metaM phyt x
boundary condition: false
is: HMDB00801
type: Species
has only substance units: false
initial amount: NaN
is: SBO:0000247
name: phytanate
is: CHEBI:37257
initial concentration: 1.0
constant: false
notes: FORMULA: C20H39O2 CHARGE: -1 INCHI: InChI=1S/C20H40O2/c1-16(2)9-6-10-17(3)11-7-12-18(4)13-8-14-19(5)15-20(21)22/h16-19H,6-15H2,1-5H3,(H,21,22)/p-1 EHMN_ABBREVIATION: C01607

http://identifiers.org/biomodels.db/MODEL1310110042#_99881d1c_b7db_42a9_b798_ad65f5e34326
type: Species
is: SBO:0000252
boundary condition: true
is encoded by: hsa:29925
name: GMPPB
initial concentration: NaN
has only substance units: false
initial amount: NaN
constant: false

metaM core2 g
constant: false
initial concentration: 1.0
notes: FORMULA: C22H37N2O15X CHARGE: 0
initial amount: NaN
name: Core 2
type: Species
is: SBO:0000247
is: CHEBI:15876
boundary condition: false
has only substance units: false

metaM 3mop m
is: HMDB00491
initial amount: NaN
initial concentration: 1.0
is: SBO:0000247
name: 3-methyl-2-oxopentanoate
has only substance units: false
is: CHEBI:28654
type: Species
constant: false
boundary condition: false
notes: FORMULA: C6H9O3 CHARGE: -1 INCHI: InChI=1S/C6H10O3/c1-3-4(2)5(7)6(8)9/h4H,3H2,1-2H3,(H,8,9)/p-1 HEPATONET_1.0_ABBREVIATION: HC01123 EHMN_ABBREVIATION: C00671

metaR r0634
product: MODEL1310110042#
name: Octanoyl-CoA:acetyl-CoA C-acyltransferase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:2.3.1.16
type: Reaction
is: SBO:0000176
fast: false
kinetic law: MODEL1310110042#
reversible: true
reactant: MODEL1310110042#
notes: GENE_ASSOCIATION: (AI926493.1) or (5167.1) or (5169.1) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.16 Confidence Level: 0 AUTHORS: PMID:1121274,PMID:1679347,PMID:3194209,PMID:6378901,PMID:8241273 NOTES:
modifier: MODEL1310110042#
is version of: http://identifiers.org/ec-code/3.1.4.1
is described by: ECO:0000000

metaR RE0958E
is version of: http://identifiers.org/ec-code/3.2.1.17
modifier: MODEL1310110042#
is version of: http://identifiers.org/ec-code/3.2.1.1
name: RE0958
fast: false
is: SBO:0000176
kinetic law: MODEL1310110042#
type: Reaction
is described by: ECO:0000000
reactant: MODEL1310110042#
product: MODEL1310110042#
reversible: true
notes: GENE_ASSOCIATION: (276.1) or (277.1) or (278.1) or (279.1) or (276.1) or (277.1) or (278.1) or (279.1) or (280.1) or (84569.1) SUBSYSTEM: Starch and sucrose metabolism EC Number: 3.2.1.1 Confidence Level: 0 AUTHORS: PMID:8528071,PMID:890964 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110042#_cf5042e9_c77a_4cf4_a275_51c100e57d82
initial concentration: NaN
has only substance units: false
name: PTDSS1
boundary condition: true
is: P48651
constant: false
type: Species
is encoded by: hsa:9791
is: SBO:0000252
initial amount: NaN

metaR PItx
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 1 AUTHORS: NOTES:diffusion NJ
is: SBO:0000185
kinetic law: MODEL1310110042#
reactant: MODEL1310110042#
name: Phosphate transporter, peroxisome
fast: false
reversible: true
is described by: ECO:0000000
product: MODEL1310110042#

metaM ksii core2 pre4 g
initial amount: NaN
notes: FORMULA: C53H86N4O38X CHARGE: -1
is: C00130
name: keratan sulfate II biosynthesis, precursor 4
constant: false
initial concentration: 1.0
is: SBO:0000247
is: CHEBI:58053
has only substance units: false
boundary condition: false
is: HMDB00175
type: Species

http://identifiers.org/biomodels.db/MODEL1310110042#_2608b2be_1911_4192_a5bf_2d3e26ed3ab6
initial concentration: NaN
has only substance units: false
type: Species
is encoded by: hsa:5152
initial amount: NaN
is: SBO:0000252
constant: false
name: PDE9A
boundary condition: true

metaM c4dc x
type: Species
name: succinyl carnitine
is: C02862
initial concentration: 1.0
is: http://identifiers.org/pubchem.compound/213144
constant: false
notes: FORMULA: C11H18NO6 CHARGE: -1
initial amount: NaN
is: SBO:0000247
is: HMDB02013
boundary condition: false
has only substance units: false

metaM sgalside hs c
notes: FORMULA: C24H45NO10SFULLRCO CHARGE: -1
constant: false
has only substance units: false
boundary condition: false
type: Species
is: HMDB03406
initial amount: NaN
initial concentration: 1.0
is: SBO:0000247
name: sulfatide galactocerebroside
is: CHEBI:16523

metaR r1605
is: SBO:0000185
reactant: MODEL1310110042#
kinetic law: MODEL1310110042#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
product: MODEL1310110042#
type: Reaction
is described by: ECO:0000000
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reversible: true

metaR ASAH1
product: MODEL1310110042#
kinetic law: MODEL1310110042#
type: Reaction
fast: false
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/3.5.1.23
reactant: MODEL1310110042#
is: SBO:0000176
notes: GENE_ASSOCIATION: (427.1) or (427.2) SUBSYSTEM: Sphingolipid metabolism EC Number: 3.5.1.23 Confidence Level: 4 AUTHORS: PMID:8955159 NOTES:NJ
name: N-acylsphingosine amidohydrolase
modifier: MODEL1310110042#
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110042#_622c5189_7841_4c16_ab6d_37df4199161f
is encoded by: hsa:27165
name: GLS2
constant: false
boundary condition: true
has only substance units: false
type: Species
initial concentration: NaN
initial amount: NaN
is: SBO:0000252
is: Q9UI32

metaR r0633
type: Reaction
is: SBO:0000176
product: MODEL1310110042#
reversible: true
modifier: MODEL1310110042#
name: trans-Oct-2-enoyl-CoA reductase Fatty acid elongation in mitochondria EC:1.3.1.38
fast: false
kinetic law: MODEL1310110042#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (80347.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.1.38 Confidence Level: 0 AUTHORS: PMID:12654921 NOTES:
is version of: http://identifiers.org/ec-code/2.7.7.3
reactant: MODEL1310110042#

metaR P4502C19
reactant: MODEL1310110042#
modifier: MODEL1310110042#
name: cytochrome P450 2C19
is described by: ECO:0000000
type: Reaction
product: MODEL1310110042#
reversible: false
notes: GENE_ASSOCIATION: (1557.1) SUBSYSTEM: Cytochrome metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:15579107,PMID:3442670 NOTES:omeprazole 5 methyl hydroxylation assumed to take place on outer membrane - since a xenobiotic NJ
kinetic law: MODEL1310110042#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.14.13.48
fast: false

metaR C161CPT12
name: carnitine O-palmitoyltransferase
product: MODEL1310110042#
is: SBO:0000176
fast: false
is described by: ECO:0000269
reversible: false
kinetic law: MODEL1310110042#
notes: GENE_ASSOCIATION: (126129.1) or (1375.3) or (1375.1) or (1375.2) or (1374.1) or (1375.4) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.21 Confidence Level: 4 AUTHORS: NOTES:NJ
modifier: MODEL1310110042#
is version of: http://identifiers.org/ec-code/2.3.1.21
reactant: MODEL1310110042#
type: Reaction

metaM dhor S c
is: HMDB03349
constant: false
is: SBO:0000247
initial concentration: 1.0
initial amount: NaN
has only substance units: false
type: Species
boundary condition: false
name: (S)-dihydroorotate
is: CHEBI:30864
notes: FORMULA: C5H5N2O4 CHARGE: -1 INCHI: InChI=1S/C5H6N2O4/c8-3-1-2(4(9)10)6-5(11)7-3/h2H,1H2,(H,9,10)(H2,6,7,8,11)/p-1/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00285

metaM m6mpdol L r
boundary condition: false
has only substance units: false
initial concentration: 1.0
is: SBO:0000247
constant: false
is: CHEBI:37635
initial amount: NaN
type: Species
notes: FORMULA: C1660H2728N20O520P20 CHARGE: -20
name: (alpha-D-Mannosyl)6-beta-D-mannosyl-diacetylchitobiosyldiphosphodolichol, human liver homolog

metaR INSTt4 2
reactant: MODEL1310110042#
is described by: ECO:0000006
reversible: true
type: Reaction
modifier: MODEL1310110042#
kinetic law: MODEL1310110042#
name: inositol transport via sodium symport
notes: GENE_ASSOCIATION: (115584.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12039040,PMID:12133831 NOTES:NCD
is: SBO:0000185
product: MODEL1310110042#
fast: false

http://identifiers.org/biomodels.db/MODEL1310110042#_de5b8028_b170_4816_986f_49a0fb385c9b
type: Species
boundary condition: true
has only substance units: false
name: PMM1
initial amount: NaN
is: SBO:0000252
is encoded by: hsa:5372
is: A8K003
initial concentration: NaN
constant: false

metaR DATPtn
product: MODEL1310110042#
type: Reaction
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: NOTES:IT
reactant: MODEL1310110042#
name: dATP diffusion in nucleus
fast: false
kinetic law: MODEL1310110042#
is: SBO:0000185
reversible: true

metaR r1606
kinetic law: MODEL1310110042#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
fast: false
reversible: true
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
product: MODEL1310110042#
type: Reaction
is described by: ECO:0000000
is: SBO:0000185
reactant: MODEL1310110042#

metaM ksi deg19 l
is: SBO:0000247
type: Species
is: CHEBI:16953
is: HMDB00812
boundary condition: false
initial amount: NaN
initial concentration: 1.0
has only substance units: false
notes: FORMULA: C146H236N10O124S6 CHARGE: -6
name: keratan sulfate I, degradation product 19
constant: false

metaR HPDCACRNCPT2
kinetic law: MODEL1310110042#
modifier: MODEL1310110042#
name: heptadecanoate transport into the mitochondria
reactant: MODEL1310110042#
reversible: false
product: MODEL1310110042#
is described by: ECO:0000000
type: Reaction
notes: GENE_ASSOCIATION: (1376.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: PMID:11274214,PMID:1528846,PMID:1988962 NOTES:NJ
fast: false
is version of: http://identifiers.org/ec-code/2.3.1.21
is: SBO:0000176

metaM uppg3 c
constant: false
has only substance units: false
boundary condition: false
is: C01051
is: SBO:0000247
name: Uroporphyrinogen III
type: Species
initial concentration: 1.0
is: HMDB01086
initial amount: NaN
is: CHEBI:57308
notes: FORMULA: C40H36N4O16 CHARGE: -8 HEPATONET_1.0_ABBREVIATION: HC00643 EHMN_ABBREVIATION: C01051

metaR r0636
type: Reaction
name: Octanoyl-CoA:L-carnitine O-octanoyltransferase EC:2.3.1.137
is: SBO:0000176
reactant: MODEL1310110042#
modifier: MODEL1310110042#
product: MODEL1310110042#
kinetic law: MODEL1310110042#
reversible: false
is described by: ECO:0000000
fast: false
notes: GENE_ASSOCIATION: (6576.1) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.137 Confidence Level: 0 AUTHORS: PMID:1735445,PMID:1988962,PMID:2355017,PMID:6361812,PMID:7892212 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110042#_72b69c43_91b5_4ec0_808e_672f8ce0fa4c
is encoded by: hsa:AI222095
name: _AI222095_1_e
initial amount: NaN
constant: false
type: Species
initial concentration: NaN
is: SBO:0000252
boundary condition: true
has only substance units: false

metaR r1607
reversible: true
kinetic law: MODEL1310110042#
type: Reaction
is described by: ECO:0000000
product: MODEL1310110042#
fast: false
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reactant: MODEL1310110042#

http://identifiers.org/biomodels.db/MODEL1310110042#_70b58180_586c_4267_b9bd_e26a8ba67122
has only substance units: false
type: Species
is encoded by: hsa:AW277253
boundary condition: true
constant: false
name: _AW277253_1_c
initial concentration: NaN
initial amount: NaN
is: SBO:0000252

metaR FMNAT
fast: false
is version of: http://identifiers.org/ec-code/2.7.7.2
modifier: MODEL1310110042#
reversible: false
kinetic law: MODEL1310110042#
is: SBO:0000176
name: FMN adenylyltransferase
is described by: ECO:0000134
type: Reaction
notes: GENE_ASSOCIATION: (80308.1) or (80308.2) SUBSYSTEM: Vitamin B2 metabolism EC Number: 2.7.7.2 Confidence Level: 2 AUTHORS: PMID:16643857,PMID:17049878 NOTES:Human Y/N: Y
reactant: MODEL1310110042#
product: MODEL1310110042#

metaM so4 l
notes: FORMULA: O4S CHARGE: -2 INCHI: InChI=1S/H2O4S/c1-5(2,3)4/h(H2,1,2,3,4)/p-2 HEPATONET_1.0_ABBREVIATION: HC00062 EHMN_ABBREVIATION: C00059
is: CHEBI:16189
boundary condition: false
is: HMDB01448
name: sulfate
type: Species
initial concentration: 1.0
is: SBO:0000247
constant: false
has only substance units: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110042#_d112b61b_bf33_412e_8063_51da3ec8e4a3
name: CHAT
is encoded by: hsa:1103
initial concentration: NaN
type: Species
constant: false
has only substance units: false
is: Q6LEN5
initial amount: NaN
is: SBO:0000252
boundary condition: true

metaR HPDCACRNCPT1
is: SBO:0000176
fast: false
is version of: http://identifiers.org/ec-code/2.3.1.21
modifier: MODEL1310110042#
notes: GENE_ASSOCIATION: (1375.2) or (1375.3) or (1374.1) or (126129.1) or (1375.1) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.21 Confidence Level: 4 AUTHORS: PMID:1988962 NOTES:NJ
is described by: ECO:0000000
type: Reaction
name: carnitine fatty-acyl transferase
kinetic law: MODEL1310110042#
reactant: MODEL1310110042#
reversible: false
product: MODEL1310110042#

metaR ALAtN1
reactant: MODEL1310110042#
fast: false
product: MODEL1310110042#
is described by: ECO:0000269
reversible: true
type: Reaction
is: SBO:0000185
kinetic law: MODEL1310110042#
modifier: MODEL1310110042#
name: Alanine transport (Na, H coupled)
notes: GENE_ASSOCIATION: (92745.1) or (10991.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10823827,PMID:12845534 NOTES:SAB based om PMID 10823827

http://identifiers.org/biomodels.db/MODEL1310110042#_2f0dc863_8837_448a_8301_f791dd9e523d
is encoded by: hsa:23169
type: Species
boundary condition: true
constant: false
initial concentration: NaN
initial amount: NaN
has only substance units: false
is: Q9NTN3
name: SLC35D1
is: SBO:0000252

metaM sebcoa c
initial amount: NaN
notes: FORMULA: C31H47N7O19P3S CHARGE: -5
initial concentration: 1.0
boundary condition: false
name: sebacoylcoa
type: Species
is: HMDB13325
is: SBO:0000247
has only substance units: false
constant: false

metaR FAOXC103C102m
kinetic law: MODEL1310110042#
product: MODEL1310110042#
reactant: MODEL1310110042#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C10:3-->C10:2)m
type: Reaction

metaR NCKt
reversible: true
type: Reaction
kinetic law: MODEL1310110042#
modifier: MODEL1310110042#
is described by: ECO:0000269
fast: false
name: Na+/Ca2+-K+ exchange
product: MODEL1310110042#
reactant: MODEL1310110042#
is: SBO:0000185
notes: GENE_ASSOCIATION: (123041.2) or (57419.1) or (9187.1) or (123041.3) or (25769.1) or (123041.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10484410,PMID:10662833,PMID:11294880,PMID:12379639,PMID:14770312,PMID:9478004 NOTES:NCD

metaM dolmanp L c
name: Dolichyl phosphate D-mannose, human liver homolog
is: SBO:0000247
initial amount: NaN
type: Species
has only substance units: false
constant: false
is: CHEBI:15809
notes: FORMULA: C1140H1868O90P10 CHARGE: -10 INCHI: InChI=1S/C31H55O9P/c1-22(2)11-7-12-23(3)13-8-14-24(4)15-9-16-25(5)17-10-18-26(6)19-20-38-41(36,37)40-31-30(35)29(34)28(33)27(21-32)39-31/h11,13,15,17,26-35H,7-10,12,14,16,18-21H2,1-6H3,(H,36,37)/b23-13+,24-15+,25-17-/t26?,27-,28-,29+,30+,31?/m1/s1
boundary condition: false
initial concentration: 1.0

metaR EX glygn5 LPAREN e RPAREN
kinetic law: MODEL1310110042#
reactant: MODEL1310110042#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for glycogen, structure 5 (glycogenin-2[1,4-Glc])
type: Reaction

metaR RE3556C
fast: false
reactant: MODEL1310110042#
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Eicosanoid metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:234423 NOTES:
is described by: ECO:0000000
type: Reaction
product: MODEL1310110042#
kinetic law: MODEL1310110042#
is: SBO:0000176
name: RE3556

metaR RE2649C
product: MODEL1310110042#
kinetic law: MODEL1310110042#
modifier: MODEL1310110042#
is version of: http://identifiers.org/ec-code/3.1.2.2
is: SBO:0000176
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/2.3.1.65
type: Reaction
fast: false
name: RE2649
reversible: true
reactant: MODEL1310110042#
notes: GENE_ASSOCIATION: (641372.1) or (641371.1) or (570.1) SUBSYSTEM: Bile acid synthesis EC Number: 3.1.2.2 Confidence Level: 0 AUTHORS: PMID:11013297 NOTES:

metaR EX tetpent6 LPAREN e RPAREN
kinetic law: MODEL1310110042#
reactant: MODEL1310110042#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: tetracosapentaenoic acid, n-6 exchange
type: Reaction

metaR r1608
reactant: MODEL1310110042#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
product: MODEL1310110042#
type: Reaction
is described by: ECO:0000000
is: SBO:0000185
fast: false
kinetic law: MODEL1310110042#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reversible: true

metaR PLA2 2
is: SBO:0000176
is described by: ECO:0000000
modifier: MODEL1310110042#
kinetic law: MODEL1310110042#
product: MODEL1310110042#
reversible: false
notes: GENE_ASSOCIATION: (8398.1) or (5320.1) or (8398.2) SUBSYSTEM: Glycerophospholipid metabolism EC Number: 3.1.1.4 Confidence Level: 4 AUTHORS: PMID:9272153,PMID:9417066 NOTES:phosphatidyl choline degradation NJ
is version of: http://identifiers.org/ec-code/3.1.1.4
reactant: MODEL1310110042#
fast: false
type: Reaction
name: phospholipase A2

http://identifiers.org/biomodels.db/MODEL1310110042#_56e06784_9d29_4d94_99a9_83b2e83a28f0
is: SBO:0000252
initial concentration: NaN
is encoded by: hsa:4842
has only substance units: false
constant: false
name: NOS1
type: Species
is: B4DG68
boundary condition: true
initial amount: NaN

metaM hxcoa m
is: HMDB06522
is: SBO:0000247
boundary condition: false
initial amount: NaN
constant: false
type: Species
name: Hexanoyl-CoA (n-C6:0CoA)
initial concentration: 1.0
notes: FORMULA: C27H42N7O17P3S CHARGE: -4
has only substance units: false

metaR r0630
fast: false
is version of: http://identifiers.org/ec-code/3.1.3.1
is described by: ECO:0000000
type: Reaction
is: SBO:0000176
reactant: MODEL1310110042#
notes: GENE_ASSOCIATION: (52.1) or (53.1) or (54.1) or (51205.1) or (55.1) or (AI191472.1) or (248.1) or (249.1) or (250.1) or (251.1) SUBSYSTEM: Bile acid synthesis EC Number: 2.3.1.65 Confidence Level: 0 AUTHORS: PMID:10884298,PMID:12239217,PMID:12543708,PMID:15026425,PMID:3741411,PMID:6884990 NOTES:
is version of: http://identifiers.org/ec-code/3.1.3.2
product: MODEL1310110042#
modifier: MODEL1310110042#
kinetic law: MODEL1310110042#
name: Choloyl-CoA:glycine N-choloyltransferase Bile acid biosynthesis / Taurine and hypotaurine metabolism EC:2.3.1.65
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110042#_9f18a069_0ff4_48cb_90ed_d836a16a49d7
is encoded by: hsa:1633
name: DCK
boundary condition: true
initial amount: NaN
is: P27707
is: SBO:0000252
type: Species
has only substance units: false
constant: false
initial concentration: NaN

metaM hmgcoa m
boundary condition: false
has only substance units: false
initial concentration: 1.0
type: Species
is: HMDB01375
constant: false
is: CHEBI:15467
notes: FORMULA: C27H39N7O20P3S CHARGE: -5 INCHI: InChI=1S/C27H44N7O20P3S/c1-26(2,21(40)24(41)30-5-4-15(35)29-6-7-58-17(38)9-27(3,42)8-16(36)37)11-51-57(48,49)54-56(46,47)50-10-14-20(53-55(43,44)45)19(39)25(52-14)34-13-33-18-22(28)31-12-32-23(18)34/h12-14,19-21,25,39-40,42H,4-11H2,1-3H3,(H,29,35)(H,30,41)(H,36,37)(H,46,47)(H,48,49)(H2,28,31,32)(H2,43,44,45)/t14-,19-,20-,21+,25-,27+/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00302 EHMN_ABBREVIATION: C00356
initial amount: NaN
is: SBO:0000247
name: Hydroxymethylglutaryl-CoA

metaM HC02187 e
is: SBO:0000247
notes: FORMULA: C15H12I3NO4 CHARGE: 0 INCHI: InChI=1S/C15H12I3NO4/c16-9-3-7(4-12(19)15(21)22)1-2-13(9)23-8-5-10(17)14(20)11(18)6-8/h1-3,5-6,12,20H,4,19H2,(H,21,22)
has only substance units: false
initial concentration: 1.0
initial amount: NaN
boundary condition: false
constant: false
name: reverse-triiodthyronine
type: Species
is: CHEBI:28774

metaM sgalside hs g
is: CHEBI:58343
initial concentration: 1.0
is: SBO:0000247
name: sulfatide galactocerebroside
constant: false
has only substance units: false
notes: FORMULA: C24H45NO10SFULLRCO CHARGE: -1
is: HMDB00061
boundary condition: false
initial amount: NaN
type: Species

metaR r0559
reactant: MODEL1310110042#
fast: false
notes: GENE_ASSOCIATION: (1719.1) or (HG2846-HT2983.1) SUBSYSTEM: Unassigned EC Number: 1.2.3.1 Confidence Level: 0 AUTHORS: PMID:11569919,PMID:16143537 NOTES:
is described by: ECO:0000000
type: Reaction
kinetic law: MODEL1310110042#
reversible: true
is: SBO:0000176
name: aldehyde oxidase Tyrosine metabolism EC:1.2.3.1
is version of: http://identifiers.org/ec-code/1.5.1.3
modifier: MODEL1310110042#
product: MODEL1310110042#

metaR r1609
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
type: Reaction
reactant: MODEL1310110042#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reversible: true
is: SBO:0000185
product: MODEL1310110042#
kinetic law: MODEL1310110042#
fast: false

metaM oh1 c
name: hydroxide ion
initial amount: NaN
constant: false
initial concentration: 1.0
boundary condition: false
is: SBO:0000247
is: C01328
is: HMDB01039
has only substance units: false
type: Species
notes: FORMULA: HO CHARGE: -1

metaR EX urate LPAREN e RPAREN
kinetic law: MODEL1310110042#
reactant: MODEL1310110042#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Urate exchange
type: Reaction

metaR r0345
is described by: ECO:0000000
fast: false
is version of: http://identifiers.org/ec-code/1.3.99.13
product: MODEL1310110042#
kinetic law: MODEL1310110042#
modifier: MODEL1310110042#
type: Reaction
reversible: true
notes: GENE_ASSOCIATION: (27034.1) or (28976.1) or (33.1) or (34.1) or (37.1) or (51.1) or (8310.1) or (AI285872.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.11 Confidence Level: 0 AUTHORS: PMID:11768308 NOTES:
name: ATP:AMP phosphotransferase Purine metabolism EC:2.7.4.11
reactant: MODEL1310110042#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.3.3.6
is version of: http://identifiers.org/ec-code/1.3.99.3

metaM 34dhmald c
is: http://identifiers.org/pubchem.compound/7903
name: 3,4-Dihydroxymandelaldehyde
is: C05577
has only substance units: false
boundary condition: false
initial concentration: 1.0
is: SBO:0000247
type: Species
constant: false
initial amount: NaN
is: HMDB06242
notes: FORMULA: C8H8O4 CHARGE: 0 INCHI: InChI=1/C8H8O4/c9-4-8(12)5-1-2-6(10)7(11)3-5/h1-4,8,10-12H HEPATONET_1.0_ABBREVIATION: HC01514 EHMN_ABBREVIATION: C05577

metaR RE1804C
name: RE1804
kinetic law: MODEL1310110042#
type: Reaction
reactant: MODEL1310110042#
is: SBO:0000176
is described by: ECO:0000000
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Bile acid synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:9660774 NOTES:
product: MODEL1310110042#
reversible: true

metaM 2octdectecoa m
initial concentration: 1.0
is: http://identifiers.org/pubchem.compound/5280355
name: 2,6,9,12-octadecatetraenoylcoa
constant: false
notes: FORMULA: C39H58N7O17P3S CHARGE: -4
boundary condition: false
initial amount: NaN
is: SBO:0000247
has only substance units: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110042#_5aa1fccf_da47_4098_a444_2505466b0e60
initial amount: NaN
constant: false
initial concentration: NaN
type: Species
has only substance units: false
is: SBO:0000252
is: P50336
name: PPOX
is encoded by: hsa:5498
boundary condition: true

metaM HC02207 e
name: prostaglandin-c2
is: CHEBI:27555
is: SBO:0000247
type: Species
notes: FORMULA: C20H29O4 CHARGE: -1 INCHI: InChI=1S/C20H30O4/c1-2-3-6-9-17(21)14-12-16-13-15-19(22)18(16)10-7-4-5-8-11-20(23)24/h4,7,12-14,17-18,21H,2-3,5-6,8-11,15H2,1H3,(H,23,24)/b7-4-,14-12+/t17-,18+/m0/s1 EHMN_ABBREVIATION: C05955
initial amount: NaN
constant: false
boundary condition: false
initial concentration: 1.0
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110042#_d6a00f88_a95e_485f_ac9b_e1db0dc66b36
is encoded by: hsa:6521
constant: false
initial amount: NaN
is: P02730
boundary condition: true
initial concentration: NaN
is: SBO:0000252
type: Species
name: SLC4A1
has only substance units: false

metaM 4izp c
is: SBO:0000247
initial concentration: 1.0
initial amount: NaN
constant: false
has only substance units: false
boundary condition: false
notes: FORMULA: C6H7N2O3 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC01157 EHMN_ABBREVIATION: C03680
is: HMDB01014
name: 4-Imidazolone-5-propanoate
is: CHEBI:57255
type: Species

metaM HC01403 x
is: CHEBI:28325
boundary condition: false
constant: false
type: Species
initial concentration: 1.0
name: (S)-Hydroxydecanoyl-CoA
notes: FORMULA: C31H50N7O18P3S CHARGE: -4 INCHI: InChI=1S/C31H54N7O18P3S/c1-4-5-6-7-8-9-19(39)14-22(41)60-13-12-33-21(40)10-11-34-29(44)26(43)31(2,3)16-53-59(50,51)56-58(48,49)52-15-20-25(55-57(45,46)47)24(42)30(54-20)38-18-37-23-27(32)35-17-36-28(23)38/h17-20,24-26,30,39,42-43H,4-16H2,1-3H3,(H,33,40)(H,34,44)(H,48,49)(H,50,51)(H2,32,35,36)(H2,45,46,47)/t19-,20+,24+,25+,26-,30+/m0/s1 EHMN_ABBREVIATION: C05264
has only substance units: false
is: SBO:0000247
initial amount: NaN

metaR FUMTSULtm
is: SBO:0000185
reversible: true
type: Reaction
reactant: MODEL1310110042#
product: MODEL1310110042#
fast: false
modifier: MODEL1310110042#
is described by: ECO:0000269
name: Fumarate:thiosulfate antiport, mitochondrial
kinetic law: MODEL1310110042#
notes: GENE_ASSOCIATION: (1468.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172,PMID:4441366 NOTES:MM

metaM ppcoa c
notes: FORMULA: C24H36N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00101 EHMN_ABBREVIATION: C00100
initial concentration: 1.0
constant: false
is: HMDB01275
name: Propanoyl-CoA
is: CHEBI:57392
boundary condition: false
has only substance units: false
type: Species
is: SBO:0000247
is: C00100
initial amount: NaN

metaR RE1709C
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Tetrahydrobiopterin metabolism EC Number: 4.2.1.96 Confidence Level: 0 AUTHORS: PMID:10727395,PMID:8921004 NOTES:
product: MODEL1310110042#
reversible: true
fast: false
kinetic law: MODEL1310110042#
name: RE1709
is: SBO:0000176
reactant: MODEL1310110042#
is described by: ECO:0000000

metaM so4 e
is: CHEBI:16189
is: HMDB01448
notes: FORMULA: O4S CHARGE: -2 INCHI: InChI=1S/H2O4S/c1-5(2,3)4/h(H2,1,2,3,4)/p-2 HEPATONET_1.0_ABBREVIATION: HC00062 EHMN_ABBREVIATION: C00059
is: SBO:0000247
type: Species
constant: false
name: sulfate
has only substance units: false
boundary condition: false
initial amount: NaN
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110042#_2522a46a_7d06_47ce_8b21_cdb46de78c50
is: G3XAJ0
initial amount: NaN
type: Species
is: SBO:0000252
constant: false
is encoded by: hsa:80724
initial concentration: NaN
boundary condition: true
has only substance units: false
name: ACAD10

metaR r0558
kinetic law: MODEL1310110042#
is described by: ECO:0000000
type: Reaction
name: Gentisate aldehyde:NAD+ oxidoreductase Tyrosine metabolism EC:1.2.1.29
is: SBO:0000176
modifier: MODEL1310110042#
reversible: true
notes: GENE_ASSOCIATION: (1719.1) or (HG2846-HT2983.1) SUBSYSTEM: Unassigned EC Number: 1.2.1.29 Confidence Level: 0 AUTHORS: PMID:11569919,PMID:16143537 NOTES:
reactant: MODEL1310110042#
fast: false
is version of: http://identifiers.org/ec-code/1.5.1.3
product: MODEL1310110042#

http://identifiers.org/biomodels.db/MODEL1310110042#_c81acab0_a56d_4de7_9164_d7f924dc2779
type: Species
has only substance units: false
is: O60488
name: ACSL4
is encoded by: hsa:2182
initial amount: NaN
constant: false
is: SBO:0000252
boundary condition: true
initial concentration: NaN

metaM itacon m
is: SBO:0000247
notes: FORMULA: C5H4O4 CHARGE: -2 INCHI: InChI=1S/C5H6O4/c1-3(5(8)9)2-4(6)7/h1-2H2,(H,6,7)(H,8,9)/p-2 EHMN_ABBREVIATION: C00490
boundary condition: false
is: HMDB02092
has only substance units: false
name: itaconate(2-)
initial concentration: 1.0
is: CHEBI:17240
type: Species
constant: false
initial amount: NaN

metaR sink octdececoa LPAREN c RPAREN
kinetic law: MODEL1310110042#
reactant: MODEL1310110042#
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: OCTDECECOASINK
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110042#_9c91e549_b677_4bd2_9056_22fce34d8c68
initial amount: NaN
boundary condition: true
type: Species
is encoded by: hsa:7108
is: O76062
is: SBO:0000252
constant: false
has only substance units: false
name: TM7SF2
initial concentration: NaN

metaM HC00319 m
is: CHEBI:30794
has only substance units: false
boundary condition: false
initial concentration: 1.0
name: Malonate
is: SBO:0000247
notes: FORMULA: C3H2O4 CHARGE: -2 INCHI: InChI=1S/C3H4O4/c4-2(5)1-3(6)7/h1H2,(H,4,5)(H,6,7)
initial amount: NaN
type: Species
constant: false

http://identifiers.org/biomodels.db/MODEL1310110042#_9d9cfa0d_850a_4bb9_88ab_ef9842512fc2
is encoded by: hsa:124
boundary condition: true
initial amount: NaN
initial concentration: NaN
has only substance units: false
name: ADH1A
type: Species
constant: false
is: SBO:0000252
is: P07327

metaM HC02187 c
is: CHEBI:28774
boundary condition: false
name: reverse-triiodthyronine
constant: false
initial amount: NaN
type: Species
has only substance units: false
notes: FORMULA: C15H12I3NO4 CHARGE: 0 INCHI: InChI=1S/C15H12I3NO4/c16-9-3-7(4-12(19)15(21)22)1-2-13(9)23-8-5-10(17)14(20)11(18)6-8/h1-3,5-6,12,20H,4,19H2,(H,21,22)
is: SBO:0000247
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110042#_fa008aac_470b_44ad_b5a2_fe9213a24bc2
is: SBO:0000252
has only substance units: false
initial amount: NaN
initial concentration: NaN
type: Species
constant: false
boundary condition: true
is encoded by: hsa:200010
name: SLC5A9
is: E9PAK4

MODEL1310110042
reaction: metaR r2109
species: metaM dectricoa x
reaction: metaR EX cspg a LPAREN e RPAREN
reaction: metaR FAOXC123C102m
reaction: metaR EX malthp LPAREN e RPAREN
species: metaM pail3p hs c
reaction: metaR METLEUex
species: metaM HC01403 x
reaction: metaR G5SDym
reaction: metaR GALASE8ly
species: metaM HC01401 x
species: metaM 2mp2coa m
species: metaM nrpphrsf e
species: metaM l2fn2m2masn g
reaction: metaR sink decdicoa LPAREN c RPAREN
species: metaM chol e
reaction: metaR GLUNm
species: metaM phaccoa c
reaction: metaR EX tymsf LPAREN e RPAREN
species: metaM mpdol L c
species: metaM lnlncgcoa m
reaction: metaR r2125
species: metaM xyl D e
species: metaM 2hexdtetcoa m
reaction: metaR r0647
reaction: metaR r0853
species: metaM glyc R m
reaction: metaR EX doco13ac
species: metaM cdpea c
reaction: metaR FAOXC150m
reaction: metaR EX rbt LPAREN e RPAREN
species: metaM hxcoa c
species: metaM eicostet e
species: metaM ps hs m
reaction: metaR r1619
reaction: metaR GLXtm
reaction: metaR PGK
reaction: metaR EX c4crn
reaction: metaR C8DCc
species: metaM ppa c
reaction: metaR OAGT3te
reaction: metaR RE3627M
reaction: metaR HDECAACBP
species: metaM 3octdectecoa m
reaction: metaR r1937
species: metaM udpacgal c
reaction: metaR r0944
reaction: metaR r0591
reaction: metaR r0365
reaction: metaR PROSTGI2tr
reaction: metaR C4tcx
reaction: metaR LEUKTRE4t
reaction: metaR BILIRUBtr
reaction: metaR LNLNCGCRNt
species: metaM thcholstoic x
reaction: metaR r0836
reaction: metaR r0758
species: metaM sl L c
species: metaM Rtotal e
reaction: metaR C10OHc
species: metaM retinal c
reaction: metaR HSAT2ly
reaction: metaR EX bilirub LPAREN e RPAREN
reaction: metaR EX HC01609 LPAREN e RPAREN
reaction: metaR r2354
species: metaM txa2 r
reaction: metaR r2128
reaction: metaR C4tmc
reaction: metaR RE3301C
reaction: metaR DAGt
reaction: metaR TCYNTt
reaction: metaR EX acnacngalgbside hs LPAREN e RPAREN
species: metaM taxol e
species: metaM lneldccoa c
reaction: metaR G6PDH2rer
species: metaM hs deg6 l
species: metaM lys L e
reaction: metaR r2024
reaction: metaR FUCASEe
reaction: metaR C51CPT1

http://identifiers.org/biomodels.db/MODEL1310110042#_b45d979e_e386_4999_a9df_1d215d62c91d
has only substance units: false
initial concentration: NaN
constant: false
is encoded by: hsa:4716
name: NDUFB10
is: SBO:0000252
initial amount: NaN
boundary condition: true
is: A8K761
type: Species

metaM gln L m
initial amount: NaN
initial concentration: 1.0
notes: FORMULA: C5H10N2O3 CHARGE: 0 INCHI: InChI=1S/C5H10N2O3/c6-3(5(9)10)1-2-4(7)8/h3H,1-2,6H2,(H2,7,8)(H,9,10)/t3-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00067
name: L-glutamine
boundary condition: false
is: HMDB00641
is: SBO:0000247
has only substance units: false
type: Species
constant: false
is: CHEBI:18050

metaR r2378
is described by: ECO:0000000
type: Reaction
reversible: true
product: MODEL1310110042#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:16919238,PMID:17173541,PMID:18406340,PMID:8132483 NOTES:
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
reactant: MODEL1310110042#
fast: false
kinetic law: MODEL1310110042#

metaM oh1 e
notes: FORMULA: HO CHARGE: -1
name: hydroxide ion
constant: false
is: SBO:0000247
is: C01328
is: HMDB01039
initial concentration: 1.0
boundary condition: false
has only substance units: false
type: Species
initial amount: NaN

metaM gam6p c
initial amount: NaN
initial concentration: 1.0
constant: false
boundary condition: false
is: SBO:0000247
notes: FORMULA: C6H13NO8P CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00298 EHMN_ABBREVIATION: C00352
has only substance units: false
name: D-Glucosamine 6-phosphate
is: CHEBI:12962
type: Species
is: HMDB01254

metaR VALtec
fast: false
is: SBO:0000185
notes: GENE_ASSOCIATION: (8501.1) or (124935.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12930836,PMID:14624363,PMID:15659399 NOTES:SAB
modifier: MODEL1310110042#
product: MODEL1310110042#
name: L-valine transport via diffusion (extracellular to cytosol)
type: Reaction
reversible: true
kinetic law: MODEL1310110042#
is described by: ECO:0000269
reactant: MODEL1310110042#

http://identifiers.org/biomodels.db/MODEL1310110042#_b6cbac70_d924_4e1b_b510_c3fdddac3d23
initial concentration: NaN
constant: false
is: SBO:0000252
name: HMGCS1
is encoded by: hsa:3157
type: Species
initial amount: NaN
has only substance units: false
boundary condition: true

metaR GLYt2r
is described by: ECO:0000304
is: SBO:0000185
modifier: MODEL1310110042#
notes: GENE_ASSOCIATION: (206358.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11390972,PMID:11959859 NOTES:NCD
reversible: true
product: MODEL1310110042#
fast: false
reactant: MODEL1310110042#
kinetic law: MODEL1310110042#
name: glycine reversible transport via proton symport
type: Reaction

metaR NADtn
product: MODEL1310110042#
is: SBO:0000185
type: Reaction
kinetic law: MODEL1310110042#
name: NAD transport, nuclear through pores
is described by: ECO:0000000
fast: false
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: NOTES:it
reactant: MODEL1310110042#

metaR r2379
is: SBO:0000185
type: Reaction
is described by: ECO:0000000
product: MODEL1310110042#
reactant: MODEL1310110042#
fast: false
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:16919238,PMID:17173541,PMID:18406340,PMID:8132483 NOTES:
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
kinetic law: MODEL1310110042#

metaR r0556
is version of: http://identifiers.org/ec-code/1.14.19.1
reactant: MODEL1310110042#
is described by: ECO:0000000
type: Reaction
modifier: MODEL1310110042#
notes: GENE_ASSOCIATION: (AF116616.1) or (PRO1933.1) or (6319.1) or (79966.1) SUBSYSTEM: Unassigned EC Number: 2.3.1.61 Confidence Level: 0 AUTHORS: PMID:8076640,PMID:9620315 NOTES:
reversible: true
name: succinyl-CoA:enzyme N6-(dihydrolipoyl)lysine S-succinyltransferase Citrate cycle (TCA cycle) EC:2.3.1.61
is: SBO:0000176
kinetic law: MODEL1310110042#
product: MODEL1310110042#
fast: false

metaR C142CPT1
kinetic law: MODEL1310110042#
product: MODEL1310110042#
reactant: MODEL1310110042#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: production of tetradecadienoylcarnitine
type: Reaction

metaR r0236
name: 5,6-Dihydrouracil:NAD+ oxidoreductase Pyrimidine metabolism EC:1.3.1.1
is: SBO:0000176
fast: false
reversible: true
is described by: ECO:0000000
kinetic law: MODEL1310110042#
notes: GENE_ASSOCIATION: (AI640625.1) or (51733.1) SUBSYSTEM: Pyrimidine catabolism EC Number: 1.3.1.1 Confidence Level: 0 AUTHORS: PMID:1260500 NOTES:
reactant: MODEL1310110042#
modifier: MODEL1310110042#
is version of: http://identifiers.org/ec-code/3.5.1.6
product: MODEL1310110042#
type: Reaction

metaR EX cbasp LPAREN e RPAREN
kinetic law: MODEL1310110042#
reactant: MODEL1310110042#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: Exchange of N-carbamoyl-L-aspartate
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110042#_a53a6d98_479b_4586_b3c3_a9bcbd35cfb8
is: SBO:0000252
is encoded by: hsa:2766
initial amount: NaN
constant: false
is: P36959
boundary condition: true
has only substance units: false
initial concentration: NaN
type: Species
name: GMPR

metaM HC01403 m
initial concentration: 1.0
has only substance units: false
is: SBO:0000247
initial amount: NaN
name: (S)-Hydroxydecanoyl-CoA
boundary condition: false
constant: false
is: CHEBI:28325
type: Species
notes: FORMULA: C31H50N7O18P3S CHARGE: -4 INCHI: InChI=1S/C31H54N7O18P3S/c1-4-5-6-7-8-9-19(39)14-22(41)60-13-12-33-21(40)10-11-34-29(44)26(43)31(2,3)16-53-59(50,51)56-58(48,49)52-15-20-25(55-57(45,46)47)24(42)30(54-20)38-18-37-23-27(32)35-17-36-28(23)38/h17-20,24-26,30,39,42-43H,4-16H2,1-3H3,(H,33,40)(H,34,44)(H,48,49)(H,50,51)(H2,32,35,36)(H2,45,46,47)/t19-,20+,24+,25+,26-,30+/m0/s1 EHMN_ABBREVIATION: C05264

http://identifiers.org/biomodels.db/MODEL1310110042#_cbf19d32_ad1e_41e1_910e_8894e872f16c
has only substance units: false
constant: false
boundary condition: true
is encoded by: hsa:29988
is: SBO:0000252
initial amount: NaN
name: SLC2A8
type: Species
initial concentration: NaN
is: Q9NY64

metaR FAOXC18480m
product: MODEL1310110042#
notes: GENE_ASSOCIATION: (34.1) or (35.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.74 Confidence Level: 4 AUTHORS: NOTES:_5 rounds of beta ox, 4 degrees loss of saturation -> only 1 fad oxidized to fadh2 peroxisomal (very long chain FA) c18:4,n-6 -> c8:0, 4 step FAO lumped for 2 rounds also includes EC 1.1.1.35, 1.1.1.211, 1.3.3.6, 4.2.1.17, 4.2.1.74 NJ
is: SBO:0000176
reactant: MODEL1310110042#
is version of: http://identifiers.org/ec-code/1.3.8.1
modifier: MODEL1310110042#
fast: false
type: Reaction
name: Beta oxidation of fatty acid
kinetic law: MODEL1310110042#
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/1.3.99.3
reversible: false

metaR S6T16g
is described by: ECO:0000000
reversible: false
modifier: MODEL1310110042#
product: MODEL1310110042#
reactant: MODEL1310110042#
type: Reaction
fast: false
kinetic law: MODEL1310110042#
name: galactose/N-acetylglucosamine 6-O-sulfotransferase, Golgi apparatus
is: SBO:0000176
notes: GENE_ASSOCIATION: (23563.2) or (9435.1) or (23563.1) or (10164.1) or (4166.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: Confidence Level: 4 AUTHORS: PMID:10330415,PMID:10491328,PMID:10913333,PMID:11278593,PMID:12403612,PMID:12855678,PMID:9722682 NOTES:NCD

http://identifiers.org/biomodels.db/MODEL1310110042#_7bb9cd71_0346_4854_ab03_e5acaef6181b
initial concentration: NaN
is: Q9NNW7
is: SBO:0000252
constant: false
boundary condition: true
is encoded by: hsa:10587
initial amount: NaN
type: Species
name: TXNRD2
has only substance units: false

metaM 4hphac c
is: SBO:0000247
notes: FORMULA: C8H7O3 CHARGE: -1 INCHI: InChI=1S/C8H8O3/c9-7-3-1-6(2-4-7)5-8(10)11/h1-4,9H,5H2,(H,10,11)/p-1 EHMN_ABBREVIATION: C00642
boundary condition: false
is: HMDB00020
initial amount: NaN
is: CHEBI:48999
type: Species
name: 4-hydroxyphenylacetate
constant: false
has only substance units: false
initial concentration: 1.0

metaM 2hexdtetcoa x
is: HMDB02288
name: 2,7,10,13-hexadecatetraenoylcoa
is: SBO:0000247
boundary condition: false
initial amount: NaN
has only substance units: false
constant: false
notes: FORMULA: C37H54N7O17P3S CHARGE: -4
type: Species
initial concentration: 1.0

metaR EX Rtotal LPAREN e RPAREN
kinetic law: MODEL1310110042#
reactant: MODEL1310110042#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: R total exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110042#_22023906_2e63_44b9_8e0d_dcdc81b3f55a
is encoded by: hsa:112
boundary condition: true
initial amount: NaN
is: O43306
type: Species
has only substance units: false
initial concentration: NaN
name: ADCY6
constant: false
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110042#_09c44b0b_04a6_4dc1_8b41_bdb427827e99
has only substance units: false
type: Species
initial amount: NaN
boundary condition: true
is: O95477
name: ABCA1
constant: false
is: SBO:0000252
is encoded by: hsa:19
initial concentration: NaN

metaR PPDOx
reversible: false
kinetic law: MODEL1310110042#
fast: false
reactant: MODEL1310110042#
is: SBO:0000176
modifier: MODEL1310110042#
type: Reaction
name: Propane-1,2-diol:NAD+ 1-oxidoreductase
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (8574.1) SUBSYSTEM: Pyruvate metabolism EC Number: 1.1.1.21 Confidence Level: 4 AUTHORS: PMID:12071861,PMID:9823300 NOTES:NCD
product: MODEL1310110042#

metaR r0787
type: Reaction
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/1.1.1.1
is: SBO:0000176
modifier: MODEL1310110042#
kinetic law: MODEL1310110042#
reactant: MODEL1310110042#
notes: GENE_ASSOCIATION: (124.1) or (125.1) or (128.1) or (130.1) or (131.1) or (AI291895.1) or (M68895.1) or (X63359.1) SUBSYSTEM: Sphingolipid metabolism EC Number: 3.1.3.4 Confidence Level: 0 AUTHORS: PMID:7575445 NOTES:
name: 3-sn-phosphatidate phosphohydrolase Sphingolipid metabolism EC:3.1.3.4
product: MODEL1310110042#
reversible: false
fast: false

metaR UDPG4E
type: Reaction
name: UDPglucose 4-epimerase
fast: false
kinetic law: MODEL1310110042#
is described by: ECO:0000134
product: MODEL1310110042#
notes: GENE_ASSOCIATION: (2582.1) or (2582.2) SUBSYSTEM: Galactose metabolism EC Number: 5.1.3.2 Confidence Level: 0 AUTHORS: PMID:11117433 NOTES:used yeast system to overexpress gene to determine mutant kinetic properties
is: SBO:0000176
reactant: MODEL1310110042#
reversible: true
modifier: MODEL1310110042#
is version of: http://identifiers.org/ec-code/5.1.3.2

metaR r2087
modifier: MODEL1310110042#
is: SBO:0000185
reactant: MODEL1310110042#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
product: MODEL1310110042#
reversible: true
kinetic law: MODEL1310110042#
fast: false
is described by: ECO:0000000
type: Reaction
name: Major Facilitator(MFS) TCDB:2.A.1.13.1

metaM HC02210 c
constant: false
initial amount: NaN
has only substance units: false
notes: FORMULA: C20H29O5 CHARGE: -1 INCHI: InChI=1S/C20H30O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h3-4,6-7,12-13,15-18,21-22H,2,5,8-11,14H2,1H3,(H,24,25)/b6-3-,7-4-,13-12+/t15-,16+,17+,18-/m0/s1
boundary condition: false
initial concentration: 1.0
is: SBO:0000247
name: prostaglandin-d3
type: Species
is: CHEBI:34939

http://identifiers.org/biomodels.db/MODEL1310110042#_137bd3d6_35ad_49c2_9d60_1a91eed97d55
has only substance units: false
initial concentration: NaN
is encoded by: hsa:AI480132
constant: false
boundary condition: true
initial amount: NaN
is: SBO:0000252
type: Species
name: _AI480132_1_c

metaM CE4722 e
type: Species
has only substance units: false
constant: false
is: http://identifiers.org/pubchem.compound/5041
initial amount: NaN
notes: FORMULA: C38H49N6O10 CHARGE: -1 INCHI: InChI=1/C38H50N6O10/c1-22(2)32(35(50)40-27(16-17-31(46)47)37(52)44-19-7-11-30(44)38(53)54)42-33(48)28(21-23-8-4-3-5-9-23)41-34(49)29-10-6-18-43(29)36(51)26(39)20-24-12-14-25(45)15-13-24/h3-5,8-9,12-15,22,26-30,32,45H,6-7,10-11,16-21,39H2,1-2H3,(H,40,50)(H,41,49)(H,42,48)(H,46,47)(H,53,54)/p-1/t26-,27+,28+,29-,30+,32-/m1/s1 EHMN_ABBREVIATION: CE4722
name: beta-casomorphin (1-6)
is: SBO:0000247
boundary condition: false
is: C01936
initial concentration: 1.0

metaM sql r
is: SBO:0000247
initial concentration: 1.0
type: Species
is: CHEBI:15440
has only substance units: false
constant: false
is: HMDB00256
notes: FORMULA: C30H50 CHARGE: 0 INCHI: InChI=1S/C30H50/c1-25(2)15-11-19-29(7)23-13-21-27(5)17-9-10-18-28(6)22-14-24-30(8)20-12-16-26(3)4/h15-18,23-24H,9-14,19-22H2,1-8H3/b27-17+,28-18+,29-23+,30-24+ HEPATONET_1.0_ABBREVIATION: HC00526 EHMN_ABBREVIATION: C00751
boundary condition: false
name: squalene
initial amount: NaN

metaM thbpt4acam n
notes: FORMULA: C9H15N5O4 CHARGE: 0 INCHI: InChI=1S/C9H15N5O4/c1-3(15)5(16)4-2-11-6-9(18,14-4)7(17)13-8(10)12-6/h3-5,14-16,18H,2H2,1H3,(H3,10,11,12,13,17) EHMN_ABBREVIATION: CE1951
is: CHEBI:15374
has only substance units: false
constant: false
type: Species
is: SBO:0000247
is: HMDB02281
initial concentration: 1.0
initial amount: NaN
name: 4a-hydroxytetrahydrobiopterin
boundary condition: false

metaM fpram c
is: SBO:0000247
initial amount: NaN
boundary condition: false
is: C04640
is: HMDB06211
notes: FORMULA: C8H15N3O8P CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC01329 EHMN_ABBREVIATION: C04640
initial concentration: 1.0
constant: false
has only substance units: false
is: CHEBI:58478
type: Species
name: 2-(Formamido)-N1-(5-phospho-D-ribosyl)acetamidine

metaM sgalside hs l
is: HMDB00904
notes: FORMULA: C24H45NO10SFULLRCO CHARGE: -1
initial amount: NaN
boundary condition: false
name: sulfatide galactocerebroside
constant: false
is: CHEBI:16349
is: SBO:0000247
initial concentration: 1.0
has only substance units: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110042#_f72cf40a_5036_4af7_b2e7_42f166ca250e
is: Q9Y619
initial amount: NaN
is: SBO:0000252
constant: false
initial concentration: NaN
boundary condition: true
is encoded by: hsa:10166
name: SLC25A15
has only substance units: false
type: Species

metaR DOPAtu
product: MODEL1310110042#
reversible: true
is: SBO:0000185
kinetic law: MODEL1310110042#
notes: GENE_ASSOCIATION: (6581.1) or (6582.2) or (6582.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12883891 NOTES:SAB electrogenic, Na indepdendent & rev NJ
fast: false
modifier: MODEL1310110042#
name: Dopamine uniport
is described by: ECO:0000269
reactant: MODEL1310110042#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110042#_bf7afb96_195b_4bb5_92b3_b836886420c6
boundary condition: true
is: O00400
initial amount: NaN
constant: false
is encoded by: hsa:9197
name: SLC33A1
initial concentration: NaN
type: Species
has only substance units: false
is: SBO:0000252

metaR ARACHDt2
is: SBO:0000185
kinetic law: MODEL1310110042#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11788354,PMID:12864740 NOTES:NJ
product: MODEL1310110042#
reactant: MODEL1310110042#
fast: false
name: fatty acid transport via diffusion
reversible: true
type: Reaction
is described by: ECO:0000000

metaM dtdp e
is: SBO:0000247
name: ({[(2R,3S,5R)-3-hydroxy-5-(5-methyl-2,4-dioxo-1,2,3,4-tetrahydropyrimidin-1-yl)oxolan-2-yl]methyl phosphonato}oxy)phosphonate
is: CHEBI:58369
is: HMDB01274
boundary condition: false
initial concentration: 1.0
has only substance units: false
type: Species
constant: false
initial amount: NaN
notes: FORMULA: C10H13N2O11P2 CHARGE: -3 INCHI: InChI=1S/C10H16N2O11P2/c1-5-3-12(10(15)11-9(5)14)8-2-6(13)7(22-8)4-21-25(19,20)23-24(16,17)18/h3,6-8,13H,2,4H2,1H3,(H,19,20)(H,11,14,15)(H2,16,17,18)/p-3/t6-,7+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00307 EHMN_ABBREVIATION: C00363

metaM eicostet c
type: Species
initial amount: NaN
has only substance units: false
notes: FORMULA: C20H31O2 CHARGE: -1
initial concentration: 1.0
is: HMDB02177
name: eicosatetranoic acid
constant: false
is: CHEBI:36033
is: SBO:0000247
boundary condition: false

metaM crtsl r
constant: false
is: CHEBI:17650
initial amount: NaN
initial concentration: 1.0
boundary condition: false
has only substance units: false
name: cortisol
notes: FORMULA: C21H30O5 CHARGE: 0 INCHI: InChI=1S/C21H30O5/c1-19-7-5-13(23)9-12(19)3-4-14-15-6-8-21(26,17(25)11-22)20(15,2)10-16(24)18(14)19/h9,14-16,18,22,24,26H,3-8,10-11H2,1-2H3/t14-,15-,16-,18+,19-,20-,21-/m0/s1 EHMN_ABBREVIATION: C00735
is: HMDB00063
type: Species
is: SBO:0000247

metaR TETDECE1CRNe
kinetic law: MODEL1310110042#
product: MODEL1310110042#
reactant: MODEL1310110042#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of tetradecenoyl carnitine into extra cellular space
type: Reaction

metaM CE4792 m
has only substance units: false
name: 3-oxo-cis-8-tetradecenoyl-CoA
is: CHEBI:57923
boundary condition: false
initial amount: NaN
is: SBO:0000247
type: Species
constant: false
initial concentration: 1.0
notes: FORMULA: C35H54N7O18P3S CHARGE: -4 INCHI: InChI=1/C35H58N7O18P3S/c1-4-5-6-7-8-9-10-11-12-13-23(43)18-26(45)64-17-16-37-25(44)14-15-38-33(48)30(47)35(2,3)20-57-63(54,55)60-62(52,53)56-19-24-29(59-61(49,50)51)28(46)34(58-24)42-22-41-27-31(36)39-21-40-32(27)42/h8-9,21-22,24,28-30,34,46-47H,4-7,10-20H2,1-3H3,(H,37,44)(H,38,48)(H,52,53)(H,54,55)(H2,36,39,40)(H2,49,50,51)/p-4/b9-8-/t24-,28+,29+,30u,34-/m0/s1 EHMN_ABBREVIATION: CE4792

metaR RE1527M
notes: GENE_ASSOCIATION: (3295.1) or (1962.1) or (3033.1) or (3028.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.1.1.35 Confidence Level: 0 AUTHORS: PMID:11451959 NOTES:
is described by: ECO:0000000
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.1.1.35
reactant: MODEL1310110042#
product: MODEL1310110042#
type: Reaction
kinetic law: MODEL1310110042#
modifier: MODEL1310110042#
fast: false
name: RE1527
reversible: true
is version of: http://identifiers.org/ec-code/4.2.1.107

http://identifiers.org/biomodels.db/MODEL1310110042#_409f84a1_bec5_4e4f_a232_fe7929a6afc0
boundary condition: true
initial concentration: NaN
has only substance units: false
is encoded by: hsa:AI631997
name: _AI631997_1_m
type: Species
initial amount: NaN
is: SBO:0000252
constant: false

metaM acgam1p c
initial amount: NaN
name: N-Acetyl-D-glucosamine 1-phosphate
is: CHEBI:7125
type: Species
constant: false
is: HMDB01367
is: SBO:0000247
has only substance units: false
boundary condition: false
notes: FORMULA: C8H14NO9P CHARGE: -2 INCHI: InChI=1S/C8H16NO9P/c1-3(11)9-5-7(13)6(12)4(2-10)17-8(5)18-19(14,15)16/h4-8,10,12-13H,2H2,1H3,(H,9,11)(H2,14,15,16)/t4-,5-,6-,7-,8?/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01256 EHMN_ABBREVIATION: C04256
initial concentration: 1.0

metaR GULNDer
type: Reaction
product: MODEL1310110042#
kinetic law: MODEL1310110042#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Pentose phosphate pathway EC Number: 1.1.1.19 Confidence Level: 2 AUTHORS: PMID:9296457 NOTES:NCD
reversible: true
is: SBO:0000176
name: gulonate dehydrogenase, endoplasmic reticulum
reactant: MODEL1310110042#
fast: false

metaR MANtly
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 2 AUTHORS: PMID:1751541,PMID:8993166 NOTES:NCD
reactant: MODEL1310110042#
is described by: ECO:0000000
product: MODEL1310110042#
name: mannose efflux from lysosome
is: SBO:0000185
kinetic law: MODEL1310110042#
type: Reaction
reversible: false
fast: false

metaR r2088
reversible: true
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
is: SBO:0000185
reactant: MODEL1310110042#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
product: MODEL1310110042#
type: Reaction
modifier: MODEL1310110042#
kinetic law: MODEL1310110042#
fast: false

metaR r0340
name: ATP:(R)-glycerate 3-phosphotransferase Glycine, serine and threonine metabolism EC:2.7.1.31
type: Reaction
modifier: MODEL1310110042#
is: SBO:0000176
notes: GENE_ASSOCIATION: (AA526438.1) or (H17063.1) or (51102.1) or (55825.1) SUBSYSTEM: Unassigned EC Number: 2.7.1.31 Confidence Level: 0 AUTHORS: PMID:16753811,PMID:216417,PMID:2537226,PMID:6252205 NOTES:
reactant: MODEL1310110042#
is version of: http://identifiers.org/ec-code/1.3.1.38
fast: false
reversible: false
is described by: ECO:0000000
kinetic law: MODEL1310110042#
product: MODEL1310110042#

metaR G5SADrm
type: Reaction
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Arginine and Proline Metabolism EC Number: Confidence Level: 4 AUTHORS: NOTES:spontaneous reaction NCD
kinetic law: MODEL1310110042#
is: SBO:0000176
name: L-glutamate 5-semialdehyde dehydratase, reversible, mitochondrial
is described by: ECO:0000000
product: MODEL1310110042#
reactant: MODEL1310110042#
fast: false

http://identifiers.org/biomodels.db/MODEL1310110042#_a6343beb_a21f_4b4c_821b_114878ecd4cf
initial concentration: NaN
name: SLC27A1
constant: false
is: Q6PCB7
has only substance units: false
boundary condition: true
is: SBO:0000252
type: Species
initial amount: NaN
is encoded by: hsa:376497

metaM vacc e
is: SBO:0000247
boundary condition: false
initial amount: NaN
constant: false
name: trans-vaccenate
has only substance units: false
notes: FORMULA: C18H33O2 CHARGE: -1 INCHI: InChI=1S/C18H34O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20/h7-8H,2-6,9-17H2,1H3,(H,19,20)/p-1/b8-7+
is: CHEBI:30828
type: Species
initial concentration: 1.0

metaM ksi pre2 g
type: Species
is: CHEBI:58053
initial amount: NaN
name: keratan sulfate I biosynthesis, precursor 2
is: SBO:0000247
is: C00130
constant: false
boundary condition: false
is: HMDB00175
has only substance units: false
notes: FORMULA: C87H142N6O62X CHARGE: -1
initial concentration: 1.0

metaM 4hphac e
initial concentration: 1.0
has only substance units: false
notes: FORMULA: C8H7O3 CHARGE: -1 INCHI: InChI=1S/C8H8O3/c9-7-3-1-6(2-4-7)5-8(10)11/h1-4,9H,5H2,(H,10,11)/p-1 EHMN_ABBREVIATION: C00642
boundary condition: false
is: HMDB00020
initial amount: NaN
is: CHEBI:48999
constant: false
type: Species
name: 4-hydroxyphenylacetate
is: SBO:0000247

metaR r0789
reversible: true
is: SBO:0000176
reactant: MODEL1310110042#
modifier: MODEL1310110042#
kinetic law: MODEL1310110042#
product: MODEL1310110042#
fast: false
is version of: http://identifiers.org/ec-code/1.14.13.15
type: Reaction
notes: GENE_ASSOCIATION: (1593.1) SUBSYSTEM: Sphingolipid metabolism EC Number: 2.1.1.103 Confidence Level: 0 AUTHORS: PMID:2403362 NOTES:
is described by: ECO:0000000
name: S-Adenosyl-L-methionine:phosphodimethylethanolamine N-methyltransferase Glycerophospholipid metabolism EC:2.1.1.103

metaR PItn
reactant: MODEL1310110042#
name: phosphate transport, nuclear
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: NOTES:IT
fast: false
is described by: ECO:0000000
type: Reaction
reversible: true
product: MODEL1310110042#
kinetic law: MODEL1310110042#
is: SBO:0000185

metaR RETH
type: Reaction
modifier: MODEL1310110042#
reversible: false
product: MODEL1310110042#
notes: GENE_ASSOCIATION: (8228.1) SUBSYSTEM: Vitamin A metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:1503811,PMID:15955102 NOTES:IT
is: SBO:0000176
fast: false
is described by: ECO:0000000
name: retinyl ester hydrolase
kinetic law: MODEL1310110042#
reactant: MODEL1310110042#
is version of: http://identifiers.org/ec-code/3.1.1.3

metaR SBTD D2
is: SBO:0000176
type: Reaction
is described by: ECO:0000000
reactant: MODEL1310110042#
name: D-sorbitol dehydrogenase (D-fructose producing)
notes: GENE_ASSOCIATION: (6652.1) SUBSYSTEM: Fructose and mannose metabolism EC Number: 1.1.1.14 Confidence Level: 0 AUTHORS: PMID:14965227 NOTES:NCD
modifier: MODEL1310110042#
is version of: http://identifiers.org/ec-code/1.1.1.14
fast: false
kinetic law: MODEL1310110042#
reversible: false
product: MODEL1310110042#

http://identifiers.org/biomodels.db/MODEL1310110042#_a6e16cb5_71c3_4a52_825a_eec0c2edbafd
is encoded by: hsa:5295
boundary condition: true
name: PIK3R1
initial concentration: NaN
type: Species
has only substance units: false
is: SBO:0000252
initial amount: NaN
constant: false
is: E7EX19

metaM 3mop c
constant: false
type: Species
is: SBO:0000247
boundary condition: false
initial concentration: 1.0
notes: FORMULA: C6H9O3 CHARGE: -1 INCHI: InChI=1S/C6H10O3/c1-3-4(2)5(7)6(8)9/h4H,3H2,1-2H3,(H,8,9)/p-1 HEPATONET_1.0_ABBREVIATION: HC01123 EHMN_ABBREVIATION: C00671
initial amount: NaN
has only substance units: false
is: HMDB00491
is: CHEBI:28654
name: 3-methyl-2-oxopentanoate

metaR r2089
reactant: MODEL1310110042#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
modifier: MODEL1310110042#
product: MODEL1310110042#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
reversible: true
fast: false
is described by: ECO:0000000
kinetic law: MODEL1310110042#
type: Reaction
is: SBO:0000185

metaM HC02210 e
constant: false
initial amount: NaN
has only substance units: false
is: SBO:0000247
notes: FORMULA: C20H29O5 CHARGE: -1 INCHI: InChI=1S/C20H30O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h3-4,6-7,12-13,15-18,21-22H,2,5,8-11,14H2,1H3,(H,24,25)/b6-3-,7-4-,13-12+/t15-,16+,17+,18-/m0/s1
boundary condition: false
initial concentration: 1.0
is: CHEBI:34939
name: prostaglandin-d3
type: Species

metaR HDD2COAtx
reversible: true
type: Reaction
is described by: ECO:0000000
name: hdd2coa intracellular transport
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 1 AUTHORS: NOTES:unknown mechanism NJ
product: MODEL1310110042#
reactant: MODEL1310110042#
kinetic law: MODEL1310110042#
is: SBO:0000185

metaR FUMSO4tm
fast: false
modifier: MODEL1310110042#
kinetic law: MODEL1310110042#
notes: GENE_ASSOCIATION: (1468.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172,PMID:4441366 NOTES:MM
name: Fumarate:sulfate antiport, mitochondrial
type: Reaction
reactant: MODEL1310110042#
is described by: ECO:0000269
reversible: true
is: SBO:0000185
product: MODEL1310110042#

metaR FATP1t
modifier: MODEL1310110042#
reversible: true
product: MODEL1310110042#
fast: false
reactant: MODEL1310110042#
is: SBO:0000185
is described by: ECO:0000269
type: Reaction
kinetic law: MODEL1310110042#
notes: GENE_ASSOCIATION: (376497.2) or (10999.1) or (376497.1) or (11000.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12856180,PMID:15522816,PMID:9878842 NOTES:electroneutral transport NJ
name: fatty acid electroneutral transport

metaR r1600
product: MODEL1310110042#
kinetic law: MODEL1310110042#
reactant: MODEL1310110042#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reversible: true
type: Reaction
is described by: ECO:0000000
fast: false
is: SBO:0000185

metaR PPDOy
product: MODEL1310110042#
is: SBO:0000176
notes: GENE_ASSOCIATION: (8574.1) or (231.1) or (10327.2) or (10327.1) SUBSYSTEM: Pyruvate metabolism EC Number: 1.1.1.21 Confidence Level: 4 AUTHORS: PMID:12071861,PMID:1537826,PMID:9823300 NOTES:NCD
name: Propane-1,2-diol:NADP+ 1-oxidoreductase
type: Reaction
modifier: MODEL1310110042#
reactant: MODEL1310110042#
reversible: false
kinetic law: MODEL1310110042#
is version of: http://identifiers.org/ec-code/1.1.1.2
is version of: http://identifiers.org/ec-code/1.1.1.21
fast: false
is described by: ECO:0000269

metaM eicostet e
constant: false
is: SBO:0000247
is: CHEBI:36033
name: eicosatetranoic acid
notes: FORMULA: C20H31O2 CHARGE: -1
type: Species
initial concentration: 1.0
boundary condition: false
is: HMDB02177
has only substance units: false
initial amount: NaN

metaR B3GALT3g
reactant: MODEL1310110042#
name: Beta-1,3-galactosyltransferase 3
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/2.4.1.79
product: MODEL1310110042#
reversible: false
kinetic law: MODEL1310110042#
notes: GENE_ASSOCIATION: (8706.4) or (8706.1) or (8706.3) or (8706.2) SUBSYSTEM: Sphingolipid metabolism EC Number: 2.4.1.79 Confidence Level: 4 AUTHORS: NOTES:NJ
is: SBO:0000176
fast: false
type: Reaction
modifier: MODEL1310110042#

metaR r0788
reactant: MODEL1310110042#
type: Reaction
is described by: ECO:0000000
kinetic law: MODEL1310110042#
product: MODEL1310110042#
name: S-Adenosyl-L-methionine:methylethanolamine phosphate N-methyltransferase Glycerophospholipid metabolism EC:2.1.1.103
reversible: true
is: SBO:0000176
fast: false
is version of: http://identifiers.org/ec-code/1.14.13.15
notes: GENE_ASSOCIATION: (1593.1) SUBSYSTEM: Sphingolipid metabolism EC Number: 2.1.1.103 Confidence Level: 0 AUTHORS: PMID:2403362 NOTES:
modifier: MODEL1310110042#

metaM c6dc x
is: SBO:0000247
name: adipoyl carnitine
initial amount: NaN
constant: false
is: C14143
notes: FORMULA: C13H22NO6 CHARGE: -1
is: HMDB04047
initial concentration: 1.0
boundary condition: false
type: Species
has only substance units: false

metaM HC02207 c
boundary condition: false
type: Species
name: prostaglandin-c2
notes: FORMULA: C20H29O4 CHARGE: -1 INCHI: InChI=1S/C20H30O4/c1-2-3-6-9-17(21)14-12-16-13-15-19(22)18(16)10-7-4-5-8-11-20(23)24/h4,7,12-14,17-18,21H,2-3,5-6,8-11,15H2,1H3,(H,23,24)/b7-4-,14-12+/t17-,18+/m0/s1 EHMN_ABBREVIATION: C05955
initial amount: NaN
constant: false
is: CHEBI:27555
initial concentration: 1.0
is: SBO:0000247
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110042#_3d7984e6_66ce_4e72_80ab_e631854badc3
is encoded by: hsa:158
is: SBO:0000252
constant: false
is: P30566
initial amount: NaN
name: ADSL
has only substance units: false
initial concentration: NaN
boundary condition: true
type: Species

http://identifiers.org/biomodels.db/MODEL1310110042#_502059b3_697e_4747_9780_5d68e53c20f0
is: Q7LG56
has only substance units: false
is encoded by: hsa:50484
initial concentration: NaN
is: SBO:0000252
boundary condition: true
initial amount: NaN
type: Species
name: RRM2B
constant: false

http://identifiers.org/biomodels.db/MODEL1310110042#_125fe62d_1a35_47d1_a3ca_50b0fe71d3ae
constant: false
type: Species
name: QDPR
has only substance units: false
initial amount: NaN
is: P09417
initial concentration: NaN
boundary condition: true
is: SBO:0000252
is encoded by: hsa:5860

metaR RE1709N
name: RE1709
type: Reaction
reactant: MODEL1310110042#
is: SBO:0000176
notes: GENE_ASSOCIATION: (5092.1) or (84105.1) SUBSYSTEM: Tetrahydrobiopterin metabolism EC Number: 4.2.1.96 Confidence Level: 0 AUTHORS: PMID:10727395,PMID:8921004 NOTES:
is described by: ECO:0000000
modifier: MODEL1310110042#
reversible: true
is version of: http://identifiers.org/ec-code/4.2.1.96
fast: false
kinetic law: MODEL1310110042#
product: MODEL1310110042#

metaR UREAt5
product: MODEL1310110042#
name: urea, water cotransport
modifier: MODEL1310110042#
reactant: MODEL1310110042#
type: Reaction
notes: GENE_ASSOCIATION: (6523.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:11024018,PMID:11034615,PMID:12748858,PMID:2490366,PMID:8063771 NOTES:NCD
kinetic law: MODEL1310110042#
reversible: true
is described by: ECO:0000269
fast: false
is: SBO:0000185

metaR ENGASE2ly
type: Reaction
reversible: false
is described by: ECO:0000000
is: SBO:0000176
reactant: MODEL1310110042#
kinetic law: MODEL1310110042#
notes: GENE_ASSOCIATION: SUBSYSTEM: N-glycan degradation EC Number: 3.2.1.96 Confidence Level: 0 AUTHORS: NOTES:NCD
fast: false
name: endo-beta-N-acetylglucosaminidase, lysosomal
product: MODEL1310110042#

http://identifiers.org/biomodels.db/MODEL1310110042#_97a3b2be_d92c_4ef5_85e0_c8e87ceef637
is: B1AN63
initial concentration: NaN
is encoded by: hsa:64802
type: Species
constant: false
boundary condition: true
has only substance units: false
initial amount: NaN
name: NMNAT1
is: SBO:0000252

metaR TMNDNCCRNt
product: MODEL1310110042#
is described by: ECO:0000000
name: transport into the mitochondria (carnitine)
modifier: MODEL1310110042#
is: SBO:0000185
type: Reaction
notes: GENE_ASSOCIATION: (788.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: NOTES:NJ
reactant: MODEL1310110042#
reversible: false
fast: false
kinetic law: MODEL1310110042#

http://identifiers.org/biomodels.db/MODEL1310110042#_4b1eea21_ff1b_4dd7_8ebc_11cec19d2761
is encoded by: hsa:113
boundary condition: true
constant: false
initial concentration: NaN
type: Species
is: P51828
has only substance units: false
initial amount: NaN
name: ADCY7
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110042#_560401a3_d2ef_4cdb_acae_8cafc6c93cf3
initial amount: NaN
boundary condition: true
is: SBO:0000252
initial concentration: NaN
type: Species
is: Q6LEN6
constant: false
name: CHAT
has only substance units: false
is encoded by: hsa:1103

metaM hxan c
is: CHEBI:17368
is: SBO:0000247
initial amount: NaN
name: Hypoxanthine
boundary condition: false
initial concentration: 1.0
is: C00262
notes: FORMULA: C5H4N4O CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00238 EHMN_ABBREVIATION: C00262
type: Species
has only substance units: false
constant: false
is: HMDB00157

metaR EX cspg e LPAREN e RPAREN
kinetic law: MODEL1310110042#
reactant: MODEL1310110042#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: chondroitin sulfate E (GalNAc4,6diS-GlcA) proteoglycan exchange
type: Reaction

metaR r0638
product: MODEL1310110042#
type: Reaction
is: SBO:0000176
reactant: MODEL1310110042#
reversible: true
notes: GENE_ASSOCIATION: (4357.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.1.38 Confidence Level: 0 AUTHORS: PMID:12654921 NOTES:
modifier: MODEL1310110042#
name: trans-Dodec-2-enoyl-CoA reductase Fatty acid elongation in mitochondria EC:1.3.1.38
kinetic law: MODEL1310110042#
is version of: http://identifiers.org/ec-code/2.8.1.2
fast: false
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110042#_53b0a7d1_c02d_4060_aa5b_1e5fc4220e4f
is: SBO:0000252
constant: false
is: Q12882
name: DPYD
type: Species
has only substance units: false
initial amount: NaN
is encoded by: hsa:1806
boundary condition: true
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110042#_2c1fa3dd_f677_4621_9d5f_06dc146c7b41
initial amount: NaN
is: P27338
initial concentration: NaN
has only substance units: false
boundary condition: true
is: SBO:0000252
constant: false
name: MAOB
is encoded by: hsa:4129
type: Species

http://identifiers.org/biomodels.db/MODEL1310110042#_24c89096_93fa_4e11_9af5_55aa42415fa2
is: O15357
has only substance units: false
is: SBO:0000252
is encoded by: hsa:3636
initial concentration: NaN
constant: false
type: Species
boundary condition: true
name: INPPL1
initial amount: NaN

metaR r2083
product: MODEL1310110042#
type: Reaction
fast: false
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
is: SBO:0000185
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
reversible: true
kinetic law: MODEL1310110042#
reactant: MODEL1310110042#
is described by: ECO:0000000
modifier: MODEL1310110042#

http://identifiers.org/biomodels.db/MODEL1310110042#_e4edab8f_3c24_4898_a45f_79e315ecead5
name: AMPD3
is encoded by: hsa:272
initial concentration: NaN
has only substance units: false
is: B7Z763
type: Species
initial amount: NaN
boundary condition: true
is: SBO:0000252
constant: false

metaM so4 m
type: Species
has only substance units: false
constant: false
is: HMDB01448
initial amount: NaN
notes: FORMULA: O4S CHARGE: -2 INCHI: InChI=1S/H2O4S/c1-5(2,3)4/h(H2,1,2,3,4)/p-2 HEPATONET_1.0_ABBREVIATION: HC00062 EHMN_ABBREVIATION: C00059
is: SBO:0000247
initial concentration: 1.0
is: CHEBI:16189
name: sulfate
boundary condition: false

metaM ksi pre26 g
has only substance units: false
initial amount: NaN
name: keratan sulfate I biosynthesis, precursor 26
constant: false
boundary condition: false
is: SBO:0000247
type: Species
is: CHEBI:28067
notes: FORMULA: C199H318N14O166S8X CHARGE: -9
initial concentration: 1.0

metaR MTHFDm
is described by: ECO:0000269
is: SBO:0000176
is version of: http://identifiers.org/ec-code/6.3.4.3
modifier: MODEL1310110042#
is version of: http://identifiers.org/ec-code/3.5.4.9
type: Reaction
reversible: true
name: methylenetetrahydrofolate dehydrogenase (NADP), mitochondrial
notes: GENE_ASSOCIATION: (25902.1) or (10797.1) SUBSYSTEM: Folate metabolism EC Number: 1.5.1.5 Confidence Level: 4 AUTHORS: PMID:12937168,PMID:8218174 NOTES:NCD
kinetic law: MODEL1310110042#
reactant: MODEL1310110042#
fast: false
product: MODEL1310110042#

metaR CRNtx
reversible: true
is described by: ECO:0000000
product: MODEL1310110042#
reactant: MODEL1310110042#
kinetic law: MODEL1310110042#
fast: false
name: carnitine transport peroxisome to mitochondria
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: PMID:12814641,PMID:15464416 NOTES:mechanism not currently elucidated NJ
type: Reaction
is: SBO:0000185

metaM dcyt n
is: CHEBI:15698
is: SBO:0000247
boundary condition: false
type: Species
name: 2'-deoxycytidine
initial concentration: 1.0
has only substance units: false
notes: FORMULA: C9H13N3O4 CHARGE: 0 INCHI: InChI=1S/C9H13N3O4/c10-7-1-2-12(9(15)11-7)8-3-5(14)6(4-13)16-8/h1-2,5-6,8,13-14H,3-4H2,(H2,10,11,15)/t5-,6+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00574 EHMN_ABBREVIATION: C00881
constant: false
initial amount: NaN
is: HMDB00014

metaM prostgi2 e
is: HMDB01335
is: SBO:0000247
name: prostaglandin I2(1-)
is: CHEBI:57403
boundary condition: false
type: Species
initial amount: NaN
constant: false
initial concentration: 1.0
notes: FORMULA: C20H31O5 CHARGE: -1 INCHI: InChI=1S/C20H32O5/c1-2-3-4-7-14(21)10-11-16-17-12-15(8-5-6-9-20(23)24)25-19(17)13-18(16)22/h8,10-11,14,16-19,21-22H,2-7,9,12-13H2,1H3,(H,23,24)/p-1/b11-10+,15-8-/t14-,16+,17+,18+,19-/m0/s1 EHMN_ABBREVIATION: C01312
has only substance units: false

metaR r1602
kinetic law: MODEL1310110042#
reactant: MODEL1310110042#
product: MODEL1310110042#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reversible: true
is: SBO:0000185
type: Reaction
is described by: ECO:0000000
fast: false

metaR P45027A11m
is version of: http://identifiers.org/ec-code/1.14.13.15
type: Reaction
reversible: false
product: MODEL1310110042#
notes: GENE_ASSOCIATION: (1593.1) SUBSYSTEM: Bile acid synthesis EC Number: 1.14.13.15 Confidence Level: 4 AUTHORS: NOTES:from uniprot NJ
kinetic law: MODEL1310110042#
is described by: ECO:0000269
reactant: MODEL1310110042#
modifier: MODEL1310110042#
is: SBO:0000176
fast: false
name: 5-beta-cholestane-3-alpha,7-alpha,12-alpha-triol 27-hydroxylase

metaR HSAT3ly
kinetic law: MODEL1310110042#
product: MODEL1310110042#
notes: GENE_ASSOCIATION: SUBSYSTEM: Heparan sulfate degradation EC Number: 2.3.1.78 Confidence Level: 4 AUTHORS: PMID:15591281,PMID:8993162 NOTES:The proton is located in the lysosome since it comes from oxidation of the NH3+ group in glucosamine. This reaction assumes that the other proton liberated from glucosamine reduces coa in the cytosol. NCD
reactant: MODEL1310110042#
name: heparan-glucosaminide N-acetyltransferase, lysosomal
type: Reaction
is: SBO:0000185
fast: false
is described by: ECO:0000000
reversible: false

metaR r0637
product: MODEL1310110042#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.137 Confidence Level: 0 AUTHORS: PMID:1735445,PMID:1988962,PMID:2355017,PMID:6361812,PMID:7892212 NOTES:
reversible: false
reactant: MODEL1310110042#
kinetic law: MODEL1310110042#
is described by: ECO:0000000
name: Octanoyl-CoA:L-carnitine O-octanoyltransferase EC:2.3.1.137
type: Reaction
is: SBO:0000176

metaR r2084
kinetic law: MODEL1310110042#
reactant: MODEL1310110042#
product: MODEL1310110042#
reversible: true
fast: false
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
is described by: ECO:0000000
modifier: MODEL1310110042#
is: SBO:0000185
type: Reaction
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110042#_6cfa73c1_9d18_445a_9f4d_08b60dd96529
has only substance units: false
constant: false
is: O75521
is: SBO:0000252
boundary condition: true
initial concentration: NaN
name: ECI2
type: Species
is encoded by: hsa:10455
initial amount: NaN

metaM dec24dicoa x
is: SBO:0000247
constant: false
initial amount: NaN
type: Species
is: HMDB01168
initial concentration: 1.0
notes: FORMULA: C31H46N7O17P3S CHARGE: -4
name: 2,4-decadienoylcoa
boundary condition: false
has only substance units: false

metaM 13dampp c
boundary condition: false
type: Species
initial concentration: 1.0
is: CHEBI:57484
is: HMDB00002
name: trimethylenediaminium
is: SBO:0000247
initial amount: NaN
has only substance units: false
constant: false
notes: FORMULA: C3H12N2 CHARGE: 2 INCHI: InChI=1S/C3H10N2/c4-2-1-3-5/h1-5H2/p+2 EHMN_ABBREVIATION: C00986

metaR NADtx
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: NOTES:
is described by: ECO:0000134
fast: false
name: transport of NAD into peroxisome
reactant: MODEL1310110042#
kinetic law: MODEL1310110042#
product: MODEL1310110042#
type: Reaction
reversible: true
is: SBO:0000185

metaM mercppyr c
notes: FORMULA: C3H3O3S CHARGE: -1 INCHI: InChI=1S/C3H4O3S/c4-2(1-7)3(5)6/h7H,1H2,(H,5,6)/p-1 HEPATONET_1.0_ABBREVIATION: HC00600 EHMN_ABBREVIATION: C00957
type: Species
initial concentration: 1.0
is: CHEBI:57678
is: HMDB01368
is: SBO:0000247
name: 3-mercaptopyruvate
constant: false
initial amount: NaN
has only substance units: false
boundary condition: false

metaR EX 3ttetddcoacrn
kinetic law: MODEL1310110042#
reactant: MODEL1310110042#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for 3-hydroxy trans5,8tetradecadienoyl carnitine
type: Reaction

metaM xol25oh r
is: SBO:0000247
has only substance units: false
name: 25-hydroxycholesterol
initial amount: NaN
is: HMDB06247
constant: false
type: Species
boundary condition: false
is: CHEBI:42977
initial concentration: 1.0
notes: FORMULA: C27H46O2 CHARGE: 0 INCHI: InChI=1S/C27H46O2/c1-18(7-6-14-25(2,3)29)22-10-11-23-21-9-8-19-17-20(28)12-15-26(19,4)24(21)13-16-27(22,23)5/h8,18,20-24,28-29H,6-7,9-17H2,1-5H3/t18-,20+,21+,22-,23+,24+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01146

metaM hxan e
type: Species
boundary condition: false
notes: FORMULA: C5H4N4O CHARGE: 0 INCHI: InChI=1S/C5H4N4O/c10-5-3-4(7-1-6-3)8-2-9-5/h1-2H,(H2,6,7,8,9,10) HEPATONET_1.0_ABBREVIATION: HC00238 EHMN_ABBREVIATION: C00262
name: hypoxanthine
constant: false
is: HMDB00157
is: SBO:0000247
has only substance units: false
is: CHEBI:17368
initial concentration: 1.0
initial amount: NaN

metaR FE2tm
reactant: MODEL1310110042#
name: iron (II) transport
is described by: ECO:0000000
kinetic law: MODEL1310110042#
fast: false
type: Reaction
is: SBO:0000185
reversible: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: PMID:10383398,PMID:12755454 NOTES:TDV Lange H, 1999.
product: MODEL1310110042#

http://identifiers.org/biomodels.db/MODEL1310110042#_7d756a6e_e701_44b0_9888_94f3ff604722
has only substance units: false
initial amount: NaN
is: SBO:0000252
initial concentration: NaN
type: Species
name: MTHFS
is: P49914
boundary condition: true
is encoded by: hsa:10588
constant: false

metaR r1603
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reversible: true
kinetic law: MODEL1310110042#
type: Reaction
reactant: MODEL1310110042#
product: MODEL1310110042#
is described by: ECO:0000000
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is: SBO:0000185

metaR r2085
kinetic law: MODEL1310110042#
modifier: MODEL1310110042#
product: MODEL1310110042#
fast: false
is: SBO:0000185
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
reactant: MODEL1310110042#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
reversible: true
type: Reaction

metaR RE2996X
product: MODEL1310110042#
name: RE2996
is version of: http://identifiers.org/ec-code/1.3.1.34
is: SBO:0000176
kinetic law: MODEL1310110042#
reversible: true
fast: false
notes: GENE_ASSOCIATION: (26063.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.1.34 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:7775433 NOTES:
is described by: ECO:0000000
type: Reaction
reactant: MODEL1310110042#
modifier: MODEL1310110042#

metaM 2ddecdicoa x
initial amount: NaN
constant: false
boundary condition: false
name: 2,6-dodecadienoylcoa
notes: FORMULA: C33H50N7O17P3S CHARGE: -4
is: SBO:0000247
is: C05279
type: Species
initial concentration: 1.0
has only substance units: false
is: HMDB11123

metaR ACHtn
fast: false
kinetic law: MODEL1310110042#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 1 AUTHORS: NOTES:it
name: Acetylcholin transport, nuclear trhough pores
reversible: true
is described by: ECO:0000000
reactant: MODEL1310110042#
is: SBO:0000185
type: Reaction
product: MODEL1310110042#

http://identifiers.org/biomodels.db/MODEL1310110042#_4aad7045_6578_4591_8240_a87821e1253a
is: SBO:0000252
initial amount: NaN
constant: false
name: ALDOA
type: Species
has only substance units: false
boundary condition: true
is encoded by: hsa:226
initial concentration: NaN
is: P04075

metaM 7dhchsterol r
initial amount: NaN
has only substance units: false
initial concentration: 1.0
boundary condition: false
is: CHEBI:17759
type: Species
name: cholesta-5,7-dien-3beta-ol
is: HMDB00032
is: SBO:0000247
constant: false
notes: FORMULA: C27H44O CHARGE: 0 INCHI: InChI=1S/C27H44O/c1-18(2)7-6-8-19(3)23-11-12-24-22-10-9-20-17-21(28)13-15-26(20,4)25(22)14-16-27(23,24)5/h9-10,18-19,21,23-25,28H,6-8,11-17H2,1-5H3/t19-,21+,23-,24+,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00693 EHMN_ABBREVIATION: C01164

http://identifiers.org/biomodels.db/MODEL1310110042#_4079a1e9_5098_4bb8_9154_3c9a11833ebe
is encoded by: hsa:4245
initial amount: NaN
initial concentration: NaN
boundary condition: true
has only substance units: false
is: P26572
name: MGAT1
constant: false
type: Species
is: SBO:0000252

metaR HS3ly
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/3.10.1.1
fast: false
name: heparan-N-sulfatase, lysosomal
kinetic law: MODEL1310110042#
modifier: MODEL1310110042#
notes: GENE_ASSOCIATION: (6448.1) SUBSYSTEM: Heparan sulfate degradation EC Number: 3.10.1.1 Confidence Level: 4 AUTHORS: PMID:7493035,PMID:8993162,PMID:9405287 NOTES:NCD
is: SBO:0000176
reversible: false
product: MODEL1310110042#
type: Reaction
reactant: MODEL1310110042#

http://identifiers.org/biomodels.db/MODEL1310110042#_6813a334_caa1_4104_8014_c0350569699c
constant: false
initial concentration: NaN
initial amount: NaN
boundary condition: true
name: SULT1A1
type: Species
is encoded by: hsa:6817
is: SBO:0000252
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110042#_c11279a4_b18e_4225_b5c5_3a1ebc89d755
is encoded by: hsa:51095
has only substance units: false
name: TRNT1
initial amount: NaN
boundary condition: true
initial concentration: NaN
is: SBO:0000252
is: Q96Q11
type: Species
constant: false

metaM hmgcoa c
is: SBO:0000247
type: Species
notes: FORMULA: C27H39N7O20P3S CHARGE: -5 INCHI: InChI=1S/C27H44N7O20P3S/c1-26(2,21(40)24(41)30-5-4-15(35)29-6-7-58-17(38)9-27(3,42)8-16(36)37)11-51-57(48,49)54-56(46,47)50-10-14-20(53-55(43,44)45)19(39)25(52-14)34-13-33-18-22(28)31-12-32-23(18)34/h12-14,19-21,25,39-40,42H,4-11H2,1-3H3,(H,29,35)(H,30,41)(H,36,37)(H,46,47)(H,48,49)(H2,28,31,32)(H2,43,44,45)/t14-,19-,20-,21+,25-,27+/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00302 EHMN_ABBREVIATION: C00356
is: CHEBI:15467
constant: false
is: HMDB01375
has only substance units: false
initial concentration: 1.0
boundary condition: false
initial amount: NaN
name: Hydroxymethylglutaryl-CoA

metaR r1604
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reversible: true
fast: false
is: SBO:0000185
product: MODEL1310110042#
type: Reaction
is described by: ECO:0000000
kinetic law: MODEL1310110042#
reactant: MODEL1310110042#

metaM prostgi2 c
boundary condition: false
is: HMDB01335
is: CHEBI:57403
is: SBO:0000247
type: Species
initial concentration: 1.0
notes: FORMULA: C20H31O5 CHARGE: -1 INCHI: InChI=1S/C20H32O5/c1-2-3-4-7-14(21)10-11-16-17-12-15(8-5-6-9-20(23)24)25-19(17)13-18(16)22/h8,10-11,14,16-19,21-22H,2-7,9,12-13H2,1H3,(H,23,24)/p-1/b11-10+,15-8-/t14-,16+,17+,18+,19-/m0/s1 EHMN_ABBREVIATION: C01312
initial amount: NaN
has only substance units: false
constant: false
name: prostaglandin I2(1-)

metaR ATP1ter
type: Reaction
reactant: MODEL1310110042#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: NOTES:NCD
reversible: true
name: ADP/ATP transporter, endoplasmic reticulum
is: SBO:0000185
fast: false
product: MODEL1310110042#
is described by: ECO:0000000
kinetic law: MODEL1310110042#

metaM dtdp c
initial concentration: 1.0
initial amount: NaN
is: C00363
notes: FORMULA: C10H13N2O11P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00307 EHMN_ABBREVIATION: C00363
type: Species
constant: false
boundary condition: false
is: SBO:0000247
is: HMDB01274
has only substance units: false
is: CHEBI:58369
name: dTDP

metaM 3hdeccoa c
is: HMDB02014
type: Species
name: 3-hydroxyhexadecenoylcoa
initial concentration: 1.0
constant: false
has only substance units: false
initial amount: NaN
notes: FORMULA: C37H60N7O18P3S CHARGE: -4
is: SBO:0000247
boundary condition: false

metaR r2086
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
kinetic law: MODEL1310110042#
product: MODEL1310110042#
is described by: ECO:0000000
fast: false
reversible: true
is: SBO:0000185
type: Reaction
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
modifier: MODEL1310110042#
reactant: MODEL1310110042#

metaM dump c
type: Species
initial amount: NaN
notes: FORMULA: C9H11N2O8P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00309 EHMN_ABBREVIATION: C00365
initial concentration: 1.0
name: dUMP
is: CHEBI:246422
has only substance units: false
is: C00365
is: HMDB01409
boundary condition: false
is: SBO:0000247
constant: false

http://identifiers.org/biomodels.db/MODEL1310110042#_924981e7_0d35_43fe_a919_ce105257c3cb
is: P59796
initial concentration: NaN
is encoded by: hsa:257202
boundary condition: true
initial amount: NaN
is: SBO:0000252
type: Species
name: GPX6
constant: false
has only substance units: false

metaM ksi pre22 g
name: keratan sulfate I biosynthesis, precursor 22
initial concentration: 1.0
boundary condition: false
is: C00130
initial amount: NaN
has only substance units: false
is: CHEBI:58053
is: HMDB00175
notes: FORMULA: C185H297N13O150S6X CHARGE: -7
constant: false
type: Species
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110042#_36a4a9fe_7578_4c01_944a_dc679e609e85
initial amount: NaN
name: PIK3R1
constant: false
is: P27986
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:5295
type: Species
boundary condition: true
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110042#_e8935d72_c7e5_401b_8a2c_0f01baecf57d
initial concentration: NaN
is: P22033
is: SBO:0000252
name: MUT
initial amount: NaN
has only substance units: false
constant: false
type: Species
boundary condition: true
is encoded by: hsa:4594

metaR r2092
is described by: ECO:0000000
is: SBO:0000185
reactant: MODEL1310110042#
type: Reaction
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
modifier: MODEL1310110042#
fast: false
reversible: true
kinetic law: MODEL1310110042#
product: MODEL1310110042#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1

metaR D3AIBTm
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Pyrimidine catabolism EC Number: 2.6.1.40 Confidence Level: 4 AUTHORS: PMID:5773299 NOTES:MM
reactant: MODEL1310110042#
is described by: ECO:0000000
type: Reaction
product: MODEL1310110042#
name: D-3-Amino-isobutanoate:pyruvate aminotransferase, mitochondrial
reversible: true
kinetic law: MODEL1310110042#
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110042#_f275622e_f94d_422c_a88a_a2c14d60edfa
initial amount: NaN
name: ALOX5
is: P09917
boundary condition: true
is encoded by: hsa:240
type: Species
has only substance units: false
initial concentration: NaN
is: SBO:0000252
constant: false

metaR ABUTt2r
fast: false
name: 4-aminobutyrate reversible transport in via proton symport
type: Reaction
reversible: true
is described by: ECO:0000304
modifier: MODEL1310110042#
product: MODEL1310110042#
reactant: MODEL1310110042#
notes: GENE_ASSOCIATION: (206358.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11390972,PMID:11959859 NOTES:SAB r
kinetic law: MODEL1310110042#
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110042#_39b9557c_9f82_469a_8fea_854d51a6c7a9
has only substance units: false
is: SBO:0000252
initial concentration: NaN
name: GMPR2
is encoded by: hsa:51292
initial amount: NaN
boundary condition: true
is: Q86T14
type: Species
constant: false

http://identifiers.org/biomodels.db/MODEL1310110042#_62baaf10_8bd8_4334_a6fe_f78c06d1089d
is: P23786
initial concentration: NaN
constant: false
is: SBO:0000252
is encoded by: hsa:1376
initial amount: NaN
boundary condition: true
has only substance units: false
name: CPT2
type: Species

metaR ASPTA
name: aspartate transaminase
is described by: ECO:0000269
is: SBO:0000176
reversible: true
product: MODEL1310110042#
reactant: MODEL1310110042#
notes: GENE_ASSOCIATION: (2805.1) SUBSYSTEM: Alanine and aspartate metabolism EC Number: 2.6.1.1 Confidence Level: 4 AUTHORS: PMID:2225456,PMID:6930651 NOTES:
is version of: http://identifiers.org/ec-code/2.6.1.1
fast: false
kinetic law: MODEL1310110042#
modifier: MODEL1310110042#
type: Reaction

metaR IDOAASE2ly
is version of: http://identifiers.org/ec-code/3.2.1.76
name: alpha-L-iduronidase, lysosomal
is described by: ECO:0000000
is: SBO:0000176
modifier: MODEL1310110042#
reactant: MODEL1310110042#
kinetic law: MODEL1310110042#
reversible: false
type: Reaction
product: MODEL1310110042#
notes: GENE_ASSOCIATION: (3425.1) SUBSYSTEM: Heparan sulfate degradation EC Number: 3.2.1.76 Confidence Level: 4 AUTHORS: PMID:1946389,PMID:2470345 NOTES:NCD
fast: false

http://identifiers.org/biomodels.db/MODEL1310110042#_bb7ba0ae_1eef_44b2_a179_566a5454bd29
initial concentration: NaN
name: PLCZ1
is: Q86YW0
is: SBO:0000252
has only substance units: false
initial amount: NaN
is encoded by: hsa:89869
constant: false
boundary condition: true
type: Species

metaR r1937
type: Reaction
modifier: MODEL1310110042#
name: Y+LAT2 Utilized transport
product: MODEL1310110042#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is: SBO:0000185
fast: false
reversible: false
reactant: MODEL1310110042#
kinetic law: MODEL1310110042#

http://identifiers.org/biomodels.db/MODEL1310110042#_dad8aeb3_db93_485d_acc2_11e18fbbe74d
initial amount: NaN
type: Species
name: SLC25A20
initial concentration: NaN
constant: false
is: O43772
is: SBO:0000252
is encoded by: hsa:788
has only substance units: false
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110042#_8fe57033_a421_467a_8bf9_9db05c5260a1
boundary condition: true
is: SBO:0000252
constant: false
name: NDUFV2
is encoded by: hsa:4729
type: Species
is: P19404
initial concentration: NaN
initial amount: NaN
has only substance units: false

metaR ETOHt
product: MODEL1310110042#
type: Reaction
is: SBO:0000185
fast: false
kinetic law: MODEL1310110042#
name: ethanol reversible transport
is described by: ECO:0000000
reactant: MODEL1310110042#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: NOTES:NCD
reversible: true

metaR r2091
product: MODEL1310110042#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
modifier: MODEL1310110042#
type: Reaction
reversible: true
is: SBO:0000185
reactant: MODEL1310110042#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
fast: false
kinetic law: MODEL1310110042#
is described by: ECO:0000000

metaR DCTPtn
product: MODEL1310110042#
type: Reaction
fast: false
is: SBO:0000185
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: NOTES:IT
reversible: true
kinetic law: MODEL1310110042#
name: dCTP diffusion in nucleus
reactant: MODEL1310110042#

metaM gln L c
is: HMDB00641
constant: false
has only substance units: false
is: CHEBI:18050
initial amount: NaN
type: Species
initial concentration: 1.0
is: SBO:0000247
notes: FORMULA: C5H10N2O3 CHARGE: 0 INCHI: InChI=1S/C5H10N2O3/c6-3(5(9)10)1-2-4(7)8/h3H,1-2,6H2,(H2,7,8)(H,9,10)/t3-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00067
name: L-glutamine
boundary condition: false

metaR GGH 10FTHF6GLUe
kinetic law: MODEL1310110042#
modifier: MODEL1310110042#
reactant: MODEL1310110042#
product: MODEL1310110042#
type: Reaction
name: Gamma-glutamyl hydrolase (10FTHF6GLU), extracellular
reversible: false
notes: GENE_ASSOCIATION: (8836.1) SUBSYSTEM: Folate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:11375437,PMID:2867095,PMID:9614206 NOTES:REMOVES EITHER ONE OR TWO GLUTAMYL RESIDUES WITH A REACTION (WILL ONLY REPRESENT 1) IT
is version of: http://identifiers.org/ec-code/3.4.19.9
is: SBO:0000176
fast: false
is described by: ECO:0000000

metaR NACHEX16ly
is described by: ECO:0000000
fast: false
is: SBO:0000176
reversible: false
type: Reaction
is version of: http://identifiers.org/ec-code/3.2.1.52
modifier: MODEL1310110042#
product: MODEL1310110042#
reactant: MODEL1310110042#
kinetic law: MODEL1310110042#
name: beta-N-acetylhexosaminidase, lysosomal
notes: GENE_ASSOCIATION: (3073.1 and 3074.1) or (3074.1) or (3073.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.52 Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12706724,PMID:8993162 NOTES:NCD

metaR r0791
name: trans-Hex-2-enoyl-CoA reductase Fatty acid elongation in mitochondria EC:1.3.1.38
kinetic law: MODEL1310110042#
reactant: MODEL1310110042#
modifier: MODEL1310110042#
fast: false
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/1.1.1.35
reversible: true
product: MODEL1310110042#
type: Reaction
is version of: http://identifiers.org/ec-code/4.2.1.107
notes: GENE_ASSOCIATION: (1962.1) or (3033.1) or (3028.1) or (3295.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.1.38 Confidence Level: 0 AUTHORS: PMID:12654921 NOTES:
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110042#_fde957fa_a3c5_4790_8ad4_67a4771ce540
constant: false
is: SBO:0000252
boundary condition: true
initial amount: NaN
type: Species
name: IMPA2
is encoded by: hsa:3613
is: O14732
has only substance units: false
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110042#_c47969d3_3e29_4d0b_9a22_dbd9843d1386
boundary condition: true
has only substance units: false
initial amount: NaN
initial concentration: NaN
name: _R06874_1_r
type: Species
is encoded by: hsa:R06874
constant: false
is: SBO:0000252

metaM xol7a r
constant: false
initial concentration: 1.0
has only substance units: false
is: SBO:0000247
type: Species
name: 20-hydroxycholesterol
initial amount: NaN
is: CHEBI:1296
boundary condition: false
notes: FORMULA: C27H46O2 CHARGE: 0 INCHI: InChI=1S/C27H46O2/c1-18(2)7-6-14-27(5,29)24-11-10-22-21-9-8-19-17-20(28)12-15-25(19,3)23(21)13-16-26(22,24)4/h8,18,20-24,28-29H,6-7,9-17H2,1-5H3/t20-,21-,22-,23-,24-,25-,26-,27-/m0/s1 EHMN_ABBREVIATION: C03594
is: HMDB01496

metaM dudp c
notes: FORMULA: C9H11N2O11P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00768 EHMN_ABBREVIATION: C01346
is: SBO:0000247
name: dUDP
boundary condition: false
has only substance units: false
is: HMDB01000
initial concentration: 1.0
type: Species
is: CHEBI:60471
is: C01346
constant: false
initial amount: NaN

metaR GMPtg
reactant: MODEL1310110042#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, golgi apparatus EC Number: 6.3.5.2 Confidence Level: 1 AUTHORS: PMID:7706277 NOTES:
is described by: ECO:0000269
reversible: true
kinetic law: MODEL1310110042#
fast: false
type: Reaction
product: MODEL1310110042#
is: SBO:0000185
name: GMP transport (Golgi)

metaR CYTDK2m
type: Reaction
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 1 AUTHORS: NOTES:IT
is described by: ECO:0000000
product: MODEL1310110042#
reversible: false
reactant: MODEL1310110042#
is: SBO:0000176
name: cytidine kinase (ATP), mitochondrial
kinetic law: MODEL1310110042#

metaM sph1p c
notes: FORMULA: C18H39NO5P CHARGE: -1 INCHI: InChI=1S/C18H40NO5P/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-18(20)17(19)16-24-25(21,22)23/h17-18,20H,2-16,19H2,1H3,(H2,21,22,23)/p-1/t17-,18+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00675 EHMN_ABBREVIATION: C01120
initial concentration: 1.0
name: (2S,3R)-2-azaniumyl-3-hydroxyoctadecyl phosphate
type: Species
is: SBO:0000247
constant: false
initial amount: NaN
is: HMDB01383
has only substance units: false
boundary condition: false
is: CHEBI:57939

metaM ksi deg31 l
is: SBO:0000247
name: keratan sulfate I, degradation product 31
is: HMDB00812
has only substance units: false
initial amount: NaN
initial concentration: 1.0
notes: FORMULA: C90H148N6O72S2 CHARGE: -2
constant: false
is: CHEBI:16953
type: Species
boundary condition: false

metaM zym int2 r
initial amount: NaN
has only substance units: false
initial concentration: 1.0
is: CHEBI:52386
name: zymosterol intermediate 2
boundary condition: false
type: Species
is: SBO:0000247
constant: false
notes: FORMULA: C27H42O CHARGE: 0 INCHI: InChI=1S/C27H42O/c1-18(2)7-6-8-19(3)23-11-12-24-22-10-9-20-17-21(28)13-15-26(20,4)25(22)14-16-27(23,24)5/h7,19-20,23-24H,6,8-17H2,1-5H3/t19-,20+,23-,24+,26+,27-/m1/s1

metaR r2094
fast: false
reversible: true
type: Reaction
product: MODEL1310110042#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
kinetic law: MODEL1310110042#
reactant: MODEL1310110042#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
modifier: MODEL1310110042#
is: SBO:0000185
is described by: ECO:0000000

metaR EX asp L LPAREN e RPAREN
kinetic law: MODEL1310110042#
reactant: MODEL1310110042#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: L-Aspartate exchange
type: Reaction

metaM hmgcoa x
is: SBO:0000247
constant: false
initial amount: NaN
notes: FORMULA: C27H39N7O20P3S CHARGE: -5 INCHI: InChI=1S/C27H44N7O20P3S/c1-26(2,21(40)24(41)30-5-4-15(35)29-6-7-58-17(38)9-27(3,42)8-16(36)37)11-51-57(48,49)54-56(46,47)50-10-14-20(53-55(43,44)45)19(39)25(52-14)34-13-33-18-22(28)31-12-32-23(18)34/h12-14,19-21,25,39-40,42H,4-11H2,1-3H3,(H,29,35)(H,30,41)(H,36,37)(H,46,47)(H,48,49)(H2,28,31,32)(H2,43,44,45)/t14-,19-,20-,21+,25-,27+/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00302 EHMN_ABBREVIATION: C00356
boundary condition: false
initial concentration: 1.0
is: CHEBI:15467
name: Hydroxymethylglutaryl-CoA
has only substance units: false
type: Species
is: HMDB01375

http://identifiers.org/biomodels.db/MODEL1310110042#_a6606c61_0b8b_4ddb_8039_5ae104752644
is encoded by: hsa:7915
type: Species
constant: false
name: ALDH5A1
is: Q546H9
is: SBO:0000252
has only substance units: false
initial concentration: NaN
initial amount: NaN
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110042#_6935b67a_506b_4241_9890_4ea564bcdd51
is: SBO:0000252
constant: false
initial concentration: NaN
name: SOD2
boundary condition: true
type: Species
initial amount: NaN
has only substance units: false
is encoded by: hsa:6648
is: P04179

metaR r0792
product: MODEL1310110042#
is version of: http://identifiers.org/ec-code/4.2.1.107
modifier: MODEL1310110042#
is described by: ECO:0000000
kinetic law: MODEL1310110042#
reversible: true
reactant: MODEL1310110042#
name: 5-methyltetrahydrofolate:NAD+ oxidoreductase One carbon pool by folate / Methane metabolism EC:1.5.1.20
type: Reaction
is: SBO:0000176
fast: false
notes: GENE_ASSOCIATION: (3295.1) SUBSYSTEM: Folate metabolism EC Number: 1.5.1.20 Confidence Level: 0 AUTHORS: PMID:1119805,PMID:2383427 NOTES:

metaR GALASE4ly
reactant: MODEL1310110042#
is version of: http://identifiers.org/ec-code/3.2.1.23
product: MODEL1310110042#
is version of: http://identifiers.org/ec-code/3.2.1.18
is version of: http://identifiers.org/ec-code/3.1.6.4
is described by: ECO:0000000
is: SBO:0000176
reversible: false
type: Reaction
modifier: MODEL1310110042#
name: beta-galactosidase, lysosomal
is version of: http://identifiers.org/ec-code/3.4.16.5
kinetic law: MODEL1310110042#
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) or (5476.1) and (2720.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.23 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD
fast: false

http://identifiers.org/biomodels.db/MODEL1310110042#_dfc6b10a_9391_44a4_8688_b695e4a2371b
boundary condition: true
is: Q53Y83
name: GLA
type: Species
has only substance units: false
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:2717
initial concentration: NaN
constant: false

metaR r2093
type: Reaction
kinetic law: MODEL1310110042#
product: MODEL1310110042#
is: SBO:0000185
reactant: MODEL1310110042#
reversible: true
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
modifier: MODEL1310110042#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
is described by: ECO:0000000
fast: false

metaM hxcoa c
is: HMDB13130
has only substance units: false
boundary condition: false
constant: false
initial amount: NaN
name: Hexanoyl-CoA (n-C6:0CoA)
notes: FORMULA: C27H42N7O17P3S CHARGE: -4
is: SBO:0000247
type: Species
initial concentration: 1.0

metaM dec24dicoa m
boundary condition: false
initial amount: NaN
type: Species
is: SBO:0000247
has only substance units: false
initial concentration: 1.0
name: 2,4-decadienoylcoa
is: HMDB01168
constant: false
notes: FORMULA: C31H46N7O17P3S CHARGE: -4

http://identifiers.org/biomodels.db/MODEL1310110042#_04599402_cb6e_48fe_a47f_d5f0068b6795
initial amount: NaN
name: SLC2A4
constant: false
is: P14672
boundary condition: true
has only substance units: false
initial concentration: NaN
is: SBO:0000252
type: Species
is encoded by: hsa:6517

http://identifiers.org/biomodels.db/MODEL1310110042#_aad1faa8_9415_413d_b125_50635ae989c3
is encoded by: hsa:23236
is: SBO:0000252
name: PLCB1
initial amount: NaN
constant: false
is: Q9NQ66
boundary condition: true
has only substance units: false
type: Species
initial concentration: NaN

metaR DCK1n
reversible: true
notes: GENE_ASSOCIATION: (1633.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.1.74 Confidence Level: 4 AUTHORS: PMID:10387103,PMID:12535661,PMID:9342341 NOTES:IT (2.7.1.74)
modifier: MODEL1310110042#
type: Reaction
product: MODEL1310110042#
is version of: http://identifiers.org/ec-code/2.7.1.74
fast: false
reactant: MODEL1310110042#
is: SBO:0000176
kinetic law: MODEL1310110042#
is described by: ECO:0000269
name: Deoxycytidine kinase, nuclear (ATP)

metaR XOL7AH2tm
fast: false
reactant: MODEL1310110042#
product: MODEL1310110042#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: PMID:12840657 NOTES:cholesterol precursor, transport by "diffusion" -> actually beleived to be flip-flop mechanism (PMID: 12840657). NJ
type: Reaction
name: lipid, flip-flop intracellular transport
is: SBO:0000185
is described by: ECO:0000000
reversible: true
kinetic law: MODEL1310110042#

http://identifiers.org/biomodels.db/MODEL1310110042#_776925d1_2e5e_461c_b2d2_ae9c719a90b4
name: SLC4A5
is: SBO:0000252
boundary condition: true
initial amount: NaN
type: Species
is encoded by: hsa:57835
has only substance units: false
initial concentration: NaN
constant: false

metaM so3 c
name: Sulfite
initial concentration: 1.0
type: Species
notes: FORMULA: O3S CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00096 EHMN_ABBREVIATION: C00094
initial amount: NaN
is: CHEBI:17137
is: C00094
is: HMDB00240
boundary condition: false
is: SBO:0000247
constant: false
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110042#_cbda8d75_78a5_4fd4_96c7_14a5e7d886b8
is encoded by: hsa:7296
initial concentration: NaN
name: TXNRD1
constant: false
is: SBO:0000252
boundary condition: true
initial amount: NaN
has only substance units: false
type: Species
is: Q16881

http://identifiers.org/biomodels.db/MODEL1310110042#_910055a9_18f3_42ee_b65b_a235cc679d76
is encoded by: hsa:5294
is: SBO:0000252
name: PIK3CG
has only substance units: false
is: P48736
initial concentration: NaN
boundary condition: true
type: Species
constant: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110042#_33da8906_5a8f_4eff_a86e_9538cf2817fd
is: P17516
is encoded by: hsa:1109
initial amount: NaN
is: SBO:0000252
name: AKR1C4
boundary condition: true
has only substance units: false
initial concentration: NaN
type: Species
constant: false

metaM pail5p hs n
boundary condition: false
initial amount: NaN
has only substance units: false
is: SBO:0000247
constant: false
is: CHEBI:57795
notes: FORMULA: C9H15O12P2FULLRCO2FULLR2CO2 CHARGE: -3
type: Species
name: 1-phosphatidyl-1D-myo-inositol 5-phosphate(3-)
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110042#_e5beb35b_b17f_4284_a9bc_51996843a4e1
is encoded by: hsa:1719
has only substance units: false
initial amount: NaN
type: Species
is: SBO:0000252
boundary condition: true
is: P00374
name: DHFR
constant: false
initial concentration: NaN

metaM dutp n
is: SBO:0000247
boundary condition: false
initial amount: NaN
name: dUTP
has only substance units: false
notes: FORMULA: C9H11N2O14P3 CHARGE: -4 INCHI: InChI=1S/C9H15N2O14P3/c12-5-3-8(11-2-1-7(13)10-9(11)14)23-6(5)4-22-27(18,19)25-28(20,21)24-26(15,16)17/h1-2,5-6,8,12H,3-4H2,(H,18,19)(H,20,21)(H,10,13,14)(H2,15,16,17)/t5-,6+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00369 EHMN_ABBREVIATION: C00460
constant: false
type: Species
initial concentration: 1.0
is: CHEBI:17625
is: HMDB01191

http://identifiers.org/biomodels.db/MODEL1310110042#_9bfb370a_3ff0_4d1e_9df6_07a3882f5cee
constant: false
is encoded by: hsa:4952
has only substance units: false
is: SBO:0000252
type: Species
initial concentration: NaN
boundary condition: true
name: OCRL
initial amount: NaN
is: Q01968

http://identifiers.org/biomodels.db/MODEL1310110042#_6187ba51_ef31_424f_a2db_d99c1bad04f8
is encoded by: hsa:10935
name: PRDX3
is: SBO:0000252
type: Species
is: P30048
initial amount: NaN
has only substance units: false
constant: false
initial concentration: NaN
boundary condition: true

metaR EX ppi LPAREN e RPAREN
kinetic law: MODEL1310110042#
reactant: MODEL1310110042#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for ppi
type: Reaction

metaR S2TASE3ly
fast: false
type: Reaction
product: MODEL1310110042#
is described by: ECO:0000000
modifier: MODEL1310110042#
is: SBO:0000176
name: iduronate-2-sulfatase, lysosomal
notes: GENE_ASSOCIATION: (3423.2) or (3423.1) SUBSYSTEM: Chondroitin sulfate degradation EC Number: 3.1.6.13 Confidence Level: 4 AUTHORS: PMID:2122463,PMID:8244397,PMID:8530090,PMID:8993162 NOTES:NCD
reversible: false
reactant: MODEL1310110042#
kinetic law: MODEL1310110042#
is version of: http://identifiers.org/ec-code/3.1.6.13

metaR FAOXC5C3x
kinetic law: MODEL1310110042#
product: MODEL1310110042#
reactant: MODEL1310110042#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C5-->C3)m
type: Reaction

metaM ala B e
initial concentration: 1.0
initial amount: NaN
name: beta-alanine
is: CHEBI:16958
is: HMDB00056
constant: false
notes: FORMULA: C3H7NO2 CHARGE: 0 INCHI: InChI=1S/C3H7NO2/c4-2-1-3(5)6/h1-2,4H2,(H,5,6) HEPATONET_1.0_ABBREVIATION: HC00100
type: Species
is: SBO:0000247
boundary condition: false
has only substance units: false

metaM 2hexdtetcoa m
initial concentration: 1.0
boundary condition: false
constant: false
name: 2,7,10,13-hexadecatetraenoylcoa
is: HMDB02288
has only substance units: false
is: SBO:0000247
initial amount: NaN
type: Species
notes: FORMULA: C37H54N7O17P3S CHARGE: -4

metaR EX arach LPAREN e RPAREN
kinetic law: MODEL1310110042#
reactant: MODEL1310110042#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for arachidate
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110042#_5fcc54ba_fbd8_4dd5_b8fd_35dcbbfc712f
initial amount: NaN
is: SBO:0000252
has only substance units: false
name: GCAT
boundary condition: true
constant: false
is encoded by: hsa:23464
type: Species
initial concentration: NaN
is: E2QC23

http://identifiers.org/biomodels.db/MODEL1310110042#_059ca9fe_906f_42a6_8242_8878e644c672
initial amount: NaN
is: Q6IBC0
has only substance units: false
constant: false
name: HMGCL
boundary condition: true
type: Species
is encoded by: hsa:3155
is: SBO:0000252
initial concentration: NaN

metaM HC01223 m
constant: false
name: 3-hydroxy-2-methylpropanoyl-CoA(4-)
is: SBO:0000247
has only substance units: false
type: Species
is: CHEBI:57340
initial amount: NaN
initial concentration: 1.0
notes: FORMULA: C25H38N7O18P3S CHARGE: -4 INCHI: InChI=1S/C25H42N7O18P3S/c1-13(8-33)24(38)54-7-6-27-15(34)4-5-28-22(37)19(36)25(2,3)10-47-53(44,45)50-52(42,43)46-9-14-18(49-51(39,40)41)17(35)23(48-14)32-12-31-16-20(26)29-11-30-21(16)32/h11-14,17-19,23,33,35-36H,4-10H2,1-3H3,(H,27,34)(H,28,37)(H,42,43)(H,44,45)(H2,26,29,30)(H2,39,40,41)/p-4/t13?,14-,17-,18-,19+,23-/m1/s1 EHMN_ABBREVIATION: C04047
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110042#_2378e1a6_4435_4382_8327_e55d0384548c
boundary condition: true
type: Species
initial amount: NaN
has only substance units: false
constant: false
is encoded by: hsa:204
initial concentration: NaN
name: AK2
is: SBO:0000252

