
constant: false
has only substance units: false
initial amount: NaN
is encoded by: hsa:10873
type: Species
is: Q6TCH8
boundary condition: true

metaM dhlam m
has only substance units: false
is: HMDB00985
type: Species
is: CHEBI:17694
is: SBO:0000247
name: dihydrolipoamide
initial concentration: 1.0
constant: false
initial amount: NaN
notes: FORMULA: C8H17NOS2 CHARGE: 0 INCHI: InChI=1S/C8H17NOS2/c9-8(10)4-2-1-3-7(12)5-6-11/h7,11-12H,1-6H2,(H2,9,10) HEPATONET_1.0_ABBREVIATION: HC00437 EHMN_ABBREVIATION: C00579
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110045#_c865b54c_12f6_4967_b6f9_9b56cb6c2418
constant: false
initial amount: NaN
is encoded by: hsa:6487
has only substance units: false
is: SBO:0000252
type: Species
boundary condition: true
initial concentration: NaN
name: ST3GAL3
is: Q5T4Y1

metaM ksi pre20 g
is: CHEBI:28067
name: keratan sulfate I biosynthesis, precursor 20
initial concentration: 1.0
is: SBO:0000247
initial amount: NaN
constant: false
notes: FORMULA: C171H274N12O140S6X CHARGE: -7
type: Species
has only substance units: false
boundary condition: false

metaR TMDPP
is version of: http://identifiers.org/ec-code/2.4.2.4
is: SBO:0000176
product: MODEL1310110045#
reversible: true
type: Reaction
is described by: ECO:0000269
kinetic law: MODEL1310110045#
notes: GENE_ASSOCIATION: (1890.1) SUBSYSTEM: Pyrimidine catabolism EC Number: 2.4.2.4 Confidence Level: 4 AUTHORS: PMID:7028324,PMID:718961,PMID:9693094 NOTES:
modifier: MODEL1310110045#
fast: false
name: thymidine phosphorylase
reactant: MODEL1310110045#

metaR RNDR1
reversible: false
modifier: MODEL1310110045#
is described by: ECO:0000254
notes: GENE_ASSOCIATION: (6240.1 and 6241.1) SUBSYSTEM: Nucleotide interconversion EC Number: 1.7.14.1 Confidence Level: 2 AUTHORS: PMID:14729598 NOTES:
name: ribonucleoside-diphosphate reductase (ADP)
reactant: MODEL1310110045#
kinetic law: MODEL1310110045#
product: MODEL1310110045#
fast: false
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.17.4.1
type: Reaction

metaR r0497
product: MODEL1310110045#
modifier: MODEL1310110045#
is version of: http://identifiers.org/ec-code/1.2.4.2
notes: GENE_ASSOCIATION: (4967.1) or (55753.1) SUBSYSTEM: Pyrimidine catabolism EC Number: 3.6.1.39 Confidence Level: 0 AUTHORS: PMID:1320895,PMID:6097526,PMID:6297538 NOTES:
fast: false
is: SBO:0000176
reactant: MODEL1310110045#
reversible: true
name: dTTP nucleotidohydrolase Pyrimidine metabolism EC:3.6.1.39
kinetic law: MODEL1310110045#
is described by: ECO:0000000
type: Reaction

metaM adp m
is: CHEBI:456216
initial concentration: 1.0
type: Species
name: ADP
is: SBO:0000247
initial amount: NaN
is: http://identifiers.org/pubchem.compound/3310
is: C00008
has only substance units: false
constant: false
is: HMDB01341
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110045#_29213f4e_ef5a_4756_a90c_659fbe03b65d
is encoded by: hsa:10905
name: MAN1A2
boundary condition: true
initial amount: NaN
is: SBO:0000252
constant: false
is: O60476
has only substance units: false
type: Species
initial concentration: NaN

metaR PPCDC
kinetic law: MODEL1310110045#
reversible: false
name: phosphopantothenoylcysteine decarboxylase
modifier: MODEL1310110045#
type: Reaction
is version of: http://identifiers.org/ec-code/4.1.1.36
is: SBO:0000176
is described by: ECO:0000269
reactant: MODEL1310110045#
fast: false
notes: GENE_ASSOCIATION: (60490.1) SUBSYSTEM: CoA synthesis EC Number: 4.1.1.36 Confidence Level: 4 AUTHORS: PMID:11923312 NOTES:
product: MODEL1310110045#

metaM n2m2mn l
initial amount: NaN
boundary condition: false
is: SBO:0000247
is: CHEBI:15428
is: HMDB00123
constant: false
type: Species
has only substance units: false
notes: FORMULA: C42H71N3O31 CHARGE: 0
initial concentration: 1.0
name: de-Fuc, reducing GlcNAc removed, de-Sia, de-Gal form of PA6 (w/o peptide linkage)

metaR MAL Lte
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
fast: false
product: MODEL1310110045#
type: Reaction
is described by: ECO:0000134
kinetic law: MODEL1310110045#
name: Transport of L-malate
is: SBO:0000185
reactant: MODEL1310110045#
reversible: true

metaR SPODMm
type: Reaction
name: superoxide dismutase
kinetic law: MODEL1310110045#
is described by: ECO:0000304
is: SBO:0000176
reactant: MODEL1310110045#
reversible: false
modifier: MODEL1310110045#
fast: false
is version of: http://identifiers.org/ec-code/1.15.1.1
notes: GENE_ASSOCIATION: (6648.1) SUBSYSTEM: ROS detoxification EC Number: 1.15.1.1 Confidence Level: 2 AUTHORS: PMID:12649272,PMID:9376114 NOTES:TV (8-15-2003)
product: MODEL1310110045#

metaR TYMSULT
is version of: http://identifiers.org/ec-code/2.8.2.1
name: Tyramine Sulfotransferase
is: SBO:0000176
reversible: false
product: MODEL1310110045#
notes: GENE_ASSOCIATION: (6818.3) or (6818.1) or (6817.4) or (6817.1) or (6817.3) or (6818.2) or (6817.2) or (6817.5) SUBSYSTEM: Tyrosine metabolism EC Number: 2.8.2.1 Confidence Level: 4 AUTHORS: PMID:11535246,PMID:15293241 NOTES:TV/RS (6/14/05)
is described by: ECO:0000269
type: Reaction
kinetic law: MODEL1310110045#
modifier: MODEL1310110045#
fast: false
reactant: MODEL1310110045#

metaM thyox L c
notes: FORMULA: C15H11I4NO4 CHARGE: 0 INCHI: InChI=1S/C15H11I4NO4/c16-8-4-7(5-9(17)13(8)21)24-14-10(18)1-6(2-11(14)19)3-12(20)15(22)23/h1-2,4-5,12,21H,3,20H2,(H,22,23)/t12-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00849
has only substance units: false
name: L-thyroxine
type: Species
initial amount: NaN
boundary condition: false
is: CHEBI:18332
constant: false
initial concentration: 1.0
is: SBO:0000247
is: HMDB00248

metaM din e
is: CHEBI:28997
initial concentration: 1.0
is: HMDB00071
is: C05512
type: Species
has only substance units: false
is: SBO:0000247
notes: FORMULA: C10H12N4O4 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC01493 EHMN_ABBREVIATION: C05512
boundary condition: false
initial amount: NaN
constant: false
name: Deoxyinosine

metaR ADA
is described by: ECO:0000269
product: MODEL1310110045#
reversible: false
modifier: MODEL1310110045#
reactant: MODEL1310110045#
is: SBO:0000176
kinetic law: MODEL1310110045#
fast: false
type: Reaction
notes: GENE_ASSOCIATION: (100.1) SUBSYSTEM: Purine catabolism EC Number: 3.5.4.4 Confidence Level: 4 AUTHORS: PMID:12381379,PMID:15016824 NOTES:Added EC- JLR
is version of: http://identifiers.org/ec-code/3.5.4.4
name: Adenosine deaminase

metaM pail5p hs c
is: SBO:0000247
initial concentration: 1.0
name: 1-phosphatidyl-1D-myo-inositol 5-phosphate(3-)
has only substance units: false
is: CHEBI:57795
type: Species
boundary condition: false
constant: false
initial amount: NaN
notes: FORMULA: C9H15O12P2FULLRCO2FULLR2CO2 CHARGE: -3

metaM adp n
is: HMDB01341
boundary condition: false
has only substance units: false
name: ADP(3-)
constant: false
initial concentration: 1.0
notes: FORMULA: C10H12N5O10P2 CHARGE: -3 INCHI: InChI=1S/C10H15N5O10P2/c11-8-5-9(13-2-12-8)15(3-14-5)10-7(17)6(16)4(24-10)1-23-27(21,22)25-26(18,19)20/h2-4,6-7,10,16-17H,1H2,(H,21,22)(H2,11,12,13)(H2,18,19,20)/p-3/t4-,6-,7-,10-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00018 EHMN_ABBREVIATION: C00008
is: CHEBI:456216
type: Species
is: SBO:0000247
initial amount: NaN

metaM atp r
is: C00002
boundary condition: false
initial amount: NaN
constant: false
type: Species
has only substance units: false
name: ATP(4-)
is: CHEBI:57299
is: SBO:0000247
is: HMDB00538
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110045#_1ea4f85a_f554_4006_b3f7_fc8e56636f01
initial concentration: NaN
constant: false
boundary condition: true
is: E2QRH8
is: SBO:0000252
name: PLCB4
is encoded by: hsa:5332
initial amount: NaN
has only substance units: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110045#_9a78af2a_8e1d_4117_952e_592e9aedbcbc
is: SBO:0000252
initial amount: NaN
has only substance units: false
is: Q5JWV8
constant: false
type: Species
boundary condition: true
initial concentration: NaN
is encoded by: hsa:2182
name: ACSL4

metaR EX thym LPAREN e RPAREN
kinetic law: MODEL1310110045#
reactant: MODEL1310110045#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Thymine exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110045#_2c181a21_2a29_4678_99a5_a0327676dce3
is encoded by: hsa:7296
is: Q16881
name: TXNRD1
initial amount: NaN
is: SBO:0000252
initial concentration: NaN
type: Species
constant: false
boundary condition: true
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110045#_bb0d72d2_e38e_456f_83c0_50423fbf63eb
constant: false
initial amount: NaN
is: Q7GXZ8
type: Species
boundary condition: true
is: SBO:0000252
name: COX2
is encoded by: hsa:4513
initial concentration: NaN
has only substance units: false

metaR r1164
is: SBO:0000176
reversible: false
is described by: ECO:0000000
product: MODEL1310110045#
reactant: MODEL1310110045#
name: EC:2.3.1.26
fast: false
kinetic law: MODEL1310110045#
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 2.3.1.26 Confidence Level: 0 AUTHORS: PMID:2760547,PMID:7822296,PMID:9242919 NOTES:
type: Reaction

metaR GALNTg
notes: GENE_ASSOCIATION: (26290.1) or (79695.1) or (2589.1) or (50614.1) or (8693.1) or (55568.2) or (114805.1) or (11226.1) or (117248.1) or (11227.1) or (55568.1) or (2590.1) or (51809.1) or (26290.1) or (79623.1) or (63917.1) or (2591.1) SUBSYSTEM: O-glycan synthesis EC Number: 2.4.1.41 Confidence Level: 0 AUTHORS: PMID:10767557,PMID:12417297,PMID:12507512,PMID:12634319,PMID:15147861,PMID:9765313 NOTES:NCD
type: Reaction
kinetic law: MODEL1310110045#
is version of: http://identifiers.org/ec-code/2.4.1.41
product: MODEL1310110045#
is: SBO:0000176
fast: false
reversible: false
is described by: ECO:0000000
reactant: MODEL1310110045#
name: GalNAc transferase, Golgi apparatus
modifier: MODEL1310110045#

http://identifiers.org/biomodels.db/MODEL1310110045#_7bfc12b6_a0b1_480e_bca3_67a0384b66e1
initial amount: NaN
is encoded by: hsa:11046
boundary condition: true
is: SBO:0000252
type: Species
is: Q76EJ3
initial concentration: NaN
name: SLC35D2
constant: false
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110045#_d632b807_4e1b_43eb_ad17_233b5531c9b3
type: Species
has only substance units: false
name: _T83654_1_m
boundary condition: true
constant: false
initial amount: NaN
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:T83654

metaR r2201
reactant: MODEL1310110045#
modifier: MODEL1310110045#
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.5
reversible: true
type: Reaction
notes: GENE_ASSOCIATION: (6566.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
fast: false
product: MODEL1310110045#
kinetic law: MODEL1310110045#
is: SBO:0000185
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110045#_b65f0b4e_d63f_4ed8_b698_d3efcbfed932
initial amount: NaN
has only substance units: false
is encoded by: hsa:2618
name: GART
constant: false
is: Q59HH3
initial concentration: NaN
is: SBO:0000252
boundary condition: true
type: Species

metaM cit c
is: C00158
boundary condition: false
is: SBO:0000247
name: Citrate
is: CHEBI:16947
initial concentration: 1.0
type: Species
notes: FORMULA: C6H5O7 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00153 EHMN_ABBREVIATION: C00158
is: HMDB00094
constant: false
has only substance units: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110045#_be252cd6_7a65_47e8_b564_8b0982c75c22
boundary condition: true
is: SBO:0000252
constant: false
is: Q15274
is encoded by: hsa:23475
initial concentration: NaN
type: Species
has only substance units: false
name: QPRT
initial amount: NaN

metaM h l
has only substance units: false
initial amount: NaN
boundary condition: false
is: http://identifiers.org/pubchem.compound/3380
name: proton
notes: FORMULA: H CHARGE: 1 INCHI: "
type: Species
initial concentration: 1.0
constant: false
is: CHEBI:24636
is: C00080
is: SBO:0000247

metaM 5adtststerones c
constant: false
initial amount: NaN
is: SBO:0000247
type: Species
notes: FORMULA: C19H29O5S CHARGE: -1 INCHI: InChI=1/C19H30O5S/c1-18-9-7-13(20)11-12(18)3-4-14-15-5-6-17(24-25(21,22)23)19(15,2)10-8-16(14)18/h12,14-17H,3-11H2,1-2H3,(H,21,22,23)/t12-,14-,15-,16-,17-,18-,19-/m0/s1 EHMN_ABBREVIATION: CE6032
has only substance units: false
boundary condition: false
name: 5alpha-Dihydrotestosterone sulfate
is: HMDB06278
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110045#_edf12c4b_4ea7_4077_95bf_98a9765cb7f0
has only substance units: false
constant: false
is encoded by: hsa:5315
is: P14618
initial amount: NaN
boundary condition: true
initial concentration: NaN
name: PKM2
is: SBO:0000252
type: Species

metaM ala B e
notes: FORMULA: C3H7NO2 CHARGE: 0 INCHI: InChI=1S/C3H7NO2/c4-2-1-3(5)6/h1-2,4H2,(H,5,6) HEPATONET_1.0_ABBREVIATION: HC00100
initial concentration: 1.0
has only substance units: false
is: CHEBI:16958
boundary condition: false
name: beta-alanine
constant: false
initial amount: NaN
is: HMDB00056
is: SBO:0000247
type: Species

http://identifiers.org/biomodels.db/MODEL1310110045#_12b54d7f_49b3_4c1a_9b95_c0682cf58270
is: Q9P0J0
has only substance units: false
is: SBO:0000252
boundary condition: true
initial amount: NaN
constant: false
is encoded by: hsa:51079
initial concentration: NaN
name: NDUFA13
type: Species

metaR RIBt
type: Reaction
kinetic law: MODEL1310110045#
is: SBO:0000185
is described by: ECO:0000000
product: MODEL1310110045#
name: ribose transport via diffusion
fast: false
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:15234337 NOTES:NCD
reactant: MODEL1310110045#

metaR EX nadp LPAREN e RPAREN
kinetic law: MODEL1310110045#
reactant: MODEL1310110045#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Nicotinamide adenine dinucleotide phosphate exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110045#_e5afda10_5aa8_4cf6_a492_774d4a80ac6b
name: PIK3CB:PIK3R1
boundary condition: true
type: Species
has part: B4DER4
initial concentration: NaN
has part: B3KT19
is: SBO:0000297
is encoded by: hsa:5295
constant: false
has only substance units: false
initial amount: NaN
is encoded by: hsa:5291

metaM CE5117 m
boundary condition: false
has only substance units: false
type: Species
name: (3E,5Z,8Z)-tetradecatrienoyl-CoA
is: SBO:0000247
constant: false
initial amount: NaN
initial concentration: 1.0
notes: FORMULA: C35H52N7O17P3S CHARGE: -4 INCHI: InChI=1/C35H56N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-26(44)63-19-18-37-25(43)16-17-38-33(47)30(46)35(2,3)21-56-62(53,54)59-61(51,52)55-20-24-29(58-60(48,49)50)28(45)34(57-24)42-23-41-27-31(36)39-22-40-32(27)42/h8-9,11-14,22-24,28-30,34,45-46H,4-7,10,15-21H2,1-3H3,(H,37,43)(H,38,47)(H,51,52)(H,53,54)(H2,36,39,40)(H2,48,49,50)/p-4/b9-8-,12-11-,14-13+/t24-,28+,29+,30u,34-/m0/s1 EHMN_ABBREVIATION: CE5117
is: CHEBI:57923

metaR LYStip
kinetic law: MODEL1310110045#
reactant: MODEL1310110045#
reversible: false
fast: false
name: L-lysine transport, peroxisomal (irreversible)
is described by: ECO:0000000
is: SBO:0000185
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: PMID:6811962 NOTES:MM
product: MODEL1310110045#

metaM pnto R e
initial concentration: 1.0
is: HMDB00210
type: Species
initial amount: NaN
is: SBO:0000247
constant: false
boundary condition: false
is: CHEBI:7916
notes: FORMULA: C9H16NO5 CHARGE: -1 INCHI: InChI=1S/C9H17NO5/c1-9(2,5-11)7(14)8(15)10-4-3-6(12)13/h7,11,14H,3-5H2,1-2H3,(H,10,15)(H,12,13) HEPATONET_1.0_ABBREVIATION: HC00568
name: (R)-Pantothenate
has only substance units: false

metaR ADNtm
is described by: ECO:0000269
type: Reaction
modifier: MODEL1310110045#
fast: false
product: MODEL1310110045#
kinetic law: MODEL1310110045#
is: SBO:0000185
name: adenosine facilated transport in mitochondria
reactant: MODEL1310110045#
notes: GENE_ASSOCIATION: (2030.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:10722669,PMID:12838422,PMID:14607828 NOTES:IT
reversible: true

metaR RE2625M
notes: GENE_ASSOCIATION: (1593.1) SUBSYSTEM: Bile acid synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:9660774 NOTES:
fast: false
type: Reaction
is: SBO:0000176
modifier: MODEL1310110045#
is described by: ECO:0000000
product: MODEL1310110045#
kinetic law: MODEL1310110045#
reversible: true
name: RE2625
is version of: http://identifiers.org/ec-code/1.14.13.15
reactant: MODEL1310110045#

metaR r2202
is described by: ECO:0000000
fast: false
modifier: MODEL1310110045#
product: MODEL1310110045#
type: Reaction
is: SBO:0000185
kinetic law: MODEL1310110045#
reversible: true
reactant: MODEL1310110045#
notes: GENE_ASSOCIATION: (6566.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.5

http://identifiers.org/biomodels.db/MODEL1310110045#_b6833e90_aec7_4899_ae0d_185aea3c678e
is encoded by: hsa:217
boundary condition: true
constant: false
is: P05091
name: ALDH2
type: Species
initial amount: NaN
has only substance units: false
is: SBO:0000252
initial concentration: NaN

metaR GARFT
fast: false
notes: GENE_ASSOCIATION: (2618.1) or (2618.2) SUBSYSTEM: Purine synthesis EC Number: 2.1.2.2 Confidence Level: 4 AUTHORS: PMID:12450384,PMID:2183217,PMID:9328467,PMID:9473452 NOTES:
kinetic law: MODEL1310110045#
product: MODEL1310110045#
modifier: MODEL1310110045#
reversible: true
name: phosphoribosylglycinamide formyltransferase
is described by: ECO:0000269
type: Reaction
is version of: http://identifiers.org/ec-code/2.1.2.2
reactant: MODEL1310110045#
is: SBO:0000176

metaM HC00361 c
constant: false
is: SBO:0000247
type: Species
notes: FORMULA: C7H12O13P2 CHARGE: -4 INCHI: InChI=1S/C7H16O13P2/c8-3(1-19-21(13,14)15)5(10)7(12)6(11)4(9)2-20-22(16,17)18/h3,5-8,10-12H,1-2H2,(H2,13,14,15)(H2,16,17,18)/p-4/t3-,5-,6-,7-/m1/s1 EHMN_ABBREVIATION: C00447
initial concentration: 1.0
boundary condition: false
is: CHEBI:58335
name: sedoheptulose 1,7-bisphosphate(4-)
has only substance units: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110045#_3e57ec10_d3e8_4ff1_8a50_b7d8cef67e07
is: Q11203
name: ST3GAL3
is: SBO:0000252
has only substance units: false
type: Species
initial concentration: NaN
initial amount: NaN
constant: false
is encoded by: hsa:6487
boundary condition: true

metaM h m
is: C00080
has only substance units: false
initial amount: NaN
name: proton
type: Species
constant: false
notes: FORMULA: H CHARGE: 1 INCHI: " HEPATONET_1.0_ABBREVIATION: HC00083 EHMN_ABBREVIATION: C00080
is: CHEBI:24636
is: SBO:0000247
boundary condition: false
is: http://identifiers.org/pubchem.compound/3380
initial concentration: 1.0

metaM adp x
constant: false
is: CHEBI:456216
has only substance units: false
is: SBO:0000247
type: Species
initial concentration: 1.0
initial amount: NaN
name: ADP(3-)
notes: FORMULA: C10H12N5O10P2 CHARGE: -3 INCHI: InChI=1S/C10H15N5O10P2/c11-8-5-9(13-2-12-8)15(3-14-5)10-7(17)6(16)4(24-10)1-23-27(21,22)25-26(18,19)20/h2-4,6-7,10,16-17H,1H2,(H,21,22)(H2,11,12,13)(H2,18,19,20)/p-3/t4-,6-,7-,10-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00018 EHMN_ABBREVIATION: C00008
boundary condition: false
is: HMDB01341

metaR FAOXC2251836m
is described by: ECO:0000000
reversible: false
is version of: http://identifiers.org/ec-code/1.3.8.1
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.3.99.3
type: Reaction
product: MODEL1310110045#
fast: false
kinetic law: MODEL1310110045#
notes: GENE_ASSOCIATION: (34.1) or (35.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.74 Confidence Level: 4 AUTHORS: NOTES:_2 rounds of beta-ox, plus a loss of 2 degrees of desatuartion, so no fad is oxidized peroxisomal (very long chain FA) c22:5,n-6 -> c18:3, n-6 - final '6' in abbreviation indicates omega6 FA 4 step FAO lumped for 2 rounds also includes EC 1.1.1.35, 1.1.1.211, 1.3.3.6, 4.2.1.17, 4.2.1.74 NJ
modifier: MODEL1310110045#
name: Beta oxidation of fatty acid
reactant: MODEL1310110045#

http://identifiers.org/biomodels.db/MODEL1310110045#_cad161ce_094e_4009_a8ad_2ed865eb2463
initial concentration: NaN
has only substance units: false
is: SBO:0000252
is encoded by: hsa:6514
constant: false
initial amount: NaN
boundary condition: true
is: P11168
name: SLC2A2
type: Species

metaR EX 3mob LPAREN e RPAREN
kinetic law: MODEL1310110045#
reactant: MODEL1310110045#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: Exchange of 3-methyl-2-oxobutanoate
type: Reaction

metaR AKR1D
name: aldo-keto reductase family 1, member D1 (delta 4-3-ketosteroid-5-beta-reductase)
kinetic law: MODEL1310110045#
notes: GENE_ASSOCIATION: (6718.1) SUBSYSTEM: Bile acid synthesis EC Number: 1.3.99.6 Confidence Level: 4 AUTHORS: NOTES:refs: uniprot, KEGG DW Russell bile acid synthesis review paper (see human recon journal citations) NJ
product: MODEL1310110045#
is described by: ECO:0000269
reversible: false
modifier: MODEL1310110045#
fast: false
is: SBO:0000176
reactant: MODEL1310110045#
type: Reaction
is version of: http://identifiers.org/ec-code/1.3.1.3

metaM 5adtststerones e
is: SBO:0000247
type: Species
notes: FORMULA: C19H29O5S CHARGE: -1 INCHI: InChI=1/C19H30O5S/c1-18-9-7-13(20)11-12(18)3-4-14-15-5-6-17(24-25(21,22)23)19(15,2)10-8-16(14)18/h12,14-17H,3-11H2,1-2H3,(H,21,22,23)/t12-,14-,15-,16-,17-,18-,19-/m0/s1 EHMN_ABBREVIATION: CE6032
boundary condition: false
has only substance units: false
name: 5alpha-Dihydrotestosterone sulfate
is: HMDB06278
constant: false
initial concentration: 1.0
initial amount: NaN

metaR MANter
type: Reaction
is: SBO:0000185
reactant: MODEL1310110045#
name: mannose efflux from endoplasmic reticulum
reversible: false
kinetic law: MODEL1310110045#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD
fast: false
is described by: ECO:0000000
product: MODEL1310110045#

metaR r0340
is version of: http://identifiers.org/ec-code/1.3.1.38
name: ATP:(R)-glycerate 3-phosphotransferase Glycine, serine and threonine metabolism EC:2.7.1.31
reversible: false
product: MODEL1310110045#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (AA526438.1) or (H17063.1) or (51102.1) or (55825.1) SUBSYSTEM: Unassigned EC Number: 2.7.1.31 Confidence Level: 0 AUTHORS: PMID:16753811,PMID:216417,PMID:2537226,PMID:6252205 NOTES:
kinetic law: MODEL1310110045#
reactant: MODEL1310110045#
modifier: MODEL1310110045#
type: Reaction
is: SBO:0000176
fast: false

metaM h n
boundary condition: false
is: SBO:0000247
has only substance units: false
is: CHEBI:24636
initial amount: NaN
name: proton
notes: FORMULA: H CHARGE: 1 INCHI: InChI=1S/p+1/i/hH HEPATONET_1.0_ABBREVIATION: HC00083 EHMN_ABBREVIATION: C00080
initial concentration: 1.0
constant: false
type: Species

metaR SBTR
fast: false
reversible: false
is version of: http://identifiers.org/ec-code/1.1.1.2
is described by: ECO:0000269
type: Reaction
notes: GENE_ASSOCIATION: (8574.1) or (10327.1) or (231.1) or (10327.2) SUBSYSTEM: Fructose and mannose metabolism EC Number: 1.1.1.21 Confidence Level: 4 AUTHORS: PMID:12071861,PMID:9823300 NOTES:
modifier: MODEL1310110045#
name: D-sorbitol reductase
kinetic law: MODEL1310110045#
reactant: MODEL1310110045#
is: SBO:0000176
product: MODEL1310110045#
is version of: http://identifiers.org/ec-code/1.1.1.21

metaR r2200
is described by: ECO:0000000
modifier: MODEL1310110045#
fast: false
product: MODEL1310110045#
kinetic law: MODEL1310110045#
reversible: true
type: Reaction
notes: GENE_ASSOCIATION: (6566.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
is: SBO:0000185
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.5
reactant: MODEL1310110045#

metaM rib D c
is: SBO:0000247
initial concentration: 1.0
has only substance units: false
name: D-ribose
notes: FORMULA: C5H10O5 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00119
boundary condition: false
initial amount: NaN
is: CHEBI:16988
is: HMDB00283
type: Species
constant: false

metaM pnto R c
is: HMDB00210
type: Species
initial amount: NaN
is: SBO:0000247
boundary condition: false
notes: FORMULA: C9H16NO5 CHARGE: -1 INCHI: InChI=1S/C9H17NO5/c1-9(2,5-11)7(14)8(15)10-4-3-6(12)13/h7,11,14H,3-5H2,1-2H3,(H,10,15)(H,12,13) HEPATONET_1.0_ABBREVIATION: HC00568
constant: false
name: (R)-Pantothenate
has only substance units: false
is: CHEBI:7916
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110045#_e4aac345_08c5_4710_813d_8bb8afeec4e7
initial amount: NaN
initial concentration: NaN
has only substance units: false
name: SCD5
constant: false
boundary condition: true
type: Species
is: SBO:0000252
is encoded by: hsa:79966
is: Q86SK9

http://identifiers.org/biomodels.db/MODEL1310110045#_92b853d0_84ad_4bbd_b786_218aece7d52c
has only substance units: false
initial amount: NaN
type: Species
is: P09923
constant: false
is: SBO:0000252
initial concentration: NaN
boundary condition: true
is encoded by: hsa:248
name: ALPI

metaR NACHEX25ly
name: beta-N-acetylhexosaminidase, lysosomal
type: Reaction
is: SBO:0000176
reversible: false
product: MODEL1310110045#
notes: GENE_ASSOCIATION: (3073.1 and 3074.1) or (3073.1) or (3074.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.52 Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12706724,PMID:8993162 NOTES:NCD
fast: false
modifier: MODEL1310110045#
is version of: http://identifiers.org/ec-code/3.2.1.52
kinetic law: MODEL1310110045#
reactant: MODEL1310110045#
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110045#_e0d7a906_2a95_45e5_bf22_91a7225a864d
is: SBO:0000252
initial amount: NaN
type: Species
boundary condition: true
name: NDUFS7
is: O75251
is encoded by: hsa:374291
has only substance units: false
constant: false
initial concentration: NaN

metaM ksii core4 g
constant: false
boundary condition: false
name: keratan sulfate II (core 4-linked)
is: SBO:0000247
has only substance units: false
initial amount: NaN
is: CHEBI:17140
type: Species
initial concentration: 1.0
notes: FORMULA: C89H142N7O72S3X CHARGE: -4
is: HMDB01644

metaM xol25oh r
has only substance units: false
is: HMDB06247
notes: FORMULA: C27H46O2 CHARGE: 0 INCHI: InChI=1S/C27H46O2/c1-18(7-6-14-25(2,3)29)22-10-11-23-21-9-8-19-17-20(28)12-15-26(19,4)24(21)13-16-27(22,23)5/h8,18,20-24,28-29H,6-7,9-17H2,1-5H3/t18-,20+,21+,22-,23+,24+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01146
is: SBO:0000247
initial amount: NaN
name: 25-hydroxycholesterol
initial concentration: 1.0
is: CHEBI:42977
type: Species
boundary condition: false
constant: false

metaM dttp n
initial amount: NaN
has only substance units: false
type: Species
is: CHEBI:37568
notes: FORMULA: C10H13N2O14P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00368 EHMN_ABBREVIATION: C00459
is: SBO:0000247
boundary condition: false
is: C00459
is: HMDB01342
initial concentration: 1.0
constant: false
name: dTTP

http://identifiers.org/biomodels.db/MODEL1310110045#_9e8bb045_523b_4ddc_88cc_584c90f0a795
has only substance units: false
constant: false
is encoded by: hsa:AI972237
boundary condition: true
type: Species
initial concentration: NaN
name: _AI972237_1_c
is: SBO:0000252
initial amount: NaN

metaM mi1p D c
notes: FORMULA: C6H11O9P CHARGE: -2 INCHI: InChI=1S/C6H13O9P/c7-1-2(8)4(10)6(5(11)3(1)9)15-16(12,13)14/h1-11H,(H2,12,13,14)/p-2/t1-,2-,3+,4-,5-,6-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00698
type: Species
name: 1D-myo-inositol 1-phosphate(2-)
initial concentration: 1.0
boundary condition: false
initial amount: NaN
is: HMDB02985
has only substance units: false
constant: false
is: SBO:0000247
is: CHEBI:58433

metaR ACHEe
modifier: MODEL1310110045#
type: Reaction
notes: GENE_ASSOCIATION: (43.1) or (43.2) SUBSYSTEM: Glycerophospholipid metabolism EC Number: 3.1.1.7 Confidence Level: 4 AUTHORS: PMID:11283752,PMID:1517212 NOTES:NJ
reactant: MODEL1310110045#
kinetic law: MODEL1310110045#
fast: false
is: SBO:0000176
is described by: ECO:0000269
product: MODEL1310110045#
reversible: false
is version of: http://identifiers.org/ec-code/3.1.1.7
name: Acetylcholinesterase

metaM crm hs c
name: N-acylsphingosine
constant: false
initial concentration: 1.0
has only substance units: false
notes: FORMULA: C18H36NO2FULLRCO CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC01990 EHMN_ABBREVIATION: C00195
is: SBO:0000247
is: CHEBI:52639
initial amount: NaN
boundary condition: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110045#_4e279909_2b0e_4922_b0b9_24db19bef214
is: O95395
constant: false
has only substance units: false
initial concentration: NaN
type: Species
name: GCNT3
initial amount: NaN
is: SBO:0000252
is encoded by: hsa:9245
boundary condition: true

metaM 2hexdtricoa m
is: HMDB02288
initial concentration: 1.0
name: 2,7,10-hexadecatrienoylcoa
has only substance units: false
is: SBO:0000247
constant: false
type: Species
initial amount: NaN
notes: FORMULA: C37H56N7O17P3S CHARGE: -4
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110045#_4d9e6b39_ba4f_4159_8865_1159627cc822
name: SLCO2A1
type: Species
has only substance units: false
initial concentration: NaN
is: SBO:0000252
boundary condition: true
constant: false
is: Q92959
initial amount: NaN
is encoded by: hsa:6578

metaM orot c
is: HMDB00226
name: Orotate
initial amount: NaN
boundary condition: false
is: C00295
notes: FORMULA: C5H3N2O4 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00256 EHMN_ABBREVIATION: C00295
is: CHEBI:30839
type: Species
has only substance units: false
constant: false
is: SBO:0000247
initial concentration: 1.0

metaM acald c
name: acetaldehyde
is: HMDB00990
constant: false
type: Species
is: SBO:0000247
has only substance units: false
is: CHEBI:15343
notes: FORMULA: C2H4O CHARGE: 0 INCHI: InChI=1S/C2H4O/c1-2-3/h2H,1H3 HEPATONET_1.0_ABBREVIATION: HC00087 EHMN_ABBREVIATION: C00084
boundary condition: false
initial concentration: 1.0
initial amount: NaN

metaM rib D e
is: SBO:0000247
has only substance units: false
notes: FORMULA: C5H10O5 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00119
initial concentration: 1.0
initial amount: NaN
is: CHEBI:16988
name: D-ribose
type: Species
boundary condition: false
constant: false
is: HMDB00283

http://identifiers.org/biomodels.db/MODEL1310110045#_83422e6f_a4d8_40ed_839a_9b53b20b6fca
initial amount: NaN
name: AKR1B1
is: P15121
is encoded by: hsa:231
boundary condition: true
initial concentration: NaN
has only substance units: false
is: SBO:0000252
constant: false
type: Species

metaR GLNS
reversible: false
product: MODEL1310110045#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/4.1.1.15
type: Reaction
reactant: MODEL1310110045#
kinetic law: MODEL1310110045#
name: glutamine synthetase
notes: GENE_ASSOCIATION: (2752.1) or (51557.1) SUBSYSTEM: Glutamate metabolism EC Number: Confidence Level: 2 AUTHORS: NOTES:
fast: false
is described by: ECO:0000254
modifier: MODEL1310110045#

metaR r0779
is version of: http://identifiers.org/ec-code/4.2.1.17
name: 3-Hydroxy-2-methylpropanoyl-CoA hydrolase EC:3.1.2.4
is version of: http://identifiers.org/ec-code/1.1.1.35
modifier: MODEL1310110045#
reactant: MODEL1310110045#
product: MODEL1310110045#
notes: GENE_ASSOCIATION: (1892.1) or (1962.1) or (3030.1) SUBSYSTEM: Unassigned EC Number: 3.1.2.4 Confidence Level: 0 AUTHORS: PMID:11580916,PMID:8188708 NOTES:
type: Reaction
fast: false
reversible: false
is: SBO:0000176
is described by: ECO:0000000
kinetic law: MODEL1310110045#

metaM atp x
initial amount: NaN
is: C00002
name: ATP(4-)
is: HMDB00538
is: CHEBI:57299
has only substance units: false
initial concentration: 1.0
is: SBO:0000247
boundary condition: false
type: Species
constant: false

metaR UMPK3n
fast: false
reactant: MODEL1310110045#
product: MODEL1310110045#
is described by: ECO:0000269
is: SBO:0000176
reversible: true
name: UMP kinase (UTP),nuclear
type: Reaction
kinetic law: MODEL1310110045#
is version of: http://identifiers.org/ec-code/2.7.4.14
modifier: MODEL1310110045#
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:

metaM h r
type: Species
is: C00080
name: proton
is: http://identifiers.org/pubchem.compound/3380
initial concentration: 1.0
is: SBO:0000247
notes: FORMULA: H CHARGE: 1 INCHI: " HEPATONET_1.0_ABBREVIATION: HC00083 EHMN_ABBREVIATION: C00080
is: CHEBI:24636
boundary condition: false
has only substance units: false
constant: false
initial amount: NaN

metaM ksii core4 e
name: keratan sulfate II (core 4-linked)
constant: false
has only substance units: false
is: HMDB00211
is: CHEBI:17268
is: SBO:0000247
type: Species
notes: FORMULA: C89H142N7O72S3X CHARGE: -4
initial amount: NaN
initial concentration: 1.0
boundary condition: false

metaM acetol c
name: hydroxyacetone
constant: false
is: HMDB06961
is: CHEBI:27957
type: Species
has only substance units: false
boundary condition: false
initial amount: NaN
notes: FORMULA: C3H6O2 CHARGE: 0 INCHI: InChI=1S/C3H6O2/c1-3(5)2-4/h4H,2H2,1H3
initial concentration: 1.0
is: SBO:0000247

metaM retn r
has only substance units: false
boundary condition: false
constant: false
notes: FORMULA: C20H27O2 CHARGE: -1 INCHI: InChI=1S/C20H28O2/c1-15(8-6-9-16(2)14-19(21)22)11-12-18-17(3)10-7-13-20(18,4)5/h6,8-9,11-12,14H,7,10,13H2,1-5H3,(H,21,22)/p-1/b9-6+,12-11+,15-8+,16-14+ HEPATONET_1.0_ABBREVIATION: HC00532 EHMN_ABBREVIATION: C00777
initial amount: NaN
is: CHEBI:35291
is: SBO:0000247
type: Species
initial concentration: 1.0
is: HMDB01852
name: all-trans-retinoate

metaR LNLCCRNt
fast: false
name: transport into the mitochondria (carnitine)
is: SBO:0000185
reactant: MODEL1310110045#
is described by: ECO:0000269
modifier: MODEL1310110045#
reversible: false
kinetic law: MODEL1310110045#
product: MODEL1310110045#
notes: GENE_ASSOCIATION: (788.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: NOTES:NJ
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110045#_9e4fbb70_7152_4077_8d43_fe542c15a2f3
initial concentration: NaN
is: B7Z6Q4
is encoded by: hsa:3612
boundary condition: true
initial amount: NaN
has only substance units: false
is: SBO:0000252
constant: false
type: Species
name: IMPA1

metaM crm hs e
constant: false
name: N-acylsphingosine
initial concentration: 1.0
is: SBO:0000247
is: CHEBI:52639
initial amount: NaN
has only substance units: false
notes: FORMULA: C18H36NO2FULLRCO CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC01990 EHMN_ABBREVIATION: C00195
boundary condition: false
type: Species

metaM cit e
constant: false
boundary condition: false
has only substance units: false
name: citrate(3-)
notes: FORMULA: C6H5O7 CHARGE: -3 INCHI: InChI=1S/C6H8O7/c7-3(8)1-6(13,5(11)12)2-4(9)10/h13H,1-2H2,(H,7,8)(H,9,10)(H,11,12)/p-3 HEPATONET_1.0_ABBREVIATION: HC00153 EHMN_ABBREVIATION: C00158
initial amount: NaN
type: Species
initial concentration: 1.0
is: SBO:0000247
is: CHEBI:16947
is: HMDB00094

metaR GALt1r
name: galactose transport (uniport)
modifier: MODEL1310110045#
notes: GENE_ASSOCIATION: (29988.1) or (6513.1) or (6515.1) or (6514.1) or (81031.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10421229,PMID:10821868,PMID:10860996,PMID:11247674,PMID:11592815,PMID:11882499,PMID:12135767,PMID:12750891,PMID:1701966,PMID:2182619,PMID:3103217,PMID:3170580,PMID:3399500,PMID:3839598,PMID:7926364,PMID:8504756,PMID:9230074,PMID:9770484 NOTES:NCD
is: SBO:0000185
reactant: MODEL1310110045#
is described by: ECO:0000269
type: Reaction
product: MODEL1310110045#
kinetic law: MODEL1310110045#
reversible: true
fast: false

http://identifiers.org/biomodels.db/MODEL1310110045#_d2f804f2_9fec_4b62_8235_e669d36ee1e9
is: SBO:0000252
has only substance units: false
boundary condition: true
name: PECR
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:55825
type: Species
constant: false
is: Q9BY49

metaM damp c
initial amount: NaN
notes: FORMULA: C10H12N5O6P CHARGE: -2 INCHI: InChI=1S/C10H14N5O6P/c11-9-8-10(13-3-12-9)15(4-14-8)7-1-5(16)6(21-7)2-20-22(17,18)19/h3-7,16H,1-2H2,(H2,11,12,13)(H2,17,18,19)/p-2/t5-,6+,7+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00304 EHMN_ABBREVIATION: C00360
name: dAMP(2-)
is: CHEBI:58245
constant: false
boundary condition: false
initial concentration: 1.0
is: HMDB00905
type: Species
has only substance units: false
is: SBO:0000247

metaR PROSTGE2t
notes: GENE_ASSOCIATION: (28231.1) or (6578.1) or (28232.1) or (6579.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12507753,PMID:8787677,PMID:9334206 NOTES:NJ
reversible: true
fast: false
kinetic law: MODEL1310110045#
type: Reaction
is described by: ECO:0000269
reactant: MODEL1310110045#
modifier: MODEL1310110045#
name: prostaglandin transport via bicarbonate countertransport
is: SBO:0000185
product: MODEL1310110045#

metaM dttp m
has only substance units: false
is: SBO:0000247
is: C00459
is: HMDB01342
is: CHEBI:37568
constant: false
boundary condition: false
type: Species
name: dTTP
notes: FORMULA: C10H13N2O14P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00368 EHMN_ABBREVIATION: C00459
initial amount: NaN
initial concentration: 1.0

metaM orot e
notes: FORMULA: C5H3N2O4 CHARGE: -1 INCHI: InChI=1S/C5H4N2O4/c8-3-1-2(4(9)10)6-5(11)7-3/h1H,(H,9,10)(H2,6,7,8,11)/p-1 HEPATONET_1.0_ABBREVIATION: HC00256 EHMN_ABBREVIATION: C00295
boundary condition: false
is: CHEBI:30839
name: orotate
type: Species
constant: false
is: SBO:0000247
has only substance units: false
initial concentration: 1.0
is: HMDB00226
initial amount: NaN

metaR EX h2o2 LPAREN e RPAREN
kinetic law: MODEL1310110045#
reactant: MODEL1310110045#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Hydrogen peroxide exchange
type: Reaction

metaR FAOXC180
kinetic law: MODEL1310110045#
notes: GENE_ASSOCIATION: (34.1) or (34.1) or (35.1) or (35.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.99.3 Confidence Level: 4 AUTHORS: PMID:2565344,PMID:3035565 NOTES:TV Other enzymes: 1.3.3.6, 4.2.1.74, 4.2.1.17, 1.1.1.35, 1.1.1.211
reversible: false
is version of: http://identifiers.org/ec-code/1.3.99.3
is version of: http://identifiers.org/ec-code/1.3.8.1
product: MODEL1310110045#
is described by: ECO:0000269
is: SBO:0000176
name: Beta oxidation of long chain fatty acid
modifier: MODEL1310110045#
type: Reaction
reactant: MODEL1310110045#
fast: false

metaM docosahexcoa m
notes: FORMULA: C43H62N7O17P3S CHARGE: -4
boundary condition: false
name: 3,7,10,13,16,19-docosahexenoylcoa
initial concentration: 1.0
constant: false
initial amount: NaN
type: Species
is: HMDB06294
has only substance units: false
is: SBO:0000247

metaR AG13T9g
product: MODEL1310110045#
is version of: http://identifiers.org/ec-code/2.4.1.149
is described by: ECO:0000000
kinetic law: MODEL1310110045#
fast: false
reversible: false
name: N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase, Golgi apparatus
notes: GENE_ASSOCIATION: (146712.1) or (79369.1) or (10331.1) or (374907.1) or (10678.2) or (374907.2) or (10678.1) or (11041.1) or (93010.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.149 Confidence Level: 4 AUTHORS: PMID:10747980,PMID:11042166,PMID:12061784,PMID:12512857,PMID:15560372,PMID:15620693,PMID:9405606 NOTES:NCD
modifier: MODEL1310110045#
type: Reaction
reactant: MODEL1310110045#
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110045#_9dd08713_e16b_4697_93e0_59a769873e36
initial amount: NaN
boundary condition: true
is encoded by: hsa:219
is: P30837
type: Species
initial concentration: NaN
is: SBO:0000252
has only substance units: false
constant: false
name: ALDH1B1

http://identifiers.org/biomodels.db/MODEL1310110045#_91a6e8be_6120_43b1_a1da_e840c29d4282
boundary condition: true
is: SBO:0000252
is: P46721
initial amount: NaN
is encoded by: hsa:6579
constant: false
initial concentration: NaN
type: Species
name: SLCO1A2
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110045#_6956b027_7efa_4102_8cc1_30efff80b15d
constant: false
is: Q92685
initial amount: NaN
name: ALG3
is: SBO:0000252
type: Species
has only substance units: false
is encoded by: hsa:10195
boundary condition: true
initial concentration: NaN

metaM ksii core2 pre4 g
is: C00130
boundary condition: false
has only substance units: false
initial concentration: 1.0
type: Species
notes: FORMULA: C53H86N4O38X CHARGE: -1
is: HMDB00175
name: keratan sulfate II biosynthesis, precursor 4
is: SBO:0000247
initial amount: NaN
is: CHEBI:58053
constant: false

metaM xyl D c
is: SBO:0000247
has only substance units: false
constant: false
initial amount: NaN
name: aldehydo-D-xylose
notes: FORMULA: C5H10O5 CHARGE: 0 INCHI: InChI=1S/C5H10O5/c6-1-3(8)5(10)4(9)2-7/h1,3-5,7-10H,2H2/t3-,4+,5+/m0/s1
initial concentration: 1.0
boundary condition: false
is: CHEBI:15936
type: Species

metaM dgtp n
name: dGTP
is: HMDB01440
type: Species
has only substance units: false
constant: false
is: CHEBI:16497
initial concentration: 1.0
initial amount: NaN
is: SBO:0000247
is: C00286
notes: FORMULA: C10H12N5O13P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00252 EHMN_ABBREVIATION: C00286
boundary condition: false

metaM orn m
is: SBO:0000247
is: C01602
initial concentration: 1.0
type: Species
is: CHEBI:46912
has only substance units: false
boundary condition: false
notes: FORMULA: C5H13N2O2 CHARGE: 1
constant: false
name: Ornithine
is: HMDB00214
initial amount: NaN

metaR RE3524R
notes: GENE_ASSOCIATION: SUBSYSTEM: Eicosanoid metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:9755286 NOTES:
type: Reaction
reversible: true
kinetic law: MODEL1310110045#
name: RE3524
fast: false
reactant: MODEL1310110045#
is: SBO:0000176
is described by: ECO:0000000
product: MODEL1310110045#

metaR r2385
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
fast: false
reactant: MODEL1310110045#
kinetic law: MODEL1310110045#
modifier: MODEL1310110045#
is: SBO:0000185
is described by: ECO:0000000
reversible: false
notes: GENE_ASSOCIATION: (215.1) or (U52111.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172 NOTES:
product: MODEL1310110045#
type: Reaction

metaM ppcoa m
type: Species
initial amount: NaN
has only substance units: false
boundary condition: false
name: Propanoyl-CoA
is: C00100
constant: false
is: CHEBI:57392
is: HMDB01275
initial concentration: 1.0
notes: FORMULA: C24H36N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00101 EHMN_ABBREVIATION: C00100
is: SBO:0000247

metaR EX adprbp LPAREN e RPAREN
kinetic law: MODEL1310110045#
reactant: MODEL1310110045#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: ADPribose 2'-phosphate exchange
type: Reaction

metaR Asn X Ser Thrtr
name: Asn-X-Ser/Thr transport (from ER to lysosome)
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: PMID:10823827,PMID:12845534 NOTES:
fast: false
is described by: ECO:0000269
reactant: MODEL1310110045#
type: Reaction
product: MODEL1310110045#
kinetic law: MODEL1310110045#
reversible: true
is: SBO:0000185

metaM amp x
is: C00020
has only substance units: false
name: AMP
is: CHEBI:456215
is: HMDB00045
type: Species
initial concentration: 1.0
constant: false
initial amount: NaN
notes: FORMULA: C10H12N5O7P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00030 EHMN_ABBREVIATION: C00020
is: SBO:0000247
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110045#_e24c8c78_b144_43d0_90dc_26a06b5a27a3
is: P30084
has only substance units: false
initial concentration: NaN
boundary condition: true
constant: false
is: SBO:0000252
is encoded by: hsa:1892
name: ECHS1
initial amount: NaN
type: Species

http://identifiers.org/biomodels.db/MODEL1310110045#_35bdc915_b302_4da3_8268_64256a3411f0
initial concentration: NaN
constant: false
name: ALDOC
has only substance units: false
is: P09972
initial amount: NaN
type: Species
is: SBO:0000252
is encoded by: hsa:230
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110045#_a0f4b87c_427e_4abd_88ff_ec056ba36d0e
has only substance units: false
type: Species
is: P05062
boundary condition: true
name: ALDOB
initial amount: NaN
initial concentration: NaN
constant: false
is encoded by: hsa:229
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110045#_790f76b7_ba5c_48ef_b51f_4507bb8313b5
type: Species
name: NDUFB2
is encoded by: hsa:4708
constant: false
has only substance units: false
is: H7C5B8
is: SBO:0000252
boundary condition: true
initial amount: NaN
initial concentration: NaN

metaR r2384
notes: GENE_ASSOCIATION: (215.1) or (U52111.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172 NOTES:
product: MODEL1310110045#
modifier: MODEL1310110045#
is described by: ECO:0000000
fast: false
kinetic law: MODEL1310110045#
reactant: MODEL1310110045#
is: SBO:0000185
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
type: Reaction
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110045#_374ff323_49ef_4482_b1ed_ee9a573bc885
is encoded by: hsa:51727
constant: false
has only substance units: false
is: SBO:0000252
initial amount: NaN
initial concentration: NaN
is: B2R6S5
boundary condition: true
type: Species
name: CMPK1

metaR EX ha LPAREN e RPAREN
kinetic law: MODEL1310110045#
reactant: MODEL1310110045#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: hyaluronan exchange
type: Reaction

metaR GLXO2p
product: MODEL1310110045#
kinetic law: MODEL1310110045#
modifier: MODEL1310110045#
fast: false
is: SBO:0000176
reversible: false
name: glyoxylate oxidase, peroxisomal
type: Reaction
is version of: http://identifiers.org/ec-code/1.1.3.15
notes: GENE_ASSOCIATION: (54363.1) or (51179.2) or (51179.1) SUBSYSTEM: Glyoxylate and dicarboxylate metabolism EC Number: 1.1.3.15 Confidence Level: 4 AUTHORS: PMID:10777549,PMID:4705431,PMID:9038835 NOTES:NCD
reactant: MODEL1310110045#
is described by: ECO:0000269

metaR THMMPtm
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: PMID:12014993,PMID:9755848 NOTES:IT
product: MODEL1310110045#
fast: false
reactant: MODEL1310110045#
is described by: ECO:0000000
name: Thiamine monophosphate transport, mitochondrial
reversible: true
kinetic law: MODEL1310110045#
type: Reaction

metaM 3mlda c
name: 3-Methylimidazoleacetic acid
boundary condition: false
constant: false
type: Species
is: SBO:0000247
notes: FORMULA: C6H7N2O2 CHARGE: -1 INCHI: InChI=1/C6H8N2O2/c1-8-3-5(7-4-8)2-6(9)10/h3-4H,2H2,1H3,(H,9,10) EHMN_ABBREVIATION: C05828
initial concentration: 1.0
is: C05828
is: http://identifiers.org/pubchem.compound/8122
initial amount: NaN
has only substance units: false
is: HMDB02820

metaM lnlncgcoa r
type: Species
has only substance units: false
boundary condition: false
initial amount: NaN
notes: FORMULA: C39H60N7O17P3S CHARGE: -4 INCHI: InChI=1S/C39H64N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-30(48)67-23-22-41-29(47)20-21-42-37(51)34(50)39(2,3)25-60-66(57,58)63-65(55,56)59-24-28-33(62-64(52,53)54)32(49)38(61-28)46-27-45-31-35(40)43-26-44-36(31)46/h8-9,11-12,14-15,26-28,32-34,38,49-50H,4-7,10,13,16-25H2,1-3H3,(H,41,47)(H,42,51)(H,55,56)(H,57,58)(H2,40,43,44)(H2,52,53,54)/p-4/b9-8-,12-11-,15-14-/t28-,32-,33-,34+,38-/m1/s1 EHMN_ABBREVIATION: C03035
initial concentration: 1.0
is: SBO:0000247
name: gamma-linolenoyl-CoA(4-)
is: CHEBI:57363
is: HMDB06368
constant: false

http://identifiers.org/biomodels.db/MODEL1310110045#_a9152b17_70de_4755_b1be_d7d156d2adeb
is: SBO:0000252
boundary condition: true
has only substance units: false
constant: false
name: GALT
initial amount: NaN
initial concentration: NaN
is: B2RAT6
type: Species
is encoded by: hsa:2592

metaM adrncoa c
is: SBO:0000247
has only substance units: false
name: adrenyl coenzyme A
constant: false
notes: FORMULA: C43H66N7O17P3S CHARGE: -4 INCHI: InChI=1/C43H70N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-34(52)71-27-26-45-33(51)24-25-46-41(55)38(54)43(2,3)29-64-70(61,62)67-69(59,60)63-28-32-37(66-68(56,57)58)36(53)42(65-32)50-31-49-35-39(44)47-30-48-40(35)50/h8-9,11-12,14-15,17-18,30-32,36-38,42,53-54H,4-7,10,13,16,19-29H2,1-3H3,(H,45,51)(H,46,55)(H,59,60)(H,61,62)(H2,44,47,48)(H2,56,57,58)/b9-8-,12-11-,15-14-,18-17-/t32-,36-,37-,38?,42-/m1/s1
is: C16170
is: http://identifiers.org/pubchem.compound/47205480
type: Species
boundary condition: false
initial amount: NaN
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110045#_acfb33f4_13fd_4e77_892b_72901dd7e04e
has only substance units: false
is: SBO:0000252
type: Species
initial amount: NaN
is encoded by: hsa:2348
initial concentration: NaN
name: FOLR1
boundary condition: true
constant: false

metaR PHYCBOXL
kinetic law: MODEL1310110045#
fast: false
is described by: ECO:0000212
is version of: http://identifiers.org/ec-code/4.1.1.28
name: L-Phenylalanine carboxy-lyase
reversible: false
type: Reaction
is: SBO:0000176
reactant: MODEL1310110045#
product: MODEL1310110045#
notes: GENE_ASSOCIATION: (1644.1) SUBSYSTEM: Phenylalanine metabolism EC Number: 4.1.1.28 Confidence Level: 1 AUTHORS: NOTES:SAB
modifier: MODEL1310110045#

metaM ppi n
has only substance units: false
initial amount: NaN
type: Species
constant: false
is: CHEBI:33019
is: HMDB00250
initial concentration: 1.0
is: SBO:0000247
notes: FORMULA: HO7P2 CHARGE: -3 INCHI: InChI=1S/H4O7P2/c1-8(2,3)7-9(4,5)6/h(H2,1,2,3)(H2,4,5,6)/p-3 HEPATONET_1.0_ABBREVIATION: HC00023 EHMN_ABBREVIATION: C00013
boundary condition: false
name: diphosphate(3-)

http://identifiers.org/biomodels.db/MODEL1310110045#_508148ab_ca9d_4926_a1d0_c5b81f5a4db1
type: Species
is: Q5K4L6
boundary condition: true
name: SLC27A3
constant: false
initial concentration: NaN
is encoded by: hsa:11000
has only substance units: false
is: SBO:0000252
initial amount: NaN

metaR EX sprm LPAREN e RPAREN
kinetic law: MODEL1310110045#
reactant: MODEL1310110045#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: PMID:10049700,PMID:10574970,PMID:11389679,PMID:11557028,PMID:11564694,PMID:12824232,PMID:12930836,PMID:14574404,PMID:16288981,PMID:911815 NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: EX_sprm(e)
type: Reaction

metaR r1291
product: MODEL1310110045#
is described by: ECO:0000000
kinetic law: MODEL1310110045#
is: SBO:0000185
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: 6.2.1.3 Confidence Level: 0 AUTHORS: PMID:8584017 NOTES:
reversible: true
name: Postulated transport reaction
reactant: MODEL1310110045#
fast: false

metaR r2387
reactant: MODEL1310110045#
modifier: MODEL1310110045#
is: SBO:0000185
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (215.1) or (U52111.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172 NOTES:
product: MODEL1310110045#
fast: false
reversible: false
kinetic law: MODEL1310110045#
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
type: Reaction

metaM ru5p D c
is: CHEBI:58121
is: SBO:0000247
has only substance units: false
constant: false
boundary condition: false
notes: FORMULA: C5H9O8P CHARGE: -2 INCHI: InChI=1S/C5H11O8P/c6-1-3(7)5(9)4(8)2-13-14(10,11)12/h4-6,8-9H,1-2H2,(H2,10,11,12)/p-2/t4-,5+/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00188
name: D-ribulose 5-phosphate(2-)
type: Species
is: HMDB00618
initial amount: NaN
initial concentration: 1.0

metaR MM8Ber
is version of: http://identifiers.org/ec-code/3.2.1.113
kinetic law: MODEL1310110045#
notes: GENE_ASSOCIATION: (11253.1) SUBSYSTEM: N-glycan synthesis EC Number: 3.2.1.113 Confidence Level: 0 AUTHORS: PMID:10409699,PMID:9592125 NOTES:NCD
type: Reaction
name: mannosyl-oligosaccharide 1,2-alpha-mannosidase, endoplasmic reticulum
reversible: false
is: SBO:0000176
is described by: ECO:0000000
reactant: MODEL1310110045#
fast: false
product: MODEL1310110045#
modifier: MODEL1310110045#

metaM pail hs c
constant: false
boundary condition: false
is: CHEBI:57880
initial amount: NaN
has only substance units: false
type: Species
notes: FORMULA: C9H16O9PFULLRCO2FULLR2CO2 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC02009 EHMN_ABBREVIATION: C01194
name: 1-phosphatidyl-1D-myo-inositol(1-)
is: SBO:0000247
initial concentration: 1.0

metaR LEUGLYPEPT1tc
kinetic law: MODEL1310110045#
product: MODEL1310110045#
reactant: MODEL1310110045#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of Leucylglycine by the apical PEPT1 amino acid transporters across the brush border cells of the enterocytes of the intestine and renal cells
type: Reaction

metaM ppi m
notes: FORMULA: HO7P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00023 EHMN_ABBREVIATION: C00013
initial concentration: 1.0
has only substance units: false
initial amount: NaN
boundary condition: false
type: Species
constant: false
is: CHEBI:33019
is: C00013
is: HMDB00250
name: Diphosphate
is: SBO:0000247

metaR r2386
notes: GENE_ASSOCIATION: (215.1) or (U52111.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172 NOTES:
product: MODEL1310110045#
reversible: false
modifier: MODEL1310110045#
is described by: ECO:0000000
reactant: MODEL1310110045#
fast: false
is: SBO:0000185
type: Reaction
kinetic law: MODEL1310110045#
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2

metaM C04849 e
has only substance units: false
is: CHEBI:57449
is: SBO:0000247
name: (5Z,9E,14Z)-(8xi,11R,12S)-11,12-epoxy-8-hydroxyicosa-5,9,14-trienoate
boundary condition: false
notes: FORMULA: C20H31O4 CHARGE: -1 INCHI: InChI=1S/C20H32O4/c1-2-3-4-5-6-10-13-18-19(24-18)16-15-17(21)12-9-7-8-11-14-20(22)23/h6-7,9-10,15-19,21H,2-5,8,11-14H2,1H3,(H,22,23)/p-1/b9-7-,10-6-,16-15+/t17?,18-,19+/m0/s1 EHMN_ABBREVIATION: C04849
type: Species
initial concentration: 1.0
constant: false
initial amount: NaN

metaR r1292
kinetic law: MODEL1310110045#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: 6.2.1.3 Confidence Level: 0 AUTHORS: PMID:8584017 NOTES:
is described by: ECO:0000000
reactant: MODEL1310110045#
type: Reaction
fast: false
product: MODEL1310110045#
is: SBO:0000185
reversible: true
name: Postulated transport reaction

metaM dgchol c
notes: FORMULA: C26H43NO5 CHARGE: 0 INCHI: InChI=1S/C26H43NO5/c1-15(4-7-22(30)27-14-23(31)32)18-5-6-19-24-20(9-11-26(18,19)3)25(2)10-8-17(28)12-16(25)13-21(24)29/h15-21,24,28-29H,4-14H2,1-3H3,(H,27,30)(H,31,32)/p-1/t15-,16+,17-,18-,19+,20+,21-,24+,25+,26-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01472
type: Species
initial concentration: 1.0
is: SBO:0000247
is: HMDB00637
has only substance units: false
is: CHEBI:36252
constant: false
boundary condition: false
initial amount: NaN
name: glycochenodeoxycholate

metaR r2389
modifier: MODEL1310110045#
is: SBO:0000185
reactant: MODEL1310110045#
is described by: ECO:0000000
fast: false
reversible: false
kinetic law: MODEL1310110045#
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
notes: GENE_ASSOCIATION: (215.1) or (U52111.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172 NOTES:
product: MODEL1310110045#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110045#_ddbccf34_f52a_4183_959b_9f0e2df58876
is: SBO:0000252
is: Q9H0P0
initial concentration: NaN
has only substance units: false
is encoded by: hsa:51251
type: Species
name: NT5C3
constant: false
boundary condition: true
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110045#_89d0358b_7780_4714_b31e_268ee4b15e39
name: PMM2
is: O15305
has only substance units: false
is encoded by: hsa:5373
is: SBO:0000252
initial concentration: NaN
boundary condition: true
constant: false
initial amount: NaN
type: Species

metaR FUMSO4tm
reactant: MODEL1310110045#
product: MODEL1310110045#
name: Fumarate:sulfate antiport, mitochondrial
notes: GENE_ASSOCIATION: (1468.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172,PMID:4441366 NOTES:MM
is: SBO:0000185
type: Reaction
fast: false
reversible: true
modifier: MODEL1310110045#
is described by: ECO:0000269
kinetic law: MODEL1310110045#

metaR EX gthrd LPAREN e RPAREN
kinetic law: MODEL1310110045#
reactant: MODEL1310110045#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Reduced glutathione exchange
type: Reaction

metaR r2388
is described by: ECO:0000000
is: SBO:0000185
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
reactant: MODEL1310110045#
reversible: false
kinetic law: MODEL1310110045#
type: Reaction
modifier: MODEL1310110045#
fast: false
notes: GENE_ASSOCIATION: (215.1) or (U52111.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172 NOTES:
product: MODEL1310110045#

metaR EX ocdcea LPAREN e RPAREN
kinetic law: MODEL1310110045#
reactant: MODEL1310110045#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: octadecenoate (n-C18:1) exchange
type: Reaction

metaR NACDe
kinetic law: MODEL1310110045#
product: MODEL1310110045#
reactant: MODEL1310110045#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: release of nicotinate at the basolateral surface
type: Reaction

metaR NACASPtm
name: N-acetyl-L-aspartate transport (mitochondria to cytosol)
reactant: MODEL1310110045#
type: Reaction
is: SBO:0000185
product: MODEL1310110045#
reversible: false
is described by: ECO:0000000
fast: false
kinetic law: MODEL1310110045#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: PMID:11279290 NOTES:MM

http://identifiers.org/biomodels.db/MODEL1310110045#_997d0860_dfd3_498f_8f08_6eb6348b22ce
has part: Q7GXZ4
is encoded by: hsa:7991
is encoded by: hsa:4714
has part: Q549M5
has part: Q9Y6M9
has part: B7Z792
is encoded by: hsa:4729
is encoded by: hsa:4701
has part: H7C5B8
is encoded by: hsa:4705
has part: Q6IBB5
has part: O95167
is encoded by: hsa:4540
is encoded by: hsa:4694
is encoded by: hsa:4719
is encoded by: hsa:4706
has part: P19404
is encoded by: hsa:4697
is encoded by: hsa:126328
is encoded by: hsa:4722
has part: O95168
is encoded by: hsa:4537
is encoded by: hsa:4698
is encoded by: hsa:4709
has part: P03897
is encoded by: hsa:4725
is encoded by: hsa:374291
is encoded by: hsa:4536
has only substance units: false
has part: O43677
has part: Q6IB80
has part: O43678
is encoded by: hsa:4712
has part: P56181
is encoded by: hsa:4716
type: Species
is encoded by: hsa:4702
has part: P03915
initial amount: NaN
has part: O75251
has part: Q16718
is encoded by: hsa:4717
has part: Q85KV6
is encoded by: hsa:4695
has part: O75438
is encoded by: hsa:4720
has part: Q6FG42
has part: O75489
is encoded by: hsa:4707
has part: Q13454
has part: O95299
is encoded by: hsa:4723
is encoded by: hsa:4538
initial concentration: NaN
has part: B1AM93
is encoded by: hsa:4710
has part: C9JT23
is encoded by: hsa:4726
has part: Q7GXY9
has part: Q9P0J0
is encoded by: hsa:4541
is encoded by: hsa:4713
has part: P56556
has part: O43674
has part: Q7GXZ1
has part: Q6IBA0
is encoded by: hsa:55967
is encoded by: hsa:4728
is encoded by: hsa:4700
has part: P17568
is encoded by: hsa:51079
is encoded by: hsa:4704
has part: O14561
has part: Q16795
is encoded by: hsa:4731
has part: Q6IBC4
is encoded by: hsa:4718
is: SBO:0000297
has part: O00483
is encoded by: hsa:4696

metaR PI45P3K
product: MODEL1310110045#
is version of: http://identifiers.org/ec-code/2.7.1.153
type: Reaction
is: SBO:0000176
name: phosphatidylinositol 4,5-bisphosphate 3-kinase
fast: false
reversible: false
is version of: http://identifiers.org/ec-code/2.7.11.1
is described by: ECO:0000000
reactant: MODEL1310110045#
modifier: MODEL1310110045#
kinetic law: MODEL1310110045#
notes: GENE_ASSOCIATION: (5291.1 and 5295.3) or (5293.1 and 8503.1) or (5296.1 and 5290.1) or (5293.1 and 5295.1) or (5293.1 and 5295.3) or (5291.1 and 5295.1) or (5296.1 and 5291.1) or (5295.2 and 5290.1) or (10870.1 and 5294.1) or (23533.1 and 5294.1) or (5295.2 and 5293.1) or (5290.1 and 5295.1) or (5290.1 and 8503.1) or (5290.1 and 5295.3) or (5291.1 and 8503.1) or (5293.1 and 5296.1) or (5295.2 and 5291.1) SUBSYSTEM: Inositol phosphate metabolism EC Number: 2.7.1.153 Confidence Level: 4 AUTHORS: PMID:12507995,PMID:15780590,PMID:2174051,PMID:7624799,PMID:7713498,PMID:8246984,PMID:9113989 NOTES:NCD

metaR r0502
reversible: true
is version of: http://identifiers.org/ec-code/2.7.1.113
kinetic law: MODEL1310110045#
product: MODEL1310110045#
is described by: ECO:0000000
reactant: MODEL1310110045#
is: SBO:0000176
fast: false
name: xanthine:NAD+ oxidoreductase Purine metabolism EC:1.17.1.4
type: Reaction
modifier: MODEL1310110045#
notes: GENE_ASSOCIATION: (1716.1) or (NM_001929.1) SUBSYSTEM: Purine catabolism EC Number: 1.17.1.4 Confidence Level: 0 AUTHORS: PMID:11246119,PMID:12632927 NOTES:

metaM leuktrC4 c
initial concentration: 1.0
boundary condition: false
name: leukotriene C4(2-)
initial amount: NaN
notes: FORMULA: C30H45N3O9S CHARGE: -2 INCHI: InChI=1S/C30H47N3O9S/c1-2-3-4-5-6-7-8-9-10-11-12-13-16-25(24(34)15-14-17-27(36)37)43-21-23(29(40)32-20-28(38)39)33-26(35)19-18-22(31)30(41)42/h6-7,9-13,16,22-25,34H,2-5,8,14-15,17-21,31H2,1H3,(H,32,40)(H,33,35)(H,36,37)(H,38,39)(H,41,42)/p-2/b7-6-,10-9-,12-11+,16-13+/t22-,23-,24-,25+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00898 EHMN_ABBREVIATION: C02166
constant: false
is: SBO:0000247
has only substance units: false
type: Species
is: HMDB01198
is: CHEBI:57973

metaM 2mbcoa m
is: HMDB01041
is: SBO:0000247
is: CHEBI:57336
has only substance units: false
constant: false
initial amount: NaN
type: Species
boundary condition: false
notes: FORMULA: C26H40N7O17P3S CHARGE: -4 INCHI: InChI=1S/C26H44N7O17P3S/c1-5-14(2)25(38)54-9-8-28-16(34)6-7-29-23(37)20(36)26(3,4)11-47-53(44,45)50-52(42,43)46-10-15-19(49-51(39,40)41)18(35)24(48-15)33-13-32-17-21(27)30-12-31-22(17)33/h12-15,18-20,24,35-36H,5-11H2,1-4H3,(H,28,34)(H,29,37)(H,42,43)(H,44,45)(H2,27,30,31)(H2,39,40,41)/p-4/t14?,15-,18-,19-,20+,24-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00632 EHMN_ABBREVIATION: C01033
initial concentration: 1.0
name: 2-methylbutanoyl-CoA(4-)

metaM ha pre1 e
type: Species
is: CHEBI:16126
notes: FORMULA: C14H20NO11 CHARGE: -1 INCHI: InChI=1S/C14H21NO11/c1-4(17)15-8-11(10(20)7(3-16)24-13(8)23)26-14-9(19)5(18)2-6(25-14)12(21)22/h2,5,7-11,13-14,16,18-20,23H,3H2,1H3,(H,15,17)(H,21,22)/t5-,7+,8+,9+,10+,11+,13+,14-/m0/s1
is: SBO:0000247
initial concentration: 1.0
name: hyaluronan biosynthesis, precursor 1
boundary condition: false
constant: false
has only substance units: false
initial amount: NaN

metaM Sfglutth c
has only substance units: false
notes: FORMULA: C11H16N3O7S CHARGE: -1 INCHI: InChI=1S/C11H17N3O7S/c12-6(11(20)21)1-2-8(16)14-7(4-22-5-15)10(19)13-3-9(17)18/h5-7H,1-4,12H2,(H,13,19)(H,14,16)(H,17,18)(H,20,21)/p-1/t6-,7-/m0/s1 EHMN_ABBREVIATION: C01031
initial amount: NaN
boundary condition: false
constant: false
is: HMDB01550
is: SBO:0000247
type: Species
name: S-formylglutathionate(1-)
initial concentration: 1.0
is: CHEBI:57688

http://identifiers.org/biomodels.db/MODEL1310110045#_abaca672_6a47_4e28_aa01_70db02938b39
type: Species
boundary condition: true
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:3038
is: O00219
name: HAS3
constant: false
initial amount: NaN
has only substance units: false

metaR THMPPtm
kinetic law: MODEL1310110045#
name: Thiamine diphosphate transport in via anion antiport, mitochondria
reversible: false
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:12014993 NOTES:IT
is described by: ECO:0000000
product: MODEL1310110045#
is: SBO:0000185
reactant: MODEL1310110045#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110045#_697bf532_0682_403a_abd0_c113ef0ad493
initial concentration: NaN
is: SBO:0000252
initial amount: NaN
has only substance units: false
is: P47895
is encoded by: hsa:220
name: ALDH1A3
type: Species
boundary condition: true
constant: false

metaM ppi r
is: C00013
initial concentration: 1.0
is: CHEBI:33019
constant: false
name: Diphosphate
type: Species
boundary condition: false
is: HMDB00250
has only substance units: false
notes: FORMULA: HO7P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00023 EHMN_ABBREVIATION: C00013
initial amount: NaN
is: SBO:0000247

metaM didp n
notes: FORMULA: C10H11N4O10P2 CHARGE: -3 INCHI: InChI=1S/C10H14N4O10P2/c15-5-1-7(14-4-13-8-9(14)11-3-12-10(8)16)23-6(5)2-22-26(20,21)24-25(17,18)19/h3-7,15H,1-2H2,(H,20,21)(H,11,12,16)(H2,17,18,19)/t5-,6+,7+/m0/s1 EHMN_ABBREVIATION: C01344
is: HMDB03536
boundary condition: false
type: Species
initial amount: NaN
is: SBO:0000247
is: CHEBI:28823
name: dIDP
constant: false
initial concentration: 1.0
has only substance units: false

metaR BDHm
reversible: true
kinetic law: MODEL1310110045#
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/1.1.1.30
type: Reaction
modifier: MODEL1310110045#
name: (R)-3-Hydroxybutanoate:NAD+ oxidoreductase
fast: false
reactant: MODEL1310110045#
product: MODEL1310110045#
notes: GENE_ASSOCIATION: (622.2) or (622.3) or (622.1) SUBSYSTEM: Butanoate metabolism EC Number: 1.1.1.30 Confidence Level: 4 AUTHORS: PMID:1639787,PMID:8679568 NOTES:IT
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110045#_6f871f9a_2e19_4a10_8cdb_54edfe6e0799
initial amount: NaN
is: SBO:0000252
is encoded by: hsa:89874
initial concentration: NaN
boundary condition: true
name: SLC25A21
is: G3V4L5
has only substance units: false
constant: false
type: Species

metaM q10h2 m
is: SBO:0000247
boundary condition: false
initial amount: NaN
is: http://identifiers.org/pubchem.compound/6504740
notes: FORMULA: C59H92O4 CHARGE: 0 INCHI: InChI=1/C59H92O4/c1-44(2)24-15-25-45(3)26-16-27-46(4)28-17-29-47(5)30-18-31-48(6)32-19-33-49(7)34-20-35-50(8)36-21-37-51(9)38-22-39-52(10)40-23-41-53(11)42-43-55-54(12)56(60)58(62-13)59(63-14)57(55)61/h24,26,28,30,32,34,36,38,40,42,60-61H,15-23,25,27,29,31,33,35,37,39,41,43H2,1-14H3/b45-26+,46-28+,47-30+,48-32+,49-34+,50-36+,51-38+,52-40+,53-42+ HEPATONET_1.0_ABBREVIATION: HC00324
has only substance units: false
constant: false
is: HMDB13111
type: Species
name: Ubiquinol-10
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110045#_60fdecd6_da82_4269_8526_60f6cdc396d0
is: Q9NRX3
boundary condition: true
is: SBO:0000252
name: NDUFA4L2
initial amount: NaN
type: Species
constant: false
initial concentration: NaN
is encoded by: hsa:56901
has only substance units: false

metaR r0504
is described by: ECO:0000000
reactant: MODEL1310110045#
is: SBO:0000176
type: Reaction
kinetic law: MODEL1310110045#
modifier: MODEL1310110045#
name: Xanthine:oxygen oxidoreductase Purine metabolism EC:1.17.3.2
reversible: true
fast: false
product: MODEL1310110045#
notes: GENE_ASSOCIATION: (AI090874.1) or (AL048840.1) or (BG035985.1) or (3157.1) or (3158.1) SUBSYSTEM: Purine catabolism EC Number: 1.17.3.2 Confidence Level: 0 AUTHORS: PMID:16087479,PMID:1643670,PMID:16756494,PMID:18600557,PMID:8343533 NOTES:
is version of: http://identifiers.org/ec-code/2.3.3.10

metaR RETI1
fast: false
kinetic law: MODEL1310110045#
is: SBO:0000176
type: Reaction
product: MODEL1310110045#
reversible: true
reactant: MODEL1310110045#
notes: GENE_ASSOCIATION: SUBSYSTEM: Vitamin A metabolism EC Number: 5.2.1.7 Confidence Level: 2 AUTHORS: PMID:1503811 NOTES:IT
is described by: ECO:0000000
name: retinol isomerase (11-cis)

http://identifiers.org/biomodels.db/MODEL1310110045#_47f9ce1d_c4b6_44df_87d8_20c90e7ab5fa
has only substance units: false
is: Q8TF71
initial concentration: NaN
is: SBO:0000252
boundary condition: true
initial amount: NaN
name: SLC16A10
constant: false
is encoded by: hsa:117247
type: Species

http://identifiers.org/biomodels.db/MODEL1310110045#_71e06074_cd0d_42e7_8559_c1fd36fcfa72
initial amount: NaN
type: Species
initial concentration: NaN
has part: P51553
is encoded by: hsa:3421
name: IDH3A:IDH3B:IDH3G
has only substance units: false
boundary condition: true
constant: false
has part: O43837
is encoded by: hsa:3420
is: SBO:0000297

http://identifiers.org/biomodels.db/MODEL1310110045#_9b27d35f_c61c_4638_8865_636486a81a2b
name: SLC29A1
is encoded by: hsa:2030
boundary condition: true
is: SBO:0000252
initial amount: NaN
type: Species
constant: false
has only substance units: false
initial concentration: NaN
is: Q99808

http://identifiers.org/biomodels.db/MODEL1310110045#_8eedc31c_abd9_4f7d_88d2_32d2d2ca7b59
is: SBO:0000252
is encoded by: hsa:8879
name: SGPL1
type: Species
boundary condition: true
initial concentration: NaN
is: O95470
has only substance units: false
initial amount: NaN
constant: false

http://identifiers.org/biomodels.db/MODEL1310110045#_22c7fc0b_bf84_494e_8a6c_3dfe3434947b
is encoded by: hsa:4697
boundary condition: true
name: NDUFA4
initial concentration: NaN
type: Species
is: O00483
constant: false
has only substance units: false
is: SBO:0000252
initial amount: NaN

metaM leuktrC4 e
is: SBO:0000247
initial concentration: 1.0
is: HMDB01198
type: Species
is: CHEBI:57973
initial amount: NaN
has only substance units: false
notes: FORMULA: C30H45N3O9S CHARGE: -2 INCHI: InChI=1S/C30H47N3O9S/c1-2-3-4-5-6-7-8-9-10-11-12-13-16-25(24(34)15-14-17-27(36)37)43-21-23(29(40)32-20-28(38)39)33-26(35)19-18-22(31)30(41)42/h6-7,9-13,16,22-25,34H,2-5,8,14-15,17-21,31H2,1H3,(H,32,40)(H,33,35)(H,36,37)(H,38,39)(H,41,42)/p-2/b7-6-,10-9-,12-11+,16-13+/t22-,23-,24-,25+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00898 EHMN_ABBREVIATION: C02166
boundary condition: false
name: leukotriene C4(2-)
constant: false

metaM tymsf c
boundary condition: false
constant: false
notes: FORMULA: C8H11NO4S CHARGE: 0 INCHI: InChI=1/C8H11NO4S/c9-6-5-7-1-3-8(4-2-7)13-14(10,11)12/h1-4H,5-6,9H2,(H,10,11,12)
is: SBO:0000247
name: Tyramine O-sulfate
initial amount: NaN
is: HMDB06409
type: Species
has only substance units: false
initial concentration: 1.0

metaR NACHEXA15ly
is version of: http://identifiers.org/ec-code/3.2.1.52
is: SBO:0000176
product: MODEL1310110045#
type: Reaction
fast: false
notes: GENE_ASSOCIATION: (3073.1) or (3073.1 and 3074.1) SUBSYSTEM: Keratan sulfate degradation EC Number: Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12706724,PMID:8993162 NOTES:Note that this reaction is specific to beta-N-acetylhexosaminidase A and cannot be catalyzed by beta-N-acetylhexosaminidase B (or presumably beta-N-acetylhexosaminidase S). This is also a lumped reaction, representing the cleavage of GalNAc4S or GalNAc6S and N-acetylgalactosamine 4-sulfatase or 6-sulfatase. NCD
reversible: false
is described by: ECO:0000000
name: beta-N-acetylhexosaminidase A, lysosomal
reactant: MODEL1310110045#
kinetic law: MODEL1310110045#
modifier: MODEL1310110045#

http://identifiers.org/biomodels.db/MODEL1310110045#_f77cbbf7_ee91_4156_9620_d97042370c9d
initial concentration: NaN
constant: false
initial amount: NaN
type: Species
boundary condition: true
name: GANC
is: Q8TET4
is encoded by: hsa:2595
has only substance units: false
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110045#_6a4e65d2_c445_4322_9474_a1cedd7554ca
boundary condition: true
initial amount: NaN
name: _PRO1933_1_m
type: Species
is encoded by: hsa:PRO1933
constant: false
has only substance units: false
initial concentration: NaN
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110045#_b7ec4300_0804_4432_bc86_88ad14ad3622
is encoded by: hsa:129642
name: MBOAT2
type: Species
boundary condition: true
initial concentration: NaN
is: SBO:0000252
has only substance units: false
initial amount: NaN
constant: false
is: Q6ZWT7

http://identifiers.org/biomodels.db/MODEL1310110045#_918a9bd3_d97d_4af1_9433_09c9d5d168fb
is: SBO:0000252
boundary condition: true
type: Species
name: SLC4A1
has only substance units: false
initial concentration: NaN
is: P02730
initial amount: NaN
constant: false
is encoded by: hsa:6521

metaR RE1526M
fast: false
modifier: MODEL1310110045#
reversible: true
notes: GENE_ASSOCIATION: (3295.1) or (1962.1) or (3033.1) or (3028.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.1.1.35 Confidence Level: 0 AUTHORS: PMID:11451959 NOTES:
reactant: MODEL1310110045#
is described by: ECO:0000000
name: RE1526
kinetic law: MODEL1310110045#
is version of: http://identifiers.org/ec-code/4.2.1.107
is version of: http://identifiers.org/ec-code/1.1.1.35
is: SBO:0000176
product: MODEL1310110045#
type: Reaction

metaR O2t
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 1 AUTHORS: NOTES:tv renamed from O2TP to O2t to avoid confusion with transport reaction from cytosol to peroxisome NCD
reactant: MODEL1310110045#
is: SBO:0000185
fast: false
product: MODEL1310110045#
name: o2 transport (diffusion)
type: Reaction
kinetic law: MODEL1310110045#
is described by: ECO:0000000
reversible: true

metaM orn e
constant: false
boundary condition: false
is: C01602
notes: FORMULA: C5H13N2O2 CHARGE: 1
initial amount: NaN
initial concentration: 1.0
name: Ornithine
type: Species
has only substance units: false
is: HMDB00214
is: SBO:0000247
is: CHEBI:0

http://identifiers.org/biomodels.db/MODEL1310110045#_6db752e7_6d37_4b52_8055_dbbb5f6dfd12
boundary condition: true
constant: false
is: F8WDN9
name: PPA2
initial amount: NaN
is encoded by: hsa:27068
type: Species
initial concentration: NaN
has only substance units: false
is: SBO:0000252

metaR ACGAMK
reversible: false
is: SBO:0000176
is described by: ECO:0000269
reactant: MODEL1310110045#
type: Reaction
product: MODEL1310110045#
modifier: MODEL1310110045#
fast: false
name: N-acetylglucosamine kinase
is version of: http://identifiers.org/ec-code/2.7.1.59
notes: GENE_ASSOCIATION: (55577.1) SUBSYSTEM: Aminosugar metabolism EC Number: 2.7.1.59 Confidence Level: 4 AUTHORS: PMID:10824116 NOTES:
kinetic law: MODEL1310110045#

http://identifiers.org/biomodels.db/MODEL1310110045#_4d5029ac_d46b_4dd2_924f_62300142961a
is: SBO:0000252
initial concentration: NaN
type: Species
boundary condition: true
has only substance units: false
name: GGT2
is encoded by: hsa:728441
initial amount: NaN
constant: false

metaR PCHOLPr hs
modifier: MODEL1310110045#
kinetic law: MODEL1310110045#
name: choline phosphatase
notes: GENE_ASSOCIATION: (5337.1) SUBSYSTEM: Glycerophospholipid metabolism EC Number: 3.1.4.4 Confidence Level: 4 AUTHORS: PMID:11481335,PMID:8530346 NOTES:NJ
fast: false
is: SBO:0000176
reversible: false
type: Reaction
is version of: http://identifiers.org/ec-code/3.1.4.4
reactant: MODEL1310110045#
is described by: ECO:0000269
product: MODEL1310110045#

metaM hco3 c
is: HMDB00595
type: Species
name: Bicarbonate
has only substance units: false
notes: FORMULA: CHO3 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00253 EHMN_ABBREVIATION: C00288
is: CHEBI:17544
is: C00288
is: SBO:0000247
constant: false
initial concentration: 1.0
boundary condition: false
initial amount: NaN

metaR FAOXC123m
kinetic law: MODEL1310110045#
product: MODEL1310110045#
reactant: MODEL1310110045#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: isomerization(C12:3)m
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110045#_b2783bc3_9f5d_40aa_86c9_cee1b74362f7
is: SBO:0000252
initial amount: NaN
name: _AI620219_1_c
initial concentration: NaN
is encoded by: hsa:AI620219
has only substance units: false
boundary condition: true
type: Species
constant: false

http://identifiers.org/biomodels.db/MODEL1310110045#_d730f705_4afd_416e_ab2e_fc1baa93d162
is encoded by: hsa:8659
has only substance units: false
is: SBO:0000252
initial concentration: NaN
initial amount: NaN
constant: false
boundary condition: true
type: Species
name: ALDH4A1

metaM lnlncgcoa m
name: gamma-linolenoyl-CoA(4-)
is: HMDB06368
is: CHEBI:57363
constant: false
initial amount: NaN
boundary condition: false
has only substance units: false
notes: FORMULA: C39H60N7O17P3S CHARGE: -4 INCHI: InChI=1S/C39H64N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-30(48)67-23-22-41-29(47)20-21-42-37(51)34(50)39(2,3)25-60-66(57,58)63-65(55,56)59-24-28-33(62-64(52,53)54)32(49)38(61-28)46-27-45-31-35(40)43-26-44-36(31)46/h8-9,11-12,14-15,26-28,32-34,38,49-50H,4-7,10,13,16-25H2,1-3H3,(H,41,47)(H,42,51)(H,55,56)(H,57,58)(H2,40,43,44)(H2,52,53,54)/p-4/b9-8-,12-11-,15-14-/t28-,32-,33-,34+,38-/m1/s1 EHMN_ABBREVIATION: C03035
is: SBO:0000247
type: Species
initial concentration: 1.0

metaM ppcoa x
name: Propanoyl-CoA
is: SBO:0000247
constant: false
is: CHEBI:57392
initial concentration: 1.0
notes: FORMULA: C24H36N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00101 EHMN_ABBREVIATION: C00100
is: C00100
is: HMDB01275
has only substance units: false
initial amount: NaN
type: Species
boundary condition: false

metaM tymsf e
is: SBO:0000247
boundary condition: false
notes: FORMULA: C8H11NO4S CHARGE: 0 INCHI: InChI=1/C8H11NO4S/c9-6-5-7-1-3-8(4-2-7)13-14(10,11)12/h1-4H,5-6,9H2,(H,10,11,12)
initial amount: NaN
is: HMDB06409
name: Tyramine O-sulfate
type: Species
constant: false
has only substance units: false
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110045#_9098cc3e_6a90_4133_aabd_254676e5de98
name: FDFT1
constant: false
boundary condition: true
initial concentration: NaN
is: P37268
is: SBO:0000252
type: Species
is encoded by: hsa:2222
initial amount: NaN
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110045#_9f7edbae_2c6a_4d65_a696_a529b6c426b7
is: Q9BV79
has only substance units: false
boundary condition: true
is encoded by: hsa:51102
is: SBO:0000252
name: MECR
initial concentration: NaN
initial amount: NaN
constant: false
type: Species

metaR NACHEXA12ly
reversible: false
name: beta-N-acetylhexosaminidase A, lysosomal
is: SBO:0000176
fast: false
is described by: ECO:0000000
modifier: MODEL1310110045#
product: MODEL1310110045#
notes: GENE_ASSOCIATION: (3073.1) or (3073.1 and 3074.1) SUBSYSTEM: Keratan sulfate degradation EC Number: Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12706724,PMID:8993162 NOTES:Note that this reaction is specific to beta-N-acetylhexosaminidase A and cannot be catalyzed by beta-N-acetylhexosaminidase B (or presumably beta-N-acetylhexosaminidase S). This is also a lumped reaction, representing the cleavage of GalNAc4S or GalNAc6S and N-acetylgalactosamine 4-sulfatase or 6-sulfatase. NCD
reactant: MODEL1310110045#
type: Reaction
kinetic law: MODEL1310110045#
is version of: http://identifiers.org/ec-code/3.2.1.52

metaR TAURCHAe
reactant: MODEL1310110045#
reversible: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID: 14992263 NOTES:taurine is an osmolyte that aids in osmoregulation. Reactive oxygen species (ROS) and eicosanoids activate tyrosine-kinase cascade, resulting in activation of volume sensitive taurine channel. Further ROS causes membrane permeabilization that results in taruine loss.
product: MODEL1310110045#
is: SBO:0000185
is described by: ECO:0000134
type: Reaction
name: exit of taurine from the enterocytes
fast: false
kinetic law: MODEL1310110045#

metaR r0614
name: N-[(R)-4-Phosphopantothenoyl]-L-cysteine carboxy-lyase Pantothenate and CoA biosynthesis EC:4.1.1.36
reactant: MODEL1310110045#
notes: GENE_ASSOCIATION: SUBSYSTEM: CoA synthesis EC Number: 4.1.1.36 Confidence Level: 0 AUTHORS: PMID:11923312,PMID:13630913,PMID:15893380,PMID:4459135,PMID:6061681 NOTES:
kinetic law: MODEL1310110045#
fast: false
reversible: true
product: MODEL1310110045#
is described by: ECO:0000000
is: SBO:0000176
type: Reaction

metaR GK1
fast: false
is: SBO:0000176
product: MODEL1310110045#
reactant: MODEL1310110045#
is described by: ECO:0000269
name: guanylate kinase (GMP:ATP)
kinetic law: MODEL1310110045#
reversible: true
modifier: MODEL1310110045#
type: Reaction
is version of: http://identifiers.org/ec-code/2.7.4.8
notes: GENE_ASSOCIATION: (2987.1) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: NOTES:

http://identifiers.org/biomodels.db/MODEL1310110045#_37b86ae9_a190_4982_a819_30f14429af7d
is: Q9NZ20
has only substance units: false
initial concentration: NaN
type: Species
is: SBO:0000252
constant: false
is encoded by: hsa:50487
boundary condition: true
name: PLA2G3
initial amount: NaN

metaM amp r
is: C00020
is: CHEBI:456215
type: Species
has only substance units: false
name: AMP
constant: false
boundary condition: false
initial amount: NaN
notes: FORMULA: C10H12N5O7P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00030 EHMN_ABBREVIATION: C00020
initial concentration: 1.0
is: SBO:0000247
is: HMDB00045

http://identifiers.org/biomodels.db/MODEL1310110045#_c057733b_b32e_4bc2_abbc_f46d55b3d42f
has only substance units: false
boundary condition: true
initial concentration: NaN
is: SBO:0000252
is: P17568
name: NDUFB7
is encoded by: hsa:4713
constant: false
type: Species
initial amount: NaN

metaM orn c
notes: FORMULA: C5H13N2O2 CHARGE: 1
boundary condition: false
constant: false
is: C01602
initial concentration: 1.0
name: Ornithine
initial amount: NaN
has only substance units: false
type: Species
is: HMDB00214
is: CHEBI:0
is: SBO:0000247

metaM chsterol r
notes: FORMULA: C27H46O CHARGE: 0 INCHI: InChI=1S/C27H46O/c1-18(2)7-6-8-19(3)23-11-12-24-22-10-9-20-17-21(28)13-15-26(20,4)25(22)14-16-27(23,24)5/h9,18-19,21-25,28H,6-8,10-17H2,1-5H3/t19-,21+,22+,23-,24+,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00178 EHMN_ABBREVIATION: C00187
has only substance units: false
is: CHEBI:16113
constant: false
is: SBO:0000247
type: Species
is: HMDB00067
boundary condition: false
initial concentration: 1.0
initial amount: NaN
name: cholesterol

http://identifiers.org/biomodels.db/MODEL1310110045#_ec47bcb6_7598_4a21_a019_77d97fe433e3
initial amount: NaN
is: Q6ZWP6
has only substance units: false
constant: false
boundary condition: true
is encoded by: hsa:27034
initial concentration: NaN
is: SBO:0000252
type: Species
name: ACAD8

http://identifiers.org/biomodels.db/MODEL1310110045#_b764be31_43aa_4648_8fae_7e7e7e82f559
is: SBO:0000252
is encoded by: hsa:5313
boundary condition: true
type: Species
has only substance units: false
is: P30613
name: PKLR
initial amount: NaN
constant: false
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110045#_9b6b1357_d7e8_4f70_a363_74413547f3f0
is encoded by: hsa:1718
constant: false
is: Q15392
initial concentration: NaN
has only substance units: false
initial amount: NaN
type: Species
boundary condition: true
name: DHCR24
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110045#_2c758b19_9683_43ff_9a19_5977050d1106
initial amount: NaN
is encoded by: hsa:10599
is: SBO:0000252
constant: false
is: Q9Y6L6
has only substance units: false
initial concentration: NaN
name: SLCO1B1
boundary condition: true
type: Species

metaM ppi e
is: CHEBI:33019
name: Diphosphate
boundary condition: false
is: C00013
is: HMDB00250
initial concentration: 1.0
has only substance units: false
is: SBO:0000247
constant: false
initial amount: NaN
type: Species
notes: FORMULA: HO7P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00023 EHMN_ABBREVIATION: C00013

metaR RE3565C
is: SBO:0000176
name: RE3565
reversible: true
fast: false
type: Reaction
product: MODEL1310110045#
reactant: MODEL1310110045#
notes: GENE_ASSOCIATION: SUBSYSTEM: Eicosanoid metabolism EC Number: 5.3.3.9 Confidence Level: 0 AUTHORS: PMID:234423 NOTES:
is described by: ECO:0000000
kinetic law: MODEL1310110045#

http://identifiers.org/biomodels.db/MODEL1310110045#_3e297273_1123_4fd6_84ad_b59cca486b8d
constant: false
is: SBO:0000297
name: IDH3A:IDH3B:IDH3G
has only substance units: false
type: Species
initial amount: NaN
is encoded by: hsa:3420
initial concentration: NaN
boundary condition: true

metaM m1mpdol L c
initial amount: NaN
is: CHEBI:28067
initial concentration: 1.0
constant: false
name: alpha-D-mannosyl-beta-D-mannosyl-diacylchitobiosyldiphosphodolichol, human liver homolog
boundary condition: false
type: Species
notes: FORMULA: C1360H2228N20O270P20 CHARGE: -20 INCHI: InChI=1S/C53H92N2O27P2/c1-27(2)13-9-14-28(3)15-10-16-29(4)17-11-18-30(5)19-12-20-31(6)21-22-73-83(69,70)82-84(71,72)81-51-39(55-33(8)61)43(65)47(37(26-59)77-51)78-50-38(54-32(7)60)42(64)48(36(25-58)76-50)79-53-46(68)49(41(63)35(24-57)75-53)80-52-45(67)44(66)40(62)34(23-56)74-52/h13,15,17,19,31,34-53,56-59,62-68H,9-12,14,16,18,20-26H2,1-8H3,(H,54,60)(H,55,61)(H,69,70)(H,71,72)/b28-15+,29-17+,30-19+/t31?,34-,35-,36-,37-,38-,39-,40-,41-,42-,43-,44+,45+,46+,47-,48-,49+,50+,51-,52-,53+/m1/s1
is: SBO:0000247
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110045#_ce84323b_f5b2_4cd1_b92b_92d079933a43
constant: false
initial concentration: NaN
is encoded by: hsa:4725
is: SBO:0000252
name: NDUFS5
has only substance units: false
initial amount: NaN
is: Q6IBA0
type: Species
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110045#_daceb794_5a99_4103_b324_7f79069d75ec
is: P21953
is: SBO:0000252
constant: false
type: Species
name: BCKDHB
boundary condition: true
is encoded by: hsa:594
has only substance units: false
initial concentration: NaN
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110045#_38d08b56_9b1a_446e_9011_d3a48624aa9b
initial amount: NaN
is: P55084
name: HADHB
boundary condition: true
constant: false
has only substance units: false
is: SBO:0000252
initial concentration: NaN
is encoded by: hsa:3032
type: Species

http://identifiers.org/biomodels.db/MODEL1310110045#_54bb5a8a_526f_4a89_92a0_1339891d3649
is encoded by: hsa:27232
has only substance units: false
is: SBO:0000252
constant: false
initial concentration: NaN
is: Q14749
boundary condition: true
name: GNMT
initial amount: NaN
type: Species

metaR OCOAT1m
type: Reaction
product: MODEL1310110045#
fast: false
kinetic law: MODEL1310110045#
reversible: true
modifier: MODEL1310110045#
notes: GENE_ASSOCIATION: (5019.1) or (64064.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 2.8.3.5 Confidence Level: 4 AUTHORS: PMID:10964512,PMID:11756565 NOTES:TDV
is version of: http://identifiers.org/ec-code/2.8.3.5
is described by: ECO:0000269
reactant: MODEL1310110045#
name: 3-oxoacid CoA-transferase
is: SBO:0000176

metaR GALASE4ly
fast: false
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/3.2.1.23
is: SBO:0000176
product: MODEL1310110045#
kinetic law: MODEL1310110045#
reactant: MODEL1310110045#
is version of: http://identifiers.org/ec-code/3.4.16.5
is version of: http://identifiers.org/ec-code/3.1.6.4
modifier: MODEL1310110045#
reversible: false
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) or (5476.1) and (2720.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.23 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD
type: Reaction
name: beta-galactosidase, lysosomal
is version of: http://identifiers.org/ec-code/3.2.1.18

metaM HC01401 m
name: (S)-3-Hydroxydodecanoyl-CoA
notes: FORMULA: C33H54N7O18P3S CHARGE: -4 INCHI: InChI=1S/C33H58N7O18P3S/c1-4-5-6-7-8-9-10-11-21(41)16-24(43)62-15-14-35-23(42)12-13-36-31(46)28(45)33(2,3)18-55-61(52,53)58-60(50,51)54-17-22-27(57-59(47,48)49)26(44)32(56-22)40-20-39-25-29(34)37-19-38-30(25)40/h19-22,26-28,32,41,44-45H,4-18H2,1-3H3,(H,35,42)(H,36,46)(H,50,51)(H,52,53)(H2,34,37,38)(H2,47,48,49)/t21-,22+,26+,27+,28-,32+/m0/s1 EHMN_ABBREVIATION: C05262
is: SBO:0000247
boundary condition: false
initial concentration: 1.0
is: CHEBI:27668
initial amount: NaN
type: Species
has only substance units: false
constant: false

metaR BACCLm
fast: false
type: Reaction
is described by: ECO:0000254
modifier: MODEL1310110045#
kinetic law: MODEL1310110045#
name: biotin-[acetyl-CoA-carboxylase] ligase, mitochondrial
product: MODEL1310110045#
is version of: http://identifiers.org/ec-code/6.3.4.10
reversible: false
is: SBO:0000176
notes: GENE_ASSOCIATION: (3141.1) SUBSYSTEM: Biotin metabolism EC Number: 6.3.4.15 Confidence Level: 2 AUTHORS: PMID:12459313,PMID:7842009 NOTES:IT
reactant: MODEL1310110045#

metaR FACOAL2252
reversible: true
modifier: MODEL1310110045#
is version of: http://identifiers.org/ec-code/6.2.1.3
reactant: MODEL1310110045#
product: MODEL1310110045#
is described by: ECO:0000269
is: SBO:0000176
name: fatty-acid--CoA ligase
notes: GENE_ASSOCIATION: (2180.1) SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 4 AUTHORS: PMID:15292367 NOTES:NJ
kinetic law: MODEL1310110045#
type: Reaction
fast: false

metaM didp c
is: SBO:0000247
initial concentration: 1.0
type: Species
boundary condition: false
initial amount: NaN
has only substance units: false
notes: FORMULA: C10H11N4O10P2 CHARGE: -3 INCHI: InChI=1S/C10H14N4O10P2/c15-5-1-7(14-4-13-8-9(14)11-3-12-10(8)16)23-6(5)2-22-26(20,21)24-25(17,18)19/h3-7,15H,1-2H2,(H,20,21)(H,11,12,16)(H2,17,18,19)/t5-,6+,7+/m0/s1 EHMN_ABBREVIATION: C01344
is: CHEBI:28823
constant: false
name: dIDP
is: HMDB03536

metaM ksi pre35 g
is: SBO:0000247
boundary condition: false
name: keratan sulfate I biosynthesis, precursor 35
is: CHEBI:28067
constant: false
initial amount: NaN
has only substance units: false
notes: FORMULA: C241H384N17O205S11X CHARGE: -12
type: Species
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110045#_d10208f9_4e35_4787_8895_dbf3af83f470
constant: false
boundary condition: true
name: _AA526438_1_m
initial amount: NaN
type: Species
initial concentration: NaN
has only substance units: false
is: SBO:0000252
is encoded by: hsa:AA526438

http://identifiers.org/biomodels.db/MODEL1310110045#_928dd377_31a5_45f3_8fa4_63059bb0cb4b
name: RRM1
initial concentration: NaN
is encoded by: hsa:6240
boundary condition: true
initial amount: NaN
has only substance units: false
is: SBO:0000252
is: P23921
constant: false
type: Species

metaR GTHOm
is: SBO:0000176
is described by: ECO:0000254
reactant: MODEL1310110045#
type: Reaction
is version of: http://identifiers.org/ec-code/1.8.1.7
name: glutathione oxidoreductase
modifier: MODEL1310110045#
fast: false
kinetic law: MODEL1310110045#
reversible: false
notes: GENE_ASSOCIATION: (2936.1) SUBSYSTEM: Glutamate metabolism EC Number: 1.8.1.7 Confidence Level: 2 AUTHORS: PMID:10708558,PMID:15149466 NOTES:NCD, TV This EC (1.6.4.2) is obsolete. The new EC is 1.8.1.7. http://www.genome.ad.jp/dbget-bin/www_bget?ec:1.6.4.2
product: MODEL1310110045#

metaR DGCHOLte
reactant: MODEL1310110045#
type: Reaction
kinetic law: MODEL1310110045#
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 1 AUTHORS: NOTES:unknown mechanism, however bile acids need to be secreted out of the cell NJ
fast: false
name: bile acid intracellular transport
is: SBO:0000185
is described by: ECO:0000000
product: MODEL1310110045#

http://identifiers.org/biomodels.db/MODEL1310110045#_bb77aef4_c23d_404e_88dd_4ca3c98a8aac
constant: false
initial concentration: NaN
is: O75489
type: Species
boundary condition: true
name: NDUFS3
is: SBO:0000252
initial amount: NaN
has only substance units: false
is encoded by: hsa:4722

metaR EX pglyc hs LPAREN e RPAREN
kinetic law: MODEL1310110045#
reactant: MODEL1310110045#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: phosphatidylglycerol (homo sapiens) exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110045#_6b089647_7732_4d06_a6f1_d835c50aa6f9
boundary condition: true
type: Species
is: SBO:0000252
initial concentration: NaN
is: O95299
has only substance units: false
initial amount: NaN
name: NDUFA10
constant: false
is encoded by: hsa:4705

metaM dutp n
initial amount: NaN
is: CHEBI:17625
type: Species
initial concentration: 1.0
notes: FORMULA: C9H11N2O14P3 CHARGE: -4 INCHI: InChI=1S/C9H15N2O14P3/c12-5-3-8(11-2-1-7(13)10-9(11)14)23-6(5)4-22-27(18,19)25-28(20,21)24-26(15,16)17/h1-2,5-6,8,12H,3-4H2,(H,18,19)(H,20,21)(H,10,13,14)(H2,15,16,17)/t5-,6+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00369 EHMN_ABBREVIATION: C00460
constant: false
is: SBO:0000247
name: dUTP
boundary condition: false
is: HMDB01191
has only substance units: false

metaR URATEt
type: Reaction
reactant: MODEL1310110045#
is described by: ECO:0000000
fast: false
product: MODEL1310110045#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:IT
kinetic law: MODEL1310110045#
name: urate export from cytosol
is: SBO:0000185
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110045#_a312afce_9b89_4520_9e5e_7794e078ca86
boundary condition: true
constant: false
is encoded by: hsa:8694
type: Species
is: O75907
has only substance units: false
initial concentration: NaN
is: SBO:0000252
initial amount: NaN
name: DGAT1

metaR FACOAL2251
type: Reaction
reactant: MODEL1310110045#
product: MODEL1310110045#
name: fatty-acid--CoA ligase
notes: GENE_ASSOCIATION: (2180.1) SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 4 AUTHORS: PMID:15292367 NOTES:NJ
kinetic law: MODEL1310110045#
fast: false
reversible: true
modifier: MODEL1310110045#
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/6.2.1.3
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110045#_4b3ef03f_9bfd_40d2_a57f_f60f252f2b51
is: SBO:0000252
has only substance units: false
is: O75355
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:956
boundary condition: true
constant: false
type: Species
name: ENTPD3

http://identifiers.org/biomodels.db/MODEL1310110045#_097a5655_bfbf_4563_86a2_b1ff2af7a0d8
is: SBO:0000252
constant: false
is encoded by: hsa:2108
initial amount: NaN
initial concentration: NaN
is: P13804
type: Species
has only substance units: false
name: ETFA
boundary condition: true

metaM CE0713 m
constant: false
notes: FORMULA: C39H60N7O18P3S CHARGE: -4 INCHI: InChI=1/C39H64N7O18P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-27(47)22-30(49)68-21-20-41-29(48)18-19-42-37(52)34(51)39(2,3)24-61-67(58,59)64-66(56,57)60-23-28-33(63-65(53,54)55)32(50)38(62-28)46-26-45-31-35(40)43-25-44-36(31)46/h8-9,11-12,25-26,28,32-34,38,50-51H,4-7,10,13-24H2,1-3H3,(H,41,48)(H,42,52)(H,56,57)(H,58,59)(H2,40,43,44)(H2,53,54,55)/p-4/b9-8-,12-11-/t28-,32+,33+,34u,38-/m0/s1 EHMN_ABBREVIATION: CE0713
initial amount: NaN
type: Species
is: SBO:0000247
is: CHEBI:30623
name: 3-oxolinoleoyl-CoA
initial concentration: 1.0
boundary condition: false
is: HMDB02329
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110045#_320daadf_00c0_4219_a484_0d045fdce8b9
initial concentration: NaN
type: Species
boundary condition: true
has only substance units: false
is: SBO:0000252
is encoded by: hsa:2348
initial amount: NaN
name: FOLR1
constant: false

metaR G14T17g
name: beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase, Golgi
product: MODEL1310110045#
notes: GENE_ASSOCIATION: (8703.1) or (8704.2) or (8704.1) or (2683.1) or (9334.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.38 Confidence Level: 4 AUTHORS: PMID:12512857,PMID:1903938,PMID:3094506,PMID:3144273,PMID:9405390,PMID:9435216 NOTES:Keratan sulfate I biosynthesis NCD
is version of: http://identifiers.org/ec-code/2.4.1.90
fast: false
reversible: false
type: Reaction
is version of: http://identifiers.org/ec-code/2.4.1.22
is described by: ECO:0000000
reactant: MODEL1310110045#
kinetic law: MODEL1310110045#
modifier: MODEL1310110045#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.4.1.38

metaM 3mlda e
is: SBO:0000247
is: http://identifiers.org/pubchem.compound/8122
constant: false
is: HMDB02820
type: Species
is: C05828
notes: FORMULA: C6H7N2O2 CHARGE: -1 INCHI: InChI=1/C6H8N2O2/c1-8-3-5(7-4-8)2-6(9)10/h3-4H,2H2,1H3,(H,9,10) EHMN_ABBREVIATION: C05828
initial concentration: 1.0
name: 3-Methylimidazoleacetic acid
boundary condition: false
has only substance units: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110045#_515619c6_9529_4a64_af2b_f7f669ea6cc6
initial concentration: NaN
is: E5KSL5
boundary condition: true
type: Species
initial amount: NaN
is: SBO:0000252
is encoded by: hsa:1716
has only substance units: false
name: DGUOK
constant: false

metaM hco3 e
initial concentration: 1.0
boundary condition: false
is: CHEBI:17544
is: HMDB00595
is: C00288
name: Bicarbonate
has only substance units: false
constant: false
is: SBO:0000247
notes: FORMULA: CHO3 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00253 EHMN_ABBREVIATION: C00288
type: Species
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110045#_c00122b3_1ed2_4301_9401_22fcbd87be7a
name: DCTD
initial amount: NaN
is: P32321
type: Species
is: SBO:0000252
boundary condition: true
is encoded by: hsa:1635
has only substance units: false
initial concentration: NaN
constant: false

metaM hexe3coa m
has only substance units: false
initial amount: NaN
is: SBO:0000247
name: 3-hexenoylcoa
type: Species
notes: FORMULA: C27H40N7O17P3S CHARGE: -4
is: HMDB06522
boundary condition: false
constant: false
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110045#_c83719dd_a1b9_4891_b8ce_b56ec3ea5b97
type: Species
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:226
is: P04075
has only substance units: false
initial amount: NaN
constant: false
boundary condition: true
name: ALDOA

metaM chsterol l
is: SBO:0000247
initial concentration: 1.0
constant: false
is: CHEBI:16113
boundary condition: false
type: Species
notes: FORMULA: C27H46O CHARGE: 0 INCHI: InChI=1S/C27H46O/c1-18(2)7-6-8-19(3)23-11-12-24-22-10-9-20-17-21(28)13-15-26(20,4)25(22)14-16-27(23,24)5/h9,18-19,21-25,28H,6-8,10-17H2,1-5H3/t19-,21+,22+,23-,24+,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00178 EHMN_ABBREVIATION: C00187
has only substance units: false
is: HMDB00067
name: cholesterol
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110045#_37e11975_9b19_4fda_9a4d_fc1cff7c7ba7
is encoded by: hsa:5151
initial concentration: NaN
boundary condition: true
initial amount: NaN
name: PDE8A
is: O60658
is: SBO:0000252
type: Species
constant: false
has only substance units: false

metaR r1434
kinetic law: MODEL1310110045#
fast: false
product: MODEL1310110045#
is described by: ECO:0000000
reactant: MODEL1310110045#
type: Reaction
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:12930836,PMID:16288981,PMID:911815 NOTES:
name: Transport reaction
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110045#_933920d3_593c_4f85_852b_99c615362fa7
constant: false
name: _AI971023_1_c
has only substance units: false
is: SBO:0000252
boundary condition: true
initial amount: NaN
initial concentration: NaN
type: Species
is encoded by: hsa:AI971023

http://identifiers.org/biomodels.db/MODEL1310110045#_3ec15d11_383a_4ae0_840f_ff20d75297a6
name: PDE7A
boundary condition: true
is: SBO:0000252
constant: false
type: Species
has only substance units: false
initial amount: NaN
is encoded by: hsa:5150
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110045#_2c32a65e_91f6_4814_a45b_9622c22fde8f
boundary condition: true
initial concentration: NaN
constant: false
is encoded by: hsa:AA526438
type: Species
initial amount: NaN
has only substance units: false
name: _AA526438_1_c
is: SBO:0000252

metaR RE2799C
type: Reaction
reactant: MODEL1310110045#
fast: false
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Eicosanoid metabolism EC Number: 1.1.1.188 Confidence Level: 0 AUTHORS: PMID:12543809,PMID:7948008 NOTES:
name: RE2799
product: MODEL1310110045#
is: SBO:0000176
reversible: true
kinetic law: MODEL1310110045#

metaM lnlncgcoa c
notes: FORMULA: C39H60N7O17P3S CHARGE: -4 INCHI: InChI=1S/C39H64N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-30(48)67-23-22-41-29(47)20-21-42-37(51)34(50)39(2,3)25-60-66(57,58)63-65(55,56)59-24-28-33(62-64(52,53)54)32(49)38(61-28)46-27-45-31-35(40)43-26-44-36(31)46/h8-9,11-12,14-15,26-28,32-34,38,49-50H,4-7,10,13,16-25H2,1-3H3,(H,41,47)(H,42,51)(H,55,56)(H,57,58)(H2,40,43,44)(H2,52,53,54)/p-4/b9-8-,12-11-,15-14-/t28-,32-,33-,34+,38-/m1/s1 EHMN_ABBREVIATION: C03035
has only substance units: false
is: SBO:0000247
constant: false
name: gamma-linolenoyl-CoA(4-)
type: Species
is: HMDB06368
is: CHEBI:57363
initial amount: NaN
initial concentration: 1.0
boundary condition: false

metaR 4NPHSULT
name: 4-Nitrophenol Sulfotransferase
reactant: MODEL1310110045#
type: Reaction
is version of: http://identifiers.org/ec-code/2.8.2.1
product: MODEL1310110045#
kinetic law: MODEL1310110045#
fast: false
is: SBO:0000176
is described by: ECO:0000269
reversible: false
modifier: MODEL1310110045#
notes: GENE_ASSOCIATION: (6799.1) or (6817.3) or (6799.2) or (6818.2) or (6817.2) or (6818.1) or (6817.1) or (6817.4) or (6818.3) or (6817.5) SUBSYSTEM: Cytochrome metabolism EC Number: 2.8.2.1 Confidence Level: 4 AUTHORS: PMID:11535246,PMID:15293241 NOTES:RS/TV (6/14/05)

http://identifiers.org/biomodels.db/MODEL1310110045#_09e44054_cb11_4be9_90bb_3b731cb1ddf6
has only substance units: false
constant: false
type: Species
initial amount: NaN
is: SBO:0000252
boundary condition: true
is: Q96FL9
name: GALNT14
initial concentration: NaN
is encoded by: hsa:79623

metaM 2docohexecoa m
initial amount: NaN
initial concentration: 1.0
is: HMDB06294
constant: false
notes: FORMULA: C43H62N7O17P3S CHARGE: -4
name: 2,7,10,13,16,19-docosahexenoylcoa
type: Species
is: SBO:0000247
has only substance units: false
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110045#_1e6badea_76a3_4670_a3dc_d74c4f8fe656
initial amount: NaN
is encoded by: hsa:2110
has only substance units: false
initial concentration: NaN
name: ETFDH
boundary condition: true
type: Species
is: Q16134
is: SBO:0000252
constant: false

http://identifiers.org/biomodels.db/MODEL1310110045#_b8a0ad2f_df16_46ad_a753_8f5a06a9873c
boundary condition: true
initial amount: NaN
has only substance units: false
is encoded by: hsa:26289
constant: false
is: SBO:0000252
type: Species
initial concentration: NaN
name: AK5

http://identifiers.org/biomodels.db/MODEL1310110045#_6bfc8587_7921_4abb_b795_3db88a535aff
initial concentration: NaN
is: Q9NUB1
is: SBO:0000252
constant: false
is encoded by: hsa:84532
type: Species
has only substance units: false
initial amount: NaN
boundary condition: true
name: ACSS1

metaM tchola e
has only substance units: false
notes: FORMULA: C26H45NO7S CHARGE: 0
initial amount: NaN
type: Species
constant: false
boundary condition: false
is: SBO:0000247
is: HMDB00036
name: taurocholic acid
initial concentration: 1.0

metaM chsterol m
name: cholesterol
type: Species
notes: FORMULA: C27H46O CHARGE: 0 INCHI: InChI=1S/C27H46O/c1-18(2)7-6-8-19(3)23-11-12-24-22-10-9-20-17-21(28)13-15-26(20,4)25(22)14-16-27(23,24)5/h9,18-19,21-25,28H,6-8,10-17H2,1-5H3/t19-,21+,22+,23-,24+,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00178 EHMN_ABBREVIATION: C00187
has only substance units: false
initial concentration: 1.0
is: CHEBI:16113
initial amount: NaN
boundary condition: false
is: SBO:0000247
is: HMDB00067
constant: false

metaM HC02121 c
constant: false
boundary condition: false
type: Species
has only substance units: false
initial amount: NaN
notes: FORMULA: C11H18N3O7S CHARGE: -1 INCHI: InChI=1S/C11H19N3O7S/c12-6(11(20)21)1-2-8(16)14-7(4-22-5-15)10(19)13-3-9(17)18/h6-7,15H,1-5,12H2,(H,13,19)(H,14,16)(H,17,18)(H,20,21)/p-1/t6-,7-/m0/s1 EHMN_ABBREVIATION: C14180
is: SBO:0000247
name: S-(hydroxymethyl)glutathione(1-)
initial concentration: 1.0
is: CHEBI:58758

metaR r0463
reactant: MODEL1310110045#
is described by: ECO:0000000
fast: false
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Cholesterol metabolism EC Number: 2.3.3.10 Confidence Level: 0 AUTHORS: PMID:11087424,PMID:11108725,PMID:1358203,PMID:7893153 NOTES:
kinetic law: MODEL1310110045#
reversible: true
product: MODEL1310110045#
name: (S)-3-Hydroxy-3-methylglutaryl-CoA acetoacetyl-CoA-lyase (CoA-acetylating) Synthesis and degradation of ketone bodies / Valine, leucine and isoleucine degradation / Butanoate metabolism EC:2.3.3.10
type: Reaction

metaM xol7ah3 m
initial concentration: 1.0
notes: FORMULA: C27H48O3 CHARGE: 0 INCHI: InChI=1S/C27H48O3/c1-17(16-28)6-5-7-18(2)21-8-9-22-25-23(11-13-27(21,22)4)26(3)12-10-20(29)14-19(26)15-24(25)30/h17-25,28-30H,5-16H2,1-4H3/t17?,18-,19+,20-,21-,22+,23+,24-,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01453 EHMN_ABBREVIATION: C05444
type: Species
has only substance units: false
is: CHEBI:28540
constant: false
name: 5beta-cholestane-3alpha,7alpha,26-triol
is: SBO:0000247
is: HMDB12455
boundary condition: false
initial amount: NaN

metaR HEX1
product: MODEL1310110045#
reversible: false
kinetic law: MODEL1310110045#
type: Reaction
is: SBO:0000176
name: hexokinase (D-glucose:ATP)
reactant: MODEL1310110045#
is described by: ECO:0000134
modifier: MODEL1310110045#
notes: GENE_ASSOCIATION: (3098.3) or (80201.1) or (2645.3) or (3098.4) or (3099.1) or (2645.2) or (3098.5) or (2645.1) or (3098.1) or (3101.1) or (3098.2) SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: Confidence Level: 2 AUTHORS: NOTES:
is version of: http://identifiers.org/ec-code/2.7.1.1
fast: false
is version of: http://identifiers.org/ec-code/2.7.1.2

metaR PRAGSr
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.1.2.2
type: Reaction
reactant: MODEL1310110045#
product: MODEL1310110045#
notes: GENE_ASSOCIATION: (2618.1) or (2618.2) SUBSYSTEM: Purine synthesis EC Number: Confidence Level: 4 AUTHORS: NOTES:
name: phosphoribosylglycinamide synthase
fast: false
is described by: ECO:0000269
reversible: true
kinetic law: MODEL1310110045#
modifier: MODEL1310110045#

http://identifiers.org/biomodels.db/MODEL1310110045#_3f0e6706_ffcf_4691_a581_1b099931211c
is encoded by: hsa:4728
initial concentration: NaN
boundary condition: true
is: SBO:0000252
initial amount: NaN
has only substance units: false
name: NDUFS8
is: O00217
type: Species
constant: false

http://identifiers.org/biomodels.db/MODEL1310110045#_05c90720_c998_4743_9240_d19bc0ddefaf
has only substance units: false
initial amount: NaN
type: Species
is: Q96C36
name: PYCR2
initial concentration: NaN
constant: false
is: SBO:0000252
boundary condition: true
is encoded by: hsa:29920

metaR SUCCOAPET
kinetic law: MODEL1310110045#
product: MODEL1310110045#
reactant: MODEL1310110045#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: thioesterification of succinyl coa for release into cytosol
type: Reaction

metaM nadh m
is: C00004
has only substance units: false
name: Nicotinamide adenine dinucleotide - reduced
constant: false
is: http://identifiers.org/pubchem.compound/3306
is: CHEBI:57945
is: HMDB01487
boundary condition: false
initial concentration: 1.0
initial amount: NaN
is: SBO:0000247
type: Species

metaR EX xylt LPAREN e RPAREN
kinetic law: MODEL1310110045#
reactant: MODEL1310110045#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for xylitol
type: Reaction

metaR r0464
notes: GENE_ASSOCIATION: SUBSYSTEM: Glutamate metabolism EC Number: 1.2.1.3 Confidence Level: 0 AUTHORS: PMID:10467734,PMID:11790142,PMID:4817964,PMID:8155713,PMID:8645224,PMID:8786138 NOTES:
is described by: ECO:0000000
kinetic law: MODEL1310110045#
name: 4-Aminobutyraldehyde:NAD+ oxidoreductase Urea cycle and metabolism of amino groups EC:1.2.1.3
is: SBO:0000176
product: MODEL1310110045#
reactant: MODEL1310110045#
type: Reaction
reversible: true
fast: false