metaM dgchol c
notes: FORMULA: C26H43NO5 CHARGE: 0 INCHI: InChI=1S/C26H43NO5/c1-15(4-7-22(30)27-14-23(31)32)18-5-6-19-24-20(9-11-26(18,19)3)25(2)10-8-17(28)12-16(25)13-21(24)29/h15-21,24,28-29H,4-14H2,1-3H3,(H,27,30)(H,31,32)/p-1/t15-,16+,17-,18-,19+,20+,21-,24+,25+,26-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01472
boundary condition: false
has only substance units: false
is: SBO:0000247
is: CHEBI:36252
constant: false
initial concentration: 1.0
initial amount: NaN
type: Species
name: glycochenodeoxycholate
is: HMDB00637

http://identifiers.org/biomodels.db/MODEL1310110042#_f7cb77a6_359f_4480_9e8e_4cecc1cbabc7
type: Species
constant: false
initial concentration: NaN
is encoded by: hsa:513
is: P30049
is: SBO:0000252
boundary condition: true
initial amount: NaN
name: ATP5D
has only substance units: false

metaR FAOXC13C11m
kinetic law: MODEL1310110042#
product: MODEL1310110042#
reactant: MODEL1310110042#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C13-->C11)m
type: Reaction

metaM g3pc c
type: Species
is: CHEBI:16870
constant: false
boundary condition: false
has only substance units: false
initial concentration: 1.0
initial amount: NaN
is: HMDB00086
notes: FORMULA: C8H20NO6P CHARGE: 0 INCHI: InChI=1S/C8H20NO6P/c1-9(2,3)4-5-14-16(12,13)15-7-8(11)6-10/h8,10-11H,4-7H2,1-3H3/p+1/t8-/m1/s1 EHMN_ABBREVIATION: C00670
name: sn-Glycero-3-phosphocholine
is: SBO:0000247

metaR EX HC01104 LPAREN e RPAREN
kinetic law: MODEL1310110042#
reactant: MODEL1310110042#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of 4-nitrophenyl phosphate(2-)
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110042#_8e2ea657_42a2_43d9_9477_4832c27e6a69
boundary condition: true
initial concentration: NaN
has only substance units: false
initial amount: NaN
is: SBO:0000252
is: B4DJQ3
constant: false
is encoded by: hsa:6472
type: Species
name: SHMT2

metaR EX 34hpp
kinetic law: MODEL1310110042#
reactant: MODEL1310110042#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: Exchange of 3-(4-hydroxyphenyl)pyruvate
type: Reaction

metaM C05957 r
boundary condition: false
is: CHEBI:27485
name: Prostaglandin J2
constant: false
initial concentration: 1.0
is: SBO:0000247
has only substance units: false
type: Species
notes: FORMULA: C20H29O4 CHARGE: -1 INCHI: InChI=1S/C20H30O4/c1-2-3-6-10-17(21)13-14-18-16(12-15-19(18)22)9-7-4-5-8-11-20(23)24/h4,7,12-18,21H,2-3,5-6,8-11H2,1H3,(H,23,24)/b7-4-,14-13+/t16-,17-,18+/m0/s1 EHMN_ABBREVIATION: C05957
initial amount: NaN
is: HMDB02710

metaM vacc c
is: C08367
is: CHEBI:30828
has only substance units: false
boundary condition: false
type: Species
initial concentration: 1.0
name: trans-vaccenate
is: SBO:0000247
notes: FORMULA: C18H33O2 CHARGE: -1 INCHI: InChI=1S/C18H34O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20/h7-8H,2-6,9-17H2,1H3,(H,19,20)/p-1/b8-7+
initial amount: NaN
constant: false

http://identifiers.org/biomodels.db/MODEL1310110042#_984d0d4e_b623_4cf6_93f2_f8b412307c37
is: SBO:0000297
name: IDH3A:IDH3B:IDH3G
is encoded by: hsa:3420
has only substance units: false
initial concentration: NaN
initial amount: NaN
constant: false
boundary condition: true
type: Species

metaM dolp L r
is: SBO:0000247
type: Species
has only substance units: false
initial concentration: 1.0
initial amount: NaN
boundary condition: false
name: dolichyl phosphate(2-)
notes: FORMULA: C1080H1758O40P10 CHARGE: -20 INCHI: InChI=1S/C25H45O4P/c1-21(2)11-7-12-22(3)13-8-14-23(4)15-9-16-24(5)17-10-18-25(6)19-20-29-30(26,27)28/h11,13,15,17,25H,7-10,12,14,16,18-20H2,1-6H3,(H2,26,27,28)/p-2/b22-13+,23-15+,24-17- EHMN_ABBREVIATION: C00110
is: CHEBI:57683
constant: false

metaR EX gchola LPAREN e RPAREN
kinetic law: MODEL1310110042#
reactant: MODEL1310110042#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Glycocholate exchange
type: Reaction

metaM lpam m
initial concentration: 1.0
is: HMDB00962
notes: FORMULA: C8H15NOS2 CHARGE: 0 INCHI: InChI=1S/C8H15NOS2/c9-8(10)4-2-1-3-7-5-6-11-12-7/h7H,1-6H2,(H2,9,10) HEPATONET_1.0_ABBREVIATION: HC00225 EHMN_ABBREVIATION: C00248
has only substance units: false
boundary condition: false
name: lipoamide
is: CHEBI:17460
type: Species
is: SBO:0000247
constant: false
initial amount: NaN

metaM c6dc c
is: HMDB00705
constant: false
has only substance units: false
name: adipoyl carnitine
type: Species
initial amount: NaN
is: SBO:0000247
initial concentration: 1.0
boundary condition: false
notes: FORMULA: C13H22NO6 CHARGE: -1

metaR TDCRNe
kinetic law: MODEL1310110042#
product: MODEL1310110042#
reactant: MODEL1310110042#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of myristoyl carnitine into extra cellular space
type: Reaction

metaR r0796
modifier: MODEL1310110042#
fast: false
kinetic law: MODEL1310110042#
type: Reaction
is described by: ECO:0000000
product: MODEL1310110042#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.2.1.5
reactant: MODEL1310110042#
name: Ribitol:NAD+ 2-oxidoreductase Pentose and glucuronate interconversions EC:1.1.1.56
notes: GENE_ASSOCIATION: (220.1) or (218.1) or (221.1) or (222.1) or (U37519.1) SUBSYSTEM: Pentose phosphate pathway EC Number: Confidence Level: 0 AUTHORS: PMID:15234337 NOTES:
reversible: true

metaM omhpal c
type: Species
has only substance units: false
is: HMDB06294
initial amount: NaN
name: w-hydroxypalmiticacid
boundary condition: false
constant: false
is: SBO:0000247
initial concentration: 1.0
notes: FORMULA: C16H30O3 CHARGE: -1

metaR r2090
reactant: MODEL1310110042#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
type: Reaction
is: SBO:0000185
reversible: true
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
modifier: MODEL1310110042#
fast: false
product: MODEL1310110042#
kinetic law: MODEL1310110042#
is described by: ECO:0000000

metaR ORPT
notes: GENE_ASSOCIATION: (7372.1) SUBSYSTEM: Pyrimidine synthesis EC Number: 2.4.2.10 Confidence Level: 4 AUTHORS: PMID:3279416,PMID:6574608,PMID:6893554,PMID:9042911 NOTES:
name: orotate phosphoribosyltransferase
modifier: MODEL1310110042#
is: SBO:0000176
type: Reaction
kinetic law: MODEL1310110042#
is described by: ECO:0000269
product: MODEL1310110042#
reversible: true
fast: false
reactant: MODEL1310110042#
is version of: http://identifiers.org/ec-code/2.4.2.10

metaM ksii core2 pre1 g
is: CHEBI:28067
initial concentration: 1.0
name: keratan sulfate II biosynthesis, precursor 1
initial amount: NaN
constant: false
notes: FORMULA: C33H53N3O23X CHARGE: -1
has only substance units: false
is: SBO:0000247
boundary condition: false
type: Species

metaR VALTAm
is described by: ECO:0000269
fast: false
is: SBO:0000176
reversible: true
is version of: http://identifiers.org/ec-code/2.6.1.42
modifier: MODEL1310110042#
notes: GENE_ASSOCIATION: (587.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 2.6.1.42 Confidence Level: 4 AUTHORS: PMID:6933702,PMID:9165094 NOTES:NCD
product: MODEL1310110042#
type: Reaction
reactant: MODEL1310110042#
name: valine transaminase, mitochondiral
kinetic law: MODEL1310110042#

http://identifiers.org/biomodels.db/MODEL1310110042#_6aeddbec_faa8_4595_88f6_ad74bee49bbe
boundary condition: true
type: Species
constant: false
is encoded by: hsa:1718
is: SBO:0000252
is: Q15392
name: DHCR24
initial concentration: NaN
initial amount: NaN
has only substance units: false

metaM hs deg11 l
has only substance units: false
initial concentration: 1.0
initial amount: NaN
notes: FORMULA: C55H81N3O67S7 CHARGE: -8
is: SBO:0000247
boundary condition: false
name: heparan sulfate, degradation product 11
type: Species
constant: false
is: CHEBI:57737
is: HMDB00868

metaR PTDCAt
reversible: true
name: fatty acid transport via diffusion
reactant: MODEL1310110042#
product: MODEL1310110042#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:NJ
is: SBO:0000185
fast: false
kinetic law: MODEL1310110042#
is described by: ECO:0000000
type: Reaction

metaM ksi deg7 l
name: keratan sulfate I, degradation product 7
constant: false
is: CHEBI:16953
type: Species
boundary condition: false
initial concentration: 1.0
is: SBO:0000247
initial amount: NaN
is: HMDB00812
notes: FORMULA: C210H337N15O181S10 CHARGE: -10
has only substance units: false

metaR FAOXC9C7m
kinetic law: MODEL1310110042#
product: MODEL1310110042#
reactant: MODEL1310110042#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C9-->C7)m
type: Reaction

metaR HPDCAt
kinetic law: MODEL1310110042#
name: fatty acid transport via diffusion
type: Reaction
product: MODEL1310110042#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:NJ
is: SBO:0000185
is described by: ECO:0000000
fast: false
reactant: MODEL1310110042#
reversible: true

metaR GALASE1ly
is version of: http://identifiers.org/ec-code/3.4.16.5
is version of: http://identifiers.org/ec-code/3.2.1.18
is described by: ECO:0000000
product: MODEL1310110042#
kinetic law: MODEL1310110042#
is version of: http://identifiers.org/ec-code/3.1.6.4
fast: false
modifier: MODEL1310110042#
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) or (5476.1) and (2720.1) SUBSYSTEM: N-glycan degradation EC Number: 3.2.1.23 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD
is version of: http://identifiers.org/ec-code/3.2.1.23
type: Reaction
is: SBO:0000176
reactant: MODEL1310110042#
name: beta-galactosidase, lysosomal
reversible: false

metaR BILGLCURtr
reversible: true
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: NOTES:unknown mechanism, however glucuronidated metabolites need to get out of the cell NJ
is described by: ECO:0000000
kinetic law: MODEL1310110042#
type: Reaction
fast: false
product: MODEL1310110042#
name: glucuronidated compound transport
reactant: MODEL1310110042#

http://identifiers.org/biomodels.db/MODEL1310110042#_befd8dd9_b561_4e2f_bb0b_9732306e5b2f
boundary condition: true
initial concentration: NaN
name: ACADL
is: P28330
initial amount: NaN
is encoded by: hsa:33
has only substance units: false
type: Species
is: SBO:0000252
constant: false

metaR r0797
notes: GENE_ASSOCIATION: (220.1) or (218.1) or (221.1) or (222.1) or (U37519.1) SUBSYSTEM: Bile acid synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:12810727,PMID:6884990 NOTES:
fast: false
type: Reaction
is described by: ECO:0000000
product: MODEL1310110042#
modifier: MODEL1310110042#
kinetic law: MODEL1310110042#
is: SBO:0000176
name: glycine N-choloyltransferase EC:2.3.1.65
reversible: true
reactant: MODEL1310110042#
is version of: http://identifiers.org/ec-code/1.2.1.5

metaM dutp m
initial concentration: 1.0
initial amount: NaN
is: CHEBI:17625
constant: false
name: dUTP
type: Species
boundary condition: false
notes: FORMULA: C9H11N2O14P3 CHARGE: -4 INCHI: InChI=1S/C9H15N2O14P3/c12-5-3-8(11-2-1-7(13)10-9(11)14)23-6(5)4-22-27(18,19)25-28(20,21)24-26(15,16)17/h1-2,5-6,8,12H,3-4H2,(H,18,19)(H,20,21)(H,10,13,14)(H2,15,16,17)/t5-,6+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00369 EHMN_ABBREVIATION: C00460
is: HMDB01191
has only substance units: false
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110042#_8facf6b0_1cf6_4b6c_8318_8b77fab5fe1b
initial amount: NaN
boundary condition: true
is encoded by: hsa:146712
is: Q67FW5
is: SBO:0000252
type: Species
name: B3GNTL1
initial concentration: NaN
has only substance units: false
constant: false

http://identifiers.org/biomodels.db/MODEL1310110042#_fb7959af_1a0f_4bea_9a3f_0e6bc04b67a7
is: SBO:0000252
constant: false
is encoded by: hsa:6470
name: SHMT1
boundary condition: true
type: Species
has only substance units: false
initial amount: NaN
initial concentration: NaN

metaM dgchol e
initial concentration: 1.0
notes: FORMULA: C26H43NO5 CHARGE: 0 INCHI: InChI=1S/C26H43NO5/c1-15(4-7-22(30)27-14-23(31)32)18-5-6-19-24-20(9-11-26(18,19)3)25(2)10-8-17(28)12-16(25)13-21(24)29/h15-21,24,28-29H,4-14H2,1-3H3,(H,27,30)(H,31,32)/p-1/t15-,16+,17-,18-,19+,20+,21-,24+,25+,26-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01472
type: Species
is: CHEBI:36252
name: glycochenodeoxycholate
boundary condition: false
initial amount: NaN
constant: false
is: SBO:0000247
is: HMDB00637
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110042#_5d76b36b_9156_42a8_a8d8_0a95be41a067
is: SBO:0000252
is encoded by: hsa:11282
initial concentration: NaN
type: Species
constant: false
initial amount: NaN
boundary condition: true
name: MGAT4B
is: Q9UQ53
has only substance units: false

metaR r0456
is version of: http://identifiers.org/ec-code/2.7.1.32
reversible: false
is version of: http://identifiers.org/ec-code/2.3.1.21
is: SBO:0000176
reactant: MODEL1310110042#
modifier: MODEL1310110042#
fast: false
product: MODEL1310110042#
notes: GENE_ASSOCIATION: (AA614647.1) or (1120.1) or (1374.1) or (1375.1) or (126129.1) or (1376.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.1.113 Confidence Level: 0 AUTHORS: PMID:15748706 NOTES:
is described by: ECO:0000000
name: ATP:deoxyguanosine 5-phosphotransferase Purine metabolism EC:2.7.1.113
kinetic law: MODEL1310110042#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110042#_e8604da6_e1f3_4445_984a_ae482617739c
is: SBO:0000252
constant: false
is: P41222
type: Species
initial amount: NaN
initial concentration: NaN
name: PTGDS
has only substance units: false
boundary condition: true
is encoded by: hsa:5730

http://identifiers.org/biomodels.db/MODEL1310110042#_daa92d17_8ada_4985_b618_d8122d3c76c2
is encoded by: hsa:83715
is: B1AK53
constant: false
name: ESPN
boundary condition: true
initial concentration: NaN
type: Species
is: SBO:0000252
has only substance units: false
initial amount: NaN

metaM omhpal r
is: SBO:0000247
has only substance units: false
is: HMDB06294
constant: false
initial concentration: 1.0
initial amount: NaN
type: Species
name: w-hydroxypalmiticacid
notes: FORMULA: C16H30O3 CHARGE: -1
boundary condition: false

metaM ksi pre19 g
name: keratan sulfate I biosynthesis, precursor 19
initial concentration: 1.0
is: HMDB00175
initial amount: NaN
is: CHEBI:58053
has only substance units: false
type: Species
notes: FORMULA: C171H275N12O137S5X CHARGE: -6
boundary condition: false
is: C00130
is: SBO:0000247
constant: false

metaM 56dura c
is: HMDB00076
is: CHEBI:15901
name: 5,6-dihydrouracil
initial concentration: 1.0
has only substance units: false
is: SBO:0000247
initial amount: NaN
notes: FORMULA: C4H6N2O2 CHARGE: 0 INCHI: InChI=1S/C4H6N2O2/c7-3-1-2-5-4(8)6-3/h1-2H2,(H2,5,6,7,8) HEPATONET_1.0_ABBREVIATION: HC00348 EHMN_ABBREVIATION: C00429
boundary condition: false
constant: false
type: Species

metaR DECDICRNe
kinetic law: MODEL1310110042#
product: MODEL1310110042#
reactant: MODEL1310110042#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: trnasport of decadienoyl carnitine into the extra cellular space
type: Reaction

metaR r2377
is described by: ECO:0000000
reactant: MODEL1310110042#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:16919238,PMID:17173541,PMID:18406340,PMID:8132483 NOTES:
fast: false
kinetic law: MODEL1310110042#
product: MODEL1310110042#
reversible: true
is: SBO:0000185
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
type: Reaction

metaM ksi pre33 g
notes: FORMULA: C233H372N16O197S10X CHARGE: -11
initial concentration: 1.0
name: keratan sulfate I biosynthesis, precursor 33
is: HMDB00175
is: SBO:0000247
type: Species
is: CHEBI:58053
initial amount: NaN
is: C00130
has only substance units: false
boundary condition: false
constant: false

metaR DOLMANP Uter
name: dolichol-phosphate mannose flippase (uterus)
is described by: ECO:0000000
kinetic law: MODEL1310110042#
notes: GENE_ASSOCIATION: SUBSYSTEM: N-glycan synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:12137737 NOTES:
reactant: MODEL1310110042#
is: SBO:0000185
product: MODEL1310110042#
reversible: false
type: Reaction
fast: false

metaM datp c
has only substance units: false
is: C00131
notes: FORMULA: C10H12N5O12P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00129 EHMN_ABBREVIATION: C00131
constant: false
is: HMDB01532
is: SBO:0000247
initial concentration: 1.0
initial amount: NaN
is: CHEBI:61404
boundary condition: false
type: Species
name: dATP

http://identifiers.org/biomodels.db/MODEL1310110042#_9d4e7193_541a_4b94_83f1_edd9aec5a8b8
boundary condition: true
constant: false
is: F8WDN9
has only substance units: false
is: SBO:0000252
name: PPA2
type: Species
initial amount: NaN
is encoded by: hsa:27068
initial concentration: NaN

metaM oagt3 hs c
is: SBO:0000247
is: C00329
notes: FORMULA: C65H106N4O37FULLRCO CHARGE: -3
type: Species
name: 9-O-Acetylated GT3
initial concentration: 1.0
boundary condition: false
has only substance units: false
is: CHEBI:17315
constant: false
is: HMDB01514
initial amount: NaN

metaR EX ptrc LPAREN e RPAREN
kinetic law: MODEL1310110042#
reactant: MODEL1310110042#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of 1,4-butanediammonium
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110042#_92b7d311_27fd_47f6_9181_fd3c200eb141
type: Species
is encoded by: hsa:83733
is: Q9H1K4
constant: false
initial amount: NaN
boundary condition: true
is: SBO:0000252
name: SLC25A18
initial concentration: NaN
has only substance units: false

metaM ksi deg12 l
has only substance units: false
initial amount: NaN
name: keratan sulfate I, degradation product 12
initial concentration: 1.0
is: SBO:0000247
boundary condition: false
is: CHEBI:12936
notes: FORMULA: C174H279N12O153S9 CHARGE: -9
constant: false
type: Species
is: HMDB00143

metaM hista e
is: CHEBI:58432
initial concentration: 1.0
is: SBO:0000247
type: Species
is: HMDB00870
constant: false
notes: FORMULA: C5H10N3 CHARGE: 1 INCHI: InChI=1S/C5H9N3/c6-2-1-5-3-7-4-8-5/h3-4H,1-2,6H2,(H,7,8)/p+1 HEPATONET_1.0_ABBREVIATION: HC00323 EHMN_ABBREVIATION: C00388
name: histamium
initial amount: NaN
has only substance units: false
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110042#_109e06a7_805c_4b8e_b208_08b47fd0e959
has only substance units: false
is encoded by: hsa:2686
constant: false
name: GGT7
boundary condition: true
is: A0PJJ9
type: Species
initial concentration: NaN
is: SBO:0000252
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110042#_4ec31f23_2b99_473f_aebe_d0bd42da20e2
is: SBO:0000252
has only substance units: false
name: PGM3
boundary condition: true
constant: false
is: B4DX94
is encoded by: hsa:5238
type: Species
initial concentration: NaN
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110042#_69ff82ec_7f71_4df2_a145_a598dd3789fc
name: PDE9A
constant: false
initial concentration: NaN
is: SBO:0000252
type: Species
initial amount: NaN
boundary condition: true
has only substance units: false
is encoded by: hsa:5152

http://identifiers.org/biomodels.db/MODEL1310110042#_9fb2d2b6_5564_4201_baff_b28fc225328e
name: CHAT
is: SBO:0000252
is encoded by: hsa:1103
initial amount: NaN
is: P28329
boundary condition: true
type: Species
has only substance units: false
constant: false
initial concentration: NaN

metaR 3AIBtm
is: SBO:0000185
kinetic law: MODEL1310110042#
type: Reaction
modifier: MODEL1310110042#
reversible: false
reactant: MODEL1310110042#
name: 3-amino-isobutyrate transport, mitochondrial
is version of: http://identifiers.org/ec-code/2.6.1.19
fast: false
is described by: ECO:0000000
product: MODEL1310110042#
notes: GENE_ASSOCIATION: (18.1) or (18.2) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: NOTES:

metaM m5mpdol U r
has only substance units: false
is: SBO:0000247
type: Species
initial concentration: 1.0
initial amount: NaN
is: CHEBI:37634
constant: false
notes: FORMULA: C1545H2540N20O470P20 CHARGE: -20
name: (alpha-D-Mannosyl)5-beta-D-mannosyl-diacetylchitobiosyldiphosphodolichol, human uterine homolog
boundary condition: false

metaR r2376
reactant: MODEL1310110042#
type: Reaction
is: SBO:0000185
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
product: MODEL1310110042#
kinetic law: MODEL1310110042#
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:16919238,PMID:17173541,PMID:18406340,PMID:8132483 NOTES:
is described by: ECO:0000000
fast: false

http://identifiers.org/biomodels.db/MODEL1310110042#_f98cc882_4095_411d_b78e_ddde0296d2b8
boundary condition: true
is: Q1LZ56
name: SLC36A1
constant: false
is: SBO:0000252
is encoded by: hsa:206358
has only substance units: false
initial amount: NaN
type: Species
initial concentration: NaN

metaM dcsptn1coa x
boundary condition: false
name: docosa-4,7,10,13,16-pentaenoyl coenzyme A
notes: FORMULA: C43H64N7O17P3S CHARGE: -4 INCHI: InChI=1/C43H68N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-34(52)71-27-26-45-33(51)24-25-46-41(55)38(54)43(2,3)29-64-70(61,62)67-69(59,60)63-28-32-37(66-68(56,57)58)36(53)42(65-32)50-31-49-35-39(44)47-30-48-40(35)50/h8-9,11-12,14-15,17-18,20-21,30-32,36-38,42,53-54H,4-7,10,13,16,19,22-29H2,1-3H3,(H,45,51)(H,46,55)(H,59,60)(H,61,62)(H2,44,47,48)(H2,56,57,58)/b9-8-,12-11-,15-14-,18-17-,21-20-/t32-,36-,37?,38+,42-/m1/s1
is: C16173
is: SBO:0000247
initial concentration: 1.0
type: Species
has only substance units: false
initial amount: NaN
constant: false
is: http://identifiers.org/pubchem.compound/47205483
is: HMDB06513

metaR RE0935E
product: MODEL1310110042#
fast: false
notes: GENE_ASSOCIATION: (276.1) or (277.1) or (278.1) or (279.1) or (276.1) or (277.1) or (278.1) or (279.1) or (280.1) or (84569.1) SUBSYSTEM: Starch and sucrose metabolism EC Number: 3.2.1.1 Confidence Level: 0 AUTHORS: PMID:385176,PMID:8528071,PMID:890964 NOTES:
reversible: true
name: RE0935
type: Reaction
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/3.2.1.17
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.2.1.1
reactant: MODEL1310110042#
modifier: MODEL1310110042#
kinetic law: MODEL1310110042#

http://identifiers.org/biomodels.db/MODEL1310110042#_948b2dc5_4491_4e24_969a_977a53da0e6b
initial concentration: NaN
is: P33121
is encoded by: hsa:2180
is: SBO:0000252
initial amount: NaN
type: Species
has only substance units: false
boundary condition: true
constant: false
name: ACSL1

metaM CE5118 m
name: trans-2-cis,cis-4,8-tetradecatrienoyl-CoA
has only substance units: false
initial concentration: 1.0
boundary condition: false
type: Species
initial amount: NaN
notes: FORMULA: C35H52N7O17P3S CHARGE: -4 INCHI: InChI=1/C35H56N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-26(44)63-19-18-37-25(43)16-17-38-33(47)30(46)35(2,3)21-56-62(53,54)59-61(51,52)55-20-24-29(58-60(48,49)50)28(45)34(57-24)42-23-41-27-31(36)39-22-40-32(27)42/h8-9,12-15,22-24,28-30,34,45-46H,4-7,10-11,16-21H2,1-3H3,(H,37,43)(H,38,47)(H,51,52)(H,53,54)(H2,36,39,40)(H2,48,49,50)/p-4/b9-8-,13-12-,15-14+/t24-,28+,29+,30u,34-/m0/s1 EHMN_ABBREVIATION: CE5118
is: SBO:0000247
is: CHEBI:57923
constant: false

metaR GLYBt4 2 r
notes: GENE_ASSOCIATION: (6539.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12719981 NOTES:SAB
kinetic law: MODEL1310110042#
name: Betaine transport (sodium symport) (2:1)
is: SBO:0000185
modifier: MODEL1310110042#
reactant: MODEL1310110042#
fast: false
type: Reaction
reversible: true
product: MODEL1310110042#
is described by: ECO:0000269

http://identifiers.org/biomodels.db/MODEL1310110042#_b7de5af8_813f_4a28_849c_9029f4df2e88
initial concentration: NaN
constant: false
name: _AA614647_1_c
has only substance units: false
boundary condition: true
is: SBO:0000252
type: Species
initial amount: NaN
is encoded by: hsa:AA614647

metaR DM pmtcoa LPAREN r RPAREN
kinetic law: MODEL1310110042#
reactant: MODEL1310110042#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 0 AUTHORS: PMID: 17173541 NOTES:added during gap-filling, no evidence for such a reaction. only assumed.
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: demand reaction for pmtcoa
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110042#_bb722771_e0f0_42d4_94fc_e8a8d492638c
name: ASAH1
has only substance units: false
is: SBO:0000252
initial concentration: NaN
is: Q96AS2
is encoded by: hsa:427
type: Species
constant: false
initial amount: NaN
boundary condition: true

metaR r0853
is described by: ECO:0000000
reversible: false
kinetic law: MODEL1310110042#
name: Facilitated diffusion
reactant: MODEL1310110042#
product: MODEL1310110042#
type: Reaction
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Purine catabolism EC Number: Confidence Level: 0 AUTHORS: PMID:8132483 NOTES:
fast: false

metaR AMACR2p
type: Reaction
is version of: http://identifiers.org/ec-code/5.1.99.4
kinetic law: MODEL1310110042#
is described by: ECO:0000304
reactant: MODEL1310110042#
is: SBO:0000176
reversible: false
product: MODEL1310110042#
notes: GENE_ASSOCIATION: (23600.1) or (23600.2) SUBSYSTEM: Bile acid synthesis EC Number: 5.1.99.4 Confidence Level: 2 AUTHORS: NOTES:should be analogous to AMACRp as per KEGG - in this case: reductase not a racemase NJ
name: alpha-methylacyl-CoA racemase (reductase)
fast: false
modifier: MODEL1310110042#

metaR r2375
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:16919238,PMID:17173541,PMID:18406340,PMID:8132483 NOTES:
reversible: true
is described by: ECO:0000000
product: MODEL1310110042#
type: Reaction
kinetic law: MODEL1310110042#
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
fast: false
reactant: MODEL1310110042#

metaM m1mpdol L c
name: alpha-D-mannosyl-beta-D-mannosyl-diacylchitobiosyldiphosphodolichol, human liver homolog
type: Species
is: CHEBI:28067
is: SBO:0000247
initial concentration: 1.0
boundary condition: false
constant: false
has only substance units: false
notes: FORMULA: C1360H2228N20O270P20 CHARGE: -20 INCHI: InChI=1S/C53H92N2O27P2/c1-27(2)13-9-14-28(3)15-10-16-29(4)17-11-18-30(5)19-12-20-31(6)21-22-73-83(69,70)82-84(71,72)81-51-39(55-33(8)61)43(65)47(37(26-59)77-51)78-50-38(54-32(7)60)42(64)48(36(25-58)76-50)79-53-46(68)49(41(63)35(24-57)75-53)80-52-45(67)44(66)40(62)34(23-56)74-52/h13,15,17,19,31,34-53,56-59,62-68H,9-12,14,16,18,20-26H2,1-8H3,(H,54,60)(H,55,61)(H,69,70)(H,71,72)/b28-15+,29-17+,30-19+/t31?,34-,35-,36-,37-,38-,39-,40-,41-,42-,43-,44+,45+,46+,47-,48-,49+,50+,51-,52-,53+/m1/s1
initial amount: NaN

metaR AGTim
reactant: MODEL1310110042#
is version of: http://identifiers.org/ec-code/2.6.1.44
modifier: MODEL1310110042#
name: alanine-glyoxylate transaminase (irreversible), mitochondrial
is: SBO:0000176
reversible: false
product: MODEL1310110042#
is described by: ECO:0000269
type: Reaction
fast: false
kinetic law: MODEL1310110042#
notes: GENE_ASSOCIATION: (64902.1) or (64850.1) SUBSYSTEM: Alanine and aspartate metabolism EC Number: 2.6.1.44 Confidence Level: 4 AUTHORS: PMID:15240345,PMID:9038835,PMID:9783918 NOTES:NCD

metaM hista c
is: SBO:0000247
initial concentration: 1.0
is: CHEBI:58432
has only substance units: false
is: HMDB00870
boundary condition: false
constant: false
name: histamium
type: Species
initial amount: NaN
notes: FORMULA: C5H10N3 CHARGE: 1 INCHI: InChI=1S/C5H9N3/c6-2-1-5-3-7-4-8-5/h3-4H,1-2,6H2,(H,7,8)/p+1 HEPATONET_1.0_ABBREVIATION: HC00323 EHMN_ABBREVIATION: C00388

http://identifiers.org/biomodels.db/MODEL1310110042#_09f6d985_ce42_47c1_9380_334d8d1be32b
boundary condition: true
is: SBO:0000252
is: E9PB82
initial amount: NaN
has only substance units: false
initial concentration: NaN
constant: false
name: HSD17B4
type: Species
is encoded by: hsa:3295

metaR HMGCOASi
modifier: MODEL1310110042#
product: MODEL1310110042#
reactant: MODEL1310110042#
is: SBO:0000176
notes: GENE_ASSOCIATION: (3157.1) or (3157.2) SUBSYSTEM: Cholesterol metabolism EC Number: 4.1.3.5 Confidence Level: 4 AUTHORS: PMID:1358203 NOTES:NCD New assignment: EC-2.3.3.10 EC-4.1.3.5 (created 1961, deleted 2002). Enzyme Commission Made irreversible to match KEGG data for S. aureus
fast: false
kinetic law: MODEL1310110042#
type: Reaction
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/2.3.3.10
name: Hydroxymethylglutaryl CoA synthase (ir)
reversible: false

metaR ADK1
product: MODEL1310110042#
type: Reaction
kinetic law: MODEL1310110042#
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (122481.1) or (203.1) or (26289.1) or (26289.2) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: NOTES:
modifier: MODEL1310110042#
fast: false
reactant: MODEL1310110042#
reversible: true
is version of: http://identifiers.org/ec-code/2.7.4.3
name: adenylate kinase
is: SBO:0000176

metaR FAOXC241181x
kinetic law: MODEL1310110042#
modifier: MODEL1310110042#
is version of: http://identifiers.org/ec-code/1.1.1.35
is version of: http://identifiers.org/ec-code/1.3.3.6
product: MODEL1310110042#
fast: false
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.3.1.16
notes: GENE_ASSOCIATION: (3295.1 and 30.1 and 51.2) or (51.1 and 30.1 and 1962.1) or (51.1 and 3295.1 and 30.1) or (30.1 and 51.2 and 1962.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.74 Confidence Level: 4 AUTHORS: NOTES:peroxisomal (very long chain FA) - in peroxisome, no fad, 1ste set of beta-ox is by acyl-coa oxidase (passes electrons directly to o2 -> h2o2) c24:1 -> c18:1 - 3 rounds beta-ox 4 step FAO lumped also includes EC 1.1.1.35, 1.1.1.211, 1.3.3.6, 4.2.1.17, 4.2.1.74 NJ
is version of: http://identifiers.org/ec-code/4.2.1.107
reversible: false
type: Reaction
is described by: ECO:0000269
name: Beta oxidation of long chain fatty acid
reactant: MODEL1310110042#

metaR NACHEX27ly
type: Reaction
name: beta-N-acetylhexosaminidase, lysosomal
notes: GENE_ASSOCIATION: (3073.1 and 3074.1) or (3073.1) or (3074.1) SUBSYSTEM: Hyaluronan metabolism EC Number: 3.2.1.52 Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12562784 NOTES:NCD
is: SBO:0000176
product: MODEL1310110042#
fast: false
is version of: http://identifiers.org/ec-code/3.2.1.52
is described by: ECO:0000269
kinetic law: MODEL1310110042#
modifier: MODEL1310110042#
reactant: MODEL1310110042#
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110042#_bfc6b6cc_f14e_4103_b16f_1a63601067a9
name: PLCH2
initial concentration: NaN
is encoded by: hsa:9651
type: Species
has only substance units: false
boundary condition: true
is: SBO:0000252
constant: false
initial amount: NaN
is: O75038

metaR r2374
fast: false
is described by: ECO:0000000
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
reactant: MODEL1310110042#
type: Reaction
is: SBO:0000185
product: MODEL1310110042#
kinetic law: MODEL1310110042#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:16919238,PMID:17173541,PMID:18406340,PMID:8132483 NOTES:
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110042#_d35406ab_6d10_49bc_bd47_903c415b29af
type: Species
has only substance units: false
boundary condition: true
is encoded by: hsa:10632
initial concentration: NaN
is: O75964
is: SBO:0000252
initial amount: NaN
constant: false
name: ATP5L

metaM arab L e
notes: FORMULA: C5H10O5 CHARGE: 0
is: HMDB00646
has only substance units: false
is: CHEBI:30849
type: Species
boundary condition: false
name: L-arabinose
is: SBO:0000247
initial amount: NaN
initial concentration: 1.0
constant: false

metaR EX dlnlcg LPAREN e RPAREN
kinetic law: MODEL1310110042#
reactant: MODEL1310110042#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: dihomo-gamma-linolenic acid (n-6) exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110042#_b4ad8b00_a136_4a32_8c19_c8d5a7788a5b
is: SBO:0000252
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:51109
constant: false
name: RDH11
boundary condition: true
is: B4DDW0
has only substance units: false
type: Species

metaM ala B m
boundary condition: false
is: CHEBI:16958
notes: FORMULA: C3H7NO2 CHARGE: 0 INCHI: InChI=1S/C3H7NO2/c4-2-1-3(5)6/h1-2,4H2,(H,5,6) HEPATONET_1.0_ABBREVIATION: HC00100
type: Species
constant: false
has only substance units: false
is: HMDB00056
initial concentration: 1.0
is: SBO:0000247
initial amount: NaN
name: beta-alanine

metaR NDPK2
reversible: true
reactant: MODEL1310110042#
modifier: MODEL1310110042#
fast: false
is version of: http://identifiers.org/ec-code/2.7.4.6
kinetic law: MODEL1310110042#
type: Reaction
name: nucleoside-diphosphate kinase (ATP:UDP)
product: MODEL1310110042#
notes: GENE_ASSOCIATION: (4832.1) or (29922.1) or (4831.1 and 4830.1) or (10201.1) or (4831.1 and 4830.2) or (29922.2) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: NOTES:
is described by: ECO:0000269
is: SBO:0000176

metaM HC00319 c
notes: FORMULA: C3H2O4 CHARGE: -2 INCHI: InChI=1S/C3H4O4/c4-2(5)1-3(6)7/h1H2,(H,4,5)(H,6,7)
boundary condition: false
is: CHEBI:30794
name: Malonate
type: Species
has only substance units: false
initial amount: NaN
initial concentration: 1.0
is: SBO:0000247
constant: false

http://identifiers.org/biomodels.db/MODEL1310110042#_50d133f9_f0c1_4dc2_af17_956216badb59
has only substance units: false
constant: false
boundary condition: true
initial amount: NaN
is encoded by: hsa:2713
is: SBO:0000252
name: GK3P
initial concentration: NaN
type: Species

metaM pentcoa m
is: C00888
is: HMDB13037
boundary condition: false
initial concentration: 1.0
has only substance units: false
name: pentanoylcoa
initial amount: NaN
notes: FORMULA: C26H40N7O17P3S CHARGE: -4
is: SBO:0000247
type: Species
constant: false

http://identifiers.org/biomodels.db/MODEL1310110042#_d0841a44_af50_4036_86dd_9249dd94fa0d
is: SBO:0000252
boundary condition: true
initial concentration: NaN
constant: false
is: B7Z7I0
has only substance units: false
initial amount: NaN
name: TKTL1
is encoded by: hsa:8277
type: Species

metaR RE1897C
notes: GENE_ASSOCIATION: SUBSYSTEM: Urea cycle EC Number: 2.5.1.46 Confidence Level: 0 AUTHORS: PMID:9188485 NOTES:
name: RE1897
is described by: ECO:0000000
reversible: true
kinetic law: MODEL1310110042#
product: MODEL1310110042#
type: Reaction
fast: false
reactant: MODEL1310110042#
is: SBO:0000176

metaR DHCR242r
modifier: MODEL1310110042#
reactant: MODEL1310110042#
notes: GENE_ASSOCIATION: (1718.1) SUBSYSTEM: Cholesterol metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:17984220,PMID:19520779,PMID:19520780 NOTES:lanosterol -> cholesterol pathway FAD known to be cofactor, other details missing NJ
product: MODEL1310110042#
is version of: http://identifiers.org/ec-code/1.3.1.72
reversible: false
type: Reaction
is: SBO:0000176
fast: false
kinetic law: MODEL1310110042#
is described by: ECO:0000134
name: 24-dehydrocholesterol reductase [Precursor]

metaM oagt3 hs g
is: CHEBI:17315
notes: FORMULA: C65H106N4O37FULLRCO CHARGE: -3
name: 9-O-Acetylated GT3
is: C00329
is: SBO:0000247
boundary condition: false
type: Species
has only substance units: false
initial amount: NaN
constant: false
is: HMDB01514
initial concentration: 1.0

metaM ocdececrn m
is: HMDB06351
is: SBO:0000247
has only substance units: false
boundary condition: false
name: 11-octadecenoyl carnitine
initial amount: NaN
initial concentration: 1.0
notes: FORMULA: C25H47NO4 CHARGE: 0
constant: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110042#_9b5426c9_a0ac_4300_a822_7eeecbb561f5
initial amount: NaN
is: SBO:0000252
is: Q59EA4
has only substance units: false
initial concentration: NaN
constant: false
is encoded by: hsa:5337
name: PLD1
type: Species
boundary condition: true

metaR GLCt1r
kinetic law: MODEL1310110042#
modifier: MODEL1310110042#
reactant: MODEL1310110042#
fast: false
is described by: ECO:0000269
product: MODEL1310110042#
is: SBO:0000185
reversible: true
type: Reaction
name: glucose transport (uniport)
notes: GENE_ASSOCIATION: (66035.1) or (6517.1) or (56606.1) or (154091.1) or (6513.1) or (11182.1) or (29988.1) or (6514.1) or (155184.1) or (56606.2) or (144195.1) or (6515.1) or (81031.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10421229,PMID:10821868,PMID:10860667,PMID:10860996,PMID:10970791,PMID:11247674,PMID:11583593,PMID:11592815,PMID:11780753,PMID:11832379,PMID:11882499,PMID:12135767,PMID:12483288,PMID:12504846,PMID:12750891,PMID:12914765,PMID:14739288,PMID:15033637,PMID:1701966,PMID:2182619,PMID:2656669,PMID:3103217,PMID:3170580,PMID:3399500,PMID:3839598,PMID:7926364,PMID:8504756,PMID:9230074,PMID:9770484 NOTES:

metaR r2373
reversible: true
is: SBO:0000185
is described by: ECO:0000000
type: Reaction
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
kinetic law: MODEL1310110042#
fast: false
reactant: MODEL1310110042#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:16919238,PMID:17173541,PMID:18406340,PMID:8132483 NOTES:
product: MODEL1310110042#

metaM dttp m
notes: FORMULA: C10H13N2O14P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00368 EHMN_ABBREVIATION: C00459
initial amount: NaN
name: dTTP
boundary condition: false
is: SBO:0000247
is: CHEBI:37568
is: C00459
initial concentration: 1.0
constant: false
is: HMDB01342
type: Species
has only substance units: false

metaM sph1p e
type: Species
name: (2S,3R)-2-azaniumyl-3-hydroxyoctadecyl phosphate
boundary condition: false
constant: false
initial concentration: 1.0
has only substance units: false
is: SBO:0000247
notes: FORMULA: C18H39NO5P CHARGE: -1 INCHI: InChI=1S/C18H40NO5P/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-18(20)17(19)16-24-25(21,22)23/h17-18,20H,2-16,19H2,1H3,(H2,21,22,23)/p-1/t17-,18+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00675 EHMN_ABBREVIATION: C01120
initial amount: NaN
is: CHEBI:57939
is: HMDB01383

http://identifiers.org/biomodels.db/MODEL1310110042#_2d498125_3e19_4357_a225_2659a00d4b28
is: SBO:0000252
initial amount: NaN
has only substance units: false
boundary condition: true
is: O14734
is encoded by: hsa:10005
name: ACOT8
constant: false
initial concentration: NaN
type: Species

metaM ksii core2 deg4 l
constant: false
has only substance units: false
is: HMDB00812
is: SBO:0000247
is: CHEBI:16953
name: keratan sulfate II (core 2-linked), degradation product 4
boundary condition: false
type: Species
initial amount: NaN
notes: FORMULA: C58H95N5O43SX CHARGE: -1
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110042#_34cd0339_a0dd_4b9e_a77a_495af78ceb4f
constant: false
name: NDUFA12
type: Species
is encoded by: hsa:55967
is: SBO:0000252
is: F8VQS7
initial concentration: NaN
boundary condition: true
initial amount: NaN
has only substance units: false

metaR SERGLNNaEx
fast: false
reversible: false
reactant: MODEL1310110042#
is: SBO:0000185
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (6510.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14530974 NOTES:SAB see Kanai and Hediger 2004 (2003), PMID 14530974
type: Reaction
name: L-serine/L-glutamine Na-dependent exchange (Ser-L in)
product: MODEL1310110042#
modifier: MODEL1310110042#
kinetic law: MODEL1310110042#

http://identifiers.org/biomodels.db/MODEL1310110042#_041c9bed_78fd_410f_b744_e72d5a3d2898
name: RRM2B
is: Q7LG56
initial amount: NaN
has only substance units: false
type: Species
is encoded by: hsa:50484
initial concentration: NaN
boundary condition: true
is: SBO:0000252
constant: false

metaR NDPK1
modifier: MODEL1310110042#
is described by: ECO:0000134
is version of: http://identifiers.org/ec-code/2.7.4.6
name: nucleoside-diphosphate kinase (ATP:GDP)
reactant: MODEL1310110042#
type: Reaction
kinetic law: MODEL1310110042#
fast: false
is: SBO:0000176
reversible: true
product: MODEL1310110042#
notes: GENE_ASSOCIATION: (4832.1) or (10201.1) or (4831.1 and 4830.1) or (29922.2) or (4831.1 and 4830.2) or (29922.1) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: NOTES:

metaR S6TASE23ly
is described by: ECO:0000000
fast: false
type: Reaction
is version of: http://identifiers.org/ec-code/3.1.6.14
is: SBO:0000176
name: N-acetylglucosamine-6-sulfatase, lysosomal
reactant: MODEL1310110042#
modifier: MODEL1310110042#
product: MODEL1310110042#
reversible: true
notes: GENE_ASSOCIATION: (2799.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.1.6.14 Confidence Level: 4 AUTHORS: PMID:3196333,PMID:3689314,PMID:3689315 NOTES:NCD
kinetic law: MODEL1310110042#

metaR RE3627M
is: SBO:0000176
name: RE3627
reversible: true
is version of: http://identifiers.org/ec-code/1.1.1.35
product: MODEL1310110042#
notes: GENE_ASSOCIATION: (3295.1) or (1962.1) or (3033.1) or (3028.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.1.1.35 Confidence Level: 0 AUTHORS: PMID:11356164,PMID:7775433 NOTES:
is described by: ECO:0000000
reactant: MODEL1310110042#
type: Reaction
is version of: http://identifiers.org/ec-code/4.2.1.107
kinetic law: MODEL1310110042#
modifier: MODEL1310110042#
fast: false

http://identifiers.org/biomodels.db/MODEL1310110042#_603da846_d655_4157_a39b_ff8d2e3bcf48
type: Species
has part: P07195
has part: P00338
initial amount: NaN
is encoded by: hsa:3945
is: SBO:0000297
has only substance units: false
name: LDHA:LDHB
constant: false
boundary condition: true
is encoded by: hsa:3939
initial concentration: NaN

metaR ADK3
reversible: true
type: Reaction
product: MODEL1310110042#
modifier: MODEL1310110042#
notes: GENE_ASSOCIATION: (26289.1) or (26289.2) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: PMID:9434148 NOTES:JLR
is version of: http://identifiers.org/ec-code/2.7.4.3
is described by: ECO:0000269
kinetic law: MODEL1310110042#
fast: false
name: adentylate kinase (GTP)
reactant: MODEL1310110042#
is: SBO:0000176

metaR r0450
kinetic law: MODEL1310110042#
is version of: http://identifiers.org/ec-code/4.2.1.3
reversible: true
type: Reaction
is: SBO:0000176
notes: GENE_ASSOCIATION: (AA278423.1) or (48.1) or (50.1) SUBSYSTEM: Lysine metabolism EC Number: 2.6.1.39 Confidence Level: 0 AUTHORS: PMID:8087205 NOTES:
product: MODEL1310110042#
name: L-2-Aminoadipate:2-oxoglutarate aminotransferase Lysine biosynthesis / Lysine degradation EC:2.6.1.39
reactant: MODEL1310110042#
fast: false
is described by: ECO:0000000
modifier: MODEL1310110042#

http://identifiers.org/biomodels.db/MODEL1310110042#_b7954fe2_0b60_4fd2_a1ab_24b736254697
boundary condition: true
is: SBO:0000252
constant: false
initial concentration: NaN
initial amount: NaN
type: Species
is encoded by: hsa:6568
is: Q14916
has only substance units: false
name: SLC17A1

metaR PE HSter
type: Reaction
product: MODEL1310110042#
kinetic law: MODEL1310110042#
fast: false
reactant: MODEL1310110042#
is described by: ECO:0000000
name: phosphatidylethanolamine scramblase
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: PMID:10856717,PMID:15311932 NOTES:
reversible: true
is: SBO:0000185

metaM pail5p hs c
name: 1-phosphatidyl-1D-myo-inositol 5-phosphate(3-)
has only substance units: false
type: Species
initial concentration: 1.0
boundary condition: false
initial amount: NaN
is: CHEBI:57795
notes: FORMULA: C9H15O12P2FULLRCO2FULLR2CO2 CHARGE: -3
constant: false
is: SBO:0000247

metaR PSt3
type: Reaction
reversible: true
is described by: ECO:0000269
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: 2.7.8.8 Confidence Level: 2 AUTHORS: NOTES:
fast: false
product: MODEL1310110042#
kinetic law: MODEL1310110042#
name: phosphatidylserine transport
reactant: MODEL1310110042#

metaM acetol c
boundary condition: false
has only substance units: false
is: SBO:0000247
initial concentration: 1.0
notes: FORMULA: C3H6O2 CHARGE: 0 INCHI: InChI=1S/C3H6O2/c1-3(5)2-4/h4H,2H2,1H3
type: Species
is: HMDB06961
constant: false
initial amount: NaN
is: CHEBI:27957
name: hydroxyacetone

metaR GGH 5THFe
is version of: http://identifiers.org/ec-code/3.4.19.9
product: MODEL1310110042#
reversible: false
notes: GENE_ASSOCIATION: (8836.1) SUBSYSTEM: Folate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:11375437,PMID:2867095,PMID:9614206 NOTES:REMOVES EITHER ONE OR TWO GLUTAMYL RESIDUES WITH A REACTION (WILL ONLY REPRESENT 1) - last step from 5-glutamyl to monoglutamyl is in one step IT
modifier: MODEL1310110042#
is described by: ECO:0000000
name: Gamma-glutamyl hydrolase (5THF), extracellular
type: Reaction
reactant: MODEL1310110042#
kinetic law: MODEL1310110042#
fast: false
is: SBO:0000176

metaR r2372
is described by: ECO:0000000
product: MODEL1310110042#
kinetic law: MODEL1310110042#
reversible: true
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172 NOTES:
is: SBO:0000185
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
fast: false
reactant: MODEL1310110042#

metaM dttp n
constant: false
name: dTTP
boundary condition: false
is: CHEBI:37568
is: C00459
type: Species
initial concentration: 1.0
has only substance units: false
notes: FORMULA: C10H13N2O14P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00368 EHMN_ABBREVIATION: C00459
is: HMDB01342
initial amount: NaN
is: SBO:0000247

metaR HSD3A2r
name: 3 alpha-hydroxysteroid dehydrogenase (type 3)
reversible: true
modifier: MODEL1310110042#
is version of: http://identifiers.org/ec-code/1.1.1.225
notes: GENE_ASSOCIATION: (1109.1) SUBSYSTEM: Steroid metabolism EC Number: 1.1.1.225 Confidence Level: 0 AUTHORS: PMID:14643063,PMID:7650035 NOTES:Microsomal rxn see PMID: 14643063 substrate specificity still not clear (nad vs nadp) NJ
product: MODEL1310110042#
type: Reaction
reactant: MODEL1310110042#
is: SBO:0000176
kinetic law: MODEL1310110042#
fast: false
is described by: ECO:0000000

metaR EX hdca LPAREN e RPAREN
kinetic law: MODEL1310110042#
reactant: MODEL1310110042#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Hexadecanoate (n-C16:0) exchange
type: Reaction

metaR CYSTA
reactant: MODEL1310110042#
is described by: ECO:0000304
fast: false
kinetic law: MODEL1310110042#
name: cysteine transaminase
is version of: http://identifiers.org/ec-code/2.6.1.1
notes: GENE_ASSOCIATION: (2805.1) SUBSYSTEM: Methionine and cysteine metabolism EC Number: 2.6.1.3 Confidence Level: 2 AUTHORS: PMID:15189131,PMID:7113743 NOTES:MM
reversible: true
type: Reaction
is: SBO:0000176
product: MODEL1310110042#
modifier: MODEL1310110042#

metaR FAEL183
product: MODEL1310110042#
type: Reaction
is described by: ECO:0000000
kinetic law: MODEL1310110042#
name: fatty-acyl-CoA elongation (n-C18:3CoA)
reversible: false
notes: GENE_ASSOCIATION: (6785.1) SUBSYSTEM: Fatty acid synthesis EC Number: 2.3.1.86 Confidence Level: 4 AUTHORS: PMID:11138005,PMID:15189125 NOTES:fatty acid elongation step NJ
reactant: MODEL1310110042#
fast: false
modifier: MODEL1310110042#
is: SBO:0000176

metaM ksii core2 deg2 l
is: HMDB00143
has only substance units: false
constant: false
is: CHEBI:12936
notes: FORMULA: C70H114N5O56S2X CHARGE: -2
initial concentration: 1.0
initial amount: NaN
is: SBO:0000247
name: keratan sulfate II (core 2-linked), degradation product 2
boundary condition: false
type: Species

metaR FAOXC10C8m
kinetic law: MODEL1310110042#
product: MODEL1310110042#
reactant: MODEL1310110042#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C10-->C8)m
type: Reaction

metaM dutp c
has only substance units: false
is: C00460
initial amount: NaN
initial concentration: 1.0
is: CHEBI:17625
notes: FORMULA: C9H11N2O14P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00369 EHMN_ABBREVIATION: C00460
boundary condition: false
name: dUTP
constant: false
is: SBO:0000247
type: Species
is: HMDB01191

metaR ENGASE3ly
fast: false
product: MODEL1310110042#
is described by: ECO:0000000
is: SBO:0000176
reactant: MODEL1310110042#
kinetic law: MODEL1310110042#
notes: GENE_ASSOCIATION: SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.96 Confidence Level: 0 AUTHORS: NOTES:NCD
reversible: false
name: endo-beta-N-acetylglucosaminidase, lysosomal
type: Reaction

metaR NDPK10
reversible: true
modifier: MODEL1310110042#
reactant: MODEL1310110042#
name: nucleoside-diphosphate kinase (ATP:dIDP)
is described by: ECO:0000134
notes: GENE_ASSOCIATION: (4832.1) or (4831.1 and 4830.1) or (10201.1) or (29922.2) or (29922.1) or (4831.1 and 4830.2) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.6 Confidence Level: 4 AUTHORS: PMID:7050910 NOTES:Many nucleoside diphosphates (eight described) can act as acceptors. While many ribo- and deoxyribonucleoside triphosphates can act as donors, only ATP is chosen as a donor to minimize the number of total reactions.
is: SBO:0000176
fast: false
kinetic law: MODEL1310110042#
product: MODEL1310110042#
is version of: http://identifiers.org/ec-code/2.7.4.6
type: Reaction

metaR RE3242R
name: RE3242
type: Reaction
reversible: true
notes: GENE_ASSOCIATION: (64834.1) SUBSYSTEM: Fatty acid synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:10970790 NOTES:
kinetic law: MODEL1310110042#
fast: false
modifier: MODEL1310110042#
is: SBO:0000176
is described by: ECO:0000000
product: MODEL1310110042#
reactant: MODEL1310110042#

http://identifiers.org/biomodels.db/MODEL1310110042#_6c99c648_9e6d_498b_a31c_155c3386f1f5
is encoded by: hsa:4830
boundary condition: true
constant: false
type: Species
is: SBO:0000252
has only substance units: false
initial concentration: NaN
initial amount: NaN
name: NME1
is: P15531

metaM 7thf e
has only substance units: false
notes: FORMULA: C49H57N13O24 CHARGE: -8
name: heptaglutamyl folate (THF)
is: HMDB06559
constant: false
initial concentration: 1.0
is: SBO:0000247
boundary condition: false
initial amount: NaN
type: Species

metaM oagt3 hs e
is: CHEBI:18421
is: HMDB02168
type: Species
is: SBO:0000247
notes: FORMULA: C65H106N4O37FULLRCO CHARGE: -3
name: 9-O-Acetylated GT3
constant: false
initial amount: NaN
has only substance units: false
initial concentration: 1.0
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110042#_dc150455_3b7e_49bb_ace6_6e797eedf26a
is: SBO:0000252
has only substance units: false
boundary condition: true
name: DGKD
constant: false
type: Species
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:8527

metaR r2371
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172 NOTES:
is: SBO:0000185
is described by: ECO:0000000
fast: false
reversible: true
type: Reaction
reactant: MODEL1310110042#
kinetic law: MODEL1310110042#
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
product: MODEL1310110042#

metaR LAPCOAl
product: MODEL1310110042#
kinetic law: MODEL1310110042#
type: Reaction
notes: GENE_ASSOCIATION: (53.1) SUBSYSTEM: CoA catabolism EC Number: 3.1.3.2 Confidence Level: 2 AUTHORS: PMID:11923312,PMID:11994049 NOTES:IT. human enzymes overexpressed on E.coli, Pig Liver
reversible: false
modifier: MODEL1310110042#
is described by: ECO:0000304
is: SBO:0000176
name: lysosomal acid phosphorylase (CoA)
reactant: MODEL1310110042#
is version of: http://identifiers.org/ec-code/3.1.3.2
fast: false

metaR EX 7dhf LPAREN e RPAREN
kinetic law: MODEL1310110042#
reactant: MODEL1310110042#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: heptaglutamyl folate (DHF) exchange
type: Reaction

metaR FAOXC143C123m
kinetic law: MODEL1310110042#
product: MODEL1310110042#
reactant: MODEL1310110042#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C14:3-->C12:3)m
type: Reaction

metaM mgacpail hs r
type: Species
has only substance units: false
is: CHEBI:7896
name: mannosyl-glucosaminyl-acylphosphatidylinositiol (H2)
boundary condition: false
initial amount: NaN
notes: FORMULA: C37H68NO19PFULLRCO2FULLR2CO2 CHARGE: 0
constant: false
is: HMDB00220
is: SBO:0000247
initial concentration: 1.0
is: C00249

metaR HISD
kinetic law: MODEL1310110042#
modifier: MODEL1310110042#
reversible: false
is: SBO:0000176
notes: GENE_ASSOCIATION: (3034.1) SUBSYSTEM: Histidine metabolism EC Number: 4.3.1.3 Confidence Level: 4 AUTHORS: PMID:8530107 NOTES:
type: Reaction
is described by: ECO:0000269
product: MODEL1310110042#
fast: false
name: histidase
reactant: MODEL1310110042#
is version of: http://identifiers.org/ec-code/4.3.1.3

metaR IZPN
reactant: MODEL1310110042#
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Histidine metabolism EC Number: Confidence Level: 4 AUTHORS: NOTES:
product: MODEL1310110042#
is described by: ECO:0000000
name: Imidazolonepropionase
reversible: false
fast: false
kinetic law: MODEL1310110042#
type: Reaction

metaR r0339
name: ATP:(R)-glycerate 3-phosphotransferase Glycine, serine and threonine metabolism EC:2.7.1.31
modifier: MODEL1310110042#
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/2.3.1.65
reversible: false
is version of: http://identifiers.org/ec-code/3.1.2.2
type: Reaction
product: MODEL1310110042#
is version of: http://identifiers.org/ec-code/3.1.2.22
notes: GENE_ASSOCIATION: (10965.1) or (122970.1) or (11332.1) or (570.1) or (80864.1) or (83715.1) or (5538.1) or (9374.1) or (R33828.1) SUBSYSTEM: Unassigned EC Number: 2.7.1.31 Confidence Level: 0 AUTHORS: PMID:16753811,PMID:216417,PMID:2537226,PMID:6252205 NOTES:
reactant: MODEL1310110042#
is: SBO:0000176
kinetic law: MODEL1310110042#
fast: false

http://identifiers.org/biomodels.db/MODEL1310110042#_1fc429ae_f48c_4fcd_8a22_89cb4007c41f
initial amount: NaN
has only substance units: false
is: SBO:0000252
name: CA12
constant: false
type: Species
initial concentration: NaN
boundary condition: true
is encoded by: hsa:771

metaM gln L e
boundary condition: false
notes: FORMULA: C5H10N2O3 CHARGE: 0 INCHI: InChI=1S/C5H10N2O3/c6-3(5(9)10)1-2-4(7)8/h3H,1-2,6H2,(H2,7,8)(H,9,10)/t3-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00067
name: L-glutamine
is: SBO:0000247
initial amount: NaN
initial concentration: 1.0
is: CHEBI:18050
is: HMDB00641
constant: false
has only substance units: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110042#_a8d74ac5_1a02_45b4_8404_d3498c39b39b
constant: false
initial concentration: NaN
type: Species
boundary condition: true
has only substance units: false
is encoded by: hsa:7360
initial amount: NaN
name: UGP2
is: SBO:0000252

metaM 34dhmald m
is: C05577
type: Species
has only substance units: false
name: 3,4-Dihydroxymandelaldehyde
is: SBO:0000247
initial amount: NaN
notes: FORMULA: C8H8O4 CHARGE: 0 INCHI: InChI=1/C8H8O4/c9-4-8(12)5-1-2-6(10)7(11)3-5/h1-4,8,10-12H HEPATONET_1.0_ABBREVIATION: HC01514 EHMN_ABBREVIATION: C05577
initial concentration: 1.0
is: http://identifiers.org/pubchem.compound/7903
boundary condition: false
is: HMDB06242
constant: false

metaR F1PGT
product: MODEL1310110042#
name: fucose-1-phosphate guanylyltransferase
fast: false
is version of: http://identifiers.org/ec-code/2.7.7.30
kinetic law: MODEL1310110042#
reversible: true
notes: GENE_ASSOCIATION: (8790.1) SUBSYSTEM: Fructose and mannose metabolism EC Number: 2.7.7.30 Confidence Level: 0 AUTHORS: NOTES:NCD
reactant: MODEL1310110042#
modifier: MODEL1310110042#
is described by: ECO:0000000
is: SBO:0000176
type: Reaction

metaM 2oxoadp m
notes: FORMULA: C6H6O5 CHARGE: -2 INCHI: InChI=1S/C6H8O5/c7-4(6(10)11)2-1-3-5(8)9/h1-3H2,(H,8,9)(H,10,11)/p-2 HEPATONET_1.0_ABBREVIATION: HC00273 EHMN_ABBREVIATION: C00322
is: CHEBI:57499
initial amount: NaN
name: 2-oxoadipate(2-)
has only substance units: false
is: HMDB00225
is: SBO:0000247
constant: false
type: Species
boundary condition: false
initial concentration: 1.0

metaR sink tetdec2coa LPAREN c RPAREN
kinetic law: MODEL1310110042#
reactant: MODEL1310110042#
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: TETDEC2COASINK
type: Reaction

metaR 4MTOLBUTAMIDEte
type: Reaction
name: xenobiotic transport
is: SBO:0000185
fast: false
is described by: ECO:0000000
product: MODEL1310110042#
kinetic law: MODEL1310110042#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:unknown mechanism, related cyp P450 metabolism reactions NJ
reversible: true
reactant: MODEL1310110042#

metaR FAOXC16180m
is version of: http://identifiers.org/ec-code/1.3.99.3
type: Reaction
reversible: false
is version of: http://identifiers.org/ec-code/1.3.8.1
is described by: ECO:0000269
modifier: MODEL1310110042#
kinetic law: MODEL1310110042#
fast: false
is: SBO:0000176
notes: GENE_ASSOCIATION: (35.1) or (34.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.74 Confidence Level: 4 AUTHORS: NOTES:_4 rounds of beta ox, 1 loss of degree of unsat -> only 3 fad oxidized c16:1 -> c8:0 4 step FAO lumped for 2 rounds also includes EC 1.1.1.35, 1.1.1.211, 1.3.3.6, 4.2.1.17, 4.2.1.74 NJ
product: MODEL1310110042#
name: Beta oxidation fatty acid
reactant: MODEL1310110042#

metaM m3mpdol L c
constant: false
initial concentration: 1.0
notes: FORMULA: C1480H2428N20O370P20 CHARGE: -20
is: SBO:0000247
has only substance units: false
boundary condition: false
name: (alpha-D-mannosyl)3-beta-D-mannosyl-diacetylchitodiphosphodolichol, human liver homolog
initial amount: NaN
type: Species
is: CHEBI:37632

metaM cs e deg5 l
notes: FORMULA: C31H47NO35S3 CHARGE: -4
is: CHEBI:57737
is: SBO:0000247
initial amount: NaN
initial concentration: 1.0
boundary condition: false
constant: false
type: Species
has only substance units: false
is: HMDB00868
name: chondroitin sulfate E (GalNAc4,6diS-GlcA), degradation product 5

metaR DMATTx
kinetic law: MODEL1310110042#
is described by: ECO:0000134
name: dimethylallyltranstransferase
notes: GENE_ASSOCIATION: (2224.1) SUBSYSTEM: Cholesterol metabolism EC Number: 2.5.1.1 Confidence Level: 4 AUTHORS: PMID:8188698 NOTES:peroxisomal version - NJ
reactant: MODEL1310110042#
is version of: http://identifiers.org/ec-code/2.5.1.1
product: MODEL1310110042#
fast: false
modifier: MODEL1310110042#
is: SBO:0000176
type: Reaction
reversible: false

metaR EX 10fthf6glu LPAREN e RPAREN
kinetic law: MODEL1310110042#
reactant: MODEL1310110042#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 10-formyltetrahydrofolate-[Glu](6) exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110042#_db0f3c78_8acc_4f7b_b206_dc9a3a3020e0
constant: false
has only substance units: false
is encoded by: hsa:W87865
initial concentration: NaN
name: _W87865_1_c
initial amount: NaN
boundary condition: true
type: Species
is: SBO:0000252

metaM n5m2masn g
is: HMDB00224
type: Species
constant: false
name: ((N-acetyl-D-glucosaminyl)5-(alpha-D-mannosyl)2-beta-D-mannosyl-diacetylchitobiosyl)-L-asparagine (protein)
initial amount: NaN
is: CHEBI:58190
has only substance units: false
initial concentration: 1.0
notes: FORMULA: C74H122N7O50X CHARGE: 0
is: SBO:0000247
boundary condition: false

metaM datp n
is: SBO:0000247
name: dATP
initial concentration: 1.0
is: HMDB01532
initial amount: NaN
constant: false
is: CHEBI:61404
boundary condition: false
notes: FORMULA: C10H12N5O12P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00129 EHMN_ABBREVIATION: C00131
has only substance units: false
type: Species
is: C00131

metaM ksii core2 pre6 g
is: SBO:0000247
initial concentration: 1.0
initial amount: NaN
is: CHEBI:28067
boundary condition: false
constant: false
has only substance units: false
name: keratan sulfate II biosynthesis, precursor 6
notes: FORMULA: C61H98N5O46SX CHARGE: -2
type: Species

metaM 3mgcoa m
type: Species
notes: FORMULA: C27H37N7O19P3S CHARGE: -5 INCHI: InChI=1S/C27H42N7O19P3S/c1-14(8-17(36)37)9-18(38)57-7-6-29-16(35)4-5-30-25(41)22(40)27(2,3)11-50-56(47,48)53-55(45,46)49-10-15-21(52-54(42,43)44)20(39)26(51-15)34-13-33-19-23(28)31-12-32-24(19)34/h8,12-13,15,20-22,26,39-40H,4-7,9-11H2,1-3H3,(H,29,35)(H,30,41)(H,36,37)(H,45,46)(H,47,48)(H2,28,31,32)(H2,42,43,44)/p-5/b14-8+/t15-,20-,21-,22+,26-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01081 EHMN_ABBREVIATION: C03231
is: HMDB01057
is: SBO:0000247
constant: false
initial concentration: 1.0
name: trans-3-methylglutaconyl-CoA(5-)
initial amount: NaN
has only substance units: false
is: CHEBI:57346
boundary condition: false

metaR r0870
is version of: http://identifiers.org/ec-code/3.6.4.13
name: Facilitated diffusion
reversible: true
reactant: MODEL1310110042#
notes: GENE_ASSOCIATION: (AA419122.1) or (AA576959.1) or (64077.1) or (8776.1) or (8898.1) or (9107.1) or (29085.1) or (8611.1) or (8613.1) or (8612.1) or (81537.1) or (130367.1) or (23517.1) or (51095.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14977409,PMID:17466261 NOTES:
kinetic law: MODEL1310110042#
is version of: http://identifiers.org/ec-code/3.1.3.4
is version of: http://identifiers.org/ec-code/3.6.1.1
is version of: http://identifiers.org/ec-code/2.7.7.72
is described by: ECO:0000000
type: Reaction
fast: false
modifier: MODEL1310110042#
product: MODEL1310110042#
is: SBO:0000185

metaR NDPK4
kinetic law: MODEL1310110042#
is: SBO:0000176
type: Reaction
fast: false
product: MODEL1310110042#
modifier: MODEL1310110042#
notes: GENE_ASSOCIATION: (4832.1) or (4831.1 and 4830.1) or (10201.1) or (29922.2) or (29922.1) or (4831.1 and 4830.2) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: NOTES:
is version of: http://identifiers.org/ec-code/2.7.4.6
reactant: MODEL1310110042#
name: nucleoside-diphosphate kinase (ATP:dTDP)
is described by: ECO:0000269
reversible: true

metaM dhea c
initial concentration: 1.0
notes: FORMULA: C19H28O2 CHARGE: 0 INCHI: InChI=1S/C19H28O2/c1-18-9-7-13(20)11-12(18)3-4-14-15-5-6-17(21)19(15,2)10-8-16(14)18/h3,13-16,20H,4-11H2,1-2H3/t13-,14-,15-,16-,18-,19-/m0/s1 EHMN_ABBREVIATION: C01227
boundary condition: false
has only substance units: false
initial amount: NaN
name: 3beta-hydroxyandrost-5-en-17-one
is: CHEBI:28689
is: SBO:0000247
is: HMDB00077
constant: false
type: Species

metaM g6p r
initial amount: NaN
notes: FORMULA: C6H11O9P CHARGE: -2 INCHI: "1/C5H11/c1-3-5-4-2/h1,3-5H2,2H3 HEPATONET_1.0_ABBREVIATION: HC00094 EHMN_ABBREVIATION: C00092
name: D-Glucose 6-phosphate
has only substance units: false
is: HMDB01401
is: C00092
boundary condition: false
is: CHEBI:61548
initial concentration: 1.0
type: Species
constant: false
is: SBO:0000247

metaR NDPK3
kinetic law: MODEL1310110042#
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/2.7.4.6
name: nucleoside-diphosphate kinase (ATP:CDP)
notes: GENE_ASSOCIATION: (4832.1) or (29922.2) or (4831.1 and 4830.1) or (29922.1) or (10201.1) or (4831.1 and 4830.2) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: NOTES:
fast: false
modifier: MODEL1310110042#
reactant: MODEL1310110042#
reversible: true
type: Reaction
product: MODEL1310110042#
is: SBO:0000176

metaR CAROtr
fast: false
reactant: MODEL1310110042#
reversible: true
product: MODEL1310110042#
type: Reaction
kinetic law: MODEL1310110042#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:1503811 NOTES:IT
is: SBO:0000185
is described by: ECO:0000000
name: beta-carotene transport via diffusion

metaR r0549
reversible: true
is: SBO:0000176
modifier: MODEL1310110042#
product: MODEL1310110042#
is version of: http://identifiers.org/ec-code/6.1.1.17
is version of: http://identifiers.org/ec-code/1.6.99.3
name: 4-aminobutanal:NAD+ 1-oxidoreductase; 4-aminobutyraldehyde:NAD+ oxidoreductase Urea cycle and metabolism of amino groups / beta-Alanine metabolism EC:1.2.1.3 EC:1.2.1.19
reactant: MODEL1310110042#
kinetic law: MODEL1310110042#
fast: false
notes: GENE_ASSOCIATION: (AA629629.1) or (AA854479.1) or (AI345944.1) or (AI378339.1) or (AI601100.1) or (AI631997.1) or (AI935189.1) or (124454.1) or (F23536.1) or (FLJ44968.1) or (H45672.1) or (H53099.1) or (3550.1) or (LOC727762.1) or (4694.1) or (4705.1) or (126328.1) or (55967.1) or (51079.1) or (4695.1) or (4696.1) or (4697.1) or (56901.1) or (4698.1) or (4700.1) or (4701.1) or (4702.1) or (4704.1) or (4706.1) or (4707.1) or (4716.1) or (54539.1) or (4708.1) or (4709.1) or (4710.1) or (4711.1) or (4712.1) or (4713.1) or (4714.1) or (4715.1) or (4717.1) or (4718.1) or (4719.1) or (4720.1) or (4722.1) or (4724.1) or (4725.1) or (4726.1) or (374291.1) or (4728.1) or (4723.1) or (4729.1) or (4731.1) SUBSYSTEM: Glutamate metabolism EC Number: 1.2.1.3 Confidence Level: 0 AUTHORS: PMID:2925663,PMID:8155713,PMID:8269919,PMID:8786138,PMID:9417993 NOTES:
type: Reaction
is version of: http://identifiers.org/ec-code/1.6.5.3
is described by: ECO:0000000

metaR FAOXC165C164m
kinetic law: MODEL1310110042#
product: MODEL1310110042#
reactant: MODEL1310110042#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation (C16:5-->C16:4)m
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110042#_81e85c72_aaf9_45cc_b826_f6f03e8108df
name: BAAT
initial concentration: NaN
has only substance units: false
type: Species
is: Q14032
initial amount: NaN
constant: false
boundary condition: true
is: SBO:0000252
is encoded by: hsa:570

metaR 5ADTSTSTERONESULT
name: 5alpha-Dihydrotestosterone sulfotransferase
reversible: false
type: Reaction
product: MODEL1310110042#
fast: false
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (6822.1) SUBSYSTEM: Steroid metabolism EC Number: 2.8.2.2 Confidence Level: 4 AUTHORS: PMID:1588921,PMID:16399349 NOTES:NJ
is version of: http://identifiers.org/ec-code/2.8.2.14
reactant: MODEL1310110042#
kinetic law: MODEL1310110042#
modifier: MODEL1310110042#
is: SBO:0000176

metaR r0647
product: MODEL1310110042#
is described by: ECO:0000000
name: Spontaneous reaction
type: Reaction
is: SBO:0000176
reversible: true
fast: false
kinetic law: MODEL1310110042#
notes: GENE_ASSOCIATION: SUBSYSTEM: Tryptophan metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:18124509,PMID:6027578 NOTES:
reactant: MODEL1310110042#

metaM datp m
name: dATP
initial concentration: 1.0
initial amount: NaN
constant: false
notes: FORMULA: C10H12N5O12P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00129 EHMN_ABBREVIATION: C00131
is: HMDB01532
has only substance units: false
boundary condition: false
type: Species
is: C00131
is: CHEBI:61404
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110042#_742f003f_6f57_441e_935b_0820001c9d1e
has only substance units: false
initial amount: NaN
is: P53794
constant: false
name: SLC5A3
is encoded by: hsa:6526
is: SBO:0000252
boundary condition: true
initial concentration: NaN
type: Species

http://identifiers.org/biomodels.db/MODEL1310110042#_556f9147_6e56_464c_95ed_c81e9d48d041
type: Species
is: SBO:0000252
is encoded by: hsa:6533
initial concentration: NaN
is: Q9BRI2
initial amount: NaN
name: SLC6A6
boundary condition: true
constant: false
has only substance units: false

metaR NDPK5
modifier: MODEL1310110042#
notes: GENE_ASSOCIATION: (4832.1) or (4831.1 and 4830.2) or (10201.1) or (29922.2) or (29922.1) or (4831.1 and 4830.1) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: NOTES:
is described by: ECO:0000269
kinetic law: MODEL1310110042#
fast: false
name: Nucleoside-diphosphate kinase (ATP:dGDP)
product: MODEL1310110042#
reversible: true
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.7.4.6
type: Reaction
reactant: MODEL1310110042#

metaM g3m8mpdol U r
boundary condition: false
name: (alpha-D-Glucosyl)3-(alpha-D-mannosyl)8-beta-D-mannosyl-diacetylchitobiosyldiphosphodolichol, human uterine homolog
has only substance units: false
constant: false
is: C05873
initial concentration: 1.0
type: Species
is: SBO:0000247
notes: FORMULA: C1905H3140N20O770P20 CHARGE: -20
initial amount: NaN

metaM n3m2masn g
type: Species
initial concentration: 1.0
is: SBO:0000247
notes: FORMULA: C58H96N5O40X CHARGE: 0
constant: false
has only substance units: false
is: C05881
boundary condition: false
initial amount: NaN
name: ((N-acetyl-D-glucosaminyl)3-(alpha-D-mannosyl)2-beta-D-mannosyl-diacetylchitobiosyl)-L-asparagine (protein)

http://identifiers.org/biomodels.db/MODEL1310110042#_fcb18061_dc6f_490c_98ad_dfa85b1ed200
initial amount: NaN
constant: false
type: Species
has only substance units: false
initial concentration: NaN
boundary condition: true
name: LDHD
is encoded by: hsa:197257
is: SBO:0000252
is: Q86WU2

http://identifiers.org/biomodels.db/MODEL1310110042#_b4387529_4359_4e00_9e7f_ec3df58190d7
initial concentration: NaN
is encoded by: hsa:6550
name: SLC9A3
is: P48764
is: SBO:0000252
has only substance units: false
initial amount: NaN
type: Species
constant: false
boundary condition: true

metaR C6DCc
kinetic law: MODEL1310110042#
product: MODEL1310110042#
reactant: MODEL1310110042#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: production of adipoylcarnitine
type: Reaction

metaR H2CO3D
type: Reaction
modifier: MODEL1310110042#
reversible: true
reactant: MODEL1310110042#
kinetic law: MODEL1310110042#
fast: false
is version of: http://identifiers.org/ec-code/4.2.1.1
product: MODEL1310110042#
is: SBO:0000176
notes: GENE_ASSOCIATION: (761.1) or (771.1) or (377677.1) or (762.1) or (766.2) or (23632.1) or (766.1) or (771.2) or (759.1) or (768.1) or (760.1) SUBSYSTEM: Miscellaneous EC Number: 4.2.1.1 Confidence Level: 0 AUTHORS: PMID:11101628,PMID:11172051,PMID:11676494,PMID:14600151,PMID:7574487 NOTES:tv
name: carboxylic acid dissociation
is described by: ECO:0000000

metaR NDPK6
reversible: true
type: Reaction
name: Nucleoside-diphosphate kinase (ATP:dUDP)
fast: false
kinetic law: MODEL1310110042#
product: MODEL1310110042#
notes: GENE_ASSOCIATION: (4832.1) or (4831.1 and 4830.1) or (10201.1) or (29922.2) or (29922.1) or (4831.1 and 4830.2) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: NOTES:
modifier: MODEL1310110042#
reactant: MODEL1310110042#
is version of: http://identifiers.org/ec-code/2.7.4.6
is described by: ECO:0000269
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110042#_a7d30c1c_a189_4d6f_9550_fd91902be076
is encoded by: hsa:84532
has only substance units: false
boundary condition: true
initial concentration: NaN
type: Species
is: SBO:0000252
is: Q9NUB1
constant: false
initial amount: NaN
name: ACSS1

http://identifiers.org/biomodels.db/MODEL1310110042#_437e6b2e_7b49_48a1_9791_66e44babb128
initial amount: NaN
boundary condition: true
type: Species
is encoded by: hsa:641372
constant: false
initial concentration: NaN
is: Q3I5F7
name: ACOT6
has only substance units: false
is: SBO:0000252

metaM gacpail hs r
initial amount: NaN
has only substance units: false
is: CHEBI:16344
name: glucosaminyl-acylphosphatidylinositol
boundary condition: false
constant: false
initial concentration: 1.0
is: SBO:0000247
type: Species
notes: FORMULA: C31H58NO14PFULLRCO2FULLR2CO2 CHARGE: 0
is: HMDB00128

metaR sink 5hpet LPAREN c RPAREN
kinetic law: MODEL1310110042#
reactant: MODEL1310110042#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: sink reaction for 5(S)-HPETE(1-)
type: Reaction

metaR O2tn
name: O2 nuclear transport
is described by: ECO:0000000
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD
kinetic law: MODEL1310110042#
reversible: true
product: MODEL1310110042#
reactant: MODEL1310110042#
fast: false
is: SBO:0000185

metaM focytC m
constant: false
has only substance units: false
initial concentration: 1.0
is: SBO:0000247
notes: FORMULA: C42H54FeN8O6S2 CHARGE: 2 HEPATONET_1.0_ABBREVIATION: HC00124
is: CHEBI:16928
type: Species
boundary condition: false
name: Ferrocytochrome C
initial amount: NaN

metaR FAOXC102m
kinetic law: MODEL1310110042#
product: MODEL1310110042#
reactant: MODEL1310110042#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: isomerization(C10:2)m
type: Reaction

metaM g1m8mpdol U r
is: SBO:0000247
initial concentration: 1.0
name: alpha-D-Glucosyl-(alpha-D-mannosyl)8-beta-D-mannosyl-diacetylchitobiosyldiphosphodolichol, human uterine homolog
notes: FORMULA: C1785H2940N20O670P20 CHARGE: -20
has only substance units: false
constant: false
is: CHEBI:59093
type: Species
initial amount: NaN
boundary condition: false

metaM ser L m
boundary condition: false
type: Species
initial concentration: 1.0
is: CHEBI:17115
is: HMDB00187
notes: FORMULA: C3H7NO3 CHARGE: 0 INCHI: InChI=1S/C3H7NO3/c4-2(1-5)3(6)7/h2,5H,1,4H2,(H,6,7)/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00068
constant: false
name: L-serine
initial amount: NaN
is: SBO:0000247
has only substance units: false

metaR NDPK7
is described by: ECO:0000269
modifier: MODEL1310110042#
name: nucleoside-diphosphate kinase (ATP:dCDP)
fast: false
kinetic law: MODEL1310110042#
is: SBO:0000176
product: MODEL1310110042#
notes: GENE_ASSOCIATION: (4832.1) or (4831.1 and 4830.1) or (10201.1) or (29922.2) or (29922.1) or (4831.1 and 4830.2) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: NOTES:
reversible: true
type: Reaction
reactant: MODEL1310110042#
is version of: http://identifiers.org/ec-code/2.7.4.6

metaR O2tp
name: O2 transport, peroxisomal
type: Reaction
product: MODEL1310110042#
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD
is: SBO:0000185
fast: false
kinetic law: MODEL1310110042#
reactant: MODEL1310110042#
is described by: ECO:0000000

metaR CSBPASEly
notes: GENE_ASSOCIATION: SUBSYSTEM: Chondroitin sulfate degradation EC Number: Confidence Level: 1 AUTHORS: PMID:8993162 NOTES:Note that this reaction occurs in the endosome during endocytosis, but has been compartmentalized as lysosomal. NCD
reactant: MODEL1310110042#
fast: false
product: MODEL1310110042#
type: Reaction
name: chondroitin sulfate B proteoglycan protease, lysosome (endosome)
is described by: ECO:0000000
kinetic law: MODEL1310110042#
is: SBO:0000176
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110042#_3bfd65c2_af42_490b_bba7_4aa60804718e
boundary condition: true
is encoded by: hsa:6241
initial concentration: NaN
is: P31350
name: RRM2
has only substance units: false
type: Species
is: SBO:0000252
initial amount: NaN
constant: false

metaM ksii core2 pre8 g
initial amount: NaN
notes: FORMULA: C75H121N6O56SX CHARGE: -2
is: SBO:0000247
is: HMDB00175
is: C00130
name: keratan sulfate II biosynthesis, precursor 8
initial concentration: 1.0
boundary condition: false
constant: false
has only substance units: false
is: CHEBI:58053
type: Species

metaR FAOXC141C121x
kinetic law: MODEL1310110042#
product: MODEL1310110042#
reactant: MODEL1310110042#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta xoidation(C14:1-->C12:1)x
type: Reaction

metaR 34HPPOR
reversible: false
name: 4-Hydroxyphenylpyruvate:oxygen oxidoreductase
is version of: http://identifiers.org/ec-code/1.13.11.27
product: MODEL1310110042#
type: Reaction
kinetic law: MODEL1310110042#
is: SBO:0000176
modifier: MODEL1310110042#
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (3242.1) SUBSYSTEM: Tyrosine metabolism EC Number: 1.13.11.27 Confidence Level: 4 AUTHORS: NOTES:
reactant: MODEL1310110042#
fast: false

metaM 10fthf e
has only substance units: false
boundary condition: false
is: CHEBI:57454
name: 10-formyltetrahydrofolate(2-)
initial concentration: 1.0
constant: false
is: HMDB00972
type: Species
notes: FORMULA: C20H21N7O7 CHARGE: -2 INCHI: InChI=1S/C20H23N7O7/c21-20-25-16-15(18(32)26-20)23-11(7-22-16)8-27(9-28)12-3-1-10(2-4-12)17(31)24-13(19(33)34)5-6-14(29)30/h1-4,9,11,13,23H,5-8H2,(H,24,31)(H,29,30)(H,33,34)(H4,21,22,25,26,32)/p-2/t11-,13+/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00212 EHMN_ABBREVIATION: C00234
is: SBO:0000247
initial amount: NaN

metaR D LACt2
is described by: ECO:0000269
product: MODEL1310110042#
fast: false
reactant: MODEL1310110042#
notes: GENE_ASSOCIATION: (9194.1) or (23539.1) or (6566.1) or (9123.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10493836,PMID:10510291,PMID:11101640,PMID:12739169,PMID:7835905,PMID:8476015,PMID:9425115,PMID:9508842,PMID:9649795,PMID:9786900,PMID:9824713 NOTES:JLR
reversible: true
kinetic law: MODEL1310110042#
modifier: MODEL1310110042#
type: Reaction
is: SBO:0000185
name: D-lactate transport via proton symport

metaM hs deg20 l
boundary condition: false
initial concentration: 1.0
name: heparan sulfate, degradation product 20
initial amount: NaN
has only substance units: false
constant: false
notes: FORMULA: C45H68N2O43S2 CHARGE: -4
is: CHEBI:16126
is: SBO:0000247
type: Species

metaR NDPK8
is described by: ECO:0000269
reactant: MODEL1310110042#
type: Reaction
modifier: MODEL1310110042#
fast: false
reversible: true
product: MODEL1310110042#
is version of: http://identifiers.org/ec-code/2.7.4.6
notes: GENE_ASSOCIATION: (4832.1) or (4831.1 and 4830.1) or (10201.1) or (29922.2) or (29922.1) or (4831.1 and 4830.2) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: NOTES:
kinetic law: MODEL1310110042#
name: Nucleoside-diphosphate kinase (ATP:dADP)
is: SBO:0000176

metaR r0644
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 1.2.3.1 Confidence Level: 0 AUTHORS: PMID:11569919,PMID:16143537 NOTES:
type: Reaction
is: SBO:0000176
fast: false
reversible: true
kinetic law: MODEL1310110042#
reactant: MODEL1310110042#
name: (S)-Methylmalonate semialdehyde:oxygen oxidoreductase Valine, leucine and isoleucine degradation EC:1.2.3.1
product: MODEL1310110042#
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110042#_1d0ccac0_c125_4e3a_b86c_35ebe2454976
is: Q5JPA4
boundary condition: true
type: Species
is: SBO:0000252
constant: false
has only substance units: false
initial amount: NaN
initial concentration: NaN
name: SLCO1C1
is encoded by: hsa:53919

metaR ARGtiDF
notes: GENE_ASSOCIATION: (6541.1) or (6542.1) or (55089.1) or (84889.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:11342143,PMID:11414754,PMID:11591158,PMID:11891586,PMID:12049641,PMID:1348489,PMID:14770310,PMID:7534987,PMID:8954799 NOTES:SAB
name: L-arginine transport via diffusion (extracellular to cytosol)
is: SBO:0000185
product: MODEL1310110042#
is described by: ECO:0000269
reactant: MODEL1310110042#
kinetic law: MODEL1310110042#
fast: false
reversible: false
type: Reaction
modifier: MODEL1310110042#

http://identifiers.org/biomodels.db/MODEL1310110042#_f9cff947_e749_4261_a062_0cce06984368
is encoded by: hsa:5214
has only substance units: false
type: Species
constant: false
name: PFKP
boundary condition: true
initial concentration: NaN
initial amount: NaN
is: Q5VSR7
is: SBO:0000252

metaR 3HCO3 NAt
name: 3HCO3_NAt
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID: 11875267, PMID: 18077606. NOTES:Na/hco3 co-transporter, expressed at the basolateral side, meant for uptake of hco3, expressed highly in the intestine (NBC1).
reversible: true
reactant: MODEL1310110042#
fast: false
is: SBO:0000185
kinetic law: MODEL1310110042#
product: MODEL1310110042#
type: Reaction
is described by: ECO:0000134

metaR EX cit LPAREN e RPAREN
kinetic law: MODEL1310110042#
reactant: MODEL1310110042#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Citrate exchange
type: Reaction

metaM ksi pre29 g
notes: FORMULA: C213H340N15O179S9X CHARGE: -10
name: keratan sulfate I biosynthesis, precursor 29
initial amount: NaN
constant: false
type: Species
has only substance units: false
is: CHEBI:28067
initial concentration: 1.0
is: SBO:0000247
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110042#_5a01d9e1_ad50_40b1_9dd7_f7ae80e12711
constant: false
name: SLC7A3
is: SBO:0000252
is: Q8WY07
initial amount: NaN
type: Species
initial concentration: NaN
has only substance units: false
boundary condition: true
is encoded by: hsa:84889

http://identifiers.org/biomodels.db/MODEL1310110042#_50ac6de7_43db_4fcb_a170_39b205e2d325
type: Species
has part: Q9H3S5
constant: false
name: PIGX:PIGM
initial concentration: NaN
boundary condition: true
has part: Q8TBF5
is: SBO:0000297
initial amount: NaN
is encoded by: hsa:54965
is encoded by: hsa:93183
has only substance units: false

metaR r0545
is described by: ECO:0000000
product: MODEL1310110042#
kinetic law: MODEL1310110042#
is: SBO:0000176
reactant: MODEL1310110042#
fast: false
reversible: true
name: Phenylacetaldehyde:NAD+ oxidoreductase Phenylalanine metabolism / Styrene degradation EC:1.2.1.5 EC:1.2.1.39
is version of: http://identifiers.org/ec-code/3.6.1.5
notes: GENE_ASSOCIATION: (AV717590.1) or (953.1) or (956.1) or (377841.1) SUBSYSTEM: Phenylalanine metabolism EC Number: 1.2.1.5 Confidence Level: 0 AUTHORS: PMID:15230339 NOTES:
type: Reaction
modifier: MODEL1310110042#

http://identifiers.org/biomodels.db/MODEL1310110042#_1de8f857_8e8a_4c49_9d0d_007b458b3fcf
is encoded by: hsa:10905
is: O60476
is: SBO:0000252
boundary condition: true
name: MAN1A2
has only substance units: false
constant: false
type: Species
initial concentration: NaN
initial amount: NaN

metaM m7mpdol U r
is: CHEBI:37636
constant: false
is: SBO:0000247
initial concentration: 1.0
name: (alpha-D-Mannosyl)7-beta-D-mannosyl-diacetylchitobiosyldiphosphodolichol, human uterine homolog
notes: FORMULA: C1665H2740N20O570P20 CHARGE: -20
has only substance units: false
initial amount: NaN
boundary condition: false
type: Species

metaR HMGCOARc
type: Reaction
reactant: MODEL1310110042#
reversible: false
fast: false
product: MODEL1310110042#
name: Hydroxymethylglutaryl CoA reductase (ir) in cytosol
notes: GENE_ASSOCIATION: (3156.1) SUBSYSTEM: Squalene and cholesterol synthesis EC Number: Confidence Level: 4 AUTHORS: Davidson, N. O., Magun, A. M. and Glickman, R. M. 2011. Enterocyte Lipid Absorption and Secretion. Comprehensive Physiology. 505?526, PMID: 17015489, PMID: 18216769, PMID: 6833883, PMID: 11229876. NOTES:Enterocytes stand next to liver in endogenous cholesterol synthesis. in rats they provide 25% of bodys cholesterol. the crypt epithelial cells synthesize maximum cholesterol when compared to other parts of the GI tract (PMCID: PMC292609). enzyme is located in E.R. but has catalytic site facing the cytosol (D.S. Sheriff (2004) Medical biochemistry, 1st edition Jaypee brothers Medical publishers pvt ltd page 502).
modifier: MODEL1310110042#
kinetic law: MODEL1310110042#
is: SBO:0000176
is described by: ECO:0000134
is version of: http://identifiers.org/ec-code/1.1.1.34

metaR HMBS
name: hydroxymethylbilane synthase
type: Reaction
is: SBO:0000176
is described by: ECO:0000254
kinetic law: MODEL1310110042#
reversible: false
is version of: http://identifiers.org/ec-code/2.5.1.61
product: MODEL1310110042#
notes: GENE_ASSOCIATION: (3145.1) SUBSYSTEM: Heme synthesis EC Number: 4.3.1.8 Confidence Level: 2 AUTHORS: PMID:2875434 NOTES:
modifier: MODEL1310110042#
reactant: MODEL1310110042#
fast: false

metaR r0643
fast: false
name: (S)-Methylmalonate semialdehyde:NAD+ oxidoreductase Valine, leucine and isoleucine degradation EC:1.2.1.3
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 1.2.1.3 Confidence Level: 0 AUTHORS: PMID:10947204,PMID:10989432,PMID:1527093,PMID:16683190,PMID:8120000,PMID:8155713,PMID:8634152,PMID:9787093 NOTES:
kinetic law: MODEL1310110042#
reactant: MODEL1310110042#
type: Reaction
is: SBO:0000176
product: MODEL1310110042#
reversible: true

metaR NDPK9
kinetic law: MODEL1310110042#
modifier: MODEL1310110042#
is described by: ECO:0000269
reactant: MODEL1310110042#
reversible: true
name: nucleoside-diphosphate kinase (ATP:IDP)
is: SBO:0000176
notes: GENE_ASSOCIATION: (4832.1) or (4831.1 and 4830.1) or (10201.1) or (29922.2) or (29922.1) or (4831.1 and 4830.2) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.6 Confidence Level: 4 AUTHORS: NOTES:NCD
type: Reaction
fast: false
product: MODEL1310110042#
is version of: http://identifiers.org/ec-code/2.7.4.6

metaR HS4ly
type: Reaction
product: MODEL1310110042#
name: heparan-N-sulfatase, lysosomal
is described by: ECO:0000000
reactant: MODEL1310110042#
notes: GENE_ASSOCIATION: (6448.1) SUBSYSTEM: Heparan sulfate degradation EC Number: 3.10.1.1 Confidence Level: 4 AUTHORS: PMID:7493035,PMID:8993162,PMID:9405287 NOTES:NCD
modifier: MODEL1310110042#
reversible: false
fast: false
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.10.1.1
kinetic law: MODEL1310110042#

metaR EX pan4p LPAREN e RPAREN
kinetic law: MODEL1310110042#
reactant: MODEL1310110042#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for pan4p
type: Reaction

metaM dolp L c
boundary condition: false
type: Species
is: CHEBI:57683
has only substance units: false
initial concentration: 1.0
constant: false
name: dolichyl phosphate(2-)
notes: FORMULA: C1080H1758O40P10 CHARGE: -20 INCHI: InChI=1S/C25H45O4P/c1-21(2)11-7-12-22(3)13-8-14-23(4)15-9-16-24(5)17-10-18-25(6)19-20-29-30(26,27)28/h11,13,15,17,25H,7-10,12,14,16,18-20H2,1-6H3,(H2,26,27,28)/p-2/b22-13+,23-15+,24-17- EHMN_ABBREVIATION: C00110
is: SBO:0000247
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110042#_8054f4b6_de48_4839_b56a_b3687bfad0c2
type: Species
initial amount: NaN
name: PPT2
is: Q9UMR5
boundary condition: true
has only substance units: false
constant: false
is encoded by: hsa:9374
is: SBO:0000252
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110042#_8e280aae_abf5_4a01_a18b_1e2f81d7d8ea
is encoded by: hsa:9563
type: Species
is: O95479
boundary condition: true
initial concentration: NaN
name: H6PD
constant: false
initial amount: NaN
is: SBO:0000252
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110042#_7f88daf7_1860_4b91_b8a2_5ed72bfa8a7d
is: Q53H96
is: SBO:0000252
initial amount: NaN
boundary condition: true
constant: false
initial concentration: NaN
has only substance units: false
is encoded by: hsa:65263
name: PYCRL
type: Species

http://identifiers.org/biomodels.db/MODEL1310110042#_1901f127_3bfd_4c40_953c_593d1cf46c8b
name: SLC6A12
is: SBO:0000252
is encoded by: hsa:6539
initial concentration: NaN
has only substance units: false
constant: false
initial amount: NaN
boundary condition: true
type: Species
is: P48065

http://identifiers.org/biomodels.db/MODEL1310110042#_0ecf9f72_1b00_4196_b8c3_67b110e1f582
is encoded by: hsa:4122
is: SBO:0000252
initial amount: NaN
has only substance units: false
type: Species
is: Q9P1E4
constant: false
boundary condition: true
initial concentration: NaN
name: MAN2A2

metaM lnlncacrn m
initial concentration: 1.0
has only substance units: false
initial amount: NaN
constant: false
type: Species
is: SBO:0000247
name: alpha-linolenyl carnitine
notes: FORMULA: C25H43NO4 CHARGE: 0 INCHI: InChI=1/C25H43NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-25(29)30-23(26(2,3)4)21-22-24(27)28/h6-7,9-10,12-13,23H,5,8,11,14-22H2,1-4H3/b7-6-,10-9-,13-12-/t23-/m0/s1
is: HMDB06319
boundary condition: false

metaR SACCD3m
reactant: MODEL1310110042#
type: Reaction
is described by: ECO:0000269
fast: false
notes: GENE_ASSOCIATION: (10157.1) SUBSYSTEM: Lysine metabolism EC Number: 1.5.1.8 Confidence Level: 4 AUTHORS: PMID:10775527 NOTES:MM
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.5.1.8
name: saccharopine dehydrogenase (NADP, L-lysine forming), mitochondrial
product: MODEL1310110042#
modifier: MODEL1310110042#
reversible: false
kinetic law: MODEL1310110042#

metaR LGTHL
name: lactoylglutathione lyase
is: SBO:0000176
reactant: MODEL1310110042#
product: MODEL1310110042#
fast: false
type: Reaction
is version of: http://identifiers.org/ec-code/4.4.1.5
notes: GENE_ASSOCIATION: (2739.1) SUBSYSTEM: Pyruvate metabolism EC Number: 4.4.1.5 Confidence Level: 4 AUTHORS: PMID:7684374,PMID:8449929 NOTES:IF
is described by: ECO:0000269
kinetic law: MODEL1310110042#
modifier: MODEL1310110042#
reversible: false

metaR CHSTEROLtrc
type: Reaction
kinetic law: MODEL1310110042#
product: MODEL1310110042#
is: SBO:0000185
reactant: MODEL1310110042#
name: transport of cholesterol into the cytosol
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: PMID: 11229876 NOTES:newly synthesized cholesterol may either be incorporated into membrane or transported out of enterocytes.
fast: false
is described by: ECO:0000134
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110042#_d0821d51_4b29_442c_a487_58bf9cff7b33
is: Q16718
boundary condition: true
type: Species
constant: false
has only substance units: false
is: SBO:0000252
initial amount: NaN
name: NDUFA5
is encoded by: hsa:4698
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110042#_20ed05b0_7737_44bd_a8c5_31c8abb87c07
boundary condition: true
constant: false
initial amount: NaN
has only substance units: false
is: SBO:0000252
name: FOLR1
type: Species
is encoded by: hsa:2348
initial concentration: NaN

metaM pydam c
constant: false
is: HMDB01431
is: C00534
has only substance units: false
boundary condition: false
initial concentration: 1.0
name: Pyridoxamine
type: Species
is: SBO:0000247
notes: FORMULA: C8H13N2O2 CHARGE: 1 HEPATONET_1.0_ABBREVIATION: HC00416 EHMN_ABBREVIATION: C00534
initial amount: NaN
is: CHEBI:57761

metaR HBZOPT10m
kinetic law: MODEL1310110042#
name: Hydroxybenzoate Decaprenyltransferase
fast: false
is version of: http://identifiers.org/ec-code/2.5.1.39
is: SBO:0000176
type: Reaction
reactant: MODEL1310110042#
modifier: MODEL1310110042#
notes: GENE_ASSOCIATION: (27235.1) SUBSYSTEM: Ubiquinone synthesis EC Number: Confidence Level: 4 AUTHORS: PMID:15153069,PMID:1965190,PMID:7380842 NOTES:Used to make Ubiquinone-10 EC 2.5.1.- IT
product: MODEL1310110042#
reversible: false
is described by: ECO:0000269

http://identifiers.org/biomodels.db/MODEL1310110042#_94922f43_b399_449e_9dac_32f86941192f
is encoded by: hsa:130
initial amount: NaN
constant: false
is: P28332
type: Species
initial concentration: NaN
name: ADH6
has only substance units: false
boundary condition: true
is: SBO:0000252

metaR r0642
is described by: ECO:0000000
name: (S)-Methylmalonate semialdehyde:NAD+ oxidoreductase Valine, leucine and isoleucine degradation EC:1.2.1.3
type: Reaction
is: SBO:0000176
reactant: MODEL1310110042#
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 1.2.1.3 Confidence Level: 0 AUTHORS: PMID:10947204,PMID:10989432,PMID:1527093,PMID:16683190,PMID:8120000,PMID:8155713,PMID:8634152,PMID:9787093 NOTES:
product: MODEL1310110042#
kinetic law: MODEL1310110042#
reversible: true
fast: false

http://identifiers.org/biomodels.db/MODEL1310110042#_d23aca66_cccf_403c_8d37_991684188c5c
name: COX8C
is: Q7Z4L0
constant: false
initial concentration: NaN
is encoded by: hsa:341947
boundary condition: true
initial amount: NaN
is: SBO:0000252
type: Species
has only substance units: false

metaR DHFR
kinetic law: MODEL1310110042#
is described by: ECO:0000254
reactant: MODEL1310110042#
fast: false
is: SBO:0000176
modifier: MODEL1310110042#
is version of: http://identifiers.org/ec-code/1.5.1.3
name: dihydrofolate reductase
reversible: true
notes: GENE_ASSOCIATION: (1719.1) SUBSYSTEM: Folate metabolism EC Number: 1.5.1.3 Confidence Level: 2 AUTHORS: PMID:6504041 NOTES:
type: Reaction
product: MODEL1310110042#

http://identifiers.org/biomodels.db/MODEL1310110042#_e8c92547_1930_42c7_9756_dbd567bee9c6
constant: false
initial amount: NaN
type: Species
is encoded by: hsa:5152
initial concentration: NaN
boundary condition: true
name: PDE9A
has only substance units: false
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110042#_7452907f_7e52_4774_abd0_268d9a704e61
type: Species
name: BTD
initial concentration: NaN
is: SBO:0000252
constant: false
is encoded by: hsa:686
is: P43251
boundary condition: true
initial amount: NaN
has only substance units: false

metaR THD1m
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (23530.2) or (23530.1) SUBSYSTEM: NAD metabolism EC Number: 1.6.1.2 Confidence Level: 4 AUTHORS: PMID:12223207,PMID:8647343,PMID:9524818 NOTES:TDV (2-6-2003)
fast: false
is: SBO:0000185
reversible: true
is version of: http://identifiers.org/ec-code/1.6.1.2
modifier: MODEL1310110042#
type: Reaction
name: NAD(P) transhydrogenase
kinetic law: MODEL1310110042#
product: MODEL1310110042#
reactant: MODEL1310110042#

metaR THMDt5le
reversible: false
product: MODEL1310110042#
kinetic law: MODEL1310110042#
notes: GENE_ASSOCIATION: (64078.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
type: Reaction
is: SBO:0000185
is described by: ECO:0000134
reactant: MODEL1310110042#
modifier: MODEL1310110042#
fast: false
name: thymidine transport (1:2 Na/Thymd cotransport)

metaM ksi pre9 g
is: SBO:0000247
initial concentration: 1.0
constant: false
type: Species
is: C00130
name: keratan sulfate I biosynthesis, precursor 9
boundary condition: false
has only substance units: false
initial amount: NaN
is: HMDB00175
is: CHEBI:58053
notes: FORMULA: C121H196N8O93S2X CHARGE: -3

http://identifiers.org/biomodels.db/MODEL1310110042#_f6d37808_e8cb_4ced_ba79_d35445eb7535
has only substance units: false
is: SBO:0000252
initial amount: NaN
constant: false
is: Q86VV3
initial concentration: NaN
boundary condition: true
is encoded by: hsa:953
type: Species
name: ENTPD1

http://identifiers.org/biomodels.db/MODEL1310110042#_024c745e_a469_40f6_8c23_8125f59e5558
boundary condition: true
initial amount: NaN
type: Species
initial concentration: NaN
name: SLC2A14
is: Q8TDB8
has only substance units: false
is: SBO:0000252
constant: false
is encoded by: hsa:144195

metaM tetpent6coa c
constant: false
type: Species
boundary condition: false
initial concentration: 1.0
name: tetracosapentaenoyl coenzyme A, n-6
is: SBO:0000247
initial amount: NaN
is: C16172
notes: FORMULA: C45H68N7O17P3S CHARGE: -4 INCHI: InChI=1/C45H72N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-24-25-36(54)73-29-28-47-35(53)26-27-48-43(57)40(56)45(2,3)31-66-72(63,64)69-71(61,62)65-30-34-39(68-70(58,59)60)38(55)44(67-34)52-33-51-37-41(46)49-32-50-42(37)52/h8-9,11-12,14-15,17-18,20-21,32-34,38-40,44,55-56H,4-7,10,13,16,19,22-31H2,1-3H3,(H,47,53)(H,48,57)(H,61,62)(H,63,64)(H2,46,49,50)(H2,58,59,60)/b9-8-,12-11-,15-14-,18-17-,21-20-/t34-,38-,39-,40?,44-/m1/s1
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110042#_fe4ec9a8_207e_4b9d_b0b0_c103fb8ac977
initial concentration: NaN
boundary condition: true
is: SBO:0000252
name: ATP5J
is: Q6NZ59
constant: false
initial amount: NaN
has only substance units: false
is encoded by: hsa:522
type: Species

metaM ha deg1 l
has only substance units: false
is: SBO:0000247
initial amount: NaN
constant: false
is: CHEBI:16336
initial concentration: 1.0
name: hyaluronan degradation product 1
type: Species
boundary condition: false
notes: FORMULA: C22H33N2O16 CHARGE: -1

metaR r0641
modifier: MODEL1310110042#
reactant: MODEL1310110042#
reversible: true
is described by: ECO:0000000
name: (5-Glutamyl)-peptide:amino-acid 5-glutamyltransferase Arachidonic acid metabolism EC:2.3.2.2
product: MODEL1310110042#
notes: GENE_ASSOCIATION: (26275.1) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.2.2 Confidence Level: 0 AUTHORS: PMID:1968061 NOTES:
kinetic law: MODEL1310110042#
fast: false
type: Reaction
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.1.2.4

metaR APOCF
name: Apocarboxylase formation
product: MODEL1310110042#
notes: GENE_ASSOCIATION: SUBSYSTEM: Biotin metabolism EC Number: Confidence Level: 2 AUTHORS: PMID:10191093 NOTES:IT faked reaction to balance reaction in human biotin metabolism
type: Reaction
is: SBO:0000176
fast: false
kinetic law: MODEL1310110042#
reversible: false
reactant: MODEL1310110042#
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110042#_433cd25b_f011_4a85_9730_d437e8473a87
constant: false
has only substance units: false
is: P32119
is encoded by: hsa:7001
name: PRDX2
initial amount: NaN
type: Species
is: SBO:0000252
boundary condition: true
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110042#_8ce379df_c8b3_4e02_9213_57b65fd1fd14
type: Species
is: SBO:0000252
name: _AI090874_1_c
constant: false
initial concentration: NaN
is encoded by: hsa:AI090874
initial amount: NaN
boundary condition: true
has only substance units: false

metaR GHMT2r
is described by: ECO:0000269
fast: false
notes: GENE_ASSOCIATION: (6470.1) or (6470.2) SUBSYSTEM: Glycine, serine, alanine and threonine metabolism EC Number: 2.1.2.1 Confidence Level: 4 AUTHORS: PMID:8505317,PMID:8611185,PMID:9038835 NOTES:NCD
is: SBO:0000176
name: glycine hydroxymethyltransferase, reversible
modifier: MODEL1310110042#
product: MODEL1310110042#
kinetic law: MODEL1310110042#
reactant: MODEL1310110042#
reversible: true
type: Reaction
is version of: http://identifiers.org/ec-code/2.1.2.1

metaR ALADGLNexR
product: MODEL1310110042#
type: Reaction
name: L-alanine/glutamine reversible exchange
reactant: MODEL1310110042#
kinetic law: MODEL1310110042#
modifier: MODEL1310110042#
reversible: true
is described by: ECO:0000304
notes: GENE_ASSOCIATION: (56301.1) and (6520.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10734121,PMID:10863037,PMID:14770310 NOTES:
fast: false
is: SBO:0000185

metaM tddedicoa m
name: trans3,6dodecadienoylcoa
type: Species
notes: FORMULA: C33H50N7O17P3S CHARGE: -4
has only substance units: false
constant: false
initial amount: NaN
initial concentration: 1.0
is: http://identifiers.org/pubchem.compound/5280771
boundary condition: false
is: SBO:0000247

metaR S6T15g
is version of: http://identifiers.org/ec-code/2.8.2.21
notes: GENE_ASSOCIATION: (8534.1) or (9469.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: Confidence Level: 4 AUTHORS: PMID:12403612,PMID:8991509,PMID:9405439,PMID:9714738 NOTES:NCD
is version of: http://identifiers.org/ec-code/2.8.2.17
name: galactose/N-acetylglucosamine 6-O-sulfotransferase, Golgi apparatus
is: SBO:0000176
fast: false
kinetic law: MODEL1310110042#
product: MODEL1310110042#
reactant: MODEL1310110042#
is described by: ECO:0000000
modifier: MODEL1310110042#
type: Reaction
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110042#_4a237690_c41d_4db4_abe6_d04a55b68b01
type: Species
has only substance units: false
name: GALNT9
is: SBO:0000252
boundary condition: true
is: Q9HCQ5
initial amount: NaN
constant: false
initial concentration: NaN
is encoded by: hsa:50614

metaM o2 c
initial concentration: 1.0
type: Species
is: HMDB01377
has only substance units: false
notes: FORMULA: O2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00017 EHMN_ABBREVIATION: C00007
is: SBO:0000247
constant: false
is: CHEBI:15379
is: C00007
boundary condition: false
name: O2
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110042#_c146fb40_7dc3_4dd5_a2bf_c29cb24aad38
name: CYP1B1
initial concentration: NaN
has only substance units: false
is: Q16678
is encoded by: hsa:1545
type: Species
boundary condition: true
initial amount: NaN
is: SBO:0000252
constant: false

metaR DOLP Uter
notes: GENE_ASSOCIATION: SUBSYSTEM: N-glycan synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:12137737 NOTES:
kinetic law: MODEL1310110042#
is described by: ECO:0000000
product: MODEL1310110042#
reversible: false
name: dolichol phosphate flippase (uterus)
is: SBO:0000176
reactant: MODEL1310110042#
fast: false
type: Reaction

metaR RE3520E
is: SBO:0000176
modifier: MODEL1310110042#
notes: GENE_ASSOCIATION: (2880.1) or (257202.1) or (2882.1) or (2878.1) SUBSYSTEM: Arachidonic acid metabolism EC Number: 1.11.1.9 Confidence Level: 0 AUTHORS: PMID:10224163,PMID:2377602,PMID:3942774,PMID:9837935 NOTES:
fast: false
reactant: MODEL1310110042#
name: RE3520
product: MODEL1310110042#
reversible: true
kinetic law: MODEL1310110042#
type: Reaction
is version of: http://identifiers.org/ec-code/1.11.1.9
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110042#_513be926_16ba_42ff_a717_19fca235e7c8
initial concentration: NaN
boundary condition: true
initial amount: NaN
is: P05496
has only substance units: false
is encoded by: hsa:516
constant: false
type: Species
is: SBO:0000252
name: ATP5G1

metaR GALGLUSIDEtg
name: galgluside hs intracellular transport
type: Reaction
kinetic law: MODEL1310110042#
is described by: ECO:0000000
product: MODEL1310110042#
is: SBO:0000185
reversible: true
reactant: MODEL1310110042#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 1 AUTHORS: NOTES:unknown mechanism for transport - however must get to other intracellular compartments (e.g. lysosome for degradation) NJ

http://identifiers.org/biomodels.db/MODEL1310110042#_de259014_ca1b_4287_b68f_e61cb075417a
is: Q9H845
boundary condition: true
constant: false
initial amount: NaN
name: ACAD9
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:28976
has only substance units: false
type: Species

metaM ksii core2 l
has only substance units: false
notes: FORMULA: C81H129N6O67S3X CHARGE: -4
type: Species
boundary condition: false
name: keratan sulfate II (core 2-linked)
is: SBO:0000247
initial concentration: 1.0
is: HMDB01644
constant: false
is: CHEBI:17140
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110042#_7220361f_d053_4d81_9347_22e466726b2d
initial amount: NaN
type: Species
name: HYALP1
has only substance units: false
is encoded by: hsa:26062
is: SBO:0000252
constant: false
boundary condition: true
initial concentration: NaN

metaM ksii core2 deg9 l
has only substance units: false
notes: FORMULA: C30H50N3O20X CHARGE: 0
initial amount: NaN
type: Species
is: HMDB00143
name: keratan sulfate II (core 2-linked), degradation product 9
initial concentration: 1.0
is: CHEBI:12936
is: SBO:0000247
constant: false
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110042#_30b01c8c_c3d2_4d43_827c_7d7f5d617f1f
boundary condition: true
constant: false
is: SBO:0000252
has only substance units: false
is: O43451
initial concentration: NaN
is encoded by: hsa:8972
type: Species
name: MGAM
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110042#_3968b8b3_ed01_484c_9cdc_819ce00f55b0
initial amount: NaN
is: O95263
type: Species
name: PDE8B
is: SBO:0000252
initial concentration: NaN
boundary condition: true
has only substance units: false
constant: false
is encoded by: hsa:8622

metaR ACALDtm
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: PMID:9028626 NOTES:NCD
is described by: ECO:0000000
reactant: MODEL1310110042#
kinetic law: MODEL1310110042#
type: Reaction
name: acetaldehyde mitochondrial diffusion
product: MODEL1310110042#
reversible: true
fast: false

metaR EX CE5854 LPAREN e RPAREN
kinetic law: MODEL1310110042#
reactant: MODEL1310110042#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: gama-CEHC-glucuronide exchange
type: Reaction

metaM CE4794 m
constant: false
boundary condition: false
is: CHEBI:57923
initial amount: NaN
notes: FORMULA: C33H52N7O17P3S CHARGE: -4 INCHI: InChI=1/C33H56N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-24(42)61-17-16-35-23(41)14-15-36-31(45)28(44)33(2,3)19-54-60(51,52)57-59(49,50)53-18-22-27(56-58(46,47)48)26(43)32(55-22)40-21-39-25-29(34)37-20-38-30(25)40/h8-9,20-22,26-28,32,43-44H,4-7,10-19H2,1-3H3,(H,35,41)(H,36,45)(H,49,50)(H,51,52)(H2,34,37,38)(H2,46,47,48)/p-4/b9-8-/t22-,26+,27+,28u,32-/m0/s1 EHMN_ABBREVIATION: CE4794
has only substance units: false
is: SBO:0000247
type: Species
initial concentration: 1.0
name: cis-6-dodecenoyl-CoA

metaR CYSGLYexR
kinetic law: MODEL1310110042#
product: MODEL1310110042#
notes: GENE_ASSOCIATION: (6520.1) and (23428.1) or (6520.1) and (23428.2) or (56301.1) and (6520.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10734121,PMID:10863037,PMID:14770310 NOTES:Merged CYSGLYexR and CYSGLYex - (May 2011) IT
type: Reaction
name: L-cysteine/glycine reversible exchanger
reversible: true
fast: false
reactant: MODEL1310110042#
modifier: MODEL1310110042#
is described by: ECO:0000000
is: SBO:0000185

metaM icit x
initial amount: NaN
is: HMDB00193
type: Species
is: SBO:0000247
constant: false
is: CHEBI:16087
boundary condition: false
name: isocitrate(3-)
has only substance units: false
initial concentration: 1.0
notes: FORMULA: C6H5O7 CHARGE: -3 INCHI: InChI=1S/C6H8O7/c7-3(8)1-2(5(10)11)4(9)6(12)13/h2,4,9H,1H2,(H,7,8)(H,10,11)(H,12,13)/p-3 HEPATONET_1.0_ABBREVIATION: HC00266 EHMN_ABBREVIATION: C00311

http://identifiers.org/biomodels.db/MODEL1310110042#_48871e91_20e5_4d7d_985f_5d1910bdc146
boundary condition: true
is: SBO:0000252
is encoded by: hsa:10587
has only substance units: false
constant: false
type: Species
initial amount: NaN
initial concentration: NaN
name: TXNRD2

metaM 3mob m
is: HMDB00019
constant: false
name: 3-methyl-2-oxobutanoate
has only substance units: false
initial amount: NaN
is: SBO:0000247
boundary condition: false
notes: FORMULA: C5H7O3 CHARGE: -1 INCHI: InChI=1S/C5H8O3/c1-3(2)4(6)5(7)8/h3H,1-2H3,(H,7,8)/p-1 HEPATONET_1.0_ABBREVIATION: HC00139 EHMN_ABBREVIATION: C00141
initial concentration: 1.0
is: CHEBI:11851
type: Species

metaR ADK1m
modifier: MODEL1310110042#
reversible: true
reactant: MODEL1310110042#
is version of: http://identifiers.org/ec-code/2.7.4.3
fast: false
name: adenylate kinase, mitochondrial
kinetic law: MODEL1310110042#
type: Reaction
is: SBO:0000176
notes: GENE_ASSOCIATION: (205.3) or (205.1) or (204.1) or (204.3) or (204.2) or (205.2) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.3 Confidence Level: 4 AUTHORS: PMID:11485571,PMID:195572,PMID:8843353,PMID:9434148 NOTES:NCD
product: MODEL1310110042#
is described by: ECO:0000269

http://identifiers.org/biomodels.db/MODEL1310110042#_e840a6e1_1a93_4164_9223_d478f3dba347
constant: false
has only substance units: false
initial amount: NaN
boundary condition: true
type: Species
name: ACOX1
is: SBO:0000252
initial concentration: NaN
is encoded by: hsa:51
is: B4DK61