http://identifiers.org/biomodels.db/MODEL1310110045#_e3128f89_cdd0_49aa_adc2_c92fda64fec6
type: Species
constant: false
has only substance units: false
initial amount: NaN
is: SBO:0000252
name: _728226_1_e
is encoded by: hsa:728226
initial concentration: NaN
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110045#_08735705_934f_4592_aba4_72b5360fbcf1
initial amount: NaN
is encoded by: hsa:5295
type: Species
is: SBO:0000252
initial concentration: NaN
is: E7EX19
name: PIK3R1
has only substance units: false
constant: false
boundary condition: true

metaR RE3079X
type: Reaction
kinetic law: MODEL1310110045#
fast: false
modifier: MODEL1310110045#
product: MODEL1310110045#
is version of: http://identifiers.org/ec-code/6.2.1.3
reversible: true
is described by: ECO:0000000
is: SBO:0000176
notes: GENE_ASSOCIATION: (11001.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 0 AUTHORS: PMID:11356164 NOTES:IT - fixed proton
reactant: MODEL1310110045#
name: RE3079

metaR r1435
reversible: false
product: MODEL1310110045#
kinetic law: MODEL1310110045#
fast: false
reactant: MODEL1310110045#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:12930836,PMID:16288981,PMID:911815 NOTES:
name: Transport reaction
is described by: ECO:0000000
type: Reaction

metaR RE3270C
notes: GENE_ASSOCIATION: SUBSYSTEM: Phosphatidylinositol phosphate metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:7556092 NOTES:IT - fixed proton
is described by: ECO:0000000
reactant: MODEL1310110045#
is: SBO:0000176
product: MODEL1310110045#
fast: false
kinetic law: MODEL1310110045#
name: RE3270
type: Reaction
reversible: true

metaR UGLT
type: Reaction
fast: false
reversible: true
modifier: MODEL1310110045#
product: MODEL1310110045#
is version of: http://identifiers.org/ec-code/2.7.7.12
name: UDPglucose--hexose-1-phosphate uridylyltransferase
notes: GENE_ASSOCIATION: (2592.1) or (2592.3) or (2592.2) SUBSYSTEM: Galactose metabolism EC Number: 2.7.7.12 Confidence Level: 0 AUTHORS: PMID:12923184 NOTES:NCD
kinetic law: MODEL1310110045#
is: SBO:0000176
is described by: ECO:0000000
reactant: MODEL1310110045#

http://identifiers.org/biomodels.db/MODEL1310110045#_1b56cedd_1fcd_439e_bed9_74c2b240ac54
is: SBO:0000252
type: Species
initial amount: NaN
constant: false
name: CDS2
is: O95674
is encoded by: hsa:8760
has only substance units: false
boundary condition: true
initial concentration: NaN

metaM tchola c
type: Species
initial amount: NaN
boundary condition: false
constant: false
notes: FORMULA: C26H45NO7S CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC01378 EHMN_ABBREVIATION: C05122
is: SBO:0000247
is: CHEBI:36257
is: HMDB00036
name: taurocholic acid
initial concentration: 1.0
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110045#_1fcb90d9_212d_4daa_9647_349e451ca1f2
is encoded by: hsa:4718
boundary condition: true
constant: false
type: Species
has only substance units: false
initial amount: NaN
is: Q549M5
is: SBO:0000252
initial concentration: NaN
name: NDUFC2

metaR r0603
reactant: MODEL1310110045#
product: MODEL1310110045#
name: (S)-2-methylbutanoyl-CoA:acceptor 2,3-oxidoreductase Valine, leucine and isoleucine degradation EC:1.3.99.12
kinetic law: MODEL1310110045#
reversible: true
notes: GENE_ASSOCIATION: (AW299740.1) or (1737.1) or (J03866.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 1.3.99.12 Confidence Level: 0 AUTHORS: PMID:6401712 NOTES:
modifier: MODEL1310110045#
is described by: ECO:0000000
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.3.1.12
type: Reaction
fast: false

metaM dgtp c
is: HMDB01440
is: CHEBI:16497
initial concentration: 1.0
notes: FORMULA: C10H12N5O13P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00252 EHMN_ABBREVIATION: C00286
name: dGTP
is: C00286
is: SBO:0000247
type: Species
has only substance units: false
constant: false
initial amount: NaN
boundary condition: false

metaM andrstandn r
initial amount: NaN
type: Species
has only substance units: false
notes: FORMULA: C19H28O2 CHARGE: 0 INCHI: InChI=1S/C19H28O2/c1-18-9-7-13(20)11-12(18)3-4-14-15-5-6-17(21)19(15,2)10-8-16(14)18/h12,14-16H,3-11H2,1-2H3/t12-,14-,15-,16-,18-,19-/m0/s1 EHMN_ABBREVIATION: C00674
name: 5alpha-androstane-3,17-dione
boundary condition: false
initial concentration: 1.0
constant: false
is: CHEBI:15994
is: HMDB00899
is: SBO:0000247

metaR r0604
is: SBO:0000176
type: Reaction
product: MODEL1310110045#
kinetic law: MODEL1310110045#
reversible: false
notes: GENE_ASSOCIATION: (6576.1) SUBSYSTEM: Unassigned EC Number: 2.3.1.168 Confidence Level: 0 AUTHORS: PMID:1943690 NOTES:
fast: false
name: (S)-2-methylbutanoyl-CoA:enzyme N6-(dihydrolipoyl)lysine S-(2-methylbutanoyl)transferase Valine, leucine and isoleucine degradation EC:2.3.1.168
reactant: MODEL1310110045#
is described by: ECO:0000000
modifier: MODEL1310110045#

metaR EX 1glyc hs LPAREN e RPAREN
kinetic law: MODEL1310110045#
reactant: MODEL1310110045#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 1 acyl phosphoglycerol exchange
type: Reaction

metaR EX tsul LPAREN e RPAREN
kinetic law: MODEL1310110045#
reactant: MODEL1310110045#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Thiosulfate exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110045#_59ce1c07_1a2c_40a8_b61d_05d3d35a7afd
is: SBO:0000252
is: Q8IV97
boundary condition: true
type: Species
initial amount: NaN
initial concentration: NaN
has only substance units: false
name: SLC7A5
is encoded by: hsa:8140
constant: false

metaM xylu L c
is: CHEBI:17399
is: SBO:0000247
name: L-xylulose
initial amount: NaN
type: Species
notes: FORMULA: C5H10O5 CHARGE: 0 INCHI: InChI=1S/C5H10O5/c6-1-3(8)5(10)4(9)2-7/h3,5-8,10H,1-2H2/t3-,5+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00267
constant: false
boundary condition: false
is: HMDB00751
has only substance units: false
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110045#_d502afae_e034_4bb1_85b3_d5afffbff661
constant: false
is: SBO:0000252
initial concentration: NaN
has only substance units: false
is encoded by: hsa:157506
name: RDH10
boundary condition: true
initial amount: NaN
type: Species
is: Q8IZV5

metaM digalside hs g
is: SBO:0000247
type: Species
boundary condition: false
has only substance units: false
is: http://identifiers.org/pubchem.compound/8383
initial concentration: 1.0
is: C06126
constant: false
initial amount: NaN
notes: FORMULA: C30H56NO12FULLRCO CHARGE: 0 EHMN_ABBREVIATION: C06126
name: Digalactosylceramide

metaR DITPtn
type: Reaction
name: dITP nuclear transport
reversible: true
product: MODEL1310110045#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: NOTES:NCD
is: SBO:0000185
is described by: ECO:0000000
fast: false
reactant: MODEL1310110045#
kinetic law: MODEL1310110045#

metaM chsterol e
initial amount: NaN
initial concentration: 1.0
has only substance units: false
boundary condition: false
constant: false
is: CHEBI:16113
type: Species
notes: FORMULA: C27H46O CHARGE: 0 INCHI: InChI=1S/C27H46O/c1-18(2)7-6-8-19(3)23-11-12-24-22-10-9-20-17-21(28)13-15-26(20,4)25(22)14-16-27(23,24)5/h9,18-19,21-25,28H,6-8,10-17H2,1-5H3/t19-,21+,22+,23-,24+,25+,26+,27-/m1/s1
is: SBO:0000247
is: HMDB00067
name: cholesterol

http://identifiers.org/biomodels.db/MODEL1310110045#_f889754a_232b_40f2_82fd_0476ef1f6e38
initial amount: NaN
is encoded by: hsa:160851
initial concentration: NaN
has only substance units: false
name: DGKH
constant: false
type: Species
is: Q86XP1
boundary condition: true
is: SBO:0000252

metaR XOL7AONEtr
is described by: ECO:0000000
reversible: true
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: PMID:12840657 NOTES:cholesterol precursor, transport by "diffusion" -> actually beleived to be flip-flop mechanism (PMID: 12840657). NJ
type: Reaction
reactant: MODEL1310110045#
product: MODEL1310110045#
kinetic law: MODEL1310110045#
name: lipid, flip-flop intracellular transport
is: SBO:0000185

metaR RE3006M
is version of: http://identifiers.org/ec-code/4.2.1.17
notes: GENE_ASSOCIATION: (10449.1) or (3032.1) or (3030.1) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.16 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:7775433 NOTES:
kinetic law: MODEL1310110045#
is described by: ECO:0000000
reactant: MODEL1310110045#
product: MODEL1310110045#
reversible: true
modifier: MODEL1310110045#
is version of: http://identifiers.org/ec-code/2.3.1.16
name: RE3006
fast: false
type: Reaction
is: SBO:0000176

metaM dutp c
notes: FORMULA: C9H11N2O14P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00369 EHMN_ABBREVIATION: C00460
is: HMDB01191
constant: false
is: CHEBI:17625
is: C00460
initial concentration: 1.0
initial amount: NaN
boundary condition: false
name: dUTP
type: Species
is: SBO:0000247
has only substance units: false

metaM ksi l
notes: FORMULA: C247H393N17O213S12X CHARGE: -13
is: C00445
has only substance units: false
is: CHEBI:57455
type: Species
initial amount: NaN
initial concentration: 1.0
is: SBO:0000247
name: keratan sulfate I
boundary condition: false
constant: false
is: HMDB01354

http://identifiers.org/biomodels.db/MODEL1310110045#_e772423d_63a1_453e_9770_52f2c9fb78b3
constant: false
has only substance units: false
is: Q99798
is: SBO:0000252
boundary condition: true
is encoded by: hsa:50
name: ACO2
type: Species
initial concentration: NaN
initial amount: NaN

metaM pheacgln c
constant: false
boundary condition: false
notes: FORMULA: C13H16N2O4 CHARGE: 0 INCHI: InChI=1S/C13H16N2O4/c14-11(16)7-6-10(13(18)19)15-12(17)8-9-4-2-1-3-5-9/h1-5,10H,6-8H2,(H2,14,16)(H,15,17)(H,18,19)/p-1/t10-/m0/s1
has only substance units: false
is: SBO:0000247
initial concentration: 1.0
type: Species
is: HMDB06344
initial amount: NaN
name: (2S)-4-carbamoyl-2-(2-phenylacetamido)butanoate
is: CHEBI:58310

metaR ATPH2e
kinetic law: MODEL1310110045#
is version of: http://identifiers.org/ec-code/3.6.1.5
type: Reaction
product: MODEL1310110045#
is version of: http://identifiers.org/ec-code/3.6.1.6
reversible: false
is: SBO:0000176
name: ATP diphosphohydrolase
reactant: MODEL1310110045#
modifier: MODEL1310110045#
notes: GENE_ASSOCIATION: (954.2) or (954.1) or (953.1) or (956.1) or (955.1) or (957.1) SUBSYSTEM: Nucleotide interconversion EC Number: 3.6.1.5 Confidence Level: 4 AUTHORS: PMID:8955160,PMID:9676430 NOTES:IT
fast: false
is described by: ECO:0000269

http://identifiers.org/biomodels.db/MODEL1310110045#_e0103d40_42f9_45bd_bc8e_3f617a7bc6ad
is: SBO:0000252
name: ATG9B
has only substance units: false
is: Q674R7
boundary condition: true
constant: false
type: Species
is encoded by: hsa:285973
initial concentration: NaN
initial amount: NaN

metaM ppcoa c
initial amount: NaN
is: HMDB01275
boundary condition: false
constant: false
has only substance units: false
notes: FORMULA: C24H36N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00101 EHMN_ABBREVIATION: C00100
initial concentration: 1.0
is: C00100
type: Species
is: SBO:0000247
name: Propanoyl-CoA
is: CHEBI:57392

metaR RE1527M
is version of: http://identifiers.org/ec-code/1.1.1.35
name: RE1527
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (3295.1) or (1962.1) or (3033.1) or (3028.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.1.1.35 Confidence Level: 0 AUTHORS: PMID:11451959 NOTES:
is version of: http://identifiers.org/ec-code/4.2.1.107
kinetic law: MODEL1310110045#
reactant: MODEL1310110045#
reversible: true
is: SBO:0000176
fast: false
modifier: MODEL1310110045#
type: Reaction
product: MODEL1310110045#

metaM pail345p hs c
boundary condition: false
constant: false
is: SBO:0000247
name: 1-phosphatidyl-1D-myo-inositol 3,4,5-trisphosphate(7-)
has only substance units: false
is: CHEBI:57836
initial concentration: 1.0
notes: FORMULA: C9H13O18P4FULLRCO2FULLR2CO2 CHARGE: -7 EHMN_ABBREVIATION: C05981
type: Species
initial amount: NaN

metaR L LACt4r
reversible: true
kinetic law: MODEL1310110045#
product: MODEL1310110045#
name: L-lactate reversible transport via sodium symport
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:8476015,PMID:9425115 NOTES:
is described by: ECO:0000000
is: SBO:0000185
type: Reaction
fast: false
reactant: MODEL1310110045#

http://identifiers.org/biomodels.db/MODEL1310110045#_a05ea20d_d1bc_4dcc_ac9e_4ea3c30e91b1
name: NOS1
is: B4DG68
constant: false
is: SBO:0000252
has only substance units: false
type: Species
boundary condition: true
initial concentration: NaN
is encoded by: hsa:4842
initial amount: NaN

metaR FAOXC121C10x
kinetic law: MODEL1310110045#
product: MODEL1310110045#
reactant: MODEL1310110045#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta xoidation(C12:1-->C10)x
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110045#_35ce4e45_de4c_470c_9c9a_a0da0283fa66
constant: false
has only substance units: false
initial concentration: NaN
boundary condition: true
is: SBO:0000252
is encoded by: hsa:5144
type: Species
name: PDE4D
is: Q08499
initial amount: NaN

metaM apoC Lys btn m
initial concentration: 1.0
type: Species
has only substance units: false
initial amount: NaN
is: SBO:0000247
constant: false
boundary condition: false
is: http://identifiers.org/pubchem.compound/7886
notes: FORMULA: C16H27N4O3SX CHARGE: 0
is: HMDB03134
name: Holocarboxylase (biotin covalent bound to Lys residue of apoC)
is: C05552

http://identifiers.org/biomodels.db/MODEL1310110045#_1e7be653_50c1_4f48_a0fa_490ef9b85322
initial concentration: NaN
is encoded by: hsa:219
type: Species
is: P30837
initial amount: NaN
name: ALDH1B1
is: SBO:0000252
boundary condition: true
has only substance units: false
constant: false

metaR RE1516M
is version of: http://identifiers.org/ec-code/1.3.99.13
product: MODEL1310110045#
name: RE1516
type: Reaction
notes: GENE_ASSOCIATION: (33.1) or (51.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.99.13 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:11356167,PMID:8973539 NOTES:
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/1.3.3.6
kinetic law: MODEL1310110045#
reversible: true
fast: false
reactant: MODEL1310110045#
modifier: MODEL1310110045#
is: SBO:0000176

metaM chsterol c
constant: false
has only substance units: false
is: SBO:0000247
type: Species
name: cholesterol
is: CHEBI:16113
boundary condition: false
notes: FORMULA: C27H46O CHARGE: 0 INCHI: InChI=1S/C27H46O/c1-18(2)7-6-8-19(3)23-11-12-24-22-10-9-20-17-21(28)13-15-26(20,4)25(22)14-16-27(23,24)5/h9,18-19,21-25,28H,6-8,10-17H2,1-5H3/t19-,21+,22+,23-,24+,25+,26+,27-/m1/s1
is: HMDB00067
initial amount: NaN
initial concentration: 1.0

metaR NDPK2n
type: Reaction
modifier: MODEL1310110045#
is: SBO:0000176
product: MODEL1310110045#
notes: GENE_ASSOCIATION: (4831.1 and 4830.1) or (4830.2 and 4831.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.6 Confidence Level: 4 AUTHORS: NOTES:Many nucleoside diphosphates (eight described) can act as acceptors. While many ribo- and deoxyribonucleoside triphosphates can act as donors, only ATP is chosen as a donor to minimize the number of total reactions.
is version of: http://identifiers.org/ec-code/2.7.4.6
reversible: true
is described by: ECO:0000269
fast: false
reactant: MODEL1310110045#
kinetic law: MODEL1310110045#
name: nucleoside-diphosphate kinase (ATP:UDP), nuclear

metaM dhcholestanate c
initial concentration: 1.0
type: Species
boundary condition: false
has only substance units: false
name: 3alpha,7alpha-Dihydroxy-5beta-cholestanate
initial amount: NaN
is: HMDB00359
constant: false
is: CHEBI:16577
notes: FORMULA: C27H45O4 CHARGE: -1 INCHI: InChI=1S/C27H46O4/c1-16(6-5-7-17(2)25(30)31)20-8-9-21-24-22(11-13-27(20,21)4)26(3)12-10-19(28)14-18(26)15-23(24)29/h16-24,28-29H,5-15H2,1-4H3,(H,30,31)/t16-,17?,18+,19-,20-,21+,22+,23-,24+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01313 EHMN_ABBREVIATION: C04554
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110045#_2c3e411a_e95a_4dff_b813_aa7becfe2701
is: SBO:0000252
type: Species
initial concentration: NaN
constant: false
boundary condition: true
name: _83530_1_c
is encoded by: hsa:83530
has only substance units: false
initial amount: NaN

metaM ppi x
initial amount: NaN
is: CHEBI:33019
notes: FORMULA: HO7P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00023 EHMN_ABBREVIATION: C00013
is: C00013
initial concentration: 1.0
is: SBO:0000247
is: HMDB00250
constant: false
name: Diphosphate
boundary condition: false
type: Species
has only substance units: false

metaR TCYNTt
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:6351723 NOTES:thiocyanate is found excreted in urine (PMID: 6351723) MM
fast: false
product: MODEL1310110045#
is: SBO:0000185
is described by: ECO:0000000
name: Thiocyanate transport via diffusion (cytosol to extracellular)
kinetic law: MODEL1310110045#
type: Reaction
reactant: MODEL1310110045#
reversible: false

metaR ARGtm
reactant: MODEL1310110045#
kinetic law: MODEL1310110045#
notes: GENE_ASSOCIATION: (83884.1) or (10166.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172 NOTES:TDV
type: Reaction
modifier: MODEL1310110045#
reversible: true
is: SBO:0000185
fast: false
is described by: ECO:0000269
name: arginine mitochondrial transport via ornithine carrier
product: MODEL1310110045#

metaR UMPK4n
name: UMP kinase (GTP),nuclear
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
product: MODEL1310110045#
reactant: MODEL1310110045#
is: SBO:0000176
fast: false
reversible: true
modifier: MODEL1310110045#
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/2.7.4.14
kinetic law: MODEL1310110045#
type: Reaction

metaR 3MOBte
product: MODEL1310110045#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
reversible: true
kinetic law: MODEL1310110045#
fast: false
is described by: ECO:0000134
type: Reaction
is: SBO:0000185
name: Transport of 3-methyl-2-oxobutanoate
reactant: MODEL1310110045#

metaR r2511
reactant: MODEL1310110045#
is: SBO:0000185
fast: false
product: MODEL1310110045#
reversible: true
name: Utilized transport
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:17466261 NOTES:
type: Reaction
kinetic law: MODEL1310110045#
is described by: ECO:0000000

metaM pheacgln e
name: (2S)-4-carbamoyl-2-(2-phenylacetamido)butanoate
is: SBO:0000247
boundary condition: false
initial amount: NaN
notes: FORMULA: C13H16N2O4 CHARGE: 0 INCHI: InChI=1S/C13H16N2O4/c14-11(16)7-6-10(13(18)19)15-12(17)8-9-4-2-1-3-5-9/h1-5,10H,6-8H2,(H2,14,16)(H,15,17)(H,18,19)/p-1/t10-/m0/s1
initial concentration: 1.0
is: HMDB06344
has only substance units: false
is: CHEBI:58310
constant: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110045#_3cf8646a_5901_45ea_98d5_0513e79aadd0
boundary condition: true
is: SBO:0000252
is: Q9Y6M9
has only substance units: false
constant: false
initial concentration: NaN
name: NDUFB9
initial amount: NaN
type: Species
is encoded by: hsa:4715

metaM nadh c
is: http://identifiers.org/pubchem.compound/3306
is: HMDB01487
initial concentration: 1.0
has only substance units: false
type: Species
initial amount: NaN
is: C00004
boundary condition: false
constant: false
name: Nicotinamide adenine dinucleotide - reduced
is: SBO:0000247
is: CHEBI:57945

metaM 2octpencoa m
has only substance units: false
constant: false
type: Species
initial concentration: 1.0
notes: FORMULA: C39H56N7O17P3S CHARGE: -4
is: SBO:0000247
initial amount: NaN
name: 2,6,9,12,15-octadecapentenoylcoa
is: HMDB06294
boundary condition: false

metaR DRPA
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Pentose phosphate pathway EC Number: 4.1.2.4 Confidence Level: 2 AUTHORS: NOTES:
fast: false
product: MODEL1310110045#
name: deoxyribose-phosphate aldolase
type: Reaction
kinetic law: MODEL1310110045#
reactant: MODEL1310110045#
is: SBO:0000176
reversible: false

metaM dgtp e
initial amount: NaN
is: CHEBI:16497
notes: FORMULA: C10H12N5O13P3 CHARGE: -4 INCHI: InChI=1S/C10H16N5O13P3/c11-10-13-8-7(9(17)14-10)12-3-15(8)6-1-4(16)5(26-6)2-25-30(21,22)28-31(23,24)27-29(18,19)20/h3-6,16H,1-2H2,(H,21,22)(H,23,24)(H2,18,19,20)(H3,11,13,14,17)/t4-,5+,6+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00252 EHMN_ABBREVIATION: C00286
initial concentration: 1.0
has only substance units: false
type: Species
boundary condition: false
is: HMDB01440
name: dGTP
is: SBO:0000247
constant: false

metaR SUCCTD
kinetic law: MODEL1310110045#
product: MODEL1310110045#
reactant: MODEL1310110045#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: transport of succinate by diffusion
type: Reaction

metaR EX adn LPAREN e RPAREN
kinetic law: MODEL1310110045#
reactant: MODEL1310110045#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for Adenosine
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110045#_1ad0e56c_3809_4201_8e52_c19068fa4c2d
is: SBO:0000252
is encoded by: hsa:224
initial amount: NaN
has only substance units: false
name: ALDH3A2
type: Species
boundary condition: true
is: P51648
initial concentration: NaN
constant: false

http://identifiers.org/biomodels.db/MODEL1310110045#_8f256e0b_8687_4cbd_b56e_231e06ed1fce
type: Species
boundary condition: true
has only substance units: false
is encoded by: hsa:91373
is: SBO:0000252
constant: false
name: UAP1L1
initial concentration: NaN
initial amount: NaN
is: Q3KQV9

http://identifiers.org/biomodels.db/MODEL1310110045#_381c7ae9_04a7_4145_8e8a_faff18cbe41b
boundary condition: true
has only substance units: false
is: SBO:0000252
initial amount: NaN
type: Species
is: Q5QPH3
constant: false
initial concentration: NaN
is encoded by: hsa:55902
name: ACSS2

metaR r2391
type: Reaction
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
kinetic law: MODEL1310110045#
is described by: ECO:0000000
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172 NOTES:
reactant: MODEL1310110045#
product: MODEL1310110045#
fast: false
reversible: false

metaR BACCL
reactant: MODEL1310110045#
modifier: MODEL1310110045#
notes: GENE_ASSOCIATION: (3141.1) SUBSYSTEM: Biotin metabolism EC Number: 6.3.4.15 Confidence Level: 4 AUTHORS: PMID:12459313,PMID:7842009 NOTES:IT
is version of: http://identifiers.org/ec-code/6.3.4.10
kinetic law: MODEL1310110045#
product: MODEL1310110045#
name: biotin-[acetyl-CoA-carboxylase] ligase
type: Reaction
is: SBO:0000176
is described by: ECO:0000269
reversible: false
fast: false

http://identifiers.org/biomodels.db/MODEL1310110045#_92a5854a_b7a7_4f20_90e2_4514eb63e373
is encoded by: hsa:1103
has only substance units: false
is: P28329
boundary condition: true
type: Species
name: CHAT
initial amount: NaN
is: SBO:0000252
constant: false
initial concentration: NaN

metaR ACACT1r
kinetic law: MODEL1310110045#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.3.1.9
fast: false
is described by: ECO:0000000
modifier: MODEL1310110045#
reversible: true
name: acetyl-CoA C-acetyltransferase
type: Reaction
notes: GENE_ASSOCIATION: (39.1) SUBSYSTEM: Tryptophan metabolism EC Number: 2.3.1.9 Confidence Level: 0 AUTHORS: NOTES:JLR- reversible form of ACACT1
reactant: MODEL1310110045#
product: MODEL1310110045#

metaR VITD3t2
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:I am not sure how vitamin D3 is taken up from peripheral cells based on Vitamins, G.F.M. Ball,2004, Blackwell publishing, 1st ed (book) pg.193 IT
fast: false
product: MODEL1310110045#
type: Reaction
reversible: false
kinetic law: MODEL1310110045#
is: SBO:0000185
name: Vitamin D3 uptake
is described by: ECO:0000000
reactant: MODEL1310110045#

metaR G13MT L
reactant: MODEL1310110045#
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/2.4.1.132
type: Reaction
is: SBO:0000176
notes: GENE_ASSOCIATION: (85365.1) or (85365.2) SUBSYSTEM: N-glycan synthesis EC Number: 2.4.1.132 Confidence Level: 0 AUTHORS: NOTES:NCD
name: Glycolipid 1,3-alpha-D-mannosyltransferase (liver)
kinetic law: MODEL1310110045#
product: MODEL1310110045#
modifier: MODEL1310110045#
fast: false
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110045#_b37a98eb_5665_40be_ac09_a49822549035
initial concentration: NaN
name: AGPAT3
initial amount: NaN
has only substance units: false
is: Q9NRZ7
type: Species
boundary condition: true
is encoded by: hsa:56894
is: SBO:0000252
constant: false

metaR EX leuktrD4 LPAREN e RPAREN
kinetic law: MODEL1310110045#
reactant: MODEL1310110045#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: leukotriene D4 exchange
type: Reaction

metaR ALCD21 L
reactant: MODEL1310110045#
kinetic law: MODEL1310110045#
is version of: http://identifiers.org/ec-code/1.1.1.1
notes: GENE_ASSOCIATION: (130.1) or (125.1) or (125.1 and 124.1) or (128.1) or (126.1) or (284273.2) or (137872.1) or (127.1) or (124.1) or (126.1 and 124.1) or (284273.1) or (125.1 and 126.1) or (131.1) SUBSYSTEM: Pyruvate metabolism EC Number: 1.1.1.1 Confidence Level: 2 AUTHORS: PMID:15987839,PMID:2296157 NOTES:NCD
modifier: MODEL1310110045#
fast: false
reversible: false
is version of: http://identifiers.org/ec-code/1.1.99.24
product: MODEL1310110045#
is described by: ECO:0000304
name: alcohol dehydrogenase (L-1,2-propanediol)
is: SBO:0000176
type: Reaction

metaR FAOXC225C204m
kinetic law: MODEL1310110045#
product: MODEL1310110045#
reactant: MODEL1310110045#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C22:5-->C20:4)m
type: Reaction

metaM mescoa m
is: SBO:0000247
boundary condition: false
has only substance units: false
is: C06028
notes: FORMULA: C26H35N7O19P3S CHARGE: -5 INCHI: InChI=1S/C26H40N7O19P3S/c1-13(8-16(35)36)25(40)56-7-6-28-15(34)4-5-29-23(39)20(38)26(2,3)10-49-55(46,47)52-54(44,45)48-9-14-19(51-53(41,42)43)18(37)24(50-14)33-12-32-17-21(27)30-11-31-22(17)33/h8,11-12,14,18-20,24,37-38H,4-7,9-10H2,1-3H3,(H,28,34)(H,29,39)(H,35,36)(H,44,45)(H,46,47)(H2,27,30,31)(H2,41,42,43)/b13-8+/t14-,18-,19-,20+,24-/m1/s1
constant: false
type: Species
name: Mesaconyl-CoA
is: CHEBI:27969
initial amount: NaN
initial concentration: 1.0

metaR LNLCt
product: MODEL1310110045#
reactant: MODEL1310110045#
is described by: ECO:0000000
reversible: true
name: Linoleic acid (n-C18:2) transport in via diffusion
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11788354,PMID:12864740 NOTES:NJ
is: SBO:0000185
kinetic law: MODEL1310110045#
fast: false
type: Reaction

metaM lthstrl r
initial amount: NaN
has only substance units: false
type: Species
name: 5alpha-cholest-7-en-3beta-ol
constant: false
boundary condition: false
initial concentration: 1.0
notes: FORMULA: C27H46O CHARGE: 0 INCHI: InChI=1S/C27H46O/c1-18(2)7-6-8-19(3)23-11-12-24-22-10-9-20-17-21(28)13-15-26(20,4)25(22)14-16-27(23,24)5/h10,18-21,23-25,28H,6-9,11-17H2,1-5H3/t19-,20+,21+,23-,24+,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00706 EHMN_ABBREVIATION: C01189
is: SBO:0000247
is: HMDB01170
is: CHEBI:17168

http://identifiers.org/biomodels.db/MODEL1310110045#_82a2480f_010e_459b_8e73_fefb91117afc
initial amount: NaN
initial concentration: NaN
type: Species
constant: false
name: _AI440329_1_r
is: SBO:0000252
boundary condition: true
has only substance units: false
is encoded by: hsa:AI440329

metaM nrvnc e
boundary condition: false
is: CHEBI:32392
is: SBO:0000247
is: HMDB02368
initial concentration: 1.0
notes: FORMULA: C24H45O2 CHARGE: -1 INCHI: InChI=1S/C24H46O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-24(25)26/h9-10H,2-8,11-23H2,1H3,(H,25,26)/p-1/b10-9-
initial amount: NaN
constant: false
has only substance units: false
name: nervonate
type: Species

http://identifiers.org/biomodels.db/MODEL1310110045#_50ef4325_3771_4df6_ab40_8b8fa9f03299
constant: false
boundary condition: true
has only substance units: false
is: Q99519
initial amount: NaN
is: SBO:0000252
is encoded by: hsa:4758
type: Species
initial concentration: NaN
name: NEU1

metaR ADNt
kinetic law: MODEL1310110045#
type: Reaction
product: MODEL1310110045#
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (3177.1) or (2030.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10722669,PMID:12838422 NOTES:IT
is: SBO:0000185
modifier: MODEL1310110045#
reversible: true
reactant: MODEL1310110045#
name: adenosine facilated transport in cytosol
fast: false

metaR ACACT1x
product: MODEL1310110045#
type: Reaction
is described by: ECO:0000134
is version of: http://identifiers.org/ec-code/2.3.1.9
name: acetyl-CoA C-acetyltransferase, mitochondrial
kinetic law: MODEL1310110045#
fast: false
notes: GENE_ASSOCIATION: (39.1) SUBSYSTEM: Cholesterol metabolism EC Number: 2.3.1.9 Confidence Level: 4 AUTHORS: PMID:11108725 NOTES:NCD NJ - added peroxisomal version
reactant: MODEL1310110045#
reversible: false
is: SBO:0000176
modifier: MODEL1310110045#

metaR DURIt
kinetic law: MODEL1310110045#
product: MODEL1310110045#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10899995 NOTES:
fast: false
reversible: true
type: Reaction
reactant: MODEL1310110045#
name: deoxyuridine transport via diffusion
is: SBO:0000185
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110045#_d590dff0_ce96_4f5b_babc_eb6dd369c109
is encoded by: hsa:3420
initial concentration: NaN
initial amount: NaN
boundary condition: true
is: SBO:0000252
name: IDH3B
constant: false
type: Species
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110045#_076a2990_b2db_42bc_845d_afc4280eec41
has only substance units: false
initial amount: NaN
is encoded by: hsa:128
initial concentration: NaN
type: Species
constant: false
boundary condition: true
is: Q6IRT1
name: ADH5
is: SBO:0000252

metaM core6 l
constant: false
boundary condition: false
notes: FORMULA: C16H27N2O10X CHARGE: 0
name: Core 6
is: SBO:0000247
is: HMDB00143
initial concentration: 1.0
has only substance units: false
is: CHEBI:12936
type: Species
initial amount: NaN

metaM core2 g
name: Core 2
has only substance units: false
constant: false
initial amount: NaN
type: Species
initial concentration: 1.0
is: SBO:0000247
boundary condition: false
notes: FORMULA: C22H37N2O15X CHARGE: 0
is: CHEBI:15876

http://identifiers.org/biomodels.db/MODEL1310110045#_4b784431_bb1d_4db7_92cc_aa1e17a52f42
boundary condition: true
type: Species
has only substance units: false
initial concentration: NaN
is: SBO:0000252
initial amount: NaN
constant: false
name: _AI971036_1_m
is encoded by: hsa:AI971036

metaR r0354
fast: false
notes: GENE_ASSOCIATION: (AA788780.1) or (AA977580.1) or (2180.1) or (2181.1) or (2182.1) or (51703.1) or (23305.1) or (AI694761.1) or (AI915649.1) or (AL525798.1) or (AV727634.1) or (728637.1) or (LOC728997.1) or (11001.1) SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: 2.7.1.1 Confidence Level: 0 AUTHORS: PMID:16906315,PMID:7061426,PMID:7150652,PMID:8717435 NOTES:
type: Reaction
reversible: false
kinetic law: MODEL1310110045#
is described by: ECO:0000000
product: MODEL1310110045#
is version of: http://identifiers.org/ec-code/6.2.1.3
modifier: MODEL1310110045#
is: SBO:0000176
reactant: MODEL1310110045#
name: Glycolysis / Glyconeogenesis EC:2.7.1.1

metaR BAAT2x
is version of: http://identifiers.org/ec-code/2.3.1.65
name: bile acid Coenzyme A: amino acid N-acyltransferase
is described by: ECO:0000269
reversible: false
kinetic law: MODEL1310110045#
is: SBO:0000176
fast: false
reactant: MODEL1310110045#
product: MODEL1310110045#
modifier: MODEL1310110045#
notes: GENE_ASSOCIATION: (570.1) SUBSYSTEM: Bile acid synthesis EC Number: 2.3.1.65 Confidence Level: 4 AUTHORS: NOTES:glycine or taurine as substrates, produces glycocholic or taurocholic acids respectively NJ
type: Reaction

metaR MAL Ltx
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 1 AUTHORS: PMID: 17173541 NOTES:added during gap-filling, no evidence for such a reaction. only assumed.
product: MODEL1310110045#
type: Reaction
name: Transport reaction for malate
is described by: ECO:0000134
kinetic law: MODEL1310110045#
reversible: true
is: SBO:0000185
reactant: MODEL1310110045#
fast: false

metaR M16NTg
is version of: http://identifiers.org/ec-code/2.4.1.143
reversible: false
type: Reaction
notes: GENE_ASSOCIATION: (4247.1) SUBSYSTEM: N-glycan synthesis EC Number: 2.4.1.143 Confidence Level: 0 AUTHORS: PMID:12621063 NOTES:NCD
name: alpha-1,6-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase
reactant: MODEL1310110045#
modifier: MODEL1310110045#
is described by: ECO:0000000
product: MODEL1310110045#
is: SBO:0000176
kinetic law: MODEL1310110045#
fast: false

metaR HISSNAT5tc
kinetic law: MODEL1310110045#
product: MODEL1310110045#
reactant: MODEL1310110045#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: Transport of L-Histidine into the cell coupled with co-transport with Sodium and counter transport with proton by SNAT5 transporter.
type: Reaction

metaR CHATn
type: Reaction
notes: GENE_ASSOCIATION: (1103.4) or (1103.1) or (1103.3) or (1103.2) SUBSYSTEM: Glycerophospholipid metabolism EC Number: 2.3.1.6 Confidence Level: 4 AUTHORS: PMID:10861222 NOTES:NJ
name: Choline O-acetyltransferase
fast: false
reactant: MODEL1310110045#
kinetic law: MODEL1310110045#
is: SBO:0000176
is described by: ECO:0000269
product: MODEL1310110045#
is version of: http://identifiers.org/ec-code/2.3.1.6
reversible: true
modifier: MODEL1310110045#

http://identifiers.org/biomodels.db/MODEL1310110045#_98daf3df_2880_427b_8515_fb2602a4ddf3
has only substance units: false
constant: false
name: COX7A2L
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:9167
is: SBO:0000252
is: Q6FGA0
boundary condition: true
type: Species

metaR HIBDm
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.1.1.31
name: 3-hydroxyisobutyrate dehydrogenase, mitochondrial
product: MODEL1310110045#
reversible: true
reactant: MODEL1310110045#
notes: GENE_ASSOCIATION: (11112.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 1.1.1.31 Confidence Level: 4 AUTHORS: PMID:7527207 NOTES:MM
fast: false
kinetic law: MODEL1310110045#
modifier: MODEL1310110045#
type: Reaction
is described by: ECO:0000269

http://identifiers.org/biomodels.db/MODEL1310110045#_41103ba1_7efe_4279_b2f0_b59adfd9a11f
name: _100128062_1_m
initial concentration: NaN
has only substance units: false
constant: false
type: Species
boundary condition: true
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:100128062

metaM nrvnc c
is: CHEBI:32392
is: SBO:0000247
initial concentration: 1.0
notes: FORMULA: C24H45O2 CHARGE: -1 INCHI: InChI=1S/C24H46O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-24(25)26/h9-10H,2-8,11-23H2,1H3,(H,25,26)/p-1/b10-9-
is: HMDB02368
has only substance units: false
initial amount: NaN
name: nervonate
constant: false
boundary condition: false
type: Species

metaM ksi deg38 l
constant: false
initial concentration: 1.0
notes: FORMULA: C54H91N3O41 CHARGE: 0
has only substance units: false
is: HMDB00143
is: SBO:0000247
boundary condition: false
type: Species
name: keratan sulfate I, degradation product 38
initial amount: NaN
is: CHEBI:12936

metaR PGMT
modifier: MODEL1310110045#
reactant: MODEL1310110045#
notes: GENE_ASSOCIATION: (5236.1) or (55276.1) SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: 5.4.2.2 Confidence Level: 0 AUTHORS: PMID:4829444 NOTES:
type: Reaction
is described by: ECO:0000134
kinetic law: MODEL1310110045#
is version of: http://identifiers.org/ec-code/5.4.2.2
reversible: true
name: phosphoglucomutase
is: SBO:0000176
fast: false
product: MODEL1310110045#

metaR HEX4
modifier: MODEL1310110045#
is: SBO:0000176
product: MODEL1310110045#
reactant: MODEL1310110045#
reversible: false
kinetic law: MODEL1310110045#
is version of: http://identifiers.org/ec-code/2.7.1.2
fast: false
is described by: ECO:0000304
is version of: http://identifiers.org/ec-code/2.7.1.1
name: hexokinase (D-mannose:ATP)
notes: GENE_ASSOCIATION: (3098.2) or (2645.2) or (3098.3) or (2645.3) or (3098.4) or (3099.1) or (3098.5) or (3098.1) or (3101.1) or (80201.1) or (2645.1) SUBSYSTEM: Fructose and mannose metabolism EC Number: 2.7.1.7 Confidence Level: 2 AUTHORS: NOTES:D-Glucose, D-mannose, D-fructose, sorbitol and D-glucosamine can act as acceptors; ITP and dATP can act as donors. The liver isoenzyme has sometimes been called glucokinase. also active in ecoli PMID: 4557975
type: Reaction

metaR r0355
notes: GENE_ASSOCIATION: (AA278423.1) or (48.1) or (50.1) SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: 2.7.1.1 Confidence Level: 0 AUTHORS: PMID:16906315,PMID:7061426,PMID:7150652,PMID:8717435 NOTES:
reactant: MODEL1310110045#
is described by: ECO:0000000
fast: false
modifier: MODEL1310110045#
is version of: http://identifiers.org/ec-code/4.2.1.3
is: SBO:0000176
name: Glycolysis / Glyconeogenesis EC:2.7.1.1
reversible: false
kinetic law: MODEL1310110045#
type: Reaction
product: MODEL1310110045#

http://identifiers.org/biomodels.db/MODEL1310110045#_695d13ad_2a2b_4347_9a9b_5b54c385b4dd
constant: false
name: AMPD2
boundary condition: true
is: Q01433
has only substance units: false
is: SBO:0000252
initial concentration: NaN
type: Species
is encoded by: hsa:271
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110045#_6b543810_3f3f_45a2_81bc_5809506ccda1
initial amount: NaN
is: SBO:0000252
has only substance units: false
initial concentration: NaN
constant: false
type: Species
boundary condition: true
name: _NM_013421_1_e
is encoded by: hsa:NM 013421

http://identifiers.org/biomodels.db/MODEL1310110045#_168e729e_7301_4041_9b64_b5c1e3272f75
name: _W74642_1_c
boundary condition: true
type: Species
initial concentration: NaN
has only substance units: false
initial amount: NaN
is encoded by: hsa:W74642
is: SBO:0000252
constant: false

metaR PROSTGE1t
type: Reaction
reactant: MODEL1310110045#
notes: GENE_ASSOCIATION: (6578.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12507753,PMID:8787677,PMID:9334206 NOTES:NJ
modifier: MODEL1310110045#
is: SBO:0000185
name: prostaglandin transport via bicarbonate countertransport
product: MODEL1310110045#
kinetic law: MODEL1310110045#
fast: false
reversible: true
is described by: ECO:0000269

metaR CYSGLTH
kinetic law: MODEL1310110045#
is described by: ECO:0000000
fast: false
name: Glutathione:cystine oxidoreductase
reactant: MODEL1310110045#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Methionine and cysteine metabolism EC Number: 1.8.4.4 Confidence Level: 4 AUTHORS: PMID:15189131,PMID:932033 NOTES:reaction according to KEGG MM
is: SBO:0000176
reversible: true
product: MODEL1310110045#

metaR GALASE6ly
modifier: MODEL1310110045#
product: MODEL1310110045#
is version of: http://identifiers.org/ec-code/3.2.1.23
is version of: http://identifiers.org/ec-code/3.1.6.4
name: beta-galactosidase, lysosomal
is described by: ECO:0000000
reversible: false
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) or (5476.1) and (2720.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.23 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD
type: Reaction
reactant: MODEL1310110045#
is version of: http://identifiers.org/ec-code/3.2.1.18
is version of: http://identifiers.org/ec-code/3.4.16.5
fast: false
kinetic law: MODEL1310110045#
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110045#_d8b53461_c144_423f_884c_423a964d2aef
boundary condition: true
initial concentration: NaN
name: SYNJ2
type: Species
is: SBO:0000252
is: O15056
constant: false
is encoded by: hsa:8871
has only substance units: false
initial amount: NaN

metaR r2375
is: SBO:0000185
kinetic law: MODEL1310110045#
is described by: ECO:0000000
product: MODEL1310110045#
type: Reaction
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:16919238,PMID:17173541,PMID:18406340,PMID:8132483 NOTES:
reactant: MODEL1310110045#
fast: false
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110045#_26920f44_d1a1_43eb_aeab_2502171bccee
has only substance units: false
name: _AI926493_1_c
constant: false
is encoded by: hsa:AI926493
type: Species
initial amount: NaN
initial concentration: NaN
boundary condition: true
is: SBO:0000252

metaM retinol cis 11 e
constant: false
name: 11-cis-retinol
is: CHEBI:16302
has only substance units: false
initial concentration: 1.0
notes: FORMULA: C20H30O CHARGE: 0 INCHI: InChI=1S/C20H30O/c1-16(8-6-9-17(2)13-15-21)11-12-19-18(3)10-7-14-20(19,4)5/h6,8-9,11-13,21H,7,10,14-15H2,1-5H3/b9-6-,12-11+,16-8+,17-13+
initial amount: NaN
type: Species
is: SBO:0000247
is: HMDB06216
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110045#_29ce5fd0_043d_422f_a779_81c9f1010535
is: SBO:0000252
boundary condition: true
initial amount: NaN
initial concentration: NaN
type: Species
is: Q9NVE7
constant: false
name: PANK4
is encoded by: hsa:55229
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110045#_13d4c602_c56e_41a3_bc18_a9dd24e0746d
name: ACP5
initial amount: NaN
has only substance units: false
constant: false
initial concentration: NaN
type: Species
is: P13686
is encoded by: hsa:54
is: SBO:0000252
boundary condition: true

metaM ksi pre34 g
boundary condition: false
constant: false
notes: FORMULA: C241H385N17O202S10X CHARGE: -11
is: CHEBI:58053
has only substance units: false
initial concentration: 1.0
initial amount: NaN
is: C00130
type: Species
name: keratan sulfate I biosynthesis, precursor 34
is: HMDB00175
is: SBO:0000247

metaR FACOAL224
is: SBO:0000176
modifier: MODEL1310110045#
kinetic law: MODEL1310110045#
fast: false
name: fatty-acid--CoA ligase
is version of: http://identifiers.org/ec-code/6.2.1.3
notes: GENE_ASSOCIATION: (2180.1) SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 4 AUTHORS: PMID:15292367 NOTES:NJ
type: Reaction
product: MODEL1310110045#
is described by: ECO:0000000
reversible: true
reactant: MODEL1310110045#

metaM retinal r
name: retinal
initial concentration: 1.0
is: SBO:0000247
boundary condition: false
initial amount: NaN
constant: false
is: CHEBI:15035
notes: FORMULA: C20H28O CHARGE: 0 INCHI: InChI=1S/C20H28O/c1-16(8-6-9-17(2)13-15-21)11-12-19-18(3)10-7-14-20(19,4)5/h6,8-9,11-13,15H,7,10,14H2,1-5H3 EHMN_ABBREVIATION: C00376
type: Species
has only substance units: false
is: HMDB01358

metaR GLUTCOADHm
notes: GENE_ASSOCIATION: (2639.1) or (2639.2) SUBSYSTEM: Tryptophan metabolism EC Number: 1.3.99.7 Confidence Level: 2 AUTHORS: NOTES:SAB use of FAD is not certain
type: Reaction
name: glutaryl-CoA dehydrogenase (mitochondria)
reversible: false
modifier: MODEL1310110045#
reactant: MODEL1310110045#
is: SBO:0000176
fast: false
is version of: http://identifiers.org/ec-code/1.3.99.7
is described by: ECO:0000304
kinetic law: MODEL1310110045#
product: MODEL1310110045#

metaR r1592
fast: false
reactant: MODEL1310110045#
kinetic law: MODEL1310110045#
is: SBO:0000185
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
type: Reaction
is described by: ECO:0000000
product: MODEL1310110045#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1

metaR r2374
product: MODEL1310110045#
reversible: true
reactant: MODEL1310110045#
is described by: ECO:0000000
fast: false
type: Reaction
is: SBO:0000185
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:16919238,PMID:17173541,PMID:18406340,PMID:8132483 NOTES:
kinetic law: MODEL1310110045#

http://identifiers.org/biomodels.db/MODEL1310110045#_daf3af75_8b57_4521_aed9_340ef64ffbef
boundary condition: true
is encoded by: hsa:3098
name: HK1
is: SBO:0000252
initial concentration: NaN
initial amount: NaN
type: Species
has only substance units: false
constant: false
is: P78542

http://identifiers.org/biomodels.db/MODEL1310110045#_f70d0a92_70bf_4db6_9855_a34192f32c61
constant: false
initial concentration: NaN
initial amount: NaN
is: SBO:0000252
has only substance units: false
type: Species
boundary condition: true
name: CHST6
is: Q9GZX3
is encoded by: hsa:4166

metaM tag hs e
type: Species
initial amount: NaN
has only substance units: false
notes: FORMULA: C3H5FULLRCO2FULLR2CO2FULLR3CO2 CHARGE: 0
name: triglyceride
initial concentration: 1.0
constant: false
is: SBO:0000247
is: CHEBI:17855
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110045#_8774f83e_8c9e_48c8_a95a_76fc073fcebe
is encoded by: hsa:4357
boundary condition: true
initial amount: NaN
constant: false
is: P25325
has only substance units: false
type: Species
name: MPST
initial concentration: NaN
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110045#_e2f5093a_520f_435f_9552_bb8734d8cbbf
has only substance units: false
initial amount: NaN
boundary condition: true
type: Species
is encoded by: hsa:6342
is: SBO:0000252
initial concentration: NaN
constant: false
name: SCP2
is: C9JC79

metaR DHFtl
reactant: MODEL1310110045#
is described by: ECO:0000000
reversible: true
is: SBO:0000185
name: dihydrofolate reversible lysosomal transport
kinetic law: MODEL1310110045#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 2 AUTHORS: PMID:11375437 NOTES:NCD,IT
product: MODEL1310110045#
type: Reaction

metaR r1593
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
kinetic law: MODEL1310110045#
is: SBO:0000185
product: MODEL1310110045#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
fast: false
reactant: MODEL1310110045#
type: Reaction
reversible: true
is described by: ECO:0000000

metaR FAEL204
kinetic law: MODEL1310110045#
is described by: ECO:0000000
reversible: false
is: SBO:0000176
reactant: MODEL1310110045#
fast: false
modifier: MODEL1310110045#
name: fatty-acyl-CoA elongation (n-C20:4CoA)
product: MODEL1310110045#
type: Reaction
notes: GENE_ASSOCIATION: (6785.1) SUBSYSTEM: Fatty acid synthesis EC Number: 2.3.1.86 Confidence Level: 4 AUTHORS: PMID:11138005,PMID:15189125 NOTES:fatty acid elongation step NJ

metaR r1746
fast: false
is described by: ECO:0000000
type: Reaction
reversible: false
is: SBO:0000185
name: Y+LAT2 Utilized transport
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reactant: MODEL1310110045#
product: MODEL1310110045#
kinetic law: MODEL1310110045#
modifier: MODEL1310110045#

metaR r2373
is: SBO:0000185
product: MODEL1310110045#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:16919238,PMID:17173541,PMID:18406340,PMID:8132483 NOTES:
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
type: Reaction
reactant: MODEL1310110045#
reversible: true
fast: false
kinetic law: MODEL1310110045#

metaM retinol cis 11 c
type: Species
is: CHEBI:16302
initial concentration: 1.0
boundary condition: false
notes: FORMULA: C20H30O CHARGE: 0 INCHI: InChI=1S/C20H30O/c1-16(8-6-9-17(2)13-15-21)11-12-19-18(3)10-7-14-20(19,4)5/h6,8-9,11-13,21H,7,10,14-15H2,1-5H3/b9-6-,12-11+,16-8+,17-13+
has only substance units: false
is: SBO:0000247
name: 11-cis-retinol
initial amount: NaN
is: HMDB06216
constant: false

http://identifiers.org/biomodels.db/MODEL1310110045#_23d5ea95_61b3_42a0_8d83_f58f7863341f
initial concentration: NaN
is: Q9NY64
name: SLC2A8
type: Species
is encoded by: hsa:29988
constant: false
boundary condition: true
has only substance units: false
initial amount: NaN
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110045#_b660dd89_512b_4837_b80f_ebb1f0dbe2f5
is: P51178
initial concentration: NaN
boundary condition: true
name: PLCD1
is: SBO:0000252
constant: false
type: Species
is encoded by: hsa:5333
has only substance units: false
initial amount: NaN

metaM ctp m
type: Species
boundary condition: false
has only substance units: false
notes: FORMULA: C9H12N3O14P3 CHARGE: -4 INCHI: InChI=1S/C9H16N3O14P3/c10-5-1-2-12(9(15)11-5)8-7(14)6(13)4(24-8)3-23-28(19,20)26-29(21,22)25-27(16,17)18/h1-2,4,6-8,13-14H,3H2,(H,19,20)(H,21,22)(H2,10,11,15)(H2,16,17,18)/p-4/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00066 EHMN_ABBREVIATION: C00063
is: HMDB00082
constant: false
initial concentration: 1.0
is: SBO:0000247
initial amount: NaN
name: CTP(4-)
is: CHEBI:37563

metaR MI14P4P
type: Reaction
name: inositol-1,4-bisphosphate 4-phosphatase
reactant: MODEL1310110045#
is: SBO:0000176
product: MODEL1310110045#
notes: GENE_ASSOCIATION: SUBSYSTEM: Inositol phosphate metabolism EC Number: Confidence Level: 2 AUTHORS: PMID:2906139 NOTES:NCD
fast: false
kinetic law: MODEL1310110045#
is described by: ECO:0000000
reversible: false

metaR r1590
type: Reaction
is described by: ECO:0000000
kinetic law: MODEL1310110045#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
product: MODEL1310110045#
reactant: MODEL1310110045#
fast: false
is: SBO:0000185
reversible: true

metaR 2OXOADPTm
type: Reaction
kinetic law: MODEL1310110045#
is: SBO:0000185
reversible: true
modifier: MODEL1310110045#
reactant: MODEL1310110045#
fast: false
notes: GENE_ASSOCIATION: (89874.1) SUBSYSTEM: Tryptophan metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:11083877 NOTES:SAB PMID 11083877
product: MODEL1310110045#
is described by: ECO:0000269
name: 2-oxoadipate shuttle (cytosol/mitochondria)

metaR DHFtm
fast: false
reversible: true
product: MODEL1310110045#
name: dihydrofolate reversible mitochondrial transport
reactant: MODEL1310110045#
is: SBO:0000185
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: PMID:11375437 NOTES:NCD
kinetic law: MODEL1310110045#
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110045#_f03e4ff8_4fe2_414d_b673_aabba17d7803
constant: false
type: Species
is: SBO:0000252
boundary condition: true
has only substance units: false
is encoded by: hsa:8875
initial amount: NaN
initial concentration: NaN
is: O95498
name: VNN2

metaM g6p r
type: Species
is: HMDB01401
is: C00092
initial amount: NaN
is: CHEBI:61548
initial concentration: 1.0
name: D-Glucose 6-phosphate
boundary condition: false
constant: false
notes: FORMULA: C6H11O9P CHARGE: -2 INCHI: "1/C5H11/c1-3-5-4-2/h1,3-5H2,2H3 HEPATONET_1.0_ABBREVIATION: HC00094 EHMN_ABBREVIATION: C00092
has only substance units: false
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110045#_cf777d6e_a1dc_4e6a_b5d3_bf99c0fd1439
is: SBO:0000252
constant: false
is: Q9Y345
initial amount: NaN
has only substance units: false
name: SLC6A5
boundary condition: true
initial concentration: NaN
is encoded by: hsa:9152
type: Species

metaR RE3346C
reactant: MODEL1310110045#
reversible: true
is version of: http://identifiers.org/ec-code/1.2.1.3
kinetic law: MODEL1310110045#
fast: false
notes: GENE_ASSOCIATION: (223.1) or (218.1) SUBSYSTEM: Bile acid synthesis EC Number: 1.2.1.3 Confidence Level: 0 AUTHORS: PMID:1591235 NOTES:
name: RE3346
product: MODEL1310110045#
modifier: MODEL1310110045#
is: SBO:0000176
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/1.2.1.5
type: Reaction

metaM nadph c
has only substance units: false
initial amount: NaN
type: Species
is: SBO:0000247
constant: false
name: Nicotinamide adenine dinucleotide phosphate - reduced
is: HMDB00221
initial concentration: 1.0
notes: FORMULA: C21H26N7O17P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00015 EHMN_ABBREVIATION: C00005
is: CHEBI:57783
is: C00005
boundary condition: false

metaR r2372
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172 NOTES:
reactant: MODEL1310110045#
is described by: ECO:0000000
fast: false
kinetic law: MODEL1310110045#
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
type: Reaction
is: SBO:0000185
product: MODEL1310110045#

http://identifiers.org/biomodels.db/MODEL1310110045#_7424443f_54ff_4776_9dad_c7bea359dfb8
initial concentration: NaN
name: MTMR1
is encoded by: hsa:8776
has only substance units: false
is: SBO:0000252
initial amount: NaN
is: Q13613
constant: false
boundary condition: true
type: Species

metaM chol e
boundary condition: false
is: CHEBI:15354
notes: FORMULA: C5H14NO CHARGE: 1 HEPATONET_1.0_ABBREVIATION: HC00112 EHMN_ABBREVIATION: C00114
is: HMDB00097
initial amount: NaN
type: Species
constant: false
name: Choline
initial concentration: 1.0
has only substance units: false
is: SBO:0000247
is: C00114

http://identifiers.org/biomodels.db/MODEL1310110045#_98513c16_8c9c_4336_a3ad_9300a1c246b8
is encoded by: hsa:80347
has only substance units: false
initial concentration: NaN
boundary condition: true
is: Q13057
name: COASY
constant: false
initial amount: NaN
is: SBO:0000252
type: Species

http://identifiers.org/biomodels.db/MODEL1310110045#_f70a4572_1222_40cb_8387_f4cc216d7934
type: Species
is encoded by: hsa:6487
constant: false
name: ST3GAL3
initial amount: NaN
has only substance units: false
initial concentration: NaN
is: SBO:0000252
boundary condition: true

metaM datp c
name: dATP
notes: FORMULA: C10H12N5O12P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00129 EHMN_ABBREVIATION: C00131
is: HMDB01532
initial amount: NaN
initial concentration: 1.0
is: C00131
type: Species
has only substance units: false
is: SBO:0000247
is: CHEBI:61404
constant: false
boundary condition: false

metaM ctp n
is: SBO:0000247
is: CHEBI:37563
initial amount: NaN
boundary condition: false
name: CTP(4-)
notes: FORMULA: C9H12N3O14P3 CHARGE: -4 INCHI: InChI=1S/C9H16N3O14P3/c10-5-1-2-12(9(15)11-5)8-7(14)6(13)4(24-8)3-23-28(19,20)26-29(21,22)25-27(16,17)18/h1-2,4,6-8,13-14H,3H2,(H,19,20)(H,21,22)(H2,10,11,15)(H2,16,17,18)/p-4/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00066 EHMN_ABBREVIATION: C00063
initial concentration: 1.0
type: Species
has only substance units: false
is: HMDB00082
constant: false

metaR ASPDxt
is: SBO:0000185
product: MODEL1310110045#
type: Reaction
fast: false
is described by: ECO:0000000
name: D-aspartate transport, peroxisomal
reactant: MODEL1310110045#
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: NOTES:MM
kinetic law: MODEL1310110045#

metaR DM anth
kinetic law: MODEL1310110045#
reactant: MODEL1310110045#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: Demand for anthranilate
type: Reaction

metaR DGSNtm
reversible: true
type: Reaction
fast: false
kinetic law: MODEL1310110045#
reactant: MODEL1310110045#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: PMID:3696164 NOTES:
product: MODEL1310110045#
is: SBO:0000185
name: deoyguanosine transport in mitochondria
is described by: ECO:0000000

metaR r1591
reactant: MODEL1310110045#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
type: Reaction
is described by: ECO:0000000
is: SBO:0000185
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
product: MODEL1310110045#
fast: false
reversible: true
kinetic law: MODEL1310110045#

metaM cgly e
is: SBO:0000247
is: HMDB00078
is: CHEBI:4047
initial concentration: 1.0
constant: false
initial amount: NaN
has only substance units: false
type: Species
notes: FORMULA: C5H10N2O3S CHARGE: 0 INCHI: InChI=1S/C5H10N2O3S/c6-3(2-11)5(10)7-1-4(8)9/h3,11H,1-2,6H2,(H,7,10)(H,8,9)/t3-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00784 EHMN_ABBREVIATION: C01419
name: L-cysteinylglycine
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110045#_ad60c74f_ff17_46e2_a229_502ae63f7ac7
initial amount: NaN
is encoded by: hsa:7360
boundary condition: true
type: Species
constant: false
name: UGP2
initial concentration: NaN
is: SBO:0000252
is: Q16851
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110045#_975ca64f_1ef2_47de_8e04_a5e1e708626b
boundary condition: true
is encoded by: hsa:3155
name: HMGCL
is: SBO:0000252
initial amount: NaN
type: Species
has only substance units: false
is: Q6IBC0
constant: false
initial concentration: NaN

metaR r2521
reactant: MODEL1310110045#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:8691743 NOTES:
is: SBO:0000185
is described by: ECO:0000000
type: Reaction
fast: false
name: Utilized transport
product: MODEL1310110045#
kinetic law: MODEL1310110045#
reversible: true

metaR GLUPRT
modifier: MODEL1310110045#
product: MODEL1310110045#
notes: GENE_ASSOCIATION: (5471.1) SUBSYSTEM: Purine synthesis EC Number: 2.4.2.14 Confidence Level: 4 AUTHORS: PMID:8106516,PMID:8380692,PMID:9108165 NOTES:
is: SBO:0000176
fast: false
reactant: MODEL1310110045#
is version of: http://identifiers.org/ec-code/2.4.2.14
name: glutamine phosphoribosyldiphosphate amidotransferase
kinetic law: MODEL1310110045#
reversible: false
is described by: ECO:0000269
type: Reaction

metaR r2379
is described by: ECO:0000000
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
fast: false
product: MODEL1310110045#
kinetic law: MODEL1310110045#
type: Reaction
reactant: MODEL1310110045#
reversible: true
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:16919238,PMID:17173541,PMID:18406340,PMID:8132483 NOTES:

metaM co2 x
is: HMDB01967
name: carbon dioxide
type: Species
initial amount: NaN
boundary condition: false
is: SBO:0000247
notes: FORMULA: CO2 CHARGE: 0 INCHI: InChI=1S/CO2/c2-1-3 HEPATONET_1.0_ABBREVIATION: HC00021 EHMN_ABBREVIATION: C00011
constant: false
is: CHEBI:16526
has only substance units: false
initial concentration: 1.0

metaR EX chsterol LPAREN e RPAREN
kinetic law: MODEL1310110045#
reactant: MODEL1310110045#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for cholesterol
type: Reaction

metaM cdp m
type: Species
initial amount: NaN
notes: FORMULA: C9H12N3O11P2 CHARGE: -3 INCHI: InChI=1S/C9H15N3O11P2/c10-5-1-2-12(9(15)11-5)8-7(14)6(13)4(22-8)3-21-25(19,20)23-24(16,17)18/h1-2,4,6-8,13-14H,3H2,(H,19,20)(H2,10,11,15)(H2,16,17,18)/p-3/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00110 EHMN_ABBREVIATION: C00112
is: CHEBI:58069
name: CDP(3-)
constant: false
is: SBO:0000247
boundary condition: false
is: HMDB01546
initial concentration: 1.0
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110045#_2e9cb1ba_3b07_492b_9e69_078a6b72112a
boundary condition: true
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:10991
initial concentration: NaN
is: Q99624
name: SLC38A3
constant: false
type: Species
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110045#_812d1b71_fd8f_4a7b_bdcf_26ab2ee4c3e2
is: SBO:0000252
type: Species
initial amount: NaN
is: B7Z792
boundary condition: true
initial concentration: NaN
is encoded by: hsa:4720
name: NDUFS2
has only substance units: false
constant: false

http://identifiers.org/biomodels.db/MODEL1310110045#_c87348bd_d8e5_41cc_bdc7_4fdc2fb32699
is: O14975
type: Species
boundary condition: true
name: SLC27A2
has only substance units: false
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:11001
initial concentration: NaN
constant: false

metaR PRO1x
type: Reaction
product: MODEL1310110045#
name: L-ProlineNAD+ 5-oxidoreductase
fast: false
reactant: MODEL1310110045#
reversible: false
is version of: http://identifiers.org/ec-code/1.5.99.8
is: SBO:0000176
is described by: ECO:0000134
notes: GENE_ASSOCIATION: (58510.1) SUBSYSTEM: Transport, extracellular EC Number: 1.5.1.2 Confidence Level: 2 AUTHORS: PMID: 11458019, Sareen S. Gropper, jack L. Smith, James L. Groff (2009) Wadaworth cengage learning, Advanced nutrition and human metabolism, 5th edition, page 194-196 NOTES:
modifier: MODEL1310110045#
kinetic law: MODEL1310110045#

metaR FUMAC
name: fumarylacetoacetase
product: MODEL1310110045#
reactant: MODEL1310110045#
type: Reaction
reversible: false
is version of: http://identifiers.org/ec-code/3.7.1.2
kinetic law: MODEL1310110045#
modifier: MODEL1310110045#
notes: GENE_ASSOCIATION: (2184.1) SUBSYSTEM: Tyrosine metabolism EC Number: 3.7.1.2 Confidence Level: 4 AUTHORS: NOTES:NCD
is: SBO:0000176
is described by: ECO:0000269
fast: false

metaR EX amp LPAREN e RPAREN
kinetic law: MODEL1310110045#
reactant: MODEL1310110045#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: AMP exchange
type: Reaction

metaR r2520
is described by: ECO:0000000
type: Reaction
name: Mitochondrial Carrier (MC) TCDB:2.A.29.2.1
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:15845418 NOTES:
reactant: MODEL1310110045#
is: SBO:0000185
reversible: true
product: MODEL1310110045#
kinetic law: MODEL1310110045#
fast: false

metaR G5SADrm
type: Reaction
name: L-glutamate 5-semialdehyde dehydratase, reversible, mitochondrial
product: MODEL1310110045#
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Arginine and Proline Metabolism EC Number: Confidence Level: 4 AUTHORS: NOTES:spontaneous reaction NCD
fast: false
is: SBO:0000176
kinetic law: MODEL1310110045#
reactant: MODEL1310110045#
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110045#_ca8b9ae4_7883_441c_864a_f18d2b786aa9
initial concentration: NaN
constant: false
initial amount: NaN
name: _LOC374569_1_e
type: Species
has only substance units: false
is encoded by: hsa:LOC374569
boundary condition: true
is: SBO:0000252

metaR r2378
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:16919238,PMID:17173541,PMID:18406340,PMID:8132483 NOTES:
reactant: MODEL1310110045#
is described by: ECO:0000000
is: SBO:0000185
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
type: Reaction
reversible: true
fast: false
product: MODEL1310110045#
kinetic law: MODEL1310110045#

metaR OROTGLUt
name: OROTGLUt
kinetic law: MODEL1310110045#
is described by: ECO:0000134
product: MODEL1310110045#
type: Reaction
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
reactant: MODEL1310110045#
is: SBO:0000185
fast: false

metaR r1749
kinetic law: MODEL1310110045#
name: Y+LAT2 Utilized transport
fast: false
is: SBO:0000185
product: MODEL1310110045#
reversible: false
modifier: MODEL1310110045#
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reactant: MODEL1310110045#
is described by: ECO:0000000
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110045#_b9511a1f_1be2_4a9c_a95c_db4854baed33
constant: false
boundary condition: true
type: Species
is: SBO:0000252
has only substance units: false
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:U52111
name: _U52111_1_c

http://identifiers.org/biomodels.db/MODEL1310110045#_2bc43323_c9e9_4fc2_9b7b_30a0fc7154a1
initial concentration: NaN
is: P12235
type: Species
is: SBO:0000252
initial amount: NaN
name: SLC25A4
constant: false
is encoded by: hsa:291
boundary condition: true
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110045#_4755ae5b_684d_4f9b_b46e_f677dcc0ccf7
type: Species
is encoded by: hsa:AV727634
name: _AV727634_1_c
has only substance units: false
boundary condition: true
is: SBO:0000252
initial amount: NaN
constant: false
initial concentration: NaN

metaM dlnlcgcoa c
constant: false
name: dihomo-gamma-linolenyl coenzyme A
initial amount: NaN
initial concentration: 1.0
is: SBO:0000247
is: CHEBI:27979
type: Species
has only substance units: false
notes: FORMULA: C41H64N7O17P3S CHARGE: -4 INCHI: InChI=1S/C41H68N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-32(50)69-25-24-43-31(49)22-23-44-39(53)36(52)41(2,3)27-62-68(59,60)65-67(57,58)61-26-30-35(64-66(54,55)56)34(51)40(63-30)48-29-47-33-37(42)45-28-46-38(33)48/h8-9,11-12,14-15,28-30,34-36,40,51-52H,4-7,10,13,16-27H2,1-3H3,(H,43,49)(H,44,53)(H,57,58)(H,59,60)(H2,42,45,46)(H2,54,55,56)/b9-8-,12-11-,15-14-/t30-,34-,35-,36+,40-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC02102
boundary condition: false

metaM HC02203 e
type: Species
is: CHEBI:27820
is: SBO:0000247
name: prostaglandin-a2
initial concentration: 1.0
notes: FORMULA: C20H29O4 CHARGE: -1 INCHI: InChI=1S/C20H30O4/c1-2-3-6-9-17(21)14-12-16-13-15-19(22)18(16)10-7-4-5-8-11-20(23)24/h4,7,12-18,21H,2-3,5-6,8-11H2,1H3,(H,23,24)/b7-4-,14-12+/t16-,17-,18+/m0/s1 EHMN_ABBREVIATION: C05953
constant: false
boundary condition: false
has only substance units: false
initial amount: NaN

metaM cdp n
is: HMDB01546
initial concentration: 1.0
name: CDP(3-)
constant: false
is: SBO:0000247
has only substance units: false
is: CHEBI:58069
type: Species
boundary condition: false
initial amount: NaN
notes: FORMULA: C9H12N3O11P2 CHARGE: -3 INCHI: InChI=1S/C9H15N3O11P2/c10-5-1-2-12(9(15)11-5)8-7(14)6(13)4(22-8)3-21-25(19,20)23-24(16,17)18/h1-2,4,6-8,13-14H,3H2,(H,19,20)(H2,10,11,15)(H2,16,17,18)/p-3/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00110 EHMN_ABBREVIATION: C00112

metaM cgly c
is: SBO:0000247
initial concentration: 1.0
name: L-cysteinylglycine
has only substance units: false
initial amount: NaN
boundary condition: false
is: CHEBI:4047
type: Species
constant: false
notes: FORMULA: C5H10N2O3S CHARGE: 0 INCHI: InChI=1S/C5H10N2O3S/c6-3(2-11)5(10)7-1-4(8)9/h3,11H,1-2,6H2,(H,7,10)(H,8,9)/t3-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00784 EHMN_ABBREVIATION: C01419
is: HMDB00078

metaM chol c
name: Choline
is: C00114
initial concentration: 1.0
has only substance units: false
type: Species
is: CHEBI:15354
is: SBO:0000247
initial amount: NaN
constant: false
is: HMDB00097
boundary condition: false
notes: FORMULA: C5H14NO CHARGE: 1 HEPATONET_1.0_ABBREVIATION: HC00112 EHMN_ABBREVIATION: C00114

metaM nadh x
is: CHEBI:57945
name: Nicotinamide adenine dinucleotide - reduced
is: C00004
has only substance units: false
initial concentration: 1.0
constant: false
boundary condition: false
is: HMDB01487
initial amount: NaN
is: http://identifiers.org/pubchem.compound/3306
is: SBO:0000247
type: Species

http://identifiers.org/biomodels.db/MODEL1310110045#_c6d7b885_674e_4cf3_9516_dc8b9568f85c
initial concentration: NaN
has only substance units: false
constant: false
type: Species
is: B7Z6M3
initial amount: NaN
boundary condition: true
name: DGKZ
is encoded by: hsa:8525
is: SBO:0000252

metaM apoC Lys btn c
initial amount: NaN
constant: false
type: Species
is: CHEBI:32551
initial concentration: 1.0
boundary condition: false
has only substance units: false
is: SBO:0000247
name: Holocarboxylase (biotin covalent bound to Lys residue of apoC)
is: HMDB00182
notes: FORMULA: C16H27N4O3SX CHARGE: 0

http://identifiers.org/biomodels.db/MODEL1310110045#_85447379_93b0_469f_83e3_f1191eccac8d
initial concentration: NaN
is: B4DDW0
boundary condition: true
constant: false
name: RDH11
has only substance units: false
type: Species
is encoded by: hsa:51109
is: SBO:0000252
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110045#_0d4c4978_0332_46d1_a2f6_b8fceac7adc8
constant: false
has only substance units: false
name: PCBD1
is: SBO:0000252
type: Species
initial amount: NaN
is: P61457
boundary condition: true
is encoded by: hsa:5092
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110045#_c3612aa2_8c81_4d2d_901d_3e92b2162d54
type: Species
is: SBO:0000252
initial amount: NaN
constant: false
boundary condition: true
is encoded by: hsa:2819
initial concentration: NaN
is: F8W1L5
name: GPD1
has only substance units: false

metaR EX vitd3 LPAREN e RPAREN
kinetic law: MODEL1310110045#
reactant: MODEL1310110045#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for calctriol
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110045#_04996541_a110_4db9_9794_afeabe9768f9
initial amount: NaN
is encoded by: hsa:760
name: CA2
type: Species
constant: false
initial concentration: NaN
is: P00918
has only substance units: false
is: SBO:0000252
boundary condition: true

metaR r2377
kinetic law: MODEL1310110045#
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
product: MODEL1310110045#
is described by: ECO:0000000
fast: false
type: Reaction
reversible: true
reactant: MODEL1310110045#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:16919238,PMID:17173541,PMID:18406340,PMID:8132483 NOTES:
is: SBO:0000185

metaM accoa c
initial amount: NaN
boundary condition: false
is: HMDB01206
constant: false
is: SBO:0000247
is: C00024
notes: FORMULA: C23H34N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00033 EHMN_ABBREVIATION: C00024
initial concentration: 1.0
type: Species
name: Acetyl-CoA
has only substance units: false
is: CHEBI:57288

http://identifiers.org/biomodels.db/MODEL1310110045#_91a81c03_707a_4022_8ba5_8019e0f86761
constant: false
type: Species
boundary condition: true
initial amount: NaN
is: SBO:0000252
is encoded by: hsa:5137
has only substance units: false
initial concentration: NaN
is: Q8NB10
name: PDE1C

metaR NDP10ex
name: nucleoside-diphosphatase (IDP), extracellular
reactant: MODEL1310110045#
type: Reaction
reversible: false
is: SBO:0000176
notes: GENE_ASSOCIATION: (124583.1) SUBSYSTEM: Nucleotide interconversion EC Number: 3.6.1.6 Confidence Level: 4 AUTHORS: PMID:12234496,PMID:12600208 NOTES:IT
fast: false
product: MODEL1310110045#
is version of: http://identifiers.org/ec-code/3.6.1.6
is described by: ECO:0000269
modifier: MODEL1310110045#
kinetic law: MODEL1310110045#

http://identifiers.org/biomodels.db/MODEL1310110045#_ed127f5b_af47_4bb0_844d_0874924ad3f2
is: SBO:0000252
is encoded by: hsa:AA021081
boundary condition: true
constant: false
name: _AA021081_1_r
has only substance units: false
initial amount: NaN
initial concentration: NaN
type: Species

metaR ACACt2
fast: false
type: Reaction
kinetic law: MODEL1310110045#
product: MODEL1310110045#
notes: GENE_ASSOCIATION: (6566.1) or (9194.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10510291,PMID:11101640,PMID:12739169,PMID:7835905,PMID:8476015,PMID:9425115,PMID:9508842,PMID:9649795,PMID:9786900,PMID:9824713 NOTES:originally named AACTP NCD
is: SBO:0000185
name: acetoacetate transport via proton symport
is described by: ECO:0000269
reactant: MODEL1310110045#
modifier: MODEL1310110045#
reversible: true

metaM tag hs c
is: CHEBI:17855
has only substance units: false
notes: FORMULA: C3H5FULLRCO2FULLR2CO2FULLR3CO2 CHARGE: 0
initial amount: NaN
initial concentration: 1.0
type: Species
name: triglyceride
is: SBO:0000247
boundary condition: false
constant: false

metaR r2376
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
reactant: MODEL1310110045#
is described by: ECO:0000000
is: SBO:0000185
type: Reaction
kinetic law: MODEL1310110045#
reversible: true
product: MODEL1310110045#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:16919238,PMID:17173541,PMID:18406340,PMID:8132483 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110045#_366eb970_1a10_4293_b324_fbec1f17b27a
has only substance units: false
is: O75715
constant: false
boundary condition: true
name: GPX5
is: SBO:0000252
is encoded by: hsa:2880
type: Species
initial amount: NaN
initial concentration: NaN

metaM HC02203 c
type: Species
is: CHEBI:27820
initial amount: NaN
name: prostaglandin-a2
initial concentration: 1.0
notes: FORMULA: C20H29O4 CHARGE: -1 INCHI: InChI=1S/C20H30O4/c1-2-3-6-9-17(21)14-12-16-13-15-19(22)18(16)10-7-4-5-8-11-20(23)24/h4,7,12-18,21H,2-3,5-6,8-11H2,1H3,(H,23,24)/b7-4-,14-12+/t16-,17-,18+/m0/s1 EHMN_ABBREVIATION: C05953
is: SBO:0000247
has only substance units: false
boundary condition: false
constant: false

metaR FAOXC16BRx
kinetic law: MODEL1310110045#
product: MODEL1310110045#
reactant: MODEL1310110045#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid activation(C16br)x
type: Reaction

metaR EX xyl D LPAREN e RPAREN
kinetic law: MODEL1310110045#
reactant: MODEL1310110045#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: D-Xylose exchange
type: Reaction

metaR RE1525M
kinetic law: MODEL1310110045#
is: SBO:0000176
product: MODEL1310110045#
notes: GENE_ASSOCIATION: (3295.1) or (1962.1) or (3033.1) or (3028.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.1.1.35 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:7775433 NOTES:
type: Reaction
is version of: http://identifiers.org/ec-code/1.1.1.35
name: RE1525
reactant: MODEL1310110045#
modifier: MODEL1310110045#
reversible: true
fast: false
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/4.2.1.107

metaR RE0828E
reversible: false
notes: GENE_ASSOCIATION: (26.1) SUBSYSTEM: Urea cycle EC Number: 1.4.3.6 Confidence Level: 0 AUTHORS: PMID:10047787,PMID:7040832 NOTES:
is described by: ECO:0000000
reactant: MODEL1310110045#
modifier: MODEL1310110045#
product: MODEL1310110045#
is version of: http://identifiers.org/ec-code/1.4.3.22
type: Reaction
kinetic law: MODEL1310110045#
fast: false
is: SBO:0000176
name: RE0828

http://identifiers.org/biomodels.db/MODEL1310110045#_9312a570_fe5e_4d93_a6d6_a64e648b1273
constant: false
is: SBO:0000252
type: Species
initial amount: NaN
has only substance units: false
name: PPCS
is: Q9HAB8
boundary condition: true
is encoded by: hsa:79717
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110045#_6c5197a1_efff_4e3d_af5d_5372ae686446
is encoded by: hsa:4124
type: Species
is: Q16706
is: SBO:0000252
has only substance units: false
boundary condition: true
initial concentration: NaN
constant: false
initial amount: NaN
name: MAN2A1

http://identifiers.org/biomodels.db/MODEL1310110045#_c0e6bde4_0f76_4eea_9d97_afa9c647a1fa
is: Q8N3T1
is encoded by: hsa:117248
is: SBO:0000252
initial amount: NaN
constant: false
name: GALNTL2
initial concentration: NaN
has only substance units: false
boundary condition: true
type: Species

metaR TYRt
notes: GENE_ASSOCIATION: (117247.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:11827462 NOTES:
fast: false
reversible: true
modifier: MODEL1310110045#
is described by: ECO:0000269
reactant: MODEL1310110045#
product: MODEL1310110045#
type: Reaction
is: SBO:0000185
kinetic law: MODEL1310110045#
name: L-tyrosine transport

http://identifiers.org/biomodels.db/MODEL1310110045#_0336f408_8d4c_442d_9866_67b62715865e
is: SBO:0000252
constant: false
is encoded by: hsa:9377
name: COX5A
boundary condition: true
is: P20674
initial concentration: NaN
type: Species
initial amount: NaN
has only substance units: false

metaR ACGALK
notes: GENE_ASSOCIATION: SUBSYSTEM: Aminosugar metabolism EC Number: Confidence Level: 2 AUTHORS: NOTES:NCD
is described by: ECO:0000000
fast: false
is: SBO:0000176
kinetic law: MODEL1310110045#
reactant: MODEL1310110045#
type: Reaction
product: MODEL1310110045#
reversible: false
name: N-acetylgalactosamine kinase

http://identifiers.org/biomodels.db/MODEL1310110045#_506167ff_8ad7_417c_8fc6_a4804ae28883
type: Species
is encoded by: hsa:4967
boundary condition: true
has only substance units: false
is: SBO:0000252
name: OGDH
initial concentration: NaN
is: Q02218
initial amount: NaN
constant: false

metaR PI45P4P
reversible: false
reactant: MODEL1310110045#
fast: false
type: Reaction
is: SBO:0000176
name: phosphatidylinositol-4,5-bisphosphate 4-phosphatase
kinetic law: MODEL1310110045#
notes: GENE_ASSOCIATION: SUBSYSTEM: Inositol phosphate metabolism EC Number: Confidence Level: 1 AUTHORS: PMID:10358929 NOTES:NCD
is described by: ECO:0000000
product: MODEL1310110045#

http://identifiers.org/biomodels.db/MODEL1310110045#_3df8c1bc_94c9_4d6b_9871_30a8b5a1940c
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:3030
is: E9KL44
constant: false
boundary condition: true
initial concentration: NaN
name: HADHA
has only substance units: false
type: Species

metaR GTHPm
modifier: MODEL1310110045#
kinetic law: MODEL1310110045#
product: MODEL1310110045#
notes: GENE_ASSOCIATION: (10935.1) or (10935.2) or (2879.1) SUBSYSTEM: Glutathione metabolism EC Number: 1.11.1.9 Confidence Level: 4 AUTHORS: PMID:12427732 NOTES:TV (8-15-2003)
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.11.1.12
is version of: http://identifiers.org/ec-code/1.11.1.15
reactant: MODEL1310110045#
type: Reaction
reversible: true
name: glutathione peroxidase, mitochondria
fast: false
is described by: ECO:0000269

metaR RE0383C
reactant: MODEL1310110045#
is version of: http://identifiers.org/ec-code/1.1.1.2
reversible: true
name: RE0383
is described by: ECO:0000000
modifier: MODEL1310110045#
notes: GENE_ASSOCIATION: (10327.1) SUBSYSTEM: Miscellaneous EC Number: 1.1.1.2 Confidence Level: 0 AUTHORS: PMID:1748675 NOTES:
type: Reaction
fast: false
is: SBO:0000176
product: MODEL1310110045#
kinetic law: MODEL1310110045#

http://identifiers.org/biomodels.db/MODEL1310110045#_7f6d9c18_dbe0_4851_80ae_cc9325d5e586
boundary condition: true
name: GSTZ1
initial concentration: NaN
has only substance units: false
is encoded by: hsa:2954
type: Species
is: SBO:0000252
constant: false
initial amount: NaN

metaM cbasp e
notes: FORMULA: C5H6N2O5 CHARGE: -2
initial amount: NaN
initial concentration: 1.0
has only substance units: false
name: N-Carbamoyl-L-aspartate
is: HMDB00828
boundary condition: false
constant: false
is: C00438
is: CHEBI:32814
is: SBO:0000247
type: Species

metaM ksi g
constant: false
initial concentration: 1.0
boundary condition: false
has only substance units: false
is: HMDB01644
initial amount: NaN
is: SBO:0000247
is: CHEBI:17140
type: Species
name: keratan sulfate I
notes: FORMULA: C247H393N17O213S12X CHARGE: -13

http://identifiers.org/biomodels.db/MODEL1310110045#_4d24d2e5_b4d1_44ab_a458_440e16d8e8dd
type: Species
constant: false
is: Q15661
name: TPSAB1
is: SBO:0000252
initial amount: NaN
boundary condition: true
is encoded by: hsa:7177
initial concentration: NaN
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110045#_8ee83a87_e53b_4b0c_b182_3c202e1bc34b
has only substance units: false
initial concentration: NaN
boundary condition: true
is: SBO:0000252
is: P33897
initial amount: NaN
name: ABCD1
type: Species
is encoded by: hsa:215
constant: false

metaR r0055
reversible: true
reactant: MODEL1310110045#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.4.2.8
product: MODEL1310110045#
modifier: MODEL1310110045#
type: Reaction
is version of: http://identifiers.org/ec-code/2.4.2.7
kinetic law: MODEL1310110045#
name: 2-Oxopropanal:NADP+ oxidoreductase Pyruvate metabolism EC:1.2.1.49
is described by: ECO:0000000
fast: false
notes: GENE_ASSOCIATION: (353.1) or (3251.1) SUBSYSTEM: Pyruvate metabolism EC Number: 1.2.1.49 Confidence Level: 0 AUTHORS: PMID:20958,PMID:4383524,PMID:4391087,PMID:6014,PMID:7107625,PMID:7107626,PMID:7144586,PMID:7763257,PMID:7993370 NOTES:IT added 2 protons (are there really 2 protons produced?)

metaR EX acac LPAREN e RPAREN
kinetic law: MODEL1310110045#
reactant: MODEL1310110045#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Acetoacetate exchange
type: Reaction

metaR r1598
product: MODEL1310110045#
kinetic law: MODEL1310110045#
reversible: true
is: SBO:0000185
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reactant: MODEL1310110045#
type: Reaction
is described by: ECO:0000000
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1

http://identifiers.org/biomodels.db/MODEL1310110045#_c0d59f72_887a_4f58_b5e2_e8cf5c3fee42
boundary condition: true
is encoded by: hsa:54576
is: Q5DSZ6
initial concentration: NaN
initial amount: NaN
has only substance units: false
is: SBO:0000252
constant: false
type: Species
name: UGT1A8

metaM cdp c
has only substance units: false
constant: false
name: CDP
is: SBO:0000247
boundary condition: false
is: C00112
initial amount: NaN
initial concentration: 1.0
notes: FORMULA: C9H12N3O11P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00110 EHMN_ABBREVIATION: C00112
is: CHEBI:58069
is: HMDB01546
type: Species

metaM HC01610 e
is: SBO:0000247
initial amount: NaN
has only substance units: false
name: CoproporphyrinogenI
initial concentration: 1.0
is: CHEBI:28607
type: Species
constant: false
boundary condition: false
notes: FORMULA: C36H40N4O8 CHARGE: -4 INCHI: InChI=1S/C36H44N4O8/c1-17-21(5-9-33(41)42)29-14-26-19(3)23(7-11-35(45)46)31(39-26)16-28-20(4)24(8-12-36(47)48)32(40-28)15-27-18(2)22(6-10-34(43)44)30(38-27)13-25(17)37-29/h37-40H,5-16H2,1-4H3,(H,41,42)(H,43,44)(H,45,46)(H,47,48) EHMN_ABBREVIATION: C05768

metaR G3PD2m
is version of: http://identifiers.org/ec-code/1.1.5.3
reactant: MODEL1310110045#
notes: GENE_ASSOCIATION: (2820.1) SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: 1.1.99.5 Confidence Level: 2 AUTHORS: PMID:11385633,PMID:8549872 NOTES:replaces old version which contains redundant metabolite (gly3p) NCD split compartmentation NJ
is described by: ECO:0000304
kinetic law: MODEL1310110045#
product: MODEL1310110045#
fast: false
type: Reaction
reversible: false
name: glycerol-3-phosphate dehydrogenase (FAD), mitochondrial
modifier: MODEL1310110045#
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110045#_70ad8d32_0d88_4f2d_8572_2f43e02b4da3
has only substance units: false
is encoded by: hsa:374907
constant: false
type: Species
initial concentration: NaN
name: B3GNT8
initial amount: NaN
boundary condition: true
is: SBO:0000252

metaR C226CPT1
notes: GENE_ASSOCIATION: (126129.1) or (1375.3) or (1374.1) or (1375.2) or (1375.1) or (1375.4) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.21 Confidence Level: 4 AUTHORS: PMID:1988962 NOTES:TDV
reactant: MODEL1310110045#
modifier: MODEL1310110045#
is described by: ECO:0000000
kinetic law: MODEL1310110045#
product: MODEL1310110045#
is version of: http://identifiers.org/ec-code/2.3.1.21
type: Reaction
fast: false
name: carnitine C22:6 transferase
is: SBO:0000176
reversible: false

metaR DADA
reactant: MODEL1310110045#
modifier: MODEL1310110045#
type: Reaction
kinetic law: MODEL1310110045#
product: MODEL1310110045#
reversible: false
is: SBO:0000176
name: Deoxyadenosine deaminase
is described by: ECO:0000269
fast: false
notes: GENE_ASSOCIATION: (100.1) SUBSYSTEM: Nucleotide interconversion EC Number: 3.5.4.4 Confidence Level: 4 AUTHORS: PMID:12381379,PMID:15016824 NOTES:JLR
is version of: http://identifiers.org/ec-code/3.5.4.4

metaR GLYPHEPEPT1tc
kinetic law: MODEL1310110045#
product: MODEL1310110045#
reactant: MODEL1310110045#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of Glycylphenylalanine by the apical PEPT1 amino acid transporters across the brush border cells of the enterocytes of the intestine and renal cells
type: Reaction

metaM 3hexdtetcoa m
constant: false
name: 3,7,10,13-hexadecatetraenoylcoa
type: Species
has only substance units: false
is: HMDB02288
initial amount: NaN
boundary condition: false
notes: FORMULA: C37H54N7O17P3S CHARGE: -4
is: SBO:0000247
initial concentration: 1.0

metaR GMPtg
reactant: MODEL1310110045#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, golgi apparatus EC Number: 6.3.5.2 Confidence Level: 1 AUTHORS: PMID:7706277 NOTES:
name: GMP transport (Golgi)
is described by: ECO:0000269
fast: false
is: SBO:0000185
type: Reaction
product: MODEL1310110045#
kinetic law: MODEL1310110045#
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110045#_a77099f3_fe35_42a0_950f_f97c65b8c67c
boundary condition: true
type: Species
name: DPM1
initial concentration: NaN
has only substance units: false
is: SBO:0000252
constant: false
initial amount: NaN
is: O60762
is encoded by: hsa:8813

metaR DGK1
is described by: ECO:0000269
modifier: MODEL1310110045#
fast: false
reversible: true
is: SBO:0000176
kinetic law: MODEL1310110045#
notes: GENE_ASSOCIATION: (2987.1) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: NOTES:
product: MODEL1310110045#
name: deoxyguanylate kinase (dGMP:ATP)
reactant: MODEL1310110045#
is version of: http://identifiers.org/ec-code/2.7.4.8
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110045#_07279ff5_3af9_4aa1_8e71_eb7f231061e0
is: Q3I5F7
constant: false
initial concentration: NaN
is: SBO:0000252
has only substance units: false
name: ACOT6
type: Species
is encoded by: hsa:641372
boundary condition: true
initial amount: NaN

metaM nadh r
type: Species
is: CHEBI:57945
boundary condition: false
constant: false
name: NADH(2-)
notes: FORMULA: C21H27N7O14P2 CHARGE: -2 INCHI: InChI=1S/C21H29N7O14P2/c22-17-12-19(25-7-24-17)28(8-26-12)21-16(32)14(30)11(41-21)6-39-44(36,37)42-43(34,35)38-5-10-13(29)15(31)20(40-10)27-3-1-2-9(4-27)18(23)33/h1,3-4,7-8,10-11,13-16,20-21,29-32H,2,5-6H2,(H2,23,33)(H,34,35)(H,36,37)(H2,22,24,25)/p-2/t10-,11-,13-,14-,15-,16-,20-,21-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00014 EHMN_ABBREVIATION: C00004
is: SBO:0000247
has only substance units: false
initial concentration: 1.0
is: HMDB01487
initial amount: NaN

metaR RE0935E
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (276.1) or (277.1) or (278.1) or (279.1) or (276.1) or (277.1) or (278.1) or (279.1) or (280.1) or (84569.1) SUBSYSTEM: Starch and sucrose metabolism EC Number: 3.2.1.1 Confidence Level: 0 AUTHORS: PMID:385176,PMID:8528071,PMID:890964 NOTES:
reactant: MODEL1310110045#
fast: false
is version of: http://identifiers.org/ec-code/3.2.1.1
kinetic law: MODEL1310110045#
modifier: MODEL1310110045#
product: MODEL1310110045#
name: RE0935
is version of: http://identifiers.org/ec-code/3.2.1.17
reversible: true
type: Reaction
is: SBO:0000176

metaR r1599
kinetic law: MODEL1310110045#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
product: MODEL1310110045#
reactant: MODEL1310110045#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
type: Reaction
fast: false
is: SBO:0000185
is described by: ECO:0000000
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110045#_2af11688_c7d4_4648_b948_77ed0597e72e
has only substance units: false
is: SBO:0000252
is: Q96Q11
type: Species
initial concentration: NaN
constant: false
initial amount: NaN
boundary condition: true
name: TRNT1
is encoded by: hsa:51095

metaM ksi e
has only substance units: false
initial concentration: 1.0
boundary condition: false
is: CHEBI:17268
constant: false
initial amount: NaN
is: SBO:0000247
name: keratan sulfate I
type: Species
is: HMDB00211
notes: FORMULA: C247H393N17O213S12X CHARGE: -13

metaM mag hs e
name: monoacylglycerol 2
constant: false
is: HMDB03073
notes: FORMULA: C3H7O2FULLR2CO2 CHARGE: 0
is: CHEBI:32391
initial concentration: 1.0
type: Species
boundary condition: false
has only substance units: false
is: SBO:0000247
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110045#_c7ddd57c_bce4_4afc_9f39_d73507fea918
boundary condition: true
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:5142
constant: false
has only substance units: false
initial amount: NaN
type: Species
name: PDE4B
is: Q5TEK5

metaM docohepcoa m
is: SBO:0000247
initial amount: NaN
notes: FORMULA: C43H60N7O17P3S CHARGE: -4
initial concentration: 1.0
has only substance units: false
type: Species
name: 2,4,7,10,13,16,19-docosaheptenoylcoa
is: HMDB06294
boundary condition: false
constant: false

metaM ctp e
constant: false
name: CTP(4-)
is: HMDB00082
notes: FORMULA: C9H12N3O14P3 CHARGE: -4 INCHI: InChI=1S/C9H16N3O14P3/c10-5-1-2-12(9(15)11-5)8-7(14)6(13)4(24-8)3-23-28(19,20)26-29(21,22)25-27(16,17)18/h1-2,4,6-8,13-14H,3H2,(H,19,20)(H,21,22)(H2,10,11,15)(H2,16,17,18)/p-4/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00066 EHMN_ABBREVIATION: C00063
is: CHEBI:37563
initial amount: NaN
is: SBO:0000247
type: Species
has only substance units: false
initial concentration: 1.0
boundary condition: false

metaR RE3566C
name: RE3566
type: Reaction
product: MODEL1310110045#
reactant: MODEL1310110045#
kinetic law: MODEL1310110045#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Eicosanoid metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:234423 NOTES:
fast: false
reversible: true
is: SBO:0000176

metaM HC01842 c
initial concentration: 1.0
type: Species
has only substance units: false
constant: false
is: SBO:0000247
initial amount: NaN
boundary condition: false
name: Phosphodimethylethanolamine
is: CHEBI:31997
notes: FORMULA: C4H10NO4P CHARGE: -2 INCHI: InChI=1S/C4H12NO4P/c1-5(2)3-4-9-10(6,7)8/h3-4H2,1-2H3,(H2,6,7,8)

metaR r1596
reversible: true
kinetic law: MODEL1310110045#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
fast: false
is: SBO:0000185
reactant: MODEL1310110045#
type: Reaction
is described by: ECO:0000000
product: MODEL1310110045#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1

metaM icit c
initial concentration: 1.0
is: HMDB00193
boundary condition: false
is: CHEBI:16087
constant: false
is: SBO:0000247
type: Species
notes: FORMULA: C6H5O7 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00266 EHMN_ABBREVIATION: C00311
initial amount: NaN
name: Isocitrate
has only substance units: false
is: C00311

metaM ksi deg23 l
has only substance units: false
is: CHEBI:12936
constant: false
name: keratan sulfate I, degradation product 23
initial amount: NaN
initial concentration: 1.0
type: Species
is: HMDB00143
is: SBO:0000247
notes: FORMULA: C124H201N8O106S5 CHARGE: -5
boundary condition: false

metaR r0791
name: trans-Hex-2-enoyl-CoA reductase Fatty acid elongation in mitochondria EC:1.3.1.38
fast: false
notes: GENE_ASSOCIATION: (1962.1) or (3033.1) or (3028.1) or (3295.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.1.38 Confidence Level: 0 AUTHORS: PMID:12654921 NOTES:
reactant: MODEL1310110045#
is: SBO:0000176
is described by: ECO:0000000
reversible: true
is version of: http://identifiers.org/ec-code/1.1.1.35
kinetic law: MODEL1310110045#
type: Reaction
modifier: MODEL1310110045#
product: MODEL1310110045#
is version of: http://identifiers.org/ec-code/4.2.1.107

metaR TXA2tr
fast: false
product: MODEL1310110045#
name: thromboxane A2 intracellular transport
is described by: ECO:0000000
reversible: true
reactant: MODEL1310110045#
type: Reaction
is: SBO:0000185
kinetic law: MODEL1310110045#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: NOTES:unknown mechanism for transport - known to be secreted from cells - unknown mechanism or pathway, TXA2tr -> TXA2te to get to EC space NJ

http://identifiers.org/biomodels.db/MODEL1310110045#_2a7c96df_86e9_4161_b1cf_d054e17f2b24
type: Species
initial concentration: NaN
initial amount: NaN
is: SBO:0000252
has only substance units: false
boundary condition: true
name: _AW299740_1_m
constant: false
is encoded by: hsa:AW299740

metaM crvnc e
has only substance units: false
constant: false
is: CHEBI:36005
initial amount: NaN
notes: FORMULA: C22H31O2 CHARGE: -1
name: cervonic acid, C22:6 n-3
is: SBO:0000247
is: HMDB02183
boundary condition: false
initial concentration: 1.0
type: Species

http://identifiers.org/biomodels.db/MODEL1310110045#_e812a539_33d2_42a5_8286_8782ef9d53cc
has only substance units: false
is: SBO:0000252
initial concentration: NaN
constant: false
is: Q9Y5L3
type: Species
initial amount: NaN
is encoded by: hsa:954
boundary condition: true
name: ENTPD2

http://identifiers.org/biomodels.db/MODEL1310110045#_9d459e68_c3b3_498e_bd8c_768374951d00
type: Species
constant: false
name: INPP5E
initial amount: NaN
is encoded by: hsa:56623
is: Q9NRR6
boundary condition: true
is: SBO:0000252
has only substance units: false
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110045#_653a577d_bd4d_4989_bfa4_aede5df827a6
name: SLC27A5
constant: false
is encoded by: hsa:10998
has only substance units: false
boundary condition: true
is: Q9Y2P5
initial amount: NaN
type: Species
initial concentration: NaN
is: SBO:0000252

metaR r1853
is: SBO:0000185
name: Y+LAT2 Utilized transport
reversible: false
product: MODEL1310110045#
modifier: MODEL1310110045#
kinetic law: MODEL1310110045#
is described by: ECO:0000000
type: Reaction
reactant: MODEL1310110045#
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
fast: false

metaM cdp e
has only substance units: false
initial amount: NaN
is: SBO:0000247
notes: FORMULA: C9H12N3O11P2 CHARGE: -3 INCHI: InChI=1S/C9H15N3O11P2/c10-5-1-2-12(9(15)11-5)8-7(14)6(13)4(22-8)3-21-25(19,20)23-24(16,17)18/h1-2,4,6-8,13-14H,3H2,(H,19,20)(H2,10,11,15)(H2,16,17,18)/p-3/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00110 EHMN_ABBREVIATION: C00112
is: CHEBI:58069
type: Species
boundary condition: false
is: HMDB01546
name: CDP(3-)
initial concentration: 1.0
constant: false

metaR r1597
fast: false
kinetic law: MODEL1310110045#
is: SBO:0000185
reactant: MODEL1310110045#
reversible: true
product: MODEL1310110045#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
type: Reaction
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110045#_6d6154ba_4c0d_4a95_8af1_7967959f4282
is: SBO:0000252
name: SCD
is encoded by: hsa:6319
boundary condition: true
initial concentration: NaN
type: Species
constant: false
initial amount: NaN
is: O00767
has only substance units: false

metaR EX tyr L LPAREN e RPAREN
kinetic law: MODEL1310110045#
reactant: MODEL1310110045#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: L-Tyrosine exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110045#_0fb1a8e9_c9ec_45f6_b845_0ec9e7eea942
has only substance units: false
type: Species
name: DPM2
initial amount: NaN
boundary condition: true
initial concentration: NaN
is: SBO:0000252
constant: false
is: O94777
is encoded by: hsa:8818

metaR CYTDtm
type: Reaction
product: MODEL1310110045#
reversible: true
fast: false
is described by: ECO:0000269
kinetic law: MODEL1310110045#
is: SBO:0000185
notes: GENE_ASSOCIATION: (2030.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:10722669,PMID:12838422,PMID:14607828 NOTES:IT
modifier: MODEL1310110045#
reactant: MODEL1310110045#
name: cytidine facilated transport in mitochondria

metaM ctp c
type: Species
is: C00063
notes: FORMULA: C9H12N3O14P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00066 EHMN_ABBREVIATION: C00063
constant: false
is: HMDB00082
is: SBO:0000247
name: CTP
is: CHEBI:37563
initial concentration: 1.0
boundary condition: false
has only substance units: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110045#_ca69f8fe_58d3_4c57_8a83_1b44489fbef5
is: SBO:0000252
constant: false
type: Species
is encoded by: hsa:1956
boundary condition: true
is: P00533
has only substance units: false
name: EGFR
initial concentration: NaN
initial amount: NaN

metaR r0051
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (AI769281.1) or (30833.1) or (93034.1) or (22978.1) or (51251.1) or (4907.1) or (56953.1) or (57786.1) or (57665.1) SUBSYSTEM: Purine catabolism EC Number: 2.4.2.7 Confidence Level: 0 AUTHORS: PMID:6778226,PMID:692402 NOTES:
reactant: MODEL1310110045#
is: SBO:0000176
fast: false
kinetic law: MODEL1310110045#
reversible: true
product: MODEL1310110045#
type: Reaction
name: AMP:pyrophosphate phosphoribosyltransferase Purine metabolism EC:2.4.2.7
is version of: http://identifiers.org/ec-code/3.1.3.5
modifier: MODEL1310110045#

http://identifiers.org/biomodels.db/MODEL1310110045#_d24f1b06_b0a9_4a0a_b390_b9c53d337b7d
is encoded by: hsa:4645
is: SBO:0000252
initial amount: NaN
constant: false
boundary condition: true
is: Q9H6Y6
has only substance units: false
type: Species
initial concentration: NaN
name: MYO5B

metaR r1594
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
fast: false
kinetic law: MODEL1310110045#
product: MODEL1310110045#
reversible: true
is: SBO:0000185
reactant: MODEL1310110045#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
type: Reaction
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110045#_4c9bf10a_982c_42ce_aac3_41e2160b8202
type: Species
boundary condition: true
initial amount: NaN
name: CHAT
is: SBO:0000252
is: Q6LEN6
has only substance units: false
initial concentration: NaN
is encoded by: hsa:1103
constant: false

http://identifiers.org/biomodels.db/MODEL1310110045#_aa6700fd_2273_4ddb_931f_699a2071575c
type: Species
is: Q674R7
has only substance units: false
is encoded by: hsa:285973
name: ATG9B
is: SBO:0000252
initial amount: NaN
initial concentration: NaN
constant: false
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110045#_5c65190b_9ab5_4da8_8f2c_883449bcb203
initial amount: NaN
is: SBO:0000252
name: DPM3
initial concentration: NaN
is: Q9P2X0
boundary condition: true
type: Species
has only substance units: false
is encoded by: hsa:54344
constant: false

metaM dhdascb c
constant: false
name: dehydroascorbide(1-)
notes: FORMULA: C6H6O6 CHARGE: 0 INCHI: InChI=1S/C6H5O6/c7-1-2(8)5-3(9)4(10)6(11)12-5/h2,7-8H,1H2/q-1 EHMN_ABBREVIATION: C00425
is: SBO:0000247
type: Species
has only substance units: false
is: CHEBI:58070
boundary condition: false
is: HMDB01264
initial concentration: 1.0
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110045#_7e3e81e5_36de_4a21_bdfd_3a014b230114
is encoded by: hsa:2643
is: SBO:0000252
is: Q8IZH9
initial concentration: NaN
constant: false
initial amount: NaN
boundary condition: true
name: GCH1
type: Species
has only substance units: false

metaM crvnc c
type: Species
has only substance units: false
notes: FORMULA: C22H31O2 CHARGE: -1
is: CHEBI:36005
name: cervonic acid, C22:6 n-3
constant: false
initial amount: NaN
is: HMDB02183
boundary condition: false
initial concentration: 1.0
is: SBO:0000247

metaR EX lnlc LPAREN e RPAREN
kinetic law: MODEL1310110045#
reactant: MODEL1310110045#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: linoleic acid (all cis C18:2) exchange
type: Reaction

metaR PNTK
notes: GENE_ASSOCIATION: (79646.1) or (80025.2) or (53354.1) or (53354.3) or (80025.1) or (53354.2) or (80025.3) or (80025.4) or (55229.1) SUBSYSTEM: CoA synthesis EC Number: Confidence Level: 4 AUTHORS: NOTES:
product: MODEL1310110045#
is version of: http://identifiers.org/ec-code/2.7.1.33
reactant: MODEL1310110045#
kinetic law: MODEL1310110045#
modifier: MODEL1310110045#
is described by: ECO:0000269
is: SBO:0000176
type: Reaction
fast: false
reversible: false
name: pantothenate kinase

http://identifiers.org/biomodels.db/MODEL1310110045#_11438527_64e1_475e_86b3_a24a988ebcc7
boundary condition: true
has only substance units: false
is encoded by: hsa:NOS2A
type: Species
initial concentration: NaN
name: _NOS2A_1_e
is: SBO:0000252
constant: false
initial amount: NaN

metaR r1595
type: Reaction
is described by: ECO:0000000
kinetic law: MODEL1310110045#
fast: false
is: SBO:0000185
reactant: MODEL1310110045#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reversible: true
product: MODEL1310110045#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:

metaR TXASr
is described by: ECO:0000134
notes: GENE_ASSOCIATION: (6916.1) SUBSYSTEM: Eicosanoid metabolism EC Number: 5.3.99.5 Confidence Level: 0 AUTHORS: PMID:10903770,PMID:2491846,PMID:7811713 NOTES:NJ
modifier: MODEL1310110045#
product: MODEL1310110045#
name: Thromboxane-A synthase
is: SBO:0000176
is version of: http://identifiers.org/ec-code/5.3.99.5
reactant: MODEL1310110045#
fast: false
kinetic law: MODEL1310110045#
reversible: false
type: Reaction

metaR G14T18g
kinetic law: MODEL1310110045#
reactant: MODEL1310110045#
modifier: MODEL1310110045#
name: beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase, Golgi
is version of: http://identifiers.org/ec-code/2.4.1.38
is: SBO:0000176
fast: false
reversible: false
product: MODEL1310110045#
is version of: http://identifiers.org/ec-code/2.4.1.90
notes: GENE_ASSOCIATION: (8703.1) or (8704.2) or (8704.1) or (2683.1) or (9334.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.38 Confidence Level: 4 AUTHORS: PMID:10747980,PMID:12512857,PMID:1903938,PMID:3094506,PMID:3144273,PMID:9405390,PMID:9435216 NOTES:Keratan sulfate II biosynthesis NCD
is version of: http://identifiers.org/ec-code/2.4.1.22
is described by: ECO:0000000
type: Reaction

metaR AICART
modifier: MODEL1310110045#
notes: GENE_ASSOCIATION: (471.1) SUBSYSTEM: Purine synthesis EC Number: 2.1.2.3 Confidence Level: 4 AUTHORS: PMID:11948179,PMID:14966129,PMID:9378707 NOTES:
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.1.2.3
name: phosphoribosylaminoimidazolecarboxamide formyltransferase
is described by: ECO:0000269
fast: false
type: Reaction
kinetic law: MODEL1310110045#
product: MODEL1310110045#
reversible: true
reactant: MODEL1310110045#

http://identifiers.org/biomodels.db/MODEL1310110045#_4aec0041_6163_43b3_8719_0effb17a4c81
initial concentration: NaN
boundary condition: true
type: Species
constant: false
has only substance units: false
is encoded by: hsa:AA419122
name: _AA419122_1_c
is: SBO:0000252
initial amount: NaN

metaM prpncoa m
name: acryloyl-CoA(4-)
is: CHEBI:57367
initial concentration: 1.0
notes: FORMULA: C24H34N7O17P3S CHARGE: -4 INCHI: InChI=1S/C24H38N7O17P3S/c1-4-15(33)52-8-7-26-14(32)5-6-27-22(36)19(35)24(2,3)10-45-51(42,43)48-50(40,41)44-9-13-18(47-49(37,38)39)17(34)23(46-13)31-12-30-16-20(25)28-11-29-21(16)31/h4,11-13,17-19,23,34-35H,1,5-10H2,2-3H3,(H,26,32)(H,27,36)(H,40,41)(H,42,43)(H2,25,28,29)(H2,37,38,39)/p-4/t13-,17-,18-,19+,23-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00579 EHMN_ABBREVIATION: C00894
initial amount: NaN
boundary condition: false
constant: false
is: HMDB02307
is: SBO:0000247
type: Species
has only substance units: false

metaM glyb c
constant: false
name: glycine betaine
notes: FORMULA: C5H11NO2 CHARGE: 0 INCHI: InChI=1S/C5H11NO2/c1-6(2,3)4-5(7)8/h4H2,1-3H3 HEPATONET_1.0_ABBREVIATION: HC00515 EHMN_ABBREVIATION: C00719
is: SBO:0000247
initial concentration: 1.0
has only substance units: false
initial amount: NaN
boundary condition: false
is: CHEBI:17750
is: HMDB00043
type: Species

metaM CE5125 x
initial amount: NaN
constant: false
type: Species
boundary condition: false
is: CHEBI:12947
name: (2S)-pristanoyl-CoA
initial concentration: 1.0
is: SBO:0000247
notes: FORMULA: C40H68N7O17P3S CHARGE: -4 INCHI: InChI=1/C40H72N7O17P3S/c1-25(2)11-8-12-26(3)13-9-14-27(4)15-10-16-28(5)39(52)68-20-19-42-30(48)17-18-43-37(51)34(50)40(6,7)22-61-67(58,59)64-66(56,57)60-21-29-33(63-65(53,54)55)32(49)38(62-29)47-24-46-31-35(41)44-23-45-36(31)47/h23-29,32-34,38,49-50H,8-22H2,1-7H3,(H,42,48)(H,43,51)(H,56,57)(H,58,59)(H2,41,44,45)(H2,53,54,55)/p-4/t26-,27-,28-,29-,32+,33+,34u,38-/m0/s1 EHMN_ABBREVIATION: CE5125
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110045#_0a7f08bc_36da_4eb7_917f_331000dfd707
initial amount: NaN
boundary condition: true
is: Q16720
is encoded by: hsa:492
initial concentration: NaN
constant: false
is: SBO:0000252
name: ATP2B3
type: Species
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110045#_b87273d5_d7f8_4c3b_96fb_039fdd9a5018
is encoded by: hsa:H17063
initial amount: NaN
type: Species
constant: false
is: SBO:0000252
has only substance units: false
name: _H17063_1_c
initial concentration: NaN
boundary condition: true

metaM retinal c
notes: FORMULA: C20H28O CHARGE: 0 INCHI: InChI=1S/C20H28O/c1-16(8-6-9-17(2)13-15-21)11-12-19-18(3)10-7-14-20(19,4)5/h6,8-9,11-13,15H,7,10,14H2,1-5H3 EHMN_ABBREVIATION: C00376
name: retinal
initial amount: NaN
is: CHEBI:15035
initial concentration: 1.0
boundary condition: false
is: HMDB01358
constant: false
is: SBO:0000247
type: Species
has only substance units: false

metaR 5ADTSTSTERONESte
name: sulfonated testosterone transport
product: MODEL1310110045#
reactant: MODEL1310110045#
reversible: true
fast: false
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 1 AUTHORS: NOTES:unknown mechanism - presumed excretion of sulfonated testosterone NJ
is: SBO:0000185
type: Reaction
kinetic law: MODEL1310110045#

metaM cbasp c
has only substance units: false
boundary condition: false
notes: FORMULA: C5H6N2O5 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00356 EHMN_ABBREVIATION: C00438
is: HMDB00828
initial amount: NaN
name: N-Carbamoyl-L-aspartate
is: C00438
is: SBO:0000247
constant: false
is: CHEBI:32814
initial concentration: 1.0
type: Species

metaM gmp c
initial amount: NaN
boundary condition: false
name: GMP
is: C00144
is: HMDB01397
initial concentration: 1.0
is: SBO:0000247
has only substance units: false
constant: false
type: Species
notes: FORMULA: C10H12N5O8P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00141 EHMN_ABBREVIATION: C00144
is: CHEBI:58115

metaM udp l
is: HMDB00295
type: Species
is: SBO:0000247
name: UDP(3-)
is: CHEBI:58223
initial amount: NaN
has only substance units: false
constant: false
boundary condition: false
initial concentration: 1.0
notes: FORMULA: C9H11N2O12P2 CHARGE: -3 INCHI: InChI=1S/C9H14N2O12P2/c12-5-1-2-11(9(15)10-5)8-7(14)6(13)4(22-8)3-21-25(19,20)23-24(16,17)18/h1-2,4,6-8,13-14H,3H2,(H,19,20)(H,10,12,15)(H2,16,17,18)/p-3/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00025 EHMN_ABBREVIATION: C00015

metaM mmcoa S m
is: CHEBI:57327
constant: false
initial concentration: 1.0
name: (S)-methylmalonyl-CoA(5-)
has only substance units: false
boundary condition: false
is: SBO:0000247
type: Species
notes: FORMULA: C25H35N7O19P3S CHARGE: -5 INCHI: InChI=1S/C25H40N7O19P3S/c1-12(23(37)38)24(39)55-7-6-27-14(33)4-5-28-21(36)18(35)25(2,3)9-48-54(45,46)51-53(43,44)47-8-13-17(50-52(40,41)42)16(34)22(49-13)32-11-31-15-19(26)29-10-30-20(15)32/h10-13,16-18,22,34-35H,4-9H2,1-3H3,(H,27,33)(H,28,36)(H,37,38)(H,43,44)(H,45,46)(H2,26,29,30)(H2,40,41,42)/p-5/t12-,13+,16+,17+,18-,22+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00495
initial amount: NaN
is: HMDB02310

http://identifiers.org/biomodels.db/MODEL1310110045#_eef85a04_23ad_4ba2_9694_9cc1920599a3
is encoded by: hsa:159963
has only substance units: false
constant: false
boundary condition: true
initial concentration: NaN
initial amount: NaN
is: SBO:0000252
name: SLC5A12
type: Species
is: Q1EHB4

metaR r0475
kinetic law: MODEL1310110045#
reversible: true
name: 2-Deoxyadenosine 5-diphosphate:oxidized-thioredoxin 2-oxidoreductase Purine metabolism EC:1.17.4.1
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Nucleotide interconversion EC Number: 1.17.4.1 Confidence Level: 0 AUTHORS: PMID:6121703,PMID:8074691 NOTES:
product: MODEL1310110045#
is described by: ECO:0000000
reactant: MODEL1310110045#
fast: false
is: SBO:0000176

metaR URIK1
reactant: MODEL1310110045#
notes: GENE_ASSOCIATION: (7371.1) or (83549.1) SUBSYSTEM: Pyrimidine synthesis EC Number: 2.7.1.48 Confidence Level: 4 AUTHORS: PMID:11306702,PMID:12199906,PMID:8812458 NOTES:
name: uridine kinase (ATP:Uridine)
kinetic law: MODEL1310110045#
modifier: MODEL1310110045#
fast: false
product: MODEL1310110045#
is version of: http://identifiers.org/ec-code/2.7.1.48
is: SBO:0000176
reversible: false
type: Reaction
is described by: ECO:0000269

http://identifiers.org/biomodels.db/MODEL1310110045#_732601c3_cf52_456d_9afd_979162b5df8c
boundary condition: true
is encoded by: hsa:5167
name: ENPP1
has only substance units: false
constant: false
initial concentration: NaN
type: Species
is: SBO:0000252
initial amount: NaN
is: P22413

metaM 4ppcys c
constant: false
has only substance units: false
is: C04352
name: N-((R)-4-Phosphopantothenoyl)-L-cysteine
is: CHEBI:59458
notes: FORMULA: C12H20N2O9PS CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC01276 EHMN_ABBREVIATION: C04352
type: Species
is: SBO:0000247
initial concentration: 1.0
is: HMDB01117
boundary condition: false
initial amount: NaN

metaM HC00319 c
initial amount: NaN
notes: FORMULA: C3H2O4 CHARGE: -2 INCHI: InChI=1S/C3H4O4/c4-2(5)1-3(6)7/h1H2,(H,4,5)(H,6,7)
initial concentration: 1.0
boundary condition: false
is: CHEBI:30794
is: SBO:0000247
type: Species
name: Malonate
has only substance units: false
constant: false

http://identifiers.org/biomodels.db/MODEL1310110045#_2578b3fe_a529_4d9c_aa65_f83137f1b074
initial amount: NaN
has only substance units: false
is encoded by: hsa:471
name: ATIC
boundary condition: true
initial concentration: NaN
constant: false
is: SBO:0000252
is: P31939
type: Species

http://identifiers.org/biomodels.db/MODEL1310110045#_8103a30d_7f0b_418b_844e_e54a5cdfb694
name: SLC6A9
has only substance units: false
constant: false
is: B7Z3W8
initial amount: NaN
type: Species
is: SBO:0000252
boundary condition: true
initial concentration: NaN
is encoded by: hsa:6536

metaM mn l
name: beta-1,4-mannose-N-acetylglucosamine
is: SBO:0000247
is: HMDB06535
constant: false
type: Species
initial concentration: 1.0
boundary condition: false
initial amount: NaN
has only substance units: false
notes: FORMULA: C14H25NO11 CHARGE: 0 INCHI: InChI=1/C14H25NO11/c1-4(18)15-7-9(20)12(6(3-17)24-13(7)23)26-14-11(22)10(21)8(19)5(2-16)25-14/h5-14,16-17,19-23H,2-3H2,1H3,(H,15,18)/t5-,6-,7-,8-,9-,10+,11+,12-,13-,14-/m1/s1

metaM idp n
is: CHEBI:58280
has only substance units: false
is: HMDB03335
initial concentration: 1.0
name: IDP(3-)
boundary condition: false
type: Species
constant: false
is: SBO:0000247
notes: FORMULA: C10H11N4O11P2 CHARGE: -3 INCHI: InChI=1S/C10H14N4O11P2/c15-6-4(1-23-27(21,22)25-26(18,19)20)24-10(7(6)16)14-3-13-5-8(14)11-2-12-9(5)17/h2-4,6-7,10,15-16H,1H2,(H,21,22)(H,11,12,17)(H2,18,19,20)/p-3/t4-,6-,7-,10-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00104 EHMN_ABBREVIATION: C00104
initial amount: NaN

metaM udp n
has only substance units: false
initial amount: NaN
is: CHEBI:58223
boundary condition: false
is: SBO:0000247
type: Species
constant: false
initial concentration: 1.0
name: UDP(3-)
notes: FORMULA: C9H11N2O12P2 CHARGE: -3 INCHI: InChI=1S/C9H14N2O12P2/c12-5-1-2-11(9(15)10-5)8-7(14)6(13)4(22-8)3-21-25(19,20)23-24(16,17)18/h1-2,4,6-8,13-14H,3H2,(H,19,20)(H,10,12,15)(H2,16,17,18)/p-3/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00025 EHMN_ABBREVIATION: C00015
is: HMDB00295

http://identifiers.org/biomodels.db/MODEL1310110045#_07e91fa8_acd5_4c11_8818_84af939df607
has only substance units: false
is: Q9UN76
constant: false
is encoded by: hsa:11254
is: SBO:0000252
name: SLC6A14
initial concentration: NaN
boundary condition: true
initial amount: NaN
type: Species

http://identifiers.org/biomodels.db/MODEL1310110045#_12d6529f_a1b7_46c0_b5d2_a378a1d29a83
has only substance units: false
is: SBO:0000252
boundary condition: true
is encoded by: hsa:M68895
initial amount: NaN
type: Species
constant: false
name: _M68895_1_c
initial concentration: NaN

metaR EX dcsptn1 LPAREN e RPAREN
kinetic law: MODEL1310110045#
reactant: MODEL1310110045#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: docosa-4,7,10,13,16-pentaenoic acid (n-6) exchange
type: Reaction