http://identifiers.org/biomodels.db/MODEL1310110042#_96cd5b27_4619_4071_b9b7_f1d636347bbf
initial amount: NaN
boundary condition: true
name: UGDH
has only substance units: false
is: O60701
type: Species
constant: false
is: SBO:0000252
is encoded by: hsa:7358
initial concentration: NaN

metaR SUCOASm
modifier: MODEL1310110042#
is version of: http://identifiers.org/ec-code/6.2.1.5
type: Reaction
reactant: MODEL1310110042#
notes: GENE_ASSOCIATION: (8802.1 and 8803.1) SUBSYSTEM: Citric acid cycle EC Number: 6.2.1.5 Confidence Level: 0 AUTHORS: PMID:9765291 NOTES:MIPS: cofactor ATP IF changed EC from 6.2.1.4 to 6.2.1.5 - NCD
product: MODEL1310110042#
fast: false
reversible: true
is version of: http://identifiers.org/ec-code/6.2.1.4
is: SBO:0000176
kinetic law: MODEL1310110042#
is described by: ECO:0000000
name: Succinate--CoA ligase (ADP-forming)

metaM dhap c
is: CHEBI:57642
initial amount: NaN
boundary condition: false
is: http://identifiers.org/pubchem.compound/3411
is: C00111
is: HMDB01473
has only substance units: false
type: Species
initial concentration: 1.0
constant: false
name: Dihydroxyacetone phosphate
is: SBO:0000247

metaR SUCCTD
kinetic law: MODEL1310110042#
product: MODEL1310110042#
reactant: MODEL1310110042#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: transport of succinate by diffusion
type: Reaction

metaM o2 e
name: O2
type: Species
initial concentration: 1.0
is: HMDB01377
notes: FORMULA: O2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00017 EHMN_ABBREVIATION: C00007
is: SBO:0000247
constant: false
has only substance units: false
is: C00007
initial amount: NaN
is: CHEBI:15379
boundary condition: false

metaR r0224
is described by: ECO:0000000
product: MODEL1310110042#
reversible: false
kinetic law: MODEL1310110042#
type: Reaction
fast: false
reactant: MODEL1310110042#
notes: GENE_ASSOCIATION: (6576.1) SUBSYSTEM: Folate metabolism EC Number: 1.5.1.3 Confidence Level: 0 AUTHORS: PMID:15153070,PMID:1631094,PMID:6882460 NOTES:
is: SBO:0000176
name: 5,6,7,8-Tetrahydrofolate:NAD+ oxidoreductase One carbon pool by folate EC:1.5.1.3
modifier: MODEL1310110042#

metaR r2099
type: Reaction
is: SBO:0000185
modifier: MODEL1310110042#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
reactant: MODEL1310110042#
reversible: true
kinetic law: MODEL1310110042#
product: MODEL1310110042#
fast: false
is described by: ECO:0000000
name: Major Facilitator(MFS) TCDB:2.A.1.13.1

metaR DPCOAtl
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 2 AUTHORS: PMID:6313022 NOTES:IT
type: Reaction
name: dephospho-CoA transport from lysosome via diffusion
product: MODEL1310110042#
is: SBO:0000185
fast: false
reactant: MODEL1310110042#
kinetic law: MODEL1310110042#
reversible: true

metaM lneldccoa m
is: SBO:0000247
has only substance units: false
is: http://identifiers.org/pubchem.compound/5462164
type: Species
name: linoelaidyl coenzyme A
boundary condition: false
initial amount: NaN
is: HMDB01064
initial concentration: 1.0
constant: false
notes: FORMULA: C39H62N7O17P3S CHARGE: -4

http://identifiers.org/biomodels.db/MODEL1310110042#_8e4c6077_dbe5_47bc_a971_1802fcb98ab8
type: Species
is encoded by: hsa:4715
is: Q9Y6M9
name: NDUFB9
constant: false
boundary condition: true
initial concentration: NaN
initial amount: NaN
is: SBO:0000252
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110042#_b148958e_da8e_45d3_8c89_f5791c95284c
boundary condition: true
constant: false
is: O60503
type: Species
initial concentration: NaN
is encoded by: hsa:115
is: SBO:0000252
has only substance units: false
initial amount: NaN
name: ADCY9

metaR PROSTGF2t
modifier: MODEL1310110042#
kinetic law: MODEL1310110042#
product: MODEL1310110042#
type: Reaction
notes: GENE_ASSOCIATION: (6582.2) or (6582.1) or (6580.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12827517,PMID:12883891,PMID:9187257 NOTES:electrogenic, Na indepdendent & rev NJ
reversible: true
name: prostaglandin uniport
is described by: ECO:0000269
reactant: MODEL1310110042#
fast: false
is: SBO:0000185

metaM succoa x
is: HMDB01022
boundary condition: false
constant: false
name: Succinyl-CoA
notes: FORMULA: C25H35N7O19P3S CHARGE: -5
type: Species
initial amount: NaN
initial concentration: 1.0
is: SBO:0000247
has only substance units: false

metaM cholcoa x
initial amount: NaN
initial concentration: 1.0
has only substance units: false
notes: FORMULA: C45H70N7O20P3S CHARGE: -4 INCHI: InChI=1S/C45H74N7O20P3S/c1-23(26-7-8-27-34-28(18-31(55)45(26,27)5)44(4)12-10-25(53)16-24(44)17-29(34)54)6-9-33(57)76-15-14-47-32(56)11-13-48-41(60)38(59)43(2,3)20-69-75(66,67)72-74(64,65)68-19-30-37(71-73(61,62)63)36(58)42(70-30)52-22-51-35-39(46)49-21-50-40(35)52/h21-31,34,36-38,42,53-55,58-59H,6-20H2,1-5H3,(H,47,56)(H,48,60)(H,64,65)(H,66,67)(H2,46,49,50)(H2,61,62,63)/p-4/t23-,24+,25-,26-,27+,28+,29-,30-,31+,34+,36-,37-,38+,42-,44+,45-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00844 EHMN_ABBREVIATION: C01794
constant: false
name: choloyl-CoA(4-)
is: SBO:0000247
is: CHEBI:57373
type: Species
is: HMDB01374
boundary condition: false

metaR GMPtn
reactant: MODEL1310110042#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: NOTES:IT
reversible: true
type: Reaction
is described by: ECO:0000000
product: MODEL1310110042#
name: GMP nuclear transport
kinetic law: MODEL1310110042#
is: SBO:0000185
fast: false

metaR GACPAILter
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:14517336 NOTES:NCD
is: SBO:0000185
type: Reaction
kinetic law: MODEL1310110042#
reversible: false
is described by: ECO:0000000
name: glucosaminyl-acylphosphatidylinositol ER flippase
reactant: MODEL1310110042#
product: MODEL1310110042#

http://identifiers.org/biomodels.db/MODEL1310110042#_47b08004_a64d_45c3_9695_a9e72fc08869
is: Q9HBH5
is encoded by: hsa:57665
constant: false
initial amount: NaN
type: Species
has only substance units: false
boundary condition: true
initial concentration: NaN
name: RDH14
is: SBO:0000252

metaR ELAIDt
name: fatty acid transport via diffusion
reversible: true
is described by: ECO:0000000
reactant: MODEL1310110042#
product: MODEL1310110042#
kinetic law: MODEL1310110042#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11788354,PMID:12864740 NOTES:NJ
type: Reaction
fast: false

metaR RE2987X
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (3295.1) or (1962.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.1.1.35 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:10970790,PMID:7775433 NOTES:
reactant: MODEL1310110042#
modifier: MODEL1310110042#
fast: false
is version of: http://identifiers.org/ec-code/4.2.1.107
reversible: true
name: RE2987
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.1.1.35
type: Reaction
kinetic law: MODEL1310110042#
product: MODEL1310110042#

metaR ACCOAC
kinetic law: MODEL1310110042#
product: MODEL1310110042#
reactant: MODEL1310110042#
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: false
name: acetyl-CoA carboxylase
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110042#_b5325491_df90_4b84_acbd_46d1286e0a9f
initial concentration: NaN
is: Q8NFW8
name: CMAS
constant: false
has only substance units: false
boundary condition: true
initial amount: NaN
is encoded by: hsa:55907
is: SBO:0000252
type: Species

metaR GLYK
modifier: MODEL1310110042#
name: glycerol kinase
product: MODEL1310110042#
reversible: false
fast: false
kinetic law: MODEL1310110042#
is version of: http://identifiers.org/ec-code/2.7.1.30
is: SBO:0000176
is described by: ECO:0000269
reactant: MODEL1310110042#
notes: GENE_ASSOCIATION: (2710.2) or (2712.1) or (2710.1) or (2713.1) SUBSYSTEM: Glycerophospholipid metabolism EC Number: Confidence Level: 4 AUTHORS: NOTES:
type: Reaction

metaR r0437
modifier: MODEL1310110042#
type: Reaction
kinetic law: MODEL1310110042#
is described by: ECO:0000000
name: Palmitoyl-CoA:L-carnitine O-palmitoyltransferase Fatty acid metabolism EC:2.3.1.21
is: SBO:0000176
fast: false
reversible: true
notes: GENE_ASSOCIATION: (AI469183.1) or (226.1) or (229.1) or (230.1) or (BC005314.1) or (BF195998.1) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.21 Confidence Level: 0 AUTHORS: PMID:1735445,PMID:1988962,PMID:2355017,PMID:6361812,PMID:7892212 NOTES:
is version of: http://identifiers.org/ec-code/4.1.2.13
reactant: MODEL1310110042#
product: MODEL1310110042#

metaM HC02217 e
boundary condition: false
initial concentration: 1.0
initial amount: NaN
is: CHEBI:27647
type: Species
name: prostaglandin-g2
constant: false
notes: FORMULA: C20H31O6 CHARGE: -1 INCHI: InChI=1S/C20H32O6/c1-2-3-6-9-15(24-23)12-13-17-16(18-14-19(17)26-25-18)10-7-4-5-8-11-20(21)22/h4,7,12-13,15-19,23H,2-3,5-6,8-11,14H2,1H3,(H,21,22)/b7-4-,13-12+/t15-,16+,17+,18-,19+/m0/s1 EHMN_ABBREVIATION: C05956
has only substance units: false
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110042#_2fbcb472_9429_4167_a976_5829f7902075
is encoded by: hsa:2880
name: GPX5
constant: false
type: Species
initial concentration: NaN
initial amount: NaN
is: O75715
is: SBO:0000252
boundary condition: true
has only substance units: false

metaR EX 7thf LPAREN e RPAREN
kinetic law: MODEL1310110042#
reactant: MODEL1310110042#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: heptaglutamyl folate (THF) exchange
type: Reaction

metaR HPCLx
type: Reaction
name: 2-hydroxyphytanoyl-CoA lyase
is: SBO:0000176
modifier: MODEL1310110042#
kinetic law: MODEL1310110042#
reversible: false
product: MODEL1310110042#
fast: false
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (26062.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: PMID:10468558 NOTES:pristanal is the fatty aldehyde analog of pristanic acid Catalyzes a carbon-carbon cleavage reaction; cleaves a 2-hydroxy-3-methylacyl-CoA into formyl-CoA and a 2-methyl-branched fatty aldehyde. NJ
reactant: MODEL1310110042#

http://identifiers.org/biomodels.db/MODEL1310110042#_f0006fff_57fb_4660_8119_13fb22e03b4b
boundary condition: true
type: Species
constant: false
is: SBO:0000252
is: Q9BVK2
name: ALG8
initial concentration: NaN
has only substance units: false
initial amount: NaN
is encoded by: hsa:79053

metaM dhap e
is: SBO:0000247
is: CHEBI:57642
initial concentration: 1.0
notes: FORMULA: C3H5O6P CHARGE: -2 INCHI: InChI=1S/C3H7O6P/c4-1-3(5)2-9-10(6,7)8/h4H,1-2H2,(H2,6,7,8)/p-2 HEPATONET_1.0_ABBREVIATION: HC00109 EHMN_ABBREVIATION: C00111
name: glycerone phosphate(2-)
boundary condition: false
is: HMDB01473
type: Species
constant: false
has only substance units: false
initial amount: NaN

metaR C140CPT1
kinetic law: MODEL1310110042#
product: MODEL1310110042#
reactant: MODEL1310110042#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: production of myristoylcarnitine
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110042#_6371a568_3598_445b_9dbc_b3f1fc2334b9
is encoded by: hsa:765
initial concentration: NaN
initial amount: NaN
name: CA6
type: Species
is: Q5FC00
has only substance units: false
boundary condition: true
constant: false
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110042#_d030d265_75cb_41b1_9cef_cd6a2541d387
initial amount: NaN
constant: false
is encoded by: hsa:54965
type: Species
is: SBO:0000252
has only substance units: false
name: PIGX
initial concentration: NaN
boundary condition: true
is: Q8TBF5

http://identifiers.org/biomodels.db/MODEL1310110042#_54617c5c_59ee_46b4_8fe3_207202f1ec83
constant: false
is: SBO:0000252
initial concentration: NaN
has only substance units: false
type: Species
name: ATP2B3
boundary condition: true
is: Q16720
initial amount: NaN
is encoded by: hsa:492

metaR PHYHx
reactant: MODEL1310110042#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.14.11.18
notes: GENE_ASSOCIATION: (5264.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.14.11.18 Confidence Level: 4 AUTHORS: PMID:8954107,PMID:9326940 NOTES:NJ
kinetic law: MODEL1310110042#
reversible: false
modifier: MODEL1310110042#
type: Reaction
product: MODEL1310110042#
fast: false
name: Phytanoyl-CoA dioxygenase, peroxisomal
is described by: ECO:0000269

metaR r2097
fast: false
modifier: MODEL1310110042#
product: MODEL1310110042#
is: SBO:0000185
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
reversible: true
reactant: MODEL1310110042#
kinetic law: MODEL1310110042#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110042#_2f80bd21_3894_441c_a479_554d150e3df2
has only substance units: false
initial concentration: NaN
is: SBO:0000252
boundary condition: true
is encoded by: hsa:3242
name: HPD
is: B3KQ63
initial amount: NaN
type: Species
constant: false

metaR RE2799C
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Eicosanoid metabolism EC Number: 1.1.1.188 Confidence Level: 0 AUTHORS: PMID:12543809,PMID:7948008 NOTES:
product: MODEL1310110042#
name: RE2799
is described by: ECO:0000000
is: SBO:0000176
reversible: true
kinetic law: MODEL1310110042#
reactant: MODEL1310110042#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110042#_bef8dd24_02d6_4c77_a211_33767e91afeb
is encoded by: hsa:81579
is: SBO:0000252
boundary condition: true
name: PLA2G12A
type: Species
initial amount: NaN
initial concentration: NaN
constant: false
is: Q542Y6
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110042#_cbf69afb_cc85_48e7_beaf_e4a95063bc99
is encoded by: hsa:54898
initial concentration: NaN
is: Q9NXB9
boundary condition: true
is: SBO:0000252
has only substance units: false
initial amount: NaN
constant: false
type: Species
name: ELOVL2

metaR SERGLNexR
name: L-Serine/Glutamine reversible exchange
product: MODEL1310110042#
notes: GENE_ASSOCIATION: (56301.1) and (6520.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10734121,PMID:10863037,PMID:14770310 NOTES:
reactant: MODEL1310110042#
kinetic law: MODEL1310110042#
modifier: MODEL1310110042#
is described by: ECO:0000304
type: Reaction
reversible: true
fast: false
is: SBO:0000185

metaM HC02217 c
notes: FORMULA: C20H31O6 CHARGE: -1 INCHI: InChI=1S/C20H32O6/c1-2-3-6-9-15(24-23)12-13-17-16(18-14-19(17)26-25-18)10-7-4-5-8-11-20(21)22/h4,7,12-13,15-19,23H,2-3,5-6,8-11,14H2,1H3,(H,21,22)/b7-4-,13-12+/t15-,16+,17+,18-,19+/m0/s1 EHMN_ABBREVIATION: C05956
boundary condition: false
type: Species
has only substance units: false
constant: false
initial amount: NaN
is: SBO:0000247
is: CHEBI:27647
name: prostaglandin-g2
initial concentration: 1.0

metaM 10fthf c
is: SBO:0000247
constant: false
initial concentration: 1.0
boundary condition: false
is: HMDB00972
is: C00234
name: 10-Formyltetrahydrofolate
type: Species
notes: FORMULA: C20H21N7O7 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00212 EHMN_ABBREVIATION: C00234
initial amount: NaN
is: CHEBI:57454
has only substance units: false

metaM core3 g
boundary condition: false
name: Core 3
has only substance units: false
is: CHEBI:16250
notes: FORMULA: C16H27N2O10X CHARGE: 0
constant: false
initial amount: NaN
initial concentration: 1.0
is: SBO:0000247
type: Species

http://identifiers.org/biomodels.db/MODEL1310110042#_1630e290_edcb_4ae5_b544_4dfa43db468a
is: SBO:0000252
type: Species
boundary condition: true
initial concentration: NaN
initial amount: NaN
name: IDH3B
has only substance units: false
constant: false
is encoded by: hsa:3420

metaR TYMSULT
kinetic law: MODEL1310110042#
is described by: ECO:0000269
product: MODEL1310110042#
reversible: false
is version of: http://identifiers.org/ec-code/2.8.2.1
fast: false
reactant: MODEL1310110042#
is: SBO:0000176
modifier: MODEL1310110042#
notes: GENE_ASSOCIATION: (6818.3) or (6818.1) or (6817.4) or (6817.1) or (6817.3) or (6818.2) or (6817.2) or (6817.5) SUBSYSTEM: Tyrosine metabolism EC Number: 2.8.2.1 Confidence Level: 4 AUTHORS: PMID:11535246,PMID:15293241 NOTES:TV/RS (6/14/05)
name: Tyramine Sulfotransferase
type: Reaction

metaR r2098
product: MODEL1310110042#
type: Reaction
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
fast: false
kinetic law: MODEL1310110042#
modifier: MODEL1310110042#
reversible: true
is described by: ECO:0000000
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
reactant: MODEL1310110042#
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110042#_bae1e305_0cfd_4c97_a1bf_8a77b268ab2d
is encoded by: hsa:203
type: Species
has only substance units: false
initial concentration: NaN
is: P00568
initial amount: NaN
boundary condition: true
is: SBO:0000252
constant: false
name: AK1

metaM thmpp m
initial concentration: 1.0
name: Thiamine diphosphate
is: HMDB01372
has only substance units: false
type: Species
notes: FORMULA: C12H16N4O7P2S CHARGE: -2 INCHI: InChI=1S/C12H18N4O7P2S/c1-8-11(3-4-22-25(20,21)23-24(17,18)19)26-7-16(8)6-10-5-14-9(2)15-12(10)13/h5,7H,3-4,6H2,1-2H3,(H4-,13,14,15,17,18,19,20,21) HEPATONET_1.0_ABBREVIATION: HC00071 EHMN_ABBREVIATION: C00068
constant: false
initial amount: NaN
is: SBO:0000247
is: CHEBI:45931
boundary condition: false

metaM ksi deg23 l
name: keratan sulfate I, degradation product 23
is: HMDB00143
is: SBO:0000247
initial amount: NaN
has only substance units: false
notes: FORMULA: C124H201N8O106S5 CHARGE: -5
is: CHEBI:12936
boundary condition: false
initial concentration: 1.0
type: Species
constant: false

metaM ksii core2 g
constant: false
is: CHEBI:17140
boundary condition: false
initial concentration: 1.0
type: Species
name: keratan sulfate II (core 2-linked)
has only substance units: false
is: HMDB01644
notes: FORMULA: C81H129N6O67S3X CHARGE: -4
is: SBO:0000247
initial amount: NaN

metaM c4dc c
initial amount: NaN
is: C02862
constant: false
has only substance units: false
is: http://identifiers.org/pubchem.compound/213144
is: SBO:0000247
initial concentration: 1.0
boundary condition: false
is: HMDB02013
name: succinyl carnitine
type: Species
notes: FORMULA: C11H18NO6 CHARGE: -1

http://identifiers.org/biomodels.db/MODEL1310110042#_f69789b7_88a1_45b7_834c_689b5e1edf0d
initial amount: NaN
constant: false
type: Species
is: SBO:0000252
initial concentration: NaN
boundary condition: true
has only substance units: false
is: P04181
name: OAT
is encoded by: hsa:4942

metaR ASNtN1
modifier: MODEL1310110042#
name: Asparagine transport (Na, H coupled)
is described by: ECO:0000269
fast: false
is: SBO:0000185
product: MODEL1310110042#
reactant: MODEL1310110042#
kinetic law: MODEL1310110042#
notes: GENE_ASSOCIATION: (92745.1) or (10991.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10823827,PMID:12845534 NOTES:SAB based om PMID 10823827
reversible: true
type: Reaction

metaM ksi pre23 g
constant: false
initial concentration: 1.0
initial amount: NaN
is: SBO:0000247
name: keratan sulfate I biosynthesis, precursor 23
is: CHEBI:28067
has only substance units: false
notes: FORMULA: C185H296N13O153S7X CHARGE: -8
type: Species
boundary condition: false

metaM dmhptcoa m
notes: FORMULA: C30H52N7O17P3S CHARGE: -4 INCHI: InChI=1/C30H52N7O17P3S/c1-17(2)7-6-8-18(3)29(42)58-12-11-32-20(38)9-10-33-27(41)24(40)30(4,5)14-51-57(48,49)54-56(46,47)50-13-19-23(53-55(43,44)45)22(39)28(52-19)37-16-36-21-25(31)34-15-35-26(21)37/h15-19,22-24,28,39-40H,6-14H2,1-5H3,(H,32,38)(H,33,41)(H,46,47)(H,48,49)(H2,31,34,35)(H2,43,44,45)/p-4/t18-,19+,22-,23-,24?,28+/m0/s1
is: SBO:0000247
has only substance units: false
initial amount: NaN
name: 2,6 dimethylheptanoyl-CoA
boundary condition: false
is: HMDB06258
type: Species
constant: false
initial concentration: 1.0

metaM cholp c
type: Species
boundary condition: false
has only substance units: false
initial concentration: 1.0
notes: FORMULA: C5H13NO4P CHARGE: -1 INCHI: InChI=1S/C5H14NO4P/c1-6(2,3)4-5-10-11(7,8)9/h4-5H2,1-3H3,(H-,7,8,9)/p-1 HEPATONET_1.0_ABBREVIATION: HC00442 EHMN_ABBREVIATION: C00588
constant: false
is: CHEBI:295975
initial amount: NaN
is: SBO:0000247
name: choline phosphate(1-)

metaR r2095
modifier: MODEL1310110042#
type: Reaction
product: MODEL1310110042#
fast: false
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
is: SBO:0000185
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
reversible: true
kinetic law: MODEL1310110042#
is described by: ECO:0000000
reactant: MODEL1310110042#

metaR RE2626M
product: MODEL1310110042#
modifier: MODEL1310110042#
type: Reaction
notes: GENE_ASSOCIATION: (1593.1) SUBSYSTEM: Bile acid synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:9210654,PMID:9660774 NOTES:
kinetic law: MODEL1310110042#
is version of: http://identifiers.org/ec-code/1.14.13.15
name: RE2626
reactant: MODEL1310110042#
reversible: true
is: SBO:0000176
fast: false
is described by: ECO:0000000

metaR FATP2t
modifier: MODEL1310110042#
notes: GENE_ASSOCIATION: (376497.1) or (376497.2) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12856180,PMID:15522816 NOTES:electroneutral transport NJ
type: Reaction
is described by: ECO:0000269
kinetic law: MODEL1310110042#
name: fatty acid electroneutral transport
fast: false
reversible: true
product: MODEL1310110042#
reactant: MODEL1310110042#
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110042#_d3fa0297_4775_47a5_9841_13b1ae6265e9
initial amount: NaN
is: SBO:0000252
is encoded by: hsa:100287639
boundary condition: true
type: Species
name: _100287639_1_c
has only substance units: false
initial concentration: NaN
constant: false

metaR FAOXC165C164x
kinetic law: MODEL1310110042#
product: MODEL1310110042#
reactant: MODEL1310110042#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C16:5-->C16:4)x
type: Reaction

metaR GALGLUSIDEtl
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 1 AUTHORS: NOTES:unknown mechanism for transport - however must get to other intracellular compartments (e.g. lysosome for degradation) NJ
type: Reaction
is described by: ECO:0000000
product: MODEL1310110042#
reactant: MODEL1310110042#
reversible: true
name: galgluside hs intracellular transport
is: SBO:0000185
fast: false
kinetic law: MODEL1310110042#

metaR EX 5oxpro LPAREN e RPAREN
kinetic law: MODEL1310110042#
reactant: MODEL1310110042#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: Exchange of 5-oxoprolinate
type: Reaction

metaR r2096
reversible: true
product: MODEL1310110042#
is: SBO:0000185
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
type: Reaction
modifier: MODEL1310110042#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
reactant: MODEL1310110042#
kinetic law: MODEL1310110042#
fast: false
is described by: ECO:0000000

metaR S6TASE8ly
is version of: http://identifiers.org/ec-code/3.2.1.18
type: Reaction
product: MODEL1310110042#
fast: false
modifier: MODEL1310110042#
is version of: http://identifiers.org/ec-code/3.2.1.23
reversible: true
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.1.6.4
is described by: ECO:0000000
kinetic law: MODEL1310110042#
name: N-acetylgalactosamine-6-sulfatase, lysosomal
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) SUBSYSTEM: Chondroitin sulfate degradation EC Number: 3.1.6.4 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD
reactant: MODEL1310110042#
is version of: http://identifiers.org/ec-code/3.4.16.5

metaR EX 4mptnl LPAREN e RPAREN
kinetic law: MODEL1310110042#
reactant: MODEL1310110042#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 4-methylpentanal Exchange
type: Reaction

metaR MTHFCm
reactant: MODEL1310110042#
is: SBO:0000176
modifier: MODEL1310110042#
is version of: http://identifiers.org/ec-code/6.3.4.3
name: methenyltetrahydrifikate cyclohydrolase, mitochondrial
fast: false
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (25902.1) or (10797.1) SUBSYSTEM: Folate metabolism EC Number: 3.5.4.9 Confidence Level: 4 AUTHORS: PMID:12937168 NOTES:NCD
product: MODEL1310110042#
reversible: true
is version of: http://identifiers.org/ec-code/3.5.4.9
kinetic law: MODEL1310110042#
type: Reaction

metaR HDECEACBP
kinetic law: MODEL1310110042#
product: MODEL1310110042#
reactant: MODEL1310110042#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: transport of 3-hydroxyhexadecenoylcoa from mitochondria into the cytosol
type: Reaction

metaR PItg
kinetic law: MODEL1310110042#
name: phosphate transport, Golgi apparatus
reversible: false
is described by: ECO:0000000
product: MODEL1310110042#
type: Reaction
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 2 AUTHORS: NOTES:NCD
reactant: MODEL1310110042#
fast: false

metaR GALASE11ly
is version of: http://identifiers.org/ec-code/3.2.1.23
is: SBO:0000176
reactant: MODEL1310110042#
modifier: MODEL1310110042#
is version of: http://identifiers.org/ec-code/3.2.1.18
reversible: false
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/3.4.16.5
fast: false
kinetic law: MODEL1310110042#
name: beta-galactosidase, lysosomal
type: Reaction
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) or (5476.1) and (2720.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.23 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD
product: MODEL1310110042#
is version of: http://identifiers.org/ec-code/3.1.6.4

metaR AKR1D
is version of: http://identifiers.org/ec-code/1.3.1.3
kinetic law: MODEL1310110042#
is described by: ECO:0000269
product: MODEL1310110042#
is: SBO:0000176
modifier: MODEL1310110042#
fast: false
name: aldo-keto reductase family 1, member D1 (delta 4-3-ketosteroid-5-beta-reductase)
type: Reaction
notes: GENE_ASSOCIATION: (6718.1) SUBSYSTEM: Bile acid synthesis EC Number: 1.3.99.6 Confidence Level: 4 AUTHORS: NOTES:refs: uniprot, KEGG DW Russell bile acid synthesis review paper (see human recon journal citations) NJ
reversible: false
reactant: MODEL1310110042#

metaM cs a deg4 l
initial concentration: 1.0
is: SBO:0000247
type: Species
initial amount: NaN
constant: false
has only substance units: false
boundary condition: false
notes: FORMULA: C31H49NO29S CHARGE: -2
is: HMDB00812
name: chondroitin sulfate A (GalNAc4S-GlcA), degradation product 4
is: CHEBI:16953

metaR ACACT7p
is version of: http://identifiers.org/ec-code/2.3.1.16
reversible: false
is described by: ECO:0000269
type: Reaction
notes: GENE_ASSOCIATION: (30.1) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.16 Confidence Level: 4 AUTHORS: PMID:1679347 NOTES:NCD
kinetic law: MODEL1310110042#
reactant: MODEL1310110042#
modifier: MODEL1310110042#
is: SBO:0000176
fast: false
name: acetyl-CoA acyltransferase (tetradecanoyl-CoA), peroxisomal
product: MODEL1310110042#

metaR THBPT4ACAMDASE
fast: false
reactant: MODEL1310110042#
is version of: http://identifiers.org/ec-code/4.2.1.96
product: MODEL1310110042#
is: SBO:0000176
kinetic law: MODEL1310110042#
is described by: ECO:0000269
modifier: MODEL1310110042#
reversible: false
name: Tetrahydrobiopterin-4a-carbinolamine dehydratase
type: Reaction
notes: GENE_ASSOCIATION: (5092.1) or (5092.2) SUBSYSTEM: Tetrahydrobiopterin metabolism EC Number: 4.2.1.96 Confidence Level: 4 AUTHORS: PMID:10727395 NOTES:SAB based on PMID 10727395

metaR BTNPL
modifier: MODEL1310110042#
is described by: ECO:0000000
is: SBO:0000176
name: holocarboxylase synthestase (biotin protein ligase)
type: Reaction
is version of: http://identifiers.org/ec-code/6.3.4.10
reversible: false
reactant: MODEL1310110042#
notes: GENE_ASSOCIATION: (3141.1) SUBSYSTEM: Biotin metabolism EC Number: Confidence Level: 4 AUTHORS: NOTES:IT for human biotin metabolism
kinetic law: MODEL1310110042#
product: MODEL1310110042#
fast: false

metaM 3hexdcoa c
is: HMDB03932
constant: false
boundary condition: false
initial concentration: 1.0
initial amount: NaN
type: Species
has only substance units: false
notes: FORMULA: C37H62N7O18P3S CHARGE: -4
name: 3-hydroxyhexadecanoylcoa
is: SBO:0000247
is: C05258

metaR SUCOAS1m
reversible: true
name: Succinate--CoA ligase (GDP-forming)
product: MODEL1310110042#
fast: false
is: SBO:0000176
notes: GENE_ASSOCIATION: (8802.1 and 8801.1) SUBSYSTEM: Citric acid cycle EC Number: 6.2.1.4 Confidence Level: 0 AUTHORS: PMID:9765291 NOTES:IF
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/6.2.1.4
type: Reaction
modifier: MODEL1310110042#
kinetic law: MODEL1310110042#
reactant: MODEL1310110042#

http://identifiers.org/biomodels.db/MODEL1310110042#_7b1bb9b2_46f2_4790_b560_d615a02cfc30
boundary condition: true
has only substance units: false
initial concentration: NaN
constant: false
is: A7E2E0
is encoded by: hsa:5293
is: SBO:0000252
name: PIK3CD
initial amount: NaN
type: Species

http://identifiers.org/biomodels.db/MODEL1310110042#_34e53951_6896_4e89_80da_6c47c3ac07d1
boundary condition: true
is encoded by: hsa:4709
constant: false
initial concentration: NaN
is: SBO:0000252
is: Q6IB80
name: NDUFB3
has only substance units: false
type: Species
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110042#_32779412_0b0c_493e_bd1b_682bf96fa442
initial amount: NaN
name: FTCD
type: Species
constant: false
boundary condition: true
is encoded by: hsa:10841
is: SBO:0000252
initial concentration: NaN
has only substance units: false

metaR C4OHc
kinetic law: MODEL1310110042#
product: MODEL1310110042#
reactant: MODEL1310110042#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: production of 3-hydroxybytyryl carnitinec
type: Reaction

metaR EX CE5869 LPAREN e RPAREN
kinetic law: MODEL1310110042#
reactant: MODEL1310110042#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: lysyl-proline exchange
type: Reaction

metaR LNLNCGCPT1
reversible: false
is version of: http://identifiers.org/ec-code/2.3.1.21
type: Reaction
fast: false
is described by: ECO:0000269
product: MODEL1310110042#
modifier: MODEL1310110042#
is: SBO:0000176
kinetic law: MODEL1310110042#
reactant: MODEL1310110042#
notes: GENE_ASSOCIATION: (1375.1) or (1375.3) or (1375.4) or (126129.1) or (1374.1) or (1375.2) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.21 Confidence Level: 4 AUTHORS: NOTES:NJ
name: carnitine O-palmitoyltransferase

metaR FAOXC226
is: SBO:0000176
modifier: MODEL1310110042#
name: Beta oxidation of long chain fatty acid
is described by: ECO:0000000
fast: false
reactant: MODEL1310110042#
product: MODEL1310110042#
reversible: false
kinetic law: MODEL1310110042#
is version of: http://identifiers.org/ec-code/1.3.99.3
is version of: http://identifiers.org/ec-code/1.3.8.1
type: Reaction
notes: GENE_ASSOCIATION: (35.1) or (34.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.99.3 Confidence Level: 4 AUTHORS: PMID:2565344,PMID:3035565 NOTES:TV Other enzymes: 1.3.3.6, 4.2.1.74, 4.2.1.17, 1.1.1.35, 1.1.1.211

metaM 3decdicoa m
initial amount: NaN
is: SBO:0000247
notes: FORMULA: C31H46N7O17P3S CHARGE: -4
boundary condition: false
is: http://identifiers.org/pubchem.compound/16019966
initial concentration: 1.0
name: 3,7-decadienoylcoa
has only substance units: false
type: Species
constant: false

metaR GLCNACASE2ly
notes: GENE_ASSOCIATION: (4669.1) SUBSYSTEM: Heparan sulfate degradation EC Number: 3.2.1.50 Confidence Level: 4 AUTHORS: PMID:1783617,PMID:8776591,PMID:8993162 NOTES:NCD
is described by: ECO:0000000
fast: false
modifier: MODEL1310110042#
reactant: MODEL1310110042#
type: Reaction
product: MODEL1310110042#
is: SBO:0000176
kinetic law: MODEL1310110042#
is version of: http://identifiers.org/ec-code/3.2.1.50
name: alpha-N-acetylglucosaminidase, lysosomal
reversible: false

metaR EX ura LPAREN e RPAREN
kinetic law: MODEL1310110042#
reactant: MODEL1310110042#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Uracil exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110042#_14eb798b_4ed1_4431_81e1_fd3392974bc2
has only substance units: false
is: SBO:0000252
is encoded by: hsa:AI653169
name: _AI653169_1_c
initial amount: NaN
constant: false
initial concentration: NaN
boundary condition: true
type: Species

metaM 3mob e
has only substance units: false
notes: FORMULA: C5H7O3 CHARGE: -1 INCHI: InChI=1S/C5H8O3/c1-3(2)4(6)5(7)8/h3H,1-2H3,(H,7,8)/p-1
constant: false
initial concentration: 1.0
is: HMDB00019
initial amount: NaN
boundary condition: false
is: CHEBI:11851
type: Species
name: 3-methyl-2-oxobutanoate
is: SBO:0000247

metaM ksi deg1 e
type: Species
is: CHEBI:17268
is: SBO:0000247
initial concentration: 1.0
notes: FORMULA: C241H383N17O209S12X CHARGE: -13
has only substance units: false
is: HMDB00211
initial amount: NaN
constant: false
name: keratan sulfate I, degradation product 1
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110042#_0bdfa185_4d66_43a5_a4b8_4b9fd1faaf2c
constant: false
type: Species
name: TK2
initial concentration: NaN
boundary condition: true
is: O00142
is encoded by: hsa:7084
initial amount: NaN
is: SBO:0000252
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110042#_84ff39a1_f097_45e5_9f99_0a4cd5f3f03f
is: Q9UGH3
boundary condition: true
initial amount: NaN
has only substance units: false
is: SBO:0000252
name: SLC23A2
initial concentration: NaN
is encoded by: hsa:9962
constant: false
type: Species

metaR LEULEULAPc
kinetic law: MODEL1310110042#
product: MODEL1310110042#
reactant: MODEL1310110042#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: hydrolysis of Leucylleucine in the small intestine for cellular uptake
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110042#_0712a9a4_1ce1_4ba3_85bc_f35a1b228b1e
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:85365
type: Species
initial amount: NaN
constant: false
name: ALG2
has only substance units: false
boundary condition: true

metaR r1925
modifier: MODEL1310110042#
kinetic law: MODEL1310110042#
name: Y+LAT2 Utilized transport
product: MODEL1310110042#
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is described by: ECO:0000000
is: SBO:0000185
reactant: MODEL1310110042#
fast: false
reversible: false
type: Reaction

metaR PAIL HStn
reactant: MODEL1310110042#
type: Reaction
name: phosphatidylinositol nuclear transport (diffusion)
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 1 AUTHORS: NOTES:
product: MODEL1310110042#
fast: false
is: SBO:0000185
kinetic law: MODEL1310110042#
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110042#_d61ac00a_e371_4aa3_8dd9_df1f97353a28
initial amount: NaN
boundary condition: true
is: SBO:0000252
is encoded by: hsa:27068
is: F8WDN9
type: Species
name: PPA2
has only substance units: false
constant: false
initial concentration: NaN

metaR LEUKTRE4t
reversible: true
reactant: MODEL1310110042#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:
kinetic law: MODEL1310110042#
is described by: ECO:0000000
product: MODEL1310110042#
is: SBO:0000185
type: Reaction
name: leukotriene E4 transport
fast: false

http://identifiers.org/biomodels.db/MODEL1310110042#_655d64de_c63f_40fc_8714_02623409af09
initial amount: NaN
type: Species
is: P04183
has only substance units: false
name: TK1
boundary condition: true
initial concentration: NaN
constant: false
is encoded by: hsa:7083
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110042#_dde3b0a7_83c4_4406_b486_6d3f03159001
type: Species
name: _AI620219_1_c
constant: false
has only substance units: false
boundary condition: true
is: SBO:0000252
is encoded by: hsa:AI620219
initial concentration: NaN
initial amount: NaN

metaR r0441
reversible: true
product: MODEL1310110042#
fast: false
kinetic law: MODEL1310110042#
is version of: http://identifiers.org/ec-code/2.7.1.40
name: Palmitoyl-CoA:L-carnitine O-palmitoyltransferase Fatty acid metabolism EC:2.3.1.21
type: Reaction
is described by: ECO:0000000
modifier: MODEL1310110042#
is: SBO:0000176
notes: GENE_ASSOCIATION: (H77542.1) or (5313.1) or (5315.1) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.21 Confidence Level: 0 AUTHORS: PMID:1735445,PMID:1988962,PMID:2355017,PMID:6361812,PMID:7892212 NOTES:
reactant: MODEL1310110042#

metaR LNLNCGCPT2
notes: GENE_ASSOCIATION: (1376.1) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.21 Confidence Level: 4 AUTHORS: NOTES:NJ
modifier: MODEL1310110042#
kinetic law: MODEL1310110042#
product: MODEL1310110042#
name: carnitine transferase
type: Reaction
fast: false
reversible: false
is described by: ECO:0000269
reactant: MODEL1310110042#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.3.1.21

metaR DRIBt
type: Reaction
is: SBO:0000185
product: MODEL1310110042#
fast: false
name: deoxyribose transport via diffusion
reactant: MODEL1310110042#
is described by: ECO:0000000
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:9693094 NOTES:NCD
kinetic law: MODEL1310110042#

metaR ASNPHELAT2tc
kinetic law: MODEL1310110042#
product: MODEL1310110042#
reactant: MODEL1310110042#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of L-Asparagine into the cell and efflux of L-Phenylalanine out of the cell by LAT2 on the basolateral surfaces of kidney and intestine.
type: Reaction

metaM tetpent6coa x
notes: FORMULA: C45H68N7O17P3S CHARGE: -4 INCHI: InChI=1/C45H72N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-24-25-36(54)73-29-28-47-35(53)26-27-48-43(57)40(56)45(2,3)31-66-72(63,64)69-71(61,62)65-30-34-39(68-70(58,59)60)38(55)44(67-34)52-33-51-37-41(46)49-32-50-42(37)52/h8-9,11-12,14-15,17-18,20-21,32-34,38-40,44,55-56H,4-7,10,13,16,19,22-31H2,1-3H3,(H,47,53)(H,48,57)(H,61,62)(H,63,64)(H2,46,49,50)(H2,58,59,60)/b9-8-,12-11-,15-14-,18-17-,21-20-/t34-,38-,39-,40?,44-/m1/s1
initial amount: NaN
has only substance units: false
constant: false
type: Species
name: tetracosapentaenoyl coenzyme A, n-6
boundary condition: false
initial concentration: 1.0
is: SBO:0000247
is: C16172

metaR RDH1a
reversible: true
modifier: MODEL1310110042#
product: MODEL1310110042#
is described by: ECO:0000269
type: Reaction
fast: false
is version of: http://identifiers.org/ec-code/1.1.1.300
reactant: MODEL1310110042#
kinetic law: MODEL1310110042#
notes: GENE_ASSOCIATION: (157506.1) or (112724.1) or (145226.1) or (51109.1) or (195814.1) or (57665.1) or (50700.1) SUBSYSTEM: Vitamin A metabolism EC Number: 1.1.1.105 Confidence Level: 4 AUTHORS: PMID:12226107,PMID:12372410,PMID:12407145,PMID:1503811,PMID:15258582,PMID:15322982 NOTES:IT
is version of: http://identifiers.org/ec-code/1.1.1.105
name: retinol dehydrogenase (all-trans,NADPH)
is: SBO:0000176

metaR HPYRRy
name: Hydroxypyruvate reductase (NADPH)
kinetic law: MODEL1310110042#
modifier: MODEL1310110042#
reversible: false
type: Reaction
is: SBO:0000176
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (9380.1) SUBSYSTEM: Glyoxylate and dicarboxylate metabolism EC Number: 1.1.1.79 Confidence Level: 4 AUTHORS: PMID:2689175,PMID:9038835 NOTES:JLR
product: MODEL1310110042#
fast: false
reactant: MODEL1310110042#
is version of: http://identifiers.org/ec-code/1.1.1.79

http://identifiers.org/biomodels.db/MODEL1310110042#_e3daf4ff_a2d2_4178_b9cd_1eb1972988c7
initial amount: NaN
is encoded by: hsa:18
type: Species
constant: false
has only substance units: false
boundary condition: true
initial concentration: NaN
is: SBO:0000252
name: ABAT

http://identifiers.org/biomodels.db/MODEL1310110042#_fb9da649_7d15_44a8_bb34_23132b2d949c
is: SBO:0000252
name: SLC14A1
is encoded by: hsa:6563
type: Species
has only substance units: false
initial concentration: NaN
is: G0W2N5
initial amount: NaN
boundary condition: true
constant: false

metaM idour c
notes: FORMULA: C6H9O7 CHARGE: -1 INCHI: InChI=1S/C6H10O7/c7-1-2(8)3(9)4(10)5(11)6(12)13/h1-5,8-11H,(H,12,13)/p-1/t2-,3+,4-,5+/m0/s1
boundary condition: false
name: L-iduronate
is: SBO:0000247
has only substance units: false
is: CHEBI:21338
is: HMDB02704
constant: false
initial concentration: 1.0
type: Species
initial amount: NaN

metaR FACOAL191
product: MODEL1310110042#
reversible: false
reactant: MODEL1310110042#
modifier: MODEL1310110042#
is version of: http://identifiers.org/ec-code/6.2.1.3
type: Reaction
kinetic law: MODEL1310110042#
name: fatty-acid--CoA ligase
notes: GENE_ASSOCIATION: (11001.1) SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 4 AUTHORS: PMID:11591435 NOTES:current models suggest COAL activity occurs on outer peroxisomal membrane NJ
is: SBO:0000176
fast: false
is described by: ECO:0000269

metaR FRDPtcr
reactant: MODEL1310110042#
is described by: ECO:0000134
kinetic law: MODEL1310110042#
fast: false
product: MODEL1310110042#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: required for cholesterol synthesis in E.R. NOTES:required for cholesterol synthesis in E.R.
type: Reaction
name: transport of Farnesyl diphosphate into the endoplasmic reticulum
is: SBO:0000185
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110042#_8381c4d4_269d_40a6_9ceb_981e8b27b03e
name: _AU149534_1_e
type: Species
is: SBO:0000252
boundary condition: true
has only substance units: false
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:AU149534
constant: false

metaR r2380
fast: false
kinetic law: MODEL1310110042#
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
reactant: MODEL1310110042#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:16919238,PMID:17173541,PMID:18406340,PMID:8132483 NOTES:
is described by: ECO:0000000
reversible: true
is: SBO:0000185
type: Reaction
product: MODEL1310110042#

metaR FUCtly
type: Reaction
product: MODEL1310110042#
is: SBO:0000185
reversible: false
kinetic law: MODEL1310110042#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 2 AUTHORS: PMID:1751541,PMID:8993166 NOTES:
name: L-fucose efflux from lysosome
fast: false
is described by: ECO:0000000
reactant: MODEL1310110042#

metaM 3hmbcoa m
constant: false
boundary condition: false
name: (2S,3S)-3-hydroxy-2-methylbutanoyl-CoA(4-)
initial amount: NaN
is: CHEBI:57312
is: HMDB01356
initial concentration: 1.0
notes: FORMULA: C26H40N7O18P3S CHARGE: -4 INCHI: InChI=1S/C26H44N7O18P3S/c1-13(14(2)34)25(39)55-8-7-28-16(35)5-6-29-23(38)20(37)26(3,4)10-48-54(45,46)51-53(43,44)47-9-15-19(50-52(40,41)42)18(36)24(49-15)33-12-32-17-21(27)30-11-31-22(17)33/h11-15,18-20,24,34,36-37H,5-10H2,1-4H3,(H,28,35)(H,29,38)(H,43,44)(H,45,46)(H2,27,30,31)(H2,40,41,42)/p-4/t13-,14-,15+,18+,19+,20-,24+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01287 EHMN_ABBREVIATION: C04405
type: Species
has only substance units: false
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110042#_d52f7219_e3da_4727_be55_64af32bea2d2
is: SBO:0000252
initial amount: NaN
constant: false
initial concentration: NaN
is encoded by: hsa:3906
boundary condition: true
is: P00709
has only substance units: false
name: LALBA
type: Species

metaM ksi deg34 l
name: keratan sulfate I, degradation product 34
notes: FORMULA: C76H126N5O59S1 CHARGE: -1
initial amount: NaN
type: Species
is: CHEBI:16953
is: HMDB00812
boundary condition: false
initial concentration: 1.0
constant: false
has only substance units: false
is: SBO:0000247

metaM Sfglutth c
initial amount: NaN
initial concentration: 1.0
has only substance units: false
is: HMDB01550
name: S-formylglutathionate(1-)
notes: FORMULA: C11H16N3O7S CHARGE: -1 INCHI: InChI=1S/C11H17N3O7S/c12-6(11(20)21)1-2-8(16)14-7(4-22-5-15)10(19)13-3-9(17)18/h5-7H,1-4,12H2,(H,13,19)(H,14,16)(H,17,18)(H,20,21)/p-1/t6-,7-/m0/s1 EHMN_ABBREVIATION: C01031
boundary condition: false
constant: false
is: CHEBI:57688
is: SBO:0000247
type: Species

metaR 4HGLSDm
is version of: http://identifiers.org/ec-code/1.5.1.12
reversible: true
is described by: ECO:0000212
modifier: MODEL1310110042#
name: L-4-hydroxyglutamate semialdehyde dehydrogenase, mitochondrial
is: SBO:0000176
product: MODEL1310110042#
notes: GENE_ASSOCIATION: (8659.1) or (8659.2) SUBSYSTEM: Arginine and Proline Metabolism EC Number: 1.5.1.12 Confidence Level: 1 AUTHORS: PMID:15849464 NOTES:NCD
kinetic law: MODEL1310110042#
reactant: MODEL1310110042#
fast: false
type: Reaction

metaR ALAGLNNaEx
type: Reaction
product: MODEL1310110042#
name: L-alanine/L-glutamine Na-dependent exchange (Ala-L in)
reactant: MODEL1310110042#
is: SBO:0000185
reversible: false
notes: GENE_ASSOCIATION: (6510.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14530974 NOTES:SAB see Kanai and Hediger 2004 (2003), PMID 14530974
is described by: ECO:0000269
kinetic law: MODEL1310110042#
modifier: MODEL1310110042#
fast: false

http://identifiers.org/biomodels.db/MODEL1310110042#_d712b073_904c_4335_863b_7298e12d7e7f
is: Q9BRB3
is: SBO:0000252
initial concentration: NaN
name: PIGQ
boundary condition: true
has only substance units: false
type: Species
initial amount: NaN
constant: false
is encoded by: hsa:9091

metaR NAHCO3 HCLt
product: MODEL1310110042#
reactant: MODEL1310110042#
type: Reaction
is: SBO:0000185
name: bicarbonate transport (HCl/NaHCO3 exchange)
fast: false
modifier: MODEL1310110042#
kinetic law: MODEL1310110042#
notes: GENE_ASSOCIATION: (9498.1) or (57282.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14722772 NOTES:MM
reversible: true
is described by: ECO:0000269

http://identifiers.org/biomodels.db/MODEL1310110042#_482623e7_b7e8_4a0a_bc15_858bb6839345
has only substance units: false
initial amount: NaN
boundary condition: true
is: SBO:0000252
is encoded by: hsa:9154
type: Species
is: Q96PL7
initial concentration: NaN
constant: false
name: SLC28A1

http://identifiers.org/biomodels.db/MODEL1310110042#_0d307f95_47c7_4537_88f5_706af9021eca
initial amount: NaN
type: Species
has only substance units: false
boundary condition: true
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:10455
name: ECI2
constant: false
is: O75521

metaR RE1526M
type: Reaction
notes: GENE_ASSOCIATION: (3295.1) or (1962.1) or (3033.1) or (3028.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.1.1.35 Confidence Level: 0 AUTHORS: PMID:11451959 NOTES:
is version of: http://identifiers.org/ec-code/4.2.1.107
modifier: MODEL1310110042#
is version of: http://identifiers.org/ec-code/1.1.1.35
product: MODEL1310110042#
kinetic law: MODEL1310110042#
reversible: true
fast: false
is: SBO:0000176
is described by: ECO:0000000
reactant: MODEL1310110042#
name: RE1526

http://identifiers.org/biomodels.db/MODEL1310110042#_90a6dcb7_48b9_4980_ac75_ed5a749051a9
is: P09622
initial concentration: NaN
boundary condition: true
initial amount: NaN
has only substance units: false
constant: false
type: Species
is encoded by: hsa:1738
name: DLD
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110042#_25c995f5_0dbd_4bf1_a0d7_ae87574f92f7
name: CHST5
type: Species
initial concentration: NaN
is: SBO:0000252
is: Q9GZS9
constant: false
initial amount: NaN
is encoded by: hsa:23563
has only substance units: false
boundary condition: true

metaM glutcoa c
initial amount: NaN
type: Species
has only substance units: false
constant: false
initial concentration: 1.0
boundary condition: false
name: glutaryl-CoA(5-)
is: HMDB01339
is: SBO:0000247
notes: FORMULA: C26H37N7O19P3S CHARGE: -5 INCHI: InChI=1S/C26H42N7O19P3S/c1-26(2,21(39)24(40)29-7-6-15(34)28-8-9-56-17(37)5-3-4-16(35)36)11-49-55(46,47)52-54(44,45)48-10-14-20(51-53(41,42)43)19(38)25(50-14)33-13-32-18-22(27)30-12-31-23(18)33/h12-14,19-21,25,38-39H,3-11H2,1-2H3,(H,28,34)(H,29,40)(H,35,36)(H,44,45)(H,46,47)(H2,27,30,31)(H2,41,42,43)/p-5/t14-,19-,20-,21+,25-/m1/s1

metaR B3GALT5g
reversible: false
reactant: MODEL1310110042#
kinetic law: MODEL1310110042#
product: MODEL1310110042#
name: Beta-1,3-galactosyltransferase 5
is: SBO:0000176
type: Reaction
notes: GENE_ASSOCIATION: (10317.4) or (10317.1) or (10317.3) or (10317.2) or (10317.5) SUBSYSTEM: Sphingolipid metabolism EC Number: Confidence Level: 4 AUTHORS: NOTES:NJ
fast: false
is described by: ECO:0000269
modifier: MODEL1310110042#

metaR ALADGLYexR
modifier: MODEL1310110042#
kinetic law: MODEL1310110042#
is described by: ECO:0000304
is: SBO:0000185
notes: GENE_ASSOCIATION: (56301.1) and (6520.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10734121,PMID:10863037,PMID:14770310 NOTES:
reversible: true
name: D-alanine/glycine reversible exchange
fast: false
type: Reaction
product: MODEL1310110042#
reactant: MODEL1310110042#

metaR RE2988X
product: MODEL1310110042#
is version of: http://identifiers.org/ec-code/2.3.1.16
is: SBO:0000176
reactant: MODEL1310110042#
modifier: MODEL1310110042#
type: Reaction
name: RE2988
kinetic law: MODEL1310110042#
fast: false
notes: GENE_ASSOCIATION: (30.1) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.16 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:7775433 NOTES:
is described by: ECO:0000000
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110042#_40884ce6_1028_4517_875d_3ef5b244e1f5
name: _AI435857_1_x
has only substance units: false
constant: false
boundary condition: true
initial amount: NaN
type: Species
is: SBO:0000252
is encoded by: hsa:AI435857
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110042#_89aad42c_c40f_44dd_ac80_294b4e36957b
initial amount: NaN
is: SBO:0000252
name: DEGS1
is encoded by: hsa:8560
has only substance units: false
is: O15121
constant: false
boundary condition: true
initial concentration: NaN
type: Species

http://identifiers.org/biomodels.db/MODEL1310110042#_10095ca4_c470_4f89_882e_08b2830c4e12
boundary condition: true
is: Q59E93
is encoded by: hsa:290
initial concentration: NaN
type: Species
has only substance units: false
is: SBO:0000252
initial amount: NaN
constant: false
name: ANPEP

metaR GBA
reactant: MODEL1310110042#
name: Glucosylceramidase
kinetic law: MODEL1310110042#
modifier: MODEL1310110042#
type: Reaction
fast: false
is version of: http://identifiers.org/ec-code/3.2.1.45
is: SBO:0000176
product: MODEL1310110042#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (2629.2) or (2629.3) or (2629.4) or (2629.5) or (2629.1) SUBSYSTEM: Sphingolipid metabolism EC Number: 3.2.1.45 Confidence Level: 0 AUTHORS: PMID:15982918 NOTES:NJ
reversible: false

metaR EX c5dc
kinetic law: MODEL1310110042#
reactant: MODEL1310110042#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for glutaryl carnitine
type: Reaction

metaR P4502C8
type: Reaction
reactant: MODEL1310110042#
modifier: MODEL1310110042#
notes: GENE_ASSOCIATION: (1558.1) or (1558.2) SUBSYSTEM: Cytochrome metabolism EC Number: Confidence Level: 2 AUTHORS: PMID:15579107 NOTES:paclitaxol 6 alpha hydroxylation assumed to take place on outer membrane - xenobiotic metabolism NJ
is version of: http://identifiers.org/ec-code/1.14.14.1
is described by: ECO:0000304
product: MODEL1310110042#
fast: false
kinetic law: MODEL1310110042#
is: SBO:0000176
reversible: false
name: cytochrome P450 2C8

metaM icit m
is: CHEBI:16087
initial amount: NaN
initial concentration: 1.0
is: HMDB00193
has only substance units: false
type: Species
boundary condition: false
notes: FORMULA: C6H5O7 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00266 EHMN_ABBREVIATION: C00311
name: Isocitrate
constant: false
is: SBO:0000247
is: C00311

metaM idour e
initial concentration: 1.0
boundary condition: false
is: SBO:0000247
is: CHEBI:21338
is: HMDB02704
constant: false
has only substance units: false
name: L-iduronate
type: Species
initial amount: NaN
notes: FORMULA: C6H9O7 CHARGE: -1 INCHI: InChI=1S/C6H10O7/c7-1-2(8)3(9)4(10)5(11)6(12)13/h1-5,8-11H,(H,12,13)/p-1/t2-,3+,4-,5+/m0/s1

http://identifiers.org/biomodels.db/MODEL1310110042#_4cf3815d_2c58_4b30_9ba6_c92af30f5b37
is encoded by: hsa:293
constant: false
is: Q6I9V5
initial concentration: NaN
is: SBO:0000252
name: SLC25A6
type: Species
boundary condition: true
initial amount: NaN
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110042#_75fbc012_c3de_4ce2_b4c8_ee29d4d7e2dc
is: SBO:0000252
name: ATP10A
is encoded by: hsa:57194
initial amount: NaN
is: O60312
type: Species
constant: false
initial concentration: NaN
boundary condition: true
has only substance units: false

metaR CORE3GTg
name: Core 3 beta-GlcNAc-transferase, Golgi apparatus
reactant: MODEL1310110042#
type: Reaction
kinetic law: MODEL1310110042#
fast: false
notes: GENE_ASSOCIATION: (192134.1) SUBSYSTEM: O-glycan synthesis EC Number: 2.4.1.147 Confidence Level: 0 AUTHORS: PMID:11821425 NOTES:NCD
is described by: ECO:0000000
product: MODEL1310110042#
modifier: MODEL1310110042#
is version of: http://identifiers.org/ec-code/2.4.1.149
reversible: false
is: SBO:0000176

metaR TAGt
product: MODEL1310110042#
kinetic law: MODEL1310110042#
is described by: ECO:0000000
reversible: true
is: SBO:0000185
type: Reaction
reactant: MODEL1310110042#
name: triacylglycerol transport
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:
fast: false

metaR FAOXC16OHC16r
kinetic law: MODEL1310110042#
product: MODEL1310110042#
reactant: MODEL1310110042#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid omega oxidation(C16-->w-OHC16)er
type: Reaction

metaR EX tststerones LPAREN e RPAREN
kinetic law: MODEL1310110042#
reactant: MODEL1310110042#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: testosterone sulfate exchange
type: Reaction

metaR FAOXC141C121m
kinetic law: MODEL1310110042#
product: MODEL1310110042#
reactant: MODEL1310110042#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C14:1-->C12:1)m
type: Reaction

metaR r1922
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
product: MODEL1310110042#
is: SBO:0000185
name: Y+LAT2 Utilized transport
is described by: ECO:0000000
reactant: MODEL1310110042#
modifier: MODEL1310110042#
reversible: false
fast: false
kinetic law: MODEL1310110042#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110042#_f926aa7b_a35a_4140_8680_cb3b82ee7cfa
type: Species
boundary condition: true
is: SBO:0000252
constant: false
is: P47895
initial concentration: NaN
is encoded by: hsa:220
has only substance units: false
initial amount: NaN
name: ALDH1A3

metaM gacpail hs c
is: HMDB00128
is: CHEBI:16344
initial amount: NaN
initial concentration: 1.0
name: glucosaminyl-acylphosphatidylinositol
constant: false
type: Species
boundary condition: false
has only substance units: false
is: SBO:0000247
notes: FORMULA: C31H58NO14PFULLRCO2FULLR2CO2 CHARGE: 0

http://identifiers.org/biomodels.db/MODEL1310110042#_4ffb3275_e26e_43dd_bcc2_f90c982deb13
is: SBO:0000252
initial amount: NaN
constant: false
name: PPA1
type: Species
has only substance units: false
is encoded by: hsa:5464
is: Q15181
initial concentration: NaN
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110042#_b29d9636_cd31_4ced_8874_b2bd53855e66
boundary condition: true
is: SBO:0000252
is encoded by: hsa:51727
has only substance units: false
name: CMPK1
constant: false
type: Species
initial amount: NaN
initial concentration: NaN
is: B2R6S5

http://identifiers.org/biomodels.db/MODEL1310110042#_3aa9dc28_ccc6_4712_a1da_c49554628baa
initial amount: NaN
name: PNPLA3
type: Species
initial concentration: NaN
boundary condition: true
is: SBO:0000252
constant: false
has only substance units: false
is: Q9NST1
is encoded by: hsa:80339

metaR P4508B13r
is version of: http://identifiers.org/ec-code/1.14.13.95
is: SBO:0000176
reversible: false
product: MODEL1310110042#
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (1582.1) SUBSYSTEM: Bile acid synthesis EC Number: Confidence Level: 4 AUTHORS: NOTES:NJ - added, substrates by analogy to other xol hydroxylase reactions (NADH and NADPH can both be used)
type: Reaction
kinetic law: MODEL1310110042#
reactant: MODEL1310110042#
name: sterol 12-alpha-hydroxylase (nadh)
fast: false
modifier: MODEL1310110042#

metaM doco13ecoa c
initial concentration: 1.0
name: 13-docosenoylcoa
initial amount: NaN
is: SBO:0000247
constant: false
notes: FORMULA: C43H72N7O17P3S CHARGE: -4
type: Species
has only substance units: false
boundary condition: false
is: http://identifiers.org/pubchem.compound/24892791

metaR S2TASE2ly
reactant: MODEL1310110042#
is: SBO:0000176
reversible: false
notes: GENE_ASSOCIATION: (3423.1) or (3423.2) SUBSYSTEM: Heparan sulfate degradation EC Number: 3.1.6.13 Confidence Level: 4 AUTHORS: PMID:2122463,PMID:8244397,PMID:8530090,PMID:8993162 NOTES:NCD
name: iduronate-2-sulfatase, lysosomal
fast: false
modifier: MODEL1310110042#
kinetic law: MODEL1310110042#
is described by: ECO:0000000
product: MODEL1310110042#
is version of: http://identifiers.org/ec-code/3.1.6.13
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110042#_de78d0d2_f481_4e7b_8d86_838991a12ba5
type: Species
is: SBO:0000252
is: O15269
boundary condition: true
has only substance units: false
initial amount: NaN
is encoded by: hsa:10558
name: SPTLC1
initial concentration: NaN
constant: false

metaM n2m2nmasn e
notes: FORMULA: C58H96N5O40X CHARGE: 0
name: N-Acetyl-beta-D-glucosaminyl-1,2-alpha-D-mannosyl-1,3-(N-acetyl-beta-D-glucosaminyl-1,2-alpha-D-mannosyl-1,6)-(N-acetyl-beta-D-glucosaminyl-1,4)-beta-D-mannosyl-1,4-N-acetyl-beta-D-glucosaminyl-R
initial amount: NaN
constant: false
is: C04946
boundary condition: false
initial concentration: 1.0
has only substance units: false
type: Species
is: SBO:0000247

metaR P4502C9
is described by: ECO:0000269
type: Reaction
fast: false
is version of: http://identifiers.org/ec-code/1.14.13.48
product: MODEL1310110042#
name: cytochrome P450 2C9
notes: GENE_ASSOCIATION: (1559.1) SUBSYSTEM: Cytochrome metabolism EC Number: 1.14.14.1 Confidence Level: 4 AUTHORS: PMID:15579107,PMID:2827463,PMID:3032244 NOTES:tolbutamide 4 methyl hydroxylation assumed to take place on outer membrane - xenobiotic metabolism NJ
kinetic law: MODEL1310110042#
modifier: MODEL1310110042#
reactant: MODEL1310110042#
reversible: false
is: SBO:0000176

metaR DNDPt33m
type: Reaction
name: dGDP transport via dUDP antiport
modifier: MODEL1310110042#
reactant: MODEL1310110042#
notes: GENE_ASSOCIATION: (60386.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:11226231 NOTES:IT
kinetic law: MODEL1310110042#
is: SBO:0000185
reversible: false
product: MODEL1310110042#
is described by: ECO:0000269
fast: false

metaM man6p c
name: D-Mannose 6-phosphate
is: HMDB01078
notes: FORMULA: C6H11O9P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00246 EHMN_ABBREVIATION: C00275
is: CHEBI:17369
has only substance units: false
is: SBO:0000247
initial concentration: 1.0
constant: false
initial amount: NaN
type: Species
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110042#_604345d8_0b90_429d_b7a5_6b7459d944af
is: Q9BQG2
is encoded by: hsa:83594
is: SBO:0000252
name: NUDT12
constant: false
initial amount: NaN
initial concentration: NaN
has only substance units: false
type: Species
boundary condition: true

metaR RETFA
reactant: MODEL1310110042#
product: MODEL1310110042#
kinetic law: MODEL1310110042#
is: SBO:0000176
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Vitamin A metabolism EC Number: 2.3.1.76 Confidence Level: 2 AUTHORS: PMID:1503811 NOTES:IT
fast: false
name: retinol acyltransferase
reversible: false
type: Reaction

metaR r1921
type: Reaction
is: SBO:0000185
reactant: MODEL1310110042#
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reversible: false
fast: false
kinetic law: MODEL1310110042#
name: Y+LAT2 Utilized transport
is described by: ECO:0000000
modifier: MODEL1310110042#
product: MODEL1310110042#

metaM dump n
name: dUMP(2-)
initial concentration: 1.0
has only substance units: false
type: Species
constant: false
initial amount: NaN
is: SBO:0000247
notes: FORMULA: C9H11N2O8P CHARGE: -2 INCHI: InChI=1S/C9H13N2O8P/c12-5-3-8(11-2-1-7(13)10-9(11)14)19-6(5)4-18-20(15,16)17/h1-2,5-6,8,12H,3-4H2,(H,10,13,14)(H2,15,16,17)/p-2/t5-,6+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00309 EHMN_ABBREVIATION: C00365
boundary condition: false
is: HMDB01409
is: CHEBI:246422

http://identifiers.org/biomodels.db/MODEL1310110042#_2e64e14b_831c_4f20_84c9_690e36689588
is encoded by: hsa:51227
type: Species
initial concentration: NaN
constant: false
initial amount: NaN
has only substance units: false
name: PIGP
boundary condition: true
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110042#_33e7a1c1_04ed_4348_9a15_874c7307ed30
name: PLCG1
is: SBO:0000252
initial amount: NaN
initial concentration: NaN
constant: false
type: Species
has only substance units: false
boundary condition: true
is: P19174
is encoded by: hsa:5335

http://identifiers.org/biomodels.db/MODEL1310110042#_8e3e94eb_4c42_43cb_a544_ea1522ebcb33
boundary condition: true
initial concentration: NaN
type: Species
has only substance units: false
is encoded by: hsa:10026
constant: false
initial amount: NaN
is: Q92643
is: SBO:0000252
name: PIGK

metaR PPA
notes: GENE_ASSOCIATION: (5464.1) SUBSYSTEM: Oxidative phosphorylation EC Number: 3.6.1.1 Confidence Level: 4 AUTHORS: PMID:10542310,PMID:15533045 NOTES:
is version of: http://identifiers.org/ec-code/3.6.1.1
type: Reaction
is: SBO:0000176
fast: false
reactant: MODEL1310110042#
kinetic law: MODEL1310110042#
product: MODEL1310110042#
is described by: ECO:0000269
name: inorganic diphosphatase
reversible: false
modifier: MODEL1310110042#

metaR G14T10g
reversible: false
reactant: MODEL1310110042#
is version of: http://identifiers.org/ec-code/2.4.1.38
product: MODEL1310110042#
notes: GENE_ASSOCIATION: (9334.1) or (2683.1) or (8703.1) or (8704.2) or (8704.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.38 Confidence Level: 4 AUTHORS: PMID:12512857,PMID:1903938,PMID:3094506,PMID:3144273,PMID:9405390,PMID:9435216 NOTES:Keratan sulfate I biosynthesis NCD
is version of: http://identifiers.org/ec-code/2.4.1.90
type: Reaction
is version of: http://identifiers.org/ec-code/2.4.1.22
name: beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase, Golgi
is: SBO:0000176
kinetic law: MODEL1310110042#
fast: false
is described by: ECO:0000000
modifier: MODEL1310110042#

http://identifiers.org/biomodels.db/MODEL1310110042#_76c4bf67_4da9_4c79_abfb_7b011ea42d54
has only substance units: false
is: SBO:0000252
is: Q5DSZ6
initial amount: NaN
boundary condition: true
constant: false
initial concentration: NaN
name: UGT1A8
type: Species
is encoded by: hsa:54576

metaM 2dr1p c
is: CHEBI:58576
constant: false
type: Species
is: SBO:0000247
boundary condition: false
is: C00672
has only substance units: false
initial concentration: 1.0
name: 2-Deoxy-D-ribose 1-phosphate
notes: FORMULA: C5H9O7P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00489 EHMN_ABBREVIATION: C00672
initial amount: NaN
is: HMDB01351

metaR FAOXC101x
kinetic law: MODEL1310110042#
product: MODEL1310110042#
reactant: MODEL1310110042#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: isomerization(C10:1)x
type: Reaction

metaR TAUBETAtc
kinetic law: MODEL1310110042#
product: MODEL1310110042#
reactant: MODEL1310110042#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of taurine into the intestinal cells by beta transport system
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110042#_81111d6a_deb1_49e5_91ba_59ba6a57eeca
initial amount: NaN
type: Species
has only substance units: false
constant: false
is encoded by: hsa:2629
initial concentration: NaN
is: B7Z6S9
is: SBO:0000252
name: GBA
boundary condition: true

metaR APOC LYS BTNP
fast: false
reversible: false
reactant: MODEL1310110042#
is: SBO:0000176
is described by: ECO:0000000
name: proteolysis of apoC-Lys-btn
product: MODEL1310110042#
kinetic law: MODEL1310110042#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Biotin metabolism EC Number: Confidence Level: 2 AUTHORS: NOTES:

http://identifiers.org/biomodels.db/MODEL1310110042#_2e85b834_1493_44ed_acbd_97a28f1f5426
is: SBO:0000252
has only substance units: false
is: Q99798
initial amount: NaN
constant: false
initial concentration: NaN
boundary condition: true
type: Species
name: ACO2
is encoded by: hsa:50

metaR r1920
product: MODEL1310110042#
name: Y+LAT2 Utilized transport
modifier: MODEL1310110042#
reversible: false
is: SBO:0000185
is described by: ECO:0000000
kinetic law: MODEL1310110042#
reactant: MODEL1310110042#
fast: false
type: Reaction
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:

metaM hs deg5 l
type: Species
name: heparan sulfate, degradation product 5
notes: FORMULA: C67H97N4O86S10 CHARGE: -11
constant: false
is: HMDB00158
is: CHEBI:17895
initial concentration: 1.0
initial amount: NaN
has only substance units: false
boundary condition: false
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110042#_ca74be77_3c28_40bc_95b5_e15e99063a37
is: O95528
is encoded by: hsa:81031
name: SLC2A10
boundary condition: true
initial concentration: NaN
constant: false
type: Species
has only substance units: false
is: SBO:0000252
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110042#_42e67d7c_7972_4ab5_8bcb_d96436cc6081
is: SBO:0000252
name: _H17063_1_c
initial amount: NaN
initial concentration: NaN
type: Species
has only substance units: false
boundary condition: true
is encoded by: hsa:H17063
constant: false

metaR S6T14g
reactant: MODEL1310110042#
modifier: MODEL1310110042#
name: galactose/N-acetylglucosamine 6-O-sulfotransferase, Golgi apparatus
is: SBO:0000176
product: MODEL1310110042#
kinetic law: MODEL1310110042#
notes: GENE_ASSOCIATION: (23563.2) or (9435.1) or (23563.1) or (10164.1) or (4166.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: Confidence Level: 4 AUTHORS: PMID:10330415,PMID:10491328,PMID:10913333,PMID:11278593,PMID:12403612,PMID:12855678,PMID:9722682 NOTES:NCD
fast: false
type: Reaction
is described by: ECO:0000000
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110042#_8778f6f0_b495_47fb_8fdc_a488fe05869e
type: Species
boundary condition: true
initial amount: NaN
constant: false
name: CCBL1
initial concentration: NaN
is: Q16773
has only substance units: false
is encoded by: hsa:883
is: SBO:0000252

metaR OCTAt
kinetic law: MODEL1310110042#
is: SBO:0000185
reactant: MODEL1310110042#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:JLR
type: Reaction
product: MODEL1310110042#
is described by: ECO:0000000
reversible: true
fast: false
name: Octanoate transport via diffusion

http://identifiers.org/biomodels.db/MODEL1310110042#_c68a6d1c_7c6b_407d_a21d_d20539e73fd8
has only substance units: false
name: SLC16A10
is encoded by: hsa:117247
initial amount: NaN
is: SBO:0000252
is: Q8TF71
initial concentration: NaN
constant: false
type: Species
boundary condition: true

metaR RE2626C
is: SBO:0000176
fast: false
is described by: ECO:0000000
type: Reaction
kinetic law: MODEL1310110042#
notes: GENE_ASSOCIATION: SUBSYSTEM: Bile acid synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:9210654,PMID:9660774 NOTES:
reversible: true
name: RE2626
reactant: MODEL1310110042#
product: MODEL1310110042#

metaR C6DCCACT
kinetic law: MODEL1310110042#
product: MODEL1310110042#
reactant: MODEL1310110042#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: transport of adipoyl carnitine into cytosol
type: Reaction

metaM CE0233 c
is: CHEBI:17899
type: Species
name: 5beta-cholestane-3alpha,7alpha,27-triol
boundary condition: false
initial concentration: 1.0
constant: false
notes: FORMULA: C27H48O3 CHARGE: 0 INCHI: InChI=1/C27H48O3/c1-17(7-6-12-25(2,3)30)20-8-9-21-24-22(11-14-27(20,21)5)26(4)13-10-19(28)15-18(26)16-23(24)29/h17-24,28-30H,6-16H2,1-5H3/t17-,18-,19+,20-,21-,22-,23+,24-,26?,27-/m1/s1 EHMN_ABBREVIATION: CE0233
has only substance units: false
initial amount: NaN
is: HMDB01993
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110042#_06b1cec1_2009_41ce_9c0e_48a2ad9a5c01
is: SBO:0000252
is: O94788
has only substance units: false
is encoded by: hsa:8854
initial amount: NaN
name: ALDH1A2
constant: false
boundary condition: true
initial concentration: NaN
type: Species

metaR FAOXC14C14OHm
kinetic law: MODEL1310110042#
product: MODEL1310110042#
reactant: MODEL1310110042#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C14-->C14OH)m
type: Reaction

metaR r0552
reversible: true
name: p-cumic alcohol:NAD+ oxidoreductase Glycine, serine and threonine metabolism EC:1.2.1.8
notes: GENE_ASSOCIATION: (AF080579.1) or (AI348006.1) or (6389.1) or (6390.1) or (6391.1) or (6392.1) or (642502.1) SUBSYSTEM: Glycine, serine, alanine and threonine metabolism EC Number: 1.2.1.8 Confidence Level: 0 AUTHORS: PMID:10505788,PMID:7646513 NOTES:
type: Reaction
is described by: ECO:0000000
modifier: MODEL1310110042#
is: SBO:0000176
reactant: MODEL1310110042#
fast: false
is version of: http://identifiers.org/ec-code/1.3.5.1
kinetic law: MODEL1310110042#
product: MODEL1310110042#

metaM so4 c
constant: false
type: Species
has only substance units: false
is: HMDB01448
initial amount: NaN
name: sulfate
notes: FORMULA: O4S CHARGE: -2 INCHI: InChI=1S/H2O4S/c1-5(2,3)4/h(H2,1,2,3,4)/p-2 HEPATONET_1.0_ABBREVIATION: HC00062 EHMN_ABBREVIATION: C00059
initial concentration: 1.0
boundary condition: false
is: SBO:0000247
is: CHEBI:16189

http://identifiers.org/biomodels.db/MODEL1310110042#_d64ff3f9_bd77_4b93_b33f_8c0845f13252
is: Q96CD2
constant: false
is encoded by: hsa:60490
has only substance units: false
initial concentration: NaN
initial amount: NaN
type: Species
boundary condition: true
name: PPCDC
is: SBO:0000252

metaM fru c
is: CHEBI:15824
is: SBO:0000247
type: Species
initial concentration: 1.0
boundary condition: false
is: C00095
notes: FORMULA: C6H12O6 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00097 EHMN_ABBREVIATION: C00095
has only substance units: false
is: HMDB00660
constant: false
initial amount: NaN
name: D-Fructose

metaM 3ddcrn c
initial concentration: 1.0
is: SBO:0000247
has only substance units: false
is: HMDB00623
type: Species
notes: FORMULA: C19H37NO5 CHARGE: 0
initial amount: NaN
name: 3-hydroxydodecanoylcarnitine
boundary condition: false
constant: false

metaR EX tymsf LPAREN e RPAREN
kinetic law: MODEL1310110042#
reactant: MODEL1310110042#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Tyramine O-sulfate exchange
type: Reaction

metaM glc D e
type: Species
boundary condition: false
has only substance units: false
initial amount: NaN
is: CHEBI:4167
is: SBO:0000247
initial concentration: 1.0
name: D-glucose
is: HMDB00122
notes: FORMULA: C6H12O6 CHARGE: 0 INCHI: InChI=1S/C6H12O6/c7-1-2-3(8)4(9)5(10)6(11)12-2/h2-11H,1H2/t2-,3-,4+,5-,6?/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00040
constant: false

metaM ksi deg18 l
is: SBO:0000247
name: keratan sulfate I, degradation product 18
is: HMDB00143
notes: FORMULA: C146H235N10O127S7 CHARGE: -7
constant: false
initial concentration: 1.0
initial amount: NaN
is: CHEBI:12936
boundary condition: false
has only substance units: false
type: Species

metaR RE1898C
is described by: ECO:0000000
product: MODEL1310110042#
fast: false
reactant: MODEL1310110042#
reversible: true
type: Reaction
name: RE1898
notes: GENE_ASSOCIATION: SUBSYSTEM: Urea cycle EC Number: 2.5.1.46 Confidence Level: 0 AUTHORS: PMID:9188485 NOTES:
is: SBO:0000176
kinetic law: MODEL1310110042#

metaR r0651
name: Chenodeoxycholate:CoA ligase (AMP-forming) Bile acid biosynthesis EC:6.2.1.7
reactant: MODEL1310110042#
is described by: ECO:0000000
reversible: true
is version of: http://identifiers.org/ec-code/1.5.1.2
kinetic law: MODEL1310110042#
type: Reaction
is: SBO:0000176
modifier: MODEL1310110042#
product: MODEL1310110042#
fast: false
notes: GENE_ASSOCIATION: (10637.1) or (5831.1) or (29920.1) or (65263.1) SUBSYSTEM: Bile acid synthesis EC Number: 6.2.1.7 Confidence Level: 0 AUTHORS: PMID:10749848,PMID:10884298,PMID:15026425,PMID:438652,PMID:6173037 NOTES:

metaM HC01406 m
notes: FORMULA: C29H44N7O18P3S CHARGE: -4 INCHI: InChI=1S/C29H48N7O18P3S/c1-4-5-6-7-17(37)12-20(39)58-11-10-31-19(38)8-9-32-27(42)24(41)29(2,3)14-51-57(48,49)54-56(46,47)50-13-18-23(53-55(43,44)45)22(40)28(52-18)36-16-35-21-25(30)33-15-34-26(21)36/h15-16,18,22-24,28,40-41H,4-14H2,1-3H3,(H,31,38)(H,32,42)(H,46,47)(H,48,49)(H2,30,33,34)(H2,43,44,45)/t18-,22-,23-,24+,28-/m1/s1 EHMN_ABBREVIATION: C05267
is: CHEBI:28264
is: SBO:0000247
has only substance units: false
initial concentration: 1.0
name: 3-Oxooctanoyl-CoA
type: Species
constant: false
boundary condition: false
initial amount: NaN

metaR r2387
notes: GENE_ASSOCIATION: (215.1) or (U52111.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172 NOTES:
reversible: false
reactant: MODEL1310110042#
is described by: ECO:0000000
product: MODEL1310110042#
kinetic law: MODEL1310110042#
type: Reaction
modifier: MODEL1310110042#
fast: false
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110042#_53c60a2b_2def_4610_bffd_f1a76be10a61
has only substance units: false
constant: false
is: SBO:0000252
boundary condition: true
initial concentration: NaN
initial amount: NaN
name: SLC35B2
type: Species
is encoded by: hsa:347734
is: Q8TB61

metaR BILIRUBt2
notes: GENE_ASSOCIATION: (10599.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10358072,PMID:12507753,PMID:9334206 NOTES:NJ
is: SBO:0000185
name: bilirubin transport via bicarbonate countertransport
fast: false
kinetic law: MODEL1310110042#
reversible: true
is described by: ECO:0000269
type: Reaction
modifier: MODEL1310110042#
reactant: MODEL1310110042#
product: MODEL1310110042#

http://identifiers.org/biomodels.db/MODEL1310110042#_8e973e71_5cfb_4266_808a_84bcc5191193
name: HLCS
initial concentration: NaN
initial amount: NaN
boundary condition: true
type: Species
constant: false
is encoded by: hsa:3141
is: SBO:0000252
has only substance units: false
is: P50747

http://identifiers.org/biomodels.db/MODEL1310110042#_da788652_2d60_48f1_940d_8b6d91e7d3a3
is: SBO:0000252
has only substance units: false
is encoded by: hsa:53354
initial amount: NaN
type: Species
is: Q8TE04
boundary condition: true
name: PANK1
constant: false
initial concentration: NaN

metaR ACOAD1fm
is described by: ECO:0000269
name: acyl-CoA dehydrogenase (butanoyl-CoA), mitochondrial
notes: GENE_ASSOCIATION: (80724.1) or (36.1) or (35.1) or (34.1) or (84129.1) or (27034.1) or (28976.1) SUBSYSTEM: Butanoate metabolism EC Number: 1.3.99.2 Confidence Level: 4 AUTHORS: PMID:2565344 NOTES:Assume NAD/NADH as acceptors Lumped long-chain acyl-CoA dehydrogenase (EC 1.3.99.13) This reaction is therefore equilivalent to trans-2-enoyl-CoA reductase (NAD) (EC 1.3.1.44)
reactant: MODEL1310110042#
is: SBO:0000176
reversible: false
product: MODEL1310110042#
kinetic law: MODEL1310110042#
fast: false
modifier: MODEL1310110042#
is version of: http://identifiers.org/ec-code/1.3.8.1
is version of: http://identifiers.org/ec-code/1.3.99.3
type: Reaction

metaR r0553
name: p-Cumic alcohol:NADP+ oxidoreductase Glycine, serine and threonine metabolism EC:1.2.1.8
notes: GENE_ASSOCIATION: SUBSYSTEM: Glycine, serine, alanine and threonine metabolism EC Number: 1.2.1.8 Confidence Level: 0 AUTHORS: PMID:10505788,PMID:7646513 NOTES:
reactant: MODEL1310110042#
fast: false
reversible: true
type: Reaction
is described by: ECO:0000000
kinetic law: MODEL1310110042#
is: SBO:0000176
product: MODEL1310110042#

metaM dcyt c
name: Deoxycytidine
initial amount: NaN
initial concentration: 1.0
notes: FORMULA: C9H13N3O4 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00574 EHMN_ABBREVIATION: C00881
is: C00881
is: SBO:0000247
boundary condition: false
has only substance units: false
type: Species
is: HMDB00014
constant: false
is: CHEBI:15698

metaM n2m2nmasn l
notes: FORMULA: C58H96N5O40X CHARGE: 0
is: C04946
type: Species
name: N-Acetyl-beta-D-glucosaminyl-1,2-alpha-D-mannosyl-1,3-(N-acetyl-beta-D-glucosaminyl-1,2-alpha-D-mannosyl-1,6)-(N-acetyl-beta-D-glucosaminyl-1,4)-beta-D-mannosyl-1,4-N-acetyl-beta-D-glucosaminyl-R
initial amount: NaN
boundary condition: false
has only substance units: false
is: SBO:0000247
constant: false
initial concentration: 1.0

metaR SLDx
reversible: true
modifier: MODEL1310110042#
product: MODEL1310110042#
reactant: MODEL1310110042#
is version of: http://identifiers.org/ec-code/1.1.1.37
name: L-sulfolactate dehydrogenase (NAD+)
is described by: ECO:0000304
type: Reaction
notes: GENE_ASSOCIATION: (4190.1) or (130752.1) SUBSYSTEM: Methionine and cysteine metabolism EC Number: 1.1.1.272 Confidence Level: 2 AUTHORS: PMID:15758220,PMID:3346220 NOTES:AMF EC: 1.1.1.272
kinetic law: MODEL1310110042#
fast: false
is: SBO:0000176

metaR r0652
kinetic law: MODEL1310110042#
is described by: ECO:0000000
fast: false
is version of: http://identifiers.org/ec-code/1.5.1.2
reversible: true
product: MODEL1310110042#
name: trans-Tetradec-2-enoyl-CoA reductase Fatty acid elongation in mitochondria EC:1.3.1.38
notes: GENE_ASSOCIATION: (10637.1) or (5831.1) or (29920.1) or (65263.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.1.38 Confidence Level: 0 AUTHORS: PMID:12654921 NOTES:
type: Reaction
is: SBO:0000176
reactant: MODEL1310110042#
modifier: MODEL1310110042#

metaR r2386
product: MODEL1310110042#
kinetic law: MODEL1310110042#
fast: false
is described by: ECO:0000000
is: SBO:0000185
notes: GENE_ASSOCIATION: (215.1) or (U52111.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172 NOTES:
reversible: false
reactant: MODEL1310110042#
type: Reaction
modifier: MODEL1310110042#
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2

metaR PPM
is version of: http://identifiers.org/ec-code/5.4.2.2
name: phosphopentomutase
modifier: MODEL1310110042#
reversible: true
type: Reaction
kinetic law: MODEL1310110042#
is described by: ECO:0000000
reactant: MODEL1310110042#
notes: GENE_ASSOCIATION: (5236.1) SUBSYSTEM: Pentose phosphate pathway EC Number: 5.4.2.7 Confidence Level: 0 AUTHORS: NOTES:
is: SBO:0000176
product: MODEL1310110042#
fast: false

metaR C6CRNe
kinetic law: MODEL1310110042#
product: MODEL1310110042#
reactant: MODEL1310110042#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of hexanoyl carnitine into the extra cellular fluid
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110042#_68f2f6b5_2a18_4414_89a1_9404500144d2
boundary condition: true
is: P27707
is encoded by: hsa:1633
is: SBO:0000252
name: DCK
initial concentration: NaN
constant: false
type: Species
initial amount: NaN
has only substance units: false

metaR PTDCACRNt
product: MODEL1310110042#
notes: GENE_ASSOCIATION: (788.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: PMID:14598172 NOTES:NJ
modifier: MODEL1310110042#
is: SBO:0000185
kinetic law: MODEL1310110042#
type: Reaction
reactant: MODEL1310110042#
is described by: ECO:0000000
fast: false
reversible: false
name: pentadecanoate transport into the mitochondria

metaR r2389
type: Reaction
fast: false
reactant: MODEL1310110042#
kinetic law: MODEL1310110042#
product: MODEL1310110042#
is: SBO:0000185
reversible: false
modifier: MODEL1310110042#
notes: GENE_ASSOCIATION: (215.1) or (U52111.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172 NOTES:
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
is described by: ECO:0000000

metaR EX CE1926 LPAREN e RPAREN
kinetic law: MODEL1310110042#
reactant: MODEL1310110042#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: gama-carboxyethyl-hydroxychroman exchange
type: Reaction

metaM glutcoa m
has only substance units: false
is: HMDB01339
is: SBO:0000247
is: CHEBI:57378
notes: FORMULA: C26H37N7O19P3S CHARGE: -5 INCHI: InChI=1S/C26H42N7O19P3S/c1-26(2,21(39)24(40)29-7-6-15(34)28-8-9-56-17(37)5-3-4-16(35)36)11-49-55(46,47)52-54(44,45)48-10-14-20(51-53(41,42)43)19(38)25(50-14)33-13-32-18-22(27)30-12-31-23(18)33/h12-14,19-21,25,38-39H,3-11H2,1-2H3,(H,28,34)(H,29,40)(H,35,36)(H,44,45)(H,46,47)(H2,27,30,31)(H2,41,42,43)/p-5/t14-,19-,20-,21+,25-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00411 EHMN_ABBREVIATION: C00527
type: Species
constant: false
initial concentration: 1.0
boundary condition: false
name: glutaryl-CoA(5-)
initial amount: NaN

metaR ACOAD10m
product: MODEL1310110042#
reversible: false
notes: GENE_ASSOCIATION: (36.1) or (34.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 1.3.99.12 Confidence Level: 4 AUTHORS: PMID:11013134 NOTES:MM
is: SBO:0000176
name: acyl-CoA dehydrogenase (2-methylbutanoyl-CoA), mitochondrial
type: Reaction
modifier: MODEL1310110042#
reactant: MODEL1310110042#
is described by: ECO:0000269
fast: false
is version of: http://identifiers.org/ec-code/1.3.99.3
kinetic law: MODEL1310110042#

http://identifiers.org/biomodels.db/MODEL1310110042#_c71cd198_1229_4ee6_9820_f19929c6290c
constant: false
has part: P22392
boundary condition: true
has only substance units: false
is encoded by: hsa:4830
type: Species
initial amount: NaN
is: SBO:0000297
initial concentration: NaN
is encoded by: hsa:4831
has part: P15531
name: NME1:NME2

metaR ALASm
reactant: MODEL1310110042#
is described by: ECO:0000254
notes: GENE_ASSOCIATION: (212.1) or (23464.1) or (211.2) or (211.1) SUBSYSTEM: Glycine, serine, alanine and threonine metabolism EC Number: 2.3.1.37 Confidence Level: 2 AUTHORS: PMID:2263504 NOTES:NCD
fast: false
modifier: MODEL1310110042#
is version of: http://identifiers.org/ec-code/2.3.1.37
type: Reaction
is version of: http://identifiers.org/ec-code/2.3.1.29
name: 5-aminolevulinate synthase
is: SBO:0000176
kinetic law: MODEL1310110042#
reversible: false
product: MODEL1310110042#

metaR NODe
fast: false
name: NODe
is: SBO:0000185
product: MODEL1310110042#
reactant: MODEL1310110042#
type: Reaction
kinetic law: MODEL1310110042#
is described by: ECO:0000134
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
reversible: true

metaM 3ddcrn e
initial concentration: 1.0
constant: false
initial amount: NaN
name: 3-hydroxydodecanoylcarnitine
boundary condition: false
is: SBO:0000247
is: HMDB00791
is: C02838
type: Species
has only substance units: false
notes: FORMULA: C19H37NO5 CHARGE: 0

http://identifiers.org/biomodels.db/MODEL1310110042#_7d442bff_e526_473c_9bcc_d76ea3893892
constant: false
type: Species
has only substance units: false
initial concentration: NaN
initial amount: NaN
is: SBO:0000252
boundary condition: true
name: PIP4K2A
is encoded by: hsa:5305
is: P48426

metaR GAMt1r
is described by: ECO:0000269
kinetic law: MODEL1310110042#
name: glucosamine transport (uniport)
reactant: MODEL1310110042#
notes: GENE_ASSOCIATION: (6513.1) or (6517.1) or (6514.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:11882499,PMID:12135767,PMID:12750891,PMID:1701966,PMID:2182619,PMID:2656669,PMID:3103217,PMID:3399500,PMID:3839598,PMID:7926364,PMID:9770484 NOTES:
reversible: true
fast: false
type: Reaction
is: SBO:0000185
modifier: MODEL1310110042#
product: MODEL1310110042#

http://identifiers.org/biomodels.db/MODEL1310110042#_95f23fb2_998c_4b7c_be97_531076b3b281
initial concentration: NaN
name: ATP5A1
is: P25705
boundary condition: true
is: SBO:0000252
initial amount: NaN
constant: false
type: Species
has only substance units: false
is encoded by: hsa:498

http://identifiers.org/biomodels.db/MODEL1310110042#_f56ed44b_54ed_4d96_8003_c479683cb29d
is: SBO:0000252
is: Q8IXK2
boundary condition: true
initial concentration: NaN
name: GALNT12
constant: false
initial amount: NaN
type: Species
is encoded by: hsa:79695
has only substance units: false

metaR r2388
kinetic law: MODEL1310110042#
product: MODEL1310110042#
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
is described by: ECO:0000000
is: SBO:0000185
reversible: false
type: Reaction
notes: GENE_ASSOCIATION: (215.1) or (U52111.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172 NOTES:
fast: false
reactant: MODEL1310110042#
modifier: MODEL1310110042#

metaM dolglcp L c
boundary condition: false
notes: FORMULA: C1140H1868O90P10 CHARGE: -10 INCHI: InChI=1S/C31H55O9P/c1-22(2)11-7-12-23(3)13-8-14-24(4)15-9-16-25(5)17-10-18-26(6)19-20-38-41(36,37)40-31-30(35)29(34)28(33)27(21-32)39-31/h11,13,15,17,26-35H,7-10,12,14,16,18-21H2,1-6H3,(H,36,37)/b23-13+,24-15+,25-17-/t26?,27-,28-,29+,30-,31+/m1/s1
constant: false
type: Species
initial concentration: 1.0
initial amount: NaN
has only substance units: false
is: SBO:0000247
name: Dolichyl beta-D-glucosyl phosphate, human liver homolog
is: CHEBI:15812

metaM glc D c
boundary condition: false
constant: false
type: Species
has only substance units: false
notes: FORMULA: C6H12O6 CHARGE: 0 INCHI: InChI=1S/C6H12O6/c7-1-2-3(8)4(9)5(10)6(11)12-2/h2-11H,1H2/t2-,3-,4+,5-,6?/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00040
name: D-glucose
initial amount: NaN
is: CHEBI:4167
is: SBO:0000247
initial concentration: 1.0
is: HMDB00122

metaM 3hexdcoa m
initial concentration: 1.0
has only substance units: false
is: HMDB03932
boundary condition: false
constant: false
notes: FORMULA: C37H62N7O18P3S CHARGE: -4
is: SBO:0000247
type: Species
is: C05258
initial amount: NaN
name: 3-hydroxyhexadecanoylcoa

metaM ksi deg1 l
name: keratan sulfate I, degradation product 1
is: HMDB00174
has only substance units: false
initial amount: NaN
is: SBO:0000247
initial concentration: 1.0
notes: FORMULA: C241H383N17O209S12X CHARGE: -13
is: CHEBI:18287
constant: false
type: Species
boundary condition: false

metaM f1a l
initial amount: NaN
notes: FORMULA: C22H37N2O15X CHARGE: 0
type: Species
name: F1alpha
initial concentration: 1.0
constant: false
boundary condition: false
is: SBO:0000247
is: CHEBI:15936
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110042#_cfb147c7_50c6_46c0_9632_df68ab27f7bc
is: Q13956
type: Species
is encoded by: hsa:5149
constant: false
initial concentration: NaN
has only substance units: false
boundary condition: true
initial amount: NaN
name: PDE6H
is: SBO:0000252

metaR r0650
name: Chenodeoxycholate:CoA ligase (AMP-forming) Bile acid biosynthesis EC:6.2.1.7
is described by: ECO:0000000
fast: false
is version of: http://identifiers.org/ec-code/4.1.1.36
reversible: true
product: MODEL1310110042#
modifier: MODEL1310110042#
type: Reaction
is: SBO:0000176
reactant: MODEL1310110042#
kinetic law: MODEL1310110042#
notes: GENE_ASSOCIATION: (60490.1) SUBSYSTEM: Bile acid synthesis EC Number: 6.2.1.7 Confidence Level: 0 AUTHORS: PMID:10749848,PMID:10884298,PMID:15026425,PMID:438652,PMID:6173037 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110042#_08711b5c_2693_455b_be01_2cb5db0c1b1e
initial concentration: NaN
boundary condition: true
initial amount: NaN
has only substance units: false
has part: A3KLL5
constant: false
has part: B7Z2T0
type: Species
is: SBO:0000297
is encoded by: hsa:481
name: ATP1A3:ATP1B1
is encoded by: hsa:478

http://identifiers.org/biomodels.db/MODEL1310110042#_c1729b68_02e4_4183_9962_79b57f1e77eb
has only substance units: false
boundary condition: true
name: ACAT1
is: P24752
is: SBO:0000252
constant: false
is encoded by: hsa:38
type: Species
initial amount: NaN
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110042#_c7ab1af6_9f4e_405d_bf69_83d3f6b9e285
initial amount: NaN
name: ACOT2
boundary condition: true
constant: false
is encoded by: hsa:10965
initial concentration: NaN
is: P49753
has only substance units: false
type: Species
is: SBO:0000252

metaM hxcoa x
name: Hexanoyl-CoA (n-C6:0CoA)
is: HMDB00705
initial amount: NaN
constant: false
initial concentration: 1.0
type: Species
notes: FORMULA: C27H42N7O17P3S CHARGE: -4
has only substance units: false
is: SBO:0000247
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110042#_5df48e00_518d_46af_913f_c97252fb5aa5
is: Q9UNK4
initial concentration: NaN
is encoded by: hsa:26279
initial amount: NaN
name: PLA2G2D
constant: false
boundary condition: true
type: Species
has only substance units: false
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110042#_5ad36946_6815_4691_a6ec_fe696c6033bc
is: O75746
initial concentration: NaN
constant: false
is encoded by: hsa:8604
initial amount: NaN
type: Species
boundary condition: true
has only substance units: false
name: SLC25A12
is: SBO:0000252

metaM 7dhchsterol c
boundary condition: false
initial amount: NaN
is: CHEBI:17759
is: HMDB00032
has only substance units: false
name: cholesta-5,7-dien-3beta-ol
initial concentration: 1.0
type: Species
notes: FORMULA: C27H44O CHARGE: 0 INCHI: InChI=1S/C27H44O/c1-18(2)7-6-8-19(3)23-11-12-24-22-10-9-20-17-21(28)13-15-26(20,4)25(22)14-16-27(23,24)5/h9-10,18-19,21,23-25,28H,6-8,11-17H2,1-5H3/t19-,21+,23-,24+,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00693 EHMN_ABBREVIATION: C01164
constant: false
is: SBO:0000247

metaM idour l
boundary condition: false
is: CHEBI:21338
is: HMDB02704
constant: false
name: L-iduronate
has only substance units: false
type: Species
notes: FORMULA: C6H9O7 CHARGE: -1 INCHI: InChI=1S/C6H10O7/c7-1-2(8)3(9)4(10)5(11)6(12)13/h1-5,8-11H,(H,12,13)/p-1/t2-,3+,4-,5+/m0/s1
initial concentration: 1.0
is: SBO:0000247
initial amount: NaN

metaR ARACHCRNt
name: transport into the mitochondria (carnitine)
type: Reaction
notes: GENE_ASSOCIATION: (788.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: NOTES:NJ
reactant: MODEL1310110042#
reversible: false
modifier: MODEL1310110042#
is: SBO:0000185
fast: false
product: MODEL1310110042#
kinetic law: MODEL1310110042#
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110042#_0747f19e_0ae3_47a8_b627_72df383f50e0
is encoded by: hsa:AV717590
has only substance units: false
constant: false
name: _AV717590_1_c
initial concentration: NaN
is: SBO:0000252
boundary condition: true
type: Species
initial amount: NaN

metaM 3mob c
initial concentration: 1.0
is: HMDB00019
is: CHEBI:11851
type: Species
boundary condition: false
initial amount: NaN
constant: false
has only substance units: false
is: SBO:0000247
notes: FORMULA: C5H7O3 CHARGE: -1 INCHI: InChI=1S/C5H8O3/c1-3(2)4(6)5(7)8/h3H,1-2H3,(H,7,8)/p-1 HEPATONET_1.0_ABBREVIATION: HC00139 EHMN_ABBREVIATION: C00141
name: 3-methyl-2-oxobutanoate

http://identifiers.org/biomodels.db/MODEL1310110042#_3d89332f_bdee_4ae1_9a62_1d954576845c
is: B4E0V8
name: HAL
has only substance units: false
type: Species
constant: false
is: SBO:0000252
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:3034
boundary condition: true

metaM xol7ah c
type: Species
is: CHEBI:2290
is: HMDB06892
notes: FORMULA: C27H46O2 CHARGE: 0 INCHI: InChI=1S/C27H46O2/c1-17(2)7-6-8-18(3)21-9-10-22-25-23(12-14-27(21,22)5)26(4)13-11-20(28)15-19(26)16-24(25)29/h17-19,21-25,29H,6-16H2,1-5H3/t18-,19+,21-,22+,23+,24-,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01460 EHMN_ABBREVIATION: C05451
is: SBO:0000247
initial concentration: 1.0
initial amount: NaN
boundary condition: false
name: 7alpha-hydroxy-5beta-cholestan-3-one
has only substance units: false
constant: false

metaR HSAT4ly
kinetic law: MODEL1310110042#
is: SBO:0000185
name: heparan-glucosaminide N-acetyltransferase, lysosomal
reversible: false
product: MODEL1310110042#
type: Reaction
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Heparan sulfate degradation EC Number: 2.3.1.78 Confidence Level: 4 AUTHORS: PMID:15591281,PMID:8993162 NOTES:The proton is located in the lysosome since it comes from oxidation of the NH3+ group in glucosamine. This reaction assumes that the other proton liberated from glucosamine reduces coa in the cytosol. NCD
fast: false
reactant: MODEL1310110042#

metaR DHCR243r
reversible: false
product: MODEL1310110042#
reactant: MODEL1310110042#
is version of: http://identifiers.org/ec-code/1.3.1.72
kinetic law: MODEL1310110042#
fast: false
type: Reaction
is: SBO:0000176
name: 24-dehydrocholesterol reductase [Precursor]
is described by: ECO:0000134
notes: GENE_ASSOCIATION: (1718.1) SUBSYSTEM: Cholesterol metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:17984220,PMID:19520779,PMID:19520780 NOTES:lanosterol -> cholesterol pathway FAD known to be cofactor, other details missing NJ
modifier: MODEL1310110042#

metaR GLNCYSNaEx
fast: false
reversible: false
kinetic law: MODEL1310110042#
is described by: ECO:0000269
type: Reaction
is: SBO:0000185
notes: GENE_ASSOCIATION: (6510.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14530974 NOTES:SAB see Kanai and Hediger 2004 (2003), PMID 14530974
product: MODEL1310110042#
reactant: MODEL1310110042#
modifier: MODEL1310110042#
name: L-cysteine/L-glutamine Na-dependent exchange (Gln-L in)

metaR FAOXC101m
kinetic law: MODEL1310110042#
product: MODEL1310110042#
reactant: MODEL1310110042#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: isomerization(C10:1)m
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110042#_b316a65b_1f75_40ed_8a0e_d61d2d651ff4
boundary condition: true
type: Species
has part: Q9HCC0
is: SBO:0000297
initial amount: NaN
is encoded by: hsa:56922
is encoded by: hsa:64087
initial concentration: NaN
name: MCCC1:MCCC2
constant: false
has part: Q96RQ3
has only substance units: false

metaM ksii core2 deg6 l
type: Species
is: CHEBI:12936
name: keratan sulfate II (core 2-linked), degradation product 6
has only substance units: false
is: SBO:0000247
constant: false
boundary condition: false
initial amount: NaN
notes: FORMULA: C44H72N4O33SX CHARGE: -1
initial concentration: 1.0
is: HMDB00143

metaR MAN1PT2
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/2.7.7.13
notes: GENE_ASSOCIATION: (29926.2) or (29926.1) or (29925.2) or (29925.1) SUBSYSTEM: Fructose and mannose metabolism EC Number: 2.7.7.22 Confidence Level: 0 AUTHORS: NOTES:JLR
kinetic law: MODEL1310110042#
product: MODEL1310110042#
type: Reaction
is: SBO:0000176
reactant: MODEL1310110042#
reversible: false
modifier: MODEL1310110042#
fast: false
name: mannose-1-phosphate guanylyltransferase (GDP)

metaR EX ak2lgchol hs LPAREN e RPAREN
kinetic law: MODEL1310110042#
reactant: MODEL1310110042#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 1-alkyl 2-lysoglycerol 3-phosphocholine exchange
type: Reaction

metaM succoa m
has only substance units: false
initial concentration: 1.0
is: SBO:0000247
is: CHEBI:57292
constant: false
initial amount: NaN
notes: FORMULA: C25H35N7O19P3S CHARGE: -5 HEPATONET_1.0_ABBREVIATION: HC00093 EHMN_ABBREVIATION: C00091
name: Succinyl-CoA
boundary condition: false
is: HMDB01022
type: Species

http://identifiers.org/biomodels.db/MODEL1310110042#_e7038a74_f572_4d32_b9c9_dba1ba2e77a0
is: E5KSL6
is: SBO:0000252
has only substance units: false
constant: false
name: DGUOK
is encoded by: hsa:1716
boundary condition: true
initial concentration: NaN
initial amount: NaN
type: Species

metaR TYRCBOX
notes: GENE_ASSOCIATION: (1644.1) SUBSYSTEM: Tyrosine metabolism EC Number: 4.1.1.28 Confidence Level: 4 AUTHORS: PMID:6131938 NOTES:SAB KEGG also says EC 4.1.1.28
is: SBO:0000176
product: MODEL1310110042#
is version of: http://identifiers.org/ec-code/4.1.1.28
modifier: MODEL1310110042#
reversible: false
name: L-Tyrosine carboxy-lyase
type: Reaction
kinetic law: MODEL1310110042#
reactant: MODEL1310110042#
fast: false
is described by: ECO:0000134

metaR r2382
fast: false
reversible: false
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
reactant: MODEL1310110042#
kinetic law: MODEL1310110042#
is described by: ECO:0000000
product: MODEL1310110042#
modifier: MODEL1310110042#
notes: GENE_ASSOCIATION: (215.1) or (U52111.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172 NOTES:
type: Reaction
is: SBO:0000185

metaR RE3626M
notes: GENE_ASSOCIATION: (51.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.3.6 Confidence Level: 0 AUTHORS: PMID:11356164,PMID:7775433 NOTES:
type: Reaction
fast: false
product: MODEL1310110042#
is described by: ECO:0000000
reversible: false
is: SBO:0000176
kinetic law: MODEL1310110042#
reactant: MODEL1310110042#
modifier: MODEL1310110042#
is version of: http://identifiers.org/ec-code/1.3.3.6
name: RE3626

metaR SLDt
is: SBO:0000185
reactant: MODEL1310110042#
kinetic law: MODEL1310110042#
name: L-sulfolactate transport (cytosol to extracellular)
notes: GENE_ASSOCIATION: SUBSYSTEM: Methionine and cysteine metabolism EC Number: Confidence Level: 2 AUTHORS: PMID:15758220 NOTES:MM
fast: false
is described by: ECO:0000000
reversible: false
product: MODEL1310110042#
type: Reaction

metaM prostgi2 r
name: prostaglandin I2(1-)
is: SBO:0000247
notes: FORMULA: C20H31O5 CHARGE: -1 INCHI: InChI=1S/C20H32O5/c1-2-3-4-7-14(21)10-11-16-17-12-15(8-5-6-9-20(23)24)25-19(17)13-18(16)22/h8,10-11,14,16-19,21-22H,2-7,9,12-13H2,1H3,(H,23,24)/p-1/b11-10+,15-8-/t14-,16+,17+,18+,19-/m0/s1 EHMN_ABBREVIATION: C01312
boundary condition: false
has only substance units: false
initial amount: NaN
initial concentration: 1.0
is: CHEBI:57403
constant: false
is: HMDB01335
type: Species

metaM lnlncacrn c
notes: FORMULA: C25H43NO4 CHARGE: 0 INCHI: InChI=1/C25H43NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-25(29)30-23(26(2,3)4)21-22-24(27)28/h6-7,9-10,12-13,23H,5,8,11,14-22H2,1-4H3/b7-6-,10-9-,13-12-/t23-/m0/s1
name: alpha-linolenyl carnitine
initial amount: NaN
type: Species
constant: false
initial concentration: 1.0
has only substance units: false
boundary condition: false
is: HMDB06319
is: SBO:0000247

metaR SGPL12r
type: Reaction
reversible: false
name: Sphingosine-1-phosphate lyase
fast: false
is: SBO:0000176
is version of: http://identifiers.org/ec-code/4.1.2.27
reactant: MODEL1310110042#
kinetic law: MODEL1310110042#
notes: GENE_ASSOCIATION: (8879.1) SUBSYSTEM: Sphingolipid metabolism EC Number: 4.1.2.27 Confidence Level: 2 AUTHORS: PMID:11018465,PMID:14570870 NOTES:SGPL1 gene as per GeneCards states that hexadecanal is produced - the only way to do this and to maintain charge balance would be to have H2 gas as substrate - remarkably implausible. Due to lack of information to indicate otherwise, added water to breakdown components into ethamp and palmitate NJ
product: MODEL1310110042#
modifier: MODEL1310110042#
is described by: ECO:0000304

metaR DURIPP
fast: false
is: SBO:0000176
product: MODEL1310110042#
notes: GENE_ASSOCIATION: (4860.1) or (151531.1) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: PMID:11278417,PMID:12849978,PMID:6087295,PMID:9305963 NOTES:JLR
is described by: ECO:0000269
name: deoxyuridine phosphorylase
reactant: MODEL1310110042#
type: Reaction
reversible: true
is version of: http://identifiers.org/ec-code/2.4.2.1
is version of: http://identifiers.org/ec-code/2.4.2.3
kinetic law: MODEL1310110042#
modifier: MODEL1310110042#

http://identifiers.org/biomodels.db/MODEL1310110042#_f5b08d51_2b63_499c_9fe5_29387120783f
type: Species
initial amount: NaN
is encoded by: hsa:2585
name: GALK2
is: SBO:0000252
initial concentration: NaN
constant: false
boundary condition: true
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110042#_c2462547_7873_46b3_a2e8_3ed66bd57879
boundary condition: true
constant: false
is encoded by: hsa:111
has only substance units: false
type: Species
is: SBO:0000252
is: O95622
initial amount: NaN
name: ADCY5
initial concentration: NaN

metaR NACHEX9ly
kinetic law: MODEL1310110042#
is: SBO:0000176
notes: GENE_ASSOCIATION: (3073.1 and 3074.1) or (3074.1) or (3073.1) SUBSYSTEM: Chondroitin sulfate degradation EC Number: 3.2.1.52 Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12706724,PMID:8993162 NOTES:NCD
reversible: false
fast: false
modifier: MODEL1310110042#
is described by: ECO:0000000
product: MODEL1310110042#
name: beta-N-acetylhexosaminidase, lysosomal
reactant: MODEL1310110042#
type: Reaction
is version of: http://identifiers.org/ec-code/3.2.1.52

metaR AMPDA
type: Reaction
is described by: ECO:0000269
name: Adenosine monophosphate deaminase
notes: GENE_ASSOCIATION: (271.2) or (270.1) or (271.1) or (272.1) or (271.3) SUBSYSTEM: Nucleotide interconversion EC Number: 3.5.4.6 Confidence Level: 4 AUTHORS: PMID:1400401,PMID:2345176 NOTES:
modifier: MODEL1310110042#
reversible: false
reactant: MODEL1310110042#
fast: false
kinetic law: MODEL1310110042#
is version of: http://identifiers.org/ec-code/3.5.4.6
is: SBO:0000176
product: MODEL1310110042#

metaR r1816
kinetic law: MODEL1310110042#
fast: false
name: Y+LAT2 Utilized transport
product: MODEL1310110042#
reversible: false
is described by: ECO:0000000
modifier: MODEL1310110042#
is: SBO:0000185
reactant: MODEL1310110042#
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
type: Reaction

metaR SBTR
is version of: http://identifiers.org/ec-code/1.1.1.2
reversible: false
type: Reaction
is described by: ECO:0000269
is: SBO:0000176
modifier: MODEL1310110042#
reactant: MODEL1310110042#
kinetic law: MODEL1310110042#
product: MODEL1310110042#
fast: false
name: D-sorbitol reductase
is version of: http://identifiers.org/ec-code/1.1.1.21
notes: GENE_ASSOCIATION: (8574.1) or (10327.1) or (231.1) or (10327.2) SUBSYSTEM: Fructose and mannose metabolism EC Number: 1.1.1.21 Confidence Level: 4 AUTHORS: PMID:12071861,PMID:9823300 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110042#_02bdee3c_d49d_49cf_b089_69cc7a117ffa
constant: false
is: SBO:0000252
is: O75610
initial concentration: NaN
boundary condition: true
is encoded by: hsa:10637
has only substance units: false
type: Species
initial amount: NaN
name: LEFTY1

metaR r2385
product: MODEL1310110042#
is: SBO:0000185
is described by: ECO:0000000
reversible: false
type: Reaction
kinetic law: MODEL1310110042#
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
fast: false
modifier: MODEL1310110042#
notes: GENE_ASSOCIATION: (215.1) or (U52111.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172 NOTES:
reactant: MODEL1310110042#

metaR RE2998M
is: SBO:0000176
name: RE2998
is described by: ECO:0000000
fast: false
notes: GENE_ASSOCIATION: (51.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.3.6 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:7775433 NOTES:
product: MODEL1310110042#
kinetic law: MODEL1310110042#
type: Reaction
reactant: MODEL1310110042#
reversible: false
modifier: MODEL1310110042#
is version of: http://identifiers.org/ec-code/1.3.3.6

metaM glc D g
is: CHEBI:4167
initial amount: NaN
has only substance units: false
is: SBO:0000247
boundary condition: false
is: HMDB00122
constant: false
name: D-glucose
notes: FORMULA: C6H12O6 CHARGE: 0 INCHI: InChI=1S/C6H12O6/c7-1-2-3(8)4(9)5(10)6(11)12-2/h2-11H,1H2/t2-,3-,4+,5-,6?/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00040
initial concentration: 1.0
type: Species

metaM tddedi2coa m
boundary condition: false
is: SBO:0000247
notes: FORMULA: C33H50N7O17P3S CHARGE: -4
has only substance units: false
is: HMDB00792
name: trans2,6dodecadienoylcoa
is: C08277
initial concentration: 1.0
constant: false
type: Species
initial amount: NaN

metaM L2aadp c
initial amount: NaN
initial concentration: 1.0
type: Species
boundary condition: false
has only substance units: false
is: HMDB00510
constant: false
is: SBO:0000247
notes: FORMULA: C6H10NO4 CHARGE: -1 INCHI: InChI=1S/C6H11NO4/c7-4(6(10)11)2-1-3-5(8)9/h4H,1-3,7H2,(H,8,9)(H,10,11)/p-1/t4-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00599 EHMN_ABBREVIATION: C00956
is: CHEBI:58672
name: L-2-aminoadipate(1-)

http://identifiers.org/biomodels.db/MODEL1310110042#_a01de4a9_4917_4ace_8d52_5eb61f5570b4
has part: Q9UPY5
initial concentration: NaN
is encoded by: hsa:23657
type: Species
is: SBO:0000297
initial amount: NaN
name: SLC7A11:SLC3A2
boundary condition: true
has only substance units: false
constant: false

metaM fru e
has only substance units: false
is: CHEBI:15824
is: SBO:0000247
is: C00095
initial concentration: 1.0
constant: false
initial amount: NaN
boundary condition: false
name: D-Fructose
notes: FORMULA: C6H12O6 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00097 EHMN_ABBREVIATION: C00095
is: HMDB00660
type: Species

metaR EX pchol hs LPAREN e RPAREN
kinetic law: MODEL1310110042#
reactant: MODEL1310110042#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Phosphatidylcholine (homo sapiens) exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110042#_7e6b6c7d_f668_490f_9639_7d6418480753
has only substance units: false
is encoded by: hsa:5148
initial amount: NaN
type: Species
is: SBO:0000252
name: PDE6G
is: P18545
boundary condition: true
constant: false
initial concentration: NaN

metaR FAOXC24C22x
kinetic law: MODEL1310110042#
product: MODEL1310110042#
reactant: MODEL1310110042#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: Fatty acid beta oxidation(C24-->C22)x
type: Reaction

metaR PI45PLC
name: phosphatidylinositol 4,5-bisphosphate phospholipase C
is described by: ECO:0000000
modifier: MODEL1310110042#
is version of: http://identifiers.org/ec-code/3.1.4.11
reactant: MODEL1310110042#
reversible: false
notes: GENE_ASSOCIATION: (23236.2) or (5336.1) or (9651.1) or (113026.1) or (89869.1) or (84812.1) or (5330.1) or (5335.1) or (51196.1) or (5333.1) or (5332.2) or (5331.1) or (5335.2) or (5334.1) or (5332.1) or (257068.1) or (23236.1) or (23007.1) SUBSYSTEM: Inositol phosphate metabolism EC Number: 3.1.4.11 Confidence Level: 4 AUTHORS: PMID:10702670,PMID:10702683,PMID:10760467,PMID:11022047,PMID:11022048,PMID:11118617,PMID:12117804,PMID:12213492,PMID:12416999,PMID:13333955,PMID:15140260,PMID:1644792,PMID:2167438,PMID:7607669,PMID:7612006,PMID:7633416,PMID:7789993,PMID:7835906,PMID:7849701,PMID:7890667,PMID:8530101,PMID:9345909 NOTES:NCD
is: SBO:0000176
kinetic law: MODEL1310110042#
product: MODEL1310110042#
type: Reaction
fast: false

metaM icit c
name: Isocitrate
has only substance units: false
boundary condition: false
notes: FORMULA: C6H5O7 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00266 EHMN_ABBREVIATION: C00311
is: CHEBI:16087
initial concentration: 1.0
is: SBO:0000247
initial amount: NaN
type: Species
is: HMDB00193
is: C00311
constant: false

metaR GLYCLTtp
kinetic law: MODEL1310110042#
name: glycolate transport into peroxisome
product: MODEL1310110042#
is: SBO:0000185
reactant: MODEL1310110042#
is described by: ECO:0000000
reversible: false
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: PMID:15240345 NOTES:NCD
fast: false

metaR EX succ LPAREN e RPAREN
kinetic law: MODEL1310110042#
reactant: MODEL1310110042#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Succinate exchange
type: Reaction

metaM dhap x
boundary condition: false
is: http://identifiers.org/pubchem.compound/3411
is: SBO:0000247
initial concentration: 1.0
name: Dihydroxyacetone phosphate
is: C00111
is: HMDB01473
initial amount: NaN
has only substance units: false
is: CHEBI:57642
constant: false
type: Species

metaR H8TAer
reversible: false
name: H8 transamidase, endoplasmic reticulum
notes: GENE_ASSOCIATION: (10026.1) and (8733.1) and (128869.1) and (94005.1) and (51604.1) SUBSYSTEM: Phosphatidylinositol phosphate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:10727241,PMID:11483512,PMID:12802054,PMID:15632136,PMID:9356492,PMID:9468317 NOTES:EC 2.6.-.- NCD
is: SBO:0000176
product: MODEL1310110042#
kinetic law: MODEL1310110042#
fast: false
type: Reaction
modifier: MODEL1310110042#
is described by: ECO:0000000
reactant: MODEL1310110042#

metaR r2384
kinetic law: MODEL1310110042#
is described by: ECO:0000000
fast: false
notes: GENE_ASSOCIATION: (215.1) or (U52111.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172 NOTES:
reactant: MODEL1310110042#
type: Reaction
product: MODEL1310110042#
is: SBO:0000185
reversible: false
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
modifier: MODEL1310110042#

http://identifiers.org/biomodels.db/MODEL1310110042#_9c811134_de70_43b1_b536_407ff5f3a921
boundary condition: true
type: Species
is: P22234
has only substance units: false
constant: false
is: SBO:0000252
is encoded by: hsa:10606
initial concentration: NaN
name: PAICS
initial amount: NaN

metaR r0860
is version of: http://identifiers.org/ec-code/4.1.2.27
name: Utilized transport
product: MODEL1310110042#
notes: GENE_ASSOCIATION: (8879.1) SUBSYSTEM: Purine catabolism EC Number: Confidence Level: 0 AUTHORS: PMID:1459,PMID:14598172,PMID:18406340,PMID:8132483 NOTES:
fast: false
kinetic law: MODEL1310110042#
is described by: ECO:0000000
type: Reaction
modifier: MODEL1310110042#
reversible: true
is: SBO:0000185
reactant: MODEL1310110042#

metaR EX h2o2 LPAREN e RPAREN
kinetic law: MODEL1310110042#
reactant: MODEL1310110042#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Hydrogen peroxide exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110042#_ce9f464b_6084_42e2_a7d1_c0228ad0d722
constant: false
name: GCNT4
boundary condition: true
initial concentration: NaN
has only substance units: false
type: Species
is encoded by: hsa:51301
is: SBO:0000252
initial amount: NaN
is: Q9P109

metaR AMPTASECGe
kinetic law: MODEL1310110042#
product: MODEL1310110042#
type: Reaction
is described by: ECO:0000269
reactant: MODEL1310110042#
is version of: http://identifiers.org/ec-code/3.4.11.2
name: alanyl aminopeptidase (cys-gly) (e)
reversible: false
modifier: MODEL1310110042#
fast: false
is: SBO:0000176
notes: GENE_ASSOCIATION: (290.1) SUBSYSTEM: Glutathione metabolism EC Number: 3.4.11.2 Confidence Level: 4 AUTHORS: PMID:6126478 NOTES:SAB. rat lumen renal proximal tubule preparation cysteinylglycine metabolism measured due to aminopeptidase M (=N); the annotation in BiGG of strong biochemical evidence in a textbook could not be found in the Google Books version search of this book; intensively sought for human metabolism; human metabolism is likely though not proven directly

metaR FOLt2le
name: folate transport via anion exchange
kinetic law: MODEL1310110042#
type: Reaction
fast: false
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
product: MODEL1310110042#
reactant: MODEL1310110042#
is: SBO:0000185
is described by: ECO:0000134

metaR RTOTAL3t
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:14598172 NOTES:
kinetic law: MODEL1310110042#
name: RTOTAL3 transport
fast: false
type: Reaction
reactant: MODEL1310110042#
product: MODEL1310110042#
reversible: true
is: SBO:0000185

metaR RE3241R
product: MODEL1310110042#
type: Reaction
is: SBO:0000176
notes: GENE_ASSOCIATION: (64834.1) SUBSYSTEM: Fatty acid synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:10970790 NOTES:
name: RE3241
fast: false
is described by: ECO:0000000
reversible: false
reactant: MODEL1310110042#
kinetic law: MODEL1310110042#
modifier: MODEL1310110042#

metaR FAOXC12C12OHm
kinetic law: MODEL1310110042#
product: MODEL1310110042#
reactant: MODEL1310110042#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C12-->OHC12)m
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110042#_c9f6ba8d_4c48_4048_8fe7_30a347075f22
constant: false
name: COL4A3BP
is: Q9Y5P4
is encoded by: hsa:10087
boundary condition: true
type: Species
initial concentration: NaN
is: SBO:0000252
initial amount: NaN
has only substance units: false

metaM val L m
type: Species
is: SBO:0000247
name: L-valine
has only substance units: false
constant: false
initial concentration: 1.0
boundary condition: false
is: CHEBI:16414
initial amount: NaN
notes: FORMULA: C5H11NO2 CHARGE: 0 INCHI: InChI=1S/C5H11NO2/c1-3(2)4(6)5(7)8/h3-4H,6H2,1-2H3,(H,7,8)/t4-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00174
is: HMDB00883

http://identifiers.org/biomodels.db/MODEL1310110042#_238a6588_7fe6_44d3_8384_e4e5e69dab59
initial amount: NaN
boundary condition: true
constant: false
initial concentration: NaN
is: SBO:0000252
name: ARSB
has only substance units: false
is encoded by: hsa:411
type: Species
is: A8K4A0

metaR S4TASE3ly
kinetic law: MODEL1310110042#
fast: false
type: Reaction
reversible: true
notes: GENE_ASSOCIATION: (411.1) or (411.2) SUBSYSTEM: Chondroitin sulfate degradation EC Number: 3.1.6.12 Confidence Level: 4 AUTHORS: PMID:1968043,PMID:2303452 NOTES:NCD
name: N-acetylgalactosamine-4-sulfatase, lysosomal
is version of: http://identifiers.org/ec-code/3.1.6.12
is: SBO:0000176
modifier: MODEL1310110042#
product: MODEL1310110042#
reactant: MODEL1310110042#
is described by: ECO:0000000

metaR EX ade LPAREN e RPAREN
kinetic law: MODEL1310110042#
reactant: MODEL1310110042#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Adenine exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110042#_ed823565_1254_4123_ac23_fc4c93b2f409
constant: false
type: Species
boundary condition: true
initial amount: NaN
is: SBO:0000252
name: _NM_001929_1_c
initial concentration: NaN
has only substance units: false
is encoded by: hsa:NM 001929

metaR ARGATB0tc
kinetic law: MODEL1310110042#
product: MODEL1310110042#
reactant: MODEL1310110042#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of L-Arginine into the intestinal cells by ATB0 transporter
type: Reaction

metaM air c
is: CHEBI:58592
initial amount: NaN
notes: FORMULA: C8H12N3O7P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC01108 EHMN_ABBREVIATION: C03373
initial concentration: 1.0
name: 5-amino-1-(5-phospho-D-ribosyl)imidazole
type: Species
has only substance units: false
boundary condition: false
is: HMDB01235
is: C03373
constant: false
is: SBO:0000247

metaR SUBERCACT
kinetic law: MODEL1310110042#
product: MODEL1310110042#
reactant: MODEL1310110042#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: transport of suberyl carnitine into cytosol
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110042#_b21626f7_af34_4f5c_ac30_1353a1f22aaa
is: SBO:0000252
is: P40394
name: ADH7
initial amount: NaN
is encoded by: hsa:131
type: Species
initial concentration: NaN
boundary condition: true
has only substance units: false
constant: false

http://identifiers.org/biomodels.db/MODEL1310110042#_6ef8e562_ead7_47e8_a94f_097971ada547
boundary condition: true
constant: false
initial concentration: NaN
has only substance units: false
name: SLC7A6
type: Species
initial amount: NaN
is: SBO:0000252
is encoded by: hsa:9057
is: Q92536

metaM dha e
has only substance units: false
notes: FORMULA: C3H6O3 CHARGE: 0 INCHI: InChI=1S/C3H6O3/c4-1-3(6)2-5/h4-5H,1-2H2 HEPATONET_1.0_ABBREVIATION: HC00175 EHMN_ABBREVIATION: C00184
is: HMDB01882
is: SBO:0000247
type: Species
name: glycerone
is: CHEBI:16016
initial amount: NaN
constant: false
initial concentration: 1.0
boundary condition: false

metaM retn e
type: Species
initial amount: NaN
constant: false
notes: FORMULA: C20H27O2 CHARGE: -1 INCHI: InChI=1S/C20H28O2/c1-15(8-6-9-16(2)14-19(21)22)11-12-18-17(3)10-7-13-20(18,4)5/h6,8-9,11-12,14H,7,10,13H2,1-5H3,(H,21,22)/p-1/b9-6+,12-11+,15-8+,16-14+ HEPATONET_1.0_ABBREVIATION: HC00532 EHMN_ABBREVIATION: C00777
boundary condition: false
is: SBO:0000247
is: HMDB01852
initial concentration: 1.0
name: all-trans-retinoate
has only substance units: false
is: CHEBI:35291

metaR FAOXC61m
kinetic law: MODEL1310110042#
product: MODEL1310110042#
reactant: MODEL1310110042#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: isomerization(C6:1)m
type: Reaction

metaM udpg c
boundary condition: false
constant: false
has only substance units: false
is: SBO:0000247
is: C00029
type: Species
notes: FORMULA: C15H22N2O17P2 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00038 EHMN_ABBREVIATION: C00029
is: HMDB00286
initial amount: NaN
initial concentration: 1.0
is: CHEBI:58367
name: UDPglucose

http://identifiers.org/biomodels.db/MODEL1310110042#_893599a6_f2ec_4e34_8a23_afac2f2fed23
boundary condition: true
type: Species
is: SBO:0000252
constant: false
is encoded by: hsa:55753
initial amount: NaN
name: OGDHL
is: Q9ULD0
initial concentration: NaN
has only substance units: false

metaR FAOXC204184m
notes: GENE_ASSOCIATION: (35.1) or (34.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.74 Confidence Level: 4 AUTHORS: NOTES:_1 rounds of beta ox c20:4 -> c18:4 4 step FAO lumped for 2 rounds also includes EC 1.1.1.35, 1.1.1.211, 1.3.3.6, 4.2.1.17, 4.2.1.74 NJ
reactant: MODEL1310110042#
type: Reaction
is: SBO:0000176
name: Beta oxidation fatty acid
kinetic law: MODEL1310110042#
modifier: MODEL1310110042#
product: MODEL1310110042#
is version of: http://identifiers.org/ec-code/1.3.99.3
is version of: http://identifiers.org/ec-code/1.3.8.1
fast: false
is described by: ECO:0000000
reversible: false

metaR DLNLCGCRNt
is described by: ECO:0000000
fast: false
product: MODEL1310110042#
reactant: MODEL1310110042#
name: transport into the mitochondria (carnitine)
kinetic law: MODEL1310110042#
type: Reaction
notes: GENE_ASSOCIATION: (788.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: NOTES:NJ
is: SBO:0000185
modifier: MODEL1310110042#
reversible: false

metaR PTCRTD
product: MODEL1310110042#
name: diffusion of putriscine into the endothelial cells
type: Reaction
is: SBO:0000185
fast: false
is described by: ECO:0000134
kinetic law: MODEL1310110042#
reversible: true
reactant: MODEL1310110042#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID: 9505881, PMID: 11564949 NOTES:putriscine uptake by the cells via passive diffusion, reported to be more rapid at the basolateral side.

metaR ECOAH9m
is described by: ECO:0000304
fast: false
type: Reaction
notes: GENE_ASSOCIATION: (1892.1) or (3030.1) and (3032.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 4.2.1.17 Confidence Level: 2 AUTHORS: PMID:9073515 NOTES:MM. based on assigned short chain enoyl-CoA hydratase activity
is version of: http://identifiers.org/ec-code/4.2.1.17
is: SBO:0000176
reversible: true
reactant: MODEL1310110042#
kinetic law: MODEL1310110042#
modifier: MODEL1310110042#
name: 2-Methylprop-2-enoyl-CoA (2-Methylbut-2-enoyl-CoA), mitochondrial
is version of: http://identifiers.org/ec-code/2.3.1.16
product: MODEL1310110042#

metaR LDH D
modifier: MODEL1310110042#
name: D-lactate dehydrogenase
reversible: true
type: Reaction
is version of: http://identifiers.org/ec-code/1.1.2.4
product: MODEL1310110042#
kinetic law: MODEL1310110042#
fast: false
is described by: ECO:0000304
is: SBO:0000176
reactant: MODEL1310110042#
notes: GENE_ASSOCIATION: (197257.1) or (197257.2) SUBSYSTEM: Pyruvate metabolism EC Number: 1.1.1.28 Confidence Level: 2 AUTHORS: PMID:11955284,PMID:12127981 NOTES:See also LDL_L. D-lactate metabolism measured in rat mitochondria; probably depend on D-LDH activity in matrix plus transport activity across mitochondrial membrane; putative human D-LDH cloned ; D-lactate formed in nanomolar concentrations via the methylglyoxal pathway; D- -hydroxy acid dehydrogenase (EC 1.1.99.6)

metaR r1731
type: Reaction
reactant: MODEL1310110042#
product: MODEL1310110042#
fast: false
name: Y+LAT2 Utilized transport
kinetic law: MODEL1310110042#
is described by: ECO:0000000
reversible: false
is: SBO:0000185
modifier: MODEL1310110042#
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:

metaR SACCD4m
modifier: MODEL1310110042#
name: saccharopine dehydrogenase (NAD, L-glutamate forming), mitochondrial
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (10157.1) SUBSYSTEM: Lysine metabolism EC Number: 1.5.1.10 Confidence Level: 4 AUTHORS: PMID:10775527 NOTES:MM
fast: false
reversible: false
product: MODEL1310110042#
is version of: http://identifiers.org/ec-code/1.5.1.8
reactant: MODEL1310110042#
kinetic law: MODEL1310110042#
is: SBO:0000176
type: Reaction

metaM succoa c
initial amount: NaN
type: Species
is: SBO:0000247
has only substance units: false
is: HMDB01022
constant: false
notes: FORMULA: C25H35N7O19P3S CHARGE: -5
initial concentration: 1.0
boundary condition: false
name: Succinyl-CoA

metaM thmmp c
constant: false
boundary condition: false
is: C01081
initial concentration: 1.0
has only substance units: false
notes: FORMULA: C12H16N4O4PS CHARGE: -1 EHMN_ABBREVIATION: C01081
is: CHEBI:37575
name: Thiamin monophosphate
initial amount: NaN
is: SBO:0000247
is: HMDB02666
type: Species

metaM ahcys e
is: HMDB00939
has only substance units: false
constant: false
notes: FORMULA: C14H20N6O5S CHARGE: 0
initial amount: NaN
is: SBO:0000247
boundary condition: false
type: Species
is: C00021
initial concentration: 1.0
name: S-Adenosyl-L-homocysteine
is: CHEBI:16680

metaM limnen c
constant: false
has only substance units: false
initial amount: NaN
is: HMDB03375
type: Species
boundary condition: false
is: SBO:0000247
name: limonene
initial concentration: 1.0
notes: FORMULA: C10H16 CHARGE: 0 INCHI: InChI=1S/C10H16/c1-8(2)10-6-4-9(3)5-7-10/h4,10H,1,5-7H2,2-3H3
is: CHEBI:15384

http://identifiers.org/biomodels.db/MODEL1310110042#_63844299_f3ac_4d9d_9937_32c307b11e27
is encoded by: hsa:3421
boundary condition: true
name: IDH3G
has only substance units: false
initial amount: NaN
is: SBO:0000252
type: Species
initial concentration: NaN
is: P51553
constant: false

metaR MG1er
modifier: MODEL1310110042#
reversible: false
type: Reaction
is described by: ECO:0000000
name: mannosyl-oligosaccharide glucosidase, endoplasmic reticulum
fast: false
kinetic law: MODEL1310110042#
is version of: http://identifiers.org/ec-code/3.2.1.106
is: SBO:0000176
notes: GENE_ASSOCIATION: (7841.1) SUBSYSTEM: N-glycan synthesis EC Number: 3.2.1.106 Confidence Level: 0 AUTHORS: NOTES:NCD
reactant: MODEL1310110042#
product: MODEL1310110042#

metaR r0653
reversible: false
is described by: ECO:0000000
reactant: MODEL1310110042#
name: myristoyl-CoA:acetylCoA C-myristoyltransferase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:2.3.1.16
is: SBO:0000176
product: MODEL1310110042#
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.16 Confidence Level: 0 AUTHORS: PMID:10706581,PMID:1121274,PMID:1679347,PMID:3194209,PMID:6378901,PMID:8241273 NOTES:
type: Reaction
kinetic law: MODEL1310110042#
fast: false

metaR 4HBZFm
reversible: false
is described by: ECO:0000000
type: Reaction
name: 4-hydroxybenzoate formation
is: SBO:0000176
fast: false
reactant: MODEL1310110042#
product: MODEL1310110042#
notes: GENE_ASSOCIATION: SUBSYSTEM: Ubiquinone synthesis EC Number: Confidence Level: 2 AUTHORS: PMID:11583838,PMID:12232327 NOTES:IT reaction involved in formation of 4-hydroxybenzoate from tyrosine.
kinetic law: MODEL1310110042#

http://identifiers.org/biomodels.db/MODEL1310110042#_54f7cf81_2076_4d0a_9fd3_a0c4c6311533
initial concentration: NaN
is: Q8TE54
constant: false
initial amount: NaN
boundary condition: true
has only substance units: false
name: SLC26A7
type: Species
is: SBO:0000252
is encoded by: hsa:115111

http://identifiers.org/biomodels.db/MODEL1310110042#_7a78e460_ae4a_4d2b_b7d0_49688a652996
initial concentration: NaN
is: Q674R7
name: ATG9B
boundary condition: true
initial amount: NaN
is: SBO:0000252
is encoded by: hsa:285973
has only substance units: false
constant: false
type: Species

metaR TXASr
reversible: false
modifier: MODEL1310110042#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/5.3.99.5
type: Reaction
notes: GENE_ASSOCIATION: (6916.1) SUBSYSTEM: Eicosanoid metabolism EC Number: 5.3.99.5 Confidence Level: 0 AUTHORS: PMID:10903770,PMID:2491846,PMID:7811713 NOTES:NJ
fast: false
is described by: ECO:0000134
kinetic law: MODEL1310110042#
name: Thromboxane-A synthase
reactant: MODEL1310110042#
product: MODEL1310110042#

http://identifiers.org/biomodels.db/MODEL1310110042#_aef77092_2a27_4ef6_b033_b80b3b8aab5b
name: ACSS2
initial concentration: NaN
boundary condition: true
initial amount: NaN
type: Species
has only substance units: false
is: SBO:0000252
is encoded by: hsa:55902
is: Q5QPH3
constant: false

metaM hdca c
has only substance units: false
name: palmitate
is: HMDB00220
initial concentration: 1.0
notes: FORMULA: C16H31O2 CHARGE: -1 INCHI: InChI=1S/C16H32O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16(17)18/h2-15H2,1H3,(H,17,18)/p-1 HEPATONET_1.0_ABBREVIATION: HC00226 EHMN_ABBREVIATION: C00249
initial amount: NaN
type: Species
constant: false
boundary condition: false
is: SBO:0000247
is: CHEBI:7896

http://identifiers.org/biomodels.db/MODEL1310110042#_079d5bef_484b_4307_b2d5_ba5d50a953c6
is: Q71UM8
type: Species
initial concentration: NaN
is: SBO:0000252
has only substance units: false
is encoded by: hsa:108
name: ADCY2
constant: false
boundary condition: true
initial amount: NaN

metaR r0656
is described by: ECO:0000000
reactant: MODEL1310110042#
name: 3-methylbutanoyl-CoA:enzyme N6-(dihydrolipoyl)lysine S-(3-methylbutanoyl)transferase Valine, leucine and isoleucine degradation EC:2.3.1.168
is: SBO:0000176
kinetic law: MODEL1310110042#
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 2.3.1.168 Confidence Level: 0 AUTHORS: PMID:1943690 NOTES:
product: MODEL1310110042#
type: Reaction
reversible: false
fast: false

metaM arachd x
is: HMDB01043
type: Species
initial concentration: 1.0
boundary condition: false
constant: false
is: CHEBI:32395
initial amount: NaN
name: arachidonate
is: SBO:0000247
notes: FORMULA: C20H31O2 CHARGE: -1 INCHI: InChI=1S/C20H32O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20(21)22/h6-7,9-10,12-13,15-16H,2-5,8,11,14,17-19H2,1H3,(H,21,22)/p-1/b7-6-,10-9-,13-12-,16-15- HEPATONET_1.0_ABBREVIATION: HC00202 EHMN_ABBREVIATION: C00219
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110042#_cc5a373d_5bab_49ae_a0f2_dcaac99c5594
is: SBO:0000252
type: Species
constant: false
name: DPM2
initial concentration: NaN
has only substance units: false
is encoded by: hsa:8818
is: O94777
initial amount: NaN
boundary condition: true

metaM retfa c
is: HMDB00305
is: SBO:0000247
type: Species
boundary condition: false
is: CHEBI:50211
has only substance units: false
initial amount: NaN
constant: false
name: fatty acid retinol
notes: FORMULA: C20H29OFULLR2CO CHARGE: 0
initial concentration: 1.0

metaR ACACT10m
notes: GENE_ASSOCIATION: (38.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 2.3.1.9 Confidence Level: 4 AUTHORS: PMID:676035 NOTES:MM. 2-Methyl-3-acetoacetyl-CoA excreted into urine for patients with disease deficiency
product: MODEL1310110042#
is described by: ECO:0000134
reactant: MODEL1310110042#
modifier: MODEL1310110042#
is: SBO:0000176
type: Reaction
fast: false
reversible: true
name: acetyl-CoA C-acetyltransferase, mitochondrial
kinetic law: MODEL1310110042#
is version of: http://identifiers.org/ec-code/2.3.1.9

http://identifiers.org/biomodels.db/MODEL1310110042#_c253f746_c28f_4499_8b37_840ad9fae8c6
type: Species
has only substance units: false
is: SBO:0000252
constant: false
initial concentration: NaN
name: SLC6A2
is encoded by: hsa:6530
boundary condition: true
initial amount: NaN
is: Q96KH8

metaR SCP21x
product: MODEL1310110042#
notes: GENE_ASSOCIATION: (6342.1) SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 4 AUTHORS: PMID:1703300 NOTES:intracellular transport, mechanism details not presently known NJ
name: Sterol carrier protein 2
is described by: ECO:0000269
reversible: true
reactant: MODEL1310110042#
kinetic law: MODEL1310110042#
type: Reaction
fast: false
is: SBO:0000185
is version of: http://identifiers.org/ec-code/2.3.1.176
modifier: MODEL1310110042#

metaR S2TASE1ly
is described by: ECO:0000000
product: MODEL1310110042#
is version of: http://identifiers.org/ec-code/3.1.6.13
fast: false
modifier: MODEL1310110042#
notes: GENE_ASSOCIATION: (3423.1) or (3423.2) SUBSYSTEM: Heparan sulfate degradation EC Number: 3.1.6.13 Confidence Level: 4 AUTHORS: PMID:2122463,PMID:8244397,PMID:8530090,PMID:8993162 NOTES:NCD
name: iduronate-2-sulfatase, lysosomal
is: SBO:0000176
kinetic law: MODEL1310110042#
type: Reaction
reactant: MODEL1310110042#
reversible: false

metaR LTC4CP
name: Leukotriene C4 carboxypeptidase
fast: false
kinetic law: MODEL1310110042#
is: SBO:0000176
type: Reaction
product: MODEL1310110042#
reactant: MODEL1310110042#
notes: GENE_ASSOCIATION: SUBSYSTEM: Eicosanoid metabolism EC Number: 2.3.2.2 Confidence Level: 2 AUTHORS: PMID:12729612 NOTES:Converts leukotriene C4 (LTC4) to leukotriene F4 (LTF4). NJ
is described by: ECO:0000000
reversible: true

metaM xol7aone r
is: HMDB01993
name: 7alpha-hydroxycholest-4-en-3-one
initial concentration: 1.0
initial amount: NaN
boundary condition: false
constant: false
type: Species
is: SBO:0000247
has only substance units: false
notes: FORMULA: C27H44O2 CHARGE: 0 INCHI: InChI=1S/C27H44O2/c1-17(2)7-6-8-18(3)21-9-10-22-25-23(12-14-27(21,22)5)26(4)13-11-20(28)15-19(26)16-24(25)29/h15,17-18,21-25,29H,6-14,16H2,1-5H3/t18-,21-,22+,23+,24-,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01464 EHMN_ABBREVIATION: C05455
is: CHEBI:17899

metaR r1733
name: Y+LAT2 Utilized transport
modifier: MODEL1310110042#
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
product: MODEL1310110042#
kinetic law: MODEL1310110042#
reactant: MODEL1310110042#
reversible: false
is described by: ECO:0000000
fast: false
is: SBO:0000185
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110042#_a89e9a69_a03b_4b00_841e_28c5e93269bb
is: SBO:0000252
has only substance units: false
type: Species
name: _BE042354_1_m
initial amount: NaN
initial concentration: NaN
constant: false
is encoded by: hsa:BE042354
boundary condition: true

metaM 3odcoa x
type: Species
notes: FORMULA: C31H48N7O18P3S CHARGE: -4 INCHI: InChI=1S/C31H52N7O18P3S/c1-4-5-6-7-8-9-19(39)14-22(41)60-13-12-33-21(40)10-11-34-29(44)26(43)31(2,3)16-53-59(50,51)56-58(48,49)52-15-20-25(55-57(45,46)47)24(42)30(54-20)38-18-37-23-27(32)35-17-36-28(23)38/h17-18,20,24-26,30,42-43H,4-16H2,1-3H3,(H,33,40)(H,34,44)(H,48,49)(H,50,51)(H2,32,35,36)(H2,45,46,47)/t20-,24-,25-,26+,30-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01404 EHMN_ABBREVIATION: C05265
constant: false
is: HMDB03939
name: 3-Oxodecanoyl-CoA
is: CHEBI:28528
boundary condition: false
initial concentration: 1.0
initial amount: NaN
is: SBO:0000247
has only substance units: false

metaM orot c
is: HMDB00226
type: Species
has only substance units: false
is: CHEBI:30839
initial concentration: 1.0
notes: FORMULA: C5H3N2O4 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00256 EHMN_ABBREVIATION: C00295
boundary condition: false
is: SBO:0000247
initial amount: NaN
constant: false
is: C00295
name: Orotate

metaM gthox c
is: CHEBI:58297
initial amount: NaN
type: Species
initial concentration: 1.0
notes: FORMULA: C20H30N6O12S2 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00125 EHMN_ABBREVIATION: C00127
is: C00127
has only substance units: false
name: Oxidized glutathione
constant: false
boundary condition: false
is: SBO:0000247
is: HMDB03337

metaR NDP7ex
name: nucleoside-diphosphatase (UDP), extracellular
fast: false
notes: GENE_ASSOCIATION: (124583.1) SUBSYSTEM: Nucleotide interconversion EC Number: 3.6.1.6 Confidence Level: 4 AUTHORS: PMID:12600208 NOTES:
is version of: http://identifiers.org/ec-code/3.6.1.6
is: SBO:0000176
type: Reaction
kinetic law: MODEL1310110042#
reactant: MODEL1310110042#
modifier: MODEL1310110042#
product: MODEL1310110042#
is described by: ECO:0000269
reversible: false

metaM chol n
constant: false
initial amount: NaN
boundary condition: false
notes: FORMULA: C5H14NO CHARGE: 1 INCHI: InChI=1S/C5H14NO/c1-6(2,3)4-5-7/h7H,4-5H2,1-3H3/q+1 HEPATONET_1.0_ABBREVIATION: HC00112 EHMN_ABBREVIATION: C00114
has only substance units: false
name: choline
type: Species
is: SBO:0000247
is: HMDB00097
initial concentration: 1.0
is: CHEBI:15354

metaM c4crn x
constant: false
is: SBO:0000247
has only substance units: false
is: http://identifiers.org/pubchem.compound/213144
initial concentration: 1.0
type: Species
notes: FORMULA: C11H21NO4 CHARGE: 0
is: C02862
boundary condition: false
name: butyryl carnitine
is: HMDB02013
initial amount: NaN

metaR r0655
is described by: ECO:0000000
modifier: MODEL1310110042#
is: SBO:0000176
fast: false
is version of: http://identifiers.org/ec-code/1.5.1.2
reactant: MODEL1310110042#
notes: GENE_ASSOCIATION: (10637.1) or (5831.1) or (29920.1) or (65263.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 1.3.99.10 Confidence Level: 0 AUTHORS: PMID:3597357,PMID:9214289 NOTES:
kinetic law: MODEL1310110042#
type: Reaction
product: MODEL1310110042#
reversible: true
name: 3-Methylbutanoyl-CoA:(acceptor) 2,3-oxidoreductase Valine, leucine and isoleucine degradation EC:1.3.99.10

metaM oaa m
is: HMDB00223
is: C00036
is: SBO:0000247
has only substance units: false
initial amount: NaN
initial concentration: 1.0
type: Species
boundary condition: false
constant: false
is: CHEBI:16452
name: Oxaloacetate
notes: FORMULA: C4H2O5 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00044 EHMN_ABBREVIATION: C00036

metaR GLYtp
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: PMID:15240345 NOTES:TDV
kinetic law: MODEL1310110042#
reactant: MODEL1310110042#
is: SBO:0000185
name: glycine passive transport to peroxisome
reversible: true
type: Reaction
product: MODEL1310110042#
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110042#_cd086dfa_2de4_49ea_96ad_0af57152fd94
type: Species
name: AK4
boundary condition: true
initial concentration: NaN
constant: false
is encoded by: hsa:205
is: SBO:0000252
has only substance units: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110042#_5fe0632e_176d_488c_94b3_841d0fce1a9b
has only substance units: false
is: SBO:0000297
has part: P18545
is encoded by: hsa:5148
name: PDE6A:PDE6C:PDE6D:PDE6G:PDE6B
boundary condition: true
initial concentration: NaN
has part: O43924
type: Species
is encoded by: hsa:5147
initial amount: NaN
constant: false

metaM 3hddcoa m
initial amount: NaN
has only substance units: false
is: SBO:0000247
is: C05279
boundary condition: false
type: Species
is: HMDB11123
name: (S)-3-Hydroxydodecanoyl-CoA
constant: false
initial concentration: 1.0
notes: FORMULA: C33H54N7O18P3S CHARGE: -4

metaM 10fthf5glu e
has only substance units: false
initial amount: NaN
is: CHEBI:57454
is: SBO:0000247
boundary condition: false
is: HMDB00972
constant: false
notes: FORMULA: C40H45N11O19 CHARGE: -6
name: 10-formyltetrahydrofolate-[Glu](5)
type: Species
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110042#_29e41843_0367_4f65_bba7_8404c04a4205
name: GGT1
initial concentration: NaN
is: SBO:0000252
has only substance units: false
type: Species
constant: false
is encoded by: hsa:2678
initial amount: NaN
boundary condition: true

metaR ASNSERNaEx
reactant: MODEL1310110042#
type: Reaction
notes: GENE_ASSOCIATION: (6510.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14530974 NOTES:SAB see Kanai and Hediger 2004 (2003), PMID 14530974
is: SBO:0000185
kinetic law: MODEL1310110042#
modifier: MODEL1310110042#
is described by: ECO:0000269
reversible: false
fast: false
name: L-serine/L-asparagine Na-dependent exchange (Asn-L in)
product: MODEL1310110042#

metaM elaidcrn c
initial amount: NaN
type: Species
initial concentration: 1.0
notes: FORMULA: C25H47NO4 CHARGE: 0 INCHI: InChI=1/C25H47NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-25(29)30-23(21-24(27)28)22-26(2,3)4/h12-13,23H,5-11,14-22H2,1-4H3/b13-12+
has only substance units: false
is: SBO:0000247
constant: false
is: HMDB06464
name: Elaidic carnitine
boundary condition: false

metaR HISSNAT5tc
kinetic law: MODEL1310110042#
product: MODEL1310110042#
reactant: MODEL1310110042#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: Transport of L-Histidine into the cell coupled with co-transport with Sodium and counter transport with proton by SNAT5 transporter.
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110042#_5583076b_d9b6_422d_bf7f_565ead867573
is: P22680
is: SBO:0000252
initial concentration: NaN
initial amount: NaN
type: Species
is encoded by: hsa:1581
has only substance units: false
constant: false
name: CYP7A1
boundary condition: true

metaM cs e deg3 l
constant: false
notes: FORMULA: C37H53NO44S4 CHARGE: -6
has only substance units: false
is: HMDB00127
initial amount: NaN
boundary condition: false
name: chondroitin sulfate E (GalNAc4,6diS-GlcA), degradation product 3
is: SBO:0000247
type: Species
initial concentration: 1.0
is: CHEBI:15748

metaM udpgal c
boundary condition: false
has only substance units: false
is: CHEBI:58439
name: UDP-D-galactose(2-)
is: HMDB00302
type: Species
constant: false
initial concentration: 1.0
initial amount: NaN
is: SBO:0000247
notes: FORMULA: C15H22N2O17P2 CHARGE: -2 INCHI: InChI=1S/C15H24N2O17P2/c18-3-5-8(20)10(22)12(24)14(32-5)33-36(28,29)34-35(26,27)30-4-6-9(21)11(23)13(31-6)17-2-1-7(19)16-15(17)25/h1-2,5-6,8-14,18,20-24H,3-4H2,(H,26,27)(H,28,29)(H,16,19,25)/p-2/t5-,6-,8+,9-,10+,11-,12-,13-,14?/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00057 EHMN_ABBREVIATION: C00052

http://identifiers.org/biomodels.db/MODEL1310110042#_29ff8e40_985a_407f_9523_e439f4b3ec07
initial amount: NaN
type: Species
has only substance units: false
is encoded by: hsa:217
initial concentration: NaN
name: ALDH2
is: P05091
is: SBO:0000252
boundary condition: true
constant: false

metaR EX c51crn
kinetic law: MODEL1310110042#
reactant: MODEL1310110042#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for tiglyl carnitine
type: Reaction

metaM fe2 c
is: C00023
is: CHEBI:29033
initial amount: NaN
has only substance units: false
type: Species
name: Fe2+
notes: FORMULA: Fe CHARGE: 2 HEPATONET_1.0_ABBREVIATION: HC01846 EHMN_ABBREVIATION: C00023
is: SBO:0000247
initial concentration: 1.0
constant: false
is: HMDB00692
boundary condition: false

metaR NDPK1m
is described by: ECO:0000254
name: nucleoside-diphosphate kinase (ATP:GDP), mitochondrial
fast: false
modifier: MODEL1310110042#
reactant: MODEL1310110042#
reversible: true
product: MODEL1310110042#
kinetic law: MODEL1310110042#
is version of: http://identifiers.org/ec-code/2.7.4.6
notes: GENE_ASSOCIATION: (4833.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.6 Confidence Level: 2 AUTHORS: PMID:9099850 NOTES:Many nucleoside diphosphates (eight described) can act as acceptors. While many ribo- and deoxyribonucleoside triphosphates can act as donors, only ATP is chosen as a donor to minimize the number of total reactions.
is: SBO:0000176
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110042#_7934f2e7_a465_4f88_9d18_12a20d744a5f
initial concentration: NaN
initial amount: NaN
type: Species
is encoded by: hsa:286297
boundary condition: true
constant: false
name: _286297_1_c
has only substance units: false
is: SBO:0000252

metaM hdca e
boundary condition: false
notes: FORMULA: C16H31O2 CHARGE: -1
is: C00249
has only substance units: false
type: Species
initial amount: NaN
is: HMDB00220
name: Hexadecanoate (n-C16:0)
constant: false
initial concentration: 1.0
is: CHEBI:0
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110042#_370b1029_3794_4e08_b413_e97e1cbc0f31
boundary condition: true
is: SBO:0000252
constant: false
initial amount: NaN
name: _BC005314_1_x
initial concentration: NaN
type: Species
is encoded by: hsa:BC005314
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110042#_0bb44bc4_4099_4b33_aff5_38e51bfea6af
name: OGDH
is: SBO:0000252
is: Q02218
initial concentration: NaN
is encoded by: hsa:4967
type: Species
has only substance units: false
constant: false
boundary condition: true
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110042#_80ed8695_4ee1_44b4_8c22_f48d888b5a38
boundary condition: true
type: Species
is: P57103
has only substance units: false
name: SLC8A3
constant: false
is encoded by: hsa:6547
initial amount: NaN
is: SBO:0000252
initial concentration: NaN

metaR EX sphs1p LPAREN e RPAREN
kinetic law: MODEL1310110042#
reactant: MODEL1310110042#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Sphingosine 1-phosphate exchange
type: Reaction

metaR NDP7er
reactant: MODEL1310110042#
product: MODEL1310110042#
fast: false
name: nucleoside-diphosphatase (UDP), endoplasmic reticulum
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Nucleotide interconversion EC Number: 3.6.1.6 Confidence Level: 2 AUTHORS: PMID:10369669 NOTES:NCD
reversible: false
type: Reaction
kinetic law: MODEL1310110042#
is described by: ECO:0000000

metaM retinal 11 cis c
constant: false
notes: FORMULA: C20H28O CHARGE: 0 INCHI: InChI=1S/C20H28O/c1-16(8-6-9-17(2)13-15-21)11-12-19-18(3)10-7-14-20(19,4)5/h6,8-9,11-13,15H,7,10,14H2,1-5H3/b9-6-,12-11+,16-8+,17-13+
type: Species
boundary condition: false
has only substance units: false
is: HMDB02152
initial concentration: 1.0
name: 11-cis-retinal
is: CHEBI:16066
is: SBO:0000247
initial amount: NaN

metaR S6T9g
is described by: ECO:0000000
name: galactose/N-acetylglucosamine 6-O-sulfotransferase, Golgi apparatus
product: MODEL1310110042#
reactant: MODEL1310110042#
fast: false
type: Reaction
kinetic law: MODEL1310110042#
reversible: false
is: SBO:0000176
modifier: MODEL1310110042#
notes: GENE_ASSOCIATION: (23563.2) or (9435.1) or (23563.1) or (10164.1) or (4166.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: Confidence Level: 4 AUTHORS: PMID:10330415,PMID:10491328,PMID:10913333,PMID:11278593,PMID:12403612,PMID:12855678,PMID:9722682 NOTES:NCD

metaR EX glyb LPAREN e RPAREN
kinetic law: MODEL1310110042#
reactant: MODEL1310110042#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Glycine betaine exchange
type: Reaction

metaM glyclt x
has only substance units: false
constant: false
initial amount: NaN
is: CHEBI:29805
notes: FORMULA: C2H3O3 CHARGE: -1 INCHI: InChI=1S/C2H4O3/c3-1-2(4)5/h3H,1H2,(H,4,5)/p-1 EHMN_ABBREVIATION: C00160
name: glycolate
boundary condition: false
is: SBO:0000247
initial concentration: 1.0
type: Species
is: HMDB00115

metaR SEBCOACROT
kinetic law: MODEL1310110042#
product: MODEL1310110042#
reactant: MODEL1310110042#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: production of sebacoyl carnitine
type: Reaction

metaR GLCNACPT L
modifier: MODEL1310110042#
kinetic law: MODEL1310110042#
is: SBO:0000176
fast: false
is version of: http://identifiers.org/ec-code/2.7.8.15
product: MODEL1310110042#
reactant: MODEL1310110042#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (1798.1) or (1798.2) SUBSYSTEM: N-glycan synthesis EC Number: 2.7.8.15 Confidence Level: 0 AUTHORS: NOTES:NCD
reversible: false
type: Reaction
name: UDP-GlcNAc:dolichol-phosphate GlcNAc phosphotransferase (liver)

metaM L2aadp m
initial amount: NaN
notes: FORMULA: C6H10NO4 CHARGE: -1 INCHI: InChI=1S/C6H11NO4/c7-4(6(10)11)2-1-3-5(8)9/h4H,1-3,7H2,(H,8,9)(H,10,11)/p-1/t4-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00599 EHMN_ABBREVIATION: C00956
initial concentration: 1.0
boundary condition: false
is: HMDB00510
constant: false
type: Species
name: L-2-aminoadipate(1-)
is: CHEBI:58672
is: SBO:0000247
has only substance units: false

metaM strdnccoa c
has only substance units: false
is: C16163
is: SBO:0000247
initial amount: NaN
is: HMDB06519
initial concentration: 1.0
notes: FORMULA: C39H58N7O17P3S CHARGE: -4 INCHI: InChI=1/C39H62N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-30(48)67-23-22-41-29(47)20-21-42-37(51)34(50)39(2,3)25-60-66(57,58)63-65(55,56)59-24-28-33(62-64(52,53)54)32(49)38(61-28)46-27-45-31-35(40)43-26-44-36(31)46/h5-6,8-9,11-12,14-15,26-28,32-34,38,49-50H,4,7,10,13,16-25H2,1-3H3,(H,41,47)(H,42,51)(H,55,56)(H,57,58)(H2,40,43,44)(H2,52,53,54)/b6-5-,9-8-,12-11-,15-14-/t28-,32-,33?,34+,38-/m1/s1
type: Species
name: stearidonyl coenzyme A
is: http://identifiers.org/pubchem.compound/47205473
constant: false
boundary condition: false

metaR GALASE10ly
is: SBO:0000176
product: MODEL1310110042#
is version of: http://identifiers.org/ec-code/3.2.1.18
is described by: ECO:0000000
type: Reaction
is version of: http://identifiers.org/ec-code/3.1.6.4
kinetic law: MODEL1310110042#
is version of: http://identifiers.org/ec-code/3.2.1.23
reactant: MODEL1310110042#
reversible: false
modifier: MODEL1310110042#
is version of: http://identifiers.org/ec-code/3.4.16.5
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) or (5476.1) and (2720.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.23 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD
fast: false
name: beta-galactosidase, lysosomal

metaM hspg l
initial concentration: 1.0
is: SBO:0000247
is: CHEBI:17899
is: HMDB01993
notes: FORMULA: C79H113N5O101S12X CHARGE: -13
constant: false
has only substance units: false
name: heparan sulfate proteoglycan
initial amount: NaN
boundary condition: false
type: Species

metaM adpcoa c
initial concentration: 1.0
boundary condition: false
is: SBO:0000247
has only substance units: false
type: Species
initial amount: NaN
notes: FORMULA: C27H39N7O19P3S CHARGE: -5
is: C14143
is: HMDB04047
name: adipoylcoa
constant: false

metaR 2DR1PP
product: MODEL1310110042#
is: SBO:0000176
kinetic law: MODEL1310110042#
reactant: MODEL1310110042#
fast: false
reversible: false
name: 2-deoxy-D-ribose 1-phosphate phosphorylase
is described by: ECO:0000000
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Pyrimidine catabolism EC Number: 3.1.3.10 Confidence Level: 2 AUTHORS: PMID:9693094 NOTES:NCD

metaM dctp c
notes: FORMULA: C9H12N3O13P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00367 EHMN_ABBREVIATION: C00458
is: CHEBI:16311
name: dCTP
is: C00458
initial concentration: 1.0
initial amount: NaN
is: SBO:0000247
boundary condition: false
constant: false
has only substance units: false
is: HMDB00998
type: Species

http://identifiers.org/biomodels.db/MODEL1310110042#_7a041595_1ecc_45d1_934e_52a24318b2f9
initial concentration: NaN
initial amount: NaN
has only substance units: false
type: Species
boundary condition: true
name: NDUFB1
is: SBO:0000252
is: O75438
constant: false
is encoded by: hsa:4707

metaR RE2269E
is described by: ECO:0000000
fast: false
product: MODEL1310110042#
name: RE2269
is version of: http://identifiers.org/ec-code/3.4.21.39
kinetic law: MODEL1310110042#
reactant: MODEL1310110042#
notes: GENE_ASSOCIATION: (1215.1) SUBSYSTEM: Miscellaneous EC Number: 3.4.21.39 Confidence Level: 0 AUTHORS: PMID:1800960 NOTES:
reversible: true
modifier: MODEL1310110042#
type: Reaction
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110042#_63fe10e0_4958_4df7_88ba_76c0ee21cb7d
type: Species
constant: false
initial concentration: NaN
is: P54802
initial amount: NaN
is encoded by: hsa:4669
has only substance units: false
is: SBO:0000252
name: NAGLU
boundary condition: true

metaM 5hoxindact c
notes: FORMULA: C10H9NO2 CHARGE: 0 INCHI: InChI=1S/C10H9NO2/c12-4-3-7-6-11-10-2-1-8(13)5-9(7)10/h1-2,4-6,11,13H,3H2 HEPATONET_1.0_ABBREVIATION: HC01536 EHMN_ABBREVIATION: C05634
name: (5-hydroxyindol-3-yl)acetaldehyde
is: CHEBI:50157
boundary condition: false
has only substance units: false
initial amount: NaN
is: HMDB04073
type: Species
is: SBO:0000247
initial concentration: 1.0
constant: false

http://identifiers.org/biomodels.db/MODEL1310110042#_7cafc730_d5a7_425a_ae03_be964cc00dbc
boundary condition: true
initial concentration: NaN
type: Species
constant: false
has only substance units: false
initial amount: NaN
name: SI
is: P14410
is encoded by: hsa:6476
is: SBO:0000252

metaM acgal l
is: CHEBI:28037
name: N-acetyl-D-galactosamine
notes: FORMULA: C8H15NO6 CHARGE: 0 INCHI: InChI=1S/C8H15NO6/c1-3(11)9-5-7(13)6(12)4(2-10)15-8(5)14/h4-8,10,12-14H,2H2,1H3,(H,9,11)/t4-,5-,6+,7-,8?/m1/s1 EHMN_ABBREVIATION: C01132
has only substance units: false
is: SBO:0000247
is: HMDB00212
constant: false
type: Species
boundary condition: false
initial amount: NaN
initial concentration: 1.0

metaR EX malthp LPAREN e RPAREN
kinetic law: MODEL1310110042#
reactant: MODEL1310110042#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: maltoheptaose exchange
type: Reaction

metaR FAOXC260240x
modifier: MODEL1310110042#
is version of: http://identifiers.org/ec-code/2.3.1.16
is version of: http://identifiers.org/ec-code/1.1.1.35
is: SBO:0000176
reactant: MODEL1310110042#
notes: GENE_ASSOCIATION: (3295.1 and 30.1 and 51.2) or (51.1 and 30.1 and 1962.1) or (51.1 and 3295.1 and 30.1) or (30.1 and 51.2 and 1962.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.74 Confidence Level: 4 AUTHORS: NOTES:peroxisomal (very long chain FA) - in peroxisome, no fad, 1ste set of beta-ox is by acyl-coa oxidase (passes electrons directly to o2 -> h2o2) c26:0 -> c24:0 4 step FAO lumped also includes EC 1.1.1.35, 1.1.1.211, 1.3.3.6, 4.2.1.17, 4.2.1.74 -> into pmtcoa NJ
is version of: http://identifiers.org/ec-code/1.3.3.6
name: Beta oxidation of long chain fatty acid
fast: false
product: MODEL1310110042#
kinetic law: MODEL1310110042#
is described by: ECO:0000000
type: Reaction
is version of: http://identifiers.org/ec-code/4.2.1.107
reversible: false

metaR DHCR72r
product: MODEL1310110042#
is version of: http://identifiers.org/ec-code/1.3.1.21
kinetic law: MODEL1310110042#
reversible: false
notes: GENE_ASSOCIATION: (1717.1) SUBSYSTEM: Cholesterol metabolism EC Number: 1.3.1.21 Confidence Level: 4 AUTHORS: PMID:15670717 NOTES:lanosterol -> cholesterol pathway see paper refs Moebius et al PNAS 95:1899-1902 - check/re-check lit for more specific details (NADPH known to be cofactor - also NADH?, possibly rev?) NJ
modifier: MODEL1310110042#
fast: false
is described by: ECO:0000269
is: SBO:0000176
type: Reaction
name: 7-dehydrocholesterol reductase
reactant: MODEL1310110042#

http://identifiers.org/biomodels.db/MODEL1310110042#_c29b9f7f_3c6e_48ae_83df_f1511cd21e1e
is: SBO:0000252
name: PROSC
is encoded by: hsa:11212
boundary condition: true
initial amount: NaN
is: O94903
type: Species
constant: false
initial concentration: NaN
has only substance units: false

metaR r0881
type: Reaction
reactant: MODEL1310110042#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12107270,PMID:12739169,PMID:12829793,PMID:17245649,PMID:18375207,PMID:8476015,PMID:8557697,PMID:9786900 NOTES:
kinetic law: MODEL1310110042#
name: Active transport
is: SBO:0000185
fast: false
is described by: ECO:0000000
product: MODEL1310110042#
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110042#_6fae6962_742d_4135_9069_4c9b725df11c
initial amount: NaN
is: B3KTQ4
has only substance units: false
is: SBO:0000252
initial concentration: NaN
boundary condition: true
type: Species
name: B3GALNT1
is encoded by: hsa:8706
constant: false

http://identifiers.org/biomodels.db/MODEL1310110042#_4cbc2c1f_3c5c_437f_99d3_c158b9203e17
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:55907
initial concentration: NaN
is: Q8NFW8
type: Species
boundary condition: true
name: CMAS
constant: false
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110042#_2455359f_ed23_45af_b66d_695686de85c2
is encoded by: hsa:2650
boundary condition: true
is: SBO:0000252
name: GCNT1
is: Q02742
has only substance units: false
constant: false
initial amount: NaN
type: Species
initial concentration: NaN

metaM c226crn m
constant: false
initial amount: NaN
notes: FORMULA: C29H45NO4 CHARGE: 0 INCHI: InChI=1/C29H45NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-24-29(33)34-27(25-28(31)32)26-30(2,3)4/h6-7,9-10,12-13,15-16,18-19,21-22,27H,5,8,11,14,17,20,23-26H2,1-4H3/b7-6+,10-9+,13-12+,16-15+,19-18+,22-21+
is: http://identifiers.org/pubchem.compound/127055
initial concentration: 1.0
is: HMDB06510
boundary condition: false
name: cervonyl carnitine
type: Species
has only substance units: false
is: SBO:0000247

metaM ahcys c
type: Species
is: C00021
has only substance units: false
name: S-Adenosyl-L-homocysteine
initial amount: NaN
boundary condition: false
is: CHEBI:16680
initial concentration: 1.0
is: HMDB00939
is: SBO:0000247
notes: FORMULA: C14H20N6O5S CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00031 EHMN_ABBREVIATION: C00021
constant: false

metaM limnen e
is: HMDB03375
type: Species
initial amount: NaN
has only substance units: false
is: SBO:0000247
name: limonene
boundary condition: false
is: CHEBI:15384
notes: FORMULA: C10H16 CHARGE: 0 INCHI: InChI=1S/C10H16/c1-8(2)10-6-4-9(3)5-7-10/h4,10H,1,5-7H2,2-3H3
constant: false
initial concentration: 1.0

metaR NDPK1n
reversible: true
modifier: MODEL1310110042#
name: nucleoside-diphosphate kinase (ATP:GDP), nuclear
notes: GENE_ASSOCIATION: (4831.1 and 4830.1) or (4830.2 and 4831.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.6 Confidence Level: 4 AUTHORS: PMID:15242782 NOTES:Many nucleoside diphosphates (eight described) can act as acceptors. While many ribo- and deoxyribonucleoside triphosphates can act as donors, only ATP is chosen as a donor to minimize the number of total reactions.
fast: false
reactant: MODEL1310110042#
is described by: ECO:0000134
product: MODEL1310110042#
is: SBO:0000176
type: Reaction
is version of: http://identifiers.org/ec-code/2.7.4.6
kinetic law: MODEL1310110042#

metaM xol7aone m
notes: FORMULA: C27H44O2 CHARGE: 0 INCHI: InChI=1S/C27H44O2/c1-17(2)7-6-8-18(3)21-9-10-22-25-23(12-14-27(21,22)5)26(4)13-11-20(28)15-19(26)16-24(25)29/h15,17-18,21-25,29H,6-14,16H2,1-5H3/t18-,21-,22+,23+,24-,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01464 EHMN_ABBREVIATION: C05455
is: SBO:0000247
type: Species
boundary condition: false
constant: false
initial concentration: 1.0
initial amount: NaN
name: 7alpha-hydroxycholest-4-en-3-one
has only substance units: false
is: CHEBI:17899
is: HMDB01993

http://identifiers.org/biomodels.db/MODEL1310110042#_46a1c734_8296_4d37_99e2_d66bca1ba3f7
is: P13804
boundary condition: true
name: ETFA
is encoded by: hsa:2108
constant: false
initial concentration: NaN
initial amount: NaN
type: Species
has only substance units: false
is: SBO:0000252

metaM udpgal g
name: UDP-D-galactose(2-)
notes: FORMULA: C15H22N2O17P2 CHARGE: -2 INCHI: InChI=1S/C15H24N2O17P2/c18-3-5-8(20)10(22)12(24)14(32-5)33-36(28,29)34-35(26,27)30-4-6-9(21)11(23)13(31-6)17-2-1-7(19)16-15(17)25/h1-2,5-6,8-14,18,20-24H,3-4H2,(H,26,27)(H,28,29)(H,16,19,25)/p-2/t5-,6-,8+,9-,10+,11-,12-,13-,14?/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00057 EHMN_ABBREVIATION: C00052
initial concentration: 1.0
has only substance units: false
is: HMDB00302
type: Species
constant: false
is: CHEBI:58439
boundary condition: false
is: SBO:0000247
initial amount: NaN

metaM arachd r
notes: FORMULA: C20H31O2 CHARGE: -1 INCHI: InChI=1S/C20H32O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20(21)22/h6-7,9-10,12-13,15-16H,2-5,8,11,14,17-19H2,1H3,(H,21,22)/p-1/b7-6-,10-9-,13-12-,16-15- HEPATONET_1.0_ABBREVIATION: HC00202 EHMN_ABBREVIATION: C00219
boundary condition: false
initial concentration: 1.0
initial amount: NaN
name: arachidonate
is: HMDB01043
is: SBO:0000247
type: Species
constant: false
has only substance units: false
is: CHEBI:32395

metaM 3odcoa m
is: SBO:0000247
name: 3-Oxodecanoyl-CoA
has only substance units: false
notes: FORMULA: C31H48N7O18P3S CHARGE: -4 INCHI: InChI=1S/C31H52N7O18P3S/c1-4-5-6-7-8-9-19(39)14-22(41)60-13-12-33-21(40)10-11-34-29(44)26(43)31(2,3)16-53-59(50,51)56-58(48,49)52-15-20-25(55-57(45,46)47)24(42)30(54-20)38-18-37-23-27(32)35-17-36-28(23)38/h17-18,20,24-26,30,42-43H,4-16H2,1-3H3,(H,33,40)(H,34,44)(H,48,49)(H,50,51)(H2,32,35,36)(H2,45,46,47)/t20-,24-,25-,26+,30-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01404 EHMN_ABBREVIATION: C05265
is: HMDB03939
boundary condition: false
type: Species
constant: false
is: CHEBI:28528
initial amount: NaN
initial concentration: 1.0

metaR PHYCBOXL
is: SBO:0000176
fast: false
reactant: MODEL1310110042#
product: MODEL1310110042#
type: Reaction
is version of: http://identifiers.org/ec-code/4.1.1.28
is described by: ECO:0000212
name: L-Phenylalanine carboxy-lyase
reversible: false
notes: GENE_ASSOCIATION: (1644.1) SUBSYSTEM: Phenylalanine metabolism EC Number: 4.1.1.28 Confidence Level: 1 AUTHORS: NOTES:SAB
kinetic law: MODEL1310110042#
modifier: MODEL1310110042#

metaM HC02203 e
type: Species
boundary condition: false
is: SBO:0000247
initial amount: NaN
name: prostaglandin-a2
is: CHEBI:27820
constant: false
has only substance units: false
notes: FORMULA: C20H29O4 CHARGE: -1 INCHI: InChI=1S/C20H30O4/c1-2-3-6-9-17(21)14-12-16-13-15-19(22)18(16)10-7-4-5-8-11-20(23)24/h4,7,12-18,21H,2-3,5-6,8-11H2,1H3,(H,23,24)/b7-4-,14-12+/t16-,17-,18+/m0/s1 EHMN_ABBREVIATION: C05953
initial concentration: 1.0

metaR UMPKn
is version of: http://identifiers.org/ec-code/2.7.4.14
fast: false
reversible: true
type: Reaction
product: MODEL1310110042#
kinetic law: MODEL1310110042#
modifier: MODEL1310110042#
is: SBO:0000176
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:NCD
name: UMP kinase, nuclear
reactant: MODEL1310110042#

metaR S6T18g
is version of: http://identifiers.org/ec-code/2.8.2.21
is: SBO:0000176
fast: false
is described by: ECO:0000000
kinetic law: MODEL1310110042#
reversible: false
modifier: MODEL1310110042#
name: galactose/N-acetylglucosamine 6-O-sulfotransferase, Golgi apparatus
product: MODEL1310110042#
notes: GENE_ASSOCIATION: (8534.1) or (9469.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: Confidence Level: 4 AUTHORS: PMID:12403612,PMID:8991509,PMID:9405439,PMID:9714738 NOTES:NCD
reactant: MODEL1310110042#
type: Reaction
is version of: http://identifiers.org/ec-code/2.8.2.17

metaM 3decdicoa x
is: SBO:0000247
is: http://identifiers.org/pubchem.compound/16019966
type: Species
has only substance units: false
boundary condition: false
constant: false
initial concentration: 1.0
notes: FORMULA: C31H46N7O17P3S CHARGE: -4
name: 3,7-decadienoylcoa
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110042#_fd095170_faac_4360_a67a_04c6c6a3d406
is: E9KL44
name: HADHA
constant: false
initial concentration: NaN
boundary condition: true
has only substance units: false
is encoded by: hsa:3030
type: Species
is: SBO:0000252
initial amount: NaN

metaR FAOXC161C161OHm
kinetic law: MODEL1310110042#
product: MODEL1310110042#
reactant: MODEL1310110042#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: production of 3-hydroxyhexadecenoylcoA
type: Reaction

metaR MGSA
is: SBO:0000176
product: MODEL1310110042#
fast: false
reversible: false
name: methylglyoxal synthase
type: Reaction
kinetic law: MODEL1310110042#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Pyruvate metabolism EC Number: 4.2.3.3 Confidence Level: 4 AUTHORS: PMID:1537826,PMID:16037240,PMID:8853285 NOTES:Previously EC 4.2.99.11 this rxn represents the enzymatic conversion or non-enzymatic fragmentation of dhap to mthgxl - NCD
reactant: MODEL1310110042#

metaR r0360
name: Glycolysis / Glyconeogenesis EC:2.7.1.1
notes: GENE_ASSOCIATION: (65985.1) or (R39999.1) SUBSYSTEM: Fructose and mannose metabolism EC Number: 2.7.1.1 Confidence Level: 0 AUTHORS: PMID:16906315,PMID:7061426,PMID:7150652,PMID:8717435 NOTES:
is version of: http://identifiers.org/ec-code/6.2.1.16
product: MODEL1310110042#
kinetic law: MODEL1310110042#
modifier: MODEL1310110042#
is: SBO:0000176
reversible: false
is described by: ECO:0000000
type: Reaction
reactant: MODEL1310110042#
fast: false

metaR EX glyc LPAREN e RPAREN
kinetic law: MODEL1310110042#
reactant: MODEL1310110042#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Glycerol exchange
type: Reaction

metaM ala L c
boundary condition: false
is: HMDB00161
has only substance units: false
initial amount: NaN
is: CHEBI:16977
name: L-alanine
type: Species
initial concentration: 1.0
notes: FORMULA: C3H7NO2 CHARGE: 0 INCHI: InChI=1S/C3H7NO2/c1-2(4)3(5)6/h2H,4H2,1H3,(H,5,6)/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00048
constant: false
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110042#_c27eefba_7cce_4612_8d4b_6b6978281f9d
has only substance units: false
boundary condition: true
is encoded by: hsa:10057
constant: false
initial amount: NaN
type: Species
name: ABCC5
is: SBO:0000252
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110042#_ff13ffc2_2029_4fb3_b8df_5f2bdac46c99
initial amount: NaN
constant: false
is: SBO:0000252
is encoded by: hsa:C7orf24
boundary condition: true
name: _C7orf24_1_m
type: Species
initial concentration: NaN
has only substance units: false

metaR EX ascb L LPAREN e RPAREN
kinetic law: MODEL1310110042#
reactant: MODEL1310110042#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: L-Ascorbate exchange
type: Reaction

metaR r2060
reactant: MODEL1310110042#
modifier: MODEL1310110042#
reversible: false
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
type: Reaction
is described by: ECO:0000000
fast: false
product: MODEL1310110042#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.15
is: SBO:0000185
kinetic law: MODEL1310110042#

metaR GGH 10FTHF7GLUe
type: Reaction
is described by: ECO:0000000
reactant: MODEL1310110042#
product: MODEL1310110042#
name: Gamma-glutamyl hydrolase (10FTHF7GLU), extracellular
modifier: MODEL1310110042#
kinetic law: MODEL1310110042#
fast: false
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.4.19.9
notes: GENE_ASSOCIATION: (8836.1) SUBSYSTEM: Folate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:11375437,PMID:2867095,PMID:9614206 NOTES:REMOVES EITHER ONE OR TWO GLUTAMYL RESIDUES WITH A REACTION (WILL ONLY REPRESENT 1) IT
reversible: false

metaM hdd2coa c
name: trans-Hexadec-2-enoyl-CoA
is: C05272
is: SBO:0000247
notes: FORMULA: C37H60N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC01411 EHMN_ABBREVIATION: C05272
initial amount: NaN
has only substance units: false
boundary condition: false
initial concentration: 1.0
is: HMDB03945
is: CHEBI:61526
constant: false
type: Species

metaR 3HBCOARc
kinetic law: MODEL1310110042#
product: MODEL1310110042#
reactant: MODEL1310110042#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: transport of (R)-3-hydroxybutanoyl-CoA into cytosol
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110042#_b6e4ab46_fe14_4451_a5aa_a67b4b6714ab
type: Species
is: O43708
constant: false
initial amount: NaN
name: GSTZ1
is encoded by: hsa:2954
is: SBO:0000252
boundary condition: true
has only substance units: false
initial concentration: NaN

metaR LDH L
modifier: MODEL1310110042#
type: Reaction
is described by: ECO:0000000
kinetic law: MODEL1310110042#
fast: false
reactant: MODEL1310110042#
is: SBO:0000176
reversible: true
is version of: http://identifiers.org/ec-code/1.1.1.27
notes: GENE_ASSOCIATION: (3945.1 and 3939.1) or (160287.1) or (3948.2) or (3939.1) or (3948.1) or (55293.1) or (3945.1) or (92483.1) SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: 1.1.1.27 Confidence Level: 0 AUTHORS: PMID:11377399,PMID:15240094,PMID:2440048 NOTES:Also see LDL_D
name: L-lactate dehydrogenase
product: MODEL1310110042#

metaM ru5p D r
type: Species
initial concentration: 1.0
has only substance units: false
initial amount: NaN
is: HMDB00618
name: D-ribulose 5-phosphate(2-)
constant: false
is: CHEBI:58121
notes: FORMULA: C5H9O8P CHARGE: -2 INCHI: InChI=1S/C5H11O8P/c6-1-3(7)5(9)4(8)2-13-14(10,11)12/h4-6,8-9H,1-2H2,(H2,10,11,12)/p-2/t4-,5+/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00188
is: SBO:0000247
boundary condition: false

metaR EX 5thf LPAREN e RPAREN
kinetic law: MODEL1310110042#
reactant: MODEL1310110042#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: pentaglutamyl folate (THF) exchange
type: Reaction

metaM m2mpdol L c
type: Species
initial concentration: 1.0
constant: false
initial amount: NaN
is: SBO:0000247
has only substance units: false
notes: FORMULA: C1420H2328N20O320P20 CHARGE: -20
name: (alpha-D-mannosyl)2-beta-D-mannosyl-diacetylchitobiosyldiphosphodolichol, human liver homolog
boundary condition: false
is: CHEBI:28049

metaM prostge2 c
initial concentration: 1.0
constant: false
has only substance units: false
notes: FORMULA: C20H31O5 CHARGE: -1 INCHI: InChI=1S/C20H32O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h4,7,12-13,15-17,19,21,23H,2-3,5-6,8-11,14H2,1H3,(H,24,25)/p-1/b7-4-,13-12+/t15-,16+,17+,19+/m0/s1 EHMN_ABBREVIATION: C00584
is: CHEBI:606564
is: SBO:0000247
name: prostaglandin E2(1-)
initial amount: NaN
type: Species
is: HMDB01220
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110042#_5b2494f6_9dce_4f7b_bfff_1a9231ed800e
has only substance units: false
name: AMPD2
initial concentration: NaN
initial amount: NaN
type: Species
constant: false
is encoded by: hsa:271
is: Q01433
boundary condition: true
is: SBO:0000252

metaR ATPH2e
is version of: http://identifiers.org/ec-code/3.6.1.6
is version of: http://identifiers.org/ec-code/3.6.1.5
name: ATP diphosphohydrolase
product: MODEL1310110042#
type: Reaction
fast: false
modifier: MODEL1310110042#
kinetic law: MODEL1310110042#
is described by: ECO:0000269
is: SBO:0000176
reversible: false
reactant: MODEL1310110042#
notes: GENE_ASSOCIATION: (954.2) or (954.1) or (953.1) or (956.1) or (955.1) or (957.1) SUBSYSTEM: Nucleotide interconversion EC Number: 3.6.1.5 Confidence Level: 4 AUTHORS: PMID:8955160,PMID:9676430 NOTES:IT

metaR EX hexc LPAREN e RPAREN
kinetic law: MODEL1310110042#
reactant: MODEL1310110042#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: hexacosanoate (n-C26:0) exchange
type: Reaction

metaR C12OHc
kinetic law: MODEL1310110042#
product: MODEL1310110042#
reactant: MODEL1310110042#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: production of 3-OHdodecanoylcarnitinec
type: Reaction

metaR NDP8
is described by: ECO:0000269
fast: false
kinetic law: MODEL1310110042#
notes: GENE_ASSOCIATION: (1841.1) SUBSYSTEM: Nucleotide interconversion EC Number: 3.6.1.6 Confidence Level: 4 AUTHORS: NOTES:
is: SBO:0000176
name: nucleoside-diphosphatase (dUDP)
product: MODEL1310110042#
reactant: MODEL1310110042#
type: Reaction
is version of: http://identifiers.org/ec-code/2.7.4.9
modifier: MODEL1310110042#
reversible: false

metaR CYSTHRNaEx
reversible: false
modifier: MODEL1310110042#
notes: GENE_ASSOCIATION: (6509.1) or (6510.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14530974 NOTES:SAB see Kanai and Hediger 2004 (2003), PMID 14530974
kinetic law: MODEL1310110042#
is: SBO:0000185
fast: false
type: Reaction
product: MODEL1310110042#
is described by: ECO:0000269
reactant: MODEL1310110042#
name: L-cysteine/L-threonine Na-dependent exchange (Cys-L in)

metaR r2061
is: SBO:0000185
reactant: MODEL1310110042#
kinetic law: MODEL1310110042#
type: Reaction
product: MODEL1310110042#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.15
reversible: false
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
modifier: MODEL1310110042#
fast: false

metaM HC00718 c
has only substance units: false
type: Species
notes: FORMULA: C3H9NO4P CHARGE: -1 INCHI: InChI=1S/C3H10NO4P/c1-4-2-3-8-9(5,6)7/h4H,2-3H2,1H3,(H2,5,6,7)/p-1
initial concentration: 1.0
initial amount: NaN
name: N-methylethanolaminium phosphate(1-)
is: SBO:0000247
boundary condition: false
constant: false
is: CHEBI:57781

http://identifiers.org/biomodels.db/MODEL1310110042#_fb045157_3ae0_4450_8af3_440b4830e5f9
initial amount: NaN
constant: false
is: O00754
boundary condition: true
is encoded by: hsa:4125
name: MAN2B1
is: SBO:0000252
has only substance units: false
initial concentration: NaN
type: Species

metaM pep m
has only substance units: false
notes: FORMULA: C3H2O6P CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00076 EHMN_ABBREVIATION: C00074
boundary condition: false
initial concentration: 1.0
is: SBO:0000247
is: CHEBI:18021
name: Phosphoenolpyruvate
constant: false
is: HMDB00263
type: Species
is: C00074
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110042#_c0cf5aea_0353_4d26_8ddf_f37b5e82d86e
is: SBO:0000252
is encoded by: hsa:2882
boundary condition: true
initial amount: NaN
is: Q96SL4
has only substance units: false
type: Species
initial concentration: NaN
constant: false
name: GPX7

http://identifiers.org/biomodels.db/MODEL1310110042#_71848bb9_1b20_4439_872d_8bff0be5ac0e
type: Species
is encoded by: hsa:10797
boundary condition: true
is: SBO:0000252
has only substance units: false
name: MTHFD2
is: P13995
initial amount: NaN
initial concentration: NaN
constant: false

metaM ala L e
name: L-alanine
is: CHEBI:16977
initial amount: NaN
initial concentration: 1.0
constant: false
is: HMDB00161
has only substance units: false
boundary condition: false
type: Species
is: SBO:0000247
notes: FORMULA: C3H7NO2 CHARGE: 0 INCHI: InChI=1S/C3H7NO2/c1-2(4)3(5)6/h2H,4H2,1H3,(H,5,6)/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00048

metaR RE2625M
is: SBO:0000176
kinetic law: MODEL1310110042#
product: MODEL1310110042#
fast: false
is version of: http://identifiers.org/ec-code/1.14.13.15
modifier: MODEL1310110042#
reversible: true
name: RE2625
type: Reaction
reactant: MODEL1310110042#
notes: GENE_ASSOCIATION: (1593.1) SUBSYSTEM: Bile acid synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:9660774 NOTES:
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110042#_1bd6c01f_df74_48f7_b7bf_bd5d40821923
has only substance units: false
is encoded by: hsa:4513
initial amount: NaN
is: SBO:0000252
constant: false
initial concentration: NaN
boundary condition: true
name: COX2
type: Species
is: Q7GXZ8

metaM ksi deg2 l
name: keratan sulfate I, degradation product 2
has only substance units: false
boundary condition: false
initial concentration: 1.0
is: SBO:0000247
is: HMDB00573
type: Species
constant: false
initial amount: NaN
is: CHEBI:30825
notes: FORMULA: C241H384N17O210S12 CHARGE: -13

metaR 2OXOADOXm
is version of: http://identifiers.org/ec-code/2.3.1.61
is version of: http://identifiers.org/ec-code/1.8.1.4
fast: false
notes: GENE_ASSOCIATION: (4967.1) and (1738.1 and 8050.1) and (1743.1) or (4967.2) and (1738.1 and 8050.1) and (1743.1) SUBSYSTEM: Lysine metabolism EC Number: 2.3.1.61 Confidence Level: 2 AUTHORS: NOTES:SAB
kinetic law: MODEL1310110042#
reactant: MODEL1310110042#
is described by: ECO:0000304
type: Reaction
modifier: MODEL1310110042#
name: 2-Oxoadipate:lipoamde 2-oxidoreductase(decarboxylating and acceptor-succinylating) (mitochondria)
is version of: http://identifiers.org/ec-code/1.2.4.2
is: SBO:0000176
product: MODEL1310110042#
reversible: false

metaR ARACHDtr
product: MODEL1310110042#
name: intracellular transport
reactant: MODEL1310110042#
is described by: ECO:0000000
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: NOTES:unknown mechanism, presumed diffusion NJ
kinetic law: MODEL1310110042#
fast: false
type: Reaction
is: SBO:0000185

metaR AICART
product: MODEL1310110042#
kinetic law: MODEL1310110042#
notes: GENE_ASSOCIATION: (471.1) SUBSYSTEM: Purine synthesis EC Number: 2.1.2.3 Confidence Level: 4 AUTHORS: PMID:11948179,PMID:14966129,PMID:9378707 NOTES:
fast: false
reactant: MODEL1310110042#
is: SBO:0000176
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/2.1.2.3
modifier: MODEL1310110042#
name: phosphoribosylaminoimidazolecarboxamide formyltransferase
type: Reaction
reversible: true

metaR C9BRxtc
kinetic law: MODEL1310110042#
product: MODEL1310110042#
reactant: MODEL1310110042#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: transport of dimethylnonanoylcarnitine from peroxisomes to cytosol
type: Reaction

metaR r0990
product: MODEL1310110042#
kinetic law: MODEL1310110042#
is: SBO:0000185
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 0 AUTHORS: PMID:10884298,PMID:6469982 NOTES:
fast: false
name: Postulated transport reaction
reactant: MODEL1310110042#
reversible: true
type: Reaction

metaR LINKDEG2ly
fast: false
type: Reaction
product: MODEL1310110042#
is described by: ECO:0000000
name: degradation of proteoglycan linkage region, lysosomal
reactant: MODEL1310110042#
is: SBO:0000176
reversible: false
kinetic law: MODEL1310110042#
notes: GENE_ASSOCIATION: SUBSYSTEM: Chondroitin sulfate degradation EC Number: Confidence Level: 2 AUTHORS: PMID:8993162 NOTES:NCD

metaR LNLNCACPT1
modifier: MODEL1310110042#
reversible: false
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/2.3.1.21
product: MODEL1310110042#
is: SBO:0000176
fast: false
reactant: MODEL1310110042#
name: carnitine O-palmitoyltransferase
notes: GENE_ASSOCIATION: (1375.1) or (1375.3) or (1375.4) or (126129.1) or (1374.1) or (1375.2) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.21 Confidence Level: 4 AUTHORS: NOTES:NJ
kinetic law: MODEL1310110042#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110042#_metaR_EX_s2l2fn2m2masn_LPAREN_e_RPAREN_
kinetic law: MODEL1310110042#
reactant: MODEL1310110042#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: PA6 exchange
type: Reaction

metaM eitetcoa x
initial amount: NaN
is: http://identifiers.org/pubchem.compound/24892790
notes: FORMULA: C41H62N7O17P3S CHARGE: -4
has only substance units: false
boundary condition: false
constant: false
name: 5,8,11,14-eicosatetraenoylcoa
type: Species
initial concentration: 1.0
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110042#_c1ac5b17_a713_4c82_93b4_ae0a6a5bd2a1
is: Q9BXS1
is: SBO:0000252
initial concentration: NaN
constant: false
name: IDI2
has only substance units: false
type: Species
boundary condition: true
is encoded by: hsa:91734
initial amount: NaN

metaR FAOXC226m
kinetic law: MODEL1310110042#
product: MODEL1310110042#
reactant: MODEL1310110042#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: isomerization(C22:6)m
type: Reaction

metaR NACHEX24ly
modifier: MODEL1310110042#
type: Reaction
reversible: false
is: SBO:0000176
product: MODEL1310110042#
notes: GENE_ASSOCIATION: (3074.1) or (3073.1) or (3073.1 and 3074.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.52 Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12706724,PMID:8993162 NOTES:NCD
reactant: MODEL1310110042#
kinetic law: MODEL1310110042#
name: beta-N-acetylhexosaminidase, lysosomal
fast: false
is version of: http://identifiers.org/ec-code/3.2.1.52
is described by: ECO:0000000

metaM prostge2 e
constant: false
initial concentration: 1.0
is: CHEBI:606564
notes: FORMULA: C20H31O5 CHARGE: -1 INCHI: InChI=1S/C20H32O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h4,7,12-13,15-17,19,21,23H,2-3,5-6,8-11,14H2,1H3,(H,24,25)/p-1/b7-4-,13-12+/t15-,16+,17+,19+/m0/s1 EHMN_ABBREVIATION: C00584
is: SBO:0000247
has only substance units: false
initial amount: NaN
is: HMDB01220
type: Species
boundary condition: false
name: prostaglandin E2(1-)

http://identifiers.org/biomodels.db/MODEL1310110042#_aef08d87_bf31_48b3_9957_df01edd50791
is encoded by: hsa:125
constant: false
has only substance units: false
initial amount: NaN
is: P00325
type: Species
initial concentration: NaN
is: SBO:0000252
boundary condition: true
name: ADH1B

metaM chol m
initial amount: NaN
boundary condition: false
type: Species
initial concentration: 1.0
name: choline
has only substance units: false
is: CHEBI:15354
is: HMDB00097
notes: FORMULA: C5H14NO CHARGE: 1 INCHI: InChI=1S/C5H14NO/c1-6(2,3)4-5-7/h7H,4-5H2,1-3H3/q+1 HEPATONET_1.0_ABBREVIATION: HC00112 EHMN_ABBREVIATION: C00114
constant: false
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110042#_d7c7a949_590a_41ec_87f8_4dfab9bed8de
constant: false
type: Species
initial concentration: NaN
is: SBO:0000252
name: SLC33A1
is encoded by: hsa:9197
is: O00400
boundary condition: true
has only substance units: false
initial amount: NaN

metaM strdnccoa m
initial amount: NaN
name: stearidonyl coenzyme A
constant: false
is: HMDB06519
is: http://identifiers.org/pubchem.compound/47205473
is: SBO:0000247
type: Species
notes: FORMULA: C39H58N7O17P3S CHARGE: -4 INCHI: InChI=1/C39H62N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-30(48)67-23-22-41-29(47)20-21-42-37(51)34(50)39(2,3)25-60-66(57,58)63-65(55,56)59-24-28-33(62-64(52,53)54)32(49)38(61-28)46-27-45-31-35(40)43-26-44-36(31)46/h5-6,8-9,11-12,14-15,26-28,32-34,38,49-50H,4,7,10,13,16-25H2,1-3H3,(H,41,47)(H,42,51)(H,55,56)(H,57,58)(H2,40,43,44)(H2,52,53,54)/b6-5-,9-8-,12-11-,15-14-/t28-,32-,33?,34+,38-/m1/s1
initial concentration: 1.0
is: C16163
has only substance units: false
boundary condition: false

metaM oxa e
name: oxalate(2-)
initial concentration: 1.0
initial amount: NaN
notes: FORMULA: C2O4 CHARGE: -2 INCHI: InChI=1S/C2H2O4/c3-1(4)2(5)6/h(H,3,4)(H,5,6)/p-2 HEPATONET_1.0_ABBREVIATION: HC00195 EHMN_ABBREVIATION: C00209
boundary condition: false
constant: false
is: HMDB02329
has only substance units: false
is: CHEBI:30623
type: Species
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110042#_99157222_afcd_4298_b7eb_2d014b0efb17
is: SBO:0000252
name: MAT2A
has only substance units: false
initial amount: NaN
boundary condition: true
type: Species
initial concentration: NaN
is: P31153
is encoded by: hsa:4144
constant: false

metaR r0426
modifier: MODEL1310110042#
product: MODEL1310110042#
kinetic law: MODEL1310110042#
reversible: true
notes: GENE_ASSOCIATION: (5860.1) SUBSYSTEM: Unassigned EC Number: 4.2.1.3 Confidence Level: 0 AUTHORS: PMID:15263083,PMID:16511074 NOTES:
is: SBO:0000176
fast: false
is version of: http://identifiers.org/ec-code/1.5.1.34
type: Reaction
name: isocitrate hydro-lyase Citrate cycle (TCA cycle) / Glyoxylate and dicarboxylate metabolism EC:4.2.1.3
is described by: ECO:0000000
reactant: MODEL1310110042#

metaR r0365
name: 3-hydroxypropanoate:NAD+ oxidoreductase beta-Alanine metabolism / Propanoate metabolism EC:1.1.1.59
is: SBO:0000176
product: MODEL1310110042#
type: Reaction
modifier: MODEL1310110042#
is described by: ECO:0000000
reactant: MODEL1310110042#
reversible: false
kinetic law: MODEL1310110042#
notes: GENE_ASSOCIATION: (1718.1) SUBSYSTEM: Propanoate metabolism EC Number: 1.1.1.59 Confidence Level: 0 AUTHORS: PMID:13672942 NOTES:
is version of: http://identifiers.org/ec-code/1.3.1.72
fast: false

http://identifiers.org/biomodels.db/MODEL1310110042#_9df96202_5dcd_4c35_9b1c_053c270a2d69
boundary condition: true
has only substance units: false
is encoded by: hsa:443
constant: false
type: Species
is: SBO:0000252
initial amount: NaN
initial concentration: NaN
is: Q6FH48
name: ASPA

http://identifiers.org/biomodels.db/MODEL1310110042#_244554f6_5260_4ad5_a3d1_f48716b3c197
is: SBO:0000252
is encoded by: hsa:3155
name: HMGCL
is: Q6IBC0
initial amount: NaN
boundary condition: true
type: Species
constant: false
has only substance units: false
initial concentration: NaN

metaR LNLNCACPT2
is version of: http://identifiers.org/ec-code/2.3.1.21
fast: false
product: MODEL1310110042#
notes: GENE_ASSOCIATION: (1376.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: NOTES:NJ
type: Reaction
reactant: MODEL1310110042#
modifier: MODEL1310110042#
kinetic law: MODEL1310110042#
is: SBO:0000176
reversible: false
is described by: ECO:0000000
name: carnitine transferase

http://identifiers.org/biomodels.db/MODEL1310110042#_ddfa52ac_8e9c_4058_9e28_f81d11390f55
type: Species
initial concentration: NaN
is encoded by: hsa:5296
constant: false
is: SBO:0000297
has part: P42336
has only substance units: false
is encoded by: hsa:5290
initial amount: NaN
name: PIK3CA:PIK3R2
boundary condition: true
has part: O00459

http://identifiers.org/biomodels.db/MODEL1310110042#_b399eb6b_930a_4683_9ee4_498d44151798
is: Q9NRX3
initial amount: NaN
is: SBO:0000252
has only substance units: false
name: NDUFA4L2
constant: false
initial concentration: NaN
is encoded by: hsa:56901
boundary condition: true
type: Species

metaM ksii core2 pre3 g
type: Species
constant: false
is: C00130
has only substance units: false
is: CHEBI:58053
notes: FORMULA: C47H76N4O33X CHARGE: -1
is: SBO:0000247
initial concentration: 1.0
name: keratan sulfate II biosynthesis, precursor 3
boundary condition: false
initial amount: NaN
is: HMDB00175

http://identifiers.org/biomodels.db/MODEL1310110042#_6a86002f_e10a_470d_b70d_db5c23273ab3
is: SBO:0000297
is encoded by: hsa:4967
type: Species
name: DLD:DLST:OGDH:PDHX
has only substance units: false
constant: false
boundary condition: true
has part: B4E3E9
initial amount: NaN
initial concentration: NaN

metaM xol7aone c
is: SBO:0000247
notes: FORMULA: C27H44O2 CHARGE: 0 INCHI: InChI=1S/C27H44O2/c1-17(2)7-6-8-18(3)21-9-10-22-25-23(12-14-27(21,22)5)26(4)13-11-20(28)15-19(26)16-24(25)29/h15,17-18,21-25,29H,6-14,16H2,1-5H3/t18-,21-,22+,23+,24-,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01464 EHMN_ABBREVIATION: C05455
is: CHEBI:17899
name: 7alpha-hydroxycholest-4-en-3-one
type: Species
initial concentration: 1.0
constant: false
has only substance units: false
is: HMDB01993
boundary condition: false
initial amount: NaN

metaM 6pgc r
initial amount: NaN
is: SBO:0000247
is: HMDB01316
boundary condition: false
type: Species
notes: FORMULA: C6H10O10P CHARGE: -3 INCHI: InChI=1S/C6H13O10P/c7-2(1-16-17(13,14)15)3(8)4(9)5(10)6(11)12/h2-5,7-10H,1H2,(H,11,12)(H2,13,14,15)/p-3/t2-,3-,4+,5-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00292 EHMN_ABBREVIATION: C00345
constant: false
name: 6-phosphonatooxy-D-gluconate
has only substance units: false
initial concentration: 1.0
is: CHEBI:58759

metaM dopa e
is: HMDB00073
has only substance units: false
constant: false
is: CHEBI:59905
is: SBO:0000247
name: dopaminium(1+)
boundary condition: false
initial concentration: 1.0
notes: FORMULA: C8H12NO2 CHARGE: 1 INCHI: InChI=1S/C8H11NO2/c9-4-3-6-1-2-7(10)8(11)5-6/h1-2,5,10-11H,3-4,9H2/p+1 HEPATONET_1.0_ABBREVIATION: HC01175 EHMN_ABBREVIATION: C03758
initial amount: NaN
type: Species

http://identifiers.org/biomodels.db/MODEL1310110042#_10b45a95_9aba_48c3_a088_9dc08e1cbd0a
initial concentration: NaN
type: Species
is: B2RDU6
has only substance units: false
constant: false
is: SBO:0000252
is encoded by: hsa:4598
boundary condition: true
name: MVK
initial amount: NaN

metaR GPIMTer U
is described by: ECO:0000000
kinetic law: MODEL1310110042#
type: Reaction
reactant: MODEL1310110042#
modifier: MODEL1310110042#
name: GlcN-acylPI mannosyltransferase, endoplasmic reticulum
reversible: false
fast: false
notes: GENE_ASSOCIATION: (93183.1) and (54965.1) SUBSYSTEM: Phosphatidylinositol phosphate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:11226175,PMID:15635094 NOTES:NCD
product: MODEL1310110042#
is: SBO:0000176

metaR RE2659R
notes: GENE_ASSOCIATION: SUBSYSTEM: Vitamin A metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:9647871 NOTES:
fast: false
kinetic law: MODEL1310110042#
reversible: true
reactant: MODEL1310110042#
is described by: ECO:0000000
name: RE2659
product: MODEL1310110042#
type: Reaction
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110042#_5a7bb9d2_5b97_4836_8451_3f3e83219f0f
name: SGSH
constant: false
is: P51688
is encoded by: hsa:6448
boundary condition: true
is: SBO:0000252
initial amount: NaN
initial concentration: NaN
has only substance units: false
type: Species

metaM cysam c
is: SBO:0000247
is: HMDB02991
initial amount: NaN
name: cysteaminium
constant: false
initial concentration: 1.0
notes: FORMULA: C2H8NS CHARGE: 1 INCHI: InChI=1S/C2H7NS/c3-1-2-4/h4H,1-3H2/p+1 HEPATONET_1.0_ABBREVIATION: HC00823 EHMN_ABBREVIATION: C01678
has only substance units: false
boundary condition: false
type: Species
is: CHEBI:58029

metaR NACHEX1ly
kinetic law: MODEL1310110042#
reversible: false
name: beta-N-acetylhexosaminidase, lysosomal
type: Reaction
is described by: ECO:0000000
is: SBO:0000176
fast: false
product: MODEL1310110042#
is version of: http://identifiers.org/ec-code/3.2.1.52
reactant: MODEL1310110042#
notes: GENE_ASSOCIATION: (3073.1 and 3074.1) or (3073.1) or (3074.1) SUBSYSTEM: Chondroitin sulfate degradation EC Number: 3.2.1.52 Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12706724,PMID:8993162 NOTES:NCD
modifier: MODEL1310110042#

metaM dcsptn1crn c
notes: FORMULA: C29H47NO4 CHARGE: 0 INCHI: InChI=1/C29H47NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-24-29(33)34-27(25-28(31)32)26-30(2,3)4/h9-10,12-13,15-16,18-19,21-22,27H,5-8,11,14,17,20,23-26H2,1-4H3/b10-9+,13-12+,16-15+,19-18+,22-21+
initial amount: NaN
boundary condition: false
is: HMDB06321
initial concentration: 1.0
has only substance units: false
name: docosa-4,7,10,13,16-pentaenoyl carnitine
is: SBO:0000247
type: Species
constant: false

http://identifiers.org/biomodels.db/MODEL1310110042#_f2d9ed20_db2a_4612_9f2a_3f7aeaf14346
initial amount: NaN
type: Species
has only substance units: false
initial concentration: NaN
constant: false
boundary condition: true
is encoded by: hsa:55811
is: F5GWS5
is: SBO:0000252
name: ADCY10

http://identifiers.org/biomodels.db/MODEL1310110042#_957dbbd5_f021_404f_b7b3_2fbb57d449e6
boundary condition: true
initial amount: NaN
name: CYP1A1
is: A0N0X8
type: Species
has only substance units: false
is: SBO:0000252
initial concentration: NaN
constant: false
is encoded by: hsa:1543

metaR KHK
product: MODEL1310110042#
modifier: MODEL1310110042#
name: ketohexokinase
is: SBO:0000176
reversible: false
kinetic law: MODEL1310110042#
is version of: http://identifiers.org/ec-code/2.7.1.3
type: Reaction
reactant: MODEL1310110042#
notes: GENE_ASSOCIATION: (3795.1) or (3795.2) SUBSYSTEM: Fructose and mannose metabolism EC Number: 2.7.1.3 Confidence Level: 0 AUTHORS: NOTES:NCD
fast: false
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110042#_651c1015_3ce4_40ce_9098_8a1912a9cefa
initial concentration: NaN
name: SUOX
has only substance units: false
constant: false
type: Species
is encoded by: hsa:6821
is: P51687
initial amount: NaN
boundary condition: true
is: SBO:0000252

metaR DM Asn X Ser Thr ly
kinetic law: MODEL1310110042#
reactant: MODEL1310110042#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 0 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: false
name: DM Asn-X-Ser/Thr(ly)
type: Reaction

metaM HC10852 r
notes: FORMULA: C37H60N7O17P3S CHARGE: -4 INCHI: InChI=1S/C37H64N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-28(46)65-21-20-39-27(45)18-19-40-35(49)32(48)37(2,3)23-58-64(55,56)61-63(53,54)57-22-26-31(60-62(50,51)52)30(47)36(59-26)44-25-43-29-33(38)41-24-42-34(29)44/h9-10,24-26,30-32,36,47-48H,4-8,11-23H2,1-3H3,(H,39,45)(H,40,49)(H,53,54)(H,55,56)(H2,38,41,42)(H2,50,51,52)/p-4/b10-9-/t26-,30-,31-,32+,36-/m1/s1 EHMN_ABBREVIATION: CE0852
is: CHEBI:61540
initial amount: NaN
boundary condition: false
is: SBO:0000247
name: palmitoleyl-CoA(4-)
constant: false
type: Species
initial concentration: 1.0
has only substance units: false

metaM HC02203 c
name: prostaglandin-a2
is: SBO:0000247
type: Species
initial amount: NaN
has only substance units: false
notes: FORMULA: C20H29O4 CHARGE: -1 INCHI: InChI=1S/C20H30O4/c1-2-3-6-9-17(21)14-12-16-13-15-19(22)18(16)10-7-4-5-8-11-20(23)24/h4,7,12-18,21H,2-3,5-6,8-11H2,1H3,(H,23,24)/b7-4-,14-12+/t16-,17-,18+/m0/s1 EHMN_ABBREVIATION: C05953
initial concentration: 1.0
constant: false
is: CHEBI:27820
boundary condition: false

metaM retn c
initial amount: NaN
boundary condition: false
notes: FORMULA: C20H27O2 CHARGE: -1 INCHI: InChI=1S/C20H28O2/c1-15(8-6-9-16(2)14-19(21)22)11-12-18-17(3)10-7-13-20(18,4)5/h6,8-9,11-12,14H,7,10,13H2,1-5H3,(H,21,22)/p-1/b9-6+,12-11+,15-8+,16-14+ HEPATONET_1.0_ABBREVIATION: HC00532 EHMN_ABBREVIATION: C00777
is: CHEBI:35291
has only substance units: false
constant: false
is: SBO:0000247
type: Species
initial concentration: 1.0
is: HMDB01852
name: all-trans-retinoate

metaM arachd l
initial concentration: 1.0
is: SBO:0000247
initial amount: NaN
is: CHEBI:32395
name: arachidonate
type: Species
constant: false
has only substance units: false
notes: FORMULA: C20H31O2 CHARGE: -1 INCHI: InChI=1S/C20H32O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20(21)22/h6-7,9-10,12-13,15-16H,2-5,8,11,14,17-19H2,1H3,(H,21,22)/p-1/b7-6-,10-9-,13-12-,16-15- HEPATONET_1.0_ABBREVIATION: HC00202 EHMN_ABBREVIATION: C00219
boundary condition: false
is: HMDB01043

metaR C181CRNt
type: Reaction
notes: GENE_ASSOCIATION: (788.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: PMID:14598172 NOTES:TDV
is: SBO:0000185
kinetic law: MODEL1310110042#
product: MODEL1310110042#
fast: false
reactant: MODEL1310110042#
reversible: false
is described by: ECO:0000000
name: C181 transport into the mitochondria
modifier: MODEL1310110042#

metaR ALAASNNaEx
product: MODEL1310110042#
reversible: false
type: Reaction
is: SBO:0000185
is described by: ECO:0000269
reactant: MODEL1310110042#
modifier: MODEL1310110042#
notes: GENE_ASSOCIATION: (6510.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14530974 NOTES:SAB see Kanai and Hediger 2004 (2003), PMID 14530974
fast: false
name: L-alanine/L-asparagine Na-dependent exchange (Ala-L in)
kinetic law: MODEL1310110042#

metaM elaidcrn m
is: HMDB06464
constant: false
notes: FORMULA: C25H47NO4 CHARGE: 0 INCHI: InChI=1/C25H47NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-25(29)30-23(21-24(27)28)22-26(2,3)4/h12-13,23H,5-11,14-22H2,1-4H3/b13-12+
has only substance units: false
boundary condition: false
name: Elaidic carnitine
initial amount: NaN
is: SBO:0000247
type: Species
initial concentration: 1.0

metaR r0424
product: MODEL1310110042#
is version of: http://identifiers.org/ec-code/1.17.1.4
reversible: true
is described by: ECO:0000000
reactant: MODEL1310110042#
name: Isocitrate:NADP+ oxidoreductase (decarboxylating) Citrate cycle (TCA cycle) EC:1.1.1.42
fast: false
is: SBO:0000176
notes: GENE_ASSOCIATION: (7498.1) SUBSYSTEM: Unassigned EC Number: 1.1.1.42 Confidence Level: 0 AUTHORS: PMID:10521434,PMID:16489927,PMID:9866202 NOTES:
type: Reaction
modifier: MODEL1310110042#
kinetic law: MODEL1310110042#

metaM oxa c
name: oxalate(2-)
is: SBO:0000247
initial concentration: 1.0
notes: FORMULA: C2O4 CHARGE: -2 INCHI: InChI=1S/C2H2O4/c3-1(4)2(5)6/h(H,3,4)(H,5,6)/p-2 HEPATONET_1.0_ABBREVIATION: HC00195 EHMN_ABBREVIATION: C00209
boundary condition: false
initial amount: NaN
has only substance units: false
constant: false
is: HMDB02329
is: CHEBI:30623
type: Species

http://identifiers.org/biomodels.db/MODEL1310110042#_3cd11573_dca8_48de_a439_65726531a2d8
is: GO:0005739
is: SBO:0000290
constant: false
size: 1.0
spatial dimensions: 3.0
name: mitochondrion
type: Compartment

http://identifiers.org/biomodels.db/MODEL1310110042#_f6521605_a7d5_4cca_8053_40f3cc206142
initial concentration: NaN
boundary condition: true
name: UROC1
initial amount: NaN
is: SBO:0000252
constant: false
is: Q68CJ7
is encoded by: hsa:131669
type: Species
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110042#_d36d321d_2397_47dc_8179_72754cb6d1f8
type: Species
name: FUT8
constant: false
has only substance units: false
boundary condition: true
is: Q546E0
initial amount: NaN
is encoded by: hsa:2530
initial concentration: NaN
is: SBO:0000252

metaR EX perillyl LPAREN e RPAREN
kinetic law: MODEL1310110042#
reactant: MODEL1310110042#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Perillyl alcohol exchange
type: Reaction

metaM hexde7coa x
initial concentration: 1.0
name: 7-hexadecenoylcoa
type: Species
is: SBO:0000247
constant: false
has only substance units: false
notes: FORMULA: C37H60N7O17P3S CHARGE: -4
initial amount: NaN
boundary condition: false
is: HMDB02288

metaR CRNt
notes: GENE_ASSOCIATION: (6584.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12827517,PMID:12883891,PMID:9933568 NOTES:NCD
name: L-carnitine reversible transport
is described by: ECO:0000269
reversible: true
reactant: MODEL1310110042#
type: Reaction
fast: false
modifier: MODEL1310110042#
product: MODEL1310110042#
is: SBO:0000185
kinetic law: MODEL1310110042#

metaM acrn c
type: Species
name: O-acetylcarnitine
constant: false
is: CHEBI:57589
initial amount: NaN
boundary condition: false
is: HMDB00201
is: SBO:0000247
notes: FORMULA: C9H17NO4 CHARGE: 0 INCHI: InChI=1S/C9H17NO4/c1-7(11)14-8(5-9(12)13)6-10(2,3)4/h8H,5-6H2,1-4H3/t8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00966 EHMN_ABBREVIATION: C02571
initial concentration: 1.0
has only substance units: false

metaM CE2422 m
boundary condition: false
constant: false
name: 3-oxo-cis,cis-7,10-hexadecadienoyl-CoA
initial concentration: 1.0
is: CHEBI:28387
type: Species
is: SBO:0000247
initial amount: NaN
notes: FORMULA: C37H56N7O18P3S CHARGE: -4 INCHI: InChI=1/C37H60N7O18P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-25(45)20-28(47)66-19-18-39-27(46)16-17-40-35(50)32(49)37(2,3)22-59-65(56,57)62-64(54,55)58-21-26-31(61-63(51,52)53)30(48)36(60-26)44-24-43-29-33(38)41-23-42-34(29)44/h8-9,11-12,23-24,26,30-32,36,48-49H,4-7,10,13-22H2,1-3H3,(H,39,46)(H,40,50)(H,54,55)(H,56,57)(H2,38,41,42)(H2,51,52,53)/p-4/b9-8-,12-11-/t26-,30+,31+,32u,36-/m0/s1 EHMN_ABBREVIATION: CE2422
has only substance units: false
is: HMDB11123

http://identifiers.org/biomodels.db/MODEL1310110042#_c2c7ea96_c590_428d_95c7_536b2acab1c3
initial amount: NaN
has only substance units: false
is encoded by: hsa:AA177072
initial concentration: NaN
constant: false
is: SBO:0000252
type: Species
name: _AA177072_1_c
boundary condition: true

metaR N2M2NMASNtly
reactant: MODEL1310110042#
reversible: false
kinetic law: MODEL1310110042#
fast: false
product: MODEL1310110042#
name: n2m2nmasn transport, extracellular to lysosome
type: Reaction
is described by: ECO:0000000
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD

metaM hspg e
is: SBO:0000247
is: HMDB02259
name: heparan sulfate proteoglycan
is: CHEBI:32366
has only substance units: false
notes: FORMULA: C79H113N5O101S12X CHARGE: -13
type: Species
boundary condition: false
constant: false
initial amount: NaN
initial concentration: 1.0

metaM dopa c
is: SBO:0000247
initial amount: NaN
is: HMDB00073
is: CHEBI:59905
type: Species
initial concentration: 1.0
has only substance units: false
notes: FORMULA: C8H12NO2 CHARGE: 1 INCHI: InChI=1S/C8H11NO2/c9-4-3-6-1-2-7(10)8(11)5-6/h1-2,5,10-11H,3-4,9H2/p+1 HEPATONET_1.0_ABBREVIATION: HC01175 EHMN_ABBREVIATION: C03758
name: dopaminium(1+)
constant: false
boundary condition: false

metaR r0423
fast: false
type: Reaction
modifier: MODEL1310110042#
is version of: http://identifiers.org/ec-code/1.2.1.3
reversible: true
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (AA081045.1) or (AI620219.1) or (219.1) or (217.1) or (224.1) or (501.1) or (223.1) or (AU149534.1) or (T83654.1) SUBSYSTEM: Unassigned EC Number: 1.1.1.42 Confidence Level: 0 AUTHORS: PMID:10521434,PMID:16489927,PMID:9866202 NOTES:
name: Isocitrate:NADP+ oxidoreductase (decarboxylating) Citrate cycle (TCA cycle) EC:1.1.1.42
kinetic law: MODEL1310110042#
is: SBO:0000176
product: MODEL1310110042#
reactant: MODEL1310110042#

http://identifiers.org/biomodels.db/MODEL1310110042#_54d7fd63_0829_4352_8da8_b712d03d3261
has only substance units: false
boundary condition: true
type: Species
is: SBO:0000252
name: PFKL
initial amount: NaN
initial concentration: NaN
is: Q7L2M7
constant: false
is encoded by: hsa:5211

metaR G14T11g
name: beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase, Golgi
is version of: http://identifiers.org/ec-code/2.4.1.90
is described by: ECO:0000000
reversible: false
is version of: http://identifiers.org/ec-code/2.4.1.22
kinetic law: MODEL1310110042#
product: MODEL1310110042#
reactant: MODEL1310110042#
fast: false
notes: GENE_ASSOCIATION: (8703.1) or (8704.2) or (8704.1) or (2683.1) or (9334.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.38 Confidence Level: 4 AUTHORS: PMID:12512857,PMID:1903938,PMID:3094506,PMID:3144273,PMID:9405390,PMID:9435216 NOTES:Keratan sulfate I biosynthesis NCD
is: SBO:0000176
type: Reaction
modifier: MODEL1310110042#
is version of: http://identifiers.org/ec-code/2.4.1.38

metaR MALTt1r
fast: false
notes: GENE_ASSOCIATION: (6515.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10421229,PMID:12750891,PMID:3170580,PMID:8504756,PMID:9230074 NOTES:NCD
modifier: MODEL1310110042#
reversible: true
type: Reaction
is: SBO:0000185
is described by: ECO:0000269
reactant: MODEL1310110042#
name: maltose transport (uniport)
product: MODEL1310110042#
kinetic law: MODEL1310110042#

metaR S6TASE26ly
is described by: ECO:0000000
product: MODEL1310110042#
modifier: MODEL1310110042#
fast: false
reversible: true
notes: GENE_ASSOCIATION: (2799.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.1.6.14 Confidence Level: 4 AUTHORS: PMID:3196333,PMID:3689314,PMID:3689315 NOTES:NCD
kinetic law: MODEL1310110042#
is: SBO:0000176
reactant: MODEL1310110042#
type: Reaction
name: N-acetylglucosamine-6-sulfatase, lysosomal
is version of: http://identifiers.org/ec-code/3.1.6.14

http://identifiers.org/biomodels.db/MODEL1310110042#_24b4aaaa_34c2_4ba2_b0e4_2256cdaf2119
boundary condition: true
is: SBO:0000252
constant: false
is encoded by: hsa:60386
is: Q9HC21
initial concentration: NaN
name: SLC25A19
initial amount: NaN
type: Species
has only substance units: false

metaR UMPK
is described by: ECO:0000269
reactant: MODEL1310110042#
is: SBO:0000176
reversible: true
type: Reaction
name: UMP kinase
product: MODEL1310110042#
modifier: MODEL1310110042#
kinetic law: MODEL1310110042#
fast: false
is version of: http://identifiers.org/ec-code/2.7.4.14
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: NOTES:

metaR F6Tg
is: SBO:0000176
product: MODEL1310110042#
reversible: false
type: Reaction
fast: false
name: glycoprotein 6-alpha-L-fucosyltransferase
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (2530.4) or (2530.1) or (2530.3) or (2530.2) or (2530.5) SUBSYSTEM: N-glycan synthesis EC Number: 2.4.1.68 Confidence Level: 0 AUTHORS: PMID:14514715 NOTES:NCD
reactant: MODEL1310110042#
modifier: MODEL1310110042#
is version of: http://identifiers.org/ec-code/2.4.1.68
kinetic law: MODEL1310110042#

metaR RE1525M
kinetic law: MODEL1310110042#
notes: GENE_ASSOCIATION: (3295.1) or (1962.1) or (3033.1) or (3028.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.1.1.35 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:7775433 NOTES:
is version of: http://identifiers.org/ec-code/4.2.1.107
product: MODEL1310110042#
name: RE1525
type: Reaction
modifier: MODEL1310110042#
fast: false
is version of: http://identifiers.org/ec-code/1.1.1.35
is described by: ECO:0000000
reversible: true
is: SBO:0000176
reactant: MODEL1310110042#

metaM hdca r
initial amount: NaN
is: CHEBI:7896
type: Species
initial concentration: 1.0
has only substance units: false
is: HMDB00220
is: SBO:0000247
constant: false
notes: FORMULA: C16H31O2 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00226 EHMN_ABBREVIATION: C00249
is: C00249
boundary condition: false
name: Hexadecanoate (n-C16:0)

metaM r5p c
constant: false
is: CHEBI:18189
type: Species
notes: FORMULA: C5H9O8P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00115 EHMN_ABBREVIATION: C00117
boundary condition: false
initial amount: NaN
initial concentration: 1.0
is: HMDB00618
has only substance units: false
is: C00117
name: alpha-D-Ribose 5-phosphate
is: SBO:0000247

metaM dctp n
is: HMDB00998
is: C00458
name: dCTP
notes: FORMULA: C9H12N3O13P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00367 EHMN_ABBREVIATION: C00458
constant: false
type: Species
has only substance units: false
initial concentration: 1.0
is: CHEBI:16311
initial amount: NaN
is: SBO:0000247
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110042#_51eff93d_d089_46cb_a61f_6f82514cab37
is: Q5JZF5
initial concentration: NaN
type: Species
name: ALAS2
is encoded by: hsa:212
is: SBO:0000252
boundary condition: true
has only substance units: false
constant: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110042#_9937cb47_b7f4_4e48_baba_62f9b767a03e
type: Species
is: SBO:0000252
initial amount: NaN
is: O95139
boundary condition: true
constant: false
has only substance units: false
initial concentration: NaN
name: NDUFB6
is encoded by: hsa:4712

metaM pep c
is: C00074
type: Species
has only substance units: false
initial amount: NaN
is: HMDB00263
is: SBO:0000247
name: Phosphoenolpyruvate
boundary condition: false
is: CHEBI:18021
constant: false
initial concentration: 1.0
notes: FORMULA: C3H2O6P CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00076 EHMN_ABBREVIATION: C00074

metaR r0879
fast: false
is: SBO:0000185
is described by: ECO:0000000
product: MODEL1310110042#
name: TCDB:2.A.29.2.4 TCDB:2.A.29.16.1
type: Reaction
reversible: false
reactant: MODEL1310110042#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11287335,PMID:11327718 NOTES:
kinetic law: MODEL1310110042#

http://identifiers.org/biomodels.db/MODEL1310110042#_e76234df_aefe_4420_86d2_38e39271ed75
initial concentration: NaN
type: Species
is: SBO:0000252
is: O00330
name: PDHX
initial amount: NaN
is encoded by: hsa:8050
has only substance units: false
boundary condition: true
constant: false

metaR ALR2
modifier: MODEL1310110042#
is: SBO:0000176
product: MODEL1310110042#
notes: GENE_ASSOCIATION: (10327.2) or (8574.1) or (10327.1) or (231.1) SUBSYSTEM: Pyruvate metabolism EC Number: 1.1.1.21 Confidence Level: 4 AUTHORS: PMID:12071861,PMID:1537826,PMID:9823300 NOTES:NCD
name: aldose reductase (methylglyoxal)
is version of: http://identifiers.org/ec-code/1.1.1.21
reversible: false
is described by: ECO:0000269
kinetic law: MODEL1310110042#
fast: false
reactant: MODEL1310110042#
type: Reaction
is version of: http://identifiers.org/ec-code/1.1.1.2

metaM HC02205 c
constant: false
initial amount: NaN
name: prostaglandin-b2
initial concentration: 1.0
boundary condition: false
type: Species
is: SBO:0000247
notes: FORMULA: C20H29O4 CHARGE: -1 INCHI: InChI=1S/C20H30O4/c1-2-3-6-9-17(21)14-12-16-13-15-19(22)18(16)10-7-4-5-8-11-20(23)24/h4,7,12,14,17,21H,2-3,5-6,8-11,13,15H2,1H3,(H,23,24)/b7-4-,14-12+/t17-/m0/s1 EHMN_ABBREVIATION: C05954
has only substance units: false
is: CHEBI:28099

http://identifiers.org/biomodels.db/MODEL1310110042#_537725e1_b0e3_4275_a52b_5d337e01e79c
name: NME1
type: Species
has only substance units: false
boundary condition: true
is: SBO:0000252
initial amount: NaN
constant: false
is encoded by: hsa:4830
initial concentration: NaN

metaR RE2954C
modifier: MODEL1310110042#
reactant: MODEL1310110042#
name: RE2954
is described by: ECO:0000000
product: MODEL1310110042#
notes: GENE_ASSOCIATION: (5315.1) SUBSYSTEM: Pyrimidine synthesis EC Number: 2.7.1.40 Confidence Level: 0 AUTHORS: PMID:10585400,PMID:8967971 NOTES:
is: SBO:0000176
fast: false
type: Reaction
kinetic law: MODEL1310110042#
is version of: http://identifiers.org/ec-code/2.7.1.40
reversible: true

metaR EX taxol LPAREN e RPAREN
kinetic law: MODEL1310110042#
reactant: MODEL1310110042#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: paclitaxel exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110042#_5514f2de_91ce_449e_868f_0ff9caad47be
type: Species
name: FECH
boundary condition: true
constant: false
is: SBO:0000252
initial amount: NaN
initial concentration: NaN
is: P22830
has only substance units: false
is encoded by: hsa:2235

http://identifiers.org/biomodels.db/MODEL1310110042#_6fe96435_b0bd_48a9_8950_9156f625e626
initial concentration: NaN
has only substance units: false
is: SBO:0000252
constant: false
initial amount: NaN
is encoded by: hsa:10449
type: Species
name: ACAA2
is: P42765
boundary condition: true

metaR r0434
notes: GENE_ASSOCIATION: (AI824319.1) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.21 Confidence Level: 0 AUTHORS: PMID:1735445,PMID:1988962,PMID:2355017,PMID:6361812,PMID:7892212 NOTES:
type: Reaction
kinetic law: MODEL1310110042#
is described by: ECO:0000000
reactant: MODEL1310110042#
name: Palmitoyl-CoA:L-carnitine O-palmitoyltransferase Fatty acid metabolism EC:2.3.1.21
reversible: true
is: SBO:0000176
product: MODEL1310110042#
fast: false
modifier: MODEL1310110042#

http://identifiers.org/biomodels.db/MODEL1310110042#_9800860c_f92c_4e18_bc2e_ece70269b039
is encoded by: hsa:56301
initial amount: NaN
initial concentration: NaN
is: SBO:0000252
boundary condition: true
type: Species
constant: false
name: SLC7A10
is: Q9NS82
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110042#_fe8355ec_0845_4887_831c_b93a03e9d1e8
initial amount: NaN
is: SBO:0000252
type: Species
constant: false
name: PLA2G6
boundary condition: true
initial concentration: NaN
is encoded by: hsa:8398
is: O60733
has only substance units: false

metaR ACONTm
is version of: http://identifiers.org/ec-code/4.2.1.3
type: Reaction
is described by: ECO:0000134
reactant: MODEL1310110042#
modifier: MODEL1310110042#
notes: GENE_ASSOCIATION: (50.1) SUBSYSTEM: Citric acid cycle EC Number: 4.2.1.3 Confidence Level: 0 AUTHORS: PMID:10419470,PMID:17244191,PMID:17244192 NOTES:IF. Biochemical
kinetic law: MODEL1310110042#
reversible: true
product: MODEL1310110042#
is: SBO:0000176
fast: false
name: Aconitate hydratase

metaR EX prostge2 LPAREN e RPAREN
kinetic law: MODEL1310110042#
reactant: MODEL1310110042#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Prostaglandin E2 exchange
type: Reaction

metaR ACACT6p
modifier: MODEL1310110042#
is version of: http://identifiers.org/ec-code/2.3.1.16
name: acetyl-CoA C-acetyltransferase (dodecanoyl), peroxisomal
is: SBO:0000176
kinetic law: MODEL1310110042#
is described by: ECO:0000269
reversible: false
product: MODEL1310110042#
type: Reaction
fast: false
notes: GENE_ASSOCIATION: (30.1) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.16 Confidence Level: 4 AUTHORS: PMID:1679347 NOTES:NCD
reactant: MODEL1310110042#

metaM acgal c
constant: false
name: N-acetyl-D-galactosamine
type: Species
notes: FORMULA: C8H15NO6 CHARGE: 0 INCHI: InChI=1S/C8H15NO6/c1-3(11)9-5-7(13)6(12)4(2-10)15-8(5)14/h4-8,10,12-14H,2H2,1H3,(H,9,11)/t4-,5-,6+,7-,8?/m1/s1 EHMN_ABBREVIATION: C01132
is: CHEBI:28037
is: HMDB00212
initial concentration: 1.0
initial amount: NaN
has only substance units: false
is: SBO:0000247
boundary condition: false

metaR EX co2 LPAREN e RPAREN
kinetic law: MODEL1310110042#
reactant: MODEL1310110042#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: CO2 exchange
type: Reaction

metaR EX cmp LPAREN e RPAREN
kinetic law: MODEL1310110042#
reactant: MODEL1310110042#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: CMP exchange
type: Reaction

metaM dcholcoa r
is: CHEBI:28701
boundary condition: false
initial amount: NaN
initial concentration: 1.0
is: HMDB06292
has only substance units: false
is: SBO:0000247
name: chenodeoxycholoyl coenzyme a
notes: FORMULA: C45H70N7O19P3S CHARGE: -4 INCHI: InChI=1S/C45H74N7O19P3S/c1-24(27-7-8-28-34-29(11-14-45(27,28)5)44(4)13-10-26(53)18-25(44)19-30(34)54)6-9-33(56)75-17-16-47-32(55)12-15-48-41(59)38(58)43(2,3)21-68-74(65,66)71-73(63,64)67-20-31-37(70-72(60,61)62)36(57)42(69-31)52-23-51-35-39(46)49-22-50-40(35)52/h22-31,34,36-38,42,53-54,57-58H,6-21H2,1-5H3,(H,47,55)(H,48,59)(H,63,64)(H,65,66)(H2,46,49,50)(H2,60,61,62)/t24-,25+,26-,27-,28+,29+,30-,31-,34+,36-,37-,38+,42-,44+,45-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01426 EHMN_ABBREVIATION: C05337
constant: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110042#_cb939edb_de3e_4603_a613_a63bb97e4cdd
constant: false
boundary condition: true
has only substance units: false
is: Q96PE7
initial amount: NaN
name: MCEE
is: SBO:0000252
initial concentration: NaN
type: Species
is encoded by: hsa:84693

metaM for r
is: C00058
boundary condition: false
is: CHEBI:15740
constant: false
initial amount: NaN
name: Formate
notes: FORMULA: CH1O2 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00061 EHMN_ABBREVIATION: C00058
has only substance units: false
is: HMDB00142
type: Species
is: SBO:0000247
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110042#_b39c87a9_86d0_4416_bc8e_48b1feff86e4
name: UGCG
is: SBO:0000252
has only substance units: false
boundary condition: true
type: Species
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:7357
is: Q16739
constant: false

metaR ALDD2xm
reactant: MODEL1310110042#
fast: false
modifier: MODEL1310110042#
is: SBO:0000176
name: aldehyde dehydrogenase (acetylaldehyde, NAD), mitochondrial
notes: GENE_ASSOCIATION: (219.1) or (217.1) SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: 1.2.1.3 Confidence Level: 0 AUTHORS: PMID:18983992,PMID:18983993,PMID:19382904,PMID:19382905 NOTES:NCD. For NAD
kinetic law: MODEL1310110042#
reversible: false
is version of: http://identifiers.org/ec-code/1.2.1.3
type: Reaction
is described by: ECO:0000134
product: MODEL1310110042#

http://identifiers.org/biomodels.db/MODEL1310110042#_847f676f_a37e_4df9_b354_3d4a52d62d6f
has only substance units: false
boundary condition: true
initial amount: NaN
is: SBO:0000252
is encoded by: hsa:8613
type: Species
is: O14495
initial concentration: NaN
name: PPAP2B
constant: false

metaR r2202
reversible: true
is: SBO:0000185
modifier: MODEL1310110042#
reactant: MODEL1310110042#
product: MODEL1310110042#
kinetic law: MODEL1310110042#
is described by: ECO:0000000
fast: false
notes: GENE_ASSOCIATION: (6566.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.5
type: Reaction

metaM n2m2nmn l
constant: false
is: HMDB00742
initial amount: NaN
has only substance units: false
boundary condition: false
notes: FORMULA: C50H84N4O36 CHARGE: 0
is: CHEBI:17588
initial concentration: 1.0
type: Species
is: SBO:0000247
name: reducing GlcNAc removed form of n2m2nmasn (w/o peptide)

metaM HC02121 c
initial amount: NaN
notes: FORMULA: C11H18N3O7S CHARGE: -1 INCHI: InChI=1S/C11H19N3O7S/c12-6(11(20)21)1-2-8(16)14-7(4-22-5-15)10(19)13-3-9(17)18/h6-7,15H,1-5,12H2,(H,13,19)(H,14,16)(H,17,18)(H,20,21)/p-1/t6-,7-/m0/s1 EHMN_ABBREVIATION: C14180
has only substance units: false
type: Species
is: CHEBI:58758
boundary condition: false
name: S-(hydroxymethyl)glutathione(1-)
initial concentration: 1.0
constant: false
is: SBO:0000247

metaM HC01444 e
initial concentration: 1.0
is: CHEBI:15754
constant: false
type: Species
is: SBO:0000247
initial amount: NaN
boundary condition: false
has only substance units: false
name: Galactosylglycerol
notes: FORMULA: C9H18O8 CHARGE: 0 INCHI: InChI=1S/C9H18O8/c10-1-4(12)3-16-9-8(15)7(14)6(13)5(2-11)17-9/h4-15H,1-3H2/t4-,5-,6+,7+,8-,9-/m1/s1 EHMN_ABBREVIATION: C05401

metaR SEBACACT
kinetic law: MODEL1310110042#
product: MODEL1310110042#
reactant: MODEL1310110042#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: activation of sebacic acidd
type: Reaction

metaM HC02205 e
boundary condition: false
has only substance units: false
initial concentration: 1.0
name: prostaglandin-b2
constant: false
is: CHEBI:28099
is: SBO:0000247
initial amount: NaN
type: Species
notes: FORMULA: C20H29O4 CHARGE: -1 INCHI: InChI=1S/C20H30O4/c1-2-3-6-9-17(21)14-12-16-13-15-19(22)18(16)10-7-4-5-8-11-20(23)24/h4,7,12,14,17,21H,2-3,5-6,8-11,13,15H2,1H3,(H,23,24)/b7-4-,14-12+/t17-/m0/s1 EHMN_ABBREVIATION: C05954