metaM dhf m
constant: false
notes: FORMULA: C19H19N7O6 CHARGE: -2 INCHI: InChI=1S/C19H21N7O6/c20-19-25-15-14(17(30)26-19)23-11(8-22-15)7-21-10-3-1-9(2-4-10)16(29)24-12(18(31)32)5-6-13(27)28/h1-4,12,21H,5-8H2,(H,24,29)(H,27,28)(H,31,32)(H4,20,22,25,26,30)/p-2/t12-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00340 EHMN_ABBREVIATION: C00415
initial concentration: 1.0
boundary condition: false
name: dihydrofolate(2-)
type: Species
is: SBO:0000247
is: CHEBI:57451
has only substance units: false
is: HMDB01056
initial amount: NaN

metaR EX ala B LPAREN e RPAREN
kinetic law: MODEL1310110045#
reactant: MODEL1310110045#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: beta-Alanine exchange
type: Reaction

metaR EX CE2838 LPAREN e RPAREN
kinetic law: MODEL1310110045#
reactant: MODEL1310110045#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: maltononaose exchange
type: Reaction

metaR EX taur LPAREN e RPAREN
kinetic law: MODEL1310110045#
reactant: MODEL1310110045#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Taurine exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110045#_e4ef0664_7374_42ba_86b3_5b2b44fe825e
boundary condition: true
initial concentration: NaN
initial amount: NaN
constant: false
is: SBO:0000252
is encoded by: hsa:4729
has only substance units: false
type: Species
is: P19404
name: NDUFV2

metaM accoa x
is: CHEBI:57288
has only substance units: false
is: SBO:0000247
notes: FORMULA: C23H34N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00033 EHMN_ABBREVIATION: C00024
initial amount: NaN
boundary condition: false
type: Species
initial concentration: 1.0
is: C00024
name: Acetyl-CoA
is: HMDB01206
constant: false

metaM nadph r
has only substance units: false
boundary condition: false
initial concentration: 1.0
name: Nicotinamide adenine dinucleotide phosphate - reduced
type: Species
is: SBO:0000247
is: HMDB00221
initial amount: NaN
is: CHEBI:57783
is: C00005
constant: false
notes: FORMULA: C21H26N7O17P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00015 EHMN_ABBREVIATION: C00005

metaM dhf l
boundary condition: false
initial amount: NaN
name: dihydrofolate(2-)
is: CHEBI:57451
constant: false
is: HMDB01056
type: Species
notes: FORMULA: C19H19N7O6 CHARGE: -2 INCHI: InChI=1S/C19H21N7O6/c20-19-25-15-14(17(30)26-19)23-11(8-22-15)7-21-10-3-1-9(2-4-10)16(29)24-12(18(31)32)5-6-13(27)28/h1-4,12,21H,5-8H2,(H,24,29)(H,27,28)(H,31,32)(H4,20,22,25,26,30)/p-2/t12-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00340 EHMN_ABBREVIATION: C00415
is: SBO:0000247
initial concentration: 1.0
has only substance units: false

metaR r0474
reactant: MODEL1310110045#
type: Reaction
kinetic law: MODEL1310110045#
is described by: ECO:0000000
product: MODEL1310110045#
name: 2-Deoxyadenosine 5-diphosphate:oxidized-thioredoxin 2-oxidoreductase Purine metabolism EC:1.17.4.1
is: SBO:0000176
reversible: true
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Nucleotide interconversion EC Number: 1.17.4.1 Confidence Level: 0 AUTHORS: PMID:6121703,PMID:8074691 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110045#_e3e6c8b2_881c_4176_8f44_a9f33b714679
boundary condition: true
is encoded by: hsa:206358
initial concentration: NaN
is: Q1LZ56
is: SBO:0000252
has only substance units: false
constant: false
initial amount: NaN
type: Species
name: SLC36A1

metaR EX leuktrA4 LPAREN e RPAREN
kinetic law: MODEL1310110045#
reactant: MODEL1310110045#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: leukotriene A4 exchange
type: Reaction

metaM nadph m
is: HMDB00221
initial amount: NaN
constant: false
is: C00005
notes: FORMULA: C21H26N7O17P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00015 EHMN_ABBREVIATION: C00005
is: CHEBI:57783
is: SBO:0000247
boundary condition: false
has only substance units: false
name: Nicotinamide adenine dinucleotide phosphate - reduced
type: Species
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110045#_657cd06c_0d76_460d_805c_b6648fbbc65e
is: SBO:0000252
is encoded by: hsa:H77542
initial concentration: NaN
type: Species
has only substance units: false
initial amount: NaN
name: _H77542_1_r
boundary condition: true
constant: false

http://identifiers.org/biomodels.db/MODEL1310110045#_30902c31_11a4_4d21_9643_1568ab1ba628
type: Species
is encoded by: hsa:36
is: P45954
initial amount: NaN
name: ACADSB
is: SBO:0000252
boundary condition: true
has only substance units: false
initial concentration: NaN
constant: false

metaM prostgh2 c
constant: false
notes: FORMULA: C20H31O5 CHARGE: -1 INCHI: InChI=1S/C20H32O5/c1-2-3-6-9-15(21)12-13-17-16(18-14-19(17)25-24-18)10-7-4-5-8-11-20(22)23/h4,7,12-13,15-19,21H,2-3,5-6,8-11,14H2,1H3,(H,22,23)/p-1/b7-4-,13-12+/t15-,16+,17+,18-,19+/m0/s1 EHMN_ABBREVIATION: C00427
is: CHEBI:57405
boundary condition: false
initial concentration: 1.0
has only substance units: false
type: Species
initial amount: NaN
name: prostaglandin H2(1-)
is: SBO:0000247
is: HMDB01381

metaM gmp g
type: Species
is: HMDB01397
name: GMP(3-)
has only substance units: false
initial amount: NaN
notes: FORMULA: C10H12N5O8P CHARGE: -2 INCHI: InChI=1S/C10H14N5O8P/c11-10-13-7-4(8(18)14-10)12-2-15(7)9-6(17)5(16)3(23-9)1-22-24(19,20)21/h2-3,5-6,9,16-17H,1H2,(H2,19,20,21)(H3,11,13,14,18)/p-2/t3-,5-,6-,9-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00141 EHMN_ABBREVIATION: C00144
initial concentration: 1.0
is: SBO:0000247
is: CHEBI:58115
constant: false
boundary condition: false

metaR DURItn
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: NOTES:IT
kinetic law: MODEL1310110045#
type: Reaction
name: deoxyuridine transport in nucleus
is described by: ECO:0000000
reactant: MODEL1310110045#
fast: false
product: MODEL1310110045#
is: SBO:0000185
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110045#_afe67baf_eb49_49b9_9f93_09e24e3a3cca
has only substance units: false
type: Species
is: Q6I9V5
boundary condition: true
initial amount: NaN
name: SLC25A6
initial concentration: NaN
is encoded by: hsa:293
constant: false
is: SBO:0000252

metaM CE0785 m
boundary condition: false
initial amount: NaN
type: Species
has only substance units: false
notes: FORMULA: C35H54N7O17P3S CHARGE: -4 INCHI: InChI=1/C35H58N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-26(44)63-19-18-37-25(43)16-17-38-33(47)30(46)35(2,3)21-56-62(53,54)59-61(51,52)55-20-24-29(58-60(48,49)50)28(45)34(57-24)42-23-41-27-31(36)39-22-40-32(27)42/h8-9,11-12,22-24,28-30,34,45-46H,4-7,10,13-21H2,1-3H3,(H,37,43)(H,38,47)(H,51,52)(H,53,54)(H2,36,39,40)(H2,48,49,50)/p-4/b9-8-,12-11-/t24-,28+,29+,30u,34-/m0/s1 EHMN_ABBREVIATION: CE0785
is: CHEBI:57795
constant: false
name: cis,cis-myristo-5,8-dienoyl-CoA
is: SBO:0000247
initial concentration: 1.0

metaM hco3 m
constant: false
is: HMDB00595
boundary condition: false
has only substance units: false
name: Bicarbonate
is: C00288
type: Species
notes: FORMULA: CHO3 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00253 EHMN_ABBREVIATION: C00288
is: CHEBI:17544
is: SBO:0000247
initial amount: NaN
initial concentration: 1.0

metaM udp g
constant: false
has only substance units: false
name: UDP(3-)
initial concentration: 1.0
notes: FORMULA: C9H11N2O12P2 CHARGE: -3 INCHI: InChI=1S/C9H14N2O12P2/c12-5-1-2-11(9(15)10-5)8-7(14)6(13)4(22-8)3-21-25(19,20)23-24(16,17)18/h1-2,4,6-8,13-14H,3H2,(H,19,20)(H,10,12,15)(H2,16,17,18)/p-3/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00025 EHMN_ABBREVIATION: C00015
is: SBO:0000247
boundary condition: false
type: Species
is: CHEBI:58223
initial amount: NaN
is: HMDB00295

metaR r1428
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 0 AUTHORS: PMID:17045662 NOTES:
reversible: true
product: MODEL1310110045#
is: SBO:0000185
reactant: MODEL1310110045#
name: Free diffusion
type: Reaction
is described by: ECO:0000000
kinetic law: MODEL1310110045#

metaM cmp g
type: Species
has only substance units: false
initial amount: NaN
boundary condition: false
is: HMDB00095
initial concentration: 1.0
is: SBO:0000247
is: CHEBI:60377
name: CMP(2-)
notes: FORMULA: C9H12N3O8P CHARGE: -2 INCHI: InChI=1S/C9H14N3O8P/c10-5-1-2-12(9(15)11-5)8-7(14)6(13)4(20-8)3-19-21(16,17)18/h1-2,4,6-8,13-14H,3H2,(H2,10,11,15)(H2,16,17,18)/p-2/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00060 EHMN_ABBREVIATION: C00055
constant: false

metaM bilirub c
initial concentration: 1.0
constant: false
type: Species
name: bilirubin(2-)
notes: FORMULA: C33H34N4O6 CHARGE: -2 INCHI: InChI=1S/C33H36N4O6/c1-7-20-19(6)32(42)37-27(20)14-25-18(5)23(10-12-31(40)41)29(35-25)15-28-22(9-11-30(38)39)17(4)24(34-28)13-26-16(3)21(8-2)33(43)36-26/h7-8,13-14,34-35H,1-2,9-12,15H2,3-6H3,(H,36,43)(H,37,42)(H,38,39)(H,40,41)/p-2/b26-13-,27-14- HEPATONET_1.0_ABBREVIATION: HC00385 EHMN_ABBREVIATION: C00486
is: HMDB00054
initial amount: NaN
is: CHEBI:57977
boundary condition: false
has only substance units: false
is: SBO:0000247

metaM g6p c
type: Species
name: D-Glucose 6-phosphate
boundary condition: false
has only substance units: false
is: C00092
is: HMDB01401
is: SBO:0000247
initial concentration: 1.0
notes: FORMULA: C6H11O9P CHARGE: -2 INCHI: "1/C5H11/c1-3-5-4-2/h1,3-5H2,2H3 HEPATONET_1.0_ABBREVIATION: HC00094 EHMN_ABBREVIATION: C00092
initial amount: NaN
constant: false
is: CHEBI:61548

metaR r0472
type: Reaction
reversible: true
kinetic law: MODEL1310110045#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Nucleotide interconversion EC Number: 1.17.4.1 Confidence Level: 0 AUTHORS: PMID:6121703,PMID:8074691 NOTES:
fast: false
name: 2-Deoxyadenosine 5-diphosphate:oxidized-thioredoxin 2-oxidoreductase Purine metabolism EC:1.17.4.1
is: SBO:0000176
product: MODEL1310110045#
reactant: MODEL1310110045#

metaM ksi pre26 g
initial amount: NaN
constant: false
has only substance units: false
initial concentration: 1.0
is: SBO:0000247
boundary condition: false
is: CHEBI:28067
name: keratan sulfate I biosynthesis, precursor 26
type: Species
notes: FORMULA: C199H318N14O166S8X CHARGE: -9

metaR C226CPT2
reversible: false
kinetic law: MODEL1310110045#
type: Reaction
name: C226 transport into the mitochondria
notes: GENE_ASSOCIATION: (1376.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: PMID:11274214,PMID:1528846,PMID:1988962 NOTES:TDV
reactant: MODEL1310110045#
modifier: MODEL1310110045#
is: SBO:0000176
fast: false
is version of: http://identifiers.org/ec-code/2.3.1.21
is described by: ECO:0000000
product: MODEL1310110045#

metaR UMPK5n
is version of: http://identifiers.org/ec-code/2.7.4.14
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
reactant: MODEL1310110045#
modifier: MODEL1310110045#
type: Reaction
kinetic law: MODEL1310110045#
name: UMP kinase (dATP),nuclear
product: MODEL1310110045#
fast: false
is: SBO:0000176
reversible: true

metaM ile L m
type: Species
notes: FORMULA: C6H13NO2 CHARGE: 0 INCHI: InChI=1S/C6H13NO2/c1-3-4(2)5(7)6(8)9/h4-5H,3,7H2,1-2H3,(H,8,9)/t4-,5-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00334 EHMN_ABBREVIATION: C00407
is: HMDB00172
is: CHEBI:17191
boundary condition: false
has only substance units: false
name: L-isoleucine
initial amount: NaN
constant: false
initial concentration: 1.0
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110045#_8c06403f_6ed5_4f9e_877b_1c0db0ca44cc
type: Species
is: SBO:0000252
is encoded by: hsa:2592
initial concentration: NaN
constant: false
is: E7ET32
initial amount: NaN
has only substance units: false
boundary condition: true
name: GALT

metaR r0796
is version of: http://identifiers.org/ec-code/1.2.1.5
name: Ribitol:NAD+ 2-oxidoreductase Pentose and glucuronate interconversions EC:1.1.1.56
modifier: MODEL1310110045#
kinetic law: MODEL1310110045#
reactant: MODEL1310110045#
notes: GENE_ASSOCIATION: (220.1) or (218.1) or (221.1) or (222.1) or (U37519.1) SUBSYSTEM: Pentose phosphate pathway EC Number: Confidence Level: 0 AUTHORS: PMID:15234337 NOTES:
is described by: ECO:0000000
is: SBO:0000176
type: Reaction
reversible: true
fast: false
product: MODEL1310110045#

metaM gmp e
is: SBO:0000247
type: Species
constant: false
name: GMP(3-)
is: HMDB01397
has only substance units: false
notes: FORMULA: C10H12N5O8P CHARGE: -2 INCHI: InChI=1S/C10H14N5O8P/c11-10-13-7-4(8(18)14-10)12-2-15(7)9-6(17)5(16)3(23-9)1-22-24(19,20)21/h2-3,5-6,9,16-17H,1H2,(H2,19,20,21)(H3,11,13,14,18)/p-2/t3-,5-,6-,9-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00141 EHMN_ABBREVIATION: C00144
initial concentration: 1.0
initial amount: NaN
boundary condition: false
is: CHEBI:58115

metaM ru5p D r
name: D-ribulose 5-phosphate(2-)
initial concentration: 1.0
constant: false
initial amount: NaN
notes: FORMULA: C5H9O8P CHARGE: -2 INCHI: InChI=1S/C5H11O8P/c6-1-3(7)5(9)4(8)2-13-14(10,11)12/h4-6,8-9H,1-2H2,(H2,10,11,12)/p-2/t4-,5+/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00188
boundary condition: false
is: HMDB00618
type: Species
is: CHEBI:58121
is: SBO:0000247
has only substance units: false

metaM clpn hs c
type: Species
initial amount: NaN
boundary condition: false
is: CHEBI:15589
is: HMDB00156
notes: FORMULA: CHARGE: 0
has only substance units: false
is: SBO:0000247
initial concentration: 1.0
constant: false
name: clpn_hs[c]

http://identifiers.org/biomodels.db/MODEL1310110045#_c2f4aa5c_bd5f_4c82_8155_84e2509e0acc
is: Q5MY95
has only substance units: false
initial concentration: NaN
boundary condition: true
initial amount: NaN
type: Species
name: ENTPD8
is encoded by: hsa:377841
is: SBO:0000252
constant: false

metaM co2 e
is: HMDB01967
type: Species
has only substance units: false
boundary condition: false
initial concentration: 1.0
name: CO2
is: C00011
notes: FORMULA: CO2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00021 EHMN_ABBREVIATION: C00011
initial amount: NaN
is: SBO:0000247
is: CHEBI:16526
constant: false

metaM cmp e
type: Species
has only substance units: false
boundary condition: false
name: CMP(2-)
initial concentration: 1.0
notes: FORMULA: C9H12N3O8P CHARGE: -2 INCHI: InChI=1S/C9H14N3O8P/c10-5-1-2-12(9(15)11-5)8-7(14)6(13)4(20-8)3-19-21(16,17)18/h1-2,4,6-8,13-14H,3H2,(H2,10,11,15)(H2,16,17,18)/p-2/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00060 EHMN_ABBREVIATION: C00055
is: HMDB00095
initial amount: NaN
is: CHEBI:60377
is: SBO:0000247
constant: false

metaR RE3005M
is version of: http://identifiers.org/ec-code/4.2.1.107
reactant: MODEL1310110045#
is version of: http://identifiers.org/ec-code/1.1.1.35
is described by: ECO:0000000
product: MODEL1310110045#
kinetic law: MODEL1310110045#
type: Reaction
name: RE3005
is: SBO:0000176
notes: GENE_ASSOCIATION: (3295.1) or (1962.1) or (3033.1) or (3028.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.1.1.35 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:7775433 NOTES:
modifier: MODEL1310110045#
reversible: true
fast: false

metaM HC00342 m
constant: false
initial concentration: 1.0
is: SBO:0000247
name: cis-aconitate(3-)
boundary condition: false
has only substance units: false
initial amount: NaN
notes: FORMULA: C6H3O6 CHARGE: -3 INCHI: InChI=1S/C6H6O6/c7-4(8)1-3(6(11)12)2-5(9)10/h1H,2H2,(H,7,8)(H,9,10)(H,11,12)/p-3/b3-1- EHMN_ABBREVIATION: C00417
type: Species
is: CHEBI:16383

metaR r0797
fast: false
notes: GENE_ASSOCIATION: (220.1) or (218.1) or (221.1) or (222.1) or (U37519.1) SUBSYSTEM: Bile acid synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:12810727,PMID:6884990 NOTES:
product: MODEL1310110045#
is described by: ECO:0000000
is: SBO:0000176
kinetic law: MODEL1310110045#
type: Reaction
reversible: true
reactant: MODEL1310110045#
is version of: http://identifiers.org/ec-code/1.2.1.5
modifier: MODEL1310110045#
name: glycine N-choloyltransferase EC:2.3.1.65

metaM bilirub e
constant: false
has only substance units: false
type: Species
initial concentration: 1.0
is: HMDB00054
initial amount: NaN
notes: FORMULA: C33H34N4O6 CHARGE: -2 INCHI: InChI=1S/C33H36N4O6/c1-7-20-19(6)32(42)37-27(20)14-25-18(5)23(10-12-31(40)41)29(35-25)15-28-22(9-11-30(38)39)17(4)24(34-28)13-26-16(3)21(8-2)33(43)36-26/h7-8,13-14,34-35H,1-2,9-12,15H2,3-6H3,(H,36,43)(H,37,42)(H,38,39)(H,40,41)/p-2/b26-13-,27-14- HEPATONET_1.0_ABBREVIATION: HC00385 EHMN_ABBREVIATION: C00486
is: CHEBI:57977
name: bilirubin(2-)
boundary condition: false
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110045#_3b073cb5_2803_4f7c_aa01_166f2f3fee0f
type: Species
is encoded by: hsa:2629
initial amount: NaN
constant: false
initial concentration: NaN
is: SBO:0000252
is: B7Z5G2
name: GBA
has only substance units: false
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110045#_e3613bf3_91d4_4028_8ff6_5d7555305b6c
initial concentration: NaN
is: SBO:0000252
initial amount: NaN
name: PANK1
boundary condition: true
constant: false
type: Species
has only substance units: false
is encoded by: hsa:53354

metaM pail hs n
has only substance units: false
is: SBO:0000247
name: 1-phosphatidyl-1D-myo-inositol(1-)
boundary condition: false
initial amount: NaN
is: CHEBI:57880
constant: false
notes: FORMULA: C9H16O9PFULLRCO2FULLR2CO2 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC02009 EHMN_ABBREVIATION: C01194
type: Species
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110045#_c9db4f11_3205_4b0a_a0c9_41004d0c4b10
type: Species
has only substance units: false
initial concentration: NaN
boundary condition: true
is: SBO:0000252
name: KL
is encoded by: hsa:9365
constant: false
is: Q9UEF7
initial amount: NaN

metaM icit m
boundary condition: false
is: C00311
has only substance units: false
initial amount: NaN
notes: FORMULA: C6H5O7 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00266 EHMN_ABBREVIATION: C00311
is: CHEBI:16087
constant: false
type: Species
is: SBO:0000247
name: Isocitrate
initial concentration: 1.0
is: HMDB00193

http://identifiers.org/biomodels.db/MODEL1310110045#_2b2eb697_1cd8_4997_afdb_224fa786452a
name: _U37519_1_m
constant: false
is encoded by: hsa:U37519
initial amount: NaN
initial concentration: NaN
boundary condition: true
has only substance units: false
is: SBO:0000252
type: Species

http://identifiers.org/biomodels.db/MODEL1310110045#_fd4eb466_aa0f_4be5_8375_46a4077f66d6
boundary condition: true
has only substance units: false
constant: false
initial amount: NaN
initial concentration: NaN
name: ENPP3
is encoded by: hsa:5169
is: SBO:0000252
is: Q308M7
type: Species

http://identifiers.org/biomodels.db/MODEL1310110045#_89639464_24a5_48b9_bca9_03feddf491b3
initial concentration: NaN
boundary condition: true
is encoded by: hsa:2686
has only substance units: false
name: GGT7
type: Species
is: A0PJJ9
initial amount: NaN
constant: false
is: SBO:0000252

metaM acgal1p c
is: SBO:0000247
constant: false
initial amount: NaN
initial concentration: 1.0
has only substance units: false
is: HMDB06480
is: CHEBI:55404
name: N-Acetyl-D-galactosamine 1-phosphate
type: Species
boundary condition: false
notes: FORMULA: C8H14NO9P CHARGE: -2 INCHI: InChI=1S/C8H16NO9P/c1-3(11)9-5-7(13)6(12)4(2-10)17-8(5)18-19(14,15)16/h4-8,10,12-13H,2H2,1H3,(H,9,11)(H2,14,15,16)/t4-,5-,6+,7-,8?/m1/s1

metaM 2decdicoa m
constant: false
boundary condition: false
type: Species
name: 2,7-decadienoylcoa
has only substance units: false
initial concentration: 1.0
notes: FORMULA: C31H46N7O17P3S CHARGE: -4
initial amount: NaN
is: http://identifiers.org/pubchem.compound/16019966
is: SBO:0000247

metaR GALASE3ly
modifier: MODEL1310110045#
reversible: false
type: Reaction
is version of: http://identifiers.org/ec-code/3.4.16.5
kinetic law: MODEL1310110045#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.1.6.4
fast: false
product: MODEL1310110045#
is described by: ECO:0000000
name: beta-galactosidase, lysosomal
reactant: MODEL1310110045#
is version of: http://identifiers.org/ec-code/3.2.1.23
is version of: http://identifiers.org/ec-code/3.2.1.18
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) or (5476.1) and (2720.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.23 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD

metaM datp m
is: SBO:0000247
is: CHEBI:61404
is: HMDB01532
initial concentration: 1.0
name: dATP
notes: FORMULA: C10H12N5O12P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00129 EHMN_ABBREVIATION: C00131
type: Species
boundary condition: false
constant: false
has only substance units: false
initial amount: NaN
is: C00131

metaR PEAMNO
kinetic law: MODEL1310110045#
product: MODEL1310110045#
is version of: http://identifiers.org/ec-code/1.4.3.21
is described by: ECO:0000304
fast: false
modifier: MODEL1310110045#
reactant: MODEL1310110045#
reversible: false
notes: GENE_ASSOCIATION: (314.1) or (4128.1) or (26.1) or (4129.1) or (314.2) SUBSYSTEM: Phenylalanine metabolism EC Number: 1.4.3.6 Confidence Level: 2 AUTHORS: PMID:10389141,PMID:15035803,PMID:8920635,PMID:9653080 NOTES:JLR- Kegg reaction R02613
is: SBO:0000176
type: Reaction
name: Phenethylamine oxidase
is version of: http://identifiers.org/ec-code/1.4.3.22
is version of: http://identifiers.org/ec-code/1.4.3.4

metaM HC00342 c
constant: false
boundary condition: false
is: SBO:0000247
notes: FORMULA: C6H3O6 CHARGE: -3 INCHI: InChI=1S/C6H6O6/c7-4(8)1-3(6(11)12)2-5(9)10/h1H,2H2,(H,7,8)(H,9,10)(H,11,12)/p-3/b3-1- EHMN_ABBREVIATION: C00417
initial amount: NaN
is: CHEBI:16383
name: cis-aconitate(3-)
initial concentration: 1.0
has only substance units: false
type: Species

metaR r1147
reversible: true
type: Reaction
kinetic law: MODEL1310110045#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:16919238,PMID:17173541,PMID:18406340,PMID:8132483 NOTES:
is: SBO:0000185
fast: false
reactant: MODEL1310110045#
is described by: ECO:0000000
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
product: MODEL1310110045#

metaR NDPK1n
name: nucleoside-diphosphate kinase (ATP:GDP), nuclear
kinetic law: MODEL1310110045#
product: MODEL1310110045#
is version of: http://identifiers.org/ec-code/2.7.4.6
modifier: MODEL1310110045#
is described by: ECO:0000134
reactant: MODEL1310110045#
reversible: true
notes: GENE_ASSOCIATION: (4831.1 and 4830.1) or (4830.2 and 4831.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.6 Confidence Level: 4 AUTHORS: PMID:15242782 NOTES:Many nucleoside diphosphates (eight described) can act as acceptors. While many ribo- and deoxyribonucleoside triphosphates can act as donors, only ATP is chosen as a donor to minimize the number of total reactions.
fast: false
type: Reaction
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110045#_8574bf49_2a82_4e91_93d9_f8453a3b597f
type: Species
boundary condition: true
is encoded by: hsa:2645
initial amount: NaN
initial concentration: NaN
constant: false
is: SBO:0000252
name: GCK
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110045#_581cdee6_f507_4fea_8231_5670fd0ec8ed
initial amount: NaN
name: _H17063_1_m
has only substance units: false
boundary condition: true
is encoded by: hsa:H17063
type: Species
constant: false
is: SBO:0000252
initial concentration: NaN

metaM nadph x
is: HMDB00221
initial concentration: 1.0
boundary condition: false
name: Nicotinamide adenine dinucleotide phosphate - reduced
is: C00005
constant: false
has only substance units: false
is: SBO:0000247
notes: FORMULA: C21H26N7O17P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00015 EHMN_ABBREVIATION: C00005
is: CHEBI:57783
initial amount: NaN
type: Species

metaR r2525
is described by: ECO:0000000
is: SBO:0000185
product: MODEL1310110045#
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:10049700,PMID:10574970,PMID:11389679,PMID:11557028,PMID:11564694,PMID:12824232,PMID:12930836,PMID:14574404,PMID:16288981,PMID:911815 NOTES:
reactant: MODEL1310110045#
kinetic law: MODEL1310110045#
type: Reaction
fast: false
name: Major Facilitator(MFS) TCDB:2.A.1.44.1

metaM 5HPET c
type: Species
name: 5(S)-HPETE(1-)
constant: false
is: SBO:0000247
is: CHEBI:57450
boundary condition: false
is: HMDB01193
has only substance units: false
notes: FORMULA: C20H31O4 CHARGE: -1 INCHI: InChI=1S/C20H32O4/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-16-19(24-23)17-15-18-20(21)22/h6-7,9-10,12-14,16,19,23H,2-5,8,11,15,17-18H2,1H3,(H,21,22)/p-1/b7-6-,10-9-,13-12-,16-14+/t19-/m1/s1
initial concentration: 1.0
initial amount: NaN

metaM idp c
notes: FORMULA: C10H11N4O11P2 CHARGE: -3 INCHI: InChI=1S/C10H14N4O11P2/c15-6-4(1-23-27(21,22)25-26(18,19)20)24-10(7(6)16)14-3-13-5-8(14)11-2-12-9(5)17/h2-4,6-7,10,15-16H,1H2,(H,21,22)(H,11,12,17)(H2,18,19,20)/p-3/t4-,6-,7-,10-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00104 EHMN_ABBREVIATION: C00104
initial concentration: 1.0
has only substance units: false
constant: false
name: IDP(3-)
is: CHEBI:58280
boundary condition: false
initial amount: NaN
is: SBO:0000247
is: HMDB03335
type: Species

http://identifiers.org/biomodels.db/MODEL1310110045#_993e23d1_1c0e_4887_ae86_832805a0e673
has only substance units: false
type: Species
name: PIP5K1C
boundary condition: true
initial concentration: NaN
is: SBO:0000252
constant: false
is encoded by: hsa:23396
is: O60331
initial amount: NaN

metaM accoa m
type: Species
is: CHEBI:57288
name: Acetyl-CoA
is: HMDB01206
boundary condition: false
is: SBO:0000247
notes: FORMULA: C23H34N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00033 EHMN_ABBREVIATION: C00024
has only substance units: false
constant: false
is: C00024
initial concentration: 1.0
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110045#_1468d09c_b30a_4b0a_9b7d_4344cd2c0da5
boundary condition: true
is: SBO:0000252
is: Q9NRF8
is encoded by: hsa:56474
type: Species
constant: false
has only substance units: false
initial amount: NaN
name: CTPS2
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110045#_bd7509c6_1515_47a4_8bf6_890c89337120
is encoded by: hsa:9057
has only substance units: false
is: Q92536
type: Species
initial concentration: NaN
initial amount: NaN
boundary condition: true
name: SLC7A6
is: SBO:0000252
constant: false

metaR r1299
reactant: MODEL1310110045#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
type: Reaction
kinetic law: MODEL1310110045#
fast: false
reversible: false
name: Vesicular transport
is: SBO:0000185
product: MODEL1310110045#
is described by: ECO:0000000

metaR EX adp
kinetic law: MODEL1310110045#
reactant: MODEL1310110045#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: adp exchange
type: Reaction

metaR MM7B2g
product: MODEL1310110045#
reversible: false
kinetic law: MODEL1310110045#
type: Reaction
is: SBO:0000176
notes: GENE_ASSOCIATION: (4121.1) or (57134.1) or (10905.1) SUBSYSTEM: N-glycan synthesis EC Number: 3.2.1.113 Confidence Level: 0 AUTHORS: PMID:10915796,PMID:9592125 NOTES:NCD
name: mannosyl-oligosaccharide 1,2-alpha-mannosidase, Golgi apparatus
is version of: http://identifiers.org/ec-code/3.2.1.113
is described by: ECO:0000000
fast: false
reactant: MODEL1310110045#
modifier: MODEL1310110045#

http://identifiers.org/biomodels.db/MODEL1310110045#_a6cc3946_f8e1_4712_be8c_90fd611307fb
type: Species
boundary condition: true
name: PDE3B
is: A7E2E5
initial amount: NaN
is encoded by: hsa:5140
is: SBO:0000252
initial concentration: NaN
constant: false
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110045#_d07f2ee0_4ba3_4204_99d9_03be5c67d138
boundary condition: true
initial amount: NaN
has only substance units: false
name: ENTPD1
type: Species
is encoded by: hsa:953
is: Q86VV3
initial concentration: NaN
is: SBO:0000252
constant: false

metaR NDPK1m
fast: false
name: nucleoside-diphosphate kinase (ATP:GDP), mitochondrial
reversible: true
is described by: ECO:0000254
kinetic law: MODEL1310110045#
product: MODEL1310110045#
is version of: http://identifiers.org/ec-code/2.7.4.6
notes: GENE_ASSOCIATION: (4833.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.6 Confidence Level: 2 AUTHORS: PMID:9099850 NOTES:Many nucleoside diphosphates (eight described) can act as acceptors. While many ribo- and deoxyribonucleoside triphosphates can act as donors, only ATP is chosen as a donor to minimize the number of total reactions.
type: Reaction
reactant: MODEL1310110045#
is: SBO:0000176
modifier: MODEL1310110045#

http://identifiers.org/biomodels.db/MODEL1310110045#_97e9b48e_83e2_4893_8cc1_052393418e32
initial amount: NaN
is: O00217
is: SBO:0000252
initial concentration: NaN
type: Species
has only substance units: false
is encoded by: hsa:4728
constant: false
name: NDUFS8
boundary condition: true

metaR BAMPPALDOX
type: Reaction
is described by: ECO:0000212
kinetic law: MODEL1310110045#
fast: false
reactant: MODEL1310110045#
is version of: http://identifiers.org/ec-code/1.2.1.36
name: beta-Aminopropion aldehyde:NAD+ oxidoreductase
reversible: false
is version of: http://identifiers.org/ec-code/1.2.1.3
product: MODEL1310110045#
modifier: MODEL1310110045#
is: SBO:0000176
notes: GENE_ASSOCIATION: (8854.2) or (501.1) or (216.1) or (224.1) or (8854.3) or (223.1) or (8854.1) SUBSYSTEM: beta-Alanine metabolism EC Number: 1.2.1.36 Confidence Level: 1 AUTHORS: PMID:12586697 NOTES:SAB

metaR LEUGLYHYc
fast: false
type: Reaction
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 1 AUTHORS: most probable reaction. added during gap filling. NOTES:most probable reaction. added during gap filling.
name: hydrolysis of leucylglycine
is described by: ECO:0000134
is: SBO:0000176
product: MODEL1310110045#
reactant: MODEL1310110045#
kinetic law: MODEL1310110045#

metaR BTNDm
reactant: MODEL1310110045#
notes: GENE_ASSOCIATION: (686.1) SUBSYSTEM: Biotin metabolism EC Number: 3.5.1.12 Confidence Level: 4 AUTHORS: PMID:12459313,PMID:15059618 NOTES:Also acts on biotin esters IT
fast: false
type: Reaction
is described by: ECO:0000269
reversible: false
product: MODEL1310110045#
kinetic law: MODEL1310110045#
name: biotinidase (biotin), mitochondrial
is version of: http://identifiers.org/ec-code/3.5.1.12
modifier: MODEL1310110045#
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110045#_9d081661_397a_4cda_ad8c_a418874a32fa
is: P11310
type: Species
is encoded by: hsa:34
initial concentration: NaN
has only substance units: false
is: SBO:0000252
constant: false
boundary condition: true
initial amount: NaN
name: ACADM

metaM fn2m2masn g
initial amount: NaN
has only substance units: false
name: N4-{N-Acetyl-beta-D-glucosaminyl-(1,2)-alpha-D-mannosyl-(1,3)-[N-acetyl-beta-D-glucosaminyl-(1,2)-alpha-D-mannosyl-(1,6)]-beta-D-mannosyl-(1,4)-N-acetyl-beta-D-glucosaminyl-(1,4)-[alpha-L-fucosyl-(1,6)]-N-acetyl-beta-D-glucosaminyl}asparagine
is: CHEBI:32984
boundary condition: false
constant: false
notes: FORMULA: C56H93N4O39X CHARGE: 0 INCHI: InChI=1S/C60H100N6O42/c1-14-32(77)42(87)45(90)57(96-14)94-13-26-48(40(85)28(62-15(2)72)52(97-26)66-27(76)6-19(61)53(92)93)104-56-31(65-18(5)75)41(86)47(24(11-71)102-56)105-58-46(91)49(106-60-51(44(89)36(81)23(10-70)101-60)108-55-30(64-17(4)74)39(84)34(79)21(8-68)99-55)37(82)25(103-58)12-95-59-50(43(88)35(80)22(9-69)100-59)107-54-29(63-16(3)73)38(83)33(78)20(7-67)98-54/h14,19-26,28-52,54-60,67-71,77-91H,6-13,61H2,1-5H3,(H,62,72)(H,63,73)(H,64,74)(H,65,75)(H,66,76)(H,92,93)/t14-,19-,20+,21+,22+,23+,24+,25+,26+,28+,29+,30+,31+,32+,33+,34+,35+,36+,37+,38+,39+,40+,41+,42+,43-,44-,45-,46-,47+,48+,49-,50-,51-,52+,54-,55-,56-,57+,58-,59-,60+/m0/s1
is: SBO:0000247
initial concentration: 1.0
type: Species

metaR r0360
name: Glycolysis / Glyconeogenesis EC:2.7.1.1
is: SBO:0000176
kinetic law: MODEL1310110045#
reactant: MODEL1310110045#
reversible: false
type: Reaction
fast: false
product: MODEL1310110045#
notes: GENE_ASSOCIATION: (65985.1) or (R39999.1) SUBSYSTEM: Fructose and mannose metabolism EC Number: 2.7.1.1 Confidence Level: 0 AUTHORS: PMID:16906315,PMID:7061426,PMID:7150652,PMID:8717435 NOTES:
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/6.2.1.16
modifier: MODEL1310110045#

metaM accoa n
is: HMDB01206
is: SBO:0000247
name: acetyl-CoA(4-)
is: CHEBI:57288
constant: false
has only substance units: false
boundary condition: false
initial amount: NaN
notes: FORMULA: C23H34N7O17P3S CHARGE: -4 INCHI: InChI=1S/C23H38N7O17P3S/c1-12(31)51-7-6-25-14(32)4-5-26-21(35)18(34)23(2,3)9-44-50(41,42)47-49(39,40)43-8-13-17(46-48(36,37)38)16(33)22(45-13)30-11-29-15-19(24)27-10-28-20(15)30/h10-11,13,16-18,22,33-34H,4-9H2,1-3H3,(H,25,32)(H,26,35)(H,39,40)(H,41,42)(H2,24,27,28)(H2,36,37,38)/p-4/t13-,16-,17-,18+,22-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00033 EHMN_ABBREVIATION: C00024
type: Species
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110045#_642e8804_8187_45f1_8892_0ed24711e614
boundary condition: true
constant: false
name: SLC12A7
is encoded by: hsa:10723
initial concentration: NaN
is: SBO:0000252
type: Species
initial amount: NaN
is: Q9Y666
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110045#_083bd71b_2455_4210_990e_2b1fec023e39
is: SBO:0000252
constant: false
has only substance units: false
type: Species
is encoded by: hsa:3099
initial concentration: NaN
initial amount: NaN
boundary condition: true
name: HK2
is: P52789

metaM ksii core4 pre7 g
name: keratan sulfate II biosynthesis, precursor 7
boundary condition: false
is: SBO:0000247
initial concentration: 1.0
type: Species
initial amount: NaN
notes: FORMULA: C75H121N6O56SX CHARGE: -2
has only substance units: false
constant: false
is: HMDB00175
is: C00130
is: CHEBI:58053

http://identifiers.org/biomodels.db/MODEL1310110045#_6d0f3522_52b5_4e4f_a1c8_5ee163e5bcf7
initial concentration: NaN
type: Species
name: SLC26A1
constant: false
initial amount: NaN
boundary condition: true
has only substance units: false
is: SBO:0000252
is encoded by: hsa:10861

metaR BAAT1x
is: SBO:0000176
fast: false
modifier: MODEL1310110045#
notes: GENE_ASSOCIATION: (570.1) SUBSYSTEM: Bile acid synthesis EC Number: 2.3.1.65 Confidence Level: 4 AUTHORS: NOTES:glycine or taurine as substrates, produces glycocholic or taurocholic acids respectively NJ
reactant: MODEL1310110045#
product: MODEL1310110045#
is described by: ECO:0000269
name: bile acid Coenzyme A: amino acid N-acyltransferase
type: Reaction
is version of: http://identifiers.org/ec-code/2.3.1.65
reversible: false
kinetic law: MODEL1310110045#

http://identifiers.org/biomodels.db/MODEL1310110045#_2d4edbd4_3892_402a_a4df_1fae771f5062
is: Q6IBC0
is encoded by: hsa:3155
is: SBO:0000252
type: Species
name: HMGCL
initial concentration: NaN
initial amount: NaN
has only substance units: false
boundary condition: true
constant: false

metaM ksi deg39 l
initial amount: NaN
is: SBO:0000247
type: Species
constant: false
name: keratan sulfate I, degradation product 39
has only substance units: false
boundary condition: false
is: HMDB00143
notes: FORMULA: C48H81N3O36 CHARGE: 0
is: CHEBI:12936
initial concentration: 1.0

metaM prostgh2 e
boundary condition: false
name: prostaglandin H2(1-)
is: SBO:0000247
is: CHEBI:57405
constant: false
has only substance units: false
notes: FORMULA: C20H31O5 CHARGE: -1 INCHI: InChI=1S/C20H32O5/c1-2-3-6-9-15(21)12-13-17-16(18-14-19(17)25-24-18)10-7-4-5-8-11-20(22)23/h4,7,12-13,15-19,21H,2-3,5-6,8-11,14H2,1H3,(H,22,23)/p-1/b7-4-,13-12+/t15-,16+,17+,18-,19+/m0/s1 EHMN_ABBREVIATION: C00427
type: Species
initial concentration: 1.0
initial amount: NaN
is: HMDB01381

metaM ura c
is: SBO:0000247
is: HMDB00300
type: Species
constant: false
boundary condition: false
notes: FORMULA: C4H4N2O2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00106 EHMN_ABBREVIATION: C00106
is: CHEBI:17568
initial amount: NaN
has only substance units: false
name: Uracil
initial concentration: 1.0
is: C00106

metaR r1429
is described by: ECO:0000000
name: Free diffusion
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 0 AUTHORS: PMID:17045662 NOTES:
product: MODEL1310110045#
is: SBO:0000185
kinetic law: MODEL1310110045#
fast: false
reversible: true
reactant: MODEL1310110045#
type: Reaction

metaR EX 3mlda LPAREN e RPAREN
kinetic law: MODEL1310110045#
reactant: MODEL1310110045#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 3-Methylimidazoleacetic acid exchange
type: Reaction

metaR r1148
name: Active transport
fast: false
reversible: true
is: SBO:0000185
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:16919238,PMID:17173541,PMID:18406340,PMID:8132483 NOTES:
type: Reaction
product: MODEL1310110045#
kinetic law: MODEL1310110045#
reactant: MODEL1310110045#

metaR M13N2Tg
is described by: ECO:0000000
kinetic law: MODEL1310110045#
is version of: http://identifiers.org/ec-code/2.4.1.101
product: MODEL1310110045#
reversible: false
name: alpha-1,3-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase
fast: false
notes: GENE_ASSOCIATION: (4245.1) SUBSYSTEM: N-glycan synthesis EC Number: 2.4.1.101 Confidence Level: 0 AUTHORS: PMID:12621063 NOTES:NCD
type: Reaction
reactant: MODEL1310110045#
modifier: MODEL1310110045#
is: SBO:0000176

metaM bilirub r
constant: false
initial concentration: 1.0
type: Species
is: HMDB00054
is: CHEBI:57977
name: bilirubin(2-)
notes: FORMULA: C33H34N4O6 CHARGE: -2 INCHI: InChI=1S/C33H36N4O6/c1-7-20-19(6)32(42)37-27(20)14-25-18(5)23(10-12-31(40)41)29(35-25)15-28-22(9-11-30(38)39)17(4)24(34-28)13-26-16(3)21(8-2)33(43)36-26/h7-8,13-14,34-35H,1-2,9-12,15H2,3-6H3,(H,36,43)(H,37,42)(H,38,39)(H,40,41)/p-2/b26-13-,27-14- HEPATONET_1.0_ABBREVIATION: HC00385 EHMN_ABBREVIATION: C00486
initial amount: NaN
is: SBO:0000247
has only substance units: false
boundary condition: false

metaM co2 r
type: Species
has only substance units: false
is: HMDB01967
is: C00011
initial concentration: 1.0
is: SBO:0000247
name: CO2
boundary condition: false
is: CHEBI:16526
notes: FORMULA: CO2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00021 EHMN_ABBREVIATION: C00011
constant: false
initial amount: NaN

metaR M1316Mg
reactant: MODEL1310110045#
is version of: http://identifiers.org/ec-code/3.2.1.114
is described by: ECO:0000000
kinetic law: MODEL1310110045#
is: SBO:0000176
product: MODEL1310110045#
fast: false
reversible: false
type: Reaction
name: mannosyl-oligosaccharide 1,3-1,6-alpha-mannosidase
modifier: MODEL1310110045#
notes: GENE_ASSOCIATION: (4124.1) or (4122.1) SUBSYSTEM: N-glycan synthesis EC Number: 3.2.1.114 Confidence Level: 0 AUTHORS: PMID:8524845 NOTES:NCD

metaM idp e
is: CHEBI:58280
constant: false
initial concentration: 1.0
type: Species
notes: FORMULA: C10H11N4O11P2 CHARGE: -3 INCHI: InChI=1S/C10H14N4O11P2/c15-6-4(1-23-27(21,22)25-26(18,19)20)24-10(7(6)16)14-3-13-5-8(14)11-2-12-9(5)17/h2-4,6-7,10,15-16H,1H2,(H,21,22)(H,11,12,17)(H2,18,19,20)/p-3/t4-,6-,7-,10-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00104 EHMN_ABBREVIATION: C00104
initial amount: NaN
has only substance units: false
is: HMDB03335
boundary condition: false
is: SBO:0000247
name: IDP(3-)

metaR MHISOR
is version of: http://identifiers.org/ec-code/1.4.3.21
reactant: MODEL1310110045#
notes: GENE_ASSOCIATION: (26.1) or (314.1) or (8639.1) or (314.2) SUBSYSTEM: Histidine metabolism EC Number: 1.4.3.4 Confidence Level: 4 AUTHORS: PMID:12072962,PMID:15035803,PMID:8920635,PMID:9653080 NOTES:
reversible: false
fast: false
name: N-Methylhistamine:oxygen oxidoreductase (deaminating)
product: MODEL1310110045#
is described by: ECO:0000269
kinetic law: MODEL1310110045#
modifier: MODEL1310110045#
type: Reaction
is version of: http://identifiers.org/ec-code/1.4.3.22
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110045#_3dca3c65_cb6d_445d_b990_714c51383463
initial amount: NaN
is: SBO:0000252
constant: false
type: Species
has only substance units: false
is encoded by: hsa:4714
initial concentration: NaN
boundary condition: true
is: O95169
name: NDUFB8

http://identifiers.org/biomodels.db/MODEL1310110045#_abaecb1f_d2b5_420e_b9ea_5ef4fa08a489
is: SBO:0000252
is: P22102
boundary condition: true
constant: false
is encoded by: hsa:2618
has only substance units: false
name: GART
initial concentration: NaN
initial amount: NaN
type: Species

metaR r2382
fast: false
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
product: MODEL1310110045#
reversible: false
notes: GENE_ASSOCIATION: (215.1) or (U52111.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172 NOTES:
is described by: ECO:0000000
modifier: MODEL1310110045#
is: SBO:0000185
type: Reaction
kinetic law: MODEL1310110045#
reactant: MODEL1310110045#

metaM ksi deg6 l
notes: FORMULA: C210H336N15O184S11 CHARGE: -11
is: SBO:0000247
boundary condition: false
type: Species
is: CHEBI:12936
initial concentration: 1.0
name: keratan sulfate I, degradation product 6
has only substance units: false
initial amount: NaN
constant: false
is: HMDB00143

metaM ksii core2 deg5 l
is: HMDB00143
type: Species
is: CHEBI:12936
boundary condition: false
constant: false
initial concentration: 1.0
initial amount: NaN
is: SBO:0000247
notes: FORMULA: C50H82N4O38SX CHARGE: -1
name: keratan sulfate II (core 2-linked), degradation product 5
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110045#_68a25abf_661f_445b_99dc_794c80f18f8f
boundary condition: true
constant: false
initial concentration: NaN
has only substance units: false
is: SBO:0000252
type: Species
name: SLC26A1
initial amount: NaN
is encoded by: hsa:10861

http://identifiers.org/biomodels.db/MODEL1310110045#_09f0aa6f_fb6a_4f41_a545_c4edc6cf065e
type: Species
constant: false
is encoded by: hsa:3550
is: SBO:0000252
name: IK
initial amount: NaN
boundary condition: true
has only substance units: false
is: Q13123
initial concentration: NaN

metaM no e
is: C00533
constant: false
boundary condition: false
initial amount: NaN
name: Nitric oxide
notes: FORMULA: NO CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00415 EHMN_ABBREVIATION: C00533
type: Species
is: SBO:0000247
initial concentration: 1.0
is: HMDB03378
has only substance units: false
is: CHEBI:16480

metaR DGK2m
is: SBO:0000176
kinetic law: MODEL1310110045#
notes: GENE_ASSOCIATION: SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.8 Confidence Level: 2 AUTHORS: NOTES:Added EC- JLR IT
name: deoxyguanylate kinase (dGMP:dATP) (mitochondrial)
reactant: MODEL1310110045#
fast: false
type: Reaction
product: MODEL1310110045#
reversible: true
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110045#_3183ad6e_9fd4_45f1_942e_ef61a7f380c9
is encoded by: hsa:10965
is: SBO:0000252
is: P49753
constant: false
boundary condition: true
has only substance units: false
initial amount: NaN
type: Species
initial concentration: NaN
name: ACOT2

metaM 4ppcys m
initial concentration: 1.0
constant: false
initial amount: NaN
name: N-[(R)-4-phosphonatopantothenoyl]-L-cysteinate(3-)
boundary condition: false
is: HMDB01117
is: SBO:0000247
type: Species
is: CHEBI:59458
has only substance units: false
notes: FORMULA: C12H20N2O9PS CHARGE: -3 INCHI: InChI=1S/C12H23N2O9PS/c1-12(2,6-23-24(20,21)22)9(16)10(17)13-4-3-8(15)14-7(5-25)11(18)19/h7,9,16,25H,3-6H2,1-2H3,(H,13,17)(H,14,15)(H,18,19)(H2,20,21,22)/p-3/t7-,9-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01276 EHMN_ABBREVIATION: C04352

metaM co2 m
initial concentration: 1.0
initial amount: NaN
name: CO2
is: C00011
is: CHEBI:16526
constant: false
boundary condition: false
is: HMDB01967
notes: FORMULA: CO2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00021 EHMN_ABBREVIATION: C00011
is: SBO:0000247
type: Species
has only substance units: false

metaM cmp m
initial concentration: 1.0
initial amount: NaN
name: CMP(2-)
constant: false
notes: FORMULA: C9H12N3O8P CHARGE: -2 INCHI: InChI=1S/C9H14N3O8P/c10-5-1-2-12(9(15)11-5)8-7(14)6(13)4(20-8)3-19-21(16,17)18/h1-2,4,6-8,13-14H,3H2,(H2,10,11,15)(H2,16,17,18)/p-2/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00060 EHMN_ABBREVIATION: C00055
boundary condition: false
is: HMDB00095
is: SBO:0000247
type: Species
has only substance units: false
is: CHEBI:60377

metaM adrncoa x
is: C16170
constant: false
is: SBO:0000247
initial concentration: 1.0
type: Species
boundary condition: false
notes: FORMULA: C43H66N7O17P3S CHARGE: -4 INCHI: InChI=1/C43H70N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-34(52)71-27-26-45-33(51)24-25-46-41(55)38(54)43(2,3)29-64-70(61,62)67-69(59,60)63-28-32-37(66-68(56,57)58)36(53)42(65-32)50-31-49-35-39(44)47-30-48-40(35)50/h8-9,11-12,14-15,17-18,30-32,36-38,42,53-54H,4-7,10,13,16,19-29H2,1-3H3,(H,45,51)(H,46,55)(H,59,60)(H,61,62)(H2,44,47,48)(H2,56,57,58)/b9-8-,12-11-,15-14-,18-17-/t32-,36-,37-,38?,42-/m1/s1
name: adrenyl coenzyme A
has only substance units: false
initial amount: NaN
is: http://identifiers.org/pubchem.compound/47205480

metaM dgchol e
type: Species
is: HMDB00637
initial amount: NaN
boundary condition: false
notes: FORMULA: C26H43NO5 CHARGE: 0 INCHI: InChI=1S/C26H43NO5/c1-15(4-7-22(30)27-14-23(31)32)18-5-6-19-24-20(9-11-26(18,19)3)25(2)10-8-17(28)12-16(25)13-21(24)29/h15-21,24,28-29H,4-14H2,1-3H3,(H,27,30)(H,31,32)/p-1/t15-,16+,17-,18-,19+,20+,21-,24+,25+,26-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01472
name: glycochenodeoxycholate
has only substance units: false
constant: false
is: SBO:0000247
initial concentration: 1.0
is: CHEBI:36252

metaM 1pipdn2c x
type: Species
initial concentration: 1.0
initial amount: NaN
constant: false
boundary condition: false
name: 1-piperideine-2-carboxylate
notes: FORMULA: C6H9NO2 CHARGE: 0 INCHI: InChI=1S/C6H9NO2/c8-6(9)5-3-1-2-4-7-5/h1-4H2,(H,8,9)/p-1 EHMN_ABBREVIATION: C04092
has only substance units: false
is: CHEBI:16187
is: SBO:0000247
is: HMDB01084

metaR r2526
reversible: true
fast: false
is: SBO:0000185
product: MODEL1310110045#
kinetic law: MODEL1310110045#
reactant: MODEL1310110045#
type: Reaction
name: Major Facilitator(MFS) TCDB:2.A.1.44.1
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:10049700,PMID:10574970,PMID:11389679,PMID:11557028,PMID:11564694,PMID:12824232,PMID:12930836,PMID:14574404,PMID:16288981,PMID:911815 NOTES:
is described by: ECO:0000000

metaM HC00319 m
is: CHEBI:30794
initial amount: NaN
has only substance units: false
initial concentration: 1.0
name: Malonate
is: SBO:0000247
type: Species
constant: false
boundary condition: false
notes: FORMULA: C3H2O4 CHARGE: -2 INCHI: InChI=1S/C3H4O4/c4-2(5)1-3(6)7/h1H2,(H,4,5)(H,6,7)

http://identifiers.org/biomodels.db/MODEL1310110045#_7d2e3d83_83ba_4884_b2fd_22120846cd9e
boundary condition: true
initial concentration: NaN
has only substance units: false
is: P04062
is: SBO:0000252
constant: false
name: GBA
type: Species
initial amount: NaN
is encoded by: hsa:2629

http://identifiers.org/biomodels.db/MODEL1310110045#_15d8d1ad_5aa6_4a4f_98f0_42bcfa1f8291
is: P31040
is: SBO:0000252
constant: false
is encoded by: hsa:6389
initial amount: NaN
initial concentration: NaN
type: Species
boundary condition: true
has only substance units: false
name: SDHA

metaR r1298
is described by: ECO:0000000
type: Reaction
fast: false
kinetic law: MODEL1310110045#
name: Vesicular transport
product: MODEL1310110045#
reversible: false
is: SBO:0000185
reactant: MODEL1310110045#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:

metaR r2380
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
reactant: MODEL1310110045#
product: MODEL1310110045#
fast: false
reversible: true
kinetic law: MODEL1310110045#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:16919238,PMID:17173541,PMID:18406340,PMID:8132483 NOTES:
is: SBO:0000185
type: Reaction

metaM udp r
initial concentration: 1.0
initial amount: NaN
is: CHEBI:58223
is: SBO:0000247
constant: false
is: C00015
name: UDP
boundary condition: false
is: HMDB00295
has only substance units: false
notes: FORMULA: C9H11N2O12P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00025 EHMN_ABBREVIATION: C00015
type: Species

metaM HC01415 m
is: SBO:0000247
boundary condition: false
name: (2E)-Octenoyl-CoA
has only substance units: false
is: CHEBI:27537
initial concentration: 1.0
type: Species
initial amount: NaN
constant: false
notes: FORMULA: C29H44N7O17P3S CHARGE: -4 INCHI: InChI=1S/C29H48N7O17P3S/c1-4-5-6-7-8-9-20(38)57-13-12-31-19(37)10-11-32-27(41)24(40)29(2,3)15-50-56(47,48)53-55(45,46)49-14-18-23(52-54(42,43)44)22(39)28(51-18)36-17-35-21-25(30)33-16-34-26(21)36/h8-9,16-18,22-24,28,39-40H,4-7,10-15H2,1-3H3,(H,31,37)(H,32,41)(H,45,46)(H,47,48)(H2,30,33,34)(H2,42,43,44)/b9-8+/t18-,22-,23-,24+,28-/m1/s1 EHMN_ABBREVIATION: C05276

metaM datp n
notes: FORMULA: C10H12N5O12P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00129 EHMN_ABBREVIATION: C00131
is: SBO:0000247
type: Species
is: HMDB01532
name: dATP
is: CHEBI:61404
constant: false
is: C00131
initial amount: NaN
initial concentration: 1.0
has only substance units: false
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110045#_3ad52c8a_5d85_4e6f_800f_976165811b6d
initial amount: NaN
has only substance units: false
type: Species
is: SBO:0000252
boundary condition: true
name: GGT5
is encoded by: hsa:2687
is: P36269
initial concentration: NaN
constant: false

metaM cmp n
notes: FORMULA: C9H12N3O8P CHARGE: -2 INCHI: InChI=1S/C9H14N3O8P/c10-5-1-2-12(9(15)11-5)8-7(14)6(13)4(20-8)3-19-21(16,17)18/h1-2,4,6-8,13-14H,3H2,(H2,10,11,15)(H2,16,17,18)/p-2/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00060 EHMN_ABBREVIATION: C00055
is: CHEBI:60377
has only substance units: false
initial amount: NaN
name: CMP(2-)
boundary condition: false
constant: false
is: SBO:0000247
initial concentration: 1.0
is: HMDB00095
type: Species

http://identifiers.org/biomodels.db/MODEL1310110045#_27eefa33_88df_4d42_b089_fcff5eff3a70
is encoded by: hsa:158
is: P30566
is: SBO:0000252
initial amount: NaN
name: ADSL
initial concentration: NaN
type: Species
boundary condition: true
constant: false
has only substance units: false

metaR DCYTt
reactant: MODEL1310110045#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10899995 NOTES:
is described by: ECO:0000000
type: Reaction
kinetic law: MODEL1310110045#
name: deoxycytidine transport via diffusion
reversible: true
fast: false
product: MODEL1310110045#
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110045#_e3fdb9a5_f424_4231_92cd_7f6b9f60f573
is: Q9H845
constant: false
boundary condition: true
name: ACAD9
is encoded by: hsa:28976
is: SBO:0000252
type: Species
has only substance units: false
initial amount: NaN
initial concentration: NaN

metaR r0365
reversible: false
is version of: http://identifiers.org/ec-code/1.3.1.72
kinetic law: MODEL1310110045#
is: SBO:0000176
type: Reaction
product: MODEL1310110045#
fast: false
name: 3-hydroxypropanoate:NAD+ oxidoreductase beta-Alanine metabolism / Propanoate metabolism EC:1.1.1.59
notes: GENE_ASSOCIATION: (1718.1) SUBSYSTEM: Propanoate metabolism EC Number: 1.1.1.59 Confidence Level: 0 AUTHORS: PMID:13672942 NOTES:
is described by: ECO:0000000
reactant: MODEL1310110045#
modifier: MODEL1310110045#

http://identifiers.org/biomodels.db/MODEL1310110045#_e7797fdd_6ff7_4b60_9925_109e9a172ab7
boundary condition: true
constant: false
is: SBO:0000252
type: Species
has only substance units: false
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:1608
name: DGKG
is: P49619

metaR VALTAm
is version of: http://identifiers.org/ec-code/2.6.1.42
fast: false
name: valine transaminase, mitochondiral
is: SBO:0000176
product: MODEL1310110045#
reactant: MODEL1310110045#
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (587.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 2.6.1.42 Confidence Level: 4 AUTHORS: PMID:6933702,PMID:9165094 NOTES:NCD
reversible: true
modifier: MODEL1310110045#
type: Reaction
kinetic law: MODEL1310110045#

metaM no c
has only substance units: false
is: HMDB03378
initial amount: NaN
is: CHEBI:16480
type: Species
initial concentration: 1.0
is: SBO:0000247
is: C00533
notes: FORMULA: NO CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00415 EHMN_ABBREVIATION: C00533
boundary condition: false
name: Nitric oxide
constant: false

metaR r2381
type: Reaction
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
kinetic law: MODEL1310110045#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172 NOTES:
is described by: ECO:0000000
reactant: MODEL1310110045#
fast: false
reversible: false
product: MODEL1310110045#

metaR SUCCtp
fast: false
name: succinate transporter, peroxisome
is described by: ECO:0000000
kinetic law: MODEL1310110045#
reactant: MODEL1310110045#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 0 AUTHORS: NOTES:unknown mechanism NJ
reversible: true
is: SBO:0000185
product: MODEL1310110045#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110045#_b0c022a8_b00d_4fa5_917e_39f3883d200a
initial concentration: NaN
has only substance units: false
name: CYP27A1
initial amount: NaN
constant: false
is: SBO:0000252
is: Q02318
boundary condition: true
is encoded by: hsa:1593
type: Species

metaM glyphe e
notes: FORMULA: C11H14N2O3 CHARGE: 0
initial concentration: 1.0
is: SBO:0000247
boundary condition: false
type: Species
is: http://identifiers.org/pubchem.compound/97415
initial amount: NaN
has only substance units: false
name: Glycylphenylalanine
constant: false

metaR EX ksii core2 LPAREN e RPAREN
kinetic law: MODEL1310110045#
reactant: MODEL1310110045#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: keratan sulfate II (core 2-linked) exchange
type: Reaction

metaR FAOXC184C163m
kinetic law: MODEL1310110045#
product: MODEL1310110045#
reactant: MODEL1310110045#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation (C18:4-->C16:3)m
type: Reaction

metaR RE0453M
type: Reaction
reactant: MODEL1310110045#
is version of: http://identifiers.org/ec-code/2.7.4.6
reversible: true
kinetic law: MODEL1310110045#
is: SBO:0000176
notes: GENE_ASSOCIATION: (4833.1) SUBSYSTEM: Pyrimidine synthesis EC Number: 2.7.4.6 Confidence Level: 0 AUTHORS: PMID:3026468 NOTES:
fast: false
is described by: ECO:0000000
name: RE0453
modifier: MODEL1310110045#
product: MODEL1310110045#

metaM HC01434 x
constant: false
initial concentration: 1.0
boundary condition: false
is: CHEBI:58931
type: Species
name: oxalatosuccinate(3-)
notes: FORMULA: C6H3O7 CHARGE: -3 INCHI: InChI=1S/C6H6O7/c7-3(8)1-2(5(10)11)4(9)6(12)13/h2H,1H2,(H,7,8)(H,10,11)(H,12,13)/p-3 EHMN_ABBREVIATION: C05379
initial amount: NaN
has only substance units: false
is: SBO:0000247

metaM CE5236 c
has only substance units: false
type: Species
is: SBO:0000247
initial amount: NaN
is: HMDB03952
constant: false
is: CHEBI:28002
initial concentration: 1.0
name: O2'-4a-cyclic-tetrahydrobiopterin
notes: FORMULA: C9H13N5O3 CHARGE: 0 INCHI: InChI=1/C9H13N5O3/c1-3-5(15)4-2-11-6-9(14-4,17-3)7(16)13-8(10)12-6/h3-5,14-15H,2H2,1H3,(H3,10,11,12,13,16)/p+1/t3-,4u,5+,9u/m0/s1 EHMN_ABBREVIATION: CE5236
boundary condition: false

metaR EX cspg c LPAREN e RPAREN
kinetic law: MODEL1310110045#
reactant: MODEL1310110045#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: chondroitin sulfate C (GalNAc6S-GlcA) proteoglycan exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110045#_a3156f13_d49c_4fc1_b000_cae1c83f416e
type: Species
boundary condition: true
is: Q16795
constant: false
initial amount: NaN
is: SBO:0000252
has only substance units: false
is encoded by: hsa:4704
initial concentration: NaN
name: NDUFA9

metaR r0385
reversible: false
product: MODEL1310110045#
is: SBO:0000176
reactant: MODEL1310110045#
type: Reaction
fast: false
name: 3-methyl-2-oxobutanoate:[dihydrolipoyllysine-residue (2-methylpropanoyl)transferase] lipoyllysine 2-oxidoreductase (decarboxylating, acceptor-2-methylpropanoylating) EC:1.2.4.4
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 1.2.4.4 Confidence Level: 0 AUTHORS: PMID:11839747,PMID:12387880,PMID:15576032 NOTES:
kinetic law: MODEL1310110045#

metaR EX ach LPAREN e RPAREN
kinetic law: MODEL1310110045#
reactant: MODEL1310110045#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Acetylcholine exchange
type: Reaction

metaR RE0453N
reversible: true
notes: GENE_ASSOCIATION: (4830.1) or (4831.1) SUBSYSTEM: Pyrimidine synthesis EC Number: 2.7.4.6 Confidence Level: 0 AUTHORS: PMID:3026468 NOTES:
product: MODEL1310110045#
is: SBO:0000176
is described by: ECO:0000000
name: RE0453
reactant: MODEL1310110045#
modifier: MODEL1310110045#
is version of: http://identifiers.org/ec-code/2.7.4.6
kinetic law: MODEL1310110045#
type: Reaction
fast: false

metaM lnlncg r
boundary condition: false
is: SBO:0000247
initial concentration: 1.0
constant: false
notes: FORMULA: C18H29O2 CHARGE: -1 INCHI: InChI=1S/C18H30O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20/h6-7,9-10,12-13H,2-5,8,11,14-17H2,1H3,(H,19,20)/p-1/b7-6-,10-9-,13-12- HEPATONET_1.0_ABBREVIATION: HC01757 EHMN_ABBREVIATION: C06426
type: Species
is: HMDB03073
name: gamma-linolenate
has only substance units: false
is: CHEBI:32391
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110045#_c3fab229_60bf_41cf_a63b_0ade57112089
initial amount: NaN
type: Species
is encoded by: hsa:80271
initial concentration: NaN
constant: false
is: Q96DU7
is: SBO:0000252
name: ITPKC
has only substance units: false
boundary condition: true

metaR DNDPt12m
is: SBO:0000185
kinetic law: MODEL1310110045#
modifier: MODEL1310110045#
reactant: MODEL1310110045#
product: MODEL1310110045#
fast: false
name: dADP transport via ADP antiport
notes: GENE_ASSOCIATION: (60386.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:11226231 NOTES:IT
type: Reaction
reversible: false
is described by: ECO:0000269

metaM prostge1 e
boundary condition: false
is: HMDB01442
name: prostaglandin E1(1-)
initial concentration: 1.0
notes: FORMULA: C20H33O5 CHARGE: -1 INCHI: InChI=1S/C20H34O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h12-13,15-17,19,21,23H,2-11,14H2,1H3,(H,24,25)/p-1/b13-12+/t15-,16+,17+,19+/m0/s1 EHMN_ABBREVIATION: C04741
constant: false
initial amount: NaN
has only substance units: false
is: SBO:0000247
is: CHEBI:57397
type: Species

metaR FAOXC101C8m
kinetic law: MODEL1310110045#
product: MODEL1310110045#
reactant: MODEL1310110045#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C10:1-->C8)m
type: Reaction

metaR r0384
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 1.2.4.2 Confidence Level: 0 AUTHORS: PMID:10676873 NOTES:
is: SBO:0000176
type: Reaction
name: 2-oxoglutarate:[dihydrolipoyllysine-residue succinyltransferase]-lipoyllysine 2-oxidoreductase (decarboxylating, acceptor-succinylating) EC:1.2.4.2
fast: false
is described by: ECO:0000000
reversible: false
reactant: MODEL1310110045#
product: MODEL1310110045#
kinetic law: MODEL1310110045#

http://identifiers.org/biomodels.db/MODEL1310110045#_a41cdead_7461_48f2_9556_02d19808f0bb
is: Q9NQ66
is: SBO:0000252
initial concentration: NaN
name: PLCB1
boundary condition: true
is encoded by: hsa:23236
initial amount: NaN
has only substance units: false
constant: false
type: Species

metaM cs c deg4 l
name: chondroitin sulfate C (GalNAc6S-GlcA), degradation product 4
constant: false
notes: FORMULA: C31H49NO29S CHARGE: -2
initial concentration: 1.0
initial amount: NaN
type: Species
has only substance units: false
is: HMDB00812
boundary condition: false
is: SBO:0000247
is: CHEBI:16953

http://identifiers.org/biomodels.db/MODEL1310110045#_263575a0_8e80_44b9_84d7_d27183674abc
is: SBO:0000252
boundary condition: true
has only substance units: false
is: P09972
constant: false
is encoded by: hsa:230
type: Species
name: ALDOC
initial amount: NaN
initial concentration: NaN

metaM peamn c
is: CHEBI:225237
type: Species
boundary condition: false
constant: false
is: HMDB12275
initial concentration: 1.0
name: 2-phenylethanaminium
has only substance units: false
notes: FORMULA: C8H12N CHARGE: 1 INCHI: InChI=1S/C8H11N/c9-7-6-8-4-2-1-3-5-8/h1-5H,6-7,9H2/p+1 EHMN_ABBREVIATION: C05332
initial amount: NaN
is: SBO:0000247

metaM glyphe c
has only substance units: false
is: http://identifiers.org/pubchem.compound/97415
name: Glycylphenylalanine
initial concentration: 1.0
constant: false
boundary condition: false
initial amount: NaN
notes: FORMULA: C11H14N2O3 CHARGE: 0
type: Species
is: SBO:0000247

metaR B MANNASEly
is described by: ECO:0000000
fast: false
modifier: MODEL1310110045#
reversible: false
is: SBO:0000176
reactant: MODEL1310110045#
is version of: http://identifiers.org/ec-code/3.2.1.25
product: MODEL1310110045#
type: Reaction
kinetic law: MODEL1310110045#
name: beta-mannosidase, lysosomal
notes: GENE_ASSOCIATION: (4126.1) SUBSYSTEM: N-glycan degradation EC Number: 3.2.1.25 Confidence Level: 0 AUTHORS: PMID:9384606 NOTES:NCD

http://identifiers.org/biomodels.db/MODEL1310110045#_d4e9f0a5_8f2c_499f_aafd_4f7c55729813
type: Species
is encoded by: hsa:1757
boundary condition: true
name: SARDH
is: SBO:0000252
is: A8K596
initial amount: NaN
has only substance units: false
initial concentration: NaN
constant: false

metaR UDPG4E
is described by: ECO:0000134
reversible: true
product: MODEL1310110045#
type: Reaction
is: SBO:0000176
modifier: MODEL1310110045#
fast: false
notes: GENE_ASSOCIATION: (2582.1) or (2582.2) SUBSYSTEM: Galactose metabolism EC Number: 5.1.3.2 Confidence Level: 0 AUTHORS: PMID:11117433 NOTES:used yeast system to overexpress gene to determine mutant kinetic properties
reactant: MODEL1310110045#
kinetic law: MODEL1310110045#
name: UDPglucose 4-epimerase
is version of: http://identifiers.org/ec-code/5.1.3.2

http://identifiers.org/biomodels.db/MODEL1310110045#_2dfa2790_e457_4b29_badd_dcb6b3144466
initial concentration: NaN
boundary condition: true
type: Species
initial amount: NaN
constant: false
has only substance units: false
is: SBO:0000252
is: Q9Y6K8
is encoded by: hsa:26289
name: AK5

metaR r1116
kinetic law: MODEL1310110045#
reversible: true
reactant: MODEL1310110045#
fast: false
is: SBO:0000185
is described by: ECO:0000000
type: Reaction
product: MODEL1310110045#
name: ATP Exporter (ATP-E) TCDB:9.A.6.1.1
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:10913128,PMID:11147574,PMID:11557556,PMID:12269403,PMID:14613890,PMID:15210701,PMID:15958381,PMID:17124168,PMID:179827,PMID:18697206,PMID:3031070,PMID:3244197,PMID:9305892 NOTES:

metaM octe5coa m
boundary condition: false
name: 5-octenoylcoa
has only substance units: false
notes: FORMULA: C29H44N7O17P3S CHARGE: -4
initial concentration: 1.0
is: SBO:0000247
type: Species
is: http://identifiers.org/pubchem.compound/16019966
initial amount: NaN
constant: false

metaM gdpfuc g
initial amount: NaN
is: HMDB01095
has only substance units: false
initial concentration: 1.0
name: GDP-L-fucose(2-)
is: CHEBI:57984
is: SBO:0000247
notes: FORMULA: C16H23N5O15P2 CHARGE: -2 INCHI: InChI=1S/C16H25N5O15P2/c1-4-7(22)9(24)11(26)15(33-4)35-38(30,31)36-37(28,29)32-2-5-8(23)10(25)14(34-5)21-3-18-6-12(21)19-16(17)20-13(6)27/h3-5,7-11,14-15,22-26H,2H2,1H3,(H,28,29)(H,30,31)(H3,17,19,20,27)/p-2/t4-,5+,7+,8+,9+,10+,11-,14+,15?/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00275 EHMN_ABBREVIATION: C00325
constant: false
type: Species
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110045#_78ec08d6_d5a0_4278_b6bc_51128b1a839b
initial concentration: NaN
has only substance units: false
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:8879
constant: false
is: O95470
boundary condition: true
type: Species
name: SGPL1

http://identifiers.org/biomodels.db/MODEL1310110045#_79413e64_86c5_42b4_a81b_d55a1600d903
is encoded by: hsa:57379
initial concentration: NaN
constant: false
is: Q546Y9
boundary condition: true
initial amount: NaN
is: SBO:0000252
name: AICDA
has only substance units: false
type: Species

metaR 4NPHSFte
name: xenobiotic transport
kinetic law: MODEL1310110045#
is: SBO:0000185
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:9344226 NOTES:unknown mechanism, related cyp P450 metabolism reactions NJ. Biochemical, Rat
is described by: ECO:0000000
fast: false
type: Reaction
product: MODEL1310110045#
reactant: MODEL1310110045#

metaR DM Lcystin
kinetic law: MODEL1310110045#
reactant: MODEL1310110045#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: Demand for L-cystine
type: Reaction

metaR r1117
is: SBO:0000185
reversible: true
name: Facilitated diffusion
product: MODEL1310110045#
is described by: ECO:0000000
reactant: MODEL1310110045#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:17124168 NOTES:
fast: false
kinetic law: MODEL1310110045#

metaM C05280 m
notes: FORMULA: C33H50N7O17P3S CHARGE: -4 INCHI: InChI=1S/C33H54N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-24(42)61-17-16-35-23(41)14-15-36-31(45)28(44)33(2,3)19-54-60(51,52)57-59(49,50)53-18-22-27(56-58(46,47)48)26(43)32(55-22)40-21-39-25-29(34)37-20-38-30(25)40/h8-9,11-12,20-22,26-28,32,43-44H,4-7,10,13-19H2,1-3H3,(H,35,41)(H,36,45)(H,49,50)(H,51,52)(H2,34,37,38)(H2,46,47,48)/b9-8-,12-11-/t22-,26-,27-,28+,32-/m1/s1 EHMN_ABBREVIATION: C05280
boundary condition: false
has only substance units: false
is: HMDB03952
constant: false
type: Species
initial amount: NaN
is: SBO:0000247
name: cis,cis-3,6-Dodecadienoyl-CoA
is: CHEBI:28002
initial concentration: 1.0

metaM udpglcur c
constant: false
initial amount: NaN
is: HMDB00935
boundary condition: false
initial concentration: 1.0
is: SBO:0000247
has only substance units: false
is: CHEBI:58052
is: C00167
name: UDP-D-glucuronate
notes: FORMULA: C15H19N2O18P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00162 EHMN_ABBREVIATION: C00167
type: Species

http://identifiers.org/biomodels.db/MODEL1310110045#_5ffc3894_d0bd_4110_a479_5efb746f8561
type: Species
is: SBO:0000252
name: _AA664770_1_m
initial concentration: NaN
boundary condition: true
constant: false
initial amount: NaN
is encoded by: hsa:AA664770
has only substance units: false

metaR G14T10g
is version of: http://identifiers.org/ec-code/2.4.1.38
product: MODEL1310110045#
is version of: http://identifiers.org/ec-code/2.4.1.22
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (9334.1) or (2683.1) or (8703.1) or (8704.2) or (8704.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.38 Confidence Level: 4 AUTHORS: PMID:12512857,PMID:1903938,PMID:3094506,PMID:3144273,PMID:9405390,PMID:9435216 NOTES:Keratan sulfate I biosynthesis NCD
is: SBO:0000176
type: Reaction
is version of: http://identifiers.org/ec-code/2.4.1.90
reversible: false
name: beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase, Golgi
modifier: MODEL1310110045#
fast: false
kinetic law: MODEL1310110045#
reactant: MODEL1310110045#

metaR ACOAO7p
notes: GENE_ASSOCIATION: (51.1) or (51.2) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.3.6 Confidence Level: 4 AUTHORS: PMID:7876265,PMID:8159712 NOTES:NCD
reactant: MODEL1310110045#
is described by: ECO:0000269
modifier: MODEL1310110045#
reversible: false
fast: false
product: MODEL1310110045#
name: acyl-CoA oxidase (hexadecanoyl-CoA), peroxisomal
is version of: http://identifiers.org/ec-code/1.3.3.6
kinetic law: MODEL1310110045#
type: Reaction
is: SBO:0000176

metaM leu L e
is: SBO:0000247
initial concentration: 1.0
type: Species
has only substance units: false
notes: FORMULA: C6H13NO2 CHARGE: 0 INCHI: InChI=1S/C6H13NO2/c1-4(2)3-5(7)6(8)9/h4-5H,3,7H2,1-2H3,(H,8,9)/t5-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00121 EHMN_ABBREVIATION: C00123
name: L-leucine
constant: false
is: CHEBI:15603
boundary condition: false
is: HMDB00687
initial amount: NaN

metaM lnlncg l
name: gamma-linolenate
initial amount: NaN
is: SBO:0000247
initial concentration: 1.0
type: Species
is: CHEBI:32391
is: HMDB03073
boundary condition: false
constant: false
has only substance units: false
notes: FORMULA: C18H29O2 CHARGE: -1 INCHI: InChI=1S/C18H30O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20/h6-7,9-10,12-13H,2-5,8,11,14-17H2,1H3,(H,19,20)/p-1/b7-6-,10-9-,13-12- HEPATONET_1.0_ABBREVIATION: HC01757 EHMN_ABBREVIATION: C06426

metaM glcur l
is: HMDB00127
name: D-glucuronate
initial amount: NaN
notes: FORMULA: C6H9O7 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00182 EHMN_ABBREVIATION: C00191
is: SBO:0000247
constant: false
initial concentration: 1.0
type: Species
has only substance units: false
boundary condition: false
is: CHEBI:15748

metaM asn L m
is: HMDB00168
boundary condition: false
constant: false
is: CHEBI:17196
notes: FORMULA: C4H8N2O3 CHARGE: 0 INCHI: InChI=1S/C4H8N2O3/c5-2(4(8)9)1-3(6)7/h2H,1,5H2,(H2,6,7)(H,8,9)/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00148
name: L-asparagine
initial amount: NaN
has only substance units: false
type: Species
is: SBO:0000247
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110045#_d21e659a_e26c_4593_a08e_17dfb2e97573
is encoded by: hsa:8803
type: Species
initial amount: NaN
initial concentration: NaN
is: E5KS60
has only substance units: false
constant: false
boundary condition: true
is: SBO:0000252
name: SUCLA2

metaR r1538
is: SBO:0000185
kinetic law: MODEL1310110045#
notes: GENE_ASSOCIATION: (BE966236.1) or (6240.1) or (6241.1) or (50484.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14722772 NOTES:
is described by: ECO:0000000
name: Anion Exchanger (AE) TCDB:2.A.31.2.8
modifier: MODEL1310110045#
fast: false
type: Reaction
is version of: http://identifiers.org/ec-code/1.17.4.1
product: MODEL1310110045#
reactant: MODEL1310110045#
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110045#_b3a130ad_10ff_4681_9e0b_7773a9b40dbe
boundary condition: true
is encoded by: hsa:9380
type: Species
name: GRHPR
is: SBO:0000252
is: Q9UBQ7
constant: false
initial concentration: NaN
initial amount: NaN
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110045#_00670f83_b803_4d16_b055_cad332c23cc7
initial concentration: NaN
has only substance units: false
type: Species
is: SBO:0000252
boundary condition: true
constant: false
name: _D29675_1_c
is encoded by: hsa:D29675
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110045#_705d9823_6fd4_4476_80e7_c60dcfd9dc98
has only substance units: false
is: SBO:0000252
initial concentration: NaN
boundary condition: true
constant: false
name: _AV713053_1_m
is encoded by: hsa:AV713053
type: Species
initial amount: NaN

metaM gthrd e
is: SBO:0000247
is: CHEBI:57925
initial amount: NaN
notes: FORMULA: C10H16N3O6S CHARGE: -1 INCHI: InChI=1S/C10H17N3O6S/c11-5(10(18)19)1-2-7(14)13-6(4-20)9(17)12-3-8(15)16/h5-6,20H,1-4,11H2,(H,12,17)(H,13,14)(H,15,16)(H,18,19)/p-1/t5-,6-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00056 EHMN_ABBREVIATION: C00051
initial concentration: 1.0
boundary condition: false
name: glutathionate(1-)
has only substance units: false
constant: false
is: HMDB00125
type: Species

metaR RETt
is: SBO:0000185
type: Reaction
reversible: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:1503811 NOTES:IT
is described by: ECO:0000000
fast: false
reactant: MODEL1310110045#
product: MODEL1310110045#
kinetic law: MODEL1310110045#
name: Retinol transport via faciliated diffusion

metaM core3 g
is: SBO:0000247
boundary condition: false
type: Species
name: Core 3
initial amount: NaN
constant: false
notes: FORMULA: C16H27N2O10X CHARGE: 0
is: CHEBI:16250
initial concentration: 1.0
has only substance units: false

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is encoded by: hsa:39
initial amount: NaN
name: ACAT2
constant: false
is: Q9BWD1
type: Species
initial concentration: NaN
boundary condition: true
is: SBO:0000252
has only substance units: false

metaM leuktrA4 c
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is: SBO:0000247
boundary condition: false
initial amount: NaN
has only substance units: false
initial concentration: 1.0
is: CHEBI:57463
constant: false
is: HMDB01337
type: Species
name: leukotriene A4(1-)

http://identifiers.org/biomodels.db/MODEL1310110045#_f248d83a_39b0_47ec_a5cb_71fb4e0df148
boundary condition: true
type: Species
has only substance units: false
constant: false
is: Q86T14
is: SBO:0000252
is encoded by: hsa:51292
initial amount: NaN
name: GMPR2
initial concentration: NaN

metaR MG3er
type: Reaction
reversible: false
reactant: MODEL1310110045#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: N-glycan synthesis EC Number: Confidence Level: 0 AUTHORS: NOTES:EC-3.2.1.- NCD
is: SBO:0000176
kinetic law: MODEL1310110045#
product: MODEL1310110045#
name: mannosyl-oligosaccharide glucosidase, endoplasmic reticulum
is described by: ECO:0000000

metaR RE3272N
type: Reaction
product: MODEL1310110045#
notes: GENE_ASSOCIATION: SUBSYSTEM: Phosphatidylinositol phosphate metabolism EC Number: 3.1.3.66 Confidence Level: 0 AUTHORS: PMID:7556092 NOTES:
reactant: MODEL1310110045#
kinetic law: MODEL1310110045#
fast: false
is described by: ECO:0000000
name: RE3272
is: SBO:0000176
reversible: true

metaR r1018
kinetic law: MODEL1310110045#
type: Reaction
reactant: MODEL1310110045#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:10884298,PMID:6469982 NOTES:
product: MODEL1310110045#
fast: false
name: Transport reaction
reversible: true
is: SBO:0000185
is described by: ECO:0000000

metaM hexdicoa x
has only substance units: false
name: hexadecanedioylcoa
is: HMDB02288
notes: FORMULA: C37H59N7O19P3S CHARGE: -5
type: Species
is: SBO:0000247
boundary condition: false
initial concentration: 1.0
constant: false
initial amount: NaN

metaM chlstol r
constant: false
is: SBO:0000247
initial concentration: 1.0
name: 5alpha-cholesta-7,24-dien-3beta-ol
is: CHEBI:16290
notes: FORMULA: C27H44O CHARGE: 0 INCHI: InChI=1S/C27H44O/c1-18(2)7-6-8-19(3)23-11-12-24-22-10-9-20-17-21(28)13-15-26(20,4)25(22)14-16-27(23,24)5/h7,10,19-21,23-25,28H,6,8-9,11-17H2,1-5H3/t19-,20+,21+,23-,24+,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01452 EHMN_ABBREVIATION: C05439
has only substance units: false
is: HMDB06842
initial amount: NaN
boundary condition: false
type: Species

metaR EX malt LPAREN e RPAREN
kinetic law: MODEL1310110045#
reactant: MODEL1310110045#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Maltose exchange
type: Reaction

metaM 3decdicoa m
name: 3,7-decadienoylcoa
notes: FORMULA: C31H46N7O17P3S CHARGE: -4
is: SBO:0000247
constant: false
initial amount: NaN
is: http://identifiers.org/pubchem.compound/16019966
has only substance units: false
boundary condition: false
initial concentration: 1.0
type: Species

metaR FAOXC164GC163m
kinetic law: MODEL1310110045#
product: MODEL1310110045#
reactant: MODEL1310110045#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C16:4-->C16:3)gm
type: Reaction

metaR GFUCS
is described by: ECO:0000000
reactant: MODEL1310110045#
fast: false
kinetic law: MODEL1310110045#
is: SBO:0000176
product: MODEL1310110045#
reversible: false
is version of: http://identifiers.org/ec-code/1.1.1.271
modifier: MODEL1310110045#
type: Reaction
name: GDP-L-fucose synthase
notes: GENE_ASSOCIATION: (7264.1) SUBSYSTEM: Fructose and mannose metabolism EC Number: 1.1.1.271 Confidence Level: 0 AUTHORS: NOTES:Both human and Escherichia coli enzymes can use NADH in place of NADPH to a slight extent. IT

http://identifiers.org/biomodels.db/MODEL1310110045#_1db4e446_b248_4674_8e33_4c38f66e4e34
type: Species
boundary condition: true
is: Q9NRA0
has only substance units: false
is encoded by: hsa:56848
initial amount: NaN
initial concentration: NaN
constant: false
is: SBO:0000252
name: SPHK2

metaM gdpfuc c
is: HMDB01095
notes: FORMULA: C16H23N5O15P2 CHARGE: -2 INCHI: InChI=1S/C16H25N5O15P2/c1-4-7(22)9(24)11(26)15(33-4)35-38(30,31)36-37(28,29)32-2-5-8(23)10(25)14(34-5)21-3-18-6-12(21)19-16(17)20-13(6)27/h3-5,7-11,14-15,22-26H,2H2,1H3,(H,28,29)(H,30,31)(H3,17,19,20,27)/p-2/t4-,5+,7+,8+,9+,10+,11-,14+,15?/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00275 EHMN_ABBREVIATION: C00325
is: SBO:0000247
initial amount: NaN
boundary condition: false
is: CHEBI:57984
name: GDP-L-fucose(2-)
has only substance units: false
constant: false
initial concentration: 1.0
type: Species

http://identifiers.org/biomodels.db/MODEL1310110045#_0496323e_7d23_476c_a350_bc3ec02ade1d
is: Q9HC58
is encoded by: hsa:57419
has only substance units: false
constant: false
name: SLC24A3
initial concentration: NaN
boundary condition: true
is: SBO:0000252
initial amount: NaN
type: Species

metaR r1019
is: SBO:0000185
kinetic law: MODEL1310110045#
reactant: MODEL1310110045#
name: Postulated transport reaction
product: MODEL1310110045#
reversible: true
is described by: ECO:0000000
fast: false
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 0 AUTHORS: PMID:10884298,PMID:6469982 NOTES:

metaR 3MOPte
name: Transport of 3-methyl-2-oxopentanoate
type: Reaction
reactant: MODEL1310110045#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000185
kinetic law: MODEL1310110045#
fast: false
product: MODEL1310110045#
reversible: true

metaM L2aadp6sa c
is: HMDB01263
name: L-allysine
is: CHEBI:17917
has only substance units: false
initial amount: NaN
boundary condition: false
initial concentration: 1.0
notes: FORMULA: C6H11NO3 CHARGE: 0 INCHI: InChI=1S/C6H11NO3/c7-5(6(9)10)3-1-2-4-8/h4-5H,1-3,7H2,(H,9,10)/t5-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01230 EHMN_ABBREVIATION: C04076
is: SBO:0000247
constant: false
type: Species

metaM gthrd c
is: HMDB00125
boundary condition: false
has only substance units: false
notes: FORMULA: C10H16N3O6S CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00056 EHMN_ABBREVIATION: C00051
name: Reduced glutathione
is: CHEBI:57925
constant: false
is: C00051
type: Species
initial concentration: 1.0
initial amount: NaN
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110045#_c614a4a3_be00_4eba_9a7a_1fecfd437cbd
name: ABAT
boundary condition: true
is: SBO:0000252
is encoded by: hsa:18
type: Species
constant: false
initial amount: NaN
has only substance units: false
initial concentration: NaN

metaR NDPK10
reversible: true
type: Reaction
product: MODEL1310110045#
is described by: ECO:0000134
notes: GENE_ASSOCIATION: (4832.1) or (4831.1 and 4830.1) or (10201.1) or (29922.2) or (29922.1) or (4831.1 and 4830.2) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.6 Confidence Level: 4 AUTHORS: PMID:7050910 NOTES:Many nucleoside diphosphates (eight described) can act as acceptors. While many ribo- and deoxyribonucleoside triphosphates can act as donors, only ATP is chosen as a donor to minimize the number of total reactions.
fast: false
name: nucleoside-diphosphate kinase (ATP:dIDP)
modifier: MODEL1310110045#
kinetic law: MODEL1310110045#
is: SBO:0000176
reactant: MODEL1310110045#
is version of: http://identifiers.org/ec-code/2.7.4.6

http://identifiers.org/biomodels.db/MODEL1310110045#_7ec7448f_387b_4e64_99d5_3f0f0a9207d7
is: Q9BT22
has only substance units: false
initial amount: NaN
type: Species
is encoded by: hsa:56052
constant: false
boundary condition: true
is: SBO:0000252
initial concentration: NaN
name: ALG1

metaM leuktrA4 e
is: SBO:0000247
name: leukotriene A4(1-)
initial amount: NaN
notes: FORMULA: C20H29O3 CHARGE: -1 INCHI: InChI=1S/C20H30O3/c1-2-3-4-5-6-7-8-9-10-11-12-13-15-18-19(23-18)16-14-17-20(21)22/h6-7,9-13,15,18-19H,2-5,8,14,16-17H2,1H3,(H,21,22)/p-1/b7-6-,10-9-,12-11+,15-13+/t18-,19-/m0/s1 EHMN_ABBREVIATION: C00909
boundary condition: false
constant: false
is: HMDB01337
initial concentration: 1.0
has only substance units: false
is: CHEBI:57463
type: Species

metaM 1glyc hs e
has only substance units: false
initial amount: NaN
notes: FORMULA: C6H13O7PFULLRCO2 CHARGE: -1
boundary condition: false
type: Species
is: SBO:0000247
is: HMDB00224
name: 1 acyl phosphoglycerol
is: CHEBI:58190
initial concentration: 1.0
constant: false

metaR CYTDK2m
is: SBO:0000176
reactant: MODEL1310110045#
is described by: ECO:0000000
product: MODEL1310110045#
fast: false
kinetic law: MODEL1310110045#
name: cytidine kinase (ATP), mitochondrial
type: Reaction
reversible: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 1 AUTHORS: NOTES:IT

metaM glx c
boundary condition: false
is: HMDB00119
constant: false
notes: FORMULA: C2H1O3 CHARGE: -1 INCHI: InChI=1S/C2H2O3/c3-1-2(4)5/h1H,(H,4,5)/p-1 EHMN_ABBREVIATION: C00048
is: CHEBI:36655
is: SBO:0000247
name: glyoxylate
type: Species
has only substance units: false
initial concentration: 1.0
initial amount: NaN

metaR r2507
type: Reaction
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:17466261 NOTES:
product: MODEL1310110045#
reactant: MODEL1310110045#
is: SBO:0000185
fast: false
reversible: true
name: Utilized transport
kinetic law: MODEL1310110045#

metaR INSTt2r
modifier: MODEL1310110045#
is: SBO:0000185
type: Reaction
fast: false
reactant: MODEL1310110045#
reversible: true
is described by: ECO:0000269
kinetic law: MODEL1310110045#
notes: GENE_ASSOCIATION: (114134.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:11500374,PMID:12750891 NOTES:
product: MODEL1310110045#
name: inositol transport in via proton symport

metaM dcsptn1 c
constant: false
initial concentration: 1.0
name: docosa-4,7,10,13,16-pentaenoic acid
initial amount: NaN
has only substance units: false
is: http://identifiers.org/pubchem.compound/5282848
is: HMDB13123
boundary condition: false
notes: FORMULA: C22H33O2 CHARGE: -1 INCHI: InChI=1/C22H34O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22(23)24/h6-7,9-10,12-13,15-16,18-19H,2-5,8,11,14,17,20-21H2,1H3,(H,23,24)/b7-6-,10-9-,13-12-,16-15-,19-18-
type: Species
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110045#_230756f1_cdae_4622_85a2_9259da83fa2e
name: _AI348006_1_c
type: Species
initial concentration: NaN
is: SBO:0000252
constant: false
has only substance units: false
is encoded by: hsa:AI348006
boundary condition: true
initial amount: NaN

metaR RE3627M
notes: GENE_ASSOCIATION: (3295.1) or (1962.1) or (3033.1) or (3028.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.1.1.35 Confidence Level: 0 AUTHORS: PMID:11356164,PMID:7775433 NOTES:
is version of: http://identifiers.org/ec-code/4.2.1.107
type: Reaction
is version of: http://identifiers.org/ec-code/1.1.1.35
name: RE3627
fast: false
is: SBO:0000176
modifier: MODEL1310110045#
is described by: ECO:0000000
reversible: true
product: MODEL1310110045#
reactant: MODEL1310110045#
kinetic law: MODEL1310110045#

http://identifiers.org/biomodels.db/MODEL1310110045#_d103c645_22de_4128_8e3d_94ad1c8bf14e
is encoded by: hsa:58510
name: PRODH2
initial concentration: NaN
is: Q9UF12
is: SBO:0000252
has only substance units: false
type: Species
boundary condition: true
initial amount: NaN
constant: false

http://identifiers.org/biomodels.db/MODEL1310110045#_62280504_6677_467f_a5ef_22f6a1eacfa4
is: SBO:0000252
boundary condition: true
is encoded by: hsa:1346
name: COX7A1
initial concentration: NaN
constant: false
type: Species
is: P24310
has only substance units: false
initial amount: NaN

metaR PA HSter
kinetic law: MODEL1310110045#
is: SBO:0000185
is described by: ECO:0000000
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: PMID:10856717 NOTES:
name: phosphatidate scramblase
fast: false
reactant: MODEL1310110045#
product: MODEL1310110045#
type: Reaction

metaR KHte
reversible: true
fast: false
type: Reaction
kinetic law: MODEL1310110045#
reactant: MODEL1310110045#
name: KHte
is: SBO:0000185
is described by: ECO:0000134
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
product: MODEL1310110045#

metaR r2506
name: Utilized transport
kinetic law: MODEL1310110045#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:17466261 NOTES:
product: MODEL1310110045#
reversible: true
reactant: MODEL1310110045#
is: SBO:0000185
fast: false
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110045#_3a272e8a_2f7f_4440_a40d_cebfeed05e83
is: SBO:0000252
type: Species
initial concentration: NaN
has only substance units: false
is: Q7L266
is encoded by: hsa:80150
constant: false
initial amount: NaN
name: ASRGL1
boundary condition: true

metaM 10fthf c
type: Species
is: HMDB00972
is: SBO:0000247
is: C00234
initial amount: NaN
is: CHEBI:57454
boundary condition: false
notes: FORMULA: C20H21N7O7 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00212 EHMN_ABBREVIATION: C00234
initial concentration: 1.0
constant: false
has only substance units: false
name: 10-Formyltetrahydrofolate

http://identifiers.org/biomodels.db/MODEL1310110045#_7eb85bba_653f_4552_b8d6_1aba1dc74aad
is: Q86YT5
constant: false
boundary condition: true
type: Species
is encoded by: hsa:284111
name: SLC13A5
is: SBO:0000252
initial concentration: NaN
has only substance units: false
initial amount: NaN

metaR S6T16g
is described by: ECO:0000000
modifier: MODEL1310110045#
type: Reaction
product: MODEL1310110045#
kinetic law: MODEL1310110045#
is: SBO:0000176
reactant: MODEL1310110045#
reversible: false
notes: GENE_ASSOCIATION: (23563.2) or (9435.1) or (23563.1) or (10164.1) or (4166.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: Confidence Level: 4 AUTHORS: PMID:10330415,PMID:10491328,PMID:10913333,PMID:11278593,PMID:12403612,PMID:12855678,PMID:9722682 NOTES:NCD
name: galactose/N-acetylglucosamine 6-O-sulfotransferase, Golgi apparatus
fast: false

metaM trdrd c
is: SBO:0000247
has only substance units: false
constant: false
is: CHEBI:15967
notes: FORMULA: XH2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00289 EHMN_ABBREVIATION: C00342
name: Reduced thioredoxin
initial concentration: 1.0
type: Species
boundary condition: false
initial amount: NaN
is: C00342

metaM dcsptn1 e
initial amount: NaN
initial concentration: 1.0
is: http://identifiers.org/pubchem.compound/5282848
is: HMDB13123
name: docosa-4,7,10,13,16-pentaenoic acid
has only substance units: false
is: SBO:0000247
boundary condition: false
type: Species
notes: FORMULA: C22H33O2 CHARGE: -1 INCHI: InChI=1/C22H34O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22(23)24/h6-7,9-10,12-13,15-16,18-19H,2-5,8,11,14,17,20-21H2,1H3,(H,23,24)/b7-6-,10-9-,13-12-,16-15-,19-18-
constant: false

metaM HC01434 m
is: CHEBI:58931
boundary condition: false
initial amount: NaN
notes: FORMULA: C6H3O7 CHARGE: -3 INCHI: InChI=1S/C6H6O7/c7-3(8)1-2(5(10)11)4(9)6(12)13/h2H,1H2,(H,7,8)(H,10,11)(H,12,13)/p-3 EHMN_ABBREVIATION: C05379
is: SBO:0000247
type: Species
name: oxalatosuccinate(3-)
constant: false
initial concentration: 1.0
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110045#_c3a481b2_0e24_4853_b2f1_7818d75fb3f5
is: SBO:0000252
initial concentration: NaN
type: Species
constant: false
name: MGAT4B
is encoded by: hsa:11282
has only substance units: false
boundary condition: true
initial amount: NaN

metaR RE0453C
reactant: MODEL1310110045#
notes: GENE_ASSOCIATION: SUBSYSTEM: Pyrimidine synthesis EC Number: 2.7.4.6 Confidence Level: 0 AUTHORS: PMID:3026468 NOTES:
is described by: ECO:0000000
reversible: true
product: MODEL1310110045#
type: Reaction
fast: false
is: SBO:0000176
name: RE0453
kinetic law: MODEL1310110045#

http://identifiers.org/biomodels.db/MODEL1310110045#_7efb8dd5_c0df_45cb_a8de_03ee4c50898d
boundary condition: true
constant: false
initial amount: NaN
is encoded by: hsa:57786
has only substance units: false
type: Species
initial concentration: NaN
is: SBO:0000252
is: Q9NYW8
name: RBAK

http://identifiers.org/biomodels.db/MODEL1310110045#_e1cdc6bd_7da0_4c3c_835b_fd448ff3d894
is encoded by: hsa:6185
has part: P04844
boundary condition: true
is: SBO:0000297
constant: false
type: Species
has part: P04843
initial amount: NaN
is encoded by: hsa:1650
initial concentration: NaN
is encoded by: hsa:1603
has part: P39656
has part: Q53G02
name: DAD1:DDOST:RPN1:RPN2
has only substance units: false
is encoded by: hsa:6184

metaR PPAm
kinetic law: MODEL1310110045#
is described by: ECO:0000269
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.6.1.1
product: MODEL1310110045#
fast: false
reactant: MODEL1310110045#
modifier: MODEL1310110045#
reversible: false
type: Reaction
notes: GENE_ASSOCIATION: (27068.4) or (27068.1) or (27068.3) or (27068.2) SUBSYSTEM: Oxidative phosphorylation EC Number: 3.6.1.1 Confidence Level: 4 AUTHORS: PMID:10542310,PMID:15533045 NOTES:IF
name: inorganic diphosphatase

metaR NDP8
reactant: MODEL1310110045#
product: MODEL1310110045#
kinetic law: MODEL1310110045#
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (1841.1) SUBSYSTEM: Nucleotide interconversion EC Number: 3.6.1.6 Confidence Level: 4 AUTHORS: NOTES:
fast: false
modifier: MODEL1310110045#
is: SBO:0000176
name: nucleoside-diphosphatase (dUDP)
is version of: http://identifiers.org/ec-code/2.7.4.9
reversible: false
type: Reaction

metaM leu L c
constant: false
type: Species
initial concentration: 1.0
is: CHEBI:15603
is: SBO:0000247
notes: FORMULA: C6H13NO2 CHARGE: 0 INCHI: InChI=1S/C6H13NO2/c1-4(2)3-5(7)6(8)9/h4-5H,3,7H2,1-2H3,(H,8,9)/t5-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00121 EHMN_ABBREVIATION: C00123
boundary condition: false
name: L-leucine
initial amount: NaN
is: HMDB00687
has only substance units: false

metaR S6T4g
reversible: false
reactant: MODEL1310110045#
name: galactose/N-acetylglucosamine 6-O-sulfotransferase, Golgi apparatus
kinetic law: MODEL1310110045#
is described by: ECO:0000000
product: MODEL1310110045#
fast: false
is: SBO:0000176
modifier: MODEL1310110045#
type: Reaction
notes: GENE_ASSOCIATION: (23563.2) or (9435.1) or (23563.1) or (10164.1) or (4166.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: Confidence Level: 4 AUTHORS: PMID:10330415,PMID:10491328,PMID:10913333,PMID:11278593,PMID:12403612,PMID:12855678,PMID:9722682 NOTES:NCD

metaM asn L c
constant: false
is: CHEBI:17196
has only substance units: false
name: L-asparagine
initial amount: NaN
type: Species
notes: FORMULA: C4H8N2O3 CHARGE: 0 INCHI: InChI=1S/C4H8N2O3/c5-2(4(8)9)1-3(6)7/h2H,1,5H2,(H2,6,7)(H,8,9)/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00148
boundary condition: false
initial concentration: 1.0
is: HMDB00168
is: SBO:0000247

metaR CYTK12n
fast: false
name: cytidylate kinase (dCMP,dCTP),nuclear
is: SBO:0000176
reversible: true
product: MODEL1310110045#
modifier: MODEL1310110045#
type: Reaction
reactant: MODEL1310110045#
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
is version of: http://identifiers.org/ec-code/2.7.4.14
kinetic law: MODEL1310110045#

metaM arg L m
has only substance units: false
type: Species
is: SBO:0000247
constant: false
notes: FORMULA: C6H15N4O2 CHARGE: 1 INCHI: InChI=1S/C6H14N4O2/c7-4(5(11)12)2-1-3-10-6(8)9/h4H,1-3,7H2,(H,11,12)(H4,8,9,10)/p+1/t4-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00065
initial amount: NaN
name: L-argininium(1+)
initial concentration: 1.0
is: HMDB00517
boundary condition: false
is: CHEBI:32682

metaR r2508
name: Utilized transport
kinetic law: MODEL1310110045#
product: MODEL1310110045#
reactant: MODEL1310110045#
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:17466261 NOTES:
is: SBO:0000185
fast: false
type: Reaction
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110045#_499735ab_ab73_48ff_b5bd_9b2daa03d771
is: GO:0005783
is: SBO:0000290
constant: false
size: 1.0
spatial dimensions: 3.0
name: endoplasmic reticulum
type: Compartment

metaM xolest2 hs e
boundary condition: false
type: Species
name: cholesterol ester
constant: false
initial concentration: 1.0
initial amount: NaN
notes: FORMULA: C27H45FULLR2CO2 CHARGE: 0
is: CHEBI:17002
is: SBO:0000247
has only substance units: false

metaR ARACHDt2
reactant: MODEL1310110045#
product: MODEL1310110045#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11788354,PMID:12864740 NOTES:NJ
reversible: true
fast: false
is: SBO:0000185
name: fatty acid transport via diffusion
is described by: ECO:0000000
type: Reaction
kinetic law: MODEL1310110045#

http://identifiers.org/biomodels.db/MODEL1310110045#_4feabf6b_e5bd_4920_9710_9c3571ab3721
is encoded by: hsa:1347
has only substance units: false
is: H0UI06
constant: false
is: SBO:0000252
initial amount: NaN
boundary condition: true
initial concentration: NaN
type: Species
name: COX7A2

http://identifiers.org/biomodels.db/MODEL1310110045#_114885cb_e115_4989_bd56_5965fd73d5ef
is: SBO:0000252
is: P23743
constant: false
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:1606
has only substance units: false
name: DGKA
boundary condition: true
type: Species

metaR EX ncam LPAREN e RPAREN
kinetic law: MODEL1310110045#
reactant: MODEL1310110045#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Nicotinamide exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110045#_fac86c8e_727d_4687_8bae_ed5331367ab0
name: SLC23A2
boundary condition: true
initial amount: NaN
is encoded by: hsa:9962
type: Species
constant: false
initial concentration: NaN
has only substance units: false
is: SBO:0000252

metaR r0706
type: Reaction
is described by: ECO:0000000
modifier: MODEL1310110045#
kinetic law: MODEL1310110045#
product: MODEL1310110045#
reactant: MODEL1310110045#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.3.99.3
fast: false
notes: GENE_ASSOCIATION: (34.1) or (3712.1) or (R14373.1) SUBSYSTEM: Bile acid synthesis EC Number: 1.3.3.6 Confidence Level: 0 AUTHORS: PMID:11356170,PMID:8943006 NOTES:RE1814X
reversible: false
is version of: http://identifiers.org/ec-code/1.3.99.10
name: acyl-Coenzyme A dehydrogenase family, member 9 Bile acid biosynthesis EC:1.3.3.6

metaR biomass reaction
product: MODEL1310110045#
is described by: ECO:0000134
name: biomass_reaction
is: SBO:0000185
reversible: false
reactant: MODEL1310110045#
kinetic law: MODEL1310110045#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: AUTHORS: NOTES:
fast: false

metaR EX tcynt LPAREN e RPAREN
kinetic law: MODEL1310110045#
reactant: MODEL1310110045#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Thiocyanate exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110045#_b23249bd_f368_48cf_978c_4d382fdc9f79
initial concentration: NaN
name: MBOAT7
is: Q96N66
type: Species
is: SBO:0000252
has only substance units: false
initial amount: NaN
constant: false
is encoded by: hsa:79143
boundary condition: true

metaR EX CE5791 LPAREN e RPAREN
kinetic law: MODEL1310110045#
reactant: MODEL1310110045#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: kinetensin 4-8 exchange
type: Reaction

metaR FAOXC123C102m
kinetic law: MODEL1310110045#
product: MODEL1310110045#
reactant: MODEL1310110045#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C12:3-->C10:2)m
type: Reaction

metaM ptrc c
is: SBO:0000247
notes: FORMULA: C4H14N2 CHARGE: 2 HEPATONET_1.0_ABBREVIATION: HC00132 EHMN_ABBREVIATION: C00134
name: Putrescine
initial concentration: 1.0
type: Species
boundary condition: false
has only substance units: false
is: HMDB01414
initial amount: NaN
is: CHEBI:326268
is: C00134
constant: false

http://identifiers.org/biomodels.db/MODEL1310110045#_1ff20f2e_dee4_4229_a9bb_d6f6c5c63669
name: ST6GAL1
is: SBO:0000252
initial amount: NaN
is: B2R513
boundary condition: true
constant: false
has only substance units: false
is encoded by: hsa:6480
type: Species
initial concentration: NaN

metaR r0381
fast: false
product: MODEL1310110045#
is: SBO:0000176
name: hypotaurine:NAD+ oxidoreductase Taurine and hypotaurine metabolism EC:1.8.1.3
type: Reaction
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Taurine and hypotaurine metabolism EC Number: 1.8.1.3 Confidence Level: 0 AUTHORS: PMID:13979247,PMID:16680556,PMID:7295801 NOTES:
kinetic law: MODEL1310110045#
is described by: ECO:0000000
reactant: MODEL1310110045#

http://identifiers.org/biomodels.db/MODEL1310110045#_0dcd8bbf_d541_40d8_b60e_867caf66e4ce
is encoded by: hsa:155184
type: Species
initial concentration: NaN
is: Q6PXP3
has only substance units: false
name: SLC2A7
initial amount: NaN
boundary condition: true
is: SBO:0000252
constant: false

metaM psyltchol e
constant: false
initial concentration: 1.0
has only substance units: false
name: psyllium-taurocholic acid complex
initial amount: NaN
notes: FORMULA: C9642032H15428745NO8667421S CHARGE: 0
type: Species
is: http://identifiers.org/pubchem.compound/94244
is: SBO:0000247
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110045#_c074a731_89bc_4599_bf51_859f2e782670
type: Species
constant: false
initial amount: NaN
boundary condition: true
has only substance units: false
is: O43674
initial concentration: NaN
name: NDUFB5
is encoded by: hsa:4711
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110045#_cd45cfe2_ce57_4517_857e_211f3c00b842
initial amount: NaN
has part: P22392
type: Species
has only substance units: false
has part: P15531
boundary condition: true
is encoded by: hsa:4830
is: SBO:0000297
is encoded by: hsa:4831
name: NME1:NME2
initial concentration: NaN
constant: false

metaM asn L e
name: L-asparagine
initial concentration: 1.0
is: HMDB00168
constant: false
is: SBO:0000247
notes: FORMULA: C4H8N2O3 CHARGE: 0 INCHI: InChI=1S/C4H8N2O3/c5-2(4(8)9)1-3(6)7/h2H,1,5H2,(H2,6,7)(H,8,9)/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00148
initial amount: NaN
boundary condition: false
has only substance units: false
type: Species
is: CHEBI:17196

http://identifiers.org/biomodels.db/MODEL1310110045#_49a53fd1_37a0_491a_89a8_100b9050f34e
is: B7Z1R0
name: SLC4A10
has only substance units: false
initial concentration: NaN
boundary condition: true
constant: false
is: SBO:0000252
type: Species
initial amount: NaN
is encoded by: hsa:57282

metaR FAOXC163GC142m
kinetic law: MODEL1310110045#
product: MODEL1310110045#
reactant: MODEL1310110045#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C16:3-->C14:2)gm
type: Reaction

metaM bamppald c
is: HMDB01106
name: beta-Aminopropion aldehyde
initial amount: NaN
is: C05665
type: Species
is: http://identifiers.org/pubchem.compound/7975
boundary condition: false
initial concentration: 1.0
is: SBO:0000247
notes: FORMULA: C3H8NO CHARGE: 1 INCHI: InChI=1/C3H7NO/c4-2-1-3-5/h3H,1-2,4H2 EHMN_ABBREVIATION: C05665
constant: false
has only substance units: false

metaM C05957 r
boundary condition: false
is: CHEBI:27485
notes: FORMULA: C20H29O4 CHARGE: -1 INCHI: InChI=1S/C20H30O4/c1-2-3-6-10-17(21)13-14-18-16(12-15-19(18)22)9-7-4-5-8-11-20(23)24/h4,7,12-18,21H,2-3,5-6,8-11H2,1H3,(H,23,24)/b7-4-,14-13+/t16-,17-,18+/m0/s1 EHMN_ABBREVIATION: C05957
is: HMDB02710
constant: false
initial amount: NaN
initial concentration: 1.0
has only substance units: false
name: Prostaglandin J2
is: SBO:0000247
type: Species

metaM gthrd m
is: HMDB00125
is: SBO:0000247
name: glutathionate(1-)
initial amount: NaN
constant: false
has only substance units: false
initial concentration: 1.0
type: Species
notes: FORMULA: C10H16N3O6S CHARGE: -1 INCHI: InChI=1S/C10H17N3O6S/c11-5(10(18)19)1-2-7(14)13-6(4-20)9(17)12-3-8(15)16/h5-6,20H,1-4,11H2,(H,12,17)(H,13,14)(H,15,16)(H,18,19)/p-1/t5-,6-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00056 EHMN_ABBREVIATION: C00051
boundary condition: false
is: CHEBI:57925

metaM xoldiolone c
is: HMDB02197
name: 7alpha,12alpha-Dihydroxycholest-4-en-3-one
boundary condition: false
initial amount: NaN
initial concentration: 1.0
type: Species
constant: false
notes: FORMULA: C27H44O3 CHARGE: 0 INCHI: InChI=1S/C27H44O3/c1-16(2)7-6-8-17(3)20-9-10-21-25-22(15-24(30)27(20,21)5)26(4)12-11-19(28)13-18(26)14-23(25)29/h13,16-17,20-25,29-30H,6-12,14-15H2,1-5H3/t17-,20-,21+,22+,23-,24+,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01465 EHMN_ABBREVIATION: C05457
has only substance units: false
is: SBO:0000247
is: CHEBI:28477

metaM thcholstoic m
is: SBO:0000247
boundary condition: false
initial concentration: 1.0
is: CHEBI:18402
initial amount: NaN
is: HMDB03873
name: 3alpha,7alpha,12alpha-Trihydroxy-5beta-cholestanoate
constant: false
notes: FORMULA: C27H45O5 CHARGE: -1 INCHI: InChI=1S/C27H46O5/c1-15(6-5-7-16(2)25(31)32)19-8-9-20-24-21(14-23(30)27(19,20)4)26(3)11-10-18(28)12-17(26)13-22(24)29/h15-24,28-30H,5-14H2,1-4H3,(H,31,32)/t15-,16?,17+,18-,19-,20+,21+,22-,23+,24+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01340 EHMN_ABBREVIATION: C04722
has only substance units: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110045#_b7a0b7f9_3e27_48e1_9787_ece434b534f5
is: A8K003
has only substance units: false
type: Species
name: PMM1
initial amount: NaN
is encoded by: hsa:5372
constant: false
is: SBO:0000252
boundary condition: true
initial concentration: NaN

metaR r1010
is described by: ECO:0000000
name: Postulated transport reaction
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:1735445,PMID:18406340,PMID:1988962,PMID:2351134,PMID:2355017,PMID:6361812,PMID:7892212,PMID:8132483 NOTES:
type: Reaction
fast: false
product: MODEL1310110045#
kinetic law: MODEL1310110045#
reversible: true
reactant: MODEL1310110045#

http://identifiers.org/biomodels.db/MODEL1310110045#_1a15ec4f_3865_401c_8a35_7c3f3c659bf8
has only substance units: false
type: Species
is: P00915
name: CA1
initial amount: NaN
is: SBO:0000252
constant: false
initial concentration: NaN
boundary condition: true
is encoded by: hsa:759

http://identifiers.org/biomodels.db/MODEL1310110045#_f8a29ac3_f0f8_4c4d_9893_7b7b8266d7cb
initial concentration: NaN
constant: false
name: IDH2
initial amount: NaN
is: P48735
boundary condition: true
has only substance units: false
is: SBO:0000252
type: Species
is encoded by: hsa:3418

metaR EX sphs1p LPAREN e RPAREN
kinetic law: MODEL1310110045#
reactant: MODEL1310110045#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Sphingosine 1-phosphate exchange
type: Reaction

metaM ptrc e
name: Putrescine
boundary condition: false
is: CHEBI:326268
constant: false
notes: FORMULA: C4H14N2 CHARGE: 2 HEPATONET_1.0_ABBREVIATION: HC00132 EHMN_ABBREVIATION: C00134
is: SBO:0000247
initial concentration: 1.0
has only substance units: false
is: HMDB01414
initial amount: NaN
is: C00134
type: Species

http://identifiers.org/biomodels.db/MODEL1310110045#_a2a36440_ff02_433a_88d0_07e3017708e4
initial amount: NaN
is: SBO:0000252
has only substance units: false
is encoded by: hsa:26290
initial concentration: NaN
constant: false
is: Q9NY28
name: GALNT8
type: Species
boundary condition: true

metaR FOLt2le
product: MODEL1310110045#
reversible: true
fast: false
is: SBO:0000185
is described by: ECO:0000134
kinetic law: MODEL1310110045#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
reactant: MODEL1310110045#
type: Reaction
name: folate transport via anion exchange

metaR G6Pter
modifier: MODEL1310110045#
name: glucose 6-phosphate endoplasmic reticular transport via diffusion
reversible: true
kinetic law: MODEL1310110045#
reactant: MODEL1310110045#
type: Reaction
product: MODEL1310110045#
fast: false
is: SBO:0000185
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (2542.1) SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 4 AUTHORS: PMID:11032333,PMID:11140953,PMID:11879177,PMID:9428641 NOTES:NCD

metaR r1011
reactant: MODEL1310110045#
fast: false
kinetic law: MODEL1310110045#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:12543708 NOTES:
type: Reaction
name: Transport reaction
is: SBO:0000185
reversible: false
is described by: ECO:0000000
product: MODEL1310110045#

metaR G14T9g
is version of: http://identifiers.org/ec-code/2.4.1.38
fast: false
reactant: MODEL1310110045#
is: SBO:0000176
type: Reaction
notes: GENE_ASSOCIATION: (8703.1) or (2683.1) or (8704.2) or (8704.1) or (9334.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.38 Confidence Level: 4 AUTHORS: PMID:12512857,PMID:1903938,PMID:3094506,PMID:3144273,PMID:9405390,PMID:9435216 NOTES:Keratan sulfate I biosynthesis NCD
modifier: MODEL1310110045#
name: beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase, Golgi
reversible: false
is version of: http://identifiers.org/ec-code/2.4.1.22
product: MODEL1310110045#
kinetic law: MODEL1310110045#
is version of: http://identifiers.org/ec-code/2.4.1.90
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110045#_a85d3f4b_feeb_4687_a50f_34a782845023
constant: false
initial amount: NaN
name: MYO5B
is: Q9H6Y6
is: SBO:0000252
boundary condition: true
type: Species
has only substance units: false
initial concentration: NaN
is encoded by: hsa:4645

metaR BDMT L
product: MODEL1310110045#
is described by: ECO:0000000
name: GDPmannose:chitobiosyldiphosphodolichol beta-D-mannosyltransferase (liver)
modifier: MODEL1310110045#
kinetic law: MODEL1310110045#
type: Reaction
reactant: MODEL1310110045#
reversible: false
fast: false
notes: GENE_ASSOCIATION: (56052.1) SUBSYSTEM: N-glycan synthesis EC Number: 2.4.1.142 Confidence Level: 0 AUTHORS: NOTES:NCD
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.4.1.142

metaM thf m
type: Species
name: 5,6,7,8-Tetrahydrofolate
is: CHEBI:57453
boundary condition: false
constant: false
is: C00101
is: SBO:0000247
notes: FORMULA: C19H21N7O6 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00102 EHMN_ABBREVIATION: C00101
initial amount: NaN
is: HMDB01846
initial concentration: 1.0
has only substance units: false

metaR AG13T12g
notes: GENE_ASSOCIATION: (79369.1) or (374907.1) or (11041.1) or (146712.1) or (374907.2) or (93010.1) or (10331.1) or (10678.1) or (10678.2) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.149 Confidence Level: 4 AUTHORS: PMID:10747980,PMID:11042166,PMID:12061784,PMID:12512857,PMID:15560372,PMID:15620693,PMID:9405606 NOTES:NCD
modifier: MODEL1310110045#
reversible: false
fast: false
product: MODEL1310110045#
kinetic law: MODEL1310110045#
reactant: MODEL1310110045#
is: SBO:0000176
name: N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase, Golgi apparatus
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/2.4.1.149
type: Reaction

metaM glcur r
initial concentration: 1.0
is: SBO:0000247
boundary condition: false
has only substance units: false
initial amount: NaN
constant: false
is: CHEBI:15748
type: Species
name: D-glucuronate
notes: FORMULA: C6H9O7 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00182 EHMN_ABBREVIATION: C00191
is: HMDB00127

metaM btamp c
boundary condition: false
notes: FORMULA: C20H27N7O9PS CHARGE: -1 INCHI: InChI=1S/C20H28N7O9PS/c21-17-14-18(23-7-22-17)27(8-24-14)19-16(30)15(29)10(35-19)5-34-37(32,33)36-12(28)4-2-1-3-11-13-9(6-38-11)25-20(31)26-13/h7-11,13,15-16,19,29-30H,1-6H2,(H,32,33)(H2,21,22,23)(H2,25,26,31)/t9-,10+,11-,13-,15+,16+,19+/m0/s1 EHMN_ABBREVIATION: C05921
is: HMDB04220
has only substance units: false
constant: false
initial concentration: 1.0
is: CHEBI:3110
is: SBO:0000247
type: Species
name: Biotinyl-5'-AMP
initial amount: NaN

metaR EX pe hs LPAREN e RPAREN
kinetic law: MODEL1310110045#
reactant: MODEL1310110045#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for phosphatidylethanolamine
type: Reaction

metaR PACCOAL
type: Reaction
reactant: MODEL1310110045#
name: phenylacetate-CoA ligase
is described by: ECO:0000000
product: MODEL1310110045#
is: SBO:0000176
kinetic law: MODEL1310110045#
notes: GENE_ASSOCIATION: SUBSYSTEM: Phenylalanine metabolism EC Number: 6.2.1.30 Confidence Level: 2 AUTHORS: NOTES:JLR
reversible: false
fast: false