metaR EX 5adtststerone LPAREN e RPAREN
kinetic law: MODEL1310110042#
reactant: MODEL1310110042#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 5alpha-Dihydrotestosterone exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110042#_6a3119a5_c49d_42aa_8c7c_28c97eaa0c1b
initial concentration: NaN
initial amount: NaN
type: Species
is: B2RB47
constant: false
boundary condition: true
is encoded by: hsa:271
name: AMPD2
has only substance units: false
is: SBO:0000252

metaM btn m
constant: false
type: Species
is: HMDB00030
is: CHEBI:57586
notes: FORMULA: C10H15N2O3S CHARGE: -1 INCHI: InChI=1S/C10H16N2O3S/c13-8(14)4-2-1-3-7-9-6(5-16-7)11-10(15)12-9/h6-7,9H,1-5H2,(H,13,14)(H2,11,12,15)/p-1/t6-,7-,9-/m0/s1 EHMN_ABBREVIATION: C00120
initial amount: NaN
name: biotinate
initial concentration: 1.0
has only substance units: false
boundary condition: false
is: SBO:0000247

metaR UREAt
name: Urea transport via facilitate diffusion
type: Reaction
reversible: true
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (6523.1) or (6563.1) or (6528.1) or (8170.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10893432,PMID:11024018,PMID:11034615,PMID:12679487,PMID:12748858,PMID:12856182,PMID:2490366,PMID:8063771,PMID:8559252,PMID:8806637,PMID:9341168 NOTES:JLR
reactant: MODEL1310110042#
fast: false
product: MODEL1310110042#
is: SBO:0000185
modifier: MODEL1310110042#
kinetic law: MODEL1310110042#

http://identifiers.org/biomodels.db/MODEL1310110042#_fce320a9_72cc_4332_94f0_e78e703876c7
type: Species
initial concentration: NaN
boundary condition: true
constant: false
initial amount: NaN
has only substance units: false
name: _AI601100_1_m
is encoded by: hsa:AI601100
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110042#_aa84c521_33f0_4d1f_bdaf_b847a315bf22
boundary condition: true
is: Q9H490
is encoded by: hsa:128869
has only substance units: false
initial amount: NaN
initial concentration: NaN
constant: false
type: Species
name: PIGU
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110042#_ff843021_32d0_4d2f_a546_9e8a67c59404
is: SBO:0000252
is encoded by: hsa:5740
initial concentration: NaN
initial amount: NaN
constant: false
name: PTGIS
is: Q16647
boundary condition: true
has only substance units: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110042#_7aba4674_8584_4b45_91b0_c8d9c1af50ca
is: SBO:0000252
initial concentration: NaN
initial amount: NaN
name: NMNAT2
boundary condition: true
constant: false
has only substance units: false
type: Species
is encoded by: hsa:23057

metaR EX orot LPAREN e RPAREN
kinetic law: MODEL1310110042#
reactant: MODEL1310110042#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of orotate
type: Reaction

metaR r2201
is described by: ECO:0000000
reactant: MODEL1310110042#
notes: GENE_ASSOCIATION: (6566.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
product: MODEL1310110042#
reversible: true
type: Reaction
kinetic law: MODEL1310110042#
fast: false
modifier: MODEL1310110042#
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.5
is: SBO:0000185

metaM 3spyr c
has only substance units: false
type: Species
is: CHEBI:57940
notes: FORMULA: C3H2O6S CHARGE: -2 INCHI: InChI=1S/C3H4O6S/c4-2(3(5)6)1-10(7,8)9/h1H2,(H,5,6)(H,7,8,9)/p-2 EHMN_ABBREVIATION: C05528
initial concentration: 1.0
initial amount: NaN
constant: false
is: SBO:0000247
boundary condition: false
name: 3-sulfonatopyruvate(2-)
is: HMDB04045

metaR UPPN
product: MODEL1310110042#
is: SBO:0000176
is described by: ECO:0000269
kinetic law: MODEL1310110042#
type: Reaction
modifier: MODEL1310110042#
name: b-ureidopropionase
reversible: false
fast: false
reactant: MODEL1310110042#
is version of: http://identifiers.org/ec-code/3.5.1.6
notes: GENE_ASSOCIATION: (51733.1) SUBSYSTEM: Pyrimidine catabolism EC Number: 3.5.1.6 Confidence Level: 4 AUTHORS: PMID:10542323,PMID:12450676 NOTES:SAB balanced

metaR FAOXC164GC163m
kinetic law: MODEL1310110042#
product: MODEL1310110042#
reactant: MODEL1310110042#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C16:4-->C16:3)gm
type: Reaction

metaM adpcoa x
is: C14143
is: SBO:0000247
is: HMDB04047
type: Species
notes: FORMULA: C27H39N7O19P3S CHARGE: -5
name: adipoylcoa
initial amount: NaN
constant: false
initial concentration: 1.0
boundary condition: false
has only substance units: false

metaR ALR3
name: aldose reductase (acetol)
is version of: http://identifiers.org/ec-code/1.1.1.2
is version of: http://identifiers.org/ec-code/1.1.1.21
product: MODEL1310110042#
type: Reaction
is described by: ECO:0000269
reactant: MODEL1310110042#
is: SBO:0000176
reversible: false
kinetic law: MODEL1310110042#
modifier: MODEL1310110042#
fast: false
notes: GENE_ASSOCIATION: (10327.2) or (8574.1) or (10327.1) or (231.1) SUBSYSTEM: Pyruvate metabolism EC Number: 1.1.1.21 Confidence Level: 4 AUTHORS: PMID:12071861,PMID:1537826,PMID:9823300 NOTES:NCD

metaM xylt c
name: xylitol
initial amount: NaN
constant: false
has only substance units: false
is: SBO:0000247
is: HMDB02917
initial concentration: 1.0
type: Species
notes: FORMULA: C5H12O5 CHARGE: 0 INCHI: InChI=1S/C5H12O5/c6-1-3(8)5(10)4(9)2-7/h3-10H,1-2H2/t3-,4+,5+ HEPATONET_1.0_ABBREVIATION: HC00317 EHMN_ABBREVIATION: C00379
boundary condition: false
is: CHEBI:17151

metaM 5homeprazole e
has only substance units: false
notes: FORMULA: C17H19N3O4S CHARGE: 0
type: Species
is: SBO:0000247
is: CHEBI:350546
boundary condition: false
constant: false
initial concentration: 1.0
is: HMDB00259
initial amount: NaN
name: 5 hydroxy omeprazole

metaR MTHFD2
is described by: ECO:0000134
is version of: http://identifiers.org/ec-code/3.5.4.9
reversible: true
product: MODEL1310110042#
notes: GENE_ASSOCIATION: (100287639.1) or (441024.1) SUBSYSTEM: Folate metabolism EC Number: 1.5.1.5 Confidence Level: 2 AUTHORS: PMID:2786332 NOTES:NCD
modifier: MODEL1310110042#
type: Reaction
reactant: MODEL1310110042#
kinetic law: MODEL1310110042#
name: methylenetetrahydrofolate dehydrogenase (NAD)
fast: false
is: SBO:0000176

metaR THYOXt2
notes: GENE_ASSOCIATION: (6567.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12871948,PMID:7981683 NOTES:NJ
is described by: ECO:0000269
reversible: true
modifier: MODEL1310110042#
kinetic law: MODEL1310110042#
fast: false
name: T4 transport via facilitated diffusion
is: SBO:0000185
product: MODEL1310110042#
reactant: MODEL1310110042#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110042#_fcd7d61b_5b0b_491a_964d_122d560c3dff
initial concentration: NaN
is: SBO:0000252
constant: false
type: Species
boundary condition: true
has only substance units: false
initial amount: NaN
name: FOLR1
is encoded by: hsa:2348

metaM Ser Thr l
name: protein-linked serine or threonine residue (O-glycosylation site)
boundary condition: false
initial concentration: 1.0
type: Species
initial amount: NaN
is: HMDB00224
has only substance units: false
constant: false
is: CHEBI:58190
is: SBO:0000247
notes: FORMULA: XH CHARGE: 0

http://identifiers.org/biomodels.db/MODEL1310110042#_211e4a86_e6ee_4e1a_b916_b13380f233d9
constant: false
name: CHKB
boundary condition: true
initial amount: NaN
initial concentration: NaN
has only substance units: false
is encoded by: hsa:1120
type: Species
is: Q9Y259
is: SBO:0000252

metaM tdcoa m
is: C02593
initial concentration: 1.0
notes: FORMULA: C35H58N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00971 EHMN_ABBREVIATION: C02593
is: HMDB01521
initial amount: NaN
boundary condition: false
is: CHEBI:57385
name: Tetradecanoyl-CoA (n-C14:0CoA)
has only substance units: false
is: SBO:0000247
type: Species
constant: false

http://identifiers.org/biomodels.db/MODEL1310110042#_16d48f62_9fc0_4561_9274_1bfec696be2d
is: Q2TU34
initial amount: NaN
is encoded by: hsa:2203
type: Species
constant: false
boundary condition: true
initial concentration: NaN
name: FBP1
has only substance units: false
is: SBO:0000252

metaM oaa c
type: Species
name: Oxaloacetate
initial concentration: 1.0
constant: false
notes: FORMULA: C4H2O5 CHARGE: -2
is: C00036
is: HMDB00223
has only substance units: false
is: CHEBI:3338
initial amount: NaN
boundary condition: false
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110042#_1a7184de_38e0_472e_9583_5425fec5d705
initial amount: NaN
constant: false
name: ADCY4
boundary condition: true
is: Q8NFM4
is encoded by: hsa:196883
is: SBO:0000252
initial concentration: NaN
type: Species
has only substance units: false

metaR ADSL1
is version of: http://identifiers.org/ec-code/4.3.2.2
notes: GENE_ASSOCIATION: (158.1) or (158.2) SUBSYSTEM: Nucleotide interconversion EC Number: 4.3.2.2 Confidence Level: 4 AUTHORS: PMID:1302001,PMID:2004782 NOTES:
product: MODEL1310110042#
kinetic law: MODEL1310110042#
is: SBO:0000176
reversible: false
type: Reaction
name: adenylosuccinate lyase
modifier: MODEL1310110042#
is described by: ECO:0000269
reactant: MODEL1310110042#
fast: false

metaR MALSO3tm
product: MODEL1310110042#
type: Reaction
is described by: ECO:0000269
kinetic law: MODEL1310110042#
is: SBO:0000185
name: Malate:sulfite antiport, mitochondrial
reactant: MODEL1310110042#
notes: GENE_ASSOCIATION: (1468.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172,PMID:4441366 NOTES:MM
fast: false
modifier: MODEL1310110042#
reversible: true

metaR r2200
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.5
reactant: MODEL1310110042#
product: MODEL1310110042#
type: Reaction
is: SBO:0000185
fast: false
notes: GENE_ASSOCIATION: (6566.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
modifier: MODEL1310110042#
reversible: true
is described by: ECO:0000000
kinetic law: MODEL1310110042#

metaR CDIPTr
modifier: MODEL1310110042#
fast: false
is described by: ECO:0000000
is: SBO:0000176
kinetic law: MODEL1310110042#
reversible: true
is version of: http://identifiers.org/ec-code/2.7.8.11
name: phosphatidylinositol synthase (Homo sapiens)
reactant: MODEL1310110042#
type: Reaction
product: MODEL1310110042#
notes: GENE_ASSOCIATION: (10423.1) or (10423.2) SUBSYSTEM: Glycerophospholipid metabolism EC Number: 2.7.8.11 Confidence Level: 4 AUTHORS: PMID:2425833 NOTES:NJ - reversibility of enzyme found in lit by NCD

metaR M4MPDOL Uter
notes: GENE_ASSOCIATION: SUBSYSTEM: N-glycan synthesis EC Number: Confidence Level: 0 AUTHORS: NOTES:
fast: false
reactant: MODEL1310110042#
name: m4mpdol flippase
product: MODEL1310110042#
type: Reaction
reversible: false
kinetic law: MODEL1310110042#
is described by: ECO:0000000
is: SBO:0000185

metaR HXPRT
is version of: http://identifiers.org/ec-code/2.4.2.8
kinetic law: MODEL1310110042#
name: hypoxanthine phosphoribosyltransferase (Hypoxanthine)
fast: false
type: Reaction
modifier: MODEL1310110042#
reversible: false
product: MODEL1310110042#
reactant: MODEL1310110042#
notes: GENE_ASSOCIATION: (3251.1) SUBSYSTEM: Nucleotide salvage pathway EC Number: 2.4.2.8 Confidence Level: 4 AUTHORS: PMID:3008106,PMID:6853490 NOTES:Guanine (see GUAPRT) and 6-mercaptopurine can replace hypoxanthine
is: SBO:0000176
is described by: ECO:0000269

metaM arachd e
boundary condition: false
is: HMDB01043
is: SBO:0000247
notes: FORMULA: C20H31O2 CHARGE: -1 INCHI: InChI=1S/C20H32O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20(21)22/h6-7,9-10,12-13,15-16H,2-5,8,11,14,17-19H2,1H3,(H,21,22)/p-1/b7-6-,10-9-,13-12-,16-15-
name: arachidonate
is: CHEBI:32395
type: Species
initial amount: NaN
initial concentration: 1.0
constant: false
has only substance units: false

metaR EX 3octdeccrn
kinetic law: MODEL1310110042#
reactant: MODEL1310110042#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for 3-hydroxyoctadecanoyl carnitine
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110042#_4375ddaa_117b_45e3_acfb_59d2b0384a1d
name: NDUFA1
initial concentration: NaN
type: Species
initial amount: NaN
boundary condition: true
is: SBO:0000252
is: Q6IBB5
is encoded by: hsa:4694
constant: false
has only substance units: false

metaM g6p c
constant: false
initial amount: NaN
is: HMDB01401
has only substance units: false
name: D-Glucose 6-phosphate
is: C00092
is: SBO:0000247
notes: FORMULA: C6H11O9P CHARGE: -2 INCHI: "1/C5H11/c1-3-5-4-2/h1,3-5H2,2H3 HEPATONET_1.0_ABBREVIATION: HC00094 EHMN_ABBREVIATION: C00092
type: Species
initial concentration: 1.0
boundary condition: false
is: CHEBI:61548

metaR RE3565C
type: Reaction
fast: false
name: RE3565
reversible: true
product: MODEL1310110042#
notes: GENE_ASSOCIATION: SUBSYSTEM: Eicosanoid metabolism EC Number: 5.3.3.9 Confidence Level: 0 AUTHORS: PMID:234423 NOTES:
is: SBO:0000176
is described by: ECO:0000000
reactant: MODEL1310110042#
kinetic law: MODEL1310110042#

metaM chol e
name: Choline
is: HMDB00097
is: C00114
boundary condition: false
constant: false
initial concentration: 1.0
is: CHEBI:15354
type: Species
notes: FORMULA: C5H14NO CHARGE: 1 HEPATONET_1.0_ABBREVIATION: HC00112 EHMN_ABBREVIATION: C00114
has only substance units: false
is: SBO:0000247
initial amount: NaN

metaR ADSL2
notes: GENE_ASSOCIATION: (158.1) or (158.2) SUBSYSTEM: Purine synthesis EC Number: 4.3.2.2 Confidence Level: 4 AUTHORS: PMID:1302001,PMID:2004782 NOTES:
is described by: ECO:0000269
type: Reaction
reactant: MODEL1310110042#
fast: false
product: MODEL1310110042#
kinetic law: MODEL1310110042#
reversible: false
name: adenylosuccinate lyase
modifier: MODEL1310110042#
is version of: http://identifiers.org/ec-code/4.3.2.2
is: SBO:0000176

metaM oxa m
is: CHEBI:30623
is: SBO:0000247
name: oxalate(2-)
has only substance units: false
constant: false
is: HMDB02329
notes: FORMULA: C2O4 CHARGE: -2 INCHI: InChI=1S/C2H2O4/c3-1(4)2(5)6/h(H,3,4)(H,5,6)/p-2 HEPATONET_1.0_ABBREVIATION: HC00195 EHMN_ABBREVIATION: C00209
type: Species
boundary condition: false
initial concentration: 1.0
initial amount: NaN

metaM btn n
initial concentration: 1.0
boundary condition: false
initial amount: NaN
notes: FORMULA: C10H15N2O3S CHARGE: -1 INCHI: InChI=1S/C10H16N2O3S/c13-8(14)4-2-1-3-7-9-6(5-16-7)11-10(15)12-9/h6-7,9H,1-5H2,(H,13,14)(H2,11,12,15)/p-1/t6-,7-,9-/m0/s1 EHMN_ABBREVIATION: C00120
is: CHEBI:57586
name: biotinate
has only substance units: false
type: Species
is: SBO:0000247
constant: false
is: HMDB00030

metaR GBAl
type: Reaction
reactant: MODEL1310110042#
is version of: http://identifiers.org/ec-code/3.2.1.45
is: SBO:0000176
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (2629.4) or (2629.1) or (2629.3) or (2629.2) or (2629.5) SUBSYSTEM: Sphingolipid metabolism EC Number: 3.2.1.45 Confidence Level: 4 AUTHORS: PMID:11933202,PMID:12667141 NOTES:NJ
modifier: MODEL1310110042#
reversible: false
fast: false
product: MODEL1310110042#
name: Glucosylceramidase
kinetic law: MODEL1310110042#

metaM cholp g
initial concentration: 1.0
is: CHEBI:295975
has only substance units: false
boundary condition: false
name: choline phosphate(1-)
notes: FORMULA: C5H13NO4P CHARGE: -1 INCHI: InChI=1S/C5H14NO4P/c1-6(2,3)4-5-10-11(7,8)9/h4-5H2,1-3H3,(H-,7,8,9)/p-1 HEPATONET_1.0_ABBREVIATION: HC00442 EHMN_ABBREVIATION: C00588
is: C00588
constant: false
type: Species
is: SBO:0000247
initial amount: NaN

metaM c4crn m
initial amount: NaN
boundary condition: false
name: butyryl carnitine
initial concentration: 1.0
constant: false
is: HMDB02013
has only substance units: false
is: SBO:0000247
notes: FORMULA: C11H21NO4 CHARGE: 0
type: Species
is: C02862
is: http://identifiers.org/pubchem.compound/213144

metaR DOLPH Ler
notes: GENE_ASSOCIATION: SUBSYSTEM: N-glycan synthesis EC Number: 3.1.3.51 Confidence Level: 0 AUTHORS: PMID:11425794 NOTES:
reversible: false
kinetic law: MODEL1310110042#
fast: false
name: Dolichol-phosphate phosphohydrolase, human (liver)
is described by: ECO:0000000
reactant: MODEL1310110042#
is: SBO:0000176
type: Reaction
product: MODEL1310110042#

metaR AG13T10g
reactant: MODEL1310110042#
kinetic law: MODEL1310110042#
is version of: http://identifiers.org/ec-code/2.4.1.149
is described by: ECO:0000000
product: MODEL1310110042#
fast: false
type: Reaction
reversible: false
modifier: MODEL1310110042#
notes: GENE_ASSOCIATION: (79369.1) or (10678.1) or (11041.1) or (146712.1) or (374907.1) or (93010.1) or (374907.2) or (10331.1) or (10678.2) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.149 Confidence Level: 4 AUTHORS: PMID:10747980,PMID:11042166,PMID:12061784,PMID:12512857,PMID:15560372,PMID:15620693,PMID:9405606 NOTES:NCD
is: SBO:0000176
name: N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase, Golgi apparatus

http://identifiers.org/biomodels.db/MODEL1310110042#_708998c5_2855_49d5_90dc_85e5eef25955
is encoded by: hsa:1109
has only substance units: false
type: Species
constant: false
initial amount: NaN
name: AKR1C4
boundary condition: true
is: SBO:0000252
is: P17516
initial concentration: NaN

metaM ksi e
boundary condition: false
constant: false
name: keratan sulfate I
type: Species
initial amount: NaN
notes: FORMULA: C247H393N17O213S12X CHARGE: -13
has only substance units: false
initial concentration: 1.0
is: HMDB00211
is: CHEBI:17268
is: SBO:0000247

metaM ksi pre15 g
type: Species
notes: FORMULA: C149H240N10O119S4X CHARGE: -5
initial amount: NaN
initial concentration: 1.0
is: CHEBI:58053
constant: false
boundary condition: false
is: SBO:0000247
is: HMDB00175
is: C00130
has only substance units: false
name: keratan sulfate I biosynthesis, precursor 15

metaM ha pre1 l
initial concentration: 1.0
type: Species
initial amount: NaN
is: CHEBI:16126
has only substance units: false
notes: FORMULA: C14H20NO11 CHARGE: -1 INCHI: InChI=1S/C14H21NO11/c1-4(17)15-8-11(10(20)7(3-16)24-13(8)23)26-14-9(19)5(18)2-6(25-14)12(21)22/h2,5,7-11,13-14,16,18-20,23H,3H2,1H3,(H,15,17)(H,21,22)/t5-,7+,8+,9+,10+,11+,13+,14-/m0/s1
is: SBO:0000247
boundary condition: false
constant: false
name: hyaluronan biosynthesis, precursor 1

http://identifiers.org/biomodels.db/MODEL1310110042#_04d8828b_770e_49ef_b070_39ff4e5efbfc
is: Q11203
type: Species
constant: false
boundary condition: true
is: SBO:0000252
has only substance units: false
initial amount: NaN
is encoded by: hsa:6487
name: ST3GAL3
initial concentration: NaN

metaR DUTPDPn
fast: false
is: SBO:0000176
notes: GENE_ASSOCIATION: (1854.1) SUBSYSTEM: Nucleotide interconversion EC Number: 3.6.1.23 Confidence Level: 4 AUTHORS: PMID:12799180,PMID:8631816,PMID:9070952 NOTES:
name: dUTP diphosphatase, nuclear
type: Reaction
reversible: false
is described by: ECO:0000269
kinetic law: MODEL1310110042#
reactant: MODEL1310110042#
product: MODEL1310110042#
modifier: MODEL1310110042#
is version of: http://identifiers.org/ec-code/3.6.1.23

metaR C4STMO1r
name: C-4 sterol methyl oxidase (4,4-dimethylzymosterol)
notes: GENE_ASSOCIATION: (6307.1) SUBSYSTEM: Cholesterol metabolism EC Number: Confidence Level: 4 AUTHORS: NOTES:EC 1.-.-.- NCD ER version NJ
product: MODEL1310110042#
modifier: MODEL1310110042#
type: Reaction
fast: false
is version of: http://identifiers.org/ec-code/1.14.13.72
reactant: MODEL1310110042#
kinetic law: MODEL1310110042#
is described by: ECO:0000000
is: SBO:0000176
reversible: false

metaR PALFATPtc
kinetic law: MODEL1310110042#
product: MODEL1310110042#
reactant: MODEL1310110042#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: uptake of Hexadecanoate by the enterocytes
type: Reaction

metaR B3GNT39g
modifier: MODEL1310110042#
reversible: false
name: UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 3, Golgi apparatus
is described by: ECO:0000000
kinetic law: MODEL1310110042#
product: MODEL1310110042#
reactant: MODEL1310110042#
notes: GENE_ASSOCIATION: (10331.1) SUBSYSTEM: Sphingolipid metabolism EC Number: Confidence Level: 4 AUTHORS: NOTES:NJ
fast: false
type: Reaction
is: SBO:0000176

metaM dcsptn1crn m
constant: false
type: Species
initial concentration: 1.0
notes: FORMULA: C29H47NO4 CHARGE: 0 INCHI: InChI=1/C29H47NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-24-29(33)34-27(25-28(31)32)26-30(2,3)4/h9-10,12-13,15-16,18-19,21-22,27H,5-8,11,14,17,20,23-26H2,1-4H3/b10-9+,13-12+,16-15+,19-18+,22-21+
is: HMDB06321
name: docosa-4,7,10,13,16-pentaenoyl carnitine
has only substance units: false
initial amount: NaN
boundary condition: false
is: SBO:0000247

metaR FAOXC200180x
notes: GENE_ASSOCIATION: (3295.1 and 30.1 and 51.2) or (51.1 and 30.1 and 1962.1) or (51.1 and 3295.1 and 30.1) or (30.1 and 51.2 and 1962.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.74 Confidence Level: 4 AUTHORS: NOTES:peroxisomal (very long chain FA) - in peroxisome, no fad, 1ste set of beta-ox is by acyl-coa oxidase (passes electrons directly to o2 -> h2o2) c20:0 -> c18:0 4 step FAO lumped also includes EC 1.1.1.35, 1.1.1.211, 1.3.3.6, 4.2.1.17, 4.2.1.74 NJ
is version of: http://identifiers.org/ec-code/1.1.1.35
reversible: false
is version of: http://identifiers.org/ec-code/2.3.1.16
is version of: http://identifiers.org/ec-code/1.3.3.6
type: Reaction
is described by: ECO:0000000
name: Beta oxidation of long chain fatty acid
modifier: MODEL1310110042#
kinetic law: MODEL1310110042#
reactant: MODEL1310110042#
fast: false
is: SBO:0000176
product: MODEL1310110042#
is version of: http://identifiers.org/ec-code/4.2.1.107

metaR r0580
is described by: ECO:0000000
product: MODEL1310110042#
modifier: MODEL1310110042#
fast: false
notes: GENE_ASSOCIATION: (AD000092.1) or (2639.1) SUBSYSTEM: CoA synthesis EC Number: 4.1.1.30 Confidence Level: 0 AUTHORS: PMID:13163064 NOTES:
is version of: http://identifiers.org/ec-code/1.3.99.7
is: SBO:0000176
reversible: true
reactant: MODEL1310110042#
name: N-((R)-Pantothenoyl)-L-cysteine carboxy-lyase Pantothenate and CoA biosynthesis EC:4.1.1.30
kinetic law: MODEL1310110042#
type: Reaction

metaR TAURt4 2 r
is: SBO:0000185
reactant: MODEL1310110042#
reversible: true
kinetic law: MODEL1310110042#
name: taurine transport (sodium symport) (2:1)
notes: GENE_ASSOCIATION: (6533.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12719981 NOTES:SAB
modifier: MODEL1310110042#
is described by: ECO:0000269
fast: false
type: Reaction
product: MODEL1310110042#

metaM arachd c
constant: false
is: HMDB01043
notes: FORMULA: C20H31O2 CHARGE: -1 INCHI: InChI=1S/C20H32O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20(21)22/h6-7,9-10,12-13,15-16H,2-5,8,11,14,17-19H2,1H3,(H,21,22)/p-1/b7-6-,10-9-,13-12-,16-15-
name: arachidonate
is: SBO:0000247
is: CHEBI:32395
has only substance units: false
initial concentration: 1.0
type: Species
boundary condition: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110042#_be12d876_0c2b_44c7_a08f_27419684fe76
initial concentration: NaN
boundary condition: true
constant: false
has only substance units: false
type: Species
is encoded by: hsa:6241
is: P31350
initial amount: NaN
is: SBO:0000252
name: RRM2

metaM lneldccoa c
is: HMDB06521
has only substance units: false
name: linoelaidyl coenzyme A
type: Species
initial concentration: 1.0
is: http://identifiers.org/pubchem.compound/9543677
notes: FORMULA: C39H62N7O17P3S CHARGE: -4
is: SBO:0000247
constant: false
initial amount: NaN
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110042#_1b11d8be_2bb8_4593_bb4f_972e98c11a60
initial concentration: NaN
is encoded by: hsa:55163
name: PNPO
is: Q9NVS9
boundary condition: true
initial amount: NaN
constant: false
is: SBO:0000252
type: Species
has only substance units: false

metaR LNELDCCRNt
notes: GENE_ASSOCIATION: (788.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: NOTES:NJ
product: MODEL1310110042#
type: Reaction
is described by: ECO:0000000
fast: false
kinetic law: MODEL1310110042#
name: transport into the mitochondria (carnitine)
modifier: MODEL1310110042#
reversible: false
reactant: MODEL1310110042#
is: SBO:0000185

metaM chol c
name: Choline
is: SBO:0000247
is: HMDB00097
initial amount: NaN
boundary condition: false
is: C00114
initial concentration: 1.0
constant: false
is: CHEBI:15354
has only substance units: false
type: Species
notes: FORMULA: C5H14NO CHARGE: 1 HEPATONET_1.0_ABBREVIATION: HC00112 EHMN_ABBREVIATION: C00114

metaM g3p c
initial amount: NaN
boundary condition: false
is: SBO:0000247
constant: false
notes: FORMULA: C3H5O6P CHARGE: -2 INCHI: " HEPATONET_1.0_ABBREVIATION: HC00116
is: HMDB01112
name: Glyceraldehyde 3-phosphate
initial concentration: 1.0
type: Species
is: http://identifiers.org/pubchem.compound/3930
is: C00661
is: CHEBI:58027
has only substance units: false

metaR FAOXC225x
kinetic law: MODEL1310110042#
product: MODEL1310110042#
reactant: MODEL1310110042#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: isomerization(C22:5)x
type: Reaction

metaR GGH 7THFe
is version of: http://identifiers.org/ec-code/3.4.19.9
kinetic law: MODEL1310110042#
type: Reaction
reversible: false
name: Gamma-glutamyl hydrolase (7THF), extracellular
modifier: MODEL1310110042#
is: SBO:0000176
is described by: ECO:0000000
fast: false
reactant: MODEL1310110042#
notes: GENE_ASSOCIATION: (8836.1) SUBSYSTEM: Folate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:11375437,PMID:2867095,PMID:9614206 NOTES:REMOVES EITHER ONE OR TWO GLUTAMYL RESIDUES WITH A REACTION (WILL ONLY REPRESENT 1) IT
product: MODEL1310110042#

metaM ksii core2 e
constant: false
notes: FORMULA: C81H129N6O67S3X CHARGE: -4
has only substance units: false
name: keratan sulfate II (core 2-linked)
initial amount: NaN
initial concentration: 1.0
is: SBO:0000247
boundary condition: false
is: HMDB00211
is: CHEBI:17268
type: Species

http://identifiers.org/biomodels.db/MODEL1310110042#_95708282_03bb_444a_82b9_bcd2efb338fa
is: SBO:0000252
type: Species
has only substance units: false
is encoded by: hsa:6476
constant: false
name: SI
initial concentration: NaN
initial amount: NaN
is: P14410
boundary condition: true

metaM val L c
is: SBO:0000247
notes: FORMULA: C5H11NO2 CHARGE: 0 INCHI: InChI=1S/C5H11NO2/c1-3(2)4(6)5(7)8/h3-4H,6H2,1-2H3,(H,7,8)/t4-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00174
constant: false
initial concentration: 1.0
name: L-valine
boundary condition: false
is: CHEBI:16414
initial amount: NaN
is: HMDB00883
type: Species
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110042#_95a56ae9_daf6_47b4_ac1d_f99868b1f821
initial concentration: NaN
boundary condition: true
type: Species
is: SBO:0000252
initial amount: NaN
name: PFKL
has only substance units: false
constant: false
is encoded by: hsa:5211
is: P17858

http://identifiers.org/biomodels.db/MODEL1310110042#_1e0ccff9_ea28_4fe2_be18_7280ed557e6d
has only substance units: false
type: Species
name: ALDH1A1
constant: false
initial concentration: NaN
is encoded by: hsa:216
is: P00352
boundary condition: true
initial amount: NaN
is: SBO:0000252

metaR UDPGLCter
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: PMID:10369669 NOTES:NCD
reactant: MODEL1310110042#
kinetic law: MODEL1310110042#
reversible: true
product: MODEL1310110042#
is: SBO:0000185
name: UDP-Glc endoplasmic reticulum transport via CMP antiport
fast: false
is described by: ECO:0000000
type: Reaction

metaM ksi g
notes: FORMULA: C247H393N17O213S12X CHARGE: -13
type: Species
is: CHEBI:17140
boundary condition: false
initial amount: NaN
initial concentration: 1.0
has only substance units: false
name: keratan sulfate I
is: HMDB01644
is: SBO:0000247
constant: false

http://identifiers.org/biomodels.db/MODEL1310110042#_f2387e9a_1a0e_454d_b4e3_c1bbe1f471dc
name: TXNRD1
type: Species
initial concentration: NaN
has only substance units: false
constant: false
initial amount: NaN
is: SBO:0000252
is encoded by: hsa:7296
boundary condition: true

metaM glu5p m
initial concentration: 1.0
has only substance units: false
boundary condition: false
is: HMDB01228
initial amount: NaN
constant: false
is: SBO:0000247
name: L-Glutamate 5-phosphate
notes: FORMULA: C5H8NO7P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC01092 EHMN_ABBREVIATION: C03287
is: CHEBI:58274
type: Species

metaR 34DHPLACOX
reactant: MODEL1310110042#
product: MODEL1310110042#
notes: GENE_ASSOCIATION: (218.1) or (222.1) or (220.1) or (221.1) SUBSYSTEM: Tyrosine metabolism EC Number: 1.2.1.5 Confidence Level: 4 AUTHORS: PMID:11306106,PMID:2071588 NOTES:SAB
is version of: http://identifiers.org/ec-code/1.2.1.5
modifier: MODEL1310110042#
is: SBO:0000176
name: 3,4-Dihydroxyphenylacetaldehyde:NAD+ oxidoreductase
reversible: false
is described by: ECO:0000269
type: Reaction
kinetic law: MODEL1310110042#
fast: false

metaM Ser Thr g
constant: false
name: protein-linked serine or threonine residue (O-glycosylation site)
initial amount: NaN
is: HMDB00645
has only substance units: false
initial concentration: 1.0
boundary condition: false
type: Species
is: SBO:0000247
is: CHEBI:58336
notes: FORMULA: XH CHARGE: 0

metaM dd5ecoa m
type: Species
boundary condition: false
is: HMDB13028
name: 5-dodecenoylcoa
initial concentration: 1.0
notes: FORMULA: C33H52N7O17P3S CHARGE: -4
is: C01942
is: SBO:0000247
initial amount: NaN
has only substance units: false
constant: false

metaR r0871
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14977409 NOTES:
fast: false
kinetic law: MODEL1310110042#
is described by: ECO:0000000
is: SBO:0000185
type: Reaction
reversible: true
reactant: MODEL1310110042#
product: MODEL1310110042#
name: Diffusion

metaR NDP7g
is version of: http://identifiers.org/ec-code/3.6.1.6
product: MODEL1310110042#
reversible: false
type: Reaction
name: nucleoside-diphosphatase (UDP), Golgi apparatus
modifier: MODEL1310110042#
fast: false
is described by: ECO:0000269
is: SBO:0000176
notes: GENE_ASSOCIATION: (9583.1) SUBSYSTEM: Nucleotide interconversion EC Number: 3.6.1.6 Confidence Level: 4 AUTHORS: PMID:10393803,PMID:10858452,PMID:9556635 NOTES:NCD
reactant: MODEL1310110042#
kinetic law: MODEL1310110042#

metaM ahcys m
constant: false
is: C00021
type: Species
is: CHEBI:16680
is: SBO:0000247
initial concentration: 1.0
boundary condition: false
has only substance units: false
notes: FORMULA: C14H20N6O5S CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00031 EHMN_ABBREVIATION: C00021
initial amount: NaN
is: HMDB00939
name: S-Adenosyl-L-homocysteine

metaR PRGNLONESULT
is version of: http://identifiers.org/ec-code/2.8.2.2
kinetic law: MODEL1310110042#
fast: false
product: MODEL1310110042#
is described by: ECO:0000269
modifier: MODEL1310110042#
notes: GENE_ASSOCIATION: (6822.1) or (6820.2) SUBSYSTEM: Steroid metabolism EC Number: 2.8.2.2 Confidence Level: 4 AUTHORS: PMID:12145317,PMID:9799594 NOTES:NJ
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.8.2.14
type: Reaction
reactant: MODEL1310110042#
name: steroid sulfotransferase
reversible: false

metaR MGCHrm
kinetic law: MODEL1310110042#
product: MODEL1310110042#
name: methylglutaconyl-CoA hydratase (reversible), mitochondrial
is version of: http://identifiers.org/ec-code/4.2.1.18
notes: GENE_ASSOCIATION: (549.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 4.2.1.18 Confidence Level: 4 AUTHORS: PMID:12434311,PMID:3082934 NOTES:MM
is described by: ECO:0000269
reversible: true
type: Reaction
fast: false
is: SBO:0000176
modifier: MODEL1310110042#
reactant: MODEL1310110042#

metaR BIOCYTtn
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: PMID:16011464,PMID:5867120,PMID:7758201,PMID:8593541 NOTES:IT
name: biocytin transport, nuclear
kinetic law: MODEL1310110042#
fast: false
is: SBO:0000185
type: Reaction
reactant: MODEL1310110042#
reversible: true
product: MODEL1310110042#

http://identifiers.org/biomodels.db/MODEL1310110042#_7307df54_90b7_4510_815a_15c246be0aeb
name: PIK3R5
has only substance units: false
is: Q8WYR1
type: Species
initial concentration: NaN
is encoded by: hsa:23533
is: SBO:0000252
constant: false
boundary condition: true
initial amount: NaN

metaM paf hs c
constant: false
is: CHEBI:36707
name: 1-alkyl 2-acteylglycerol 3-phosphocholine
initial concentration: 1.0
type: Species
has only substance units: false
is: SBO:0000247
notes: FORMULA: C11H23O4NPFULLRCO2 CHARGE: 0
initial amount: NaN
boundary condition: false

metaM ser D e
is: CHEBI:16523
constant: false
initial concentration: 1.0
boundary condition: false
notes: FORMULA: C3H7NO3 CHARGE: 0 INCHI: InChI=1S/C3H7NO3/c4-2(1-5)3(6)7/h2,5H,1,4H2,(H,6,7)/t2-/m1/s1
initial amount: NaN
type: Species
is: SBO:0000247
is: HMDB03406
has only substance units: false
name: D-serine

metaM lgt S c
constant: false
initial amount: NaN
name: (R)-S-lactoylglutathionate(1-)
is: HMDB01066
is: SBO:0000247
notes: FORMULA: C13H20N3O8S CHARGE: -1 INCHI: InChI=1S/C13H21N3O8S/c1-6(17)13(24)25-5-8(11(21)15-4-10(19)20)16-9(18)3-2-7(14)12(22)23/h6-8,17H,2-5,14H2,1H3,(H,15,21)(H,16,18)(H,19,20)(H,22,23)/p-1/t6-,7+,8+/m1/s1
has only substance units: false
type: Species
is: CHEBI:57474
boundary condition: false
initial concentration: 1.0

metaM tdcoa x
initial concentration: 1.0
initial amount: NaN
name: Tetradecanoyl-CoA (n-C14:0CoA)
is: CHEBI:57385
is: HMDB01521
has only substance units: false
is: C02593
is: SBO:0000247
notes: FORMULA: C35H58N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00971 EHMN_ABBREVIATION: C02593
constant: false
type: Species
boundary condition: false

metaM ru5p D c
is: CHEBI:58121
is: SBO:0000247
initial amount: NaN
type: Species
has only substance units: false
initial concentration: 1.0
boundary condition: false
notes: FORMULA: C5H9O8P CHARGE: -2 INCHI: InChI=1S/C5H11O8P/c6-1-3(7)5(9)4(8)2-13-14(10,11)12/h4-6,8-9H,1-2H2,(H2,10,11,12)/p-2/t4-,5+/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00188
name: D-ribulose 5-phosphate(2-)
constant: false
is: HMDB00618

http://identifiers.org/biomodels.db/MODEL1310110042#_15eec5e7_6cb4_4c25_9489_b43dbef700a2
is: Q01415
is: SBO:0000252
boundary condition: true
has only substance units: false
is encoded by: hsa:2585
name: GALK2
initial amount: NaN
constant: false
type: Species
initial concentration: NaN

metaM thmmp m
type: Species
constant: false
name: thiamine(1+) monophosphate(2-)
is: SBO:0000247
initial amount: NaN
boundary condition: false
notes: FORMULA: C12H16N4O4PS CHARGE: -1 INCHI: InChI=1S/C12H17N4O4PS/c1-8-11(3-4-20-21(17,18)19)22-7-16(8)6-10-5-14-9(2)15-12(10)13/h5,7H,3-4,6H2,1-2H3,(H3-,13,14,15,17,18,19)/p-1 EHMN_ABBREVIATION: C01081
has only substance units: false
is: HMDB02666
is: CHEBI:37575
initial concentration: 1.0

metaR EX 5mta LPAREN e RPAREN
kinetic law: MODEL1310110042#
reactant: MODEL1310110042#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: Exchange of 5-S-methyl-5-thioadenosine
type: Reaction

metaM ksi pre30 g
initial concentration: 1.0
type: Species
is: C00130
has only substance units: false
boundary condition: false
is: CHEBI:58053
is: HMDB00175
constant: false
notes: FORMULA: C219H350N15O184S9X CHARGE: -10
is: SBO:0000247
name: keratan sulfate I biosynthesis, precursor 30
initial amount: NaN

metaR EX prostgi2 LPAREN e RPAREN
kinetic law: MODEL1310110042#
reactant: MODEL1310110042#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: prostaglandin I2(1-) exchange
type: Reaction

metaR RE1533M
modifier: MODEL1310110042#
is: SBO:0000176
type: Reaction
reactant: MODEL1310110042#
is described by: ECO:0000000
reversible: true
notes: GENE_ASSOCIATION: (10449.1) or (3032.1) or (3030.1) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.16 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:7923814,PMID:9568246,PMID:9920399 NOTES:
kinetic law: MODEL1310110042#
is version of: http://identifiers.org/ec-code/4.2.1.17
name: RE1533
fast: false
is version of: http://identifiers.org/ec-code/2.3.1.16
product: MODEL1310110042#

metaM val L e
is: SBO:0000247
notes: FORMULA: C5H11NO2 CHARGE: 0 INCHI: InChI=1S/C5H11NO2/c1-3(2)4(6)5(7)8/h3-4H,6H2,1-2H3,(H,7,8)/t4-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00174
type: Species
name: L-valine
is: HMDB00883
initial concentration: 1.0
has only substance units: false
boundary condition: false
constant: false
initial amount: NaN
is: CHEBI:16414

http://identifiers.org/biomodels.db/MODEL1310110042#_a361f551_1288_4086_984d_944dd53a3902
is encoded by: hsa:117248
is: SBO:0000252
type: Species
is: Q8N3T1
name: GALNTL2
initial amount: NaN
has only substance units: false
constant: false
boundary condition: true
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110042#_460648c1_e30e_45b8_a9e6_c531ed41139e
boundary condition: true
is: P80404
is: SBO:0000252
is encoded by: hsa:18
type: Species
name: ABAT
constant: false
has only substance units: false
initial concentration: NaN
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110042#_dff93893_a3e7_428c_9a07_9187afc9f2ee
name: ACLY
is: SBO:0000252
constant: false
initial concentration: NaN
is: P53396
is encoded by: hsa:47
boundary condition: true
type: Species
initial amount: NaN
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110042#_574a94c2_3c6a_49b6_b5bd_4367b2bb25f5
is encoded by: hsa:8821
is: SBO:0000252
constant: false
is: O15327
initial concentration: NaN
initial amount: NaN
has only substance units: false
boundary condition: true
name: INPP4B
type: Species

metaR r0587
is version of: http://identifiers.org/ec-code/1.2.1.5
notes: GENE_ASSOCIATION: (220.1) or (218.1) or (221.1) or (222.1) or (U37519.1) SUBSYSTEM: Unassigned EC Number: 3.1.3.41 Confidence Level: 0 AUTHORS: PMID:11797369,PMID:1730777,PMID:388794 NOTES:
product: MODEL1310110042#
kinetic law: MODEL1310110042#
modifier: MODEL1310110042#
is described by: ECO:0000000
name: 4-Nitrophenyl phosphate phosphohydrolase gamma-Hexachlorocyclohexane degradation EC:3.1.3.2 EC:3.1.3.41 EC:3.1.3.1
reversible: true
reactant: MODEL1310110042#
fast: false
is: SBO:0000176
type: Reaction

metaR XOL27OHtm
fast: false
reversible: true
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 1 AUTHORS: NOTES:unknown mechanism NJ
reactant: MODEL1310110042#
name: 27 hydroxy cholesterol transport
type: Reaction
product: MODEL1310110042#
is described by: ECO:0000000
kinetic law: MODEL1310110042#

http://identifiers.org/biomodels.db/MODEL1310110042#_1c81d834_14ac_466e_91b1_5cd1a62df4e0
has only substance units: false
type: Species
name: _AA526438_1_c
initial concentration: NaN
boundary condition: true
constant: false
is encoded by: hsa:AA526438
initial amount: NaN
is: SBO:0000252

metaR GLCNACT U
name: UDP-GlcNAc:N-acetyl-D-glucosaminyl diphosphodolichol N-acetyl-D-glucosaminyltransferase (uterus)
reactant: MODEL1310110042#
type: Reaction
reversible: false
is: SBO:0000176
fast: false
product: MODEL1310110042#
is described by: ECO:0000000
kinetic law: MODEL1310110042#
notes: GENE_ASSOCIATION: SUBSYSTEM: N-glycan synthesis EC Number: 2.4.1.141 Confidence Level: 0 AUTHORS: NOTES:

metaR RE2999M
name: RE2999
modifier: MODEL1310110042#
type: Reaction
reactant: MODEL1310110042#
kinetic law: MODEL1310110042#
is version of: http://identifiers.org/ec-code/1.1.1.35
reversible: true
is: SBO:0000176
is version of: http://identifiers.org/ec-code/5.3.3.8
notes: GENE_ASSOCIATION: (1632.1) or (10455.1) or (1962.1) SUBSYSTEM: Fatty acid oxidation EC Number: 5.3.3.8 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:7775433 NOTES:
is described by: ECO:0000000
fast: false
product: MODEL1310110042#

metaM strdnccoa x
name: stearidonyl coenzyme A
initial amount: NaN
notes: FORMULA: C39H58N7O17P3S CHARGE: -4 INCHI: InChI=1/C39H62N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-30(48)67-23-22-41-29(47)20-21-42-37(51)34(50)39(2,3)25-60-66(57,58)63-65(55,56)59-24-28-33(62-64(52,53)54)32(49)38(61-28)46-27-45-31-35(40)43-26-44-36(31)46/h5-6,8-9,11-12,14-15,26-28,32-34,38,49-50H,4,7,10,13,16-25H2,1-3H3,(H,41,47)(H,42,51)(H,55,56)(H,57,58)(H2,40,43,44)(H2,52,53,54)/b6-5-,9-8-,12-11-,15-14-/t28-,32-,33?,34+,38-/m1/s1
initial concentration: 1.0
is: SBO:0000247
is: C16163
boundary condition: false
is: http://identifiers.org/pubchem.compound/47205473
is: HMDB06519
has only substance units: false
type: Species
constant: false

metaM ptdcacrn m
name: pendtadenoyl carnitine
notes: FORMULA: C22H43NO4 CHARGE: 0 INCHI: InChI=1/C22H43NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-22(26)27-20(18-21(24)25)19-23(2,3)4/h20H,5-19H2,1-4H3/t20-/m0/s1
initial concentration: 1.0
is: SBO:0000247
type: Species
has only substance units: false
is: CHEBI:18303
initial amount: NaN
boundary condition: false
constant: false

metaM HC00229 e
name: Isomaltose
is: CHEBI:28189
notes: FORMULA: C12H22O11 CHARGE: 0 INCHI: InChI=1S/C12H22O11/c13-1-4(15)7(17)8(18)5(16)3-22-12-11(21)10(20)9(19)6(2-14)23-12/h1,4-12,14-21H,2-3H2/t4-,5+,6+,7+,8+,9+,10-,11+,12-/m0/s1 EHMN_ABBREVIATION: C00252
constant: false
type: Species
boundary condition: false
has only substance units: false
initial concentration: 1.0
is: SBO:0000247
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110042#_153a9265_e56a_4e7b_8a50_8dd59f90755b
constant: false
initial concentration: NaN
boundary condition: true
type: Species
is: Q9UBQ7
has only substance units: false
initial amount: NaN
name: GRHPR
is encoded by: hsa:9380
is: SBO:0000252

metaR O2tm
product: MODEL1310110042#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 1 AUTHORS: PMID:2551143 NOTES:IF
name: O2 transport (diffusion)
kinetic law: MODEL1310110042#
reversible: true
reactant: MODEL1310110042#
is described by: ECO:0000000
type: Reaction
fast: false
is: SBO:0000185

metaR GLCAASE8ly
notes: GENE_ASSOCIATION: (2990.1) SUBSYSTEM: Hyaluronan metabolism EC Number: 3.2.1.31 Confidence Level: 4 AUTHORS: PMID:3468507,PMID:3924735,PMID:3987656 NOTES:NCD
is: SBO:0000176
reactant: MODEL1310110042#
product: MODEL1310110042#
is version of: http://identifiers.org/ec-code/3.2.1.31
reversible: false
kinetic law: MODEL1310110042#
modifier: MODEL1310110042#
is described by: ECO:0000269
name: beta-glucuronidase, lysosomal
fast: false
type: Reaction

metaM chlstol r
initial concentration: 1.0
type: Species
boundary condition: false
is: HMDB06842
is: CHEBI:16290
is: SBO:0000247
initial amount: NaN
has only substance units: false
name: 5alpha-cholesta-7,24-dien-3beta-ol
constant: false
notes: FORMULA: C27H44O CHARGE: 0 INCHI: InChI=1S/C27H44O/c1-18(2)7-6-8-19(3)23-11-12-24-22-10-9-20-17-21(28)13-15-26(20,4)25(22)14-16-27(23,24)5/h7,10,19-21,23-25,28H,6,8-9,11-17H2,1-5H3/t19-,20+,21+,23-,24+,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01452 EHMN_ABBREVIATION: C05439

metaR r0584
kinetic law: MODEL1310110042#
product: MODEL1310110042#
is version of: http://identifiers.org/ec-code/1.2.1.5
notes: GENE_ASSOCIATION: (220.1) or (218.1) or (221.1) or (222.1) or (U37519.1) SUBSYSTEM: NAD metabolism EC Number: 3.6.1.9 Confidence Level: 0 AUTHORS: PMID:11579996,PMID:11946484 NOTES:
name: Deamino-NAD+ nucleotidohydrolase Nicotinate and nicotinamide metabolism EC:3.6.1.9
is: SBO:0000176
type: Reaction
modifier: MODEL1310110042#
fast: false
reactant: MODEL1310110042#
reversible: true
is described by: ECO:0000000

metaM ser D c
is: HMDB03406
is: CHEBI:16523
initial concentration: 1.0
boundary condition: false
constant: false
notes: FORMULA: C3H7NO3 CHARGE: 0 INCHI: InChI=1S/C3H7NO3/c4-2(1-5)3(6)7/h2,5H,1,4H2,(H,6,7)/t2-/m1/s1
initial amount: NaN
has only substance units: false
name: D-serine
type: Species
is: SBO:0000247

metaR SERHL
type: Reaction
reactant: MODEL1310110042#
product: MODEL1310110042#
is version of: http://identifiers.org/ec-code/4.3.1.17
is described by: ECO:0000269
is: SBO:0000176
reversible: false
name: L-Serine hydro-lyase
kinetic law: MODEL1310110042#
fast: false
notes: GENE_ASSOCIATION: (10993.1) SUBSYSTEM: Glycine, serine, alanine and threonine metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:2674117 NOTES:MM
modifier: MODEL1310110042#

http://identifiers.org/biomodels.db/MODEL1310110042#_d56cc404_87f0_4815_aac2_dd06f86fd843
has only substance units: false
is encoded by: hsa:26
initial concentration: NaN
is: SBO:0000252
is: P19801
name: ABP1
type: Species
boundary condition: true
constant: false
initial amount: NaN

metaM paf hs e
is: CHEBI:36707
initial concentration: 1.0
boundary condition: false
type: Species
is: SBO:0000247
name: 1-alkyl 2-acteylglycerol 3-phosphocholine
has only substance units: false
initial amount: NaN
constant: false
notes: FORMULA: C11H23O4NPFULLRCO2 CHARGE: 0

metaM ksi deg3 l
constant: false
name: keratan sulfate I, degradation product 3
is: HMDB00573
is: CHEBI:30825
has only substance units: false
boundary condition: false
initial amount: NaN
type: Species
is: SBO:0000247
notes: FORMULA: C233H371N16O205S12 CHARGE: -13
initial concentration: 1.0

metaM glygn5 e
is: C00116
is: CHEBI:17754
is: HMDB00131
notes: FORMULA: C12H21O11X CHARGE: 0
boundary condition: false
constant: false
initial amount: NaN
type: Species
initial concentration: 1.0
is: SBO:0000247
has only substance units: false
name: glycogen, structure 5 (glycogenin-2[1,4-Glc])

http://identifiers.org/biomodels.db/MODEL1310110042#_6d4c6863_63ab_4ac9_a029_4f9714d3a2e3
constant: false
is: Q6I9V2
type: Species
boundary condition: true
initial concentration: NaN
name: ATP5C1
is encoded by: hsa:509
has only substance units: false
is: SBO:0000252
initial amount: NaN

metaR BTNt2
fast: false
reversible: true
is: SBO:0000185
reactant: MODEL1310110042#
name: Biotin reversible transport via proton symport
kinetic law: MODEL1310110042#
is described by: ECO:0000269
product: MODEL1310110042#
modifier: MODEL1310110042#
notes: GENE_ASSOCIATION: (6566.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10510291,PMID:12739169,PMID:7835905,PMID:8476015,PMID:9508842,PMID:9649795,PMID:9824713 NOTES:NCD
type: Reaction

metaR r2394
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172 NOTES:
fast: false
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
is described by: ECO:0000000
reactant: MODEL1310110042#
reversible: true
kinetic law: MODEL1310110042#
product: MODEL1310110042#
is: SBO:0000185
type: Reaction

metaM ksii core4 pre4 g
initial concentration: 1.0
initial amount: NaN
boundary condition: false
is: SBO:0000247
notes: FORMULA: C61H99N5O43X CHARGE: -1
is: CHEBI:58053
constant: false
has only substance units: false
type: Species
is: HMDB00175
is: C00130
name: keratan sulfate II biosynthesis, precursor 4

metaR GLYCTO1p
is: SBO:0000176
reversible: false
modifier: MODEL1310110042#
product: MODEL1310110042#
notes: GENE_ASSOCIATION: (51179.1) or (54363.1) or (51179.2) SUBSYSTEM: Glyoxylate and dicarboxylate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:10777549,PMID:4705431,PMID:9038835 NOTES:tv NCD
fast: false
is version of: http://identifiers.org/ec-code/1.1.3.15
type: Reaction
kinetic law: MODEL1310110042#
is described by: ECO:0000269
reactant: MODEL1310110042#
name: Glycolate oxidase, peroxisome

http://identifiers.org/biomodels.db/MODEL1310110042#_7732fb7a_6629_4c68_881f_f8dd3c0927d8
name: ABCC5
is: SBO:0000252
initial amount: NaN
is: O15440
type: Species
boundary condition: true
is encoded by: hsa:10057
constant: false
initial concentration: NaN
has only substance units: false

metaM btn c
type: Species
initial concentration: 1.0
is: HMDB00030
constant: false
is: SBO:0000247
has only substance units: false
is: CHEBI:3420
boundary condition: false
name: Biotin
notes: FORMULA: C10H15N2O3S CHARGE: -1
is: C00120
initial amount: NaN

metaM CE4795 x
boundary condition: false
constant: false
initial concentration: 1.0
initial amount: NaN
notes: FORMULA: C41H60N7O17P3S CHARGE: -4 INCHI: InChI=1/C41H64N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-32(50)69-25-24-43-31(49)22-23-44-39(53)36(52)41(2,3)27-62-68(59,60)65-67(57,58)61-26-30-35(64-66(54,55)56)34(51)40(63-30)48-29-47-33-37(42)45-28-46-38(33)48/h8-9,11-12,14-15,18-21,28-30,34-36,40,51-52H,4-7,10,13,16-17,22-27H2,1-3H3,(H,43,49)(H,44,53)(H,57,58)(H,59,60)(H2,42,45,46)(H2,54,55,56)/p-4/b9-8-,12-11-,15-14-,19-18-,21-20+/t30-,34+,35+,36u,40-/m0/s1 EHMN_ABBREVIATION: CE4795
type: Species
name: 2-trans-cis,cis,cis,cis-4,8,11,14-eicosapentaenoyl-CoA
is: CHEBI:57923
is: SBO:0000247
has only substance units: false

metaR r0660
reversible: true
name: (S)-3-Hydroxydodecanoyl-CoA hydro-lyase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:4.2.1.17
product: MODEL1310110042#
fast: false
type: Reaction
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/1.5.1.2
kinetic law: MODEL1310110042#
is: SBO:0000176
reactant: MODEL1310110042#
notes: GENE_ASSOCIATION: (10637.1) or (5831.1) or (29920.1) or (65263.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.17 Confidence Level: 0 AUTHORS: PMID:8012501,PMID:8188243 NOTES:
modifier: MODEL1310110042#

metaR GLU5Km
notes: GENE_ASSOCIATION: (5832.1) SUBSYSTEM: Urea cycle EC Number: 2.7.2.11 Confidence Level: 2 AUTHORS: PMID:10037775 NOTES:SAB m
reversible: false
product: MODEL1310110042#
reactant: MODEL1310110042#
modifier: MODEL1310110042#
kinetic law: MODEL1310110042#
is: SBO:0000176
name: glutamate 5-kinase (m)
type: Reaction
fast: false
is described by: ECO:0000254
is version of: http://identifiers.org/ec-code/1.2.1.41

metaR r0661
reversible: false
name: (S)-3-Hydroxydodecanoyl-CoA hydro-lyase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:4.2.1.17
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.17 Confidence Level: 0 AUTHORS: PMID:8012501,PMID:8188243 NOTES:
type: Reaction
product: MODEL1310110042#
fast: false
is described by: ECO:0000000
reactant: MODEL1310110042#
kinetic law: MODEL1310110042#
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110042#_587ae64e_395b_425e_b14e_8029b13870f6
is encoded by: hsa:10559
initial amount: NaN
is: SBO:0000252
has only substance units: false
name: SLC35A1
constant: false
boundary condition: true
initial concentration: NaN
is: P78382
type: Species

metaR 4PYRDX
is: SBO:0000185
reactant: MODEL1310110042#
reversible: false
type: Reaction
product: MODEL1310110042#
is described by: ECO:0000000
kinetic law: MODEL1310110042#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:6380540 NOTES:IT Reaction correct??? (active transport)
name: 4-Pyridoxal secretion
fast: false

metaM orot e
initial amount: NaN
name: orotate
constant: false
is: SBO:0000247
is: HMDB00226
initial concentration: 1.0
type: Species
notes: FORMULA: C5H3N2O4 CHARGE: -1 INCHI: InChI=1S/C5H4N2O4/c8-3-1-2(4(9)10)6-5(11)7-3/h1H,(H,9,10)(H2,6,7,8,11)/p-1 HEPATONET_1.0_ABBREVIATION: HC00256 EHMN_ABBREVIATION: C00295
is: CHEBI:30839
boundary condition: false
has only substance units: false

metaM 10fthf m
constant: false
boundary condition: false
is: HMDB00972
is: SBO:0000247
name: 10-formyltetrahydrofolate(2-)
initial concentration: 1.0
type: Species
initial amount: NaN
notes: FORMULA: C20H21N7O7 CHARGE: -2 INCHI: InChI=1S/C20H23N7O7/c21-20-25-16-15(18(32)26-20)23-11(7-22-16)8-27(9-28)12-3-1-10(2-4-12)17(31)24-13(19(33)34)5-6-14(29)30/h1-4,9,11,13,23H,5-8H2,(H,24,31)(H,29,30)(H,33,34)(H4,21,22,25,26,32)/p-2/t11-,13+/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00212 EHMN_ABBREVIATION: C00234
is: CHEBI:57454
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110042#_08624adb_3341_481a_b129_640116d29d9e
initial concentration: NaN
is encoded by: hsa:51022
name: GLRX2
has only substance units: false
constant: false
initial amount: NaN
is: Q9NS18
is: SBO:0000252
boundary condition: true
type: Species

metaM ksi l
is: SBO:0000247
name: keratan sulfate I
is: C00445
constant: false
is: CHEBI:57455
initial amount: NaN
is: HMDB01354
type: Species
notes: FORMULA: C247H393N17O213S12X CHARGE: -13
boundary condition: false
initial concentration: 1.0
has only substance units: false

metaM 3ttetddcoacrn e
is: SBO:0000247
constant: false
has only substance units: false
initial concentration: 1.0
name: 3-hydroxy trans5,8tetradecadienoyl carnitine
is: HMDB02014
boundary condition: false
notes: FORMULA: C21H37NO5 CHARGE: 0
initial amount: NaN
type: Species

metaR OAGT3te
product: MODEL1310110042#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 1 AUTHORS: PMID:8206147 NOTES:unknown mechanism for transport - intracellular transport occurs, most details are unknown - see for example Varki glycobiology text or numerous reviews (PMID: 8206147) - extracellular transport is also made available since metabolites can get to outer plasma membrane NJ
name: oagt3 hs transport
reversible: true
is: SBO:0000185
kinetic law: MODEL1310110042#
type: Reaction
reactant: MODEL1310110042#
is described by: ECO:0000000

metaR TETPENT6COAtx
kinetic law: MODEL1310110042#
fast: false
name: fatty acid intracellular transport
is described by: ECO:0000000
is: SBO:0000185
product: MODEL1310110042#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 0 AUTHORS: NOTES:interaction between peroxisomes and ER (some enzymes on the outer membrane) NJ
type: Reaction
reversible: true
reactant: MODEL1310110042#

http://identifiers.org/biomodels.db/MODEL1310110042#_2f11a34b_f89e_4559_be75_7f5a3d523928
initial concentration: NaN
initial amount: NaN
name: _AI694761_1_c
has only substance units: false
boundary condition: true
is encoded by: hsa:AI694761
type: Species
is: SBO:0000252
constant: false

metaR r1800
type: Reaction
reversible: false
reactant: MODEL1310110042#
kinetic law: MODEL1310110042#
is: SBO:0000185
fast: false
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
name: Y+LAT2 Utilized transport
modifier: MODEL1310110042#
is described by: ECO:0000000
product: MODEL1310110042#

metaR FAOXC16C16OHm
kinetic law: MODEL1310110042#
product: MODEL1310110042#
reactant: MODEL1310110042#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C16-->C16OH)m
type: Reaction

metaM HC01414 x
is: SBO:0000247
is: CHEBI:61406
type: Species
name: trans-dec-2-enoyl-CoA(4-)
notes: FORMULA: C31H48N7O17P3S CHARGE: -4 INCHI: InChI=1S/C31H52N7O17P3S/c1-4-5-6-7-8-9-10-11-22(40)59-15-14-33-21(39)12-13-34-29(43)26(42)31(2,3)17-52-58(49,50)55-57(47,48)51-16-20-25(54-56(44,45)46)24(41)30(53-20)38-19-37-23-27(32)35-18-36-28(23)38/h10-11,18-20,24-26,30,41-42H,4-9,12-17H2,1-3H3,(H,33,39)(H,34,43)(H,47,48)(H,49,50)(H2,32,35,36)(H2,44,45,46)/p-4/b11-10+/t20-,24-,25-,26+,30-/m1/s1 EHMN_ABBREVIATION: C05275
boundary condition: false
initial concentration: 1.0
constant: false
has only substance units: false
initial amount: NaN

metaR PHETHPTOX2
name: L-Phenylalanine,tetrahydrobiopterin:oxygen oxidoreductase (4-hydroxylating)
is: SBO:0000176
is described by: ECO:0000269
fast: false
reversible: false
kinetic law: MODEL1310110042#
type: Reaction
reactant: MODEL1310110042#
modifier: MODEL1310110042#
product: MODEL1310110042#
is version of: http://identifiers.org/ec-code/1.14.16.1
notes: GENE_ASSOCIATION: (5053.1) SUBSYSTEM: Phenylalanine metabolism EC Number: 1.14.16.1 Confidence Level: 4 AUTHORS: PMID:10727395,PMID:9450897 NOTES:SAB unlumped form of PHETHPTOX according to PMID 10727395

http://identifiers.org/biomodels.db/MODEL1310110042#_82ab830f_9d63_4d13_bd33_6a5dee26e6c2
name: CBR1
boundary condition: true
constant: false
type: Species
initial concentration: NaN
is: P16152
initial amount: NaN
has only substance units: false
is: SBO:0000252
is encoded by: hsa:873

metaR URATEt
is described by: ECO:0000000
type: Reaction
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:IT
is: SBO:0000185
product: MODEL1310110042#
reactant: MODEL1310110042#
kinetic law: MODEL1310110042#
reversible: false
name: urate export from cytosol

http://identifiers.org/biomodels.db/MODEL1310110042#_f18fc1b5_994a_481c_b7f5_b95b2290101a
is encoded by: hsa:5334
initial concentration: NaN
constant: false
is: Q15111
type: Species
has only substance units: false
is: SBO:0000252
initial amount: NaN
name: PLCL1
boundary condition: true

metaR LEUTA
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (586.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 2.6.1.6 Confidence Level: 4 AUTHORS: PMID:6933702,PMID:9165094 NOTES:_2.6.1.42
type: Reaction
reactant: MODEL1310110042#
is version of: http://identifiers.org/ec-code/2.6.1.42
modifier: MODEL1310110042#
reversible: true
product: MODEL1310110042#
kinetic law: MODEL1310110042#
fast: false
name: leucine transaminase
is: SBO:0000176

metaM 5homeprazole c
constant: false
is: SBO:0000247
boundary condition: false
has only substance units: false
initial concentration: 1.0
initial amount: NaN
type: Species
is: CHEBI:350546
notes: FORMULA: C17H19N3O4S CHARGE: 0
name: 5 hydroxy omeprazole
is: HMDB00259

http://identifiers.org/biomodels.db/MODEL1310110042#_2eaae91d_8e05_4f24_870d_50c16a70a478
initial amount: NaN
is: P33897
is: SBO:0000252
initial concentration: NaN
type: Species
boundary condition: true
has only substance units: false
is encoded by: hsa:215
constant: false
name: ABCD1

metaR GUAt
name: Guanine transport
modifier: MODEL1310110042#
fast: false
is described by: ECO:0000269
is: SBO:0000185
reversible: true
kinetic law: MODEL1310110042#
product: MODEL1310110042#
type: Reaction
reactant: MODEL1310110042#
notes: GENE_ASSOCIATION: (3177.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12006583,PMID:12838422 NOTES:JLR

http://identifiers.org/biomodels.db/MODEL1310110042#_44160eee_74a9_4b07_acd3_6c0e2b6d89e6
is encoded by: hsa:9091
type: Species
boundary condition: true
is: SBO:0000252
name: PIGQ
initial amount: NaN
is: B2RAU6
has only substance units: false
constant: false
initial concentration: NaN

metaR ARACHCOAtx
fast: false
reactant: MODEL1310110042#
is described by: ECO:0000000
kinetic law: MODEL1310110042#
reversible: true
is: SBO:0000185
type: Reaction
product: MODEL1310110042#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: NOTES:interaction between peroxisomes and ER (some enzymes on the outer membrane) NJ
name: fatty acid intracellular transport

metaM ksii core2 deg8 l
is: HMDB00143
has only substance units: false
boundary condition: false
is: SBO:0000247
initial concentration: 1.0
constant: false
type: Species
initial amount: NaN
is: CHEBI:12936
notes: FORMULA: C36H60N3O25X CHARGE: 0
name: keratan sulfate II (core 2-linked), degradation product 8

metaM btn e
constant: false
is: CHEBI:3420
is: SBO:0000247
initial concentration: 1.0
initial amount: NaN
has only substance units: false
notes: FORMULA: C10H15N2O3S CHARGE: -1
is: C00120
type: Species
boundary condition: false
name: Biotin
is: HMDB00030

metaR PERILLYLte
type: Reaction
is: SBO:0000185
product: MODEL1310110042#
reversible: true
fast: false
name: xenobiotic transport
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 1 AUTHORS: NOTES:unknown mechanism, xenobiotic transport (original and metabolized) NJ
kinetic law: MODEL1310110042#
is described by: ECO:0000000
reactant: MODEL1310110042#

http://identifiers.org/biomodels.db/MODEL1310110042#_1118e52d_8516_4157_860e_72475e82c7f1
has only substance units: false
constant: false
is encoded by: hsa:10195
boundary condition: true
is: SBO:0000252
initial amount: NaN
initial concentration: NaN
name: ALG3
is: Q92685
type: Species

http://identifiers.org/biomodels.db/MODEL1310110042#_c9bcf42a_9b28_431c_a9b8_46eff227f27b
is: SBO:0000252
initial concentration: NaN
name: LDHB
has only substance units: false
is encoded by: hsa:3945
initial amount: NaN
constant: false
is: P07195
type: Species
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110042#_563b92da_869d_46a4_b5f8_c422cc4b1b0b
is: Q8N3E9
is encoded by: hsa:113026
initial amount: NaN
is: SBO:0000252
boundary condition: true
initial concentration: NaN
has only substance units: false
constant: false
type: Species
name: PLCD3

metaM l2fn2m2masn g
initial concentration: 1.0
type: Species
name: {[galactosyl-(1,4)-N-Acetyl-glucosaminyl-(1,2)-mannosyl-(1,3)-],[N-acetyl-glucosaminyl-(1,2)-mannosyl-(1,6)-]mannosyl-(1,4)-N-acetyl-glucosaminyl-(1,4)-[fucosyl-(1,6)]-N-acetyl-glucosaminyl}asparagine
notes: FORMULA: C68H113N4O49X CHARGE: 0
is: SBO:0000247
has only substance units: false
boundary condition: false
constant: false
initial amount: NaN
is: CHEBI:28067

metaM 3ttetddcoacrn c
has only substance units: false
initial concentration: 1.0
name: 3-hydroxy trans5,8tetradecadienoyl carnitine
is: SBO:0000247
constant: false
boundary condition: false
is: HMDB02014
notes: FORMULA: C21H37NO5 CHARGE: 0
type: Species
initial amount: NaN

metaM 3hddcoa c
initial amount: NaN
type: Species
is: HMDB00623
initial concentration: 1.0
boundary condition: false
constant: false
has only substance units: false
name: (S)-3-Hydroxydodecanoyl-CoA
is: SBO:0000247
notes: FORMULA: C33H54N7O18P3S CHARGE: -4

metaR OAGT3tg
reactant: MODEL1310110042#
product: MODEL1310110042#
name: oagt3 hs intracellular transport
kinetic law: MODEL1310110042#
is: SBO:0000185
fast: false
type: Reaction
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 1 AUTHORS: PMID:8206147 NOTES:unknown mechanism for transport - intracellular transport occurs, most details are unknown - see for example Varki glycobiology text or numerous reviews (PMID: 8206147) NJ
reversible: true

metaR FACOAL1813
fast: false
is version of: http://identifiers.org/ec-code/6.2.1.3
is described by: ECO:0000269
product: MODEL1310110042#
kinetic law: MODEL1310110042#
modifier: MODEL1310110042#
reactant: MODEL1310110042#
notes: GENE_ASSOCIATION: (2180.1) SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 4 AUTHORS: PMID:15292367 NOTES:NJ
is: SBO:0000176
type: Reaction
name: fatty-acid--CoA ligase
reversible: true

metaM hdd2coa m
is: HMDB03945
type: Species
constant: false
is: SBO:0000247
name: trans-Hexadec-2-enoyl-CoA
initial amount: NaN
initial concentration: 1.0
has only substance units: false
notes: FORMULA: C37H60N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC01411 EHMN_ABBREVIATION: C05272
is: CHEBI:61526
boundary condition: false
is: C05272

metaM CE4724 e
is: SBO:0000247
notes: FORMULA: C60H105N22O15S CHARGE: 3 INCHI: InChI=1/C60H102N22O15S/c1-33(2)27-40(77-50(88)37(12-6-21-69-59(64)65)74-55(93)44-15-9-24-81(44)56(94)38(13-7-22-70-60(66)67)75-48(86)35(62)17-18-46(63)84)51(89)79-42(31-83)53(91)78-41(28-34-29-68-32-72-34)52(90)73-36(11-4-5-20-61)49(87)71-30-47(85)80-23-8-14-43(80)54(92)76-39(19-26-98-3)57(95)82-25-10-16-45(82)58(96)97/h29,32-33,35-45,83H,4-28,30-31,61-62H2,1-3H3,(H2,63,84)(H,68,72)(H,71,87)(H,73,90)(H,74,93)(H,75,86)(H,76,92)(H,77,88)(H,78,91)(H,79,89)(H,96,97)(H4,64,65,69)(H4,66,67,70)/p+3/t35-,36-,37-,38+,39-,40+,41+,42-,43+,44+,45-/m1/s1 EHMN_ABBREVIATION: CE4724
initial amount: NaN
is: http://identifiers.org/pubchem.compound/5041
initial concentration: 1.0
name: apelin (1-12)
type: Species
constant: false
boundary condition: false
is: C01936
has only substance units: false

metaM m8mpdol L r
constant: false
notes: FORMULA: C1780H2928N20O620P20 CHARGE: -20 INCHI: InChI=1S/C95H162N2O62P2/c1-34(2)13-9-14-35(3)15-10-16-36(4)17-11-18-37(5)19-12-20-38(6)21-22-138-160(132,133)159-161(134,135)158-86-53(97-40(8)108)64(119)77(49(31-106)147-86)150-85-52(96-39(7)107)63(118)78(48(30-105)146-85)151-91-76(131)80(153-94-84(71(126)60(115)46(28-103)144-94)157-95-83(70(125)59(114)47(29-104)145-95)156-90-74(129)67(122)56(111)43(25-100)141-90)62(117)51(149-91)32-136-87-75(130)79(152-93-82(69(124)58(113)45(27-102)143-93)155-89-73(128)66(121)55(110)42(24-99)140-89)61(116)50(148-87)33-137-92-81(68(123)57(112)44(26-101)142-92)154-88-72(127)65(120)54(109)41(23-98)139-88/h13,15,17,19,38,41-95,98-106,109-131H,9-12,14,16,18,20-33H2,1-8H3,(H,96,107)(H,97,108)(H,132,133)(H,134,135)/b35-15+,36-17+,37-19+/t38?,41-,42-,43-,44-,45-,46-,47-,48-,49-,50-,51-,52-,53-,54-,55-,56-,57-,58-,59-,60-,61-,62-,63-,64-,65+,66+,67+,68+,69+,70+,71+,72+,73+,74+,75+,76+,77-,78-,79+,80+,81+,82+,83+,84+,85+,86-,87+,88-,89-,90-,91+,92+,93-,94-,95-/m1/s1 EHMN_ABBREVIATION: C05868
is: CHEBI:59093
is: SBO:0000247
has only substance units: false
initial concentration: 1.0
initial amount: NaN
type: Species
name: (alpha-D-Mannosyl)8-beta-D-mannosyl-diacetylchitobiosyldiphosphodolichol, human liver homolog
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110042#_151d03fc_fc9d_40df_805c_83fdb235326d
initial concentration: NaN
boundary condition: true
is: P42765
is encoded by: hsa:10449
initial amount: NaN
constant: false
type: Species
name: ACAA2
is: SBO:0000252
has only substance units: false

metaR ADRNCPT2
is described by: ECO:0000000
reversible: false
fast: false
modifier: MODEL1310110042#
notes: GENE_ASSOCIATION: (1376.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: NOTES:NJ
name: carnitine transferase
type: Reaction
is: SBO:0000176
product: MODEL1310110042#
is version of: http://identifiers.org/ec-code/2.3.1.21
reactant: MODEL1310110042#
kinetic law: MODEL1310110042#

metaR EX 5homeprazole LPAREN e RPAREN
kinetic law: MODEL1310110042#
reactant: MODEL1310110042#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 5 hydroxy omeprazole exchange
type: Reaction

metaR G6PDH2r
is version of: http://identifiers.org/ec-code/1.1.1.49
product: MODEL1310110042#
is: SBO:0000176
fast: false
name: glucose 6-phosphate dehydrogenase
type: Reaction
notes: GENE_ASSOCIATION: (2539.1) SUBSYSTEM: Pentose phosphate pathway EC Number: 1.1.1.49 Confidence Level: 0 AUTHORS: NOTES:JLR - a reversible reaction that is otherwise identical to ZWF
kinetic law: MODEL1310110042#
reversible: true
is described by: ECO:0000000
modifier: MODEL1310110042#
reactant: MODEL1310110042#

metaR GLCNACPT U
product: MODEL1310110042#
is version of: http://identifiers.org/ec-code/2.7.8.15
is described by: ECO:0000000
kinetic law: MODEL1310110042#
name: UDP-GlcNAc:dolichol-phosphate GlcNAc phosphotransferase (uterus)
type: Reaction
fast: false
reactant: MODEL1310110042#
reversible: false
modifier: MODEL1310110042#
is: SBO:0000176
notes: GENE_ASSOCIATION: (1798.1) or (1798.2) SUBSYSTEM: N-glycan synthesis EC Number: 2.7.8.15 Confidence Level: 0 AUTHORS: NOTES:NCD

metaM dcholcoa x
notes: FORMULA: C45H70N7O19P3S CHARGE: -4 INCHI: InChI=1S/C45H74N7O19P3S/c1-24(27-7-8-28-34-29(11-14-45(27,28)5)44(4)13-10-26(53)18-25(44)19-30(34)54)6-9-33(56)75-17-16-47-32(55)12-15-48-41(59)38(58)43(2,3)21-68-74(65,66)71-73(63,64)67-20-31-37(70-72(60,61)62)36(57)42(69-31)52-23-51-35-39(46)49-22-50-40(35)52/h22-31,34,36-38,42,53-54,57-58H,6-21H2,1-5H3,(H,47,55)(H,48,59)(H,63,64)(H,65,66)(H2,46,49,50)(H2,60,61,62)/t24-,25+,26-,27-,28+,29+,30-,31-,34+,36-,37-,38+,42-,44+,45-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01426 EHMN_ABBREVIATION: C05337
name: chenodeoxycholoyl coenzyme a
is: HMDB06292
initial amount: NaN
constant: false
type: Species
is: SBO:0000247
boundary condition: false
is: CHEBI:28701
initial concentration: 1.0
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110042#_81282033_2bc7_4e92_afc7_181eb645271c
is: Q9NYR8
initial concentration: NaN
is encoded by: hsa:50700
is: SBO:0000252
has only substance units: false
boundary condition: true
constant: false
type: Species
initial amount: NaN
name: RDH8

metaM doco13ecoa x
has only substance units: false
constant: false
is: http://identifiers.org/pubchem.compound/24892791
notes: FORMULA: C43H72N7O17P3S CHARGE: -4
initial concentration: 1.0
boundary condition: false
type: Species
name: 13-docosenoylcoa
initial amount: NaN
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110042#_c7009a39_b84b_4f8f_8a05_bb2a9ff78fb6
constant: false
is: SBO:0000252
initial concentration: NaN
type: Species
initial amount: NaN
is: P26439
name: HSD3B2
is encoded by: hsa:3284
boundary condition: true
has only substance units: false

metaM c101coa c
boundary condition: false
is: HMDB04047
name: decenoylcoa
type: Species
has only substance units: false
initial concentration: 1.0
constant: false
is: SBO:0000247
is: C14143
notes: FORMULA: C31H48N7O17P3S CHARGE: -4
initial amount: NaN

metaM pail34p hs c
initial concentration: 1.0
constant: false
initial amount: NaN
notes: FORMULA: C9H14O15P3FULLRCO2FULLR2CO2 CHARGE: -5
type: Species
is: CHEBI:57658
name: 1-phosphatidyl-1D-myo-inositol 3,4-bisphosphate(5-)
is: SBO:0000247
boundary condition: false
has only substance units: false

metaR HTDCACBP
kinetic law: MODEL1310110042#
product: MODEL1310110042#
reactant: MODEL1310110042#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: transport of (S)-3-Hydroxytetradecanoyl-CoA from mitochondria into the cytosol
type: Reaction

metaM dhlam m
constant: false
initial amount: NaN
notes: FORMULA: C8H17NOS2 CHARGE: 0 INCHI: InChI=1S/C8H17NOS2/c9-8(10)4-2-1-3-7(12)5-6-11/h7,11-12H,1-6H2,(H2,9,10) HEPATONET_1.0_ABBREVIATION: HC00437 EHMN_ABBREVIATION: C00579
type: Species
initial concentration: 1.0
is: HMDB00985
is: CHEBI:17694
has only substance units: false
boundary condition: false
name: dihydrolipoamide
is: SBO:0000247

metaR r1801
product: MODEL1310110042#
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
name: Y+LAT2 Utilized transport
reversible: false
reactant: MODEL1310110042#
is: SBO:0000185
is described by: ECO:0000000
kinetic law: MODEL1310110042#
modifier: MODEL1310110042#
type: Reaction
fast: false

metaR FACOAL1812
modifier: MODEL1310110042#
reversible: true
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/6.2.1.3
reactant: MODEL1310110042#
name: fatty-acid--CoA ligase
product: MODEL1310110042#
is: SBO:0000176
type: Reaction
notes: GENE_ASSOCIATION: (2180.1) SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 4 AUTHORS: PMID:15292367 NOTES:NJ
kinetic law: MODEL1310110042#
fast: false

metaR XOL7AONEtr
kinetic law: MODEL1310110042#
is: SBO:0000185
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: PMID:12840657 NOTES:cholesterol precursor, transport by "diffusion" -> actually beleived to be flip-flop mechanism (PMID: 12840657). NJ
name: lipid, flip-flop intracellular transport
fast: false
product: MODEL1310110042#
is described by: ECO:0000000
type: Reaction
reactant: MODEL1310110042#

http://identifiers.org/biomodels.db/MODEL1310110042#_53f07887_e987_4999_96e7_7c170aee8b0e
has only substance units: false
name: SLC2A12
initial concentration: NaN
is encoded by: hsa:154091
type: Species
is: SBO:0000252
initial amount: NaN
is: Q8TD20
boundary condition: true
constant: false

metaM ha pre1 e
name: hyaluronan biosynthesis, precursor 1
constant: false
boundary condition: false
initial concentration: 1.0
is: CHEBI:16126
is: SBO:0000247
notes: FORMULA: C14H20NO11 CHARGE: -1 INCHI: InChI=1S/C14H21NO11/c1-4(17)15-8-11(10(20)7(3-16)24-13(8)23)26-14-9(19)5(18)2-6(25-14)12(21)22/h2,5,7-11,13-14,16,18-20,23H,3H2,1H3,(H,15,17)(H,21,22)/t5-,7+,8+,9+,10+,11+,13+,14-/m0/s1
type: Species
initial amount: NaN
has only substance units: false

metaR ADRNCPT1
notes: GENE_ASSOCIATION: (1375.1) or (1375.3) or (1375.4) or (126129.1) or (1374.1) or (1375.2) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.21 Confidence Level: 4 AUTHORS: NOTES:NJ
name: carnitine O-palmitoyltransferase
is described by: ECO:0000000
product: MODEL1310110042#
is version of: http://identifiers.org/ec-code/2.3.1.21
modifier: MODEL1310110042#
reactant: MODEL1310110042#
kinetic law: MODEL1310110042#
reversible: false
fast: false
type: Reaction
is: SBO:0000176

metaR r0355
kinetic law: MODEL1310110042#
name: Glycolysis / Glyconeogenesis EC:2.7.1.1
notes: GENE_ASSOCIATION: (AA278423.1) or (48.1) or (50.1) SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: 2.7.1.1 Confidence Level: 0 AUTHORS: PMID:16906315,PMID:7061426,PMID:7150652,PMID:8717435 NOTES:
is: SBO:0000176
type: Reaction
reactant: MODEL1310110042#
is described by: ECO:0000000
modifier: MODEL1310110042#
fast: false
is version of: http://identifiers.org/ec-code/4.2.1.3
product: MODEL1310110042#
reversible: false

metaR EX pectingchol LPAREN e RPAREN
kinetic law: MODEL1310110042#
reactant: MODEL1310110042#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for pectin-glycocholate complex
type: Reaction

metaM hs deg10 l
initial amount: NaN
notes: FORMULA: C55H80N3O70S8 CHARGE: -9
boundary condition: false
has only substance units: false
name: heparan sulfate, degradation product 10
type: Species
is: CHEBI:15748
is: SBO:0000247
initial concentration: 1.0
is: HMDB00127
constant: false

metaM dcholcoa c
type: Species
is: CHEBI:28701
notes: FORMULA: C45H70N7O19P3S CHARGE: -4 INCHI: InChI=1S/C45H74N7O19P3S/c1-24(27-7-8-28-34-29(11-14-45(27,28)5)44(4)13-10-26(53)18-25(44)19-30(34)54)6-9-33(56)75-17-16-47-32(55)12-15-48-41(59)38(58)43(2,3)21-68-74(65,66)71-73(63,64)67-20-31-37(70-72(60,61)62)36(57)42(69-31)52-23-51-35-39(46)49-22-50-40(35)52/h22-31,34,36-38,42,53-54,57-58H,6-21H2,1-5H3,(H,47,55)(H,48,59)(H,63,64)(H,65,66)(H2,46,49,50)(H2,60,61,62)/t24-,25+,26-,27-,28+,29+,30-,31-,34+,36-,37-,38+,42-,44+,45-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01426 EHMN_ABBREVIATION: C05337
initial amount: NaN
initial concentration: 1.0
is: HMDB06292
has only substance units: false
is: SBO:0000247
name: chenodeoxycholoyl coenzyme a
constant: false
boundary condition: false

metaR THRASNNaEx
reversible: false
notes: GENE_ASSOCIATION: (6510.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14530974 NOTES:SAB see Kanai and Hediger 2004 (2003), PMID 14530974
is: SBO:0000185
reactant: MODEL1310110042#
kinetic law: MODEL1310110042#
is described by: ECO:0000269
fast: false
product: MODEL1310110042#
type: Reaction
modifier: MODEL1310110042#
name: L-threonine/L-asparagine Na-dependent exchange (Thr-L in)

metaR r0002
name: Active transport
is described by: ECO:0000000
reactant: MODEL1310110042#
is: SBO:0000185
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:10460205,PMID:1296165,PMID:16288981,PMID:17466261,PMID:2199597,PMID:6219439,PMID:6361812,PMID:8353366 NOTES:
kinetic law: MODEL1310110042#
product: MODEL1310110042#
type: Reaction
reversible: true

metaM chsterol c
is: SBO:0000247
notes: FORMULA: C27H46O CHARGE: 0 INCHI: InChI=1S/C27H46O/c1-18(2)7-6-8-19(3)23-11-12-24-22-10-9-20-17-21(28)13-15-26(20,4)25(22)14-16-27(23,24)5/h9,18-19,21-25,28H,6-8,10-17H2,1-5H3/t19-,21+,22+,23-,24+,25+,26+,27-/m1/s1
boundary condition: false
type: Species
has only substance units: false
is: CHEBI:16113
initial concentration: 1.0
constant: false
name: cholesterol
initial amount: NaN
is: HMDB00067

metaR GLCNACT L
notes: GENE_ASSOCIATION: SUBSYSTEM: N-glycan synthesis EC Number: 2.4.1.141 Confidence Level: 0 AUTHORS: NOTES:
is described by: ECO:0000000
name: UDP-GlcNAc:N-acetyl-D-glucosaminyl diphosphodolichol N-acetyl-D-glucosaminyltransferase (liver)
reactant: MODEL1310110042#
reversible: false
fast: false
kinetic law: MODEL1310110042#
is: SBO:0000176
type: Reaction
product: MODEL1310110042#

metaR TXA2tr
product: MODEL1310110042#
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: NOTES:unknown mechanism for transport - known to be secreted from cells - unknown mechanism or pathway, TXA2tr -> TXA2te to get to EC space NJ
type: Reaction
is described by: ECO:0000000
name: thromboxane A2 intracellular transport
reactant: MODEL1310110042#
is: SBO:0000185
fast: false
kinetic law: MODEL1310110042#

metaR r0668
is described by: ECO:0000000
name: CTP:N-acylneuraminate cytidylyltransferase Aminosugars metabolism EC:2.7.7.43
reactant: MODEL1310110042#
notes: GENE_ASSOCIATION: (AI539321.1) or (23475.1) SUBSYSTEM: Unassigned EC Number: 2.7.7.43 Confidence Level: 0 AUTHORS: PMID:1577759,PMID:422125,PMID:4288894,PMID:4803836,PMID:9689047 NOTES:
kinetic law: MODEL1310110042#
is: SBO:0000176
modifier: MODEL1310110042#
product: MODEL1310110042#
is version of: http://identifiers.org/ec-code/2.4.2.19
type: Reaction
fast: false
reversible: true

metaM ksii core2 pre2 g
has only substance units: false
is: SBO:0000247
is: HMDB00175
name: keratan sulfate II biosynthesis, precursor 2
initial concentration: 1.0
boundary condition: false
type: Species
is: C00130
is: CHEBI:58053
constant: false
initial amount: NaN
notes: FORMULA: C39H63N3O28X CHARGE: -1

metaM chito2pdol L c
initial amount: NaN
type: Species
has only substance units: false
name: N,N'-Diacetylchitobiosyldiphosphodolichol, human liver homolog
constant: false
notes: FORMULA: C1240H2028N20O170P20 CHARGE: -20 INCHI: InChI=1S/C41H72N2O17P2/c1-25(2)13-9-14-26(3)15-10-16-27(4)17-11-18-28(5)19-12-20-29(6)21-22-55-61(51,52)60-62(53,54)59-41-35(43-31(8)47)38(50)39(33(24-45)57-41)58-40-34(42-30(7)46)37(49)36(48)32(23-44)56-40/h13,15,17,19,29,32-41,44-45,48-50H,9-12,14,16,18,20-24H2,1-8H3,(H,42,46)(H,43,47)(H,51,52)(H,53,54)/b26-15+,27-17+,28-19-/t29?,32-,33-,34-,35-,36-,37-,38-,39-,40+,41-/m1/s1
is: HMDB01196
boundary condition: false
initial concentration: 1.0
is: SBO:0000247
is: CHEBI:12427

metaM utp e
is: HMDB00285
has only substance units: false
notes: FORMULA: C9H11N2O15P3 CHARGE: -4 INCHI: InChI=1S/C9H15N2O15P3/c12-5-1-2-11(9(15)10-5)8-7(14)6(13)4(24-8)3-23-28(19,20)26-29(21,22)25-27(16,17)18/h1-2,4,6-8,13-14H,3H2,(H,19,20)(H,21,22)(H,10,12,15)(H2,16,17,18)/p-4/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00077 EHMN_ABBREVIATION: C00075
name: UTP(4-)
type: Species
initial amount: NaN
initial concentration: 1.0
boundary condition: false
is: CHEBI:46398
constant: false
is: SBO:0000247

metaR FACOAL1821
reactant: MODEL1310110042#
is version of: http://identifiers.org/ec-code/6.2.1.3
reversible: true
notes: GENE_ASSOCIATION: (2180.1) SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 4 AUTHORS: PMID:15292367 NOTES:NJ, RE1514C
is described by: ECO:0000269
name: fatty-acid--CoA ligase
fast: false
product: MODEL1310110042#
is: SBO:0000176
type: Reaction
modifier: MODEL1310110042#
kinetic law: MODEL1310110042#

metaR r0354
type: Reaction
fast: false
reversible: false
kinetic law: MODEL1310110042#
modifier: MODEL1310110042#
is version of: http://identifiers.org/ec-code/6.2.1.3
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (AA788780.1) or (AA977580.1) or (2180.1) or (2181.1) or (2182.1) or (51703.1) or (23305.1) or (AI694761.1) or (AI915649.1) or (AL525798.1) or (AV727634.1) or (728637.1) or (LOC728997.1) or (11001.1) SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: 2.7.1.1 Confidence Level: 0 AUTHORS: PMID:16906315,PMID:7061426,PMID:7150652,PMID:8717435 NOTES:
reactant: MODEL1310110042#
name: Glycolysis / Glyconeogenesis EC:2.7.1.1
is: SBO:0000176
product: MODEL1310110042#

metaM for e
type: Species
notes: FORMULA: CH1O2 CHARGE: -1 INCHI: InChI=1S/CH2O2/c2-1-3/h1H,(H,2,3)/p-1 HEPATONET_1.0_ABBREVIATION: HC00061 EHMN_ABBREVIATION: C00058
is: HMDB00142
name: formate
initial amount: NaN
constant: false
initial concentration: 1.0
is: CHEBI:15740
has only substance units: false
is: SBO:0000247
boundary condition: false

metaR S4TASE2ly
type: Reaction
name: N-acetylgalactosamine-4-sulfatase, lysosomal
is described by: ECO:0000000
product: MODEL1310110042#
is: SBO:0000176
fast: false
notes: GENE_ASSOCIATION: (411.2) or (411.1) SUBSYSTEM: Chondroitin sulfate degradation EC Number: 3.1.6.12 Confidence Level: 4 AUTHORS: PMID:1968043,PMID:2303452 NOTES:NCD
is version of: http://identifiers.org/ec-code/3.1.6.12
reversible: true
kinetic law: MODEL1310110042#
reactant: MODEL1310110042#
modifier: MODEL1310110042#

metaM nadh c
constant: false
is: C00004
name: Nicotinamide adenine dinucleotide - reduced
boundary condition: false
initial amount: NaN
is: CHEBI:57945
has only substance units: false
type: Species
is: SBO:0000247
initial concentration: 1.0
is: http://identifiers.org/pubchem.compound/3306
is: HMDB01487

metaR SO4tl
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 1 AUTHORS: PMID:10535998,PMID:15607730 NOTES:
reactant: MODEL1310110042#
product: MODEL1310110042#
fast: false
type: Reaction
kinetic law: MODEL1310110042#
is described by: ECO:0000269
reversible: true
name: Sulfate transport (lysosome)
is: SBO:0000185

metaM cbasp c
name: N-Carbamoyl-L-aspartate
notes: FORMULA: C5H6N2O5 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00356 EHMN_ABBREVIATION: C00438
is: SBO:0000247
has only substance units: false
is: HMDB00828
type: Species
boundary condition: false
is: C00438
initial concentration: 1.0
is: CHEBI:32814
initial amount: NaN
constant: false

metaR SMS
fast: false
reversible: false
product: MODEL1310110042#
is: SBO:0000176
modifier: MODEL1310110042#
is described by: ECO:0000269
type: Reaction
kinetic law: MODEL1310110042#
reactant: MODEL1310110042#
is version of: http://identifiers.org/ec-code/2.7.8.27
notes: GENE_ASSOCIATION: (259230.1) SUBSYSTEM: Sphingolipid metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:14685263 NOTES:NJ
name: Sphingomyelin synthase (homo sapiens)

metaM gchola c
notes: FORMULA: C26H43NO6 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00863 EHMN_ABBREVIATION: C01921
is: HMDB00138
is: SBO:0000247
initial amount: NaN
name: glycocholate
boundary condition: false
initial concentration: 1.0
constant: false
has only substance units: false
is: CHEBI:58235
type: Species

http://identifiers.org/biomodels.db/MODEL1310110042#_beda00d5_431f_4966_b6c9_308737f0e124
boundary condition: true
has only substance units: false
is: P33261
initial amount: NaN
name: CYP2C19
type: Species
is encoded by: hsa:1557
is: SBO:0000252
initial concentration: NaN
constant: false

http://identifiers.org/biomodels.db/MODEL1310110042#_8b08b52f_34a5_4121_bb60_08f6b58af919
initial amount: NaN
is encoded by: hsa:1345
initial concentration: NaN
type: Species
name: COX6C
constant: false
boundary condition: true
has only substance units: false
is: P09669
is: SBO:0000252

metaM ump n
initial amount: NaN
is: HMDB00288
initial concentration: 1.0
name: UMP(2-)
notes: FORMULA: C9H11N2O9P CHARGE: -2 INCHI: InChI=1S/C9H13N2O9P/c12-5-1-2-11(9(15)10-5)8-7(14)6(13)4(20-8)3-19-21(16,17)18/h1-2,4,6-8,13-14H,3H2,(H,10,12,15)(H2,16,17,18)/p-2/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00105 EHMN_ABBREVIATION: C00105
boundary condition: false
type: Species
is: CHEBI:57865
has only substance units: false
is: SBO:0000247
constant: false

metaM nadp m
constant: false
notes: FORMULA: C21H25N7O17P3 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00016 EHMN_ABBREVIATION: C00006
initial concentration: 1.0
is: HMDB00217
type: Species
boundary condition: false
is: C00006
name: Nicotinamide adenine dinucleotide phosphate
is: CHEBI:58349
has only substance units: false
is: SBO:0000247
initial amount: NaN

metaM sbcoa x
has only substance units: false
notes: FORMULA: C29H43N7O19P3S CHARGE: -5
initial amount: NaN
initial concentration: 1.0
boundary condition: false
constant: false
is: SBO:0000247
name: suberylcoa
type: Species
is: http://identifiers.org/pubchem.compound/16019966

metaM lnlncgcoa x
is: CHEBI:57363
notes: FORMULA: C39H60N7O17P3S CHARGE: -4 INCHI: InChI=1S/C39H64N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-30(48)67-23-22-41-29(47)20-21-42-37(51)34(50)39(2,3)25-60-66(57,58)63-65(55,56)59-24-28-33(62-64(52,53)54)32(49)38(61-28)46-27-45-31-35(40)43-26-44-36(31)46/h8-9,11-12,14-15,26-28,32-34,38,49-50H,4-7,10,13,16-25H2,1-3H3,(H,41,47)(H,42,51)(H,55,56)(H,57,58)(H2,40,43,44)(H2,52,53,54)/p-4/b9-8-,12-11-,15-14-/t28-,32-,33-,34+,38-/m1/s1 EHMN_ABBREVIATION: C03035
initial concentration: 1.0
initial amount: NaN
name: gamma-linolenoyl-CoA(4-)
constant: false
is: SBO:0000247
is: HMDB06368
type: Species
boundary condition: false
has only substance units: false

metaR BAAT3x
reversible: false
kinetic law: MODEL1310110042#
product: MODEL1310110042#
notes: GENE_ASSOCIATION: (570.1) SUBSYSTEM: Bile acid synthesis EC Number: 2.3.1.65 Confidence Level: 2 AUTHORS: NOTES:third version analog added as per KEGG NJ
modifier: MODEL1310110042#
is version of: http://identifiers.org/ec-code/2.3.1.65
fast: false
is described by: ECO:0000304
is: SBO:0000176
name: bile acid Coenzyme A: amino acid N-acyltransferase
type: Reaction
reactant: MODEL1310110042#

metaR EX mal L LPAREN e RPAREN
kinetic law: MODEL1310110042#
reactant: MODEL1310110042#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: Exchange of L-malate
type: Reaction

metaR EX HC02204 LPAREN e RPAREN
kinetic law: MODEL1310110042#
reactant: MODEL1310110042#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: prostaglandin-b1 exchange
type: Reaction

metaM apnnox e
boundary condition: false
constant: false
is: HMDB03667
initial amount: NaN
initial concentration: 1.0
type: Species
notes: FORMULA: C10H16O CHARGE: 0 INCHI: InChI=1S/C10H16O/c1-9(2)6-4-7(9)10(3)8(5-6)11-10/h6-8H,4-5H2,1-3H3
is: SBO:0000247
is: CHEBI:29060
name: alpha-pinene oxide
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110042#_8f82371f_9928_4e35_ba1a_3511064b0a66
is: O95864
is encoded by: hsa:9415
constant: false
type: Species
initial amount: NaN
initial concentration: NaN
has only substance units: false
is: SBO:0000252
name: FADS2
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110042#_b0a60e03_6fcf_4418_868f_7e44975d23a1
is: Q15067
initial amount: NaN
name: ACOX1
is encoded by: hsa:51
has only substance units: false
boundary condition: true
type: Species
is: SBO:0000252
constant: false
initial concentration: NaN

metaM chsterol e
has only substance units: false
is: HMDB00067
is: CHEBI:16113
is: SBO:0000247
initial concentration: 1.0
name: cholesterol
type: Species
initial amount: NaN
constant: false
boundary condition: false
notes: FORMULA: C27H46O CHARGE: 0 INCHI: InChI=1S/C27H46O/c1-18(2)7-6-8-19(3)23-11-12-24-22-10-9-20-17-21(28)13-15-26(20,4)25(22)14-16-27(23,24)5/h9,18-19,21-25,28H,6-8,10-17H2,1-5H3/t19-,21+,22+,23-,24+,25+,26+,27-/m1/s1

http://identifiers.org/biomodels.db/MODEL1310110042#_88c45ce6_0886_4974_a469_46bde70e2e3c
type: Species
has part: P48728
has part: P23378
is encoded by: hsa:2653
name: DLD:GCSH:GLDC:AMT
is encoded by: hsa:2731
is: SBO:0000297
constant: false
initial concentration: NaN
boundary condition: true
initial amount: NaN
has only substance units: false
has part: P23434
is encoded by: hsa:275

metaR LEUtec
modifier: MODEL1310110042#
reversible: true
is described by: ECO:0000269
kinetic law: MODEL1310110042#
type: Reaction
fast: false
is: SBO:0000185
notes: GENE_ASSOCIATION: (8501.1) or (124935.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12930836,PMID:14624363,PMID:15659399 NOTES:SAB
name: L-leucine transport via diffusion (extracellular to cytosol)
product: MODEL1310110042#
reactant: MODEL1310110042#

metaM arachdcrn m
constant: false
initial concentration: 1.0
has only substance units: false
notes: FORMULA: C27H45NO4 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC12236
is: CHEBI:57387
boundary condition: false
is: SBO:0000247
is: HMDB01322
type: Species
initial amount: NaN
name: C20:4 carnitine

metaR SERGLYexR
reversible: true
type: Reaction
notes: GENE_ASSOCIATION: (56301.1) and (6520.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10734121,PMID:10863037,PMID:14770310 NOTES:
product: MODEL1310110042#
is described by: ECO:0000304
is: SBO:0000185
kinetic law: MODEL1310110042#
fast: false
name: L-Serine/Glycine reversible exchange
modifier: MODEL1310110042#
reactant: MODEL1310110042#

http://identifiers.org/biomodels.db/MODEL1310110042#_46138b32_3c88_44ae_a14d_c37aa54548d7
has only substance units: false
is: SBO:0000252
initial concentration: NaN
is: Q15392
name: DHCR24
type: Species
constant: false
initial amount: NaN
boundary condition: true
is encoded by: hsa:1718

metaR r0666
kinetic law: MODEL1310110042#
is described by: ECO:0000000
modifier: MODEL1310110042#
reactant: MODEL1310110042#
product: MODEL1310110042#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.2.4.2
notes: GENE_ASSOCIATION: (4967.1) or (55753.1) SUBSYSTEM: Purine synthesis EC Number: 6.3.3.1 Confidence Level: 0 AUTHORS: PMID:4084560 NOTES:
reversible: true
name: 2-(Formamido)-N1-(5-phosphoribosyl)acetamidine cyclo-ligase (ADP-forming) Purine metabolism EC:6.3.3.1
fast: false
type: Reaction

metaR r2079
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
reversible: true
kinetic law: MODEL1310110042#
modifier: MODEL1310110042#
is described by: ECO:0000000
type: Reaction
product: MODEL1310110042#
reactant: MODEL1310110042#
fast: false
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110042#_af8a3faa_720b_4341_bbfd_80859f5f9396
initial concentration: NaN
boundary condition: true
is encoded by: hsa:498
is: A8K092
has only substance units: false
constant: false
type: Species
is: SBO:0000252
name: ATP5A1
initial amount: NaN

metaM for c
is: SBO:0000247
type: Species
notes: FORMULA: CH1O2 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00061 EHMN_ABBREVIATION: C00058
is: HMDB00142
initial amount: NaN
initial concentration: 1.0
constant: false
is: CHEBI:15740
is: C00058
has only substance units: false
boundary condition: false
name: Formate

metaM ocdcea r
has only substance units: false
initial amount: NaN
notes: FORMULA: C18H33O2 CHARGE: -1
type: Species
is: C00712
is: HMDB00207
is: SBO:0000247
constant: false
boundary condition: false
name: octadecenoate (n-C18:1)
is: CHEBI:0
initial concentration: 1.0

metaR FAOXC227C226m
kinetic law: MODEL1310110042#
product: MODEL1310110042#
reactant: MODEL1310110042#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C22:7-->C22:6)m
type: Reaction

metaR GLCNACASE5ly
is: SBO:0000176
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/3.2.1.50
name: alpha-N-acetylglucosaminidase, lysosomal
product: MODEL1310110042#
kinetic law: MODEL1310110042#
modifier: MODEL1310110042#
reversible: false
reactant: MODEL1310110042#
type: Reaction
fast: false
notes: GENE_ASSOCIATION: (4669.1) SUBSYSTEM: Heparan sulfate degradation EC Number: 3.2.1.50 Confidence Level: 4 AUTHORS: PMID:1783617,PMID:8776591,PMID:8993162 NOTES:NCD

http://identifiers.org/biomodels.db/MODEL1310110042#_ed6fedc0_62a2_48b2_9f67_f917e4a925cd
type: Species
has only substance units: false
boundary condition: true
initial concentration: NaN
initial amount: NaN
name: ABCB4
is: SBO:0000252
constant: false
is encoded by: hsa:5244

metaM gchola e
constant: false
is: HMDB00138
boundary condition: false
name: glycocholate
initial amount: NaN
type: Species
is: SBO:0000247
has only substance units: false
notes: FORMULA: C26H43NO6 CHARGE: 0
initial concentration: 1.0

metaM hpdcacoa c
boundary condition: false
constant: false
notes: FORMULA: C38H64N7O17P3S CHARGE: -4 INCHI: InChI=1/C38H68N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-29(47)66-22-21-40-28(46)19-20-41-36(50)33(49)38(2,3)24-59-65(56,57)62-64(54,55)58-23-27-32(61-63(51,52)53)31(48)37(60-27)45-26-44-30-34(39)42-25-43-35(30)45/h25-27,31-33,37,48-49H,4-24H2,1-3H3,(H,40,46)(H,41,50)(H,54,55)(H,56,57)(H2,39,42,43)(H2,51,52,53)/t27-,31-,32-,33+,37-/m1/s1
initial concentration: 1.0
is: HMDB06497
type: Species
name: heptadecanoyl coa
has only substance units: false
initial amount: NaN
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110042#_c30518c9_867e_4f3d_a4f2_0a64c9585c39
has only substance units: false
is encoded by: hsa:6487
name: ST3GAL3
initial concentration: NaN
is: SBO:0000252
type: Species
constant: false
boundary condition: true
initial amount: NaN

metaR EX dgtp LPAREN e RPAREN
kinetic law: MODEL1310110042#
reactant: MODEL1310110042#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of dGTP
type: Reaction

metaR PEROXx
is version of: http://identifiers.org/ec-code/2.3.1.16
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/1.3.3.6
name: peroxisomal lumped long chain fatty acid oxidation
product: MODEL1310110042#
reversible: false
is: SBO:0000176
kinetic law: MODEL1310110042#
fast: false
modifier: MODEL1310110042#
is version of: http://identifiers.org/ec-code/4.2.1.107
is version of: http://identifiers.org/ec-code/1.1.1.35
notes: GENE_ASSOCIATION: (3295.1 and 8310.1 and 30.1 and 1962.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: PMID:11591435,PMID:12814641,PMID:15599942,PMID:1679347,PMID:7487879,PMID:8188243 NOTES:lumped peroxisomal alpha and beta oxidation pristanoyl-CoA -> 4,8 diemthylnonanoyl-CoA (result of compound not known) stoichiometry for O2 is questionable at present no fad in peroxisome - 1st step of beta ox is acyl-co oxidase (not reductase) NJ
type: Reaction
reactant: MODEL1310110042#

metaR C16DCe
kinetic law: MODEL1310110042#
product: MODEL1310110042#
reactant: MODEL1310110042#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of Hexadecanedioic acid mono-L-carnitine ester into extra cellular space
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110042#_be32a487_08d5_4bb5_8ad1_afcab08faca9
initial amount: NaN
type: Species
is: Q99714
is: SBO:0000252
has only substance units: false
name: HSD17B10
is encoded by: hsa:3028
initial concentration: NaN
constant: false
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110042#_6605036a_35c0_4d70_adc9_1c86a776494f
initial concentration: NaN
has only substance units: false
boundary condition: true
constant: false
name: DGKA
is: P23743
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:1606
type: Species

http://identifiers.org/biomodels.db/MODEL1310110042#_e9cbd6a0_011e_40a9_9cfd_f451e234bd98
type: Species
boundary condition: true
name: VNN3
constant: false
is encoded by: hsa:55350
is: SBO:0000252
initial concentration: NaN
initial amount: NaN
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110042#_76d3efee_3322_4226_8536_0f8b8c9a075c
is: D9HTE9
boundary condition: true
initial amount: NaN
type: Species
is encoded by: hsa:6576
has only substance units: false
is: SBO:0000252
constant: false
initial concentration: NaN
name: SLC25A1

metaM apnnox c
constant: false
initial concentration: 1.0
has only substance units: false
is: SBO:0000247
boundary condition: false
type: Species
is: HMDB03667
initial amount: NaN
name: alpha-pinene oxide
is: CHEBI:29060
notes: FORMULA: C10H16O CHARGE: 0 INCHI: InChI=1S/C10H16O/c1-9(2)6-4-7(9)10(3)8(5-6)11-10/h6-8H,4-5H2,1-3H3

metaR FAOXC12DCc
kinetic law: MODEL1310110042#
product: MODEL1310110042#
reactant: MODEL1310110042#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: formation of dodecanedioyl carnitine
type: Reaction

metaM pre prot r
is: SBO:0000247
type: Species
constant: false
is: CHEBI:16240
boundary condition: false
notes: FORMULA: XY CHARGE: 0
has only substance units: false
name: glycophosphatidylinositol (GPI)-anchored protein precursor
is: HMDB03125
initial concentration: 1.0
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110042#_d78dbd62_7b90_460d_9d86_6196dcfe0b96
is: SBO:0000252
type: Species
constant: false
is encoded by: hsa:6647
boundary condition: true
initial concentration: NaN
has only substance units: false
is: P00441
name: SOD1
initial amount: NaN

metaM xoltetrol m
has only substance units: false
initial concentration: 1.0
constant: false
notes: FORMULA: C27H48O4 CHARGE: 0 INCHI: InChI=1S/C27H48O4/c1-16(15-28)6-5-7-17(2)20-8-9-21-25-22(14-24(31)27(20,21)4)26(3)11-10-19(29)12-18(26)13-23(25)30/h16-25,28-31H,5-15H2,1-4H3/t16?,17-,18+,19-,20-,21+,22+,23-,24+,25+,26+,27-/m1/s1 EHMN_ABBREVIATION: C05446
initial amount: NaN
is: HMDB01231
is: CHEBI:17278
is: SBO:0000247
type: Species
boundary condition: false
name: 5beta-cholestane-3alpha,7alpha,12alpha,26-tetrol

metaM nadp r
is: HMDB00217
has only substance units: false
initial concentration: 1.0
initial amount: NaN
is: CHEBI:58349
is: SBO:0000247
boundary condition: false
notes: FORMULA: C21H25N7O17P3 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00016 EHMN_ABBREVIATION: C00006
constant: false
is: C00006
name: Nicotinamide adenine dinucleotide phosphate
type: Species

metaR r1725
reversible: false
modifier: MODEL1310110042#
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
fast: false
is: SBO:0000185
is described by: ECO:0000000
name: Y+LAT2 Utilized transport
product: MODEL1310110042#
type: Reaction
reactant: MODEL1310110042#
kinetic law: MODEL1310110042#

metaR CLPNDCOAtx
is described by: ECO:0000000
kinetic law: MODEL1310110042#
fast: false
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: NOTES:interaction between peroxisomes and ER (some enzymes on the outer membrane) NJ
is: SBO:0000185
name: fatty acid intracellular transport
product: MODEL1310110042#
reversible: true
reactant: MODEL1310110042#

metaR PMTCOAtx
is described by: ECO:0000000
product: MODEL1310110042#
type: Reaction
is: SBO:0000185
name: fatty acid intracellular transport
reactant: MODEL1310110042#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: NOTES:interaction between peroxisomes and ER (some enzymes on the outer membrane) NJ
kinetic law: MODEL1310110042#
reversible: true
fast: false

metaR SIAASEly
kinetic law: MODEL1310110042#
is version of: http://identifiers.org/ec-code/3.2.1.23
modifier: MODEL1310110042#
is: SBO:0000176
reversible: false
is version of: http://identifiers.org/ec-code/3.4.16.5
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) SUBSYSTEM: N-glycan degradation EC Number: 3.2.1.18 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD
product: MODEL1310110042#
fast: false
name: sialidase, lysosomal
reactant: MODEL1310110042#
is version of: http://identifiers.org/ec-code/3.2.1.18
is described by: ECO:0000000
type: Reaction
is version of: http://identifiers.org/ec-code/3.1.6.4

metaR LCYSTAT
reactant: MODEL1310110042#
product: MODEL1310110042#
kinetic law: MODEL1310110042#
is described by: ECO:0000304
is version of: http://identifiers.org/ec-code/2.6.1.1
fast: false
reversible: true
name: L-Cysteate:2-oxoglutarate aminotransferase
notes: GENE_ASSOCIATION: (2805.1) SUBSYSTEM: Methionine and cysteine metabolism EC Number: 2.6.1.1 Confidence Level: 2 AUTHORS: PMID:3346220 NOTES:described in PMID: 3346220 and KEGG MM
is: SBO:0000176
type: Reaction
modifier: MODEL1310110042#

metaM lnlc c
initial amount: NaN
has only substance units: false
constant: false
is: HMDB00673
notes: FORMULA: C18H31O2 CHARGE: -1 INCHI: InChI=1S/C18H32O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20/h6-7,9-10H,2-5,8,11-17H2,1H3,(H,19,20)/p-1/b7-6-,10-9-
name: linoleate
is: CHEBI:30245
is: SBO:0000247
type: Species
boundary condition: false
initial concentration: 1.0

metaM c16dc c
notes: FORMULA: C23H42NO6 CHARGE: -1
is: HMDB00712
name: Hexadecanedioic acid mono-L-carnitine ester
is: SBO:0000247
initial concentration: 1.0
has only substance units: false
initial amount: NaN
boundary condition: false
constant: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110042#_eddc09fe_d2d4_4865_8cf0_bcb2b59a2336
has only substance units: false
boundary condition: true
name: CA8
type: Species
initial amount: NaN
initial concentration: NaN
constant: false
is: P35219
is encoded by: hsa:767
is: SBO:0000252

metaM thcholstoic x
initial concentration: 1.0
type: Species
is: HMDB03873
name: 3alpha,7alpha,12alpha-Trihydroxy-5beta-cholestanoate
is: CHEBI:18402
initial amount: NaN
boundary condition: false
notes: FORMULA: C27H45O5 CHARGE: -1 INCHI: InChI=1S/C27H46O5/c1-15(6-5-7-16(2)25(31)32)19-8-9-20-24-21(14-23(30)27(19,20)4)26(3)11-10-18(28)12-17(26)13-22(24)29/h15-24,28-30H,5-14H2,1-4H3,(H,31,32)/t15-,16?,17+,18-,19-,20+,21+,22-,23+,24+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01340 EHMN_ABBREVIATION: C04722
constant: false
is: SBO:0000247
has only substance units: false

metaM 3mox4hoxm c
boundary condition: false
is: HMDB00291
constant: false
is: SBO:0000247
notes: FORMULA: C9H9O5 CHARGE: -1 INCHI: InChI=1S/C9H10O5/c1-14-7-4-5(2-3-6(7)10)8(11)9(12)13/h2-4,8,10-11H,1H3,(H,12,13)/p-1 HEPATONET_1.0_ABBREVIATION: HC01521 EHMN_ABBREVIATION: C05584
has only substance units: false
is: CHEBI:27622
initial concentration: 1.0
type: Species
name: 3-Methoxy-4-hydroxymandelate
initial amount: NaN

metaR LNSTLSr
modifier: MODEL1310110042#
reversible: false
reactant: MODEL1310110042#
fast: false
type: Reaction
kinetic law: MODEL1310110042#
name: lanosterol synthase
is described by: ECO:0000134
is version of: http://identifiers.org/ec-code/5.4.99.7
product: MODEL1310110042#
is: SBO:0000176
notes: GENE_ASSOCIATION: (4047.1) SUBSYSTEM: Cholesterol metabolism EC Number: 5.4.99.7 Confidence Level: 2 AUTHORS: PMID:17925399,PMID:17925400,PMID:18830876,PMID:18830877 NOTES:NCD ER version - NJ

metaR CAt7r
is: SBO:0000185
modifier: MODEL1310110042#
fast: false
kinetic law: MODEL1310110042#
product: MODEL1310110042#
type: Reaction
name: calcium / sodium antiporter (1:3), reversible
reversible: true
is described by: ECO:0000269
reactant: MODEL1310110042#
notes: GENE_ASSOCIATION: (6547.6) or (6547.4) or (6547.2) or (6546.1) or (6547.1) or (6547.5) or (6543.1) or (6547.3) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12406570,PMID:2484986 NOTES:MM

metaR EX prostgd2 LPAREN e RPAREN
kinetic law: MODEL1310110042#
reactant: MODEL1310110042#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Prostaglandin D2 exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110042#_4dfb74d1_1e49_41ed_8bfa_2e397ba1ca5d
boundary condition: true
constant: false
type: Species
is: P00390
has only substance units: false
initial amount: NaN
is: SBO:0000252
initial concentration: NaN
name: GSR
is encoded by: hsa:2936

metaM 4pyrdx e
initial amount: NaN
is: SBO:0000247
initial concentration: 1.0
is: CHEBI:30959
is: HMDB00017
notes: FORMULA: C8H9NO4 CHARGE: 0 INCHI: InChI=1S/C8H9NO4/c1-4-7(11)6(8(12)13)5(3-10)2-9-4/h2,10-11H,3H2,1H3,(H,12,13)/p-1 EHMN_ABBREVIATION: C00847
name: 4-pyridoxate
boundary condition: false
has only substance units: false
type: Species
constant: false

metaR r0892
reactant: MODEL1310110042#
kinetic law: MODEL1310110042#
is version of: http://identifiers.org/ec-code/3.1.2.27
fast: false
is: SBO:0000185
type: Reaction
reversible: true
product: MODEL1310110042#
name: Facilitated diffusion
notes: GENE_ASSOCIATION: (10005.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:179827,PMID:9305892 NOTES:
is described by: ECO:0000000
modifier: MODEL1310110042#

http://identifiers.org/biomodels.db/MODEL1310110042#_3779843c_2cab_468a_b7df_ee21f3471414
initial amount: NaN
is: Q5HYI4
has only substance units: false
is encoded by: hsa:6713
constant: false
is: SBO:0000252
name: SQLE
type: Species
boundary condition: true
initial concentration: NaN

metaR DHCR71r
product: MODEL1310110042#
notes: GENE_ASSOCIATION: (1717.1) SUBSYSTEM: Cholesterol metabolism EC Number: 1.3.1.21 Confidence Level: 4 AUTHORS: PMID:9465114 NOTES:lanosterol -> cholesterol pathway see paper refs Moebius et al PNAS 95:1899-1902 - check/re-check lit for more specific details (NADPH known to be cofactor - also NADH?, possibly rev?) NJ
is version of: http://identifiers.org/ec-code/1.3.1.21
is: SBO:0000176
kinetic law: MODEL1310110042#
type: Reaction
reversible: false
fast: false
reactant: MODEL1310110042#
modifier: MODEL1310110042#
is described by: ECO:0000134
name: 7-dehydrocholesterol reductase

metaR ACOX22x
is: SBO:0000176
product: MODEL1310110042#
fast: false
is described by: ECO:0000304
reversible: false
kinetic law: MODEL1310110042#
notes: GENE_ASSOCIATION: (8309.1) SUBSYSTEM: Bile acid synthesis EC Number: 1.3.3.6 Confidence Level: 2 AUTHORS: PMID:11181649 NOTES:noted in uniprot to have FAD as cofactor - further reaction specific lit evidence not found to support or contradict, see Baumgart et al PNAS (1996) 93: 13748-13753 analog as per KEGG added NJ
reactant: MODEL1310110042#
modifier: MODEL1310110042#
is version of: http://identifiers.org/ec-code/1.17.99.3
type: Reaction
name: acyl-Coenzyme A oxidase 2, branched chain

metaM cbasp e
initial concentration: 1.0
notes: FORMULA: C5H6N2O5 CHARGE: -2
constant: false
is: C00438
has only substance units: false
boundary condition: false
is: HMDB00828
name: N-Carbamoyl-L-aspartate
initial amount: NaN
is: SBO:0000247
is: CHEBI:32814
type: Species

http://identifiers.org/biomodels.db/MODEL1310110042#_2f81e1cd_de0a_4f31_88ed_f49a14852b0b
initial concentration: NaN
has only substance units: false
is encoded by: hsa:4722
initial amount: NaN
name: NDUFS3
is: O75489
is: SBO:0000252
boundary condition: true
constant: false
type: Species

metaR FACOAL180i
is: SBO:0000176
product: MODEL1310110042#
name: C180 fatty acid activation
type: Reaction
reactant: MODEL1310110042#
is version of: http://identifiers.org/ec-code/6.2.1.3
modifier: MODEL1310110042#
fast: false
kinetic law: MODEL1310110042#
notes: GENE_ASSOCIATION: (22305.2) or (2181.2) or (51703.1) or (2181.1) or (2180.1) or (22305.1) SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 4 AUTHORS: NOTES:TV catalyzed by acyl-CoA synthetases
is described by: ECO:0000269
reversible: false

metaM c16dc e
boundary condition: false
has only substance units: false
type: Species
initial amount: NaN
initial concentration: 1.0
notes: FORMULA: C23H42NO6 CHARGE: -1
is: SBO:0000247
constant: false
is: HMDB00712
name: Hexadecanedioic acid mono-L-carnitine ester

metaR DPMVDx
is: SBO:0000176
product: MODEL1310110042#
is described by: ECO:0000134
type: Reaction
is version of: http://identifiers.org/ec-code/4.1.1.33
notes: GENE_ASSOCIATION: (4597.1) SUBSYSTEM: Cholesterol metabolism EC Number: 4.1.1.33 Confidence Level: 4 AUTHORS: PMID:8188698 NOTES:peroxisomal version - NJ
modifier: MODEL1310110042#
reversible: false
reactant: MODEL1310110042#
kinetic law: MODEL1310110042#
name: diphosphomevalonate decarboxylase
fast: false

metaR EX bilirub LPAREN e RPAREN
kinetic law: MODEL1310110042#
reactant: MODEL1310110042#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Bilirubin exchange
type: Reaction

metaR NDPK2n
reactant: MODEL1310110042#
product: MODEL1310110042#
is: SBO:0000176
kinetic law: MODEL1310110042#
type: Reaction
is version of: http://identifiers.org/ec-code/2.7.4.6
reversible: true
modifier: MODEL1310110042#
notes: GENE_ASSOCIATION: (4831.1 and 4830.1) or (4830.2 and 4831.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.6 Confidence Level: 4 AUTHORS: NOTES:Many nucleoside diphosphates (eight described) can act as acceptors. While many ribo- and deoxyribonucleoside triphosphates can act as donors, only ATP is chosen as a donor to minimize the number of total reactions.
fast: false
is described by: ECO:0000269
name: nucleoside-diphosphate kinase (ATP:UDP), nuclear

metaR FAOXC141C141OHm
kinetic law: MODEL1310110042#
product: MODEL1310110042#
reactant: MODEL1310110042#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C14:1-->C14:1OH)m
type: Reaction

metaR r0669
fast: false
type: Reaction
is described by: ECO:0000000
kinetic law: MODEL1310110042#
name: (S)-3-Hydroxyisobutyryl-CoA hydro-lyase Valine, leucine and isoleucine degradation EC:4.2.1.17
reactant: MODEL1310110042#
notes: GENE_ASSOCIATION: SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 4.2.1.17 Confidence Level: 0 AUTHORS: PMID:10671535,PMID:12467702 NOTES:
reversible: false
product: MODEL1310110042#
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110042#_28e93b17_a45e_4ac8_a8d2_23edcf075054
is: SBO:0000252
initial concentration: NaN
type: Species
is encoded by: hsa:84264
name: HAGHL
boundary condition: true
constant: false
initial amount: NaN
has only substance units: false

metaR GRTTx
notes: GENE_ASSOCIATION: (2224.1) SUBSYSTEM: Cholesterol metabolism EC Number: 2.5.1.10 Confidence Level: 4 AUTHORS: PMID:8188698 NOTES:peroxisomal version - NJ
is described by: ECO:0000134
is: SBO:0000176
reactant: MODEL1310110042#
product: MODEL1310110042#
kinetic law: MODEL1310110042#
is version of: http://identifiers.org/ec-code/2.5.1.1
modifier: MODEL1310110042#
fast: false
type: Reaction
reversible: false
name: geranyltranstransferase

metaM lnlncgcoa r
initial concentration: 1.0
notes: FORMULA: C39H60N7O17P3S CHARGE: -4 INCHI: InChI=1S/C39H64N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-30(48)67-23-22-41-29(47)20-21-42-37(51)34(50)39(2,3)25-60-66(57,58)63-65(55,56)59-24-28-33(62-64(52,53)54)32(49)38(61-28)46-27-45-31-35(40)43-26-44-36(31)46/h8-9,11-12,14-15,26-28,32-34,38,49-50H,4-7,10,13,16-25H2,1-3H3,(H,41,47)(H,42,51)(H,55,56)(H,57,58)(H2,40,43,44)(H2,52,53,54)/p-4/b9-8-,12-11-,15-14-/t28-,32-,33-,34+,38-/m1/s1 EHMN_ABBREVIATION: C03035
is: CHEBI:57363
name: gamma-linolenoyl-CoA(4-)
is: SBO:0000247
constant: false
type: Species
is: HMDB06368
boundary condition: false
has only substance units: false
initial amount: NaN

metaM ump e
is: CHEBI:57865
name: UMP(2-)
type: Species
initial concentration: 1.0
is: HMDB00288
has only substance units: false
constant: false
boundary condition: false
initial amount: NaN
notes: FORMULA: C9H11N2O9P CHARGE: -2 INCHI: InChI=1S/C9H13N2O9P/c12-5-1-2-11(9(15)10-5)8-7(14)6(13)4(20-8)3-19-21(16,17)18/h1-2,4,6-8,13-14H,3H2,(H,10,12,15)(H2,16,17,18)/p-2/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00105 EHMN_ABBREVIATION: C00105
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110042#_c475778f_6506_4071_8d5c_d80fedc4c256
boundary condition: true
type: Species
initial concentration: NaN
has only substance units: false
constant: false
name: _AU149534_1_m
initial amount: NaN
is: SBO:0000252
is encoded by: hsa:AU149534

http://identifiers.org/biomodels.db/MODEL1310110042#_4ca7d4f5_0add_4fa4_be68_a046bb3de93d
is encoded by: hsa:6185
initial concentration: NaN
boundary condition: true
is: P04844
has only substance units: false
type: Species
constant: false
is: SBO:0000252
name: RPN2
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110042#_1b1f65d6_1de2_4a41_8d06_1f88363c8754
is: SBO:0000252
name: SLC2A13
is encoded by: hsa:114134
type: Species
boundary condition: true
constant: false
initial amount: NaN
is: Q96QE2
has only substance units: false
initial concentration: NaN

metaR FAOXC226205m
kinetic law: MODEL1310110042#
is described by: ECO:0000000
name: Beta oxidation of long chain fatty acid
is: SBO:0000176
fast: false
product: MODEL1310110042#
is version of: http://identifiers.org/ec-code/1.3.8.1
reactant: MODEL1310110042#
is version of: http://identifiers.org/ec-code/1.3.99.3
modifier: MODEL1310110042#
type: Reaction
notes: GENE_ASSOCIATION: (35.1) or (34.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.74 Confidence Level: 4 AUTHORS: PMID:2565344,PMID:3035565 NOTES:_1 round of beta-oxidation, loses degree of desat, so no fad peroxisomal (very long chain FA) c22:6,n-3 -> c20:5, n-3 4 step FAO lumped also includes EC 1.1.1.35, 1.1.1.211, 1.3.3.6, 4.2.1.17, 4.2.1.74 NJ
reversible: false

metaM 4pyrdx c
has only substance units: false
is: SBO:0000247
constant: false
boundary condition: false
type: Species
is: CHEBI:30959
is: HMDB00017
name: 4-pyridoxate
initial amount: NaN
initial concentration: 1.0
notes: FORMULA: C8H9NO4 CHARGE: 0 INCHI: InChI=1S/C8H9NO4/c1-4-7(11)6(8(12)13)5(3-10)2-9-4/h2,10-11H,3H2,1H3,(H,12,13)/p-1 EHMN_ABBREVIATION: C00847

metaR GLYCtm
type: Reaction
reversible: true
fast: false
name: glycerol transport
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: NOTES:TDV
kinetic law: MODEL1310110042#
reactant: MODEL1310110042#
product: MODEL1310110042#
is described by: ECO:0000000

metaR PAFHe
product: MODEL1310110042#
kinetic law: MODEL1310110042#
reversible: false
modifier: MODEL1310110042#
name: Platelet-activating factor acetylhydrolase
reactant: MODEL1310110042#
is version of: http://identifiers.org/ec-code/3.1.1.47
fast: false
is: SBO:0000176
notes: GENE_ASSOCIATION: (7941.1) SUBSYSTEM: Glycerophospholipid metabolism EC Number: 3.1.1.47 Confidence Level: 4 AUTHORS: PMID:8675689 NOTES:NJ
type: Reaction
is described by: ECO:0000269

http://identifiers.org/biomodels.db/MODEL1310110042#_c54284bb_f770_4469_9ed7_70ca8e2d556b
is: P50993
is: SBO:0000252
type: Species
boundary condition: true
has only substance units: false
constant: false
name: ATP1A2
initial concentration: NaN
is encoded by: hsa:477
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110042#_5d514110_e4cf_4238_9903_2d537bcb0d01
type: Species
boundary condition: true
constant: false
initial amount: NaN
has only substance units: false
is: P07954
is: SBO:0000252
initial concentration: NaN
name: FH
is encoded by: hsa:2271

http://identifiers.org/biomodels.db/MODEL1310110042#_0130ef2e_498f_413c_86ce_8a5eb389fefe
initial concentration: NaN
name: B3GNT3
is encoded by: hsa:10331
boundary condition: true
has only substance units: false
is: Q9Y2A9
type: Species
is: SBO:0000252
constant: false
initial amount: NaN

metaR r0202
reactant: MODEL1310110042#
notes: GENE_ASSOCIATION: SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: 1.1.1.8 Confidence Level: 0 AUTHORS: PMID:17045662,PMID:7772607 NOTES:
name: sn-Glycerol-3-phosphate:NAD+ 2-oxidoreductase Glycerophospholipid metabolism EC:1.1.1.8
kinetic law: MODEL1310110042#
is: SBO:0000176
product: MODEL1310110042#
fast: false
reversible: true
type: Reaction
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110042#_e2bbfc01_2661_4362_8f20_8eb6aeb2925f
has only substance units: false
is: SBO:0000252
initial concentration: NaN
is encoded by: hsa:4758
type: Species
name: NEU1
constant: false
boundary condition: true
initial amount: NaN
is: Q99519

http://identifiers.org/biomodels.db/MODEL1310110042#_4c785845_4f0e_4e7a_a4e9_5d9f2f5ef799
type: Species
is: B7Z4Y6
name: ALPL
has only substance units: false
is: SBO:0000252
constant: false
is encoded by: hsa:249
boundary condition: true
initial concentration: NaN
initial amount: NaN

metaR S6T17g
kinetic law: MODEL1310110042#
reversible: false
notes: GENE_ASSOCIATION: (23563.2) or (9435.1) or (23563.1) or (10164.1) or (4166.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: Confidence Level: 4 AUTHORS: PMID:10330415,PMID:10491328,PMID:10913333,PMID:11278593,PMID:12403612,PMID:12855678,PMID:9722682 NOTES:NCD
reactant: MODEL1310110042#
type: Reaction
is: SBO:0000176
name: galactose/N-acetylglucosamine 6-O-sulfotransferase, Golgi apparatus
is described by: ECO:0000000
modifier: MODEL1310110042#
fast: false
product: MODEL1310110042#

metaR EX 3deccrn
kinetic law: MODEL1310110042#
reactant: MODEL1310110042#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for 3-hydroxydecanoyl carnitine
type: Reaction

metaM l2n2m2mn l
is: HMDB00143
boundary condition: false
notes: FORMULA: C54H91N3O41 CHARGE: 0
initial amount: NaN
type: Species
is: SBO:0000247
has only substance units: false
is: CHEBI:12936
name: de-Fuc, reducing GlcNAc removed, de-Sia form of PA6 (w/o peptide linkage)
constant: false
initial concentration: 1.0

metaR RE1845C
is: SBO:0000176
name: RE1845
reactant: MODEL1310110042#
notes: GENE_ASSOCIATION: (570.1) SUBSYSTEM: Bile acid synthesis EC Number: 2.3.1.65 Confidence Level: 0 AUTHORS: PMID:11980911 NOTES:IT - removed 4 h[c] from compEHMN reaction as they were not necessary
type: Reaction
is described by: ECO:0000000
modifier: MODEL1310110042#
product: MODEL1310110042#
kinetic law: MODEL1310110042#
is version of: http://identifiers.org/ec-code/2.3.1.65
fast: false
reversible: true

metaR KHK2
notes: GENE_ASSOCIATION: (3795.1) or (3795.2) SUBSYSTEM: Glyoxylate and dicarboxylate metabolism EC Number: 2.7.1.3 Confidence Level: 4 AUTHORS: PMID:2996495,PMID:6284103,PMID:6298387 NOTES:NCD
kinetic law: MODEL1310110042#
modifier: MODEL1310110042#
reversible: false
fast: false
product: MODEL1310110042#
name: ketohexokinase (D-xylulose)
is: SBO:0000176
reactant: MODEL1310110042#
is version of: http://identifiers.org/ec-code/2.7.1.3
is described by: ECO:0000269
type: Reaction

metaM ksi deg16 l
has only substance units: false
constant: false
boundary condition: false
initial amount: NaN
is: CHEBI:16953
initial concentration: 1.0
is: SBO:0000247
type: Species
notes: FORMULA: C160H258N11O137S7 CHARGE: -7
name: keratan sulfate I, degradation product 16
is: HMDB00812

metaR ACNACNGALGBSIDEtg
fast: false
name: acnacngalgbside hs intracellular transport
kinetic law: MODEL1310110042#
is: SBO:0000185
reactant: MODEL1310110042#
is described by: ECO:0000000
product: MODEL1310110042#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 1 AUTHORS: PMID:8206147 NOTES:unknown mechanism for transport - intracellular transport occurs, most details are unknown - see for example Varki glycobiology text or numerous reviews (PMID: 8206147) NJ
reversible: true
type: Reaction

metaR PETOHMm hs
reversible: false
name: phosphatidylethanolamine N-methyltransferase
fast: false
type: Reaction
product: MODEL1310110042#
is version of: http://identifiers.org/ec-code/2.1.1.17
notes: GENE_ASSOCIATION: (10400.2) or (10400.1) or (10400.3) SUBSYSTEM: Glycerophospholipid metabolism EC Number: 2.1.1.17 Confidence Level: 2 AUTHORS: PMID:9989271 NOTES:for human Catalyzes three sequential methylation of phosphatidylethanolamine (PE) by AdoMet, thus producing phosphatidylcholine (PC). [Swiss-prot] NJ
reactant: MODEL1310110042#
modifier: MODEL1310110042#
is described by: ECO:0000254
is: SBO:0000176
kinetic law: MODEL1310110042#

metaR EX appnn LPAREN e RPAREN
kinetic law: MODEL1310110042#
reactant: MODEL1310110042#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: (+)-alpha-Pinene exchange
type: Reaction

metaM drib e
notes: FORMULA: C5H10O4 CHARGE: 0 INCHI: InChI=1S/C5H10O4/c6-2-1-4(8)5(9)3-7/h2,4-5,7-9H,1,3H2/t4-,5+/m0/s1 EHMN_ABBREVIATION: C01801
is: SBO:0000247
has only substance units: false
is: CHEBI:28816
constant: false
boundary condition: false
initial concentration: 1.0
name: 2-deoxy-D-ribose
initial amount: NaN
type: Species
is: HMDB03224

metaM arachdcrn r
boundary condition: false
is: HMDB06523
is: SBO:0000247
constant: false
initial amount: NaN
is: CHEBI:57368
has only substance units: false
type: Species
name: C20:4 carnitine
initial concentration: 1.0
notes: FORMULA: C27H45NO4 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC12236

metaM hpdcacoa m
initial concentration: 1.0
type: Species
is: HMDB06497
notes: FORMULA: C38H64N7O17P3S CHARGE: -4 INCHI: InChI=1/C38H68N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-29(47)66-22-21-40-28(46)19-20-41-36(50)33(49)38(2,3)24-59-65(56,57)62-64(54,55)58-23-27-32(61-63(51,52)53)31(48)37(60-27)45-26-44-30-34(39)42-25-43-35(30)45/h25-27,31-33,37,48-49H,4-24H2,1-3H3,(H,40,46)(H,41,50)(H,54,55)(H,56,57)(H2,39,42,43)(H2,51,52,53)/t27-,31-,32-,33+,37-/m1/s1
initial amount: NaN
boundary condition: false
has only substance units: false
constant: false
is: SBO:0000247
name: heptadecanoyl coa

metaM trdrd m
notes: FORMULA: XH2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00289 EHMN_ABBREVIATION: C00342
is: CHEBI:15967
initial concentration: 1.0
has only substance units: false
name: Reduced thioredoxin
constant: false
is: SBO:0000247
initial amount: NaN
type: Species
boundary condition: false

metaR r0009
is version of: http://identifiers.org/ec-code/3.6.1.1
is described by: ECO:0000000
name: Pyrophosphate phosphohydrolase EC:3.6.1.1
notes: GENE_ASSOCIATION: (AI990637.1) or (64077.1) or (5464.1) or (27068.1) SUBSYSTEM: Purine catabolism EC Number: 3.6.1.1 Confidence Level: 0 AUTHORS: PMID:10542310,PMID:16300924 NOTES:IT - fixed proton
modifier: MODEL1310110042#
reactant: MODEL1310110042#
product: MODEL1310110042#
reversible: false
type: Reaction
kinetic law: MODEL1310110042#
fast: false
is: SBO:0000176

metaM txa2 e
has only substance units: false
initial amount: NaN
is: HMDB01452
initial concentration: 1.0
notes: FORMULA: C20H31O5 CHARGE: -1 INCHI: InChI=1S/C20H32O5/c1-2-3-6-9-15(21)12-13-17-16(18-14-20(24-17)25-18)10-7-4-5-8-11-19(22)23/h4,7,12-13,15-18,20-21H,2-3,5-6,8-11,14H2,1H3,(H,22,23)/p-1/b7-4-,13-12+/t15-,16+,17+,18-,20+/m0/s1 EHMN_ABBREVIATION: C02198
is: SBO:0000247
constant: false
boundary condition: false
name: thromboxane A2(1-)
type: Species
is: CHEBI:57445

metaM ksii core4 pre1 g
boundary condition: false
notes: FORMULA: C36H60N3O25X CHARGE: 0
name: keratan sulfate II biosynthesis, precursor 1
type: Species
is: SBO:0000247
has only substance units: false
initial concentration: 1.0
constant: false
is: CHEBI:28067
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110042#_133a8878_c4d5_4b95_b0e0_2b0525df87fd
type: Species
constant: false
is: SBO:0000252
name: HSD3B1
is encoded by: hsa:3283
initial amount: NaN
is: P14060
boundary condition: true
initial concentration: NaN
has only substance units: false

metaR NTP3e
product: MODEL1310110042#
is version of: http://identifiers.org/ec-code/3.6.1.6
is described by: ECO:0000269
reversible: false
type: Reaction
fast: false
is: SBO:0000176
reactant: MODEL1310110042#
notes: GENE_ASSOCIATION: (124583.1) SUBSYSTEM: Nucleotide interconversion EC Number: 3.6.1.15 Confidence Level: 4 AUTHORS: PMID:12234496,PMID:12600208 NOTES:
kinetic law: MODEL1310110042#
name: nucleoside-triphosphatase (GTP)
modifier: MODEL1310110042#

metaR INSTt4
reversible: true
modifier: MODEL1310110042#
name: inositol transport via sodium symport
type: Reaction
kinetic law: MODEL1310110042#
is: SBO:0000185
fast: false
is described by: ECO:0000269
reactant: MODEL1310110042#
notes: GENE_ASSOCIATION: (6526.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12748858,PMID:1372904,PMID:15546855,PMID:7537337,PMID:7789985 NOTES:NCD
product: MODEL1310110042#

metaR GALASE8ly
is described by: ECO:0000000
reversible: false
is: SBO:0000176
modifier: MODEL1310110042#
name: beta-galactosidase, lysosomal
is version of: http://identifiers.org/ec-code/3.2.1.18
fast: false
is version of: http://identifiers.org/ec-code/3.2.1.23
reactant: MODEL1310110042#
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) or (5476.1) and (2720.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.23 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD
kinetic law: MODEL1310110042#
product: MODEL1310110042#
type: Reaction
is version of: http://identifiers.org/ec-code/3.1.6.4
is version of: http://identifiers.org/ec-code/3.4.16.5

http://identifiers.org/biomodels.db/MODEL1310110042#_dac39a8e_1215_42a3_9c21_19abae74202a
boundary condition: true
has only substance units: false
initial amount: NaN
initial concentration: NaN
type: Species
is encoded by: hsa:3033
name: HADH
is: Q16836
is: SBO:0000252
constant: false

metaR ATPH1e
kinetic law: MODEL1310110042#
product: MODEL1310110042#
reactant: MODEL1310110042#
is version of: http://identifiers.org/ec-code/3.6.1.5
type: Reaction
name: ATP diphosphohydrolase
is: SBO:0000176
fast: false
is version of: http://identifiers.org/ec-code/3.6.1.6
reversible: false
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (954.1) or (954.2) or (953.1) or (956.1) or (955.1) or (957.1) SUBSYSTEM: Nucleotide interconversion EC Number: 3.6.1.5 Confidence Level: 4 AUTHORS: PMID:8955160,PMID:9676430 NOTES:IT
modifier: MODEL1310110042#

metaM ump g
is: HMDB00288
is: SBO:0000247
initial concentration: 1.0
boundary condition: false
notes: FORMULA: C9H11N2O9P CHARGE: -2 INCHI: InChI=1S/C9H13N2O9P/c12-5-1-2-11(9(15)10-5)8-7(14)6(13)4(20-8)3-19-21(16,17)18/h1-2,4,6-8,13-14H,3H2,(H,10,12,15)(H2,16,17,18)/p-2/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00105 EHMN_ABBREVIATION: C00105
initial amount: NaN
type: Species
is: CHEBI:57865
name: UMP(2-)
constant: false
has only substance units: false

metaR r0779
product: MODEL1310110042#
fast: false
is described by: ECO:0000000
name: 3-Hydroxy-2-methylpropanoyl-CoA hydrolase EC:3.1.2.4
reversible: false
is: SBO:0000176
notes: GENE_ASSOCIATION: (1892.1) or (1962.1) or (3030.1) SUBSYSTEM: Unassigned EC Number: 3.1.2.4 Confidence Level: 0 AUTHORS: PMID:11580916,PMID:8188708 NOTES:
kinetic law: MODEL1310110042#
is version of: http://identifiers.org/ec-code/4.2.1.17
type: Reaction
is version of: http://identifiers.org/ec-code/1.1.1.35
reactant: MODEL1310110042#
modifier: MODEL1310110042#

metaM crm hs l
boundary condition: false
has only substance units: false
name: N-acylsphingosine
is: CHEBI:52639
notes: FORMULA: C18H36NO2FULLRCO CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC01990 EHMN_ABBREVIATION: C00195
constant: false
initial concentration: 1.0
type: Species
initial amount: NaN
is: SBO:0000247

metaM glyclt c
is: SBO:0000247
is: CHEBI:29805
initial amount: NaN
name: glycolate
has only substance units: false
is: HMDB00115
boundary condition: false
type: Species
initial concentration: 1.0
notes: FORMULA: C2H3O3 CHARGE: -1 INCHI: InChI=1S/C2H4O3/c3-1-2(4)5/h3H,1H2,(H,4,5)/p-1 EHMN_ABBREVIATION: C00160
constant: false

metaR PPItm
fast: false
kinetic law: MODEL1310110042#
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 1 AUTHORS: added during gap-filling. NOTES:added during gap-filling.
type: Reaction
reactant: MODEL1310110042#
product: MODEL1310110042#
is: SBO:0000185
name: diphopshate transporter, mitochondrial
is described by: ECO:0000134

metaR EX o2s LPAREN e RPAREN
kinetic law: MODEL1310110042#
reactant: MODEL1310110042#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Superoxide anion exchange
type: Reaction

metaR S23Tg
is version of: http://identifiers.org/ec-code/2.4.99.4
name: beta-galactoside alpha-2,3-sialyltransferase (T antigen)
reversible: false
type: Reaction
product: MODEL1310110042#
reactant: MODEL1310110042#
is: SBO:0000176
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (6482.1) or (6482.2) SUBSYSTEM: O-glycan synthesis EC Number: 2.4.99.4 Confidence Level: 4 AUTHORS: PMID:10504389,PMID:8027041 NOTES:NCD
fast: false
modifier: MODEL1310110042#
kinetic law: MODEL1310110042#

metaM hexdicoa c
is: SBO:0000247
name: hexadecanedioylcoa
initial concentration: 1.0
type: Species
is: HMDB02014
constant: false
notes: FORMULA: C37H59N7O19P3S CHARGE: -5
initial amount: NaN
has only substance units: false
boundary condition: false

metaR r1726
reactant: MODEL1310110042#
modifier: MODEL1310110042#
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
name: Y+LAT2 Utilized transport
kinetic law: MODEL1310110042#
is described by: ECO:0000000
fast: false
product: MODEL1310110042#
type: Reaction
reversible: false
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110042#_6f795411_f9fc_4ed8_841a_5f78612c4ac1
initial concentration: NaN
boundary condition: true
is: Q9BT22
name: ALG1
is: SBO:0000252
type: Species
is encoded by: hsa:56052
initial amount: NaN
has only substance units: false
constant: false

metaR ACNACNGALGBSIDEte
reactant: MODEL1310110042#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 1 AUTHORS: PMID:8206147 NOTES:unknown mechanism for transport - intracellular transport occurs, most details are unknown - see for example Varki glycobiology text or numerous reviews (PMID: 8206147) - extracellular transport is also made available since metabolites can get to outer plasma membrane NJ
reversible: true
name: acnacngalgbside hs transport
is: SBO:0000185
product: MODEL1310110042#
kinetic law: MODEL1310110042#
is described by: ECO:0000000
fast: false

http://identifiers.org/biomodels.db/MODEL1310110042#_29e55df8_75b0_44d1_a3e6_3ab91594bb5f
has only substance units: false
type: Species
name: NPR2
initial amount: NaN
is: SBO:0000252
initial concentration: NaN
constant: false
boundary condition: true
is encoded by: hsa:4882

http://identifiers.org/biomodels.db/MODEL1310110042#_68d1e813_512d_4b5f_bcb6_601d25b789b1
constant: false
initial concentration: NaN
type: Species
is encoded by: hsa:AI990637
has only substance units: false
name: _AI990637_1_x
boundary condition: true
is: SBO:0000252
initial amount: NaN

metaR GAPD
notes: GENE_ASSOCIATION: (2597.1) or (26330.1) SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: 1.2.1.12 Confidence Level: 0 AUTHORS: PMID:10714828 NOTES:SMP. Same reaction as GAPDH, but localied to spermatids. NOTE: I think "glyceroyl" in this and many other reactions should be "glycerol". There are "glyceroyl" compounds, but I don't think that is what is intended here.
is: SBO:0000176
is described by: ECO:0000134
reactant: MODEL1310110042#
reversible: true
name: glyceraldehyde-3-phosphate dehydrogenase
modifier: MODEL1310110042#
product: MODEL1310110042#
is version of: http://identifiers.org/ec-code/1.2.1.12
type: Reaction
fast: false
kinetic law: MODEL1310110042#

metaR EX oagt3 hs LPAREN e RPAREN
kinetic law: MODEL1310110042#
reactant: MODEL1310110042#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 9-O-Acetylated GT3 (homo sapiens) exchange
type: Reaction

metaR TIGCRNe
kinetic law: MODEL1310110042#
product: MODEL1310110042#
reactant: MODEL1310110042#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of tiglyl carnitine into the extra cellular fluid
type: Reaction

metaM cdpdag hs m
boundary condition: false
is: SBO:0000247
initial amount: NaN
name: CDP-diacylglycerol(2-)
is: CHEBI:58332
constant: false
initial concentration: 1.0
has only substance units: false
type: Species
notes: FORMULA: C12H17N3O11P2FULLRCO2FULLR2CO2 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC02078

metaR GLUNm
modifier: MODEL1310110042#
name: glutaminase (mitochondrial)
reversible: false
type: Reaction
fast: false
notes: GENE_ASSOCIATION: (2744.1) or (27165.2) or (27165.1) SUBSYSTEM: Glutamate metabolism EC Number: 3.5.1.2 Confidence Level: 4 AUTHORS: PMID:10719215,PMID:12579526 NOTES:
kinetic law: MODEL1310110042#
reactant: MODEL1310110042#
is described by: ECO:0000269
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.5.1.2
product: MODEL1310110042#

metaM lnlc e
constant: false
initial concentration: 1.0
notes: FORMULA: C18H31O2 CHARGE: -1 INCHI: InChI=1S/C18H32O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20/h6-7,9-10H,2-5,8,11-17H2,1H3,(H,19,20)/p-1/b7-6-,10-9-
boundary condition: false
initial amount: NaN
name: linoleate
type: Species
is: HMDB00673
is: SBO:0000247
has only substance units: false
is: CHEBI:30245

metaR FAOXC225m
kinetic law: MODEL1310110042#
product: MODEL1310110042#
reactant: MODEL1310110042#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: isomerization(C22:5)m
type: Reaction

metaM nadp c
initial amount: NaN
is: C00006
name: Nicotinamide adenine dinucleotide phosphate
is: CHEBI:58349
initial concentration: 1.0
boundary condition: false
is: HMDB00217
is: SBO:0000247
type: Species
constant: false
has only substance units: false
notes: FORMULA: C21H25N7O17P3 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00016 EHMN_ABBREVIATION: C00006

metaM mi4p D c
constant: false
is: HMDB01313
notes: FORMULA: C6H11O9P CHARGE: -2 INCHI: InChI=1S/C6H13O9P/c7-1-2(8)4(10)6(5(11)3(1)9)15-16(12,13)14/h1-11H,(H2,12,13,14)/p-2/t1-,2-,3-,4+,5-,6-/m0/s1
type: Species
has only substance units: false
initial concentration: 1.0
is: CHEBI:58469
name: 1D-myo-inositol 4-phosphate(2-)
boundary condition: false
is: SBO:0000247
initial amount: NaN

metaR RBFK
is: SBO:0000176
name: riboflavin kinase
modifier: MODEL1310110042#
reactant: MODEL1310110042#
kinetic law: MODEL1310110042#
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (55312.1) SUBSYSTEM: Vitamin B2 metabolism EC Number: Confidence Level: 4 AUTHORS: NOTES:
is version of: http://identifiers.org/ec-code/2.7.1.26
type: Reaction
fast: false
reversible: false
product: MODEL1310110042#

metaM CE5101 m
boundary condition: false
name: 1-phosphatidyl-1D-myo-inositol 5-phosphate(3-)
type: Species
is: CHEBI:57795
is: SBO:0000247
has only substance units: false
initial amount: NaN
initial concentration: 1.0
notes: FORMULA: C11H15O16P2R2 CHARGE: -3 EHMN_ABBREVIATION: CE5101
constant: false

metaR PETHCT
type: Reaction
fast: false
kinetic law: MODEL1310110042#
modifier: MODEL1310110042#
is version of: http://identifiers.org/ec-code/2.7.7.14
is described by: ECO:0000269
product: MODEL1310110042#
is: SBO:0000176
reversible: false
name: phosphoethanolamine cytidyltransferase
reactant: MODEL1310110042#
notes: GENE_ASSOCIATION: (5833.1) SUBSYSTEM: Glycerophospholipid metabolism EC Number: 2.7.7.14 Confidence Level: 4 AUTHORS: NOTES:NCD

http://identifiers.org/biomodels.db/MODEL1310110042#_c300b6ee_b449_448a_b6d2_57d1311385db
is encoded by: hsa:506
has only substance units: false
is: P06576
constant: false
type: Species
name: ATP5B
is: SBO:0000252
initial concentration: NaN
boundary condition: true
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110042#_633fe9ce_d055_47be_b1ec_e3acc4a92da0
initial concentration: NaN
boundary condition: true
initial amount: NaN
has only substance units: false
type: Species
constant: false
is encoded by: hsa:54
name: ACP5
is: P13686
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110042#_b6fa456f_dba4_4d10_93b5_944b5813ce3e
initial amount: NaN
is: SBO:0000252
type: Species
name: AHCY
has only substance units: false
constant: false
boundary condition: true
is encoded by: hsa:191
is: B3KUN3
initial concentration: NaN

metaM lnlncgcoa m
has only substance units: false
notes: FORMULA: C39H60N7O17P3S CHARGE: -4 INCHI: InChI=1S/C39H64N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-30(48)67-23-22-41-29(47)20-21-42-37(51)34(50)39(2,3)25-60-66(57,58)63-65(55,56)59-24-28-33(62-64(52,53)54)32(49)38(61-28)46-27-45-31-35(40)43-26-44-36(31)46/h8-9,11-12,14-15,26-28,32-34,38,49-50H,4-7,10,13,16-25H2,1-3H3,(H,41,47)(H,42,51)(H,55,56)(H,57,58)(H2,40,43,44)(H2,52,53,54)/p-4/b9-8-,12-11-,15-14-/t28-,32-,33-,34+,38-/m1/s1 EHMN_ABBREVIATION: C03035
constant: false
is: HMDB06368
initial concentration: 1.0
is: CHEBI:57363
type: Species
initial amount: NaN
name: gamma-linolenoyl-CoA(4-)
is: SBO:0000247
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110042#_8da25999_5347_453d_a70f_4a052772e272
is: SBO:0000252
boundary condition: true
constant: false
initial amount: NaN
name: ME3
initial concentration: NaN
is encoded by: hsa:10873
is: Q6TCH8
type: Species
has only substance units: false

metaM 2docopencoa m
initial amount: NaN
initial concentration: 1.0
has only substance units: false
name: 2,7,10,13,16-docosapentenoylcoa
is: http://identifiers.org/pubchem.compound/24892790
notes: FORMULA: C43H64N7O17P3S CHARGE: -4
is: SBO:0000247
constant: false
type: Species
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110042#_124fd64e_41d1_40f3_a9c4_6a822db50851
constant: false
name: ELOVL5
initial amount: NaN
has only substance units: false
type: Species
is encoded by: hsa:60481
boundary condition: true
is: F6SH78
is: SBO:0000252
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110042#_bc6a8158_caf1_4f70_8830_1330cf66a76b
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:3030
is: E9KL44
constant: false
name: HADHA
is: SBO:0000252
has only substance units: false
boundary condition: true
type: Species

metaR GUAD
kinetic law: MODEL1310110042#
is version of: http://identifiers.org/ec-code/3.5.4.3
name: guanine deaminase
modifier: MODEL1310110042#
reversible: false
is described by: ECO:0000269
type: Reaction
reactant: MODEL1310110042#
fast: false
notes: GENE_ASSOCIATION: (9615.1) SUBSYSTEM: Purine catabolism EC Number: 3.5.4.3 Confidence Level: 4 AUTHORS: PMID:10075721 NOTES:
product: MODEL1310110042#
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110042#_a48a7397_7715_436d_b3b3_79d32e4b4339
constant: false
name: PIGF
is encoded by: hsa:5281
has only substance units: false
type: Species
is: SBO:0000252
is: Q07326
boundary condition: true
initial concentration: NaN
initial amount: NaN

metaR TDCHOLAtx
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: NOTES:unknown mechanism, however bile acids need to be secreted out of the cell NJ
name: bile acid intracellular transport
is described by: ECO:0000000
reactant: MODEL1310110042#
kinetic law: MODEL1310110042#
product: MODEL1310110042#
fast: false
type: Reaction
is: SBO:0000185
reversible: true

metaR DESAT22 2p
reversible: false
type: Reaction
is: SBO:0000176
name: fatty acyl-CoA desaturase (n-C22:5CoA -> n-C22:6CoA)
kinetic law: MODEL1310110042#
is described by: ECO:0000000
product: MODEL1310110042#
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid synthesis EC Number: 1.14.19.1 Confidence Level: 4 AUTHORS: NOTES:
fast: false
reactant: MODEL1310110042#

metaR CYANtm
reactant: MODEL1310110042#
product: MODEL1310110042#
name: Cyanide transport via diffusion (mitochondrial)
reversible: true
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: NOTES:assumed to be readily diffusible MM
is described by: ECO:0000000
fast: false
kinetic law: MODEL1310110042#
type: Reaction

metaM c4crn c
is: HMDB02013
initial amount: NaN
initial concentration: 1.0
has only substance units: false
notes: FORMULA: C11H21NO4 CHARGE: 0
is: http://identifiers.org/pubchem.compound/213144
constant: false
is: SBO:0000247
boundary condition: false
name: butyryl carnitine
type: Species
is: C02862

http://identifiers.org/biomodels.db/MODEL1310110042#_c85e7210_06f7_4e46_a534_cebe5cec90c3
name: _AA177072_1_x
is encoded by: hsa:AA177072
initial amount: NaN
type: Species
has only substance units: false
boundary condition: true
is: SBO:0000252
constant: false
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110042#_5d37e231_61f3_40a2_8bc7_46c29d72bc84
initial amount: NaN
is: B7Z1R0
is: SBO:0000252
constant: false
is encoded by: hsa:57282
initial concentration: NaN
name: SLC4A10
type: Species
boundary condition: true
has only substance units: false

metaM tethex3 c
has only substance units: false
is: HMDB02007
boundary condition: false
name: tetracosahexaenoic acid, n-3
constant: false
initial concentration: 1.0
initial amount: NaN
is: SBO:0000247
notes: FORMULA: C24H35O2 CHARGE: -1 INCHI: InChI=1/C24H36O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-24(25)26/h3-4,6-7,9-10,12-13,15-18H,2,5,8,11,14,19-23H2,1H3,(H,25,26)/b4-3-,7-6-,10-9-,13-12-,16-15-,18-17-
type: Species

metaR TXA2te
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:unknown mechanism for transport - known to be secreted from cells - unknown mechanism or pathway, TXA2tc -> TXA2te to get to EC space NJ
name: thromboxane A2 transport
product: MODEL1310110042#
fast: false
reactant: MODEL1310110042#
is described by: ECO:0000000
reversible: true
is: SBO:0000185
type: Reaction
kinetic law: MODEL1310110042#

http://identifiers.org/biomodels.db/MODEL1310110042#_efe37e74_cd2d_4b3f_9126_74687ebb36f2
initial amount: NaN
boundary condition: true
has only substance units: false
type: Species
is: SBO:0000252
name: ALPP
is: P05187
initial concentration: NaN
is encoded by: hsa:250
constant: false

http://identifiers.org/biomodels.db/MODEL1310110042#_6f952503_7ef1_41df_9958_b77f2e5aef27
name: SLC43A2
has only substance units: false
initial amount: NaN
is encoded by: hsa:124935
is: Q8N370
is: SBO:0000252
initial concentration: NaN
type: Species
boundary condition: true
constant: false

metaR C16DCc
kinetic law: MODEL1310110042#
product: MODEL1310110042#
reactant: MODEL1310110042#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: production of hexadecanedioylcarnitine
type: Reaction

metaM ocdcea c
boundary condition: false
notes: FORMULA: C18H33O2 CHARGE: -1
initial concentration: 1.0
type: Species
is: HMDB00207
is: C00712
is: CHEBI:0
initial amount: NaN
constant: false
name: octadecenoate (n-C18:1)
is: SBO:0000247
has only substance units: false

metaM ocdececrn c
is: SBO:0000247
constant: false
initial concentration: 1.0
has only substance units: false
initial amount: NaN
boundary condition: false
notes: FORMULA: C25H47NO4 CHARGE: 0
name: 11-octadecenoyl carnitine
type: Species
is: HMDB06351

metaR AHEXASE2ly
is: SBO:0000176
type: Reaction
kinetic law: MODEL1310110042#
name: beta-N-acetylhexosaminidase, lysosomal
modifier: MODEL1310110042#
fast: false
is described by: ECO:0000000
reversible: false
notes: GENE_ASSOCIATION: (3074.1) or (3073.1) or (3073.1 and 3074.1) SUBSYSTEM: N-glycan degradation EC Number: 3.2.1.52 Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12706724 NOTES:NCD
product: MODEL1310110042#
reactant: MODEL1310110042#
is version of: http://identifiers.org/ec-code/3.2.1.52

metaM ksii core2 pre10 g
boundary condition: false
name: keratan sulfate II biosynthesis, precursor 10
initial concentration: 1.0
is: SBO:0000247
initial amount: NaN
has only substance units: false
type: Species
notes: FORMULA: C81H130N6O64S2X CHARGE: -3
is: CHEBI:28067
constant: false

metaM tdcoa c
constant: false
type: Species
name: Tetradecanoyl-CoA (n-C14:0CoA)
initial concentration: 1.0
is: C02593
has only substance units: false
is: SBO:0000247
initial amount: NaN
notes: FORMULA: C35H58N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00971 EHMN_ABBREVIATION: C02593
boundary condition: false
is: CHEBI:57385
is: HMDB01521

metaR FADtx
product: MODEL1310110042#
reactant: MODEL1310110042#
type: Reaction
name: FAD transporter, peroxisomal
kinetic law: MODEL1310110042#
fast: false
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 1 AUTHORS: NOTES:most likely NOT physiological - detailed information about the peroxisomal transporters has not yet been achieved - this transport is most likely dependent on a concomitant energy consuming reaction (human ABC peroxisomal transporters: PEX family - check in future for new research articles describing biochemistry and stoichiometry) NJ
is: SBO:0000185
reversible: true

metaM C05965 e
is: SBO:0000247
initial amount: NaN
constant: false
is: HMDB04243
notes: FORMULA: C20H31O4 CHARGE: -1 INCHI: InChI=1S/C20H32O4/c1-2-3-4-5-10-13-16-19(24-23)17-14-11-8-6-7-9-12-15-18-20(21)22/h7-11,13-14,17,19,23H,2-6,12,15-16,18H2,1H3,(H,21,22)/p-1/b9-7-,11-8-,13-10-,17-14+/t19-/m0/s1 EHMN_ABBREVIATION: C05965
initial concentration: 1.0
has only substance units: false
type: Species
boundary condition: false
is: CHEBI:57444
name: 12(S)-HPETE(1-)

metaM ala B c
type: Species
boundary condition: false
name: beta-alanine
constant: false
initial concentration: 1.0
is: HMDB00056
has only substance units: false
is: SBO:0000247
initial amount: NaN
is: CHEBI:16958
notes: FORMULA: C3H7NO2 CHARGE: 0 INCHI: InChI=1S/C3H7NO2/c4-2-1-3(5)6/h1-2,4H2,(H,5,6) HEPATONET_1.0_ABBREVIATION: HC00100

http://identifiers.org/biomodels.db/MODEL1310110042#_ae566541_1dae_4607_92ef_b55112b3a2d2
initial concentration: NaN
has only substance units: false
is: SBO:0000252
name: _22305_2_c
initial amount: NaN
constant: false
boundary condition: true
type: Species
is encoded by: hsa:22305

metaR ADPACDAc
kinetic law: MODEL1310110042#
product: MODEL1310110042#
reactant: MODEL1310110042#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: activation of adipic acid for formation of adipoyl carnitine
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110042#_f6f4f949_35db_48ce_a0aa_aaa51e605ddb
initial concentration: NaN
is encoded by: hsa:10846
is: SBO:0000252
type: Species
boundary condition: true
has only substance units: false
constant: false
initial amount: NaN
name: PDE10A
is: Q9Y233

metaM but e
constant: false
is: HMDB00039
notes: FORMULA: C4H7O2 CHARGE: -1 INCHI: InChI=1S/C4H8O2/c1-2-3-4(5)6/h2-3H2,1H3,(H,5,6)/p-1 HEPATONET_1.0_ABBREVIATION: HC00223 EHMN_ABBREVIATION: C00246
boundary condition: false
is: CHEBI:17968
initial amount: NaN
has only substance units: false
is: SBO:0000247
name: butyrate
type: Species
initial concentration: 1.0

metaM utp c
type: Species
is: SBO:0000247
is: CHEBI:46398
name: UTP
initial amount: NaN
initial concentration: 1.0
constant: false
is: HMDB00285
is: C00075
notes: FORMULA: C9H11N2O15P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00077 EHMN_ABBREVIATION: C00075
has only substance units: false
boundary condition: false

metaR TRDR
kinetic law: MODEL1310110042#
notes: GENE_ASSOCIATION: (7296.3) or (7296.1) or (7296.4) or (7296.2) SUBSYSTEM: Nucleotide interconversion EC Number: 1.8.1.9 Confidence Level: 4 AUTHORS: PMID:8577704,PMID:8999974 NOTES:
type: Reaction
fast: false
modifier: MODEL1310110042#
reactant: MODEL1310110042#
is described by: ECO:0000269
product: MODEL1310110042#
name: thioredoxin reductase (NADPH)
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.8.1.9
reversible: false

metaM txa2 c
type: Species
initial amount: NaN
initial concentration: 1.0
boundary condition: false
notes: FORMULA: C20H31O5 CHARGE: -1 INCHI: InChI=1S/C20H32O5/c1-2-3-6-9-15(21)12-13-17-16(18-14-20(24-17)25-18)10-7-4-5-8-11-19(22)23/h4,7,12-13,15-18,20-21H,2-3,5-6,8-11,14H2,1H3,(H,22,23)/p-1/b7-4-,13-12+/t15-,16+,17+,18-,20+/m0/s1 EHMN_ABBREVIATION: C02198
is: SBO:0000247
is: HMDB01452
is: CHEBI:57445
has only substance units: false
constant: false
name: thromboxane A2(1-)

http://identifiers.org/biomodels.db/MODEL1310110042#_4bdd4190_aed1_4b04_9c7c_e9a6ee920585
name: GALNT5
has only substance units: false
initial concentration: NaN
constant: false
boundary condition: true
type: Species
initial amount: NaN
is encoded by: hsa:11227
is: A5PKZ1
is: SBO:0000252

metaR HSD3B7P
kinetic law: MODEL1310110042#
is version of: http://identifiers.org/ec-code/1.1.1.181
is: SBO:0000176
modifier: MODEL1310110042#
product: MODEL1310110042#
reactant: MODEL1310110042#
fast: false
reversible: false
name: hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 7
type: Reaction
notes: GENE_ASSOCIATION: (80270.1) SUBSYSTEM: Bile acid synthesis EC Number: Confidence Level: 4 AUTHORS: NOTES:
is described by: ECO:0000269

metaM ump c
initial concentration: 1.0
has only substance units: false
is: HMDB00288
name: UMP
notes: FORMULA: C9H11N2O9P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00105 EHMN_ABBREVIATION: C00105
is: CHEBI:57865
boundary condition: false
type: Species
constant: false
is: C00105
is: SBO:0000247
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110042#_27236086_35bd_4699_8a4e_3248cc3166b0
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:AU149534
has only substance units: false
constant: false
initial concentration: NaN
name: _AU149534_1_c
type: Species
boundary condition: true

metaR G14Tg
is version of: http://identifiers.org/ec-code/2.4.1.22
reactant: MODEL1310110042#
is version of: http://identifiers.org/ec-code/2.4.1.38
type: Reaction
modifier: MODEL1310110042#
name: beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase
kinetic law: MODEL1310110042#
product: MODEL1310110042#
is version of: http://identifiers.org/ec-code/2.4.1.90
fast: false
is described by: ECO:0000269
is: SBO:0000176
reversible: false
notes: GENE_ASSOCIATION: (9334.1) or (2683.1) or (8704.1) or (8703.1) or (8704.2) SUBSYSTEM: N-glycan synthesis EC Number: 2.4.1.38 Confidence Level: 4 AUTHORS: PMID:9597550 NOTES:NCD

http://identifiers.org/biomodels.db/MODEL1310110042#_d161006f_e813_4159_9802_8d5429e13eba
is: SBO:0000252
constant: false
boundary condition: true
type: Species
initial amount: NaN
is: P22352
name: GPX3
has only substance units: false
is encoded by: hsa:2878
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110042#_8ebcaece_1f19_49d0_819c_0d6e25f09b81
constant: false
initial amount: NaN
initial concentration: NaN
is: P07954
is encoded by: hsa:2271
is: SBO:0000252
name: FH
type: Species
has only substance units: false
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110042#_8ff2a6a2_3ca3_405b_ad3f_664f02c2cc5e
initial concentration: NaN
initial amount: NaN
boundary condition: true
name: SLC27A4
constant: false
is encoded by: hsa:10999
has only substance units: false
is: SBO:0000252
is: Q6P1M0
type: Species

metaM c4crn e
notes: FORMULA: C11H21NO4 CHARGE: 0
is: HMDB02013
has only substance units: false
initial amount: NaN
boundary condition: false
name: butyryl carnitine
type: Species
initial concentration: 1.0
is: http://identifiers.org/pubchem.compound/213144
constant: false
is: SBO:0000247
is: C02862

metaR MI3PP
kinetic law: MODEL1310110042#
is described by: ECO:0000269
type: Reaction
fast: false
reactant: MODEL1310110042#
name: myo-inositol 3-phosphatase
reversible: false
product: MODEL1310110042#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.1.3.25
notes: GENE_ASSOCIATION: (3612.1) or (3613.1) SUBSYSTEM: Inositol phosphate metabolism EC Number: 3.1.3.25 Confidence Level: 4 AUTHORS: PMID:1377913,PMID:2906139,PMID:9322233 NOTES:NCD
modifier: MODEL1310110042#

metaR EX 6dhf LPAREN e RPAREN
kinetic law: MODEL1310110042#
reactant: MODEL1310110042#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: haxglutamyl folate (DHF) exchange
type: Reaction

metaM drib c
is: SBO:0000247
notes: FORMULA: C5H10O4 CHARGE: 0 INCHI: InChI=1S/C5H10O4/c6-2-1-4(8)5(9)3-7/h2,4-5,7-9H,1,3H2/t4-,5+/m0/s1 EHMN_ABBREVIATION: C01801
boundary condition: false
initial concentration: 1.0
name: 2-deoxy-D-ribose
constant: false
is: CHEBI:28816
initial amount: NaN
is: HMDB03224
type: Species
has only substance units: false

metaR G6PDH2c
product: MODEL1310110042#
type: Reaction
reversible: false
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.1.1.49
notes: GENE_ASSOCIATION: (2539.1) SUBSYSTEM: Pentose phosphate pathway EC Number: Confidence Level: 4 AUTHORS: PMID: 4382012, PMID: 13575411, Harpers illustrated Biochemistry (2009) 28th edition pages 174-183 NOTES:found in rats. HMP shunt reactions are cytosolic. Irreversible reaction, coefficient changed to 3
is described by: ECO:0000134
fast: false
modifier: MODEL1310110042#
name: glucose 6-phosphate dehydrogenase
reactant: MODEL1310110042#
kinetic law: MODEL1310110042#

metaR NCNt
product: MODEL1310110042#
is described by: ECO:0000269
modifier: MODEL1310110042#
kinetic law: MODEL1310110042#
type: Reaction
is: SBO:0000185
name: Na+/Ca2+-NH4+ exchange
fast: false
reactant: MODEL1310110042#
reversible: true
notes: GENE_ASSOCIATION: (9187.1) or (25769.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10484410,PMID:10662833,PMID:11294880,PMID:12379639,PMID:14770312,PMID:9478004 NOTES:NCD

metaM tethex3 e
initial amount: NaN
type: Species
is: HMDB02007
initial concentration: 1.0
name: tetracosahexaenoic acid, n-3
notes: FORMULA: C24H35O2 CHARGE: -1 INCHI: InChI=1/C24H36O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-24(25)26/h3-4,6-7,9-10,12-13,15-18H,2,5,8,11,14,19-23H2,1H3,(H,25,26)/b4-3-,7-6-,10-9-,13-12-,16-15-,18-17-
has only substance units: false
constant: false
boundary condition: false
is: SBO:0000247

metaR r0774
is version of: http://identifiers.org/ec-code/1.1.1.35
is described by: ECO:0000000
modifier: MODEL1310110042#
reactant: MODEL1310110042#
reversible: true
fast: false
is: SBO:0000176
product: MODEL1310110042#
name: Uroporphyrinogen I carboxy-lyase Porphyrin and chlorophyll metabolism EC:4.1.1.37
kinetic law: MODEL1310110042#
is version of: http://identifiers.org/ec-code/4.2.1.107
type: Reaction
is version of: http://identifiers.org/ec-code/4.2.1.17
notes: GENE_ASSOCIATION: (1962.1) or (3033.1) or (3030.1) or (3028.1) or (3295.1) SUBSYSTEM: Unassigned EC Number: 4.1.1.37 Confidence Level: 0 AUTHORS: PMID:17360334 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110042#_c569c44f_6e8b_4c3f_bbaa_57f6ff825f8d
boundary condition: true
has only substance units: false
constant: false
is: Q59F77
type: Species
is encoded by: hsa:5330
initial concentration: NaN
is: SBO:0000252
name: PLCB2
initial amount: NaN

metaM ocdcea e
has only substance units: false
boundary condition: false
notes: FORMULA: C18H33O2 CHARGE: -1
initial concentration: 1.0
type: Species
is: HMDB00207
is: C00712
initial amount: NaN
is: CHEBI:0
constant: false
is: SBO:0000247
name: octadecenoate (n-C18:1)

http://identifiers.org/biomodels.db/MODEL1310110042#_8b236a2d_3aa3_4f53_bed0_3938a87ce3ec
type: Species
has only substance units: false
boundary condition: true
is: SBO:0000252
initial concentration: NaN
is encoded by: hsa:51102
is: Q9BV79
name: MECR
constant: false
initial amount: NaN

metaM ptdcacrn c
initial concentration: 1.0
boundary condition: false
is: SBO:0000247
type: Species
initial amount: NaN
is: CHEBI:18303
name: pendtadenoyl carnitine
constant: false
notes: FORMULA: C22H43NO4 CHARGE: 0 INCHI: InChI=1/C22H43NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-22(26)27-20(18-21(24)25)19-23(2,3)4/h20H,5-19H2,1-4H3/t20-/m0/s1
has only substance units: false

metaR GCALDD
kinetic law: MODEL1310110042#
is version of: http://identifiers.org/ec-code/1.2.1.3
reactant: MODEL1310110042#
reversible: false
notes: GENE_ASSOCIATION: (218.1) or (223.1) or (8854.2) or (224.1) or (222.1) or (8854.1) or (221.1) or (216.1) or (8854.3) or (501.1) or (220.1) SUBSYSTEM: Glyoxylate and dicarboxylate metabolism EC Number: 1.2.1.21 Confidence Level: 2 AUTHORS: PMID:11434452 NOTES:JLR
product: MODEL1310110042#
is version of: http://identifiers.org/ec-code/1.2.1.5
fast: false
type: Reaction
name: Glycolaldehyde dehydrogenase
is version of: http://identifiers.org/ec-code/1.2.1.36
is: SBO:0000176
is described by: ECO:0000304
modifier: MODEL1310110042#

metaR G14T12g
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.4.1.22
kinetic law: MODEL1310110042#
notes: GENE_ASSOCIATION: (8703.1) or (2683.1) or (8704.2) or (8704.1) or (9334.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.38 Confidence Level: 4 AUTHORS: PMID:12512857,PMID:1903938,PMID:3094506,PMID:3144273,PMID:9405390,PMID:9435216 NOTES:Keratan sulfate I biosynthesis NCD
type: Reaction
is described by: ECO:0000000
product: MODEL1310110042#
fast: false
reactant: MODEL1310110042#
modifier: MODEL1310110042#
is version of: http://identifiers.org/ec-code/2.4.1.90
name: beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase, Golgi
is version of: http://identifiers.org/ec-code/2.4.1.38
reversible: false

metaM but c
type: Species
is: SBO:0000247
notes: FORMULA: C4H7O2 CHARGE: -1 INCHI: InChI=1S/C4H8O2/c1-2-3-4(5)6/h2-3H2,1H3,(H,5,6)/p-1 HEPATONET_1.0_ABBREVIATION: HC00223 EHMN_ABBREVIATION: C00246
constant: false
boundary condition: false
is: HMDB00039
is: CHEBI:17968
has only substance units: false
initial amount: NaN
name: butyrate
initial concentration: 1.0

metaM ksi pre5 g
notes: FORMULA: C101H164N7O75SX CHARGE: -2
constant: false
initial amount: NaN
type: Species
is: SBO:0000247
boundary condition: false
initial concentration: 1.0
is: CHEBI:28067
name: keratan sulfate I biosynthesis, precursor 5
has only substance units: false

metaM crm hs r
is: SBO:0000247
constant: false
boundary condition: false
initial amount: NaN
is: CHEBI:52639
type: Species
notes: FORMULA: C18H36NO2FULLRCO CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC01990 EHMN_ABBREVIATION: C00195
initial concentration: 1.0
name: N-acylsphingosine
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110042#_7dbae501_6a43_44a5_a039_2fc36e12ee65
is: SBO:0000252
boundary condition: true
initial concentration: NaN
name: GLRX
is encoded by: hsa:2745
type: Species
constant: false
has only substance units: false
is: P35754
initial amount: NaN

metaM tethex3coa x
is: C16168
is: http://identifiers.org/pubchem.compound/47205478
is: SBO:0000247
notes: FORMULA: C45H66N7O17P3S CHARGE: -4 INCHI: InChI=1/C45H70N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-24-25-36(54)73-29-28-47-35(53)26-27-48-43(57)40(56)45(2,3)31-66-72(63,64)69-71(61,62)65-30-34-39(68-70(58,59)60)38(55)44(67-34)52-33-51-37-41(46)49-32-50-42(37)52/h5-6,8-9,11-12,14-15,17-18,20-21,32-34,38-40,44,55-56H,4,7,10,13,16,19,22-31H2,1-3H3,(H,47,53)(H,48,57)(H,61,62)(H,63,64)(H2,46,49,50)(H2,58,59,60)/b6-5-,9-8-,12-11-,15-14-,18-17-,21-20-/t34-,38?,39-,40+,44-/m1/s1
initial concentration: 1.0
constant: false
boundary condition: false
name: tetracosahexaenoyl coenzyme A
has only substance units: false
type: Species
initial amount: NaN
is: HMDB06243

metaR FAOXC12DCx
kinetic law: MODEL1310110042#
product: MODEL1310110042#
reactant: MODEL1310110042#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: production of dodecanedioyl carnitine
type: Reaction

metaR 3HBCDm
name: 3-hydroxybutyryl-CoA dehydratase, mitochondrial
fast: false
modifier: MODEL1310110042#
kinetic law: MODEL1310110042#
type: Reaction
notes: GENE_ASSOCIATION: (55268.1) SUBSYSTEM: Butanoate metabolism EC Number: 4.2.1.55 Confidence Level: 2 AUTHORS: PMID:9073515 NOTES:NCD. rat gene that is homologous to the human gene encodes for this activity
is: SBO:0000176
product: MODEL1310110042#
is described by: ECO:0000254
reversible: true
reactant: MODEL1310110042#

metaM arach c
has only substance units: false
type: Species
notes: FORMULA: C20H39O2 CHARGE: -1 INCHI: InChI=1S/C20H40O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20(21)22/h2-19H2,1H3,(H,21,22)/p-1 EHMN_ABBREVIATION: CE0102
name: arachidate
initial concentration: 1.0
boundary condition: false
constant: false
is: SBO:0000247
is: CHEBI:32360
initial amount: NaN
is: HMDB02212

metaM cdpdag hs c
has only substance units: false
is: CHEBI:58332
boundary condition: false
initial amount: NaN
notes: FORMULA: C12H17N3O11P2FULLRCO2FULLR2CO2 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC02078
type: Species
initial concentration: 1.0
constant: false
name: CDP-diacylglycerol(2-)
is: SBO:0000247

metaR DNDPt18m
is described by: ECO:0000269
kinetic law: MODEL1310110042#
reversible: false
reactant: MODEL1310110042#
fast: false
notes: GENE_ASSOCIATION: (60386.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:11226231 NOTES:IT
is: SBO:0000185
type: Reaction
name: dUDP transport via ADP antiport
product: MODEL1310110042#
modifier: MODEL1310110042#

metaM 3m4hpga c
notes: FORMULA: C9H10O4 CHARGE: 0 INCHI: InChI=1/C9H10O4/c1-13-9-4-6(8(12)5-10)2-3-7(9)11/h2-5,8,11-12H,1H3 HEPATONET_1.0_ABBREVIATION: HC01520 EHMN_ABBREVIATION: C05583
name: 3-Methoxy-4-hydroxyphenylglycolaldehyde
has only substance units: false
constant: false
is: C05583
type: Species
is: SBO:0000247
is: http://identifiers.org/pubchem.compound/7909
is: HMDB04061
boundary condition: false
initial concentration: 1.0
initial amount: NaN

metaR OCT11EFATP
kinetic law: MODEL1310110042#
product: MODEL1310110042#
reactant: MODEL1310110042#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: uptake of vaccenic acid by cells
type: Reaction

metaR r2109
product: MODEL1310110042#
reactant: MODEL1310110042#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
modifier: MODEL1310110042#
kinetic law: MODEL1310110042#
type: Reaction
is: SBO:0000185
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
fast: false
reversible: true
is described by: ECO:0000000

metaR ITCOALm
product: MODEL1310110042#
is version of: http://identifiers.org/ec-code/6.2.1.4
is: SBO:0000176
modifier: MODEL1310110042#
kinetic law: MODEL1310110042#
reactant: MODEL1310110042#
type: Reaction
is version of: http://identifiers.org/ec-code/6.2.1.5
fast: false
name: Itaconate--CoA ligase (ADP-forming), mitochondrial
is described by: ECO:0000212
notes: GENE_ASSOCIATION: (8802.1 and 8803.1) SUBSYSTEM: C5-branched dibasic acid metabolism EC Number: 6.2.1.5 Confidence Level: 1 AUTHORS: PMID:13783048 NOTES:NCD
reversible: true

metaR r0784
notes: GENE_ASSOCIATION: (AA526438.1) or (H17063.1) or (51102.1) or (55825.1) SUBSYSTEM: Pentose phosphate pathway EC Number: 1.1.1.15 Confidence Level: 0 AUTHORS: PMID:13373783 NOTES:
type: Reaction
is described by: ECO:0000000
modifier: MODEL1310110042#
product: MODEL1310110042#
is version of: http://identifiers.org/ec-code/1.3.1.38
reactant: MODEL1310110042#
is: SBO:0000176
fast: false
name: xylitol:NAD oxidoreductase Pentose and glucuronate interconversions EC:1.1.1.15
reversible: true
kinetic law: MODEL1310110042#

metaR r0998
is: SBO:0000185
reactant: MODEL1310110042#
fast: false
name: Facilitated diffusion
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:1735445,PMID:18406340,PMID:1988962,PMID:2351134,PMID:2355017,PMID:6361812,PMID:7892212,PMID:8132483 NOTES:
product: MODEL1310110042#
type: Reaction
reversible: true
kinetic law: MODEL1310110042#

metaR MM6B2g
product: MODEL1310110042#
fast: false
is described by: ECO:0000000
kinetic law: MODEL1310110042#
is: SBO:0000176
modifier: MODEL1310110042#
type: Reaction
reactant: MODEL1310110042#
is version of: http://identifiers.org/ec-code/3.2.1.113
notes: GENE_ASSOCIATION: (4121.1) or (57134.1) or (10905.1) SUBSYSTEM: N-glycan synthesis EC Number: 3.2.1.113 Confidence Level: 0 AUTHORS: PMID:10915796,PMID:9592125 NOTES:NCD
reversible: false
name: mannosyl-oligosaccharide 1,2-alpha-mannosidase, Golgi apparatus

metaM crm hs c
is: SBO:0000247
type: Species
is: CHEBI:52639
initial amount: NaN
name: N-acylsphingosine
has only substance units: false
boundary condition: false
initial concentration: 1.0
constant: false
notes: FORMULA: C18H36NO2FULLRCO CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC01990 EHMN_ABBREVIATION: C00195

metaR DOLPMT1 Uer
modifier: MODEL1310110042#
product: MODEL1310110042#
reactant: MODEL1310110042#
is version of: http://identifiers.org/ec-code/2.4.1.258
is described by: ECO:0000000
kinetic law: MODEL1310110042#
is: SBO:0000176
type: Reaction
name: dolichyl-phosphate-mannose-glycolipid alpha-mannosyltransferase (uterus)
fast: false
notes: GENE_ASSOCIATION: (10195.4) or (10195.1) or (10195.3) or (10195.2) SUBSYSTEM: N-glycan synthesis EC Number: 2.4.1.130 Confidence Level: 0 AUTHORS: NOTES:NCD
reversible: false

metaM 5htrp c
initial concentration: 1.0
name: 5-hydroxy-L-tryptophan
notes: FORMULA: C11H12N2O3 CHARGE: 0 INCHI: InChI=1S/C11H12N2O3/c12-9(11(15)16)3-6-5-13-10-2-1-7(14)4-8(6)10/h1-2,4-5,9,13-14H,3,12H2,(H,15,16)/t9-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00472 EHMN_ABBREVIATION: C00643
type: Species
is: SBO:0000247
initial amount: NaN
boundary condition: false
is: CHEBI:17780
is: HMDB00472
constant: false
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110042#_23bece4b_f76a_452c_b60f_71b5a931b4e7
boundary condition: true
is: SBO:0000252
constant: false
is: Q1ET61
type: Species
is encoded by: hsa:6818
initial amount: NaN
name: SULT1A3
initial concentration: NaN
has only substance units: false

metaR G14T2g
modifier: MODEL1310110042#
notes: GENE_ASSOCIATION: (8703.1) or (2683.1) or (8704.2) or (8704.1) or (9334.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.38 Confidence Level: 4 AUTHORS: PMID:12512857,PMID:1903938,PMID:3094506,PMID:3144273,PMID:9405390,PMID:9435216 NOTES:Keratan sulfate II biosynthesis NCD
name: beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase, Golgi
type: Reaction
is version of: http://identifiers.org/ec-code/2.4.1.38
fast: false
is version of: http://identifiers.org/ec-code/2.4.1.90
reversible: false
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.4.1.22
is described by: ECO:0000000
kinetic law: MODEL1310110042#
reactant: MODEL1310110042#
product: MODEL1310110042#

metaM doldp U r
constant: false
boundary condition: false
initial concentration: 1.0
notes: FORMULA: C1025H1670O70P20 CHARGE: -30 INCHI: InChI=1S/C25H46O7P2/c1-21(2)11-7-12-22(3)13-8-14-23(4)15-9-16-24(5)17-10-18-25(6)19-20-31-34(29,30)32-33(26,27)28/h11,13,15,17,25H,7-10,12,14,16,18-20H2,1-6H3,(H,29,30)(H2,26,27,28)/b22-13+,23-15+,24-17-
initial amount: NaN
name: Dolichol diphosphate, human uterine homolog
is: SBO:0000247
has only substance units: false
type: Species
is: CHEBI:15750

http://identifiers.org/biomodels.db/MODEL1310110042#_5a44bd08_28db_4c5e_9952_b63a42840cde
is: Q9H6R3
is: SBO:0000252
name: ACSS3
has only substance units: false
initial concentration: NaN
type: Species
initial amount: NaN
constant: false
is encoded by: hsa:79611
boundary condition: true

metaR r2108
kinetic law: MODEL1310110042#
reversible: true
is: SBO:0000185
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
fast: false
modifier: MODEL1310110042#
type: Reaction
product: MODEL1310110042#
reactant: MODEL1310110042#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1

metaM Rtotalcoa c
notes: FORMULA: CO2FULLRC21H31N7O15P3S CHARGE: -4
type: Species
boundary condition: false
has only substance units: false
initial concentration: 1.0
name: R total Coenzyme A
is: HMDB01448
constant: false
is: SBO:0000247
initial amount: NaN
is: CHEBI:16189

metaM ala L m
initial amount: NaN
initial concentration: 1.0
type: Species
notes: FORMULA: C3H7NO2 CHARGE: 0 INCHI: InChI=1S/C3H7NO2/c1-2(4)3(5)6/h2H,4H2,1H3,(H,5,6)/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00048
has only substance units: false
name: L-alanine
constant: false
is: CHEBI:16977
is: SBO:0000247
boundary condition: false
is: HMDB00161

metaR ACACT5p
kinetic law: MODEL1310110042#
is: SBO:0000176
reversible: false
notes: GENE_ASSOCIATION: (30.1) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.16 Confidence Level: 4 AUTHORS: PMID:1679347 NOTES:NCD
modifier: MODEL1310110042#
reactant: MODEL1310110042#
name: acetyl-CoA C-acyltransferase (decanoyl-CoA), peroxisomal
type: Reaction
is version of: http://identifiers.org/ec-code/2.3.1.16
fast: false
product: MODEL1310110042#
is described by: ECO:0000269

metaR CRNtim
kinetic law: MODEL1310110042#
is described by: ECO:0000269
is: SBO:0000185
reversible: false
name: L-carnitine transport out of mitochondria via diffusion
reactant: MODEL1310110042#
fast: false
product: MODEL1310110042#
modifier: MODEL1310110042#
notes: GENE_ASSOCIATION: (788.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172 NOTES:NCD
type: Reaction

metaR PPItx
reactant: MODEL1310110042#
is described by: ECO:0000000
product: MODEL1310110042#
type: Reaction
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 1 AUTHORS: NOTES:diffusion NJ
name: Diphosphate transporter, peroxisome
reversible: true
is: SBO:0000185
kinetic law: MODEL1310110042#

http://identifiers.org/biomodels.db/MODEL1310110042#_68407c9a_b74c_4f3f_b2f3_a618165e391e
has only substance units: false
is: SBO:0000252
name: PKLR
constant: false
initial amount: NaN
boundary condition: true
initial concentration: NaN
type: Species
is encoded by: hsa:5313

http://identifiers.org/biomodels.db/MODEL1310110042#_ddcbcd92_feeb_44ce_af9d_ac7d99f34c58
is: P31040
type: Species
initial amount: NaN
is encoded by: hsa:6389
constant: false
name: SDHA
has only substance units: false
initial concentration: NaN
boundary condition: true
is: SBO:0000252

metaM phyt e
type: Species
is: HMDB00801
is: CHEBI:37257
boundary condition: false
has only substance units: false
notes: FORMULA: C20H39O2 CHARGE: -1 INCHI: InChI=1S/C20H40O2/c1-16(2)9-6-10-17(3)11-7-12-18(4)13-8-14-19(5)15-20(21)22/h16-19H,6-15H2,1-5H3,(H,21,22)/p-1 EHMN_ABBREVIATION: C01607
name: phytanate
initial amount: NaN
is: SBO:0000247
initial concentration: 1.0
constant: false

metaR r0999
name: Facilitated diffusion
is described by: ECO:0000000
kinetic law: MODEL1310110042#
reactant: MODEL1310110042#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:1735445,PMID:18406340,PMID:1988962,PMID:2351134,PMID:2355017,PMID:6361812,PMID:7892212,PMID:8132483 NOTES:
product: MODEL1310110042#
is: SBO:0000185
type: Reaction
reversible: true

metaR HMGCOAtm
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: PMID:14713247 NOTES:NCD
type: Reaction
is described by: ECO:0000000
is: SBO:0000185
product: MODEL1310110042#
kinetic law: MODEL1310110042#
reversible: true
name: Hydroxymethylglutaryl-CoA reversible mitochondrial transport
fast: false
reactant: MODEL1310110042#

metaR RE2426C
reactant: MODEL1310110042#
fast: false
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Tryptophan metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:12044950 NOTES:
name: RE2426
kinetic law: MODEL1310110042#
product: MODEL1310110042#
type: Reaction
reversible: true
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110042#_677d7ae2_aea5_449f_9e44_77adaf790949
constant: false
type: Species
has only substance units: false
initial concentration: NaN
name: BAAT
initial amount: NaN
boundary condition: true
is encoded by: hsa:570
is: Q14032
is: SBO:0000252

metaM c226crn c
initial concentration: 1.0
is: SBO:0000247
constant: false
name: cervonyl carnitine
boundary condition: false
is: http://identifiers.org/pubchem.compound/127055
is: HMDB06510
type: Species
initial amount: NaN
notes: FORMULA: C29H45NO4 CHARGE: 0 INCHI: InChI=1/C29H45NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-24-29(33)34-27(25-28(31)32)26-30(2,3)4/h6-7,9-10,12-13,15-16,18-19,21-22,27H,5,8,11,14,17,20,23-26H2,1-4H3/b7-6+,10-9+,13-12+,16-15+,19-18+,22-21+
has only substance units: false

metaM leu L m
name: L-leucine
boundary condition: false
is: SBO:0000247
initial concentration: 1.0
is: HMDB00687
has only substance units: false
type: Species
constant: false
initial amount: NaN
notes: FORMULA: C6H13NO2 CHARGE: 0 INCHI: InChI=1S/C6H13NO2/c1-4(2)3-5(7)6(8)9/h4-5H,3,7H2,1-2H3,(H,8,9)/t5-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00121 EHMN_ABBREVIATION: C00123
is: CHEBI:15603

metaM arach e
type: Species
notes: FORMULA: C20H39O2 CHARGE: -1 INCHI: InChI=1S/C20H40O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20(21)22/h2-19H2,1H3,(H,21,22)/p-1 EHMN_ABBREVIATION: CE0102
has only substance units: false
constant: false
is: SBO:0000247
initial concentration: 1.0
name: arachidate
boundary condition: false
initial amount: NaN
is: CHEBI:32360
is: HMDB02212

metaM cs b deg1 l
is: HMDB00812
initial amount: NaN
boundary condition: false
initial concentration: 1.0
constant: false
name: chondroitin sulfate B / dermatan sulfate (IdoA2S-GalNAc4S), degradation product 1
is: CHEBI:16953
is: SBO:0000247
notes: FORMULA: C45H67N2O46S3 CHARGE: -5
has only substance units: false
type: Species

metaM trdrd c
initial amount: NaN
is: C00342
notes: FORMULA: XH2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00289 EHMN_ABBREVIATION: C00342
has only substance units: false
boundary condition: false
initial concentration: 1.0
name: Reduced thioredoxin
is: SBO:0000247
is: CHEBI:15967
constant: false
type: Species

metaM acrn m
initial concentration: 1.0
is: HMDB00201
is: CHEBI:57589
type: Species
initial amount: NaN
name: O-acetylcarnitine
has only substance units: false
notes: FORMULA: C9H17NO4 CHARGE: 0 INCHI: InChI=1S/C9H17NO4/c1-7(11)14-8(5-9(12)13)6-10(2,3)4/h8H,5-6H2,1-4H3/t8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00966 EHMN_ABBREVIATION: C02571
is: SBO:0000247
boundary condition: false
constant: false

metaR DOLPMT3 Uer
modifier: MODEL1310110042#
reactant: MODEL1310110042#
product: MODEL1310110042#
reversible: false
is described by: ECO:0000000
fast: false
is: SBO:0000176
notes: GENE_ASSOCIATION: (79087.1) SUBSYSTEM: N-glycan synthesis EC Number: 2.4.1.130 Confidence Level: 0 AUTHORS: NOTES:NCD
name: dolichyl-phosphate-mannose-glycolipid alpha-mannosyltransferase (uterus)
is version of: http://identifiers.org/ec-code/2.4.1.260
kinetic law: MODEL1310110042#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110042#_e571d9e5_e91b_4bdc_9aa0_da878541b46f
initial amount: NaN
is encoded by: hsa:8399
has only substance units: false
is: SBO:0000252
constant: false
boundary condition: true
type: Species
initial concentration: NaN
name: PLA2G10
is: O15496

http://identifiers.org/biomodels.db/MODEL1310110042#_3682772d_2efb_428c_b32c_b408b5d48675
is encoded by: hsa:8394
has only substance units: false
type: Species
is: SBO:0000252
initial concentration: NaN
is: Q99755
constant: false
name: PIP5K1A
initial amount: NaN
boundary condition: true

metaR SPODM
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.15.1.1
name: superoxide dismutase
type: Reaction
reversible: false
fast: false
modifier: MODEL1310110042#
notes: GENE_ASSOCIATION: (6647.1) SUBSYSTEM: ROS detoxification EC Number: 1.15.1.1 Confidence Level: 4 AUTHORS: PMID:1332049,PMID:3889846 NOTES:JLR
kinetic law: MODEL1310110042#
product: MODEL1310110042#
is described by: ECO:0000269
reactant: MODEL1310110042#

http://identifiers.org/biomodels.db/MODEL1310110042#_e5f8916f_7a41_41eb_a577_1c3ecf8857df
name: RDH10
is: Q8IZV5
initial amount: NaN
initial concentration: NaN
boundary condition: true
type: Species
is encoded by: hsa:157506
is: SBO:0000252
has only substance units: false
constant: false

metaR C204CRNt
is: SBO:0000185
kinetic law: MODEL1310110042#
name: arachidonic acid transport into the mitochondria
reversible: false
product: MODEL1310110042#
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: PMID:14598172 NOTES:TDV C20:4 transport
reactant: MODEL1310110042#
type: Reaction
is described by: ECO:0000000
fast: false

metaM ksii core4 pre10 g
has only substance units: false
initial amount: NaN
is: CHEBI:28067
constant: false
initial concentration: 1.0
is: SBO:0000247
name: keratan sulfate II biosynthesis, precursor 10
type: Species
boundary condition: false
notes: FORMULA: C89H143N7O69S2X CHARGE: -3

metaR EX C05965 LPAREN e RPAREN
kinetic law: MODEL1310110042#
reactant: MODEL1310110042#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 12(S)-HPETE(1-) exchange
type: Reaction

metaR DPMVDc
modifier: MODEL1310110042#
reactant: MODEL1310110042#
type: Reaction
kinetic law: MODEL1310110042#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/4.1.1.33
is described by: ECO:0000134
fast: false
product: MODEL1310110042#
notes: GENE_ASSOCIATION: (4597.1) SUBSYSTEM: Squalene and cholesterol synthesis EC Number: Confidence Level: 4 AUTHORS: Davidson, N. O., Magun, A. M. and Glickman, R. M. 2011. Enterocyte Lipid Absorption and Secretion. Comprehensive Physiology. 505?526, PMID: 17015489, PMID: 18216769, PMID: 6833883, PMID: 11229876. NOTES:Enterocytes stand next to liver in endogenous cholesterol synthesis. in rats they provide 25% of bodys cholesterol. the crypt epithelial cells synthesize maximum cholesterol when compared to other parts of the GI tract (PMCID: PMC292609). Reactions till farnesyl pyrophosphate operates in cytosol, however, further steps including squalene synthase operates in E.R (Harpers illustrated Biochemistry (2009) 28th edition, Lange medical publications, chapter 26, page 224-227). all the cholesterol synthesis enzymes have also been found in peroxisomes (PMID: 12121718), no evidence for enterocyte sub-cellular sites, so cytosolic reactions have been added according to Harper book. one proton added t product for elemental balancing.
reversible: false
name: diphosphomevalonate decarboxylase, cytosol

metaR r1944
name: Y+LAT2 Utilized transport
reactant: MODEL1310110042#
fast: false
kinetic law: MODEL1310110042#
type: Reaction
is: SBO:0000185
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is described by: ECO:0000000
product: MODEL1310110042#
modifier: MODEL1310110042#
reversible: false

metaM fe2 m
type: Species
initial amount: NaN
initial concentration: 1.0
boundary condition: false
is: SBO:0000247
is: C00023
notes: FORMULA: Fe CHARGE: 2 HEPATONET_1.0_ABBREVIATION: HC01846 EHMN_ABBREVIATION: C00023
constant: false
is: HMDB00692
is: CHEBI:29033
name: Fe2+
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110042#_6dd09236_716e_47fd_bce5_435b4739d7cc
is: SBO:0000252
is: Q9BTU6
has only substance units: false
type: Species
name: PI4K2A
initial amount: NaN
is encoded by: hsa:55361
boundary condition: true
constant: false
initial concentration: NaN

metaR r0422
name: Isocitrate:NADP+ oxidoreductase (decarboxylating) Citrate cycle (TCA cycle) EC:1.1.1.42
is described by: ECO:0000000
kinetic law: MODEL1310110042#
fast: false
product: MODEL1310110042#
modifier: MODEL1310110042#
notes: GENE_ASSOCIATION: (AA081045.1) or (AI620219.1) or (219.1) or (217.1) or (224.1) or (501.1) or (223.1) or (AU149534.1) or (T83654.1) SUBSYSTEM: Unassigned EC Number: 1.1.1.42 Confidence Level: 0 AUTHORS: PMID:10521434,PMID:16489927,PMID:9866202 NOTES:
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.2.1.3
reactant: MODEL1310110042#
reversible: true
type: Reaction

metaR FTHFDH
is version of: http://identifiers.org/ec-code/1.5.1.6
is described by: ECO:0000269
fast: false
type: Reaction
is: SBO:0000176
reversible: false
reactant: MODEL1310110042#
kinetic law: MODEL1310110042#
notes: GENE_ASSOCIATION: (10840.1) SUBSYSTEM: Folate metabolism EC Number: 1.5.1.6 Confidence Level: 4 AUTHORS: PMID:2733692 NOTES:IT
name: formyltetrahydrofolate dehydrogenase
product: MODEL1310110042#
modifier: MODEL1310110042#

http://identifiers.org/biomodels.db/MODEL1310110042#_6e77862e_d360_4f46_b67d_24c7231e7c84
initial amount: NaN
has only substance units: false
constant: false
name: SULT1A3
type: Species
is encoded by: hsa:6818
initial concentration: NaN
is: SBO:0000252
boundary condition: true

metaR r0783
type: Reaction
reactant: MODEL1310110042#
kinetic law: MODEL1310110042#
is described by: ECO:0000000
fast: false
is version of: http://identifiers.org/ec-code/4.2.1.17
is version of: http://identifiers.org/ec-code/1.1.1.35
reversible: true
product: MODEL1310110042#
is: SBO:0000176
name: lanosterol D24-reductase Biosynthesis of steroids EC:1.3.1.72
notes: GENE_ASSOCIATION: (1892.1) or (1962.1) or (3030.1) SUBSYSTEM: Cholesterol metabolism EC Number: 1.3.1.72 Confidence Level: 0 AUTHORS: PMID:7946524 NOTES:
modifier: MODEL1310110042#

metaR r0997
name: COT Facilitated diffusion
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:1735445,PMID:18406340,PMID:1988962,PMID:2351134,PMID:2355017,PMID:6361812,PMID:7892212,PMID:8132483 NOTES:
product: MODEL1310110042#
is described by: ECO:0000000
reversible: false
kinetic law: MODEL1310110042#
type: Reaction
fast: false
is: SBO:0000185
reactant: MODEL1310110042#

metaR HDCAtr
kinetic law: MODEL1310110042#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11788354,PMID:12864740 NOTES:NJ
reversible: true
name: fatty acid transport via diffusion
type: Reaction
fast: false
reactant: MODEL1310110042#
is: SBO:0000185
product: MODEL1310110042#

metaR EX ac LPAREN e RPAREN
kinetic law: MODEL1310110042#
reactant: MODEL1310110042#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Acetate exchange
type: Reaction

metaM tetpent3coa c
initial concentration: 1.0
boundary condition: false
name: tetracosapentaenoyl coenzyme A, n-3
initial amount: NaN
constant: false
type: Species
is: C16167
is: SBO:0000247
has only substance units: false
notes: FORMULA: C45H68N7O17P3S CHARGE: -4 INCHI: InChI=1/C45H72N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-24-25-36(54)73-29-28-47-35(53)26-27-48-43(57)40(56)45(2,3)31-66-72(63,64)69-71(61,62)65-30-34-39(68-70(58,59)60)38(55)44(67-34)52-33-51-37-41(46)49-32-50-42(37)52/h5-6,8-9,11-12,14-15,17-18,32-34,38-40,44,55-56H,4,7,10,13,16,19-31H2,1-3H3,(H,47,53)(H,48,57)(H,61,62)(H,63,64)(H2,46,49,50)(H2,58,59,60)/b6-5-,9-8-,12-11-,15-14-,18-17-/t34-,38-,39-,40?,44-/m1/s1

http://identifiers.org/biomodels.db/MODEL1310110042#_428bb00f_2388_4f5a_bc62_e426209bb387
is encoded by: hsa:9856
constant: false
has only substance units: false
is: F5H123
name: DYLX2
boundary condition: true
is: SBO:0000252
initial concentration: NaN
type: Species
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110042#_23bea628_44bb_4f4c_be00_9ba05ed53c47
initial concentration: NaN
boundary condition: true
initial amount: NaN
type: Species
has only substance units: false
is: SBO:0000252
is encoded by: hsa:6487
name: ST3GAL3
constant: false

metaM phyt c
type: Species
constant: false
is: CHEBI:37257
is: HMDB00801
has only substance units: false
notes: FORMULA: C20H39O2 CHARGE: -1 INCHI: InChI=1S/C20H40O2/c1-16(2)9-6-10-17(3)11-7-12-18(4)13-8-14-19(5)15-20(21)22/h16-19H,6-15H2,1-5H3,(H,21,22)/p-1 EHMN_ABBREVIATION: C01607
boundary condition: false
name: phytanate
initial amount: NaN
initial concentration: 1.0
is: SBO:0000247

metaR EX cspg b LPAREN e RPAREN
kinetic law: MODEL1310110042#
reactant: MODEL1310110042#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: chondroitin sulfate B / dermatan sulfate (IdoA2S-GalNAc4S) proteoglycan exchange
type: Reaction

metaR C102CPT1
kinetic law: MODEL1310110042#
product: MODEL1310110042#
reactant: MODEL1310110042#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: production of decadienoylcarnitine
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110042#_efe3c416_b5b0_4f2d_b85e_2aa2a65c7b93
name: ACP1
has only substance units: false
is encoded by: hsa:52
constant: false
initial concentration: NaN
is: B5MCC7
is: SBO:0000252
initial amount: NaN
boundary condition: true
type: Species

http://identifiers.org/biomodels.db/MODEL1310110042#_d89de5f3_b844_4dbe_941f_9562a2ba2a49
type: Species
boundary condition: true
has only substance units: false
is encoded by: hsa:9167
is: SBO:0000252
constant: false
initial concentration: NaN
is: Q6FGA0
name: COX7A2L
initial amount: NaN

metaR EX eicostet LPAREN e RPAREN
kinetic law: MODEL1310110042#
reactant: MODEL1310110042#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: eicosatetranoic acid exchange
type: Reaction

metaM dsT antigen g
name: disialyl-T antigen
type: Species
constant: false
is: HMDB01440
is: SBO:0000247
notes: FORMULA: C36H56N3O26X CHARGE: -2
initial concentration: 1.0
boundary condition: false
has only substance units: false
is: CHEBI:16497
initial amount: NaN

metaR r0780
kinetic law: MODEL1310110042#
name: 4,4-dimethyl-5a-cholesta-8,24-dien-3b-ol:NADP+ D14-oxidoreductase Biosynthesis of steroids EC:1.3.1.70
reactant: MODEL1310110042#
fast: false
is described by: ECO:0000000
modifier: MODEL1310110042#
type: Reaction
notes: GENE_ASSOCIATION: (30.1) or (10449.1) or (3032.1) or (4645.1) SUBSYSTEM: Cholesterol metabolism EC Number: 1.3.1.70 Confidence Level: 0 AUTHORS: PMID:11969204,PMID:7946524 NOTES:
reversible: true
is version of: http://identifiers.org/ec-code/2.3.1.16
is: SBO:0000176
product: MODEL1310110042#

metaM ppcoa m
is: HMDB01275
is: C00100
boundary condition: false
initial concentration: 1.0
has only substance units: false
is: CHEBI:57392
notes: FORMULA: C24H36N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00101 EHMN_ABBREVIATION: C00100
name: Propanoyl-CoA
type: Species
initial amount: NaN
is: SBO:0000247
constant: false

metaR TRDRm
is: SBO:0000176
reversible: false
is version of: http://identifiers.org/ec-code/1.8.1.9
fast: false
modifier: MODEL1310110042#
name: thioredoxin reductase (NADPH)
type: Reaction
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (114112.1) or (10587.1) or (10587.3) or (10587.2) SUBSYSTEM: Nucleotide interconversion EC Number: 1.8.1.9 Confidence Level: 4 AUTHORS: PMID:10215850,PMID:11259642,PMID:12705894 NOTES:NCD
kinetic law: MODEL1310110042#
reactant: MODEL1310110042#
product: MODEL1310110042#

metaR H2Ot
product: MODEL1310110042#
is described by: ECO:0000269
reversible: true
type: Reaction
name: H2O transport via diffusion
modifier: MODEL1310110042#
notes: GENE_ASSOCIATION: (6523.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:11024018,PMID:11034615,PMID:12748858,PMID:2490366,PMID:8063771 NOTES:renamed from H20t5 to H2Ot NCD
reactant: MODEL1310110042#
fast: false
is: SBO:0000185
kinetic law: MODEL1310110042#

metaM tolbutamide e
name: tolbutamide
notes: FORMULA: C12H18N2O3S CHARGE: 0 INCHI: InChI=1S/C12H18N2O3S/c1-3-4-9-13-12(15)14-18(16,17)11-7-5-10(2)6-8-11/h5-8H,3-4,9H2,1-2H3,(H2,13,14,15)
initial amount: NaN
is: CHEBI:27999
type: Species
constant: false
is: SBO:0000247
boundary condition: false
has only substance units: false
is: C07148
initial concentration: 1.0

metaM crm hs g
initial concentration: 1.0
constant: false
has only substance units: false
type: Species
notes: FORMULA: C18H36NO2FULLRCO CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC01990 EHMN_ABBREVIATION: C00195
boundary condition: false
is: SBO:0000247
is: CHEBI:52639
name: N-acylsphingosine
initial amount: NaN

metaR VACCCPT2
notes: GENE_ASSOCIATION: (1376.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: NOTES:NJ
fast: false
reversible: false
product: MODEL1310110042#
is: SBO:0000176
reactant: MODEL1310110042#
type: Reaction
kinetic law: MODEL1310110042#
is version of: http://identifiers.org/ec-code/2.3.1.21
is described by: ECO:0000000
modifier: MODEL1310110042#
name: carnitine transferase

http://identifiers.org/biomodels.db/MODEL1310110042#_ce85522f_fa8d_4f5c_ae5a_ddf6c3caef17
has only substance units: false
constant: false
is: SBO:0000252
type: Species
boundary condition: true
name: PGM2
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:55276
is: Q96G03

metaR FAOXC204
type: Reaction
reversible: false
is version of: http://identifiers.org/ec-code/1.3.8.1
is version of: http://identifiers.org/ec-code/1.3.99.3
notes: GENE_ASSOCIATION: (35.1) or (35.1) or (34.1) or (34.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.99.3 Confidence Level: 4 AUTHORS: PMID:2565344,PMID:3035565 NOTES:TV Other enzymes: 1.3.3.6, 4.2.1.74, 4.2.1.17, 1.1.1.35, 1.1.1.211
name: Beta oxidation of long chain fatty acid
is: SBO:0000176
reactant: MODEL1310110042#
product: MODEL1310110042#
fast: false
modifier: MODEL1310110042#
is described by: ECO:0000269
kinetic law: MODEL1310110042#

http://identifiers.org/biomodels.db/MODEL1310110042#_9ab7d217_c521_42b0_9e4d_e1ab44b551b2
boundary condition: true
constant: false
is: SBO:0000252
name: HSD3B2
initial amount: NaN
has only substance units: false
is: P26439
type: Species
is encoded by: hsa:3284
initial concentration: NaN

metaR r2082
kinetic law: MODEL1310110042#
reversible: true
modifier: MODEL1310110042#
product: MODEL1310110042#
reactant: MODEL1310110042#
is described by: ECO:0000000
is: SBO:0000185
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
type: Reaction
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
fast: false

metaR r1177
kinetic law: MODEL1310110042#
is described by: ECO:0000000
type: Reaction
reversible: false
product: MODEL1310110042#
reactant: MODEL1310110042#
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 3.1.1.13 Confidence Level: 0 AUTHORS: PMID:11230747,PMID:8112342 NOTES:
is: SBO:0000176
name: EC:3.1.1.13
fast: false

metaR r0994
reversible: true
product: MODEL1310110042#
is described by: ECO:0000000
kinetic law: MODEL1310110042#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:15975683 NOTES:
type: Reaction
reactant: MODEL1310110042#
fast: false
name: Facilitated diffusion

metaR S6TASE12ly
fast: false
is described by: ECO:0000000
is: SBO:0000176
type: Reaction
modifier: MODEL1310110042#
product: MODEL1310110042#
reversible: true
reactant: MODEL1310110042#
is version of: http://identifiers.org/ec-code/3.1.6.14
name: N-acetylglucosamine-6-sulfatase, lysosomal
notes: GENE_ASSOCIATION: (2799.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.1.6.14 Confidence Level: 4 AUTHORS: PMID:3196333,PMID:3689314,PMID:3689315 NOTES:NCD
kinetic law: MODEL1310110042#

metaR ACONT
reactant: MODEL1310110042#
fast: false
is: SBO:0000176
kinetic law: MODEL1310110042#
product: MODEL1310110042#
is described by: ECO:0000134
modifier: MODEL1310110042#
notes: GENE_ASSOCIATION: (3658.1) or (48.1) SUBSYSTEM: Citric acid cycle EC Number: 4.2.1.3 Confidence Level: 0 AUTHORS: PMID:10419470,PMID:17244191,PMID:17244192 NOTES:SMP. Biochemical
is version of: http://identifiers.org/ec-code/4.2.1.3
type: Reaction
name: aconitase
reversible: true

metaR r0781
modifier: MODEL1310110042#
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/4.2.1.17
product: MODEL1310110042#
type: Reaction
reversible: true
is version of: http://identifiers.org/ec-code/1.1.1.35
kinetic law: MODEL1310110042#
notes: GENE_ASSOCIATION: (1962.1) or (3033.1) or (3030.1) or (3028.1) or (3295.1) SUBSYSTEM: Cholesterol metabolism EC Number: 1.14.13.70 Confidence Level: 0 AUTHORS: PMID:11969204,PMID:7946524 NOTES:
is version of: http://identifiers.org/ec-code/4.2.1.107
is: SBO:0000176
reactant: MODEL1310110042#
fast: false
name: Lanosterol,NADPH:oxygen oxidoreductase (14-methyl cleaving) Biosynthesis of steroids EC:1.14.13.70

metaM forglu c
is: SBO:0000247
is: C00439
notes: FORMULA: C6H8N2O4 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00357 EHMN_ABBREVIATION: C00439
is: CHEBI:18327
initial amount: NaN
is: HMDB00854
has only substance units: false
initial concentration: 1.0
boundary condition: false
name: N-Formimidoyl-L-glutamate
type: Species
constant: false

http://identifiers.org/biomodels.db/MODEL1310110042#_8d6c4c7d_1c8e_4359_83e0_04fe1a68a3bc
boundary condition: true
name: _AA278423_1_m
is: SBO:0000252
initial amount: NaN
has only substance units: false
initial concentration: NaN
type: Species
constant: false
is encoded by: hsa:AA278423

metaM 3ttetddcoa c
constant: false
is: SBO:0000247
is: HMDB02014
name: 3-hydroxy trans5,8tetradecadienoyl coa
boundary condition: false
type: Species
has only substance units: false
initial concentration: 1.0
notes: FORMULA: C35H54N7O18P3S CHARGE: -4
initial amount: NaN

metaR AG13T11g
reversible: false
product: MODEL1310110042#
name: N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase, Golgi apparatus
modifier: MODEL1310110042#
type: Reaction
notes: GENE_ASSOCIATION: (79369.1) or (374907.1) or (11041.1) or (146712.1) or (374907.2) or (93010.1) or (10331.1) or (10678.1) or (10678.2) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.149 Confidence Level: 4 AUTHORS: PMID:10747980,PMID:11042166,PMID:12061784,PMID:12512857,PMID:15560372,PMID:15620693,PMID:9405606 NOTES:NCD
is: SBO:0000176
kinetic law: MODEL1310110042#
is version of: http://identifiers.org/ec-code/2.4.1.149
reactant: MODEL1310110042#
fast: false
is described by: ECO:0000000

metaR RE1534M
fast: false
is version of: http://identifiers.org/ec-code/2.3.1.16
modifier: MODEL1310110042#
name: RE1534
is described by: ECO:0000000
type: Reaction
is version of: http://identifiers.org/ec-code/4.2.1.17
notes: GENE_ASSOCIATION: (10449.1) or (3032.1) or (3030.1) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.16 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:7923814,PMID:9568246,PMID:9920399 NOTES:
is: SBO:0000176
reactant: MODEL1310110042#
product: MODEL1310110042#
kinetic law: MODEL1310110042#
reversible: true

metaM clpnd e
initial amount: NaN
constant: false
is: HMDB06528
is: SBO:0000247
has only substance units: false
type: Species
initial concentration: 1.0
is: CHEBI:53488
boundary condition: false
name: clupanodonic acid
notes: FORMULA: C22H33O2 CHARGE: -1 INCHI: InChI=1S/C22H34O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22(23)24/h3-4,6-7,9-10,12-13,15-16H,2,5,8,11,14,17-21H2,1H3,(H,23,24)/b4-3-,7-6-,10-9-,13-12-,16-15-

metaM tethex3coa c
is: SBO:0000247
initial concentration: 1.0
type: Species
is: HMDB06243
notes: FORMULA: C45H66N7O17P3S CHARGE: -4 INCHI: InChI=1/C45H70N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-24-25-36(54)73-29-28-47-35(53)26-27-48-43(57)40(56)45(2,3)31-66-72(63,64)69-71(61,62)65-30-34-39(68-70(58,59)60)38(55)44(67-34)52-33-51-37-41(46)49-32-50-42(37)52/h5-6,8-9,11-12,14-15,17-18,20-21,32-34,38-40,44,55-56H,4,7,10,13,16,19,22-31H2,1-3H3,(H,47,53)(H,48,57)(H,61,62)(H,63,64)(H2,46,49,50)(H2,58,59,60)/b6-5-,9-8-,12-11-,15-14-,18-17-,21-20-/t34-,38?,39-,40+,44-/m1/s1
is: http://identifiers.org/pubchem.compound/47205478
name: tetracosahexaenoyl coenzyme A
initial amount: NaN
boundary condition: false
has only substance units: false
constant: false
is: C16168

http://identifiers.org/biomodels.db/MODEL1310110042#_48729988_e388_413b_910d_f25bd3a56252
is: O43916
initial concentration: NaN
is encoded by: hsa:8534
is: SBO:0000252
boundary condition: true
type: Species
constant: false
name: CHST1
initial amount: NaN
has only substance units: false

metaR r0995
product: MODEL1310110042#
is: SBO:0000185
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:1735445,PMID:18406340,PMID:1988962,PMID:2351134,PMID:2355017,PMID:6361812,PMID:7892212,PMID:8132483 NOTES:
type: Reaction
kinetic law: MODEL1310110042#
reactant: MODEL1310110042#
fast: false
name: Mitochondrial Carrier (MC) TCDB:2.A.29.8.3
reversible: true

metaR r2081
product: MODEL1310110042#
reactant: MODEL1310110042#
is: SBO:0000185
reversible: true
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
fast: false
modifier: MODEL1310110042#
kinetic law: MODEL1310110042#
is described by: ECO:0000000
type: Reaction

metaM dolmanp L r
constant: false
has only substance units: false
notes: FORMULA: C1140H1868O90P10 CHARGE: -10 INCHI: InChI=1S/C31H55O9P/c1-22(2)11-7-12-23(3)13-8-14-24(4)15-9-16-25(5)17-10-18-26(6)19-20-38-41(36,37)40-31-30(35)29(34)28(33)27(21-32)39-31/h11,13,15,17,26-35H,7-10,12,14,16,18-21H2,1-6H3,(H,36,37)/b23-13+,24-15+,25-17-/t26?,27-,28-,29+,30+,31?/m1/s1
is: SBO:0000247
type: Species
name: Dolichyl phosphate D-mannose, human liver homolog
initial concentration: 1.0
boundary condition: false
is: CHEBI:15809
initial amount: NaN

metaM nadh x
is: HMDB01487
is: http://identifiers.org/pubchem.compound/3306
initial amount: NaN
is: C00004
is: CHEBI:57945
has only substance units: false
type: Species
name: Nicotinamide adenine dinucleotide - reduced
is: SBO:0000247
boundary condition: false
constant: false
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110042#_c75d9253_33de_45c0_a26b_912ef3b842b7
type: Species
initial concentration: NaN
boundary condition: true
is encoded by: hsa:26063
has only substance units: false
name: DECR2
is: SBO:0000252
initial amount: NaN
constant: false
is: Q9NUI1

metaM C02470 c
constant: false
name: Xanthurenic acid
initial amount: NaN
initial concentration: 1.0
is: SBO:0000247
is: C02470
notes: FORMULA: C10H6NO4 CHARGE: -1 INCHI: InChI=1/C10H7NO4/c12-7-3-1-2-5-8(13)4-6(10(14)15)11-9(5)7/h1-4,12H,(H,11,13)(H,14,15) HEPATONET_1.0_ABBREVIATION: HC00945 EHMN_ABBREVIATION: C02470
has only substance units: false
boundary condition: false
type: Species
is: HMDB00881
is: http://identifiers.org/pubchem.compound/5485

http://identifiers.org/biomodels.db/MODEL1310110042#_0ae422eb_0123_4d5f_9bdb_0f9b4b4d5243
constant: false
initial amount: NaN
initial concentration: NaN
is: Q9P212
boundary condition: true
has only substance units: false
name: PLCE1
type: Species
is encoded by: hsa:51196
is: SBO:0000252

metaM 3hdeccoa m
initial amount: NaN
constant: false
type: Species
notes: FORMULA: C37H60N7O18P3S CHARGE: -4
initial concentration: 1.0
boundary condition: false
is: SBO:0000247
has only substance units: false
is: HMDB02288
name: 3-hydroxyhexadecenoylcoa

metaM damp c
initial amount: NaN
initial concentration: 1.0
is: CHEBI:58245
type: Species
is: HMDB00905
notes: FORMULA: C10H12N5O6P CHARGE: -2 INCHI: InChI=1S/C10H14N5O6P/c11-9-8-10(13-3-12-9)15(4-14-8)7-1-5(16)6(21-7)2-20-22(17,18)19/h3-7,16H,1-2H2,(H2,11,12,13)(H2,17,18,19)/p-2/t5-,6+,7+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00304 EHMN_ABBREVIATION: C00360
boundary condition: false
name: dAMP(2-)
has only substance units: false
constant: false
is: SBO:0000247

metaR r0570
reversible: true
type: Reaction
notes: GENE_ASSOCIATION: (10588.1) or (400410.1) SUBSYSTEM: Pentose phosphate pathway EC Number: 5.4.2.7 Confidence Level: 0 AUTHORS: PMID:3023765 NOTES:
name: 2-Deoxy-D-ribose 1-phosphate 1,5-phosphomutase Pentose phosphate pathway EC:5.4.2.7
kinetic law: MODEL1310110042#
product: MODEL1310110042#
is version of: http://identifiers.org/ec-code/6.3.3.2
is described by: ECO:0000000
modifier: MODEL1310110042#
fast: false
is: SBO:0000176
reactant: MODEL1310110042#

metaM 1pyr5c m
type: Species
initial concentration: 1.0
name: 1-Pyrroline-5-carboxylate
is: CHEBI:15893
is: C03912
initial amount: NaN
constant: false
is: HMDB01301
boundary condition: false
has only substance units: false
is: SBO:0000247
notes: FORMULA: C5H6NO2 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC01199 EHMN_ABBREVIATION: C03912

metaM dtdp m
boundary condition: false
constant: false
has only substance units: false
is: C00363
is: HMDB01274
type: Species
is: SBO:0000247
name: dTDP
is: CHEBI:58369
initial concentration: 1.0
notes: FORMULA: C10H13N2O11P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00307 EHMN_ABBREVIATION: C00363
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110042#_5102436e_631f_4555_a4d2_04f86b47beb7
is: Q16795
has only substance units: false
is: SBO:0000252
constant: false
name: NDUFA9
boundary condition: true
is encoded by: hsa:4704
initial concentration: NaN
initial amount: NaN
type: Species

metaR G12MT2 L
product: MODEL1310110042#
type: Reaction
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: N-glycan synthesis EC Number: 2.4.1.131 Confidence Level: 0 AUTHORS: NOTES:
reversible: false
name: Glycolipid 1,2-alpha-D-mannosyltransferase (liver)
kinetic law: MODEL1310110042#
is: SBO:0000176
reactant: MODEL1310110042#
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110042#_91ba4fe0_fb51_4f9a_8382_c8575fb8134c
name: GPX4
initial amount: NaN
constant: false
is encoded by: hsa:2879
is: P36969
initial concentration: NaN
is: SBO:0000252
has only substance units: false
boundary condition: true
type: Species

metaM HC01522 c
name: Gentisate aldehyde
is: CHEBI:28508
notes: FORMULA: C7H6O3 CHARGE: 0 INCHI: InChI=1S/C7H6O3/c8-4-5-3-6(9)1-2-7(5)10/h1-4,9-10H EHMN_ABBREVIATION: C05585
constant: false
initial amount: NaN
type: Species
initial concentration: 1.0
has only substance units: false
is: SBO:0000247
boundary condition: false

metaR r2080
reversible: true
modifier: MODEL1310110042#
product: MODEL1310110042#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
reactant: MODEL1310110042#
is described by: ECO:0000000
is: SBO:0000185
type: Reaction
fast: false
kinetic law: MODEL1310110042#

metaR EICOSTETCRNt
name: transport into the mitochondria (carnitine)
reversible: false
modifier: MODEL1310110042#
is: SBO:0000185
fast: false
is described by: ECO:0000000
reactant: MODEL1310110042#
kinetic law: MODEL1310110042#
notes: GENE_ASSOCIATION: (788.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: NOTES:NJ
type: Reaction
product: MODEL1310110042#

metaM lnlncgcoa c
type: Species
has only substance units: false
notes: FORMULA: C39H60N7O17P3S CHARGE: -4 INCHI: InChI=1S/C39H64N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-30(48)67-23-22-41-29(47)20-21-42-37(51)34(50)39(2,3)25-60-66(57,58)63-65(55,56)59-24-28-33(62-64(52,53)54)32(49)38(61-28)46-27-45-31-35(40)43-26-44-36(31)46/h8-9,11-12,14-15,26-28,32-34,38,49-50H,4-7,10,13,16-25H2,1-3H3,(H,41,47)(H,42,51)(H,55,56)(H,57,58)(H2,40,43,44)(H2,52,53,54)/p-4/b9-8-,12-11-,15-14-/t28-,32-,33-,34+,38-/m1/s1 EHMN_ABBREVIATION: C03035
is: HMDB06368
name: gamma-linolenoyl-CoA(4-)
initial concentration: 1.0
boundary condition: false
is: SBO:0000247
initial amount: NaN
constant: false
is: CHEBI:57363

metaR UDPGLCAter
reversible: true
kinetic law: MODEL1310110042#
modifier: MODEL1310110042#
notes: GENE_ASSOCIATION: (23169.1) SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 4 AUTHORS: PMID:11322953 NOTES:NCD
fast: false
reactant: MODEL1310110042#
product: MODEL1310110042#
type: Reaction
is described by: ECO:0000269
is: SBO:0000185
name: UDPGlcA endoplasmic reticulum transport via UMP antiport

http://identifiers.org/biomodels.db/MODEL1310110042#_a84c5455_f576_4cd4_a243_505b611a9ad3
is: SBO:0000252
initial amount: NaN
name: ISYNA1
type: Species
has only substance units: false
initial concentration: NaN
is encoded by: hsa:51477
boundary condition: true
is: B3KRT1
constant: false

metaM s2l2fn2m2masn e
name: PA6
is: C00255
initial concentration: 1.0
is: HMDB00244
notes: FORMULA: C90H145N6O65X CHARGE: -2
has only substance units: false
boundary condition: false
constant: false
initial amount: NaN
is: SBO:0000247
is: CHEBI:3554
type: Species

metaM cys L e
is: CHEBI:17561
is: SBO:0000247
has only substance units: false
constant: false
type: Species
is: HMDB00574
initial concentration: 1.0
notes: FORMULA: C3H7NO2S CHARGE: 0 INCHI: InChI=1S/C3H7NO2S/c4-2(1-7)3(5)6/h2,7H,1,4H2,(H,5,6)/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00099
initial amount: NaN
boundary condition: false
name: L-cysteine

http://identifiers.org/biomodels.db/MODEL1310110042#_8034f9e7_7d1c_4ae7_9b2c_abe74441f156
has only substance units: false
is: SBO:0000252
is encoded by: hsa:374907
initial amount: NaN
name: B3GNT8
initial concentration: NaN
boundary condition: true
type: Species
constant: false

metaR CSAPASEly
fast: false
is described by: ECO:0000000
reactant: MODEL1310110042#
kinetic law: MODEL1310110042#
reversible: false
name: chondroitin sulfate A proteoglycan protease, lysosome (endosome)
is: SBO:0000176
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Chondroitin sulfate degradation EC Number: Confidence Level: 1 AUTHORS: PMID:8993162 NOTES:Note that this reaction occurs in the endosome during endocytosis, but has been compartmentalized as lysosomal. NCD
product: MODEL1310110042#

metaR G13MT U
kinetic law: MODEL1310110042#
is: SBO:0000176
modifier: MODEL1310110042#
reactant: MODEL1310110042#
type: Reaction
notes: GENE_ASSOCIATION: (85365.1) or (85365.2) SUBSYSTEM: N-glycan synthesis EC Number: 2.4.1.132 Confidence Level: 0 AUTHORS: NOTES:NCD
is described by: ECO:0000000
fast: false
reversible: false
is version of: http://identifiers.org/ec-code/2.4.1.132
name: Glycolipid 1,3-alpha-D-mannosyltransferase (uterus)
product: MODEL1310110042#

metaR r0571
name: (S)-Methylmalonyl-CoA hydrolase Propanoate metabolism EC:3.1.2.17
kinetic law: MODEL1310110042#
type: Reaction
product: MODEL1310110042#
reversible: true
fast: false
reactant: MODEL1310110042#
notes: GENE_ASSOCIATION: (10157.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 3.1.2.17 Confidence Level: 0 AUTHORS: PMID:3071714,PMID:6885824 NOTES:
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/1.5.1.8
modifier: MODEL1310110042#
is: SBO:0000176

metaR PPItr
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: NOTES:diffusion NJ
name: Diphosphate transporter, endoplasmic reticulum
fast: false
kinetic law: MODEL1310110042#
is described by: ECO:0000000
is: SBO:0000185
type: Reaction
product: MODEL1310110042#
reactant: MODEL1310110042#

http://identifiers.org/biomodels.db/MODEL1310110042#_8dbef030_68bf_4f86_bec0_b5c760570839
has only substance units: false
is encoded by: hsa:AI697028
initial amount: NaN
boundary condition: true
name: _AI697028_1_m
is: SBO:0000252
constant: false
type: Species
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110042#_5682909c_1820_4ecb_8121_7dfbf0ec1c3e
is: Q96CA6
initial amount: NaN
has only substance units: false
type: Species
initial concentration: NaN
boundary condition: true
is encoded by: hsa:30
constant: false
is: SBO:0000252
name: ACAA1

http://identifiers.org/biomodels.db/MODEL1310110042#_8fed28fd_12cf_4929_9bc3_5e5a0f7f60e5
has part: O15269
boundary condition: true
type: Species
name: SPTLC1:SPTLC2
is encoded by: hsa:9517
is encoded by: hsa:10558
constant: false
initial concentration: NaN
initial amount: NaN
is: SBO:0000297
has only substance units: false
has part: O15270

metaM clpnd c
initial amount: NaN
has only substance units: false
constant: false
is: HMDB06528
is: SBO:0000247
type: Species
initial concentration: 1.0
boundary condition: false
name: clupanodonic acid
is: CHEBI:53488
notes: FORMULA: C22H33O2 CHARGE: -1 INCHI: InChI=1S/C22H34O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22(23)24/h3-4,6-7,9-10,12-13,15-16H,2,5,8,11,14,17-21H2,1H3,(H,23,24)/b4-3-,7-6-,10-9-,13-12-,16-15-

metaM chsterol r
type: Species
notes: FORMULA: C27H46O CHARGE: 0 INCHI: InChI=1S/C27H46O/c1-18(2)7-6-8-19(3)23-11-12-24-22-10-9-20-17-21(28)13-15-26(20,4)25(22)14-16-27(23,24)5/h9,18-19,21-25,28H,6-8,10-17H2,1-5H3/t19-,21+,22+,23-,24+,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00178 EHMN_ABBREVIATION: C00187
constant: false
is: HMDB00067
initial amount: NaN
initial concentration: 1.0
is: SBO:0000247
boundary condition: false
is: CHEBI:16113
has only substance units: false
name: cholesterol

metaR VACCCPT1
product: MODEL1310110042#
kinetic law: MODEL1310110042#
is version of: http://identifiers.org/ec-code/2.3.1.21
reactant: MODEL1310110042#
notes: GENE_ASSOCIATION: (1375.1) or (1375.3) or (1375.4) or (126129.1) or (1374.1) or (1375.2) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.21 Confidence Level: 4 AUTHORS: NOTES:NJ
is: SBO:0000176
name: carnitine O-palmitoyltransferase
type: Reaction
modifier: MODEL1310110042#
is described by: ECO:0000000
fast: false
reversible: false

metaM lnlc r
initial amount: NaN
boundary condition: false
notes: FORMULA: C18H31O2 CHARGE: -1 INCHI: InChI=1S/C18H32O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20/h6-7,9-10H,2-5,8,11-17H2,1H3,(H,19,20)/p-1/b7-6-,10-9- HEPATONET_1.0_ABBREVIATION: HC00796 EHMN_ABBREVIATION: C01595
initial concentration: 1.0
is: SBO:0000247
type: Species
is: CHEBI:30245
has only substance units: false
name: linoleate
is: HMDB00673
constant: false

metaM dtdp n
type: Species
is: SBO:0000247
boundary condition: false
notes: FORMULA: C10H13N2O11P2 CHARGE: -3 INCHI: InChI=1S/C10H16N2O11P2/c1-5-3-12(10(15)11-9(5)14)8-2-6(13)7(22-8)4-21-25(19,20)23-24(16,17)18/h3,6-8,13H,2,4H2,1H3,(H,19,20)(H,11,14,15)(H2,16,17,18)/p-3/t6-,7+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00307 EHMN_ABBREVIATION: C00363
initial amount: NaN
name: ({[(2R,3S,5R)-3-hydroxy-5-(5-methyl-2,4-dioxo-1,2,3,4-tetrahydropyrimidin-1-yl)oxolan-2-yl]methyl phosphonato}oxy)phosphonate
constant: false
has only substance units: false
is: CHEBI:58369
initial concentration: 1.0
is: HMDB01274

metaR r0885
name: Mitochondrial Carrier (MC) TCDB:2.A.29.2.7
modifier: MODEL1310110042#
kinetic law: MODEL1310110042#
notes: GENE_ASSOCIATION: (AA526438.1) or (H17063.1) or (51102.1) or (55825.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:15845418,PMID:16600197,PMID:9639574 NOTES:
reactant: MODEL1310110042#
is described by: ECO:0000000
is: SBO:0000185
product: MODEL1310110042#
is version of: http://identifiers.org/ec-code/1.3.1.38
fast: false
reversible: true
type: Reaction

metaR SUBERCROT
kinetic law: MODEL1310110042#
product: MODEL1310110042#
reactant: MODEL1310110042#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: production of suberyl carnitine
type: Reaction

metaR r2101
fast: false
is described by: ECO:0000000
kinetic law: MODEL1310110042#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
modifier: MODEL1310110042#
reactant: MODEL1310110042#
product: MODEL1310110042#
is: SBO:0000185
reversible: true
type: Reaction
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:

metaM m4masn g
notes: FORMULA: C46H77N2O35X CHARGE: 0
boundary condition: false
name: (alpha-D-mannosyl)4-beta-D-mannosyl-diacetylchitobiosyl-L-asparagine (protein)
type: Species
is: SBO:0000247
initial concentration: 1.0
initial amount: NaN
has only substance units: false
constant: false
is: C05881

http://identifiers.org/biomodels.db/MODEL1310110042#_f27130c7_dfed_4248_98e2_5e24994f46af
type: Species
has only substance units: false
constant: false
is: SBO:0000252
boundary condition: true
initial concentration: NaN
name: GALNT8
is: Q9NY28
initial amount: NaN
is encoded by: hsa:26290