metaR FAOXC226C227m
kinetic law: MODEL1310110045#
product: MODEL1310110045#
reactant: MODEL1310110045#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C22:6-->C22:7)m
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110045#_fe93ddc7_9fac_4029_870e_2355416140b1
constant: false
initial concentration: NaN
initial amount: NaN
has only substance units: false
boundary condition: true
is encoded by: hsa:4717
is: O43677
type: Species
is: SBO:0000252
name: NDUFC1

metaR r1012
is described by: ECO:0000000
reversible: false
is: SBO:0000185
fast: false
name: Postulated transport reaction
product: MODEL1310110045#
type: Reaction
reactant: MODEL1310110045#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 0 AUTHORS: PMID:12543708,PMID:17034878 NOTES:
kinetic law: MODEL1310110045#

metaR EX retn LPAREN e RPAREN
kinetic law: MODEL1310110045#
reactant: MODEL1310110045#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Retinoate exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110045#_805a2bad_33f7_499f_a298_445d81bd0c56
has only substance units: false
initial concentration: NaN
is: SBO:0000252
type: Species
initial amount: NaN
constant: false
is: Q99643
name: SDHC
is encoded by: hsa:6391
boundary condition: true

metaR FATP6t
modifier: MODEL1310110045#
fast: false
reversible: true
is: SBO:0000185
type: Reaction
kinetic law: MODEL1310110045#
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (10998.1) or (11001.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10479480,PMID:12856180,PMID:15522816 NOTES:electroneutral transport NJ
reactant: MODEL1310110045#
product: MODEL1310110045#
is version of: http://identifiers.org/ec-code/6.2.1.3
name: fatty acid electroneutral transport
is version of: http://identifiers.org/ec-code/6.2.1.7

metaR CSNt
name: cytosine transport via facilated diffusion
kinetic law: MODEL1310110045#
notes: GENE_ASSOCIATION: (3177.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12006583,PMID:12838422 NOTES:IT
product: MODEL1310110045#
reversible: true
fast: false
is: SBO:0000185
reactant: MODEL1310110045#
is described by: ECO:0000269
type: Reaction
modifier: MODEL1310110045#

metaM 4nphsf c
is: CHEBI:35422
notes: FORMULA: C6H4NO6S CHARGE: -1 INCHI: InChI=1S/C6H5NO6S/c8-7(9)5-1-3-6(4-2-5)13-14(10,11)12/h1-4H,(H,10,11,12)
boundary condition: false
is: HMDB06492
initial concentration: 1.0
name: 4-Nitrophenyl sulfate
has only substance units: false
type: Species
initial amount: NaN
constant: false
is: SBO:0000247

metaR AG13T13g
notes: GENE_ASSOCIATION: (79369.1) or (374907.1) or (11041.1) or (146712.1) or (374907.2) or (93010.1) or (10331.1) or (10678.1) or (10678.2) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.149 Confidence Level: 4 AUTHORS: PMID:10747980,PMID:11042166,PMID:12061784,PMID:12512857,PMID:15560372,PMID:15620693,PMID:9405606 NOTES:NCD
fast: false
modifier: MODEL1310110045#
is version of: http://identifiers.org/ec-code/2.4.1.149
is: SBO:0000176
reversible: false
kinetic law: MODEL1310110045#
is described by: ECO:0000000
name: N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase, Golgi apparatus
type: Reaction
reactant: MODEL1310110045#
product: MODEL1310110045#

metaR EX for LPAREN e RPAREN
kinetic law: MODEL1310110045#
reactant: MODEL1310110045#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Formate exchange
type: Reaction

metaR PTPATe
kinetic law: MODEL1310110045#
reactant: MODEL1310110045#
fast: false
is described by: ECO:0000134
name: PTPATe
product: MODEL1310110045#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
reversible: true
is: SBO:0000176

metaM amet m
name: S-Adenosyl-L-methionine
has only substance units: false
type: Species
is: SBO:0000247
notes: FORMULA: C15H23N6O5S CHARGE: 1 HEPATONET_1.0_ABBREVIATION: HC00029 EHMN_ABBREVIATION: C00019
initial concentration: 1.0
is: CHEBI:15414
initial amount: NaN
boundary condition: false
is: HMDB01185
constant: false
is: C00019

metaM 10fthf m
boundary condition: false
type: Species
has only substance units: false
initial amount: NaN
initial concentration: 1.0
is: CHEBI:57454
is: SBO:0000247
is: HMDB00972
notes: FORMULA: C20H21N7O7 CHARGE: -2 INCHI: InChI=1S/C20H23N7O7/c21-20-25-16-15(18(32)26-20)23-11(7-22-16)8-27(9-28)12-3-1-10(2-4-12)17(31)24-13(19(33)34)5-6-14(29)30/h1-4,9,11,13,23H,5-8H2,(H,24,31)(H,29,30)(H,33,34)(H4,21,22,25,26,32)/p-2/t11-,13+/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00212 EHMN_ABBREVIATION: C00234
name: 10-formyltetrahydrofolate(2-)
constant: false

metaR r2090
fast: false
kinetic law: MODEL1310110045#
is: SBO:0000185
modifier: MODEL1310110045#
is described by: ECO:0000000
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
type: Reaction
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
product: MODEL1310110045#
reversible: true
reactant: MODEL1310110045#

metaR DNDPt22m
type: Reaction
name: dTDP transport via dUDP antiport
is described by: ECO:0000269
is: SBO:0000185
notes: GENE_ASSOCIATION: (60386.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:11226231 NOTES:IT
modifier: MODEL1310110045#
reversible: false
kinetic law: MODEL1310110045#
reactant: MODEL1310110045#
product: MODEL1310110045#
fast: false

http://identifiers.org/biomodels.db/MODEL1310110045#_811e2066_1eee_4673_a4ee_81233411d6f1
initial concentration: NaN
type: Species
constant: false
name: MTMR3
boundary condition: true
is encoded by: hsa:8897
is: SBO:0000252
has only substance units: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110045#_2033df84_da3b_4326_9571_817f56ac62c0
boundary condition: true
constant: false
initial concentration: NaN
name: PAICS
is: SBO:0000252
has only substance units: false
is encoded by: hsa:10606
type: Species
initial amount: NaN
is: P22234

http://identifiers.org/biomodels.db/MODEL1310110045#_99ebcf35_b2a1_4cb0_ad51_acb3a0548e18
type: Species
name: PPCDC
initial amount: NaN
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:60490
is: Q96CD2
has only substance units: false
constant: false
boundary condition: true

metaR DESAT22 1p
type: Reaction
reversible: false
reactant: MODEL1310110045#
fast: false
product: MODEL1310110045#
is: SBO:0000176
name: fatty acyl-CoA desaturase (n-C22:4CoA -> n-C22:5CoA)
kinetic law: MODEL1310110045#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid synthesis EC Number: 1.14.19.1 Confidence Level: 4 AUTHORS: NOTES:

http://identifiers.org/biomodels.db/MODEL1310110045#_1cdadf1e_27f5_41e8_89d4_31a4157b0ee0
constant: false
has only substance units: false
initial concentration: NaN
boundary condition: true
is encoded by: hsa:AV717590
type: Species
initial amount: NaN
is: SBO:0000252
name: _AV717590_1_c

metaR FAOXC1811603m
type: Reaction
reactant: MODEL1310110045#
kinetic law: MODEL1310110045#
product: MODEL1310110045#
notes: GENE_ASSOCIATION: (34.1) or (35.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.74 Confidence Level: 4 AUTHORS: NOTES:_5 rounds of beta ox, 1 loss of degree of unsat -> 4 fad oxidized c18:1 -> c8:0 4 step FAO lumped for 2 rounds also includes EC 1.1.1.35, 1.1.1.211, 1.3.3.6, 4.2.1.17, 4.2.1.74 NJ
modifier: MODEL1310110045#
name: Beta oxidation fatty acid
is version of: http://identifiers.org/ec-code/1.3.8.1
is described by: ECO:0000269
reversible: false
fast: false
is version of: http://identifiers.org/ec-code/1.3.99.3
is: SBO:0000176

metaR r2091
kinetic law: MODEL1310110045#
reversible: true
reactant: MODEL1310110045#
is described by: ECO:0000000
product: MODEL1310110045#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
fast: false
is: SBO:0000185
modifier: MODEL1310110045#
type: Reaction

metaM digalside hs c
type: Species
name: Digalactosylceramide
initial amount: NaN
notes: FORMULA: C30H56NO12FULLRCO CHARGE: 0 EHMN_ABBREVIATION: C06126
has only substance units: false
is: http://identifiers.org/pubchem.compound/8383
boundary condition: false
is: C06126
constant: false
is: SBO:0000247
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110045#_358da55b_6c4c_4a1b_87ed_f68f099c8598
initial amount: NaN
constant: false
is encoded by: hsa:728226
initial concentration: NaN
name: _728226_1_m
is: SBO:0000252
boundary condition: true
type: Species
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110045#_0c002416_3e81_4715_bdfc_e96d4fa1653a
is encoded by: hsa:3420
constant: false
initial amount: NaN
has only substance units: false
boundary condition: true
is: SBO:0000252
type: Species
name: IDH3B
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110045#_de2b8a20_ca1b_4476_a830_9f45849a32e8
initial amount: NaN
is: D3DX95
is encoded by: hsa:1103
is: SBO:0000252
constant: false
initial concentration: NaN
type: Species
name: CHAT
boundary condition: true
has only substance units: false

metaM ksi deg24 l
initial concentration: 1.0
boundary condition: false
type: Species
is: CHEBI:12936
name: keratan sulfate I, degradation product 24
has only substance units: false
initial amount: NaN
notes: FORMULA: C118H191N8O101S5 CHARGE: -5
is: HMDB00143
constant: false
is: SBO:0000247

metaR RE0689E
reversible: false
notes: GENE_ASSOCIATION: (26.1) SUBSYSTEM: Urea cycle EC Number: 1.4.3.6 Confidence Level: 0 AUTHORS: PMID:10047787,PMID:7040832 NOTES:
is version of: http://identifiers.org/ec-code/1.4.3.22
fast: false
kinetic law: MODEL1310110045#
modifier: MODEL1310110045#
is described by: ECO:0000000
reactant: MODEL1310110045#
type: Reaction
product: MODEL1310110045#
is: SBO:0000176
name: RE0689

metaR r0160
product: MODEL1310110045#
is: SBO:0000176
is described by: ECO:0000000
type: Reaction
kinetic law: MODEL1310110045#
reactant: MODEL1310110045#
notes: GENE_ASSOCIATION: (790.1) SUBSYSTEM: Glycine, serine, alanine and threonine metabolism EC Number: 2.6.1.51 Confidence Level: 0 AUTHORS: PMID:10347152,PMID:6469715 NOTES:
is version of: http://identifiers.org/ec-code/2.1.3.2
fast: false
modifier: MODEL1310110045#
name: L-Serine:pyruvate aminotransferase Glycine, serine and threonine metabolism EC:2.6.1.51
reversible: false

metaR INSt
kinetic law: MODEL1310110045#
reversible: true
type: Reaction
reactant: MODEL1310110045#
fast: false
notes: GENE_ASSOCIATION: (3177.1) or (2030.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10722669,PMID:12838422 NOTES:AR
is described by: ECO:0000269
is: SBO:0000185
product: MODEL1310110045#
name: Inosine transport (diffusion)
modifier: MODEL1310110045#

http://identifiers.org/biomodels.db/MODEL1310110045#_7d2cb0ab_7734_409b_8a2b_5d8a480a0e31
boundary condition: true
has only substance units: false
is encoded by: hsa:5092
initial amount: NaN
initial concentration: NaN
constant: false
is: SBO:0000252
type: Species
name: PCBD1

metaR r2092
is: SBO:0000185
is described by: ECO:0000000
kinetic law: MODEL1310110045#
modifier: MODEL1310110045#
type: Reaction
reactant: MODEL1310110045#
product: MODEL1310110045#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
reversible: true
fast: false

metaM Tn antigen l
type: Species
notes: FORMULA: C8H14NO5X CHARGE: 0
boundary condition: false
name: Tn antigen
is: C04383
has only substance units: false
initial amount: NaN
constant: false
is: SBO:0000247
initial concentration: 1.0

metaM arg L e
is: CHEBI:32682
name: L-argininium(1+)
is: HMDB00517
constant: false
initial concentration: 1.0
initial amount: NaN
is: SBO:0000247
notes: FORMULA: C6H15N4O2 CHARGE: 1 INCHI: InChI=1S/C6H14N4O2/c7-4(5(11)12)2-1-3-10-6(8)9/h4H,1-3,7H2,(H,11,12)(H4,8,9,10)/p+1/t4-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00065
has only substance units: false
type: Species
boundary condition: false

metaR ADRNt
type: Reaction
is described by: ECO:0000000
is: SBO:0000185
fast: false
name: fatty acid transport via diffusion
product: MODEL1310110045#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11788354,PMID:12864740 NOTES:NJ
kinetic law: MODEL1310110045#
reactant: MODEL1310110045#
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110045#_35d0d279_49cd_49d7_b23b_b6ea6dd6fc56
is encoded by: hsa:55343
has only substance units: false
initial amount: NaN
constant: false
is: SBO:0000252
name: SLC35C1
type: Species
is: B3KQH0
boundary condition: true
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110045#_b28c2bc7_f19c_471a_b430_bee18c74e7a3
is: SBO:0000252
has only substance units: false
initial amount: NaN
is encoded by: hsa:2876
is: P07203
constant: false
type: Species
initial concentration: NaN
boundary condition: true
name: GPX1

metaM ksii core4 pre10 g
initial amount: NaN
notes: FORMULA: C89H143N7O69S2X CHARGE: -3
name: keratan sulfate II biosynthesis, precursor 10
type: Species
initial concentration: 1.0
is: CHEBI:28067
boundary condition: false
has only substance units: false
is: SBO:0000247
constant: false

http://identifiers.org/biomodels.db/MODEL1310110045#_5e89fce8_6652_4bab_8444_1be23e2a9001
boundary condition: true
initial concentration: NaN
constant: false
is encoded by: hsa:AI653169
has only substance units: false
initial amount: NaN
is: SBO:0000252
type: Species
name: _AI653169_1_c

metaR r2093
kinetic law: MODEL1310110045#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
fast: false
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
modifier: MODEL1310110045#
product: MODEL1310110045#
reactant: MODEL1310110045#
is described by: ECO:0000000
is: SBO:0000185
reversible: true
type: Reaction

metaM 5tedtricoa m
initial amount: NaN
notes: FORMULA: C35H52N7O17P3S CHARGE: -4
boundary condition: false
has only substance units: false
is: SBO:0000247
type: Species
is: HMDB02288
constant: false
name: 5,8,11-tetradecatrienoylcoa
initial concentration: 1.0

metaM tdcoa m
is: CHEBI:57385
is: C02593
has only substance units: false
constant: false
type: Species
is: SBO:0000247
initial concentration: 1.0
name: Tetradecanoyl-CoA (n-C14:0CoA)
boundary condition: false
initial amount: NaN
notes: FORMULA: C35H58N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00971 EHMN_ABBREVIATION: C02593
is: HMDB01521

metaR URIt5le
name: uridine transport in via sodium symport (1:2)
is: SBO:0000185
type: Reaction
modifier: MODEL1310110045#
notes: GENE_ASSOCIATION: (64078.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
fast: false
reactant: MODEL1310110045#
kinetic law: MODEL1310110045#
product: MODEL1310110045#
reversible: false
is described by: ECO:0000134

http://identifiers.org/biomodels.db/MODEL1310110045#_53f5c313_7efd_45f4_b0ab_8daa07b6470e
has only substance units: false
is: O15244
initial concentration: NaN
type: Species
initial amount: NaN
is: SBO:0000252
constant: false
is encoded by: hsa:6582
name: SLC22A2
boundary condition: true

metaM CE5236 n
boundary condition: false
notes: FORMULA: C9H13N5O3 CHARGE: 0 INCHI: InChI=1/C9H13N5O3/c1-3-5(15)4-2-11-6-9(14-4,17-3)7(16)13-8(10)12-6/h3-5,14-15H,2H2,1H3,(H3,10,11,12,13,16)/p+1/t3-,4u,5+,9u/m0/s1 EHMN_ABBREVIATION: CE5236
constant: false
name: O2'-4a-cyclic-tetrahydrobiopterin
is: SBO:0000247
is: HMDB03952
is: CHEBI:28002
initial concentration: 1.0
has only substance units: false
type: Species
initial amount: NaN

metaR MAN6PI
notes: GENE_ASSOCIATION: (4351.1) SUBSYSTEM: Fructose and mannose metabolism EC Number: 5.3.1.8 Confidence Level: 2 AUTHORS: NOTES:
reactant: MODEL1310110045#
kinetic law: MODEL1310110045#
product: MODEL1310110045#
name: mannose-6-phosphate isomerase
reversible: true
is version of: http://identifiers.org/ec-code/5.3.1.8
fast: false
type: Reaction
is described by: ECO:0000304
is: SBO:0000176
modifier: MODEL1310110045#

metaM thf c
initial concentration: 1.0
initial amount: NaN
is: CHEBI:57453
name: 5,6,7,8-Tetrahydrofolate
is: SBO:0000247
boundary condition: false
has only substance units: false
notes: FORMULA: C19H21N7O6 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00102 EHMN_ABBREVIATION: C00101
constant: false
is: HMDB01846
is: C00101
type: Species

metaM c4crn c
notes: FORMULA: C11H21NO4 CHARGE: 0
initial concentration: 1.0
constant: false
name: butyryl carnitine
boundary condition: false
is: C02862
initial amount: NaN
type: Species
has only substance units: false
is: SBO:0000247
is: HMDB02013
is: http://identifiers.org/pubchem.compound/213144

metaM acgam c
initial concentration: 1.0
initial amount: NaN
is: HMDB00215
has only substance units: false
notes: FORMULA: C8H15NO6 CHARGE: 0 INCHI: InChI=1S/C8H15NO6/c1-4(12)9-5(2-10)7(14)8(15)6(13)3-11/h2,5-8,11,13-15H,3H2,1H3,(H,9,12)/t5-,6+,7+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00138 EHMN_ABBREVIATION: C00140
is: CHEBI:17411
constant: false
name: N-acetyl-D-glucosamine
boundary condition: false
type: Species
is: SBO:0000247

metaM 4nph e
is: SBO:0000247
name: 4-nitrophenolate
boundary condition: false
is: HMDB01232
notes: FORMULA: C6H5NO3 CHARGE: 0 INCHI: InChI=1S/C6H5NO3/c8-6-3-1-5(2-4-6)7(9)10/h1-4,8H/p-1 HEPATONET_1.0_ABBREVIATION: HC00570 EHMN_ABBREVIATION: C00870
has only substance units: false
is: CHEBI:57917
constant: false
type: Species
initial concentration: 1.0
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110045#_716354df_af38_4dd0_adee_4b263cd01b79
has only substance units: false
initial concentration: NaN
name: PRPS1
initial amount: NaN
is: SBO:0000252
constant: false
is encoded by: hsa:5631
boundary condition: true
is: P60891
type: Species

http://identifiers.org/biomodels.db/MODEL1310110045#_31d72ae5_859e_48a9_b3e8_60bd1fc90ca3
initial concentration: NaN
type: Species
has only substance units: false
constant: false
is: Q8IUC8
boundary condition: true
name: GALNT13
initial amount: NaN
is encoded by: hsa:114805
is: SBO:0000252

metaR GNMT
reversible: false
reactant: MODEL1310110045#
modifier: MODEL1310110045#
kinetic law: MODEL1310110045#
notes: GENE_ASSOCIATION: (27232.1) SUBSYSTEM: Glycine, serine, alanine and threonine metabolism EC Number: 2.1.1.20 Confidence Level: 4 AUTHORS: PMID:10843803,PMID:11810299 NOTES:
type: Reaction
fast: false
product: MODEL1310110045#
is described by: ECO:0000269
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.1.1.20
name: glycine N-methyltransferase

metaM xtsn c
initial concentration: 1.0
initial amount: NaN
notes: FORMULA: C10H12N4O6 CHARGE: 0 INCHI: InChI=1S/C10H12N4O6/c15-1-3-5(16)6(17)9(20-3)14-2-11-4-7(14)12-10(19)13-8(4)18/h2-3,5-6,9,15-17H,1H2,(H2,12,13,18,19)/t3-,5-,6-,9-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00838 EHMN_ABBREVIATION: C01762
name: xanthosine
is: CHEBI:18107
type: Species
is: HMDB00299
is: SBO:0000247
constant: false
boundary condition: false
has only substance units: false

metaM core4 g
is: CHEBI:16478
notes: FORMULA: C24H40N3O15X CHARGE: 0
name: Core 4
initial amount: NaN
initial concentration: 1.0
type: Species
boundary condition: false
is: SBO:0000247
has only substance units: false
constant: false

metaR r2094
modifier: MODEL1310110045#
is described by: ECO:0000000
kinetic law: MODEL1310110045#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
fast: false
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
reversible: true
type: Reaction
product: MODEL1310110045#
reactant: MODEL1310110045#
is: SBO:0000185

metaM cmp c
initial concentration: 1.0
constant: false
is: HMDB00095
initial amount: NaN
name: CMP
is: SBO:0000247
type: Species
is: CHEBI:60377
notes: FORMULA: C9H12N3O8P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00060 EHMN_ABBREVIATION: C00055
boundary condition: false
has only substance units: false
is: C00055

metaM co2 c
initial concentration: 1.0
is: C00011
constant: false
is: CHEBI:3313
notes: FORMULA: CO2 CHARGE: 0
initial amount: NaN
is: SBO:0000247
type: Species
boundary condition: false
has only substance units: false
name: CO2
is: HMDB01967

metaR FAEL183
name: fatty-acyl-CoA elongation (n-C18:3CoA)
is described by: ECO:0000000
reactant: MODEL1310110045#
fast: false
reversible: false
product: MODEL1310110045#
modifier: MODEL1310110045#
type: Reaction
kinetic law: MODEL1310110045#
is: SBO:0000176
notes: GENE_ASSOCIATION: (6785.1) SUBSYSTEM: Fatty acid synthesis EC Number: 2.3.1.86 Confidence Level: 4 AUTHORS: PMID:11138005,PMID:15189125 NOTES:fatty acid elongation step NJ

http://identifiers.org/biomodels.db/MODEL1310110045#_47928b57_e42e_4916_9d9d_dc5f404e9acc
constant: false
initial concentration: NaN
has only substance units: false
boundary condition: true
is encoded by: hsa:4706
is: SBO:0000252
initial amount: NaN
is: O14561
name: NDUFAB1
type: Species

metaR O2ter
reactant: MODEL1310110045#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD
type: Reaction
name: O2 transport, endoplasmic reticulum
product: MODEL1310110045#
kinetic law: MODEL1310110045#
is: SBO:0000185
reversible: true
fast: false

metaR G14T21g
name: beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase, Golgi
fast: false
notes: GENE_ASSOCIATION: (8703.1) or (2683.1) or (8704.2) or (8704.1) or (9334.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.38 Confidence Level: 4 AUTHORS: PMID:10747980,PMID:12512857,PMID:3094506,PMID:3144273,PMID:9405390,PMID:9435216 NOTES:Keratan sulfate II biosynthesis NCD
is version of: http://identifiers.org/ec-code/2.4.1.22
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.4.1.90
type: Reaction
modifier: MODEL1310110045#
reactant: MODEL1310110045#
kinetic law: MODEL1310110045#
product: MODEL1310110045#
is described by: ECO:0000000
reversible: false
is version of: http://identifiers.org/ec-code/2.4.1.38

http://identifiers.org/biomodels.db/MODEL1310110045#_9b1c87c1_5662_4296_a5cb_0d2e2f3e64f9
type: Species
name: SLC6A9
initial amount: NaN
is: SBO:0000252
initial concentration: NaN
has only substance units: false
is: P48067
boundary condition: true
constant: false
is encoded by: hsa:6536

metaR r1989
fast: false
name: Y+LAT2 Utilized transport
is described by: ECO:0000000
reversible: false
type: Reaction
is: SBO:0000185
reactant: MODEL1310110045#
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
modifier: MODEL1310110045#
kinetic law: MODEL1310110045#
product: MODEL1310110045#

metaM c4crn e
is: SBO:0000247
initial amount: NaN
initial concentration: 1.0
is: C02862
has only substance units: false
notes: FORMULA: C11H21NO4 CHARGE: 0
constant: false
is: HMDB02013
is: http://identifiers.org/pubchem.compound/213144
type: Species
name: butyryl carnitine
boundary condition: false

metaR r2095
fast: false
kinetic law: MODEL1310110045#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
reactant: MODEL1310110045#
is described by: ECO:0000000
is: SBO:0000185
product: MODEL1310110045#
modifier: MODEL1310110045#
type: Reaction
reversible: true

metaM r1p c
initial concentration: 1.0
notes: FORMULA: C5H9O8P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00456 EHMN_ABBREVIATION: C00442
type: Species
is: SBO:0000247
is: CHEBI:57720
boundary condition: false
is: C00442
has only substance units: false
is: HMDB01489
constant: false
name: alpha-D-Ribose 1-phosphate
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110045#_03d850d8_f7c5_4b68_85f7_dc983dcfe424
is: SBO:0000252
initial amount: NaN
name: CHAT
is: D3DX95
constant: false
has only substance units: false
type: Species
is encoded by: hsa:1103
initial concentration: NaN
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110045#_12d127fe_ec4f_407f_9f62_1bc460735cb9
type: Species
initial amount: NaN
has only substance units: false
initial concentration: NaN
is encoded by: hsa:5336
name: PLCG2
is: P16885
is: SBO:0000252
boundary condition: true
constant: false

metaR LEUPHELAT2tc
kinetic law: MODEL1310110045#
product: MODEL1310110045#
reactant: MODEL1310110045#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: Transport of L-Leucine into the cell and efflux of L-Phenylalanine out of the cell by LAT2 on the basolateral surfaces of kidney and intestine.
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110045#_d4fe3db7_08d7_48ad_84d5_9b8e626efca5
type: Species
is: SBO:0000252
boundary condition: true
constant: false
has only substance units: false
is: Q8TE04
name: PANK1
is encoded by: hsa:53354
initial concentration: NaN
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110045#_7d0d2f1c_049a_4ef7_8805_59679ee6a3b4
name: RRM2B
initial concentration: NaN
boundary condition: true
is: Q7LG56
type: Species
has only substance units: false
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:50484
constant: false

metaM 4ppan c
is: SBO:0000247
type: Species
name: D-4'-Phosphopantothenate
has only substance units: false
boundary condition: false
is: C03492
initial amount: NaN
is: HMDB01016
initial concentration: 1.0
constant: false
is: CHEBI:10986
notes: FORMULA: C9H15NO8P CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC01127 EHMN_ABBREVIATION: C03492

http://identifiers.org/biomodels.db/MODEL1310110045#_2a23376e_8ece_42e5_96dc_004530532781
type: Species
initial amount: NaN
has only substance units: false
is: Q14542
initial concentration: NaN
name: SLC29A2
is: SBO:0000252
constant: false
boundary condition: true
is encoded by: hsa:3177

metaR q10h2tc
reactant: MODEL1310110045#
type: Reaction
product: MODEL1310110045#
is: SBO:0000185
fast: false
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: NOTES:
kinetic law: MODEL1310110045#
is described by: ECO:0000134
name: transport of ubiquinol into cytosol

metaR RE1521M
name: RE1521
kinetic law: MODEL1310110045#
is version of: http://identifiers.org/ec-code/1.1.1.35
reactant: MODEL1310110045#
reversible: true
type: Reaction
notes: GENE_ASSOCIATION: (1892.1) or (3030.1) or (1962.1) or (3032.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.17 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:7923814,PMID:9568246,PMID:9920399 NOTES:
product: MODEL1310110045#
is version of: http://identifiers.org/ec-code/4.2.1.17
is: SBO:0000176
fast: false
modifier: MODEL1310110045#
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/2.3.1.16

metaR DCYTDn
kinetic law: MODEL1310110045#
is: SBO:0000176
is described by: ECO:0000254
type: Reaction
notes: GENE_ASSOCIATION: (57379.1) SUBSYSTEM: Nucleotide interconversion EC Number: 3.5.4.14 Confidence Level: 2 AUTHORS: PMID:15087440 NOTES:IT
modifier: MODEL1310110045#
fast: false
is version of: http://identifiers.org/ec-code/3.5.4.5
product: MODEL1310110045#
reversible: false
reactant: MODEL1310110045#
name: deoxycytidine deaminase, nuclear

metaR r2096
is described by: ECO:0000000
modifier: MODEL1310110045#
fast: false
type: Reaction
kinetic law: MODEL1310110045#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
reversible: true
reactant: MODEL1310110045#
is: SBO:0000185
product: MODEL1310110045#

metaR r1443
is: SBO:0000176
kinetic law: MODEL1310110045#
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 0 AUTHORS: PMID:17603022,PMID:6240978,PMID:7876265 NOTES:
reversible: false
reactant: MODEL1310110045#
product: MODEL1310110045#
fast: false
type: Reaction
is described by: ECO:0000000
name: EC:1.3.3.6

metaM 3ddecdicoa m
notes: FORMULA: C33H50N7O17P3S CHARGE: -4
is: SBO:0000247
name: 3,6-dodecadienoylcoa
initial amount: NaN
type: Species
is: HMDB03952
has only substance units: false
initial concentration: 1.0
is: C05280
boundary condition: false
constant: false

metaR r0921
fast: false
type: Reaction
name: Postulated transport reaction
is: SBO:0000185
kinetic law: MODEL1310110045#
is described by: ECO:0000000
product: MODEL1310110045#
reactant: MODEL1310110045#
reversible: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:12006583,PMID:1260500,PMID:12838422,PMID:14747464,PMID:16595656,PMID:168203,PMID:17187757,PMID:17279066,PMID:3728675,PMID:6778226,PMID:7419607,PMID:7479738,PMID:8438778 NOTES:

metaM arachdcoa m
initial amount: NaN
type: Species
boundary condition: false
is: SBO:0000247
has only substance units: false
is: CHEBI:57368
initial concentration: 1.0
constant: false
name: arachidonoyl-CoA(4-)
is: HMDB06523
notes: FORMULA: C41H62N7O17P3S CHARGE: -4 INCHI: InChI=1S/C41H66N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-32(50)69-25-24-43-31(49)22-23-44-39(53)36(52)41(2,3)27-62-68(59,60)65-67(57,58)61-26-30-35(64-66(54,55)56)34(51)40(63-30)48-29-47-33-37(42)45-28-46-38(33)48/h8-9,11-12,14-15,17-18,28-30,34-36,40,51-52H,4-7,10,13,16,19-27H2,1-3H3,(H,43,49)(H,44,53)(H,57,58)(H,59,60)(H2,42,45,46)(H2,54,55,56)/p-4/b9-8-,12-11-,15-14-,18-17-/t30-,34-,35-,36+,40-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01986 EHMN_ABBREVIATION: C02249

http://identifiers.org/biomodels.db/MODEL1310110045#_14438b44_677d_466b_8932_3946237e9dc3
type: Species
is encoded by: hsa:56606
initial concentration: NaN
has only substance units: false
initial amount: NaN
name: SLC2A9
is: SBO:0000252
constant: false
boundary condition: true

metaM 4nph c
constant: false
initial concentration: 1.0
is: HMDB01232
is: SBO:0000247
notes: FORMULA: C6H5NO3 CHARGE: 0 INCHI: InChI=1S/C6H5NO3/c8-6-3-1-5(2-4-6)7(9)10/h1-4,8H/p-1 HEPATONET_1.0_ABBREVIATION: HC00570 EHMN_ABBREVIATION: C00870
has only substance units: false
name: 4-nitrophenolate
is: CHEBI:57917
type: Species
boundary condition: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110045#_64ba01c4_cbc2_4a15_9475_2306fbdfd9c9
boundary condition: true
is: Q7GXY9
initial amount: NaN
constant: false
type: Species
initial concentration: NaN
is: SBO:0000252
has only substance units: false
name: ND2
is encoded by: hsa:4536

metaR GAL3ST12
product: MODEL1310110045#
is: SBO:0000176
fast: false
reversible: false
modifier: MODEL1310110045#
type: Reaction
notes: GENE_ASSOCIATION: (9514.1) SUBSYSTEM: Sphingolipid metabolism EC Number: 2.8.2.11 Confidence Level: 4 AUTHORS: PMID:9030544 NOTES:NJ
is version of: http://identifiers.org/ec-code/2.8.2.11
kinetic law: MODEL1310110045#
reactant: MODEL1310110045#
name: Galactosylceramide sulfotransferase
is described by: ECO:0000269

http://identifiers.org/biomodels.db/MODEL1310110045#_e68f1e03_312a_4e78_8807_832f2fabb9b0
boundary condition: true
constant: false
initial concentration: NaN
type: Species
is: SBO:0000252
is encoded by: hsa:5337
is: Q59EA4
name: PLD1
initial amount: NaN
has only substance units: false

metaR r0165
reactant: MODEL1310110045#
is: SBO:0000176
fast: false
name: UTP:pyruvate O2-phosphotransferase EC:2.7.1.40
is described by: ECO:0000000
modifier: MODEL1310110045#
type: Reaction
kinetic law: MODEL1310110045#
product: MODEL1310110045#
notes: GENE_ASSOCIATION: (6576.1) SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: 2.7.1.40 Confidence Level: 0 AUTHORS: PMID:1009117,PMID:7154942 NOTES:
reversible: false

metaR NADPtru
name: NADP transporter, endoplasmic reticulum
kinetic law: MODEL1310110045#
reversible: false
product: MODEL1310110045#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: NOTES:diffusion - but unidirectional output from ER (to avoid loops w/ NAD/NADP) NJ
type: Reaction
reactant: MODEL1310110045#
is: SBO:0000185
fast: false

metaR ALR3
kinetic law: MODEL1310110045#
modifier: MODEL1310110045#
reactant: MODEL1310110045#
reversible: false
is described by: ECO:0000269
is: SBO:0000176
fast: false
notes: GENE_ASSOCIATION: (10327.2) or (8574.1) or (10327.1) or (231.1) SUBSYSTEM: Pyruvate metabolism EC Number: 1.1.1.21 Confidence Level: 4 AUTHORS: PMID:12071861,PMID:1537826,PMID:9823300 NOTES:NCD
name: aldose reductase (acetol)
is version of: http://identifiers.org/ec-code/1.1.1.2
product: MODEL1310110045#
is version of: http://identifiers.org/ec-code/1.1.1.21
type: Reaction

metaR MMTSADm
kinetic law: MODEL1310110045#
fast: false
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: Confidence Level: 2 AUTHORS: PMID:1527093 NOTES:MM. biochemical activity measured in rat, sequence similarity found in human
reactant: MODEL1310110045#
is described by: ECO:0000000
is: SBO:0000176
name: malonate-semialdehyde dehydrogenase (acetylating), mitochondrial
reversible: false
product: MODEL1310110045#

metaR r0166
is: SBO:0000176
is described by: ECO:0000000
type: Reaction
kinetic law: MODEL1310110045#
reversible: false
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Pyrimidine catabolism EC Number: 3.6.1.19 Confidence Level: 0 AUTHORS: PMID:15652174,PMID:16752921,PMID:17095758 NOTES:
product: MODEL1310110045#
name: Uridine triphosphate pyrophosphohydrolase Pyrimidine metabolism EC:3.6.1.19
reactant: MODEL1310110045#

metaR r2097
kinetic law: MODEL1310110045#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
product: MODEL1310110045#
is described by: ECO:0000000
reversible: true
fast: false
is: SBO:0000185
type: Reaction
reactant: MODEL1310110045#
modifier: MODEL1310110045#

metaR H2Otm
modifier: MODEL1310110045#
type: Reaction
reversible: true
is described by: ECO:0000269
kinetic law: MODEL1310110045#
is: SBO:0000185
product: MODEL1310110045#
notes: GENE_ASSOCIATION: (343.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:15749715 NOTES:IF
reactant: MODEL1310110045#
name: H2O transport, mitochondrial
fast: false

metaM oaa c
is: HMDB00223
notes: FORMULA: C4H2O5 CHARGE: -2
is: CHEBI:3338
is: SBO:0000247
constant: false
type: Species
initial concentration: 1.0
is: C00036
has only substance units: false
initial amount: NaN
boundary condition: false
name: Oxaloacetate

metaM Tn antigen g
is: SBO:0000247
initial concentration: 1.0
is: C04383
boundary condition: false
notes: FORMULA: C8H14NO5X CHARGE: 0
constant: false
name: Tn antigen
type: Species
initial amount: NaN
has only substance units: false

metaM tdcoa x
is: HMDB01521
name: Tetradecanoyl-CoA (n-C14:0CoA)
is: SBO:0000247
constant: false
type: Species
is: C02593
is: CHEBI:57385
notes: FORMULA: C35H58N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00971 EHMN_ABBREVIATION: C02593
initial concentration: 1.0
has only substance units: false
initial amount: NaN
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110045#_cd81223c_f21a_42d0_85be_cf8e580d440f
type: Species
initial concentration: NaN
name: FASN
has only substance units: false
boundary condition: true
is: P49327
is encoded by: hsa:2194
is: SBO:0000252
constant: false
initial amount: NaN

metaR ILEt5m
reactant: MODEL1310110045#
fast: false
type: Reaction
is described by: ECO:0000000
is: SBO:0000185
kinetic law: MODEL1310110045#
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:11004451 NOTES:MM
name: Isoleucine mitochondrial transport
product: MODEL1310110045#

http://identifiers.org/biomodels.db/MODEL1310110045#_1d2e704f_854b_4733_b695_b9d59c9929ad
name: PROSC
is: O94903
initial concentration: NaN
has only substance units: false
boundary condition: true
is encoded by: hsa:11212
type: Species
is: SBO:0000252
constant: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110045#_5e87f735_93cf_4b83_8ad4_db1968cf6a3f
initial concentration: NaN
type: Species
constant: false
name: ACSL5
has only substance units: false
boundary condition: true
initial amount: NaN
is encoded by: hsa:51703
is: Q9ULC5
is: SBO:0000252

metaR DOLGPP Ler
is: SBO:0000176
product: MODEL1310110045#
kinetic law: MODEL1310110045#
reactant: MODEL1310110045#
is described by: ECO:0000000
reversible: false
name: Dolichyl-beta-D-glucosyl-phosphate dolichylphosphohydrolase (liver)
notes: GENE_ASSOCIATION: SUBSYSTEM: N-glycan synthesis EC Number: 3.1.4.48 Confidence Level: 0 AUTHORS: PMID:12137737 NOTES:
fast: false
type: Reaction

metaM s2l2n2m2mn l
type: Species
name: de-Fuc, reducing GlcNAc removed form of PA6 (w/o peptide linkage)
constant: false
initial amount: NaN
has only substance units: false
is: CHEBI:57312
is: HMDB01356
boundary condition: false
initial concentration: 1.0
notes: FORMULA: C76H123N5O57 CHARGE: -2
is: SBO:0000247

metaR r2098
is described by: ECO:0000000
reversible: true
reactant: MODEL1310110045#
kinetic law: MODEL1310110045#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
type: Reaction
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
product: MODEL1310110045#
modifier: MODEL1310110045#
fast: false
is: SBO:0000185

metaR NAt3 1
reversible: true
name: sodium proton antiporter (H:NA is 1:1)
type: Reaction
is described by: ECO:0000269
reactant: MODEL1310110045#
kinetic law: MODEL1310110045#
fast: false
is: SBO:0000185
modifier: MODEL1310110045#
product: MODEL1310110045#
notes: GENE_ASSOCIATION: (389015.1) or (6548.1) or (6550.1) or (6549.1) or (6553.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10444453,PMID:12845533,PMID:2536298,PMID:2581505,PMID:7631746,PMID:7759094,PMID:8199403,PMID:8595899,PMID:9933641 NOTES:JLR

metaR ALR2
type: Reaction
kinetic law: MODEL1310110045#
name: aldose reductase (methylglyoxal)
modifier: MODEL1310110045#
is version of: http://identifiers.org/ec-code/1.1.1.21
fast: false
is: SBO:0000176
reactant: MODEL1310110045#
is version of: http://identifiers.org/ec-code/1.1.1.2
product: MODEL1310110045#
notes: GENE_ASSOCIATION: (10327.2) or (8574.1) or (10327.1) or (231.1) SUBSYSTEM: Pyruvate metabolism EC Number: 1.1.1.21 Confidence Level: 4 AUTHORS: PMID:12071861,PMID:1537826,PMID:9823300 NOTES:NCD
is described by: ECO:0000269
reversible: false

metaM 3dhguln c
is: HMDB06334
has only substance units: false
initial amount: NaN
is: SBO:0000247
boundary condition: false
constant: false
type: Species
notes: FORMULA: C6H9O7 CHARGE: -1 INCHI: InChI=1S/C6H10O7/c7-1-2(8)3(9)4(10)5(11)6(12)13/h2-3,5,7-9,11H,1H2,(H,12,13)/p-1/t2-,3+,5-/m0/s1
initial concentration: 1.0
name: 3-dehydro-L-gulonate
is: CHEBI:57655

metaR H2Otn
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD
reversible: true
product: MODEL1310110045#
reactant: MODEL1310110045#
fast: false
is described by: ECO:0000000
name: H2O transport, nuclear
kinetic law: MODEL1310110045#
is: SBO:0000185

metaR GGH 7DHFl
notes: GENE_ASSOCIATION: (8836.1) SUBSYSTEM: Folate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:11375437,PMID:2867095,PMID:9614206 NOTES:REMOVES EITHER ONE OR TWO GLUTAMYL RESIDUES WITH A REACTION (WILL ONLY REPRESENT 1) IT
modifier: MODEL1310110045#
reactant: MODEL1310110045#
reversible: false
is version of: http://identifiers.org/ec-code/3.4.19.9
kinetic law: MODEL1310110045#
name: Gamma-glutamyl hydrolase (7DHF), lysosomal
type: Reaction
fast: false
is: SBO:0000176
is described by: ECO:0000000
product: MODEL1310110045#

metaM hexdicoa r
boundary condition: false
constant: false
initial concentration: 1.0
name: hexadecanedioylcoa
is: C08260
is: HMDB00672
type: Species
initial amount: NaN
is: SBO:0000247
notes: FORMULA: C37H59N7O19P3S CHARGE: -5
has only substance units: false

metaM thcholstoic x
type: Species
has only substance units: false
is: SBO:0000247
is: HMDB03873
notes: FORMULA: C27H45O5 CHARGE: -1 INCHI: InChI=1S/C27H46O5/c1-15(6-5-7-16(2)25(31)32)19-8-9-20-24-21(14-23(30)27(19,20)4)26(3)11-10-18(28)12-17(26)13-22(24)29/h15-24,28-30H,5-14H2,1-4H3,(H,31,32)/t15-,16?,17+,18-,19-,20+,21+,22-,23+,24+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01340 EHMN_ABBREVIATION: C04722
boundary condition: false
name: 3alpha,7alpha,12alpha-Trihydroxy-5beta-cholestanoate
initial amount: NaN
is: CHEBI:18402
constant: false
initial concentration: 1.0

metaR r1682
modifier: MODEL1310110045#
reactant: MODEL1310110045#
product: MODEL1310110045#
is: SBO:0000185
fast: false
kinetic law: MODEL1310110045#
is described by: ECO:0000000
reversible: false
type: Reaction
name: Y+LAT2 Utilized transport
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:

metaR FOLR2
is version of: http://identifiers.org/ec-code/1.5.1.3
kinetic law: MODEL1310110045#
product: MODEL1310110045#
name: folate reductase
is described by: ECO:0000254
is: SBO:0000176
modifier: MODEL1310110045#
reactant: MODEL1310110045#
type: Reaction
notes: GENE_ASSOCIATION: (1719.1) SUBSYSTEM: Folate metabolism EC Number: Confidence Level: 2 AUTHORS: NOTES:
reversible: false
fast: false

metaM betald c
initial amount: NaN
type: Species
has only substance units: false
boundary condition: false
name: betaine aldehyde
is: HMDB01252
initial concentration: 1.0
notes: FORMULA: C5H12NO CHARGE: 1 INCHI: InChI=1S/C5H12NO/c1-6(2,3)4-5-7/h5H,4H2,1-3H3/q+1 HEPATONET_1.0_ABBREVIATION: HC00435 EHMN_ABBREVIATION: C00576
constant: false
is: SBO:0000247
is: CHEBI:15710

metaR r2099
modifier: MODEL1310110045#
kinetic law: MODEL1310110045#
is described by: ECO:0000000
product: MODEL1310110045#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
is: SBO:0000185
fast: false
reversible: true
type: Reaction
reactant: MODEL1310110045#

metaM bilglcur e
notes: FORMULA: C39H44N4O12 CHARGE: 0 INCHI: InChI=1S/C39H44N4O12/c1-7-20-19(6)36(50)43-27(20)14-25-18(5)23(10-12-31(46)54-39-34(49)32(47)33(48)35(55-39)38(52)53)29(41-25)15-28-22(9-11-30(44)45)17(4)24(40-28)13-26-16(3)21(8-2)37(51)42-26/h7-8,13-14,32-35,39-41,47-49H,1-2,9-12,15H2,3-6H3,(H,42,51)(H,43,50)(H,44,45)(H,52,53)/p-2/b26-13+,27-14+/t32-,33-,34+,35-,39+/m0/s1 EHMN_ABBREVIATION: C03374
has only substance units: false
is: SBO:0000247
type: Species
constant: false
is: CHEBI:57767
initial concentration: 1.0
boundary condition: false
initial amount: NaN
name: mono(glucosyluronic acid)bilirubin(2-)

http://identifiers.org/biomodels.db/MODEL1310110045#_05e32aac_605c_4ce5_9b92_212b9e67d4af
is encoded by: hsa:8659
is: P30038
name: ALDH4A1
boundary condition: true
initial concentration: NaN
initial amount: NaN
type: Species
constant: false
has only substance units: false
is: SBO:0000252

metaM xoldiolone r
notes: FORMULA: C27H44O3 CHARGE: 0 INCHI: InChI=1S/C27H44O3/c1-16(2)7-6-8-17(3)20-9-10-21-25-22(15-24(30)27(20,21)5)26(4)12-11-19(28)13-18(26)14-23(25)29/h13,16-17,20-25,29-30H,6-12,14-15H2,1-5H3/t17-,20-,21+,22+,23-,24+,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01465 EHMN_ABBREVIATION: C05457
initial concentration: 1.0
is: CHEBI:28477
is: HMDB02197
name: 7alpha,12alpha-Dihydroxycholest-4-en-3-one
has only substance units: false
initial amount: NaN
constant: false
type: Species
is: SBO:0000247
boundary condition: false

metaR EX orn LPAREN e RPAREN
kinetic law: MODEL1310110045#
reactant: MODEL1310110045#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Ornithine exchange
type: Reaction

metaR GLYCLTtp
name: glycolate transport into peroxisome
kinetic law: MODEL1310110045#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: PMID:15240345 NOTES:NCD
fast: false
is: SBO:0000185
product: MODEL1310110045#
reactant: MODEL1310110045#
reversible: false
type: Reaction
is described by: ECO:0000000

metaR FUMtm
modifier: MODEL1310110045#
reactant: MODEL1310110045#
is described by: ECO:0000269
is: SBO:0000185
type: Reaction
notes: GENE_ASSOCIATION: (1468.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172,PMID:3587497 NOTES:TDV
fast: false
name: fumarate transport, mitochondrial
product: MODEL1310110045#
reversible: true
kinetic law: MODEL1310110045#

metaM dhor S c
name: (S)-dihydroorotate
notes: FORMULA: C5H5N2O4 CHARGE: -1 INCHI: InChI=1S/C5H6N2O4/c8-3-1-2(4(9)10)6-5(11)7-3/h2H,1H2,(H,9,10)(H2,6,7,8,11)/p-1/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00285
initial amount: NaN
constant: false
initial concentration: 1.0
is: HMDB03349
boundary condition: false
is: CHEBI:30864
type: Species
is: SBO:0000247
has only substance units: false

metaR HCO3 CLt
kinetic law: MODEL1310110045#
type: Reaction
reactant: MODEL1310110045#
is described by: ECO:0000269
fast: false
notes: GENE_ASSOCIATION: (6522.1) or (83697.1) or (6521.1) or (6508.2) or (6508.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:11302728,PMID:12027221,PMID:14722772 NOTES:MM
is: SBO:0000185
modifier: MODEL1310110045#
product: MODEL1310110045#
name: bicarbonate transport (Cl-/HCO3- exchange)
reversible: true

metaM CE2839 e
has only substance units: false
is: C01936
name: maltodecaose
boundary condition: false
is: http://identifiers.org/pubchem.compound/5041
constant: false
initial amount: NaN
type: Species
is: SBO:0000247
initial concentration: 1.0
notes: FORMULA: C60H102O51 CHARGE: 0 INCHI: InChI=1/C60H102O51/c61-1-11-21(71)22(72)33(83)52(94-11)104-43-13(3-63)96-54(35(85)24(43)74)106-45-15(5-65)98-56(37(87)26(45)76)108-47-17(7-67)100-58(39(89)28(47)78)110-49-19(9-69)102-60(41(91)30(49)80)111-50-20(10-70)101-59(40(90)31(50)81)109-48-18(8-68)99-57(38(88)29(48)79)107-46-16(6-66)97-55(36(86)27(46)77)105-44-14(4-64)95-53(34(84)25(44)75)103-42-12(2-62)93-51(92)32(82)23(42)73/h11-92H,1-10H2/t11-,12-,13-,14-,15-,16-,17-,18-,19-,20-,21+,22+,23-,24-,25-,26-,27-,28-,29-,30-,31-,32+,33+,34+,35+,36+,37+,38+,39+,40+,41+,42+,43+,44+,45+,46+,47+,48+,49+,50+,51u,52+,53+,54+,55+,56+,57+,58+,59+,60+/m1/s1 EHMN_ABBREVIATION: CE2839

http://identifiers.org/biomodels.db/MODEL1310110045#_fd963070_4fc6_4e55_9060_e120aab671cb
is encoded by: hsa:9926
is: SBO:0000252
boundary condition: true
has only substance units: false
type: Species
initial concentration: NaN
name: LPGAT1
constant: false
initial amount: NaN
is: Q92604

http://identifiers.org/biomodels.db/MODEL1310110045#_60a3b83f_0542_47f7_b2c0_9c5d9fde4aec
constant: false
type: Species
has only substance units: false
initial amount: NaN
is: O00483
is: SBO:0000252
is encoded by: hsa:4697
boundary condition: true
initial concentration: NaN
name: NDUFA4

metaM ksii core2 deg8 l
name: keratan sulfate II (core 2-linked), degradation product 8
is: CHEBI:12936
boundary condition: false
notes: FORMULA: C36H60N3O25X CHARGE: 0
constant: false
is: SBO:0000247
has only substance units: false
type: Species
initial amount: NaN
initial concentration: 1.0
is: HMDB00143

http://identifiers.org/biomodels.db/MODEL1310110045#_ecbf33ee_59f5_48ab_b696_a36dae14ea7e
is encoded by: hsa:8528
has only substance units: false
is: SBO:0000252
initial concentration: NaN
type: Species
name: DDO
constant: false
initial amount: NaN
is: Q99489
boundary condition: true

metaR H2Otp
reactant: MODEL1310110045#
reversible: true
product: MODEL1310110045#
fast: false
is described by: ECO:0000000
name: H2O transport, peroxisomal
is: SBO:0000185
type: Reaction
kinetic law: MODEL1310110045#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD

http://identifiers.org/biomodels.db/MODEL1310110045#_5a89039a_fa65_421a_8321_9eab5a95cf69
has only substance units: false
initial amount: NaN
boundary condition: true
constant: false
initial concentration: NaN
is: SBO:0000252
type: Species
is: P23634
name: ATP2B4
is encoded by: hsa:493

metaR SERGLNexR
reactant: MODEL1310110045#
reversible: true
fast: false
product: MODEL1310110045#
name: L-Serine/Glutamine reversible exchange
type: Reaction
modifier: MODEL1310110045#
notes: GENE_ASSOCIATION: (56301.1) and (6520.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10734121,PMID:10863037,PMID:14770310 NOTES:
is described by: ECO:0000304
is: SBO:0000185
kinetic law: MODEL1310110045#

metaR GALASE5ly
modifier: MODEL1310110045#
type: Reaction
fast: false
is version of: http://identifiers.org/ec-code/3.2.1.18
is: SBO:0000176
name: beta-galactosidase, lysosomal
is version of: http://identifiers.org/ec-code/3.2.1.23
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) or (5476.1) and (2720.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.23 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD
kinetic law: MODEL1310110045#
is version of: http://identifiers.org/ec-code/3.1.6.4
product: MODEL1310110045#
is version of: http://identifiers.org/ec-code/3.4.16.5
reactant: MODEL1310110045#
reversible: false
is described by: ECO:0000000

metaR THRD L
is described by: ECO:0000269
kinetic law: MODEL1310110045#
is: SBO:0000176
product: MODEL1310110045#
is version of: http://identifiers.org/ec-code/4.3.1.17
notes: GENE_ASSOCIATION: (10993.1) SUBSYSTEM: Glycine, serine, alanine and threonine metabolism EC Number: 4.3.1.19 Confidence Level: 4 AUTHORS: PMID:12361482 NOTES:Previous EC number: 4.2.1.16. New EC number 4.3.1.19. Can't enter this....
type: Reaction
fast: false
modifier: MODEL1310110045#
reactant: MODEL1310110045#
name: L-threonine deaminase
reversible: false

metaM dec47dicoa m
initial concentration: 1.0
notes: FORMULA: C31H46N7O17P3S CHARGE: -4
constant: false
initial amount: NaN
type: Species
boundary condition: false
has only substance units: false
is: http://identifiers.org/pubchem.compound/16019966
is: SBO:0000247
name: 4,7-decadienoylcoa

metaR G14T11g
kinetic law: MODEL1310110045#
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/2.4.1.22
product: MODEL1310110045#
is: SBO:0000176
type: Reaction
reactant: MODEL1310110045#
fast: false
is version of: http://identifiers.org/ec-code/2.4.1.90
modifier: MODEL1310110045#
reversible: false
name: beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase, Golgi
is version of: http://identifiers.org/ec-code/2.4.1.38
notes: GENE_ASSOCIATION: (8703.1) or (8704.2) or (8704.1) or (2683.1) or (9334.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.38 Confidence Level: 4 AUTHORS: PMID:12512857,PMID:1903938,PMID:3094506,PMID:3144273,PMID:9405390,PMID:9435216 NOTES:Keratan sulfate I biosynthesis NCD

http://identifiers.org/biomodels.db/MODEL1310110045#_a1db8599_fb5c_4c6d_b45a_e7f21b6350f8
constant: false
name: HGD
boundary condition: true
has only substance units: false
is: Q93099
type: Species
initial amount: NaN
is: SBO:0000252
initial concentration: NaN
is encoded by: hsa:3081

metaM arachdcoa x
is: CHEBI:57368
has only substance units: false
is: HMDB06523
initial concentration: 1.0
type: Species
constant: false
boundary condition: false
notes: FORMULA: C41H62N7O17P3S CHARGE: -4 INCHI: InChI=1S/C41H66N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-32(50)69-25-24-43-31(49)22-23-44-39(53)36(52)41(2,3)27-62-68(59,60)65-67(57,58)61-26-30-35(64-66(54,55)56)34(51)40(63-30)48-29-47-33-37(42)45-28-46-38(33)48/h8-9,11-12,14-15,17-18,28-30,34-36,40,51-52H,4-7,10,13,16,19-27H2,1-3H3,(H,43,49)(H,44,53)(H,57,58)(H,59,60)(H2,42,45,46)(H2,54,55,56)/p-4/b9-8-,12-11-,15-14-,18-17-/t30-,34-,35-,36+,40-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01986 EHMN_ABBREVIATION: C02249
is: SBO:0000247
name: arachidonoyl-CoA(4-)
initial amount: NaN

metaM ksi deg40 l
has only substance units: false
initial amount: NaN
is: HMDB00143
constant: false
name: keratan sulfate I, degradation product 40
initial concentration: 1.0
is: SBO:0000247
type: Species
notes: FORMULA: C40H68N2O31 CHARGE: 0
is: CHEBI:12936
boundary condition: false

metaM dece4coa m
is: HMDB02145
initial amount: NaN
is: SBO:0000247
name: 4-decenoylcoa
boundary condition: false
notes: FORMULA: C31H48N7O17P3S CHARGE: -4
initial concentration: 1.0
type: Species
constant: false
has only substance units: false

metaM bilglcur c
initial concentration: 1.0
has only substance units: false
is: CHEBI:57767
is: SBO:0000247
boundary condition: false
notes: FORMULA: C39H44N4O12 CHARGE: 0 INCHI: InChI=1S/C39H44N4O12/c1-7-20-19(6)36(50)43-27(20)14-25-18(5)23(10-12-31(46)54-39-34(49)32(47)33(48)35(55-39)38(52)53)29(41-25)15-28-22(9-11-30(44)45)17(4)24(40-28)13-26-16(3)21(8-2)37(51)42-26/h7-8,13-14,32-35,39-41,47-49H,1-2,9-12,15H2,3-6H3,(H,42,51)(H,43,50)(H,44,45)(H,52,53)/p-2/b26-13+,27-14+/t32-,33-,34+,35-,39+/m0/s1 EHMN_ABBREVIATION: C03374
initial amount: NaN
name: mono(glucosyluronic acid)bilirubin(2-)
constant: false
type: Species

metaM 2dr5p c
initial amount: NaN
initial concentration: 1.0
boundary condition: false
is: SBO:0000247
is: HMDB01031
notes: FORMULA: C5H9O7P CHARGE: -2 INCHI: InChI=1S/C5H11O7P/c6-2-1-4(7)5(8)3-12-13(9,10)11/h2,4-5,7-8H,1,3H2,(H2,9,10,11)/p-2/t4-,5+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00490 EHMN_ABBREVIATION: C00673
is: CHEBI:57651
has only substance units: false
constant: false
name: 2-deoxy-D-ribose 5-phosphate(2-)
type: Species

metaR r0926
name: Postulated transport reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:4358819 NOTES:
is described by: ECO:0000000
kinetic law: MODEL1310110045#
is: SBO:0000185
reactant: MODEL1310110045#
fast: false
product: MODEL1310110045#
reversible: false
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110045#_1477e619_40b6_4f4d_9d87_aad386b7dd49
is encoded by: hsa:48
is: P21399
initial concentration: NaN
constant: false
boundary condition: true
name: ACO1
type: Species
initial amount: NaN
is: SBO:0000252
has only substance units: false

metaR HAS2
type: Reaction
product: MODEL1310110045#
modifier: MODEL1310110045#
kinetic law: MODEL1310110045#
is version of: http://identifiers.org/ec-code/2.4.1.212
reversible: false
is: SBO:0000185
fast: false
notes: GENE_ASSOCIATION: (3038.2) or (3036.1) or (3038.1) or (3037.1) SUBSYSTEM: Hyaluronan metabolism EC Number: 2.4.1.212 Confidence Level: 4 AUTHORS: PMID:12512858,PMID:8651928,PMID:8798477,PMID:8798544,PMID:9083017 NOTES:NCD
name: hyaluronan synthase
is described by: ECO:0000269
reactant: MODEL1310110045#

http://identifiers.org/biomodels.db/MODEL1310110045#_d875be53_f98e_480e_b12f_70c9dfa131b5
has only substance units: false
name: _286297_1_c
initial concentration: NaN
boundary condition: true
is: SBO:0000252
constant: false
type: Species
initial amount: NaN
is encoded by: hsa:286297

metaM C05279 m
name: trans,cis-Lauro-2,6-dienoyl-CoA
notes: FORMULA: C33H50N7O17P3S CHARGE: -4 INCHI: InChI=1S/C33H54N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-24(42)61-17-16-35-23(41)14-15-36-31(45)28(44)33(2,3)19-54-60(51,52)57-59(49,50)53-18-22-27(56-58(46,47)48)26(43)32(55-22)40-21-39-25-29(34)37-20-38-30(25)40/h8-9,12-13,20-22,26-28,32,43-44H,4-7,10-11,14-19H2,1-3H3,(H,35,41)(H,36,45)(H,49,50)(H,51,52)(H2,34,37,38)(H2,46,47,48)/b9-8-,13-12+/t22-,26-,27-,28+,32-/m1/s1 EHMN_ABBREVIATION: C05279
initial amount: NaN
type: Species
initial concentration: 1.0
constant: false
is: HMDB11123
has only substance units: false
is: CHEBI:28387
is: SBO:0000247
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110045#_5f000fbf_1291_4669_899f_6402d5fb762c
initial concentration: NaN
is: SBO:0000252
name: GALNT4
type: Species
boundary condition: true
is: Q8N4A0
initial amount: NaN
has only substance units: false
constant: false
is encoded by: hsa:8693

metaM arg L c
name: L-argininium(1+)
constant: false
boundary condition: false
initial amount: NaN
initial concentration: 1.0
is: CHEBI:32682
has only substance units: false
type: Species
is: HMDB00517
notes: FORMULA: C6H15N4O2 CHARGE: 1 INCHI: InChI=1S/C6H14N4O2/c7-4(5(11)12)2-1-3-10-6(8)9/h4H,1-3,7H2,(H,11,12)(H4,8,9,10)/p+1/t4-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00065
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110045#_975d53b1_298a_4201_a741_30d1b94c1808
has only substance units: false
initial amount: NaN
is encoded by: hsa:4695
constant: false
is: SBO:0000252
initial concentration: NaN
name: NDUFA2
type: Species
is: O43678
boundary condition: true

metaR NACHEXA9ly
product: MODEL1310110045#
reversible: false
name: beta-N-acetylhexosaminidase A, lysosomal
type: Reaction
is: SBO:0000176
reactant: MODEL1310110045#
notes: GENE_ASSOCIATION: (3073.1) or (3073.1 and 3074.1) SUBSYSTEM: Keratan sulfate degradation EC Number: Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12706724,PMID:8993162 NOTES:Note that this reaction is specific to beta-N-acetylhexosaminidase A and cannot be catalyzed by beta-N-acetylhexosaminidase B (or presumably beta-N-acetylhexosaminidase S). This is also a lumped reaction, representing the cleavage of GalNAc4S or GalNAc6S and N-acetylgalactosamine 4-sulfatase or 6-sulfatase. NCD
fast: false
is described by: ECO:0000000
modifier: MODEL1310110045#
is version of: http://identifiers.org/ec-code/3.2.1.52
kinetic law: MODEL1310110045#

http://identifiers.org/biomodels.db/MODEL1310110045#_9af37fec_04c0_4e7d_9f07_272be020b4b2
constant: false
is: O95168
type: Species
has only substance units: false
boundary condition: true
is encoded by: hsa:4710
name: NDUFB4
initial concentration: NaN
initial amount: NaN
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110045#_655b39ea_6032_46e3_8458_168e7d4193e1
name: GPX7
is: SBO:0000252
initial amount: NaN
initial concentration: NaN
boundary condition: true
type: Species
is: Q96SL4
constant: false
has only substance units: false
is encoded by: hsa:2882

metaR TDCHOLAtx
is described by: ECO:0000000
kinetic law: MODEL1310110045#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: NOTES:unknown mechanism, however bile acids need to be secreted out of the cell NJ
is: SBO:0000185
reversible: true
name: bile acid intracellular transport
reactant: MODEL1310110045#
fast: false
type: Reaction
product: MODEL1310110045#

http://identifiers.org/biomodels.db/MODEL1310110045#_3427b37e_aee9_4302_a2ba_e218867226ff
is: SBO:0000252
is encoded by: hsa:4707
is: O75438
initial amount: NaN
has only substance units: false
initial concentration: NaN
constant: false
type: Species
boundary condition: true
name: NDUFB1

metaR DNDPt11m
fast: false
is: SBO:0000185
name: dADP transport via dGDP antiport
product: MODEL1310110045#
type: Reaction
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (60386.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:11226231 NOTES:IT
modifier: MODEL1310110045#
kinetic law: MODEL1310110045#
reactant: MODEL1310110045#
reversible: false

metaR LALDO
is version of: http://identifiers.org/ec-code/1.1.1.1
is described by: ECO:0000000
modifier: MODEL1310110045#
is: SBO:0000176
reactant: MODEL1310110045#
product: MODEL1310110045#
kinetic law: MODEL1310110045#
reversible: true
fast: false
name: D-Lactaldehyde:NAD+ oxidoreductase (glutathione-formylating)
notes: GENE_ASSOCIATION: (128.1) SUBSYSTEM: Pyruvate metabolism EC Number: 1.1.1.1 Confidence Level: 0 AUTHORS: NOTES:EC 1.2.1.1 NCD
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110045#_b02de54b_a5f3_45d0_8e4d_3960262fc4d5
initial concentration: NaN
is: SBO:0000252
initial amount: NaN
is: E9PEN2
name: MGAT4A
is encoded by: hsa:11320
constant: false
has only substance units: false
type: Species
boundary condition: true

metaR RE2999M
fast: false
product: MODEL1310110045#
modifier: MODEL1310110045#
is version of: http://identifiers.org/ec-code/1.1.1.35
notes: GENE_ASSOCIATION: (1632.1) or (10455.1) or (1962.1) SUBSYSTEM: Fatty acid oxidation EC Number: 5.3.3.8 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:7775433 NOTES:
name: RE2999
is described by: ECO:0000000
reactant: MODEL1310110045#
type: Reaction
reversible: true
is version of: http://identifiers.org/ec-code/5.3.3.8
kinetic law: MODEL1310110045#
is: SBO:0000176

metaR RE2659R
name: RE2659
notes: GENE_ASSOCIATION: SUBSYSTEM: Vitamin A metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:9647871 NOTES:
fast: false
reactant: MODEL1310110045#
is described by: ECO:0000000
kinetic law: MODEL1310110045#
is: SBO:0000176
reversible: true
product: MODEL1310110045#
type: Reaction

metaR r1685
reversible: false
fast: false
kinetic law: MODEL1310110045#
is: SBO:0000185
reactant: MODEL1310110045#
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
name: Y+LAT2 Utilized transport
product: MODEL1310110045#
is described by: ECO:0000000
type: Reaction
modifier: MODEL1310110045#

metaR DOPASULT
product: MODEL1310110045#
is version of: http://identifiers.org/ec-code/2.8.2.1
fast: false
modifier: MODEL1310110045#
notes: GENE_ASSOCIATION: (6799.1) or (6817.3) or (6799.2) or (6818.2) or (6817.2) or (6818.1) or (6817.1) or (6817.4) or (6818.3) or (6817.5) SUBSYSTEM: Tyrosine metabolism EC Number: 2.8.2.1 Confidence Level: 4 AUTHORS: PMID:11535246,PMID:15293241 NOTES:RS/TV (6/14/2005)
type: Reaction
reactant: MODEL1310110045#
reversible: false
name: Dopamine Sulfotransferase
kinetic law: MODEL1310110045#
is described by: ECO:0000269
is: SBO:0000176

metaM glx m
initial concentration: 1.0
notes: FORMULA: C2H1O3 CHARGE: -1 INCHI: InChI=1S/C2H2O3/c3-1-2(4)5/h1H,(H,4,5)/p-1 EHMN_ABBREVIATION: C00048
is: HMDB00119
is: CHEBI:36655
initial amount: NaN
name: glyoxylate
type: Species
has only substance units: false
boundary condition: false
constant: false
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110045#_ebfe71c0_4b29_49d9_a877_7b8d11a8abbe
constant: false
has only substance units: false
is: P13073
boundary condition: true
is: SBO:0000252
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:1327
name: COX4I1
type: Species

metaR GALASE8ly
modifier: MODEL1310110045#
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) or (5476.1) and (2720.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.23 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD
is version of: http://identifiers.org/ec-code/3.2.1.18
kinetic law: MODEL1310110045#
product: MODEL1310110045#
fast: false
reversible: false
is version of: http://identifiers.org/ec-code/3.1.6.4
is version of: http://identifiers.org/ec-code/3.4.16.5
is version of: http://identifiers.org/ec-code/3.2.1.23
is: SBO:0000176
name: beta-galactosidase, lysosomal
type: Reaction
is described by: ECO:0000000
reactant: MODEL1310110045#

metaM CE5786 e
notes: FORMULA: C56H87N17O11 CHARGE: 2 INCHI: InChI=1/C56H85N17O11/c1-6-32(4)45(57)52(81)66-33(5)46(75)67-38(15-10-22-63-55(58)59)47(76)68-39(16-11-23-64-56(60)61)48(77)71-42(28-36-29-62-30-65-36)53(82)73-24-12-17-44(73)51(80)70-41(27-35-18-20-37(74)21-19-35)49(78)69-40(26-34-13-8-7-9-14-34)50(79)72-43(54(83)84)25-31(2)3/h7-9,13-14,18-21,29-33,38-45,74H,6,10-12,15-17,22-28,57H2,1-5H3,(H,62,65)(H,66,81)(H,67,75)(H,68,76)(H,69,78)(H,70,80)(H,71,77)(H,72,79)(H,83,84)(H4,58,59,63)(H4,60,61,64)/p+2/t32-,33+,38-,39+,40-,41+,42-,43+,44-,45-/m1/s1 EHMN_ABBREVIATION: CE5786
is: SBO:0000247
boundary condition: false
type: Species
is: HMDB02710
name: kinetensin
initial concentration: 1.0
constant: false
is: CHEBI:27485
has only substance units: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110045#_94487727_9737_42fe_974b_16606a3386c4
is encoded by: hsa:83715
initial concentration: NaN
type: Species
is: SBO:0000252
initial amount: NaN
has only substance units: false
constant: false
is: B1AK53
boundary condition: true
name: ESPN

http://identifiers.org/biomodels.db/MODEL1310110045#_82588223_a054_4d98_afbe_f895cab637bd
name: ESCO2
initial amount: NaN
constant: false
type: Species
is: SBO:0000252
is: Q56NI9
boundary condition: true
initial concentration: NaN
has only substance units: false
is encoded by: hsa:157570

metaM dtdp m
notes: FORMULA: C10H13N2O11P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00307 EHMN_ABBREVIATION: C00363
is: CHEBI:58369
constant: false
boundary condition: false
type: Species
is: SBO:0000247
initial amount: NaN
has only substance units: false
name: dTDP
initial concentration: 1.0
is: C00363
is: HMDB01274

metaM C02528 c
is: HMDB00518
initial amount: NaN
is: SBO:0000247
is: CHEBI:36234
boundary condition: false
initial concentration: 1.0
name: chenodeoxycholate
type: Species
notes: FORMULA: C24H39O4 CHARGE: -1 INCHI: InChI=1S/C24H40O4/c1-14(4-7-21(27)28)17-5-6-18-22-19(9-11-24(17,18)3)23(2)10-8-16(25)12-15(23)13-20(22)26/h14-20,22,25-26H,4-13H2,1-3H3,(H,27,28)/p-1/t14-,15+,16-,17-,18+,19+,20-,22+,23+,24-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00958 EHMN_ABBREVIATION: C02528
constant: false
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110045#_12cb52f6_4998_4d79_8d71_9dfa32fd818f
boundary condition: true
is: SBO:0000252
initial concentration: NaN
has only substance units: false
name: _AI924226_1_m
type: Species
is encoded by: hsa:AI924226
initial amount: NaN
constant: false

metaR BPNT
product: MODEL1310110045#
notes: GENE_ASSOCIATION: (10380.1) SUBSYSTEM: Nucleotide interconversion EC Number: 3.1.3.7 Confidence Level: 4 AUTHORS: PMID:10224133 NOTES:
reactant: MODEL1310110045#
is: SBO:0000176
name: 3',5'-bisphosphate nucleotidase
kinetic law: MODEL1310110045#
type: Reaction
is described by: ECO:0000269
modifier: MODEL1310110045#
is version of: http://identifiers.org/ec-code/3.1.3.7
reversible: false
fast: false

metaM dag hs c
boundary condition: false
initial amount: NaN
is: SBO:0000247
name: diglyceride
has only substance units: false
is: CHEBI:18035
notes: FORMULA: C3H6OFULLRCO2FULLR2CO2 CHARGE: 0
initial concentration: 1.0
type: Species
constant: false

http://identifiers.org/biomodels.db/MODEL1310110045#_ef0d5064_8722_43df_9ec4_c4c8fb3d4d16
has only substance units: false
is: P50747
initial concentration: NaN
is encoded by: hsa:3141
type: Species
name: HLCS
initial amount: NaN
boundary condition: true
constant: false
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110045#_e0acec9e_21bd_49d3_86ef_22a67f9a011f
constant: false
type: Species
initial amount: NaN
boundary condition: true
is: P14672
name: SLC2A4
is: SBO:0000252
has only substance units: false
initial concentration: NaN
is encoded by: hsa:6517

http://identifiers.org/biomodels.db/MODEL1310110045#_3d9f42fb_ef5b_49fd_9f65_7c2d87171340
has only substance units: false
initial amount: NaN
name: AADAT
boundary condition: true
type: Species
is: SBO:0000252
constant: false
is: Q4W5N8
initial concentration: NaN
is encoded by: hsa:51166

metaR RETHe
type: Reaction
reactant: MODEL1310110045#
product: MODEL1310110045#
reversible: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Vitamin A metabolism EC Number: Confidence Level: 2 AUTHORS: PMID:1503811 NOTES:IT
kinetic law: MODEL1310110045#
is: SBO:0000176
fast: false
name: retinyl ester hydrolase, extracellular
is described by: ECO:0000000

metaR CITRtm
name: citrulline mitochondrial transport via proton antiport
product: MODEL1310110045#
reactant: MODEL1310110045#
modifier: MODEL1310110045#
is described by: ECO:0000269
type: Reaction
reversible: true
fast: false
is: SBO:0000185
kinetic law: MODEL1310110045#
notes: GENE_ASSOCIATION: (83884.1) or (10166.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172 NOTES:TDV

metaR GGH 5DHFl
reversible: false
type: Reaction
reactant: MODEL1310110045#
fast: false
modifier: MODEL1310110045#
name: Gamma-glutamyl hydrolase (5DHF), lysosomal
is: SBO:0000176
notes: GENE_ASSOCIATION: (8836.1) SUBSYSTEM: Folate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:11375437,PMID:2867095,PMID:9614206 NOTES:REMOVES EITHER ONE OR TWO GLUTAMYL RESIDUES WITH A REACTION (WILL ONLY REPRESENT 1) - last step from 5-glutamyl to monoglutamyl is in one step IT
is version of: http://identifiers.org/ec-code/3.4.19.9
product: MODEL1310110045#
is described by: ECO:0000000
kinetic law: MODEL1310110045#

metaM ethamp c
initial concentration: 1.0
constant: false
is: CHEBI:58190
name: ethamp[c]
has only substance units: false
initial amount: NaN
notes: FORMULA: C2H7NO4P CHARGE: -1 INCHI: InChI=1S/C2H8NO4P/c3-1-2-7-8(4,5)6/h1-3H2,(H2,4,5,6)/p-1 HEPATONET_1.0_ABBREVIATION: HC00293 EHMN_ABBREVIATION: C00346
boundary condition: false
is: HMDB00224
is: SBO:0000247
type: Species

metaR EX ksi LPAREN e RPAREN
kinetic law: MODEL1310110045#
reactant: MODEL1310110045#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: keratan sulfate I exchange
type: Reaction

metaR H2Otg
reversible: true
fast: false
name: H2O transport, Golgi apparatus
type: Reaction
reactant: MODEL1310110045#
kinetic law: MODEL1310110045#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD
is described by: ECO:0000000
product: MODEL1310110045#

metaR ARACHDCOAtx
reversible: true
name: fatty acid intracellular transport
kinetic law: MODEL1310110045#
type: Reaction
reactant: MODEL1310110045#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: NOTES:interaction between peroxisomes and ER (some enzymes on the outer membrane) NJ
fast: false
product: MODEL1310110045#
is: SBO:0000185

metaR CERT2rt
is: SBO:0000185
is described by: ECO:0000000
type: Reaction
modifier: MODEL1310110045#
reactant: MODEL1310110045#
product: MODEL1310110045#
reversible: true
name: ceramide transport protein
notes: GENE_ASSOCIATION: (10087.1) SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: PMID:12803919,PMID:14685229,PMID:15596449,PMID:15907394 NOTES:non-vesicular intracellular transport of glucocerebroside
fast: false
kinetic law: MODEL1310110045#
is version of: http://identifiers.org/ec-code/2.7.11.1

metaR EX rbt LPAREN e RPAREN
kinetic law: MODEL1310110045#
reactant: MODEL1310110045#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Ribitol exchange
type: Reaction

metaM oh1 c
is: C01328
is: SBO:0000247
type: Species
notes: FORMULA: HO CHARGE: -1
name: hydroxide ion
is: HMDB01039
boundary condition: false
constant: false
has only substance units: false
initial amount: NaN
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110045#_062aa70d_2905_47c0_87d8_4297866b896d
boundary condition: true
is: Q13946
has only substance units: false
is: SBO:0000252
initial amount: NaN
type: Species
is encoded by: hsa:5150
constant: false
initial concentration: NaN
name: PDE7A

metaM 3hpp m
type: Species
name: 3-hydroxypropionate
initial amount: NaN
initial concentration: 1.0
has only substance units: false
boundary condition: false
constant: false
is: HMDB00700
is: CHEBI:16510
is: SBO:0000247
notes: FORMULA: C3H5O3 CHARGE: -1 INCHI: InChI=1S/C3H6O3/c4-2-1-3(5)6/h4H,1-2H2,(H,5,6)/p-1 HEPATONET_1.0_ABBREVIATION: HC00625 EHMN_ABBREVIATION: C01013

metaM ksii core2 pre5 g
is: HMDB00175
initial concentration: 1.0
name: keratan sulfate II biosynthesis, precursor 5
constant: false
is: C00130
notes: FORMULA: C61H99N5O43X CHARGE: -1
is: SBO:0000247
type: Species
is: CHEBI:58053
has only substance units: false
initial amount: NaN
boundary condition: false

metaR PSDm hs
modifier: MODEL1310110045#
reactant: MODEL1310110045#
product: MODEL1310110045#
notes: GENE_ASSOCIATION: (23761.1) SUBSYSTEM: Glycerophospholipid metabolism EC Number: 4.1.1.65 Confidence Level: 4 AUTHORS: PMID:15052331,PMID:9370338 NOTES:modified from TV version for hs NJ
kinetic law: MODEL1310110045#
reversible: false
name: Phosphatidylserine decarboxylase
is version of: http://identifiers.org/ec-code/4.1.1.65
is: SBO:0000176
type: Reaction
is described by: ECO:0000269
fast: false

metaR GLCNACPT L
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.7.8.15
kinetic law: MODEL1310110045#
is described by: ECO:0000000
fast: false
type: Reaction
product: MODEL1310110045#
reactant: MODEL1310110045#
name: UDP-GlcNAc:dolichol-phosphate GlcNAc phosphotransferase (liver)
modifier: MODEL1310110045#
notes: GENE_ASSOCIATION: (1798.1) or (1798.2) SUBSYSTEM: N-glycan synthesis EC Number: 2.7.8.15 Confidence Level: 0 AUTHORS: NOTES:NCD
reversible: false

metaR THCHOLSTOICtm
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: PMID:12840657 NOTES:cholesterol precursor, transport by "diffusion" -> actually beleived to be flip-flop mechanism (PMID: 12840657). NJ
is described by: ECO:0000000
name: lipid, flip-flop intracellular transport
fast: false
reversible: true
reactant: MODEL1310110045#
product: MODEL1310110045#
is: SBO:0000185
kinetic law: MODEL1310110045#

metaM oaa m
notes: FORMULA: C4H2O5 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00044 EHMN_ABBREVIATION: C00036
is: SBO:0000247
is: CHEBI:16452
is: C00036
initial concentration: 1.0
initial amount: NaN
has only substance units: false
constant: false
name: Oxaloacetate
boundary condition: false
type: Species
is: HMDB00223

metaM pacald c
initial concentration: 1.0
is: SBO:0000247
name: phenylacetaldehyde
notes: FORMULA: C8H8O CHARGE: 0 INCHI: InChI=1S/C8H8O/c9-7-6-8-4-2-1-3-5-8/h1-5,7H,6H2 HEPATONET_1.0_ABBREVIATION: HC00448 EHMN_ABBREVIATION: C00601
boundary condition: false
is: CHEBI:16424
has only substance units: false
initial amount: NaN
type: Species
is: HMDB06236
constant: false

metaR PIK3
is version of: http://identifiers.org/ec-code/2.7.1.154
reversible: false
modifier: MODEL1310110045#
is version of: http://identifiers.org/ec-code/2.7.1.137
is version of: http://identifiers.org/ec-code/2.7.11.1
reactant: MODEL1310110045#
is version of: http://identifiers.org/ec-code/2.7.1.153
is described by: ECO:0000000
type: Reaction
is: SBO:0000176
notes: GENE_ASSOCIATION: (5295.2 and 5291.1) or (23533.1 and 5294.1) or (5290.1 and 5295.1) or (5293.1 and 5295.3) or (5287.1) or (5286.1) or (5293.1 and 5296.1) or (5295.2 and 5293.1) or (5296.1 and 5291.1) or (5290.1 and 5295.3) or (5288.1) or (5290.1 and 8503.1) or (5291.1 and 5295.3) or (10870.1 and 5294.1) or (5291.1 and 8503.1) or (5293.1 and 5295.1) or (5296.1 and 5290.1) or (5289.1) or (5293.1 and 8503.1) or (5291.1 and 5295.1) or (5295.2 and 5290.1) SUBSYSTEM: Inositol phosphate metabolism EC Number: 2.7.1.137 Confidence Level: 4 AUTHORS: PMID:7624799,PMID:7628435,PMID:7713498,PMID:8246984,PMID:9113989,PMID:9337861,PMID:9830063,PMID:9878262 NOTES:NCD
kinetic law: MODEL1310110045#
fast: false
product: MODEL1310110045#
name: phosphatidylinositol 3-kinase

metaM ppa c
is: SBO:0000247
is: CHEBI:17272
has only substance units: false
name: propionate
notes: FORMULA: C3H5O2 CHARGE: -1 INCHI: InChI=1S/C3H6O2/c1-2-3(4)5/h2H2,1H3,(H,4,5)/p-1 HEPATONET_1.0_ABBREVIATION: HC00158 EHMN_ABBREVIATION: C00163
constant: false
initial concentration: 1.0
boundary condition: false
type: Species
initial amount: NaN
is: HMDB00237

metaM duri n
initial concentration: 1.0
has only substance units: false
is: HMDB00012
name: 2'-deoxyuridine
notes: FORMULA: C9H12N2O5 CHARGE: 0 INCHI: InChI=1S/C9H12N2O5/c12-4-6-5(13)3-8(16-6)11-2-1-7(14)10-9(11)15/h1-2,5-6,8,12-13H,3-4H2,(H,10,14,15)/t5-,6+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00410 EHMN_ABBREVIATION: C00526
constant: false
initial amount: NaN
is: SBO:0000247
boundary condition: false
type: Species
is: CHEBI:16450

metaM lys L x
is: CHEBI:32551
is: SBO:0000247
type: Species
is: HMDB00182
initial concentration: 1.0
notes: FORMULA: C6H15N2O2 CHARGE: 1 INCHI: InChI=1S/C6H14N2O2/c7-4-2-1-3-5(8)6(9)10/h5H,1-4,7-8H2,(H,9,10)/p+1/t5-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00053 EHMN_ABBREVIATION: C00047
name: L-lysinium(1+)
boundary condition: false
has only substance units: false
constant: false
initial amount: NaN

metaM C02528 e
boundary condition: false
type: Species
constant: false
name: chenodeoxycholate
is: CHEBI:36234
is: SBO:0000247
notes: FORMULA: C24H39O4 CHARGE: -1 INCHI: InChI=1S/C24H40O4/c1-14(4-7-21(27)28)17-5-6-18-22-19(9-11-24(17,18)3)23(2)10-8-16(25)12-15(23)13-20(22)26/h14-20,22,25-26H,4-13H2,1-3H3,(H,27,28)/p-1/t14-,15+,16-,17-,18+,19+,20-,22+,23+,24-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00958 EHMN_ABBREVIATION: C02528
initial concentration: 1.0
has only substance units: false
is: HMDB00518
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110045#_470e99e2_5f13_42ca_adfb_3acb10cb8bc4
has only substance units: false
is encoded by: hsa:6005
constant: false
type: Species
boundary condition: true
name: RHAG
initial concentration: NaN
initial amount: NaN
is: Q96E98
is: SBO:0000252

metaR NACHEX21ly
product: MODEL1310110045#
reactant: MODEL1310110045#
fast: false
notes: GENE_ASSOCIATION: (3074.1) or (3073.1) or (3073.1 and 3074.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.52 Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12706724,PMID:8993162 NOTES:NCD
kinetic law: MODEL1310110045#
modifier: MODEL1310110045#
reversible: false
is described by: ECO:0000000
type: Reaction
is: SBO:0000176
name: beta-N-acetylhexosaminidase, lysosomal
is version of: http://identifiers.org/ec-code/3.2.1.52

http://identifiers.org/biomodels.db/MODEL1310110045#_5f00f95e_2d4a_4d0a_9f69_0362227d8762
is: SBO:0000252
has only substance units: false
is encoded by: hsa:64064
initial amount: NaN
initial concentration: NaN
is: Q9BYC2
boundary condition: true
constant: false
name: OXCT2
type: Species

http://identifiers.org/biomodels.db/MODEL1310110045#_9226410e_823e_4fb1_9e9f_2cfa4d4f2119
is encoded by: hsa:10195
has only substance units: false
name: ALG3
constant: false
initial amount: NaN
type: Species
boundary condition: true
is: SBO:0000252
initial concentration: NaN

metaR PRPPS
reactant: MODEL1310110045#
is described by: ECO:0000000
fast: false
is version of: http://identifiers.org/ec-code/2.7.6.1
kinetic law: MODEL1310110045#
is: SBO:0000176
modifier: MODEL1310110045#
product: MODEL1310110045#
name: phosphoribosylpyrophosphate synthetase
notes: GENE_ASSOCIATION: (221823.2) or (5631.1) or (221823.1) or (5634.1) SUBSYSTEM: Pentose phosphate pathway EC Number: Confidence Level: 0 AUTHORS: NOTES:
type: Reaction
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110045#_edaf593d_6248_46ac_acc4_a136ff544bb8
constant: false
initial amount: NaN
name: PRDX1
is: SBO:0000252
type: Species
boundary condition: true
is encoded by: hsa:5052
initial concentration: NaN
has only substance units: false

metaM dtdp n
notes: FORMULA: C10H13N2O11P2 CHARGE: -3 INCHI: InChI=1S/C10H16N2O11P2/c1-5-3-12(10(15)11-9(5)14)8-2-6(13)7(22-8)4-21-25(19,20)23-24(16,17)18/h3,6-8,13H,2,4H2,1H3,(H,19,20)(H,11,14,15)(H2,16,17,18)/p-3/t6-,7+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00307 EHMN_ABBREVIATION: C00363
is: SBO:0000247
type: Species
is: HMDB01274
is: CHEBI:58369
initial concentration: 1.0
has only substance units: false
initial amount: NaN
name: ({[(2R,3S,5R)-3-hydroxy-5-(5-methyl-2,4-dioxo-1,2,3,4-tetrahydropyrimidin-1-yl)oxolan-2-yl]methyl phosphonato}oxy)phosphonate
boundary condition: false
constant: false

metaM oxa c
constant: false
initial amount: NaN
notes: FORMULA: C2O4 CHARGE: -2 INCHI: InChI=1S/C2H2O4/c3-1(4)2(5)6/h(H,3,4)(H,5,6)/p-2 HEPATONET_1.0_ABBREVIATION: HC00195 EHMN_ABBREVIATION: C00209
type: Species
initial concentration: 1.0
has only substance units: false
name: oxalate(2-)
is: SBO:0000247
boundary condition: false
is: HMDB02329
is: CHEBI:30623

http://identifiers.org/biomodels.db/MODEL1310110045#_6b8da7e7_74f0_461b_bd9e_3d00fb9c729f
type: Species
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:4724
is: O43181
has only substance units: false
initial concentration: NaN
constant: false
boundary condition: true
name: NDUFS4

metaM dgmp e
initial concentration: 1.0
initial amount: NaN
has only substance units: false
type: Species
is: CHEBI:57673
constant: false
is: HMDB01044
is: SBO:0000247
notes: FORMULA: C10H12N5O7P CHARGE: -2 INCHI: InChI=1S/C10H14N5O7P/c11-10-13-8-7(9(17)14-10)12-3-15(8)6-1-4(16)5(22-6)2-21-23(18,19)20/h3-6,16H,1-2H2,(H2,18,19,20)(H3,11,13,14,17)/p-2/t4-,5+,6+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00306 EHMN_ABBREVIATION: C00362
boundary condition: false
name: dGMP(2-)

metaR r2018
modifier: MODEL1310110045#
reversible: false
is described by: ECO:0000000
fast: false
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
type: Reaction
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.15
kinetic law: MODEL1310110045#
is: SBO:0000185
product: MODEL1310110045#
reactant: MODEL1310110045#

metaM arachdcoa c
is: CHEBI:57368
type: Species
is: HMDB06523
has only substance units: false
is: SBO:0000247
constant: false
boundary condition: false
initial concentration: 1.0
notes: FORMULA: C41H62N7O17P3S CHARGE: -4 INCHI: InChI=1S/C41H66N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-32(50)69-25-24-43-31(49)22-23-44-39(53)36(52)41(2,3)27-62-68(59,60)65-67(57,58)61-26-30-35(64-66(54,55)56)34(51)40(63-30)48-29-47-33-37(42)45-28-46-38(33)48/h8-9,11-12,14-15,17-18,28-30,34-36,40,51-52H,4-7,10,13,16,19-27H2,1-3H3,(H,43,49)(H,44,53)(H,57,58)(H,59,60)(H2,42,45,46)(H2,54,55,56)/p-4/b9-8-,12-11-,15-14-,18-17-/t30-,34-,35-,36+,40-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01986 EHMN_ABBREVIATION: C02249
initial amount: NaN
name: arachidonoyl-CoA(4-)

http://identifiers.org/biomodels.db/MODEL1310110045#_24485f2a_ddb6_4c41_ad3a_03c5813c354c
constant: false
is: Q9Y3Y1
boundary condition: true
initial amount: NaN
is encoded by: hsa:65010
type: Species
name: SLC26A6
is: SBO:0000252
has only substance units: false
initial concentration: NaN

metaR MI145PK
is: SBO:0000176
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (3706.1) or (80271.1) or (3707.1) SUBSYSTEM: Inositol phosphate metabolism EC Number: 2.7.1.127 Confidence Level: 4 AUTHORS: PMID:11085927,PMID:1654894,PMID:2906139 NOTES:NCD
product: MODEL1310110045#
type: Reaction
modifier: MODEL1310110045#
kinetic law: MODEL1310110045#
fast: false
name: inositol-1,4,5-trisphosphate 3-kinase
is version of: http://identifiers.org/ec-code/2.7.1.127
reversible: false
reactant: MODEL1310110045#

http://identifiers.org/biomodels.db/MODEL1310110045#_092d99c7_e605_41db_857f_3eef74d390d5
has only substance units: false
initial concentration: NaN
is: SBO:0000252
initial amount: NaN
name: VNN3
boundary condition: true
type: Species
is encoded by: hsa:55350
constant: false

http://identifiers.org/biomodels.db/MODEL1310110045#_4eac1d6b_fb9c_4e72_9cda_49aaea65c7dc
name: ACP2
boundary condition: true
initial amount: NaN
is: SBO:0000252
is encoded by: hsa:53
type: Species
constant: false
initial concentration: NaN
is: E9PCI1
has only substance units: false

metaM ksi pre4 g
type: Species
boundary condition: false
has only substance units: false
notes: FORMULA: C101H165N7O72X CHARGE: -1
constant: false
is: SBO:0000247
name: keratan sulfate I biosynthesis, precursor 4
is: HMDB00175
is: C00130
initial concentration: 1.0
is: CHEBI:58053
initial amount: NaN

metaR PHEACGLNt
kinetic law: MODEL1310110045#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14681857 NOTES:SAB
reactant: MODEL1310110045#
reversible: true
fast: false
name: PHEACGLN extracellular transport via diffusion
product: MODEL1310110045#
is: SBO:0000185
type: Reaction
is described by: ECO:0000000

metaM acgam r
is: HMDB00215
has only substance units: false
is: SBO:0000247
name: N-acetyl-D-glucosamine
is: CHEBI:17411
notes: FORMULA: C8H15NO6 CHARGE: 0 INCHI: InChI=1S/C8H15NO6/c1-4(12)9-5(2-10)7(14)8(15)6(13)3-11/h2,5-8,11,13-15H,3H2,1H3,(H,9,12)/t5-,6+,7+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00138 EHMN_ABBREVIATION: C00140
boundary condition: false
initial amount: NaN
initial concentration: 1.0
constant: false
type: Species

metaM amet c
is: CHEBI:15414
is: C00019
has only substance units: false
initial amount: NaN
initial concentration: 1.0
type: Species
is: SBO:0000247
is: HMDB01185
boundary condition: false
constant: false
notes: FORMULA: C15H23N6O5S CHARGE: 1 HEPATONET_1.0_ABBREVIATION: HC00029 EHMN_ABBREVIATION: C00019
name: S-Adenosyl-L-methionine

metaM pmtcrn c
type: Species
boundary condition: false
name: L-palmitoylcarnitine
is: CHEBI:17490
has only substance units: false
notes: FORMULA: C23H45NO4 CHARGE: 0 INCHI: InChI=1S/C23H45NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-23(27)28-21(19-22(25)26)20-24(2,3)4/h21H,5-20H2,1-4H3/t21-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01034 EHMN_ABBREVIATION: C02990
initial concentration: 1.0
is: SBO:0000247
is: HMDB00222
initial amount: NaN
constant: false

metaR SMPD4
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Sphingolipid metabolism EC Number: Confidence Level: 2 AUTHORS: PMID:12069827,PMID:9972865 NOTES:reaction details not determined - elucidated from PMID: 9972865, 12069827 NJ
kinetic law: MODEL1310110045#
reversible: false
is described by: ECO:0000000
product: MODEL1310110045#
reactant: MODEL1310110045#
type: Reaction
fast: false
name: sphingomyelinase

metaR COAtr
kinetic law: MODEL1310110045#
reversible: true
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: NOTES:diffusion NJ
type: Reaction
is: SBO:0000185
is described by: ECO:0000000
product: MODEL1310110045#
reactant: MODEL1310110045#
name: COA transporter, endoplasmic reticulum

metaR LYStn
type: Reaction
is: SBO:0000185
product: MODEL1310110045#
fast: false
is described by: ECO:0000000
name: L-lysine transport, nuclear
kinetic law: MODEL1310110045#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: NOTES:IT
reversible: true
reactant: MODEL1310110045#

metaR MG2er
name: mannosyl-oligosaccharide glucosidase, endoplasmic reticulum
is described by: ECO:0000000
type: Reaction
fast: false
reactant: MODEL1310110045#
product: MODEL1310110045#
reversible: false
kinetic law: MODEL1310110045#
notes: GENE_ASSOCIATION: SUBSYSTEM: N-glycan synthesis EC Number: Confidence Level: 0 AUTHORS: NOTES:EC-3.2.1.- NCD
is: SBO:0000176

metaR UGLCNACtg
product: MODEL1310110045#
notes: GENE_ASSOCIATION: (11046.1) SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 4 AUTHORS: PMID:15082721,PMID:15607426 NOTES:NCD
fast: false
is described by: ECO:0000269
modifier: MODEL1310110045#
name: UDP-GlcNAc Golgi transport via CMP antiport
is: SBO:0000185
reactant: MODEL1310110045#
type: Reaction
reversible: true
kinetic law: MODEL1310110045#

metaM oxa e
is: CHEBI:30623
name: oxalate(2-)
is: SBO:0000247
has only substance units: false
notes: FORMULA: C2O4 CHARGE: -2 INCHI: InChI=1S/C2H2O4/c3-1(4)2(5)6/h(H,3,4)(H,5,6)/p-2 HEPATONET_1.0_ABBREVIATION: HC00195 EHMN_ABBREVIATION: C00209
initial concentration: 1.0
is: HMDB02329
boundary condition: false
constant: false
initial amount: NaN
type: Species

http://identifiers.org/biomodels.db/MODEL1310110045#_65db8001_9f79_4abb_aec1_f832adc5c804
is encoded by: hsa:3795
name: KHK
has only substance units: false
type: Species
is: SBO:0000252
is: P50053
initial amount: NaN
initial concentration: NaN
boundary condition: true
constant: false

http://identifiers.org/biomodels.db/MODEL1310110045#_3fe11e4c_729d_4b0c_b1f6_9120e27843d4
is encoded by: hsa:4668
is: P17050
has only substance units: false
type: Species
boundary condition: true
constant: false
is: SBO:0000252
initial amount: NaN
name: NAGA
initial concentration: NaN

metaM ser L c
initial concentration: 1.0
boundary condition: false
initial amount: NaN
is: CHEBI:17115
constant: false
name: L-serine
type: Species
notes: FORMULA: C3H7NO3 CHARGE: 0 INCHI: InChI=1S/C3H7NO3/c4-2(1-5)3(6)7/h2,5H,1,4H2,(H,6,7)/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00068
is: HMDB00187
is: SBO:0000247
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110045#_27af5fde_ab46_480f_99a7_96e8d31897a3
type: Species
boundary condition: true
is: SBO:0000252
has only substance units: false
constant: false
is encoded by: hsa:7296
initial concentration: NaN
name: TXNRD1
initial amount: NaN

metaR Coqe
reactant: MODEL1310110045#
type: Reaction
kinetic law: MODEL1310110045#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
fast: false
product: MODEL1310110045#
is: SBO:0000185
name: Transport of q10
reversible: true

metaR r1008
name: Facilitated diffusion
fast: false
is: SBO:0000185
is described by: ECO:0000000
reactant: MODEL1310110045#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:1735445,PMID:18406340,PMID:1988962,PMID:2351134,PMID:2355017,PMID:6361812,PMID:7892212,PMID:8132483 NOTES:
reversible: false
kinetic law: MODEL1310110045#
product: MODEL1310110045#

metaM dgmp c
boundary condition: false
is: HMDB01044
is: SBO:0000247
type: Species
notes: FORMULA: C10H12N5O7P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00306 EHMN_ABBREVIATION: C00362
constant: false
initial amount: NaN
has only substance units: false
name: dGMP
is: C00362
initial concentration: 1.0
is: CHEBI:57673

metaR GTHO
product: MODEL1310110045#
notes: GENE_ASSOCIATION: (2936.1) SUBSYSTEM: Glutamate metabolism EC Number: 1.8.1.7 Confidence Level: 2 AUTHORS: PMID:10708558 NOTES:NCD, TV This EC (1.6.4.2) is obsolete. The new EC is 1.8.1.7. http://www.genome.ad.jp/dbget-bin/www_bget?ec:1.6.4.2
reversible: false
type: Reaction
is: SBO:0000176
fast: false
name: glutathione oxidoreductase
modifier: MODEL1310110045#
reactant: MODEL1310110045#
is described by: ECO:0000254
kinetic law: MODEL1310110045#
is version of: http://identifiers.org/ec-code/1.8.1.7

metaR GALASE16ly
is: SBO:0000176
modifier: MODEL1310110045#
kinetic law: MODEL1310110045#
type: Reaction
fast: false
product: MODEL1310110045#
reversible: false
is version of: http://identifiers.org/ec-code/3.1.6.4
is version of: http://identifiers.org/ec-code/3.2.1.23
is described by: ECO:0000000
reactant: MODEL1310110045#
is version of: http://identifiers.org/ec-code/3.2.1.18
is version of: http://identifiers.org/ec-code/3.4.16.5
name: beta-galactosidase, lysosomal
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) or (5476.1) and (2720.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.23 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD

http://identifiers.org/biomodels.db/MODEL1310110045#_6ee5748a_d3c3_446c_92a6_1b7280d23da1
is encoded by: hsa:6535
is: B4DIA3
name: SLC6A8
is: SBO:0000252
constant: false
initial concentration: NaN
has only substance units: false
boundary condition: true
initial amount: NaN
type: Species

metaR SPHK21c
reversible: false
name: sphingosine kinase 2
kinetic law: MODEL1310110045#
type: Reaction
is described by: ECO:0000269
modifier: MODEL1310110045#
is: SBO:0000176
notes: GENE_ASSOCIATION: (56848.1) SUBSYSTEM: Sphingolipid metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:10751414 NOTES:NJ
product: MODEL1310110045#
fast: false
reactant: MODEL1310110045#
is version of: http://identifiers.org/ec-code/2.7.1.91

metaM pd3 c
name: Previtamin D3
initial concentration: 1.0
is: SBO:0000247
is: HMDB06500
boundary condition: false
constant: false
has only substance units: false
initial amount: NaN
type: Species
notes: FORMULA: C27H44O CHARGE: 0 INCHI: InChI=1/C27H44O/c1-19(2)8-6-9-21(4)25-15-16-26-22(10-7-17-27(25,26)5)12-13-23-18-24(28)14-11-20(23)3/h10,12-13,19,21,24-26,28H,6-9,11,14-18H2,1-5H3/b13-12-/t21-,24+,25-,26?,27-/m1/s1

metaR PROt4 2 r
reactant: MODEL1310110045#
type: Reaction
product: MODEL1310110045#
is described by: ECO:0000006
fast: false
reversible: true
kinetic law: MODEL1310110045#
is: SBO:0000185
modifier: MODEL1310110045#
notes: GENE_ASSOCIATION: (6534.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12719981 NOTES:SAB
name: Proline transport (sodium symport) (2:1)

metaR PPNCL3
notes: GENE_ASSOCIATION: (79717.1) SUBSYSTEM: CoA synthesis EC Number: Confidence Level: 4 AUTHORS: NOTES:
fast: false
type: Reaction
is version of: http://identifiers.org/ec-code/6.3.2.5
modifier: MODEL1310110045#
kinetic law: MODEL1310110045#
name: phosphopantothenate-cysteine ligase
reactant: MODEL1310110045#
is described by: ECO:0000269
is: SBO:0000176
reversible: false
product: MODEL1310110045#

metaR COAtp
fast: false
reactant: MODEL1310110045#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD
product: MODEL1310110045#
reversible: true
type: Reaction
kinetic law: MODEL1310110045#
name: coenzyme A transport, peroxisomal
is: SBO:0000185
is described by: ECO:0000000

metaR r0377
name: ATP:deoxycitidine 5-phosphotransferase Pyrimidine metabolism EC:2.7.1.74
fast: false
is described by: ECO:0000000
kinetic law: MODEL1310110045#
notes: GENE_ASSOCIATION: (AI653169.1) or (203.1) or (204.1) or (205.1) or (206.1) or (26289.1) or (122481.1) or (AW277253.1) SUBSYSTEM: Pyrimidine catabolism EC Number: 2.7.1.74 Confidence Level: 0 AUTHORS: PMID:12036920,PMID:1657002,PMID:213049,PMID:8399394,PMID:9342341,PMID:9593124 NOTES:
is: SBO:0000176
reversible: false
is version of: http://identifiers.org/ec-code/2.7.4.3
reactant: MODEL1310110045#
modifier: MODEL1310110045#
type: Reaction
product: MODEL1310110045#

http://identifiers.org/biomodels.db/MODEL1310110045#_18cfd5fc_0504_4f03_9f16_f13553af32d0
has only substance units: false
name: ALDOA
initial concentration: NaN
constant: false
is: SBO:0000252
boundary condition: true
initial amount: NaN
is encoded by: hsa:226
type: Species

metaR NDP7ex
is: SBO:0000176
name: nucleoside-diphosphatase (UDP), extracellular
modifier: MODEL1310110045#
is version of: http://identifiers.org/ec-code/3.6.1.6
reversible: false
kinetic law: MODEL1310110045#
reactant: MODEL1310110045#
product: MODEL1310110045#
notes: GENE_ASSOCIATION: (124583.1) SUBSYSTEM: Nucleotide interconversion EC Number: 3.6.1.6 Confidence Level: 4 AUTHORS: PMID:12600208 NOTES:
type: Reaction
is described by: ECO:0000269
fast: false

metaM oh1 e
has only substance units: false
is: C01328
type: Species
initial concentration: 1.0
is: SBO:0000247
notes: FORMULA: HO CHARGE: -1
is: HMDB01039
constant: false
name: hydroxide ion
initial amount: NaN
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110045#_a81d2299_ee47_49d7_8dfc_f2878a402ccd
is encoded by: hsa:6392
boundary condition: true
has part: Q99643
type: Species
is encoded by: hsa:6390
has only substance units: false
is: SBO:0000297
initial concentration: NaN
initial amount: NaN
constant: false
has part: P21912
has part: O14521
name: SDHA:SDHB:SDHC:SDHD
has part: P31040
is encoded by: hsa:6391
is encoded by: hsa:6389

metaR GTHP
is version of: http://identifiers.org/ec-code/1.11.1.9
name: glutathione peroxidase
is version of: http://identifiers.org/ec-code/1.11.1.12
reactant: MODEL1310110045#
type: Reaction
is: SBO:0000176
kinetic law: MODEL1310110045#
reversible: true
product: MODEL1310110045#
is described by: ECO:0000134
is version of: http://identifiers.org/ec-code/1.11.1.15
modifier: MODEL1310110045#
notes: GENE_ASSOCIATION: (7001.3) or (5052.3) or (2877.1) or (2876.2) or (5052.2) or (2876.1) or (5052.1) or (7001.1) or (2879.1) or (7001.2) SUBSYSTEM: Glutathione metabolism EC Number: 1.11.1.9 Confidence Level: 4 AUTHORS: PMID:15802613,PMID:17015272,PMID:17015273 NOTES:NCD
fast: false

metaM ser L e
initial amount: NaN
initial concentration: 1.0
notes: FORMULA: C3H7NO3 CHARGE: 0 INCHI: InChI=1S/C3H7NO3/c4-2(1-5)3(6)7/h2,5H,1,4H2,(H,6,7)/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00068
type: Species
is: SBO:0000247
has only substance units: false
is: HMDB00187
is: CHEBI:17115
boundary condition: false
constant: false
name: L-serine

metaR BHBtm
reactant: MODEL1310110045#
type: Reaction
product: MODEL1310110045#
is: SBO:0000185
fast: false
reversible: true
name: (R)-3-Hydroxybutanoate mitochondrial transport via H+ symport
kinetic law: MODEL1310110045#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:3427918 NOTES:IT, TDV
is described by: ECO:0000000

metaR LYStm
type: Reaction
name: Lysine mitochondrial transport via ornithine carrier
reactant: MODEL1310110045#
reversible: true
product: MODEL1310110045#
kinetic law: MODEL1310110045#
fast: false
is described by: ECO:0000269
is: SBO:0000185
notes: GENE_ASSOCIATION: (83884.1) or (10166.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172 NOTES:TDV
modifier: MODEL1310110045#

metaM ibcoa m
name: isobutyryl-CoA(4-)
initial amount: NaN
type: Species
has only substance units: false
notes: FORMULA: C25H38N7O17P3S CHARGE: -4 INCHI: InChI=1S/C25H42N7O17P3S/c1-13(2)24(37)53-8-7-27-15(33)5-6-28-22(36)19(35)25(3,4)10-46-52(43,44)49-51(41,42)45-9-14-18(48-50(38,39)40)17(34)23(47-14)32-12-31-16-20(26)29-11-30-21(16)32/h11-14,17-19,23,34-35H,5-10H2,1-4H3,(H,27,33)(H,28,36)(H,41,42)(H,43,44)(H2,26,29,30)(H2,38,39,40)/p-4/t14-,17-,18-,19+,23-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00462 EHMN_ABBREVIATION: C00630
initial concentration: 1.0
constant: false
is: HMDB01243
boundary condition: false
is: SBO:0000247
is: CHEBI:57338

http://identifiers.org/biomodels.db/MODEL1310110045#_c6f7467e_f3db_4864_8a3c_f029d1958d5e
initial concentration: NaN
is: SBO:0000252
constant: false
initial amount: NaN
has only substance units: false
boundary condition: true
type: Species
is encoded by: hsa:6723
is: P19623
name: SRM

metaM HC02217 e
boundary condition: false
initial concentration: 1.0
notes: FORMULA: C20H31O6 CHARGE: -1 INCHI: InChI=1S/C20H32O6/c1-2-3-6-9-15(24-23)12-13-17-16(18-14-19(17)26-25-18)10-7-4-5-8-11-20(21)22/h4,7,12-13,15-19,23H,2-3,5-6,8-11,14H2,1H3,(H,21,22)/b7-4-,13-12+/t15-,16+,17+,18-,19+/m0/s1 EHMN_ABBREVIATION: C05956
is: CHEBI:27647
has only substance units: false
constant: false
name: prostaglandin-g2
initial amount: NaN
is: SBO:0000247
type: Species

metaM duri c
type: Species
boundary condition: false
is: CHEBI:16450
is: HMDB00012
is: C00526
name: Deoxyuridine
is: SBO:0000247
notes: FORMULA: C9H12N2O5 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00410 EHMN_ABBREVIATION: C00526
initial concentration: 1.0
initial amount: NaN
constant: false
has only substance units: false

metaR PUNP6
type: Reaction
reversible: true
is described by: ECO:0000269
modifier: MODEL1310110045#
is version of: http://identifiers.org/ec-code/2.4.2.1
kinetic law: MODEL1310110045#
notes: GENE_ASSOCIATION: (4860.1) SUBSYSTEM: Purine catabolism EC Number: 3.4.2.1 Confidence Level: 4 AUTHORS: PMID:14706628,PMID:6087295,PMID:9305963 NOTES:Specificity not completely determined. Can also catalyse ribosyltransferase reactions of the type catalysed by EC 2.4.2.5, nucleoside ribosyltransferase
name: purine-nucleoside phosphorylase (Deoxyinosine)
reactant: MODEL1310110045#
fast: false
is: SBO:0000176
product: MODEL1310110045#

metaR r1459
kinetic law: MODEL1310110045#
is: SBO:0000185
fast: false
reversible: true
name: Transport reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: 1.3.1.27 Confidence Level: 0 AUTHORS: NOTES:
product: MODEL1310110045#
type: Reaction
is described by: ECO:0000000
reactant: MODEL1310110045#

http://identifiers.org/biomodels.db/MODEL1310110045#_23fd600e_6ac9_4a39_8aca_69e1f21d847c
initial amount: NaN
is encoded by: hsa:1718
has only substance units: false
initial concentration: NaN
constant: false
is: Q15392
name: DHCR24
boundary condition: true
type: Species
is: SBO:0000252

metaM sbt D c
name: D-glucitol
is: HMDB00247
is: CHEBI:17924
is: SBO:0000247
boundary condition: false
has only substance units: false
constant: false
initial concentration: 1.0
initial amount: NaN
type: Species
notes: FORMULA: C6H14O6 CHARGE: 0 INCHI: InChI=1S/C6H14O6/c7-1-3(9)5(11)6(12)4(10)2-8/h3-12H,1-2H2/t3-,4+,5-,6-/m1/s1

metaM g2m8mpdol L r
name: (alpha-D-Glucosyl)2-(alpha-D-mannosyl)8-beta-D-mannosyl-diacetylchitobiosyldiphosphodolichol, human liver homolog
is: SBO:0000247
type: Species
initial amount: NaN
has only substance units: false
is: C05870
initial concentration: 1.0
constant: false
notes: FORMULA: C1900H3128N20O720P20 CHARGE: -20
boundary condition: false

metaR r0941
fast: false
reversible: true
name: Free diffusion
product: MODEL1310110045#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:911815 NOTES:
is: SBO:0000185
type: Reaction
kinetic law: MODEL1310110045#
is described by: ECO:0000000
reactant: MODEL1310110045#

metaR EX malttr LPAREN e RPAREN
kinetic law: MODEL1310110045#
reactant: MODEL1310110045#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Maltotriose exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110045#_03592254_8b47_409d_b350_a58bb7a70e44
initial amount: NaN
is encoded by: hsa:5831
type: Species
name: PYCR1
boundary condition: true
constant: false
initial concentration: NaN
is: A6NFM2
has only substance units: false
is: SBO:0000252

metaR r1548
is: SBO:0000185
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is described by: ECO:0000000
reactant: MODEL1310110045#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
kinetic law: MODEL1310110045#
type: Reaction
product: MODEL1310110045#
reversible: true

metaR FAOXC14DCC12DCx
kinetic law: MODEL1310110045#
product: MODEL1310110045#
reactant: MODEL1310110045#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C14DC-->C12DC)x
type: Reaction

metaM ksii core4 pre4 g
is: SBO:0000247
type: Species
initial concentration: 1.0
is: CHEBI:58053
name: keratan sulfate II biosynthesis, precursor 4
notes: FORMULA: C61H99N5O43X CHARGE: -1
boundary condition: false
is: HMDB00175
initial amount: NaN
is: C00130
has only substance units: false
constant: false

metaR PUNP5
is described by: ECO:0000269
is: SBO:0000176
kinetic law: MODEL1310110045#
reactant: MODEL1310110045#
type: Reaction
reversible: true
fast: false
name: purine-nucleoside phosphorylase (Inosine)
modifier: MODEL1310110045#
product: MODEL1310110045#
is version of: http://identifiers.org/ec-code/2.4.2.1
notes: GENE_ASSOCIATION: (4860.1) SUBSYSTEM: Purine catabolism EC Number: 3.4.2.1 Confidence Level: 4 AUTHORS: PMID:14706628,PMID:6087295,PMID:9305963 NOTES:Specificity not completely determined. Can also catalyse ribosyltransferase reactions of the type catalysed by EC 2.4.2.5, nucleoside ribosyltransferase

http://identifiers.org/biomodels.db/MODEL1310110045#_68766a81_4e49_4277_8e8c_38c7d86d783e
constant: false
is: SBO:0000252
type: Species
initial amount: NaN
is: P49448
name: GLUD2
has only substance units: false
initial concentration: NaN
boundary condition: true
is encoded by: hsa:2747

metaM CE5854 e
type: Species
notes: FORMULA: C21H27O10 CHARGE: -1 INCHI: InChI=1/C21H28O10/c1-9-10(2)17-11(8-12(9)22)4-6-21(3,31-17)7-5-13(23)29-20-16(26)14(24)15(25)18(30-20)19(27)28/h8,14-16,18,20,22,24-26H,4-7H2,1-3H3,(H,27,28)/p-1/t14-,15+,16-,18-,20+,21?/m1/s1 EHMN_ABBREVIATION: CE5854
is: HMDB02710
is: CHEBI:27485
has only substance units: false
initial concentration: 1.0
initial amount: NaN
constant: false
name: gama-CEHC-glucuronide
boundary condition: false
is: SBO:0000247

metaR r0594
kinetic law: MODEL1310110045#
is described by: ECO:0000000
product: MODEL1310110045#
is version of: http://identifiers.org/ec-code/1.2.1.3
name: L-2-Aminoadipate-6-semialdehyde:NAD+ 6-oxidoreductase Lysine degradation EC:1.2.1.31
reversible: true
modifier: MODEL1310110045#
notes: GENE_ASSOCIATION: (AA081045.1) or (AI620219.1) or (219.1) or (217.1) or (224.1) or (501.1) or (223.1) or (AU149534.1) or (T83654.1) SUBSYSTEM: Lysine metabolism EC Number: 1.2.1.31 Confidence Level: 0 AUTHORS: PMID:2160277 NOTES:
is: SBO:0000176
type: Reaction
reactant: MODEL1310110045#
fast: false

metaM CE0233 c
notes: FORMULA: C27H48O3 CHARGE: 0 INCHI: InChI=1/C27H48O3/c1-17(7-6-12-25(2,3)30)20-8-9-21-24-22(11-14-27(20,21)5)26(4)13-10-19(28)15-18(26)16-23(24)29/h17-24,28-30H,6-16H2,1-5H3/t17-,18-,19+,20-,21-,22-,23+,24-,26?,27-/m1/s1 EHMN_ABBREVIATION: CE0233
is: SBO:0000247
has only substance units: false
is: HMDB01993
boundary condition: false
type: Species
initial amount: NaN
initial concentration: 1.0
constant: false
name: 5beta-cholestane-3alpha,7alpha,27-triol
is: CHEBI:17899

metaR r0940
reactant: MODEL1310110045#
fast: false
product: MODEL1310110045#
type: Reaction
is described by: ECO:0000000
is: SBO:0000185
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
name: Free diffusion
kinetic law: MODEL1310110045#

metaR r1549
fast: false
kinetic law: MODEL1310110045#
product: MODEL1310110045#
is described by: ECO:0000000
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
type: Reaction
reversible: true
reactant: MODEL1310110045#

metaR r0718
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (80270.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.1.1.35 Confidence Level: 0 AUTHORS: PMID:10231530,PMID:10329704,PMID:1550553,PMID:1651711,PMID:7150615,PMID:8188243,PMID:8687463,PMID:9553139 NOTES:
reversible: false
type: Reaction
name: (S)-3-Hydroxytetradecanoyl-CoA:NAD+ oxidoreductase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:1.1.1.35 EC:1.1.1.211
is version of: http://identifiers.org/ec-code/1.1.1.181
kinetic law: MODEL1310110045#
modifier: MODEL1310110045#
reactant: MODEL1310110045#
fast: false
is: SBO:0000176
product: MODEL1310110045#

metaR EX hco3 LPAREN e RPAREN
kinetic law: MODEL1310110045#
reactant: MODEL1310110045#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Bicarbonate exchange
type: Reaction

metaR S6T17g
notes: GENE_ASSOCIATION: (23563.2) or (9435.1) or (23563.1) or (10164.1) or (4166.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: Confidence Level: 4 AUTHORS: PMID:10330415,PMID:10491328,PMID:10913333,PMID:11278593,PMID:12403612,PMID:12855678,PMID:9722682 NOTES:NCD
fast: false
name: galactose/N-acetylglucosamine 6-O-sulfotransferase, Golgi apparatus
is described by: ECO:0000000
kinetic law: MODEL1310110045#
modifier: MODEL1310110045#
type: Reaction
product: MODEL1310110045#
reversible: false
is: SBO:0000176
reactant: MODEL1310110045#

metaM asp L c
boundary condition: false
initial amount: NaN
is: SBO:0000247
notes: FORMULA: C4H6NO4 CHARGE: -1 INCHI: InChI=1S/C4H7NO4/c5-2(4(8)9)1-3(6)7/h2H,1,5H2,(H,6,7)(H,8,9)/p-1/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00055
constant: false
is: HMDB00191
is: CHEBI:29991
name: L-aspartate(1-)
has only substance units: false
initial concentration: 1.0
type: Species

http://identifiers.org/biomodels.db/MODEL1310110045#_d2a0f238_57f6_4d7b_aaf7_a9d257015025
type: Species
has only substance units: false
name: PAPSS2
initial amount: NaN
is encoded by: hsa:9060
initial concentration: NaN
is: SBO:0000252
is: O95340
constant: false
boundary condition: true

metaR PUNP4
is: SBO:0000176
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/2.4.2.1
fast: false
product: MODEL1310110045#
type: Reaction
kinetic law: MODEL1310110045#
notes: GENE_ASSOCIATION: (4860.1) SUBSYSTEM: Purine catabolism EC Number: 3.4.2.1 Confidence Level: 4 AUTHORS: PMID:6087295,PMID:9305963 NOTES:Specificity not completely determined. Can also catalyse ribosyltransferase reactions of the type catalysed by EC 2.4.2.5, nucleoside ribosyltransferase
modifier: MODEL1310110045#
reversible: true
reactant: MODEL1310110045#
name: purine-nucleoside phosphorylase (Deoxyguanosine)

metaM duri e
is: CHEBI:16450
is: C00526
is: HMDB00012
has only substance units: false
boundary condition: false
is: SBO:0000247
name: Deoxyuridine
notes: FORMULA: C9H12N2O5 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00410 EHMN_ABBREVIATION: C00526
initial amount: NaN
constant: false
initial concentration: 1.0
type: Species

metaM ficytC m
notes: FORMULA: C42H54FeN8O6S2 CHARGE: 3 HEPATONET_1.0_ABBREVIATION: HC00123
boundary condition: false
is: CHEBI:15991
constant: false
has only substance units: false
initial concentration: 1.0
initial amount: NaN
name: Ferricytochrome c
is: SBO:0000247
type: Species

metaM HC02217 c
initial concentration: 1.0
notes: FORMULA: C20H31O6 CHARGE: -1 INCHI: InChI=1S/C20H32O6/c1-2-3-6-9-15(24-23)12-13-17-16(18-14-19(17)26-25-18)10-7-4-5-8-11-20(21)22/h4,7,12-13,15-19,23H,2-3,5-6,8-11,14H2,1H3,(H,21,22)/b7-4-,13-12+/t15-,16+,17+,18-,19+/m0/s1 EHMN_ABBREVIATION: C05956
has only substance units: false
is: CHEBI:27647
name: prostaglandin-g2
constant: false
initial amount: NaN
is: SBO:0000247
type: Species
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110045#_2e476ce2_9e29_434e_810a_4588d023873d
initial concentration: NaN
constant: false
is encoded by: hsa:8867
is: SBO:0000252
has only substance units: false
name: SYNJ1
is: C9JFZ1
boundary condition: true
initial amount: NaN
type: Species

http://identifiers.org/biomodels.db/MODEL1310110045#_e1bb3624_e915_47f0_be7b_c5683ba241dc
initial concentration: NaN
initial amount: NaN
has only substance units: false
is: E9PB82
type: Species
boundary condition: true
is: SBO:0000252
is encoded by: hsa:3295
constant: false
name: HSD17B4