http://identifiers.org/biomodels.db/MODEL1310110042#_e21eb14e_a006_4959_9d68_7e62ac8f58dc
initial concentration: NaN
name: UEVLD
constant: false
boundary condition: true
is: SBO:0000252
initial amount: NaN
type: Species
is: Q8IX04
has only substance units: false
is encoded by: hsa:55293

http://identifiers.org/biomodels.db/MODEL1310110042#_9c227ee2_9502_47ac_9513_89577d3dbd4f
boundary condition: true
name: MDH1
is: SBO:0000252
initial concentration: NaN
initial amount: NaN
constant: false
is: B7Z3I7
has only substance units: false
is encoded by: hsa:4190
type: Species

metaM HC02023 r
type: Species
name: Cholesterol-ester-ol
is: CHEBI:46898
initial amount: NaN
notes: FORMULA: C45H78O2 CHARGE: 0 INCHI: InChI=1S/C45H78O2/c1-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-25-43(46)47-38-30-32-44(5)37(34-38)26-27-39-41-29-28-40(36(4)24-22-23-35(2)3)45(41,6)33-31-42(39)44/h14-15,26,35-36,38-42H,7-13,16-25,27-34H2,1-6H3/b15-14-/t36-,38+,39+,40-,41+,42+,44+,45-/m1/s1
constant: false
has only substance units: false
initial concentration: 1.0
boundary condition: false
is: SBO:0000247

metaR r0671
name: (R)-4-Phosphopantothenate:L-cysteine ligase EC:6.3.2.5
modifier: MODEL1310110042#
kinetic law: MODEL1310110042#
reactant: MODEL1310110042#
is described by: ECO:0000000
type: Reaction
notes: GENE_ASSOCIATION: (2717.1) or (6173.1) SUBSYSTEM: CoA synthesis EC Number: 6.3.2.5 Confidence Level: 0 AUTHORS: PMID:11923312,PMID:12906824,PMID:15893380 NOTES:
reversible: false
fast: false
is version of: http://identifiers.org/ec-code/3.2.1.22
is: SBO:0000176
product: MODEL1310110042#

metaM utp n
is: HMDB00285
notes: FORMULA: C9H11N2O15P3 CHARGE: -4 INCHI: InChI=1S/C9H15N2O15P3/c12-5-1-2-11(9(15)10-5)8-7(14)6(13)4(24-8)3-23-28(19,20)26-29(21,22)25-27(16,17)18/h1-2,4,6-8,13-14H,3H2,(H,19,20)(H,21,22)(H,10,12,15)(H2,16,17,18)/p-4/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00077 EHMN_ABBREVIATION: C00075
constant: false
boundary condition: false
is: SBO:0000247
initial concentration: 1.0
has only substance units: false
type: Species
initial amount: NaN
is: CHEBI:46398
name: UTP(4-)

metaR EX leu L LPAREN e RPAREN
kinetic law: MODEL1310110042#
reactant: MODEL1310110042#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: L-Leucine exchange
type: Reaction

metaR r0672
product: MODEL1310110042#
fast: false
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.3.1.65
modifier: MODEL1310110042#
type: Reaction
notes: GENE_ASSOCIATION: (570.1) SUBSYSTEM: Bile acid synthesis EC Number: 1.1.1.181 Confidence Level: 0 AUTHORS: PMID:12679481 NOTES:
reactant: MODEL1310110042#
name: Cholest-5-ene-3beta,7alpha-diol:NAD+ 3-oxidoreductase Bile acid biosynthesis EC:1.1.1.181
is described by: ECO:0000000
kinetic law: MODEL1310110042#
reversible: true

metaR r2100
modifier: MODEL1310110042#
reversible: true
kinetic law: MODEL1310110042#
type: Reaction
is described by: ECO:0000000
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
reactant: MODEL1310110042#
product: MODEL1310110042#
is: SBO:0000185
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
fast: false

metaM chsterol l
initial concentration: 1.0
type: Species
has only substance units: false
constant: false
is: SBO:0000247
boundary condition: false
notes: FORMULA: C27H46O CHARGE: 0 INCHI: InChI=1S/C27H46O/c1-18(2)7-6-8-19(3)23-11-12-24-22-10-9-20-17-21(28)13-15-26(20,4)25(22)14-16-27(23,24)5/h9,18-19,21-25,28H,6-8,10-17H2,1-5H3/t19-,21+,22+,23-,24+,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00178 EHMN_ABBREVIATION: C00187
is: HMDB00067
initial amount: NaN
name: cholesterol
is: CHEBI:16113

http://identifiers.org/biomodels.db/MODEL1310110042#_601e2311_aeaf_4db9_8bf5_06cb67caf1ba
initial amount: NaN
type: Species
is encoded by: hsa:AI935189
boundary condition: true
has only substance units: false
name: _AI935189_1_m
is: SBO:0000252
initial concentration: NaN
constant: false

metaM dgtp c
name: dGTP
is: HMDB01440
initial amount: NaN
is: SBO:0000247
boundary condition: false
is: C00286
is: CHEBI:16497
has only substance units: false
constant: false
initial concentration: 1.0
type: Species
notes: FORMULA: C10H12N5O13P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00252 EHMN_ABBREVIATION: C00286

metaM ksi deg38 l
initial concentration: 1.0
notes: FORMULA: C54H91N3O41 CHARGE: 0
type: Species
is: SBO:0000247
boundary condition: false
initial amount: NaN
constant: false
is: CHEBI:12936
is: HMDB00143
name: keratan sulfate I, degradation product 38
has only substance units: false

metaM hexdicoa r
constant: false
has only substance units: false
boundary condition: false
is: SBO:0000247
initial concentration: 1.0
name: hexadecanedioylcoa
is: HMDB00672
type: Species
initial amount: NaN
is: C08260
notes: FORMULA: C37H59N7O19P3S CHARGE: -5

http://identifiers.org/biomodels.db/MODEL1310110042#_2cc916c0_07d2_46ee_8292_52ae290d9d19
initial concentration: NaN
is: Q7GXY8
boundary condition: true
is encoded by: hsa:4512
name: COX1
type: Species
has only substance units: false
constant: false
is: SBO:0000252
initial amount: NaN

metaR ADMDC
reactant: MODEL1310110042#
is described by: ECO:0000269
product: MODEL1310110042#
reversible: false
is version of: http://identifiers.org/ec-code/4.1.1.50
type: Reaction
name: adenosylmethionine decarboxylase
fast: false
modifier: MODEL1310110042#
is: SBO:0000176
notes: GENE_ASSOCIATION: (262.1) SUBSYSTEM: Arginine and Proline Metabolism EC Number: 4.1.1.50 Confidence Level: 4 AUTHORS: PMID:2460457 NOTES:
kinetic law: MODEL1310110042#

metaR ARAB Lt
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:12359133,PMID:15234337,PMID:2167807 NOTES:
kinetic law: MODEL1310110042#
product: MODEL1310110042#
is described by: ECO:0000000
is: SBO:0000185
fast: false
type: Reaction
reactant: MODEL1310110042#
name: L-arabinoase extracellular transport

metaM acrn x
is: CHEBI:57589
is: SBO:0000247
type: Species
boundary condition: false
is: HMDB00201
initial amount: NaN
notes: FORMULA: C9H17NO4 CHARGE: 0 INCHI: InChI=1S/C9H17NO4/c1-7(11)14-8(5-9(12)13)6-10(2,3)4/h8H,5-6H2,1-4H3/t8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00966 EHMN_ABBREVIATION: C02571
constant: false
name: O-acetylcarnitine
has only substance units: false
initial concentration: 1.0

metaR DGTPtn
name: dGTP diffusion in nucleus
reversible: true
fast: false
type: Reaction
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: NOTES:IT
reactant: MODEL1310110042#
product: MODEL1310110042#
is described by: ECO:0000000
kinetic law: MODEL1310110042#

metaM cys L c
is: SBO:0000247
name: L-cysteine
initial concentration: 1.0
boundary condition: false
constant: false
initial amount: NaN
has only substance units: false
is: HMDB00574
type: Species
notes: FORMULA: C3H7NO2S CHARGE: 0 INCHI: InChI=1S/C3H7NO2S/c4-2(1-7)3(5)6/h2,7H,1,4H2,(H,5,6)/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00099
is: CHEBI:17561

metaR CYSO
is version of: http://identifiers.org/ec-code/1.13.11.20
notes: GENE_ASSOCIATION: (1036.1) SUBSYSTEM: Taurine and hypotaurine metabolism EC Number: 1.13.11.20 Confidence Level: 4 AUTHORS: PMID:14514920 NOTES:IT
reactant: MODEL1310110042#
kinetic law: MODEL1310110042#
name: cysteine oxidase
is: SBO:0000176
reversible: false
fast: false
type: Reaction
is described by: ECO:0000269
modifier: MODEL1310110042#
product: MODEL1310110042#

metaM tdec4ecoa m
is: HMDB00792
name: trans4decenoylcoa
type: Species
initial amount: NaN
boundary condition: false
is: C08277
constant: false
initial concentration: 1.0
has only substance units: false
notes: FORMULA: C31H48N7O17P3S CHARGE: -4
is: SBO:0000247

metaM arachdcrn c
name: C20:4 carnitine
initial concentration: 1.0
notes: FORMULA: C27H45NO4 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC12236
boundary condition: false
has only substance units: false
is: CHEBI:57387
constant: false
is: SBO:0000247
is: HMDB01322
type: Species
initial amount: NaN

metaR EX tststerone LPAREN e RPAREN
kinetic law: MODEL1310110042#
reactant: MODEL1310110042#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Testosterone exchange
type: Reaction

metaR SCP2x
fast: false
is described by: ECO:0000269
modifier: MODEL1310110042#
is version of: http://identifiers.org/ec-code/2.3.1.176
kinetic law: MODEL1310110042#
type: Reaction
reversible: false
name: peroxisomal thiolase 2
product: MODEL1310110042#
is: SBO:0000176
reactant: MODEL1310110042#
notes: GENE_ASSOCIATION: (6342.1) SUBSYSTEM: Bile acid synthesis EC Number: Confidence Level: 4 AUTHORS: PMID:1703300 NOTES:SCP has two transcripts, second isoform specific to peroxisomes, first is specific for cyt and mit need to double check stoichiometry - reaction cofactors (additional coa + release of prop coa) from BM (Roche) Biochemical Pathways version 2 analog added as per KEGG NJ

metaM chsterol m
name: cholesterol
has only substance units: false
notes: FORMULA: C27H46O CHARGE: 0 INCHI: InChI=1S/C27H46O/c1-18(2)7-6-8-19(3)23-11-12-24-22-10-9-20-17-21(28)13-15-26(20,4)25(22)14-16-27(23,24)5/h9,18-19,21-25,28H,6-8,10-17H2,1-5H3/t19-,21+,22+,23-,24+,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00178 EHMN_ABBREVIATION: C00187
is: HMDB00067
is: CHEBI:16113
initial amount: NaN
initial concentration: 1.0
type: Species
boundary condition: false
constant: false
is: SBO:0000247

metaR ITPtn
fast: false
kinetic law: MODEL1310110042#
reversible: true
reactant: MODEL1310110042#
type: Reaction
product: MODEL1310110042#
is: SBO:0000185
is described by: ECO:0000000
name: ITP nuclear transport
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: NOTES:IT

metaR DESAT18 6
reactant: MODEL1310110042#
product: MODEL1310110042#
name: fatty acyl-CoA desaturase (n-C18:1CoA -> n-C18:2CoA)
kinetic law: MODEL1310110042#
is described by: ECO:0000269
is: SBO:0000176
reversible: false
notes: GENE_ASSOCIATION: (9415.1) SUBSYSTEM: Fatty acid synthesis EC Number: 1.14.99.25 Confidence Level: 4 AUTHORS: NOTES:for homo sapiens, noted to actually be NADH-cyt b5, using NADH at present NJ
fast: false
modifier: MODEL1310110042#
type: Reaction

metaR EX CE4723 LPAREN e RPAREN
kinetic law: MODEL1310110042#
reactant: MODEL1310110042#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: neocasomorphin (1-5) exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110042#_e8f06432_ae4b_41b4_93b4_1ba88770da83
name: SULT1A1
is encoded by: hsa:6817
constant: false
is: SBO:0000252
initial amount: NaN
has only substance units: false
boundary condition: true
initial concentration: NaN
type: Species

http://identifiers.org/biomodels.db/MODEL1310110042#_6547b470_0e0b_4f48_a58c_209fdbfa4e21
has only substance units: false
is: E9PB82
is: SBO:0000252
constant: false
name: HSD17B4
boundary condition: true
initial amount: NaN
initial concentration: NaN
type: Species
is encoded by: hsa:3295

metaR GLUt2m
product: MODEL1310110042#
is described by: ECO:0000269
fast: false
kinetic law: MODEL1310110042#
notes: GENE_ASSOCIATION: (83733.1) or (8604.1) or (79751.1) or (10165.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172 NOTES:NCD
type: Reaction
name: L-glutamate reversible transport via proton symport, mitochondrial
reactant: MODEL1310110042#
reversible: true
modifier: MODEL1310110042#
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110042#_3fbe86df_5198_40bb_bc34_fd4b80466df6
name: _AA203143_1_c
is encoded by: hsa:AA203143
is: SBO:0000252
constant: false
boundary condition: true
initial concentration: NaN
has only substance units: false
type: Species
initial amount: NaN

metaM tolbutamide c
boundary condition: false
name: tolbutamide
notes: FORMULA: C12H18N2O3S CHARGE: 0 INCHI: InChI=1S/C12H18N2O3S/c1-3-4-9-13-12(15)14-18(16,17)11-7-5-10(2)6-8-11/h5-8H,3-4,9H2,1-2H3,(H2,13,14,15)
is: SBO:0000247
initial concentration: 1.0
is: CHEBI:27999
constant: false
type: Species
is: C07148
has only substance units: false
initial amount: NaN

metaR r2103
reversible: true
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
kinetic law: MODEL1310110042#
type: Reaction
is: SBO:0000185
fast: false
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
modifier: MODEL1310110042#
reactant: MODEL1310110042#
product: MODEL1310110042#
is described by: ECO:0000000

metaM nadh m
is: http://identifiers.org/pubchem.compound/3306
initial amount: NaN
name: Nicotinamide adenine dinucleotide - reduced
is: CHEBI:57945
is: HMDB01487
type: Species
initial concentration: 1.0
has only substance units: false
constant: false
is: C00004
is: SBO:0000247
boundary condition: false

metaM CE5120 m
is: CHEBI:57923
constant: false
is: SBO:0000247
notes: FORMULA: C35H54N7O17P3S CHARGE: -4 INCHI: InChI=1/C35H58N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-26(44)63-19-18-37-25(43)16-17-38-33(47)30(46)35(2,3)21-56-62(53,54)59-61(51,52)55-20-24-29(58-60(48,49)50)28(45)34(57-24)42-23-41-27-31(36)39-22-40-32(27)42/h8-9,14-15,22-24,28-30,34,45-46H,4-7,10-13,16-21H2,1-3H3,(H,37,43)(H,38,47)(H,51,52)(H,53,54)(H2,36,39,40)(H2,48,49,50)/p-4/b9-8-,15-14+/t24-,28+,29+,30u,34-/m0/s1 EHMN_ABBREVIATION: CE5120
has only substance units: false
type: Species
initial amount: NaN
initial concentration: 1.0
boundary condition: false
name: trans-2-cis-8-tetradecadienoyl-CoA

metaR C14OHc
kinetic law: MODEL1310110042#
product: MODEL1310110042#
reactant: MODEL1310110042#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: production of 3-hydroxytetradecanoylcarnitine
type: Reaction

metaR RE3269C
notes: GENE_ASSOCIATION: (8897.1) or (8897.3) or (8897.2) SUBSYSTEM: Phosphatidylinositol phosphate metabolism EC Number: 3.1.3.66 Confidence Level: 0 AUTHORS: PMID:7556092 NOTES:Recin 1 had irreversible version - PI35P3P - GPR from PI35P3P was added - May 2011 IT
reversible: true
type: Reaction
product: MODEL1310110042#
fast: false
reactant: MODEL1310110042#
kinetic law: MODEL1310110042#
modifier: MODEL1310110042#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.1.3.48
name: RE3269
is described by: ECO:0000000

metaR DESAT18 4
kinetic law: MODEL1310110042#
modifier: MODEL1310110042#
notes: GENE_ASSOCIATION: (6319.1) SUBSYSTEM: Fatty acid synthesis EC Number: 1.14.19.1 Confidence Level: 4 AUTHORS: PMID:14967823 NOTES:for homo sapiens, noted to actually be NADH-cyt b5, using NADH at present NJ
product: MODEL1310110042#
is: SBO:0000176
fast: false
type: Reaction
is version of: http://identifiers.org/ec-code/1.14.19.1
reactant: MODEL1310110042#
is described by: ECO:0000000
reversible: false
name: stearoyl-CoA desaturase (n-C18:0CoA -> n-C18:1CoA)

metaM HC02206 e
is: SBO:0000247
boundary condition: false
name: prostaglandin C1(1-)
initial concentration: 1.0
has only substance units: false
initial amount: NaN
notes: FORMULA: C20H31O4 CHARGE: -1 INCHI: InChI=1S/C20H32O4/c1-2-3-6-9-17(21)14-12-16-13-15-19(22)18(16)10-7-4-5-8-11-20(23)24/h12-14,17-18,21H,2-11,15H2,1H3,(H,23,24)/p-1/b14-12+/t17-,18+/m0/s1 EHMN_ABBREVIATION: C04686
constant: false
is: CHEBI:57399
type: Species

http://identifiers.org/biomodels.db/MODEL1310110042#_1ca1898a_ac8b_40ca_8442_5be97eeb3274
has only substance units: false
is: SBO:0000252
name: PAH
constant: false
initial amount: NaN
is encoded by: hsa:5053
is: P00439
boundary condition: true
type: Species
initial concentration: NaN

metaR NS26T2g
reactant: MODEL1310110042#
name: alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase
fast: false
is: SBO:0000176
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (55808.1) SUBSYSTEM: O-glycan synthesis EC Number: 2.4.99.3 Confidence Level: 0 AUTHORS: PMID:10536037 NOTES:NCD
type: Reaction
product: MODEL1310110042#
kinetic law: MODEL1310110042#
is version of: http://identifiers.org/ec-code/2.4.99.3
reversible: false
modifier: MODEL1310110042#

metaM gar c
has only substance units: false
is: SBO:0000247
type: Species
constant: false
initial concentration: 1.0
is: C03838
is: HMDB02022
name: N1-(5-Phospho-D-ribosyl)glycinamide
is: CHEBI:58457
initial amount: NaN
notes: FORMULA: C7H14N2O8P CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC01190 EHMN_ABBREVIATION: C03838
boundary condition: false

metaR r0575
product: MODEL1310110042#
modifier: MODEL1310110042#
kinetic law: MODEL1310110042#
notes: GENE_ASSOCIATION: (AA021081.1) or (AI440329.1) or (R06874.1) or (83549.1) or (7371.1) or (54963.1) SUBSYSTEM: Cholesterol metabolism EC Number: 2.5.1.21 Confidence Level: 0 AUTHORS: PMID:10449533,PMID:1527001,PMID:7864626,PMID:8509416 NOTES:
is described by: ECO:0000000
reversible: true
reactant: MODEL1310110042#
is version of: http://identifiers.org/ec-code/2.7.1.48
name: Presqualene diphosphate:farnesyl-diphosphate farnesyltransferase Biosynthesis of steroids EC:2.5.1.21
is: SBO:0000176
type: Reaction
fast: false

metaR r2102
modifier: MODEL1310110042#
is: SBO:0000185
is described by: ECO:0000000
fast: false
reversible: true
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
reactant: MODEL1310110042#
product: MODEL1310110042#
type: Reaction
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
kinetic law: MODEL1310110042#

metaR EX csn LPAREN e RPAREN
kinetic law: MODEL1310110042#
reactant: MODEL1310110042#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Cytosine exchange
type: Reaction

metaR BILIRUBtr
name: lipid, flip-flop intracellular transport
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: NOTES:cholesterol precursor, transport by "diffusion" -> actually beleived to be flip-flop mechanism (PMID: 12840657). NJ
reactant: MODEL1310110042#
is: SBO:0000185
product: MODEL1310110042#
reversible: true
fast: false
type: Reaction
is described by: ECO:0000000
kinetic law: MODEL1310110042#

http://identifiers.org/biomodels.db/MODEL1310110042#_c7105b33_9b4d_4c2d_bcb0_ce34d89a22ab
initial amount: NaN
name: DGKG
initial concentration: NaN
has only substance units: false
is: P49619
constant: false
is encoded by: hsa:1608
type: Species
is: SBO:0000252
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110042#_f7cb4030_02ac_47cf_b7f3_d9a793d8a71a
name: ACOT2
constant: false
initial amount: NaN
type: Species
is: SBO:0000252
is encoded by: hsa:10965
initial concentration: NaN
boundary condition: true
has only substance units: false
is: P49753

metaR FAOXC226205x
type: Reaction
kinetic law: MODEL1310110042#
is version of: http://identifiers.org/ec-code/1.3.3.6
modifier: MODEL1310110042#
is version of: http://identifiers.org/ec-code/4.2.1.107
reversible: false
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (3295.1 and 30.1 and 51.2) or (51.1 and 3295.1 and 30.1) or (30.1 and 51.2 and 1962.1) or (51.1 and 30.1 and 1962.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.74 Confidence Level: 4 AUTHORS: NOTES:_1 round of beta-oxidation, loses degree of desat, so no fad - in peroxisome, no fad, 1ste set of beta-ox is by acyl-coa oxidase (passes electrons directly to o2 -> h2o2) peroxisomal (very long chain FA) c22:6,n-3 -> c20:5, n-3 4 step FAO lumped also includes EC 1.1.1.35, 1.1.1.211, 1.3.3.6, 4.2.1.17, 4.2.1.74 NJ
product: MODEL1310110042#
is version of: http://identifiers.org/ec-code/1.1.1.35
is version of: http://identifiers.org/ec-code/2.3.1.16
reactant: MODEL1310110042#
name: Beta oxidation of long chain fatty acid
is: SBO:0000176
fast: false

metaM lcts g
initial amount: NaN
is: SBO:0000247
name: lactose
is: CHEBI:17716
constant: false
is: HMDB00186
has only substance units: false
notes: FORMULA: C12H22O11 CHARGE: 0 INCHI: InChI=1S/C12H22O11/c13-1-3-5(15)6(16)9(19)12(22-3)23-10-4(2-14)21-11(20)8(18)7(10)17/h3-20H,1-2H2/t3-,4-,5+,6+,7-,8-,9-,10-,11?,12+/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00220 EHMN_ABBREVIATION: C00243
type: Species
boundary condition: false
initial concentration: 1.0

metaR r2105
is described by: ECO:0000000
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
kinetic law: MODEL1310110042#
reversible: true
product: MODEL1310110042#
is: SBO:0000185
fast: false
type: Reaction
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
modifier: MODEL1310110042#
reactant: MODEL1310110042#

metaR EX dad 2 LPAREN e RPAREN
kinetic law: MODEL1310110042#
reactant: MODEL1310110042#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for 2-deoxyadenosine
type: Reaction

metaM 3ttetddcoa m
notes: FORMULA: C35H54N7O18P3S CHARGE: -4
initial concentration: 1.0
boundary condition: false
name: 3-hydroxy trans5,8tetradecadienoyl coa
type: Species
is: HMDB02014
is: SBO:0000247
initial amount: NaN
constant: false
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110042#_42f3c88e_c30f_412c_8c3f_f31ecbedc8a0
type: Species
boundary condition: true
name: SLC6A14
has only substance units: false
is encoded by: hsa:11254
initial concentration: NaN
constant: false
is: Q9UN76
initial amount: NaN
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110042#_3ffbc93e_8f5d_41d6_afb7_e1f37acac280
has only substance units: false
is: B7Z1F5
constant: false
boundary condition: true
initial concentration: NaN
type: Species
is encoded by: hsa:1558
initial amount: NaN
name: CYP2C8
is: SBO:0000252

metaR RETI1
product: MODEL1310110042#
name: retinol isomerase (11-cis)
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Vitamin A metabolism EC Number: 5.2.1.7 Confidence Level: 2 AUTHORS: PMID:1503811 NOTES:IT
fast: false
reactant: MODEL1310110042#
is: SBO:0000176
is described by: ECO:0000000
type: Reaction
kinetic law: MODEL1310110042#

metaM pail345p hs c
has only substance units: false
boundary condition: false
is: CHEBI:57836
is: SBO:0000247
name: 1-phosphatidyl-1D-myo-inositol 3,4,5-trisphosphate(7-)
notes: FORMULA: C9H13O18P4FULLRCO2FULLR2CO2 CHARGE: -7 EHMN_ABBREVIATION: C05981
type: Species
initial concentration: 1.0
constant: false
initial amount: NaN

metaR sink tetdece1coa LPAREN c RPAREN
kinetic law: MODEL1310110042#
reactant: MODEL1310110042#
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: TETDECE1COASINK
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110042#_ab91e760_236f_4598_ad9c_3f5db92323dc
constant: false
initial amount: NaN
has only substance units: false
initial concentration: NaN
is encoded by: hsa:AI697028
is: SBO:0000252
name: _AI697028_1_e
boundary condition: true
type: Species

http://identifiers.org/biomodels.db/MODEL1310110042#_c5eef3b5_daf8_4a63_8836_c2f7a19d69b8
constant: false
is: Q9HAY6
type: Species
name: BCMO1
is: SBO:0000252
is encoded by: hsa:53630
boundary condition: true
has only substance units: false
initial concentration: NaN
initial amount: NaN

metaR GLYtm
type: Reaction
is described by: ECO:0000000
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:7388024 NOTES:TDV Biochim Biophys Acta. 1980 Jun 6;598(3):588-94
kinetic law: MODEL1310110042#
name: glycine passive transport to mitochondria
fast: false
reversible: true
reactant: MODEL1310110042#
product: MODEL1310110042#

metaM HC02206 c
initial concentration: 1.0
notes: FORMULA: C20H31O4 CHARGE: -1 INCHI: InChI=1S/C20H32O4/c1-2-3-6-9-17(21)14-12-16-13-15-19(22)18(16)10-7-4-5-8-11-20(23)24/h12-14,17-18,21H,2-11,15H2,1H3,(H,23,24)/p-1/b14-12+/t17-,18+/m0/s1 EHMN_ABBREVIATION: C04686
name: prostaglandin C1(1-)
boundary condition: false
is: CHEBI:57399
constant: false
is: SBO:0000247
type: Species
has only substance units: false
initial amount: NaN

metaR APAT2rm
name: 3-Aminopropanoate:2-oxoglutarate aminotransferase (m)
reversible: true
type: Reaction
modifier: MODEL1310110042#
is version of: http://identifiers.org/ec-code/2.6.1.19
kinetic law: MODEL1310110042#
is: SBO:0000176
notes: GENE_ASSOCIATION: (18.1) or (18.2) SUBSYSTEM: beta-Alanine metabolism EC Number: 2.6.19.4 Confidence Level: 1 AUTHORS: PMID:15304357 NOTES:SAB
fast: false
reactant: MODEL1310110042#
is described by: ECO:0000212
product: MODEL1310110042#

metaR RE1845X
reactant: MODEL1310110042#
type: Reaction
notes: GENE_ASSOCIATION: (570.1) SUBSYSTEM: Bile acid synthesis EC Number: 2.3.1.65 Confidence Level: 0 AUTHORS: PMID:11980911 NOTES:IT - removed 1 h[c] from compEHMN reaction as they were not necessary
is described by: ECO:0000000
reversible: true
modifier: MODEL1310110042#
product: MODEL1310110042#
is version of: http://identifiers.org/ec-code/2.3.1.65
fast: false
name: RE1845
is: SBO:0000176
kinetic law: MODEL1310110042#

metaR EX imp LPAREN e RPAREN
kinetic law: MODEL1310110042#
reactant: MODEL1310110042#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: IMP exchange
type: Reaction

metaR RE3628M
is: SBO:0000176
notes: GENE_ASSOCIATION: (1632.1) or (10455.1) or (1962.1) SUBSYSTEM: Fatty acid oxidation EC Number: 5.3.3.8 Confidence Level: 0 AUTHORS: PMID:11356164,PMID:7775433 NOTES:
reactant: MODEL1310110042#
type: Reaction
modifier: MODEL1310110042#
name: RE3628
is version of: http://identifiers.org/ec-code/5.3.3.8
is version of: http://identifiers.org/ec-code/1.1.1.35
fast: false
reversible: true
kinetic law: MODEL1310110042#
product: MODEL1310110042#
is described by: ECO:0000000

metaR r2104
modifier: MODEL1310110042#
is: SBO:0000185
fast: false
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
reversible: true
reactant: MODEL1310110042#
type: Reaction
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
kinetic law: MODEL1310110042#
product: MODEL1310110042#

metaM txa2 r
initial concentration: 1.0
initial amount: NaN
type: Species
constant: false
boundary condition: false
is: HMDB01452
is: SBO:0000247
is: CHEBI:57445
name: thromboxane A2(1-)
notes: FORMULA: C20H31O5 CHARGE: -1 INCHI: InChI=1S/C20H32O5/c1-2-3-6-9-15(21)12-13-17-16(18-14-20(24-17)25-18)10-7-4-5-8-11-19(22)23/h4,7,12-13,15-18,20-21H,2-3,5-6,8-11,14H2,1H3,(H,22,23)/p-1/b7-4-,13-12+/t15-,16+,17+,18-,20+/m0/s1 EHMN_ABBREVIATION: C02198
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110042#_762cb221_0859_450b_b070_3d0362028da1
type: Species
is: SBO:0000252
has only substance units: false
name: ABAT
initial concentration: NaN
boundary condition: true
constant: false
is encoded by: hsa:18
initial amount: NaN

metaM ump r
constant: false
is: SBO:0000247
has only substance units: false
initial concentration: 1.0
is: CHEBI:57865
notes: FORMULA: C9H11N2O9P CHARGE: -2 INCHI: InChI=1S/C9H13N2O9P/c12-5-1-2-11(9(15)10-5)8-7(14)6(13)4(20-8)3-19-21(16,17)18/h1-2,4,6-8,13-14H,3H2,(H,10,12,15)(H2,16,17,18)/p-2/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00105 EHMN_ABBREVIATION: C00105
initial amount: NaN
boundary condition: false
type: Species
is: HMDB00288
name: UMP

metaR HSAT2ly
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Heparan sulfate degradation EC Number: 2.3.1.78 Confidence Level: 4 AUTHORS: PMID:15591281,PMID:8993162 NOTES:The proton is located in the lysosome since it comes from oxidation of the NH3+ group in glucosamine. This reaction assumes that the other proton liberated from glucosamine reduces coa in the cytosol. NCD
reversible: false
name: heparan-glucosaminide N-acetyltransferase, lysosomal
type: Reaction
fast: false
product: MODEL1310110042#
kinetic law: MODEL1310110042#
reactant: MODEL1310110042#
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110042#_29dc960c_a92a_4b2c_8467_3ede684eaf55
has only substance units: false
name: _BE966236_1_m
boundary condition: true
initial amount: NaN
constant: false
type: Species
is: SBO:0000252
initial concentration: NaN
is encoded by: hsa:BE966236

metaR S6TASE20ly
fast: false
notes: GENE_ASSOCIATION: (2799.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.1.6.14 Confidence Level: 4 AUTHORS: PMID:3196333,PMID:3689314,PMID:3689315 NOTES:NCD
name: N-acetylglucosamine-6-sulfatase, lysosomal
kinetic law: MODEL1310110042#
reactant: MODEL1310110042#
is described by: ECO:0000000
type: Reaction
modifier: MODEL1310110042#
product: MODEL1310110042#
is version of: http://identifiers.org/ec-code/3.1.6.14
reversible: true
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110042#_896db3ce_c34a_464a_9d99_5cf2e86b588c
is: SBO:0000252
constant: false
initial amount: NaN
boundary condition: true
name: ALDH1A3
has only substance units: false
is: P47895
initial concentration: NaN
is encoded by: hsa:220
type: Species

http://identifiers.org/biomodels.db/MODEL1310110042#_df6aac99_ea01_4c64_a03a_e41cfd1c6d26
is encoded by: hsa:29906
type: Species
is: O15466
initial amount: NaN
boundary condition: true
name: ST8SIA5
is: SBO:0000252
has only substance units: false
initial concentration: NaN
constant: false

http://identifiers.org/biomodels.db/MODEL1310110042#_13cf7d1b_cda1_4af0_9b11_0d903fba694e
has only substance units: false
boundary condition: true
initial concentration: NaN
constant: false
is encoded by: hsa:79087
type: Species
is: Q9BV10
initial amount: NaN
is: SBO:0000252
name: ALG12

http://identifiers.org/biomodels.db/MODEL1310110042#_71754bc3_c28d_449d_95f5_1140fb7312a1
initial amount: NaN
is: P78542
type: Species
has only substance units: false
initial concentration: NaN
is encoded by: hsa:3098
boundary condition: true
is: SBO:0000252
constant: false
name: HK1

metaM ppcoa x
is: SBO:0000247
constant: false
name: Propanoyl-CoA
is: CHEBI:57392
type: Species
initial concentration: 1.0
has only substance units: false
is: HMDB01275
initial amount: NaN
notes: FORMULA: C24H36N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00101 EHMN_ABBREVIATION: C00100
boundary condition: false
is: C00100

metaR LINKDEG4ly
reversible: false
product: MODEL1310110042#
is described by: ECO:0000000
reactant: MODEL1310110042#
fast: false
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Chondroitin sulfate degradation EC Number: Confidence Level: 2 AUTHORS: PMID:8993162 NOTES:NCD
is: SBO:0000176
kinetic law: MODEL1310110042#
name: degradation of proteoglycan linkage region, lysosomal

metaR EX malttr LPAREN e RPAREN
kinetic law: MODEL1310110042#
reactant: MODEL1310110042#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Maltotriose exchange
type: Reaction

metaR EX cspg a LPAREN e RPAREN
kinetic law: MODEL1310110042#
reactant: MODEL1310110042#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: chondroitin sulfate A (GalNAc4S-GlcA) proteoglycan exchange
type: Reaction

metaR FAOXC61x
kinetic law: MODEL1310110042#
product: MODEL1310110042#
reactant: MODEL1310110042#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: isomerization(C6:1)x
type: Reaction

metaR SUCD1m
is described by: ECO:0000134
name: succinate dehydrogenase
reactant: MODEL1310110042#
type: Reaction
product: MODEL1310110042#
is version of: http://identifiers.org/ec-code/1.3.5.1
modifier: MODEL1310110042#
reversible: true
notes: GENE_ASSOCIATION: (6389.1 and 6392.1 and 6391.1 and 6390.1) SUBSYSTEM: Citric acid cycle EC Number: 1.3.99.1 Confidence Level: 0 AUTHORS: PMID:6945861 NOTES:NCD. Biochemical, Genetic
is: SBO:0000176
kinetic law: MODEL1310110042#
fast: false

http://identifiers.org/biomodels.db/MODEL1310110042#_cd8c10d0_93ed_434b_aca6_3856efeed3f6
has only substance units: false
is: B7Z5G2
is encoded by: hsa:2629
initial amount: NaN
initial concentration: NaN
constant: false
boundary condition: true
name: GBA
is: SBO:0000252
type: Species

metaM lcts e
is: SBO:0000247
constant: false
is: C00243
is: HMDB00186
initial amount: NaN
boundary condition: false
is: CHEBI:17716
name: Lactose
type: Species
notes: FORMULA: C12H22O11 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00220 EHMN_ABBREVIATION: C00243
initial concentration: 1.0
has only substance units: false

metaM ksii core2 deg7 l
boundary condition: false
name: keratan sulfate II (core 2-linked), degradation product 7
is: HMDB00812
is: CHEBI:16953
initial amount: NaN
has only substance units: false
constant: false
notes: FORMULA: C44H73N4O30X CHARGE: 0
type: Species
initial concentration: 1.0
is: SBO:0000247

metaR r2107
is: SBO:0000185
reactant: MODEL1310110042#
product: MODEL1310110042#
type: Reaction
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
reversible: true
is described by: ECO:0000000
fast: false
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
modifier: MODEL1310110042#
kinetic law: MODEL1310110042#

metaR NACHEX3ly
name: beta-N-acetylhexosaminidase, lysosomal
modifier: MODEL1310110042#
reversible: false
type: Reaction
is version of: http://identifiers.org/ec-code/3.2.1.52
is described by: ECO:0000000
is: SBO:0000176
product: MODEL1310110042#
reactant: MODEL1310110042#
fast: false
kinetic law: MODEL1310110042#
notes: GENE_ASSOCIATION: (3073.1) or (3073.1 and 3074.1) or (3074.1) SUBSYSTEM: Chondroitin sulfate degradation EC Number: 3.2.1.52 Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12706724,PMID:8993162 NOTES:NCD

metaM thcholstoic m
boundary condition: false
type: Species
is: HMDB03873
is: CHEBI:18402
initial concentration: 1.0
is: SBO:0000247
initial amount: NaN
has only substance units: false
constant: false
notes: FORMULA: C27H45O5 CHARGE: -1 INCHI: InChI=1S/C27H46O5/c1-15(6-5-7-16(2)25(31)32)19-8-9-20-24-21(14-23(30)27(19,20)4)26(3)11-10-18(28)12-17(26)13-22(24)29/h15-24,28-30H,5-14H2,1-4H3,(H,31,32)/t15-,16?,17+,18-,19-,20+,21+,22-,23+,24+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01340 EHMN_ABBREVIATION: C04722
name: 3alpha,7alpha,12alpha-Trihydroxy-5beta-cholestanoate

http://identifiers.org/biomodels.db/MODEL1310110042#_bf3ae54f_6302_4851_87e9_b9d3a472912c
has only substance units: false
name: GK2
is: SBO:0000252
initial amount: NaN
initial concentration: NaN
boundary condition: true
type: Species
is encoded by: hsa:2712
is: Q14410
constant: false

http://identifiers.org/biomodels.db/MODEL1310110042#_0076a4ce_b38a_49c6_969d_12a1969999d8
is: Q8NFF2
is: SBO:0000252
type: Species
is encoded by: hsa:123041
boundary condition: true
constant: false
initial amount: NaN
has only substance units: false
initial concentration: NaN
name: SLC24A4

http://identifiers.org/biomodels.db/MODEL1310110042#_cbba3217_d561_40cf_bd70_a5b7afcd9796
is encoded by: hsa:84720
initial amount: NaN
has part: Q07326
has only substance units: false
is: SBO:0000297
has part: Q8TEQ8
is encoded by: hsa:5281
initial concentration: NaN
name: PIGF:PIGO
boundary condition: true
constant: false
type: Species

metaR r0578
reversible: true
modifier: MODEL1310110042#
kinetic law: MODEL1310110042#
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/4.1.2.27
reactant: MODEL1310110042#
notes: GENE_ASSOCIATION: (8879.1) SUBSYSTEM: CoA synthesis EC Number: 2.7.1.33 Confidence Level: 0 AUTHORS: PMID:13163064,PMID:15105273,PMID:15659606 NOTES:
is: SBO:0000176
fast: false
type: Reaction
product: MODEL1310110042#
name: ATP:pantothenate 4-phosphotransferase Pantothenate and CoA biosynthesis EC:2.7.1.33

metaM ocde9ecoa x
initial concentration: 1.0
type: Species
initial amount: NaN
boundary condition: false
constant: false
name: 9-octadecenoylcoa
notes: FORMULA: C39H64N7O17P3S CHARGE: -4
is: SBO:0000247
is: http://identifiers.org/pubchem.compound/5280355
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110042#_13eb69aa_f2c2_4864_91a5_246fe45c34ea
has only substance units: false
initial amount: NaN
is encoded by: hsa:8818
initial concentration: NaN
boundary condition: true
type: Species
name: DPM2
constant: false
is: SBO:0000252

metaM eitetcoa m
initial amount: NaN
is: SBO:0000247
notes: FORMULA: C41H62N7O17P3S CHARGE: -4
constant: false
initial concentration: 1.0
boundary condition: false
is: http://identifiers.org/pubchem.compound/24892790
name: 5,8,11,14-eicosatetraenoylcoa
has only substance units: false
type: Species

metaR G12MT2 U
reversible: false
type: Reaction
kinetic law: MODEL1310110042#
reactant: MODEL1310110042#
product: MODEL1310110042#
notes: GENE_ASSOCIATION: SUBSYSTEM: N-glycan synthesis EC Number: 2.4.1.131 Confidence Level: 0 AUTHORS: NOTES:
is: SBO:0000176
name: Glycolipid 1,2-alpha-D-mannosyltransferase (uterus)
is described by: ECO:0000000
fast: false

metaM dgtp e
initial concentration: 1.0
name: dGTP
is: HMDB01440
notes: FORMULA: C10H12N5O13P3 CHARGE: -4 INCHI: InChI=1S/C10H16N5O13P3/c11-10-13-8-7(9(17)14-10)12-3-15(8)6-1-4(16)5(26-6)2-25-30(21,22)28-31(23,24)27-29(18,19)20/h3-6,16H,1-2H2,(H,21,22)(H,23,24)(H2,18,19,20)(H3,11,13,14,17)/t4-,5+,6+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00252 EHMN_ABBREVIATION: C00286
is: CHEBI:16497
is: SBO:0000247
type: Species
constant: false
boundary condition: false
has only substance units: false
initial amount: NaN

metaM nadh r
is: HMDB01487
name: NADH(2-)
initial amount: NaN
initial concentration: 1.0
type: Species
constant: false
has only substance units: false
is: CHEBI:57945
is: SBO:0000247
notes: FORMULA: C21H27N7O14P2 CHARGE: -2 INCHI: InChI=1S/C21H29N7O14P2/c22-17-12-19(25-7-24-17)28(8-26-12)21-16(32)14(30)11(41-21)6-39-44(36,37)42-43(34,35)38-5-10-13(29)15(31)20(40-10)27-3-1-2-9(4-27)18(23)33/h1,3-4,7-8,10-11,13-16,20-21,29-32H,2,5-6H2,(H2,23,33)(H,34,35)(H,36,37)(H2,22,24,25)/p-2/t10-,11-,13-,14-,15-,16-,20-,21-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00014 EHMN_ABBREVIATION: C00004
boundary condition: false

metaR HMGCOAtx
product: MODEL1310110042#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: PMID:14713247 NOTES:diffusion NJ
is described by: ECO:0000000
is: SBO:0000185
name: Hydroxymethylglutaryl-CoA reversible peroxisomal transport
reactant: MODEL1310110042#
reversible: true
type: Reaction
kinetic law: MODEL1310110042#
fast: false

metaM nadp x
name: Nicotinamide adenine dinucleotide phosphate
is: HMDB00217
initial concentration: 1.0
is: CHEBI:58349
type: Species
constant: false
is: C00006
is: SBO:0000247
has only substance units: false
notes: FORMULA: C21H25N7O17P3 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00016 EHMN_ABBREVIATION: C00006
boundary condition: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110042#_2d4b7a20_fbc6_4d9d_9678_fd784c3b55f7
name: EHHADH
type: Species
is: Q9NY65
boundary condition: true
has only substance units: false
is encoded by: hsa:1962
constant: false
initial concentration: NaN
is: SBO:0000252
initial amount: NaN

metaR TETDEC2CRNe
kinetic law: MODEL1310110042#
product: MODEL1310110042#
reactant: MODEL1310110042#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: trnasport of tetradecadienoyl carnitine into extra cellular space
type: Reaction

metaM acrn r
notes: FORMULA: C9H17NO4 CHARGE: 0 INCHI: InChI=1S/C9H17NO4/c1-7(11)14-8(5-9(12)13)6-10(2,3)4/h8H,5-6H2,1-4H3/t8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00966 EHMN_ABBREVIATION: C02571
initial amount: NaN
constant: false
is: CHEBI:57589
has only substance units: false
is: SBO:0000247
name: O-acetylcarnitine
initial concentration: 1.0
boundary condition: false
type: Species
is: HMDB00201

metaR r2106
product: MODEL1310110042#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
reversible: true
is described by: ECO:0000000
modifier: MODEL1310110042#
fast: false
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
type: Reaction
kinetic law: MODEL1310110042#
is: SBO:0000185
reactant: MODEL1310110042#

http://identifiers.org/biomodels.db/MODEL1310110042#_ae05e78b_f88a_4908_a8ce_9ebe4789b2bc
is encoded by: hsa:478
initial amount: NaN
constant: false
name: ATP1A3
boundary condition: true
is: B7Z2T0
initial concentration: NaN
is: SBO:0000252
type: Species
has only substance units: false

metaR TDCHOLAte
type: Reaction
is: SBO:0000185
reactant: MODEL1310110042#
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:unknown mechanism, however bile acids need to be secreted out of the cell NJ
fast: false
name: bile acid intracellular transport
kinetic law: MODEL1310110042#
product: MODEL1310110042#
is described by: ECO:0000000

metaR FACOAL1822
product: MODEL1310110042#
kinetic law: MODEL1310110042#
is: SBO:0000176
type: Reaction
fast: false
notes: GENE_ASSOCIATION: (2180.1) SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 4 AUTHORS: PMID:15292367 NOTES:NJ
reversible: true
modifier: MODEL1310110042#
is version of: http://identifiers.org/ec-code/6.2.1.3
is described by: ECO:0000269
name: fatty-acid--CoA ligase
reactant: MODEL1310110042#

http://identifiers.org/biomodels.db/MODEL1310110042#_47a9ceea_87c1_449e_9762_5396a06a9cac
constant: false
name: SULT2A1
initial concentration: NaN
is: SBO:0000252
type: Species
initial amount: NaN
has only substance units: false
is encoded by: hsa:6822
boundary condition: true
is: Q06520

metaR r0579
reactant: MODEL1310110042#
kinetic law: MODEL1310110042#
notes: GENE_ASSOCIATION: (84890.1) or (AV713053.1) SUBSYSTEM: CoA synthesis EC Number: 2.7.1.33 Confidence Level: 0 AUTHORS: PMID:13163064,PMID:15105273,PMID:15659606 NOTES:
fast: false
reversible: true
modifier: MODEL1310110042#
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/1.13.11.19
product: MODEL1310110042#
name: ATP:pantothenate 4-phosphotransferase Pantothenate and CoA biosynthesis EC:2.7.1.33
is: SBO:0000176
type: Reaction

metaM retn r
initial amount: NaN
is: CHEBI:35291
boundary condition: false
has only substance units: false
initial concentration: 1.0
type: Species
is: SBO:0000247
constant: false
name: all-trans-retinoate
notes: FORMULA: C20H27O2 CHARGE: -1 INCHI: InChI=1S/C20H28O2/c1-15(8-6-9-16(2)14-19(21)22)11-12-18-17(3)10-7-13-20(18,4)5/h6,8-9,11-12,14H,7,10,13H2,1-5H3,(H,21,22)/p-1/b9-6+,12-11+,15-8+,16-14+ HEPATONET_1.0_ABBREVIATION: HC00532 EHMN_ABBREVIATION: C00777
is: HMDB01852

http://identifiers.org/biomodels.db/MODEL1310110042#_2a0a294b_7dc9_4ff9_b1a9_780a8f4fac64
has only substance units: false
is: SBO:0000252
is encoded by: hsa:84720
initial concentration: NaN
name: PIGO
type: Species
is: Q8TEQ8
initial amount: NaN
boundary condition: true
constant: false

metaM cholcoads x
is: HMDB06889
initial concentration: 1.0
name: 3alpha,7alpha,12alpha-Trihydroxy-5beta-cholest-24-enoyl-CoA
is: SBO:0000247
is: CHEBI:27505
has only substance units: false
boundary condition: false
initial amount: NaN
type: Species
constant: false
notes: FORMULA: C48H74N7O20P3S CHARGE: -4 INCHI: InChI=1S/C48H78N7O20P3S/c1-25(29-10-11-30-36-31(20-34(58)48(29,30)6)47(5)14-12-28(56)18-27(47)19-32(36)57)8-7-9-26(2)45(63)79-17-16-50-35(59)13-15-51-43(62)40(61)46(3,4)22-72-78(69,70)75-77(67,68)71-21-33-39(74-76(64,65)66)38(60)44(73-33)55-24-54-37-41(49)52-23-53-42(37)55/h9,23-25,27-34,36,38-40,44,56-58,60-61H,7-8,10-22H2,1-6H3,(H,50,59)(H,51,62)(H,67,68)(H,69,70)(H2,49,52,53)(H2,64,65,66)/t25-,27+,28-,29-,30+,31+,32-,33-,34+,36+,38-,39-,40+,44-,47+,48-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01466 EHMN_ABBREVIATION: C05460

metaR TAXOLte
kinetic law: MODEL1310110042#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:unknown mechanism, related cyp P450 metabolism reactions NJ
product: MODEL1310110042#
type: Reaction
reactant: MODEL1310110042#
fast: false
reversible: true
is described by: ECO:0000000
name: xenobiotic transport

metaR CYTK5
type: Reaction
reversible: true
product: MODEL1310110042#
name: cytidylate kinase (dCMP)
is version of: http://identifiers.org/ec-code/2.7.4.14
fast: false
is: SBO:0000176
kinetic law: MODEL1310110042#
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
reactant: MODEL1310110042#
modifier: MODEL1310110042#

metaM cdp n
initial amount: NaN
boundary condition: false
has only substance units: false
name: CDP(3-)
constant: false
initial concentration: 1.0
type: Species
is: CHEBI:58069
is: SBO:0000247
is: HMDB01546
notes: FORMULA: C9H12N3O11P2 CHARGE: -3 INCHI: InChI=1S/C9H15N3O11P2/c10-5-1-2-12(9(15)11-5)8-7(14)6(13)4(22-8)3-21-25(19,20)23-24(16,17)18/h1-2,4,6-8,13-14H,3H2,(H,19,20)(H2,10,11,15)(H2,16,17,18)/p-3/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00110 EHMN_ABBREVIATION: C00112

metaR EX 3hexdcrn
kinetic law: MODEL1310110042#
reactant: MODEL1310110042#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for 3-hydroxyhexadecanoyl carnitine
type: Reaction

metaM succ c
has only substance units: false
is: CHEBI:30031
is: C00042
initial concentration: 1.0
type: Species
boundary condition: false
is: SBO:0000247
initial amount: NaN
name: Succinate
is: HMDB00254
constant: false
notes: FORMULA: C4H4O4 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00049 EHMN_ABBREVIATION: C00042

metaM fgam c
boundary condition: false
has only substance units: false
initial concentration: 1.0
notes: FORMULA: C8H13N2O9P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC01281 EHMN_ABBREVIATION: C04376
is: CHEBI:58426
is: C04376
is: SBO:0000247
is: HMDB01308
type: Species
name: N2-Formyl-N1-(5-phospho-D-ribosyl)glycinamide
constant: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110042#_e006b3fc_d0f3_4d2c_a037_1f9e35f423a0
is encoded by: hsa:219
name: ALDH1B1
is: SBO:0000252
has only substance units: false
is: P30837
initial concentration: NaN
initial amount: NaN
type: Species
constant: false
boundary condition: true

metaM arachdcoa x
has only substance units: false
type: Species
name: arachidonoyl-CoA(4-)
boundary condition: false
constant: false
is: SBO:0000247
is: CHEBI:57368
initial amount: NaN
is: HMDB06523
initial concentration: 1.0
notes: FORMULA: C41H62N7O17P3S CHARGE: -4 INCHI: InChI=1S/C41H66N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-32(50)69-25-24-43-31(49)22-23-44-39(53)36(52)41(2,3)27-62-68(59,60)65-67(57,58)61-26-30-35(64-66(54,55)56)34(51)40(63-30)48-29-47-33-37(42)45-28-46-38(33)48/h8-9,11-12,14-15,17-18,28-30,34-36,40,51-52H,4-7,10,13,16,19-27H2,1-3H3,(H,43,49)(H,44,53)(H,57,58)(H,59,60)(H2,42,45,46)(H2,54,55,56)/p-4/b9-8-,12-11-,15-14-,18-17-/t30-,34-,35-,36+,40-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01986 EHMN_ABBREVIATION: C02249

http://identifiers.org/biomodels.db/MODEL1310110042#_7b20ad91_b183_4db0_a38b_544e768724ba
is: SBO:0000252
initial concentration: NaN
name: SLC8A3
boundary condition: true
is encoded by: hsa:6547
type: Species
initial amount: NaN
constant: false
has only substance units: false

metaM CE5117 m
initial concentration: 1.0
boundary condition: false
notes: FORMULA: C35H52N7O17P3S CHARGE: -4 INCHI: InChI=1/C35H56N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-26(44)63-19-18-37-25(43)16-17-38-33(47)30(46)35(2,3)21-56-62(53,54)59-61(51,52)55-20-24-29(58-60(48,49)50)28(45)34(57-24)42-23-41-27-31(36)39-22-40-32(27)42/h8-9,11-14,22-24,28-30,34,45-46H,4-7,10,15-21H2,1-3H3,(H,37,43)(H,38,47)(H,51,52)(H,53,54)(H2,36,39,40)(H2,48,49,50)/p-4/b9-8-,12-11-,14-13+/t24-,28+,29+,30u,34-/m0/s1 EHMN_ABBREVIATION: CE5117
name: (3E,5Z,8Z)-tetradecatrienoyl-CoA
initial amount: NaN
is: SBO:0000247
type: Species
is: CHEBI:57923
has only substance units: false
constant: false

metaM HC01180 c
initial amount: NaN
constant: false
notes: FORMULA: C6H10O12P2 CHARGE: -4 INCHI: InChI=1S/C6H14O12P2/c7-4-3(1-16-19(10,11)12)18-6(9,5(4)8)2-17-20(13,14)15/h3-5,7-9H,1-2H2,(H2,10,11,12)(H2,13,14,15)/p-4/t3-,4+,5+,6?/m1/s1 EHMN_ABBREVIATION: C03785
initial concentration: 1.0
name: D-tagatofuranose 1,6-bisphosphate(4-)
boundary condition: false
is: SBO:0000247
has only substance units: false
is: CHEBI:58694
type: Species

metaR EX sph1p LPAREN e RPAREN
kinetic law: MODEL1310110042#
reactant: MODEL1310110042#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Sphinganine 1-phosphate exchange
type: Reaction

metaM nad c
name: Nicotinamide adenine dinucleotide
initial concentration: 1.0
type: Species
constant: false
is: SBO:0000247
is: http://identifiers.org/pubchem.compound/3305
initial amount: NaN
is: HMDB00902
is: C00003
boundary condition: false
is: CHEBI:57540
has only substance units: false

metaM lac L x
initial concentration: 1.0
is: CHEBI:16651
notes: FORMULA: C3H5O3 CHARGE: -1 INCHI: InChI=1S/C3H6O3/c1-2(4)3(5)6/h2,4H,1H3,(H,5,6)/p-1/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00177
name: (S)-lactate
initial amount: NaN
is: HMDB00190
has only substance units: false
is: SBO:0000247
constant: false
type: Species
boundary condition: false

metaR CYTK4
product: MODEL1310110042#
notes: GENE_ASSOCIATION: (26289.1) or (26289.2) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: PMID:10215863 NOTES:
name: cytidylate kinase (dCMP)(GTP)
fast: false
modifier: MODEL1310110042#
kinetic law: MODEL1310110042#
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/2.7.4.3
type: Reaction
reversible: true
reactant: MODEL1310110042#
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110042#_f13e52dd_65f2_4caf_beed_b73e7ed2b072
is: A8K0I1
type: Species
initial concentration: NaN
name: DGKH
initial amount: NaN
boundary condition: true
is encoded by: hsa:160851
constant: false
is: SBO:0000252
has only substance units: false

metaM cdp m
name: CDP(3-)
is: CHEBI:58069
is: HMDB01546
boundary condition: false
constant: false
notes: FORMULA: C9H12N3O11P2 CHARGE: -3 INCHI: InChI=1S/C9H15N3O11P2/c10-5-1-2-12(9(15)11-5)8-7(14)6(13)4(22-8)3-21-25(19,20)23-24(16,17)18/h1-2,4,6-8,13-14H,3H2,(H,19,20)(H2,10,11,15)(H2,16,17,18)/p-3/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00110 EHMN_ABBREVIATION: C00112
type: Species
is: SBO:0000247
initial concentration: 1.0
has only substance units: false
initial amount: NaN

metaR M1316Mg
type: Reaction
fast: false
kinetic law: MODEL1310110042#
is: SBO:0000176
modifier: MODEL1310110042#
is version of: http://identifiers.org/ec-code/3.2.1.114
notes: GENE_ASSOCIATION: (4124.1) or (4122.1) SUBSYSTEM: N-glycan synthesis EC Number: 3.2.1.114 Confidence Level: 0 AUTHORS: PMID:8524845 NOTES:NCD
reactant: MODEL1310110042#
name: mannosyl-oligosaccharide 1,3-1,6-alpha-mannosidase
is described by: ECO:0000000
product: MODEL1310110042#
reversible: false

metaR LSTO1r
type: Reaction
name: Lathosterol oxidase
is described by: ECO:0000269
kinetic law: MODEL1310110042#
is version of: http://identifiers.org/ec-code/1.14.21.6
fast: false
notes: GENE_ASSOCIATION: (6309.1) SUBSYSTEM: Cholesterol metabolism EC Number: 1.3.3.2 Confidence Level: 4 AUTHORS: PMID:10344195 NOTES:lanosterol -> cholesterol pathway NJ
modifier: MODEL1310110042#
reactant: MODEL1310110042#
product: MODEL1310110042#
reversible: false
is: SBO:0000176

metaM dolmanp U c
is: CHEBI:15809
is: SBO:0000247
name: Dolichyl phosphate D-mannose, human uterine homolog
notes: FORMULA: C1085H1780O90P10 CHARGE: -10 INCHI: InChI=1S/C31H55O9P/c1-22(2)11-7-12-23(3)13-8-14-24(4)15-9-16-25(5)17-10-18-26(6)19-20-38-41(36,37)40-31-30(35)29(34)28(33)27(21-32)39-31/h11,13,15,17,26-35H,7-10,12,14,16,18-21H2,1-6H3,(H,36,37)/b23-13+,24-15+,25-17-/t26?,27-,28-,29+,30+,31?/m1/s1
initial amount: NaN
has only substance units: false
boundary condition: false
initial concentration: 1.0
constant: false
type: Species

metaM tetpent3coa x
initial amount: NaN
is: C16167
type: Species
initial concentration: 1.0
name: tetracosapentaenoyl coenzyme A, n-3
notes: FORMULA: C45H68N7O17P3S CHARGE: -4 INCHI: InChI=1/C45H72N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-24-25-36(54)73-29-28-47-35(53)26-27-48-43(57)40(56)45(2,3)31-66-72(63,64)69-71(61,62)65-30-34-39(68-70(58,59)60)38(55)44(67-34)52-33-51-37-41(46)49-32-50-42(37)52/h5-6,8-9,11-12,14-15,17-18,32-34,38-40,44,55-56H,4,7,10,13,16,19-31H2,1-3H3,(H,47,53)(H,48,57)(H,61,62)(H,63,64)(H2,46,49,50)(H2,58,59,60)/b6-5-,9-8-,12-11-,15-14-,18-17-/t34-,38-,39-,40?,44-/m1/s1
has only substance units: false
boundary condition: false
is: SBO:0000247
constant: false

metaM c101crn e
initial amount: NaN
is: HMDB13205
type: Species
notes: FORMULA: C17H31NO4 CHARGE: 0
boundary condition: false
has only substance units: false
constant: false
initial concentration: 1.0
is: SBO:0000247
name: decenoyl carnitine

metaR BHBt
name: (R)-3-Hydroxybutanoate transport via H+ symport
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:1408469,PMID:16380372 NOTES:IT, TDV
is: SBO:0000185
kinetic law: MODEL1310110042#
reversible: true
product: MODEL1310110042#
type: Reaction
reactant: MODEL1310110042#
is described by: ECO:0000000
fast: false

metaR G13MT L
is described by: ECO:0000000
is: SBO:0000176
kinetic law: MODEL1310110042#
reversible: false
notes: GENE_ASSOCIATION: (85365.1) or (85365.2) SUBSYSTEM: N-glycan synthesis EC Number: 2.4.1.132 Confidence Level: 0 AUTHORS: NOTES:NCD
reactant: MODEL1310110042#
product: MODEL1310110042#
type: Reaction
fast: false
modifier: MODEL1310110042#
is version of: http://identifiers.org/ec-code/2.4.1.132
name: Glycolipid 1,3-alpha-D-mannosyltransferase (liver)

metaM biocyt c
is: C05552
type: Species
has only substance units: false
is: SBO:0000247
is: http://identifiers.org/pubchem.compound/7886
constant: false
initial amount: NaN
notes: FORMULA: C16H28N4O4S CHARGE: 0 INCHI: InChI=1/C16H28N4O4S/c17-10(15(22)23)5-3-4-8-18-13(21)7-2-1-6-12-14-11(9-25-12)19-16(24)20-14/h10-12,14H,1-9,17H2,(H,18,21)(H,22,23)(H2,19,20,24)/t10-,11-,12-,14-/m0/s1 EHMN_ABBREVIATION: C05552
name: Biocytin
boundary condition: false
initial concentration: 1.0
is: HMDB03134

http://identifiers.org/biomodels.db/MODEL1310110042#_cbe975c7_f5c1_4710_af6f_73e314b0d4e9
constant: false
initial amount: NaN
is: SBO:0000252
boundary condition: true
initial concentration: NaN
is: P39656
type: Species
name: DDOST
is encoded by: hsa:1650
has only substance units: false

metaR SQLSr
notes: GENE_ASSOCIATION: (2222.1) SUBSYSTEM: Cholesterol metabolism EC Number: 2.5.1.21 Confidence Level: 4 AUTHORS: PMID:1318747 NOTES:This is a lumped reaction: Rxn 1: 2 frdp -> 2 ppi + presqualene diphosphate Rxn 2: presqualene diphosphate + NADPH -> squalene + NADP NCD ER version - NJ
is version of: http://identifiers.org/ec-code/2.5.1.21
name: Squalene synthase
product: MODEL1310110042#
reactant: MODEL1310110042#
reversible: false
fast: false
is: SBO:0000176
kinetic law: MODEL1310110042#
modifier: MODEL1310110042#
type: Reaction
is described by: ECO:0000134

http://identifiers.org/biomodels.db/MODEL1310110042#_1b8ae9ab_e70e_4e3d_9c64_6e44e3b57327
initial amount: NaN
initial concentration: NaN
is: Q8TE04
is encoded by: hsa:53354
name: PANK1
type: Species
constant: false
has only substance units: false
boundary condition: true
is: SBO:0000252

metaR GLCNACASE3ly
notes: GENE_ASSOCIATION: (4669.1) SUBSYSTEM: Heparan sulfate degradation EC Number: 3.2.1.50 Confidence Level: 4 AUTHORS: PMID:1783617,PMID:8776591,PMID:8993162 NOTES:NCD
is: SBO:0000176
product: MODEL1310110042#
modifier: MODEL1310110042#
kinetic law: MODEL1310110042#
is described by: ECO:0000000
name: alpha-N-acetylglucosaminidase, lysosomal
type: Reaction
is version of: http://identifiers.org/ec-code/3.2.1.50
reversible: false
fast: false
reactant: MODEL1310110042#

metaR CYTK3
is version of: http://identifiers.org/ec-code/2.7.4.3
fast: false
product: MODEL1310110042#
notes: GENE_ASSOCIATION: (26289.1) or (26289.2) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: PMID:10215863 NOTES:
name: cytidylate kinase (CMP)(GTP)
type: Reaction
is described by: ECO:0000269
reactant: MODEL1310110042#
reversible: true
is: SBO:0000176
modifier: MODEL1310110042#
kinetic law: MODEL1310110042#

metaM ksi deg9 l
initial amount: NaN
is: SBO:0000247
type: Species
boundary condition: false
is: CHEBI:12936
name: keratan sulfate I, degradation product 9
constant: false
notes: FORMULA: C188H301N13O166S10 CHARGE: -10
is: HMDB00143
initial concentration: 1.0
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110042#_3d0c5ce8_7e55_46a9_bdc6_aa4d12fe1beb
is: Q9Y2P5
initial amount: NaN
type: Species
initial concentration: NaN
is: SBO:0000252
constant: false
is encoded by: hsa:10998
has only substance units: false
name: SLC27A5
boundary condition: true

metaM gtp m
has only substance units: false
notes: FORMULA: C10H12N5O14P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00051 EHMN_ABBREVIATION: C00044
boundary condition: false
name: GTP
is: HMDB01273
type: Species
is: SBO:0000247
is: CHEBI:37565
initial amount: NaN
constant: false
is: C00044
initial concentration: 1.0

metaR CYOR u10m
type: Reaction
is version of: http://identifiers.org/ec-code/3.5.1.92
kinetic law: MODEL1310110042#
fast: false
product: MODEL1310110042#
is version of: http://identifiers.org/ec-code/1.2.1.3
reversible: false
reactant: MODEL1310110042#
is described by: ECO:0000134
notes: GENE_ASSOCIATION: (8876.1) and (8875.2) and (55350.3) or (8876.1) and (8875.2) and (55350.2) or (8876.1) and (8875.1) and (55350.1) or (8876.1) and (55350.2) and (8875.1) or (8875.2) and (8876.1) and (55350.1) or (8876.1) and (55350.3) and (8875.1) or (AA081045.1) or (AI620219.1) or (219.1) or (217.1) or (224.1) or (501.1) or (223.1) or (AU149534.1) or (T83654.1) SUBSYSTEM: Oxidative phosphorylation EC Number: Confidence Level: 4 AUTHORS: PMID:10453733,PMID:11047755 NOTES:INVALID ECO TERM: IFH
name: ubiquinol-6 cytochrome c reductase, Complex III
modifier: MODEL1310110042#
is: SBO:0000185

metaM ascb L e
has only substance units: false
notes: FORMULA: C6H7O6 CHARGE: -1 INCHI: InChI=1S/C6H8O6/c7-1-2(8)5-3(9)4(10)6(11)12-5/h2,5,7-10H,1H2/p-1/t2-,5+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00074
constant: false
name: L-ascorbate
is: HMDB00044
boundary condition: false
is: CHEBI:38290
initial concentration: 1.0
type: Species
is: SBO:0000247
initial amount: NaN

metaM acnacngalgbside hs c
initial amount: NaN
is: SBO:0000247
type: Species
has only substance units: false
notes: FORMULA: C72H121N4O43FULLRCO CHARGE: -2
is: C00036
name: disialyl galactosylgloboside
is: CHEBI:3338
is: HMDB00223
boundary condition: false
initial concentration: 1.0
constant: false

http://identifiers.org/biomodels.db/MODEL1310110042#_7dd766b9_318b_4378_ade7_b5b55800d6ef
has only substance units: false
is: SBO:0000297
initial amount: NaN
has part: Q6FIH7
name: ATP5H:ATP5L:NSF:ATP5F1:ATP5G1:ATP5I:ATP5J:ATP5J2
type: Species
constant: false
initial concentration: NaN
is encoded by: hsa:516
boundary condition: true

metaR PMEVKx
is version of: http://identifiers.org/ec-code/2.7.4.2
reactant: MODEL1310110042#
type: Reaction
product: MODEL1310110042#
notes: GENE_ASSOCIATION: (10654.1) SUBSYSTEM: Cholesterol metabolism EC Number: 2.7.4.2 Confidence Level: 4 AUTHORS: PMID:11111079 NOTES:peroxisomal version - NJ
fast: false
is: SBO:0000176
name: phosphomevalonate kinase
is described by: ECO:0000134
reversible: false
modifier: MODEL1310110042#
kinetic law: MODEL1310110042#

metaR H2Oter
name: H2O endoplasmic reticulum transport
fast: false
type: Reaction
reversible: true
kinetic law: MODEL1310110042#
is: SBO:0000185
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD
product: MODEL1310110042#
reactant: MODEL1310110042#

metaR CYTK2
modifier: MODEL1310110042#
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: NOTES:
reactant: MODEL1310110042#
is version of: http://identifiers.org/ec-code/2.7.4.14
kinetic law: MODEL1310110042#
type: Reaction
fast: false
reversible: true
name: cytidylate kinase (dCMP)
is: SBO:0000176
product: MODEL1310110042#

http://identifiers.org/biomodels.db/MODEL1310110042#_4c23e965_a7f4_4d52_9228_b6e6bc92920c
name: ITPKC
is: SBO:0000252
type: Species
is encoded by: hsa:80271
constant: false
initial concentration: NaN
is: Q96DU7
initial amount: NaN
has only substance units: false
boundary condition: true

metaM sbcoa c
is: SBO:0000247
notes: FORMULA: C29H43N7O19P3S CHARGE: -5
constant: false
is: HMDB00791
initial amount: NaN
name: suberylcoa
has only substance units: false
boundary condition: false
type: Species
initial concentration: 1.0
is: C02838

metaM gtp n
boundary condition: false
has only substance units: false
is: CHEBI:37565
is: HMDB01273
type: Species
is: SBO:0000247
initial concentration: 1.0
initial amount: NaN
name: GTP(4-)
constant: false
notes: FORMULA: C10H12N5O14P3 CHARGE: -4 INCHI: InChI=1S/C10H16N5O14P3/c11-10-13-7-4(8(18)14-10)12-2-15(7)9-6(17)5(16)3(27-9)1-26-31(22,23)29-32(24,25)28-30(19,20)21/h2-3,5-6,9,16-17H,1H2,(H,22,23)(H,24,25)(H2,19,20,21)(H3,11,13,14,18)/p-4/t3-,5-,6-,9-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00051 EHMN_ABBREVIATION: C00044

metaM cholate e
is: SBO:0000247
boundary condition: false
is: HMDB00619
has only substance units: false
initial concentration: 1.0
type: Species
constant: false
notes: FORMULA: C24H39O5 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00502 EHMN_ABBREVIATION: C00695
initial amount: NaN
is: CHEBI:29747
name: Cholate

http://identifiers.org/biomodels.db/MODEL1310110042#_7feec4d7_84ea_49cc_967d_c78190c91916
boundary condition: true
constant: false
has only substance units: false
is encoded by: hsa:5152
name: PDE9A
initial amount: NaN
type: Species
is: SBO:0000252
initial concentration: NaN

metaR CERT1rt
reactant: MODEL1310110042#
reversible: true
kinetic law: MODEL1310110042#
notes: GENE_ASSOCIATION: (10087.1) SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: PMID:12803919,PMID:14685229,PMID:15596449,PMID:15907394 NOTES:non-vesicular intracellular transport of ceramide
type: Reaction
product: MODEL1310110042#
fast: false
is version of: http://identifiers.org/ec-code/2.7.11.1
is: SBO:0000185
modifier: MODEL1310110042#
is described by: ECO:0000304
name: ceramide transport protein

http://identifiers.org/biomodels.db/MODEL1310110042#_b17c7788_b183_4087_8568_8dc4f41d536e
constant: false
is encoded by: hsa:4023
name: LPL
has only substance units: false
is: SBO:0000252
boundary condition: true
type: Species
initial concentration: NaN
is: P06858
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110042#_d15b58bc_d4b2_49b1_9493_e76ca50f6b60
is encoded by: hsa:210
has only substance units: false
is: SBO:0000252
is: Q6ZMU0
constant: false
boundary condition: true
initial concentration: NaN
name: ALAD
type: Species
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110042#_d8aafb4c_8e2f_469e_95ec_4d3a4e20ae2a
is: GO:0005783
is: SBO:0000290
constant: false
size: 1.0
spatial dimensions: 3.0
name: endoplasmic reticulum
type: Compartment

metaM biocyt e
type: Species
is: SBO:0000247
is: http://identifiers.org/pubchem.compound/7886
constant: false
has only substance units: false
initial amount: NaN
notes: FORMULA: C16H28N4O4S CHARGE: 0 INCHI: InChI=1/C16H28N4O4S/c17-10(15(22)23)5-3-4-8-18-13(21)7-2-1-6-12-14-11(9-25-12)19-16(24)20-14/h10-12,14H,1-9,17H2,(H,18,21)(H,22,23)(H2,19,20,24)/t10-,11-,12-,14-/m0/s1 EHMN_ABBREVIATION: C05552
name: Biocytin
is: HMDB03134
boundary condition: false
is: C05552
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110042#_d458367f_c738_4129_8e01_c62841298c32
is encoded by: hsa:9365
initial concentration: NaN
type: Species
initial amount: NaN
is: SBO:0000252
boundary condition: true
has only substance units: false
is: Q9UEF7
name: KL
constant: false

metaR FACOAL200
reactant: MODEL1310110042#
name: fatty-acid--CoA ligase
modifier: MODEL1310110042#
kinetic law: MODEL1310110042#
type: Reaction
is: SBO:0000176
is described by: ECO:0000269
reversible: true
product: MODEL1310110042#
notes: GENE_ASSOCIATION: (2180.1) SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 4 AUTHORS: PMID:15292367 NOTES:NJ
is version of: http://identifiers.org/ec-code/6.2.1.3
fast: false

metaM nrvnc e
notes: FORMULA: C24H45O2 CHARGE: -1 INCHI: InChI=1S/C24H46O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-24(25)26/h9-10H,2-8,11-23H2,1H3,(H,25,26)/p-1/b10-9-
type: Species
initial amount: NaN
has only substance units: false
initial concentration: 1.0
is: CHEBI:32392
is: HMDB02368
is: SBO:0000247
name: nervonate
boundary condition: false
constant: false

metaR FAOXC81C61x
kinetic law: MODEL1310110042#
product: MODEL1310110042#
reactant: MODEL1310110042#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C8:1-->C6:1)x
type: Reaction

metaM 34hpp e
is: CHEBI:36242
notes: FORMULA: C9H7O4 CHARGE: -1 INCHI: InChI=1S/C9H8O4/c10-7-3-1-6(2-4-7)5-8(11)9(12)13/h1-4,10H,5H2,(H,12,13)/p-1
is: HMDB00707
initial amount: NaN
name: 3-(4-hydroxyphenyl)pyruvate
boundary condition: false
constant: false
has only substance units: false
is: SBO:0000247
initial concentration: 1.0
type: Species

http://identifiers.org/biomodels.db/MODEL1310110042#_c606d679_a2bc_4d66_82c3_5cd431bada79
constant: false
is encoded by: hsa:27115
initial amount: NaN
is: SBO:0000252
name: PDE7B
boundary condition: true
has only substance units: false
type: Species
is: Q9NP56
initial concentration: NaN

metaM docohexcoa m
is: http://identifiers.org/pubchem.compound/24892790
initial amount: NaN
type: Species
boundary condition: false
is: SBO:0000247
has only substance units: false
name: 2,4,7,10,13,16-docosahexenoylcoa
constant: false
notes: FORMULA: C43H62N7O17P3S CHARGE: -4
initial concentration: 1.0

metaR CYTK9
kinetic law: MODEL1310110042#
type: Reaction
modifier: MODEL1310110042#
reactant: MODEL1310110042#
is: SBO:0000176
is described by: ECO:0000269
product: MODEL1310110042#
name: cytidylate kinase (CMP,dCTP)
reversible: true
fast: false
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
is version of: http://identifiers.org/ec-code/2.7.4.14

metaR FACOAL204
reactant: MODEL1310110042#
is: SBO:0000176
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/6.2.1.3
notes: GENE_ASSOCIATION: (22305.1) or (2181.2) or (2181.1) or (2180.1) or (22305.2) or (2182.1) or (2182.2) SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 4 AUTHORS: PMID:15292367 NOTES:rev version so additional rxn doesn't need to be added to "unload" AA NJ. Merged GPR from FACOAL204 and FACOAL204i - (May 2011) IT
reversible: true
product: MODEL1310110042#
type: Reaction
fast: false
kinetic law: MODEL1310110042#
modifier: MODEL1310110042#
name: fatty-acid--CoA ligase

http://identifiers.org/biomodels.db/MODEL1310110042#_4dfafb88_4515_4c98_8daf_61e0fe94c66a
type: Species
initial amount: NaN
name: GLUL
constant: false
is: SBO:0000252
is encoded by: hsa:2752
boundary condition: true
has only substance units: false
is: P15104
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110042#_fa67b47c_ed74_4f2f_808b_34b55c6060c2
initial amount: NaN
has only substance units: false
is encoded by: hsa:5297
name: PI4KA
boundary condition: true
is: B4DYG5
constant: false
type: Species
is: SBO:0000252
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110042#_2f2dec97_06c5_4d61_898b_5d20e8654c8e
has only substance units: false
initial concentration: NaN
is encoded by: hsa:5151
is: O60658
is: SBO:0000252
boundary condition: true
constant: false
type: Species
name: PDE8A
initial amount: NaN

metaM ascb L c
initial amount: NaN
boundary condition: false
initial concentration: 1.0
notes: FORMULA: C6H7O6 CHARGE: -1 INCHI: InChI=1S/C6H8O6/c7-1-2(8)5-3(9)4(10)6(11)12-5/h2,5,7-10H,1H2/p-1/t2-,5+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00074
name: L-ascorbate
is: HMDB00044
is: CHEBI:38290
constant: false
is: SBO:0000247
type: Species
has only substance units: false

metaR GALtly
name: galactose efflux from lysosome
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 2 AUTHORS: PMID:1751541,PMID:8993166 NOTES:NCD
fast: false
reversible: false
is described by: ECO:0000000
kinetic law: MODEL1310110042#
product: MODEL1310110042#
is: SBO:0000185
type: Reaction
reactant: MODEL1310110042#

http://identifiers.org/biomodels.db/MODEL1310110042#_2c0fc137_094b_4595_870f_2c5ae949d676
is encoded by: hsa:80025
type: Species
initial amount: NaN
constant: false
is: SBO:0000252
has only substance units: false
is: Q6P1K9
boundary condition: true
name: PANK2
initial concentration: NaN

metaR EX duri LPAREN e RPAREN
kinetic law: MODEL1310110042#
reactant: MODEL1310110042#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for Deoxyuridine
type: Reaction

metaM n2m2masn g
name: ((N-acetyl-D-glucosaminyl)2-(alpha-D-mannosyl)2-beta-D-mannosyl-diacetylchitobiosyl)-L-asparagine (protein)
has only substance units: false
notes: FORMULA: C50H83N4O35X CHARGE: 0
boundary condition: false
type: Species
initial amount: NaN
constant: false
is: C11530
initial concentration: 1.0
is: SBO:0000247

metaR EX dhdascb LPAREN e RPAREN
kinetic law: MODEL1310110042#
reactant: MODEL1310110042#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for dehydroascorbide(1-)
type: Reaction

metaR r1871
fast: false
product: MODEL1310110042#
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
type: Reaction
name: Y+LAT2 Utilized transport
reactant: MODEL1310110042#
kinetic law: MODEL1310110042#
is: SBO:0000185
modifier: MODEL1310110042#
is described by: ECO:0000000
reversible: false

metaR GLNASNNaEx
kinetic law: MODEL1310110042#
product: MODEL1310110042#
notes: GENE_ASSOCIATION: (6510.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14530974 NOTES:SAB see Kanai and Hediger 2004 (2003), PMID 14530974
is described by: ECO:0000269
fast: false
is: SBO:0000185
reversible: false
reactant: MODEL1310110042#
modifier: MODEL1310110042#
name: L-glutamine/L-asparagine Na-dependent exchange (Gln-L in)
type: Reaction

metaR FAOXC4C4DCc
kinetic law: MODEL1310110042#
product: MODEL1310110042#
reactant: MODEL1310110042#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: succ-->C4DCc
type: Reaction

metaR FACOAL203
type: Reaction
modifier: MODEL1310110042#
reactant: MODEL1310110042#
notes: GENE_ASSOCIATION: (2180.1) SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 4 AUTHORS: PMID:15292367 NOTES:NJ
product: MODEL1310110042#
fast: false
kinetic law: MODEL1310110042#
name: fatty-acid--CoA ligase
is: SBO:0000176
is version of: http://identifiers.org/ec-code/6.2.1.3
reversible: true
is described by: ECO:0000000

metaR CYTK8
name: cytidylate kinase (CMP,dATP)
reversible: true
type: Reaction
modifier: MODEL1310110042#
is described by: ECO:0000269
product: MODEL1310110042#
is: SBO:0000176
fast: false
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
is version of: http://identifiers.org/ec-code/2.7.4.14
kinetic law: MODEL1310110042#
reactant: MODEL1310110042#

metaR CLS hs
fast: false
kinetic law: MODEL1310110042#
type: Reaction
reactant: MODEL1310110042#
name: cardiolipin synthase (homo sapiens)
modifier: MODEL1310110042#
notes: GENE_ASSOCIATION: (54675.1) SUBSYSTEM: Glycerophospholipid metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:10799718 NOTES:NJ
is described by: ECO:0000000
is: SBO:0000176
reversible: false
product: MODEL1310110042#

http://identifiers.org/biomodels.db/MODEL1310110042#_8fc2e247_0848_4594_b8a8_d96377a3fd60
type: Species
is: P49327
is: SBO:0000252
is encoded by: hsa:2194
boundary condition: true
name: FASN
constant: false
initial amount: NaN
has only substance units: false
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110042#_eb4d581b_3d2e_4f44_89d0_6c831bbb3c53
constant: false
initial amount: NaN
initial concentration: NaN
name: SYNJ1
is encoded by: hsa:8867
boundary condition: true
has only substance units: false
is: O43426
is: SBO:0000252
type: Species

http://identifiers.org/biomodels.db/MODEL1310110042#_fec708e2_aba7_4aa2_9e43_3315bf35190d
boundary condition: true
initial amount: NaN
initial concentration: NaN
is: SBO:0000252
type: Species
has only substance units: false
is: P07451
name: CA3
constant: false
is encoded by: hsa:761

metaM cholate c
name: Cholate
initial concentration: 1.0
has only substance units: false
notes: FORMULA: C24H39O5 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00502 EHMN_ABBREVIATION: C00695
is: CHEBI:29747
is: HMDB00619
constant: false
type: Species
initial amount: NaN
boundary condition: false
is: SBO:0000247

metaM HC00591 c
type: Species
is: CHEBI:16769
has only substance units: false
initial concentration: 1.0
initial amount: NaN
boundary condition: false
is: SBO:0000247
name: 2-oxoglutaramate
constant: false
notes: FORMULA: C5H6NO4 CHARGE: -1 INCHI: InChI=1S/C5H7NO4/c6-4(8)2-1-3(7)5(9)10/h1-2H2,(H2,6,8)(H,9,10)/p-1 EHMN_ABBREVIATION: C00940

http://identifiers.org/biomodels.db/MODEL1310110042#_18844e31_fd40_48f7_b6d0_11be9f7e01f7
name: ATP1A3:ATP1B2
initial amount: NaN
has only substance units: false
initial concentration: NaN
type: Species
boundary condition: true
constant: false
is encoded by: hsa:482
has part: P14415
is: SBO:0000297

metaR BACCL
reactant: MODEL1310110042#
reversible: false
is version of: http://identifiers.org/ec-code/6.3.4.10
notes: GENE_ASSOCIATION: (3141.1) SUBSYSTEM: Biotin metabolism EC Number: 6.3.4.15 Confidence Level: 4 AUTHORS: PMID:12459313,PMID:7842009 NOTES:IT
name: biotin-[acetyl-CoA-carboxylase] ligase
product: MODEL1310110042#
modifier: MODEL1310110042#
type: Reaction
fast: false
is: SBO:0000176
kinetic law: MODEL1310110042#
is described by: ECO:0000269

metaM succ e
type: Species
initial amount: NaN
has only substance units: false
is: SBO:0000247
constant: false
name: succinate(2-)
initial concentration: 1.0
notes: FORMULA: C4H4O4 CHARGE: -2 INCHI: InChI=1S/C4H6O4/c5-3(6)1-2-4(7)8/h1-2H2,(H,5,6)(H,7,8)/p-2 HEPATONET_1.0_ABBREVIATION: HC00049 EHMN_ABBREVIATION: C00042
boundary condition: false
is: HMDB00254
is: CHEBI:30031

metaM nrvnc c
type: Species
name: nervonate
boundary condition: false
is: CHEBI:32392
is: HMDB02368
is: SBO:0000247
initial concentration: 1.0
notes: FORMULA: C24H45O2 CHARGE: -1 INCHI: InChI=1S/C24H46O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-24(25)26/h9-10H,2-8,11-23H2,1H3,(H,25,26)/p-1/b10-9-
constant: false
initial amount: NaN
has only substance units: false

metaR FACOAL181i
modifier: MODEL1310110042#
notes: GENE_ASSOCIATION: (2180.1) or (2181.2) or (2181.1) SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 4 AUTHORS: NOTES:TV catalyzed by acyl-CoA synthetases
kinetic law: MODEL1310110042#
product: MODEL1310110042#
is described by: ECO:0000269
type: Reaction
fast: false
reactant: MODEL1310110042#
reversible: false
is version of: http://identifiers.org/ec-code/6.2.1.3
is: SBO:0000176
name: C181 fatty acid activation

metaM 34hpp c
notes: FORMULA: C9H7O4 CHARGE: -1 INCHI: InChI=1S/C9H8O4/c10-7-3-1-6(2-4-7)5-8(11)9(12)13/h1-4,10H,5H2,(H,12,13)/p-1 HEPATONET_1.0_ABBREVIATION: HC00699 EHMN_ABBREVIATION: C01179
constant: false
is: HMDB00707
is: SBO:0000247
name: 3-(4-hydroxyphenyl)pyruvate
type: Species
initial amount: NaN
initial concentration: 1.0
is: CHEBI:36242
has only substance units: false
boundary condition: false

metaR H2Otp
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD
product: MODEL1310110042#
reversible: true
fast: false
is: SBO:0000185
type: Reaction
name: H2O transport, peroxisomal
is described by: ECO:0000000
kinetic law: MODEL1310110042#
reactant: MODEL1310110042#

metaM 10fthf6glu e
name: 10-formyltetrahydrofolate-[Glu](6)
constant: false
is: SBO:0000247
is: HMDB00972
boundary condition: false
type: Species
initial amount: NaN
is: CHEBI:57454
initial concentration: 1.0
notes: FORMULA: C45H51N12O22 CHARGE: -7 INCHI: InChI=1/C45H58N12O22/c46-45-55-36-35(38(67)56-45)48-21(17-47-36)18-57(19-58)22-3-1-20(2-4-22)37(66)54-28(44(78)79)9-15-33(63)52-26(42(74)75)7-13-31(61)50-24(40(70)71)5-11-29(59)49-23(39(68)69)6-12-30(60)51-25(41(72)73)8-14-32(62)53-27(43(76)77)10-16-34(64)65/h1-4,19,21,23-28,48H,5-18H2,(H,49,59)(H,50,61)(H,51,60)(H,52,63)(H,53,62)(H,54,66)(H,64,65)(H,68,69)(H,70,71)(H,72,73)(H,74,75)(H,76,77)(H,78,79)(H4,46,47,55,56,67)/p-7/t21?,23?,24?,25?,26?,27?,28-/m1/s1
has only substance units: false

metaR CYTK7
type: Reaction
reversible: true
is version of: http://identifiers.org/ec-code/2.7.4.14
fast: false
kinetic law: MODEL1310110042#
is described by: ECO:0000269
is: SBO:0000176
product: MODEL1310110042#
name: cytidylate kinase (CMP,UTP)
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
modifier: MODEL1310110042#
reactant: MODEL1310110042#

metaR r1527
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (AI024818.1) or (AI091231.1) or (AI480132.1) or (AI972237.1) or (AL050025.1) or (759.1) or (771.1) or (377677.1) or (23632.1) or (760.1) or (761.1) or (762.1) or (763.1) or (11238.1) or (765.1) or (766.1) or (767.1) or (768.1) or (8883.1) or (R51273.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:16858612 NOTES:
kinetic law: MODEL1310110042#
modifier: MODEL1310110042#
fast: false
type: Reaction
reversible: false
product: MODEL1310110042#
is: SBO:0000185
name: ATP-binding Cassette (ABC) TCDB:3.A.1.211.1
reactant: MODEL1310110042#
is version of: http://identifiers.org/ec-code/4.2.1.1

metaR FACOAL206
kinetic law: MODEL1310110042#
name: fatty-acid--CoA ligase
modifier: MODEL1310110042#
reactant: MODEL1310110042#
is: SBO:0000176
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (11001.1) SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 4 AUTHORS: NOTES:NJ
type: Reaction
reversible: true
fast: false
is version of: http://identifiers.org/ec-code/6.2.1.3
product: MODEL1310110042#

http://identifiers.org/biomodels.db/MODEL1310110042#_54494690_0f4b_44a0_b69f_9694b72a34be
has only substance units: false
boundary condition: true
constant: false
type: Species
is: SBO:0000252
is: Q9NPC4
initial concentration: NaN
is encoded by: hsa:53947
name: A4GALT
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110042#_d79358f0_cdee_4351_9e45_947f913e93ca
constant: false
initial concentration: NaN
name: GPX1
is: SBO:0000252
is encoded by: hsa:2876
initial amount: NaN
type: Species
boundary condition: true
has only substance units: false

metaR NDPK10n
modifier: MODEL1310110042#
is version of: http://identifiers.org/ec-code/2.7.4.6
type: Reaction
reversible: true
kinetic law: MODEL1310110042#
is described by: ECO:0000304
reactant: MODEL1310110042#
notes: GENE_ASSOCIATION: (4831.1 and 4830.1) or (4830.2 and 4831.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.6 Confidence Level: 4 AUTHORS: PMID:7050910 NOTES:Many nucleoside diphosphates (eight described) can act as acceptors. While many ribo- and deoxyribonucleoside triphosphates can act as donors, only ATP is chosen as a donor to minimize the number of total reactions. . Presence in the nucleus
product: MODEL1310110042#
is: SBO:0000176
name: nucleoside-diphosphate kinase (ATP:dIDP), nuclear
fast: false

metaM arachdcoa r
name: arachidonoyl-CoA(4-)
initial amount: NaN
has only substance units: false
type: Species
is: SBO:0000247
initial concentration: 1.0
boundary condition: false
is: CHEBI:57368
notes: FORMULA: C41H62N7O17P3S CHARGE: -4 INCHI: InChI=1S/C41H66N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-32(50)69-25-24-43-31(49)22-23-44-39(53)36(52)41(2,3)27-62-68(59,60)65-67(57,58)61-26-30-35(64-66(54,55)56)34(51)40(63-30)48-29-47-33-37(42)45-28-46-38(33)48/h8-9,11-12,14-15,17-18,28-30,34-36,40,51-52H,4-7,10,13,16,19-27H2,1-3H3,(H,43,49)(H,44,53)(H,57,58)(H,59,60)(H2,42,45,46)(H2,54,55,56)/p-4/b9-8-,12-11-,15-14-,18-17-/t30-,34-,35-,36+,40-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01986 EHMN_ABBREVIATION: C02249
constant: false
is: HMDB06523

metaR C6COAt
kinetic law: MODEL1310110042#
product: MODEL1310110042#
reactant: MODEL1310110042#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: esterification of of hexanoylcoa for transport into cytosol
type: Reaction

metaM CE4793 x
boundary condition: false
is: CHEBI:57923
has only substance units: false
notes: FORMULA: C41H62N7O18P3S CHARGE: -4 INCHI: InChI=1/C41H66N7O18P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-29(49)24-32(51)70-23-22-43-31(50)20-21-44-39(54)36(53)41(2,3)26-63-69(60,61)66-68(58,59)62-25-30-35(65-67(55,56)57)34(52)40(64-30)48-28-47-33-37(42)45-27-46-38(33)48/h8-9,11-12,14-15,27-28,30,34-36,40,52-53H,4-7,10,13,16-26H2,1-3H3,(H,43,50)(H,44,54)(H,58,59)(H,60,61)(H2,42,45,46)(H2,55,56,57)/p-4/b9-8-,12-11-,15-14-/t30-,34+,35+,36u,40-/m0/s1 EHMN_ABBREVIATION: CE4793
is: SBO:0000247
name: 3-oxo-dihomo-gama-linolenoyl-CoA
constant: false
initial amount: NaN
initial concentration: 1.0
type: Species

metaM pa hs c
name: phosphatidate(2-)
has only substance units: false
is: CHEBI:57739
boundary condition: false
initial amount: NaN
type: Species
is: SBO:0000247
constant: false
notes: FORMULA: C3H5O4PFULLRCO2FULLR2CO2 CHARGE: -2 EHMN_ABBREVIATION: C00416
initial concentration: 1.0

metaR r2338
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12883891 NOTES:
is described by: ECO:0000000
fast: false
reversible: true
name: Major Facilitator(MFS) TCDB:2.A.1.19.1
product: MODEL1310110042#
kinetic law: MODEL1310110042#
reactant: MODEL1310110042#
type: Reaction
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110042#_cf6d209e_9cf0_493a_96fc_4ac7651e40b3
initial concentration: NaN
boundary condition: true
constant: false
name: COX4I1
type: Species
is: P13073
is encoded by: hsa:1327
initial amount: NaN
is: SBO:0000252
has only substance units: false

metaR CYTK6
is version of: http://identifiers.org/ec-code/2.7.4.14
fast: false
modifier: MODEL1310110042#
kinetic law: MODEL1310110042#
is described by: ECO:0000269
product: MODEL1310110042#
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
type: Reaction
reversible: true
reactant: MODEL1310110042#
name: cytidylate kinase (CMP,CTP)
is: SBO:0000176

metaR NACHEX8ly
is described by: ECO:0000000
fast: false
name: beta-N-acetylhexosaminidase, lysosomal
kinetic law: MODEL1310110042#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.2.1.52
product: MODEL1310110042#
notes: GENE_ASSOCIATION: (3073.1 and 3074.1) or (3074.1) or (3073.1) SUBSYSTEM: Chondroitin sulfate degradation EC Number: 3.2.1.52 Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12706724,PMID:8993162 NOTES:NCD
reversible: false
type: Reaction
reactant: MODEL1310110042#
modifier: MODEL1310110042#

http://identifiers.org/biomodels.db/MODEL1310110042#_e6bb3990_0ea9_4b3e_a161_aca036bae41e
is: P19440
is encoded by: hsa:2678
has only substance units: false
initial amount: NaN
boundary condition: true
type: Species
name: GGT1
initial concentration: NaN
constant: false
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110042#_2661e822_154f_403a_ac7b_ecf3e0a418ff
is: P23677
initial amount: NaN
is: SBO:0000252
constant: false
boundary condition: true
has only substance units: false
initial concentration: NaN
name: ITPKA
type: Species
is encoded by: hsa:3706

http://identifiers.org/biomodels.db/MODEL1310110042#_6c73ce61_47a6_42e5_a767_7b55bf971ba8
is: SBO:0000252
boundary condition: true
is encoded by: hsa:1635
name: DCTD
type: Species
is: P32321
initial concentration: NaN
initial amount: NaN
has only substance units: false
constant: false

metaR FACOAL205
reactant: MODEL1310110042#
is version of: http://identifiers.org/ec-code/6.2.1.3
modifier: MODEL1310110042#
notes: GENE_ASSOCIATION: (2180.1) SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 4 AUTHORS: PMID:15292367 NOTES:NJ
fast: false
product: MODEL1310110042#
is: SBO:0000176
kinetic law: MODEL1310110042#
name: fatty-acid--CoA ligase
is described by: ECO:0000000
type: Reaction
reversible: true

metaR FAOXC225C226m
kinetic law: MODEL1310110042#
product: MODEL1310110042#
reactant: MODEL1310110042#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C22:5-->C22:6)m
type: Reaction

metaM cyan e
name: hydrogen cyanide
is: SBO:0000247
type: Species
is: HMDB02084
notes: FORMULA: CHN CHARGE: 0 INCHI: InChI=1S/CHN/c1-2/h1H EHMN_ABBREVIATION: C01326
is: CHEBI:18407
initial amount: NaN
has only substance units: false
constant: false
boundary condition: false
initial concentration: 1.0

metaR r1873
reversible: false
type: Reaction
product: MODEL1310110042#
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reactant: MODEL1310110042#
name: Y+LAT2 Utilized transport
is: SBO:0000185
kinetic law: MODEL1310110042#
is described by: ECO:0000000
modifier: MODEL1310110042#
fast: false

metaR EX ala L LPAREN e RPAREN
kinetic law: MODEL1310110042#
reactant: MODEL1310110042#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for L-alanine
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110042#_a7062686_4dc8_4a19_8298_1af8f72974ae
is: P19634
boundary condition: true
initial concentration: NaN
constant: false
type: Species
initial amount: NaN
name: SLC9A1
is encoded by: hsa:6548
has only substance units: false
is: SBO:0000252

metaR CYSTGLUex
is described by: ECO:0000269
product: MODEL1310110042#
name: L-cystine/L-glutamate exchanger
is: SBO:0000185
notes: GENE_ASSOCIATION: (23657.1 and 6520.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14770310 NOTES:SAB see PMID 14770310
reversible: false
kinetic law: MODEL1310110042#
reactant: MODEL1310110042#
type: Reaction
modifier: MODEL1310110042#
fast: false

metaR r2111
product: MODEL1310110042#
reactant: MODEL1310110042#
type: Reaction
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
is described by: ECO:0000000
modifier: MODEL1310110042#
kinetic law: MODEL1310110042#
is: SBO:0000185
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
fast: false
reversible: true

metaR LNLNCAt
name: fatty acid transport via diffusion
reactant: MODEL1310110042#
fast: false
kinetic law: MODEL1310110042#
reversible: true
type: Reaction
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11788354,PMID:12864740 NOTES:NJ
is: SBO:0000185
product: MODEL1310110042#

http://identifiers.org/biomodels.db/MODEL1310110042#_f72dd679_8fb7_479f_9bdf_5ecea54c9216
initial amount: NaN
boundary condition: true
is: Q02153
is encoded by: hsa:2983
constant: false
is: SBO:0000252
type: Species
initial concentration: NaN
has only substance units: false
name: GUCY1B3

metaR HOCTDACBP
kinetic law: MODEL1310110042#
product: MODEL1310110042#
reactant: MODEL1310110042#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: transport of 3-hydroxyoctadecenoylcoa from mitochondria into the cytosol
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110042#_544eb026_0ee8_42e8_b04a_fddd0f0dfd9c
has only substance units: false
name: GLS2
constant: false
boundary condition: true
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:27165
is: SBO:0000252
type: Species

http://identifiers.org/biomodels.db/MODEL1310110042#_1f6898b4_9e32_436d_8a33_1dad1a12313c
has only substance units: false
initial amount: NaN
is encoded by: hsa:9963
name: SLC23A1
initial concentration: NaN
constant: false
type: Species
boundary condition: true
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110042#_0dcb2691_1eaf_48f0_908c_012f4590bc57
initial concentration: NaN
is encoded by: hsa:9107
has only substance units: false
name: MTMR6
initial amount: NaN
is: Q9Y217
type: Species
is: SBO:0000252
boundary condition: true
constant: false

http://identifiers.org/biomodels.db/MODEL1310110042#_85690736_d0c0_4720_93c1_32ea1a499cd7
is: SBO:0000252
is encoded by: hsa:9061
name: PAPSS1
initial amount: NaN
boundary condition: true
initial concentration: NaN
has only substance units: false
constant: false
is: O43252
type: Species

metaR r1591
reversible: true
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
type: Reaction
reactant: MODEL1310110042#
product: MODEL1310110042#
kinetic law: MODEL1310110042#
fast: false
is described by: ECO:0000000

metaR EX sbt DASH d LPAREN e RPAREN
kinetic law: MODEL1310110042#
reactant: MODEL1310110042#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for D-Sorbitol
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110042#_94661327_0e0e_4170_8bc0_74453692f4c1
has only substance units: false
initial concentration: NaN
name: CTPS2
boundary condition: true
constant: false
is: Q9NRF8
type: Species
initial amount: NaN
is: SBO:0000252
is encoded by: hsa:56474

metaR GLYAMDTRc
name: glycine amidinotransferase (c)
type: Reaction
reversible: true
product: MODEL1310110042#
kinetic law: MODEL1310110042#
is described by: ECO:0000269
reactant: MODEL1310110042#
is: SBO:0000176
notes: GENE_ASSOCIATION: (2628.1) SUBSYSTEM: Urea cycle EC Number: 2.1.4.1 Confidence Level: 4 AUTHORS: PMID:8547310 NOTES:SAB c
modifier: MODEL1310110042#
fast: false
is version of: http://identifiers.org/ec-code/2.1.4.1

metaM nrpphrsf e
is: SBO:0000247
initial concentration: 1.0
has only substance units: false
is: http://identifiers.org/pubchem.compound/123747
initial amount: NaN
notes: FORMULA: C8H11NO6S CHARGE: 0 INCHI: InChI=1/C8H11NO6S/c9-4-7(11)5-1-2-8(6(10)3-5)15-16(12,13)14/h1-3,7,10-11H,4,9H2,(H,12,13,14)/t7-/m0/s1
name: Sulfate derivative of norepinephrine
constant: false
is: HMDB02062
type: Species
boundary condition: false

metaR NACHEX22ly
type: Reaction
is described by: ECO:0000000
is: SBO:0000176
fast: false
modifier: MODEL1310110042#
is version of: http://identifiers.org/ec-code/3.2.1.52
reversible: false
reactant: MODEL1310110042#
name: beta-N-acetylhexosaminidase, lysosomal
kinetic law: MODEL1310110042#
notes: GENE_ASSOCIATION: (3074.1) or (3073.1 and 3074.1) or (3073.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.52 Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12706724,PMID:8993162 NOTES:NCD
product: MODEL1310110042#

metaM HC01434 x
initial concentration: 1.0
constant: false
has only substance units: false
boundary condition: false
is: SBO:0000247
notes: FORMULA: C6H3O7 CHARGE: -3 INCHI: InChI=1S/C6H6O7/c7-3(8)1-2(5(10)11)4(9)6(12)13/h2H,1H2,(H,7,8)(H,10,11)(H,12,13)/p-3 EHMN_ABBREVIATION: C05379
initial amount: NaN
name: oxalatosuccinate(3-)
type: Species
is: CHEBI:58931

metaR r2110
type: Reaction
modifier: MODEL1310110042#
is: SBO:0000185
product: MODEL1310110042#
is described by: ECO:0000000
fast: false
reactant: MODEL1310110042#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
reversible: true
kinetic law: MODEL1310110042#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1

metaR PDX5PO
fast: false
is described by: ECO:0000269
is: SBO:0000176
type: Reaction
modifier: MODEL1310110042#
product: MODEL1310110042#
notes: GENE_ASSOCIATION: (55163.1) SUBSYSTEM: Vitamin B6 metabolism EC Number: 1.4.3.5 Confidence Level: 4 AUTHORS: PMID:15182361,PMID:6380540 NOTES:NCD
reversible: true
name: pyridoxine 5'-phosphate oxidase
kinetic law: MODEL1310110042#
is version of: http://identifiers.org/ec-code/1.4.3.5
reactant: MODEL1310110042#

metaR SIAT4Bg
notes: GENE_ASSOCIATION: (6483.1) SUBSYSTEM: Sphingolipid metabolism EC Number: 2.4.99.4 Confidence Level: 4 AUTHORS: PMID:9266697 NOTES:NJ
modifier: MODEL1310110042#
is: SBO:0000176
product: MODEL1310110042#
type: Reaction
reactant: MODEL1310110042#
fast: false
is version of: http://identifiers.org/ec-code/2.4.99.4
name: Beta-galactoside alpha-2,3-sialyltransferase, Golgi apparatus
reversible: false
is described by: ECO:0000269
kinetic law: MODEL1310110042#

http://identifiers.org/biomodels.db/MODEL1310110042#_5a7a198a_24bb_48a9_bf53_d110a9cd0598
name: AK2
initial concentration: NaN
initial amount: NaN
boundary condition: true
is encoded by: hsa:204
has only substance units: false
constant: false
is: SBO:0000252
type: Species

http://identifiers.org/biomodels.db/MODEL1310110042#_b4cccee4_1408_4534_99c7_ac3b6237c838
has only substance units: false
is: SBO:0000252
type: Species
boundary condition: true
initial amount: NaN
is encoded by: hsa:AI971036
name: _AI971036_1_x
initial concentration: NaN
constant: false

metaM ksi deg15 l
initial amount: NaN
is: HMDB00143
boundary condition: false
is: CHEBI:12936
name: keratan sulfate I, degradation product 15
initial concentration: 1.0
type: Species
has only substance units: false
notes: FORMULA: C160H257N11O140S8 CHARGE: -8
is: SBO:0000247
constant: false

metaM fuc1p L c
name: L-Fucose 1-phosphate
type: Species
constant: false
boundary condition: false
has only substance units: false
is: SBO:0000247
notes: FORMULA: C6H11O8P CHARGE: -2 INCHI: InChI=1S/C6H13O8P/c1-2-3(7)4(8)5(9)6(13-2)14-15(10,11)12/h2-9H,1H3,(H2,10,11,12)/t2-,3+,4+,5-,6?/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01030
initial concentration: 1.0
initial amount: NaN
is: HMDB01265
is: CHEBI:28319

metaR r1590
is described by: ECO:0000000
reactant: MODEL1310110042#
product: MODEL1310110042#
reversible: true
kinetic law: MODEL1310110042#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
fast: false
type: Reaction
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110042#_1cb62d5f_082d_4caf_8b7b_c54d024d654c
initial concentration: NaN
is: SBO:0000252
boundary condition: true
type: Species
has only substance units: false
is encoded by: hsa:BF195998
initial amount: NaN
name: _BF195998_1_x
constant: false

metaR PCRNtm
reactant: MODEL1310110042#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: PMID:7654220 NOTES:NJ
reversible: false
product: MODEL1310110042#
fast: false
is: SBO:0000185
name: transport into the mitochondria from cytosol (carnitine)
kinetic law: MODEL1310110042#
type: Reaction

metaR r1980
name: Y+LAT2 Utilized transport
type: Reaction
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
kinetic law: MODEL1310110042#
reversible: false
product: MODEL1310110042#
is: SBO:0000185
is described by: ECO:0000000
modifier: MODEL1310110042#
fast: false
reactant: MODEL1310110042#

metaR LPS
kinetic law: MODEL1310110042#
notes: GENE_ASSOCIATION: (4023.1) SUBSYSTEM: Triacylglycerol synthesis EC Number: 3.1.1.3 Confidence Level: 4 AUTHORS: PMID:1969408 NOTES:carbonyl and extra H accounted for in R group NJ
reversible: false
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.1.1.34
modifier: MODEL1310110042#
type: Reaction
product: MODEL1310110042#
fast: false
is described by: ECO:0000000
name: lipase
reactant: MODEL1310110042#

http://identifiers.org/biomodels.db/MODEL1310110042#_52ace481_9f79_45ae_a4cd_d010e6d8830c
name: _N63787_1_c
type: Species
constant: false
initial amount: NaN
has only substance units: false
initial concentration: NaN
boundary condition: true
is encoded by: hsa:N63787
is: SBO:0000252

metaM gtp c
name: GTP
initial amount: NaN
has only substance units: false
is: HMDB01273
constant: false
initial concentration: 1.0
is: SBO:0000247
boundary condition: false
notes: FORMULA: C10H12N5O14P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00051 EHMN_ABBREVIATION: C00044
is: C00044
type: Species
is: CHEBI:37565

metaR FAOXC2242046x
is described by: ECO:0000269
type: Reaction
is version of: http://identifiers.org/ec-code/4.2.1.107
name: Beta oxidation of long chain fatty acid
modifier: MODEL1310110042#
is version of: http://identifiers.org/ec-code/2.3.1.16
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.3.3.6
fast: false
reactant: MODEL1310110042#
reversible: false
kinetic law: MODEL1310110042#
product: MODEL1310110042#
is version of: http://identifiers.org/ec-code/1.1.1.35
notes: GENE_ASSOCIATION: (3295.1 and 30.1 and 51.2) or (51.1 and 30.1 and 1962.1) or (30.1 and 51.2 and 1962.1) or (51.1 and 3295.1 and 30.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.74 Confidence Level: 4 AUTHORS: NOTES:_1 round beta ox - in peroxisome, no fad, 1ste set of beta-ox is by acyl-coa oxidase (passes electrons directly to o2 -> h2o2) peroxisomal (very long chain FA) c22:4,n-6 -> c20:4, n-6 - final '6' in abbreviation indicates omega6 FA 4 step FAO lumped for 2 rounds also includes EC 1.1.1.35, 1.1.1.211, 1.3.3.6, 4.2.1.17, 4.2.1.74 NJ

metaR DMNONCRNCPT2
name: DMNONCRNCPT2
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 2 AUTHORS: PMID:9299016,PMID:9819701 NOTES:
kinetic law: MODEL1310110042#
reversible: true
reactant: MODEL1310110042#
is: SBO:0000176
type: Reaction
product: MODEL1310110042#
fast: false

metaR SERASNNaEx
name: L-serine/L-asparagine Na-dependent exchange (Ser-L in)
reversible: false
product: MODEL1310110042#
notes: GENE_ASSOCIATION: (6510.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14530974 NOTES:SAB see Kanai and Hediger 2004 (2003), PMID 14530974
reactant: MODEL1310110042#
type: Reaction
modifier: MODEL1310110042#
fast: false
kinetic law: MODEL1310110042#
is described by: ECO:0000269
is: SBO:0000185

metaR r0033
is version of: http://identifiers.org/ec-code/3.6.1.5
type: Reaction
product: MODEL1310110042#
kinetic law: MODEL1310110042#
modifier: MODEL1310110042#
is: SBO:0000176
name: ATP:dephospho-CoA 3-phosphotransferase Pantothenate and CoA biosynthesis EC:2.7.1.24
reactant: MODEL1310110042#
fast: false
notes: GENE_ASSOCIATION: (AV717590.1) or (953.1) or (956.1) or (377841.1) SUBSYSTEM: CoA synthesis EC Number: 2.7.1.24 Confidence Level: 0 AUTHORS: PMID:11923312,PMID:11994049,PMID:13163064,PMID:15893380 NOTES:
is described by: ECO:0000000
reversible: false

metaR S3TASE3ly
product: MODEL1310110042#
type: Reaction
is described by: ECO:0000000
kinetic law: MODEL1310110042#
reactant: MODEL1310110042#
fast: false
reversible: true
is: SBO:0000176
name: N-acetylglucosamine-3-sulfatase, lysosomal
notes: GENE_ASSOCIATION: SUBSYSTEM: Heparan sulfate degradation EC Number: 3.1.6.15 Confidence Level: 2 AUTHORS: PMID:7396957,PMID:8993162 NOTES:NCD

metaM gtp e
constant: false
initial amount: NaN
is: HMDB01273
initial concentration: 1.0
has only substance units: false
notes: FORMULA: C10H12N5O14P3 CHARGE: -4 INCHI: InChI=1S/C10H16N5O14P3/c11-10-13-7-4(8(18)14-10)12-2-15(7)9-6(17)5(16)3(27-9)1-26-31(22,23)29-32(24,25)28-30(19,20)21/h2-3,5-6,9,16-17H,1H2,(H,22,23)(H,24,25)(H2,19,20,21)(H3,11,13,14,18)/p-4/t3-,5-,6-,9-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00051 EHMN_ABBREVIATION: C00044
is: SBO:0000247
is: CHEBI:37565
name: GTP(4-)
type: Species
boundary condition: false

metaR EX pydx5p LPAREN e RPAREN
kinetic law: MODEL1310110042#
reactant: MODEL1310110042#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of pyridoxal 5-phosphate(2-)
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110042#_06847661_7291_46b9_b3c6_0083e271013a
name: GPD2
is: SBO:0000252
type: Species
is encoded by: hsa:2820
boundary condition: true
constant: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
is: P43304

http://identifiers.org/biomodels.db/MODEL1310110042#_1ff3d708_7e13_4ca9_b8dd_f88acb7043af
name: PIGV
is encoded by: hsa:55650
boundary condition: true
type: Species
initial concentration: NaN
is: Q9NUD9
constant: false
has only substance units: false
is: SBO:0000252
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110042#_1971c302_7c8c_44fd_a9a9_bacd91c4ca90
initial amount: NaN
name: ALDH18A1
is: P54886
is: SBO:0000252
boundary condition: true
type: Species
initial concentration: NaN
is encoded by: hsa:5832
constant: false
has only substance units: false

metaR r1418
kinetic law: MODEL1310110042#
name: Carbonic acid hydro-lyase Nitrogen metabolism EC:4.2.1.1
type: Reaction
reversible: true
fast: false
product: MODEL1310110042#
is: SBO:0000176
reactant: MODEL1310110042#
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 4.2.1.1 Confidence Level: 0 AUTHORS: PMID:10938543,PMID:11493685,PMID:12713833,PMID:12747791,PMID:14640555,PMID:17259996,PMID:17504134,PMID:17826101,PMID:7011879,PMID:7672338 NOTES:
is described by: ECO:0000000

metaR FAOXC142C122m
kinetic law: MODEL1310110042#
product: MODEL1310110042#
reactant: MODEL1310110042#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C14:2-->C12:2)m
type: Reaction

metaM galside hs c
type: Species
is: CHEBI:12947
initial amount: NaN
constant: false
is: SBO:0000247
initial concentration: 1.0
name: D-galactosyl-N-acylsphingosine
boundary condition: false
has only substance units: false
notes: FORMULA: C24H46NO7FULLRCO CHARGE: 0 EHMN_ABBREVIATION: C02686

metaR GALASE13ly
is version of: http://identifiers.org/ec-code/3.2.1.23
is version of: http://identifiers.org/ec-code/3.4.16.5
fast: false
is version of: http://identifiers.org/ec-code/3.1.6.4
is version of: http://identifiers.org/ec-code/3.2.1.18
reactant: MODEL1310110042#
type: Reaction
reversible: false
product: MODEL1310110042#
modifier: MODEL1310110042#
name: beta-galactosidase, lysosomal
is described by: ECO:0000000
kinetic law: MODEL1310110042#
is: SBO:0000176
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) or (5476.1) and (2720.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.23 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD

metaR r2335
reactant: MODEL1310110042#
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
is: SBO:0000185
kinetic law: MODEL1310110042#
is described by: ECO:0000000
product: MODEL1310110042#
fast: false
type: Reaction

metaM nrpphrsf c
name: Sulfate derivative of norepinephrine
initial concentration: 1.0
is: http://identifiers.org/pubchem.compound/123747
boundary condition: false
constant: false
type: Species
has only substance units: false
is: SBO:0000247
initial amount: NaN
notes: FORMULA: C8H11NO6S CHARGE: 0 INCHI: InChI=1/C8H11NO6S/c9-4-7(11)5-1-2-8(6(10)3-5)15-16(12,13)14/h1-3,7,10-11H,4,9H2,(H,12,13,14)/t7-/m0/s1
is: HMDB02062

http://identifiers.org/biomodels.db/MODEL1310110042#_01bd194b_7636_44a8_98af_28a2d5d120df
initial amount: NaN
name: ACAD11
has only substance units: false
constant: false
type: Species
is: Q709F0
is: SBO:0000252
initial concentration: NaN
is encoded by: hsa:84129
boundary condition: true

metaM 5aop m
is: CHEBI:17549
name: 5-Amino-4-oxopentanoate
boundary condition: false
has only substance units: false
initial amount: NaN
is: C00430
constant: false
type: Species
initial concentration: 1.0
is: SBO:0000247
notes: FORMULA: C5H9NO3 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00349 EHMN_ABBREVIATION: C00430
is: HMDB01149

http://identifiers.org/biomodels.db/MODEL1310110042#_b91bebd4_4cd0_48c2_b382_29633df07ca8
initial concentration: NaN
is: SBO:0000252
boundary condition: true
type: Species
is: P60891
is encoded by: hsa:5631
constant: false
initial amount: NaN
has only substance units: false
name: PRPS1

metaR AK2LGCHOLt
product: MODEL1310110042#
is: SBO:0000185
fast: false
reactant: MODEL1310110042#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: 4.1.1.21 Confidence Level: 2 AUTHORS: PMID:2004782,PMID:2253271,PMID:8106516 NOTES:
type: Reaction
is described by: ECO:0000269
name: 1-alkyl 2-acylglycerol 3-phosphocholine transport
kinetic law: MODEL1310110042#
reversible: true

metaR FUMSO3tm
modifier: MODEL1310110042#
fast: false
type: Reaction
is: SBO:0000185
notes: GENE_ASSOCIATION: (1468.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172,PMID:4441366 NOTES:MM
product: MODEL1310110042#
reactant: MODEL1310110042#
is described by: ECO:0000269
reversible: true
kinetic law: MODEL1310110042#
name: Fumarate:sulfite antiport, mitochondrial

metaM hdcoa c
constant: false
has only substance units: false
is: SBO:0000247
is: HMDB06532
type: Species
notes: FORMULA: C37H60N7O17P3S CHARGE: -4
name: Hexadecenoyl-CoA (n-C16:1CoA)
initial concentration: 1.0
boundary condition: false
initial amount: NaN

metaR r1982
kinetic law: MODEL1310110042#
is: SBO:0000185
fast: false
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is described by: ECO:0000000
product: MODEL1310110042#
modifier: MODEL1310110042#
type: Reaction
name: Y+LAT2 Utilized transport
reversible: false
reactant: MODEL1310110042#

http://identifiers.org/biomodels.db/MODEL1310110042#_aad16d6a_7938_469c_a233_ea4e326f9424
initial amount: NaN
has only substance units: false
is: SBO:0000252
initial concentration: NaN
type: Species
boundary condition: true
name: PRDX1
is encoded by: hsa:5052
constant: false

metaR r2334
fast: false
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
reactant: MODEL1310110042#
is described by: ECO:0000000
kinetic law: MODEL1310110042#
is: SBO:0000185
product: MODEL1310110042#
reversible: true
type: Reaction

metaR r2044
is: SBO:0000185
reactant: MODEL1310110042#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.15
fast: false
type: Reaction
reversible: false
product: MODEL1310110042#
modifier: MODEL1310110042#
kinetic law: MODEL1310110042#
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is described by: ECO:0000000

metaR CYTK11
is version of: http://identifiers.org/ec-code/2.7.4.14
name: cytidylate kinase (dCMP,dGTP)
type: Reaction
reactant: MODEL1310110042#
reversible: true
modifier: MODEL1310110042#
is: SBO:0000176
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
product: MODEL1310110042#
is described by: ECO:0000269
kinetic law: MODEL1310110042#
fast: false