metaM 3octpencoa m
constant: false
initial concentration: 1.0
boundary condition: false
is: SBO:0000247
notes: FORMULA: C39H56N7O17P3S CHARGE: -4
type: Species
is: HMDB06294
name: 3,6,9,12,15-octadecapentenoylcoa
has only substance units: false
initial amount: NaN

metaM kynate c
name: kynurenate
constant: false
is: SBO:0000247
is: HMDB00715
type: Species
is: CHEBI:58454
has only substance units: false
initial amount: NaN
notes: FORMULA: C10H6NO3 CHARGE: -1 INCHI: InChI=1S/C10H7NO3/c12-9-5-8(10(13)14)11-7-4-2-1-3-6(7)9/h1-5H,(H,11,12)(H,13,14)/p-1 EHMN_ABBREVIATION: C01717
boundary condition: false
initial concentration: 1.0

metaR NADtx
type: Reaction
reversible: true
reactant: MODEL1310110045#
is described by: ECO:0000134
name: transport of NAD into peroxisome
product: MODEL1310110045#
kinetic law: MODEL1310110045#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: NOTES:
is: SBO:0000185

metaR CYTK11n
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
is version of: http://identifiers.org/ec-code/2.7.4.14
name: cytidylate kinase (dCMP,dGTP),nuclear
is: SBO:0000176
kinetic law: MODEL1310110045#
product: MODEL1310110045#
fast: false
reversible: true
type: Reaction
reactant: MODEL1310110045#
modifier: MODEL1310110045#
is described by: ECO:0000269

metaM CE0849 m
name: cis,cis-palmito-7,10-dienoyl-CoA
is: CHEBI:57795
is: SBO:0000247
notes: FORMULA: C37H58N7O17P3S CHARGE: -4 INCHI: InChI=1/C37H62N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-28(46)65-21-20-39-27(45)18-19-40-35(49)32(48)37(2,3)23-58-64(55,56)61-63(53,54)57-22-26-31(60-62(50,51)52)30(47)36(59-26)44-25-43-29-33(38)41-24-42-34(29)44/h8-9,11-12,24-26,30-32,36,47-48H,4-7,10,13-23H2,1-3H3,(H,39,45)(H,40,49)(H,53,54)(H,55,56)(H2,38,41,42)(H2,50,51,52)/p-4/b9-8-,12-11-/t26-,30+,31+,32u,36-/m0/s1 EHMN_ABBREVIATION: CE0849
constant: false
type: Species
has only substance units: false
initial amount: NaN
initial concentration: 1.0
boundary condition: false

metaR r1546
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
product: MODEL1310110045#
is: SBO:0000185
fast: false
reversible: true
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
kinetic law: MODEL1310110045#
is described by: ECO:0000000
reactant: MODEL1310110045#

metaR 2AMACHYD
reversible: false
reactant: MODEL1310110045#
product: MODEL1310110045#
is: SBO:0000176
is described by: ECO:0000000
fast: false
type: Reaction
name: 2-Aminoacrylate hydrolysis
kinetic law: MODEL1310110045#
notes: GENE_ASSOCIATION: SUBSYSTEM: Glycine, serine, alanine and threonine metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:500639 NOTES:SAB see PMID 500639: this reaction is spontaneous

http://identifiers.org/biomodels.db/MODEL1310110045#_619025ed_e164_449c_918e_e6d577ab0ed5
boundary condition: true
is: SBO:0000252
initial amount: NaN
type: Species
is encoded by: hsa:767
has only substance units: false
initial concentration: NaN
constant: false
name: CA8
is: P35219

metaR r0717
product: MODEL1310110045#
is described by: ECO:0000000
fast: false
reactant: MODEL1310110045#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.17 Confidence Level: 0 AUTHORS: PMID:8012501,PMID:8188243 NOTES:
reversible: false
is: SBO:0000176
kinetic law: MODEL1310110045#
name: (S)-3-Hydroxyhexadecanoyl-CoA hydro-lyase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:4.2.1.17

metaR GAL3ST11
fast: false
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.8.2.11
name: Galactosylceramide sulfotransferase
type: Reaction
product: MODEL1310110045#
reactant: MODEL1310110045#
kinetic law: MODEL1310110045#
notes: GENE_ASSOCIATION: (9514.1) SUBSYSTEM: Sphingolipid metabolism EC Number: 2.8.2.11 Confidence Level: 4 AUTHORS: PMID:9030544 NOTES:NJ
reversible: false
is described by: ECO:0000000
modifier: MODEL1310110045#

http://identifiers.org/biomodels.db/MODEL1310110045#_062663e3_89c9_49a5_9c61_44c5e6752d00
constant: false
boundary condition: true
initial amount: NaN
is: P41247
initial concentration: NaN
is encoded by: hsa:8228
type: Species
name: PNPLA4
has only substance units: false
is: SBO:0000252

metaR PUNP3
product: MODEL1310110045#
fast: false
name: purine-nucleoside phosphorylase (Guanosine)
kinetic law: MODEL1310110045#
notes: GENE_ASSOCIATION: (4860.1) SUBSYSTEM: Purine catabolism EC Number: 3.4.2.1 Confidence Level: 4 AUTHORS: PMID:6087295,PMID:9305963 NOTES:Specificity not completely determined. Can also catalyse ribosyltransferase reactions of the type catalysed by EC 2.4.2.5, nucleoside ribosyltransferase
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.4.2.1
reactant: MODEL1310110045#
type: Reaction
is described by: ECO:0000269
modifier: MODEL1310110045#
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110045#_f1bbb239_dc02_4840_ba39_a4cf16aab073
name: SLC25A5
constant: false
is: SBO:0000252
has only substance units: false
type: Species
is: Q6NVC0
is encoded by: hsa:292
boundary condition: true
initial concentration: NaN
initial amount: NaN

metaM maltpt e
is: http://identifiers.org/pubchem.compound/5141
is: HMDB01296
type: Species
initial amount: NaN
boundary condition: false
has only substance units: false
is: SBO:0000247
notes: FORMULA: C30H52O26 CHARGE: 0 EHMN_ABBREVIATION: CE2835
constant: false
initial concentration: 1.0
is: C02052
name: maltopentaose

metaR r0596
is described by: ECO:0000000
reversible: false
kinetic law: MODEL1310110045#
product: MODEL1310110045#
name: 3-hydroxyisobutyryl-CoA hydrolase beta-Alanine metabolism / Propanoate metabolism EC:3.1.2.4
type: Reaction
reactant: MODEL1310110045#
is: SBO:0000176
notes: GENE_ASSOCIATION: (6576.1) SUBSYSTEM: CoA synthesis EC Number: 3.1.2.4 Confidence Level: 0 AUTHORS: PMID:10989434,PMID:8188708,PMID:8824301 NOTES:
fast: false
modifier: MODEL1310110045#

metaM dgmp m
type: Species
notes: FORMULA: C10H12N5O7P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00306 EHMN_ABBREVIATION: C00362
name: dGMP
boundary condition: false
constant: false
initial concentration: 1.0
is: CHEBI:57673
is: SBO:0000247
is: C00362
initial amount: NaN
is: HMDB01044
has only substance units: false

metaM lys L n
has only substance units: false
is: SBO:0000247
constant: false
initial amount: NaN
is: CHEBI:32551
type: Species
initial concentration: 1.0
is: HMDB00182
notes: FORMULA: C6H15N2O2 CHARGE: 1 INCHI: InChI=1S/C6H14N2O2/c7-4-2-1-3-5(8)6(9)10/h5H,1-4,7-8H2,(H,9,10)/p+1/t5-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00053 EHMN_ABBREVIATION: C00047
boundary condition: false
name: L-lysinium(1+)

metaR DADAe
is: SBO:0000176
fast: false
type: Reaction
is described by: ECO:0000269
kinetic law: MODEL1310110045#
modifier: MODEL1310110045#
reactant: MODEL1310110045#
product: MODEL1310110045#
name: Deoxyadenosine deaminase, extracellular
is version of: http://identifiers.org/ec-code/3.5.4.4
reversible: false
notes: GENE_ASSOCIATION: (100.1) SUBSYSTEM: Nucleotide interconversion EC Number: 3.5.4.4 Confidence Level: 4 AUTHORS: PMID:12381379,PMID:15016824 NOTES:adenosine deaminase has been found on cell surface in human (Gonzales-Gronow et al, JBC, 2004,279,20993-20998). IT

http://identifiers.org/biomodels.db/MODEL1310110045#_bcea4d9f_58d3_45b4_8c34_efe55275eed3
initial amount: NaN
type: Species
initial concentration: NaN
is: P51828
constant: false
is encoded by: hsa:113
boundary condition: true
is: SBO:0000252
has only substance units: false
name: ADCY7

metaR r1547
reversible: true
reactant: MODEL1310110045#
is described by: ECO:0000000
product: MODEL1310110045#
is: SBO:0000185
fast: false
type: Reaction
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
kinetic law: MODEL1310110045#

metaR r0716
reactant: MODEL1310110045#
is: SBO:0000176
name: (S)-3-Hydroxyhexadecanoyl-CoA hydro-lyase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:4.2.1.17
reversible: false
is described by: ECO:0000000
kinetic law: MODEL1310110045#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 4.2.1.17 Confidence Level: 0 AUTHORS: PMID:8012501,PMID:8188243 NOTES:
product: MODEL1310110045#
fast: false

metaR r0591
is described by: ECO:0000000
reactant: MODEL1310110045#
notes: GENE_ASSOCIATION: (220.1) or (218.1) or (221.1) or (222.1) or (U37519.1) SUBSYSTEM: CoA synthesis EC Number: 3.6.1.9 Confidence Level: 0 AUTHORS: PMID:11579996,PMID:11946484 NOTES:
kinetic law: MODEL1310110045#
name: Dephospho-CoA nucleotidohydrolase Pantothenate and CoA biosynthesis EC:3.6.1.9
type: Reaction
is: SBO:0000176
reversible: true
product: MODEL1310110045#
is version of: http://identifiers.org/ec-code/1.2.1.5
modifier: MODEL1310110045#
fast: false

metaM ksi pre32 g
is: CHEBI:28067
initial amount: NaN
boundary condition: false
type: Species
notes: FORMULA: C227H362N16O192S10X CHARGE: -11
constant: false
is: SBO:0000247
name: keratan sulfate I biosynthesis, precursor 32
has only substance units: false
initial concentration: 1.0

metaR RE3628M
fast: false
is version of: http://identifiers.org/ec-code/1.1.1.35
product: MODEL1310110045#
reversible: true
notes: GENE_ASSOCIATION: (1632.1) or (10455.1) or (1962.1) SUBSYSTEM: Fatty acid oxidation EC Number: 5.3.3.8 Confidence Level: 0 AUTHORS: PMID:11356164,PMID:7775433 NOTES:
is version of: http://identifiers.org/ec-code/5.3.3.8
type: Reaction
modifier: MODEL1310110045#
name: RE3628
is described by: ECO:0000000
is: SBO:0000176
kinetic law: MODEL1310110045#
reactant: MODEL1310110045#

metaR FAOXC140
is version of: http://identifiers.org/ec-code/1.3.99.3
notes: GENE_ASSOCIATION: (35.1) or (34.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.99.3 Confidence Level: 4 AUTHORS: PMID:2565344 NOTES:TV Other enzymes: 1.3.3.6, 4.2.1.74, 4.2.1.17, 1.1.1.35, 1.1.1.211
is version of: http://identifiers.org/ec-code/1.3.8.1
type: Reaction
is: SBO:0000176
name: Beta oxidation of long chain fatty acid
reactant: MODEL1310110045#
is described by: ECO:0000269
reversible: false
modifier: MODEL1310110045#
fast: false
kinetic law: MODEL1310110045#
product: MODEL1310110045#

metaR EX cmp LPAREN e RPAREN
kinetic law: MODEL1310110045#
reactant: MODEL1310110045#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: CMP exchange
type: Reaction

metaR EX co2 LPAREN e RPAREN
kinetic law: MODEL1310110045#
reactant: MODEL1310110045#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: CO2 exchange
type: Reaction

metaR PUNP2
name: purine-nucleoside phosphorylase (Deoxyadenosine)
product: MODEL1310110045#
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (4860.1) SUBSYSTEM: Purine catabolism EC Number: 3.4.2.1 Confidence Level: 4 AUTHORS: PMID:6087295,PMID:9305963 NOTES:Specificity not completely determined. Can also catalyse ribosyltransferase reactions of the type catalysed by EC 2.4.2.5, nucleoside ribosyltransferase
type: Reaction
is version of: http://identifiers.org/ec-code/2.4.2.1
fast: false
kinetic law: MODEL1310110045#
reversible: true
modifier: MODEL1310110045#
reactant: MODEL1310110045#
is: SBO:0000176

metaR r2015
reactant: MODEL1310110045#
product: MODEL1310110045#
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reversible: false
type: Reaction
is: SBO:0000185
fast: false
is described by: ECO:0000000
kinetic law: MODEL1310110045#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.15
modifier: MODEL1310110045#

http://identifiers.org/biomodels.db/MODEL1310110045#_03af0f3b_5ac8_4572_984a_97b7e9c57f4d
type: Species
constant: false
initial amount: NaN
has only substance units: false
name: _AI091231_1_c
initial concentration: NaN
is encoded by: hsa:AI091231
boundary condition: true
is: SBO:0000252

metaR r1544
product: MODEL1310110045#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reversible: true
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
fast: false
is: SBO:0000185
is described by: ECO:0000000
kinetic law: MODEL1310110045#
reactant: MODEL1310110045#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110045#_ea3631c7_65bf_4812_bb42_cb747b0a8239
is: SBO:0000252
is encoded by: hsa:788
name: SLC25A20
boundary condition: true
has only substance units: false
constant: false
is: O43772
initial concentration: NaN
type: Species
initial amount: NaN

metaR r0715
reversible: false
notes: GENE_ASSOCIATION: (AI435857.1) or (79717.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.1.1.35 Confidence Level: 0 AUTHORS: PMID:10231530,PMID:10329704,PMID:1550553,PMID:1651711,PMID:7150615,PMID:8188243,PMID:8687463,PMID:9553139 NOTES:
is described by: ECO:0000000
reactant: MODEL1310110045#
type: Reaction
product: MODEL1310110045#
name: (S)-3-Hydroxyhexadecanoyl-CoA:NAD+ oxidoreductase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:1.1.1.35 EC:1.1.1.211
fast: false
is: SBO:0000176
is version of: http://identifiers.org/ec-code/6.3.2.5
kinetic law: MODEL1310110045#
modifier: MODEL1310110045#

metaM ppa e
has only substance units: false
initial amount: NaN
notes: FORMULA: C3H5O2 CHARGE: -1 INCHI: InChI=1S/C3H6O2/c1-2-3(4)5/h2H2,1H3,(H,4,5)/p-1 HEPATONET_1.0_ABBREVIATION: HC00158 EHMN_ABBREVIATION: C00163
boundary condition: false
is: SBO:0000247
is: HMDB00237
constant: false
is: CHEBI:17272
type: Species
name: propionate
initial concentration: 1.0

metaR r0590
is version of: http://identifiers.org/ec-code/1.2.1.5
kinetic law: MODEL1310110045#
modifier: MODEL1310110045#
is described by: ECO:0000000
reversible: false
product: MODEL1310110045#
fast: false
name: ATP:pantetheine-4-phosphate adenylyltransferase Pantothenate and CoA biosynthesis EC:2.7.7.3
notes: GENE_ASSOCIATION: (220.1) or (218.1) or (221.1) or (222.1) or (U37519.1) SUBSYSTEM: CoA synthesis EC Number: 2.7.7.3 Confidence Level: 0 AUTHORS: PMID:11923312,PMID:11994049,PMID:13163064,PMID:15893380 NOTES:
type: Reaction
reactant: MODEL1310110045#
is: SBO:0000176

metaM udpg c
constant: false
initial concentration: 1.0
is: SBO:0000247
is: HMDB00286
is: C00029
name: UDPglucose
initial amount: NaN
notes: FORMULA: C15H22N2O17P2 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00038 EHMN_ABBREVIATION: C00029
boundary condition: false
type: Species
is: CHEBI:58367
has only substance units: false

metaR PUNP1
fast: false
kinetic law: MODEL1310110045#
is: SBO:0000176
reactant: MODEL1310110045#
notes: GENE_ASSOCIATION: (4860.1) SUBSYSTEM: Nucleotide interconversion EC Number: 3.4.2.1 Confidence Level: 4 AUTHORS: PMID:6087295,PMID:9305963 NOTES:Specificity not completely determined. Can also catalyse ribosyltransferase reactions of the type catalysed by EC 2.4.2.5, nucleoside ribosyltransferase
type: Reaction
is version of: http://identifiers.org/ec-code/2.4.2.1
name: purine-nucleoside phosphorylase (Adenosine)
product: MODEL1310110045#
reversible: true
is described by: ECO:0000269
modifier: MODEL1310110045#

metaM 4nphsf e
initial amount: NaN
type: Species
has only substance units: false
is: HMDB06492
boundary condition: false
initial concentration: 1.0
name: 4-Nitrophenyl sulfate
constant: false
notes: FORMULA: C6H4NO6S CHARGE: -1 INCHI: InChI=1S/C6H5NO6S/c8-7(9)5-1-3-6(4-2-5)13-14(10,11)12/h1-4H,(H,10,11,12)
is: SBO:0000247
is: CHEBI:35422

http://identifiers.org/biomodels.db/MODEL1310110045#_262a64b5_e14d_498b_8d52_a1e48a6dbf24
constant: false
name: DGUOK
is encoded by: hsa:1716
has only substance units: false
is: SBO:0000252
boundary condition: true
is: Q16854
initial amount: NaN
type: Species
initial concentration: NaN

metaR RE3301C
kinetic law: MODEL1310110045#
is described by: ECO:0000000
fast: false
modifier: MODEL1310110045#
notes: GENE_ASSOCIATION: (5338.1) SUBSYSTEM: Glycerophospholipid metabolism EC Number: 3.1.4.4 Confidence Level: 0 AUTHORS: PMID:11182251 NOTES:
type: Reaction
name: RE3301
is version of: http://identifiers.org/ec-code/3.1.4.4
is: SBO:0000176
product: MODEL1310110045#
reactant: MODEL1310110045#
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110045#_65f8fdfe_24e7_4567_a36f_f0582afd10c1
boundary condition: true
has only substance units: false
type: Species
initial concentration: NaN
is encoded by: hsa:51022
name: GLRX2
is: SBO:0000252
constant: false
initial amount: NaN

metaR r2016
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.15
is described by: ECO:0000000
reactant: MODEL1310110045#
product: MODEL1310110045#
reversible: false
is: SBO:0000185
modifier: MODEL1310110045#
fast: false
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
kinetic law: MODEL1310110045#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110045#_976dc8fd_19db_41f1_bd15_7eb3f051bf28
initial concentration: NaN
name: GCNT4
initial amount: NaN
is encoded by: hsa:51301
is: SBO:0000252
type: Species
constant: false
has only substance units: false
is: Q9P109
boundary condition: true

metaR ASNNm
is version of: http://identifiers.org/ec-code/3.5.1.1
is described by: ECO:0000254
product: MODEL1310110045#
name: L-asparaginase (mitochondrial)
is: SBO:0000176
reactant: MODEL1310110045#
type: Reaction
modifier: MODEL1310110045#
reversible: false
notes: GENE_ASSOCIATION: (80150.1) SUBSYSTEM: Alanine and aspartate metabolism EC Number: 3.5.1.1 Confidence Level: 2 AUTHORS: PMID:11984834 NOTES:PMID: 11984834 (denotes it as potentially mitochondrial) mm
kinetic law: MODEL1310110045#
fast: false

metaM nmn c
is: SBO:0000247
is: CHEBI:14649
initial amount: NaN
constant: false
name: NMN
is: HMDB00229
has only substance units: false
is: C00455
type: Species
notes: FORMULA: C11H14N2O8P CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00366 EHMN_ABBREVIATION: C00455
initial concentration: 1.0
boundary condition: false

metaM oxa m
boundary condition: false
has only substance units: false
initial concentration: 1.0
is: HMDB02329
name: oxalate(2-)
is: CHEBI:30623
constant: false
initial amount: NaN
type: Species
is: SBO:0000247
notes: FORMULA: C2O4 CHARGE: -2 INCHI: InChI=1S/C2H2O4/c3-1(4)2(5)6/h(H,3,4)(H,5,6)/p-2 HEPATONET_1.0_ABBREVIATION: HC00195 EHMN_ABBREVIATION: C00209

http://identifiers.org/biomodels.db/MODEL1310110045#_1cec8705_854c_4146_9c2e_ba76e9aa9615
is: SBO:0000252
initial amount: NaN
is: P49247
type: Species
initial concentration: NaN
has only substance units: false
name: RPIA
constant: false
boundary condition: true
is encoded by: hsa:22934

http://identifiers.org/biomodels.db/MODEL1310110045#_7526be58_2c3a_4144_bf83_be93f1ef4905
has only substance units: false
is: P48735
type: Species
is: SBO:0000252
initial concentration: NaN
boundary condition: true
name: IDH2
initial amount: NaN
constant: false
is encoded by: hsa:3418

metaR r0714
reactant: MODEL1310110045#
is: SBO:0000176
product: MODEL1310110045#
name: (S)-3-Hydroxyhexadecanoyl-CoA:NAD+ oxidoreductase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:1.1.1.211 EC:1.1.1.35
fast: false
is described by: ECO:0000000
type: Reaction
kinetic law: MODEL1310110045#
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: 1.1.1.35 Confidence Level: 0 AUTHORS: PMID:10231530,PMID:10329704,PMID:1550553,PMID:1651711,PMID:7150615,PMID:8188243,PMID:8687463,PMID:9553139 NOTES:
reversible: false

metaR ADK3m
is described by: ECO:0000269
kinetic law: MODEL1310110045#
is version of: http://identifiers.org/ec-code/2.7.4.10
is: SBO:0000176
type: Reaction
modifier: MODEL1310110045#
reactant: MODEL1310110045#
reversible: true
notes: GENE_ASSOCIATION: (50808.1) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: PMID:11485571 NOTES:NCD
name: adentylate kinase (GTP)
product: MODEL1310110045#
fast: false

http://identifiers.org/biomodels.db/MODEL1310110045#_004990d8_b647_4d34_a6ff_13e582abda06
type: Species
is: F6SH78
name: ELOVL5
initial concentration: NaN
has only substance units: false
constant: false
boundary condition: true
initial amount: NaN
is: SBO:0000252
is encoded by: hsa:60481

metaM pap c
type: Species
is: SBO:0000247
initial concentration: 1.0
initial amount: NaN
name: adenosine 3',5'-bismonophosphate(4-)
constant: false
is: HMDB00061
boundary condition: false
is: CHEBI:58343
notes: FORMULA: C10H11N5O10P2 CHARGE: -4 INCHI: InChI=1S/C10H15N5O10P2/c11-8-5-9(13-2-12-8)15(3-14-5)10-6(16)7(25-27(20,21)22)4(24-10)1-23-26(17,18)19/h2-4,6-7,10,16H,1H2,(H2,11,12,13)(H2,17,18,19)(H2,20,21,22)/p-4/t4-,6-,7-,10-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00059 EHMN_ABBREVIATION: C00054
has only substance units: false

metaM bilglcur r
has only substance units: false
is: SBO:0000247
type: Species
is: CHEBI:57767
initial concentration: 1.0
notes: FORMULA: C39H44N4O12 CHARGE: 0 INCHI: InChI=1S/C39H44N4O12/c1-7-20-19(6)36(50)43-27(20)14-25-18(5)23(10-12-31(46)54-39-34(49)32(47)33(48)35(55-39)38(52)53)29(41-25)15-28-22(9-11-30(44)45)17(4)24(40-28)13-26-16(3)21(8-2)37(51)42-26/h7-8,13-14,32-35,39-41,47-49H,1-2,9-12,15H2,3-6H3,(H,42,51)(H,43,50)(H,44,45)(H,52,53)/p-2/b26-13+,27-14+/t32-,33-,34+,35-,39+/m0/s1 EHMN_ABBREVIATION: C03374
constant: false
name: mono(glucosyluronic acid)bilirubin(2-)
initial amount: NaN
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110045#_4e1ffc29_29a1_40a2_a474_cb4d5ac65556
is encoded by: hsa:7166
is: SBO:0000252
name: TPH1
constant: false
initial amount: NaN
is: P17752
boundary condition: true
initial concentration: NaN
type: Species
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110045#_2e81d175_99e9_41dc_a751_edc5b2fa1d0e
type: Species
boundary condition: true
is encoded by: hsa:53919
has only substance units: false
is: SBO:0000252
initial amount: NaN
is: Q5JPA4
name: SLCO1C1
initial concentration: NaN
constant: false

http://identifiers.org/biomodels.db/MODEL1310110045#_e6e455fb_8b5c_42c8_aff0_8d3286c037d1
initial amount: NaN
is encoded by: hsa:4719
boundary condition: true
constant: false
initial concentration: NaN
is: SBO:0000252
type: Species
is: P28331
has only substance units: false
name: NDUFS1

metaM acgam l
is: CHEBI:17411
boundary condition: false
initial concentration: 1.0
type: Species
has only substance units: false
name: N-acetyl-D-glucosamine
is: HMDB00215
notes: FORMULA: C8H15NO6 CHARGE: 0 INCHI: InChI=1S/C8H15NO6/c1-4(12)9-5(2-10)7(14)8(15)6(13)3-11/h2,5-8,11,13-15H,3H2,1H3,(H,9,12)/t5-,6+,7+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00138 EHMN_ABBREVIATION: C00140
is: SBO:0000247
initial amount: NaN
constant: false

http://identifiers.org/biomodels.db/MODEL1310110045#_43a7cd30_8a97_4340_940d_730a083355d9
type: Species
is: SBO:0000252
constant: false
is: P54819
name: AK2
is encoded by: hsa:204
has only substance units: false
initial concentration: NaN
initial amount: NaN
boundary condition: true

metaR r0084
is version of: http://identifiers.org/ec-code/1.1.1.42
product: MODEL1310110045#
reactant: MODEL1310110045#
reversible: true
notes: GENE_ASSOCIATION: (AI971036.1) or (3417.1) or (3418.1) SUBSYSTEM: Unassigned EC Number: 1.1.1.42 Confidence Level: 0 AUTHORS: PMID:16489927,PMID:9866202 NOTES:
fast: false
type: Reaction
modifier: MODEL1310110045#
is: SBO:0000176
is described by: ECO:0000000
name: Oxalosuccinate:NADP+ oxidoreductase (decarboxylating) Citrate cycle (TCA cycle) EC:1.1.1.42
kinetic law: MODEL1310110045#

metaR TALA
reactant: MODEL1310110045#
kinetic law: MODEL1310110045#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.2.1.2
type: Reaction
modifier: MODEL1310110045#
name: transaldolase
fast: false
is described by: ECO:0000000
reversible: true
product: MODEL1310110045#
notes: GENE_ASSOCIATION: (6888.1) SUBSYSTEM: Pentose phosphate pathway EC Number: 2.2.1.2 Confidence Level: 0 AUTHORS: NOTES:SMP

metaR S6T3g
product: MODEL1310110045#
is: SBO:0000176
fast: false
is described by: ECO:0000000
type: Reaction
notes: GENE_ASSOCIATION: (8534.1) or (9469.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: Confidence Level: 4 AUTHORS: PMID:12403612,PMID:8991509,PMID:9405439,PMID:9714738 NOTES:NCD
reversible: false
is version of: http://identifiers.org/ec-code/2.8.2.17
name: galactose/N-acetylglucosamine 6-O-sulfotransferase, Golgi apparatus
reactant: MODEL1310110045#
is version of: http://identifiers.org/ec-code/2.8.2.21
kinetic law: MODEL1310110045#
modifier: MODEL1310110045#

metaR ACGAMPM
reactant: MODEL1310110045#
notes: GENE_ASSOCIATION: (5238.1) SUBSYSTEM: Aminosugar metabolism EC Number: 5.4.2.3 Confidence Level: 4 AUTHORS: PMID:11004509 NOTES:NCD
reversible: true
is version of: http://identifiers.org/ec-code/5.4.2.3
fast: false
type: Reaction
name: phosphoacetylglucosamine mutase
product: MODEL1310110045#
is described by: ECO:0000269
is: SBO:0000176
kinetic law: MODEL1310110045#
modifier: MODEL1310110045#

metaR H2Oter
fast: false
type: Reaction
reactant: MODEL1310110045#
product: MODEL1310110045#
kinetic law: MODEL1310110045#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD
is described by: ECO:0000000
reversible: true
is: SBO:0000185
name: H2O endoplasmic reticulum transport

http://identifiers.org/biomodels.db/MODEL1310110045#_4323e3e2_9a10_474f_a7cb_6b0001b10d62
boundary condition: true
is: Q9GZS9
initial amount: NaN
name: CHST5
is encoded by: hsa:23563
constant: false
type: Species
initial concentration: NaN
is: SBO:0000252
has only substance units: false

metaR r0083
fast: false
kinetic law: MODEL1310110045#
reversible: true
reactant: MODEL1310110045#
type: Reaction
name: Oxalosuccinate:NADP+ oxidoreductase (decarboxylating) Citrate cycle (TCA cycle) EC:1.1.1.42
is version of: http://identifiers.org/ec-code/1.1.1.42
product: MODEL1310110045#
is: SBO:0000176
is described by: ECO:0000000
modifier: MODEL1310110045#
notes: GENE_ASSOCIATION: (AI971036.1) or (3417.1) or (3418.1) SUBSYSTEM: Unassigned EC Number: 1.1.1.42 Confidence Level: 0 AUTHORS: PMID:16489927,PMID:9866202 NOTES:

metaR r2014
type: Reaction
reversible: false
product: MODEL1310110045#
is described by: ECO:0000000
modifier: MODEL1310110045#
reactant: MODEL1310110045#
kinetic law: MODEL1310110045#
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is: SBO:0000185
fast: false
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.15

http://identifiers.org/biomodels.db/MODEL1310110045#_e694ac26_7ac5_40f6_8e13_57bbbd73f842
type: Species
initial amount: NaN
is encoded by: hsa:AI191472
initial concentration: NaN
name: _AI191472_1_c
has only substance units: false
boundary condition: true
is: SBO:0000252
constant: false

http://identifiers.org/biomodels.db/MODEL1310110045#_9c1e4a23_c4fc_4c98_84ad_5fcbaa845526
initial concentration: NaN
name: AMY1A
type: Species
has only substance units: false
is encoded by: hsa:276
initial amount: NaN
is: SBO:0000252
boundary condition: true
is: Q6NSB3
constant: false

http://identifiers.org/biomodels.db/MODEL1310110045#_196e979e_7026_4779_a198_7a56f3283dde
boundary condition: true
type: Species
is: Q9NPH0
is: SBO:0000252
is encoded by: hsa:51205
name: ACP6
initial concentration: NaN
initial amount: NaN
constant: false
has only substance units: false

metaM ksi deg8 l
initial concentration: 1.0
has only substance units: false
initial amount: NaN
is: CHEBI:12936
is: HMDB00143
is: SBO:0000247
constant: false
name: keratan sulfate I, degradation product 8
notes: FORMULA: C194H311N13O171S10 CHARGE: -10
type: Species
boundary condition: false

metaR r0722
reversible: true
fast: false
is: SBO:0000176
product: MODEL1310110045#
name: (S)-3-Hydroxydodecanoyl-CoA:NAD+ oxidoreductase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:1.1.1.35 EC:1.1.1.211
is described by: ECO:0000000
kinetic law: MODEL1310110045#
reactant: MODEL1310110045#
modifier: MODEL1310110045#
type: Reaction
notes: GENE_ASSOCIATION: (5805.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.1.1.35 Confidence Level: 0 AUTHORS: PMID:10231530,PMID:10329704,PMID:1550553,PMID:1651711,PMID:7150615,PMID:8188243,PMID:8687463,PMID:9553139 NOTES:
is version of: http://identifiers.org/ec-code/4.2.3.12

metaR r0936
reversible: false
kinetic law: MODEL1310110045#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
fast: false
product: MODEL1310110045#
type: Reaction
reactant: MODEL1310110045#
is: SBO:0000185
is described by: ECO:0000000
name: Transport reaction

metaR CO2ter
name: CO2 endoplasmic reticular transport via diffusion
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD
kinetic law: MODEL1310110045#
fast: false
reactant: MODEL1310110045#
is described by: ECO:0000000
product: MODEL1310110045#
type: Reaction
is: SBO:0000185

metaM pa hs r
type: Species
is: SBO:0000247
initial concentration: 1.0
name: phosphatidate(2-)
initial amount: NaN
boundary condition: false
has only substance units: false
constant: false
is: CHEBI:57739
notes: FORMULA: C3H5O4PFULLRCO2FULLR2CO2 CHARGE: -2 EHMN_ABBREVIATION: C00416

http://identifiers.org/biomodels.db/MODEL1310110045#_fd366b79_a0e3_4946_9389_69e28debc248
is encoded by: hsa:6185
boundary condition: true
has only substance units: false
type: Species
is: P04844
name: RPN2
is: SBO:0000252
initial amount: NaN
initial concentration: NaN
constant: false

metaR EX CE1936 LPAREN e RPAREN
kinetic law: MODEL1310110045#
reactant: MODEL1310110045#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: spermine dialdehyde exchange
type: Reaction

metaR AG13T14g
is described by: ECO:0000000
name: N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase, Golgi apparatus
is: SBO:0000176
notes: GENE_ASSOCIATION: (79369.1) or (374907.1) or (11041.1) or (146712.1) or (374907.2) or (93010.1) or (10331.1) or (10678.1) or (10678.2) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.149 Confidence Level: 4 AUTHORS: PMID:10747980,PMID:11042166,PMID:12061784,PMID:12512857,PMID:15560372,PMID:15620693,PMID:9405606 NOTES:NCD
fast: false
type: Reaction
reactant: MODEL1310110045#
product: MODEL1310110045#
modifier: MODEL1310110045#
is version of: http://identifiers.org/ec-code/2.4.1.149
reversible: false
kinetic law: MODEL1310110045#

metaM gal1p c
name: (2R,3R,4S,5R,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl phosphate
boundary condition: false
type: Species
constant: false
is: SBO:0000247
initial concentration: 1.0
has only substance units: false
notes: FORMULA: C6H11O9P CHARGE: -2 INCHI: InChI=1S/C6H13O9P/c7-1-2-3(8)4(9)5(10)6(14-2)15-16(11,12)13/h2-10H,1H2,(H2,11,12,13)/p-2/t2-,3+,4+,5-,6-/m1/s1 EHMN_ABBREVIATION: C00446
initial amount: NaN
is: HMDB00645
is: CHEBI:58336

metaM glutcoa m
initial concentration: 1.0
name: glutaryl-CoA(5-)
boundary condition: false
notes: FORMULA: C26H37N7O19P3S CHARGE: -5 INCHI: InChI=1S/C26H42N7O19P3S/c1-26(2,21(39)24(40)29-7-6-15(34)28-8-9-56-17(37)5-3-4-16(35)36)11-49-55(46,47)52-54(44,45)48-10-14-20(51-53(41,42)43)19(38)25(50-14)33-13-32-18-22(27)30-12-31-23(18)33/h12-14,19-21,25,38-39H,3-11H2,1-2H3,(H,28,34)(H,29,40)(H,35,36)(H,44,45)(H,46,47)(H2,27,30,31)(H2,41,42,43)/p-5/t14-,19-,20-,21+,25-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00411 EHMN_ABBREVIATION: C00527
has only substance units: false
initial amount: NaN
is: CHEBI:57378
type: Species
is: SBO:0000247
constant: false
is: HMDB01339

http://identifiers.org/biomodels.db/MODEL1310110045#_2ca7a626_2dc8_4281_a493_2ee438a3931e
is: P00492
type: Species
is encoded by: hsa:3251
initial concentration: NaN
constant: false
boundary condition: true
has only substance units: false
initial amount: NaN
name: HPRT1
is: SBO:0000252

metaM C02528 r
name: chenodeoxycholate
type: Species
notes: FORMULA: C24H39O4 CHARGE: -1 INCHI: InChI=1S/C24H40O4/c1-14(4-7-21(27)28)17-5-6-18-22-19(9-11-24(17,18)3)23(2)10-8-16(25)12-15(23)13-20(22)26/h14-20,22,25-26H,4-13H2,1-3H3,(H,27,28)/p-1/t14-,15+,16-,17-,18+,19+,20-,22+,23+,24-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00958 EHMN_ABBREVIATION: C02528
constant: false
boundary condition: false
has only substance units: false
is: HMDB00518
is: CHEBI:36234
initial concentration: 1.0
is: SBO:0000247
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110045#_d5b51021_fa5b_4d9e_be58_79180196b258
type: Species
boundary condition: true
initial amount: NaN
is: Q86YN1
has only substance units: false
name: DOLPP1
initial concentration: NaN
is: SBO:0000252
constant: false
is encoded by: hsa:57171

metaR r0074
type: Reaction
kinetic law: MODEL1310110045#
reactant: MODEL1310110045#
is: SBO:0000176
reversible: true
is described by: ECO:0000000
name: L-Glutamate 5-semialdehyde:NAD+ oxidoreductase Arginine and proline metabolism EC:1.5.1.12
product: MODEL1310110045#
is version of: http://identifiers.org/ec-code/6.2.1.1
fast: false
notes: GENE_ASSOCIATION: (84532.1) or (55902.1) SUBSYSTEM: Urea cycle EC Number: 1.5.1.12 Confidence Level: 0 AUTHORS: PMID:1286669,PMID:2211729 NOTES:
modifier: MODEL1310110045#

metaR r0937
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
type: Reaction
name: Transport reaction
is described by: ECO:0000000
kinetic law: MODEL1310110045#
fast: false
product: MODEL1310110045#
reversible: true
reactant: MODEL1310110045#
is: SBO:0000185

metaR r1766
name: Y+LAT2 Utilized transport
reversible: false
kinetic law: MODEL1310110045#
reactant: MODEL1310110045#
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
fast: false
modifier: MODEL1310110045#
product: MODEL1310110045#
is: SBO:0000185
type: Reaction
is described by: ECO:0000000

metaR ATPtm
notes: GENE_ASSOCIATION: (291.1) or (293.1) or (292.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172 NOTES:NCD
product: MODEL1310110045#
reactant: MODEL1310110045#
is: SBO:0000185
is described by: ECO:0000269
type: Reaction
fast: false
kinetic law: MODEL1310110045#
name: ADP/ATP transporter, mitochondrial
modifier: MODEL1310110045#
reversible: false

metaR r1540
type: Reaction
product: MODEL1310110045#
reversible: false
reactant: MODEL1310110045#
is version of: http://identifiers.org/ec-code/1.17.4.1
is: SBO:0000185
name: Neurotransmitter:Sodium Symporter (NSS) TCDB:2.A.22.3.3
notes: GENE_ASSOCIATION: (BE966236.1) or (6240.1) or (6241.1) or (50484.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12719981 NOTES:
kinetic law: MODEL1310110045#
is described by: ECO:0000000
modifier: MODEL1310110045#
fast: false

http://identifiers.org/biomodels.db/MODEL1310110045#_a52886ec_192c_4140_a2ca_c1efe09a20a6
boundary condition: true
constant: false
is encoded by: hsa:55350
name: VNN3
type: Species
has only substance units: false
initial amount: NaN
is: SBO:0000252
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110045#_dc541ce9_7ea5_4248_84c5_b164476758f8
type: Species
boundary condition: true
name: _AA854479_1_m
initial amount: NaN
constant: false
has only substance units: false
is: SBO:0000252
initial concentration: NaN
is encoded by: hsa:AA854479

http://identifiers.org/biomodels.db/MODEL1310110045#_77492443_e25c_4c23_ad2c_6c29c29a972a
has only substance units: false
type: Species
boundary condition: true
is: SBO:0000252
is encoded by: hsa:501
initial amount: NaN
is: E7EPT3
initial concentration: NaN
constant: false
name: ALDH7A1

metaR r0720
product: MODEL1310110045#
fast: false
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.17 Confidence Level: 0 AUTHORS: PMID:8012501,PMID:8188243 NOTES:
kinetic law: MODEL1310110045#
reversible: false
is described by: ECO:0000000
reactant: MODEL1310110045#
name: (S)-3-Hydroxytetradecanoyl-CoA hydro-lyase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:4.2.1.17
type: Reaction

metaM asp L m
constant: false
is: SBO:0000247
boundary condition: false
initial concentration: 1.0
is: CHEBI:29991
notes: FORMULA: C4H6NO4 CHARGE: -1 INCHI: InChI=1S/C4H7NO4/c5-2(4(8)9)1-3(6)7/h2H,1,5H2,(H,6,7)(H,8,9)/p-1/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00055
type: Species
initial amount: NaN
has only substance units: false
name: L-aspartate(1-)
is: HMDB00191

metaR ETFQO
is described by: ECO:0000000
kinetic law: MODEL1310110045#
is version of: http://identifiers.org/ec-code/1.5.5.1
notes: GENE_ASSOCIATION: (2110.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.5.5.1 Confidence Level: 4 AUTHORS: PMID:10444348,PMID:12049629 NOTES:TV Ruzicka F, JBC, 1977
product: MODEL1310110045#
reactant: MODEL1310110045#
fast: false
modifier: MODEL1310110045#
is: SBO:0000176
type: Reaction
reversible: false
name: Electron transfer flavoprotein-ubiquinone oxidoreductase

metaM udpg r
initial amount: NaN
boundary condition: false
has only substance units: false
notes: FORMULA: C15H22N2O17P2 CHARGE: -2 INCHI: InChI=1S/C15H24N2O17P2/c18-3-5-8(20)10(22)12(24)14(32-5)33-36(28,29)34-35(26,27)30-4-6-9(21)11(23)13(31-6)17-2-1-7(19)16-15(17)25/h1-2,5-6,8-14,18,20-24H,3-4H2,(H,26,27)(H,28,29)(H,16,19,25)/p-2/t5-,6-,8-,9-,10+,11-,12-,13-,14?/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00038 EHMN_ABBREVIATION: C00029
is: HMDB00286
is: SBO:0000247
name: [(2R,3S,4R,5R)-5-(2,4-dioxo-1,2,3,4-tetrahydropyrimidin-1-yl)-3,4-dihydroxyoxolan-2-yl]methyl {[(3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl phosphonato]oxy}phosphonate
type: Species
initial concentration: 1.0
is: CHEBI:58367
constant: false

metaR RETH
notes: GENE_ASSOCIATION: (8228.1) SUBSYSTEM: Vitamin A metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:1503811,PMID:15955102 NOTES:IT
modifier: MODEL1310110045#
kinetic law: MODEL1310110045#
name: retinyl ester hydrolase
type: Reaction
is version of: http://identifiers.org/ec-code/3.1.1.3
is described by: ECO:0000000
fast: false
product: MODEL1310110045#
reversible: false
reactant: MODEL1310110045#
is: SBO:0000176

metaM pro D e
type: Species
is: SBO:0000247
name: D-proline
initial concentration: 1.0
notes: FORMULA: C5H9NO2 CHARGE: 0 INCHI: InChI=1S/C5H9NO2/c7-5(8)4-2-1-3-6-4/h4,6H,1-3H2,(H,7,8)/t4-/m1/s1
initial amount: NaN
constant: false
boundary condition: false
is: HMDB03411
has only substance units: false
is: CHEBI:16313

metaR ANTHte
fast: false
type: Reaction
kinetic law: MODEL1310110045#
name: Transport of anthranilate
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
reactant: MODEL1310110045#
is: SBO:0000185
product: MODEL1310110045#
is described by: ECO:0000134
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110045#_f8cb0fe7_0c73_414e_843c_176db92dd0b2
constant: false
type: Species
initial amount: NaN
name: BDH1
is encoded by: hsa:622
has only substance units: false
boundary condition: true
is: SBO:0000252
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110045#_61aa0264_1d5e_4ced_8650_230511083fad
initial amount: NaN
has only substance units: false
initial concentration: NaN
type: Species
is encoded by: hsa:549
is: SBO:0000252
is: Q13825
boundary condition: true
constant: false
name: AUH

metaR SGALSIDEtl
name: sgalside hs intracellular transport
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 1 AUTHORS: NOTES:unknown mechanism for transport - however must get to other intracellular compartments (e.g. lysosome for degradation) NJ
type: Reaction
is: SBO:0000185
reversible: true
fast: false
is described by: ECO:0000000
kinetic law: MODEL1310110045#
product: MODEL1310110045#
reactant: MODEL1310110045#

metaM pmtcrn r
is: CHEBI:17490
initial concentration: 1.0
constant: false
boundary condition: false
notes: FORMULA: C23H45NO4 CHARGE: 0 INCHI: InChI=1S/C23H45NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-23(27)28-21(19-22(25)26)20-24(2,3)4/h21H,5-20H2,1-4H3/t21-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01034 EHMN_ABBREVIATION: C02990
is: HMDB00222
is: SBO:0000247
type: Species
has only substance units: false
initial amount: NaN
name: L-palmitoylcarnitine

metaM srtn e
initial amount: NaN
constant: false
notes: FORMULA: C10H13N2O CHARGE: 1 INCHI: InChI=1S/C10H12N2O/c11-4-3-7-6-12-10-2-1-8(13)5-9(7)10/h1-2,5-6,12-13H,3-4,11H2/p+1 HEPATONET_1.0_ABBREVIATION: HC00533 EHMN_ABBREVIATION: C00780
type: Species
boundary condition: false
name: serotonin(1+)
is: HMDB00259
has only substance units: false
is: CHEBI:350546
initial concentration: 1.0
is: SBO:0000247

metaR CYSPHELAT2tc
kinetic law: MODEL1310110045#
product: MODEL1310110045#
reactant: MODEL1310110045#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of L-Cysteine into the cell and efflux of L-Phenylalanine out of the cell by LAT2 on the basolateral surfaces of kidney and intestine.
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110045#_defd1430_c0ba_4545_9431_b282838fee4a
boundary condition: true
is encoded by: hsa:AI697028
initial amount: NaN
has only substance units: false
is: SBO:0000252
type: Species
initial concentration: NaN
name: _AI697028_1_m
constant: false

metaM pap g
is: CHEBI:58343
is: HMDB00061
boundary condition: false
notes: FORMULA: C10H11N5O10P2 CHARGE: -4 INCHI: InChI=1S/C10H15N5O10P2/c11-8-5-9(13-2-12-8)15(3-14-5)10-6(16)7(25-27(20,21)22)4(24-10)1-23-26(17,18)19/h2-4,6-7,10,16H,1H2,(H2,11,12,13)(H2,17,18,19)(H2,20,21,22)/p-4/t4-,6-,7-,10-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00059 EHMN_ABBREVIATION: C00054
initial amount: NaN
initial concentration: 1.0
type: Species
name: adenosine 3',5'-bismonophosphate(4-)
has only substance units: false
is: SBO:0000247
constant: false

http://identifiers.org/biomodels.db/MODEL1310110045#_117faf24_1198_4669_8e1b_2f8415f489a7
is encoded by: hsa:3098
boundary condition: true
is: SBO:0000252
name: HK1
type: Species
is: A8K7J7
initial concentration: NaN
constant: false
initial amount: NaN
has only substance units: false

metaM apoC Lys c
notes: FORMULA: C6H13N2OX CHARGE: 0
initial concentration: 1.0
type: Species
is: CHEBI:32551
constant: false
has only substance units: false
boundary condition: false
name: Apocarboxylase (Lys residue)
is: HMDB00182
is: SBO:0000247
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110045#_8d5262ba_496f_4ffa_bbc9_e4b60e7cb12d
name: SLC26A1
type: Species
is: SBO:0000252
is: Q9H2B4
initial concentration: NaN
constant: false
initial amount: NaN
boundary condition: true
has only substance units: false
is encoded by: hsa:10861

http://identifiers.org/biomodels.db/MODEL1310110045#_8198f442_0e43_4025_a794_a7aad9325e69
initial amount: NaN
boundary condition: true
is encoded by: hsa:8503
type: Species
name: PIK3R3
initial concentration: NaN
is: SBO:0000252
constant: false
has only substance units: false
is: Q92569

metaR GALASE19ly
type: Reaction
kinetic law: MODEL1310110045#
name: beta-galactosidase, lysosomal
product: MODEL1310110045#
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) or (5476.1) and (2720.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.18 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD
modifier: MODEL1310110045#
is version of: http://identifiers.org/ec-code/3.1.6.4
fast: false
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.2.1.18
is version of: http://identifiers.org/ec-code/3.4.16.5
is described by: ECO:0000269
reversible: false
reactant: MODEL1310110045#
is version of: http://identifiers.org/ec-code/3.2.1.23

metaM prostgf2 c
notes: FORMULA: C20H33O5 CHARGE: -1 INCHI: InChI=1S/C20H34O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h4,7,12-13,15-19,21-23H,2-3,5-6,8-11,14H2,1H3,(H,24,25)/p-1/b7-4-,13-12+/t15-,16+,17+,18-,19+/m0/s1 EHMN_ABBREVIATION: C00639
initial amount: NaN
is: CHEBI:57404
is: SBO:0000247
has only substance units: false
is: HMDB01139
name: prostaglandin F2alpha(1-)
initial concentration: 1.0
type: Species
constant: false
boundary condition: false

metaM thcholstoic c
type: Species
notes: FORMULA: C27H45O5 CHARGE: -1 INCHI: InChI=1S/C27H46O5/c1-15(6-5-7-16(2)25(31)32)19-8-9-20-24-21(14-23(30)27(19,20)4)26(3)11-10-18(28)12-17(26)13-22(24)29/h15-24,28-30H,5-14H2,1-4H3,(H,31,32)/t15-,16?,17+,18-,19-,20+,21+,22-,23+,24+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01340 EHMN_ABBREVIATION: C04722
initial concentration: 1.0
has only substance units: false
name: 3alpha,7alpha,12alpha-Trihydroxy-5beta-cholestanoate
boundary condition: false
is: CHEBI:18402
initial amount: NaN
constant: false
is: HMDB03873
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110045#_446073f3_a122_41cd_adc6_365f8d225068
has part: P13804
initial amount: NaN
is encoded by: hsa:2108
constant: false
type: Species
is encoded by: hsa:2109
initial concentration: NaN
name: ETFA:ETFB
boundary condition: true
is: SBO:0000297
has only substance units: false

metaR PSFLIPm
product: MODEL1310110045#
is: SBO:0000185
name: phosphatidylserine flippase
fast: false
modifier: MODEL1310110045#
is described by: ECO:0000269
kinetic law: MODEL1310110045#
notes: GENE_ASSOCIATION: (10396.1) or (57194.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:10198212,PMID:10856717,PMID:11353404 NOTES:See PMID: 10856717 - flippase activity no detailed data on which compartment ATP hydrolysis occurs, so for the time being assumed to be cytosolic NJ
reactant: MODEL1310110045#
type: Reaction
is version of: http://identifiers.org/ec-code/3.6.3.1
reversible: false

metaM Asn X Ser Thr r
notes: FORMULA: XH CHARGE: 0
name: protein-linked asparagine residue (N-glycosylation site)
is: C01342
is: CHEBI:28938
has only substance units: false
is: HMDB00051
boundary condition: false
type: Species
initial concentration: 1.0
is: SBO:0000247
initial amount: NaN
constant: false

metaR CYANt
is described by: ECO:0000000
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:assumed to be readily diffusible MM
kinetic law: MODEL1310110045#
product: MODEL1310110045#
is: SBO:0000185
fast: false
reversible: true
name: Cyanide transport via diffusion (extracellular to cytosol)
reactant: MODEL1310110045#

http://identifiers.org/biomodels.db/MODEL1310110045#_9610d416_ecf7_41b4_8f66_eed76b18608a
constant: false
name: GMDS
is encoded by: hsa:2762
is: O60547
type: Species
initial concentration: NaN
is: SBO:0000252
has only substance units: false
boundary condition: true
initial amount: NaN

metaR H2Otly
fast: false
product: MODEL1310110045#
reactant: MODEL1310110045#
kinetic law: MODEL1310110045#
is described by: ECO:0000000
is: SBO:0000185
reversible: true
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD
name: H2O transport, lysosomal

metaR DUMPtn
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: NOTES:NCD
name: dUMP nuclear transport
is described by: ECO:0000000
reactant: MODEL1310110045#
kinetic law: MODEL1310110045#
type: Reaction
reversible: true
is: SBO:0000185
product: MODEL1310110045#

metaR CYTK10n
fast: false
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/2.7.4.14
modifier: MODEL1310110045#
reversible: true
kinetic law: MODEL1310110045#
reactant: MODEL1310110045#
product: MODEL1310110045#
is: SBO:0000176
name: cytidylate kinase (CMP,dGTP),nuclear
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
type: Reaction

metaM acgam6p c
boundary condition: false
type: Species
has only substance units: false
is: SBO:0000247
constant: false
initial amount: NaN
notes: FORMULA: C8H14NO9P CHARGE: -2 INCHI: InChI=1S/C8H16NO9P/c1-3(10)9-5-7(12)6(11)4(18-8(5)13)2-17-19(14,15)16/h4-8,11-13H,2H2,1H3,(H,9,10)(H2,14,15,16)/p-2/t4-,5-,6-,7-,8?/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00303 EHMN_ABBREVIATION: C00357
is: HMDB01062
is: CHEBI:57513
name: N-acetyl-D-glucosamine 6-phosphate(2-)
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110045#_2dd7206c_6371_4648_865e_2ebd0356b9d8
is: SBO:0000252
boundary condition: true
is encoded by: hsa:23428
type: Species
name: SLC7A8
is: Q86U05
initial concentration: NaN
has only substance units: false
initial amount: NaN
constant: false

metaM lys L m
initial amount: NaN
has only substance units: false
initial concentration: 1.0
is: CHEBI:32551
notes: FORMULA: C6H15N2O2 CHARGE: 1 INCHI: InChI=1S/C6H14N2O2/c7-4-2-1-3-5(8)6(9)10/h5H,1-4,7-8H2,(H,9,10)/p+1/t5-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00053 EHMN_ABBREVIATION: C00047
type: Species
is: SBO:0000247
is: HMDB00182
boundary condition: false
name: L-lysinium(1+)
constant: false

metaR EX ump LPAREN e RPAREN
kinetic law: MODEL1310110045#
reactant: MODEL1310110045#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: UMP exchange
type: Reaction

metaM oaa x
type: Species
constant: false
is: SBO:0000247
name: Oxaloacetate
initial amount: NaN
initial concentration: 1.0
is: HMDB00223
is: CHEBI:16452
boundary condition: false
has only substance units: false
is: C00036
notes: FORMULA: C4H2O5 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00044 EHMN_ABBREVIATION: C00036

metaR DOPASFt
reversible: false
reactant: MODEL1310110045#
product: MODEL1310110045#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 1 AUTHORS: NOTES:SAB excretion of dopamine sulfate
name: Dopamine 3-0-sulfate transport (diffusion)
is: SBO:0000185
kinetic law: MODEL1310110045#
type: Reaction
fast: false

metaR r1454
is described by: ECO:0000000
fast: false
type: Reaction
reactant: MODEL1310110045#
product: MODEL1310110045#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:17603022,PMID:6240978,PMID:7876265 NOTES:
kinetic law: MODEL1310110045#
name: TCDB:2.A.1.13.5 TCDB:2.A.1.13.1
is: SBO:0000185
reversible: false

metaR FUMSO3tm
is: SBO:0000185
notes: GENE_ASSOCIATION: (1468.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172,PMID:4441366 NOTES:MM
name: Fumarate:sulfite antiport, mitochondrial
modifier: MODEL1310110045#
reactant: MODEL1310110045#
kinetic law: MODEL1310110045#
type: Reaction
is described by: ECO:0000269
fast: false
reversible: true
product: MODEL1310110045#

metaM ethamp r
initial amount: NaN
initial concentration: 1.0
is: CHEBI:58190
boundary condition: false
type: Species
has only substance units: false
is: HMDB00224
constant: false
name: O-phosphonatoethanaminium(1-)
notes: FORMULA: C2H7NO4P CHARGE: -1 INCHI: InChI=1S/C2H8NO4P/c3-1-2-7-8(4,5)6/h1-3H2,(H2,4,5,6)/p-1 HEPATONET_1.0_ABBREVIATION: HC00293 EHMN_ABBREVIATION: C00346
is: SBO:0000247

metaR SGALSIDEtg
name: sgalside hs intracellular transport
reactant: MODEL1310110045#
product: MODEL1310110045#
is: SBO:0000185
fast: false
is described by: ECO:0000000
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 1 AUTHORS: NOTES:unknown mechanism for transport - however must get to other intracellular compartments (e.g. lysosome for degradation) NJ
kinetic law: MODEL1310110045#
reversible: true

metaR PUNP7
reactant: MODEL1310110045#
product: MODEL1310110045#
notes: GENE_ASSOCIATION: (4860.1) SUBSYSTEM: Nucleotide interconversion EC Number: 3.4.2.1 Confidence Level: 4 AUTHORS: PMID:6087295,PMID:9305963 NOTES:Specificity not completely determined. Can also catalyse ribosyltransferase reactions of the type catalysed by EC 2.4.2.5, nucleoside ribosyltransferasextsn
kinetic law: MODEL1310110045#
is: SBO:0000176
modifier: MODEL1310110045#
reversible: true
fast: false
name: purine-nucleoside phosphorylase (Xanthosine)
is version of: http://identifiers.org/ec-code/2.4.2.1
type: Reaction
is described by: ECO:0000269

metaR RE0688E
name: RE0688
reversible: false
modifier: MODEL1310110045#
is version of: http://identifiers.org/ec-code/1.4.3.22
fast: false
kinetic law: MODEL1310110045#
reactant: MODEL1310110045#
type: Reaction
notes: GENE_ASSOCIATION: (26.1) SUBSYSTEM: Urea cycle EC Number: 1.4.3.6 Confidence Level: 0 AUTHORS: PMID:10047787,PMID:7040832 NOTES:
is described by: ECO:0000000
is: SBO:0000176
product: MODEL1310110045#

metaM oxa x
constant: false
name: oxalate(2-)
is: HMDB02329
is: CHEBI:30623
notes: FORMULA: C2O4 CHARGE: -2 INCHI: InChI=1S/C2H2O4/c3-1(4)2(5)6/h(H,3,4)(H,5,6)/p-2 HEPATONET_1.0_ABBREVIATION: HC00195 EHMN_ABBREVIATION: C00209
type: Species
has only substance units: false
initial concentration: 1.0
initial amount: NaN
boundary condition: false
is: SBO:0000247

metaR BTNPL
product: MODEL1310110045#
name: holocarboxylase synthestase (biotin protein ligase)
notes: GENE_ASSOCIATION: (3141.1) SUBSYSTEM: Biotin metabolism EC Number: Confidence Level: 4 AUTHORS: NOTES:IT for human biotin metabolism
type: Reaction
is described by: ECO:0000000
fast: false
modifier: MODEL1310110045#
reactant: MODEL1310110045#
is version of: http://identifiers.org/ec-code/6.3.4.10
is: SBO:0000176
kinetic law: MODEL1310110045#
reversible: false

metaR SAMHISTA
is: SBO:0000176
fast: false
product: MODEL1310110045#
notes: GENE_ASSOCIATION: (3176.1) SUBSYSTEM: Histidine metabolism EC Number: 2.1.1.8 Confidence Level: 4 AUTHORS: PMID:7943261 NOTES:SAB R02155
type: Reaction
reactant: MODEL1310110045#
reversible: false
is described by: ECO:0000269
name: S-Adenosyl-L-methionine:histamine N-tele-methyltransferase
modifier: MODEL1310110045#
kinetic law: MODEL1310110045#
is version of: http://identifiers.org/ec-code/2.1.1.8

metaR MALSO3tm
name: Malate:sulfite antiport, mitochondrial
product: MODEL1310110045#
type: Reaction
fast: false
kinetic law: MODEL1310110045#
modifier: MODEL1310110045#
reactant: MODEL1310110045#
is: SBO:0000185
reversible: true
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (1468.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172,PMID:4441366 NOTES:MM

metaR r1453
is described by: ECO:0000000
type: Reaction
is: SBO:0000176
product: MODEL1310110045#
fast: false
reactant: MODEL1310110045#
reversible: true
name: L-proline:(acceptor) oxidoreductase Arginine and proline metabolism EC:1.5.99.8
kinetic law: MODEL1310110045#
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: Confidence Level: 0 AUTHORS: PMID:18506409 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110045#_18f63183_a5ca_4b82_9882_1e3aba1fc64d
constant: false
is: SBO:0000252
type: Species
initial amount: NaN
has only substance units: false
initial concentration: NaN
is encoded by: hsa:6390
boundary condition: true
is: P21912
name: SDHB

metaR RE1522M
type: Reaction
fast: false
is version of: http://identifiers.org/ec-code/4.2.1.17
is version of: http://identifiers.org/ec-code/2.3.1.16
product: MODEL1310110045#
modifier: MODEL1310110045#
notes: GENE_ASSOCIATION: (1892.1) or (3030.1) or (1962.1) or (3032.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.17 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:7775433,PMID:7923814,PMID:9568246,PMID:9920399 NOTES:
is described by: ECO:0000000
is: SBO:0000176
name: RE1522
kinetic law: MODEL1310110045#
is version of: http://identifiers.org/ec-code/1.1.1.35
reversible: true
reactant: MODEL1310110045#

http://identifiers.org/biomodels.db/MODEL1310110045#_55fe1ced_b03f_4d15_91d7_bf6ae6d8beb8
initial amount: NaN
type: Species
is: SBO:0000252
initial concentration: NaN
is encoded by: hsa:AI990637
constant: false
name: _AI990637_1_x
boundary condition: true
has only substance units: false

metaR EX pi LPAREN e RPAREN
kinetic law: MODEL1310110045#
reactant: MODEL1310110045#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Phosphate exchange
type: Reaction

metaM dtdp c
is: C00363
is: HMDB01274
initial amount: NaN
name: dTDP
constant: false
boundary condition: false
initial concentration: 1.0
type: Species
is: CHEBI:58369
has only substance units: false
is: SBO:0000247
notes: FORMULA: C10H13N2O11P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00307 EHMN_ABBREVIATION: C00363

metaM dolglcp L c
has only substance units: false
initial concentration: 1.0
notes: FORMULA: C1140H1868O90P10 CHARGE: -10 INCHI: InChI=1S/C31H55O9P/c1-22(2)11-7-12-23(3)13-8-14-24(4)15-9-16-25(5)17-10-18-26(6)19-20-38-41(36,37)40-31-30(35)29(34)28(33)27(21-32)39-31/h11,13,15,17,26-35H,7-10,12,14,16,18-21H2,1-6H3,(H,36,37)/b23-13+,24-15+,25-17-/t26?,27-,28-,29+,30-,31+/m1/s1
boundary condition: false
is: CHEBI:15812
name: Dolichyl beta-D-glucosyl phosphate, human liver homolog
type: Species
initial amount: NaN
is: SBO:0000247
constant: false

http://identifiers.org/biomodels.db/MODEL1310110045#_5716f0a7_a7b7_4b42_9fb7_5e825db21f38
name: MIA3
initial concentration: NaN
constant: false
initial amount: NaN
boundary condition: true
type: Species
is: SBO:0000252
has only substance units: false
is encoded by: hsa:375056
is: Q5JRA6

metaR r0156
type: Reaction
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/2.7.1.40
name: L-Glutamine:pyruvate aminotransferase Glutamate metabolism EC:2.6.1.15
fast: false
kinetic law: MODEL1310110045#
reversible: false
reactant: MODEL1310110045#
product: MODEL1310110045#
is: SBO:0000176
notes: GENE_ASSOCIATION: (H77542.1) or (5313.1) or (5315.1) SUBSYSTEM: Urea cycle EC Number: 2.6.1.15 Confidence Level: 0 AUTHORS: PMID:12850267,PMID:1296212,PMID:3003500,PMID:4762917,PMID:4797019,PMID:4822504,PMID:5059882 NOTES:
modifier: MODEL1310110045#

metaR PCHOLP hs
modifier: MODEL1310110045#
is described by: ECO:0000269
name: choline phosphatase
fast: false
reversible: false
is version of: http://identifiers.org/ec-code/3.1.4.4
kinetic law: MODEL1310110045#
type: Reaction
reactant: MODEL1310110045#
notes: GENE_ASSOCIATION: (5338.1) SUBSYSTEM: Glycerophospholipid metabolism EC Number: 3.1.4.4 Confidence Level: 4 AUTHORS: PMID:9395408,PMID:9582313 NOTES:NJ
is: SBO:0000176
product: MODEL1310110045#

metaR COAtm
name: CoA transporter
is: SBO:0000185
reactant: MODEL1310110045#
is described by: ECO:0000269
product: MODEL1310110045#
notes: GENE_ASSOCIATION: (8034.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172 NOTES:TV May not a "real" transporter, use in heart mitochondria model only
kinetic law: MODEL1310110045#
fast: false
reversible: true
modifier: MODEL1310110045#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110045#_52186f81_0dc6_49c8_a3b8_b1d9a03e57ab
initial amount: NaN
boundary condition: true
initial concentration: NaN
constant: false
has only substance units: false
is: Q8NFM4
name: ADCY4
is encoded by: hsa:196883
type: Species
is: SBO:0000252

metaR ORNDC
modifier: MODEL1310110045#
type: Reaction
is: SBO:0000176
product: MODEL1310110045#
notes: GENE_ASSOCIATION: (4953.1) SUBSYSTEM: Urea cycle EC Number: 4.1.1.17 Confidence Level: 4 AUTHORS: PMID:2317811 NOTES:JLR- added proton to balance
is version of: http://identifiers.org/ec-code/4.1.1.17
reversible: false
kinetic law: MODEL1310110045#
fast: false
reactant: MODEL1310110045#
name: Ornithine Decarboxylase
is described by: ECO:0000269

metaM HC02202 e
type: Species
is: CHEBI:57398
constant: false
is: SBO:0000247
initial amount: NaN
boundary condition: false
has only substance units: false
initial concentration: 1.0
name: prostaglandin A1(1-)
notes: FORMULA: C20H31O4 CHARGE: -1 INCHI: InChI=1S/C20H32O4/c1-2-3-6-9-17(21)14-12-16-13-15-19(22)18(16)10-7-4-5-8-11-20(23)24/h12-18,21H,2-11H2,1H3,(H,23,24)/p-1/b14-12+/t16-,17-,18+/m0/s1 EHMN_ABBREVIATION: C04685

http://identifiers.org/biomodels.db/MODEL1310110045#_08e896c9_1417_447a_a289_17257bfff25b
constant: false
initial amount: NaN
name: ETFB
has only substance units: false
boundary condition: true
is: P38117
is encoded by: hsa:2109
is: SBO:0000252
type: Species
initial concentration: NaN

metaR r0157
reactant: MODEL1310110045#
notes: GENE_ASSOCIATION: (AA502753.1) or (1503.1) or (56474.1) SUBSYSTEM: Urea cycle EC Number: 2.6.1.15 Confidence Level: 0 AUTHORS: PMID:12850267,PMID:1296212,PMID:3003500,PMID:4762917,PMID:4797019,PMID:4822504,PMID:5059882 NOTES:
product: MODEL1310110045#
name: L-Glutamine:pyruvate aminotransferase Glutamate metabolism EC:2.6.1.15
is version of: http://identifiers.org/ec-code/6.3.4.2
is: SBO:0000176
modifier: MODEL1310110045#
type: Reaction
fast: false
is described by: ECO:0000000
kinetic law: MODEL1310110045#
reversible: false

metaM dtdp e
is: CHEBI:58369
boundary condition: false
is: SBO:0000247
initial amount: NaN
notes: FORMULA: C10H13N2O11P2 CHARGE: -3 INCHI: InChI=1S/C10H16N2O11P2/c1-5-3-12(10(15)11-9(5)14)8-2-6(13)7(22-8)4-21-25(19,20)23-24(16,17)18/h3,6-8,13H,2,4H2,1H3,(H,19,20)(H,11,14,15)(H2,16,17,18)/p-3/t6-,7+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00307 EHMN_ABBREVIATION: C00363
type: Species
constant: false
initial concentration: 1.0
is: HMDB01274
has only substance units: false
name: ({[(2R,3S,5R)-3-hydroxy-5-(5-methyl-2,4-dioxo-1,2,3,4-tetrahydropyrimidin-1-yl)oxolan-2-yl]methyl phosphonato}oxy)phosphonate

metaR COAtn
fast: false
name: coenzyme A transport, nuclear
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: NOTES:NCD
reversible: true
is: SBO:0000185
reactant: MODEL1310110045#
type: Reaction
is described by: ECO:0000000
product: MODEL1310110045#
kinetic law: MODEL1310110045#

metaM ksi pre28 g
is: SBO:0000247
is: C00130
has only substance units: false
is: HMDB00175
initial amount: NaN
constant: false
is: CHEBI:58053
notes: FORMULA: C213H341N15O176S8X CHARGE: -9
type: Species
boundary condition: false
name: keratan sulfate I biosynthesis, precursor 28
initial concentration: 1.0

metaR EX glc LPAREN e RPAREN
kinetic law: MODEL1310110045#
reactant: MODEL1310110045#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: D-Glucose exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110045#_3dfeb5db_e2f2_49fa_9459_f6b14e9459ef
constant: false
has only substance units: false
initial concentration: NaN
type: Species
is encoded by: hsa:5052
name: PRDX1
is: SBO:0000252
boundary condition: true
initial amount: NaN

metaM pmtcrn x
is: CHEBI:17490
is: SBO:0000247
has only substance units: false
initial amount: NaN
notes: FORMULA: C23H45NO4 CHARGE: 0 INCHI: InChI=1S/C23H45NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-23(27)28-21(19-22(25)26)20-24(2,3)4/h21H,5-20H2,1-4H3/t21-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01034 EHMN_ABBREVIATION: C02990
name: L-palmitoylcarnitine
constant: false
initial concentration: 1.0
type: Species
is: HMDB00222
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110045#_c80fa442_a2bb_4345_9032_8ea97bc4ef5c
type: Species
has only substance units: false
initial amount: NaN
boundary condition: true
initial concentration: NaN
constant: false
is: SBO:0000252
is encoded by: hsa:F23536
name: _F23536_1_m

metaM dece3coa m
boundary condition: false
initial concentration: 1.0
name: 3-decenoylcoa
constant: false
is: http://identifiers.org/pubchem.compound/16019966
notes: FORMULA: C31H48N7O17P3S CHARGE: -4
has only substance units: false
type: Species
is: SBO:0000247
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110045#_0c1d0cd0_2523_4c44_adba_1dfdc805f158
initial concentration: NaN
has only substance units: false
type: Species
initial amount: NaN
is: SBO:0000252
name: GPX1
boundary condition: true
is encoded by: hsa:2876
constant: false

http://identifiers.org/biomodels.db/MODEL1310110045#_d69854b8_c7ef_434f_b7ae_f2414ad21e03
constant: false
is encoded by: hsa:160728
is: SBO:0000252
has only substance units: false
name: SLC5A8
initial concentration: NaN
boundary condition: true
is: Q8N695
type: Species
initial amount: NaN

metaM HC01399 m
constant: false
name: (S)-3-Hydroxytetradecanoyl-CoA
has only substance units: false
initial amount: NaN
is: CHEBI:27466
type: Species
boundary condition: false
initial concentration: 1.0
notes: FORMULA: C35H58N7O18P3S CHARGE: -4 INCHI: InChI=1S/C35H62N7O18P3S/c1-4-5-6-7-8-9-10-11-12-13-23(43)18-26(45)64-17-16-37-25(44)14-15-38-33(48)30(47)35(2,3)20-57-63(54,55)60-62(52,53)56-19-24-29(59-61(49,50)51)28(46)34(58-24)42-22-41-27-31(36)39-21-40-32(27)42/h21-24,28-30,34,43,46-47H,4-20H2,1-3H3,(H,37,44)(H,38,48)(H,52,53)(H,54,55)(H2,36,39,40)(H2,49,50,51)/t23-,24+,28+,29+,30-,34+/m0/s1 EHMN_ABBREVIATION: C05260
is: SBO:0000247

metaM btamp m
is: HMDB04220
name: Biotinyl-5'-AMP
initial amount: NaN
boundary condition: false
notes: FORMULA: C20H27N7O9PS CHARGE: -1 INCHI: InChI=1S/C20H28N7O9PS/c21-17-14-18(23-7-22-17)27(8-24-14)19-16(30)15(29)10(35-19)5-34-37(32,33)36-12(28)4-2-1-3-11-13-9(6-38-11)25-20(31)26-13/h7-11,13,15-16,19,29-30H,1-6H2,(H,32,33)(H2,21,22,23)(H2,25,26,31)/t9-,10+,11-,13-,15+,16+,19+/m0/s1 EHMN_ABBREVIATION: C05921
initial concentration: 1.0
is: CHEBI:3110
constant: false
is: SBO:0000247
has only substance units: false
type: Species

metaR APAT2rm
name: 3-Aminopropanoate:2-oxoglutarate aminotransferase (m)
notes: GENE_ASSOCIATION: (18.1) or (18.2) SUBSYSTEM: beta-Alanine metabolism EC Number: 2.6.19.4 Confidence Level: 1 AUTHORS: PMID:15304357 NOTES:SAB
product: MODEL1310110045#
is: SBO:0000176
kinetic law: MODEL1310110045#
reactant: MODEL1310110045#
fast: false
modifier: MODEL1310110045#
is version of: http://identifiers.org/ec-code/2.6.1.19
is described by: ECO:0000212
reversible: true
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110045#_a7705a5f_b7a6_45ee_8809_2060133a2aa2
has only substance units: false
initial concentration: NaN
is: P50747
type: Species
is encoded by: hsa:3141
initial amount: NaN
boundary condition: true
constant: false
is: SBO:0000252
name: HLCS

metaR SIAASE3ly
is described by: ECO:0000000
product: MODEL1310110045#
modifier: MODEL1310110045#
is version of: http://identifiers.org/ec-code/3.2.1.23
kinetic law: MODEL1310110045#
is version of: http://identifiers.org/ec-code/3.2.1.18
reactant: MODEL1310110045#
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.18 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD
type: Reaction
fast: false
reversible: false
is version of: http://identifiers.org/ec-code/3.1.6.4
is: SBO:0000176
name: sialidase, lysosomal
is version of: http://identifiers.org/ec-code/3.4.16.5

metaM n2m2nmn l
is: HMDB00123
is: CHEBI:15428
is: SBO:0000247
initial concentration: 1.0
notes: FORMULA: C50H84N4O36 CHARGE: 0
has only substance units: false
boundary condition: false
constant: false
type: Species
name: reducing GlcNAc removed form of n2m2nmasn (w/o peptide)
initial amount: NaN

metaR 4NPHte
name: xenobiotic transport
kinetic law: MODEL1310110045#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:8385949,PMID:9219629 NOTES:unknown mechanism, related cyp P450 metabolism reactions NJ. Physiological, Rat
reversible: true
fast: false
type: Reaction
is: SBO:0000185
is described by: ECO:0000000
reactant: MODEL1310110045#
product: MODEL1310110045#

metaM HC02202 c
type: Species
is: CHEBI:57398
constant: false
is: SBO:0000247
has only substance units: false
boundary condition: false
initial concentration: 1.0
initial amount: NaN
name: prostaglandin A1(1-)
notes: FORMULA: C20H31O4 CHARGE: -1 INCHI: InChI=1S/C20H32O4/c1-2-3-6-9-17(21)14-12-16-13-15-19(22)18(16)10-7-4-5-8-11-20(23)24/h12-18,21H,2-11H2,1H3,(H,23,24)/p-1/b14-12+/t16-,17-,18+/m0/s1 EHMN_ABBREVIATION: C04685

http://identifiers.org/biomodels.db/MODEL1310110045#_75085f46_844b_4cc8_a240_da6fce96a98d
is encoded by: hsa:84569
is: SBO:0000252
has only substance units: false
type: Species
constant: false
name: LYZL1
is: Q6UWQ5
initial amount: NaN
boundary condition: true
initial concentration: NaN

metaM m6mpdol L r
boundary condition: false
has only substance units: false
notes: FORMULA: C1660H2728N20O520P20 CHARGE: -20
constant: false
name: (alpha-D-Mannosyl)6-beta-D-mannosyl-diacetylchitobiosyldiphosphodolichol, human liver homolog
is: CHEBI:37635
initial amount: NaN
initial concentration: 1.0
type: Species
is: SBO:0000247

metaM CE4792 m
notes: FORMULA: C35H54N7O18P3S CHARGE: -4 INCHI: InChI=1/C35H58N7O18P3S/c1-4-5-6-7-8-9-10-11-12-13-23(43)18-26(45)64-17-16-37-25(44)14-15-38-33(48)30(47)35(2,3)20-57-63(54,55)60-62(52,53)56-19-24-29(59-61(49,50)51)28(46)34(58-24)42-22-41-27-31(36)39-21-40-32(27)42/h8-9,21-22,24,28-30,34,46-47H,4-7,10-20H2,1-3H3,(H,37,44)(H,38,48)(H,52,53)(H,54,55)(H2,36,39,40)(H2,49,50,51)/p-4/b9-8-/t24-,28+,29+,30u,34-/m0/s1 EHMN_ABBREVIATION: CE4792
is: SBO:0000247
name: 3-oxo-cis-8-tetradecenoyl-CoA
initial amount: NaN
has only substance units: false
boundary condition: false
initial concentration: 1.0
constant: false
is: CHEBI:57923
type: Species

http://identifiers.org/biomodels.db/MODEL1310110045#_30c18055_ac1d_4ff0_894f_96f4e18603c2
has only substance units: false
name: SLC16A7
boundary condition: true
initial amount: NaN
is encoded by: hsa:9194
initial concentration: NaN
is: SBO:0000252
constant: false
is: Q8NEM3
type: Species

metaM Asn X Ser Thr l
has only substance units: false
initial amount: NaN
name: protein-linked asparagine residue (N-glycosylation site)
is: CHEBI:28938
is: HMDB00051
initial concentration: 1.0
is: C01342
is: SBO:0000247
boundary condition: false
notes: FORMULA: XH CHARGE: 0
type: Species
constant: false

metaR G14T12g
reversible: false
reactant: MODEL1310110045#
modifier: MODEL1310110045#
notes: GENE_ASSOCIATION: (8703.1) or (2683.1) or (8704.2) or (8704.1) or (9334.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.38 Confidence Level: 4 AUTHORS: PMID:12512857,PMID:1903938,PMID:3094506,PMID:3144273,PMID:9405390,PMID:9435216 NOTES:Keratan sulfate I biosynthesis NCD
name: beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase, Golgi
is version of: http://identifiers.org/ec-code/2.4.1.38
kinetic law: MODEL1310110045#
is version of: http://identifiers.org/ec-code/2.4.1.22
is described by: ECO:0000000
fast: false
product: MODEL1310110045#
is version of: http://identifiers.org/ec-code/2.4.1.90
is: SBO:0000176
type: Reaction

metaM pa hs m
type: Species
boundary condition: false
constant: false
is: CHEBI:57739
initial amount: NaN
has only substance units: false
initial concentration: 1.0
notes: FORMULA: C3H5O4PFULLRCO2FULLR2CO2 CHARGE: -2 EHMN_ABBREVIATION: C00416
is: SBO:0000247
name: phosphatidate(2-)

metaM prostge1 c
notes: FORMULA: C20H33O5 CHARGE: -1 INCHI: InChI=1S/C20H34O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h12-13,15-17,19,21,23H,2-11,14H2,1H3,(H,24,25)/p-1/b13-12+/t15-,16+,17+,19+/m0/s1 EHMN_ABBREVIATION: C04741
initial concentration: 1.0
initial amount: NaN
type: Species
is: HMDB01442
boundary condition: false
name: prostaglandin E1(1-)
constant: false
is: SBO:0000247
has only substance units: false
is: CHEBI:57397

http://identifiers.org/biomodels.db/MODEL1310110045#_962fbb10_58ae_45d6_a2cd_d9ea534ceb6a
has only substance units: false
name: PANK4
is encoded by: hsa:55229
constant: false
initial concentration: NaN
type: Species
is: Q9NVE7
boundary condition: true
initial amount: NaN
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110045#_2e2e1e5b_8790_401e_92ac_0b387020d63a
name: HMGCS2
boundary condition: true
constant: false
is: P54868
is encoded by: hsa:3158
is: SBO:0000252
has only substance units: false
initial amount: NaN
type: Species
initial concentration: NaN

metaR ACACtx
reversible: true
is described by: ECO:0000000
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 1 AUTHORS: NOTES:unknown mechanism NJ
product: MODEL1310110045#
fast: false
is: SBO:0000185
kinetic law: MODEL1310110045#
reactant: MODEL1310110045#
name: acetoacetate intracellular transport unknown mechanism

http://identifiers.org/biomodels.db/MODEL1310110045#_bf8ceba2_fa41_4817_96be_0c87bf06b528
initial concentration: NaN
constant: false
is: SBO:0000252
is: B7Z6S1
is encoded by: hsa:2629
has only substance units: false
boundary condition: true
initial amount: NaN
type: Species
name: GBA

http://identifiers.org/biomodels.db/MODEL1310110045#_ffcbbf28_36fb_478f_a698_098aca5c21fe
is: SBO:0000252
initial concentration: NaN
name: DHCR7
boundary condition: true
constant: false
has only substance units: false
type: Species
is encoded by: hsa:1717
is: Q9UBM7
initial amount: NaN

metaR 4ABUTtcn
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 1 AUTHORS: Jane D. Carver, W. Allan Walkera , The Journal of Nutritional Biochemistry, Volume 6, Issue 2, February 1995, Pages 58?72. NOTES:added during gap-filling, required for GABA role in cell proliferation.
type: Reaction
reversible: false
reactant: MODEL1310110045#
is: SBO:0000185
name: transport of GABA
kinetic law: MODEL1310110045#
is described by: ECO:0000134
product: MODEL1310110045#
fast: false

http://identifiers.org/biomodels.db/MODEL1310110045#_b1a269d3_9297_4e97_b9a2_ec91a8f76f4f
name: PDE8A
is: SBO:0000252
is encoded by: hsa:5151
initial amount: NaN
has only substance units: false
initial concentration: NaN
boundary condition: true
constant: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110045#_975293c7_33d6_446f_8c32_9a4028976576
is: Q9UBK5
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:10870
is: SBO:0000252
type: Species
name: HCST
has only substance units: false
constant: false
boundary condition: true

metaM apoC Lys m
is: HMDB00182
has only substance units: false
boundary condition: false
initial amount: NaN
name: Apocarboxylase (Lys residue)
initial concentration: 1.0
is: SBO:0000247
type: Species
is: CHEBI:32551
notes: FORMULA: C6H13N2OX CHARGE: 0
constant: false

http://identifiers.org/biomodels.db/MODEL1310110045#_de3f3b27_6e08_4988_88d9_e1c64284ef44
constant: false
is: SBO:0000252
name: ADH4
is: P08319
initial amount: NaN
initial concentration: NaN
type: Species
is encoded by: hsa:127
boundary condition: true
has only substance units: false

metaR ABUTt2r
reversible: true
reactant: MODEL1310110045#
type: Reaction
name: 4-aminobutyrate reversible transport in via proton symport
is: SBO:0000185
modifier: MODEL1310110045#
fast: false
kinetic law: MODEL1310110045#
is described by: ECO:0000304
notes: GENE_ASSOCIATION: (206358.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11390972,PMID:11959859 NOTES:SAB r
product: MODEL1310110045#

http://identifiers.org/biomodels.db/MODEL1310110045#_b6e0d5c9_512f_430e_8ecc_1ecd1c80413f
type: Species
initial concentration: NaN
is encoded by: hsa:AA081045
has only substance units: false
constant: false
is: SBO:0000252
name: _AA081045_1_m
boundary condition: true
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110045#_750d5bfd_c990_4f71_b34d_5281ecd5add3
is encoded by: hsa:85365
boundary condition: true
initial amount: NaN
has only substance units: false
is: SBO:0000252
type: Species
constant: false
initial concentration: NaN
name: ALG2

metaR PTPAT
reversible: true
notes: GENE_ASSOCIATION: (80347.1) SUBSYSTEM: CoA synthesis EC Number: Confidence Level: 4 AUTHORS: NOTES:
product: MODEL1310110045#
reactant: MODEL1310110045#
type: Reaction
is described by: ECO:0000269
modifier: MODEL1310110045#
is version of: http://identifiers.org/ec-code/2.7.7.3
name: Phosphopantetheine adenylyltransferase (EC 2.7.7.3)
fast: false
is: SBO:0000176
kinetic law: MODEL1310110045#

http://identifiers.org/biomodels.db/MODEL1310110045#_48786c4a_1c79_4c77_a650_317f98f5c83d
boundary condition: true
is: E9KL44
is encoded by: hsa:3030
type: Species
initial concentration: NaN
name: HADHA
constant: false
has only substance units: false
is: SBO:0000252
initial amount: NaN

metaR RE0452M
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Pyrimidine synthesis EC Number: 2.7.4.9 Confidence Level: 0 AUTHORS: PMID:8024690 NOTES:
reactant: MODEL1310110045#
fast: false
name: RE0452
is described by: ECO:0000000
product: MODEL1310110045#
kinetic law: MODEL1310110045#
type: Reaction
reversible: true

metaM lys L e
initial amount: NaN
is: HMDB00182
initial concentration: 1.0
is: SBO:0000247
has only substance units: false
constant: false
notes: FORMULA: C6H15N2O2 CHARGE: 1 INCHI: InChI=1S/C6H14N2O2/c7-4-2-1-3-5(8)6(9)10/h5H,1-4,7-8H2,(H,9,10)/p+1/t5-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00053 EHMN_ABBREVIATION: C00047
name: L-lysinium(1+)
is: CHEBI:32551
boundary condition: false
type: Species

metaM dcacoa x
is: HMDB06404
type: Species
notes: FORMULA: C31H50N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC01413 EHMN_ABBREVIATION: C05274
has only substance units: false
initial concentration: 1.0
is: SBO:0000247
is: CHEBI:61430
initial amount: NaN
name: Decanoyl-CoA (n-C10:0CoA)
constant: false
is: C05274
boundary condition: false

metaR r1696
kinetic law: MODEL1310110045#
is described by: ECO:0000000
name: Y+LAT2 Utilized transport
modifier: MODEL1310110045#
type: Reaction
is: SBO:0000185
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reactant: MODEL1310110045#
reversible: false
product: MODEL1310110045#
fast: false

metaM ser L m
boundary condition: false
initial concentration: 1.0
initial amount: NaN
has only substance units: false
is: SBO:0000247
notes: FORMULA: C3H7NO3 CHARGE: 0 INCHI: InChI=1S/C3H7NO3/c4-2(1-5)3(6)7/h2,5H,1,4H2,(H,6,7)/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00068
is: CHEBI:17115
is: HMDB00187
constant: false
name: L-serine
type: Species

metaR LGTHL
reactant: MODEL1310110045#
notes: GENE_ASSOCIATION: (2739.1) SUBSYSTEM: Pyruvate metabolism EC Number: 4.4.1.5 Confidence Level: 4 AUTHORS: PMID:7684374,PMID:8449929 NOTES:IF
modifier: MODEL1310110045#
type: Reaction
is version of: http://identifiers.org/ec-code/4.4.1.5
fast: false
name: lactoylglutathione lyase
is: SBO:0000176
reversible: false
kinetic law: MODEL1310110045#
is described by: ECO:0000269
product: MODEL1310110045#

metaR EX leuktrC4 LPAREN e RPAREN
kinetic law: MODEL1310110045#
reactant: MODEL1310110045#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Leukotriene C4 exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110045#_b0a82bd2_344a_46f8_90ea_e8ef6e47afbf
initial concentration: NaN
constant: false
name: GALE
boundary condition: true
has only substance units: false
is: Q14376
initial amount: NaN
is encoded by: hsa:2582
type: Species
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110045#_68c25759_b094_4b23_800c_bcbfe8bb239a
is encoded by: hsa:23530
boundary condition: true
initial concentration: NaN
constant: false
type: Species
has only substance units: false
is: SBO:0000252
initial amount: NaN
name: NNT

metaR RE2658R
is described by: ECO:0000000
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Vitamin A metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:9647871 NOTES:
is: SBO:0000176
name: RE2658
kinetic law: MODEL1310110045#
product: MODEL1310110045#
type: Reaction
reversible: true
reactant: MODEL1310110045#

metaR RE2998M
product: MODEL1310110045#
kinetic law: MODEL1310110045#
fast: false
modifier: MODEL1310110045#
reactant: MODEL1310110045#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (51.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.3.6 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:7775433 NOTES:
type: Reaction
name: RE2998
is: SBO:0000176
reversible: false
is version of: http://identifiers.org/ec-code/1.3.3.6

metaR PI45P5P
modifier: MODEL1310110045#
fast: false
is described by: ECO:0000000
product: MODEL1310110045#
is version of: http://identifiers.org/ec-code/3.1.3.36
notes: GENE_ASSOCIATION: (8867.1) or (56623.1) or (4952.1) or (8871.1) or (8867.2) or (4952.2) or (3633.1) SUBSYSTEM: Inositol phosphate metabolism EC Number: 3.1.3.36 Confidence Level: 4 AUTHORS: PMID:10764818,PMID:12915445,PMID:7721860,PMID:7761412 NOTES:NCD
reactant: MODEL1310110045#
type: Reaction
reversible: false
is: SBO:0000176
kinetic law: MODEL1310110045#
name: phosphatidylinositol-4,5-bisphosphate 5-phosphatase

metaM lys L c
has only substance units: false
initial amount: NaN
initial concentration: 1.0
is: HMDB00182
notes: FORMULA: C6H15N2O2 CHARGE: 1 INCHI: InChI=1S/C6H14N2O2/c7-4-2-1-3-5(8)6(9)10/h5H,1-4,7-8H2,(H,9,10)/p+1/t5-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00053 EHMN_ABBREVIATION: C00047
name: L-lysinium(1+)
is: SBO:0000247
constant: false
boundary condition: false
is: CHEBI:32551
type: Species

http://identifiers.org/biomodels.db/MODEL1310110045#_e44f0afb_9165_4413_a32c_b2f375fccf0c
is encoded by: hsa:766
initial concentration: NaN
constant: false
is: Q86YU0
boundary condition: true
has only substance units: false
initial amount: NaN
name: CA7
is: SBO:0000252
type: Species

http://identifiers.org/biomodels.db/MODEL1310110045#_804ecfe4_941c_4f05_b8b0_c12dbafa173d
boundary condition: true
type: Species
is encoded by: hsa:211
constant: false
initial concentration: NaN
initial amount: NaN
is: Q5JAM2
name: ALAS1
has only substance units: false
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110045#_a3ab666e_c887_40cd_9513_8a8dc1f1cc22
type: Species
name: EGFL8
constant: false
is encoded by: hsa:80864
is: Q99944
is: SBO:0000252
has only substance units: false
initial amount: NaN
initial concentration: NaN
boundary condition: true

metaM HC02206 e
initial concentration: 1.0
type: Species
is: SBO:0000247
initial amount: NaN
has only substance units: false
name: prostaglandin C1(1-)
constant: false
notes: FORMULA: C20H31O4 CHARGE: -1 INCHI: InChI=1S/C20H32O4/c1-2-3-6-9-17(21)14-12-16-13-15-19(22)18(16)10-7-4-5-8-11-20(23)24/h12-14,17-18,21H,2-11,15H2,1H3,(H,23,24)/p-1/b14-12+/t17-,18+/m0/s1 EHMN_ABBREVIATION: C04686
is: CHEBI:57399
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110045#_5422552e_0f19_4542_9dee_35a53a1790a3
initial amount: NaN
is: Q14642
boundary condition: true
constant: false
is encoded by: hsa:3632
type: Species
has only substance units: false
is: SBO:0000252
initial concentration: NaN
name: INPP5A

metaM fdp c
boundary condition: false
is: HMDB01058
constant: false
notes: FORMULA: C6H10O12P2 CHARGE: -4 INCHI: " HEPATONET_1.0_ABBREVIATION: HC00300 EHMN_ABBREVIATION: C00354
type: Species
initial concentration: 1.0
is: SBO:0000247
is: C00354
is: CHEBI:16905
initial amount: NaN
is: http://identifiers.org/pubchem.compound/3647
name: D-Fructose 1,6-bisphosphate
has only substance units: false

metaR TDPm
reversible: false
is described by: ECO:0000000
product: MODEL1310110045#
name: thiamin pyrophosphatase, mitochondrial
kinetic law: MODEL1310110045#
is: SBO:0000176
reactant: MODEL1310110045#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Thiamine metabolism EC Number: 3.6.1.15 Confidence Level: 2 AUTHORS: PMID:9755848 NOTES:_01-25-05 IT
type: Reaction

metaM ksi deg21 l
boundary condition: false
is: CHEBI:12936
is: SBO:0000247
initial amount: NaN
notes: FORMULA: C132H213N9O114S6 CHARGE: -6
type: Species
is: HMDB00143
constant: false
initial concentration: 1.0
name: keratan sulfate I, degradation product 21
has only substance units: false

metaM m7mpdol L r
notes: FORMULA: C1720H2828N20O570P20 CHARGE: -20
has only substance units: false
initial concentration: 1.0
name: (alpha-D-Mannosyl)7-beta-D-mannosyl-diacetylchitobiosyldiphosphodolichol, human liver homolog
is: CHEBI:37636
type: Species
boundary condition: false
is: SBO:0000247
initial amount: NaN
constant: false

http://identifiers.org/biomodels.db/MODEL1310110045#_a25b8af9_1c0a_4a30_8a25_6dbba7df6132
is encoded by: hsa:1339
type: Species
has only substance units: false
initial amount: NaN
is: Q02221
constant: false
name: COX6A2
boundary condition: true
is: SBO:0000252
initial concentration: NaN

metaR ACGALtly
product: MODEL1310110045#
kinetic law: MODEL1310110045#
is: SBO:0000185
name: N-acetyl-galactosamine lysosomal efflux
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 2 AUTHORS: PMID:2784441,PMID:3753439 NOTES:NCD
fast: false
is described by: ECO:0000000
reversible: false
type: Reaction
reactant: MODEL1310110045#

metaR r1667
product: MODEL1310110045#
type: Reaction
modifier: MODEL1310110045#
is: SBO:0000185
fast: false
reactant: MODEL1310110045#
kinetic law: MODEL1310110045#
reversible: true
is described by: ECO:0000000
name: Y+LAT2 Utilized transport
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110045#_71d0b9fe_1591_456c_b549_5a38ab1e7f24
is: SBO:0000252
type: Species
name: SLC5A11
is encoded by: hsa:115584
boundary condition: true
is: Q8WWX8
constant: false
initial amount: NaN
initial concentration: NaN
has only substance units: false

metaR r2419
fast: false
reactant: MODEL1310110045#
kinetic law: MODEL1310110045#
is: SBO:0000185
reversible: true
is described by: ECO:0000000
name: Mitochondrial Carrier (MC) TCDB:2.A.29.2.7
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:10585886,PMID:14598172,PMID:4424886,PMID:4441366,PMID:5099217,PMID:8329439 NOTES:
type: Reaction
product: MODEL1310110045#

http://identifiers.org/biomodels.db/MODEL1310110045#_402fe925_f8de_47c4_bda0_c4fc4a0d2439
is encoded by: hsa:7915
initial amount: NaN
name: ALDH5A1
boundary condition: true
initial concentration: NaN
constant: false
has only substance units: false
type: Species
is: SBO:0000252
is: Q546H9

http://identifiers.org/biomodels.db/MODEL1310110045#_b7152884_aeec_46aa_92d9_7c5c90612f2c
is: Q9BZX2
has only substance units: false
boundary condition: true
is encoded by: hsa:7371
type: Species
is: SBO:0000252
constant: false
name: UCK2
initial amount: NaN
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110045#_a8ce98ec_93dc_4f90_9588_da81dd5e7058
has only substance units: false
is encoded by: hsa:100287639
type: Species
initial amount: NaN
boundary condition: true
constant: false
name: _100287639_1_c
initial concentration: NaN
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110045#_90bd538b_7cc0_4713_935f_0e084b2ad08a
has only substance units: false
initial amount: NaN
constant: false
is encoded by: hsa:6565
name: SLC15A2
is: SBO:0000252
is: Q16348
initial concentration: NaN
type: Species
boundary condition: true

metaM 3mb2coa m
is: CHEBI:57344
is: HMDB01493
is: SBO:0000247
initial amount: NaN
name: 3-methylbut-2-enoyl-CoA(4-)
constant: false
has only substance units: false
boundary condition: false
notes: FORMULA: C26H38N7O17P3S CHARGE: -4 INCHI: InChI=1S/C26H42N7O17P3S/c1-14(2)9-17(35)54-8-7-28-16(34)5-6-29-24(38)21(37)26(3,4)11-47-53(44,45)50-52(42,43)46-10-15-20(49-51(39,40)41)19(36)25(48-15)33-13-32-18-22(27)30-12-31-23(18)33/h9,12-13,15,19-21,25,36-37H,5-8,10-11H2,1-4H3,(H,28,34)(H,29,38)(H,42,43)(H,44,45)(H2,27,30,31)(H2,39,40,41)/p-4/t15-,19-,20-,21+,25-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01047 EHMN_ABBREVIATION: C03069
initial concentration: 1.0
type: Species

metaR PPItr
reversible: true
name: Diphosphate transporter, endoplasmic reticulum
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: NOTES:diffusion NJ
reactant: MODEL1310110045#
is: SBO:0000185
fast: false
kinetic law: MODEL1310110045#
is described by: ECO:0000000
type: Reaction
product: MODEL1310110045#

metaR r1668
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reversible: true
product: MODEL1310110045#
is described by: ECO:0000000
name: Y+LAT2 Utilized transport
is: SBO:0000185
fast: false
type: Reaction
reactant: MODEL1310110045#
kinetic law: MODEL1310110045#
modifier: MODEL1310110045#

http://identifiers.org/biomodels.db/MODEL1310110045#_e51cd8b5_a3aa_4c7e_8aee_7bbf408e85b7
is: SBO:0000252
initial concentration: NaN
boundary condition: true
has only substance units: false
is encoded by: hsa:30
type: Species
constant: false
initial amount: NaN
name: ACAA1
is: Q96CA6

metaR FPGS6m
product: MODEL1310110045#
notes: GENE_ASSOCIATION: (2356.1) SUBSYSTEM: Folate metabolism EC Number: 6.3.2.17 Confidence Level: 4 AUTHORS: PMID:10777604 NOTES:IT
is described by: ECO:0000000
modifier: MODEL1310110045#
reversible: false
type: Reaction
kinetic law: MODEL1310110045#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/6.3.2.17
reactant: MODEL1310110045#
fast: false
name: folylpolyglutamate synthetase (DHF), mitochondrial

metaR S6T18g
notes: GENE_ASSOCIATION: (8534.1) or (9469.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: Confidence Level: 4 AUTHORS: PMID:12403612,PMID:8991509,PMID:9405439,PMID:9714738 NOTES:NCD
fast: false
is version of: http://identifiers.org/ec-code/2.8.2.17
is described by: ECO:0000000
reactant: MODEL1310110045#
name: galactose/N-acetylglucosamine 6-O-sulfotransferase, Golgi apparatus
is version of: http://identifiers.org/ec-code/2.8.2.21
is: SBO:0000176
type: Reaction
reversible: false
modifier: MODEL1310110045#
kinetic law: MODEL1310110045#
product: MODEL1310110045#

metaR PTE4x
name: peroxisomal acyl-CoA thioesterase
type: Reaction
reactant: MODEL1310110045#
fast: false
notes: GENE_ASSOCIATION: (10965.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: PMID:10944470 NOTES:NJ
is described by: ECO:0000269
modifier: MODEL1310110045#
kinetic law: MODEL1310110045#
is: SBO:0000176
product: MODEL1310110045#
reversible: false
is version of: http://identifiers.org/ec-code/3.1.2.2

metaM 3mop m
boundary condition: false
is: CHEBI:28654
notes: FORMULA: C6H9O3 CHARGE: -1 INCHI: InChI=1S/C6H10O3/c1-3-4(2)5(7)6(8)9/h4H,3H2,1-2H3,(H,8,9)/p-1 HEPATONET_1.0_ABBREVIATION: HC01123 EHMN_ABBREVIATION: C00671
has only substance units: false
is: SBO:0000247
initial concentration: 1.0
initial amount: NaN
is: HMDB00491
name: 3-methyl-2-oxopentanoate
type: Species
constant: false

metaM HC02206 c
constant: false
is: CHEBI:57399
type: Species
has only substance units: false
is: SBO:0000247
name: prostaglandin C1(1-)
initial amount: NaN
notes: FORMULA: C20H31O4 CHARGE: -1 INCHI: InChI=1S/C20H32O4/c1-2-3-6-9-17(21)14-12-16-13-15-19(22)18(16)10-7-4-5-8-11-20(23)24/h12-14,17-18,21H,2-11,15H2,1H3,(H,23,24)/p-1/b14-12+/t17-,18+/m0/s1 EHMN_ABBREVIATION: C04686
boundary condition: false
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110045#_09810ed0_668d_45de_a78e_ff8b26e8d2e0
is: B3KXN9
initial amount: NaN
is encoded by: hsa:84890
constant: false
type: Species
is: SBO:0000252
name: ADO
boundary condition: true
initial concentration: NaN
has only substance units: false

metaR CHSTEROLtrc
reactant: MODEL1310110045#
name: transport of cholesterol into the cytosol
type: Reaction
fast: false
is: SBO:0000185
product: MODEL1310110045#
kinetic law: MODEL1310110045#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: PMID: 11229876 NOTES:newly synthesized cholesterol may either be incorporated into membrane or transported out of enterocytes.
reversible: true
is described by: ECO:0000134

http://identifiers.org/biomodels.db/MODEL1310110045#_93532d3b_7734_4dba_9c6f_1affa143604a
has only substance units: false
constant: false
type: Species
initial concentration: NaN
name: SLC4A9
is: E9PDK1
boundary condition: true
is: SBO:0000252
is encoded by: hsa:83697
initial amount: NaN

metaM nicrnt c
is: SBO:0000247
is: C01185
is: CHEBI:57502
initial concentration: 1.0
name: Nicotinate D-ribonucleotide
notes: FORMULA: C11H12NO9P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00703 EHMN_ABBREVIATION: C01185
initial amount: NaN
boundary condition: false
type: Species
is: HMDB01132
has only substance units: false
constant: false

metaR r1669
is: SBO:0000185
reversible: true
name: Y+LAT2 Utilized transport
reactant: MODEL1310110045#
is described by: ECO:0000000
fast: false
product: MODEL1310110045#
kinetic law: MODEL1310110045#
modifier: MODEL1310110045#
type: Reaction
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110045#_bbef1cd8_129d_4407_b2b2_771a53713393
has only substance units: false
is: SBO:0000252
boundary condition: true
type: Species
is: P19971
constant: false
is encoded by: hsa:1890
initial amount: NaN
name: TYMP
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110045#_c7752e6c_4f8b_4e44_b853_7071d625e06b
initial amount: NaN
constant: false
is: SBO:0000252
is: Q63HM1
type: Species
boundary condition: true
is encoded by: hsa:125061
has only substance units: false
initial concentration: NaN
name: AFMID

http://identifiers.org/biomodels.db/MODEL1310110045#_b65209f4_7221_43fb_b7d6_f64d161091d3
has only substance units: false
name: PYCRL
initial amount: NaN
is: Q53H96
boundary condition: true
is encoded by: hsa:65263
constant: false
initial concentration: NaN
is: SBO:0000252
type: Species

metaM sphs1p r
type: Species
initial amount: NaN
is: HMDB00277
initial concentration: 1.0
is: SBO:0000247
notes: FORMULA: C18H37NO5P CHARGE: -1 INCHI: InChI=1S/C18H38NO5P/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-18(20)17(19)16-24-25(21,22)23/h14-15,17-18,20H,2-13,16,19H2,1H3,(H2,21,22,23)/p-1/b15-14+/t17-,18+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01702 EHMN_ABBREVIATION: C06124
has only substance units: false
name: sphingosine 1-phosphate(1-)
is: CHEBI:60119
boundary condition: false
constant: false

metaM CE5132 c
name: 1-phosphatidyl-1D-myo-inositol 3,5-bisphosphate(5-)
is: SBO:0000247
has only substance units: false
is: CHEBI:57923
constant: false
initial concentration: 1.0
initial amount: NaN
type: Species
boundary condition: false
notes: FORMULA: C11H14O19P3R2 CHARGE: -5 EHMN_ABBREVIATION: CE5132

metaR NCKt
reversible: true
notes: GENE_ASSOCIATION: (123041.2) or (57419.1) or (9187.1) or (123041.3) or (25769.1) or (123041.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10484410,PMID:10662833,PMID:11294880,PMID:12379639,PMID:14770312,PMID:9478004 NOTES:NCD
type: Reaction
modifier: MODEL1310110045#
is: SBO:0000185
reactant: MODEL1310110045#
product: MODEL1310110045#
kinetic law: MODEL1310110045#
is described by: ECO:0000269
fast: false
name: Na+/Ca2+-K+ exchange

metaR SUCOAS1m
is described by: ECO:0000000
name: Succinate--CoA ligase (GDP-forming)
reactant: MODEL1310110045#
type: Reaction
is version of: http://identifiers.org/ec-code/6.2.1.4
product: MODEL1310110045#
notes: GENE_ASSOCIATION: (8802.1 and 8801.1) SUBSYSTEM: Citric acid cycle EC Number: 6.2.1.4 Confidence Level: 0 AUTHORS: PMID:9765291 NOTES:IF
reversible: true
kinetic law: MODEL1310110045#
fast: false
modifier: MODEL1310110045#
is: SBO:0000176

metaR LGNCt
name: fatty acid transport via diffusion
reactant: MODEL1310110045#
product: MODEL1310110045#
fast: false
reversible: true
kinetic law: MODEL1310110045#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11788354,PMID:12864740 NOTES:NJ
is: SBO:0000185
is described by: ECO:0000000
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110045#_ef297beb_e97f_4667_9fa6_7a25bb623b92
name: _U37519_1_c
initial amount: NaN
type: Species
constant: false
is: SBO:0000252
has only substance units: false
is encoded by: hsa:U37519
boundary condition: true
initial concentration: NaN

metaR EX nrpphr LPAREN e RPAREN
kinetic law: MODEL1310110045#
reactant: MODEL1310110045#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Norepinephrine exchange
type: Reaction

metaM pail45p hs c
initial amount: NaN
type: Species
is: SBO:0000247
initial concentration: 1.0
is: CHEBI:28910
boundary condition: false
notes: FORMULA: C9H14O15P3FULLRCO2FULLR2CO2 CHARGE: -5 EHMN_ABBREVIATION: C04637
has only substance units: false
constant: false
name: phosphatidylinositol 4,5-bisphosphate

http://identifiers.org/biomodels.db/MODEL1310110045#_ee310f05_9479_471a_a671_324afdcd8412
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:6718
initial amount: NaN
is: P51857
name: AKR1D1
type: Species
boundary condition: true
constant: false
has only substance units: false

metaM 4mlacac c
has only substance units: false
is: SBO:0000247
notes: FORMULA: C8H6O6 CHARGE: -2 INCHI: InChI=1S/C8H8O6/c9-5(1-2-7(11)12)3-6(10)4-8(13)14/h1-2H,3-4H2,(H,11,12)(H,13,14)/p-2/b2-1- HEPATONET_1.0_ABBREVIATION: HC00635 EHMN_ABBREVIATION: C01036
is: HMDB02052
boundary condition: false
constant: false
name: 4-maleylacetoacetate
type: Species
is: CHEBI:17105
initial amount: NaN
initial concentration: 1.0

metaR ACOAD8m
kinetic law: MODEL1310110045#
is: SBO:0000176
notes: GENE_ASSOCIATION: (3712.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 1.3.99.10 Confidence Level: 4 AUTHORS: PMID:9214289 NOTES:MM
product: MODEL1310110045#
fast: false
reversible: false
reactant: MODEL1310110045#
is described by: ECO:0000269
name: acyl-CoA dehydrogenase (isovaleryl-CoA), mitochondrial
is version of: http://identifiers.org/ec-code/1.3.99.10
modifier: MODEL1310110045#
type: Reaction

metaM CE2421 m
has only substance units: false
initial concentration: 1.0
notes: FORMULA: C39H62N7O18P3S CHARGE: -4 INCHI: InChI=1/C39H66N7O18P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-27(47)22-30(49)68-21-20-41-29(48)18-19-42-37(52)34(51)39(2,3)24-61-67(58,59)64-66(56,57)60-23-28-33(63-65(53,54)55)32(50)38(62-28)46-26-45-31-35(40)43-25-44-36(31)46/h8-9,11-12,25-28,32-34,38,47,50-51H,4-7,10,13-24H2,1-3H3,(H,41,48)(H,42,52)(H,56,57)(H,58,59)(H2,40,43,44)(H2,53,54,55)/p-4/b9-8-,12-11-/t27-,28-,32+,33+,34u,38-/m0/s1 EHMN_ABBREVIATION: CE2421
is: CHEBI:30623
boundary condition: false
name: (3S)-3-hydroxylinoleoyl-CoA
initial amount: NaN
is: SBO:0000247
constant: false
is: HMDB02329
type: Species

metaR r2416
name: Mitochondrial Carrier (MC) TCDB:2.A.29.19.1
is: SBO:0000185
product: MODEL1310110045#
reversible: false
is described by: ECO:0000000
reactant: MODEL1310110045#
type: Reaction
kinetic law: MODEL1310110045#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:8132483 NOTES:
fast: false

metaM xol7aone c
notes: FORMULA: C27H44O2 CHARGE: 0 INCHI: InChI=1S/C27H44O2/c1-17(2)7-6-8-18(3)21-9-10-22-25-23(12-14-27(21,22)5)26(4)13-11-20(28)15-19(26)16-24(25)29/h15,17-18,21-25,29H,6-14,16H2,1-5H3/t18-,21-,22+,23+,24-,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01464 EHMN_ABBREVIATION: C05455
type: Species
constant: false
is: SBO:0000247
initial amount: NaN
is: CHEBI:17899
name: 7alpha-hydroxycholest-4-en-3-one
initial concentration: 1.0
is: HMDB01993
boundary condition: false
has only substance units: false

metaR NADtpu
fast: false
name: NAD transporter, peroxisome
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 0 AUTHORS: NOTES:diffusion - but unidirectional uptake into peroxisome (to avoid loops w/ NAD/NADP) NJ
reversible: false
type: Reaction
kinetic law: MODEL1310110045#
product: MODEL1310110045#
is: SBO:0000185
is described by: ECO:0000000
reactant: MODEL1310110045#

metaR EX retfa LPAREN e RPAREN
kinetic law: MODEL1310110045#
reactant: MODEL1310110045#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: fatty acid retinol exchange
type: Reaction

metaM prostgd2 r
is: CHEBI:57406
initial amount: NaN
name: prostaglandin D2(1-)
notes: FORMULA: C20H31O5 CHARGE: -1 INCHI: InChI=1S/C20H32O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h4,7,12-13,15-18,21-22H,2-3,5-6,8-11,14H2,1H3,(H,24,25)/p-1/b7-4-,13-12+/t15-,16+,17+,18-/m0/s1 EHMN_ABBREVIATION: C00696
constant: false
is: HMDB01403
is: SBO:0000247
initial concentration: 1.0
has only substance units: false
boundary condition: false
type: Species

metaR EX arachd LPAREN e RPAREN
kinetic law: MODEL1310110045#
reactant: MODEL1310110045#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: nC20:4 exchange
type: Reaction

metaR DURIK1
type: Reaction
name: deoxyuridine kinase (ATP:Deoxyuridine)
is version of: http://identifiers.org/ec-code/2.7.1.21
notes: GENE_ASSOCIATION: (7083.1) or (7084.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.1.21 Confidence Level: 2 AUTHORS: PMID:12535661,PMID:9342341 NOTES:
reversible: false
kinetic law: MODEL1310110045#
is: SBO:0000176
modifier: MODEL1310110045#
reactant: MODEL1310110045#
is described by: ECO:0000254
product: MODEL1310110045#
fast: false

metaM HC00695 m
is: SBO:0000247
initial concentration: 1.0
notes: FORMULA: C12H20NO4S2 CHARGE: -1 INCHI: InChI=1S/C12H21NO4S2/c13-10(14)4-2-1-3-9(18)7-8-19-12(17)6-5-11(15)16/h9,18H,1-8H2,(H2,13,14)(H,15,16) EHMN_ABBREVIATION: C01169
constant: false
boundary condition: false
name: S-Succinyldihydrolipoamide
initial amount: NaN
has only substance units: false
is: CHEBI:17432
type: Species

metaR PPItm
product: MODEL1310110045#
is described by: ECO:0000134
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 1 AUTHORS: added during gap-filling. NOTES:added during gap-filling.
kinetic law: MODEL1310110045#
reversible: true
is: SBO:0000185
name: diphopshate transporter, mitochondrial
reactant: MODEL1310110045#
type: Reaction

metaR r1664
fast: false
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
type: Reaction
modifier: MODEL1310110045#
is described by: ECO:0000000
product: MODEL1310110045#
name: Y+LAT2 Utilized transport
kinetic law: MODEL1310110045#
reversible: true
reactant: MODEL1310110045#
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110045#_c249e502_69dc_448f_94ab_877918da93ac
boundary condition: true
has only substance units: false
is encoded by: hsa:54995
constant: false
name: OXSM
type: Species
initial concentration: NaN
is: SBO:0000252
is: Q9NWU1
initial amount: NaN

metaR NADH2 u10m
type: Reaction
is: SBO:0000185
is described by: ECO:0000134
reactant: MODEL1310110045#
fast: false
notes: GENE_ASSOCIATION: (4715.1) and (4720.1) and (4719.1) and (55967.1) and (4700.1) and (4709.1) and (4710.1) and (4726.1) and (4696.1) and (4718.1) and (4694.1) and (374291.1) and (4728.1) and (4717.1) and (4731.1) and (4705.1) and (4725.1) and (4716.1) and (4537.1) and (4722.1) and (7991.1) and (4541.1) and (4539.1) and (4712.1) and (4707.1) and (4701.1) and (4723.1) and (4698.1) and (4538.1) and (4697.1) and (51079.1) and (4714.1) and (4704.1) and (4711.1) and (126328.1) and (4724.1) and (4713.1) and (4536.1) and (4695.1) and (4702.1) and (4708.1) and (4706.1) and (4535.1) and (4540.1) and (4729.1) or (4715.1) and (4720.1) and (4719.1) and (4700.1) and (55967.1) and (4709.1) and (4710.1) and (4726.1) and (4718.1) and (4696.1) and (4694.1) and (374291.1) and (4728.1) and (4712.2) and (4717.1) and (4705.1) and (4725.1) and (4716.1) and (4537.1) and (7991.1) and (4722.1) and (4541.1) and (4539.1) and (4707.1) and (4701.1) and (4723.1) and (4698.1) and (4538.1) and (4697.1) and (51079.1) and (4714.1) and (4704.1) and (126328.1) and (4711.1) and (4724.1) and (4713.1) and (4536.1) and (4695.1) and (4702.1) and (4708.1) and (4535.1) and (4731.2) and (4706.1) and (4729.1) and (4540.1) or (4715.1) and (4720.1) and (4719.1) and (4700.1) and (55967.1) and (4709.1) and (4710.1) and (4726.1) and (4718.1) and (4696.1) and (4694.1) and (374291.1) and (4728.1) and (7991.2) and (4717.1) and (4705.1) and (4725.1) and (4537.1) and (4716.1) and (4722.1) and (4541.1) and (4712.1) and (4539.1) and (4707.1) and (4701.1) and (4723.1) and (4698.1) and (4538.1) and (4697.1) and (51079.1) and (4714.1) and (4704.1) and (4711.1) and (126328.1) and (4724.1) and (4713.1) and (4536.1) and (4695.1) and (4702.1) and (4708.1) and (4535.1) and (4731.2) and (4706.1) and (4540.1) and (4729.1) or (4715.1) and (4720.1) and (4719.1) and (55967.1) and (4700.1) and (4709.1) and (4710.1) and (4726.1) and (4696.1) and (4718.1) and (374291.1) and (4694.1) and (4728.1) and (4712.2) and (4717.1) and (4731.1) and (…
reversible: false
product: MODEL1310110045#
is version of: http://identifiers.org/ec-code/1.6.5.3
name: NADH dehydrogenase, mitochondrial
modifier: MODEL1310110045#
kinetic law: MODEL1310110045#
is version of: http://identifiers.org/ec-code/1.6.99.3

http://identifiers.org/biomodels.db/MODEL1310110045#_663fd527_6a34_48d5_a3df_8c8213783998
constant: false
has only substance units: false
name: ALDH3B1
is encoded by: hsa:221
initial amount: NaN
boundary condition: true
type: Species
is: P43353
is: SBO:0000252
initial concentration: NaN

metaR r1318
reversible: true
fast: false
reactant: MODEL1310110045#
is described by: ECO:0000000
name: Transport reaction
is: SBO:0000185
product: MODEL1310110045#
kinetic law: MODEL1310110045#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:17466261 NOTES:
type: Reaction

metaR EX sph1p LPAREN e RPAREN
kinetic law: MODEL1310110045#
reactant: MODEL1310110045#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Sphinganine 1-phosphate exchange
type: Reaction

metaR C226CRNt
fast: false
reactant: MODEL1310110045#
kinetic law: MODEL1310110045#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: PMID:14598172 NOTES:TDV
is: SBO:0000185
reversible: false
name: C226 transport into the mitochondria
type: Reaction
product: MODEL1310110045#

metaR CSND
reversible: false
is: SBO:0000176
name: Cytosine deaminase
notes: GENE_ASSOCIATION: SUBSYSTEM: Pyrimidine catabolism EC Number: 3.5.4.1 Confidence Level: 2 AUTHORS: NOTES:JLR. Part of a famous suicide gene combination with 5-fluorocytosine
is described by: ECO:0000000
kinetic law: MODEL1310110045#
fast: false
product: MODEL1310110045#
type: Reaction
reactant: MODEL1310110045#

metaR CYSGLUexR
is: SBO:0000185
modifier: MODEL1310110045#
fast: false
kinetic law: MODEL1310110045#
product: MODEL1310110045#
reversible: true
name: L-cysteine/L-glutamine reversible exchanger
notes: GENE_ASSOCIATION: (6520.1) and (56301.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10734121,PMID:10863037,PMID:14770310 NOTES:
type: Reaction
is described by: ECO:0000304
reactant: MODEL1310110045#

http://identifiers.org/biomodels.db/MODEL1310110045#_043c2fd2_ad60_416b_8fbf_e47408bf2884
initial concentration: NaN
type: Species
is: SBO:0000252
constant: false
name: UGP2
initial amount: NaN
has only substance units: false
boundary condition: true
is encoded by: hsa:7360

metaR r1665
type: Reaction
modifier: MODEL1310110045#
fast: false
is: SBO:0000185
reactant: MODEL1310110045#
is described by: ECO:0000000
reversible: true
name: Y+LAT2 Utilized transport
kinetic law: MODEL1310110045#
product: MODEL1310110045#
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:

metaR UDPGLCter
reversible: true
type: Reaction
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: PMID:10369669 NOTES:NCD
fast: false
name: UDP-Glc endoplasmic reticulum transport via CMP antiport
kinetic law: MODEL1310110045#
reactant: MODEL1310110045#
is described by: ECO:0000000
product: MODEL1310110045#

metaR PSt3
kinetic law: MODEL1310110045#
type: Reaction
reactant: MODEL1310110045#
fast: false
name: phosphatidylserine transport
product: MODEL1310110045#
is described by: ECO:0000269
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: 2.7.8.8 Confidence Level: 2 AUTHORS: NOTES:
is: SBO:0000185
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110045#_b178137c_65c1_4b0b_8373_88f3056882a5
name: TKTL2
constant: false
initial concentration: NaN
is: Q9H0I9
has only substance units: false
type: Species
initial amount: NaN
is encoded by: hsa:84076
boundary condition: true
is: SBO:0000252

metaR RE1898C
name: RE1898
fast: false
product: MODEL1310110045#
kinetic law: MODEL1310110045#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Urea cycle EC Number: 2.5.1.46 Confidence Level: 0 AUTHORS: PMID:9188485 NOTES:
reversible: true
is described by: ECO:0000000
is: SBO:0000176
reactant: MODEL1310110045#

metaR RE3520E
reactant: MODEL1310110045#
reversible: true
is version of: http://identifiers.org/ec-code/1.11.1.9
is described by: ECO:0000000
modifier: MODEL1310110045#
is: SBO:0000176
type: Reaction
product: MODEL1310110045#
kinetic law: MODEL1310110045#
name: RE3520
fast: false
notes: GENE_ASSOCIATION: (2880.1) or (257202.1) or (2882.1) or (2878.1) SUBSYSTEM: Arachidonic acid metabolism EC Number: 1.11.1.9 Confidence Level: 0 AUTHORS: PMID:10224163,PMID:2377602,PMID:3942774,PMID:9837935 NOTES:

metaM malthx e
initial amount: NaN
boundary condition: false
is: SBO:0000247
is: http://identifiers.org/pubchem.compound/5041
name: Maltohexaose
notes: FORMULA: C36H62O31 CHARGE: 0 INCHI: InChI=1/C36H62O31/c37-1-7-13(43)14(44)21(51)32(58-7)64-27-9(3-39)60-34(23(53)16(27)46)66-29-11(5-41)62-36(25(55)18(29)48)67-30-12(6-42)61-35(24(54)19(30)49)65-28-10(4-40)59-33(22(52)17(28)47)63-26-8(2-38)57-31(56)20(50)15(26)45/h7-56H,1-6H2/t7-,8-,9-,10-,11-,12-,13-,14+,15-,16-,17-,18-,19-,20-,21-,22-,23-,24-,25-,26-,27-,28-,29-,30-,31?,32-,33-,34-,35-,36-/m1/s1 EHMN_ABBREVIATION: C01936
constant: false
is: C01936
type: Species
has only substance units: false
initial concentration: 1.0

metaR EX HC01609 LPAREN e RPAREN
kinetic law: MODEL1310110045#
reactant: MODEL1310110045#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of UroporphyrinogenI
type: Reaction

metaR EX hxan LPAREN e RPAREN
kinetic law: MODEL1310110045#
reactant: MODEL1310110045#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Hypoxanthine exchange
type: Reaction

metaR LTD4DP
product: MODEL1310110045#
reversible: true
type: Reaction
kinetic law: MODEL1310110045#
notes: GENE_ASSOCIATION: SUBSYSTEM: Eicosanoid metabolism EC Number: 2.3.2.2 Confidence Level: 4 AUTHORS: PMID:11160764,PMID:3001504 NOTES:Converts leukotriene D4 (LTD4) to leukotriene E4 (LTE4). unknown compartmentalization, cytosolic by default NJ
reactant: MODEL1310110045#
is: SBO:0000176
is described by: ECO:0000000
name: Leukotriene D4 dipeptidase
fast: false

metaR LPS3e
fast: false
is version of: http://identifiers.org/ec-code/3.1.1.3
kinetic law: MODEL1310110045#
product: MODEL1310110045#
type: Reaction
name: lipase, extracellular
notes: GENE_ASSOCIATION: (3990.1) SUBSYSTEM: Fatty acid oxidation EC Number: 3.1.1.23 Confidence Level: 2 AUTHORS: PMID:14630921 NOTES:NJ
modifier: MODEL1310110045#
reversible: false
reactant: MODEL1310110045#
is described by: ECO:0000000
is: SBO:0000176

metaR r1666
product: MODEL1310110045#
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is described by: ECO:0000000
reversible: true
name: Y+LAT2 Utilized transport
fast: false
is: SBO:0000185
type: Reaction
reactant: MODEL1310110045#
kinetic law: MODEL1310110045#
modifier: MODEL1310110045#

metaM crn x
type: Species
name: L-Carnitine
boundary condition: false
is: CHEBI:16347
notes: FORMULA: C7H15NO3 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00270 EHMN_ABBREVIATION: C00318
initial amount: NaN
is: HMDB00062
is: C00318
initial concentration: 1.0
has only substance units: false
is: SBO:0000247
constant: false

http://identifiers.org/biomodels.db/MODEL1310110045#_da9e6df0_bee9_4c35_ad0e_7d76eee21969
is: GO:0005764
is: SBO:0000290
constant: false
size: 1.0
spatial dimensions: 3.0
name: lysosome
type: Compartment

metaR CHAT
reactant: MODEL1310110045#
kinetic law: MODEL1310110045#
modifier: MODEL1310110045#
notes: GENE_ASSOCIATION: (1103.4) or (1103.2) or (1103.3) or (1103.1) SUBSYSTEM: Glycerophospholipid metabolism EC Number: 2.3.1.6 Confidence Level: 4 AUTHORS: PMID:10861222 NOTES:rev by uniprot NJ
product: MODEL1310110045#
fast: false
is described by: ECO:0000269
name: Choline O-acetyltransferase
type: Reaction
is version of: http://identifiers.org/ec-code/2.3.1.6
is: SBO:0000176
reversible: true

metaR DOLPH Ler
is described by: ECO:0000000
kinetic law: MODEL1310110045#
product: MODEL1310110045#
notes: GENE_ASSOCIATION: SUBSYSTEM: N-glycan synthesis EC Number: 3.1.3.51 Confidence Level: 0 AUTHORS: PMID:11425794 NOTES:
is: SBO:0000176
reversible: false
reactant: MODEL1310110045#
fast: false
name: Dolichol-phosphate phosphohydrolase, human (liver)
type: Reaction

metaR EX dgmp LPAREN e RPAREN
kinetic law: MODEL1310110045#
reactant: MODEL1310110045#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of dGMP(2-)
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110045#_8b85ffc0_3cec_46c3_9487_82e63152f36c
is encoded by: hsa:R14373
name: _R14373_1_x
constant: false
type: Species
has only substance units: false
is: SBO:0000252
initial concentration: NaN
initial amount: NaN
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110045#_a0c52718_a419_4b23_bf9c_c901dfe46289
is: SBO:0000252
boundary condition: true
type: Species
has only substance units: false
initial concentration: NaN
initial amount: NaN
name: PIP4K2B
is encoded by: hsa:8396
is: P78356
constant: false

metaM met L e
constant: false
boundary condition: false
name: L-methionine
is: HMDB00696
is: SBO:0000247
type: Species
is: CHEBI:16643
initial concentration: 1.0
notes: FORMULA: C5H11NO2S CHARGE: 0 INCHI: InChI=1S/C5H11NO2S/c1-9-3-2-4(6)5(7)8/h4H,2-3,6H2,1H3,(H,7,8)/t4-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00075
has only substance units: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110045#_e1239cab_ca16_4ee8_a6af_9084260d1b63
has only substance units: false
is: O00750
initial concentration: NaN
boundary condition: true
constant: false
is encoded by: hsa:5287
name: PIK3C2B
initial amount: NaN
is: SBO:0000252
type: Species

metaR r1554
reactant: MODEL1310110045#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
type: Reaction
is: SBO:0000185
is described by: ECO:0000000
product: MODEL1310110045#
kinetic law: MODEL1310110045#
reversible: true

metaR r0191
fast: false
type: Reaction
modifier: MODEL1310110045#
notes: GENE_ASSOCIATION: (7915.1) or (9856.1) SUBSYSTEM: Fructose and mannose metabolism EC Number: 2.7.1.11 Confidence Level: 0 AUTHORS: PMID:11945275,PMID:4276999 NOTES:
product: MODEL1310110045#
reactant: MODEL1310110045#
reversible: false
kinetic law: MODEL1310110045#
is: SBO:0000176
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/1.2.1.24
name: UTP:D-fructose-6-phosphate 1-phosphotransferase EC:2.7.1.11

http://identifiers.org/biomodels.db/MODEL1310110045#_98c6d58c_ee3c_4e9c_9dde_c5670adc7a5d
initial amount: NaN
boundary condition: true
type: Species
constant: false
has only substance units: false
initial concentration: NaN
name: LTA4H
is encoded by: hsa:4048
is: SBO:0000252
is: P09960

metaM 1pyr5c m
name: 1-Pyrroline-5-carboxylate
is: CHEBI:15893
constant: false
has only substance units: false
notes: FORMULA: C5H6NO2 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC01199 EHMN_ABBREVIATION: C03912
is: HMDB01301
boundary condition: false
is: SBO:0000247
type: Species
initial amount: NaN
is: C03912
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110045#_514b871c_a5c4_4fcf_99ea_01ee372d7a8e
name: NDUFA12
boundary condition: true
type: Species
is: F8VQS7
has only substance units: false
initial concentration: NaN
is: SBO:0000252
initial amount: NaN
constant: false
is encoded by: hsa:55967

http://identifiers.org/biomodels.db/MODEL1310110045#_de8fef62_37e5_4e0b_8ed9_5442a1bd9fee
name: MTMR3
is encoded by: hsa:8897
constant: false
has only substance units: false
initial amount: NaN
type: Species
is: SBO:0000252
initial concentration: NaN
boundary condition: true

metaM rbt e
type: Species
is: HMDB00508
boundary condition: false
initial concentration: 1.0
is: SBO:0000247
is: CHEBI:15963
initial amount: NaN
notes: FORMULA: C5H12O5 CHARGE: 0 INCHI: InChI=1S/C5H12O5/c6-1-3(8)5(10)4(9)2-7/h3-10H,1-2H2/t3-,4+,5- HEPATONET_1.0_ABBREVIATION: HC00380
constant: false
name: D-ribitol
has only substance units: false

metaR S6T2g
notes: GENE_ASSOCIATION: (23563.2) or (9435.1) or (23563.1) or (10164.1) or (4166.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: Confidence Level: 4 AUTHORS: PMID:10330415,PMID:10491328,PMID:10913333,PMID:11278593,PMID:12403612,PMID:12855678,PMID:9722682 NOTES:NCD
reversible: false
is described by: ECO:0000000
type: Reaction
is: SBO:0000176
product: MODEL1310110045#
kinetic law: MODEL1310110045#
modifier: MODEL1310110045#
name: galactose/N-acetylglucosamine 6-O-sulfotransferase, Golgi apparatus
fast: false
reactant: MODEL1310110045#

metaR GLNtN1
modifier: MODEL1310110045#
fast: false
is described by: ECO:0000269
type: Reaction
is: SBO:0000185
reactant: MODEL1310110045#
reversible: true
kinetic law: MODEL1310110045#
product: MODEL1310110045#
name: Glutamine transport (Na, H coupled)
notes: GENE_ASSOCIATION: (92745.1) or (10991.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10823827,PMID:12845534 NOTES:SAB based om PMID 10823827

metaR CYTK14n
type: Reaction
reactant: MODEL1310110045#
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
name: cytidylate kinase (dCMP,CTP),nuclear
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.7.4.14
is described by: ECO:0000269
kinetic law: MODEL1310110045#
reversible: true
product: MODEL1310110045#
modifier: MODEL1310110045#
fast: false

http://identifiers.org/biomodels.db/MODEL1310110045#_ca441296_0f25_4739_8fe0_9b85d63c9abf
boundary condition: true
is encoded by: hsa:79646
initial concentration: NaN
constant: false
has only substance units: false
initial amount: NaN
name: PANK3
is: Q9H999
is: SBO:0000252
type: Species

metaR RE0915E
is: SBO:0000176
kinetic law: MODEL1310110045#
is described by: ECO:0000000
type: Reaction
is version of: http://identifiers.org/ec-code/3.2.1.17
is version of: http://identifiers.org/ec-code/3.2.1.1
reversible: true
notes: GENE_ASSOCIATION: (280.1) or (84569.1) or (276.1) or (277.1) or (278.1) or (279.1) or (276.1) or (277.1) or (278.1) or (279.1) SUBSYSTEM: Starch and sucrose metabolism EC Number: 3.2.1.1 Confidence Level: 0 AUTHORS: PMID:385176,PMID:8528071,PMID:890964 NOTES:
reactant: MODEL1310110045#
fast: false
modifier: MODEL1310110045#
product: MODEL1310110045#
name: RE0915

metaM met L c
initial amount: NaN
has only substance units: false
boundary condition: false
is: CHEBI:16643
initial concentration: 1.0
constant: false
type: Species
is: HMDB00696
notes: FORMULA: C5H11NO2S CHARGE: 0 INCHI: InChI=1S/C5H11NO2S/c1-9-3-2-4(6)5(7)8/h4H,2-3,6H2,1H3,(H,7,8)/t4-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00075
is: SBO:0000247
name: L-methionine

metaR r1556
type: Reaction
product: MODEL1310110045#
reversible: true
is: SBO:0000185
is described by: ECO:0000000
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reactant: MODEL1310110045#
kinetic law: MODEL1310110045#

metaR NRPPHRt4 2 r
product: MODEL1310110045#
name: Norepinephrine reversible transport in via sodium symport (1:2)
reactant: MODEL1310110045#
fast: false
modifier: MODEL1310110045#
reversible: true
kinetic law: MODEL1310110045#
is: SBO:0000185
type: Reaction
notes: GENE_ASSOCIATION: (6530.1) or (6531.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12719981 NOTES:SAB
is described by: ECO:0000269

metaM for e
constant: false
type: Species
is: SBO:0000247
boundary condition: false
notes: FORMULA: CH1O2 CHARGE: -1 INCHI: InChI=1S/CH2O2/c2-1-3/h1H,(H,2,3)/p-1 HEPATONET_1.0_ABBREVIATION: HC00061 EHMN_ABBREVIATION: C00058
initial concentration: 1.0
has only substance units: false
is: CHEBI:15740
initial amount: NaN
is: HMDB00142
name: formate

metaM srtn c
initial amount: NaN
name: serotonin(1+)
initial concentration: 1.0
boundary condition: false
is: CHEBI:350546
type: Species
is: SBO:0000247
constant: false
notes: FORMULA: C10H13N2O CHARGE: 1 INCHI: InChI=1S/C10H12N2O/c11-4-3-7-6-12-10-2-1-8(13)5-9(7)10/h1-2,5-6,12-13H,3-4,11H2/p+1 HEPATONET_1.0_ABBREVIATION: HC00533 EHMN_ABBREVIATION: C00780
is: HMDB00259
has only substance units: false

metaR DNDPt25m
fast: false
reactant: MODEL1310110045#
modifier: MODEL1310110045#
type: Reaction
kinetic law: MODEL1310110045#
reversible: false
notes: GENE_ASSOCIATION: (60386.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:11226231 NOTES:IT
name: dTDP transport via dCDP antiport
is described by: ECO:0000269
is: SBO:0000185
product: MODEL1310110045#

metaR r0193
fast: false
type: Reaction
reactant: MODEL1310110045#
notes: GENE_ASSOCIATION: SUBSYSTEM: Cysteine Metabolism EC Number: 4.4.1.1 Confidence Level: 0 AUTHORS: PMID:10212249,PMID:629532 NOTES:
name: L-Cysteine L-homocysteine-lyase (deaminating) Cysteine metabolism EC:4.4.1.1
product: MODEL1310110045#
reversible: true
is: SBO:0000176
is described by: ECO:0000000
kinetic law: MODEL1310110045#

metaR EX CE5788 LPAREN e RPAREN
kinetic law: MODEL1310110045#
reactant: MODEL1310110045#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: kinetensin 1-7 exchange
type: Reaction

metaR PPItx
product: MODEL1310110045#
is: SBO:0000185
fast: false
name: Diphosphate transporter, peroxisome
reactant: MODEL1310110045#
kinetic law: MODEL1310110045#
reversible: true
is described by: ECO:0000000
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 1 AUTHORS: NOTES:diffusion NJ

metaR RTOTALFATPc
kinetic law: MODEL1310110045#
product: MODEL1310110045#
reactant: MODEL1310110045#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: uptake of Rtotal by enterocytes
type: Reaction

metaR r1557
is: SBO:0000185
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
fast: false
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reactant: MODEL1310110045#
reversible: true
is described by: ECO:0000000
kinetic law: MODEL1310110045#
product: MODEL1310110045#

metaM hmgcoa c
has only substance units: false
is: SBO:0000247
initial amount: NaN
notes: FORMULA: C27H39N7O20P3S CHARGE: -5 INCHI: InChI=1S/C27H44N7O20P3S/c1-26(2,21(40)24(41)30-5-4-15(35)29-6-7-58-17(38)9-27(3,42)8-16(36)37)11-51-57(48,49)54-56(46,47)50-10-14-20(53-55(43,44)45)19(39)25(52-14)34-13-33-18-22(28)31-12-32-23(18)34/h12-14,19-21,25,39-40,42H,4-11H2,1-3H3,(H,29,35)(H,30,41)(H,36,37)(H,46,47)(H,48,49)(H2,28,31,32)(H2,43,44,45)/t14-,19-,20-,21+,25-,27+/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00302 EHMN_ABBREVIATION: C00356
is: CHEBI:15467
is: HMDB01375
name: Hydroxymethylglutaryl-CoA
constant: false
boundary condition: false
type: Species
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110045#_d30e4c06_328a_496f_a1fd_5be7a3472b4f
type: Species
name: COX7B
is: SBO:0000252
is: P24311
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:1349
boundary condition: true
constant: false
has only substance units: false

metaM rbt c
constant: false
type: Species
boundary condition: false
initial concentration: 1.0
is: HMDB00508
notes: FORMULA: C5H12O5 CHARGE: 0 INCHI: InChI=1S/C5H12O5/c6-1-3(8)5(10)4(9)2-7/h3-10H,1-2H2/t3-,4+,5- HEPATONET_1.0_ABBREVIATION: HC00380
is: CHEBI:15963
name: D-ribitol
has only substance units: false
is: SBO:0000247
initial amount: NaN

metaR MMMm
name: methylmalonyl-CoA mutase
type: Reaction
fast: false
is: SBO:0000176
reactant: MODEL1310110045#
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/5.4.99.2
reversible: true
notes: GENE_ASSOCIATION: (4594.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 5.4.99.2 Confidence Level: 4 AUTHORS: PMID:8990001 NOTES:TDV
modifier: MODEL1310110045#
product: MODEL1310110045#
kinetic law: MODEL1310110045#

metaM pro D c
has only substance units: false
name: D-proline
type: Species
constant: false
initial amount: NaN
notes: FORMULA: C5H9NO2 CHARGE: 0 INCHI: InChI=1S/C5H9NO2/c7-5(8)4-2-1-3-6-4/h4,6H,1-3H2,(H,7,8)/t4-/m1/s1
boundary condition: false
initial concentration: 1.0
is: SBO:0000247
is: CHEBI:16313
is: HMDB03411

metaM L2aadp m
name: L-2-aminoadipate(1-)
notes: FORMULA: C6H10NO4 CHARGE: -1 INCHI: InChI=1S/C6H11NO4/c7-4(6(10)11)2-1-3-5(8)9/h4H,1-3,7H2,(H,8,9)(H,10,11)/p-1/t4-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00599 EHMN_ABBREVIATION: C00956
type: Species
initial amount: NaN
initial concentration: 1.0
boundary condition: false
is: CHEBI:58672
has only substance units: false
is: HMDB00510
is: SBO:0000247
constant: false

metaM pram c
constant: false
is: CHEBI:58681
boundary condition: false
name: 5-Phospho-beta-D-ribosylamine
initial concentration: 1.0
type: Species
is: C03090
has only substance units: false
is: SBO:0000247
is: HMDB01128
notes: FORMULA: C5H11NO7P CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC01053 EHMN_ABBREVIATION: C03090
initial amount: NaN

metaR RE2660N
modifier: MODEL1310110045#
is version of: http://identifiers.org/ec-code/4.2.1.96
name: RE2660
kinetic law: MODEL1310110045#
notes: GENE_ASSOCIATION: (5092.1) or (84105.1) SUBSYSTEM: Tetrahydrobiopterin metabolism EC Number: 4.2.1.96 Confidence Level: 0 AUTHORS: PMID:8921004 NOTES:
is described by: ECO:0000000
reactant: MODEL1310110045#
product: MODEL1310110045#
type: Reaction
reversible: true
is: SBO:0000176
fast: false

metaM CE5788 e
constant: false
type: Species
is: CHEBI:27485
is: SBO:0000247
name: kinetensin 1-7
is: HMDB02710
boundary condition: false
has only substance units: false
initial concentration: 1.0
notes: FORMULA: C41H67N15O9 CHARGE: 2 INCHI: InChI=1/C41H65N15O9/c1-4-22(2)32(42)37(62)51-23(3)33(58)52-27(8-5-15-48-40(43)44)34(59)53-28(9-6-16-49-41(45)46)35(60)54-29(19-25-20-47-21-50-25)38(63)56-17-7-10-31(56)36(61)55-30(39(64)65)18-24-11-13-26(57)14-12-24/h11-14,20-23,27-32,57H,4-10,15-19,42H2,1-3H3,(H,47,50)(H,51,62)(H,52,58)(H,53,59)(H,54,60)(H,55,61)(H,64,65)(H4,43,44,48)(H4,45,46,49)/p+2/t22-,23+,27-,28+,29-,30+,31-,32-/m1/s1 EHMN_ABBREVIATION: CE5788
initial amount: NaN

metaR GLYt7 211 r
product: MODEL1310110045#
reversible: true
type: Reaction
modifier: MODEL1310110045#
is described by: ECO:0000269
reactant: MODEL1310110045#
notes: GENE_ASSOCIATION: (6536.1) or (6536.2) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12719981 NOTES:SAB
fast: false
is: SBO:0000185
kinetic law: MODEL1310110045#
name: glycine reversible transport via sodium and chloride symport (2:1:1)

http://identifiers.org/biomodels.db/MODEL1310110045#_4174d37e_bb9f_4997_8b68_8bae65298eed
name: CLYBL
type: Species
is: SBO:0000252
is encoded by: hsa:171425
initial concentration: NaN
initial amount: NaN
has only substance units: false
constant: false
boundary condition: true
is: Q8N0X4

metaM ksii core2 deg6 l
is: CHEBI:12936
constant: false
name: keratan sulfate II (core 2-linked), degradation product 6
type: Species
initial concentration: 1.0
boundary condition: false
has only substance units: false
initial amount: NaN
is: SBO:0000247
notes: FORMULA: C44H72N4O33SX CHARGE: -1
is: HMDB00143

metaM mev R c
type: Species
is: HMDB00227
notes: FORMULA: C6H11O4 CHARGE: -1 INCHI: InChI=1S/C6H12O4/c1-6(10,2-3-7)4-5(8)9/h7,10H,2-4H2,1H3,(H,8,9)/p-1/t6-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00343
initial concentration: 1.0
is: CHEBI:36464
boundary condition: false
name: (R)-mevalonate
constant: false
initial amount: NaN
is: SBO:0000247
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110045#_c23750ab_8017_4b1c_a9d5_111922df26cc
boundary condition: true
initial concentration: NaN
constant: false
initial amount: NaN
is: Q8TDB8
type: Species
is encoded by: hsa:144195
is: SBO:0000252
name: SLC2A14
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110045#_e6984d7d_1ab1_4151_a0c3_eb91cb6d83bd
initial amount: NaN
boundary condition: true
is: Q9Y619
is: SBO:0000252
initial concentration: NaN
name: SLC25A15
has only substance units: false
is encoded by: hsa:10166
type: Species
constant: false

metaR F6Tg
name: glycoprotein 6-alpha-L-fucosyltransferase
is: SBO:0000176
fast: false
kinetic law: MODEL1310110045#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (2530.4) or (2530.1) or (2530.3) or (2530.2) or (2530.5) SUBSYSTEM: N-glycan synthesis EC Number: 2.4.1.68 Confidence Level: 0 AUTHORS: PMID:14514715 NOTES:NCD
type: Reaction
reversible: false
modifier: MODEL1310110045#
is version of: http://identifiers.org/ec-code/2.4.1.68
product: MODEL1310110045#
reactant: MODEL1310110045#

metaM for c
initial concentration: 1.0
boundary condition: false
is: HMDB00142
is: CHEBI:15740
is: SBO:0000247
notes: FORMULA: CH1O2 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00061 EHMN_ABBREVIATION: C00058
has only substance units: false
is: C00058
constant: false
initial amount: NaN
type: Species
name: Formate

metaM arachcrn c
initial amount: NaN
is: HMDB06460
boundary condition: false
is: SBO:0000247
name: arachidyl carnitine
has only substance units: false
notes: FORMULA: C27H53NO4 CHARGE: 0 INCHI: InChI=1/C27H53NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-27(31)32-25(23-26(29)30)24-28(2,3)4/h25H,5-24H2,1-4H3
type: Species
initial concentration: 1.0
constant: false

metaR r1559
reversible: true
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
type: Reaction
reactant: MODEL1310110045#
is described by: ECO:0000000
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
kinetic law: MODEL1310110045#
product: MODEL1310110045#
is: SBO:0000185

metaM sphs1p c
type: Species
constant: false
initial amount: NaN
notes: FORMULA: C18H37NO5P CHARGE: -1 INCHI: InChI=1S/C18H38NO5P/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-18(20)17(19)16-24-25(21,22)23/h14-15,17-18,20H,2-13,16,19H2,1H3,(H2,21,22,23)/p-1/b15-14+/t17-,18+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01702 EHMN_ABBREVIATION: C06124
is: HMDB00277
initial concentration: 1.0
is: CHEBI:60119
boundary condition: false
name: sphingosine 1-phosphate(1-)
is: SBO:0000247
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110045#_57d4a4db_4b23_41db_969c_282d9b83a7fe
is encoded by: hsa:8639
name: AOC3
has only substance units: false
initial amount: NaN
is: SBO:0000252
initial concentration: NaN
boundary condition: true
constant: false
is: Q16853
type: Species

metaM crn r
constant: false
has only substance units: false
is: CHEBI:16347
type: Species
initial amount: NaN
is: SBO:0000247
is: HMDB00062
name: (R)-carnitine
boundary condition: false
notes: FORMULA: C7H15NO3 CHARGE: 0 INCHI: InChI=1S/C7H15NO3/c1-8(2,3)5-6(9)4-7(10)11/h6,9H,4-5H2,1-3H3/t6-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00270 EHMN_ABBREVIATION: C00318
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110045#_2bb561eb_8583_480f_8842_1d4976f28b12
initial concentration: NaN
initial amount: NaN
boundary condition: true
is: SBO:0000252
type: Species
is encoded by: hsa:AA788780
constant: false
name: _AA788780_1_c
has only substance units: false

metaM prist x
is: CHEBI:51340
constant: false
initial concentration: 1.0
boundary condition: false
has only substance units: false
initial amount: NaN
name: pristanic acid
is: HMDB00795
notes: FORMULA: C19H37O2 CHARGE: -1 INCHI: InChI=1S/C19H38O2/c1-15(2)9-6-10-16(3)11-7-12-17(4)13-8-14-18(5)19(20)21/h15-18H,6-14H2,1-5H3,(H,20,21)
type: Species
is: SBO:0000247

metaR EX galside hs LPAREN e RPAREN
kinetic law: MODEL1310110045#
reactant: MODEL1310110045#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: D-galactosyl-N-acylsphingosine exchange
type: Reaction

metaR H2O2t
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:2989289 NOTES:AMF
product: MODEL1310110045#
reversible: true
is: SBO:0000185
type: Reaction
fast: false
is described by: ECO:0000000
kinetic law: MODEL1310110045#
reactant: MODEL1310110045#
name: hydrogen peroxide transport via diffusion

http://identifiers.org/biomodels.db/MODEL1310110045#_becdbb11_1c17_466e_b4de_01407d8ddb09
initial concentration: NaN
is: SBO:0000252
initial amount: NaN
constant: false
is encoded by: hsa:6817
type: Species
has only substance units: false
boundary condition: true
name: SULT1A1

http://identifiers.org/biomodels.db/MODEL1310110045#_68b54583_4d08_44d1_b711_3d5a269b844a
initial concentration: NaN
type: Species
is encoded by: hsa:6567
constant: false
initial amount: NaN
has only substance units: false
boundary condition: true
is: P36021
is: SBO:0000252
name: SLC16A2

http://identifiers.org/biomodels.db/MODEL1310110045#_66eb411f_5fe2_4175_b446_8b947a264213
is: O14939
is: SBO:0000252
name: PLD2
type: Species
is encoded by: hsa:5338
has only substance units: false
initial concentration: NaN
constant: false
boundary condition: true
initial amount: NaN

metaR ADK1
kinetic law: MODEL1310110045#
notes: GENE_ASSOCIATION: (122481.1) or (203.1) or (26289.1) or (26289.2) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: NOTES:
reactant: MODEL1310110045#
type: Reaction
modifier: MODEL1310110045#
is version of: http://identifiers.org/ec-code/2.7.4.3
is: SBO:0000176
is described by: ECO:0000269
name: adenylate kinase
fast: false
reversible: true
product: MODEL1310110045#

http://identifiers.org/biomodels.db/MODEL1310110045#_16f2c937_6d62_47c9_8efa_4d938c605c12
is: SBO:0000252
is encoded by: hsa:10935
has only substance units: false
initial amount: NaN
is: E9PH29
constant: false
name: PRDX3
boundary condition: true
type: Species
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110045#_eb17bf58_f6d7_47ee_831a_fe88c419bafd
has only substance units: false
initial amount: NaN
type: Species
constant: false
initial concentration: NaN
name: BPNT1
boundary condition: true
is: O95861
is encoded by: hsa:10380
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110045#_752351a7_fbc8_4d12_ab72_81096a462708
initial amount: NaN
is: SBO:0000252
constant: false
is: Q92835
name: INPP5D
type: Species
is encoded by: hsa:3635
initial concentration: NaN
has only substance units: false
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110045#_8dde294c_25a5_44ad_9273_60e9efe2e048
initial concentration: NaN
is: SBO:0000252
boundary condition: true
name: ALDH3A1
initial amount: NaN
has only substance units: false
constant: false
is: P30838
is encoded by: hsa:218
type: Species

metaM prostgf2 e
is: HMDB01139
constant: false
notes: FORMULA: C20H33O5 CHARGE: -1 INCHI: InChI=1S/C20H34O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h4,7,12-13,15-19,21-23H,2-3,5-6,8-11,14H2,1H3,(H,24,25)/p-1/b7-4-,13-12+/t15-,16+,17+,18-,19+/m0/s1 EHMN_ABBREVIATION: C00639
is: CHEBI:57404
initial concentration: 1.0
has only substance units: false
initial amount: NaN
name: prostaglandin F2alpha(1-)
type: Species
boundary condition: false
is: SBO:0000247

metaM ala L m
is: SBO:0000247
name: L-alanine
notes: FORMULA: C3H7NO2 CHARGE: 0 INCHI: InChI=1S/C3H7NO2/c1-2(4)3(5)6/h2H,4H2,1H3,(H,5,6)/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00048
is: CHEBI:16977
has only substance units: false
initial amount: NaN
is: HMDB00161
initial concentration: 1.0
boundary condition: false
constant: false
type: Species

metaR AG13T10g
product: MODEL1310110045#
reversible: false
name: N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase, Golgi apparatus
modifier: MODEL1310110045#
reactant: MODEL1310110045#
is: SBO:0000176
fast: false
is version of: http://identifiers.org/ec-code/2.4.1.149
type: Reaction
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (79369.1) or (10678.1) or (11041.1) or (146712.1) or (374907.1) or (93010.1) or (374907.2) or (10331.1) or (10678.2) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.149 Confidence Level: 4 AUTHORS: PMID:10747980,PMID:11042166,PMID:12061784,PMID:12512857,PMID:15560372,PMID:15620693,PMID:9405606 NOTES:NCD
kinetic law: MODEL1310110045#

metaM 4aphdob c
initial amount: NaN
type: Species
constant: false
initial concentration: 1.0
is: CHEBI:58147
notes: FORMULA: C10H8NO4 CHARGE: -1 INCHI: InChI=1S/C10H9NO4/c11-7-4-2-1-3-6(7)8(12)5-9(13)10(14)15/h1-4H,5,11H2,(H,14,15)/p-1 EHMN_ABBREVIATION: C01252
is: HMDB00978
has only substance units: false
boundary condition: false
is: SBO:0000247
name: 4-(2-aminophenyl)-2,4-dioxobutanoate

metaM lald L c
name: (S)-lactaldehyde
notes: FORMULA: C3H6O2 CHARGE: 0 INCHI: InChI=1S/C3H6O2/c1-3(5)2-4/h2-3,5H,1H3/t3-/m0/s1
boundary condition: false
type: Species
is: CHEBI:18041
has only substance units: false
constant: false
is: HMDB03052
initial concentration: 1.0
initial amount: NaN
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110045#_1ff6cda9_932c_47bf_aea7_5281065bb19a
initial concentration: NaN
type: Species
is: SBO:0000252
is: P27707
has only substance units: false
name: DCK
constant: false
is encoded by: hsa:1633
initial amount: NaN
boundary condition: true

metaM sphs1p e
has only substance units: false
notes: FORMULA: C18H37NO5P CHARGE: -1 INCHI: InChI=1S/C18H38NO5P/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-18(20)17(19)16-24-25(21,22)23/h14-15,17-18,20H,2-13,16,19H2,1H3,(H2,21,22,23)/p-1/b15-14+/t17-,18+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01702 EHMN_ABBREVIATION: C06124
initial concentration: 1.0
is: CHEBI:60119
boundary condition: false
is: SBO:0000247
name: sphingosine 1-phosphate(1-)
constant: false
initial amount: NaN
type: Species
is: HMDB00277

metaR FAOXC226C225m
kinetic law: MODEL1310110045#
product: MODEL1310110045#
reactant: MODEL1310110045#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C22:6-->C22:5)m
type: Reaction

metaR P45027A11m
modifier: MODEL1310110045#
notes: GENE_ASSOCIATION: (1593.1) SUBSYSTEM: Bile acid synthesis EC Number: 1.14.13.15 Confidence Level: 4 AUTHORS: NOTES:from uniprot NJ
fast: false
type: Reaction
name: 5-beta-cholestane-3-alpha,7-alpha,12-alpha-triol 27-hydroxylase
product: MODEL1310110045#
reactant: MODEL1310110045#
is version of: http://identifiers.org/ec-code/1.14.13.15
kinetic law: MODEL1310110045#
is described by: ECO:0000269
reversible: false
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110045#_4254805b_d9ee_4db6_8b0f_cd6270681c34
is: SBO:0000252
constant: false
name: ST3GAL3
initial concentration: NaN
is encoded by: hsa:6487
has only substance units: false
boundary condition: true
initial amount: NaN
is: Q96L53
type: Species

metaR MECOALm
kinetic law: MODEL1310110045#
is described by: ECO:0000212
reactant: MODEL1310110045#
type: Reaction
notes: GENE_ASSOCIATION: (8802.1 and 8803.1) SUBSYSTEM: C5-branched dibasic acid metabolism EC Number: 6.2.1.5 Confidence Level: 1 AUTHORS: PMID:13783048 NOTES:NCD
is version of: http://identifiers.org/ec-code/6.2.1.5
is version of: http://identifiers.org/ec-code/6.2.1.4
reversible: true
is: SBO:0000176
modifier: MODEL1310110045#
product: MODEL1310110045#
fast: false
name: mesaconate--CoA ligase (ADP-forming), mitochondrial

metaR ADK3
reactant: MODEL1310110045#
type: Reaction
kinetic law: MODEL1310110045#
modifier: MODEL1310110045#
is: SBO:0000176
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (26289.1) or (26289.2) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: PMID:9434148 NOTES:JLR
is version of: http://identifiers.org/ec-code/2.7.4.3
name: adentylate kinase (GTP)
fast: false
product: MODEL1310110045#
reversible: true

metaR ME2m
kinetic law: MODEL1310110045#
name: malic enzyme (NADP), mitochondrial
is version of: http://identifiers.org/ec-code/1.1.1.40
is version of: http://identifiers.org/ec-code/1.1.1.38
product: MODEL1310110045#
fast: false
type: Reaction
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (4200.1) or (10873.1) SUBSYSTEM: Pyruvate metabolism EC Number: 1.1.1.40 Confidence Level: 0 AUTHORS: PMID:1993674 NOTES:IF
reactant: MODEL1310110045#
modifier: MODEL1310110045#
is: SBO:0000176
reversible: false

metaR EX HC02203 LPAREN e RPAREN
kinetic law: MODEL1310110045#
reactant: MODEL1310110045#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: prostaglandin-a2 exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110045#_1317caad_e318_403d_b140_9940a649fd8e
boundary condition: true
initial concentration: NaN
has only substance units: false
is: Q16842
is: SBO:0000252
constant: false
initial amount: NaN
is encoded by: hsa:6483
name: ST3GAL2
type: Species

metaR NACHEXA18ly
is version of: http://identifiers.org/ec-code/3.2.1.52
fast: false
reversible: false
is described by: ECO:0000000
modifier: MODEL1310110045#
notes: GENE_ASSOCIATION: (3073.1) or (3073.1 and 3074.1) SUBSYSTEM: Keratan sulfate degradation EC Number: Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12706724,PMID:8993162 NOTES:Note that this reaction is specific to beta-N-acetylhexosaminidase A and cannot be catalyzed by beta-N-acetylhexosaminidase B (or presumably beta-N-acetylhexosaminidase S). This is also a lumped reaction, representing the cleavage of GalNAc4S or GalNAc6S and N-acetylgalactosamine 4-sulfatase or 6-sulfatase. NCD
type: Reaction
kinetic law: MODEL1310110045#
is: SBO:0000176
reactant: MODEL1310110045#
name: beta-N-acetylhexosaminidase A, lysosomal
product: MODEL1310110045#

metaR NDP8ex
is: SBO:0000176
kinetic law: MODEL1310110045#
modifier: MODEL1310110045#
type: Reaction
notes: GENE_ASSOCIATION: (124583.1) SUBSYSTEM: Nucleotide interconversion EC Number: 3.6.1.6 Confidence Level: 4 AUTHORS: PMID:12234496,PMID:12600208 NOTES:
fast: false
is described by: ECO:0000269
product: MODEL1310110045#
reactant: MODEL1310110045#
is version of: http://identifiers.org/ec-code/3.6.1.6
name: nucleoside-diphosphatase (UTP), extracellular
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110045#_3989b52d_f342_4d8c_9251_4cd96afd7d66
initial concentration: NaN
type: Species
is: SBO:0000252
boundary condition: true
initial amount: NaN
is encoded by: hsa:AI640625
has only substance units: false
name: _AI640625_1_c
constant: false

metaM glu5sa m
initial concentration: 1.0
has only substance units: false
is: C01165
is: HMDB02104
is: SBO:0000247
boundary condition: false
initial amount: NaN
is: CHEBI:17232
name: L-Glutamate 5-semialdehyde
constant: false
notes: FORMULA: C5H9NO3 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00694 EHMN_ABBREVIATION: C01165
type: Species

metaR EX c4crn
kinetic law: MODEL1310110045#
reactant: MODEL1310110045#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for butyryl carnitine
type: Reaction

metaR r0186
kinetic law: MODEL1310110045#
reactant: MODEL1310110045#
name: Ethanolamine-phosphate phospho-lyase (deaminating) EC:4.2.3.2
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.2.1.5
notes: GENE_ASSOCIATION: (220.1) or (218.1) or (221.1) or (222.1) or (U37519.1) SUBSYSTEM: Glycerophospholipid metabolism EC Number: 4.2.3.2 Confidence Level: 0 AUTHORS: PMID:5498429 NOTES:
is described by: ECO:0000000
modifier: MODEL1310110045#
fast: false
reversible: false
product: MODEL1310110045#
type: Reaction

metaM ach c
has only substance units: false
initial concentration: 1.0
boundary condition: false
type: Species
initial amount: NaN
is: HMDB00895
is: CHEBI:15355
is: SBO:0000247
constant: false
notes: FORMULA: C7H16NO2 CHARGE: 1 INCHI: InChI=1S/C7H16NO2/c1-7(9)10-6-5-8(2,3)4/h5-6H2,1-4H3/q+1 HEPATONET_1.0_ABBREVIATION: HC00877 EHMN_ABBREVIATION: C01996
name: acetylcholine

metaM ksi deg20 l
notes: FORMULA: C138H223N9O119S6 CHARGE: -6
initial amount: NaN
name: keratan sulfate I, degradation product 20
is: SBO:0000247
boundary condition: false
has only substance units: false
constant: false
type: Species
initial concentration: 1.0
is: CHEBI:12936
is: HMDB00143

http://identifiers.org/biomodels.db/MODEL1310110045#_b75e26a3_27c7_4cdc_a7c9_1d55ad0ee794
initial concentration: NaN
is encoded by: hsa:6821
has only substance units: false
initial amount: NaN
is: SBO:0000252
type: Species
constant: false
name: SUOX
boundary condition: true
is: P51687

metaM btn e
is: HMDB00030
type: Species
has only substance units: false
initial amount: NaN
notes: FORMULA: C10H15N2O3S CHARGE: -1
name: Biotin
is: C00120
boundary condition: false
constant: false
is: CHEBI:3420
is: SBO:0000247
initial concentration: 1.0

metaR CYTK7n
is: SBO:0000176
modifier: MODEL1310110045#
is version of: http://identifiers.org/ec-code/2.7.4.14
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
product: MODEL1310110045#
reversible: true
kinetic law: MODEL1310110045#
type: Reaction
fast: false
is described by: ECO:0000269
name: cytidylate kinase (CMP,UTP),nuclear
reactant: MODEL1310110045#

metaR RE1796M
fast: false
reversible: true
reactant: MODEL1310110045#
is version of: http://identifiers.org/ec-code/1.1.1.145
modifier: MODEL1310110045#
product: MODEL1310110045#
is: SBO:0000176
type: Reaction
is described by: ECO:0000000
kinetic law: MODEL1310110045#
notes: GENE_ASSOCIATION: (3283.1) or (3284.1) SUBSYSTEM: Bile acid synthesis EC Number: 5.3.3.1 Confidence Level: 0 AUTHORS: PMID:10599696,PMID:11067870,PMID:11454857,PMID:1401999 NOTES:
name: RE1796

metaM ump r
constant: false
initial concentration: 1.0
boundary condition: false
type: Species
name: UMP
initial amount: NaN
notes: FORMULA: C9H11N2O9P CHARGE: -2 INCHI: InChI=1S/C9H13N2O9P/c12-5-1-2-11(9(15)10-5)8-7(14)6(13)4(20-8)3-19-21(16,17)18/h1-2,4,6-8,13-14H,3H2,(H,10,12,15)(H2,16,17,18)/p-2/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00105 EHMN_ABBREVIATION: C00105
is: SBO:0000247
has only substance units: false
is: CHEBI:57865
is: HMDB00288

metaR RE2349C
is: SBO:0000176
is described by: ECO:0000000
product: MODEL1310110045#
reversible: true
name: RE2349
notes: GENE_ASSOCIATION: (883.1) SUBSYSTEM: Tryptophan metabolism EC Number: 2.6.1.7 Confidence Level: 0 AUTHORS: PMID:10559215,PMID:8908429 NOTES:IT - removed H[c] on right hand side even though no charged formula for Kegg compound but same as reaction RE1233C
type: Reaction
kinetic law: MODEL1310110045#
reactant: MODEL1310110045#
fast: false
modifier: MODEL1310110045#
is version of: http://identifiers.org/ec-code/2.6.1.64

metaR EX hdca LPAREN e RPAREN
kinetic law: MODEL1310110045#
reactant: MODEL1310110045#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Hexadecanoate (n-C16:0) exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110045#_587abede_bc03_4213_b2a2_02c72e8cc246
boundary condition: true
constant: false
initial concentration: NaN
type: Species
name: DGUOK
has only substance units: false
initial amount: NaN
is encoded by: hsa:1716
is: SBO:0000252

metaR GALASE13ly
modifier: MODEL1310110045#
is version of: http://identifiers.org/ec-code/3.1.6.4
is: SBO:0000176
kinetic law: MODEL1310110045#
is version of: http://identifiers.org/ec-code/3.2.1.18
fast: false
is version of: http://identifiers.org/ec-code/3.4.16.5
reactant: MODEL1310110045#
name: beta-galactosidase, lysosomal
is described by: ECO:0000000
reversible: false
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) or (5476.1) and (2720.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.23 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD
type: Reaction
is version of: http://identifiers.org/ec-code/3.2.1.23
product: MODEL1310110045#

metaR FATP8t
is: SBO:0000185
is described by: ECO:0000269
fast: false
type: Reaction
kinetic law: MODEL1310110045#
reactant: MODEL1310110045#
is version of: http://identifiers.org/ec-code/6.2.1.3
name: fatty acid electroneutral transport
is version of: http://identifiers.org/ec-code/6.2.1.7
product: MODEL1310110045#
modifier: MODEL1310110045#
notes: GENE_ASSOCIATION: (10998.1) or (11001.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10479480,PMID:12856180,PMID:15522816 NOTES:electroneutral transport NJ
reversible: true

metaM ascb L c
is: SBO:0000247
has only substance units: false
notes: FORMULA: C6H7O6 CHARGE: -1 INCHI: InChI=1S/C6H8O6/c7-1-2(8)5-3(9)4(10)6(11)12-5/h2,5,7-10H,1H2/p-1/t2-,5+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00074
is: HMDB00044
boundary condition: false
initial concentration: 1.0
constant: false
name: L-ascorbate
initial amount: NaN
is: CHEBI:38290
type: Species

metaR EX ala D LPAREN e RPAREN
kinetic law: MODEL1310110045#
reactant: MODEL1310110045#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: D-Alanine exchange
type: Reaction

metaM fru c
initial amount: NaN
is: HMDB00660
is: CHEBI:15824
constant: false
has only substance units: false
initial concentration: 1.0
notes: FORMULA: C6H12O6 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00097 EHMN_ABBREVIATION: C00095
name: D-Fructose
boundary condition: false
is: C00095
type: Species
is: SBO:0000247

metaR RE3074X
is version of: http://identifiers.org/ec-code/6.2.1.3
name: RE3074
kinetic law: MODEL1310110045#
is: SBO:0000176
type: Reaction
is described by: ECO:0000000
reactant: MODEL1310110045#
notes: GENE_ASSOCIATION: (11001.1) or (2182.1) or (2181.1) or (2180.1) or (51703.1) or (23305.1) SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 0 AUTHORS: PMID:11060359,PMID:11356164 NOTES:IT - fixed proton
fast: false
modifier: MODEL1310110045#
reversible: true
product: MODEL1310110045#

metaM val L e
constant: false
type: Species
is: CHEBI:16414
boundary condition: false
is: HMDB00883
name: L-valine
is: SBO:0000247
initial amount: NaN
notes: FORMULA: C5H11NO2 CHARGE: 0 INCHI: InChI=1S/C5H11NO2/c1-3(2)4(6)5(7)8/h3-4H,6H2,1-2H3,(H,7,8)/t4-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00174
initial concentration: 1.0
has only substance units: false

metaR ASPTA
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (2805.1) SUBSYSTEM: Alanine and aspartate metabolism EC Number: 2.6.1.1 Confidence Level: 4 AUTHORS: PMID:2225456,PMID:6930651 NOTES:
kinetic law: MODEL1310110045#
is: SBO:0000176
name: aspartate transaminase
modifier: MODEL1310110045#
product: MODEL1310110045#
fast: false
reversible: true
is version of: http://identifiers.org/ec-code/2.6.1.1
reactant: MODEL1310110045#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110045#_95463fd2_fa04_456e_ae08_00531c8f948e
initial amount: NaN
constant: false
type: Species
initial concentration: NaN
name: NDUFV2
is encoded by: hsa:4729
boundary condition: true
has only substance units: false
is: SBO:0000252
is: P19404

http://identifiers.org/biomodels.db/MODEL1310110045#_0356eb9f_9f30_4540_bd16_33099694f3f1
is encoded by: hsa:4726
initial concentration: NaN
has only substance units: false
is: SBO:0000252
name: NDUFS6
initial amount: NaN
constant: false
boundary condition: true
type: Species
is: Q6IBC4

metaM 25aics c
boundary condition: false
notes: FORMULA: C13H15N4O12P CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC01356 EHMN_ABBREVIATION: C04823
constant: false
name: (S)-2-[5-Amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamido]succinate
is: SBO:0000247
has only substance units: false
is: HMDB00797
initial concentration: 1.0
initial amount: NaN
is: CHEBI:58443
is: C04823
type: Species

metaM crn m
name: L-Carnitine
is: SBO:0000247
boundary condition: false
is: C00318
initial concentration: 1.0
initial amount: NaN
has only substance units: false
constant: false
is: HMDB00062
is: CHEBI:16347
notes: FORMULA: C7H15NO3 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00270 EHMN_ABBREVIATION: C00318
type: Species

metaR EX urate LPAREN e RPAREN
kinetic law: MODEL1310110045#
reactant: MODEL1310110045#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Urate exchange
type: Reaction

metaR CHOLtn
is: SBO:0000185
fast: false
product: MODEL1310110045#
reactant: MODEL1310110045#
reversible: true
name: Choline transport, nuclear through pores
type: Reaction
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: NOTES:it
kinetic law: MODEL1310110045#

metaM btn c
has only substance units: false
is: CHEBI:3420
is: HMDB00030
is: SBO:0000247
notes: FORMULA: C10H15N2O3S CHARGE: -1
type: Species
name: Biotin
initial amount: NaN
is: C00120
boundary condition: false
initial concentration: 1.0
constant: false

metaR ALADGLNexR
type: Reaction
is: SBO:0000185
notes: GENE_ASSOCIATION: (56301.1) and (6520.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10734121,PMID:10863037,PMID:14770310 NOTES:
kinetic law: MODEL1310110045#
modifier: MODEL1310110045#
fast: false
is described by: ECO:0000304
reactant: MODEL1310110045#
reversible: true
name: L-alanine/glutamine reversible exchange
product: MODEL1310110045#

metaR RE1534M
type: Reaction
is version of: http://identifiers.org/ec-code/4.2.1.17
reactant: MODEL1310110045#
modifier: MODEL1310110045#
reversible: true
notes: GENE_ASSOCIATION: (10449.1) or (3032.1) or (3030.1) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.16 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:7923814,PMID:9568246,PMID:9920399 NOTES:
product: MODEL1310110045#
kinetic law: MODEL1310110045#
is: SBO:0000176
fast: false
is version of: http://identifiers.org/ec-code/2.3.1.16
name: RE1534
is described by: ECO:0000000

metaR N3Tg
product: MODEL1310110045#
reversible: false
modifier: MODEL1310110045#
fast: false
notes: GENE_ASSOCIATION: (56913.1) SUBSYSTEM: O-glycan synthesis EC Number: 2.4.1.122 Confidence Level: 0 AUTHORS: PMID:11677243 NOTES:NCD
name: N-acetylgalactosamine 3-beta-galactosyltransferase, Golgi apparatus
is version of: http://identifiers.org/ec-code/2.4.1.122
is described by: ECO:0000000
type: Reaction
kinetic law: MODEL1310110045#
is: SBO:0000176
reactant: MODEL1310110045#

metaR r2071
modifier: MODEL1310110045#
type: Reaction
is described by: ECO:0000000
is: SBO:0000185
kinetic law: MODEL1310110045#
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
fast: false
reversible: false
product: MODEL1310110045#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.15
reactant: MODEL1310110045#

metaR PPA
notes: GENE_ASSOCIATION: (5464.1) SUBSYSTEM: Oxidative phosphorylation EC Number: 3.6.1.1 Confidence Level: 4 AUTHORS: PMID:10542310,PMID:15533045 NOTES:
name: inorganic diphosphatase
product: MODEL1310110045#
reactant: MODEL1310110045#
type: Reaction
is described by: ECO:0000269
kinetic law: MODEL1310110045#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.6.1.1
reversible: false
modifier: MODEL1310110045#
fast: false

metaM succ x
type: Species
is: HMDB00254
constant: false
initial concentration: 1.0
name: Succinate
boundary condition: false
has only substance units: false
is: CHEBI:30031
notes: FORMULA: C4H4O4 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00049 EHMN_ABBREVIATION: C00042
is: SBO:0000247
initial amount: NaN
is: C00042

metaM HC01409 m
is: CHEBI:27540
has only substance units: false
constant: false
type: Species
notes: FORMULA: C27H42N7O17P3S CHARGE: -4 INCHI: InChI=1S/C27H46N7O17P3S/c1-4-5-6-7-18(36)55-11-10-29-17(35)8-9-30-25(39)22(38)27(2,3)13-48-54(45,46)51-53(43,44)47-12-16-21(50-52(40,41)42)20(37)26(49-16)34-15-33-19-23(28)31-14-32-24(19)34/h14-16,20-22,26,37-38H,4-13H2,1-3H3,(H,29,35)(H,30,39)(H,43,44)(H,45,46)(H2,28,31,32)(H2,40,41,42)/t16-,20-,21-,22+,26-/m1/s1 EHMN_ABBREVIATION: C05270
name: Hexanoyl-CoA
initial concentration: 1.0
initial amount: NaN
is: SBO:0000247
boundary condition: false

metaM ascb L e
is: HMDB00044
type: Species
notes: FORMULA: C6H7O6 CHARGE: -1 INCHI: InChI=1S/C6H8O6/c7-1-2(8)5-3(9)4(10)6(11)12-5/h2,5,7-10H,1H2/p-1/t2-,5+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00074
is: SBO:0000247
initial concentration: 1.0
initial amount: NaN
is: CHEBI:38290
name: L-ascorbate
constant: false
has only substance units: false
boundary condition: false

metaM fru e
is: CHEBI:15824
notes: FORMULA: C6H12O6 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00097 EHMN_ABBREVIATION: C00095
type: Species
is: SBO:0000247
name: D-Fructose
boundary condition: false
initial concentration: 1.0
constant: false
is: C00095
initial amount: NaN
is: HMDB00660
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110045#_1eb148f1_ea3c_4a3c_a413_ae52532c02ee
has only substance units: false
is: Q96CD2
is: SBO:0000252
is encoded by: hsa:60490
boundary condition: true
name: PPCDC
type: Species
initial amount: NaN
initial concentration: NaN
constant: false

metaR r1467
is described by: ECO:0000000
type: Reaction
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: 2.3.1.86 Confidence Level: 0 AUTHORS: NOTES:
reversible: true
name: Postulated transport reaction
product: MODEL1310110045#
fast: false
kinetic law: MODEL1310110045#
reactant: MODEL1310110045#

http://identifiers.org/biomodels.db/MODEL1310110045#_eed04054_8846_4289_95d9_e13f610599eb
type: Species
constant: false
is encoded by: hsa:226
has only substance units: false
is: P04075
name: ALDOA
is: SBO:0000252
initial amount: NaN
initial concentration: NaN
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110045#_0ba1227f_1d22_481e_9813_1303990c2d2a
initial concentration: NaN
is encoded by: hsa:728441
constant: false
boundary condition: true
initial amount: NaN
is: SBO:0000252
name: GGT2
has only substance units: false
type: Species

metaR PHCDm
is version of: http://identifiers.org/ec-code/1.5.1.12
reactant: MODEL1310110045#
fast: false
kinetic law: MODEL1310110045#
is described by: ECO:0000304
type: Reaction
reversible: false
name: L-1-pyrroline-3-hydroxy-5-carboxylate dehydrogenase
product: MODEL1310110045#
is: SBO:0000176
notes: GENE_ASSOCIATION: (8659.1) or (8659.2) SUBSYSTEM: Arginine and Proline Metabolism EC Number: 1.5.1.12 Confidence Level: 2 AUTHORS: PMID:12660328,PMID:15849464,PMID:500817 NOTES:NCD
modifier: MODEL1310110045#

metaM L2aadp c
name: L-2-aminoadipate(1-)
constant: false
notes: FORMULA: C6H10NO4 CHARGE: -1 INCHI: InChI=1S/C6H11NO4/c7-4(6(10)11)2-1-3-5(8)9/h4H,1-3,7H2,(H,8,9)(H,10,11)/p-1/t4-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00599 EHMN_ABBREVIATION: C00956
initial amount: NaN
type: Species
boundary condition: false
initial concentration: 1.0
is: HMDB00510
has only substance units: false
is: SBO:0000247
is: CHEBI:58672

metaR MI1PP
modifier: MODEL1310110045#
product: MODEL1310110045#
reversible: false
name: myo-inositol 1-phosphatase
fast: false
is: SBO:0000176
is described by: ECO:0000269
reactant: MODEL1310110045#
is version of: http://identifiers.org/ec-code/3.1.3.25
kinetic law: MODEL1310110045#
type: Reaction
notes: GENE_ASSOCIATION: (3612.1) or (3613.1) SUBSYSTEM: Inositol phosphate metabolism EC Number: 3.1.3.25 Confidence Level: 4 AUTHORS: PMID:1377913,PMID:2906139,PMID:9322233 NOTES:JLR

metaM ach e
initial concentration: 1.0
is: HMDB00895
has only substance units: false
name: acetylcholine
constant: false
type: Species
is: SBO:0000247
initial amount: NaN
is: CHEBI:15355
boundary condition: false
notes: FORMULA: C7H16NO2 CHARGE: 1 INCHI: InChI=1S/C7H16NO2/c1-7(9)10-6-5-8(2,3)4/h5-6H2,1-4H3/q+1 HEPATONET_1.0_ABBREVIATION: HC00877 EHMN_ABBREVIATION: C01996

metaM leuktrE4 c
type: Species
constant: false
initial concentration: 1.0
name: leukotriene E4(1-)
initial amount: NaN
is: SBO:0000247
boundary condition: false
is: CHEBI:57462
notes: FORMULA: C23H36NO5S CHARGE: -1 INCHI: InChI=1S/C23H37NO5S/c1-2-3-4-5-6-7-8-9-10-11-12-13-16-21(30-18-19(24)23(28)29)20(25)15-14-17-22(26)27/h6-7,9-13,16,19-21,25H,2-5,8,14-15,17-18,24H2,1H3,(H,26,27)(H,28,29)/p-1/b7-6-,10-9-,12-11+,16-13+/t19-,20-,21+/m0/s1 EHMN_ABBREVIATION: C05952
is: HMDB02200
has only substance units: false

metaM gly e
initial amount: NaN
type: Species
initial concentration: 1.0
boundary condition: false
is: CHEBI:3339
name: Glycine
has only substance units: false
is: C00037
constant: false
notes: FORMULA: C2H5NO2 CHARGE: 0
is: HMDB00123
is: SBO:0000247

metaR NACHEXA11ly
modifier: MODEL1310110045#
is: SBO:0000176
name: beta-N-acetylhexosaminidase A, lysosomal
reversible: false
notes: GENE_ASSOCIATION: (3073.1) or (3073.1 and 3074.1) SUBSYSTEM: Keratan sulfate degradation EC Number: Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12706724,PMID:8993162 NOTES:Note that this reaction is specific to beta-N-acetylhexosaminidase A and cannot be catalyzed by beta-N-acetylhexosaminidase B (or presumably beta-N-acetylhexosaminidase S). This is also a lumped reaction, representing the cleavage of GalNAc4S or GalNAc6S and N-acetylgalactosamine 4-sulfatase or 6-sulfatase. NCD
type: Reaction
product: MODEL1310110045#
kinetic law: MODEL1310110045#
is version of: http://identifiers.org/ec-code/3.2.1.52
reactant: MODEL1310110045#
fast: false
is described by: ECO:0000000

metaM ala L c
initial concentration: 1.0
initial amount: NaN
name: L-alanine
is: SBO:0000247
boundary condition: false
is: CHEBI:16977
type: Species
constant: false
notes: FORMULA: C3H7NO2 CHARGE: 0 INCHI: InChI=1S/C3H7NO2/c1-2(4)3(5)6/h2H,4H2,1H3,(H,5,6)/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00048
has only substance units: false
is: HMDB00161

metaR APOCF
reactant: MODEL1310110045#
kinetic law: MODEL1310110045#
product: MODEL1310110045#
type: Reaction
is described by: ECO:0000000
is: SBO:0000176
reversible: false
name: Apocarboxylase formation
notes: GENE_ASSOCIATION: SUBSYSTEM: Biotin metabolism EC Number: Confidence Level: 2 AUTHORS: PMID:10191093 NOTES:IT faked reaction to balance reaction in human biotin metabolism
fast: false

metaR r1551
reversible: true
is: SBO:0000185
product: MODEL1310110045#
reactant: MODEL1310110045#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
type: Reaction
kinetic law: MODEL1310110045#
fast: false
is described by: ECO:0000000

metaR ILETAm
fast: false
reversible: true
type: Reaction
modifier: MODEL1310110045#
is described by: ECO:0000269
kinetic law: MODEL1310110045#
product: MODEL1310110045#
is version of: http://identifiers.org/ec-code/2.6.1.42
is: SBO:0000176
reactant: MODEL1310110045#
notes: GENE_ASSOCIATION: (587.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 2.6.1.42 Confidence Level: 4 AUTHORS: PMID:6933702,PMID:9165094 NOTES:NCD
name: isoleucine transaminase, mitochondrial

metaM gdp c
boundary condition: false
is: C00035
constant: false
is: HMDB01201
has only substance units: false
name: GDP
notes: FORMULA: C10H12N5O11P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00043 EHMN_ABBREVIATION: C00035
is: CHEBI:58189
type: Species
initial amount: NaN
is: SBO:0000247
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110045#_f60af82c_1237_4d00_946f_9d464f7ca2a7
initial amount: NaN
name: _AI694761_1_c
type: Species
initial concentration: NaN
boundary condition: true
has only substance units: false
constant: false
is: SBO:0000252
is encoded by: hsa:AI694761

metaR ICDHyrm
reactant: MODEL1310110045#
product: MODEL1310110045#
is version of: http://identifiers.org/ec-code/1.1.1.42
notes: GENE_ASSOCIATION: (3418.1) SUBSYSTEM: Citric acid cycle EC Number: 1.1.1.42 Confidence Level: 4 AUTHORS: PMID:12234803,PMID:8187868 NOTES:The reaction may be reversible. Strathern shows the reaction as irreversible. IF
reversible: true
kinetic law: MODEL1310110045#
type: Reaction
modifier: MODEL1310110045#
is: SBO:0000176
fast: false
name: Isocitrate dehydrogenase (NADP+)
is described by: ECO:0000269

http://identifiers.org/biomodels.db/MODEL1310110045#_9792b64a_0807_47ec_b402_bd962a2e19be
initial concentration: NaN
is: SBO:0000252
constant: false
boundary condition: true
is: Q86V21
name: AACS
initial amount: NaN
has only substance units: false
is encoded by: hsa:65985
type: Species

metaM 5mthf c
is: C00440
type: Species
has only substance units: false
notes: FORMULA: C20H24N7O6 CHARGE: -1
initial amount: NaN
is: HMDB01396
constant: false
initial concentration: 1.0
boundary condition: false
is: CHEBI:3729
is: SBO:0000247
name: 5-Methyltetrahydrofolate

metaR GLCURter
reversible: false
product: MODEL1310110045#
kinetic law: MODEL1310110045#
name: glucuronate endoplasmic reticular transport
fast: false
reactant: MODEL1310110045#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD
is described by: ECO:0000000
type: Reaction
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110045#_271dbaf8_09e7_402c_985c_2842d3c66996
constant: false
is encoded by: hsa:54963
initial amount: NaN
is: Q53HM1
is: SBO:0000252
has only substance units: false
type: Species
name: UCKL1
initial concentration: NaN
boundary condition: true

metaM arachcrn m
is: SBO:0000247
is: HMDB06460
has only substance units: false
type: Species
initial concentration: 1.0
constant: false
notes: FORMULA: C27H53NO4 CHARGE: 0 INCHI: InChI=1/C27H53NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-27(31)32-25(23-26(29)30)24-28(2,3)4/h25H,5-24H2,1-4H3
initial amount: NaN
name: arachidyl carnitine
boundary condition: false

metaM ump n
initial concentration: 1.0
notes: FORMULA: C9H11N2O9P CHARGE: -2 INCHI: InChI=1S/C9H13N2O9P/c12-5-1-2-11(9(15)10-5)8-7(14)6(13)4(20-8)3-19-21(16,17)18/h1-2,4,6-8,13-14H,3H2,(H,10,12,15)(H2,16,17,18)/p-2/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00105 EHMN_ABBREVIATION: C00105
is: HMDB00288
has only substance units: false
constant: false
boundary condition: false
is: CHEBI:57865
type: Species
initial amount: NaN
is: SBO:0000247
name: UMP(2-)

http://identifiers.org/biomodels.db/MODEL1310110045#_631ff1d5_9536_41f7_b4a2_eb7e6ecaacbc
is: SBO:0000252
has only substance units: false
name: UPP2
is: O95045
initial concentration: NaN
is encoded by: hsa:151531
constant: false
boundary condition: true
initial amount: NaN
type: Species

metaR ALAGLNexR
is described by: ECO:0000304
name: L-alanine/glutamine reversible exchange
reversible: true
reactant: MODEL1310110045#
kinetic law: MODEL1310110045#
product: MODEL1310110045#
fast: false
type: Reaction
modifier: MODEL1310110045#
is: SBO:0000185
notes: GENE_ASSOCIATION: (6520.1) and (56301.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10734121,PMID:10863037,PMID:14770310 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110045#_02119706_008a_4884_a4dd_bbdbfbecb022
has only substance units: false
type: Species
constant: false
is encoded by: hsa:27068
initial amount: NaN
name: PPA2
is: SBO:0000252
initial concentration: NaN
boundary condition: true

metaM 5mta c
has only substance units: false
notes: FORMULA: C11H15N5O3S CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00165 EHMN_ABBREVIATION: C00170
is: SBO:0000247
initial concentration: 1.0
boundary condition: false
name: 5-Methylthioadenosine
is: C00170
constant: false
is: HMDB01173
is: CHEBI:17509
initial amount: NaN
type: Species

metaM 4fumacac c
has only substance units: false
initial amount: NaN
constant: false
boundary condition: false
name: 4-fumarylacetoacetate(2-)
is: SBO:0000247
type: Species
initial concentration: 1.0
notes: FORMULA: C8H6O6 CHARGE: -2 INCHI: InChI=1S/C8H8O6/c9-5(1-2-7(11)12)3-6(10)4-8(13)14/h1-2H,3-4H2,(H,11,12)(H,13,14)/p-2/b2-1+ HEPATONET_1.0_ABBREVIATION: HC00648 EHMN_ABBREVIATION: C01061
is: CHEBI:18034
is: HMDB01268

metaR CHOLtr
name: choline intracellular transport
product: MODEL1310110045#
reversible: true
fast: false
reactant: MODEL1310110045#
type: Reaction
is described by: ECO:0000000
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: NOTES:unknown mechanism NJ
kinetic law: MODEL1310110045#

http://identifiers.org/biomodels.db/MODEL1310110045#_45ec606f_7c85_4d0c_9b43_f43cd9ab7132
constant: false
type: Species
is: SBO:0000252
boundary condition: true
has only substance units: false
is: B2RBR4
initial amount: NaN
name: SLC20A2
is encoded by: hsa:6575
initial concentration: NaN

metaR BIOCYTtn
name: biocytin transport, nuclear
is described by: ECO:0000000
type: Reaction
reactant: MODEL1310110045#
fast: false
kinetic law: MODEL1310110045#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: PMID:16011464,PMID:5867120,PMID:7758201,PMID:8593541 NOTES:IT
product: MODEL1310110045#
reversible: true

metaM dgsn m
name: Deoxyguanosine
is: SBO:0000247
initial concentration: 1.0
boundary condition: false
type: Species
is: C00330
notes: FORMULA: C10H13N5O4 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00280 EHMN_ABBREVIATION: C00330
has only substance units: false
constant: false
is: HMDB00085
initial amount: NaN
is: CHEBI:17172

http://identifiers.org/biomodels.db/MODEL1310110045#_e01f983d_f2e0_4653_a0f0_968b0e428de3
has only substance units: false
name: PPA2
is encoded by: hsa:27068
constant: false
type: Species
initial amount: NaN
boundary condition: true
is: SBO:0000252
initial concentration: NaN
is: Q9H2U2

metaM gly c
is: SBO:0000247
initial concentration: 1.0
type: Species
boundary condition: false
has only substance units: false
name: Glycine
initial amount: NaN
is: CHEBI:3339
notes: FORMULA: C2H5NO2 CHARGE: 0
is: C00037
constant: false
is: HMDB00123

metaM leuktrE4 e
constant: false
type: Species
has only substance units: false
initial amount: NaN
is: SBO:0000247
initial concentration: 1.0
is: CHEBI:57462
is: HMDB02200
name: leukotriene E4(1-)
boundary condition: false
notes: FORMULA: C23H36NO5S CHARGE: -1 INCHI: InChI=1S/C23H37NO5S/c1-2-3-4-5-6-7-8-9-10-11-12-13-16-21(30-18-19(24)23(28)29)20(25)15-14-17-22(26)27/h6-7,9-13,16,19-21,25H,2-5,8,14-15,17-18,24H2,1H3,(H,26,27)(H,28,29)/p-1/b7-6-,10-9-,12-11+,16-13+/t19-,20-,21+/m0/s1 EHMN_ABBREVIATION: C05952

metaM g1m8masn r
is: SBO:0000247
initial concentration: 1.0
has only substance units: false
name: (alpha-D-Glucosyl)-(alpha-D-mannosyl)8-beta-D-mannosyl-diacetylchitobiosyl-L-asparagine (protein)
is: C05875
notes: FORMULA: C76H127N2O60X CHARGE: 0
initial amount: NaN
constant: false
type: Species
boundary condition: false

metaR r1553
is: SBO:0000185
reversible: true
reactant: MODEL1310110045#
product: MODEL1310110045#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is described by: ECO:0000000
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
fast: false
kinetic law: MODEL1310110045#

metaR MI1PS
name: myo-Inositol-1-phosphate synthase
reactant: MODEL1310110045#
is version of: http://identifiers.org/ec-code/5.5.1.4
reversible: false
notes: GENE_ASSOCIATION: (51477.1) SUBSYSTEM: Inositol phosphate metabolism EC Number: 5.5.1.4 Confidence Level: 4 AUTHORS: PMID:12941308 NOTES:NCD
fast: false
product: MODEL1310110045#
is: SBO:0000176
kinetic law: MODEL1310110045#
is described by: ECO:0000269
type: Reaction
modifier: MODEL1310110045#

metaM ala L e
has only substance units: false
initial concentration: 1.0
initial amount: NaN
is: SBO:0000247
is: CHEBI:16977
boundary condition: false
constant: false
name: L-alanine
type: Species
notes: FORMULA: C3H7NO2 CHARGE: 0 INCHI: InChI=1S/C3H7NO2/c1-2(4)3(5)6/h2H,4H2,1H3,(H,5,6)/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00048
is: HMDB00161

http://identifiers.org/biomodels.db/MODEL1310110045#_11c25c63_3f8e_41dd_9eac_587546d02c6c
type: Species
initial amount: NaN
constant: false
has only substance units: false
initial concentration: NaN
is: Q6P1K9
is: SBO:0000252
is encoded by: hsa:80025
name: PANK2
boundary condition: true

metaR r0085
reactant: MODEL1310110045#
kinetic law: MODEL1310110045#
is: SBO:0000176
product: MODEL1310110045#
reversible: false
type: Reaction
name: 2-Oxoglutaramate amidohydrolase Glutamate metabolism EC:3.5.1.3
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (AI971036.1) or (3417.1) or (3418.1) SUBSYSTEM: Urea cycle EC Number: 3.5.1.3 Confidence Level: 0 AUTHORS: PMID:3003502,PMID:319948,PMID:4436326,PMID:5114531,PMID:894284 NOTES:
fast: false
is version of: http://identifiers.org/ec-code/1.1.1.42
modifier: MODEL1310110045#

metaM 5mthf e
is: SBO:0000247
has only substance units: false
is: C00440
initial amount: NaN
boundary condition: false
name: 5-Methyltetrahydrofolate
type: Species
initial concentration: 1.0
is: HMDB01396
constant: false
is: CHEBI:3729
notes: FORMULA: C20H24N7O6 CHARGE: -1

metaR r1464
is: SBO:0000185
kinetic law: MODEL1310110045#
product: MODEL1310110045#
type: Reaction
reactant: MODEL1310110045#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: 1.3.1.27 Confidence Level: 0 AUTHORS: NOTES:
reversible: true
name: Active transport
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110045#_645f57f3_1732_4eb4_b0bb_ad59c6ea5668
is encoded by: hsa:224
name: ALDH3A2
type: Species
has only substance units: false
initial amount: NaN
initial concentration: NaN
is: P51648
boundary condition: true
constant: false
is: SBO:0000252

metaR FAOXC204C184m
kinetic law: MODEL1310110045#
product: MODEL1310110045#
reactant: MODEL1310110045#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C20:4-->C18:4)m
type: Reaction

metaR FAOXC2252053m
is described by: ECO:0000000
fast: false
is version of: http://identifiers.org/ec-code/1.3.8.1
is version of: http://identifiers.org/ec-code/1.3.99.3
is: SBO:0000176
product: MODEL1310110045#
type: Reaction
reactant: MODEL1310110045#
kinetic law: MODEL1310110045#
reversible: false
name: Beta oxidation of long chain fatty acid
modifier: MODEL1310110045#
notes: GENE_ASSOCIATION: (35.1) or (34.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.74 Confidence Level: 4 AUTHORS: NOTES:_1 round beta ox - c22:5,n-3 -> c20:5, n-3 - final '3' in abbreviation indicates omega3 FA 4 step FAO lumped for 2 rounds also includes EC 1.1.1.35, 1.1.1.211, 1.3.3.6, 4.2.1.17, 4.2.1.74 NJ

http://identifiers.org/biomodels.db/MODEL1310110045#_fa9ccbbc_2298_46e9_be6e_cfabe5b433eb
is encoded by: hsa:18
constant: false
is: SBO:0000252
initial amount: NaN
initial concentration: NaN
type: Species
is: P80404
boundary condition: true
has only substance units: false
name: ABAT

metaM prostgd2 c
is: SBO:0000247
initial concentration: 1.0
initial amount: NaN
is: CHEBI:57406
is: HMDB01403
type: Species
notes: FORMULA: C20H31O5 CHARGE: -1 INCHI: InChI=1S/C20H32O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h4,7,12-13,15-18,21-22H,2-3,5-6,8-11,14H2,1H3,(H,24,25)/p-1/b7-4-,13-12+/t15-,16+,17+,18-/m0/s1 EHMN_ABBREVIATION: C00696
boundary condition: false
has only substance units: false
name: prostaglandin D2(1-)
constant: false

metaM 5mta e
initial concentration: 1.0
type: Species
is: C00170
notes: FORMULA: C11H15N5O3S CHARGE: 0
is: SBO:0000247
name: 5-Methylthioadenosine
initial amount: NaN
is: HMDB01173
is: CHEBI:17509
has only substance units: false
constant: false
boundary condition: false

metaR r1552
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
type: Reaction
is: SBO:0000185
product: MODEL1310110045#
reactant: MODEL1310110045#
is described by: ECO:0000000
reversible: true
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
kinetic law: MODEL1310110045#

metaR AATAi
is: SBO:0000176
product: MODEL1310110045#
reversible: false
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/2.6.1.7
fast: false
name: 2-aminoadipate transaminase, irreversible
notes: GENE_ASSOCIATION: (51166.1) or (51166.2) SUBSYSTEM: Lysine metabolism EC Number: 2.6.1.39 Confidence Level: 4 AUTHORS: PMID:12126930 NOTES:MM
type: Reaction
kinetic law: MODEL1310110045#
modifier: MODEL1310110045#
reactant: MODEL1310110045#

http://identifiers.org/biomodels.db/MODEL1310110045#_430be562_551b_4659_afdb_766fd4517a7b
initial concentration: NaN
is encoded by: hsa:217
is: P05091
has only substance units: false
type: Species
is: SBO:0000252
boundary condition: true
name: ALDH2
constant: false
initial amount: NaN

metaR 5MTAte
is: SBO:0000185
fast: false
name: Transport of 5-S-methyl-5-thioadenosine
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
reactant: MODEL1310110045#
reversible: true
is described by: ECO:0000134
product: MODEL1310110045#
kinetic law: MODEL1310110045#
type: Reaction

metaR FAOXC14C12x
kinetic law: MODEL1310110045#
product: MODEL1310110045#
reactant: MODEL1310110045#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C14-->C12)x
type: Reaction

metaR DM pmtcoa LPAREN r RPAREN
kinetic law: MODEL1310110045#
reactant: MODEL1310110045#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 0 AUTHORS: PMID: 17173541 NOTES:added during gap-filling, no evidence for such a reaction. only assumed.
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: demand reaction for pmtcoa
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110045#_77d05828_bae8_4294_a014_dc3d5b93c64a
is: SBO:0000252
boundary condition: true
constant: false
name: ALG6
initial amount: NaN
is encoded by: hsa:29929
has only substance units: false
initial concentration: NaN
is: Q9Y672
type: Species

metaR FAOXC101C102m
kinetic law: MODEL1310110045#
product: MODEL1310110045#
reactant: MODEL1310110045#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C10:1-->C10:2)m
type: Reaction

metaR r0086
name: 2-Oxoglutaramate amidohydrolase Glutamate metabolism EC:3.5.1.3
notes: GENE_ASSOCIATION: (56954.1) SUBSYSTEM: Urea cycle EC Number: 3.5.1.3 Confidence Level: 0 AUTHORS: PMID:3003502,PMID:319948,PMID:4436326,PMID:5114531,PMID:894284 NOTES:
kinetic law: MODEL1310110045#
is version of: http://identifiers.org/ec-code/3.5.1.3
modifier: MODEL1310110045#
product: MODEL1310110045#
reversible: false
fast: false
is: SBO:0000176
type: Reaction
reactant: MODEL1310110045#
is described by: ECO:0000000

metaR G6PDH1rer
modifier: MODEL1310110045#
fast: false
product: MODEL1310110045#
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (9563.1) SUBSYSTEM: Pentose phosphate pathway EC Number: 1.1.1.47 Confidence Level: 4 AUTHORS: PMID:10349511,PMID:12831846,PMID:2156506 NOTES:tv, jp NCD
name: glucose-6-phosphate dehydrogenase, endoplasmic reticulum
reversible: true
type: Reaction
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.1.1.47
reactant: MODEL1310110045#
kinetic law: MODEL1310110045#

http://identifiers.org/biomodels.db/MODEL1310110045#_37e5b933_0d9f_4119_9944_d249ea580c08
name: _BE966236_1_c
is: SBO:0000252
is encoded by: hsa:BE966236
initial concentration: NaN
boundary condition: true
has only substance units: false
constant: false
type: Species
initial amount: NaN

metaR CYSSNAT5tc
kinetic law: MODEL1310110045#
product: MODEL1310110045#
reactant: MODEL1310110045#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: transport of L-Cysteine into the cell coupled with co-transport with Sodium and counter transport with proton by SNAT5 transporter.
type: Reaction

metaR CHOLtu
reversible: true
kinetic law: MODEL1310110045#
is: SBO:0000185
reactant: MODEL1310110045#
type: Reaction
is described by: ECO:0000269
modifier: MODEL1310110045#
product: MODEL1310110045#
fast: false
name: Choline uniport
notes: GENE_ASSOCIATION: (6582.1) or (6584.1) or (6582.2) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12883891 NOTES:SAB electrogenic, Na indepdendent & rev

metaM s2l2fn2m2masn e
boundary condition: false
name: PA6
initial concentration: 1.0
is: HMDB00244
type: Species
constant: false
is: SBO:0000247
has only substance units: false
is: C00255
initial amount: NaN
is: CHEBI:3554
notes: FORMULA: C90H145N6O65X CHARGE: -2

metaM ksii core2 pre1 g
name: keratan sulfate II biosynthesis, precursor 1
notes: FORMULA: C33H53N3O23X CHARGE: -1
type: Species
is: SBO:0000247
is: CHEBI:28067
initial amount: NaN
initial concentration: 1.0
constant: false
has only substance units: false
boundary condition: false

metaR RE0926E
fast: false
modifier: MODEL1310110045#
reversible: true
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.2.1.17
is version of: http://identifiers.org/ec-code/3.2.1.1
reactant: MODEL1310110045#
kinetic law: MODEL1310110045#
product: MODEL1310110045#
type: Reaction
name: RE0926
notes: GENE_ASSOCIATION: (276.1) or (277.1) or (278.1) or (279.1) or (276.1) or (277.1) or (278.1) or (279.1) or (280.1) or (84569.1) SUBSYSTEM: Starch and sucrose metabolism EC Number: 3.2.1.1 Confidence Level: 0 AUTHORS: PMID:385176,PMID:8528071,PMID:890964 NOTES:
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110045#_9e2f1c8b_5133_44b0_826d_3c000b3ea77a
constant: false
is: SBO:0000252
name: SLC7A8
boundary condition: true
has only substance units: false
initial concentration: NaN
type: Species
is: Q9UHI5
initial amount: NaN
is encoded by: hsa:23428

metaR r2411
name: Mitochondrial Carrier (MC) TCDB:2.A.29.19.1
type: Reaction
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172 NOTES:
product: MODEL1310110045#
kinetic law: MODEL1310110045#
is described by: ECO:0000000
reactant: MODEL1310110045#
is: SBO:0000185
reversible: false

metaM gdp g
initial amount: NaN
has only substance units: false
is: CHEBI:58189
boundary condition: false
type: Species
notes: FORMULA: C10H12N5O11P2 CHARGE: -3 INCHI: InChI=1S/C10H15N5O11P2/c11-10-13-7-4(8(18)14-10)12-2-15(7)9-6(17)5(16)3(25-9)1-24-28(22,23)26-27(19,20)21/h2-3,5-6,9,16-17H,1H2,(H,22,23)(H2,19,20,21)(H3,11,13,14,18)/p-3/t3-,5-,6-,9-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00043 EHMN_ABBREVIATION: C00035
name: GDP(3-)
initial concentration: 1.0
is: HMDB01201
constant: false
is: SBO:0000247

metaR r1660
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
type: Reaction
reversible: true
modifier: MODEL1310110045#
is described by: ECO:0000000
reactant: MODEL1310110045#
fast: false
product: MODEL1310110045#
kinetic law: MODEL1310110045#
is: SBO:0000185

metaR EX gua LPAREN e RPAREN
kinetic law: MODEL1310110045#
reactant: MODEL1310110045#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Guanine exchange
type: Reaction

metaM crn e
initial concentration: 1.0
boundary condition: false
is: C00318
is: CHEBI:16347
is: SBO:0000247
has only substance units: false
constant: false
is: HMDB00062
initial amount: NaN
notes: FORMULA: C7H15NO3 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00270 EHMN_ABBREVIATION: C00318
type: Species
name: L-Carnitine

http://identifiers.org/biomodels.db/MODEL1310110045#_5e62e129_36f8_45dd_8f64_03c6b999ab7f
boundary condition: true
has only substance units: false
initial amount: NaN
constant: false
initial concentration: NaN
name: SLC12A6
is: Q9UHW9
is encoded by: hsa:9990
type: Species
is: SBO:0000252

metaR DIDPtn
is described by: ECO:0000000
product: MODEL1310110045#
reversible: true
name: dIDP nuclear transport
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: NOTES:NCD
kinetic law: MODEL1310110045#
reactant: MODEL1310110045#
is: SBO:0000185
type: Reaction

metaR ACHtn
reactant: MODEL1310110045#
is: SBO:0000185
product: MODEL1310110045#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 1 AUTHORS: NOTES:it
kinetic law: MODEL1310110045#
name: Acetylcholin transport, nuclear trhough pores
reversible: true
fast: false
type: Reaction
is described by: ECO:0000000

metaM prist c
boundary condition: false
initial amount: NaN
type: Species
name: pristanic acid
initial concentration: 1.0
is: HMDB00795
constant: false
has only substance units: false
notes: FORMULA: C19H37O2 CHARGE: -1 INCHI: InChI=1S/C19H38O2/c1-15(2)9-6-10-16(3)11-7-12-17(4)13-8-14-18(5)19(20)21/h15-18H,6-14H2,1-5H3,(H,20,21)
is: CHEBI:51340
is: SBO:0000247

metaM prostgd2 e
is: CHEBI:57406
constant: false
boundary condition: false
initial concentration: 1.0
name: prostaglandin D2(1-)
notes: FORMULA: C20H31O5 CHARGE: -1 INCHI: InChI=1S/C20H32O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h4,7,12-13,15-18,21-22H,2-3,5-6,8-11,14H2,1H3,(H,24,25)/p-1/b7-4-,13-12+/t15-,16+,17+,18-/m0/s1 EHMN_ABBREVIATION: C00696
initial amount: NaN
is: SBO:0000247
type: Species
is: HMDB01403
has only substance units: false

metaR GLYCtm
product: MODEL1310110045#
is: SBO:0000185
is described by: ECO:0000000
reactant: MODEL1310110045#
name: glycerol transport
kinetic law: MODEL1310110045#
reversible: true
fast: false
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: NOTES:TDV

http://identifiers.org/biomodels.db/MODEL1310110045#_fb6d6add_bb2f_4bbd_b77c_d8af8d943e57
type: Species
is: B3KRT1
initial amount: NaN
is: SBO:0000252
name: ISYNA1
is encoded by: hsa:51477
initial concentration: NaN
constant: false
has only substance units: false
boundary condition: true

metaM ach n
boundary condition: false
is: CHEBI:15355
notes: FORMULA: C7H16NO2 CHARGE: 1 INCHI: InChI=1S/C7H16NO2/c1-7(9)10-6-5-8(2,3)4/h5-6H2,1-4H3/q+1 HEPATONET_1.0_ABBREVIATION: HC00877 EHMN_ABBREVIATION: C01996
has only substance units: false
type: Species
constant: false
initial amount: NaN
initial concentration: 1.0
is: HMDB00895
is: SBO:0000247
name: acetylcholine

metaM gdp e
initial amount: NaN
name: GDP(3-)
initial concentration: 1.0
is: SBO:0000247
is: CHEBI:58189
constant: false
has only substance units: false
is: HMDB01201
notes: FORMULA: C10H12N5O11P2 CHARGE: -3 INCHI: InChI=1S/C10H15N5O11P2/c11-10-13-7-4(8(18)14-10)12-2-15(7)9-6(17)5(16)3(25-9)1-24-28(22,23)26-27(19,20)21/h2-3,5-6,9,16-17H,1H2,(H,22,23)(H2,19,20,21)(H3,11,13,14,18)/p-3/t3-,5-,6-,9-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00043 EHMN_ABBREVIATION: C00035
type: Species
boundary condition: false

metaR r2079
reactant: MODEL1310110045#
fast: false
modifier: MODEL1310110045#
product: MODEL1310110045#
kinetic law: MODEL1310110045#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
reversible: true
is: SBO:0000185
type: Reaction
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110045#_d5f9b4ee_b0ce_4aa4_a584_a52220b52840
initial amount: NaN
has only substance units: false
is: Q9Y5B8
type: Species
is encoded by: hsa:29922
initial concentration: NaN
is: SBO:0000252
name: NME7
boundary condition: true
constant: false

metaR r1662
type: Reaction
fast: false
modifier: MODEL1310110045#
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
product: MODEL1310110045#
is described by: ECO:0000000
reactant: MODEL1310110045#
is: SBO:0000185
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reversible: true
kinetic law: MODEL1310110045#

metaM xol7ah c
notes: FORMULA: C27H46O2 CHARGE: 0 INCHI: InChI=1S/C27H46O2/c1-17(2)7-6-8-18(3)21-9-10-22-25-23(12-14-27(21,22)5)26(4)13-11-20(28)15-19(26)16-24(25)29/h17-19,21-25,29H,6-16H2,1-5H3/t18-,19+,21-,22+,23+,24-,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01460 EHMN_ABBREVIATION: C05451
name: 7alpha-hydroxy-5beta-cholestan-3-one
boundary condition: false
type: Species
initial concentration: 1.0
is: SBO:0000247
is: HMDB06892
constant: false
is: CHEBI:2290
initial amount: NaN
has only substance units: false

metaM 3mox4hpac m
type: Species
boundary condition: false
is: SBO:0000247
notes: FORMULA: C9H10O3 CHARGE: 0 INCHI: InChI=1S/C9H10O3/c1-12-9-6-7(4-5-10)2-3-8(9)11/h2-3,5-6,11H,4H2,1H3 HEPATONET_1.0_ABBREVIATION: HC01518 EHMN_ABBREVIATION: C05581
initial concentration: 1.0
is: HMDB05175
name: (4-hydroxy-3-methoxyphenyl)acetaldehyde
has only substance units: false
initial amount: NaN
constant: false
is: CHEBI:28111

metaM crn c
has only substance units: false
is: C00318
is: CHEBI:16347
is: SBO:0000247
notes: FORMULA: C7H15NO3 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00270 EHMN_ABBREVIATION: C00318
is: HMDB00062
constant: false
initial amount: NaN
type: Species
initial concentration: 1.0
name: L-Carnitine
boundary condition: false

metaM dopa c
is: CHEBI:59905
has only substance units: false
type: Species
name: dopaminium(1+)
initial concentration: 1.0
is: HMDB00073
constant: false
notes: FORMULA: C8H12NO2 CHARGE: 1 INCHI: InChI=1S/C8H11NO2/c9-4-3-6-1-2-7(10)8(11)5-6/h1-2,5,10-11H,3-4,9H2/p+1 HEPATONET_1.0_ABBREVIATION: HC01175 EHMN_ABBREVIATION: C03758
is: SBO:0000247
boundary condition: false
initial amount: NaN

metaR MI145PP
reactant: MODEL1310110045#
is version of: http://identifiers.org/ec-code/3.1.3.56
notes: GENE_ASSOCIATION: (3635.1) or (8867.2) or (3636.1) or (27124.2) or (8867.1) or (27124.1) or (3633.1) or (56623.1) or (3632.1) SUBSYSTEM: Inositol phosphate metabolism EC Number: 3.1.3.56 Confidence Level: 4 AUTHORS: PMID:10593988,PMID:10764818,PMID:15261714,PMID:2906139,PMID:7721860,PMID:8006039,PMID:8013665,PMID:8530088,PMID:8769125,PMID:9428629,PMID:9824312 NOTES:NCD
type: Reaction
reversible: false
is version of: http://identifiers.org/ec-code/3.1.3.36
is described by: ECO:0000269
product: MODEL1310110045#
fast: false
name: inositol-1,4,5-trisphosphate 5-phosphatase
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.1.3.86
modifier: MODEL1310110045#
kinetic law: MODEL1310110045#

http://identifiers.org/biomodels.db/MODEL1310110045#_66843242_ee42_4774_9ff9_04ec365840d7
initial concentration: NaN
is: O15382
has only substance units: false
constant: false
is encoded by: hsa:587
is: SBO:0000252
name: BCAT2
boundary condition: true
type: Species
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110045#_4ed16fc8_cf43_4eaf_9a09_47750abd0372
is: P11166
is encoded by: hsa:6513
name: SLC2A1
has only substance units: false
type: Species
boundary condition: true
constant: false
initial concentration: NaN
is: SBO:0000252
initial amount: NaN

metaR ALAR
fast: false
product: MODEL1310110045#
notes: GENE_ASSOCIATION: (11212.1) SUBSYSTEM: Alanine and aspartate metabolism EC Number: 5.1.1.1 Confidence Level: 1 AUTHORS: NOTES:
reactant: MODEL1310110045#
name: alanine racemase
modifier: MODEL1310110045#
kinetic law: MODEL1310110045#
is described by: ECO:0000212
reversible: true
type: Reaction
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110045#_c243f191_78e5_46db_a27d_88de74f4fc6f
type: Species
is: SBO:0000252
name: OXSM
initial concentration: NaN
initial amount: NaN
has only substance units: false
boundary condition: true
constant: false
is: Q9NWU1
is encoded by: hsa:54995

metaR EX dttp LPAREN e RPAREN
kinetic law: MODEL1310110045#
reactant: MODEL1310110045#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of dTTP(4-)
type: Reaction

metaR r1661
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
product: MODEL1310110045#
reactant: MODEL1310110045#
reversible: true
type: Reaction
is: SBO:0000185
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
modifier: MODEL1310110045#
kinetic law: MODEL1310110045#
is described by: ECO:0000000
fast: false

metaM cholp c
initial concentration: 1.0
has only substance units: false
boundary condition: false
notes: FORMULA: C5H13NO4P CHARGE: -1 INCHI: InChI=1S/C5H14NO4P/c1-6(2,3)4-5-10-11(7,8)9/h4-5H2,1-3H3,(H-,7,8,9)/p-1 HEPATONET_1.0_ABBREVIATION: HC00442 EHMN_ABBREVIATION: C00588
name: choline phosphate(1-)
is: SBO:0000247
is: CHEBI:295975
initial amount: NaN
type: Species
constant: false

metaR CORE3GTg
fast: false
reversible: false
is: SBO:0000176
product: MODEL1310110045#
notes: GENE_ASSOCIATION: (192134.1) SUBSYSTEM: O-glycan synthesis EC Number: 2.4.1.147 Confidence Level: 0 AUTHORS: PMID:11821425 NOTES:NCD
modifier: MODEL1310110045#
kinetic law: MODEL1310110045#
type: Reaction
reactant: MODEL1310110045#
name: Core 3 beta-GlcNAc-transferase, Golgi apparatus
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/2.4.1.149

http://identifiers.org/biomodels.db/MODEL1310110045#_35da11ef_e363_447c_aa2f_db7472dace87
is encoded by: hsa:56953
name: NT5M
boundary condition: true
initial concentration: NaN
type: Species
initial amount: NaN
has only substance units: false
is: Q9NPB1
constant: false
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110045#_48db730e_c64e_41fa_bc2e_7ce99ba3563c
constant: false
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:51557
initial amount: NaN
type: Species
boundary condition: true
is: Q5TDP6
has only substance units: false
name: LGSN

metaR EX ser L LPAREN e RPAREN
kinetic law: MODEL1310110045#
reactant: MODEL1310110045#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for L-serine
type: Reaction

metaR ALOX5
reactant: MODEL1310110045#
modifier: MODEL1310110045#
fast: false
type: Reaction
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (240.1) SUBSYSTEM: Eicosanoid metabolism EC Number: 1.13.11.34 Confidence Level: 4 AUTHORS: PMID:2829172 NOTES:cofactors + usage still not clear see version ALOX5b for ATP concomittant hydrolysis - literature notes in vitro requirement for Ca and ATP for activity in addition to Fe
kinetic law: MODEL1310110045#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.13.11.34
reversible: false
name: Arachidonate 5-lipoxygenase
product: MODEL1310110045#

metaR ITCOALm
kinetic law: MODEL1310110045#
fast: false
type: Reaction
notes: GENE_ASSOCIATION: (8802.1 and 8803.1) SUBSYSTEM: C5-branched dibasic acid metabolism EC Number: 6.2.1.5 Confidence Level: 1 AUTHORS: PMID:13783048 NOTES:NCD
product: MODEL1310110045#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/6.2.1.5
reversible: true
reactant: MODEL1310110045#
is version of: http://identifiers.org/ec-code/6.2.1.4
modifier: MODEL1310110045#
is described by: ECO:0000212
name: Itaconate--CoA ligase (ADP-forming), mitochondrial

metaM gly m
is: CHEBI:15428
is: SBO:0000247
constant: false
initial amount: NaN
has only substance units: false
initial concentration: 1.0
is: C00037
boundary condition: false
is: HMDB00123
notes: FORMULA: C2H5NO2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00045 EHMN_ABBREVIATION: C00037
type: Species
name: Glycine

metaM dopa e
boundary condition: false
has only substance units: false
constant: false
is: HMDB00073
notes: FORMULA: C8H12NO2 CHARGE: 1 INCHI: InChI=1S/C8H11NO2/c9-4-3-6-1-2-7(10)8(11)5-6/h1-2,5,10-11H,3-4,9H2/p+1 HEPATONET_1.0_ABBREVIATION: HC01175 EHMN_ABBREVIATION: C03758
name: dopaminium(1+)
initial concentration: 1.0
is: SBO:0000247
initial amount: NaN
is: CHEBI:59905
type: Species

http://identifiers.org/biomodels.db/MODEL1310110045#_b1b326bb_0573_4a87_b798_4848d9cf54f7
has only substance units: false
boundary condition: true
is encoded by: hsa:278
initial amount: NaN
type: Species
is: SBO:0000252
name: AMY1C
is: P04745
initial concentration: NaN
constant: false

metaR G14T13g
type: Reaction
reactant: MODEL1310110045#
fast: false
name: beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase, Golgi
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/2.4.1.38
is version of: http://identifiers.org/ec-code/2.4.1.22
is: SBO:0000176
kinetic law: MODEL1310110045#
product: MODEL1310110045#
modifier: MODEL1310110045#
notes: GENE_ASSOCIATION: (8703.1) or (2683.1) or (8704.2) or (8704.1) or (9334.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.38 Confidence Level: 4 AUTHORS: PMID:12512857,PMID:1903938,PMID:3094506,PMID:3144273,PMID:9405390,PMID:9435216 NOTES:Keratan sulfate I biosynthesis NCD
is version of: http://identifiers.org/ec-code/2.4.1.90
reversible: false

metaR r0295
reversible: false
name: glycine synthase Nitrogen metabolism EC:2.1.2.10
fast: false
product: MODEL1310110045#
notes: GENE_ASSOCIATION: (6576.1) SUBSYSTEM: Glycine, serine, alanine and threonine metabolism EC Number: 2.1.2.10 Confidence Level: 0 AUTHORS: PMID:7916605 NOTES:
is: SBO:0000176
is described by: ECO:0000000
modifier: MODEL1310110045#
kinetic law: MODEL1310110045#
reactant: MODEL1310110045#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110045#_1c591db5_f7b0_4920_a9c2_d48246c4ec6f
is: SBO:0000252
constant: false
initial amount: NaN
initial concentration: NaN
is: Q9Y6T7
type: Species
is encoded by: hsa:1607
has only substance units: false
name: DGKB
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110045#_ff65ed51_de54_46ee_809a_476803ba2508
is: P00352
initial amount: NaN
boundary condition: true
initial concentration: NaN
has only substance units: false
name: ALDH1A1
is encoded by: hsa:216
constant: false
type: Species
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110045#_0520c94f_054b_44a5_9baa_c00e07d3d52d
is: SBO:0000252
constant: false
name: SLC24A4
boundary condition: true
has only substance units: false
type: Species
is encoded by: hsa:123041
initial concentration: NaN
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110045#_9f180503_9c55_408a_bbe8_5332d967d5a9
has only substance units: false
is: SBO:0000252
initial amount: NaN
type: Species
constant: false
initial concentration: NaN
is encoded by: hsa:2720
boundary condition: true
name: GLB1
is: P16278

metaM nrpphr e
constant: false
initial amount: NaN
initial concentration: 1.0
name: Norepinephrine
is: HMDB00216
notes: FORMULA: C8H12NO3 CHARGE: 1 INCHI: InChI=1S/C8H11NO3/c9-4-8(12)5-1-2-6(10)7(11)3-5/h1-3,8,10-12H,4,9H2 HEPATONET_1.0_ABBREVIATION: HC00426 EHMN_ABBREVIATION: C00547
type: Species
is: SBO:0000247
has only substance units: false
boundary condition: false
is: CHEBI:33569

http://identifiers.org/biomodels.db/MODEL1310110045#_2f924317_5101_48bc_8e7c_553648ac5fad
name: LDHC
boundary condition: true
has only substance units: false
constant: false
initial concentration: NaN
is: P07864
is: SBO:0000252
type: Species
initial amount: NaN
is encoded by: hsa:3948

metaM s2l2fn2m2masn g
type: Species
constant: false
name: PA6
boundary condition: false
is: HMDB00868
initial concentration: 1.0
is: SBO:0000247
initial amount: NaN
is: CHEBI:57737
has only substance units: false
notes: FORMULA: C90H145N6O65X CHARGE: -2

metaR r0908
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:3988731,PMID:6706970,PMID:7050120 NOTES:
kinetic law: MODEL1310110045#
product: MODEL1310110045#
type: Reaction
fast: false
name: Postulated transport reaction
reactant: MODEL1310110045#
is: SBO:0000185
reversible: true
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110045#_e5a7f2de_c6d9_48a7_9d8b_674e1f3c8fcc
has only substance units: false
initial amount: NaN
is encoded by: hsa:6508
boundary condition: true
constant: false
name: SLC4A3
is: SBO:0000252
type: Species
initial concentration: NaN

metaM 1pyr5c c
name: 1-Pyrroline-5-carboxylate
is: CHEBI:15893
is: HMDB01301
is: C03912
notes: FORMULA: C5H6NO2 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC01199 EHMN_ABBREVIATION: C03912
type: Species
is: SBO:0000247
constant: false
initial amount: NaN
has only substance units: false
boundary condition: false
initial concentration: 1.0

metaR RBFK
modifier: MODEL1310110045#
fast: false
reversible: false
reactant: MODEL1310110045#
kinetic law: MODEL1310110045#
name: riboflavin kinase
notes: GENE_ASSOCIATION: (55312.1) SUBSYSTEM: Vitamin B2 metabolism EC Number: Confidence Level: 4 AUTHORS: NOTES:
type: Reaction
product: MODEL1310110045#
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/2.7.1.26
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110045#_d79c8e9c_2004_4f30_bc9f_8c55078fe648
boundary condition: true
type: Species
is: SBO:0000252
constant: false
is encoded by: hsa:6391
name: SDHC
initial amount: NaN
is: Q99643
initial concentration: NaN
has only substance units: false

metaM tchola x
is: SBO:0000247
type: Species
initial concentration: 1.0
initial amount: NaN
boundary condition: false
constant: false
notes: FORMULA: C26H45NO7S CHARGE: 0 INCHI: InChI=1S/C26H45NO7S/c1-15(4-7-23(31)27-10-11-35(32,33)34)18-5-6-19-24-20(14-22(30)26(18,19)3)25(2)9-8-17(28)12-16(25)13-21(24)29/h15-22,24,28-30H,4-14H2,1-3H3,(H,27,31)(H,32,33,34)/p-1/t15-,16+,17-,18-,19+,20+,21-,22+,24+,25+,26-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01378 EHMN_ABBREVIATION: C05122
is: CHEBI:36257
is: HMDB00036
name: taurocholate
has only substance units: false

metaR LEUKTRA4t
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: 1.1.1.27 Confidence Level: 2 AUTHORS: PMID:15987839,PMID:9927705 NOTES:
product: MODEL1310110045#
reversible: true
kinetic law: MODEL1310110045#
is described by: ECO:0000269
fast: false
name: leukotriene A4 transport
is: SBO:0000185
reactant: MODEL1310110045#
type: Reaction

metaM cs c l
initial amount: NaN
is: HMDB02183
boundary condition: false
type: Species
is: CHEBI:36005
name: chondroitin sulfate C (GalNAc6S-GlcA), free chain
has only substance units: false
constant: false
initial concentration: 1.0
notes: FORMULA: C45H67N2O46S3 CHARGE: -5
is: SBO:0000247

metaM HC01522 c
name: Gentisate aldehyde
boundary condition: false
constant: false
initial amount: NaN
has only substance units: false
is: SBO:0000247
type: Species
notes: FORMULA: C7H6O3 CHARGE: 0 INCHI: InChI=1S/C7H6O3/c8-4-5-3-6(9)1-2-7(5)10/h1-4,9-10H EHMN_ABBREVIATION: C05585
initial concentration: 1.0
is: CHEBI:28508

metaR r0909
is described by: ECO:0000000
name: Transport reaction
fast: false
reversible: true
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:3988731,PMID:6706970,PMID:7050120 NOTES:
reactant: MODEL1310110045#
is: SBO:0000185
kinetic law: MODEL1310110045#
product: MODEL1310110045#

http://identifiers.org/biomodels.db/MODEL1310110045#_b15367c7_9773_4ac4_b541_1e88959d2541
is: Q5SPY7
is: SBO:0000252
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:954
name: ENTPD2
type: Species
has only substance units: false
constant: false
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110045#_9f24fabc_1700_46fe_8c8a_b27a34cc5757
has only substance units: false
name: IVD
is encoded by: hsa:3712
initial concentration: NaN
is: B3KVI7
boundary condition: true
type: Species
constant: false
initial amount: NaN
is: SBO:0000252

metaR RE2660C
kinetic law: MODEL1310110045#
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Tetrahydrobiopterin metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:9647871 NOTES:
type: Reaction
reactant: MODEL1310110045#
product: MODEL1310110045#
name: RE2660
reversible: true
fast: false
is described by: ECO:0000000

metaM mmcoa R m
notes: FORMULA: C25H35N7O19P3S CHARGE: -5 INCHI: InChI=1S/C25H40N7O19P3S/c1-12(23(37)38)24(39)55-7-6-27-14(33)4-5-28-21(36)18(35)25(2,3)9-48-54(45,46)51-53(43,44)47-8-13-17(50-52(40,41)42)16(34)22(49-13)32-11-31-15-19(26)29-10-30-20(15)32/h10-13,16-18,22,34-35H,4-9H2,1-3H3,(H,27,33)(H,28,36)(H,37,38)(H,43,44)(H,45,46)(H2,26,29,30)(H2,40,41,42)/p-5/t12-,13-,16-,17-,18+,22-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00721
boundary condition: false
type: Species
is: CHEBI:57326
initial concentration: 1.0
initial amount: NaN
name: (R)-methylmalonyl-CoA(5-)
is: HMDB01269
has only substance units: false
is: SBO:0000247
constant: false

metaM dgsn c
initial amount: NaN
initial concentration: 1.0
type: Species
has only substance units: false
name: Deoxyguanosine
boundary condition: false
is: SBO:0000247
is: HMDB00085
is: CHEBI:17172
is: C00330
notes: FORMULA: C10H13N5O4 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00280 EHMN_ABBREVIATION: C00330
constant: false

metaM nrpphr c
boundary condition: false
initial concentration: 1.0
is: HMDB00216
type: Species
initial amount: NaN
is: SBO:0000247
name: Norepinephrine
constant: false
notes: FORMULA: C8H12NO3 CHARGE: 1 INCHI: InChI=1S/C8H11NO3/c9-4-8(12)5-1-2-6(10)7(11)3-5/h1-3,8,10-12H,4,9H2 HEPATONET_1.0_ABBREVIATION: HC00426 EHMN_ABBREVIATION: C00547
has only substance units: false
is: CHEBI:33569

metaR RE1523M
notes: GENE_ASSOCIATION: (1892.1) or (3030.1) or (1962.1) or (3032.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.17 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:7923814,PMID:9568246,PMID:9920399 NOTES:
is: SBO:0000176
is described by: ECO:0000000
reactant: MODEL1310110045#
reversible: true
type: Reaction
is version of: http://identifiers.org/ec-code/2.3.1.16
is version of: http://identifiers.org/ec-code/4.2.1.17
is version of: http://identifiers.org/ec-code/1.1.1.35
modifier: MODEL1310110045#
name: RE1523
product: MODEL1310110045#
kinetic law: MODEL1310110045#
fast: false

metaM val L c
boundary condition: false
has only substance units: false
constant: false
initial concentration: 1.0
type: Species
initial amount: NaN
is: SBO:0000247
name: L-valine
is: HMDB00883
notes: FORMULA: C5H11NO2 CHARGE: 0 INCHI: InChI=1S/C5H11NO2/c1-3(2)4(6)5(7)8/h3-4H,6H2,1-2H3,(H,7,8)/t4-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00174
is: CHEBI:16414

http://identifiers.org/biomodels.db/MODEL1310110045#_622b6d07_7fb5_43b7_b4b2_95ee4d0aa6d6
has only substance units: false
initial concentration: NaN
boundary condition: true
name: _AA629629_1_m
constant: false
is encoded by: hsa:AA629629
is: SBO:0000252
type: Species
initial amount: NaN

metaR EX gal LPAREN e RPAREN
kinetic law: MODEL1310110045#
reactant: MODEL1310110045#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for D-Galactose
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110045#_0e181b88_aa9e_4117_8ce5_f42e5eb2af19
boundary condition: true
is encoded by: hsa:8525
is: SBO:0000252
initial concentration: NaN
constant: false
has only substance units: false
initial amount: NaN
name: DGKZ
is: B7Z2M9
type: Species

metaR ACOAD9m
reactant: MODEL1310110045#
is version of: http://identifiers.org/ec-code/1.3.99.3
reversible: false
is described by: ECO:0000269
type: Reaction
name: acyl-CoA dehydrogenase (isobutyryl-CoA), mitochondrial
notes: GENE_ASSOCIATION: (34.1) or (27034.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 1.3.99.12 Confidence Level: 4 AUTHORS: PMID:11013134 NOTES:MM
kinetic law: MODEL1310110045#
modifier: MODEL1310110045#
is: SBO:0000176
product: MODEL1310110045#
fast: false

metaR EX retinol LPAREN e RPAREN
kinetic law: MODEL1310110045#
reactant: MODEL1310110045#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Retinol exchange
type: Reaction

metaR HMGLm
fast: false
is described by: ECO:0000134
product: MODEL1310110045#
reversible: false
is version of: http://identifiers.org/ec-code/4.1.3.4
reactant: MODEL1310110045#
is: SBO:0000176
name: hydroxymethylglutaryl-CoA lyase
type: Reaction
kinetic law: MODEL1310110045#
notes: GENE_ASSOCIATION: (3155.1) or (54511.1) SUBSYSTEM: Cholesterol metabolism EC Number: 4.1.3.4 Confidence Level: 4 AUTHORS: PMID:11129331 NOTES:TV
modifier: MODEL1310110045#

http://identifiers.org/biomodels.db/MODEL1310110045#_57c71d00_dd61_444b_a2d6_133d2cc6be11
is encoded by: hsa:7371
is: Q9BZX2
constant: false
is: SBO:0000252
initial concentration: NaN
type: Species
name: UCK2
initial amount: NaN
has only substance units: false
boundary condition: true

metaM thbpt4acam c
initial concentration: 1.0
type: Species
notes: FORMULA: C9H15N5O4 CHARGE: 0 INCHI: InChI=1S/C9H15N5O4/c1-3(15)5(16)4-2-11-6-9(18,14-4)7(17)13-8(10)12-6/h3-5,14-16,18H,2H2,1H3,(H3,10,11,12,13,17) EHMN_ABBREVIATION: CE1951
is: HMDB02281
is: CHEBI:15374
constant: false
name: 4a-hydroxytetrahydrobiopterin
has only substance units: false
boundary condition: false
initial amount: NaN
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110045#_13c1d94b_a008_4ea6_ab70_f372be41eadc
is: P52824
boundary condition: true
is: SBO:0000252
type: Species
name: DGKQ
is encoded by: hsa:1609
constant: false
initial concentration: NaN
initial amount: NaN
has only substance units: false

metaR S2L2N2M2MASNtly
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD
name: s2l2n2m2masn transport, extracellular to lysosome
fast: false
is: SBO:0000185
reactant: MODEL1310110045#
kinetic law: MODEL1310110045#
is described by: ECO:0000000
reversible: false
type: Reaction
product: MODEL1310110045#

metaM s2l2fn2m2masn l
boundary condition: false
name: PA6
is: HMDB00174
is: CHEBI:18287
type: Species
has only substance units: false
notes: FORMULA: C90H145N6O65X CHARGE: -2
initial amount: NaN
constant: false
is: SBO:0000247
initial concentration: 1.0

metaR DCSPTN1t
is: SBO:0000185
reversible: true
kinetic law: MODEL1310110045#
type: Reaction
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11788354,PMID:12864740 NOTES:NJ
reactant: MODEL1310110045#
name: fatty acid transport via diffusion
fast: false
product: MODEL1310110045#

http://identifiers.org/biomodels.db/MODEL1310110045#_13843576_b8cf_4013_b7fe_de717cbc786f
constant: false
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:1607
initial concentration: NaN
name: DGKB
type: Species
boundary condition: true
has only substance units: false

metaM i e
type: Species
notes: FORMULA: I CHARGE: -1 INCHI: InChI=1S/HI/h1H/p-1 EHMN_ABBREVIATION: C00708
initial amount: NaN
is: SBO:0000247
boundary condition: false
initial concentration: 1.0
is: CHEBI:16382
constant: false
is: HMDB12238
name: iodide
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110045#_ff54e69e_9925_4102_8528_5a138e5439ea
has only substance units: false
is encoded by: hsa:T83654
initial amount: NaN
initial concentration: NaN
boundary condition: true
is: SBO:0000252
constant: false
type: Species
name: _T83654_1_e

metaM gly x
initial amount: NaN
boundary condition: false
type: Species
notes: FORMULA: C2H5NO2 CHARGE: 0 INCHI: InChI=1S/C2H5NO2/c3-1-2(4)5/h1,3H2,(H,4,5) HEPATONET_1.0_ABBREVIATION: HC00045 EHMN_ABBREVIATION: C00037
is: SBO:0000247
name: glycine
has only substance units: false
is: HMDB00123
is: CHEBI:15428
initial concentration: 1.0
constant: false

metaR r2405
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172 NOTES:
name: Mitochondrial Carrier (MC) TCDB:2.A.29.19.1
fast: false
is: SBO:0000185
reversible: false
type: Reaction
is described by: ECO:0000000
product: MODEL1310110045#
reactant: MODEL1310110045#
kinetic law: MODEL1310110045#

http://identifiers.org/biomodels.db/MODEL1310110045#_b550da6a_4231_4f9f_adb8_2645bf7e1511
is: P27707
initial amount: NaN
is: SBO:0000252
boundary condition: true
constant: false
type: Species
initial concentration: NaN
is encoded by: hsa:1633
name: DCK
has only substance units: false

metaR 5MTHFt2le
reversible: true
is: SBO:0000185
product: MODEL1310110045#
fast: false
reactant: MODEL1310110045#
type: Reaction
name: 5-methyltetrahydrofolate transport via anion exchange
kinetic law: MODEL1310110045#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134

metaM 44mctr r
initial amount: NaN
type: Species
is: SBO:0000247
constant: false
has only substance units: false
is: CHEBI:17813
notes: FORMULA: C29H46O CHARGE: 0 INCHI: InChI=1S/C29H46O/c1-19(2)9-8-10-20(3)22-12-13-23-21-11-14-25-27(4,5)26(30)16-18-29(25,7)24(21)15-17-28(22,23)6/h9,13,20,22,25-26,30H,8,10-12,14-18H2,1-7H3/t20-,22-,25+,26+,28-,29-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01808 EHMN_ABBREVIATION: C11455
is: HMDB01023
initial concentration: 1.0
name: 4,4-dimethyl-5alpha-cholesta-8,14,24-trien-3beta-ol
boundary condition: false

metaR PTE3x
type: Reaction
is described by: ECO:0000000
fast: false
is: SBO:0000176
reversible: false
notes: GENE_ASSOCIATION: (10965.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: PMID:10944470 NOTES:NJ
reactant: MODEL1310110045#
is version of: http://identifiers.org/ec-code/3.1.2.2
kinetic law: MODEL1310110045#
name: peroxisomal acyl-CoA thioesterase
modifier: MODEL1310110045#
product: MODEL1310110045#

metaM m7masnB r
boundary condition: false
name: (alpha-D-mannosyl)7-beta-D-mannosyl-diacetylchitobiosyl-L-asparagine, isoform B (protein)
constant: false
type: Species
notes: FORMULA: C64H107N2O50X CHARGE: 0
has only substance units: false
is: SBO:0000247
initial concentration: 1.0
initial amount: NaN
is: C05881

metaM tre e
is: SBO:0000247
is: CHEBI:16551
constant: false
has only substance units: false
initial concentration: 1.0
name: Trehalose
type: Species
is: HMDB00975
is: C01083
initial amount: NaN
boundary condition: false
notes: FORMULA: C12H22O11 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00658 EHMN_ABBREVIATION: C01083

metaR EX n2m2nmasn LPAREN e RPAREN
kinetic law: MODEL1310110045#
reactant: MODEL1310110045#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: N-Acetyl-beta-D-glucosaminyl-1,2-alpha-D-mannosyl-1,3-(N-acetyl-beta-D-glucosaminyl-1,2-alpha-D-mannosyl-1,6)-(N-acetyl-beta-D-glucosaminyl-1,4)-beta-D-mannosyl-1,4-N-acetyl-beta-D-glucosaminyl-R exchange
type: Reaction

metaM dudp c
type: Species
is: C01346
initial amount: NaN
notes: FORMULA: C9H11N2O11P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00768 EHMN_ABBREVIATION: C01346
constant: false
boundary condition: false
name: dUDP
has only substance units: false
is: SBO:0000247
is: CHEBI:60471
is: HMDB01000
initial concentration: 1.0

metaR AICARte
fast: false
is: SBO:0000185
reversible: true
name: Transport of 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide(2-)
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
type: Reaction
kinetic law: MODEL1310110045#
reactant: MODEL1310110045#
product: MODEL1310110045#

metaM CE1935 e
notes: FORMULA: C10H26N3O CHARGE: 3 INCHI: InChI=1/C10H23N3O/c11-5-3-8-12-6-1-2-7-13-9-4-10-14/h10,12-13H,1-9,11H2/p+3 EHMN_ABBREVIATION: CE1935
initial concentration: 1.0
has only substance units: false
is: SBO:0000247
boundary condition: false
initial amount: NaN
name: spermine monoaldehyde
constant: false
type: Species
is: CHEBI:30623
is: HMDB02329

metaM 2docopencoa m
is: HMDB06294
initial amount: NaN
name: 2,7,10,13,16-docosapentenoylcoa
initial concentration: 1.0
has only substance units: false
is: SBO:0000247
notes: FORMULA: C43H64N7O17P3S CHARGE: -4
boundary condition: false
type: Species
constant: false

metaR r2408
name: Mitochondrial Carrier (MC) TCDB:2.A.29.19.1
reactant: MODEL1310110045#
is described by: ECO:0000000
type: Reaction
fast: false
modifier: MODEL1310110045#
notes: GENE_ASSOCIATION: (8402.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172 NOTES:
kinetic law: MODEL1310110045#
is: SBO:0000185
product: MODEL1310110045#
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110045#_c1025537_eae3_4a7f_9911_850888c22085
has only substance units: false
type: Species
is encoded by: hsa:H45672
initial concentration: NaN
constant: false
name: _H45672_1_m
initial amount: NaN
is: SBO:0000252
boundary condition: true

metaR EX arach LPAREN e RPAREN
kinetic law: MODEL1310110045#
reactant: MODEL1310110045#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for arachidate
type: Reaction

metaR PItn
reactant: MODEL1310110045#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: NOTES:IT
is described by: ECO:0000000
name: phosphate transport, nuclear
reversible: true
kinetic law: MODEL1310110045#
is: SBO:0000185
product: MODEL1310110045#
fast: false

metaR EX pan4p LPAREN e RPAREN
kinetic law: MODEL1310110045#
reactant: MODEL1310110045#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for pan4p
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110045#_839c63e9_6e72_4aed_8aa5_a1c55e863ade
constant: false
initial amount: NaN
boundary condition: true
is: Q9Y4C5
type: Species
initial concentration: NaN
has only substance units: false
is: SBO:0000252
is encoded by: hsa:9435
name: CHST2

http://identifiers.org/biomodels.db/MODEL1310110045#_27d20d85_392e_4db7_8ff4_2c16a86e82e2
boundary condition: true
name: NDUFB3
has only substance units: false
initial concentration: NaN
initial amount: NaN
type: Species
is encoded by: hsa:4709
is: Q6IB80
constant: false
is: SBO:0000252

metaM HC02210 e
type: Species
is: CHEBI:34939
is: SBO:0000247
has only substance units: false
notes: FORMULA: C20H29O5 CHARGE: -1 INCHI: InChI=1S/C20H30O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h3-4,6-7,12-13,15-18,21-22H,2,5,8-11,14H2,1H3,(H,24,25)/b6-3-,7-4-,13-12+/t15-,16+,17+,18-/m0/s1
name: prostaglandin-d3
initial concentration: 1.0
constant: false
boundary condition: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110045#_22620a20_0d5f_4f9b_98a5_9e484a29c398
initial amount: NaN
is: SBO:0000252
name: RDH5
boundary condition: true
is encoded by: hsa:5959
initial concentration: NaN
is: Q92781
type: Species
constant: false
has only substance units: false

metaR RE1897C
product: MODEL1310110045#
type: Reaction
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Urea cycle EC Number: 2.5.1.46 Confidence Level: 0 AUTHORS: PMID:9188485 NOTES:
name: RE1897
is: SBO:0000176
reactant: MODEL1310110045#
is described by: ECO:0000000
kinetic law: MODEL1310110045#
fast: false

http://identifiers.org/biomodels.db/MODEL1310110045#_633c9371_e192_46ea_be50_0104e09190ab
is: SBO:0000252
initial amount: NaN
initial concentration: NaN
constant: false
type: Species
name: NME4
has only substance units: false
boundary condition: true
is encoded by: hsa:4833
is: O00746

http://identifiers.org/biomodels.db/MODEL1310110045#_8c3687c2_192b_4b00_a951_ebdfc1c18036
type: Species
initial concentration: NaN
has only substance units: false
boundary condition: true
is encoded by: hsa:10246
name: SLC17A2
initial amount: NaN
is: SBO:0000252
is: O00624
constant: false

http://identifiers.org/biomodels.db/MODEL1310110045#_1148b64f_c2e5_41c1_bca8_c4a1e8099122
initial concentration: NaN
is encoded by: hsa:2530
is: Q546E0
has only substance units: false
initial amount: NaN
constant: false
is: SBO:0000252
type: Species
boundary condition: true
name: FUT8

metaR r2402
product: MODEL1310110045#
name: Mitochondrial Carrier (MC) TCDB:2.A.29.19.1
fast: false
reversible: false
is: SBO:0000185
reactant: MODEL1310110045#
kinetic law: MODEL1310110045#
type: Reaction
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172 NOTES:

metaR r0399
notes: GENE_ASSOCIATION: (4967.1) or (55753.1) SUBSYSTEM: Tetrahydrobiopterin metabolism EC Number: 1.14.16.1 Confidence Level: 0 AUTHORS: PMID:3298976,PMID:4074362 NOTES:
reversible: true
is version of: http://identifiers.org/ec-code/1.2.4.2
kinetic law: MODEL1310110045#
modifier: MODEL1310110045#
reactant: MODEL1310110045#
type: Reaction
product: MODEL1310110045#
is described by: ECO:0000000
name: L-Phenylalanine,tetrahydrobiopterin:oxygen oxidoreductase (4-hydroxylating) Phenylalanine, tyrosine and tryptophan biosynthesis EC:1.14.16.1
fast: false
is: SBO:0000176

metaR PAPtg
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD
kinetic law: MODEL1310110045#
product: MODEL1310110045#
type: Reaction
fast: false
reversible: false
reactant: MODEL1310110045#
name: adenosine 3',5'-bisphosphate Golgi transport
is: SBO:0000185
is described by: ECO:0000000

metaM phe L c
initial amount: NaN
is: CHEBI:17295
is: SBO:0000247
notes: FORMULA: C9H11NO2 CHARGE: 0 INCHI: InChI=1S/C9H11NO2/c10-8(9(11)12)6-7-4-2-1-3-5-7/h1-5,8H,6,10H2,(H,11,12)/t8-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00081 EHMN_ABBREVIATION: C00079
initial concentration: 1.0
has only substance units: false
name: L-phenylalanine
constant: false
is: HMDB00159
type: Species
boundary condition: false

metaM CE5126 x
boundary condition: false
name: (2R)-pristanoyl-CoA
initial amount: NaN
initial concentration: 1.0
has only substance units: false
constant: false
is: SBO:0000247
type: Species
notes: FORMULA: C40H68N7O17P3S CHARGE: -4 INCHI: InChI=1/C40H72N7O17P3S/c1-25(2)11-8-12-26(3)13-9-14-27(4)15-10-16-28(5)39(52)68-20-19-42-30(48)17-18-43-37(51)34(50)40(6,7)22-61-67(58,59)64-66(56,57)60-21-29-33(63-65(53,54)55)32(49)38(62-29)47-24-46-31-35(41)44-23-45-36(31)47/h23-29,32-34,38,49-50H,8-22H2,1-7H3,(H,42,48)(H,43,51)(H,56,57)(H,58,59)(H2,41,44,45)(H2,53,54,55)/p-4/t26-,27-,28-,29-,32+,33+,34u,38-/m0/s1 EHMN_ABBREVIATION: CE5126
is: CHEBI:12947

metaM odecoa c
boundary condition: false
has only substance units: false
initial amount: NaN
is: HMDB01322
notes: FORMULA: C39H64N7O17P3S CHARGE: -4
type: Species
initial concentration: 1.0
constant: false
is: SBO:0000247
name: Octadecenoyl-CoA (n-C18:1CoA)
is: CHEBI:3793

http://identifiers.org/biomodels.db/MODEL1310110045#_1618edd2_1f73_47b8_980e_ca03606c30bf
initial amount: NaN
initial concentration: NaN
is: SBO:0000297
is encoded by: hsa:124
boundary condition: true
type: Species
has part: P07327
has only substance units: false
name: ADH1A:ADH1B
constant: false

metaR DHAAt1r
modifier: MODEL1310110045#
notes: GENE_ASSOCIATION: (6515.1) or (6513.1) or (6517.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10421229,PMID:12750891,PMID:15705056,PMID:2656669,PMID:3170580,PMID:8504756,PMID:9230074 NOTES:NCD
reversible: true
type: Reaction
reactant: MODEL1310110045#
is: SBO:0000185
kinetic law: MODEL1310110045#
name: dehydroascorbate transport (uniport)
is described by: ECO:0000269
product: MODEL1310110045#
fast: false

metaR r1677
type: Reaction
fast: false
is: SBO:0000185
modifier: MODEL1310110045#
is described by: ECO:0000000
reversible: false
kinetic law: MODEL1310110045#
reactant: MODEL1310110045#
name: Y+LAT2 Utilized transport
product: MODEL1310110045#
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:

metaR CSm
modifier: MODEL1310110045#
name: citrate synthase
product: MODEL1310110045#
kinetic law: MODEL1310110045#
reversible: false
type: Reaction
fast: false
notes: GENE_ASSOCIATION: (1431.1) or (1431.2) SUBSYSTEM: Citric acid cycle EC Number: 4.1.3.7 Confidence Level: 0 AUTHORS: PMID:16006620,PMID:9933076 NOTES:IF old EC number (4.1.3.7) is obsolete -- transferred to 2.3.3.1 NCD. Biochemical
reactant: MODEL1310110045#
is described by: ECO:0000134
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.3.3.1

http://identifiers.org/biomodels.db/MODEL1310110045#_fe76f69f_461f_4337_a2b6_3591e5a4d5e7
type: Species
constant: false
has only substance units: false
is encoded by: hsa:AGPAT7
initial concentration: NaN
boundary condition: true
initial amount: NaN
name: _AGPAT7_1_c
is: SBO:0000252

metaR EX 5adtststerone LPAREN e RPAREN
kinetic law: MODEL1310110045#
reactant: MODEL1310110045#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 5alpha-Dihydrotestosterone exchange
type: Reaction

metaR FAOXC102C101m
kinetic law: MODEL1310110045#
product: MODEL1310110045#
reactant: MODEL1310110045#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: reduction(C10:2-->C10:1)m
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110045#_8e6a9616_c197_450f_a0e9_e8c43fd82f8e
type: Species
has only substance units: false
name: NT5C2
initial concentration: NaN
is encoded by: hsa:22978
is: SBO:0000252
initial amount: NaN
is: P49902
boundary condition: true
constant: false

metaR DCSPTN1COAtx
reversible: true
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: NOTES:interaction between peroxisomes and ER (some enzymes on the outer membrane) NJ
reactant: MODEL1310110045#
type: Reaction
product: MODEL1310110045#
name: fatty acid intracellular transport
kinetic law: MODEL1310110045#
is described by: ECO:0000000
fast: false

http://identifiers.org/biomodels.db/MODEL1310110045#_76ae8289_2f75_4996_8cee_fb32d6788fde
has only substance units: false
name: DLAT
type: Species
is: Q86YI5
is encoded by: hsa:1737
initial amount: NaN
constant: false
is: SBO:0000252
initial concentration: NaN
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110045#_33ba28f3_a9ea_491f_aa67_d077813fcecd
type: Species
initial concentration: NaN
is encoded by: hsa:79695
initial amount: NaN
name: GALNT12
is: Q8IXK2
has only substance units: false
is: SBO:0000252
constant: false
boundary condition: true

metaM succ c
is: SBO:0000247
initial amount: NaN
is: HMDB00254
is: CHEBI:30031
is: C00042
type: Species
notes: FORMULA: C4H4O4 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00049 EHMN_ABBREVIATION: C00042
constant: false
has only substance units: false
initial concentration: 1.0
name: Succinate
boundary condition: false

metaM 34dhmald m
is: http://identifiers.org/pubchem.compound/7903
notes: FORMULA: C8H8O4 CHARGE: 0 INCHI: InChI=1/C8H8O4/c9-4-8(12)5-1-2-6(10)7(11)3-5/h1-4,8,10-12H HEPATONET_1.0_ABBREVIATION: HC01514 EHMN_ABBREVIATION: C05577
is: C05577
initial amount: NaN
boundary condition: false
has only substance units: false
type: Species
is: SBO:0000247
is: HMDB06242
constant: false
name: 3,4-Dihydroxymandelaldehyde
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110045#_4c702a3b_01e9_4824_b036_435d4059b6f9
initial amount: NaN
has only substance units: false
initial concentration: NaN
name: AK3
is: SBO:0000252
type: Species
is: E7ET30
constant: false
is encoded by: hsa:50808
boundary condition: true

metaR r2401
name: Mitochondrial Carrier (MC) TCDB:2.A.29.19.1
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172 NOTES:
is described by: ECO:0000000
kinetic law: MODEL1310110045#
type: Reaction
reactant: MODEL1310110045#
is: SBO:0000185
reversible: false
fast: false
product: MODEL1310110045#

http://identifiers.org/biomodels.db/MODEL1310110045#_860108f1_34e5_477b_9bf3_a57de23f2626
boundary condition: true
initial amount: NaN
is encoded by: hsa:4707
has only substance units: false
is: SBO:0000252
constant: false
type: Species
initial concentration: NaN
is: O75438
name: NDUFB1

metaR PItg
reactant: MODEL1310110045#
kinetic law: MODEL1310110045#
reversible: false
fast: false
name: phosphate transport, Golgi apparatus
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 2 AUTHORS: NOTES:NCD
product: MODEL1310110045#
type: Reaction
is: SBO:0000185
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110045#_ecbb8bd4_fefe_4d0c_aa31_fd969c07e574
is: Q7GXY8
name: COX1
has only substance units: false
boundary condition: true
initial amount: NaN
is: SBO:0000252
type: Species
constant: false
initial concentration: NaN
is encoded by: hsa:4512

metaM 34hpp c
name: 3-(4-hydroxyphenyl)pyruvate
notes: FORMULA: C9H7O4 CHARGE: -1 INCHI: InChI=1S/C9H8O4/c10-7-3-1-6(2-4-7)5-8(11)9(12)13/h1-4,10H,5H2,(H,12,13)/p-1 HEPATONET_1.0_ABBREVIATION: HC00699 EHMN_ABBREVIATION: C01179
type: Species
is: SBO:0000247
constant: false
has only substance units: false
initial concentration: 1.0
is: HMDB00707
initial amount: NaN
boundary condition: false
is: CHEBI:36242

metaM dump c
boundary condition: false
initial concentration: 1.0
is: SBO:0000247
initial amount: NaN
type: Species
notes: FORMULA: C9H11N2O8P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00309 EHMN_ABBREVIATION: C00365
is: C00365
name: dUMP
is: CHEBI:246422
has only substance units: false
is: HMDB01409
constant: false

http://identifiers.org/biomodels.db/MODEL1310110045#_d8ed3f15_e7c1_40d8_a9f5_18683e9580b3
type: Species
is encoded by: hsa:55568
has only substance units: false
name: GALNT10
initial amount: NaN
initial concentration: NaN
constant: false
is: SBO:0000252
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110045#_7609d768_9c37_4775_bea5_70a926c6e1cf
has only substance units: false
initial concentration: NaN
is encoded by: hsa:93034
constant: false
name: NT5C1B
boundary condition: true
is: SBO:0000252
type: Species
is: Q96P26
initial amount: NaN

metaM phe L e
is: CHEBI:17295
notes: FORMULA: C9H11NO2 CHARGE: 0 INCHI: InChI=1S/C9H11NO2/c10-8(9(11)12)6-7-4-2-1-3-5-7/h1-5,8H,6,10H2,(H,11,12)/t8-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00081 EHMN_ABBREVIATION: C00079
type: Species
has only substance units: false
initial concentration: 1.0
boundary condition: false
name: L-phenylalanine
is: SBO:0000247
constant: false
initial amount: NaN
is: HMDB00159

metaM glyc R m
constant: false
is: HMDB00139
is: SBO:0000247
is: CHEBI:16659
notes: FORMULA: C3H5O4 CHARGE: -1 INCHI: InChI=1S/C3H6O4/c4-1-2(5)3(6)7/h2,4-5H,1H2,(H,6,7)/p-1/t2-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00235
type: Species
boundary condition: false
initial amount: NaN
has only substance units: false
name: D-glycerate
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110045#_1b691bda_b90e_4540_910e_fdf8321d55d1
is: Q8WXF9
is: SBO:0000252
initial amount: NaN
type: Species
has only substance units: false
boundary condition: true
initial concentration: NaN
name: SLC2A11
constant: false
is encoded by: hsa:66035

metaR EX ribflv LPAREN e RPAREN
kinetic law: MODEL1310110045#
reactant: MODEL1310110045#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for Riboflavin
type: Reaction

metaM coa n
boundary condition: false
initial concentration: 1.0
is: SBO:0000247
name: coenzyme A(4-)
notes: FORMULA: C21H32N7O16P3S CHARGE: -4 INCHI: InChI=1S/C21H36N7O16P3S/c1-21(2,16(31)19(32)24-4-3-12(29)23-5-6-48)8-41-47(38,39)44-46(36,37)40-7-11-15(43-45(33,34)35)14(30)20(42-11)28-10-27-13-17(22)25-9-26-18(13)28/h9-11,14-16,20,30-31,48H,3-8H2,1-2H3,(H,23,29)(H,24,32)(H,36,37)(H,38,39)(H2,22,25,26)(H2,33,34,35)/p-4/t11-,14-,15-,16+,20-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00020 EHMN_ABBREVIATION: C00010
type: Species
is: CHEBI:57287
is: HMDB01423
initial amount: NaN
constant: false
has only substance units: false

metaR PHETHPTOX2
is: SBO:0000176
is described by: ECO:0000269
type: Reaction
notes: GENE_ASSOCIATION: (5053.1) SUBSYSTEM: Phenylalanine metabolism EC Number: 1.14.16.1 Confidence Level: 4 AUTHORS: PMID:10727395,PMID:9450897 NOTES:SAB unlumped form of PHETHPTOX according to PMID 10727395
product: MODEL1310110045#
is version of: http://identifiers.org/ec-code/1.14.16.1
reversible: false
name: L-Phenylalanine,tetrahydrobiopterin:oxygen oxidoreductase (4-hydroxylating)
kinetic law: MODEL1310110045#
reactant: MODEL1310110045#
fast: false
modifier: MODEL1310110045#

metaM i c
has only substance units: false
initial concentration: 1.0
constant: false
name: iodide
boundary condition: false
initial amount: NaN
is: CHEBI:16382
is: SBO:0000247
is: HMDB12238
type: Species
notes: FORMULA: I CHARGE: -1 INCHI: InChI=1S/HI/h1H/p-1 EHMN_ABBREVIATION: C00708

metaR 3MOPt2im
is described by: ECO:0000000
type: Reaction
product: MODEL1310110045#
kinetic law: MODEL1310110045#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:8428987 NOTES:MM
fast: false
name: 3-Methyl-2-oxopentanoate mitochondrial transport via proton symport
reversible: false
is: SBO:0000185
reactant: MODEL1310110045#

metaM coa m
initial amount: NaN
is: C00010
constant: false
has only substance units: false
name: Coenzyme A
is: CHEBI:57287
is: HMDB01423
is: SBO:0000247
notes: FORMULA: C21H32N7O16P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00020 EHMN_ABBREVIATION: C00010
type: Species
boundary condition: false
initial concentration: 1.0

metaM 34hpp e
is: SBO:0000247
constant: false
type: Species
name: 3-(4-hydroxyphenyl)pyruvate
notes: FORMULA: C9H7O4 CHARGE: -1 INCHI: InChI=1S/C9H8O4/c10-7-3-1-6(2-4-7)5-8(11)9(12)13/h1-4,10H,5H2,(H,12,13)/p-1
is: HMDB00707
initial amount: NaN
initial concentration: 1.0
has only substance units: false
is: CHEBI:36242
boundary condition: false

metaR EX hista LPAREN e RPAREN
kinetic law: MODEL1310110045#
reactant: MODEL1310110045#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Histamine exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110045#_f8f71b38_7cd0_425e_81e4_0ac7703e4fc8
is encoded by: hsa:10400
initial amount: NaN
has only substance units: false
boundary condition: true
is: SBO:0000252
type: Species
name: PEMT
constant: false
initial concentration: NaN

metaR RE2069C
is: SBO:0000176
is described by: ECO:0000000
product: MODEL1310110045#
reversible: true
name: RE2069
reactant: MODEL1310110045#
notes: GENE_ASSOCIATION: SUBSYSTEM: Eicosanoid metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:11447235 NOTES:
kinetic law: MODEL1310110045#
type: Reaction
fast: false

metaR r1568
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reactant: MODEL1310110045#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
kinetic law: MODEL1310110045#
type: Reaction
is: SBO:0000185
reversible: true
product: MODEL1310110045#
is described by: ECO:0000000
fast: false

metaR FAOXOHC16C16DCc
kinetic law: MODEL1310110045#
product: MODEL1310110045#
reactant: MODEL1310110045#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid omega oxidation(w-OHC16-->C16DC)c
type: Reaction

metaM glc D c
notes: FORMULA: C6H12O6 CHARGE: 0 INCHI: InChI=1S/C6H12O6/c7-1-2-3(8)4(9)5(10)6(11)12-2/h2-11H,1H2/t2-,3-,4+,5-,6?/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00040
has only substance units: false
initial amount: NaN
name: D-glucose
type: Species
is: CHEBI:4167
is: SBO:0000247
initial concentration: 1.0
is: HMDB00122
boundary condition: false
constant: false

http://identifiers.org/biomodels.db/MODEL1310110045#_metaR_EX_s2l2fn2m2masn_LPAREN_e_RPAREN_
kinetic law: MODEL1310110045#
reactant: MODEL1310110045#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: PA6 exchange
type: Reaction

metaM dcyt e
notes: FORMULA: C9H13N3O4 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00574 EHMN_ABBREVIATION: C00881
is: HMDB00014
is: CHEBI:15698
initial amount: NaN
type: Species
is: C00881
has only substance units: false
constant: false
initial concentration: 1.0
is: SBO:0000247
name: Deoxycytidine
boundary condition: false

metaR ADPtx
is: SBO:0000185
name: ADP transporter, peroxisomal
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 1 AUTHORS: NOTES:most likely NOT physiological - detailed information about the peroxisomal transporters has not yet been achieved - this transport is most likely dependent on a concomitant energy consuming reaction (human ABC peroxisomal transporters: PEX family - check in future for new research articles describing biochemistry and stoichiometry) NJ
is described by: ECO:0000000
reversible: true
reactant: MODEL1310110045#
fast: false
kinetic law: MODEL1310110045#
product: MODEL1310110045#
type: Reaction

metaR PI4PLC
type: Reaction
is version of: http://identifiers.org/ec-code/3.1.4.11
fast: false
kinetic law: MODEL1310110045#
is described by: ECO:0000269
reactant: MODEL1310110045#
notes: GENE_ASSOCIATION: (23236.1) or (51196.1) or (9651.1) or (113026.1) or (89869.1) or (23007.1) or (5334.1) or (5331.1) or (5333.1) or (257068.1) or (5332.1) or (23236.2) or (5335.1) or (5335.2) or (5336.1) or (5330.1) or (5332.2) or (84812.1) SUBSYSTEM: Inositol phosphate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:10702670,PMID:10702683,PMID:10760467,PMID:11022047,PMID:11022048,PMID:11118617,PMID:12117804,PMID:12213492,PMID:12416999,PMID:13333955,PMID:15140260,PMID:1644792,PMID:2167438,PMID:7607669,PMID:7612006,PMID:7633416,PMID:7789993,PMID:7835906,PMID:7849701,PMID:7890667,PMID:8530101,PMID:9345909 NOTES:NCD
product: MODEL1310110045#
name: phosphatidylinositol 4-phosphate phospholipase C
modifier: MODEL1310110045#
reversible: false
is: SBO:0000176

metaR r0181
kinetic law: MODEL1310110045#
type: Reaction
fast: false
reactant: MODEL1310110045#
modifier: MODEL1310110045#
product: MODEL1310110045#
notes: GENE_ASSOCIATION: (AA081045.1) or (AI620219.1) or (220.1) or (219.1) or (217.1) or (218.1) or (224.1) or (221.1) or (222.1) or (501.1) or (223.1) or (AU149534.1) or (T83654.1) or (U37519.1) SUBSYSTEM: Purine catabolism EC Number: 3.6.1.5 Confidence Level: 0 AUTHORS: PMID:15652174,PMID:16752921,PMID:17095758 NOTES:
is: SBO:0000176
reversible: true
is described by: ECO:0000000
name: ITP diphosphohydrolase Purine metabolism EC:3.6.1.5
is version of: http://identifiers.org/ec-code/1.2.1.5
is version of: http://identifiers.org/ec-code/1.2.1.3

metaR EX uri LPAREN e RPAREN
kinetic law: MODEL1310110045#
reactant: MODEL1310110045#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for Uridine
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110045#_c4680d1c_2141_4f97_b6c0_40c889af001c
has only substance units: false
is encoded by: hsa:NM 001929
boundary condition: true
initial amount: NaN
initial concentration: NaN
is: SBO:0000252
name: _NM_001929_1_c
type: Species
constant: false

metaR DM atp c
name: DM_atp(c)
is described by: ECO:0000134
reversible: false
product: MODEL1310110045#
is: SBO:0000176
fast: false
kinetic law: MODEL1310110045#
reactant: MODEL1310110045#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: AUTHORS: NOTES:
type: Reaction

metaR r1569
product: MODEL1310110045#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
type: Reaction
fast: false
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reversible: true
is described by: ECO:0000000
reactant: MODEL1310110045#
kinetic law: MODEL1310110045#
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110045#_92f7346c_7d97_4a47_a3e2_49d7a2d702a6
is encoded by: hsa:9563
initial amount: NaN
has only substance units: false
is: SBO:0000252
constant: false
boundary condition: true
is: O95479
type: Species
initial concentration: NaN
name: H6PD

metaM CE2422 m
name: 3-oxo-cis,cis-7,10-hexadecadienoyl-CoA
constant: false
type: Species
has only substance units: false
initial amount: NaN
boundary condition: false
notes: FORMULA: C37H56N7O18P3S CHARGE: -4 INCHI: InChI=1/C37H60N7O18P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-25(45)20-28(47)66-19-18-39-27(46)16-17-40-35(50)32(49)37(2,3)22-59-65(56,57)62-64(54,55)58-21-26-31(61-63(51,52)53)30(48)36(60-26)44-24-43-29-33(38)41-23-42-34(29)44/h8-9,11-12,23-24,26,30-32,36,48-49H,4-7,10,13-22H2,1-3H3,(H,39,46)(H,40,50)(H,54,55)(H,56,57)(H2,38,41,42)(H2,51,52,53)/p-4/b9-8-,12-11-/t26-,30+,31+,32u,36-/m0/s1 EHMN_ABBREVIATION: CE2422
is: HMDB11123
is: CHEBI:28387
is: SBO:0000247
initial concentration: 1.0

metaR S6T1g
modifier: MODEL1310110045#
name: galactose/N-acetylglucosamine 6-O-sulfotransferase, Golgi apparatus
reactant: MODEL1310110045#
kinetic law: MODEL1310110045#
fast: false
type: Reaction
is: SBO:0000176
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (23563.2) or (9435.1) or (23563.1) or (10164.1) or (4166.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: Confidence Level: 4 AUTHORS: PMID:10330415,PMID:10491328,PMID:10913333,PMID:11278593,PMID:12403612,PMID:12855678,PMID:9722682 NOTES:NCD
reversible: false
product: MODEL1310110045#

metaR r0394
fast: false
product: MODEL1310110045#
is: SBO:0000176
reactant: MODEL1310110045#
type: Reaction
reversible: true
kinetic law: MODEL1310110045#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Nucleotide interconversion EC Number: 1.17.1.4 Confidence Level: 0 AUTHORS: PMID:2713424,PMID:8248161 NOTES:
name: Xanthine:NAD+ oxidoreductase Purine metabolism EC:1.17.1.4

metaM ump g
is: HMDB00288
is: CHEBI:57865
constant: false
name: UMP(2-)
notes: FORMULA: C9H11N2O9P CHARGE: -2 INCHI: InChI=1S/C9H13N2O9P/c12-5-1-2-11(9(15)10-5)8-7(14)6(13)4(20-8)3-19-21(16,17)18/h1-2,4,6-8,13-14H,3H2,(H,10,12,15)(H2,16,17,18)/p-2/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00105 EHMN_ABBREVIATION: C00105
has only substance units: false
boundary condition: false
is: SBO:0000247
type: Species
initial amount: NaN
initial concentration: 1.0

metaR EX nh4 LPAREN e RPAREN
kinetic law: MODEL1310110045#
reactant: MODEL1310110045#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Ammonia exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110045#_af172f9d_0129_4d71_bfaa_fa2f50e5e197
boundary condition: true
constant: false
is: SBO:0000252
initial concentration: NaN
name: _C7orf24_1_m
is encoded by: hsa:C7orf24
type: Species
initial amount: NaN
has only substance units: false

metaR ACACT1rm
product: MODEL1310110045#
kinetic law: MODEL1310110045#
fast: false
type: Reaction
reversible: true
is version of: http://identifiers.org/ec-code/4.2.1.17
reactant: MODEL1310110045#
is: SBO:0000176
notes: GENE_ASSOCIATION: (3030.1) and (3032.1) or (38.1) SUBSYSTEM: Tryptophan metabolism EC Number: 2.3.1.9 Confidence Level: 0 AUTHORS: NOTES:TDV
is version of: http://identifiers.org/ec-code/2.3.1.9
is version of: http://identifiers.org/ec-code/2.3.1.16
modifier: MODEL1310110045#
name: acetyl-CoA C-acetyltransferase, mitochondrial
is described by: ECO:0000000

metaR r1566
is described by: ECO:0000000
fast: false
kinetic law: MODEL1310110045#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reactant: MODEL1310110045#
type: Reaction
reversible: true
product: MODEL1310110045#
is: SBO:0000185
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1

metaM coa r
initial amount: NaN
is: C00010
type: Species
is: SBO:0000247
is: CHEBI:57287
name: Coenzyme A
constant: false
initial concentration: 1.0
boundary condition: false
notes: FORMULA: C21H32N7O16P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00020 EHMN_ABBREVIATION: C00010
has only substance units: false
is: HMDB01423

metaR CYTK13n
name: cytidylate kinase (dCMP,dATP),nuclear
product: MODEL1310110045#
reversible: true
kinetic law: MODEL1310110045#
modifier: MODEL1310110045#
fast: false
type: Reaction
reactant: MODEL1310110045#
is: SBO:0000176
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
is version of: http://identifiers.org/ec-code/2.7.4.14

metaR q10tm
kinetic law: MODEL1310110045#
is: SBO:0000185
reactant: MODEL1310110045#
name: transport of ubiquinone into mitochondria
product: MODEL1310110045#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: NOTES:
fast: false
type: Reaction
reversible: true
is described by: ECO:0000134

metaM glc D e
notes: FORMULA: C6H12O6 CHARGE: 0 INCHI: InChI=1S/C6H12O6/c7-1-2-3(8)4(9)5(10)6(11)12-2/h2-11H,1H2/t2-,3-,4+,5-,6?/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00040
type: Species
has only substance units: false
is: SBO:0000247
is: CHEBI:4167
name: D-glucose
is: HMDB00122
constant: false
initial concentration: 1.0
boundary condition: false
initial amount: NaN

metaR r1259
name: EC:6.2.1.3
reversible: false
kinetic law: MODEL1310110045#
product: MODEL1310110045#
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 0 AUTHORS: PMID:8584017 NOTES:
fast: false
type: Reaction
is: SBO:0000176
reactant: MODEL1310110045#
is described by: ECO:0000000

metaM 42A3HP24DB c
notes: FORMULA: C10H8NO5 CHARGE: -1 INCHI: InChI=1/C10H9NO5/c11-9-5(2-1-3-6(9)12)7(13)4-8(14)10(15)16/h1-3,12H,4,11H2,(H,15,16) HEPATONET_1.0_ABBREVIATION: HC01547 EHMN_ABBREVIATION: C05645
has only substance units: false
is: SBO:0000247
name: 4-(2-Amino-3-hydroxyphenyl)-2,4-dioxobutanoate
is: http://identifiers.org/pubchem.compound/7956
initial concentration: 1.0
constant: false
type: Species
initial amount: NaN
is: C05645
boundary condition: false
is: HMDB04083

metaR ACt2r
name: acetate reversible transport via proton symport
reversible: true
product: MODEL1310110045#
is: SBO:0000185
fast: false
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:9651205 NOTES:NCD
is described by: ECO:0000000
kinetic law: MODEL1310110045#
reactant: MODEL1310110045#

metaR HMGLx
kinetic law: MODEL1310110045#
is described by: ECO:0000134
is version of: http://identifiers.org/ec-code/4.1.3.4
is: SBO:0000176
product: MODEL1310110045#
modifier: MODEL1310110045#
reversible: false
notes: GENE_ASSOCIATION: (3155.1) SUBSYSTEM: Cholesterol metabolism EC Number: 4.1.3.4 Confidence Level: 4 AUTHORS: PMID:11111079 NOTES:TV NJ added peroxisomal version - see Olivier Biochimica et Biophysica Act 1529 (2000) 89-102
fast: false
type: Reaction
reactant: MODEL1310110045#
name: hydroxymethylglutaryl-CoA lyase

http://identifiers.org/biomodels.db/MODEL1310110045#_5cdbcb7c_3d92_4a69_8728_d1e496b4536f
name: ATP2B1
is: SBO:0000252
initial concentration: NaN
is encoded by: hsa:490
type: Species
has only substance units: false
initial amount: NaN
boundary condition: true
is: P20020
constant: false

http://identifiers.org/biomodels.db/MODEL1310110045#_816a0362_3639_4157_a163_e12a94378cc1
has only substance units: false
constant: false
type: Species
initial amount: NaN
is encoded by: hsa:51703
boundary condition: true
is: SBO:0000252
initial concentration: NaN
is: Q9ULC5
name: ACSL5

http://identifiers.org/biomodels.db/MODEL1310110045#_ed26171e_ee90_4011_84dd_d1a868823311
constant: false
initial concentration: NaN
is: SBO:0000252
name: LEFTY1
has only substance units: false
boundary condition: true
type: Species
is: O75610
initial amount: NaN
is encoded by: hsa:10637

metaR KSII CORE2t
fast: false
is described by: ECO:0000000
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:
reactant: MODEL1310110045#
reversible: false
product: MODEL1310110045#
kinetic law: MODEL1310110045#
is: SBO:0000185
name: keratan sulfate II (core2) transport, golgi to extracellular

metaR r0393
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.7.1.74
product: MODEL1310110045#
modifier: MODEL1310110045#
fast: false
name: D-Glyceraldehyde:NAD+ oxidoreductase Glycerolipid metabolism EC:1.2.1.3
type: Reaction
notes: GENE_ASSOCIATION: (1633.1) SUBSYSTEM: Unassigned EC Number: 1.2.1.3 Confidence Level: 0 AUTHORS: PMID:12705826,PMID:170276,PMID:6189823,PMID:6285247,PMID:8155713 NOTES:
is described by: ECO:0000000
reversible: false
kinetic law: MODEL1310110045#
reactant: MODEL1310110045#

metaR r1567
product: MODEL1310110045#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
fast: false
type: Reaction
reversible: true
kinetic law: MODEL1310110045#
is described by: ECO:0000000
reactant: MODEL1310110045#

metaR NH4tp
type: Reaction
name: ammonia peroxisomal transport
kinetic law: MODEL1310110045#
is: SBO:0000185
reactant: MODEL1310110045#
reversible: true
fast: false
product: MODEL1310110045#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110045#_7f379720_0b78_469b_bad2_9f1c07a8f3ab
is encoded by: hsa:54539
name: NDUFB11
is: Q9NX14
initial amount: NaN
initial concentration: NaN
has only substance units: false
is: SBO:0000252
type: Species
boundary condition: true
constant: false

metaR EX citr L LPAREN e RPAREN
kinetic law: MODEL1310110045#
reactant: MODEL1310110045#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: L-citrulline exchange
type: Reaction

metaM btn n
is: SBO:0000247
initial amount: NaN
has only substance units: false
initial concentration: 1.0
name: biotinate
boundary condition: false
is: CHEBI:57586
constant: false
type: Species
notes: FORMULA: C10H15N2O3S CHARGE: -1 INCHI: InChI=1S/C10H16N2O3S/c13-8(14)4-2-1-3-7-9-6(5-16-7)11-10(15)12-9/h6-7,9H,1-5H2,(H,13,14)(H2,11,12,15)/p-1/t6-,7-,9-/m0/s1 EHMN_ABBREVIATION: C00120
is: HMDB00030

metaM mlthf m
initial amount: NaN
has only substance units: false
notes: FORMULA: C20H21N7O6 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00140 EHMN_ABBREVIATION: C00143
constant: false
name: 5,10-Methylenetetrahydrofolate
is: HMDB01533
is: SBO:0000247
initial concentration: 1.0
is: C00143
type: Species
is: CHEBI:15636
boundary condition: false

metaR EX dha LPAREN e RPAREN
kinetic law: MODEL1310110045#
reactant: MODEL1310110045#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of glycerone
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110045#_65004dbf_ab68_48a0_8574_4e021a2c98c3
constant: false
is: P50213
is encoded by: hsa:3419
name: IDH3A
is: SBO:0000252
has only substance units: false
type: Species
boundary condition: true
initial amount: NaN
initial concentration: NaN

metaM ksi deg35 l
boundary condition: false
initial concentration: 1.0
name: keratan sulfate I, degradation product 35
is: SBO:0000247
notes: FORMULA: C68H113N4O54S1 CHARGE: -1
has only substance units: false
constant: false
initial amount: NaN
is: CHEBI:12936
is: HMDB00143
type: Species

metaM btn m
is: SBO:0000247
boundary condition: false
notes: FORMULA: C10H15N2O3S CHARGE: -1 INCHI: InChI=1S/C10H16N2O3S/c13-8(14)4-2-1-3-7-9-6(5-16-7)11-10(15)12-9/h6-7,9H,1-5H2,(H,13,14)(H2,11,12,15)/p-1/t6-,7-,9-/m0/s1 EHMN_ABBREVIATION: C00120
is: CHEBI:57586
name: biotinate
initial concentration: 1.0
type: Species
constant: false
is: HMDB00030
has only substance units: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110045#_47afefcd_da4c_41dc_8676_4bb25ad099d1
constant: false
is encoded by: hsa:9791
type: Species
initial concentration: NaN
initial amount: NaN
is: P48651
name: PTDSS1
boundary condition: true
has only substance units: false
is: SBO:0000252

metaR AG13T11g
is version of: http://identifiers.org/ec-code/2.4.1.149
type: Reaction
is: SBO:0000176
name: N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase, Golgi apparatus
fast: false
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (79369.1) or (374907.1) or (11041.1) or (146712.1) or (374907.2) or (93010.1) or (10331.1) or (10678.1) or (10678.2) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.149 Confidence Level: 4 AUTHORS: PMID:10747980,PMID:11042166,PMID:12061784,PMID:12512857,PMID:15560372,PMID:15620693,PMID:9405606 NOTES:NCD
product: MODEL1310110045#
reversible: false
kinetic law: MODEL1310110045#
modifier: MODEL1310110045#
reactant: MODEL1310110045#

metaM ksi pre30 g
notes: FORMULA: C219H350N15O184S9X CHARGE: -10
type: Species
is: C00130
is: HMDB00175
constant: false
initial amount: NaN
is: CHEBI:58053
is: SBO:0000247
name: keratan sulfate I biosynthesis, precursor 30
boundary condition: false
initial concentration: 1.0
has only substance units: false

metaR RE3273C
name: RE3273
kinetic law: MODEL1310110045#
is version of: http://identifiers.org/ec-code/3.1.4.4
fast: false
notes: GENE_ASSOCIATION: (5338.1) SUBSYSTEM: Phosphatidylinositol phosphate metabolism EC Number: 3.1.4.4 Confidence Level: 0 AUTHORS: PMID:3135804 NOTES:
is: SBO:0000176
reversible: true
modifier: MODEL1310110045#
product: MODEL1310110045#
reactant: MODEL1310110045#
is described by: ECO:0000000
type: Reaction

metaM msa m
is: HMDB11111
is: CHEBI:33190
is: SBO:0000247
constant: false
type: Species
has only substance units: false
initial concentration: 1.0
name: 3-oxopropanoate
initial amount: NaN
notes: FORMULA: C3H3O3 CHARGE: -1 INCHI: InChI=1S/C3H4O3/c4-2-1-3(5)6/h2H,1H2,(H,5,6)/p-1 HEPATONET_1.0_ABBREVIATION: HC00203 EHMN_ABBREVIATION: C00222
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110045#_fbfbcde8_d23b_4592_9784_d253cfa9198e
constant: false
name: SLC9A4
is encoded by: hsa:389015
has only substance units: false
initial amount: NaN
type: Species
is: Q6AI14
is: SBO:0000252
initial concentration: NaN
boundary condition: true

metaR FAOXC160
name: Beta oxidation of long chain fatty acid
reactant: MODEL1310110045#
notes: GENE_ASSOCIATION: (34.1) or (35.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.99.3 Confidence Level: 4 AUTHORS: PMID:2565344,PMID:3035565 NOTES:TV Other enzymes: 1.3.3.6, 4.2.1.74, 4.2.1.17, 1.1.1.35, 1.1.1.211
reversible: false
modifier: MODEL1310110045#
product: MODEL1310110045#
is version of: http://identifiers.org/ec-code/1.3.99.3
is described by: ECO:0000269
fast: false
is: SBO:0000176
kinetic law: MODEL1310110045#
is version of: http://identifiers.org/ec-code/1.3.8.1
type: Reaction

metaM glyc R c
notes: FORMULA: C3H5O4 CHARGE: -1 INCHI: InChI=1S/C3H6O4/c4-1-2(5)3(6)7/h2,4-5H,1H2,(H,6,7)/p-1/t2-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00235
constant: false
type: Species
has only substance units: false
is: SBO:0000247
name: D-glycerate
boundary condition: false
is: CHEBI:16659
initial concentration: 1.0
is: HMDB00139
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110045#_77c03779_64c3_4495_8f2c_6aeb5bb42faf
is: P19801
name: ABP1
type: Species
is encoded by: hsa:26
is: SBO:0000252
boundary condition: true
initial amount: NaN
has only substance units: false
initial concentration: NaN
constant: false

http://identifiers.org/biomodels.db/MODEL1310110045#_7b38b91d_a58a_4f77_a28b_e6284c847131
name: ST3GAL3
boundary condition: true
type: Species
constant: false
is encoded by: hsa:6487
initial concentration: NaN
is: SBO:0000252
initial amount: NaN
has only substance units: false

metaM gluside hs r
has only substance units: false
initial amount: NaN
type: Species
constant: false
notes: FORMULA: C24H46NO7FULLRCO CHARGE: 0 EHMN_ABBREVIATION: C01190
initial concentration: 1.0
is: SBO:0000247
boundary condition: false
name: D-glucosyl-N-acylsphingosine
is: CHEBI:18368

metaM trp L c
initial amount: NaN
constant: false
type: Species
initial concentration: 1.0
is: HMDB00929
name: L-tryptophan
is: SBO:0000247
notes: FORMULA: C11H12N2O2 CHARGE: 0 INCHI: InChI=1S/C11H12N2O2/c12-9(11(14)15)5-7-6-13-10-4-2-1-3-8(7)10/h1-4,6,9,13H,5,12H2,(H,14,15)/t9-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00080
boundary condition: false
is: CHEBI:16828
has only substance units: false

metaR r0391
type: Reaction
product: MODEL1310110045#
notes: GENE_ASSOCIATION: SUBSYSTEM: NAD metabolism EC Number: 2.4.2.11 Confidence Level: 0 AUTHORS: PMID:17604275 NOTES:
is described by: ECO:0000000
reversible: true
reactant: MODEL1310110045#
name: Nicotinate D-ribonucleotide:pyrophosphate phosphoribosyltransferase Nicotinate and nicotinamide metabolism EC:2.4.2.11
fast: false
kinetic law: MODEL1310110045#
is: SBO:0000176

metaR NAGLCAly
kinetic law: MODEL1310110045#
fast: false
is: SBO:0000176
type: Reaction
product: MODEL1310110045#
reactant: MODEL1310110045#
notes: GENE_ASSOCIATION: SUBSYSTEM: Keratan sulfate degradation EC Number: Confidence Level: 1 AUTHORS: NOTES:EC 3.2.1.- This reaction is my best guess at how the GlcNAc-beta-1,6-GalNAc linkage is cleaved. NCD
is described by: ECO:0000000
name: N-acetylglucosaminidase, lysosomal
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110045#_0d3e905a_e048_4a48_9df6_affff733f2d7
constant: false
is: SBO:0000252
name: GPX2
is encoded by: hsa:2877
type: Species
initial concentration: NaN
initial amount: NaN
has only substance units: false
boundary condition: true
is: P18283

http://identifiers.org/biomodels.db/MODEL1310110045#_5c50db33_d289_47be_ab5f_0ae61df6fb77
name: FUT8
initial amount: NaN
constant: false
is encoded by: hsa:2530
has only substance units: false
is: SBO:0000252
boundary condition: true
type: Species
is: A8K8P8
initial concentration: NaN

metaR NMNATr
kinetic law: MODEL1310110045#
type: Reaction
is described by: ECO:0000269
is: SBO:0000176
modifier: MODEL1310110045#
notes: GENE_ASSOCIATION: (349565.1) or (23057.1) or (23057.2) SUBSYSTEM: NAD metabolism EC Number: Confidence Level: 4 AUTHORS: NOTES:
reactant: MODEL1310110045#
reversible: true
product: MODEL1310110045#
name: nicotinamide-nucleotide adenylyltransferase
is version of: http://identifiers.org/ec-code/2.7.7.1
fast: false

metaM ump c
initial amount: NaN
is: CHEBI:57865
notes: FORMULA: C9H11N2O9P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00105 EHMN_ABBREVIATION: C00105
constant: false
is: SBO:0000247
is: HMDB00288
initial concentration: 1.0
type: Species
has only substance units: false
boundary condition: false
name: UMP
is: C00105

metaR NH4tn
fast: false
reversible: true
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 1 AUTHORS: NOTES:IT
product: MODEL1310110045#
name: ammonia nuclear transport
reactant: MODEL1310110045#
kinetic law: MODEL1310110045#
is: SBO:0000185
is described by: ECO:0000000

metaM coa x
notes: FORMULA: C21H32N7O16P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00020 EHMN_ABBREVIATION: C00010
is: HMDB01423
boundary condition: false
has only substance units: false
is: C00010
name: Coenzyme A
initial concentration: 1.0
initial amount: NaN
type: Species
constant: false
is: SBO:0000247
is: CHEBI:57287

metaM HC02210 c
type: Species
boundary condition: false
notes: FORMULA: C20H29O5 CHARGE: -1 INCHI: InChI=1S/C20H30O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h3-4,6-7,12-13,15-18,21-22H,2,5,8-11,14H2,1H3,(H,24,25)/b6-3-,7-4-,13-12+/t15-,16+,17+,18-/m0/s1
has only substance units: false
constant: false
initial concentration: 1.0
is: CHEBI:34939
initial amount: NaN
name: prostaglandin-d3
is: SBO:0000247

metaR r2409
reactant: MODEL1310110045#
is described by: ECO:0000000
type: Reaction
product: MODEL1310110045#
is: SBO:0000185
reversible: false
name: Mitochondrial Carrier (MC) TCDB:2.A.29.19.1
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172 NOTES:
kinetic law: MODEL1310110045#

metaR r0390
reversible: true
product: MODEL1310110045#
is: SBO:0000176
name: Isomaltose 6-alpha-D-glucanohydrolase Starch and sucrose metabolism EC:3.2.1.10
reactant: MODEL1310110045#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 3.2.1.10 Confidence Level: 0 AUTHORS: PMID:17194452 NOTES:
kinetic law: MODEL1310110045#
type: Reaction
is described by: ECO:0000000

metaM o2s m
is: CHEBI:18421
boundary condition: false
type: Species
is: SBO:0000247
is: HMDB02168
notes: FORMULA: O2 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00505 EHMN_ABBREVIATION: C00704
constant: false
name: Superoxide anion
initial concentration: 1.0
has only substance units: false
initial amount: NaN
is: C00704

http://identifiers.org/biomodels.db/MODEL1310110045#_3f9ce532_0f31_4723_8e49_f11036645ce2
boundary condition: true
has only substance units: false
type: Species
constant: false
is encoded by: hsa:11226
is: SBO:0000252
initial concentration: NaN
initial amount: NaN
is: Q8NCL4
name: GALNT6

metaM gar c
has only substance units: false
is: SBO:0000247
initial concentration: 1.0
notes: FORMULA: C7H14N2O8P CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC01190 EHMN_ABBREVIATION: C03838
is: C03838
is: CHEBI:58457
boundary condition: false
type: Species
constant: false
is: HMDB02022
name: N1-(5-Phospho-D-ribosyl)glycinamide
initial amount: NaN

metaR S6TASE22ly
is version of: http://identifiers.org/ec-code/3.2.1.18
modifier: MODEL1310110045#
product: MODEL1310110045#
is version of: http://identifiers.org/ec-code/3.4.16.5
reversible: true
is: SBO:0000176
reactant: MODEL1310110045#
name: galactose-6-sulfate sulfatase, lysosomal
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.1.6.4 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD
is version of: http://identifiers.org/ec-code/3.1.6.4
type: Reaction
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/3.2.1.23
fast: false
kinetic law: MODEL1310110045#

http://identifiers.org/biomodels.db/MODEL1310110045#_57bc9ce2_8309_4fa1_8849_a97e07bdfdbb
boundary condition: true
name: CHKA
initial amount: NaN
initial concentration: NaN
is: SBO:0000252
has only substance units: false
is encoded by: hsa:1119
type: Species
is: P35790
constant: false

metaR DM Ser Gly Ala X Gly ly
kinetic law: MODEL1310110045#
reactant: MODEL1310110045#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 0 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: false
name: DM Ser-Gly/Ala-X-Gly(ly)
type: Reaction

metaM dcyt c
boundary condition: false
is: C00881
constant: false
type: Species
is: SBO:0000247
notes: FORMULA: C9H13N3O4 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00574 EHMN_ABBREVIATION: C00881
initial concentration: 1.0
is: HMDB00014
initial amount: NaN
is: CHEBI:15698
name: Deoxycytidine
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110045#_07a24b4f_48a1_41bb_ac97_e1040c139500
is encoded by: hsa:8394
initial concentration: NaN
boundary condition: true
type: Species
initial amount: NaN
is: Q99755
is: SBO:0000252
name: PIP5K1A
has only substance units: false
constant: false

metaR EX HC02205 LPAREN e RPAREN
kinetic law: MODEL1310110045#
reactant: MODEL1310110045#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: prostaglandin-b2 exchange
type: Reaction

metaM ksii core2 pre8 g
initial concentration: 1.0
is: C00130
name: keratan sulfate II biosynthesis, precursor 8
initial amount: NaN
is: HMDB00175
notes: FORMULA: C75H121N6O56SX CHARGE: -2
is: SBO:0000247
constant: false
is: CHEBI:58053
boundary condition: false
type: Species
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110045#_84e0d3e4_b49f_4340_8350_3867013fc83e
type: Species
name: _AA177072_1_c
initial amount: NaN
is encoded by: hsa:AA177072
initial concentration: NaN
has only substance units: false
constant: false
boundary condition: true
is: SBO:0000252

metaM trp L e
boundary condition: false
notes: FORMULA: C11H12N2O2 CHARGE: 0 INCHI: InChI=1S/C11H12N2O2/c12-9(11(14)15)5-7-6-13-10-4-2-1-3-8(7)10/h1-4,6,9,13H,5,12H2,(H,14,15)/t9-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00080
has only substance units: false
type: Species
initial concentration: 1.0
is: HMDB00929
name: L-tryptophan
is: SBO:0000247
initial amount: NaN
is: CHEBI:16828
constant: false

http://identifiers.org/biomodels.db/MODEL1310110045#_57826331_7346_4ec2_acb2_68e85d09335f
type: Species
has only substance units: false
name: LDHC
is: SBO:0000252
is encoded by: hsa:3948
constant: false
initial concentration: NaN
boundary condition: true
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110045#_1106d022_7d2a_4b75_a7c9_58da2a44c9f0
has only substance units: false
is: P17812
boundary condition: true
is encoded by: hsa:1503
name: CTPS1
is: SBO:0000252
type: Species
constant: false
initial amount: NaN
initial concentration: NaN

metaM xan c
name: Xanthine
boundary condition: false
initial amount: NaN
notes: FORMULA: C5H4N4O2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00320 EHMN_ABBREVIATION: C00385
is: HMDB00292
type: Species
constant: false
initial concentration: 1.0
is: C00385
is: SBO:0000247
has only substance units: false
is: CHEBI:17712

metaR TDCHOLAte
type: Reaction
reactant: MODEL1310110045#
kinetic law: MODEL1310110045#
reversible: true
product: MODEL1310110045#
name: bile acid intracellular transport
is described by: ECO:0000000
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:unknown mechanism, however bile acids need to be secreted out of the cell NJ
fast: false

http://identifiers.org/biomodels.db/MODEL1310110045#_793fa870_ce99_4b95_a456_db4e6701995f
name: EBP
initial concentration: NaN
boundary condition: true
is encoded by: hsa:10682
has only substance units: false
is: SBO:0000252
initial amount: NaN
type: Species
is: Q15125
constant: false

metaM fprica c
is: C04734
notes: FORMULA: C10H13N4O9P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC01344 EHMN_ABBREVIATION: C04734
is: CHEBI:58467
initial amount: NaN
name: 5-Formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide
has only substance units: false
initial concentration: 1.0
boundary condition: false
is: SBO:0000247
is: HMDB01439
type: Species
constant: false

http://identifiers.org/biomodels.db/MODEL1310110045#_8d61c334_a0b5_44eb_825e_47047067bb6c
initial amount: NaN
boundary condition: true
type: Species
is: SBO:0000252
name: NDUFA7
has only substance units: false
is encoded by: hsa:4701
is: Q6FG42
initial concentration: NaN
constant: false

metaM ump e
is: CHEBI:57865
constant: false
is: SBO:0000247
is: HMDB00288
type: Species
name: UMP(2-)
initial concentration: 1.0
notes: FORMULA: C9H11N2O9P CHARGE: -2 INCHI: InChI=1S/C9H13N2O9P/c12-5-1-2-11(9(15)10-5)8-7(14)6(13)4(20-8)3-19-21(16,17)18/h1-2,4,6-8,13-14H,3H2,(H,10,12,15)(H2,16,17,18)/p-2/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00105 EHMN_ABBREVIATION: C00105
boundary condition: false
has only substance units: false
initial amount: NaN

metaM succ m
is: HMDB00254
name: Succinate
notes: FORMULA: C4H4O4 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00049 EHMN_ABBREVIATION: C00042
is: CHEBI:30031
boundary condition: false
constant: false
type: Species
is: SBO:0000247
initial concentration: 1.0
is: C00042
initial amount: NaN
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110045#_2fad17a9_c29d_46e0_b260_c9d83bedcf35
initial amount: NaN
name: ACAD9
type: Species
is: SBO:0000252
is: Q9H845
has only substance units: false
is encoded by: hsa:28976
boundary condition: true
initial concentration: NaN
constant: false

http://identifiers.org/biomodels.db/MODEL1310110045#_19460325_8929_4fff_b981_5fdf4c3538b7
constant: false
has only substance units: false
type: Species
boundary condition: true
initial concentration: NaN
is encoded by: hsa:23539
name: SLC16A8
initial amount: NaN
is: O95907
is: SBO:0000252

metaR NAHCO3 HCLt
reversible: true
is: SBO:0000185
reactant: MODEL1310110045#
type: Reaction
fast: false
notes: GENE_ASSOCIATION: (9498.1) or (57282.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14722772 NOTES:MM
product: MODEL1310110045#
name: bicarbonate transport (HCl/NaHCO3 exchange)
kinetic law: MODEL1310110045#
is described by: ECO:0000269
modifier: MODEL1310110045#

metaR CDPDAGtm
is described by: ECO:0000000
fast: false
is: SBO:0000185
kinetic law: MODEL1310110045#
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 1 AUTHORS: NOTES:unknown mechanism, presumed diffusion NJ
reactant: MODEL1310110045#
name: intracellular transport
product: MODEL1310110045#
type: Reaction

metaR r1561
is: SBO:0000185
reactant: MODEL1310110045#
fast: false
reversible: true
product: MODEL1310110045#
type: Reaction
kinetic law: MODEL1310110045#
is described by: ECO:0000000
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110045#_8978c1e6_3cd6_40ff_a040_eee9acc8d0cd
constant: false
name: _AA278423_1_m
has only substance units: false
is: SBO:0000252
is encoded by: hsa:AA278423
initial amount: NaN
type: Species
boundary condition: true
initial concentration: NaN

metaM creat c
notes: FORMULA: C4H9N3O2 CHARGE: 0 INCHI: InChI=1S/C4H9N3O2/c1-7(4(5)6)2-3(8)9/h2H2,1H3,(H3,5,6)(H,8,9) HEPATONET_1.0_ABBREVIATION: HC00260 EHMN_ABBREVIATION: C00300
initial concentration: 1.0
is: CHEBI:16919
constant: false
has only substance units: false
boundary condition: false
name: creatine
is: SBO:0000247
type: Species
is: HMDB00064
initial amount: NaN

metaM mlthf c
name: 5,10-Methylenetetrahydrofolate
type: Species
initial amount: NaN
has only substance units: false
is: HMDB01533
notes: FORMULA: C20H21N7O6 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00140 EHMN_ABBREVIATION: C00143
is: SBO:0000247
is: CHEBI:15636
initial concentration: 1.0
boundary condition: false
is: C00143
constant: false

metaR r1787
type: Reaction
kinetic law: MODEL1310110045#
reactant: MODEL1310110045#
name: Y+LAT2 Utilized transport
product: MODEL1310110045#
fast: false
is: SBO:0000185
modifier: MODEL1310110045#
reversible: false
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is described by: ECO:0000000

metaR ECOAH9m
reversible: true
type: Reaction
product: MODEL1310110045#
is version of: http://identifiers.org/ec-code/2.3.1.16
is: SBO:0000176
is version of: http://identifiers.org/ec-code/4.2.1.17
modifier: MODEL1310110045#
is described by: ECO:0000304
name: 2-Methylprop-2-enoyl-CoA (2-Methylbut-2-enoyl-CoA), mitochondrial
kinetic law: MODEL1310110045#
notes: GENE_ASSOCIATION: (1892.1) or (3030.1) and (3032.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 4.2.1.17 Confidence Level: 2 AUTHORS: PMID:9073515 NOTES:MM. based on assigned short chain enoyl-CoA hydratase activity
reactant: MODEL1310110045#
fast: false

metaR r2083
is described by: ECO:0000000
modifier: MODEL1310110045#
is: SBO:0000185
type: Reaction
kinetic law: MODEL1310110045#
fast: false
reversible: true
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
product: MODEL1310110045#
reactant: MODEL1310110045#

metaM so4 m
notes: FORMULA: O4S CHARGE: -2 INCHI: InChI=1S/H2O4S/c1-5(2,3)4/h(H2,1,2,3,4)/p-2 HEPATONET_1.0_ABBREVIATION: HC00062 EHMN_ABBREVIATION: C00059
is: SBO:0000247
initial amount: NaN
boundary condition: false
has only substance units: false
initial concentration: 1.0
is: CHEBI:16189
type: Species
name: sulfate
is: HMDB01448
constant: false

metaR r1560
is: SBO:0000185
is described by: ECO:0000000
reactant: MODEL1310110045#
fast: false
product: MODEL1310110045#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
kinetic law: MODEL1310110045#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reversible: true
type: Reaction

metaM n4m2masn g
notes: FORMULA: C66H109N6O45X CHARGE: 0
constant: false
is: SBO:0000247
is: C05881
boundary condition: false
name: ((N-acetyl-D-glucosaminyl)4-(alpha-D-mannosyl)2-beta-D-mannosyl-diacetylchitobiosyl)-L-asparagine (protein)
initial concentration: 1.0
type: Species
initial amount: NaN
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110045#_a2a12b87_dec3_4ef2_99f2_528b47a9f187
boundary condition: true
is encoded by: hsa:10846
type: Species
initial amount: NaN
is: SBO:0000252
is: Q9Y233
has only substance units: false
constant: false
initial concentration: NaN
name: PDE10A

metaM dctp n
is: CHEBI:16311
has only substance units: false
initial concentration: 1.0
initial amount: NaN
type: Species
is: HMDB00998
name: dCTP
is: C00458
boundary condition: false
notes: FORMULA: C9H12N3O13P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00367 EHMN_ABBREVIATION: C00458
constant: false
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110045#_d4b10124_33fe_4dfc_aee3_3471e24d2126
initial concentration: NaN
initial amount: NaN
type: Species
is: SBO:0000252
constant: false
is: P39656
is encoded by: hsa:1650
has only substance units: false
name: DDOST
boundary condition: true

metaM ca2 e
is: CHEBI:29108
is: HMDB00464
name: calcium(2+)
initial concentration: 1.0
is: SBO:0000247
initial amount: NaN
boundary condition: false
has only substance units: false
notes: FORMULA: Ca CHARGE: 2 INCHI: InChI=1S/Ca/q+2 EHMN_ABBREVIATION: C00076
type: Species
constant: false

metaM but c
type: Species
is: SBO:0000247
has only substance units: false
name: butyrate
boundary condition: false
notes: FORMULA: C4H7O2 CHARGE: -1 INCHI: InChI=1S/C4H8O2/c1-2-3-4(5)6/h2-3H2,1H3,(H,5,6)/p-1 HEPATONET_1.0_ABBREVIATION: HC00223 EHMN_ABBREVIATION: C00246
is: CHEBI:17968
constant: false
initial concentration: 1.0
initial amount: NaN
is: HMDB00039

metaR r2084
fast: false
kinetic law: MODEL1310110045#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
type: Reaction
modifier: MODEL1310110045#
reactant: MODEL1310110045#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
product: MODEL1310110045#
reversible: true
is: SBO:0000185

metaM so4 l
notes: FORMULA: O4S CHARGE: -2 INCHI: InChI=1S/H2O4S/c1-5(2,3)4/h(H2,1,2,3,4)/p-2 HEPATONET_1.0_ABBREVIATION: HC00062 EHMN_ABBREVIATION: C00059
name: sulfate
is: HMDB01448
constant: false
is: CHEBI:16189
boundary condition: false
initial concentration: 1.0
is: SBO:0000247
has only substance units: false
initial amount: NaN
type: Species

metaR PRFGS
name: phosphoribosylformylglycinamidine synthase
reactant: MODEL1310110045#
kinetic law: MODEL1310110045#
is described by: ECO:0000269
modifier: MODEL1310110045#
reversible: false
is: SBO:0000176
type: Reaction
is version of: http://identifiers.org/ec-code/6.3.5.3
product: MODEL1310110045#
fast: false
notes: GENE_ASSOCIATION: (5198.1) SUBSYSTEM: Purine synthesis EC Number: Confidence Level: 4 AUTHORS: NOTES:

metaM dcyt n
is: HMDB00014
notes: FORMULA: C9H13N3O4 CHARGE: 0 INCHI: InChI=1S/C9H13N3O4/c10-7-1-2-12(9(15)11-7)8-3-5(14)6(4-13)16-8/h1-2,5-6,8,13-14H,3-4H2,(H2,10,11,15)/t5-,6+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00574 EHMN_ABBREVIATION: C00881
constant: false
type: Species
initial amount: NaN
initial concentration: 1.0
is: CHEBI:15698
name: 2'-deoxycytidine
boundary condition: false
has only substance units: false
is: SBO:0000247

metaR r0287
is described by: ECO:0000000
kinetic law: MODEL1310110045#
type: Reaction
fast: false
notes: GENE_ASSOCIATION: (6576.1) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.16 Confidence Level: 0 AUTHORS: PMID:10806397,PMID:1121274,PMID:1679347,PMID:1735445,PMID:1979337,PMID:2048733,PMID:3194209,PMID:6378901,PMID:8241273 NOTES:
product: MODEL1310110045#
modifier: MODEL1310110045#
reversible: false
reactant: MODEL1310110045#
name: Acetyl-CoA:acetyl-CoA C-acetyltransferase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:2.3.1.16
is: SBO:0000176

metaR OCDCAtr
fast: false
product: MODEL1310110045#
name: fatty acid transport via diffusion
reversible: true
is described by: ECO:0000000
reactant: MODEL1310110045#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11788354,PMID:12864740 NOTES:NJ
is: SBO:0000185
kinetic law: MODEL1310110045#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110045#_9eff5abf_8b6e_4388_b9b8_7100972fd473
name: CAD
constant: false
initial concentration: NaN
is: SBO:0000252
boundary condition: true
initial amount: NaN
is: P27708
is encoded by: hsa:790
has only substance units: false
type: Species

metaM creat e
boundary condition: false
has only substance units: false
is: CHEBI:16919
type: Species
initial concentration: 1.0
constant: false
name: creatine
initial amount: NaN
notes: FORMULA: C4H9N3O2 CHARGE: 0 INCHI: InChI=1S/C4H9N3O2/c1-7(4(5)6)2-3(8)9/h2H2,1H3,(H3,5,6)(H,8,9) HEPATONET_1.0_ABBREVIATION: HC00260 EHMN_ABBREVIATION: C00300
is: HMDB00064
is: SBO:0000247

metaR EX gtp LPAREN e RPAREN
kinetic law: MODEL1310110045#
reactant: MODEL1310110045#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: GTP exchange
type: Reaction

metaR LEUKTRB4t
type: Reaction
is described by: ECO:0000000
reactant: MODEL1310110045#
kinetic law: MODEL1310110045#
fast: false
product: MODEL1310110045#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:
is: SBO:0000185
name: leukotriene B4 transport
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110045#_375d4b72_7dce_49a4_9842_4295d1db986a
boundary condition: true
has only substance units: false
name: CA12
is: SBO:0000252
is encoded by: hsa:771
initial concentration: NaN
constant: false
type: Species
is: O43570
initial amount: NaN

metaR r2081
reactant: MODEL1310110045#
kinetic law: MODEL1310110045#
product: MODEL1310110045#
is described by: ECO:0000000
is: SBO:0000185
modifier: MODEL1310110045#
type: Reaction
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
reversible: true
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
fast: false

http://identifiers.org/biomodels.db/MODEL1310110045#_f01ac8fb_1e71_40b5_9fea_e6d55b800208
boundary condition: true
is: B7Z763
type: Species
is: SBO:0000252
initial concentration: NaN
is encoded by: hsa:272
name: AMPD3
initial amount: NaN
has only substance units: false
constant: false

metaM e4hglu m
is: CHEBI:6331
initial amount: NaN
initial concentration: 1.0
constant: false
has only substance units: false
type: Species
notes: FORMULA: C5H8NO5 CHARGE: -1 INCHI: InChI=1S/C5H9NO5/c6-2(4(8)9)1-3(7)5(10)11/h2-3,7H,1,6H2,(H,8,9)(H,10,11)/p-1/t2-,3+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01663 EHMN_ABBREVIATION: C05947
is: SBO:0000247
boundary condition: false
name: erythro-4-hydroxy-L-glutamate(1-)
is: HMDB02273

http://identifiers.org/biomodels.db/MODEL1310110045#_3cef431d_c317_418e_9497_ff93f92c7f0c
type: Species
initial concentration: NaN
name: SLC24A1
is: SBO:0000252
constant: false
is encoded by: hsa:9187
is: B4DUG1
boundary condition: true
initial amount: NaN
has only substance units: false

metaM sphmyln hs c
has only substance units: false
initial amount: NaN
notes: FORMULA: CHARGE: 0
is: HMDB00156
is: SBO:0000247
type: Species
name: sphmyln_hs[c]
constant: false
is: CHEBI:15589
initial concentration: 1.0
boundary condition: false

metaM ksi pre17 g
initial concentration: 1.0
has only substance units: false
is: CHEBI:28067
constant: false
initial amount: NaN
type: Species
boundary condition: false
notes: FORMULA: C157H252N11O127S5X CHARGE: -6
name: keratan sulfate I biosynthesis, precursor 17
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110045#_2db3799c_3591_44e7_9890_25cf176de9cf
has only substance units: false
constant: false
is encoded by: hsa:5295
is: B3KT19
is: SBO:0000252
name: PIK3R1
initial amount: NaN
boundary condition: true
initial concentration: NaN
type: Species

http://identifiers.org/biomodels.db/MODEL1310110045#_74f97dfa_1ad6_4ee8_bffd_53d0113afff4
initial concentration: NaN
name: _AI824319_1_r
has only substance units: false
constant: false
boundary condition: true
initial amount: NaN
is: SBO:0000252
type: Species
is encoded by: hsa:AI824319

metaM ksii core2 pre2 g
constant: false
is: CHEBI:58053
boundary condition: false
name: keratan sulfate II biosynthesis, precursor 2
has only substance units: false
initial amount: NaN
initial concentration: 1.0
is: HMDB00175
type: Species
notes: FORMULA: C39H63N3O28X CHARGE: -1
is: C00130
is: SBO:0000247

metaR FAOXC10C8x
kinetic law: MODEL1310110045#
product: MODEL1310110045#
reactant: MODEL1310110045#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C10-->C8)x
type: Reaction

metaR r2082
kinetic law: MODEL1310110045#
fast: false
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
modifier: MODEL1310110045#
is described by: ECO:0000000
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
type: Reaction
product: MODEL1310110045#
reversible: true
reactant: MODEL1310110045#
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110045#_b0fb7681_b288_4ec6_8544_2a45b5ae95a1
has only substance units: false
type: Species
is encoded by: hsa:123041
is: Q8NFF2
constant: false
initial amount: NaN
initial concentration: NaN
name: SLC24A4
boundary condition: true
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110045#_a8556593_f553_44ed_823a_ad0817960e67
type: Species
boundary condition: true
name: PLCH1
has only substance units: false
is: SBO:0000252
constant: false
initial concentration: NaN
initial amount: NaN
is: Q4KWH8
is encoded by: hsa:23007

http://identifiers.org/biomodels.db/MODEL1310110045#_340585ff_9ba6_4cbd_b49b_b5afd4139371
initial concentration: NaN
constant: false
has only substance units: false
is: E7EML0
is encoded by: hsa:9498
initial amount: NaN
type: Species
is: SBO:0000252
name: SLC4A8
boundary condition: true

metaR r1565
reversible: true
reactant: MODEL1310110045#
product: MODEL1310110045#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is described by: ECO:0000000
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
fast: false
kinetic law: MODEL1310110045#
is: SBO:0000185

metaR ACt2m
kinetic law: MODEL1310110045#
reactant: MODEL1310110045#
type: Reaction
name: acetate mitochondrial transport via proton symport
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: PMID:10198029,PMID:15755952 NOTES:NCD
is described by: ECO:0000000
fast: false
is: SBO:0000185
product: MODEL1310110045#

metaR PItx
name: Phosphate transporter, peroxisome
is described by: ECO:0000000
reactant: MODEL1310110045#
product: MODEL1310110045#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 1 AUTHORS: NOTES:diffusion NJ
is: SBO:0000185
type: Reaction
kinetic law: MODEL1310110045#
reversible: true
fast: false

http://identifiers.org/biomodels.db/MODEL1310110045#_df4bf8aa_5115_45eb_9f24_93692c9242e8
type: Species
is: SBO:0000252
initial amount: NaN
boundary condition: true
has only substance units: false
is encoded by: hsa:112
initial concentration: NaN
name: ADCY6
constant: false

metaM o2s e
is: SBO:0000247
is: HMDB02168
type: Species
is: CHEBI:18421
name: superoxide
initial concentration: 1.0
notes: FORMULA: O2 CHARGE: -1 INCHI: InChI=1S/HO2/c1-2/h1H/p-1 HEPATONET_1.0_ABBREVIATION: HC00505 EHMN_ABBREVIATION: C00704
initial amount: NaN
has only substance units: false
constant: false
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110045#_7424e0bc_7174_4b5e_b843_b0dc8a53656f
boundary condition: true
type: Species
is encoded by: hsa:501
name: ALDH7A1
initial amount: NaN
is: SBO:0000252
has only substance units: false
initial concentration: NaN
constant: false
is: E7EPT3

metaR FATP7t
notes: GENE_ASSOCIATION: (10998.1) or (11001.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10479480,PMID:12856180,PMID:15522816 NOTES:electroneutral transport NJ
type: Reaction
modifier: MODEL1310110045#
is version of: http://identifiers.org/ec-code/6.2.1.3
kinetic law: MODEL1310110045#
reactant: MODEL1310110045#
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/6.2.1.7
product: MODEL1310110045#
name: fatty acid electroneutral transport
reversible: true
fast: false
is: SBO:0000185

metaR EX gmp LPAREN e RPAREN
kinetic law: MODEL1310110045#
reactant: MODEL1310110045#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: GMP exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110045#_9b82c0a5_1344_4de5_a261_a9c8e98fe295
initial concentration: NaN
is: Q9ULD0
boundary condition: true
has only substance units: false
initial amount: NaN
type: Species
is encoded by: hsa:55753
name: OGDHL
is: SBO:0000252
constant: false

http://identifiers.org/biomodels.db/MODEL1310110045#_8491ce53_3ffe_4a50_bd3a_11a72a2c2326
initial concentration: NaN
constant: false
has only substance units: false
is encoded by: hsa:4711
is: O43674
is: SBO:0000252
type: Species
boundary condition: true
name: NDUFB5
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110045#_5a64ff43_9c39_453c_a141_9041220d74f1
boundary condition: true
type: Species
initial amount: NaN
constant: false
has only substance units: false
is encoded by: hsa:195814
is: SBO:0000252
initial concentration: NaN
is: B3KT84
name: SDR16C5

http://identifiers.org/biomodels.db/MODEL1310110045#_40ab257c_3864_4894_bd50_39bd9b620bc2
is: SBO:0000252
is: Q16762
is encoded by: hsa:7263
constant: false
boundary condition: true
type: Species
has only substance units: false
initial amount: NaN
initial concentration: NaN
name: TST

metaM ksi deg27 l
is: SBO:0000247
type: Species
initial amount: NaN
name: keratan sulfate I, degradation product 27
is: HMDB00143
is: CHEBI:12936
has only substance units: false
constant: false
notes: FORMULA: C104H169N7O88S4 CHARGE: -4
initial concentration: 1.0
boundary condition: false

metaM m7masnB g
initial amount: NaN
name: (alpha-D-mannosyl)7-beta-D-mannosyl-diacetylchitobiosyl-L-asparagine, isoform B (protein)
type: Species
is: C05881
has only substance units: false
boundary condition: false
initial concentration: 1.0
notes: FORMULA: C64H107N2O50X CHARGE: 0
is: SBO:0000247
constant: false

metaR G14T20g
type: Reaction
modifier: MODEL1310110045#
reactant: MODEL1310110045#
is version of: http://identifiers.org/ec-code/2.4.1.38
product: MODEL1310110045#
reversible: false
name: beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase, Golgi
is: SBO:0000176
is described by: ECO:0000000
fast: false
kinetic law: MODEL1310110045#
is version of: http://identifiers.org/ec-code/2.4.1.22
is version of: http://identifiers.org/ec-code/2.4.1.90
notes: GENE_ASSOCIATION: (8703.1) or (2683.1) or (8704.2) or (8704.1) or (9334.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.38 Confidence Level: 4 AUTHORS: PMID:10747980,PMID:12512857,PMID:1903938,PMID:3094506,PMID:3144273,PMID:9405390,PMID:9435216 NOTES:Keratan sulfate II biosynthesis NCD

metaR r1564
product: MODEL1310110045#
reversible: true
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
fast: false
kinetic law: MODEL1310110045#
is: SBO:0000185
type: Reaction
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reactant: MODEL1310110045#

metaM ksi pre1 g
is: HMDB00175
type: Species
has only substance units: false
is: CHEBI:58053
name: keratan sulfate I biosynthesis, precursor 1
initial concentration: 1.0
boundary condition: false
constant: false
notes: FORMULA: C79H129N5O57X CHARGE: -1
is: C00130
initial amount: NaN
is: SBO:0000247

metaM xol7aone r
is: CHEBI:17899
type: Species
notes: FORMULA: C27H44O2 CHARGE: 0 INCHI: InChI=1S/C27H44O2/c1-17(2)7-6-8-18(3)21-9-10-22-25-23(12-14-27(21,22)5)26(4)13-11-20(28)15-19(26)16-24(25)29/h15,17-18,21-25,29H,6-14,16H2,1-5H3/t18-,21-,22+,23+,24-,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01464 EHMN_ABBREVIATION: C05455
is: HMDB01993
is: SBO:0000247
constant: false
has only substance units: false
initial amount: NaN
name: 7alpha-hydroxycholest-4-en-3-one
boundary condition: false
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110045#_cd99fa7b_9dc8_4354_8d85_9e428967f6e2
is encoded by: hsa:80025
name: PANK2
has only substance units: false
is: SBO:0000252
type: Species
constant: false
initial amount: NaN
boundary condition: true
initial concentration: NaN

metaR r2080
reversible: true
kinetic law: MODEL1310110045#
is: SBO:0000185
is described by: ECO:0000000
type: Reaction
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
reactant: MODEL1310110045#
fast: false
product: MODEL1310110045#
modifier: MODEL1310110045#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1

http://identifiers.org/biomodels.db/MODEL1310110045#_76de5840_563c_454e_adb1_ae2387243848
constant: false
is: Q59FD4
is: SBO:0000252
is encoded by: hsa:3098
has only substance units: false
boundary condition: true
name: HK1
initial concentration: NaN
initial amount: NaN
type: Species

http://identifiers.org/biomodels.db/MODEL1310110045#_36210784_09bc_4ef5_9f23_400d20f96750
constant: false
type: Species
boundary condition: true
has only substance units: false
initial concentration: NaN
name: SLC35A1
initial amount: NaN
is encoded by: hsa:10559
is: P78382
is: SBO:0000252

metaR r0913
is described by: ECO:0000000
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
reactant: MODEL1310110045#
product: MODEL1310110045#
fast: false
type: Reaction
kinetic law: MODEL1310110045#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:16919238,PMID:17173541,PMID:18406340,PMID:8132483 NOTES:
is: SBO:0000185
reversible: true

metaM udpglcur r
is: C00167
is: CHEBI:58052
boundary condition: false
initial amount: NaN
initial concentration: 1.0
has only substance units: false
notes: FORMULA: C15H19N2O18P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00162 EHMN_ABBREVIATION: C00167
constant: false
is: SBO:0000247
type: Species
is: HMDB00935
name: UDP-D-glucuronate

metaR AMPDA
fast: false
type: Reaction
modifier: MODEL1310110045#
notes: GENE_ASSOCIATION: (271.2) or (270.1) or (271.1) or (272.1) or (271.3) SUBSYSTEM: Nucleotide interconversion EC Number: 3.5.4.6 Confidence Level: 4 AUTHORS: PMID:1400401,PMID:2345176 NOTES:
reactant: MODEL1310110045#
name: Adenosine monophosphate deaminase
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/3.5.4.6
reversible: false
product: MODEL1310110045#
kinetic law: MODEL1310110045#
is: SBO:0000176

metaM glyc c
boundary condition: false
is: HMDB00131
has only substance units: false
initial amount: NaN
is: C00116
is: CHEBI:17754
is: SBO:0000247
notes: FORMULA: C3H8O3 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00114 EHMN_ABBREVIATION: C00116
name: Glycerol
initial concentration: 1.0
constant: false
type: Species

metaR NRVNCCOAtx
is: SBO:0000185
is described by: ECO:0000000
kinetic law: MODEL1310110045#
reversible: true
type: Reaction
reactant: MODEL1310110045#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: NOTES:interaction between peroxisomes and ER (some enzymes on the outer membrane) NJ
name: fatty acid intracellular transport
fast: false
product: MODEL1310110045#

metaR r1563
reversible: true
is: SBO:0000185
product: MODEL1310110045#
reactant: MODEL1310110045#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
kinetic law: MODEL1310110045#
type: Reaction
fast: false
is described by: ECO:0000000

metaR G14Tg
name: beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase
is described by: ECO:0000269
modifier: MODEL1310110045#
type: Reaction
is version of: http://identifiers.org/ec-code/2.4.1.38
kinetic law: MODEL1310110045#
fast: false
is: SBO:0000176
notes: GENE_ASSOCIATION: (9334.1) or (2683.1) or (8704.1) or (8703.1) or (8704.2) SUBSYSTEM: N-glycan synthesis EC Number: 2.4.1.38 Confidence Level: 4 AUTHORS: PMID:9597550 NOTES:NCD
is version of: http://identifiers.org/ec-code/2.4.1.22
product: MODEL1310110045#
reactant: MODEL1310110045#
reversible: false
is version of: http://identifiers.org/ec-code/2.4.1.90

http://identifiers.org/biomodels.db/MODEL1310110045#_e98e4543_3855_463e_8f8d_c7e5d8833c48
type: Species
initial concentration: NaN
is: Q5VYT2
boundary condition: true
is: SBO:0000252
name: NDUFB6
constant: false
is encoded by: hsa:4712
initial amount: NaN
has only substance units: false

metaR HYXNt
kinetic law: MODEL1310110045#
fast: false
modifier: MODEL1310110045#
type: Reaction
notes: GENE_ASSOCIATION: (3177.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12006583,PMID:12838422 NOTES:tv
is described by: ECO:0000269
product: MODEL1310110045#
reactant: MODEL1310110045#
name: Hypoxanthine transport
is: SBO:0000185
reversible: true

metaR r0170
kinetic law: MODEL1310110045#
reactant: MODEL1310110045#
notes: GENE_ASSOCIATION: (H77542.1) or (5313.1) or (5315.1) SUBSYSTEM: Cholesterol metabolism EC Number: 2.5.1.21 Confidence Level: 0 AUTHORS: PMID:11108725,PMID:1527001,PMID:17180682,PMID:7864626,PMID:8509416 NOTES:
reversible: true
fast: false
is version of: http://identifiers.org/ec-code/2.7.1.40
is: SBO:0000176
is described by: ECO:0000000
product: MODEL1310110045#
name: Farnesyl-diphosphate:farnesyl-diphosphate farnesyltransferase Biosynthesis of steroids EC:2.5.1.21
modifier: MODEL1310110045#
type: Reaction

metaM fum c
has only substance units: false
is: C00122
is: SBO:0000247
notes: FORMULA: C4H2O4 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00120 EHMN_ABBREVIATION: C00122
initial concentration: 1.0
name: Fumarate
constant: false
is: CHEBI:29806
initial amount: NaN
type: Species
boundary condition: false
is: HMDB00134

http://identifiers.org/biomodels.db/MODEL1310110045#_68cdfbdf_94da_4d54_8bf7_e1b28ba3a06f
name: PIP4K2C
is: B3KQV3
has only substance units: false
initial amount: NaN
initial concentration: NaN
type: Species
is encoded by: hsa:79837
constant: false
is: SBO:0000252
boundary condition: true

metaM o2s c
name: superoxide
is: SBO:0000247
type: Species
notes: FORMULA: O2 CHARGE: -1 INCHI: InChI=1S/HO2/c1-2/h1H/p-1 HEPATONET_1.0_ABBREVIATION: HC00505 EHMN_ABBREVIATION: C00704
is: HMDB02168
initial concentration: 1.0
is: CHEBI:18421
has only substance units: false
initial amount: NaN
boundary condition: false
constant: false

http://identifiers.org/biomodels.db/MODEL1310110045#_a0ff88c8_d4ab_402e_b2e5_2717a9c50b82
initial concentration: NaN
initial amount: NaN
name: NIT2
constant: false
is encoded by: hsa:56954
has only substance units: false
boundary condition: true
is: SBO:0000252
type: Species
is: Q9NQR4

metaR HACD1m
is version of: http://identifiers.org/ec-code/2.3.1.16
is described by: ECO:0000134
notes: GENE_ASSOCIATION: (3028.1) or (3033.1) or (3030.1) and (3032.1) SUBSYSTEM: Tryptophan metabolism EC Number: 1.1.1.35 Confidence Level: 1 AUTHORS: PMID:17143551,PMID:17143552 NOTES:Same as EC 1.1.1.157 SAB mito. some physiological
is: SBO:0000176
product: MODEL1310110045#
is version of: http://identifiers.org/ec-code/1.1.1.35
modifier: MODEL1310110045#
name: 3-hydroxyacyl-CoA dehydrogenase (acetoacetyl-CoA) (mitochondria)
fast: false
reactant: MODEL1310110045#
reversible: true
is version of: http://identifiers.org/ec-code/4.2.1.17
kinetic law: MODEL1310110045#
type: Reaction

metaR DESAT22 2p
reactant: MODEL1310110045#
fast: false
product: MODEL1310110045#
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid synthesis EC Number: 1.14.19.1 Confidence Level: 4 AUTHORS: NOTES:
is described by: ECO:0000000
kinetic law: MODEL1310110045#
reversible: false
type: Reaction
is: SBO:0000176
name: fatty acyl-CoA desaturase (n-C22:5CoA -> n-C22:6CoA)

metaR r1562
product: MODEL1310110045#
is described by: ECO:0000000
reactant: MODEL1310110045#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reversible: true
kinetic law: MODEL1310110045#
fast: false
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110045#_ac441d0a_87bf_4c43_a4a2_a814b641e378
constant: false
has only substance units: false
is: SBO:0000252
is encoded by: hsa:6120
initial concentration: NaN
is: Q53TV9
boundary condition: true
name: RPE
initial amount: NaN
type: Species

metaM glc D r
has only substance units: false
is: SBO:0000247
initial amount: NaN
type: Species
is: CHEBI:4167
constant: false
initial concentration: 1.0
is: HMDB00122
notes: FORMULA: C6H12O6 CHARGE: 0 INCHI: InChI=1S/C6H12O6/c7-1-2-3(8)4(9)5(10)6(11)12-2/h2-11H,1H2/t2-,3-,4+,5-,6?/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00040
name: D-glucose
boundary condition: false

metaM 3hexdtricoa m
initial amount: NaN
notes: FORMULA: C37H56N7O17P3S CHARGE: -4
name: 3,7,10-hexadecatrienoylcoa
type: Species
is: SBO:0000247
is: HMDB02288
initial concentration: 1.0
boundary condition: false
has only substance units: false
constant: false

metaM h c
has only substance units: false
boundary condition: false
is: SBO:0000247
notes: FORMULA: H CHARGE: 1 INCHI: "
initial concentration: 1.0
initial amount: NaN
name: proton
is: CHEBI:24636
constant: false
type: Species
is: http://identifiers.org/pubchem.compound/3380
is: C00080

metaR GTHRDt
reversible: true
name: Glutathione transport into mitochondria
kinetic law: MODEL1310110045#
product: MODEL1310110045#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Glutathione metabolism EC Number: Confidence Level: 2 AUTHORS: NOTES:TV (8-15-2003) Meister, A, Mitochondrial changes associated with glutathione deficiency, Biochimica et Biophysica Acta 1271 (1995) 35-42. The article reports that this is an active transport but doesn't not specify if it uses atp.
reactant: MODEL1310110045#
fast: false
is described by: ECO:0000000
type: Reaction

metaR EX prostge2 LPAREN e RPAREN
kinetic law: MODEL1310110045#
reactant: MODEL1310110045#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Prostaglandin E2 exchange
type: Reaction

metaM hLkynr c
is: SBO:0000247
type: Species
has only substance units: false
constant: false
boundary condition: false
initial amount: NaN
name: 3-hydroxy-L-kynurenine
is: HMDB11631
notes: FORMULA: C10H12N2O4 CHARGE: 0 INCHI: InChI=1S/C10H12N2O4/c11-6(10(15)16)4-8(14)5-2-1-3-7(13)9(5)12/h1-3,6,13H,4,11-12H2,(H,15,16)/t6-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01079 EHMN_ABBREVIATION: C03227
is: CHEBI:17380
initial concentration: 1.0

metaR r0911
product: MODEL1310110045#
is described by: ECO:0000000
fast: false
reactant: MODEL1310110045#
kinetic law: MODEL1310110045#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:11004451,PMID:8898903 NOTES:
type: Reaction
reversible: true
name: Facilitated diffusion
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110045#_ec4759b1_3dbf_4d31_af00_2fb4dc6913ce
initial amount: NaN
initial concentration: NaN
type: Species
constant: false
is encoded by: hsa:AI915649
boundary condition: true
has only substance units: false
is: SBO:0000252
name: _AI915649_1_c

metaM glyc e
initial amount: NaN
boundary condition: false
is: C00116
has only substance units: false
is: SBO:0000247
is: CHEBI:17754
notes: FORMULA: C3H8O3 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00114 EHMN_ABBREVIATION: C00116
constant: false
name: Glycerol
initial concentration: 1.0
is: HMDB00131
type: Species

metaR r1788
reactant: MODEL1310110045#
is: SBO:0000185
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is described by: ECO:0000000
fast: false
product: MODEL1310110045#
reversible: false
type: Reaction
name: Y+LAT2 Utilized transport
kinetic law: MODEL1310110045#
modifier: MODEL1310110045#

http://identifiers.org/biomodels.db/MODEL1310110045#_b74f0548_a743_4a36_bcc8_f8622562dbad
has only substance units: false
is encoded by: hsa:AI024818
constant: false
initial concentration: NaN
boundary condition: true
name: _AI024818_1_c
type: Species
is: SBO:0000252
initial amount: NaN

metaM m5mpdol L r
initial amount: NaN
name: (alpha-D-Mannosyl)5-beta-D-mannosyl-diacetylchitobiosyldiphosphodolichol, human liver homolog
constant: false
type: Species
has only substance units: false
is: CHEBI:37634
initial concentration: 1.0
notes: FORMULA: C1600H2628N20O470P20 CHARGE: -20
is: SBO:0000247
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110045#_5784c2d4_b7c8_4338_8c7c_fe8b9034951e
is encoded by: hsa:64077
boundary condition: true
has only substance units: false
initial amount: NaN
is: Q9H008
constant: false
is: SBO:0000252
name: LHPP
type: Species
initial concentration: NaN

metaR EX prostgi2 LPAREN e RPAREN
kinetic law: MODEL1310110045#
reactant: MODEL1310110045#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: prostaglandin I2(1-) exchange
type: Reaction

metaM HC01162 c
boundary condition: false
name: (2R,4S,5R,6R)-2-[({[(2R,3S,4R,5R)-5-(4-amino-2-oxo-1,2-dihydropyrimidin-1-yl)-3,4-dihydroxyoxolan-2-yl]methoxy}phosphinato)oxy]-4-hydroxy-5-(2-hydroxyacetamido)-6-[(1R,2R)-1,2,3-trihydroxypropyl]oxane-2-carboxylate
has only substance units: false
is: CHEBI:58376
is: SBO:0000247
notes: FORMULA: C20H29N4O17P CHARGE: -2 INCHI: InChI=1S/C20H31N4O17P/c21-10-1-2-24(19(35)22-10)17-15(32)14(31)9(39-17)6-38-42(36,37)41-20(18(33)34)3-7(27)12(23-11(29)5-26)16(40-20)13(30)8(28)4-25/h1-2,7-9,12-17,25-28,30-32H,3-6H2,(H,23,29)(H,33,34)(H,36,37)(H2,21,22,35)/p-2/t7-,8+,9+,12+,13+,14+,15+,16+,17+,20+/m0/s1 EHMN_ABBREVIATION: C03691
initial amount: NaN
constant: false
initial concentration: 1.0
type: Species

metaM dudp n
constant: false
initial concentration: 1.0
name: dUDP(3-)
notes: FORMULA: C9H11N2O11P2 CHARGE: -3 INCHI: InChI=1S/C9H14N2O11P2/c12-5-3-8(11-2-1-7(13)10-9(11)14)21-6(5)4-20-24(18,19)22-23(15,16)17/h1-2,5-6,8,12H,3-4H2,(H,18,19)(H,10,13,14)(H2,15,16,17)/p-3/t5-,6+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00768 EHMN_ABBREVIATION: C01346
is: CHEBI:60471
boundary condition: false
initial amount: NaN
is: HMDB01000
is: SBO:0000247
type: Species
has only substance units: false

metaR r1109
is: SBO:0000176
kinetic law: MODEL1310110045#
name: Citrate oxaloacetate-lyase ((pro-3S)-CH2COO- -->acetate) Citrate cycle (TCA cycle) EC:4.1.3.6
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 4.1.3.6 Confidence Level: 0 AUTHORS: PMID:11741334 NOTES:
is described by: ECO:0000000
type: Reaction
reversible: true
reactant: MODEL1310110045#
fast: false
product: MODEL1310110045#

metaR EX udp LPAREN e RPAREN
kinetic law: MODEL1310110045#
reactant: MODEL1310110045#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: UDP exchange
type: Reaction

metaM coa c
is: HMDB01423
constant: false
initial amount: NaN
notes: FORMULA: C21H32N7O16P3S CHARGE: -4
is: CHEBI:3312
name: Coenzyme A
initial concentration: 1.0
is: C00010
has only substance units: false
type: Species
is: SBO:0000247
boundary condition: false

metaR H2O2syn
is: SBO:0000176
is described by: ECO:0000304
type: Reaction
modifier: MODEL1310110045#
reversible: false
is version of: http://identifiers.org/ec-code/1.6.3.1
fast: false
name: Hydrogen peroxide synthesis (NADPH dependent)
product: MODEL1310110045#
reactant: MODEL1310110045#
notes: GENE_ASSOCIATION: (53905.1) or (50506.1) or (53905.2) SUBSYSTEM: Tyrosine metabolism EC Number: Confidence Level: 2 AUTHORS: PMID:15677770,PMID:15972824 NOTES:SAB lumped reaction--first O2 goes to superoxide radical, then dismutes to H2O2
kinetic law: MODEL1310110045#

metaR r0281
reversible: true
is version of: http://identifiers.org/ec-code/5.3.1.6
is described by: ECO:0000000
reactant: MODEL1310110045#
kinetic law: MODEL1310110045#
notes: GENE_ASSOCIATION: (22934.1) SUBSYSTEM: Methionine and cysteine metabolism EC Number: 1.4.3.6 Confidence Level: 0 AUTHORS: PMID:12072962,PMID:15795708,PMID:17006978,PMID:6403048 NOTES:
type: Reaction
modifier: MODEL1310110045#
fast: false
name: Putrescine:oxygen oxidoreductase (deaminating) Urea cycle and metabolism of amino groups EC:1.4.3.6
product: MODEL1310110045#
is: SBO:0000176

metaR r0917
is described by: ECO:0000000
product: MODEL1310110045#
type: Reaction
reversible: true
reactant: MODEL1310110045#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172 NOTES:
kinetic law: MODEL1310110045#
is: SBO:0000185
fast: false
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2

http://identifiers.org/biomodels.db/MODEL1310110045#_83ff7051_3f35_4fee_be88_f76fb84d1408
constant: false
is: SBO:0000252
type: Species
name: SLC7A9
has only substance units: false
is: P82251
initial amount: NaN
is encoded by: hsa:11136
boundary condition: true
initial concentration: NaN

metaM HC01403 m
notes: FORMULA: C31H50N7O18P3S CHARGE: -4 INCHI: InChI=1S/C31H54N7O18P3S/c1-4-5-6-7-8-9-19(39)14-22(41)60-13-12-33-21(40)10-11-34-29(44)26(43)31(2,3)16-53-59(50,51)56-58(48,49)52-15-20-25(55-57(45,46)47)24(42)30(54-20)38-18-37-23-27(32)35-17-36-28(23)38/h17-20,24-26,30,39,42-43H,4-16H2,1-3H3,(H,33,40)(H,34,44)(H,48,49)(H,50,51)(H2,32,35,36)(H2,45,46,47)/t19-,20+,24+,25+,26-,30+/m0/s1 EHMN_ABBREVIATION: C05264
has only substance units: false
name: (S)-Hydroxydecanoyl-CoA
is: CHEBI:28325
is: SBO:0000247
constant: false
type: Species
initial concentration: 1.0
initial amount: NaN
boundary condition: false

metaM xol7aone m
notes: FORMULA: C27H44O2 CHARGE: 0 INCHI: InChI=1S/C27H44O2/c1-17(2)7-6-8-18(3)21-9-10-22-25-23(12-14-27(21,22)5)26(4)13-11-20(28)15-19(26)16-24(25)29/h15,17-18,21-25,29H,6-14,16H2,1-5H3/t18-,21-,22+,23+,24-,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01464 EHMN_ABBREVIATION: C05455
is: HMDB01993
type: Species
is: SBO:0000247
boundary condition: false
is: CHEBI:17899
initial concentration: 1.0
name: 7alpha-hydroxycholest-4-en-3-one
has only substance units: false
initial amount: NaN
constant: false

metaM aicar e
boundary condition: false
initial amount: NaN
constant: false
is: CHEBI:58475
type: Species
notes: FORMULA: C9H13N4O8P CHARGE: -2
has only substance units: false
is: SBO:0000247
initial concentration: 1.0
is: C04677
is: HMDB01517
name: 5-Amino-1-(5-Phospho-D-ribosyl)imidazole-4-carboxamide

metaM dudp m
initial amount: NaN
is: SBO:0000247
type: Species
has only substance units: false
constant: false
is: CHEBI:60471
boundary condition: false
is: HMDB01000
name: dUDP(3-)
notes: FORMULA: C9H11N2O11P2 CHARGE: -3 INCHI: InChI=1S/C9H14N2O11P2/c12-5-3-8(11-2-1-7(13)10-9(11)14)21-6(5)4-20-24(18,19)22-23(15,16)17/h1-2,5-6,8,12H,3-4H2,(H,18,19)(H,10,13,14)(H2,15,16,17)/p-3/t5-,6+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00768 EHMN_ABBREVIATION: C01346
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110045#_ab0acd1c_148c_48e3_bdff_0926b44fc01c
type: Species
name: GALNT9
initial amount: NaN
boundary condition: true
is: SBO:0000252
constant: false
is encoded by: hsa:50614
initial concentration: NaN
is: Q9HCQ5
has only substance units: false

metaR EX pyr LPAREN e RPAREN
kinetic law: MODEL1310110045#
reactant: MODEL1310110045#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Pyruvate exchange
type: Reaction

metaM so4 e
has only substance units: false
initial concentration: 1.0
type: Species
constant: false
notes: FORMULA: O4S CHARGE: -2 INCHI: InChI=1S/H2O4S/c1-5(2,3)4/h(H2,1,2,3,4)/p-2 HEPATONET_1.0_ABBREVIATION: HC00062 EHMN_ABBREVIATION: C00059
boundary condition: false
is: SBO:0000247
name: sulfate
is: HMDB01448
is: CHEBI:16189
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110045#_859dded4_2fc6_4531_8e40_b3fafc999e16
initial amount: NaN
constant: false
name: GPD2
boundary condition: true
is encoded by: hsa:2820
is: P43304
initial concentration: NaN
has only substance units: false
is: SBO:0000252
type: Species

http://identifiers.org/biomodels.db/MODEL1310110045#_c0f0838f_65cf_4afb_bee3_ccfebacb608c
type: Species
name: _728637_1_c
initial amount: NaN
constant: false
boundary condition: true
is: SBO:0000252
has only substance units: false
initial concentration: NaN
is encoded by: hsa:728637

metaR RE2079R
is described by: ECO:0000000
reactant: MODEL1310110045#
is: SBO:0000176
type: Reaction
kinetic law: MODEL1310110045#
product: MODEL1310110045#
name: RE2079
fast: false
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Eicosanoid metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:10200320,PMID:11786541,PMID:8521498,PMID:9755286 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110045#_798b817a_1866_4a7a_ab09_9497c4c1bfa0
initial amount: NaN
type: Species
constant: false
is encoded by: hsa:221823
boundary condition: true
is: P21108
name: PRPS1L1
initial concentration: NaN
has only substance units: false
is: SBO:0000252

metaM glcur c
is: HMDB00127
type: Species
is: CHEBI:15748
has only substance units: false
notes: FORMULA: C6H9O7 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00182 EHMN_ABBREVIATION: C00191
is: SBO:0000247
initial concentration: 1.0
constant: false
boundary condition: false
name: D-glucuronate
initial amount: NaN

metaM c12dccoa x
is: SBO:0000247
notes: FORMULA: C33H51N7O19P3S CHARGE: -5
name: dodecanedioylcoa
is: C14143
boundary condition: false
type: Species
constant: false
has only substance units: false
is: HMDB04047
initial concentration: 1.0
initial amount: NaN

metaR r2089
is described by: ECO:0000000
reversible: true
type: Reaction
kinetic law: MODEL1310110045#
reactant: MODEL1310110045#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
modifier: MODEL1310110045#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
fast: false
product: MODEL1310110045#
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110045#_367240de_63c2_4283_96a6_5f39e4a3ac0e
constant: false
initial amount: NaN
is: Q9H2X9
name: SLC12A5
is encoded by: hsa:57468
boundary condition: true
initial concentration: NaN
has only substance units: false
is: SBO:0000252
type: Species

metaR r0801
type: Reaction
product: MODEL1310110045#
name: Mitochondrial Carrier (MC) TCDB:2.A.29.21.1
fast: false
reactant: MODEL1310110045#
kinetic law: MODEL1310110045#
notes: GENE_ASSOCIATION: (220.1) or (218.1) or (221.1) or (222.1) or (U37519.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:11078702 NOTES:
is described by: ECO:0000000
is: SBO:0000185
reversible: true
modifier: MODEL1310110045#
is version of: http://identifiers.org/ec-code/1.2.1.5

metaM zymstnl r
is: HMDB06841
has only substance units: false
initial concentration: 1.0
type: Species
initial amount: NaN
is: CHEBI:16608
name: 5alpha-cholest-8-en-3beta-ol
notes: FORMULA: C27H46O CHARGE: 0 INCHI: InChI=1S/C27H46O/c1-18(2)7-6-8-19(3)23-11-12-24-22-10-9-20-17-21(28)13-15-26(20,4)25(22)14-16-27(23,24)5/h18-21,23-24,28H,6-17H2,1-5H3/t19-,20+,21+,23-,24+,26+,27-/m1/s1 EHMN_ABBREVIATION: C03845
is: SBO:0000247
boundary condition: false
constant: false

http://identifiers.org/biomodels.db/MODEL1310110045#_23115150_434b_4acf_8066_99cbd0385efc
initial concentration: NaN
constant: false
is: P24752
has only substance units: false
initial amount: NaN
boundary condition: true
name: ACAT1
is: SBO:0000252
type: Species
is encoded by: hsa:38

http://identifiers.org/biomodels.db/MODEL1310110045#_513f2ee5_4a24_4834_a614_dff9523b3c0b
type: Species
has only substance units: false
constant: false
name: DDC
initial amount: NaN
boundary condition: true
is encoded by: hsa:1644
is: Q53Y41
initial concentration: NaN
is: SBO:0000252

metaR FAOXC142C122m
kinetic law: MODEL1310110045#
product: MODEL1310110045#
reactant: MODEL1310110045#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C14:2-->C12:2)m
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110045#_ac5547eb_2ad3_48c2_84a2_7248b25b2741
is encoded by: hsa:5136
initial concentration: NaN
initial amount: NaN
is: SBO:0000252
has only substance units: false
type: Species
is: P54750
name: PDE1A
constant: false
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110045#_d350168e_e53c_4455_adbc_3073b17b63d1
initial amount: NaN
boundary condition: true
constant: false
is: P08195
has only substance units: false
is encoded by: hsa:6520
type: Species
name: SLC3A2
is: SBO:0000252
initial concentration: NaN

metaM 6pgc r
initial amount: NaN
name: 6-phosphonatooxy-D-gluconate
type: Species
boundary condition: false
initial concentration: 1.0
constant: false
has only substance units: false
is: CHEBI:58759
is: SBO:0000247
is: HMDB01316
notes: FORMULA: C6H10O10P CHARGE: -3 INCHI: InChI=1S/C6H13O10P/c7-2(1-16-17(13,14)15)3(8)4(9)5(10)6(11)12/h2-5,7-10H,1H2,(H,11,12)(H2,13,14,15)/p-3/t2-,3-,4+,5-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00292 EHMN_ABBREVIATION: C00345

metaR S6TASE5ly
name: N-acetylgalactosamine-6-sulfatase, lysosomal
is version of: http://identifiers.org/ec-code/3.2.1.18
reactant: MODEL1310110045#
type: Reaction
is version of: http://identifiers.org/ec-code/3.1.6.4
modifier: MODEL1310110045#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.2.1.23
fast: false
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) SUBSYSTEM: Chondroitin sulfate degradation EC Number: 3.1.6.4 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD
kinetic law: MODEL1310110045#
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/3.4.16.5
product: MODEL1310110045#
reversible: true

metaM 9 cis retfa e
type: Species
constant: false
notes: FORMULA: C20H29OFULLR2CO CHARGE: 0
is: HMDB00224
is: SBO:0000247
boundary condition: false
initial concentration: 1.0
name: fatty acid 9-cis-retinol
has only substance units: false
initial amount: NaN
is: CHEBI:58190

http://identifiers.org/biomodels.db/MODEL1310110045#_0c99bb60_1481_4c74_b6f5_49abcb404b1f
name: CA6
is: SBO:0000252
is: Q5FC00
boundary condition: true
constant: false
initial concentration: NaN
is encoded by: hsa:765
type: Species
initial amount: NaN
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110045#_45b708e6_b961_4e7a_9f94_4e522071c20e
has only substance units: false
boundary condition: true
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:686
is: P43251
name: BTD
initial amount: NaN
type: Species
constant: false

http://identifiers.org/biomodels.db/MODEL1310110045#_6d2d7cdb_f9b9_424c_87a8_c6fdf28621ef
initial concentration: NaN
type: Species
initial amount: NaN
name: PYCR2
has only substance units: false
constant: false
is encoded by: hsa:29920
is: Q96C36
boundary condition: true
is: SBO:0000252

metaR HISyLATtc
kinetic law: MODEL1310110045#
product: MODEL1310110045#
reactant: MODEL1310110045#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: Transport of L-Histidine by y+LAT1 or y+LAT2 transporters in small intestine and kidney
type: Reaction

metaR r0915
product: MODEL1310110045#
is described by: ECO:0000000
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:16919238,PMID:17173541,PMID:18406340,PMID:8132483 NOTES:
kinetic law: MODEL1310110045#
type: Reaction
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
reactant: MODEL1310110045#
fast: false
is: SBO:0000185

metaM aicar c
is: HMDB01517
is: CHEBI:58475
initial amount: NaN
constant: false
type: Species
has only substance units: false
initial concentration: 1.0
notes: FORMULA: C9H13N4O8P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC01334 EHMN_ABBREVIATION: C04677
is: SBO:0000247
name: 5-Amino-1-(5-Phospho-D-ribosyl)imidazole-4-carboxamide
boundary condition: false
is: C04677

metaR LCADi
is described by: ECO:0000304
name: lactaldehyde dehydrogenase
product: MODEL1310110045#
modifier: MODEL1310110045#
reversible: false
fast: false
kinetic law: MODEL1310110045#
is version of: http://identifiers.org/ec-code/1.2.1.36
is version of: http://identifiers.org/ec-code/1.2.1.3
is version of: http://identifiers.org/ec-code/1.2.1.5
type: Reaction
reactant: MODEL1310110045#
notes: GENE_ASSOCIATION: (218.1) or (223.1) or (8854.2) or (224.1) or (222.1) or (8854.1) or (221.1) or (216.1) or (8854.3) or (501.1) or (220.1) SUBSYSTEM: Pyruvate metabolism EC Number: 1.2.1.21 Confidence Level: 2 AUTHORS: PMID:15987839,PMID:2296157,PMID:6487654 NOTES:JLR- added irreversible form of LCAD
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110045#_34e55d59_3cb4_4da0_8ac9_d265606ef556
is: SBO:0000252
is: E9PCP2
initial amount: NaN
is encoded by: hsa:1375
name: CPT1B
has only substance units: false
constant: false
initial concentration: NaN
boundary condition: true
type: Species

metaR r1106
fast: false
product: MODEL1310110045#
reversible: true
name: Postulated transport reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:10049700,PMID:10574970,PMID:11389679,PMID:11557028,PMID:11564694,PMID:12824232,PMID:12930836,PMID:14574404,PMID:16288981,PMID:911815 NOTES:
reactant: MODEL1310110045#
kinetic law: MODEL1310110045#
is: SBO:0000185
is described by: ECO:0000000
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110045#_597adec1_2dd8_47ed_9f9b_259b2bdce05e
initial amount: NaN
is encoded by: hsa:7372
name: UMPS
has only substance units: false
is: A8K5J1
initial concentration: NaN
boundary condition: true
constant: false
type: Species
is: SBO:0000252

metaM so4 c
notes: FORMULA: O4S CHARGE: -2 INCHI: InChI=1S/H2O4S/c1-5(2,3)4/h(H2,1,2,3,4)/p-2 HEPATONET_1.0_ABBREVIATION: HC00062 EHMN_ABBREVIATION: C00059
initial amount: NaN
type: Species
boundary condition: false
constant: false
name: sulfate
is: SBO:0000247
is: HMDB01448
has only substance units: false
initial concentration: 1.0
is: CHEBI:16189

metaR r1671
fast: false
kinetic law: MODEL1310110045#
reactant: MODEL1310110045#
reversible: true
is: SBO:0000185
name: Y+LAT2 Utilized transport
product: MODEL1310110045#
type: Reaction
is described by: ECO:0000000
modifier: MODEL1310110045#
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:

metaR SIAASEly
name: sialidase, lysosomal
is version of: http://identifiers.org/ec-code/3.2.1.18
reversible: false
is version of: http://identifiers.org/ec-code/3.4.16.5
reactant: MODEL1310110045#
kinetic law: MODEL1310110045#
is described by: ECO:0000000
fast: false
product: MODEL1310110045#
is version of: http://identifiers.org/ec-code/3.2.1.23
is: SBO:0000176
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) SUBSYSTEM: N-glycan degradation EC Number: 3.2.1.18 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD
modifier: MODEL1310110045#
is version of: http://identifiers.org/ec-code/3.1.6.4
type: Reaction

metaR CYTK8n
is: SBO:0000176
fast: false
name: cytidylate kinase (CMP,dATP),nuclear
kinetic law: MODEL1310110045#
reactant: MODEL1310110045#
is version of: http://identifiers.org/ec-code/2.7.4.14
type: Reaction
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
product: MODEL1310110045#
reversible: true
is described by: ECO:0000269
modifier: MODEL1310110045#

metaR r2087
reversible: true
type: Reaction
is: SBO:0000185
reactant: MODEL1310110045#
kinetic law: MODEL1310110045#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
product: MODEL1310110045#
modifier: MODEL1310110045#
fast: false
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
is described by: ECO:0000000

metaM ade c
is: C00147
name: Adenine
constant: false
initial concentration: 1.0
is: HMDB00034
is: CHEBI:16708
is: SBO:0000247
type: Species
has only substance units: false
notes: FORMULA: C5H5N5 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00144 EHMN_ABBREVIATION: C00147
boundary condition: false
initial amount: NaN

metaM ksii core2 deg9 l
name: keratan sulfate II (core 2-linked), degradation product 9
constant: false
is: CHEBI:12936
notes: FORMULA: C30H50N3O20X CHARGE: 0
type: Species
initial concentration: 1.0
has only substance units: false
is: SBO:0000247
initial amount: NaN
is: HMDB00143
boundary condition: false

metaM glcur e
is: HMDB00127
constant: false
has only substance units: false
is: SBO:0000247
notes: FORMULA: C6H9O7 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00182 EHMN_ABBREVIATION: C00191
initial amount: NaN
initial concentration: 1.0
boundary condition: false
name: D-glucuronate
type: Species
is: CHEBI:15748

metaM mi1345p c
has only substance units: false
is: HMDB01059
is: SBO:0000247
type: Species
initial amount: NaN
constant: false
name: 1D-myo-inositol 1,3,4,5-tetrakisphosphate(8-)
notes: FORMULA: C6H8O18P4 CHARGE: -8 INCHI: InChI=1S/C6H16O18P4/c7-1-3(21-25(9,10)11)2(8)5(23-27(15,16)17)6(24-28(18,19)20)4(1)22-26(12,13)14/h1-8H,(H2,9,10,11)(H2,12,13,14)(H2,15,16,17)(H2,18,19,20)/p-8/t1-,2-,3-,4+,5-,6-/m0/s1 EHMN_ABBREVIATION: C01272
is: CHEBI:57895
initial concentration: 1.0
boundary condition: false

metaM dctp c
notes: FORMULA: C9H12N3O13P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00367 EHMN_ABBREVIATION: C00458
boundary condition: false
type: Species
is: C00458
is: HMDB00998
has only substance units: false
name: dCTP
constant: false
is: SBO:0000247
initial amount: NaN
initial concentration: 1.0
is: CHEBI:16311

metaM gluside hs c
is: SBO:0000247
notes: FORMULA: C24H46NO7FULLRCO CHARGE: 0 EHMN_ABBREVIATION: C01190
initial concentration: 1.0
has only substance units: false
type: Species
constant: false
boundary condition: false
initial amount: NaN
name: D-glucosyl-N-acylsphingosine
is: CHEBI:18368

metaR r1670
reactant: MODEL1310110045#
fast: false
product: MODEL1310110045#
modifier: MODEL1310110045#
is: SBO:0000185
kinetic law: MODEL1310110045#
type: Reaction
reversible: true
is described by: ECO:0000000
name: Y+LAT2 Utilized transport
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:

metaM glyc m
type: Species
is: SBO:0000247
is: C00116
is: HMDB00131
boundary condition: false
initial concentration: 1.0
is: CHEBI:17754
has only substance units: false
notes: FORMULA: C3H8O3 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00114 EHMN_ABBREVIATION: C00116
constant: false
initial amount: NaN
name: Glycerol

http://identifiers.org/biomodels.db/MODEL1310110045#_c65c37ba_7d1d_4545_9a19_deb3a3bbdb85
name: ZADH2
boundary condition: true
is: SBO:0000252
initial amount: NaN
constant: false
has only substance units: false
is: Q4G1C4
is encoded by: hsa:284273
initial concentration: NaN
type: Species

http://identifiers.org/biomodels.db/MODEL1310110045#_949d6189_e1ca_4afb_b8f0_952e0b4bf0f1
name: NDUFV1
is encoded by: hsa:4723
boundary condition: true
is: E5KNH5
type: Species
constant: false
has only substance units: false
initial amount: NaN
is: SBO:0000252
initial concentration: NaN

metaR G14T14g
is version of: http://identifiers.org/ec-code/2.4.1.38
kinetic law: MODEL1310110045#
is: SBO:0000176
reversible: false
modifier: MODEL1310110045#
product: MODEL1310110045#
is version of: http://identifiers.org/ec-code/2.4.1.90
fast: false
notes: GENE_ASSOCIATION: (8703.1) or (8704.2) or (8704.1) or (2683.1) or (9334.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.38 Confidence Level: 4 AUTHORS: PMID:12512857,PMID:1903938,PMID:3094506,PMID:3144273,PMID:9405390,PMID:9435216 NOTES:Keratan sulfate I biosynthesis NCD
type: Reaction
reactant: MODEL1310110045#
name: beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase, Golgi
is version of: http://identifiers.org/ec-code/2.4.1.22
is described by: ECO:0000000

metaM m3mpdol L c
is: CHEBI:37632
is: SBO:0000247
name: (alpha-D-mannosyl)3-beta-D-mannosyl-diacetylchitodiphosphodolichol, human liver homolog
notes: FORMULA: C1480H2428N20O370P20 CHARGE: -20
initial concentration: 1.0
has only substance units: false
type: Species
initial amount: NaN
boundary condition: false
constant: false

http://identifiers.org/biomodels.db/MODEL1310110045#_532a657a_231b_4cf6_94a0_e659eeee34e4
has only substance units: false
type: Species
initial amount: NaN
initial concentration: NaN
boundary condition: true
is encoded by: hsa:3992
is: O60427
name: FADS1
constant: false
is: SBO:0000252

metaR GALASE12ly
is version of: http://identifiers.org/ec-code/3.2.1.23
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) or (5476.1) and (2720.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.23 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD
is version of: http://identifiers.org/ec-code/3.2.1.18
type: Reaction
product: MODEL1310110045#
reactant: MODEL1310110045#
is: SBO:0000176
modifier: MODEL1310110045#
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/3.1.6.4
is version of: http://identifiers.org/ec-code/3.4.16.5
fast: false
reversible: false
name: beta-galactosidase, lysosomal
kinetic law: MODEL1310110045#

metaR r2088
is described by: ECO:0000000
modifier: MODEL1310110045#
type: Reaction
kinetic law: MODEL1310110045#
reversible: true
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
fast: false
product: MODEL1310110045#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
is: SBO:0000185
reactant: MODEL1310110045#

metaM fum m
has only substance units: false
constant: false
notes: FORMULA: C4H2O4 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00120 EHMN_ABBREVIATION: C00122
initial amount: NaN
type: Species
name: Fumarate
is: C00122
is: SBO:0000247
boundary condition: false
is: HMDB00134
is: CHEBI:29806
initial concentration: 1.0

metaR ADKd
kinetic law: MODEL1310110045#
name: adenylate kinase (d form)
is version of: http://identifiers.org/ec-code/2.7.4.3
type: Reaction
notes: GENE_ASSOCIATION: (26289.2) or (26289.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.3 Confidence Level: 4 AUTHORS: PMID:10215863 NOTES:Inorganic triphosphate can also act as donor This form was added for Staph based on KEGG evidence (SAB)
product: MODEL1310110045#
modifier: MODEL1310110045#
reactant: MODEL1310110045#
is: SBO:0000176
reversible: true
fast: false
is described by: ECO:0000269

http://identifiers.org/biomodels.db/MODEL1310110045#_7ced9ce9_7969_4696_95c8_db2e098820bb
constant: false
initial concentration: NaN
type: Species
has only substance units: false
is: O75390
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:1431
boundary condition: true
name: CS

http://identifiers.org/biomodels.db/MODEL1310110045#_c17fc5f3_64f6_47b4_bab6_4509d91a82f0
type: Species
has only substance units: false
is encoded by: hsa:221823
initial concentration: NaN
is: SBO:0000252
boundary condition: true
name: PRPS1L1
constant: false
initial amount: NaN

metaR r2085
product: MODEL1310110045#
modifier: MODEL1310110045#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
is described by: ECO:0000000
kinetic law: MODEL1310110045#
type: Reaction
fast: false
reversible: true
is: SBO:0000185
reactant: MODEL1310110045#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110045#_f29aa048_29ca_4460_9ba4_31ebc8268a69
initial amount: NaN
boundary condition: true
name: AKR1A1
is encoded by: hsa:10327
constant: false
type: Species
has only substance units: false
is: SBO:0000252
initial concentration: NaN

metaM dump m
is: HMDB01409
type: Species
is: SBO:0000247
boundary condition: false
is: CHEBI:246422
constant: false
initial concentration: 1.0
initial amount: NaN
has only substance units: false
name: dUMP(2-)
notes: FORMULA: C9H11N2O8P CHARGE: -2 INCHI: InChI=1S/C9H13N2O8P/c12-5-3-8(11-2-1-7(13)10-9(11)14)19-6(5)4-18-20(15,16)17/h1-2,5-6,8,12H,3-4H2,(H,10,13,14)(H2,15,16,17)/p-2/t5-,6+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00309 EHMN_ABBREVIATION: C00365

metaR EX utp LPAREN e RPAREN
kinetic law: MODEL1310110045#
reactant: MODEL1310110045#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: UTP exchange
type: Reaction

metaM ade e
initial concentration: 1.0
is: CHEBI:16708
constant: false
has only substance units: false
boundary condition: false
is: HMDB00034
name: adenine
is: SBO:0000247
initial amount: NaN
notes: FORMULA: C5H5N5 CHARGE: 0 INCHI: InChI=1S/C5H5N5/c6-4-3-5(9-1-7-3)10-2-8-4/h1-2H,(H3,6,7,8,9,10) HEPATONET_1.0_ABBREVIATION: HC00144 EHMN_ABBREVIATION: C00147
type: Species

http://identifiers.org/biomodels.db/MODEL1310110045#_ec5a47dc_145d_4898_a46e_82080e340b27
boundary condition: true
name: FUT8
is: SBO:0000252
is encoded by: hsa:2530
initial amount: NaN
is: B4DFS7
has only substance units: false
type: Species
initial concentration: NaN
constant: false

metaR r0178
is version of: http://identifiers.org/ec-code/2.5.1.21
fast: false
modifier: MODEL1310110045#
is: SBO:0000176
kinetic law: MODEL1310110045#
reactant: MODEL1310110045#
is described by: ECO:0000000
product: MODEL1310110045#
reversible: true
name: Succinate-semialdehyde:NAD+ oxidoreductase Glutamate metabolism / Tyrosine metabolism / Butanoate metabolism EC:1.2.1.24 EC:1.2.1.16
type: Reaction
notes: GENE_ASSOCIATION: (2222.1) SUBSYSTEM: Glutamate metabolism EC Number: 1.2.1.24 Confidence Level: 0 AUTHORS: PMID:3190233,PMID:656447,PMID:7616245,PMID:7814412 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110045#_299a85bc_f73d_448e_a811_52f521f545fb
boundary condition: true
name: SHMT1
constant: false
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:6470
type: Species
has only substance units: false
initial amount: NaN

metaM ksi pre14 g
is: CHEBI:28067
initial concentration: 1.0
initial amount: NaN
notes: FORMULA: C143H230N10O114S4X CHARGE: -5
boundary condition: false
name: keratan sulfate I biosynthesis, precursor 14
has only substance units: false
constant: false
is: SBO:0000247
type: Species

http://identifiers.org/biomodels.db/MODEL1310110045#_04d1c150_0022_44e1_bece_ddc70ac4b585
initial concentration: NaN
constant: false
initial amount: NaN
has only substance units: false
type: Species
name: ALG8
is: A6NDW6
is: SBO:0000252
boundary condition: true
is encoded by: hsa:79053

metaM dump n
is: HMDB01409
constant: false
name: dUMP(2-)
type: Species
is: CHEBI:246422
initial concentration: 1.0
is: SBO:0000247
has only substance units: false
notes: FORMULA: C9H11N2O8P CHARGE: -2 INCHI: InChI=1S/C9H13N2O8P/c12-5-3-8(11-2-1-7(13)10-9(11)14)19-6(5)4-18-20(15,16)17/h1-2,5-6,8,12H,3-4H2,(H,10,13,14)(H2,15,16,17)/p-2/t5-,6+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00309 EHMN_ABBREVIATION: C00365
boundary condition: false
initial amount: NaN

metaM but e
has only substance units: false
initial concentration: 1.0
is: SBO:0000247
initial amount: NaN
is: HMDB00039
constant: false
is: CHEBI:17968
type: Species
notes: FORMULA: C4H7O2 CHARGE: -1 INCHI: InChI=1S/C4H8O2/c1-2-3-4(5)6/h2-3H2,1H3,(H,5,6)/p-1 HEPATONET_1.0_ABBREVIATION: HC00223 EHMN_ABBREVIATION: C00246
boundary condition: false
name: butyrate

metaM odecoa m
boundary condition: false
is: SBO:0000247
initial concentration: 1.0
name: Octadecenoyl-CoA (n-C18:1CoA)
type: Species
is: CHEBI:57387
has only substance units: false
notes: FORMULA: C39H64N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00400 EHMN_ABBREVIATION: C00510
constant: false
is: HMDB01322
initial amount: NaN

metaR r2086
kinetic law: MODEL1310110045#
reactant: MODEL1310110045#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
is described by: ECO:0000000
reversible: true
type: Reaction
product: MODEL1310110045#
fast: false
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
modifier: MODEL1310110045#
is: SBO:0000185

metaM ca2 c
is: SBO:0000247
initial concentration: 1.0
is: CHEBI:29108
initial amount: NaN
notes: FORMULA: Ca CHARGE: 2 INCHI: InChI=1S/Ca/q+2 EHMN_ABBREVIATION: C00076
constant: false
has only substance units: false
type: Species
is: HMDB00464
name: calcium(2+)
boundary condition: false

metaR r0179
is version of: http://identifiers.org/ec-code/1.1.1.27
is described by: ECO:0000000
reversible: true
fast: false
type: Reaction
kinetic law: MODEL1310110045#
notes: GENE_ASSOCIATION: (AI656480.1) or (BE042354.1) or (3939.1) or (92483.1) or (3945.1) or (3948.1) SUBSYSTEM: Glutamate metabolism EC Number: 1.2.1.16 Confidence Level: 0 AUTHORS: PMID:4066712,PMID:7814412 NOTES:
name: Succinate-semialdehyde:NADP+ oxidoreductase Glutamate metabolism / Tyrosine metabolism / Butanoate metabolism EC:1.2.1.16
reactant: MODEL1310110045#
product: MODEL1310110045#
modifier: MODEL1310110045#
is: SBO:0000176

metaM HC02214 c
initial concentration: 1.0
boundary condition: false
is: SBO:0000247
is: CHEBI:28852
initial amount: NaN
name: prostaglandin-f1alpha
notes: FORMULA: C20H35O5 CHARGE: -1 INCHI: InChI=1S/C20H36O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h12-13,15-19,21-23H,2-11,14H2,1H3,(H,24,25)/b13-12+/t15-,16+,17+,18-,19+/m0/s1
constant: false
has only substance units: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110045#_09e59c06_7f2c_44ac_9037_833ce09c19d3
is: Q13011
initial concentration: NaN
constant: false
is encoded by: hsa:1891
initial amount: NaN
type: Species
has only substance units: false
boundary condition: true
name: ECH1
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110045#_2e4efb80_b7f1_425b_afd7_f076981e939a
type: Species
constant: false
is encoded by: hsa:6817
boundary condition: true
name: SULT1A1
is: SBO:0000252
has only substance units: false
initial amount: NaN
initial concentration: NaN

metaR Htr
is described by: ECO:0000000
kinetic law: MODEL1310110045#
type: Reaction
product: MODEL1310110045#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: NOTES:diffusion NJ
reactant: MODEL1310110045#
fast: false
name: H transporter, endoplasmic reticulum
reversible: true

metaR r0560
reversible: false
reactant: MODEL1310110045#
kinetic law: MODEL1310110045#
product: MODEL1310110045#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 1.3.99.2 Confidence Level: 0 AUTHORS: PMID:12855692,PMID:3597357,PMID:6401712,PMID:6874697 NOTES:
type: Reaction
is: SBO:0000176
name: 2-Methylpropanoyl-CoA:oxygen 2,3-oxidoreductase Valine, leucine and isoleucine degradation EC:1.3.99.2
fast: false

http://identifiers.org/biomodels.db/MODEL1310110045#_125e34f4_a02b_46a0_99b5_901279c6721f
is: SBO:0000252
boundary condition: true
constant: false
is encoded by: hsa:50940
initial concentration: NaN
is: Q9HCR9
type: Species
has only substance units: false
name: PDE11A
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110045#_55536835_a102_4223_90c4_2ea950625a03
constant: false
is encoded by: hsa:2821
is: SBO:0000252
initial amount: NaN
has only substance units: false
initial concentration: NaN
boundary condition: true
is: P06744
name: GPI
type: Species

metaR FPGS4m
name: folylpolyglutamate synthetase (DHF), mitochondrial
reactant: MODEL1310110045#
kinetic law: MODEL1310110045#
is: SBO:0000176
product: MODEL1310110045#
type: Reaction
reversible: false
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/6.3.2.17
notes: GENE_ASSOCIATION: (2356.1) SUBSYSTEM: Folate metabolism EC Number: 6.3.2.17 Confidence Level: 4 AUTHORS: PMID:10777604 NOTES:IT
modifier: MODEL1310110045#
fast: false

metaR r1648
is described by: ECO:0000000
fast: false
modifier: MODEL1310110045#
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
type: Reaction
is: SBO:0000185
reactant: MODEL1310110045#
product: MODEL1310110045#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reversible: true
kinetic law: MODEL1310110045#

metaM Rtotalcoa c
notes: FORMULA: CO2FULLRC21H31N7O15P3S CHARGE: -4
is: CHEBI:16189
type: Species
initial amount: NaN
initial concentration: 1.0
is: SBO:0000247
boundary condition: false
has only substance units: false
constant: false
name: R total Coenzyme A
is: HMDB01448

metaR r0974
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:10334869,PMID:12603856,PMID:17024033,PMID:9516450 NOTES:
reversible: true
is described by: ECO:0000000
is: SBO:0000185
name: Active transport
reactant: MODEL1310110045#
kinetic law: MODEL1310110045#
type: Reaction
product: MODEL1310110045#
fast: false

metaR DNDPt16m
product: MODEL1310110045#
is described by: ECO:0000269
name: dUDP transport via dADP antiport
modifier: MODEL1310110045#
type: Reaction
reversible: false
reactant: MODEL1310110045#
fast: false
kinetic law: MODEL1310110045#
notes: GENE_ASSOCIATION: (60386.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:11226231 NOTES:IT
is: SBO:0000185

metaM 3hmp m
boundary condition: false
initial concentration: 1.0
is: HMDB00023
has only substance units: false
is: SBO:0000247
notes: FORMULA: C4H7O3 CHARGE: -1 INCHI: InChI=1S/C4H8O3/c1-3(2-5)4(6)7/h3,5H,2H2,1H3,(H,6,7)/p-1 HEPATONET_1.0_ABBREVIATION: HC00705 EHMN_ABBREVIATION: C01188
initial amount: NaN
is: CHEBI:11805
type: Species
constant: false
name: 3-hydroxy-2-methylpropanoate

http://identifiers.org/biomodels.db/MODEL1310110045#_7626eb42_d9ec_4f56_be09_169b7fe38a83
constant: false
type: Species
initial concentration: NaN
name: _HG2846_HT2983_1_m
is encoded by: hsa:HG2846-HT2983
initial amount: NaN
is: SBO:0000252
boundary condition: true
has only substance units: false

metaM 3mob c
has only substance units: false
initial amount: NaN
boundary condition: false
name: 3-methyl-2-oxobutanoate
is: HMDB00019
notes: FORMULA: C5H7O3 CHARGE: -1 INCHI: InChI=1S/C5H8O3/c1-3(2)4(6)5(7)8/h3H,1-2H3,(H,7,8)/p-1 HEPATONET_1.0_ABBREVIATION: HC00139 EHMN_ABBREVIATION: C00141
is: SBO:0000247
constant: false
initial concentration: 1.0
type: Species
is: CHEBI:11851

metaM T antigen g
boundary condition: false
notes: FORMULA: C14H24NO10X CHARGE: 0
has only substance units: false
initial amount: NaN
initial concentration: 1.0
name: T antigen (core 1)
type: Species
constant: false
is: SBO:0000247
is: CHEBI:22783

http://identifiers.org/biomodels.db/MODEL1310110045#_fa3084e4_8a3a_44ba_bb7b_8f529caa3444
initial amount: NaN
boundary condition: true
is: Q96I99
name: SUCLG2
type: Species
is: SBO:0000252
is encoded by: hsa:8801
initial concentration: NaN
constant: false
has only substance units: false

metaR r1647
reversible: true
is: SBO:0000185
reactant: MODEL1310110045#
product: MODEL1310110045#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is described by: ECO:0000000
modifier: MODEL1310110045#
type: Reaction
kinetic law: MODEL1310110045#
fast: false
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110045#_6c0ca28a_e789_4b96_930e_425248dbd24b
type: Species
is: SBO:0000252
boundary condition: true
is encoded by: hsa:1350
has only substance units: false
initial concentration: NaN
name: COX7C
is: P15954
initial amount: NaN
constant: false

metaR r0975
reversible: false
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:1260500 NOTES:
product: MODEL1310110045#
fast: false
type: Reaction
name: Facilitated diffusion
is: SBO:0000185
reactant: MODEL1310110045#
kinetic law: MODEL1310110045#

http://identifiers.org/biomodels.db/MODEL1310110045#_5d3b1b38_b2da_400b_9694_559bc39dd19b
has only substance units: false
is: SBO:0000252
constant: false
is encoded by: hsa:6566
initial concentration: NaN
initial amount: NaN
boundary condition: true
is: B4DKS0
type: Species
name: SLC16A1

metaM HC01405 m
initial amount: NaN
initial concentration: 1.0
type: Species
notes: FORMULA: C29H46N7O18P3S CHARGE: -4 INCHI: InChI=1S/C29H50N7O18P3S/c1-4-5-6-7-17(37)12-20(39)58-11-10-31-19(38)8-9-32-27(42)24(41)29(2,3)14-51-57(48,49)54-56(46,47)50-13-18-23(53-55(43,44)45)22(40)28(52-18)36-16-35-21-25(30)33-15-34-26(21)36/h15-18,22-24,28,37,40-41H,4-14H2,1-3H3,(H,31,38)(H,32,42)(H,46,47)(H,48,49)(H2,30,33,34)(H2,43,44,45)/t17-,18+,22+,23+,24-,28+/m0/s1 EHMN_ABBREVIATION: C05266
is: CHEBI:28632
name: (S)-Hydroxyoctanoyl-CoA
is: SBO:0000247
has only substance units: false
constant: false
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110045#_f4848d0b_345b_43f3_9191_e6c2b16f6f1f
is: SBO:0000252
name: NDUFA2
initial concentration: NaN
has only substance units: false
type: Species
boundary condition: true
is: O43678
initial amount: NaN
constant: false
is encoded by: hsa:4695

http://identifiers.org/biomodels.db/MODEL1310110045#_808010d6_7e0c_4ceb_84ad_24ffd69e3dd2
initial amount: NaN
constant: false
initial concentration: NaN
boundary condition: true
has only substance units: false
is encoded by: hsa:4594
type: Species
name: MUT
is: SBO:0000252
is: P22033

metaR GALT
product: MODEL1310110045#
name: galactose-1-phosphate uridylyltransferase
is: SBO:0000176
notes: GENE_ASSOCIATION: (2592.1) or (2592.3) or (2592.2) SUBSYSTEM: Galactose metabolism EC Number: 2.7.7.12 Confidence Level: 0 AUTHORS: PMID:1427861 NOTES:
reactant: MODEL1310110045#
is version of: http://identifiers.org/ec-code/2.7.7.12
modifier: MODEL1310110045#
fast: false
kinetic law: MODEL1310110045#
type: Reaction
is described by: ECO:0000000
reversible: true

metaR PROSTGH2t
is described by: ECO:0000269
product: MODEL1310110045#
reactant: MODEL1310110045#
reversible: true
kinetic law: MODEL1310110045#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:12827517,PMID:12883891,PMID:9187257 NOTES:
name: Prostaglandin H2 transport
is: SBO:0000185
type: Reaction
fast: false

metaR CLHCO3tex2
name: chloride transport via bicarbonate countertransport (2:1)
fast: false
reactant: MODEL1310110045#
is described by: ECO:0000304
modifier: MODEL1310110045#
notes: GENE_ASSOCIATION: (65010.1) or (65010.3) or (65010.2) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:12759755 NOTES:SAB
reversible: false
kinetic law: MODEL1310110045#
product: MODEL1310110045#
type: Reaction
is: SBO:0000185

metaR r1915
fast: false
reversible: false
name: Y+LAT2 Utilized transport
reactant: MODEL1310110045#
modifier: MODEL1310110045#
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
kinetic law: MODEL1310110045#
is described by: ECO:0000000
is: SBO:0000185
product: MODEL1310110045#
type: Reaction

metaR PIPLC
name: phosphatidylinositol phospholipase C
reactant: MODEL1310110045#
is: SBO:0000176
is described by: ECO:0000000
kinetic law: MODEL1310110045#
notes: GENE_ASSOCIATION: (23236.2) or (5336.1) or (23007.1) or (113026.1) or (89869.1) or (84812.1) or (9651.1) or (5335.1) or (51196.1) or (257068.1) or (5332.2) or (5331.1) or (5335.2) or (5334.1) or (5332.1) or (5330.1) or (23236.1) or (5333.1) SUBSYSTEM: Inositol phosphate metabolism EC Number: 3.1.4.3 Confidence Level: 4 AUTHORS: PMID:10702670,PMID:10702683,PMID:10760467,PMID:11022047,PMID:11022048,PMID:11118617,PMID:12117804,PMID:12213492,PMID:12416999,PMID:13333955,PMID:15140260,PMID:1644792,PMID:2167438,PMID:7607669,PMID:7612006,PMID:7633416,PMID:7789993,PMID:7835906,PMID:7849701,PMID:7890667,PMID:8530101,PMID:9345909 NOTES:NCD
modifier: MODEL1310110045#
fast: false
reversible: false
type: Reaction
product: MODEL1310110045#
is version of: http://identifiers.org/ec-code/3.1.4.11

metaR SPMTDe
type: Reaction
kinetic law: MODEL1310110045#
is: SBO:0000185
name: SPMTDe
reactant: MODEL1310110045#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
fast: false
product: MODEL1310110045#
reversible: true

metaM 3mob e
constant: false
initial amount: NaN
name: 3-methyl-2-oxobutanoate
type: Species
is: HMDB00019
notes: FORMULA: C5H7O3 CHARGE: -1 INCHI: InChI=1S/C5H8O3/c1-3(2)4(6)5(7)8/h3H,1-2H3,(H,7,8)/p-1
has only substance units: false
is: CHEBI:11851
initial concentration: 1.0
boundary condition: false
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110045#_a77328b7_cd29_4d3d_8dd1_64cd1ef655ad
initial concentration: NaN
is: SBO:0000252
name: AMY2A
boundary condition: true
is: P04746
is encoded by: hsa:279
initial amount: NaN
has only substance units: false
constant: false
type: Species

metaR GALU
kinetic law: MODEL1310110045#
is described by: ECO:0000134
modifier: MODEL1310110045#
notes: GENE_ASSOCIATION: (7360.1) or (7359.1) or (7360.2) SUBSYSTEM: Galactose metabolism EC Number: 2.7.7.9 Confidence Level: 0 AUTHORS: PMID:9119383 NOTES:Human Y/N: Y
name: UTP-glucose-1-phosphate uridylyltransferase
product: MODEL1310110045#
reactant: MODEL1310110045#
type: Reaction
reversible: true
fast: false
is version of: http://identifiers.org/ec-code/2.7.7.9
is: SBO:0000176

metaR r1649
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is described by: ECO:0000000
reversible: true
product: MODEL1310110045#
type: Reaction
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
modifier: MODEL1310110045#
fast: false
kinetic law: MODEL1310110045#
is: SBO:0000185
reactant: MODEL1310110045#

http://identifiers.org/biomodels.db/MODEL1310110045#_cc78f427_a6c7_4426_96eb_78a8b66cbfd5
is encoded by: hsa:1109
initial amount: NaN
type: Species
initial concentration: NaN
boundary condition: true
is: SBO:0000252
is: P17516
name: AKR1C4
constant: false
has only substance units: false

metaR CYANtm
reactant: MODEL1310110045#
is described by: ECO:0000000
name: Cyanide transport via diffusion (mitochondrial)
fast: false
kinetic law: MODEL1310110045#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: NOTES:assumed to be readily diffusible MM
type: Reaction
product: MODEL1310110045#
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110045#_04976b4a_c557_483a_b1e2_24857afc5dd4
boundary condition: true
is: SBO:0000252
has only substance units: false
is encoded by: hsa:11041
is: O43505
initial amount: NaN
type: Species
initial concentration: NaN
constant: false
name: B3GNT1

metaR 7DHCHSTEROLtr
reactant: MODEL1310110045#
product: MODEL1310110045#
reversible: true
type: Reaction
kinetic law: MODEL1310110045#
is: SBO:0000185
fast: false
name: cholesterol precursor intracellular transport
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: NOTES:specific mechanism not known, proton dependence for trans-mit transport has been suggested, however directionality and stoichiometry has not yet been elucidated. see PMID: 12770731 and others NJ
is described by: ECO:0000000

metaM l2n2m2mn l
type: Species
is: SBO:0000247
name: de-Fuc, reducing GlcNAc removed, de-Sia form of PA6 (w/o peptide linkage)
constant: false
initial concentration: 1.0
boundary condition: false
is: HMDB00143
initial amount: NaN
notes: FORMULA: C54H91N3O41 CHARGE: 0
has only substance units: false
is: CHEBI:12936

metaM ksi pre33 g
type: Species
constant: false
is: C00130
notes: FORMULA: C233H372N16O197S10X CHARGE: -11
has only substance units: false
initial concentration: 1.0
is: HMDB00175
is: CHEBI:58053
boundary condition: false
initial amount: NaN
is: SBO:0000247
name: keratan sulfate I biosynthesis, precursor 33

metaR DM pe hs LPAREN r RPAREN
kinetic law: MODEL1310110045#
reactant: MODEL1310110045#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 0 AUTHORS: PMID: 17173541 NOTES:added during gap-filling, no evidence for such a reaction. only assumed.
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: demand reaction for pe_hs[r]
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110045#_f56a1a74_89a8_4248_89bd_042543f0ec17
is encoded by: hsa:112724
constant: false
boundary condition: true
initial amount: NaN
is: B3KVA3
type: Species
initial concentration: NaN
name: RDH13
is: SBO:0000252
has only substance units: false

metaM 2obut m
has only substance units: false
constant: false
name: 2-oxobutanoate
initial concentration: 1.0
is: CHEBI:16763
is: SBO:0000247
initial amount: NaN
is: HMDB00005
notes: FORMULA: C4H5O3 CHARGE: -1 INCHI: InChI=1S/C4H6O3/c1-2-3(5)4(6)7/h2H2,1H3,(H,6,7)/p-1 HEPATONET_1.0_ABBREVIATION: HC00108 EHMN_ABBREVIATION: C00109
boundary condition: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110045#_d790d350_321c_4441_91e9_ff3a2a3a01a7
is encoded by: hsa:93010
boundary condition: true
initial concentration: NaN
name: B3GNT7
constant: false
initial amount: NaN
is: Q8NFL0
is: SBO:0000252
type: Species
has only substance units: false

metaR GLYSNAT5tc
kinetic law: MODEL1310110045#
product: MODEL1310110045#
reactant: MODEL1310110045#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: transport of Glycine into the cell coupled with co-transport with Sodium and counter transport with proton by SNAT5 transporter.
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110045#_7e618865_da13_4efc_bf36_52de8b8c82bf
type: Species
has only substance units: false
name: ACSL3
boundary condition: true
initial concentration: NaN
is: SBO:0000252
initial amount: NaN
is: O95573
is encoded by: hsa:2181
constant: false

http://identifiers.org/biomodels.db/MODEL1310110045#_0b05a2bc_c21d_4991_accc_58ca63915c4f
initial amount: NaN
initial concentration: NaN
has only substance units: false
constant: false
boundary condition: true
is: SBO:0000252
is: C9JT23
is encoded by: hsa:126328
name: NDUFA11
type: Species

metaR EX prpp LPAREN e RPAREN
kinetic law: MODEL1310110045#
reactant: MODEL1310110045#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of 5-O-phosphonato-alpha-D-ribofuranosyl diphosphate(5-)
type: Reaction

metaM triodthy c
has only substance units: false
notes: FORMULA: C15H12I3NO4 CHARGE: 0 INCHI: InChI=1S/C15H12I3NO4/c16-9-6-8(1-2-13(9)20)23-14-10(17)3-7(4-11(14)18)5-12(19)15(21)22/h1-4,6,12,20H,5,19H2,(H,21,22)/t12-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00943 EHMN_ABBREVIATION: C02465
is: CHEBI:18258
is: SBO:0000247
type: Species
constant: false
is: HMDB00265
boundary condition: false
initial amount: NaN
initial concentration: 1.0
name: 3,3',5-triiodo-L-thyronine

http://identifiers.org/biomodels.db/MODEL1310110045#_75b30acb_49cd_4213_98c0_86f1330e32d2
has only substance units: false
name: NDUFA11:NDUFS7:ND1:ND2:ND3:ND4:ND4L:ND5:ND6:NDUFA1:NDUFA2:NDUFA3:NDUFA4:NDUFA5:NDUFA6:NDUFA7:NDUFA8:NDUFA9:NDUFA10:NDUFAB1:NDUFB1:NDUFB2:NDUFB3:NDUFB4:NDUFB5:NDUFB6:NDUFB7:NDUFB8:NDUFB9:NDUFB10:NDUFC1:NDUFC2:NDUFS1:NDUFS2:NDUFS3:NDUFV1:NDUFS4:NDUFS5:NDUFS6:NDUFS8:NDUFV2:NDUFV3:NDUFA13:NDUFA12:TUSC3
initial concentration: NaN
is: SBO:0000297
is encoded by: hsa:7991
type: Species
initial amount: NaN
constant: false
boundary condition: true

metaM HC01115 c
name: NeuNGc
notes: FORMULA: C11H18NO10 CHARGE: -1 INCHI: InChI=1S/C11H19NO10/c13-2-5(16)8(18)9-7(12-6(17)3-14)4(15)1-11(21,22-9)10(19)20/h4-5,7-9,13-16,18,21H,1-3H2,(H,12,17)(H,19,20)/p-1/t4-,5+,7+,8+,9+,11?/m0/s1 EHMN_ABBREVIATION: C03410
constant: false
boundary condition: false
is: CHEBI:29025
initial amount: NaN
initial concentration: 1.0
is: SBO:0000247
has only substance units: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110045#_30d925a2_cf39_4755_b422_5ac106d1c386
is encoded by: hsa:1103
is: SBO:0000252
initial amount: NaN
boundary condition: true
is: Q6LEN5
has only substance units: false
constant: false
type: Species
initial concentration: NaN
name: CHAT

metaM xoltriol m
initial concentration: 1.0
is: HMDB01457
constant: false
boundary condition: false
has only substance units: false
initial amount: NaN
name: 5beta-cholestane-3alpha,7alpha,12alpha-triol
notes: FORMULA: C27H48O3 CHARGE: 0 INCHI: InChI=1S/C27H48O3/c1-16(2)7-6-8-17(3)20-9-10-21-25-22(15-24(30)27(20,21)5)26(4)12-11-19(28)13-18(26)14-23(25)29/h16-25,28-30H,6-15H2,1-5H3/t17-,18+,19-,20-,21+,22+,23-,24+,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01463 EHMN_ABBREVIATION: C05454
is: SBO:0000247
type: Species
is: CHEBI:16496

metaR r1934
type: Reaction
product: MODEL1310110045#
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
kinetic law: MODEL1310110045#
is: SBO:0000185
reversible: false
name: Y+LAT2 Utilized transport
modifier: MODEL1310110045#
is described by: ECO:0000000
fast: false
reactant: MODEL1310110045#

http://identifiers.org/biomodels.db/MODEL1310110045#_c02d5d67_189a_46d3_83ae_c8313df22f56
initial concentration: NaN
is: SBO:0000252
constant: false
boundary condition: true
initial amount: NaN
name: ADH6
has only substance units: false
is encoded by: hsa:130
is: P28332
type: Species

metaM CE1940 e
initial amount: NaN
constant: false
is: HMDB02329
is: SBO:0000247
type: Species
notes: FORMULA: C7H18N2O CHARGE: 2 INCHI: InChI=1/C7H16N2O/c8-4-3-6-9-5-1-2-7-10/h7,9H,1-6,8H2/p+1 EHMN_ABBREVIATION: CE1940
name: spermidine monoaldehyde 2
initial concentration: 1.0
boundary condition: false
has only substance units: false
is: CHEBI:30623

metaM CE2434 m
initial concentration: 1.0
has only substance units: false
name: trans,cis,cis-2,9,12-octadecatrienoyl-CoA
notes: FORMULA: C39H60N7O17P3S CHARGE: -4 INCHI: InChI=1/C39H64N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-30(48)67-23-22-41-29(47)20-21-42-37(51)34(50)39(2,3)25-60-66(57,58)63-65(55,56)59-24-28-33(62-64(52,53)54)32(49)38(61-28)46-27-45-31-35(40)43-26-44-36(31)46/h8-9,11-12,18-19,26-28,32-34,38,49-50H,4-7,10,13-17,20-25H2,1-3H3,(H,41,47)(H,42,51)(H,55,56)(H,57,58)(H2,40,43,44)(H2,52,53,54)/p-4/b9-8-,12-11-,19-18+/t28-,32+,33+,34u,38-/m0/s1 EHMN_ABBREVIATION: CE2434
constant: false
type: Species
is: CHEBI:57795
is: SBO:0000247
initial amount: NaN
boundary condition: false

metaR BTND1n
product: MODEL1310110045#
is version of: http://identifiers.org/ec-code/3.5.1.12
modifier: MODEL1310110045#
is: SBO:0000176
kinetic law: MODEL1310110045#
is described by: ECO:0000269
name: biotinidase (biotin), nuclear
type: Reaction
notes: GENE_ASSOCIATION: (686.1) SUBSYSTEM: Biotin metabolism EC Number: 3.5.1.12 Confidence Level: 4 AUTHORS: PMID:16011464,PMID:5867120,PMID:7758201,PMID:8593541 NOTES:IT
reversible: false
fast: false
reactant: MODEL1310110045#

http://identifiers.org/biomodels.db/MODEL1310110045#_1a900fcf_699c_4908_a071_5b958da39cb0
constant: false
has only substance units: false
name: SLC25A26
initial amount: NaN
boundary condition: true
initial concentration: NaN
type: Species
is: SBO:0000252
is: F8WAB8
is encoded by: hsa:115286

metaR r2328
is described by: ECO:0000000
is: SBO:0000185
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
reactant: MODEL1310110045#
kinetic law: MODEL1310110045#
type: Reaction
reversible: true
fast: false
product: MODEL1310110045#

metaM ptth c
is: HMDB03426
type: Species
is: CHEBI:16753
initial concentration: 1.0
notes: FORMULA: C11H22N2O4S CHARGE: 0 INCHI: InChI=1S/C11H22N2O4S/c1-11(2,7-14)9(16)10(17)13-4-3-8(15)12-5-6-18/h9,14,16,18H,3-7H2,1-2H3,(H,12,15)(H,13,17)/t9-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00554 EHMN_ABBREVIATION: C00831
has only substance units: false
name: pantetheine
is: SBO:0000247
boundary condition: false
constant: false
initial amount: NaN

metaR EX 34hpp
kinetic law: MODEL1310110045#
reactant: MODEL1310110045#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: Exchange of 3-(4-hydroxyphenyl)pyruvate
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110045#_4e7369e2_be7f_40d2_9364_b79c7b949c1a
has only substance units: false
constant: false
type: Species
is: P19440
name: GGT1
is encoded by: hsa:2678
boundary condition: true
is: SBO:0000252
initial concentration: NaN
initial amount: NaN

metaM HC02214 e
is: SBO:0000247
initial concentration: 1.0
initial amount: NaN
boundary condition: false
type: Species
constant: false
name: prostaglandin-f1alpha
has only substance units: false
notes: FORMULA: C20H35O5 CHARGE: -1 INCHI: InChI=1S/C20H36O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h12-13,15-19,21-23H,2-11,14H2,1H3,(H,24,25)/b13-12+/t15-,16+,17+,18-,19+/m0/s1
is: CHEBI:28852

metaR EX glyphe LPAREN e RPAREN
kinetic law: MODEL1310110045#
reactant: MODEL1310110045#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for glycylphenylalaine
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110045#_6b9bb1c4_d004_45cf_bb2b_63f01495ac09
boundary condition: true
constant: false
name: ADCY5
is encoded by: hsa:111
type: Species
initial amount: NaN
is: SBO:0000252
has only substance units: false
is: O95622
initial concentration: NaN

metaR FAOXC81C61m
kinetic law: MODEL1310110045#
product: MODEL1310110045#
reactant: MODEL1310110045#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C8:1-->C6:1)m
type: Reaction

metaM orot5p c
initial concentration: 1.0
has only substance units: false
initial amount: NaN
is: SBO:0000247
is: CHEBI:57538
type: Species
name: Orotidine 5'-phosphate
is: C01103
boundary condition: false
constant: false
notes: FORMULA: C10H10N2O11P CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00669 EHMN_ABBREVIATION: C01103
is: HMDB00218

metaR r2329
fast: false
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
is described by: ECO:0000000
reactant: MODEL1310110045#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
product: MODEL1310110045#
kinetic law: MODEL1310110045#
reversible: true
type: Reaction
is: SBO:0000185

metaM triodthy e
is: CHEBI:18258
name: 3,3',5-triiodo-L-thyronine
boundary condition: false
initial amount: NaN
is: SBO:0000247
notes: FORMULA: C15H12I3NO4 CHARGE: 0 INCHI: InChI=1S/C15H12I3NO4/c16-9-6-8(1-2-13(9)20)23-14-10(17)3-7(4-11(14)18)5-12(19)15(21)22/h1-4,6,12,20H,5,19H2,(H,21,22)/t12-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00943 EHMN_ABBREVIATION: C02465
constant: false
is: HMDB00265
has only substance units: false
type: Species
initial concentration: 1.0

metaR TCHOLAtx
reversible: true
is described by: ECO:0000000
reactant: MODEL1310110045#
name: bile acid intracellular transport
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: NOTES:unknown mechanism, however bile acids need to be secreted out of the cell NJ
product: MODEL1310110045#
is: SBO:0000185
type: Reaction
fast: false
kinetic law: MODEL1310110045#

http://identifiers.org/biomodels.db/MODEL1310110045#_fba9aede_1336_48c7_8ea4_79110cc296b7
boundary condition: true
has only substance units: false
type: Species
constant: false
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:146712
is: SBO:0000252
name: B3GNTL1
is: Q67FW5

metaR r0973
kinetic law: MODEL1310110045#
is described by: ECO:0000000
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:15975683 NOTES:
fast: false
type: Reaction
name: Facilitated diffusion
reactant: MODEL1310110045#
is: SBO:0000185
product: MODEL1310110045#

metaR ADNCYC
modifier: MODEL1310110045#
is described by: ECO:0000269
reversible: false
product: MODEL1310110045#
reactant: MODEL1310110045#
type: Reaction
is: SBO:0000176
notes: GENE_ASSOCIATION: (112.1) or (55811.1) or (109.1) or (112.2) or (114.1) or (108.1) or (113.1) or (107.1) or (196883.1) or (115.1) or (111.1) SUBSYSTEM: Nucleotide interconversion EC Number: 4.6.1.1 Confidence Level: 4 AUTHORS: PMID:10481931,PMID:11299302,PMID:11423534,PMID:11840511,PMID:12503609,PMID:12609998,PMID:12623444,PMID:1427768,PMID:14996950,PMID:15547246,PMID:7860067,PMID:7959689,PMID:8076676 NOTES:JLR
kinetic law: MODEL1310110045#
is version of: http://identifiers.org/ec-code/4.6.1.1
fast: false
name: adenylate cyclase

metaR P5CR
reversible: false
reactant: MODEL1310110045#
name: pyrroline-5-carboxylate reductase
fast: false
product: MODEL1310110045#
notes: GENE_ASSOCIATION: SUBSYSTEM: Arginine and Proline Metabolism EC Number: 1.5.1.2 Confidence Level: 4 AUTHORS: PMID: 11458019, Sareen S. Gropper, jack L. Smith, James L. Groff (2009) Wadaworth cengage learning, Advanced nutrition and human metabolism, 5th edition, page 194-196 NOTES:
kinetic law: MODEL1310110045#
is: SBO:0000176
type: Reaction
is described by: ECO:0000134

http://identifiers.org/biomodels.db/MODEL1310110045#_b05baf4b_8d53_43ab_ab6d_844dee6d5eb8
is encoded by: hsa:5143
name: PDE4C
is: SBO:0000252
type: Species
has only substance units: false
initial concentration: NaN
constant: false
boundary condition: true
is: Q7KYS4
initial amount: NaN

metaM CE1617 r
boundary condition: false
initial concentration: 1.0
notes: FORMULA: C20H27O2 CHARGE: -1 INCHI: InChI=1/C20H28O2/c1-15(8-6-9-16(2)14-19(21)22)11-12-18-17(3)10-7-13-20(18,4)5/h6,8-9,11-12,14H,7,10,13H2,1-5H3,(H,21,22)/p-1/b9-6+,12-11+,15-8-,16-14+ EHMN_ABBREVIATION: CE1617
type: Species
initial amount: NaN
is: HMDB01358
has only substance units: false
constant: false
is: SBO:0000247
is: CHEBI:17898
name: 9-cis-retinoate

http://identifiers.org/biomodels.db/MODEL1310110045#_f6178e86_6cd5_43b7_acc6_54555eb01937
is encoded by: hsa:491
boundary condition: true
constant: false
initial concentration: NaN
initial amount: NaN
type: Species
name: ATP2B2
is: Q4J699
is: SBO:0000252
has only substance units: false

metaR PGLer
fast: false
reactant: MODEL1310110045#
name: 6-phosphogluconolactonase, endoplasmic reticulum
type: Reaction
kinetic law: MODEL1310110045#
is described by: ECO:0000269
is: SBO:0000176
modifier: MODEL1310110045#
notes: GENE_ASSOCIATION: (9563.1) SUBSYSTEM: Pentose phosphate pathway EC Number: 3.1.1.31 Confidence Level: 4 AUTHORS: PMID:10349511,PMID:12831846,PMID:2156506 NOTES:SMP Net reaction same as described in Lehringer 334 NCD
is version of: http://identifiers.org/ec-code/1.1.1.47
reversible: false
product: MODEL1310110045#

metaM 3mob m
boundary condition: false
is: CHEBI:11851
constant: false
is: HMDB00019
notes: FORMULA: C5H7O3 CHARGE: -1 INCHI: InChI=1S/C5H8O3/c1-3(2)4(6)5(7)8/h3H,1-2H3,(H,7,8)/p-1 HEPATONET_1.0_ABBREVIATION: HC00139 EHMN_ABBREVIATION: C00141
type: Species
initial concentration: 1.0
name: 3-methyl-2-oxobutanoate
is: SBO:0000247
has only substance units: false
initial amount: NaN

metaM itacon m
has only substance units: false
notes: FORMULA: C5H4O4 CHARGE: -2 INCHI: InChI=1S/C5H6O4/c1-3(5(8)9)2-4(6)7/h1-2H2,(H,6,7)(H,8,9)/p-2 EHMN_ABBREVIATION: C00490
boundary condition: false
constant: false
is: SBO:0000247
initial concentration: 1.0
is: CHEBI:17240
type: Species
initial amount: NaN
is: HMDB02092
name: itaconate(2-)

http://identifiers.org/biomodels.db/MODEL1310110045#_1c8dbb05_b6e1_41cd_aee2_930cdffc4001
boundary condition: true
initial concentration: NaN
initial amount: NaN
constant: false
name: _AI818585_1_c
has only substance units: false
type: Species
is encoded by: hsa:AI818585
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110045#_76869916_c1eb_48bf_8cad_20cd6ae0af78
type: Species
has only substance units: false
initial concentration: NaN
boundary condition: true
is: SBO:0000252
name: FUCA1
initial amount: NaN
is encoded by: hsa:2517
is: P04066
constant: false

http://identifiers.org/biomodels.db/MODEL1310110045#_284d4b10_c452_4514_9893_07f9063b0135
is: SBO:0000252
initial amount: NaN
boundary condition: true
constant: false
name: ACOX1
initial concentration: NaN
type: Species
is encoded by: hsa:51
has only substance units: false
is: B4DK61

metaR GULNDer
kinetic law: MODEL1310110045#
notes: GENE_ASSOCIATION: SUBSYSTEM: Pentose phosphate pathway EC Number: 1.1.1.19 Confidence Level: 2 AUTHORS: PMID:9296457 NOTES:NCD
reversible: true
name: gulonate dehydrogenase, endoplasmic reticulum
is described by: ECO:0000000
product: MODEL1310110045#
is: SBO:0000176
reactant: MODEL1310110045#
type: Reaction
fast: false

metaR PCHOLPm hs
is: SBO:0000176
fast: false
product: MODEL1310110045#
reactant: MODEL1310110045#
name: choline phosphatase
is version of: http://identifiers.org/ec-code/3.1.4.4
kinetic law: MODEL1310110045#
is described by: ECO:0000269
type: Reaction
reversible: false
modifier: MODEL1310110045#
notes: GENE_ASSOCIATION: (5337.1) SUBSYSTEM: Glycerophospholipid metabolism EC Number: 3.1.4.4 Confidence Level: 4 AUTHORS: PMID:11481335,PMID:8530346 NOTES:NJ

metaR r1640
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reactant: MODEL1310110045#
is described by: ECO:0000000
fast: false
type: Reaction
kinetic law: MODEL1310110045#
is: SBO:0000185
modifier: MODEL1310110045#
reversible: true
product: MODEL1310110045#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1

metaM thbpt c
notes: FORMULA: C9H15N5O3 CHARGE: 0 INCHI: InChI=1S/C9H15N5O3/c1-3(15)6(16)4-2-11-7-5(12-4)8(17)14-9(10)13-7/h3-4,6,12,15-16H,2H2,1H3,(H4,10,11,13,14,17) HEPATONET_1.0_ABBREVIATION: HC00245 EHMN_ABBREVIATION: C00272
boundary condition: false
initial concentration: 1.0
name: 5,6,7,8-tetrahydrobiopterin
is: HMDB00027
is: CHEBI:15372
type: Species
initial amount: NaN
constant: false
is: SBO:0000247
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110045#_eed1d2b1_4e26_4fb2_8493_01da597a5486
name: COX4I2
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:84701
type: Species
is: Q96KJ9
initial concentration: NaN
boundary condition: true
has only substance units: false
constant: false

http://identifiers.org/biomodels.db/MODEL1310110045#_b3619e6c_2342_4c70_a108_96bed56e2a41
initial amount: NaN
constant: false
is encoded by: hsa:2542
initial concentration: NaN
has only substance units: false
type: Species
boundary condition: true
is: SBO:0000252
is: A8K0S7
name: SLC37A4

metaR RDH2a
type: Reaction
is version of: http://identifiers.org/ec-code/1.1.1.105
notes: GENE_ASSOCIATION: (195814.1) or (112724.1) or (145226.1) or (51109.1) or (57665.1) or (50700.1) SUBSYSTEM: Vitamin A metabolism EC Number: 1.1.1.105 Confidence Level: 4 AUTHORS: PMID:12226107,PMID:12372410,PMID:12435598,PMID:1503811,PMID:15258582,PMID:15322982 NOTES:IT
name: retinol dehydrogenase (9-cis,NADPH)
fast: false
product: MODEL1310110045#
is described by: ECO:0000269
modifier: MODEL1310110045#
is: SBO:0000176
kinetic law: MODEL1310110045#
reversible: true
reactant: MODEL1310110045#
is version of: http://identifiers.org/ec-code/1.1.1.300

http://identifiers.org/biomodels.db/MODEL1310110045#_b2097da9_9a2f_469e_a0bc_89a30f0d2437
initial amount: NaN
constant: false
initial concentration: NaN
type: Species
is: O95263
is encoded by: hsa:8622
has only substance units: false
is: SBO:0000252
boundary condition: true
name: PDE8B

metaR Htg
is described by: ECO:0000000
reversible: true
fast: false
type: Reaction
product: MODEL1310110045#
reactant: MODEL1310110045#
is: SBO:0000185
kinetic law: MODEL1310110045#
name: proton diffusion (Golgi)
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 2 AUTHORS: NOTES:

http://identifiers.org/biomodels.db/MODEL1310110045#_91e72f9c_1c78_47ab_9c4d_30383f40caa8
initial amount: NaN
is: SBO:0000252
initial concentration: NaN
has only substance units: false
boundary condition: true
is: Q9P0J0
type: Species
constant: false
is encoded by: hsa:51079
name: NDUFA13

http://identifiers.org/biomodels.db/MODEL1310110045#_c4c33893_792f_4f64_9ebb_c01a73ebfdbd
is: Q12882
name: DPYD
boundary condition: true
constant: false
is encoded by: hsa:1806
has only substance units: false
initial amount: NaN
initial concentration: NaN
is: SBO:0000252
type: Species

metaR CRNtHa
type: Reaction
name: L-carnitine outward transport (H+ antiport)
notes: GENE_ASSOCIATION: (6583.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12883891 NOTES:SAB H+ stoichiometry unknown
reversible: false
kinetic law: MODEL1310110045#
reactant: MODEL1310110045#
fast: false
modifier: MODEL1310110045#
is: SBO:0000185
product: MODEL1310110045#
is described by: ECO:0000269

metaR GALSIDEtl
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 1 AUTHORS: NOTES:unknown mechanism for transport - not known if it is energy dependent or not, recycling and IC transport is important to get it to other areas of the cell NJ
is: SBO:0000185
product: MODEL1310110045#
is described by: ECO:0000000
fast: false
kinetic law: MODEL1310110045#
type: Reaction
reactant: MODEL1310110045#
reversible: true
name: galactocerebroside intracellular transport

metaM cmpacna g
boundary condition: false
constant: false
is: HMDB01176
is: SBO:0000247
initial concentration: 1.0
name: CMP-N-acetyl-beta-neuraminate(2-)
is: CHEBI:57812
type: Species
initial amount: NaN
notes: FORMULA: C20H29N4O16P CHARGE: -2 INCHI: InChI=1S/C20H31N4O16P/c1-7(26)22-12-8(27)4-20(18(32)33,39-16(12)13(29)9(28)5-25)40-41(35,36)37-6-10-14(30)15(31)17(38-10)24-3-2-11(21)23-19(24)34/h2-3,8-10,12-17,25,27-31H,4-6H2,1H3,(H,22,26)(H,32,33)(H,35,36)(H2,21,23,34)/p-2/t8-,9+,10+,12+,13+,14+,15+,16+,17+,20+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00126 EHMN_ABBREVIATION: C00128
has only substance units: false

metaR r1642
is described by: ECO:0000000
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
fast: false
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
type: Reaction
is: SBO:0000185
kinetic law: MODEL1310110045#
reversible: true
reactant: MODEL1310110045#
modifier: MODEL1310110045#
product: MODEL1310110045#

metaM xol7ah2al m
boundary condition: false
has only substance units: false
name: 3alpha,7alpha-dihydroxy-5beta-cholestan-26-al
initial amount: NaN
type: Species
is: HMDB06894
notes: FORMULA: C27H46O3 CHARGE: 0 INCHI: InChI=1S/C27H46O3/c1-17(16-28)6-5-7-18(2)21-8-9-22-25-23(11-13-27(21,22)4)26(3)12-10-20(29)14-19(26)15-24(25)30/h16-25,29-30H,5-15H2,1-4H3/t17?,18-,19+,20-,21-,22+,23+,24-,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01454 EHMN_ABBREVIATION: C05445
is: CHEBI:27428
initial concentration: 1.0
is: SBO:0000247
constant: false

metaR r0129
is version of: http://identifiers.org/ec-code/2.7.1.40
name: gamma-glutamyltranspeptidase Glutathione metabolism EC:3.4.11.4
reactant: MODEL1310110045#
notes: GENE_ASSOCIATION: (H77542.1) or (5313.1) or (5315.1) SUBSYSTEM: Glutathione metabolism EC Number: 3.4.11.4 Confidence Level: 0 AUTHORS: PMID:1968061,PMID:3511062 NOTES:
is described by: ECO:0000000
fast: false
kinetic law: MODEL1310110045#
type: Reaction
is: SBO:0000176
product: MODEL1310110045#
modifier: MODEL1310110045#
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110045#_69a0793c_e8e7_4e9b_be45_e36901409aab
is: SBO:0000252
type: Species
has only substance units: false
is encoded by: hsa:4126
name: MANBA
initial amount: NaN
is: O00462
initial concentration: NaN
boundary condition: true
constant: false

http://identifiers.org/biomodels.db/MODEL1310110045#_2a021b94_14b7_4b66_8c87_d61ee7ce3af0
is: SBO:0000297
initial concentration: NaN
type: Species
has only substance units: false
has part: P55084
initial amount: NaN
has part: E9KL44
constant: false
is encoded by: hsa:3032
boundary condition: true
name: HADHA:HADHB
is encoded by: hsa:3030

metaM 4abut n
has only substance units: false
is: C00334
initial amount: NaN
constant: false
notes: FORMULA: C4H9NO2 CHARGE: 0
name: 4-Aminobutanoate
boundary condition: false
is: SBO:0000247
is: HMDB00112
initial concentration: 1.0
type: Species

metaR RE2973C
notes: GENE_ASSOCIATION: (5290.1) or (5291.1) or (5294.1) or (5289.1) or (5286.1) or (5287.1) or (5288.1) SUBSYSTEM: Phosphatidylinositol phosphate metabolism EC Number: 2.7.1.137 Confidence Level: 0 AUTHORS: PMID:10358929,PMID:11493657,PMID:9043658,PMID:9211928 NOTES:
reversible: true
is version of: http://identifiers.org/ec-code/2.7.1.154
is version of: http://identifiers.org/ec-code/2.7.1.137
name: RE2973
is version of: http://identifiers.org/ec-code/2.7.1.153
fast: false
kinetic law: MODEL1310110045#
reactant: MODEL1310110045#
type: Reaction
product: MODEL1310110045#
is version of: http://identifiers.org/ec-code/2.7.11.1
is described by: ECO:0000000
is: SBO:0000176
modifier: MODEL1310110045#

metaR r1641
reversible: true
modifier: MODEL1310110045#
is: SBO:0000185
is described by: ECO:0000000
kinetic law: MODEL1310110045#
reactant: MODEL1310110045#
product: MODEL1310110045#
type: Reaction
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
fast: false
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110045#_79f13769_57bf_4e0e_b734_fd0d935d8938
type: Species
is: Q1ET61
is encoded by: hsa:6818
boundary condition: true
name: SULT1A3
has only substance units: false
constant: false
initial amount: NaN
initial concentration: NaN
is: SBO:0000252

metaR PI345P3P
reactant: MODEL1310110045#
is version of: http://identifiers.org/ec-code/3.1.3.67
name: phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase
fast: false
notes: GENE_ASSOCIATION: (5728.1) SUBSYSTEM: Inositol phosphate metabolism EC Number: 3.1.3.67 Confidence Level: 4 AUTHORS: PMID:11463863 NOTES:NCD
kinetic law: MODEL1310110045#
modifier: MODEL1310110045#
reversible: false
type: Reaction
product: MODEL1310110045#
is described by: ECO:0000000
is: SBO:0000176

metaM gcald c
is: CHEBI:17071
has only substance units: false
is: HMDB03344
notes: FORMULA: C2H4O2 CHARGE: 0 INCHI: InChI=1S/C2H4O2/c3-1-2-4/h1,4H,2H2 EHMN_ABBREVIATION: C00266
is: SBO:0000247
constant: false
initial amount: NaN
boundary condition: false
initial concentration: 1.0
name: glycolaldehyde
type: Species

metaM mescon m
notes: FORMULA: C5H4O4 CHARGE: -2 INCHI: InChI=1S/C5H6O4/c1-3(5(8)9)2-4(6)7/h2H,1H3,(H,6,7)(H,8,9)/p-2/b3-2+
boundary condition: false
type: Species
name: Mesaconate
has only substance units: false
initial concentration: 1.0
is: CHEBI:36986
initial amount: NaN
is: HMDB00749
constant: false
is: SBO:0000247

metaM ksi deg15 l
notes: FORMULA: C160H257N11O140S8 CHARGE: -8
initial amount: NaN
is: SBO:0000247
constant: false
is: CHEBI:12936
is: HMDB00143
name: keratan sulfate I, degradation product 15
type: Species
initial concentration: 1.0
has only substance units: false
boundary condition: false

metaM hpyr c
initial amount: NaN
constant: false
name: 3-hydroxypyruvate
is: SBO:0000247
notes: FORMULA: C3H3O4 CHARGE: -1 INCHI: InChI=1S/C3H4O4/c4-1-2(5)3(6)7/h4H,1H2,(H,6,7)/p-1 HEPATONET_1.0_ABBREVIATION: HC00163 EHMN_ABBREVIATION: C00168
is: CHEBI:17180
initial concentration: 1.0
type: Species
has only substance units: false
boundary condition: false
is: HMDB01352

http://identifiers.org/biomodels.db/MODEL1310110045#_35f9bb94_e815_4ed4_a525_f893aad4addc
is encoded by: hsa:4720
initial amount: NaN
name: NDUFS2
has only substance units: false
initial concentration: NaN
boundary condition: true
is: B7Z792
constant: false
type: Species
is: SBO:0000252

metaR r1644
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is described by: ECO:0000000
reversible: true
type: Reaction
is: SBO:0000185
modifier: MODEL1310110045#
product: MODEL1310110045#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
fast: false
kinetic law: MODEL1310110045#
reactant: MODEL1310110045#

http://identifiers.org/biomodels.db/MODEL1310110045#_afaabc9d_a5fd_4932_b8ed_21d4b03ad5e8
initial amount: NaN
boundary condition: true
is: SBO:0000252
has only substance units: false
constant: false
is encoded by: hsa:80308
type: Species
name: FLAD1
initial concentration: NaN

metaM 4abut m
name: 4-Aminobutanoate
initial amount: NaN
is: HMDB00112
has only substance units: false
is: CHEBI:16865
notes: FORMULA: C4H9NO2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00284 EHMN_ABBREVIATION: C00334
constant: false
type: Species
is: C00334
initial concentration: 1.0
is: SBO:0000247
boundary condition: false

metaR KHK
reversible: false
is version of: http://identifiers.org/ec-code/2.7.1.3
notes: GENE_ASSOCIATION: (3795.1) or (3795.2) SUBSYSTEM: Fructose and mannose metabolism EC Number: 2.7.1.3 Confidence Level: 0 AUTHORS: NOTES:NCD
kinetic law: MODEL1310110045#
name: ketohexokinase
is: SBO:0000176
modifier: MODEL1310110045#
product: MODEL1310110045#
is described by: ECO:0000000
fast: false
reactant: MODEL1310110045#
type: Reaction

metaR EX CE5854 LPAREN e RPAREN
kinetic law: MODEL1310110045#
reactant: MODEL1310110045#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: gama-CEHC-glucuronide exchange
type: Reaction

metaM tcynt e
type: Species
constant: false
boundary condition: false
notes: FORMULA: CNS CHARGE: -1 INCHI: InChI=1S/CHNS/c2-1-3/h3H/p-1 EHMN_ABBREVIATION: C01755
name: thiocyanate
has only substance units: false
is: CHEBI:18022
is: HMDB01453
is: SBO:0000247
initial concentration: 1.0
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110045#_72312582_35a2_4eba_81a4_870ccf99e639
is encoded by: hsa:2805
boundary condition: true
is: P17174
type: Species
initial concentration: NaN
name: GOT1
initial amount: NaN
has only substance units: false
constant: false
is: SBO:0000252

metaR C226COAtx
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: NOTES:interaction between peroxisomes and ER (some enzymes on the outer membrane) NJ
reversible: true
is described by: ECO:0000000
name: fatty acid intracellular transport
kinetic law: MODEL1310110045#
product: MODEL1310110045#
type: Reaction
fast: false
reactant: MODEL1310110045#
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110045#_870d92ec_9315_421d_91fd_e08101ce5c2b
initial amount: NaN
initial concentration: NaN
name: NDUFB8
constant: false
has only substance units: false
type: Species
is: SBO:0000252
is: O95169
boundary condition: true
is encoded by: hsa:4714

http://identifiers.org/biomodels.db/MODEL1310110045#_cfb685da_e70f_4d5a_a948_cf63cae33aff
is: SBO:0000252
initial amount: NaN
name: GALT
has only substance units: false
boundary condition: true
constant: false
is encoded by: hsa:2592
type: Species
is: B4E097
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110045#_ada9e5da_d237_415b_96a1_13c3cef03a1a
initial amount: NaN
type: Species
initial concentration: NaN
name: OGDHL
has only substance units: false
is encoded by: hsa:55753
constant: false
is: SBO:0000252
boundary condition: true
is: Q9ULD0

metaR r1643
is: SBO:0000185
product: MODEL1310110045#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is described by: ECO:0000000
fast: false
reversible: true
kinetic law: MODEL1310110045#
type: Reaction
reactant: MODEL1310110045#
modifier: MODEL1310110045#
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110045#_04567c91_cac0_4e6a_a305_efb83f5c4512
constant: false
boundary condition: true
name: _HG2846_HT2983_1_c
type: Species
initial amount: NaN
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:HG2846-HT2983
has only substance units: false

metaR MACACI
modifier: MODEL1310110045#
product: MODEL1310110045#
name: maleylacetoacetate isomerase
fast: false
kinetic law: MODEL1310110045#
reversible: false
is version of: http://identifiers.org/ec-code/2.5.1.18
is: SBO:0000176
is described by: ECO:0000269
type: Reaction
notes: GENE_ASSOCIATION: (2954.1) or (2954.3) or (2954.2) SUBSYSTEM: Tyrosine metabolism EC Number: 5.2.1.2 Confidence Level: 4 AUTHORS: PMID:10373324 NOTES:NCD
reactant: MODEL1310110045#

metaR HXPRT
modifier: MODEL1310110045#
type: Reaction
fast: false
product: MODEL1310110045#
kinetic law: MODEL1310110045#
is version of: http://identifiers.org/ec-code/2.4.2.8
reversible: false
notes: GENE_ASSOCIATION: (3251.1) SUBSYSTEM: Nucleotide salvage pathway EC Number: 2.4.2.8 Confidence Level: 4 AUTHORS: PMID:3008106,PMID:6853490 NOTES:Guanine (see GUAPRT) and 6-mercaptopurine can replace hypoxanthine
is described by: ECO:0000269
reactant: MODEL1310110045#
is: SBO:0000176
name: hypoxanthine phosphoribosyltransferase (Hypoxanthine)

metaR EX s2l2n2m2masn LPAREN e RPAREN
kinetic law: MODEL1310110045#
reactant: MODEL1310110045#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: de-Fuc form of PA6 exchange
type: Reaction

metaR HMGCOASim
is described by: ECO:0000269
product: MODEL1310110045#
kinetic law: MODEL1310110045#
is: SBO:0000176
name: Hydroxymethylglutaryl CoA synthase (ir)
reactant: MODEL1310110045#
reversible: false
type: Reaction
is version of: http://identifiers.org/ec-code/2.3.3.10
notes: GENE_ASSOCIATION: (3158.1) SUBSYSTEM: Cholesterol metabolism EC Number: 4.1.3.5 Confidence Level: 4 AUTHORS: PMID:7893153 NOTES:NCD New assignment: EC-2.3.3.10 EC-4.1.3.5 (created 1961, deleted 2002). Enzyme Commission mitochondrial enzyme NJ Made irreversible to match KEGG data for S. aureus
modifier: MODEL1310110045#
fast: false

metaR FATP1t
is described by: ECO:0000269
is: SBO:0000185
type: Reaction
name: fatty acid electroneutral transport
reactant: MODEL1310110045#
reversible: true
notes: GENE_ASSOCIATION: (376497.2) or (10999.1) or (376497.1) or (11000.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12856180,PMID:15522816,PMID:9878842 NOTES:electroneutral transport NJ
product: MODEL1310110045#
modifier: MODEL1310110045#
fast: false
kinetic law: MODEL1310110045#

metaM CE5101 m
initial concentration: 1.0
has only substance units: false
boundary condition: false
notes: FORMULA: C11H15O16P2R2 CHARGE: -3 EHMN_ABBREVIATION: CE5101
initial amount: NaN
is: SBO:0000247
type: Species
is: CHEBI:57795
name: 1-phosphatidyl-1D-myo-inositol 5-phosphate(3-)
constant: false

metaR FAOXC185C164m
kinetic law: MODEL1310110045#
product: MODEL1310110045#
reactant: MODEL1310110045#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C18:5-->C16:4)m
type: Reaction

metaR r1646
type: Reaction
is: SBO:0000185
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reversible: true
product: MODEL1310110045#
modifier: MODEL1310110045#
fast: false
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reactant: MODEL1310110045#
kinetic law: MODEL1310110045#
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110045#_fdeb8160_6d0a_4503_9c46_c9bf33af000d
initial concentration: NaN
name: LDHD
boundary condition: true
has only substance units: false
initial amount: NaN
is encoded by: hsa:197257
constant: false
is: Q86WU2
is: SBO:0000252
type: Species

metaR KHK2
modifier: MODEL1310110045#
kinetic law: MODEL1310110045#
is version of: http://identifiers.org/ec-code/2.7.1.3
is described by: ECO:0000269
reversible: false
type: Reaction
fast: false
reactant: MODEL1310110045#
notes: GENE_ASSOCIATION: (3795.1) or (3795.2) SUBSYSTEM: Glyoxylate and dicarboxylate metabolism EC Number: 2.7.1.3 Confidence Level: 4 AUTHORS: PMID:2996495,PMID:6284103,PMID:6298387 NOTES:NCD
is: SBO:0000176
product: MODEL1310110045#
name: ketohexokinase (D-xylulose)

metaM tcynt c
initial amount: NaN
notes: FORMULA: CNS CHARGE: -1 INCHI: InChI=1S/CHNS/c2-1-3/h3H/p-1 EHMN_ABBREVIATION: C01755
type: Species
boundary condition: false
has only substance units: false
name: thiocyanate
constant: false
is: CHEBI:18022
is: HMDB01453
initial concentration: 1.0
is: SBO:0000247

metaM cmpacna c
constant: false
is: HMDB01176
name: CMP-N-acetyl-beta-neuraminate(2-)
is: SBO:0000247
has only substance units: false
boundary condition: false
initial concentration: 1.0
initial amount: NaN
is: CHEBI:57812
type: Species
notes: FORMULA: C20H29N4O16P CHARGE: -2 INCHI: InChI=1S/C20H31N4O16P/c1-7(26)22-12-8(27)4-20(18(32)33,39-16(12)13(29)9(28)5-25)40-41(35,36)37-6-10-14(30)15(31)17(38-10)24-3-2-11(21)23-19(24)34/h2-3,8-10,12-17,25,27-31H,4-6H2,1H3,(H,22,26)(H,32,33)(H,35,36)(H2,21,23,34)/p-2/t8-,9+,10+,12+,13+,14+,15+,16+,17+,20+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00126 EHMN_ABBREVIATION: C00128

metaM ksii core2 pre9 g
is: CHEBI:28067
type: Species
initial concentration: 1.0
constant: false
name: keratan sulfate II biosynthesis, precursor 9
notes: FORMULA: C75H120N6O59S2X CHARGE: -3
has only substance units: false
initial amount: NaN
is: SBO:0000247
boundary condition: false

metaM 5eipencoa m
has only substance units: false
boundary condition: false
is: SBO:0000247
initial concentration: 1.0
constant: false
initial amount: NaN
name: 5,8,11,14,17-eicosapentenoylcoa
type: Species
notes: FORMULA: C41H60N7O17P3S CHARGE: -4
is: HMDB06294

metaR r1645
is described by: ECO:0000000
product: MODEL1310110045#
type: Reaction
fast: false
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reversible: true
reactant: MODEL1310110045#
kinetic law: MODEL1310110045#
is: SBO:0000185
modifier: MODEL1310110045#
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110045#_db362f19_77a5_400a_a12a_8e5f79a62fe7
boundary condition: true
initial concentration: NaN
name: SLC25A26
is: SBO:0000252
constant: false
is: Q70HW3
initial amount: NaN
has only substance units: false
type: Species
is encoded by: hsa:115286

metaM xoltriol c
boundary condition: false
is: HMDB01457
type: Species
initial concentration: 1.0
is: CHEBI:16496
notes: FORMULA: C27H48O3 CHARGE: 0 INCHI: InChI=1S/C27H48O3/c1-16(2)7-6-8-17(3)20-9-10-21-25-22(15-24(30)27(20,21)5)26(4)12-11-19(28)13-18(26)14-23(25)29/h16-25,28-30H,6-15H2,1-5H3/t17-,18+,19-,20-,21+,22+,23-,24+,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01463 EHMN_ABBREVIATION: C05454
has only substance units: false
name: 5beta-cholestane-3alpha,7alpha,12alpha-triol
is: SBO:0000247
constant: false
initial amount: NaN

metaR RE2655R
name: RE2655
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Vitamin A metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:9647871 NOTES:
product: MODEL1310110045#
kinetic law: MODEL1310110045#
is described by: ECO:0000000
type: Reaction
reversible: true
reactant: MODEL1310110045#
fast: false

metaR EX glyc LPAREN e RPAREN
kinetic law: MODEL1310110045#
reactant: MODEL1310110045#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Glycerol exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110045#_80401b6e_3fe5_4f65_a369_45a7e7e0d102
initial amount: NaN
has only substance units: false
type: Species
is: P26439
name: HSD3B2
is: SBO:0000252
boundary condition: true
constant: false
is encoded by: hsa:3284
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110045#_309b216a_2d98_4fdc_b486_b5ea38038116
has only substance units: false
type: Species
name: SULT1A1
constant: false
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:6817
boundary condition: true
initial amount: NaN

metaR DM ethamp r
kinetic law: MODEL1310110045#
reactant: MODEL1310110045#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 0 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: false
name: Ethanolamine phosphate demand
type: Reaction

metaR DHCHOLESTANATEtm
reactant: MODEL1310110045#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: PMID:12840657 NOTES:cholesterol precursor, transport by "diffusion" -> actually beleived to be flip-flop mechanism (PMID: 12840657). NJ
product: MODEL1310110045#
name: lipid, flip-flop intracellular transport
fast: false
kinetic law: MODEL1310110045#
is: SBO:0000185
reversible: true
type: Reaction

metaR OMHPALTD
kinetic law: MODEL1310110045#
product: MODEL1310110045#
reactant: MODEL1310110045#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: transport of w-hydroxypalmitic acid by diffusion
type: Reaction

metaR FAOXC61m
kinetic law: MODEL1310110045#
product: MODEL1310110045#
reactant: MODEL1310110045#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: isomerization(C6:1)m
type: Reaction

metaR THYMDt1
product: MODEL1310110045#
reversible: false
reactant: MODEL1310110045#
type: Reaction
notes: GENE_ASSOCIATION: (3177.1) or (2030.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10722669,PMID:12838422,PMID:9693094 NOTES:TDV
name: thymd transport
is: SBO:0000185
fast: false
is described by: ECO:0000269
kinetic law: MODEL1310110045#
modifier: MODEL1310110045#

metaR M4MPDOL Lter
product: MODEL1310110045#
is: SBO:0000185
kinetic law: MODEL1310110045#
type: Reaction
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: N-glycan synthesis EC Number: Confidence Level: 0 AUTHORS: NOTES:
is described by: ECO:0000000
reactant: MODEL1310110045#
reversible: false
name: m4mpdol flippase

http://identifiers.org/biomodels.db/MODEL1310110045#_42740d76_16e4_472f_ade0_b678dd04b163
boundary condition: true
name: ENTPD8
initial amount: NaN
is: SBO:0000252
is encoded by: hsa:377841
is: Q5MY95
initial concentration: NaN
type: Species
constant: false
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110045#_b2d89500_a96f_4469_a1ee_7a9c0aab6e39
type: Species
is: SBO:0000252
initial concentration: NaN
name: DUOX2
is encoded by: hsa:50506
constant: false
boundary condition: true
has only substance units: false
initial amount: NaN
is: Q9NRD8

http://identifiers.org/biomodels.db/MODEL1310110045#_1dae5d48_5827_41a3_a268_a75acdfa00d8
type: Species
initial amount: NaN
boundary condition: true
has only substance units: false
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:3037
constant: false
is: Q92819
name: HAS2

metaM HC01712 m
constant: false
type: Species
is: CHEBI:28391
name: S-Glutaryldihydrolipoamide
initial amount: NaN
initial concentration: 1.0
has only substance units: false
is: SBO:0000247
notes: FORMULA: C13H22NO4S2 CHARGE: -1 INCHI: InChI=1S/C13H23NO4S2/c14-11(15)5-2-1-4-10(19)8-9-20-13(18)7-3-6-12(16)17/h10,19H,1-9H2,(H2,14,15)(H,16,17) EHMN_ABBREVIATION: C06157
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110045#_7f37535a_e591_4e92_b0c0_a5da86882d74
is encoded by: hsa:4718
is: Q549M5
is: SBO:0000252
type: Species
boundary condition: true
constant: false
initial amount: NaN
initial concentration: NaN
name: NDUFC2
has only substance units: false

metaR AG13T17g
reactant: MODEL1310110045#
type: Reaction
notes: GENE_ASSOCIATION: (10678.2) or (11041.1) or (10678.1) or (374907.2) or (93010.1) or (374907.1) or (146712.1) or (79369.1) or (10331.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.149 Confidence Level: 4 AUTHORS: PMID:10747980,PMID:11042166,PMID:12061784,PMID:12512857,PMID:15560372,PMID:15620693,PMID:9405606 NOTES:NCD
kinetic law: MODEL1310110045#
modifier: MODEL1310110045#
product: MODEL1310110045#
fast: false
is described by: ECO:0000000
name: N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase, Golgi apparatus
is version of: http://identifiers.org/ec-code/2.4.1.149
reversible: false
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110045#_57edfb2c_295f_4d22_a374_a00ca74feb29
is: SBO:0000252
type: Species
name: SLC22A2
initial amount: NaN
constant: false
initial concentration: NaN
is encoded by: hsa:6582
has only substance units: false
boundary condition: true

metaR r0403
name: L-Tryptophan,tetrahydrobiopterin:oxygen oxidoreductase (5-hydroxylating) Tryptophan metabolism EC:1.14.16.4
reactant: MODEL1310110045#
is: SBO:0000176
fast: false
kinetic law: MODEL1310110045#
reversible: true
type: Reaction
product: MODEL1310110045#
modifier: MODEL1310110045#
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/1.2.4.4
notes: GENE_ASSOCIATION: (594.1) or (641649.1) SUBSYSTEM: Tetrahydrobiopterin metabolism EC Number: 1.14.16.4 Confidence Level: 0 AUTHORS: NOTES:

metaM man c
has only substance units: false
boundary condition: false
initial concentration: 1.0
is: C00159
type: Species
constant: false
is: CHEBI:16024
is: HMDB00169
is: SBO:0000247
initial amount: NaN
notes: FORMULA: C6H12O6 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00154 EHMN_ABBREVIATION: C00159
name: D-Mannose

http://identifiers.org/biomodels.db/MODEL1310110045#_4aa04f17_bcaf_4d98_826b_a8800f1a0bd8
is: SBO:0000252
type: Species
is: Q9BY07
boundary condition: true
initial amount: NaN
is encoded by: hsa:57835
name: SLC4A5
initial concentration: NaN
has only substance units: false
constant: false

metaR FATP2t
notes: GENE_ASSOCIATION: (376497.1) or (376497.2) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12856180,PMID:15522816 NOTES:electroneutral transport NJ
type: Reaction
is described by: ECO:0000269
reversible: true
product: MODEL1310110045#
reactant: MODEL1310110045#
is: SBO:0000185
name: fatty acid electroneutral transport
fast: false
modifier: MODEL1310110045#
kinetic law: MODEL1310110045#

metaR OCCOAtx
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: NOTES:interaction between peroxisomes and ER (some enzymes on the outer membrane) NJ
is: SBO:0000185
name: fatty acid intracellular transport
type: Reaction
reversible: true
kinetic law: MODEL1310110045#
fast: false
reactant: MODEL1310110045#
product: MODEL1310110045#
is described by: ECO:0000000

metaR A MANASEly
modifier: MODEL1310110045#
notes: GENE_ASSOCIATION: (4125.1) SUBSYSTEM: N-glycan degradation EC Number: 3.2.1.24 Confidence Level: 0 AUTHORS: PMID:8910458 NOTES:NCD
product: MODEL1310110045#
reversible: false
kinetic law: MODEL1310110045#
type: Reaction
name: alpha-mannosidase, lysosomal
is version of: http://identifiers.org/ec-code/3.2.1.24
fast: false
is described by: ECO:0000000
reactant: MODEL1310110045#
is: SBO:0000176

metaR PRISTtx
fast: false
type: Reaction
product: MODEL1310110045#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 0 AUTHORS: NOTES:Mechanism not known, see PMID 11591435 for justification. NJ
name: prist peroxisomal transport
kinetic law: MODEL1310110045#
reversible: true
reactant: MODEL1310110045#
is described by: ECO:0000000
is: SBO:0000185

metaR r0812
kinetic law: MODEL1310110045#
type: Reaction
is: SBO:0000185
is version of: http://identifiers.org/ec-code/2.3.1.85
reactant: MODEL1310110045#
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/2.3.1.41
reversible: true
name: Mitochondrial Carrier (MC) TCDB:2.A.29.20.1
fast: false
modifier: MODEL1310110045#
notes: GENE_ASSOCIATION: (AA177072.1) or (2194.1) or (54995.1) SUBSYSTEM: Purine catabolism EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:18406340,PMID:9759482 NOTES:
product: MODEL1310110045#

metaR EX cbasp LPAREN e RPAREN
kinetic law: MODEL1310110045#
reactant: MODEL1310110045#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: Exchange of N-carbamoyl-L-aspartate
type: Reaction

metaR ORNt4m
fast: false
product: MODEL1310110045#
is: SBO:0000185
type: Reaction
reactant: MODEL1310110045#
name: ornithine mitochondrial transport exchange with citruline
kinetic law: MODEL1310110045#
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (10166.1) or (83884.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172 NOTES:TDV (ornithine carrier)
reversible: true
modifier: MODEL1310110045#

metaR NACHEX22ly
notes: GENE_ASSOCIATION: (3074.1) or (3073.1 and 3074.1) or (3073.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.52 Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12706724,PMID:8993162 NOTES:NCD
fast: false
kinetic law: MODEL1310110045#
is version of: http://identifiers.org/ec-code/3.2.1.52
product: MODEL1310110045#
name: beta-N-acetylhexosaminidase, lysosomal
modifier: MODEL1310110045#
reactant: MODEL1310110045#
is: SBO:0000176
is described by: ECO:0000000
reversible: false
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110045#_eed22a57_5377_46d1_bccb_aff3cf90c0bf
is: P20933
constant: false
name: AGA
initial concentration: NaN
has only substance units: false
is encoded by: hsa:175
type: Species
initial amount: NaN
is: SBO:0000252
boundary condition: true

metaR RE0830N
reversible: true
notes: GENE_ASSOCIATION: (5092.1) or (84105.1) SUBSYSTEM: Tetrahydrobiopterin metabolism EC Number: 4.2.1.96 Confidence Level: 0 AUTHORS: PMID:10727395,PMID:1355046,PMID:1988938 NOTES:
is version of: http://identifiers.org/ec-code/4.2.1.96
is described by: ECO:0000000
type: Reaction
product: MODEL1310110045#
name: RE0830
fast: false
modifier: MODEL1310110045#
kinetic law: MODEL1310110045#
is: SBO:0000176
reactant: MODEL1310110045#

metaM nrvnccoa x
name: nervonyl coenzyme A
constant: false
notes: FORMULA: C45H76N7O17P3S CHARGE: -4 INCHI: InChI=1/C45H80N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-24-25-36(54)73-29-28-47-35(53)26-27-48-43(57)40(56)45(2,3)31-66-72(63,64)69-71(61,62)65-30-34-39(68-70(58,59)60)38(55)44(67-34)52-33-51-37-41(46)49-32-50-42(37)52/h11-12,32-34,38-40,44,55-56H,4-10,13-31H2,1-3H3,(H,47,53)(H,48,57)(H,61,62)(H,63,64)(H2,46,49,50)(H2,58,59,60)/b12-11-/t34-,38-,39-,40?,44-/m1/s1
initial concentration: 1.0
is: SBO:0000247
boundary condition: false
has only substance units: false
type: Species
is: C16532
initial amount: NaN

metaR FRDPtc
reactant: MODEL1310110045#
fast: false
is described by: ECO:0000000
reversible: true
type: Reaction
name: lipid, flip-flop intracellular transport
product: MODEL1310110045#
kinetic law: MODEL1310110045#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: PMID:12840657 NOTES:cholesterol precursor, transport by "diffusion" -> actually beleived to be flip-flop mechanism (PMID: 12840657). See also Krisans (PMID: 14713247, PMID: 12121718) for synthesis of cholesterol pathway (why FRDP needs to be transported between ER and peroxisome) NJ
is: SBO:0000185

metaM xoldioloneh c
boundary condition: false
name: 7alpha,12alpha-dihydroxy-5beta-cholestan-3-one
type: Species
initial concentration: 1.0
is: SBO:0000247
notes: FORMULA: C27H46O3 CHARGE: 0 INCHI: InChI=1S/C27H46O3/c1-16(2)7-6-8-17(3)20-9-10-21-25-22(15-24(30)27(20,21)5)26(4)12-11-19(28)13-18(26)14-23(25)29/h16-18,20-25,29-30H,6-15H2,1-5H3/t17-,18+,20-,21+,22+,23-,24+,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01462 EHMN_ABBREVIATION: C05453
is: HMDB06887
initial amount: NaN
has only substance units: false
constant: false
is: CHEBI:2288

metaR RE1532M
notes: GENE_ASSOCIATION: (10449.1) or (3032.1) or (3030.1) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.16 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:7775433,PMID:7923814,PMID:9568246,PMID:9920399 NOTES:
is version of: http://identifiers.org/ec-code/4.2.1.17
type: Reaction
is version of: http://identifiers.org/ec-code/2.3.1.16
fast: false
modifier: MODEL1310110045#
product: MODEL1310110045#
name: RE1532
is described by: ECO:0000000
reversible: true
is: SBO:0000176
kinetic law: MODEL1310110045#
reactant: MODEL1310110045#

metaR PE HSter
type: Reaction
is described by: ECO:0000000
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: PMID:10856717,PMID:15311932 NOTES:
name: phosphatidylethanolamine scramblase
reactant: MODEL1310110045#
reversible: true
product: MODEL1310110045#
kinetic law: MODEL1310110045#
fast: false

http://identifiers.org/biomodels.db/MODEL1310110045#_4e92be4a_fa8a_407a_8b7f_bb221093ceb7
name: SLC25A16
initial amount: NaN
is: SBO:0000252
is: P16260
has only substance units: false
boundary condition: true
constant: false
initial concentration: NaN
type: Species
is encoded by: hsa:8034

metaR DNDPt9m
fast: false
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (60386.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:11226231 NOTES:IT
kinetic law: MODEL1310110045#
reversible: false
name: dADP transport via dTDP antiport
is: SBO:0000185
product: MODEL1310110045#
reactant: MODEL1310110045#
type: Reaction
modifier: MODEL1310110045#

http://identifiers.org/biomodels.db/MODEL1310110045#_f23036e2_9347_4237_88da_aa5ba7461235
name: CDIPT
type: Species
constant: false
is encoded by: hsa:10423
has only substance units: false
boundary condition: true
initial concentration: NaN
initial amount: NaN
is: O14735
is: SBO:0000252

metaM ser D c
initial amount: NaN
notes: FORMULA: C3H7NO3 CHARGE: 0 INCHI: InChI=1S/C3H7NO3/c4-2(1-5)3(6)7/h2,5H,1,4H2,(H,6,7)/t2-/m1/s1
type: Species
name: D-serine
initial concentration: 1.0
is: HMDB03406
is: SBO:0000247
constant: false
boundary condition: false
has only substance units: false
is: CHEBI:16523

metaM ksi pre3 g
is: C00130
is: CHEBI:58053
initial concentration: 1.0
type: Species
notes: FORMULA: C93H152N6O67X CHARGE: -1
is: HMDB00175
constant: false
name: keratan sulfate I biosynthesis, precursor 3
initial amount: NaN
boundary condition: false
has only substance units: false
is: SBO:0000247

metaR RE2974C
product: MODEL1310110045#
name: RE2974
kinetic law: MODEL1310110045#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.7.1.149
reactant: MODEL1310110045#
is version of: http://identifiers.org/ec-code/2.7.1.68
notes: GENE_ASSOCIATION: (8395.1) or (23396.1) or (5305.1) or (8396.1) or (79837.1) or (8394.1) SUBSYSTEM: Phosphatidylinositol phosphate metabolism EC Number: 2.7.1.68 Confidence Level: 0 AUTHORS: PMID:10231032,PMID:10358929,PMID:11493657,PMID:9211928 NOTES:
modifier: MODEL1310110045#
reversible: true
fast: false
type: Reaction
is described by: ECO:0000000

metaR r0408
product: MODEL1310110045#
reversible: true
is version of: http://identifiers.org/ec-code/1.4.3.5
is: SBO:0000176
modifier: MODEL1310110045#
kinetic law: MODEL1310110045#
type: Reaction
name: ATP:Sedoheptulose 7-phosphate 1-phosphotransferase EC:2.7.1.11
reactant: MODEL1310110045#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (AI934540.1) or (55163.1) or (W74642.1) SUBSYSTEM: Unassigned EC Number: 2.7.1.11 Confidence Level: 0 AUTHORS: PMID:4084320,PMID:4272358 NOTES:
fast: false

metaM itaccoa m
boundary condition: false
type: Species
constant: false
initial concentration: 1.0
is: HMDB03377
name: itaconyl-CoA(5-)
notes: FORMULA: C26H35N7O19P3S CHARGE: -5 INCHI: InChI=1S/C26H40N7O19P3S/c1-13(25(39)40)8-16(35)56-7-6-28-15(34)4-5-29-23(38)20(37)26(2,3)10-49-55(46,47)52-54(44,45)48-9-14-19(51-53(41,42)43)18(36)24(50-14)33-12-32-17-21(27)30-11-31-22(17)33/h11-12,14,18-20,24,36-37H,1,4-10H2,2-3H3,(H,28,34)(H,29,38)(H,39,40)(H,44,45)(H,46,47)(H2,27,30,31)(H2,41,42,43)/p-5/t14-,18-,19-,20+,24-/m1/s1 EHMN_ABBREVIATION: C00531
has only substance units: false
is: SBO:0000247
initial amount: NaN
is: CHEBI:57381

metaM arachdcrn c
is: CHEBI:57387
type: Species
constant: false
is: SBO:0000247
is: HMDB01322
initial concentration: 1.0
initial amount: NaN
boundary condition: false
notes: FORMULA: C27H45NO4 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC12236
name: C20:4 carnitine
has only substance units: false

metaR THYOXt2
reversible: true
kinetic law: MODEL1310110045#
notes: GENE_ASSOCIATION: (6567.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12871948,PMID:7981683 NOTES:NJ
name: T4 transport via facilitated diffusion
is: SBO:0000185
fast: false
product: MODEL1310110045#
is described by: ECO:0000269
reactant: MODEL1310110045#
type: Reaction
modifier: MODEL1310110045#

metaR DURAD2
is: SBO:0000176
is described by: ECO:0000269
fast: false
reactant: MODEL1310110045#
kinetic law: MODEL1310110045#
name: dihydrothymin dehydrogenase (NADP)
reversible: true
is version of: http://identifiers.org/ec-code/1.3.1.2
modifier: MODEL1310110045#
type: Reaction
product: MODEL1310110045#
notes: GENE_ASSOCIATION: (1806.1) SUBSYSTEM: Pyrimidine catabolism EC Number: 1.3.1.2 Confidence Level: 4 AUTHORS: PMID:1512248,PMID:8221682 NOTES:_01-26-05 IT based on Lu et al., JBC,1992,24,17102-17109

metaR EX maltttr LPAREN e RPAREN
kinetic law: MODEL1310110045#
reactant: MODEL1310110045#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Maltotetraose exchange
type: Reaction

metaR CHOLt4
kinetic law: MODEL1310110045#
reactant: MODEL1310110045#
reversible: true
modifier: MODEL1310110045#
fast: false
notes: GENE_ASSOCIATION: (60482.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:11027560,PMID:11068039,PMID:12675135 NOTES:NCD
is described by: ECO:0000269
is: SBO:0000185
product: MODEL1310110045#
name: choline, sodium cotransport
type: Reaction

metaM xylu D c
initial amount: NaN
constant: false
notes: FORMULA: C5H10O5 CHARGE: 0 INCHI: InChI=1S/C5H10O5/c6-1-3(8)5(10)4(9)2-7/h3,5-8,10H,1-2H2/t3-,5+/m1/s1
is: SBO:0000247
name: D-xylulose
has only substance units: false
is: CHEBI:17140
boundary condition: false
type: Species
is: HMDB01644
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110045#_3760e635_736a_48a1_807c_866271844338
is encoded by: hsa:5151
is: SBO:0000252
initial amount: NaN
initial concentration: NaN
name: PDE8A
has only substance units: false
boundary condition: true
constant: false
type: Species

metaR RE3421R
product: MODEL1310110045#
fast: false
reactant: MODEL1310110045#
kinetic law: MODEL1310110045#
reversible: true
is: SBO:0000176
name: RE3421
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Eicosanoid metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:11786541,PMID:8521498 NOTES:
type: Reaction

metaR DOLPMT L
reversible: false
type: Reaction
notes: GENE_ASSOCIATION: (54344.2 and 8818.1 and 8813.1) or (8818.2 and 54344.1 and 8813.1) or (8818.1 and 54344.1 and 8813.1) or (54344.2 and 8818.2 and 8813.1) SUBSYSTEM: N-glycan synthesis EC Number: 2.4.1.83 Confidence Level: 0 AUTHORS: PMID:11420690 NOTES:NCD
fast: false
is version of: http://identifiers.org/ec-code/2.4.1.83
product: MODEL1310110045#
reactant: MODEL1310110045#
modifier: MODEL1310110045#
is: SBO:0000176
is described by: ECO:0000000
kinetic law: MODEL1310110045#
name: Dolichyl-phosphate D-mannosyltransferase (liver)

metaM xoltetrol m
has only substance units: false
initial amount: NaN
type: Species
is: SBO:0000247
name: 5beta-cholestane-3alpha,7alpha,12alpha,26-tetrol
is: CHEBI:17278
notes: FORMULA: C27H48O4 CHARGE: 0 INCHI: InChI=1S/C27H48O4/c1-16(15-28)6-5-7-17(2)20-8-9-21-25-22(14-24(31)27(20,21)4)26(3)11-10-19(29)12-18(26)13-23(25)30/h16-25,28-31H,5-15H2,1-4H3/t16?,17-,18+,19-,20-,21+,22+,23-,24+,25+,26+,27-/m1/s1 EHMN_ABBREVIATION: C05446
boundary condition: false
constant: false
initial concentration: 1.0
is: HMDB01231

metaR r1377
name: S-(hydroxymethyl)glutathione synthase Methane metabolism EC:4.4.1.22
reactant: MODEL1310110045#
fast: false
reversible: true
type: Reaction
is: SBO:0000176
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 4.4.1.22 Confidence Level: 0 AUTHORS: NOTES:
kinetic law: MODEL1310110045#
product: MODEL1310110045#

metaM 4hpro LT m
is: CHEBI:18095
boundary condition: false
notes: FORMULA: C5H9NO3 CHARGE: 0 INCHI: InChI=1S/C5H9NO3/c7-3-1-4(5(8)9)6-2-3/h3-4,6-7H,1-2H2,(H,8,9)/t3-,4+/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00690
initial concentration: 1.0
constant: false
name: trans-4-hydroxy-L-proline
is: SBO:0000247
has only substance units: false
is: HMDB00725
initial amount: NaN
type: Species

http://identifiers.org/biomodels.db/MODEL1310110045#_655e4ee7_2d01_487e_826a_d1737095718a
is encoded by: hsa:3945
type: Species
has part: P07195
name: LDHA:LDHB
initial concentration: NaN
has only substance units: false
is: SBO:0000297
has part: P00338
initial amount: NaN
constant: false
boundary condition: true
is encoded by: hsa:3939

http://identifiers.org/biomodels.db/MODEL1310110045#_f68a3218_ec62_4865_82fb_76d1f303bcf5
is: SBO:0000252
type: Species
is: Q9NRZ5
boundary condition: true
is encoded by: hsa:56895
name: AGPAT4
initial concentration: NaN
has only substance units: false
constant: false
initial amount: NaN

metaM man g
initial amount: NaN
is: HMDB00169
type: Species
constant: false
initial concentration: 1.0
name: D-mannose
is: CHEBI:16024
notes: FORMULA: C6H12O6 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00154 EHMN_ABBREVIATION: C00159
is: SBO:0000247
has only substance units: false
boundary condition: false

metaR r0407
is: SBO:0000176
reversible: true
notes: GENE_ASSOCIATION: (AI934540.1) or (55163.1) or (W74642.1) SUBSYSTEM: Unassigned EC Number: 4.1.2.13 Confidence Level: 0 AUTHORS: PMID:10214945,PMID:2198022,PMID:4052378,PMID:4084320,PMID:6952783 NOTES:
modifier: MODEL1310110045#
type: Reaction
kinetic law: MODEL1310110045#
product: MODEL1310110045#
name: Sedoheptulose 1,7-bisphosphate D-glyceraldehyde-3-phosphate-lyase Carbon fixation EC:4.1.2.13
fast: false
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/1.4.3.5
reactant: MODEL1310110045#

http://identifiers.org/biomodels.db/MODEL1310110045#_2e483d3e_949f_4423_be4c_c0c67fc0551c
boundary condition: true
is: SBO:0000252
type: Species
initial amount: NaN
constant: false
initial concentration: NaN
is: Q86VV3
has only substance units: false
is encoded by: hsa:953
name: ENTPD1

metaR PYRt2r
notes: GENE_ASSOCIATION: (9123.1) or (9194.1) or (6566.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10510291,PMID:11101640,PMID:12739169,PMID:7835905,PMID:8476015,PMID:9425115,PMID:9508842,PMID:9649795,PMID:9786900,PMID:9824713 NOTES:JLR
product: MODEL1310110045#
type: Reaction
is described by: ECO:0000269
is: SBO:0000185
fast: false
name: pyruvate reversible transport via proton symport
kinetic law: MODEL1310110045#
reactant: MODEL1310110045#
reversible: true
modifier: MODEL1310110045#

metaR TYMSFt
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 1 AUTHORS: NOTES:SAB excretion of tyramine sulfate
is described by: ECO:0000000
fast: false
kinetic law: MODEL1310110045#
reversible: false
reactant: MODEL1310110045#
product: MODEL1310110045#
name: Tyramine O-sulfate transport (diffusion)
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110045#_d23c7ab2_0905_421e_9b4c_1505920001b1
name: SULT1A3
is encoded by: hsa:6818
is: SBO:0000252
boundary condition: true
constant: false
initial concentration: NaN
type: Species
initial amount: NaN
has only substance units: false

metaR EX imp LPAREN e RPAREN
kinetic law: MODEL1310110045#
reactant: MODEL1310110045#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: IMP exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110045#_2af34a40_ad93_4b48_94d7_9d084309007a
name: ENPP3
initial amount: NaN
has only substance units: false
initial concentration: NaN
boundary condition: true
constant: false
is: SBO:0000252
type: Species
is encoded by: hsa:5169
is: Q308M7

metaR r1378
product: MODEL1310110045#
type: Reaction
kinetic law: MODEL1310110045#
name: S-(hydroxymethyl)glutathione dehydrogenase Methane metabolism EC:1.1.1.284
is: SBO:0000176
reactant: MODEL1310110045#
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 1.1.1.284 Confidence Level: 0 AUTHORS: PMID:18288723 NOTES:
is described by: ECO:0000000
fast: false
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110045#_7e3eefc1_de8b_439d_8a98_0ea23f6fd60d
name: PEMT
initial concentration: NaN
is: SBO:0000252
boundary condition: true
initial amount: NaN
has only substance units: false
type: Species
constant: false
is encoded by: hsa:10400

http://identifiers.org/biomodels.db/MODEL1310110045#_d5e0dda7_1c53_4f61_94df_79a88923d1f5
type: Species
is: SBO:0000252
is encoded by: hsa:55825
initial amount: NaN
constant: false
has only substance units: false
boundary condition: true
name: PECR
initial concentration: NaN
is: Q9BY49

http://identifiers.org/biomodels.db/MODEL1310110045#_43fcb4db_17ab_4308_9d59_4817d10fc69a
is encoded by: hsa:2936
type: Species
is: SBO:0000252
constant: false
is: P00390
boundary condition: true
has only substance units: false
initial concentration: NaN
initial amount: NaN
name: GSR

metaM ksi pre16 g
boundary condition: false
constant: false
has only substance units: false
is: SBO:0000247
initial amount: NaN
type: Species
notes: FORMULA: C157H253N11O124S4X CHARGE: -5
is: C00130
is: CHEBI:58053
is: HMDB00175
initial concentration: 1.0
name: keratan sulfate I biosynthesis, precursor 16

http://identifiers.org/biomodels.db/MODEL1310110045#_b2eeb602_cb34_47f1_835f_6b482e4087cc
constant: false
name: GPX3
is encoded by: hsa:2878
boundary condition: true
has only substance units: false
is: P22352
type: Species
initial concentration: NaN
initial amount: NaN
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110045#_7242e337_fc3a_4274_99ea_5d3dfe798c65
name: ACSL6
initial concentration: NaN
has only substance units: false
type: Species
is: B2RB13
is encoded by: hsa:23305
constant: false
is: SBO:0000252
initial amount: NaN
boundary condition: true

metaR RE2677E
type: Reaction
reversible: false
reactant: MODEL1310110045#
kinetic law: MODEL1310110045#
notes: GENE_ASSOCIATION: SUBSYSTEM: Glycosphingolipid metabolism EC Number: 2.4.1.47 Confidence Level: 0 AUTHORS: PMID:423891,PMID:9125199 NOTES:IT - fixed proton
name: RE2677
product: MODEL1310110045#
is: SBO:0000176
fast: false
is described by: ECO:0000000

metaM HC02020 r
name: Cholesterol-ester-palm
type: Species
initial concentration: 1.0
notes: FORMULA: C43H76O2 CHARGE: 0 INCHI: InChI=1S/C43H76O2/c1-7-8-9-10-11-12-13-14-15-16-17-18-19-23-41(44)45-36-28-30-42(5)35(32-36)24-25-37-39-27-26-38(34(4)22-20-21-33(2)3)43(39,6)31-29-40(37)42/h24,33-34,36-40H,7-23,25-32H2,1-6H3/t34-,36+,37+,38-,39+,40+,42+,43-/m1/s1
constant: false
is: CHEBI:3663
boundary condition: false
initial amount: NaN
is: SBO:0000247
has only substance units: false

metaR SADT
name: sulfate adenylyltransferase
is version of: http://identifiers.org/ec-code/2.7.1.25
modifier: MODEL1310110045#
reactant: MODEL1310110045#
reversible: false
notes: GENE_ASSOCIATION: (9060.1) or (9061.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.7.4 Confidence Level: 4 AUTHORS: PMID:11931637,PMID:12716056 NOTES:
fast: false
is: SBO:0000176
type: Reaction
product: MODEL1310110045#
is described by: ECO:0000269
kinetic law: MODEL1310110045#

metaM pchol hs m
is: CHEBI:16110
notes: FORMULA: C8H18NO4PFULLRCO2FULLR2CO2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC02000 EHMN_ABBREVIATION: C00157
boundary condition: false
type: Species
initial amount: NaN
name: Phosphatidylcholine
initial concentration: 1.0
has only substance units: false
constant: false
is: SBO:0000247

metaM man e
initial amount: NaN
name: D-Mannose
is: HMDB00169
type: Species
initial concentration: 1.0
constant: false
notes: FORMULA: C6H12O6 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00154 EHMN_ABBREVIATION: C00159
is: C00159
is: CHEBI:16024
has only substance units: false
boundary condition: false
is: SBO:0000247

metaM ser D e
has only substance units: false
is: HMDB03406
boundary condition: false
is: CHEBI:16523
notes: FORMULA: C3H7NO3 CHARGE: 0 INCHI: InChI=1S/C3H7NO3/c4-2(1-5)3(6)7/h2,5H,1,4H2,(H,6,7)/t2-/m1/s1
initial amount: NaN
type: Species
initial concentration: 1.0
constant: false
name: D-serine
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110045#_2de1cdf7_240d_499b_9a0d_c20df12a0557
type: Species
has only substance units: false
initial concentration: NaN
is encoded by: hsa:7001
boundary condition: true
initial amount: NaN
name: PRDX2
constant: false
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110045#_10237623_92de_45bd_b275_2dcfcdc208a8
boundary condition: true
name: AMY2B
is: SBO:0000252
is encoded by: hsa:280
initial amount: NaN
is: P19961
constant: false
initial concentration: NaN
has only substance units: false
type: Species

metaR r1920
name: Y+LAT2 Utilized transport
reversible: false
kinetic law: MODEL1310110045#
type: Reaction
modifier: MODEL1310110045#
reactant: MODEL1310110045#
is: SBO:0000185
product: MODEL1310110045#
fast: false
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is described by: ECO:0000000

metaR RE1903R
type: Reaction
is: SBO:0000176
is described by: ECO:0000000
fast: false
reactant: MODEL1310110045#
notes: GENE_ASSOCIATION: SUBSYSTEM: Vitamin A metabolism EC Number: 1.2.1.36 Confidence Level: 0 AUTHORS: PMID:10559215,PMID:11007799 NOTES:
kinetic law: MODEL1310110045#
product: MODEL1310110045#
name: RE1903
reversible: true

metaR 2HBt2
modifier: MODEL1310110045#
fast: false
product: MODEL1310110045#
notes: GENE_ASSOCIATION: (9123.1) or (9194.1) or (6566.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10510291,PMID:11101640,PMID:12739169,PMID:7835905,PMID:8476015,PMID:9425115,PMID:9508842,PMID:9649795,PMID:9786900,PMID:9824713 NOTES:NCD
name: 2-hydroxybutyrate cotransport with proton
kinetic law: MODEL1310110045#
is described by: ECO:0000269
reversible: true
reactant: MODEL1310110045#
is: SBO:0000185
type: Reaction

metaR r0818
kinetic law: MODEL1310110045#
type: Reaction
product: MODEL1310110045#
fast: false
is: SBO:0000185
reversible: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Pyruvate metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:12657464,PMID:14519855,PMID:16194150 NOTES:
is described by: ECO:0000000
name: Transport reaction
reactant: MODEL1310110045#

metaR FAOXC143C123m
kinetic law: MODEL1310110045#
product: MODEL1310110045#
reactant: MODEL1310110045#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C14:3-->C12:3)m
type: Reaction

metaM HC01223 m
initial amount: NaN
notes: FORMULA: C25H38N7O18P3S CHARGE: -4 INCHI: InChI=1S/C25H42N7O18P3S/c1-13(8-33)24(38)54-7-6-27-15(34)4-5-28-22(37)19(36)25(2,3)10-47-53(44,45)50-52(42,43)46-9-14-18(49-51(39,40)41)17(35)23(48-14)32-12-31-16-20(26)29-11-30-21(16)32/h11-14,17-19,23,33,35-36H,4-10H2,1-3H3,(H,27,34)(H,28,37)(H,42,43)(H,44,45)(H2,26,29,30)(H2,39,40,41)/p-4/t13?,14-,17-,18-,19+,23-/m1/s1 EHMN_ABBREVIATION: C04047
has only substance units: false
initial concentration: 1.0
is: CHEBI:57340
is: SBO:0000247
boundary condition: false
name: 3-hydroxy-2-methylpropanoyl-CoA(4-)
type: Species
constant: false

metaM glyclt x
is: HMDB00115
initial concentration: 1.0
initial amount: NaN
name: glycolate
is: SBO:0000247
constant: false
type: Species
boundary condition: false
has only substance units: false
notes: FORMULA: C2H3O3 CHARGE: -1 INCHI: InChI=1S/C2H4O3/c3-1-2(4)5/h3H,1H2,(H,4,5)/p-1 EHMN_ABBREVIATION: C00160
is: CHEBI:29805

metaR RE0830C
reversible: true
reactant: MODEL1310110045#
is: SBO:0000176
product: MODEL1310110045#
is described by: ECO:0000000
fast: false
kinetic law: MODEL1310110045#
name: RE0830
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Tetrahydrobiopterin metabolism EC Number: 4.2.1.96 Confidence Level: 0 AUTHORS: PMID:10727395,PMID:1355046,PMID:1988938 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110045#_87611fc7_c415_4528_939c_edc204af6c9c
type: Species
is: SBO:0000252
is: P00439
name: PAH
has only substance units: false
initial amount: NaN
constant: false
is encoded by: hsa:5053
initial concentration: NaN
boundary condition: true

metaM thbpt4acam n
initial concentration: 1.0
has only substance units: false
name: 4a-hydroxytetrahydrobiopterin
initial amount: NaN
notes: FORMULA: C9H15N5O4 CHARGE: 0 INCHI: InChI=1S/C9H15N5O4/c1-3(15)5(16)4-2-11-6-9(18,14-4)7(17)13-8(10)12-6/h3-5,14-16,18H,2H2,1H3,(H3,10,11,12,13,17) EHMN_ABBREVIATION: CE1951
is: SBO:0000247
type: Species
boundary condition: false
is: HMDB02281
is: CHEBI:15374
constant: false

metaR r2327
is described by: ECO:0000000
product: MODEL1310110045#
type: Reaction
fast: false
is: SBO:0000185
kinetic law: MODEL1310110045#
reactant: MODEL1310110045#
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
reversible: true

metaM mthgxl c
initial amount: NaN
constant: false
is: CHEBI:17158
initial concentration: 1.0
is: SBO:0000247
notes: FORMULA: C3H4O2 CHARGE: 0 INCHI: InChI=1S/C3H4O2/c1-3(5)2-4/h2H,1H3 HEPATONET_1.0_ABBREVIATION: HC00425 EHMN_ABBREVIATION: C00546
is: HMDB01167
type: Species
has only substance units: false
name: methylglyoxal
boundary condition: false

metaR r0817
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.3.2
type: Reaction
reversible: true
reactant: MODEL1310110045#
modifier: MODEL1310110045#
kinetic law: MODEL1310110045#
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/2.3.1.85
product: MODEL1310110045#
fast: false
is version of: http://identifiers.org/ec-code/2.3.1.41
is: SBO:0000185
notes: GENE_ASSOCIATION: (AA177072.1) or (2194.1) or (54995.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:10049700,PMID:10072483,PMID:10391915,PMID:10574970,PMID:11004451,PMID:11311135,PMID:11389679,PMID:11557028,PMID:11564694,PMID:11742812,PMID:11827462,PMID:12117417,PMID:12824232,PMID:12883891,PMID:14574404,PMID:14770310,PMID:15465786,PMID:16082501,PMID:16288981,PMID:17466261,PMID:1904693,PMID:4424190,PMID:6432599,PMID:7690540,PMID:7718542,PMID:9751058,PMID:9759917,PMID:9868191 NOTES:

metaR FK
kinetic law: MODEL1310110045#
fast: false
is version of: http://identifiers.org/ec-code/2.7.1.52
type: Reaction
name: Fucokinase
notes: GENE_ASSOCIATION: (197258.1) SUBSYSTEM: Fructose and mannose metabolism EC Number: 2.7.1.52 Confidence Level: 0 AUTHORS: NOTES:kh 1/6/03 NCD
reactant: MODEL1310110045#
reversible: false
is: SBO:0000176
product: MODEL1310110045#
modifier: MODEL1310110045#
is described by: ECO:0000000

metaR S6T12g
is: SBO:0000176
name: galactose/N-acetylglucosamine 6-O-sulfotransferase, Golgi apparatus
reactant: MODEL1310110045#
is described by: ECO:0000000
kinetic law: MODEL1310110045#
type: Reaction
product: MODEL1310110045#
notes: GENE_ASSOCIATION: (23563.1) or (9435.1) or (10164.1) or (4166.1) or (23563.2) SUBSYSTEM: Keratan sulfate synthesis EC Number: Confidence Level: 4 AUTHORS: PMID:10330415,PMID:10491328,PMID:10913333,PMID:11278593,PMID:12403612,PMID:12855678,PMID:9722682 NOTES:NCD
fast: false
modifier: MODEL1310110045#
reversible: false

metaR r1943
kinetic law: MODEL1310110045#
product: MODEL1310110045#
reversible: false
name: Y+LAT2 Utilized transport
reactant: MODEL1310110045#
type: Reaction
fast: false
modifier: MODEL1310110045#
is: SBO:0000185
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:

metaR CYTK5n
is: SBO:0000176
name: cytidylate kinase (CMP),nuclear
is version of: http://identifiers.org/ec-code/2.7.4.14
reversible: true
kinetic law: MODEL1310110045#
modifier: MODEL1310110045#
type: Reaction
product: MODEL1310110045#
fast: false
reactant: MODEL1310110045#
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544 NOTES:

metaR RE2677G
type: Reaction
kinetic law: MODEL1310110045#
name: RE2677
notes: GENE_ASSOCIATION: SUBSYSTEM: Glycosphingolipid metabolism EC Number: 2.4.1.47 Confidence Level: 0 AUTHORS: PMID:423891,PMID:9125199 NOTES:
reversible: false
fast: false
is: SBO:0000176
is described by: ECO:0000000
product: MODEL1310110045#
reactant: MODEL1310110045#

metaR SERDGLNexR
notes: GENE_ASSOCIATION: (56301.1) and (6520.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10734121,PMID:10863037,PMID:14770310 NOTES:
is: SBO:0000185
reversible: true
modifier: MODEL1310110045#
type: Reaction
name: D-Serine/Glutamine reversible exchange
is described by: ECO:0000304
kinetic law: MODEL1310110045#
product: MODEL1310110045#
reactant: MODEL1310110045#
fast: false

http://identifiers.org/biomodels.db/MODEL1310110045#_f4d21286_e7c3_4774_b8bb_c91b62bb2490
has only substance units: false
is: P59796
boundary condition: true
initial amount: NaN
is encoded by: hsa:257202
constant: false
initial concentration: NaN
is: SBO:0000252
type: Species
name: GPX6

http://identifiers.org/biomodels.db/MODEL1310110045#_3b2d8b66_eeae_4edf_a1d8_02cb6948f866
initial amount: NaN
constant: false
boundary condition: true
is: O43286
is encoded by: hsa:9334
name: B4GALT5
is: SBO:0000252
type: Species
initial concentration: NaN
has only substance units: false

metaM taur e
is: SBO:0000247
boundary condition: false
initial concentration: 1.0
name: Taurine
is: HMDB00251
is: CHEBI:3544
is: C00245
type: Species
constant: false
has only substance units: false
notes: FORMULA: C2H7NO3S CHARGE: 0
initial amount: NaN

metaM gsn e
initial concentration: 1.0
has only substance units: false
initial amount: NaN
is: C00387
boundary condition: false
is: HMDB00133
is: SBO:0000247
type: Species
name: Guanosine
constant: false
is: CHEBI:16750
notes: FORMULA: C10H13N5O5 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00322 EHMN_ABBREVIATION: C00387

metaR r2326
type: Reaction
reversible: true
product: MODEL1310110045#
kinetic law: MODEL1310110045#
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
fast: false
is: SBO:0000185
is described by: ECO:0000000
reactant: MODEL1310110045#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:

metaM malthp e
has only substance units: false
is: http://identifiers.org/pubchem.compound/5041
notes: FORMULA: C42H72O36 CHARGE: 0 INCHI: InChI=1/C42H72O36/c43-1-8-15(50)16(51)24(59)37(67-8)74-31-10(3-45)69-39(26(61)18(31)53)76-33-12(5-47)71-41(28(63)20(33)55)78-35-14(7-49)72-42(29(64)22(35)57)77-34-13(6-48)70-40(27(62)21(34)56)75-32-11(4-46)68-38(25(60)19(32)54)73-30-9(2-44)66-36(65)23(58)17(30)52/h8-65H,1-7H2/t8-,9-,10-,11-,12-,13-,14-,15+,16+,17-,18-,19-,20-,21-,22-,23+,24+,25+,26+,27+,28+,29+,30+,31+,32+,33+,34+,35+,36u,37+,38+,39+,40+,41+,42+/m1/s1 EHMN_ABBREVIATION: CE2837
constant: false
is: SBO:0000247
boundary condition: false
name: maltoheptaose
type: Species
initial amount: NaN
is: C01936
initial concentration: 1.0

metaM HC02024 r
type: Species
is: SBO:0000247
has only substance units: false
boundary condition: false
is: CHEBI:41509
name: Cholesterol-ester-lin
constant: false
notes: FORMULA: C45H76O2 CHARGE: 0 INCHI: InChI=1S/C45H76O2/c1-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-25-43(46)47-38-30-32-44(5)37(34-38)26-27-39-41-29-28-40(36(4)24-22-23-35(2)3)45(41,6)33-31-42(39)44/h11-12,14-15,26,35-36,38-42H,7-10,13,16-25,27-34H2,1-6H3/b12-11-,15-14-/t36-,38+,39+,40-,41+,42+,44+,45-/m1/s1
initial concentration: 1.0
initial amount: NaN

metaR r1944
name: Y+LAT2 Utilized transport
is described by: ECO:0000000
modifier: MODEL1310110045#
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is: SBO:0000185
type: Reaction
fast: false
product: MODEL1310110045#
reversible: false
reactant: MODEL1310110045#
kinetic law: MODEL1310110045#

metaR S6T8g
is described by: ECO:0000000
kinetic law: MODEL1310110045#
reactant: MODEL1310110045#
notes: GENE_ASSOCIATION: (23563.2) or (9435.1) or (23563.1) or (10164.1) or (4166.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: Confidence Level: 4 AUTHORS: PMID:10330415,PMID:10491328,PMID:10913333,PMID:11278593,PMID:12403612,PMID:12855678,PMID:9722682 NOTES:NCD
reversible: false
fast: false
modifier: MODEL1310110045#
product: MODEL1310110045#
is: SBO:0000176
type: Reaction
name: galactose/N-acetylglucosamine 6-O-sulfotransferase, Golgi apparatus

http://identifiers.org/biomodels.db/MODEL1310110045#_0ec37d2d_2037_4174_bdad_3479d6687e24
initial amount: NaN
is encoded by: hsa:3176
initial concentration: NaN
name: HNMT
constant: false
is: SBO:0000252
boundary condition: true
type: Species
has only substance units: false
is: P50135

metaR DOLPGT2 Ler
modifier: MODEL1310110045#
is described by: ECO:0000000
name: dolichyl-phosphate-glucose-glycolipid alpha-glucosyltransferase (liver)
reversible: false
kinetic law: MODEL1310110045#
is: SBO:0000176
type: Reaction
reactant: MODEL1310110045#
notes: GENE_ASSOCIATION: (79053.1) or (79053.3) or (79053.2) SUBSYSTEM: N-glycan synthesis EC Number: Confidence Level: 0 AUTHORS: NOTES:EC 2.4.1.- NCD
is version of: http://identifiers.org/ec-code/2.4.1.265
fast: false
product: MODEL1310110045#

metaR AACOAT
type: Reaction
reversible: true
is: SBO:0000176
notes: GENE_ASSOCIATION: (65985.1) SUBSYSTEM: Propanoate metabolism EC Number: 6.2.1.16 Confidence Level: 4 AUTHORS: PMID:12623130 NOTES:also EC 2.8.3.8 NCD
is described by: ECO:0000269
product: MODEL1310110045#
is version of: http://identifiers.org/ec-code/6.2.1.16
reactant: MODEL1310110045#
name: Acetoacetyl-CoA:acetate CoA-transferase
modifier: MODEL1310110045#
kinetic law: MODEL1310110045#
fast: false

metaR EX HC00229 LPAREN e RPAREN
kinetic law: MODEL1310110045#
reactant: MODEL1310110045#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of Isomaltose
type: Reaction

metaR r2325
is described by: ECO:0000000
kinetic law: MODEL1310110045#
product: MODEL1310110045#
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
fast: false
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
is: SBO:0000185
reactant: MODEL1310110045#
reversible: true

metaM cs c deg5 l
is: SBO:0000247
constant: false
name: chondroitin sulfate C (GalNAc6S-GlcA), degradation product 5
boundary condition: false
type: Species
has only substance units: false
notes: FORMULA: C23H36O24S CHARGE: -2
initial concentration: 1.0
initial amount: NaN
is: CHEBI:15936

metaR r2324
is described by: ECO:0000000
reactant: MODEL1310110045#
is: SBO:0000185
reversible: true
product: MODEL1310110045#
fast: false
kinetic law: MODEL1310110045#
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
type: Reaction

metaM 7dhf m
constant: false
initial amount: NaN
is: SBO:0000247
boundary condition: false
name: heptaglutamyl folate (DHF)
initial concentration: 1.0
is: HMDB06559
type: Species
notes: FORMULA: C49H55N13O24 CHARGE: -8 INCHI: InChI=1/C54H68N14O27/c55-24(5-12-31(69)70)39(83)52(49(92)93,40(84)25(56)6-13-32(71)72)53(41(85)26(57)7-14-33(73)74,42(86)27(58)8-15-34(75)76)54(43(87)28(59)9-16-35(77)78,50(94)95-48(91)30(61)11-18-37(81)82)68(47(90)29(60)10-17-36(79)80)46(89)21-1-3-22(4-2-21)63-19-23-20-64-44-38(65-23)45(88)67-51(62)66-44/h1-4,20,24-30,63H,5-19,55-61H2,(H,69,70)(H,71,72)(H,73,74)(H,75,76)(H,77,78)(H,79,80)(H,81,82)(H,92,93)(H3,62,64,66,67,88)/t24-,25-,26-,27-,28-,29-,30-,54?/m0/s1
has only substance units: false

metaR GALASE17ly
type: Reaction
reversible: false
modifier: MODEL1310110045#
reactant: MODEL1310110045#
kinetic law: MODEL1310110045#
fast: false
product: MODEL1310110045#
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) or (5476.1) and (2720.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.23 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.1.6.4
is version of: http://identifiers.org/ec-code/3.2.1.23
is version of: http://identifiers.org/ec-code/3.4.16.5
is described by: ECO:0000000
name: beta-galactosidase, lysosomal
is version of: http://identifiers.org/ec-code/3.2.1.18

metaR KSItly
fast: false
is: SBO:0000185
kinetic law: MODEL1310110045#
name: keratan sulfate I transport, extracellular to lysosome
reactant: MODEL1310110045#
reversible: false
type: Reaction
is described by: ECO:0000000
product: MODEL1310110045#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 2 AUTHORS: NOTES:NCD

metaR DOPAtu
modifier: MODEL1310110045#
kinetic law: MODEL1310110045#
name: Dopamine uniport
product: MODEL1310110045#
reversible: true
is described by: ECO:0000269
reactant: MODEL1310110045#
fast: false
is: SBO:0000185
notes: GENE_ASSOCIATION: (6581.1) or (6582.2) or (6582.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12883891 NOTES:SAB electrogenic, Na indepdendent & rev NJ
type: Reaction

metaM CE2435 m
name: trans,cis-deca-2,4-dienoyl-CoA
notes: FORMULA: C31H46N7O17P3S CHARGE: -4 INCHI: InChI=1/C31H50N7O17P3S/c1-4-5-6-7-8-9-10-11-22(40)59-15-14-33-21(39)12-13-34-29(43)26(42)31(2,3)17-52-58(49,50)55-57(47,48)51-16-20-25(54-56(44,45)46)24(41)30(53-20)38-19-37-23-27(32)35-18-36-28(23)38/h8-11,18-20,24-26,30,41-42H,4-7,12-17H2,1-3H3,(H,33,39)(H,34,43)(H,47,48)(H,49,50)(H2,32,35,36)(H2,44,45,46)/p-4/b9-8-,11-10+/t20-,24+,25+,26u,30-/m0/s1 EHMN_ABBREVIATION: CE2435
boundary condition: false
initial concentration: 1.0
initial amount: NaN
type: Species
is: CHEBI:57795
has only substance units: false
constant: false
is: SBO:0000247

metaM gsn c
is: HMDB00133
is: C00387
type: Species
is: SBO:0000247
initial amount: NaN
has only substance units: false
constant: false
is: CHEBI:16750
name: Guanosine
boundary condition: false
notes: FORMULA: C10H13N5O5 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00322 EHMN_ABBREVIATION: C00387
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110045#_3dafb3b4_288b_4093_bcde_7a0ecb64cc4e
is: P10696
is: SBO:0000252
has only substance units: false
boundary condition: true
is encoded by: hsa:251
name: ALPPL2
constant: false
initial amount: NaN
type: Species
initial concentration: NaN

metaR PYRt2m
kinetic law: MODEL1310110045#
reversible: true
is described by: ECO:0000000
type: Reaction
notes: GENE_ASSOCIATION: (6566.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:6987111 NOTES:IF changed name from "tm" to "t2m" - NCD
modifier: MODEL1310110045#
fast: false
product: MODEL1310110045#
is: SBO:0000185
name: pyruvate mitochondrial transport via proton symport
reactant: MODEL1310110045#

metaM taur c
is: C00245
notes: FORMULA: C2H7NO3S CHARGE: 0
initial concentration: 1.0
initial amount: NaN
type: Species
has only substance units: false
constant: false
boundary condition: false
is: CHEBI:3544
is: HMDB00251
name: Taurine
is: SBO:0000247

metaR HISTAtu
modifier: MODEL1310110045#
kinetic law: MODEL1310110045#
reversible: true
is described by: ECO:0000269
fast: false
reactant: MODEL1310110045#
notes: GENE_ASSOCIATION: (6581.1) or (6582.2) or (6582.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12883891 NOTES:SAB electrogenic, Na indepdendent & rev NJ
product: MODEL1310110045#
name: Histamine uniport
is: SBO:0000185
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110045#_e52171c8_a1a0_4f14_a2a1_e0d4d9f94d1b
name: _BE966236_1_m
is encoded by: hsa:BE966236
initial concentration: NaN
boundary condition: true
has only substance units: false
is: SBO:0000252
constant: false
type: Species
initial amount: NaN

metaR EX ppa LPAREN e RPAREN
kinetic law: MODEL1310110045#
reactant: MODEL1310110045#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Propionate exchange
type: Reaction

metaM 3dodtricoa m
type: Species
is: C05280
name: 3,6,9-dodecatrienoylcoa
constant: false
is: SBO:0000247
initial amount: NaN
has only substance units: false
is: HMDB03952
initial concentration: 1.0
notes: FORMULA: C33H48N7O17P3S CHARGE: -4
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110045#_d946fa62_2698_43e9_9dc2_032a25adbe0f
constant: false
initial amount: NaN
initial concentration: NaN
has only substance units: false
is encoded by: hsa:6817
is: SBO:0000252
type: Species
name: SULT1A1
boundary condition: true

metaR r0400
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/1.2.4.4
fast: false
kinetic law: MODEL1310110045#
product: MODEL1310110045#
reactant: MODEL1310110045#
is: SBO:0000176
name: N-acetylneuraminate,ferrocytochrome-b5:oxygen oxidoreductase (N-acetyl-hydroxylating) Aminosugars metabolism EC:1.14.18.2
type: Reaction
reversible: true
modifier: MODEL1310110045#
notes: GENE_ASSOCIATION: (594.1) or (641649.1) SUBSYSTEM: Unassigned EC Number: 1.14.18.2 Confidence Level: 0 AUTHORS: PMID:11522391,PMID:12192086 NOTES:

metaR r2323
is: SBO:0000185
fast: false
is described by: ECO:0000000
kinetic law: MODEL1310110045#
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
reversible: true
reactant: MODEL1310110045#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
product: MODEL1310110045#
type: Reaction

metaR r0276
type: Reaction
kinetic law: MODEL1310110045#
notes: GENE_ASSOCIATION: (10327.1) or (231.1) SUBSYSTEM: Purine catabolism EC Number: 1.7.1.7 Confidence Level: 0 AUTHORS: PMID:12009299,PMID:12669231 NOTES:
fast: false
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.1.1.2
is version of: http://identifiers.org/ec-code/1.1.1.21
reversible: true
name: NADH:guanosine-5-phosphate oxidoreductase(deaminating) Purine metabolism EC:1.7.1.7
reactant: MODEL1310110045#
modifier: MODEL1310110045#
product: MODEL1310110045#
is described by: ECO:0000000

metaM xol7ah2al c
is: SBO:0000247
boundary condition: false
has only substance units: false
initial concentration: 1.0
type: Species
is: HMDB06894
name: 3alpha,7alpha-dihydroxy-5beta-cholestan-26-al
is: CHEBI:27428
notes: FORMULA: C27H46O3 CHARGE: 0 INCHI: InChI=1S/C27H46O3/c1-17(16-28)6-5-7-18(2)21-8-9-22-25-23(11-13-27(21,22)4)26(3)12-10-20(29)14-19(26)15-24(25)30/h16-25,29-30H,5-15H2,1-4H3/t17?,18-,19+,20-,21-,22+,23+,24-,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01454 EHMN_ABBREVIATION: C05445
constant: false
initial amount: NaN

metaR 3HCO3 NAt
name: 3HCO3_NAt
reactant: MODEL1310110045#
kinetic law: MODEL1310110045#
is described by: ECO:0000134
product: MODEL1310110045#
fast: false
type: Reaction
is: SBO:0000185
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID: 11875267, PMID: 18077606. NOTES:Na/hco3 co-transporter, expressed at the basolateral side, meant for uptake of hco3, expressed highly in the intestine (NBC1).

http://identifiers.org/biomodels.db/MODEL1310110045#_518d68ea_2a9b_4b8e_9ffe_cb6836eac498
is encoded by: hsa:9197
boundary condition: true
constant: false
type: Species
name: SLC33A1
is: SBO:0000252
initial amount: NaN
initial concentration: NaN
has only substance units: false
is: O00400

metaR FRDPtr
product: MODEL1310110045#
fast: false
is: SBO:0000185
name: lipid, flip-flop intracellular transport
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: PMID:12121718,PMID:12840657,PMID:14713247 NOTES:cholesterol precursor, transport by "diffusion" -> actually beleived to be flip-flop mechanism (PMID: 12840657). See also Krisans (PMID: 14713247, PMID: 12121718) for synthesis of cholesterol pathway (why FRDP needs to be transported between ER and peroxisome) NJ
type: Reaction
is described by: ECO:0000000
reactant: MODEL1310110045#
kinetic law: MODEL1310110045#
reversible: true

metaM pchol hs c
initial concentration: 1.0
has only substance units: false
name: Phosphatidylcholine
constant: false
notes: FORMULA: C8H18NO4PFULLRCO2FULLR2CO2 CHARGE: 0
is: CHEBI:16110
type: Species
boundary condition: false
is: SBO:0000247
initial amount: NaN

metaR DGNSKm
notes: GENE_ASSOCIATION: (1716.5) or (1716.1) or (1716.4) or (1716.2) or (1716.3) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.1.113 Confidence Level: 4 AUTHORS: PMID:12535661,PMID:8692979 NOTES:
modifier: MODEL1310110045#
is version of: http://identifiers.org/ec-code/2.7.1.113
fast: false
kinetic law: MODEL1310110045#
product: MODEL1310110045#
is: SBO:0000176
type: Reaction
reversible: false
name: deoxyguanosine kinase
reactant: MODEL1310110045#
is described by: ECO:0000269

http://identifiers.org/biomodels.db/MODEL1310110045#_80f1f01c_5fb1_45f3_80d4_f6985601919a
type: Species
initial amount: NaN
is: SBO:0000252
boundary condition: true
initial concentration: NaN
name: _BF195998_1_x
is encoded by: hsa:BF195998
has only substance units: false
constant: false

http://identifiers.org/biomodels.db/MODEL1310110045#_e1664f15_775e_4af4_87f1_58b6548788b8
constant: false
initial concentration: NaN
type: Species
boundary condition: true
is: SBO:0000252
has only substance units: false
is: O75106
is encoded by: hsa:314
initial amount: NaN
name: AOC2

metaR EX udpgal LPAREN e RPAREN
kinetic law: MODEL1310110045#
reactant: MODEL1310110045#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: UDP-D-galactose(2-) exchange
type: Reaction

metaR r2322
is described by: ECO:0000000
reactant: MODEL1310110045#
reversible: true
is: SBO:0000185
fast: false
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
kinetic law: MODEL1310110045#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
product: MODEL1310110045#

metaM inost e
type: Species
has only substance units: false
is: HMDB00211
name: myo-inositol
is: SBO:0000247
constant: false
notes: FORMULA: C6H12O6 CHARGE: 0 INCHI: InChI=1S/C6H12O6/c7-1-2(8)4(10)6(12)5(11)3(1)9/h1-12H/t1-,2-,3-,4+,5-,6- HEPATONET_1.0_ABBREVIATION: HC00135 EHMN_ABBREVIATION: C00137
initial amount: NaN
initial concentration: 1.0
boundary condition: false
is: CHEBI:17268

http://identifiers.org/biomodels.db/MODEL1310110045#_f05a5d27_4ffa_45ea_8819_065f386cdfb5
boundary condition: true
constant: false
is encoded by: hsa:8534
is: O43916
initial concentration: NaN
is: SBO:0000252
has only substance units: false
type: Species
name: CHST1
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110045#_0c678c1f_8d82_477f_8696_c13052cf98b3
initial amount: NaN
initial concentration: NaN
is: SBO:0000252
has only substance units: false
is encoded by: hsa:2348
name: FOLR1
constant: false
is: P15328
boundary condition: true
type: Species

http://identifiers.org/biomodels.db/MODEL1310110045#_0510cea6_e710_4d03_96f6_0b59d512689c
is encoded by: hsa:8526
type: Species
boundary condition: true
initial amount: NaN
has only substance units: false
name: DGKE
is: A1L4Q0
is: SBO:0000252
constant: false
initial concentration: NaN

metaM ptth m
notes: FORMULA: C11H22N2O4S CHARGE: 0 INCHI: InChI=1S/C11H22N2O4S/c1-11(2,7-14)9(16)10(17)13-4-3-8(15)12-5-6-18/h9,14,16,18H,3-7H2,1-2H3,(H,12,15)(H,13,17)/t9-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00554 EHMN_ABBREVIATION: C00831
name: pantetheine
boundary condition: false
initial concentration: 1.0
initial amount: NaN
is: HMDB03426
constant: false
is: CHEBI:16753
has only substance units: false
is: SBO:0000247
type: Species

http://identifiers.org/biomodels.db/MODEL1310110045#_9e1367ba_ffa1_486d_829b_804de49e435c
has only substance units: false
is: SBO:0000252
is: Q96CA6
is encoded by: hsa:30
constant: false
initial amount: NaN
boundary condition: true
initial concentration: NaN
type: Species
name: ACAA1

http://identifiers.org/biomodels.db/MODEL1310110045#_ed63f6b1_4d09_44ef_b329_5b9a443f5998
is: P34896
name: SHMT1
is encoded by: hsa:6470
constant: false
is: SBO:0000252
has only substance units: false
type: Species
boundary condition: true
initial amount: NaN
initial concentration: NaN

metaR r2321
type: Reaction
fast: false
is: SBO:0000185
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
kinetic law: MODEL1310110045#
is described by: ECO:0000000
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
product: MODEL1310110045#
reactant: MODEL1310110045#

metaM Ser Gly Ala X Gly l
initial amount: NaN
constant: false
name: protein-linked serine residue (glycosaminoglycan attachment site)
notes: FORMULA: XH CHARGE: 0
is: HMDB02183
is: SBO:0000247
type: Species
has only substance units: false
boundary condition: false
initial concentration: 1.0
is: CHEBI:36005

metaM ksi pre15 g
type: Species
has only substance units: false
initial concentration: 1.0
constant: false
is: C00130
name: keratan sulfate I biosynthesis, precursor 15
boundary condition: false
is: CHEBI:58053
initial amount: NaN
notes: FORMULA: C149H240N10O119S4X CHARGE: -5
is: HMDB00175
is: SBO:0000247

metaM 56dura c
notes: FORMULA: C4H6N2O2 CHARGE: 0 INCHI: InChI=1S/C4H6N2O2/c7-3-1-2-5-4(8)6-3/h1-2H2,(H2,5,6,7,8) HEPATONET_1.0_ABBREVIATION: HC00348 EHMN_ABBREVIATION: C00429
constant: false
is: CHEBI:15901
is: SBO:0000247
initial concentration: 1.0
has only substance units: false
is: HMDB00076
name: 5,6-dihydrouracil
boundary condition: false
type: Species
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110045#_71107d9f_337c_441f_8601_e31504aa7059
constant: false
is: P56181
is: SBO:0000252
initial concentration: NaN
has only substance units: false
type: Species
boundary condition: true
initial amount: NaN
name: NDUFV3
is encoded by: hsa:4731

metaM arachdcrn m
is: CHEBI:57387
is: HMDB01322
is: SBO:0000247
initial amount: NaN
initial concentration: 1.0
constant: false
has only substance units: false
name: C20:4 carnitine
notes: FORMULA: C27H45NO4 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC12236
boundary condition: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110045#_42fcc786_67dd_4346_aa5d_0f642e2f1c49
is: O14732
is: SBO:0000252
constant: false
boundary condition: true
initial concentration: NaN
type: Species
has only substance units: false
initial amount: NaN
name: IMPA2
is encoded by: hsa:3613

metaM inost c
is: CHEBI:17268
type: Species
name: myo-inositol
is: HMDB00211
is: SBO:0000247
constant: false
notes: FORMULA: C6H12O6 CHARGE: 0 INCHI: InChI=1S/C6H12O6/c7-1-2(8)4(10)6(12)5(11)3(1)9/h1-12H/t1-,2-,3-,4+,5-,6- HEPATONET_1.0_ABBREVIATION: HC00135 EHMN_ABBREVIATION: C00137
initial concentration: 1.0
boundary condition: false
initial amount: NaN
has only substance units: false