metaR MECOAS1m
is version of: http://identifiers.org/ec-code/6.2.1.4
kinetic law: MODEL1310110042#
name: mesaconate--CoA ligase (GDP-forming)
modifier: MODEL1310110042#
reactant: MODEL1310110042#
product: MODEL1310110042#
reversible: true
notes: GENE_ASSOCIATION: (8802.1 and 8801.1) SUBSYSTEM: C5-branched dibasic acid metabolism EC Number: 6.2.1.4 Confidence Level: 2 AUTHORS: PMID:13783048 NOTES:IF
type: Reaction
fast: false
is described by: ECO:0000304
is: SBO:0000176

metaM acnacngalgbside hs e
initial concentration: 1.0
constant: false
initial amount: NaN
type: Species
has only substance units: false
is: C00036
boundary condition: false
is: HMDB00223
is: SBO:0000247
notes: FORMULA: C72H121N4O43FULLRCO CHARGE: -2
name: disialyl galactosylgloboside
is: CHEBI:3338

http://identifiers.org/biomodels.db/MODEL1310110042#_f391eb44_fac3_4207_825a_113dcfcbc952
is encoded by: hsa:57835
initial concentration: NaN
is: Q9BY07
name: SLC4A5
has only substance units: false
initial amount: NaN
constant: false
type: Species
boundary condition: true
is: SBO:0000252

metaR r2333
reversible: true
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
product: MODEL1310110042#
is: SBO:0000185
kinetic law: MODEL1310110042#
is described by: ECO:0000000
fast: false
type: Reaction
reactant: MODEL1310110042#

metaM ile L c
name: L-isoleucine
type: Species
is: SBO:0000247
initial concentration: 1.0
has only substance units: false
constant: false
notes: FORMULA: C6H13NO2 CHARGE: 0 INCHI: InChI=1S/C6H13NO2/c1-3-4(2)5(7)6(8)9/h4-5H,3,7H2,1-2H3,(H,8,9)/t4-,5-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00334 EHMN_ABBREVIATION: C00407
is: HMDB00172
is: CHEBI:17191
boundary condition: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110042#_b6227548_d36a_4233_9fb2_8790b3b451de
initial amount: NaN
constant: false
initial concentration: NaN
has only substance units: false
type: Species
is encoded by: hsa:53354
is: SBO:0000252
name: PANK1
boundary condition: true

metaM 34hpp m
has only substance units: false
initial concentration: 1.0
is: CHEBI:36242
is: HMDB00707
constant: false
notes: FORMULA: C9H7O4 CHARGE: -1 INCHI: InChI=1S/C9H8O4/c10-7-3-1-6(2-4-7)5-8(11)9(12)13/h1-4,10H,5H2,(H,12,13)/p-1 HEPATONET_1.0_ABBREVIATION: HC00699 EHMN_ABBREVIATION: C01179
type: Species
name: 3-(4-hydroxyphenyl)pyruvate
is: SBO:0000247
boundary condition: false
initial amount: NaN

metaM prpp c
is: HMDB00280
name: 5-Phospho-alpha-D-ribose 1-diphosphate
constant: false
initial concentration: 1.0
has only substance units: false
initial amount: NaN
is: C00119
notes: FORMULA: C5H8O14P3 CHARGE: -5 HEPATONET_1.0_ABBREVIATION: HC00117 EHMN_ABBREVIATION: C00119
is: CHEBI:58017
type: Species
boundary condition: false
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110042#_add3dc3b_13b5_4dd8_996d_d4432ecadc18
boundary condition: true
is: Q10471
initial concentration: NaN
has only substance units: false
type: Species
initial amount: NaN
constant: false
is encoded by: hsa:2590
name: GALNT2
is: SBO:0000252

metaR FACOAL1831
notes: GENE_ASSOCIATION: (2180.1) SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 4 AUTHORS: PMID:15292367 NOTES:NJ
reversible: true
is version of: http://identifiers.org/ec-code/6.2.1.3
type: Reaction
product: MODEL1310110042#
fast: false
reactant: MODEL1310110042#
name: fatty-acid--CoA ligase
kinetic law: MODEL1310110042#
modifier: MODEL1310110042#
is: SBO:0000176
is described by: ECO:0000269

metaR NDPK3m
is described by: ECO:0000254
product: MODEL1310110042#
fast: false
name: nucleoside-diphosphate kinase (ATP:CDP), mitochondrial
kinetic law: MODEL1310110042#
modifier: MODEL1310110042#
is version of: http://identifiers.org/ec-code/2.7.4.6
reversible: true
notes: GENE_ASSOCIATION: (4833.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.6 Confidence Level: 2 AUTHORS: PMID:9099850 NOTES:Many nucleoside diphosphates (eight described) can act as acceptors. While many ribo- and deoxyribonucleoside triphosphates can act as donors, only ATP is chosen as a donor to minimize the number of total reactions.
type: Reaction
is: SBO:0000176
reactant: MODEL1310110042#

http://identifiers.org/biomodels.db/MODEL1310110042#_6e5411a7_8ad3_4b35_a224_fa13d5ef0fa4
is encoded by: hsa:2194
initial amount: NaN
is: SBO:0000252
has only substance units: false
type: Species
boundary condition: true
is: P49327
initial concentration: NaN
name: FASN
constant: false

metaR BETALDHxm
reactant: MODEL1310110042#
fast: false
name: betaine-aldehyde dehydrogenase, mitochondrial
notes: GENE_ASSOCIATION: SUBSYSTEM: Glycine, serine, alanine and threonine metabolism EC Number: 1.2.1.8 Confidence Level: 2 AUTHORS: PMID:15321791 NOTES:MM
reversible: false
product: MODEL1310110042#
kinetic law: MODEL1310110042#
is described by: ECO:0000000
is: SBO:0000176
type: Reaction

metaR CYTK10
is described by: ECO:0000269
reversible: true
is version of: http://identifiers.org/ec-code/2.7.4.14
modifier: MODEL1310110042#
fast: false
type: Reaction
is: SBO:0000176
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
product: MODEL1310110042#
reactant: MODEL1310110042#
name: cytidylate kinase (CMP,dGTP)
kinetic law: MODEL1310110042#

metaR DRBK
fast: false
product: MODEL1310110042#
reactant: MODEL1310110042#
modifier: MODEL1310110042#
is described by: ECO:0000304
type: Reaction
kinetic law: MODEL1310110042#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.7.1.15
notes: GENE_ASSOCIATION: (64080.1) SUBSYSTEM: Pentose phosphate pathway EC Number: 2.7.1.15 Confidence Level: 2 AUTHORS: PMID:9693094 NOTES:NCD
name: Deoxyribokinase
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110042#_d522f3f2_aa65_49ce_814a_480ec333ddc5
type: Species
boundary condition: true
initial amount: NaN
is: P35557
name: GCK
is: SBO:0000252
constant: false
has only substance units: false
initial concentration: NaN
is encoded by: hsa:2645

http://identifiers.org/biomodels.db/MODEL1310110042#_40bff6e1_7cdb_47ca_885b_80dcac91c29d
constant: false
initial concentration: NaN
is encoded by: hsa:55568
initial amount: NaN
type: Species
name: GALNT10
boundary condition: true
is: SBO:0000252
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110042#_e43800dd_5cc3_4fd1_8d81_7611bba465f5
is: SBO:0000252
name: HLCS
initial concentration: NaN
is encoded by: hsa:3141
boundary condition: true
is: P50747
has only substance units: false
constant: false
initial amount: NaN
type: Species

metaR EX ocdcea LPAREN e RPAREN
kinetic law: MODEL1310110042#
reactant: MODEL1310110042#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: octadecenoate (n-C18:1) exchange
type: Reaction

metaR r2332
type: Reaction
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
product: MODEL1310110042#
is described by: ECO:0000000
reversible: true
fast: false
is: SBO:0000185
kinetic law: MODEL1310110042#
reactant: MODEL1310110042#

metaM ocdca c
type: Species
is: SBO:0000247
boundary condition: false
name: stearate
is: CHEBI:25629
has only substance units: false
is: HMDB00827
constant: false
initial amount: NaN
initial concentration: 1.0
notes: FORMULA: C18H35O2 CHARGE: -1 INCHI: InChI=1S/C18H36O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20/h2-17H2,1H3,(H,19,20)/p-1 EHMN_ABBREVIATION: C01530

metaM ksi pre25 g
is: CHEBI:58053
name: keratan sulfate I biosynthesis, precursor 25
type: Species
initial amount: NaN
is: HMDB00175
constant: false
is: SBO:0000247
has only substance units: false
is: C00130
initial concentration: 1.0
notes: FORMULA: C199H319N14O163S7X CHARGE: -8
boundary condition: false

metaR ALAR
reactant: MODEL1310110042#
reversible: true
kinetic law: MODEL1310110042#
notes: GENE_ASSOCIATION: (11212.1) SUBSYSTEM: Alanine and aspartate metabolism EC Number: 5.1.1.1 Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000212
product: MODEL1310110042#
type: Reaction
is: SBO:0000176
name: alanine racemase
modifier: MODEL1310110042#
fast: false

http://identifiers.org/biomodels.db/MODEL1310110042#_030ae6fa_b742_46ef_afd6_4f12e6808d79
constant: false
initial concentration: NaN
has only substance units: false
initial amount: NaN
boundary condition: true
is: SBO:0000252
is encoded by: hsa:6173
type: Species
is: P83881
name: RPL36A

http://identifiers.org/biomodels.db/MODEL1310110042#_a5b3e498_a73d_4b8f_87df_adaebde46226
initial amount: NaN
is encoded by: hsa:5145
name: PDE6A
boundary condition: true
type: Species
initial concentration: NaN
has only substance units: false
is: SBO:0000252
is: P16499
constant: false

metaR EX 3mob LPAREN e RPAREN
kinetic law: MODEL1310110042#
reactant: MODEL1310110042#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: Exchange of 3-methyl-2-oxobutanoate
type: Reaction

metaR EX crvnc LPAREN e RPAREN
kinetic law: MODEL1310110042#
reactant: MODEL1310110042#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: nC22:6 exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110042#_027d5f2e_e6dd_4fa0_9adb_401ceb0023cd
boundary condition: true
is: SBO:0000252
is: Q9UBK5
has only substance units: false
initial concentration: NaN
type: Species
constant: false
name: HCST
initial amount: NaN
is encoded by: hsa:10870

http://identifiers.org/biomodels.db/MODEL1310110042#_dfb93ba8_d3a6_4f8d_a6f8_621b3f6e25ec
constant: false
initial amount: NaN
initial concentration: NaN
boundary condition: true
has only substance units: false
name: PRPS2
is: P11908
is encoded by: hsa:5634
is: SBO:0000252
type: Species

http://identifiers.org/biomodels.db/MODEL1310110042#_767fab90_0dec_467e_b669_65ec1c8d3fd3
initial concentration: NaN
has only substance units: false
constant: false
type: Species
initial amount: NaN
boundary condition: true
name: SDHA
is: P31040
is: SBO:0000252
is encoded by: hsa:6389

http://identifiers.org/biomodels.db/MODEL1310110042#_4c83a2c8_5478_4ad6_8101_592e7da5b009
name: NIT2
initial concentration: NaN
is encoded by: hsa:56954
is: SBO:0000252
is: Q9NQR4
boundary condition: true
initial amount: NaN
type: Species
has only substance units: false
constant: false

metaR NDPK3n
reversible: true
reactant: MODEL1310110042#
modifier: MODEL1310110042#
product: MODEL1310110042#
name: nucleoside-diphosphate kinase (ATP:CDP),nuclear
type: Reaction
fast: false
is described by: ECO:0000304
is version of: http://identifiers.org/ec-code/2.7.4.6
notes: GENE_ASSOCIATION: (4831.1 and 4830.1) or (4830.2 and 4831.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.6 Confidence Level: 4 AUTHORS: PMID:7050910 NOTES:Many nucleoside diphosphates (eight described) can act as acceptors. While many ribo- and deoxyribonucleoside triphosphates can act as donors, only ATP is chosen as a donor to minimize the number of total reactions.. Presence in the nucleus
kinetic law: MODEL1310110042#
is: SBO:0000176

metaM acnacngalgbside hs g
initial concentration: 1.0
initial amount: NaN
boundary condition: false
has only substance units: false
is: CHEBI:3338
constant: false
name: disialyl galactosylgloboside
type: Species
is: C00036
is: HMDB00223
notes: FORMULA: C72H121N4O43FULLRCO CHARGE: -2
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110042#_5d619bbe_6b76_4dbd_9234_d9f2e2fc4e10
is: P10619
boundary condition: true
is: SBO:0000252
initial amount: NaN
has only substance units: false
initial concentration: NaN
is encoded by: hsa:5476
constant: false
name: CTSA
type: Species

metaR GACMTRc
name: guanidinoacetate N-methyltransferase (c)
product: MODEL1310110042#
is version of: http://identifiers.org/ec-code/2.1.1.2
modifier: MODEL1310110042#
is described by: ECO:0000269
type: Reaction
is: SBO:0000176
kinetic law: MODEL1310110042#
reversible: true
reactant: MODEL1310110042#
notes: GENE_ASSOCIATION: (2593.1) or (2593.2) SUBSYSTEM: Urea cycle EC Number: 2.1.1.2 Confidence Level: 4 AUTHORS: PMID:2001229 NOTES:SAB c
fast: false

http://identifiers.org/biomodels.db/MODEL1310110042#_c0bec6b6_bdc8_4197_8ade_1ecfe1b8978f
constant: false
initial concentration: NaN
initial amount: NaN
boundary condition: true
type: Species
is encoded by: hsa:29922
has only substance units: false
is: Q9Y5B8
is: SBO:0000252
name: NME7

http://identifiers.org/biomodels.db/MODEL1310110042#_4a655238_306c_4600_8b0c_e5b5da070653
type: Species
constant: false
has only substance units: false
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:FLJ44968
boundary condition: true
name: _FLJ44968_1_m
initial amount: NaN

metaR r2331
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
product: MODEL1310110042#
fast: false
type: Reaction
kinetic law: MODEL1310110042#
is: SBO:0000185
is described by: ECO:0000000
reversible: true
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
reactant: MODEL1310110042#

metaM succ m
has only substance units: false
constant: false
is: HMDB00254
initial amount: NaN
is: CHEBI:30031
is: C00042
initial concentration: 1.0
notes: FORMULA: C4H4O4 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00049 EHMN_ABBREVIATION: C00042
type: Species
is: SBO:0000247
boundary condition: false
name: Succinate

http://identifiers.org/biomodels.db/MODEL1310110042#_3ee412e8_bca4_48ee_af79_dc2229149d82
is encoded by: hsa:498
constant: false
name: ATP5A1
is: SBO:0000252
is: B4DY56
type: Species
initial concentration: NaN
has only substance units: false
boundary condition: true
initial amount: NaN

metaR EX crn LPAREN e RPAREN
kinetic law: MODEL1310110042#
reactant: MODEL1310110042#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for L-Carnitine
type: Reaction

metaR PROSTGE2t
kinetic law: MODEL1310110042#
reversible: true
product: MODEL1310110042#
reactant: MODEL1310110042#
is described by: ECO:0000269
modifier: MODEL1310110042#
name: prostaglandin transport via bicarbonate countertransport
fast: false
is: SBO:0000185
type: Reaction
notes: GENE_ASSOCIATION: (28231.1) or (6578.1) or (28232.1) or (6579.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12507753,PMID:8787677,PMID:9334206 NOTES:NJ

metaM docoscoa x
has only substance units: false
constant: false
initial concentration: 1.0
type: Species
initial amount: NaN
is: HMDB12930
notes: FORMULA: C43H74N7O17P3S CHARGE: -4
name: docosanoylcoa
is: SBO:0000247
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110042#_cad11858_0e6b_47bd_a061_470f37ac5f4b
initial amount: NaN
constant: false
is encoded by: hsa:5244
is: A4D1D5
type: Species
name: ABCB4
boundary condition: true
is: SBO:0000252
initial concentration: NaN
has only substance units: false

metaM ile L e
name: L-isoleucine
is: CHEBI:17191
has only substance units: false
boundary condition: false
initial concentration: 1.0
is: SBO:0000247
is: HMDB00172
initial amount: NaN
type: Species
constant: false
notes: FORMULA: C6H13NO2 CHARGE: 0 INCHI: InChI=1S/C6H13NO2/c1-3-4(2)5(7)6(8)9/h4-5H,3,7H2,1-2H3,(H,8,9)/t4-,5-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00334 EHMN_ABBREVIATION: C00407

metaM HC01842 c
is: CHEBI:31997
type: Species
boundary condition: false
initial concentration: 1.0
notes: FORMULA: C4H10NO4P CHARGE: -2 INCHI: InChI=1S/C4H12NO4P/c1-5(2)3-4-9-10(6,7)8/h3-4H2,1-2H3,(H2,6,7,8)
has only substance units: false
name: Phosphodimethylethanolamine
initial amount: NaN
constant: false
is: SBO:0000247

metaM prpp e
is: HMDB00280
constant: false
name: 5-O-phosphonato-alpha-D-ribofuranosyl diphosphate(5-)
initial amount: NaN
initial concentration: 1.0
has only substance units: false
is: CHEBI:58017
type: Species
is: SBO:0000247
boundary condition: false
notes: FORMULA: C5H8O14P3 CHARGE: -5 INCHI: InChI=1S/C5H13O14P3/c6-3-2(1-16-20(8,9)10)17-5(4(3)7)18-22(14,15)19-21(11,12)13/h2-7H,1H2,(H,14,15)(H2,8,9,10)(H2,11,12,13)/p-5/t2-,3-,4-,5-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00117 EHMN_ABBREVIATION: C00119

metaM mi34p c
initial concentration: 1.0
initial amount: NaN
is: CHEBI:28858
constant: false
type: Species
name: 1D-myo-Inositol 3,4-bisphosphate
boundary condition: false
is: HMDB06235
has only substance units: false
notes: FORMULA: C6H10O12P2 CHARGE: -4 INCHI: InChI=1S/C6H14O12P2/c7-1-2(8)4(10)6(18-20(14,15)16)5(3(1)9)17-19(11,12)13/h1-10H,(H2,11,12,13)(H2,14,15,16)/t1-,2-,3-,4+,5-,6-/m0/s1 EHMN_ABBREVIATION: C04063
is: SBO:0000247

metaR CYTK13
is described by: ECO:0000269
is: SBO:0000176
fast: false
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
reactant: MODEL1310110042#
modifier: MODEL1310110042#
is version of: http://identifiers.org/ec-code/2.7.4.14
kinetic law: MODEL1310110042#
reversible: true
product: MODEL1310110042#
type: Reaction
name: cytidylate kinase (dCMP,dATP)

metaM cyan m
constant: false
is: SBO:0000247
has only substance units: false
initial amount: NaN
is: CHEBI:18407
notes: FORMULA: CHN CHARGE: 0 INCHI: InChI=1S/CHN/c1-2/h1H EHMN_ABBREVIATION: C01326
type: Species
is: HMDB02084
boundary condition: false
initial concentration: 1.0
name: hydrogen cyanide

metaR CYTK12
type: Reaction
kinetic law: MODEL1310110042#
reversible: true
fast: false
name: cytidylate kinase (dCMP,dCTP)
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.7.4.14
modifier: MODEL1310110042#
reactant: MODEL1310110042#
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
product: MODEL1310110042#
is described by: ECO:0000269

metaM gd3 hs g
is: SBO:0000247
initial concentration: 1.0
initial amount: NaN
boundary condition: false
notes: FORMULA: C52H88N3O28FULLRCO CHARGE: -2
has only substance units: false
constant: false
type: Species
name: GD3
is: CHEBI:28424

http://identifiers.org/biomodels.db/MODEL1310110042#_35364dc5_23d0_44d7_ae6b_c6d04ab89b1f
type: Species
has only substance units: false
is: SBO:0000297
initial amount: NaN
is encoded by: hsa:1962
has part: Q9NY65
boundary condition: true
constant: false
name: EHHADH:ACAA1:ACOX1
initial concentration: NaN

metaR FAOXC2442246x
name: Beta oxidation of long chain fatty acid
product: MODEL1310110042#
is version of: http://identifiers.org/ec-code/2.3.1.16
is version of: http://identifiers.org/ec-code/4.2.1.107
kinetic law: MODEL1310110042#
modifier: MODEL1310110042#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.3.3.6
reactant: MODEL1310110042#
reversible: false
type: Reaction
notes: GENE_ASSOCIATION: (51.1 and 3295.1 and 30.1) or (51.1 and 30.1 and 1962.1) or (30.1 and 51.2 and 1962.1) or (3295.1 and 30.1 and 51.2) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.74 Confidence Level: 4 AUTHORS: NOTES:_1 round beta ox - - in peroxisome, no fad, 1ste set of beta-ox is by acyl-coa oxidase (passes electrons directly to o2 -> h2o2) peroxisomal (very long chain FA) c24:4,n-6 -> c22:4, n-6 - final '6' in abbreviation indicates omega6 FA 4 step FAO lumped for 2 rounds also includes EC 1.1.1.35, 1.1.1.211, 1.3.3.6, 4.2.1.17, 4.2.1.74 NJ
is version of: http://identifiers.org/ec-code/1.1.1.35
fast: false
is described by: ECO:0000269

metaR RE1516M
notes: GENE_ASSOCIATION: (33.1) or (51.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.99.13 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:11356167,PMID:8973539 NOTES:
fast: false
reactant: MODEL1310110042#
is: SBO:0000176
modifier: MODEL1310110042#
kinetic law: MODEL1310110042#
is described by: ECO:0000000
product: MODEL1310110042#
reversible: true
type: Reaction
name: RE1516
is version of: http://identifiers.org/ec-code/1.3.99.13
is version of: http://identifiers.org/ec-code/1.3.3.6

metaR r2330
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
reactant: MODEL1310110042#
type: Reaction
product: MODEL1310110042#
reversible: true
is described by: ECO:0000000
fast: false
kinetic law: MODEL1310110042#
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2

metaM phyt2ohcoa x
initial amount: NaN
initial concentration: 1.0
boundary condition: false
type: Species
is: CHEBI:57334
notes: FORMULA: C41H70N7O18P3S CHARGE: -4 INCHI: InChI=1S/C41H74N7O18P3S/c1-25(2)11-8-12-26(3)13-9-14-27(4)15-10-16-28(5)32(50)40(54)70-20-19-43-30(49)17-18-44-38(53)35(52)41(6,7)22-63-69(60,61)66-68(58,59)62-21-29-34(65-67(55,56)57)33(51)39(64-29)48-24-47-31-36(42)45-23-46-37(31)48/h23-29,32-35,39,50-52H,8-22H2,1-7H3,(H,43,49)(H,44,53)(H,58,59)(H,60,61)(H2,42,45,46)(H2,55,56,57)/p-4/t26?,27?,28?,29-,32?,33-,34-,35+,39-/m1/s1 EHMN_ABBREVIATION: C07343
constant: false
has only substance units: false
name: 2-hydroxyphytanoyl-CoA(4-)
is: HMDB01295
is: SBO:0000247

metaM ocdca e
is: C01530
has only substance units: false
name: octadecanoate (n-C18:0)
is: CHEBI:25629
is: SBO:0000247
type: Species
initial amount: NaN
notes: FORMULA: C18H35O2 CHARGE: -1 EHMN_ABBREVIATION: C01530
initial concentration: 1.0
is: HMDB00827
boundary condition: false
constant: false

metaR UDPtl
fast: false
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 1 AUTHORS: NOTES:unknown mechanism for transport - not known if it is energy dependent or not, recycling and IC transport is important to get it to other areas of the cell (e.g. plasma membrane) - translocators have been found for ER and Golgi - none found for lysosome yet so non-mechanistic transporter added - in future this will need to be revised _when_ a translocator is found NJ
reversible: true
kinetic law: MODEL1310110042#
name: udp intracellular transport
type: Reaction
reactant: MODEL1310110042#
product: MODEL1310110042#
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110042#_aad70093_b822_4b02_bb07_32b3fa4c7105
type: Species
has only substance units: false
boundary condition: true
is: Q9UHV8
is: SBO:0000252
initial concentration: NaN
is encoded by: hsa:29124
constant: false
name: LGALS13
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110042#_478a6041_b95a_4f95_8eca_4d43a059b0de
constant: false
boundary condition: true
is: P56385
type: Species
is encoded by: hsa:521
name: ATP5I
initial amount: NaN
initial concentration: NaN
has only substance units: false
is: SBO:0000252

metaR FACOAL1832
is described by: ECO:0000269
reversible: true
type: Reaction
is version of: http://identifiers.org/ec-code/6.2.1.3
is: SBO:0000176
modifier: MODEL1310110042#
product: MODEL1310110042#
notes: GENE_ASSOCIATION: (2180.1) SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 4 AUTHORS: PMID:15292367 NOTES:NJ, RE3114C
fast: false
reactant: MODEL1310110042#
name: fatty-acid--CoA ligase
kinetic law: MODEL1310110042#

metaR GLYSNAT5tc
kinetic law: MODEL1310110042#
product: MODEL1310110042#
reactant: MODEL1310110042#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: transport of Glycine into the cell coupled with co-transport with Sodium and counter transport with proton by SNAT5 transporter.
type: Reaction

metaM acgal1p c
initial amount: NaN
notes: FORMULA: C8H14NO9P CHARGE: -2 INCHI: InChI=1S/C8H16NO9P/c1-3(11)9-5-7(13)6(12)4(2-10)17-8(5)18-19(14,15)16/h4-8,10,12-13H,2H2,1H3,(H,9,11)(H2,14,15,16)/t4-,5-,6+,7-,8?/m1/s1
boundary condition: false
initial concentration: 1.0
name: N-Acetyl-D-galactosamine 1-phosphate
has only substance units: false
is: CHEBI:55404
constant: false
type: Species
is: SBO:0000247
is: HMDB06480

http://identifiers.org/biomodels.db/MODEL1310110042#_a2ddcbce_1a14_4d14_9cd0_cdd61cfae6ea
is: P04746
is encoded by: hsa:279
has only substance units: false
initial amount: NaN
is: SBO:0000252
constant: false
boundary condition: true
name: AMY2A
type: Species
initial concentration: NaN

metaR DHAAt1r
product: MODEL1310110042#
name: dehydroascorbate transport (uniport)
modifier: MODEL1310110042#
kinetic law: MODEL1310110042#
fast: false
notes: GENE_ASSOCIATION: (6515.1) or (6513.1) or (6517.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10421229,PMID:12750891,PMID:15705056,PMID:2656669,PMID:3170580,PMID:8504756,PMID:9230074 NOTES:NCD
reversible: true
is described by: ECO:0000269
reactant: MODEL1310110042#
is: SBO:0000185
type: Reaction

metaR LEUKTRD4t
product: MODEL1310110042#
is described by: ECO:0000269
reversible: true
name: leukotriene D4 transport
reactant: MODEL1310110042#
type: Reaction
fast: false
kinetic law: MODEL1310110042#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10358072,PMID:12507753,PMID:9334206 NOTES:
is: SBO:0000185

metaR EX gtp LPAREN e RPAREN
kinetic law: MODEL1310110042#
reactant: MODEL1310110042#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: GTP exchange
type: Reaction

metaR EX 3bcrn
kinetic law: MODEL1310110042#
reactant: MODEL1310110042#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for 3-hydroxy butyryl carnitine
type: Reaction

metaR r1598
is described by: ECO:0000000
type: Reaction
reversible: true
kinetic law: MODEL1310110042#
fast: false
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is: SBO:0000185
product: MODEL1310110042#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reactant: MODEL1310110042#

metaR r1976
kinetic law: MODEL1310110042#
is: SBO:0000185
modifier: MODEL1310110042#
reactant: MODEL1310110042#
is described by: ECO:0000000
name: Y+LAT2 Utilized transport
fast: false
type: Reaction
product: MODEL1310110042#
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110042#_891a71f2_e4ae_46fd_ab8d_d6dbcc99bfb0
boundary condition: true
is: C7ECU1
type: Species
initial concentration: NaN
is encoded by: hsa:59272
constant: false
has only substance units: false
initial amount: NaN
is: SBO:0000252
name: ACE2

metaR THRSERNaEx
modifier: MODEL1310110042#
product: MODEL1310110042#
name: L-serine/L-threonine Na-dependent exchange (Thr-L in)
fast: false
reactant: MODEL1310110042#
type: Reaction
notes: GENE_ASSOCIATION: (6509.1) or (6510.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14530974 NOTES:SAB see Kanai and Hediger 2004 (2003), PMID 14530974
is: SBO:0000185
reversible: false
kinetic law: MODEL1310110042#
is described by: ECO:0000269

metaR CYTK14
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
is version of: http://identifiers.org/ec-code/2.7.4.14
kinetic law: MODEL1310110042#
is: SBO:0000176
is described by: ECO:0000269
name: cytidylate kinase (dCMP,UTP)
reversible: true
modifier: MODEL1310110042#
product: MODEL1310110042#
fast: false
type: Reaction
reactant: MODEL1310110042#

metaR GLCter
kinetic law: MODEL1310110042#
name: glucose transport, endoplasmic reticulum
is: SBO:0000185
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: PMID:11879177 NOTES:NCD
type: Reaction
fast: false
is described by: ECO:0000000
reactant: MODEL1310110042#
product: MODEL1310110042#

http://identifiers.org/biomodels.db/MODEL1310110042#_d5c73642_7c7e_49ba_9cd5_9528651b1734
is encoded by: hsa:10587
name: TXNRD2
is: SBO:0000252
initial amount: NaN
has only substance units: false
initial concentration: NaN
boundary condition: true
constant: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110042#_284a7464_8166_4044_ae78_dbd6b4c445d9
is: SBO:0000252
is: Q5K4L6
is encoded by: hsa:11000
initial amount: NaN
type: Species
initial concentration: NaN
boundary condition: true
constant: false
name: SLC27A3
has only substance units: false

metaR EX dgmp LPAREN e RPAREN
kinetic law: MODEL1310110042#
reactant: MODEL1310110042#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of dGMP(2-)
type: Reaction

metaR r2118
reactant: MODEL1310110042#
is described by: ECO:0000000
fast: false
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
product: MODEL1310110042#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
modifier: MODEL1310110042#
type: Reaction
reversible: true
is: SBO:0000185
kinetic law: MODEL1310110042#

metaR SFCYSc
type: Reaction
name: Formation of sulfocysteine
kinetic law: MODEL1310110042#
product: MODEL1310110042#
is: SBO:0000176
is described by: ECO:0000134
reversible: true
fast: false
reactant: MODEL1310110042#
notes: GENE_ASSOCIATION: SUBSYSTEM: Methionine and cysteine metabolism EC Number: Confidence Level: 2 AUTHORS: PMID: 2621485 NOTES:non-enzymatic reaction. Sulfocysteine is excreted in the urine.One proton added for elemental balancing.

metaR r0494
fast: false
is described by: ECO:0000000
type: Reaction
is: SBO:0000176
kinetic law: MODEL1310110042#
reversible: true
reactant: MODEL1310110042#
product: MODEL1310110042#
notes: GENE_ASSOCIATION: SUBSYSTEM: Pyrimidine catabolism EC Number: 3.6.1.5 Confidence Level: 0 AUTHORS: PMID:15652174,PMID:16752921,PMID:17095758 NOTES:
name: dTDP diphosphohydrolase Pyrimidine metabolism EC:3.6.1.5

metaM galside hs l
is: CHEBI:12947
boundary condition: false
is: SBO:0000247
initial amount: NaN
initial concentration: 1.0
type: Species
constant: false
has only substance units: false
notes: FORMULA: C24H46NO7FULLRCO CHARGE: 0 EHMN_ABBREVIATION: C02686
name: D-galactosyl-N-acylsphingosine

metaM pail35p hs c
name: 1-phosphatidyl-1D-myo-inositol 3,5-bisphosphate(5-)
constant: false
boundary condition: false
notes: FORMULA: C9H14O15P3FULLRCO2FULLR2CO2 CHARGE: -5
initial concentration: 1.0
type: Species
has only substance units: false
initial amount: NaN
is: SBO:0000247
is: CHEBI:57923

metaR RE1531M
product: MODEL1310110042#
is version of: http://identifiers.org/ec-code/2.3.1.16
fast: false
is: SBO:0000176
name: RE1531
kinetic law: MODEL1310110042#
type: Reaction
notes: GENE_ASSOCIATION: (10449.1) or (3032.1) or (3030.1) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.16 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:7923814,PMID:9568246,PMID:9920399 NOTES:
is version of: http://identifiers.org/ec-code/4.2.1.17
is described by: ECO:0000000
reversible: true
modifier: MODEL1310110042#
reactant: MODEL1310110042#

metaR FAOXTC142TC122m
kinetic law: MODEL1310110042#
product: MODEL1310110042#
reactant: MODEL1310110042#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation trans(C14:2-->C12:2)m
type: Reaction

metaR r1599
reversible: true
reactant: MODEL1310110042#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
kinetic law: MODEL1310110042#
fast: false
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is described by: ECO:0000000
is: SBO:0000185
product: MODEL1310110042#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110042#_966475ef_1aeb_46de_bb86_f51a3bc35793
boundary condition: true
constant: false
type: Species
is: SBO:0000252
initial concentration: NaN
has only substance units: false
is encoded by: hsa:6785
initial amount: NaN
is: Q9GZR5
name: ELOVL4

metaR LGNCt
name: fatty acid transport via diffusion
product: MODEL1310110042#
kinetic law: MODEL1310110042#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11788354,PMID:12864740 NOTES:NJ
reversible: true
is: SBO:0000185
fast: false
type: Reaction
is described by: ECO:0000000
reactant: MODEL1310110042#

metaM 5aop c
notes: FORMULA: C5H9NO3 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00349 EHMN_ABBREVIATION: C00430
constant: false
has only substance units: false
initial concentration: 1.0
boundary condition: false
is: C00430
is: CHEBI:17549
is: HMDB01149
name: 5-Amino-4-oxopentanoate
initial amount: NaN
is: SBO:0000247
type: Species

metaM 3hexdtricoa x
has only substance units: false
initial concentration: 1.0
type: Species
name: 3,7,10-hexadecatrienoylcoa
initial amount: NaN
constant: false
notes: FORMULA: C37H56N7O17P3S CHARGE: -4
boundary condition: false
is: HMDB02288
is: SBO:0000247

metaM ksi deg35 l
constant: false
is: SBO:0000247
type: Species
is: CHEBI:12936
initial concentration: 1.0
notes: FORMULA: C68H113N4O54S1 CHARGE: -1
boundary condition: false
has only substance units: false
is: HMDB00143
initial amount: NaN
name: keratan sulfate I, degradation product 35

metaR HEXCt
fast: false
type: Reaction
reversible: true
name: fatty acid transport via diffusion
product: MODEL1310110042#
reactant: MODEL1310110042#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11788354,PMID:12864740 NOTES:NJ
is described by: ECO:0000000
kinetic law: MODEL1310110042#
is: SBO:0000185

metaR r2119
reversible: true
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
product: MODEL1310110042#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
is: SBO:0000185
reactant: MODEL1310110042#
kinetic law: MODEL1310110042#
type: Reaction
fast: false
modifier: MODEL1310110042#

http://identifiers.org/biomodels.db/MODEL1310110042#_146c0061_8445_4b92_99a4_4268fe9ffcb6
initial amount: NaN
has only substance units: false
initial concentration: NaN
is: Q14442
boundary condition: true
type: Species
is: SBO:0000252
constant: false
name: PIGH
is encoded by: hsa:5283

metaR RE0830C
reversible: true
name: RE0830
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Tetrahydrobiopterin metabolism EC Number: 4.2.1.96 Confidence Level: 0 AUTHORS: PMID:10727395,PMID:1355046,PMID:1988938 NOTES:
product: MODEL1310110042#
type: Reaction
reactant: MODEL1310110042#
is: SBO:0000176
kinetic law: MODEL1310110042#
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110042#_af21421a_4713_4633_ac6a_2bb3b0e20805
initial concentration: NaN
is encoded by: hsa:515
boundary condition: true
is: SBO:0000252
has only substance units: false
initial amount: NaN
constant: false
name: ATP5F1
type: Species

http://identifiers.org/biomodels.db/MODEL1310110042#_06205c9b_b1b9_4438_9dbc_c1b5524bfc94
is: SBO:0000252
initial amount: NaN
name: NME6
initial concentration: NaN
constant: false
is: O75414
type: Species
has only substance units: false
boundary condition: true
is encoded by: hsa:10201

metaR r0899
name: Amino acid transporter ATB0+ Facilitated diffusion
type: Reaction
product: MODEL1310110042#
fast: false
is: SBO:0000185
reversible: true
is described by: ECO:0000000
kinetic law: MODEL1310110042#
reactant: MODEL1310110042#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:10721894,PMID:11787643,PMID:12269802,PMID:12504794,PMID:16955229,PMID:17401668,PMID:18599538,PMID:3132542,PMID:487087,PMID:551321,PMID:6418146,PMID:7731061,PMID:8010975,PMID:8382624,PMID:8654117,PMID:8899554,PMID:911815,PMID:917262 NOTES:

metaR 5OXPROt
is described by: ECO:0000134
fast: false
kinetic law: MODEL1310110042#
type: Reaction
product: MODEL1310110042#
is: SBO:0000185
name: Transport of 5-oxoprolinate
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
reactant: MODEL1310110042#

metaM cs a deg5 l
initial concentration: 1.0
has only substance units: false
is: SBO:0000247
name: chondroitin sulfate A (GalNAc4S-GlcA), degradation product 5
is: CHEBI:15936
notes: FORMULA: C23H36O24S CHARGE: -2
boundary condition: false
initial amount: NaN
type: Species
constant: false

metaM pectingchol e
is: SBO:0000247
type: Species
has only substance units: false
initial concentration: 1.0
is: HMDB03402
initial amount: NaN
notes: FORMULA: C2561H3553NO2541 CHARGE: 0
boundary condition: false
name: pectin-glycocholate complex
constant: false

metaR DOPASFt
reversible: false
is described by: ECO:0000000
name: Dopamine 3-0-sulfate transport (diffusion)
kinetic law: MODEL1310110042#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 1 AUTHORS: NOTES:SAB excretion of dopamine sulfate
reactant: MODEL1310110042#
product: MODEL1310110042#
fast: false
is: SBO:0000185
type: Reaction

metaM nad r
type: Species
constant: false
notes: FORMULA: C21H26N7O14P2 CHARGE: -1 INCHI: InChI=1S/C21H27N7O14P2/c22-17-12-19(25-7-24-17)28(8-26-12)21-16(32)14(30)11(41-21)6-39-44(36,37)42-43(34,35)38-5-10-13(29)15(31)20(40-10)27-3-1-2-9(4-27)18(23)33/h1-4,7-8,10-11,13-16,20-21,29-32H,5-6H2,(H5-,22,23,24,25,33,34,35,36,37)/p-1/t10-,11-,13-,14-,15-,16-,20-,21-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00013 EHMN_ABBREVIATION: C00003
is: SBO:0000247
is: CHEBI:57540
is: HMDB00902
initial amount: NaN
has only substance units: false
initial concentration: 1.0
boundary condition: false
name: NAD(1-)

metaR XOLDIOLONEt
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: PMID:12840657 NOTES:cholesterol precursor, transport by "diffusion" -> actually beleived to be flip-flop mechanism (PMID: 12840657). NJ
fast: false
reactant: MODEL1310110042#
is: SBO:0000185
name: lipid, flip-flop intracellular transport
is described by: ECO:0000000
kinetic law: MODEL1310110042#
product: MODEL1310110042#
reversible: true

metaR SPODMm
modifier: MODEL1310110042#
notes: GENE_ASSOCIATION: (6648.1) SUBSYSTEM: ROS detoxification EC Number: 1.15.1.1 Confidence Level: 2 AUTHORS: PMID:12649272,PMID:9376114 NOTES:TV (8-15-2003)
type: Reaction
kinetic law: MODEL1310110042#
is described by: ECO:0000304
reactant: MODEL1310110042#
is version of: http://identifiers.org/ec-code/1.15.1.1
is: SBO:0000176
reversible: false
product: MODEL1310110042#
fast: false
name: superoxide dismutase

metaM dhbpt c
name: 6,7-dihydrobiopterin
is: SBO:0000247
is: CHEBI:20680
boundary condition: false
is: HMDB00038
constant: false
notes: FORMULA: C9H13N5O3 CHARGE: 0 INCHI: InChI=1S/C9H13N5O3/c1-3(15)6(16)4-2-11-7-5(12-4)8(17)14-9(10)13-7/h3-4,6,15-16H,2H2,1H3,(H3,10,11,13,14,17) HEPATONET_1.0_ABBREVIATION: HC00242 EHMN_ABBREVIATION: C00268
initial concentration: 1.0
initial amount: NaN
type: Species
has only substance units: false

metaR r2116
reversible: true
kinetic law: MODEL1310110042#
is described by: ECO:0000000
product: MODEL1310110042#
modifier: MODEL1310110042#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
reactant: MODEL1310110042#
fast: false
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
type: Reaction
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110042#_67bd8b7b_f0de_4de3_9872_ee5828e9e0b4
is encoded by: hsa:8871
name: SYNJ2
initial concentration: NaN
has only substance units: false
initial amount: NaN
type: Species
is: O15056
constant: false
is: SBO:0000252
boundary condition: true

metaM coa c
initial concentration: 1.0
constant: false
is: HMDB01423
initial amount: NaN
boundary condition: false
is: CHEBI:3312
is: SBO:0000247
notes: FORMULA: C21H32N7O16P3S CHARGE: -4
has only substance units: false
type: Species
is: C00010
name: Coenzyme A

metaR r1421
product: MODEL1310110042#
name: Free diffusion
kinetic law: MODEL1310110042#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: 4.2.1.1 Confidence Level: 0 AUTHORS: PMID:10938543,PMID:11493685,PMID:12713833,PMID:12747791,PMID:14640555,PMID:17259996,PMID:17504134,PMID:17826101,PMID:7011879,PMID:7672338 NOTES:
fast: false
reversible: true
is: SBO:0000185
reactant: MODEL1310110042#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110042#_c3017807_412c_4abe_a657_43dc60891eea
type: Species
name: GMPPB
has only substance units: false
initial concentration: NaN
boundary condition: true
is encoded by: hsa:29925
is: SBO:0000252
initial amount: NaN
is: Q9Y5P6
constant: false

http://identifiers.org/biomodels.db/MODEL1310110042#_fe9b3455_4947_4e3a_9826_62e34413cd93
is: SBO:0000252
is: Q7LGC8
initial amount: NaN
boundary condition: true
type: Species
constant: false
name: CHST3
has only substance units: false
is encoded by: hsa:9469
initial concentration: NaN

metaR SERDGLYexR
is described by: ECO:0000304
reactant: MODEL1310110042#
name: D-Serine/Glycine reversible exchange
modifier: MODEL1310110042#
fast: false
notes: GENE_ASSOCIATION: (56301.1) and (6520.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10734121,PMID:10863037,PMID:14770310 NOTES:
kinetic law: MODEL1310110042#
product: MODEL1310110042#
is: SBO:0000185
reversible: true
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110042#_800f454d_6c57_4cb1_bbc5_4787bec4f989
type: Species
boundary condition: true
initial concentration: NaN
is: P14415
constant: false
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:482
has only substance units: false
name: ATP1B2

metaR GGH 6THFe
kinetic law: MODEL1310110042#
product: MODEL1310110042#
fast: false
modifier: MODEL1310110042#
is version of: http://identifiers.org/ec-code/3.4.19.9
reversible: false
is described by: ECO:0000000
is: SBO:0000176
name: Gamma-glutamyl hydrolase (6THF), extracellular
notes: GENE_ASSOCIATION: (8836.1) SUBSYSTEM: Folate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:11375437,PMID:2867095,PMID:9614206 NOTES:REMOVES EITHER ONE OR TWO GLUTAMYL RESIDUES WITH A REACTION (WILL ONLY REPRESENT 1) IT
reactant: MODEL1310110042#
type: Reaction

metaR SERTHRNaEx
fast: false
type: Reaction
reactant: MODEL1310110042#
modifier: MODEL1310110042#
product: MODEL1310110042#
kinetic law: MODEL1310110042#
is described by: ECO:0000269
reversible: false
name: L-serine/L-threonine Na-dependent exchange (Ser-L in)
is: SBO:0000185
notes: GENE_ASSOCIATION: (6509.1) or (6510.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14530974 NOTES:SAB see Kanai and Hediger 2004 (2003), PMID 14530974

http://identifiers.org/biomodels.db/MODEL1310110042#_d8d82bbd_fb0e_4650_9a97_060ddc204e4a
boundary condition: true
initial amount: NaN
type: Species
constant: false
has only substance units: false
is: SBO:0000252
name: CA5B
is encoded by: hsa:11238
is: Q9Y2D0
initial concentration: NaN

metaM g3m8mpdol L r
initial concentration: 1.0
boundary condition: false
initial amount: NaN
name: (alpha-D-Glucosyl)3-(alpha-D-mannosyl)8-beta-D-mannosyl-diacetylchitobiosyldiphosphodolichol, human liver homolog
is: C00459
is: HMDB01342
has only substance units: false
is: CHEBI:37568
type: Species
constant: false
notes: FORMULA: C1960H3228N20O770P20 CHARGE: -20
is: SBO:0000247

metaR r1597
is: SBO:0000185
type: Reaction
reversible: true
reactant: MODEL1310110042#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
kinetic law: MODEL1310110042#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
fast: false
product: MODEL1310110042#
is described by: ECO:0000000

metaR r2117
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
product: MODEL1310110042#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
is described by: ECO:0000000
kinetic law: MODEL1310110042#
is: SBO:0000185
modifier: MODEL1310110042#
reactant: MODEL1310110042#
fast: false
type: Reaction
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110042#_c46c030d_667b_4abf_9b0a_74cc6c119862
has only substance units: false
type: Species
constant: false
boundary condition: true
is: SBO:0000252
is: Q16774
name: GUK1
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:2987

http://identifiers.org/biomodels.db/MODEL1310110042#_5aafb5ad_fa4c_44a2_80f7_afd063855448
boundary condition: true
initial concentration: NaN
type: Species
has only substance units: false
initial amount: NaN
is: P15291
name: B4GALT1
constant: false
is: SBO:0000252
is encoded by: hsa:2683

metaM decdicoa c
boundary condition: false
initial concentration: 1.0
notes: FORMULA: C31H46N7O17P3S CHARGE: -4
has only substance units: false
type: Species
constant: false
is: HMDB01168
is: SBO:0000247
name: decadienoylcoa
initial amount: NaN

metaR CERT2rt
is: SBO:0000185
fast: false
is described by: ECO:0000000
name: ceramide transport protein
notes: GENE_ASSOCIATION: (10087.1) SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: PMID:12803919,PMID:14685229,PMID:15596449,PMID:15907394 NOTES:non-vesicular intracellular transport of glucocerebroside
is version of: http://identifiers.org/ec-code/2.7.11.1
kinetic law: MODEL1310110042#
reversible: true
type: Reaction
reactant: MODEL1310110042#
product: MODEL1310110042#
modifier: MODEL1310110042#

metaM hedepecoa m
name: 2,4,7,10,13-hexadecapentenoylcoa
has only substance units: false
boundary condition: false
is: HMDB02288
is: SBO:0000247
initial concentration: 1.0
constant: false
initial amount: NaN
type: Species
notes: FORMULA: C37H52N7O17P3S CHARGE: -4

metaR sink pre prot LPAREN r RPAREN
kinetic law: MODEL1310110042#
reactant: MODEL1310110042#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: 2.4.99.9 Confidence Level: 1 AUTHORS: PMID:9822625 NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: glycophosphatidylinositol (GPI)-anchored protein precursor sink
type: Reaction

metaR ACETONEt2m
reactant: MODEL1310110042#
name: acetone mitochondrial transport via proton symport
is: SBO:0000185
reversible: true
notes: GENE_ASSOCIATION: (6566.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: NOTES:NCD
kinetic law: MODEL1310110042#
fast: false
modifier: MODEL1310110042#
type: Reaction
product: MODEL1310110042#
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110042#_2cfeab50_6193_4fa6_a6c9_80f3e399ed72
is: Q9NZK7
is: SBO:0000252
has only substance units: false
is encoded by: hsa:30814
initial concentration: NaN
boundary condition: true
initial amount: NaN
type: Species
constant: false
name: PLA2G2E

http://identifiers.org/biomodels.db/MODEL1310110042#_a9c823a7_0f2d_4c5f_90ad_99d93ff9af44
is: B8ZZR8
constant: false
type: Species
boundary condition: true
is encoded by: hsa:79017
is: SBO:0000252
name: GGCT
initial amount: NaN
initial concentration: NaN
has only substance units: false

metaR r2114
reversible: true
product: MODEL1310110042#
is: SBO:0000185
is described by: ECO:0000000
kinetic law: MODEL1310110042#
modifier: MODEL1310110042#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
reactant: MODEL1310110042#
type: Reaction
fast: false
name: Major Facilitator(MFS) TCDB:2.A.1.13.1

http://identifiers.org/biomodels.db/MODEL1310110042#_90909f9b_44fa_484b_bd83_d3178ffcc74b
name: ACAT1
initial concentration: NaN
boundary condition: true
type: Species
initial amount: NaN
constant: false
is: P24752
is encoded by: hsa:38
has only substance units: false
is: SBO:0000252

metaM CE5854 e
has only substance units: false
initial concentration: 1.0
is: SBO:0000247
is: HMDB02710
initial amount: NaN
boundary condition: false
is: CHEBI:27485
notes: FORMULA: C21H27O10 CHARGE: -1 INCHI: InChI=1/C21H28O10/c1-9-10(2)17-11(8-12(9)22)4-6-21(3,31-17)7-5-13(23)29-20-16(26)14(24)15(25)18(30-20)19(27)28/h8,14-16,18,20,22,24-26H,4-7H2,1-3H3,(H,27,28)/p-1/t14-,15+,16-,18-,20+,21?/m1/s1 EHMN_ABBREVIATION: CE5854
type: Species
name: gama-CEHC-glucuronide
constant: false

metaR G14T20g
fast: false
notes: GENE_ASSOCIATION: (8703.1) or (2683.1) or (8704.2) or (8704.1) or (9334.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.38 Confidence Level: 4 AUTHORS: PMID:10747980,PMID:12512857,PMID:1903938,PMID:3094506,PMID:3144273,PMID:9405390,PMID:9435216 NOTES:Keratan sulfate II biosynthesis NCD
is version of: http://identifiers.org/ec-code/2.4.1.22
name: beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase, Golgi
type: Reaction
modifier: MODEL1310110042#
product: MODEL1310110042#
reversible: false
reactant: MODEL1310110042#
is version of: http://identifiers.org/ec-code/2.4.1.90
kinetic law: MODEL1310110042#
is: SBO:0000176
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/2.4.1.38

metaM nad x
has only substance units: false
initial amount: NaN
is: http://identifiers.org/pubchem.compound/3305
constant: false
name: Nicotinamide adenine dinucleotide
type: Species
boundary condition: false
is: HMDB00902
is: C00003
is: SBO:0000247
initial concentration: 1.0
is: CHEBI:57540

http://identifiers.org/biomodels.db/MODEL1310110042#_5922b4d0_b228_4c6c_a5f8_4f6eb79b10c5
is: Q96T66
initial concentration: NaN
is encoded by: hsa:349565
name: NMNAT3
boundary condition: true
constant: false
has only substance units: false
initial amount: NaN
type: Species
is: SBO:0000252

metaM HC01602 c
is: SBO:0000247
constant: false
boundary condition: false
is: CHEBI:57454
notes: FORMULA: C20H21N7O7 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00212 EHMN_ABBREVIATION: C00234
is: C00234
initial amount: NaN
name: 10-Formyltetrahydrofolate
has only substance units: false
type: Species
initial concentration: 1.0

metaR r1594
reversible: true
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
product: MODEL1310110042#
is described by: ECO:0000000
type: Reaction
kinetic law: MODEL1310110042#
reactant: MODEL1310110042#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
fast: false

metaR EX anth LPAREN e RPAREN
kinetic law: MODEL1310110042#
reactant: MODEL1310110042#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: Exchange of anthranilate
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110042#_95b3fdfc_d160_45ce_92b4_5153848a9c1b
initial amount: NaN
constant: false
is: Q9NT06
initial concentration: NaN
boundary condition: true
type: Species
is encoded by: hsa:54511
name: HMGCLL1
is: SBO:0000252
has only substance units: false

metaM 2docopencoa x
has only substance units: false
initial amount: NaN
constant: false
initial concentration: 1.0
is: SBO:0000247
name: 2,7,10,13,16-docosapentenoylcoa
type: Species
notes: FORMULA: C43H64N7O17P3S CHARGE: -4
is: http://identifiers.org/pubchem.compound/24892790
boundary condition: false

metaR r2115
kinetic law: MODEL1310110042#
is described by: ECO:0000000
reversible: true
reactant: MODEL1310110042#
fast: false
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
is: SBO:0000185
modifier: MODEL1310110042#
type: Reaction
product: MODEL1310110042#

http://identifiers.org/biomodels.db/MODEL1310110042#_be954c89_76d0_4c5e_ac94_3df4a4ae4cde
initial concentration: NaN
initial amount: NaN
name: IDH1
is: SBO:0000252
has only substance units: false
is encoded by: hsa:3417
boundary condition: true
type: Species
is: O75874
constant: false

metaM ivcrn c
is: HMDB00688
type: Species
is: SBO:0000247
notes: FORMULA: C12H23NO4 CHARGE: 0
constant: false
has only substance units: false
name: isovaleryl carnitine
initial amount: NaN
boundary condition: false
initial concentration: 1.0

metaR 3SALATAim
reversible: false
product: MODEL1310110042#
is: SBO:0000176
name: 3-sulfino-alanine transaminase (irreversible), mitochondrial
modifier: MODEL1310110042#
type: Reaction
fast: false
is described by: ECO:0000304
is version of: http://identifiers.org/ec-code/2.6.1.1
kinetic law: MODEL1310110042#
reactant: MODEL1310110042#
notes: GENE_ASSOCIATION: (2806.1) SUBSYSTEM: Methionine and cysteine metabolism EC Number: 2.6.1.1 Confidence Level: 2 AUTHORS: PMID:3346220 NOTES:MM. activity measured in rat, 3-sulfinoalanine is substrate found in human brain

metaM udpglcur c
is: SBO:0000247
is: C00167
is: CHEBI:58052
type: Species
constant: false
notes: FORMULA: C15H19N2O18P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00162 EHMN_ABBREVIATION: C00167
is: HMDB00935
boundary condition: false
name: UDP-D-glucuronate
initial concentration: 1.0
initial amount: NaN
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110042#_25985fd4_b084_40fc_8b75_397d5fa707d3
is: SBO:0000252
initial amount: NaN
constant: false
is: Q96H96
initial concentration: NaN
has only substance units: false
type: Species
name: COQ2
is encoded by: hsa:27235
boundary condition: true

metaM 3hibutcoa m
is: SBO:0000247
constant: false
boundary condition: false
is: CHEBI:28259
initial amount: NaN
name: (S)-3-Hydroxyisobutyryl-CoA
initial concentration: 1.0
notes: FORMULA: C25H38N7O18P3S CHARGE: -4 INCHI: InChI=1S/C25H42N7O18P3S/c1-13(8-33)24(38)54-7-6-27-15(34)4-5-28-22(37)19(36)25(2,3)10-47-53(44,45)50-52(42,43)46-9-14-18(49-51(39,40)41)17(35)23(48-14)32-12-31-16-20(26)29-11-30-21(16)32/h11-14,17-19,23,33,35-36H,4-10H2,1-3H3,(H,27,34)(H,28,37)(H,42,43)(H,44,45)(H2,26,29,30)(H2,39,40,41)/t13-,14+,17+,18+,19-,23+/m0/s1 EHMN_ABBREVIATION: C06000
has only substance units: false
is: HMDB01052
type: Species

metaR r0497
is version of: http://identifiers.org/ec-code/1.2.4.2
is described by: ECO:0000000
is: SBO:0000176
reactant: MODEL1310110042#
notes: GENE_ASSOCIATION: (4967.1) or (55753.1) SUBSYSTEM: Pyrimidine catabolism EC Number: 3.6.1.39 Confidence Level: 0 AUTHORS: PMID:1320895,PMID:6097526,PMID:6297538 NOTES:
product: MODEL1310110042#
name: dTTP nucleotidohydrolase Pyrimidine metabolism EC:3.6.1.39
kinetic law: MODEL1310110042#
reversible: true
fast: false
type: Reaction
modifier: MODEL1310110042#

metaR SPODMn
is version of: http://identifiers.org/ec-code/1.15.1.1
notes: GENE_ASSOCIATION: (6647.1) SUBSYSTEM: ROS detoxification EC Number: 1.15.1.1 Confidence Level: 4 AUTHORS: PMID:1332049,PMID:3889846 NOTES:JLR
modifier: MODEL1310110042#
is described by: ECO:0000269
kinetic law: MODEL1310110042#
type: Reaction
reactant: MODEL1310110042#
product: MODEL1310110042#
is: SBO:0000176
name: superoxide dismutase, nuclear
fast: false
reversible: false

metaM hs deg6 l
is: SBO:0000247
constant: false
initial amount: NaN
notes: FORMULA: C67H98N4O83S9 CHARGE: -10
initial concentration: 1.0
is: CHEBI:17180
has only substance units: false
name: heparan sulfate, degradation product 6
boundary condition: false
type: Species
is: HMDB01352

metaM succ x
type: Species
initial concentration: 1.0
constant: false
is: SBO:0000247
is: C00042
name: Succinate
is: HMDB00254
has only substance units: false
boundary condition: false
initial amount: NaN
notes: FORMULA: C4H4O4 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00049 EHMN_ABBREVIATION: C00042
is: CHEBI:30031

http://identifiers.org/biomodels.db/MODEL1310110042#_3482a3ea_be45_40a2_9cb1_b28ab69e1994
name: OXSM
constant: false
has only substance units: false
is: SBO:0000252
initial amount: NaN
is: Q9NWU1
initial concentration: NaN
is encoded by: hsa:54995
type: Species
boundary condition: true

metaR r1595
reactant: MODEL1310110042#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
fast: false
type: Reaction
is: SBO:0000185
product: MODEL1310110042#
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is described by: ECO:0000000
kinetic law: MODEL1310110042#

http://identifiers.org/biomodels.db/MODEL1310110042#_c3c43bcc_9e7c_499c_a9a0_b097adacaf5d
boundary condition: true
initial concentration: NaN
has only substance units: false
type: Species
is encoded by: hsa:1350
initial amount: NaN
is: P15954
constant: false
name: COX7C
is: SBO:0000252

metaM xan c
notes: FORMULA: C5H4N4O2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00320 EHMN_ABBREVIATION: C00385
initial concentration: 1.0
is: SBO:0000247
name: Xanthine
is: CHEBI:17712
boundary condition: false
is: HMDB00292
type: Species
is: C00385
has only substance units: false
constant: false
initial amount: NaN

metaR ICDHyrm
is described by: ECO:0000269
kinetic law: MODEL1310110042#
modifier: MODEL1310110042#
notes: GENE_ASSOCIATION: (3418.1) SUBSYSTEM: Citric acid cycle EC Number: 1.1.1.42 Confidence Level: 4 AUTHORS: PMID:12234803,PMID:8187868 NOTES:The reaction may be reversible. Strathern shows the reaction as irreversible. IF
reactant: MODEL1310110042#
name: Isocitrate dehydrogenase (NADP+)
is version of: http://identifiers.org/ec-code/1.1.1.42
type: Reaction
is: SBO:0000176
reversible: true
product: MODEL1310110042#
fast: false

metaM CE5125 x
has only substance units: false
is: SBO:0000247
is: HMDB00127
is: CHEBI:15748
constant: false
type: Species
boundary condition: false
initial amount: NaN
notes: FORMULA: C40H68N7O17P3S CHARGE: -4 INCHI: InChI=1/C40H72N7O17P3S/c1-25(2)11-8-12-26(3)13-9-14-27(4)15-10-16-28(5)39(52)68-20-19-42-30(48)17-18-43-37(51)34(50)40(6,7)22-61-67(58,59)64-66(56,57)60-21-29-33(63-65(53,54)55)32(49)38(62-29)47-24-46-31-35(41)44-23-45-36(31)47/h23-29,32-34,38,49-50H,8-22H2,1-7H3,(H,42,48)(H,43,51)(H,56,57)(H,58,59)(H2,41,44,45)(H2,53,54,55)/p-4/t26-,27-,28-,29-,32+,33+,34u,38-/m0/s1 EHMN_ABBREVIATION: CE5125
name: (2S)-pristanoyl-CoA
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110042#_d056c5a8_6e78_4cb3_ac4a_a9689e6270d4
has only substance units: false
constant: false
is: P80365
initial amount: NaN
type: Species
is encoded by: hsa:3291
boundary condition: true
is: SBO:0000252
initial concentration: NaN
name: HSD11B2

metaR EX octa LPAREN e RPAREN
kinetic law: MODEL1310110042#
reactant: MODEL1310110042#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for octanoate (n-C8:0)
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110042#_fbb08d03_1936_4df8_9bf1_ec3b534d91d6
boundary condition: true
constant: false
is encoded by: hsa:3032
initial amount: NaN
name: HADHB
initial concentration: NaN
is: SBO:0000252
is: P55084
type: Species
has only substance units: false

metaR ASNGLNNaEx
modifier: MODEL1310110042#
is described by: ECO:0000269
product: MODEL1310110042#
reactant: MODEL1310110042#
kinetic law: MODEL1310110042#
reversible: false
name: L-glutamine/L-asparagine Na-dependent exchange (Asn-L in)
type: Reaction
is: SBO:0000185
fast: false
notes: GENE_ASSOCIATION: (6510.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14530974 NOTES:SAB see Kanai and Hediger 2004 (2003), PMID 14530974

metaM c81coa c
type: Species
initial concentration: 1.0
notes: FORMULA: C29H44N7O17P3S CHARGE: -4
constant: false
initial amount: NaN
is: C05276
is: SBO:0000247
is: HMDB03949
has only substance units: false
boundary condition: false
name: octenoylcoa

http://identifiers.org/biomodels.db/MODEL1310110042#_7356994d_aa8a_4ec9_a147_bf183629d870
type: Species
initial amount: NaN
boundary condition: true
has part: P48736
has only substance units: false
name: HCST:PIK3CG
is encoded by: hsa:5294
has part: Q9UBK5
constant: false
initial concentration: NaN
is encoded by: hsa:10870
is: SBO:0000297

metaM docosahexcoa m
boundary condition: false
initial concentration: 1.0
notes: FORMULA: C43H62N7O17P3S CHARGE: -4
initial amount: NaN
is: SBO:0000247
type: Species
name: 3,7,10,13,16,19-docosahexenoylcoa
has only substance units: false
is: http://identifiers.org/pubchem.compound/24892790
constant: false

metaR PROt4 2 r
modifier: MODEL1310110042#
product: MODEL1310110042#
kinetic law: MODEL1310110042#
reactant: MODEL1310110042#
fast: false
reversible: true
type: Reaction
notes: GENE_ASSOCIATION: (6534.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12719981 NOTES:SAB
is described by: ECO:0000006
is: SBO:0000185
name: Proline transport (sodium symport) (2:1)

metaR 13DAMPPOX
fast: false
reversible: false
modifier: MODEL1310110042#
is version of: http://identifiers.org/ec-code/1.4.3.22
product: MODEL1310110042#
reactant: MODEL1310110042#
notes: GENE_ASSOCIATION: (8639.1) or (26.1) or (314.2) or (314.1) SUBSYSTEM: beta-Alanine metabolism EC Number: 1.4.3.6 Confidence Level: 1 AUTHORS: PMID:15035803,PMID:8920635,PMID:9653080 NOTES:SAB
is version of: http://identifiers.org/ec-code/1.4.3.21
type: Reaction
is described by: ECO:0000212
kinetic law: MODEL1310110042#
name: 1,3-Diaminopropane:oxygen oxidoreductase (deaminating)
is: SBO:0000176

metaR r1592
reversible: true
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
product: MODEL1310110042#
is: SBO:0000185
is described by: ECO:0000000
kinetic law: MODEL1310110042#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
type: Reaction
reactant: MODEL1310110042#

metaR FAOXC2242046m
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.3.99.3
name: Beta oxidation of long chain fatty acid
is version of: http://identifiers.org/ec-code/1.3.8.1
notes: GENE_ASSOCIATION: (34.1) or (35.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.74 Confidence Level: 4 AUTHORS: NOTES:_1 round beta ox peroxisomal (very long chain FA) c22:4,n-6 -> c20:4, n-6 - final '6' in abbreviation indicates omega6 FA 4 step FAO lumped for 2 rounds also includes EC 1.1.1.35, 1.1.1.211, 1.3.3.6, 4.2.1.17, 4.2.1.74 NJ
product: MODEL1310110042#
reactant: MODEL1310110042#
reversible: false
modifier: MODEL1310110042#
type: Reaction
kinetic law: MODEL1310110042#
fast: false
is described by: ECO:0000000

metaR VACCt
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11788354,PMID:12864740 NOTES:NJ
product: MODEL1310110042#
name: fatty acid transport via diffusion
type: Reaction
is: SBO:0000185
reversible: true
kinetic law: MODEL1310110042#
reactant: MODEL1310110042#
is described by: ECO:0000000

metaR r2112
type: Reaction
is described by: ECO:0000000
fast: false
kinetic law: MODEL1310110042#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
is: SBO:0000185
modifier: MODEL1310110042#
reactant: MODEL1310110042#
reversible: true
product: MODEL1310110042#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:

metaR SFCYSe
type: Reaction
fast: false
is: SBO:0000185
reactant: MODEL1310110042#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID: 2621485 NOTES:sulfocysteine is exfreted in urine
reversible: true
name: Exit of sulfocysteine into extra-cellular space
is described by: ECO:0000134
product: MODEL1310110042#
kinetic law: MODEL1310110042#

metaM 4ppcys m
name: N-[(R)-4-phosphonatopantothenoyl]-L-cysteinate(3-)
has only substance units: false
type: Species
notes: FORMULA: C12H20N2O9PS CHARGE: -3 INCHI: InChI=1S/C12H23N2O9PS/c1-12(2,6-23-24(20,21)22)9(16)10(17)13-4-3-8(15)14-7(5-25)11(18)19/h7,9,16,25H,3-6H2,1-2H3,(H,13,17)(H,14,15)(H,18,19)(H2,20,21,22)/p-3/t7-,9-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01276 EHMN_ABBREVIATION: C04352
is: HMDB01117
is: CHEBI:59458
initial amount: NaN
boundary condition: false
initial concentration: 1.0
is: SBO:0000247
constant: false

http://identifiers.org/biomodels.db/MODEL1310110042#_34afbef9_6650_4474_8e8a_cf8e7d6b9277
name: PDE9A
has only substance units: false
boundary condition: true
initial amount: NaN
is: SBO:0000252
is encoded by: hsa:5152
initial concentration: NaN
type: Species
constant: false

metaR C160CRNt
reversible: false
modifier: MODEL1310110042#
is: SBO:0000185
kinetic law: MODEL1310110042#
type: Reaction
fast: false
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (788.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: PMID:14598172 NOTES:TV
name: C160 transport into the mitochondria
product: MODEL1310110042#
reactant: MODEL1310110042#

metaR r2113
type: Reaction
reversible: true
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
is described by: ECO:0000000
reactant: MODEL1310110042#
fast: false
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
modifier: MODEL1310110042#
product: MODEL1310110042#
kinetic law: MODEL1310110042#
is: SBO:0000185

metaM hLkynr c
constant: false
is: SBO:0000247
type: Species
boundary condition: false
name: 3-hydroxy-L-kynurenine
notes: FORMULA: C10H12N2O4 CHARGE: 0 INCHI: InChI=1S/C10H12N2O4/c11-6(10(15)16)4-8(14)5-2-1-3-7(13)9(5)12/h1-3,6,13H,4,11-12H2,(H,15,16)/t6-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01079 EHMN_ABBREVIATION: C03227
has only substance units: false
initial amount: NaN
initial concentration: 1.0
is: CHEBI:17380
is: HMDB11631

metaR EX 10fthf LPAREN e RPAREN
kinetic law: MODEL1310110042#
reactant: MODEL1310110042#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 10-Formyltetrahydrofolate exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110042#_eba5b18f_15aa_4217_ba01_90dbaef69923
boundary condition: true
name: NDUFB8
is: O95169
initial amount: NaN
has only substance units: false
is: SBO:0000252
initial concentration: NaN
type: Species
constant: false
is encoded by: hsa:4714

metaR O16G2e
name: oligo-1,6-glucosidase (strch2 ->strch3), extracellular
product: MODEL1310110042#
kinetic law: MODEL1310110042#
reversible: false
reactant: MODEL1310110042#
is version of: http://identifiers.org/ec-code/3.2.1.10
modifier: MODEL1310110042#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (6476.1) SUBSYSTEM: Starch and sucrose metabolism EC Number: 3.2.1.10 Confidence Level: 0 AUTHORS: NOTES:NCD
fast: false
type: Reaction
is: SBO:0000176

metaM CE0785 m
is: SBO:0000247
has only substance units: false
constant: false
is: CHEBI:57795
name: cis,cis-myristo-5,8-dienoyl-CoA
boundary condition: false
type: Species
initial concentration: 1.0
notes: FORMULA: C35H54N7O17P3S CHARGE: -4 INCHI: InChI=1/C35H58N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-26(44)63-19-18-37-25(43)16-17-38-33(47)30(46)35(2,3)21-56-62(53,54)59-61(51,52)55-20-24-29(58-60(48,49)50)28(45)34(57-24)42-23-41-27-31(36)39-22-40-32(27)42/h8-9,11-12,22-24,28-30,34,45-46H,4-7,10,13-21H2,1-3H3,(H,37,43)(H,38,47)(H,51,52)(H,53,54)(H2,36,39,40)(H2,48,49,50)/p-4/b9-8-,12-11-/t24-,28+,29+,30u,34-/m0/s1 EHMN_ABBREVIATION: CE0785
initial amount: NaN

metaR PYNP2r
type: Reaction
product: MODEL1310110042#
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/2.4.2.3
reactant: MODEL1310110042#
fast: false
kinetic law: MODEL1310110042#
name: pyrimidine-nucleoside phosphorylase (uracil)
notes: GENE_ASSOCIATION: (7378.2) or (151531.1) or (7378.1) SUBSYSTEM: Pyrimidine catabolism EC Number: 2.4.2.2 Confidence Level: 4 AUTHORS: PMID:11278417,PMID:12084455,PMID:12849978,PMID:7488099 NOTES:JLR- added reversible form of PYNP2
is: SBO:0000176
modifier: MODEL1310110042#
reversible: true

metaR EX c6crn
kinetic law: MODEL1310110042#
reactant: MODEL1310110042#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for hexanoyl carnitine
type: Reaction

metaM galside hs g
constant: false
initial concentration: 1.0
is: CHEBI:12947
notes: FORMULA: C24H46NO7FULLRCO CHARGE: 0 EHMN_ABBREVIATION: C02686
name: D-galactosyl-N-acylsphingosine
boundary condition: false
is: SBO:0000247
initial amount: NaN
type: Species
has only substance units: false

metaR G6Pter
reactant: MODEL1310110042#
type: Reaction
fast: false
kinetic law: MODEL1310110042#
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (2542.1) SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 4 AUTHORS: PMID:11032333,PMID:11140953,PMID:11879177,PMID:9428641 NOTES:NCD
modifier: MODEL1310110042#
is: SBO:0000185
name: glucose 6-phosphate endoplasmic reticular transport via diffusion
product: MODEL1310110042#
reversible: true

metaR r1593
is described by: ECO:0000000
reactant: MODEL1310110042#
fast: false
product: MODEL1310110042#
type: Reaction
is: SBO:0000185
reversible: true
kinetic law: MODEL1310110042#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1

metaM ivcrn e
name: isovaleryl carnitine
boundary condition: false
initial concentration: 1.0
has only substance units: false
notes: FORMULA: C12H23NO4 CHARGE: 0
is: SBO:0000247
type: Species
constant: false
is: HMDB00688
initial amount: NaN

metaM vacccoa m
has only substance units: false
is: http://identifiers.org/pubchem.compound/9543677
name: vaccenyl coenzyme A
initial amount: NaN
is: HMDB06521
initial concentration: 1.0
notes: FORMULA: C39H64N7O17P3S CHARGE: -4 INCHI: InChI=1/C39H68N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-30(48)67-23-22-41-29(47)20-21-42-37(51)34(50)39(2,3)25-60-66(57,58)63-65(55,56)59-24-28-33(62-64(52,53)54)32(49)38(61-28)46-27-45-31-35(40)43-26-44-36(31)46/h9-10,26-28,32-34,38,49-50H,4-8,11-25H2,1-3H3,(H,41,47)(H,42,51)(H,55,56)(H,57,58)(H2,40,43,44)(H2,52,53,54)/b10-9+/t28-,32-,33?,34+,38-/m1/s1
is: SBO:0000247
boundary condition: false
constant: false
type: Species

metaM ile L m
is: CHEBI:17191
constant: false
initial concentration: 1.0
type: Species
notes: FORMULA: C6H13NO2 CHARGE: 0 INCHI: InChI=1S/C6H13NO2/c1-3-4(2)5(7)6(8)9/h4-5H,3,7H2,1-2H3,(H,8,9)/t4-,5-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00334 EHMN_ABBREVIATION: C00407
boundary condition: false
is: HMDB00172
initial amount: NaN
is: SBO:0000247
name: L-isoleucine
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110042#_ef70f80e_3e94_4d19_97f6_c7ba2b67ac91
initial concentration: NaN
has only substance units: false
is encoded by: hsa:2517
boundary condition: true
constant: false
is: P04066
name: FUCA1
initial amount: NaN
type: Species
is: SBO:0000252

metaM cdp e
is: HMDB01546
has only substance units: false
is: CHEBI:58069
boundary condition: false
name: CDP(3-)
is: SBO:0000247
notes: FORMULA: C9H12N3O11P2 CHARGE: -3 INCHI: InChI=1S/C9H15N3O11P2/c10-5-1-2-12(9(15)11-5)8-7(14)6(13)4(22-8)3-21-25(19,20)23-24(16,17)18/h1-2,4,6-8,13-14H,3H2,(H,19,20)(H2,10,11,15)(H2,16,17,18)/p-3/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00110 EHMN_ABBREVIATION: C00112
initial concentration: 1.0
type: Species
constant: false
initial amount: NaN

metaR FACOAL244 1
is: SBO:0000176
reactant: MODEL1310110042#
product: MODEL1310110042#
type: Reaction
is version of: http://identifiers.org/ec-code/6.2.1.3
reversible: true
kinetic law: MODEL1310110042#
fast: false
modifier: MODEL1310110042#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (2180.1) SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 4 AUTHORS: PMID:15292367 NOTES:NJ
name: fatty-acid--CoA ligase

metaR RE2660N
product: MODEL1310110042#
is: SBO:0000176
kinetic law: MODEL1310110042#
type: Reaction
notes: GENE_ASSOCIATION: (5092.1) or (84105.1) SUBSYSTEM: Tetrahydrobiopterin metabolism EC Number: 4.2.1.96 Confidence Level: 0 AUTHORS: PMID:8921004 NOTES:
is version of: http://identifiers.org/ec-code/4.2.1.96
fast: false
modifier: MODEL1310110042#
name: RE2660
is described by: ECO:0000000
reversible: true
reactant: MODEL1310110042#

metaR MDHm
product: MODEL1310110042#
kinetic law: MODEL1310110042#
is version of: http://identifiers.org/ec-code/1.1.1.37
reactant: MODEL1310110042#
type: Reaction
modifier: MODEL1310110042#
is: SBO:0000176
notes: GENE_ASSOCIATION: (4191.1) SUBSYSTEM: Citric acid cycle EC Number: 1.1.1.37 Confidence Level: 0 AUTHORS: PMID:15565635,PMID:9933076 NOTES:IF. Biochemical
name: malate dehydrogenase, mitochondrial
fast: false
reversible: true
is described by: ECO:0000134

http://identifiers.org/biomodels.db/MODEL1310110042#_c308d35a_d171_4072_975d_024e24c92124
type: Species
is: P15121
boundary condition: true
is encoded by: hsa:231
has only substance units: false
initial amount: NaN
name: AKR1B1
is: SBO:0000252
initial concentration: NaN
constant: false

http://identifiers.org/biomodels.db/MODEL1310110042#_db3b09ba_fc9a_4572_a58b_44959b136011
initial concentration: NaN
is: SBO:0000252
initial amount: NaN
type: Species
constant: false
has only substance units: false
boundary condition: true
name: ST20
is encoded by: hsa:400410
is: Q9HBF5

http://identifiers.org/biomodels.db/MODEL1310110042#_a1bddbcb_67a0_48d5_bcef_b950f9b4920f
is: P56556
type: Species
boundary condition: true
name: NDUFA6
is encoded by: hsa:4700
initial concentration: NaN
is: SBO:0000252
has only substance units: false
constant: false
initial amount: NaN

metaM coa m
is: C00010
type: Species
has only substance units: false
notes: FORMULA: C21H32N7O16P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00020 EHMN_ABBREVIATION: C00010
name: Coenzyme A
is: SBO:0000247
boundary condition: false
initial concentration: 1.0
initial amount: NaN
is: CHEBI:57287
constant: false
is: HMDB01423

metaR FAOXC81C61m
kinetic law: MODEL1310110042#
product: MODEL1310110042#
reactant: MODEL1310110042#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C8:1-->C6:1)m
type: Reaction

metaR r1863
reactant: MODEL1310110042#
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
product: MODEL1310110042#
is: SBO:0000185
kinetic law: MODEL1310110042#
is described by: ECO:0000000
fast: false
modifier: MODEL1310110042#
type: Reaction
name: Y+LAT2 Utilized transport
reversible: false

metaR H2Otm
modifier: MODEL1310110042#
name: H2O transport, mitochondrial
fast: false
reversible: true
notes: GENE_ASSOCIATION: (343.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:15749715 NOTES:IF
is described by: ECO:0000269
type: Reaction
is: SBO:0000185
product: MODEL1310110042#
reactant: MODEL1310110042#
kinetic law: MODEL1310110042#

metaR ILEtec
notes: GENE_ASSOCIATION: (8501.1) or (124935.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12930836,PMID:14624363,PMID:15659399 NOTES:SAB
is: SBO:0000185
name: L-isoleucine transport via diffusion (extracellular to cytosol)
type: Reaction
fast: false
product: MODEL1310110042#
kinetic law: MODEL1310110042#
reversible: true
modifier: MODEL1310110042#
reactant: MODEL1310110042#
is described by: ECO:0000269

metaR FAOXC5C5OHm
kinetic law: MODEL1310110042#
product: MODEL1310110042#
reactant: MODEL1310110042#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C5-->C5OH)m
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110042#_1e1acb00_37f0_4114_8582_f28eeaa17cf7
type: Species
constant: false
is encoded by: hsa:2098
is: SBO:0000252
boundary condition: true
initial concentration: NaN
name: ESD
has only substance units: false
is: P10768
initial amount: NaN

metaR r1864
modifier: MODEL1310110042#
reactant: MODEL1310110042#
is: SBO:0000185
product: MODEL1310110042#
reversible: false
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is described by: ECO:0000000
fast: false
name: Y+LAT2 Utilized transport
type: Reaction
kinetic law: MODEL1310110042#

metaM phytcoa c
name: phytanoyl-CoA(4-)
initial amount: NaN
type: Species
initial concentration: 1.0
notes: FORMULA: C41H70N7O17P3S CHARGE: -4 INCHI: InChI=1S/C41H74N7O17P3S/c1-26(2)11-8-12-27(3)13-9-14-28(4)15-10-16-29(5)21-32(50)69-20-19-43-31(49)17-18-44-39(53)36(52)41(6,7)23-62-68(59,60)65-67(57,58)61-22-30-35(64-66(54,55)56)34(51)40(63-30)48-25-47-33-37(42)45-24-46-38(33)48/h24-30,34-36,40,51-52H,8-23H2,1-7H3,(H,43,49)(H,44,53)(H,57,58)(H,59,60)(H2,42,45,46)(H2,54,55,56)/p-4/t27?,28?,29?,30-,34-,35-,36+,40-/m1/s1
is: CHEBI:57391
is: HMDB01359
has only substance units: false
constant: false
is: SBO:0000247
boundary condition: false

metaM coa n
boundary condition: false
has only substance units: false
notes: FORMULA: C21H32N7O16P3S CHARGE: -4 INCHI: InChI=1S/C21H36N7O16P3S/c1-21(2,16(31)19(32)24-4-3-12(29)23-5-6-48)8-41-47(38,39)44-46(36,37)40-7-11-15(43-45(33,34)35)14(30)20(42-11)28-10-27-13-17(22)25-9-26-18(13)28/h9-11,14-16,20,30-31,48H,3-8H2,1-2H3,(H,23,29)(H,24,32)(H,36,37)(H,38,39)(H2,22,25,26)(H2,33,34,35)/p-4/t11-,14-,15-,16+,20-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00020 EHMN_ABBREVIATION: C00010
constant: false
is: HMDB01423
initial concentration: 1.0
type: Species
name: coenzyme A(4-)
initial amount: NaN
is: CHEBI:57287
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110042#_a109218c_2ff2_4744_a956_936a0b30b05a
initial concentration: NaN
is: Q02252
is encoded by: hsa:4329
initial amount: NaN
name: ALDH6A1
boundary condition: true
type: Species
constant: false
has only substance units: false
is: SBO:0000252

metaR H2Otn
is: SBO:0000185
reversible: true
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD
product: MODEL1310110042#
kinetic law: MODEL1310110042#
type: Reaction
is described by: ECO:0000000
reactant: MODEL1310110042#
name: H2O transport, nuclear

metaR r1167
is described by: ECO:0000000
is: SBO:0000176
name: EC:2.3.1.26
reversible: false
product: MODEL1310110042#
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 2.3.1.26 Confidence Level: 0 AUTHORS: PMID:2760547,PMID:7822296,PMID:9242919 NOTES:
reactant: MODEL1310110042#
kinetic law: MODEL1310110042#
type: Reaction
fast: false

metaR FAOXC225C226x
kinetic law: MODEL1310110042#
product: MODEL1310110042#
reactant: MODEL1310110042#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C22:5-->C22:6)x
type: Reaction

metaR THMMPtm
is: SBO:0000185
product: MODEL1310110042#
kinetic law: MODEL1310110042#
reactant: MODEL1310110042#
name: Thiamine monophosphate transport, mitochondrial
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: PMID:12014993,PMID:9755848 NOTES:IT
type: Reaction
reversible: true
is described by: ECO:0000000

metaM hs deg25 l
notes: FORMULA: C23H37O21 CHARGE: -1
initial concentration: 1.0
boundary condition: false
initial amount: NaN
has only substance units: false
type: Species
is: SBO:0000247
constant: false
name: GlcA-beta-1,3-Gal-beta-1,3-Gal-beta-1,4-Xylose
is: CHEBI:16126

metaM em2emgacpail hs r
is: SBO:0000247
initial amount: NaN
is: HMDB03125
initial concentration: 1.0
has only substance units: false
boundary condition: false
is: CHEBI:16240
notes: FORMULA: C53H100N3O35P3FULLRCO2FULLR2CO2 CHARGE: 0
type: Species
constant: false
name: (phosphoethanolaminyl-dimannosyl),(phosphoethanolaminyl)-mannosyl-glucosaminyl-acylphosphatidylinositol (H7)

metaM cdp c
initial amount: NaN
is: CHEBI:58069
is: HMDB01546
is: SBO:0000247
notes: FORMULA: C9H12N3O11P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00110 EHMN_ABBREVIATION: C00112
has only substance units: false
type: Species
is: C00112
boundary condition: false
constant: false
initial concentration: 1.0
name: CDP

metaM docohexcoa x
initial concentration: 1.0
is: SBO:0000247
boundary condition: false
has only substance units: false
type: Species
notes: FORMULA: C43H62N7O17P3S CHARGE: -4
is: http://identifiers.org/pubchem.compound/24892790
name: 2,4,7,10,13,16-docosahexenoylcoa
constant: false
initial amount: NaN

metaM strch2 e
boundary condition: false
is: HMDB00122
is: CHEBI:4167
constant: false
is: SBO:0000247
type: Species
initial amount: NaN
notes: FORMULA: C18H32O16 CHARGE: 0
name: starch, structure 2 (1,6-{2[1,4-Glc], [1,4-Glc]})
initial concentration: 1.0
has only substance units: false

metaM sl L e
initial concentration: 1.0
boundary condition: false
has only substance units: false
constant: false
is: SBO:0000247
is: CHEBI:61289
type: Species
initial amount: NaN
notes: FORMULA: C3H4O6S CHARGE: -2 INCHI: InChI=1S/C3H6O6S/c4-2(3(5)6)1-10(7,8)9/h2,4H,1H2,(H,5,6)(H,7,8,9)/p-2/t2-/m1/s1
name: (S)-3-sulfonatolactate(2-)

metaR AMPTASECG
reactant: MODEL1310110042#
reversible: false
name: alanyl aminopeptidase (cys-gly)
fast: false
is described by: ECO:0000212
is version of: http://identifiers.org/ec-code/3.4.11.2
kinetic law: MODEL1310110042#
modifier: MODEL1310110042#
is: SBO:0000176
type: Reaction
notes: GENE_ASSOCIATION: (290.1) SUBSYSTEM: Glutathione metabolism EC Number: 3.4.11.1 Confidence Level: 1 AUTHORS: PMID:12675513 NOTES:SAB. activity measured in cytosol rat liver; IT IS leucine aminopeptidase (EC3.4.11.1) NOT alanyl aminopeptidase EC3.4.11.2 which shows > 80% of the activity; sequence homology rat-human not yet verified; annotation 'extracellular' under B column ERROR
product: MODEL1310110042#

metaM naglc2p L c
initial amount: NaN
has only substance units: false
boundary condition: false
type: Species
name: N-Acetyl-D-glucosaminyldiphosphodolichol, human liver homolog
is: CHEBI:18278
constant: false
initial concentration: 1.0
is: SBO:0000247
notes: FORMULA: C1160H1898N10O120P20 CHARGE: -20 INCHI: InChI=1S/C33H59NO12P2/c1-23(2)12-8-13-24(3)14-9-15-25(4)16-10-17-26(5)18-11-19-27(6)20-21-43-47(39,40)46-48(41,42)45-33-30(34-28(7)36)32(38)31(37)29(22-35)44-33/h12,14,16,18,27,29-33,35,37-38H,8-11,13,15,17,19-22H2,1-7H3,(H,34,36)(H,39,40)(H,41,42)/b24-14+,25-16+,26-18-/t27?,29-,30-,31-,32-,33-/m1/s1

metaR NAt
name: sodium transport (uniport)
modifier: MODEL1310110042#
is: SBO:0000185
notes: GENE_ASSOCIATION: (6526.1) or (6523.1) or (6528.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10893432,PMID:11024018,PMID:11034615,PMID:12679487,PMID:12748858,PMID:1372904,PMID:15546855,PMID:2490366,PMID:7537337,PMID:7789985,PMID:8063771,PMID:8559252,PMID:8806637,PMID:9341168 NOTES:
fast: false
is described by: ECO:0000269
product: MODEL1310110042#
type: Reaction
kinetic law: MODEL1310110042#
reversible: true
reactant: MODEL1310110042#

http://identifiers.org/biomodels.db/MODEL1310110042#_b65386f2_6209_4016_be0d_0e3bf3b29c1d
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:10768
name: AHCYL1
boundary condition: true
constant: false
has only substance units: false
is: O43865
initial concentration: NaN
type: Species

metaR S6T11g
type: Reaction
reversible: false
name: galactose/N-acetylglucosamine 6-O-sulfotransferase, Golgi apparatus
reactant: MODEL1310110042#
modifier: MODEL1310110042#
notes: GENE_ASSOCIATION: (23563.2) or (9435.1) or (23563.1) or (10164.1) or (4166.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: Confidence Level: 4 AUTHORS: PMID:10330415,PMID:10491328,PMID:10913333,PMID:11278593,PMID:12403612,PMID:12855678,PMID:9722682 NOTES:NCD
product: MODEL1310110042#
is described by: ECO:0000000
kinetic law: MODEL1310110042#
is: SBO:0000176
fast: false

metaR TSTSTERONEt
is described by: ECO:0000269
reactant: MODEL1310110042#
is: SBO:0000185
fast: false
product: MODEL1310110042#
reversible: true
name: Testosterone transport
kinetic law: MODEL1310110042#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: 2.8.2.2 Confidence Level: 2 AUTHORS: PMID:1588921,PMID:16399349 NOTES:
type: Reaction

metaM hs deg4 l
is: SBO:0000247
constant: false
is: CHEBI:16126
initial concentration: 1.0
has only substance units: false
notes: FORMULA: C73H104N4O92S10 CHARGE: -12
boundary condition: false
type: Species
name: heparan sulfate, degradation product 4
initial amount: NaN

metaR RE0830N
modifier: MODEL1310110042#
is: SBO:0000176
product: MODEL1310110042#
is described by: ECO:0000000
kinetic law: MODEL1310110042#
fast: false
notes: GENE_ASSOCIATION: (5092.1) or (84105.1) SUBSYSTEM: Tetrahydrobiopterin metabolism EC Number: 4.2.1.96 Confidence Level: 0 AUTHORS: PMID:10727395,PMID:1355046,PMID:1988938 NOTES:
reactant: MODEL1310110042#
is version of: http://identifiers.org/ec-code/4.2.1.96
type: Reaction
name: RE0830
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110042#_38814835_6428_4154_9a33_35bb2e5b06c2
is encoded by: hsa:112
has only substance units: false
initial amount: NaN
initial concentration: NaN
is: SBO:0000252
name: ADCY6
boundary condition: true
constant: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110042#_9ca02e51_84b4_4242_b78b_e8659392f4b7
is encoded by: hsa:AA664770
constant: false
name: _AA664770_1_m
type: Species
initial amount: NaN
is: SBO:0000252
initial concentration: NaN
has only substance units: false
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110042#_4da4c824_5a56_45a4_b387_1b94a25eefaf
name: DGKB
initial concentration: NaN
is: SBO:0000252
boundary condition: true
type: Species
has only substance units: false
initial amount: NaN
constant: false
is: Q9Y6T7
is encoded by: hsa:1607

http://identifiers.org/biomodels.db/MODEL1310110042#_0bb810c3_7daf_4669_989e_5609aeaa2c4d
constant: false
initial concentration: NaN
name: GNS
boundary condition: true
initial amount: NaN
is encoded by: hsa:2799
is: Q7Z3X3
has only substance units: false
is: SBO:0000252
type: Species

metaM fprica c
is: C04734
notes: FORMULA: C10H13N4O9P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC01344 EHMN_ABBREVIATION: C04734
initial concentration: 1.0
type: Species
boundary condition: false
initial amount: NaN
constant: false
is: HMDB01439
is: CHEBI:58467
has only substance units: false
name: 5-Formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide
is: SBO:0000247

metaR DASCBR
fast: false
name: dehydroascorbate reductase
reactant: MODEL1310110042#
reversible: false
type: Reaction
notes: GENE_ASSOCIATION: (2745.1) or (51022.2) or (51022.1) SUBSYSTEM: Vitamin C metabolism EC Number: 1.6.5.4 Confidence Level: 4 AUTHORS: PMID:11297543 NOTES:
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/1.8.4.1
is: SBO:0000176
kinetic law: MODEL1310110042#
product: MODEL1310110042#
modifier: MODEL1310110042#

metaR FAOXC2452253x
product: MODEL1310110042#
is version of: http://identifiers.org/ec-code/4.2.1.107
kinetic law: MODEL1310110042#
notes: GENE_ASSOCIATION: (3295.1 and 30.1 and 51.2) or (30.1 and 51.2 and 1962.1) or (51.1 and 30.1 and 1962.1) or (51.1 and 3295.1 and 30.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.74 Confidence Level: 4 AUTHORS: NOTES:- in peroxisome, no fad, 1ste set of beta-ox is by acyl-coa oxidase (passes electrons directly to o2 -> h2o2) confusing name, sorry - accounting for omega3 vs omega6 FA peroxisomal (very long chain FA) c24:5,n-3 -> c22:5, n-3 4 step FAO lumped also includes EC 1.1.1.35, 1.1.1.211, 1.3.3.6, 4.2.1.17, 4.2.1.74 NJ
is version of: http://identifiers.org/ec-code/1.1.1.35
reversible: false
is version of: http://identifiers.org/ec-code/1.3.3.6
modifier: MODEL1310110042#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.3.1.16
name: Beta oxidation of long chain fatty acid
type: Reaction
reactant: MODEL1310110042#
is described by: ECO:0000000
fast: false

metaR EX omeprazole LPAREN e RPAREN
kinetic law: MODEL1310110042#
reactant: MODEL1310110042#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: omeprazole exchange
type: Reaction

metaM gpail hs c
initial concentration: 1.0
initial amount: NaN
name: 6-(alpha-D-glucosaminyl)-1-phosphatidyl-1D-myo-inositol
has only substance units: false
boundary condition: false
type: Species
is: CHEBI:17049
is: SBO:0000247
constant: false
notes: FORMULA: C15H28NO13PFULLRCO2FULLR2CO2 CHARGE: 0 EHMN_ABBREVIATION: C04248

metaR EX c4crn
kinetic law: MODEL1310110042#
reactant: MODEL1310110042#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for butyryl carnitine
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110042#_bdd09b8b_9f75_4bae_969d_1b9b659c9e0f
name: ACAA1
is: Q96CA6
initial amount: NaN
boundary condition: true
is encoded by: hsa:30
constant: false
has only substance units: false
initial concentration: NaN
type: Species
is: SBO:0000252

metaM coa l
initial amount: NaN
constant: false
notes: FORMULA: C21H32N7O16P3S CHARGE: -4 INCHI: InChI=1S/C21H36N7O16P3S/c1-21(2,16(31)19(32)24-4-3-12(29)23-5-6-48)8-41-47(38,39)44-46(36,37)40-7-11-15(43-45(33,34)35)14(30)20(42-11)28-10-27-13-17(22)25-9-26-18(13)28/h9-11,14-16,20,30-31,48H,3-8H2,1-2H3,(H,23,29)(H,24,32)(H,36,37)(H,38,39)(H2,22,25,26)(H2,33,34,35)/p-4/t11-,14-,15-,16+,20-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00020 EHMN_ABBREVIATION: C00010
type: Species
has only substance units: false
boundary condition: false
is: CHEBI:57287
initial concentration: 1.0
name: coenzyme A(4-)
is: HMDB01423
is: SBO:0000247

metaR MM8Ber
product: MODEL1310110042#
type: Reaction
modifier: MODEL1310110042#
name: mannosyl-oligosaccharide 1,2-alpha-mannosidase, endoplasmic reticulum
reactant: MODEL1310110042#
fast: false
is: SBO:0000176
is described by: ECO:0000000
kinetic law: MODEL1310110042#
reversible: false
is version of: http://identifiers.org/ec-code/3.2.1.113
notes: GENE_ASSOCIATION: (11253.1) SUBSYSTEM: N-glycan synthesis EC Number: 3.2.1.113 Confidence Level: 0 AUTHORS: PMID:10409699,PMID:9592125 NOTES:NCD

metaM s2l2n2m2m l
type: Species
initial concentration: 1.0
is: CHEBI:30825
constant: false
has only substance units: false
boundary condition: false
initial amount: NaN
name: de-Fuc form of PA6 (w/o peptide linkage)
is: HMDB00573
is: SBO:0000247
notes: FORMULA: C84H136N6O62 CHARGE: -2

metaR BALAtmr
kinetic law: MODEL1310110042#
product: MODEL1310110042#
is: SBO:0000185
fast: false
name: Beta-alanine reversible mitochondrial transport (diffusion)
reversible: true
reactant: MODEL1310110042#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 1 AUTHORS: PMID:15304357 NOTES:SAB
is described by: ECO:0000000
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110042#_f1421cdf_5fd6_4606_878a_d617730e0334
type: Species
is: SBO:0000252
initial concentration: NaN
name: GAMT
is encoded by: hsa:2593
initial amount: NaN
boundary condition: true
is: Q14353
constant: false
has only substance units: false

metaR CHOLESTle
notes: GENE_ASSOCIATION: (3988.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
reactant: MODEL1310110042#
kinetic law: MODEL1310110042#
reversible: false
type: Reaction
name: hydrolysis of cholesterol ester by cholesterol esterase
modifier: MODEL1310110042#
is version of: http://identifiers.org/ec-code/3.1.1.13
is described by: ECO:0000134
product: MODEL1310110042#
fast: false
is: SBO:0000176

metaR DPPS
fast: false
reversible: false
type: Reaction
kinetic law: MODEL1310110042#
reactant: MODEL1310110042#
is described by: ECO:0000134
is: SBO:0000176
product: MODEL1310110042#
name: decaprenyl synthase
notes: GENE_ASSOCIATION: SUBSYSTEM: Miscellaneous EC Number: Confidence Level: 2 AUTHORS: PMID:16262699 NOTES:by analogy to other dimethyl transferase rxns. See PMID: 10586494, human interemidate (from C15 ->C50) not explicitly determined yet, however it is known to occur since this pathway is essential in Q10 synthesis. For human metabolism: may be associated w/ GeneID: 23590 TPRT - recheck lit in future IT and NJ

metaR O2t
name: o2 transport (diffusion)
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 1 AUTHORS: NOTES:tv renamed from O2TP to O2t to avoid confusion with transport reaction from cytosol to peroxisome NCD
kinetic law: MODEL1310110042#
type: Reaction
reactant: MODEL1310110042#
reversible: true
product: MODEL1310110042#
fast: false
is described by: ECO:0000000
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110042#_c0aa4c2d_fc33_4c19_a033_de41fe0baddb
constant: false
is encoded by: hsa:10317
has only substance units: false
type: Species
name: B3GALT5
is: Q9Y2C3
initial concentration: NaN
boundary condition: true
is: SBO:0000252
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110042#_0931d110_cc7b_4eaa_84d8_0a0853e3fa3d
initial amount: NaN
initial concentration: NaN
type: Species
is: P07686
is encoded by: hsa:3074
has only substance units: false
boundary condition: true
name: HEXB
constant: false
is: SBO:0000252

metaR SRTNtu
kinetic law: MODEL1310110042#
product: MODEL1310110042#
notes: GENE_ASSOCIATION: (6580.1) or (6582.2) or (6582.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12883891 NOTES:SAB electrogenic, Na indepdendent & rev NJ
modifier: MODEL1310110042#
is described by: ECO:0000269
is: SBO:0000185
reactant: MODEL1310110042#
reversible: true
name: Serotonin uniport
type: Reaction
fast: false

metaR HDCEAtr
fast: false
name: fatty acid transport via diffusion
product: MODEL1310110042#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11788354,PMID:12864740 NOTES:NJ
is described by: ECO:0000000
kinetic law: MODEL1310110042#
reversible: true
type: Reaction
reactant: MODEL1310110042#

metaM hdcoa m
initial amount: NaN
has only substance units: false
boundary condition: false
constant: false
type: Species
name: Hexadecenoyl-CoA (n-C16:1CoA)
initial concentration: 1.0
notes: FORMULA: C37H60N7O17P3S CHARGE: -4
is: SBO:0000247
is: HMDB06532

http://identifiers.org/biomodels.db/MODEL1310110042#_415fad9c_4fb3_487c_9b7e_f2eb059a3400
constant: false
has only substance units: false
name: SLC24A4
type: Species
initial concentration: NaN
initial amount: NaN
boundary condition: true
is: SBO:0000252
is encoded by: hsa:123041

http://identifiers.org/biomodels.db/MODEL1310110042#_adf476e8_b89f_4adb_ba30_f373fbef3353
is: SBO:0000252
constant: false
name: IDH3G
initial concentration: NaN
boundary condition: true
initial amount: NaN
is: E9PDD5
type: Species
has only substance units: false
is encoded by: hsa:3421

metaR C16OHc
kinetic law: MODEL1310110042#
product: MODEL1310110042#
reactant: MODEL1310110042#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: production of 3-hydroxyhexadecanoylcarnitinec
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110042#_f01d6dcb_9b17_4171_bb3c_694666b14855
initial amount: NaN
has part: E7EX19
boundary condition: true
constant: false
type: Species
name: PIK3CD:PIK3R1
is: SBO:0000297
is encoded by: hsa:5295
initial concentration: NaN
has only substance units: false

metaM sl L c
type: Species
is: SBO:0000247
is: CHEBI:61289
constant: false
notes: FORMULA: C3H4O6S CHARGE: -2 INCHI: InChI=1S/C3H6O6S/c4-2(3(5)6)1-10(7,8)9/h2,4H,1H2,(H,5,6)(H,7,8,9)/p-2/t2-/m1/s1
name: (S)-3-sulfonatolactate(2-)
initial concentration: 1.0
boundary condition: false
has only substance units: false
initial amount: NaN

metaR TAURtcx
notes: GENE_ASSOCIATION: (6533.1) SUBSYSTEM: Taurine and hypotaurine metabolism EC Number: Confidence Level: 1 AUTHORS: PMID:8010975 NOTES:SAB
is: SBO:0000185
name: taurine transport (sodium symport) (cytosol to peroxisome)
fast: false
type: Reaction
modifier: MODEL1310110042#
is described by: ECO:0000212
kinetic law: MODEL1310110042#
reversible: true
reactant: MODEL1310110042#
product: MODEL1310110042#

http://identifiers.org/biomodels.db/MODEL1310110042#_3c1cf665_7a45_4fe2_b079_6a1e6023227e
initial concentration: NaN
has only substance units: false
boundary condition: true
name: PPA2
is: SBO:0000252
initial amount: NaN
type: Species
is: Q9H2U2
is encoded by: hsa:27068
constant: false

http://identifiers.org/biomodels.db/MODEL1310110042#_b22b9b58_f455_4f4f_b514_7f28578501c3
is: Q13057
type: Species
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:80347
is: SBO:0000252
has only substance units: false
name: COASY
constant: false
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110042#_61ae4b5a_ac8a_46aa_a56f_5cebd2ccee57
boundary condition: true
is: O14772
is: SBO:0000252
type: Species
initial amount: NaN
is encoded by: hsa:8790
constant: false
name: FPGT
initial concentration: NaN
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110042#_3f7d82dd_db2e_428b_b65b_f29c2b42de76
is: Q8TBG4
constant: false
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:64850
name: AGXT2L1
has only substance units: false
is: SBO:0000252
type: Species
boundary condition: true

metaM 2docohexecoa m
initial amount: NaN
name: 2,7,10,13,16,19-docosahexenoylcoa
boundary condition: false
notes: FORMULA: C43H62N7O17P3S CHARGE: -4
has only substance units: false
constant: false
initial concentration: 1.0
is: http://identifiers.org/pubchem.compound/24892790
type: Species
is: SBO:0000247

metaM nad n
name: NAD(1-)
is: CHEBI:57540
is: HMDB00902
is: SBO:0000247
initial concentration: 1.0
notes: FORMULA: C21H26N7O14P2 CHARGE: -1 INCHI: InChI=1S/C21H27N7O14P2/c22-17-12-19(25-7-24-17)28(8-26-12)21-16(32)14(30)11(41-21)6-39-44(36,37)42-43(34,35)38-5-10-13(29)15(31)20(40-10)27-3-1-2-9(4-27)18(23)33/h1-4,7-8,10-11,13-16,20-21,29-32H,5-6H2,(H5-,22,23,24,25,33,34,35,36,37)/p-1/t10-,11-,13-,14-,15-,16-,20-,21-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00013 EHMN_ABBREVIATION: C00003
initial amount: NaN
boundary condition: false
type: Species
constant: false
has only substance units: false

metaR FUMm
reactant: MODEL1310110042#
kinetic law: MODEL1310110042#
modifier: MODEL1310110042#
fast: false
notes: GENE_ASSOCIATION: (2271.1) SUBSYSTEM: Citric acid cycle EC Number: 4.2.1.2 Confidence Level: 0 AUTHORS: PMID:16774737,PMID:17111171,PMID:17111172 NOTES:IF. Biochemical
is: SBO:0000176
type: Reaction
is version of: http://identifiers.org/ec-code/4.2.1.2
product: MODEL1310110042#
is described by: ECO:0000134
reversible: true
name: fumarase, mitochondrial

metaM pa hs m
initial amount: NaN
has only substance units: false
type: Species
constant: false
name: phosphatidate(2-)
is: SBO:0000247
initial concentration: 1.0
boundary condition: false
notes: FORMULA: C3H5O4PFULLRCO2FULLR2CO2 CHARGE: -2 EHMN_ABBREVIATION: C00416
is: CHEBI:57739

metaR NRPPHRSULT
is: SBO:0000176
kinetic law: MODEL1310110042#
modifier: MODEL1310110042#
reactant: MODEL1310110042#
fast: false
notes: GENE_ASSOCIATION: (6818.1) or (6818.3) or (6818.2) SUBSYSTEM: Tyrosine metabolism EC Number: 2.8.2.1 Confidence Level: 4 AUTHORS: PMID:11535246,PMID:15293241 NOTES:RS/TV (6/14/05)
reversible: false
name: Norepinephrine Sulfotransferase
is described by: ECO:0000269
type: Reaction
product: MODEL1310110042#
is version of: http://identifiers.org/ec-code/2.8.2.1

metaM ksii core4 deg2 l
initial amount: NaN
has only substance units: false
is: HMDB00143
type: Species
initial concentration: 1.0
is: SBO:0000247
name: keratan sulfate II (core 4-linked), degradation product 2
boundary condition: false
constant: false
notes: FORMULA: C78H127N6O61S2X CHARGE: -2
is: CHEBI:12936

http://identifiers.org/biomodels.db/MODEL1310110042#_b470753c_cbc7_4ffe_b9d5_0cc5deacd042
boundary condition: true
initial concentration: NaN
name: DPM1
is: O60762
has only substance units: false
type: Species
constant: false
is encoded by: hsa:8813
is: SBO:0000252
initial amount: NaN

metaM 4ppan c
is: SBO:0000247
name: D-4'-Phosphopantothenate
is: HMDB01016
initial amount: NaN
boundary condition: false
is: C03492
has only substance units: false
is: CHEBI:10986
type: Species
notes: FORMULA: C9H15NO8P CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC01127 EHMN_ABBREVIATION: C03492
constant: false
initial concentration: 1.0

metaM ksi deg37 l
is: CHEBI:16953
is: SBO:0000247
constant: false
boundary condition: false
initial amount: NaN
type: Species
name: keratan sulfate I, degradation product 37
notes: FORMULA: C62H104N4O46 CHARGE: 0
has only substance units: false
initial concentration: 1.0
is: HMDB00812

metaR DOLPMT2 Ler
notes: GENE_ASSOCIATION: SUBSYSTEM: N-glycan synthesis EC Number: 2.4.1.130 Confidence Level: 0 AUTHORS: NOTES:
reversible: false
is: SBO:0000176
name: dolichyl-phosphate-mannose-glycolipid alpha-mannosyltransferase (liver)
is described by: ECO:0000000
fast: false
product: MODEL1310110042#
reactant: MODEL1310110042#
type: Reaction
kinetic law: MODEL1310110042#

metaM CE5121 m
is: SBO:0000247
notes: FORMULA: C31H48N7O17P3S CHARGE: -4 INCHI: InChI=1/C31H52N7O17P3S/c1-4-5-6-7-8-9-10-11-22(40)59-15-14-33-21(39)12-13-34-29(43)26(42)31(2,3)17-52-58(49,50)55-57(47,48)51-16-20-25(54-56(44,45)46)24(41)30(53-20)38-19-37-23-27(32)35-18-36-28(23)38/h9-10,18-20,24-26,30,41-42H,4-8,11-17H2,1-3H3,(H,33,39)(H,34,43)(H,47,48)(H,49,50)(H2,32,35,36)(H2,44,45,46)/p-4/b10-9+/t20-,24+,25+,26u,30-/m0/s1 EHMN_ABBREVIATION: CE5121
is: CHEBI:57449
initial concentration: 1.0
boundary condition: false
initial amount: NaN
constant: false
has only substance units: false
name: trans-3-decenoyl-CoA
type: Species

metaM Asn X Ser Thr r
is: SBO:0000247
initial concentration: 1.0
has only substance units: false
is: CHEBI:28938
constant: false
is: HMDB00051
type: Species
initial amount: NaN
name: protein-linked asparagine residue (N-glycosylation site)
notes: FORMULA: XH CHARGE: 0
boundary condition: false
is: C01342

metaR HACD1m
name: 3-hydroxyacyl-CoA dehydrogenase (acetoacetyl-CoA) (mitochondria)
is described by: ECO:0000134
kinetic law: MODEL1310110042#
product: MODEL1310110042#
is version of: http://identifiers.org/ec-code/4.2.1.17
type: Reaction
is version of: http://identifiers.org/ec-code/2.3.1.16
reactant: MODEL1310110042#
is version of: http://identifiers.org/ec-code/1.1.1.35
reversible: true
fast: false
is: SBO:0000176
notes: GENE_ASSOCIATION: (3028.1) or (3033.1) or (3030.1) and (3032.1) SUBSYSTEM: Tryptophan metabolism EC Number: 1.1.1.35 Confidence Level: 1 AUTHORS: PMID:17143551,PMID:17143552 NOTES:Same as EC 1.1.1.157 SAB mito. some physiological
modifier: MODEL1310110042#

metaR EX met L LPAREN e RPAREN
kinetic law: MODEL1310110042#
reactant: MODEL1310110042#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: L-Methionine exchange
type: Reaction

metaM 4ppcys c
notes: FORMULA: C12H20N2O9PS CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC01276 EHMN_ABBREVIATION: C04352
initial amount: NaN
initial concentration: 1.0
type: Species
is: HMDB01117
is: SBO:0000247
is: C04352
boundary condition: false
has only substance units: false
name: N-((R)-4-Phosphopantothenoyl)-L-cysteine
constant: false
is: CHEBI:59458

metaR FAOXTC122m
kinetic law: MODEL1310110042#
product: MODEL1310110042#
reactant: MODEL1310110042#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: isomerization trans(C12:2)m
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110042#_ff8d5c87_bc46_4626_a9dc_0fc270256865
initial concentration: NaN
is encoded by: hsa:84812
is: Q9BRC7
has only substance units: false
constant: false
initial amount: NaN
is: SBO:0000252
type: Species
name: PLCD4
boundary condition: true

metaR C3STDH1r
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.1.1.170
is described by: ECO:0000134
kinetic law: MODEL1310110042#
reactant: MODEL1310110042#
name: C-3 sterol dehydrogenase (4-methylzymosterol)
notes: GENE_ASSOCIATION: (50814.1) SUBSYSTEM: Cholesterol metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:12829805 NOTES:NCD ER version NJ
modifier: MODEL1310110042#
fast: false
product: MODEL1310110042#
reversible: false
type: Reaction

metaR FATP7t
modifier: MODEL1310110042#
reactant: MODEL1310110042#
type: Reaction
is: SBO:0000185
is version of: http://identifiers.org/ec-code/6.2.1.7
kinetic law: MODEL1310110042#
notes: GENE_ASSOCIATION: (10998.1) or (11001.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10479480,PMID:12856180,PMID:15522816 NOTES:electroneutral transport NJ
fast: false
product: MODEL1310110042#
is version of: http://identifiers.org/ec-code/6.2.1.3
is described by: ECO:0000000
reversible: true
name: fatty acid electroneutral transport

http://identifiers.org/biomodels.db/MODEL1310110042#_a14547b0_5d94_421d_a315_48c764a2a966
name: PTEN
is encoded by: hsa:5728
is: F6KD01
boundary condition: true
is: SBO:0000252
type: Species
initial amount: NaN
constant: false
has only substance units: false
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110042#_7122ae1f_128f_4372_98c5_329d7310c608
initial concentration: NaN
boundary condition: true
is: SBO:0000252
has only substance units: false
is: Q8WUM9
constant: false
name: SLC20A1
type: Species
is encoded by: hsa:6574
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110042#_66ee9500_a4a7_4991_b288_a0fb90bff933
type: Species
boundary condition: true
is encoded by: hsa:10005
has only substance units: false
name: ACOT8
initial amount: NaN
is: SBO:0000252
initial concentration: NaN
constant: false
is: O14734

metaM nad m
is: CHEBI:57540
is: http://identifiers.org/pubchem.compound/3305
boundary condition: false
initial amount: NaN
initial concentration: 1.0
is: HMDB00902
name: Nicotinamide adenine dinucleotide
is: SBO:0000247
constant: false
type: Species
is: C00003
has only substance units: false

metaM andrstrn r
is: HMDB00031
name: androsterone
type: Species
is: SBO:0000247
notes: FORMULA: C19H30O2 CHARGE: 0 INCHI: InChI=1S/C19H30O2/c1-18-9-7-13(20)11-12(18)3-4-14-15-5-6-17(21)19(15,2)10-8-16(14)18/h12-16,20H,3-11H2,1-2H3/t12-,13+,14-,15-,16-,18-,19-/m0/s1 EHMN_ABBREVIATION: C00523
initial concentration: 1.0
boundary condition: false
constant: false
has only substance units: false
is: CHEBI:16032
initial amount: NaN

metaM c101crn c
type: Species
notes: FORMULA: C17H31NO4 CHARGE: 0
constant: false
has only substance units: false
is: SBO:0000247
initial concentration: 1.0
is: HMDB13205
initial amount: NaN
name: decenoyl carnitine
boundary condition: false

metaM 3hexdtricoa m
name: 3,7,10-hexadecatrienoylcoa
boundary condition: false
type: Species
constant: false
has only substance units: false
notes: FORMULA: C37H56N7O17P3S CHARGE: -4
initial concentration: 1.0
is: HMDB02288
is: SBO:0000247
initial amount: NaN

metaM coa g
type: Species
is: SBO:0000247
has only substance units: false
initial concentration: 1.0
is: HMDB01423
initial amount: NaN
boundary condition: false
constant: false
is: CHEBI:57287
notes: FORMULA: C21H32N7O16P3S CHARGE: -4 INCHI: InChI=1S/C21H36N7O16P3S/c1-21(2,16(31)19(32)24-4-3-12(29)23-5-6-48)8-41-47(38,39)44-46(36,37)40-7-11-15(43-45(33,34)35)14(30)20(42-11)28-10-27-13-17(22)25-9-26-18(13)28/h9-11,14-16,20,30-31,48H,3-8H2,1-2H3,(H,23,29)(H,24,32)(H,36,37)(H,38,39)(H2,22,25,26)(H2,33,34,35)/p-4/t11-,14-,15-,16+,20-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00020 EHMN_ABBREVIATION: C00010
name: coenzyme A(4-)

metaR EX tetdec2crn
kinetic law: MODEL1310110042#
reactant: MODEL1310110042#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for tetradecadienoyl carnitine
type: Reaction

metaR H2Otg
kinetic law: MODEL1310110042#
reactant: MODEL1310110042#
reversible: true
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD
fast: false
name: H2O transport, Golgi apparatus
is described by: ECO:0000000
product: MODEL1310110042#
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110042#_5a04941c_3aad_4311_ab34_52757d66c66b
initial concentration: NaN
type: Species
is: SBO:0000297
boundary condition: true
is encoded by: hsa:3906
constant: false
has only substance units: false
initial amount: NaN
has part: P00709
name: B4GALT1:LALBA

http://identifiers.org/biomodels.db/MODEL1310110042#_10a00109_846d_4a11_a912_aaebff99b663
constant: false
boundary condition: true
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:6576
is: D9HTE9
name: SLC25A1
type: Species
initial amount: NaN
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110042#_4f5c0164_6779_4e30_8688_5322e17d5223
boundary condition: true
is: SBO:0000252
type: Species
constant: false
initial amount: NaN
is: Q14032
name: BAAT
has only substance units: false
initial concentration: NaN
is encoded by: hsa:570

http://identifiers.org/biomodels.db/MODEL1310110042#_613ee4da_75d2_4d03_8e58_7a508407b7b7
is: SBO:0000252
initial concentration: NaN
is: G3XA95
initial amount: NaN
constant: false
type: Species
has only substance units: false
boundary condition: true
is encoded by: hsa:8611
name: PPAP2A

http://identifiers.org/biomodels.db/MODEL1310110042#_165e7459_5fa4_4758_b04c_13622e89655c
has only substance units: false
type: Species
name: RPN1
is: SBO:0000252
initial amount: NaN
constant: false
initial concentration: NaN
boundary condition: true
is encoded by: hsa:6184
is: P04843

metaM HC01399 x
has only substance units: false
is: SBO:0000247
notes: FORMULA: C35H58N7O18P3S CHARGE: -4 INCHI: InChI=1S/C35H62N7O18P3S/c1-4-5-6-7-8-9-10-11-12-13-23(43)18-26(45)64-17-16-37-25(44)14-15-38-33(48)30(47)35(2,3)20-57-63(54,55)60-62(52,53)56-19-24-29(59-61(49,50)51)28(46)34(58-24)42-22-41-27-31(36)39-21-40-32(27)42/h21-24,28-30,34,43,46-47H,4-20H2,1-3H3,(H,37,44)(H,38,48)(H,52,53)(H,54,55)(H2,36,39,40)(H2,49,50,51)/t23-,24+,28+,29+,30-,34+/m0/s1 EHMN_ABBREVIATION: C05260
name: (S)-3-Hydroxytetradecanoyl-CoA
constant: false
initial amount: NaN
boundary condition: false
is: CHEBI:27466
type: Species
initial concentration: 1.0

metaR RE3524R
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Eicosanoid metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:9755286 NOTES:
name: RE3524
is described by: ECO:0000000
kinetic law: MODEL1310110042#
reactant: MODEL1310110042#
is: SBO:0000176
product: MODEL1310110042#
type: Reaction
fast: false

http://identifiers.org/biomodels.db/MODEL1310110042#_2a046b02_3f78_489f_9bcc_20d4ecd390f0
has only substance units: false
boundary condition: true
initial concentration: NaN
constant: false
type: Species
initial amount: NaN
is: SBO:0000252
name: PC
is encoded by: hsa:5091

metaM ksii core2 deg5 l
constant: false
is: HMDB00143
type: Species
initial concentration: 1.0
has only substance units: false
boundary condition: false
notes: FORMULA: C50H82N4O38SX CHARGE: -1
is: SBO:0000247
name: keratan sulfate II (core 2-linked), degradation product 5
initial amount: NaN
is: CHEBI:12936

http://identifiers.org/biomodels.db/MODEL1310110042#_de267aec_6b83_4191_992e_c7b4ee699926
constant: false
is: SBO:0000252
initial amount: NaN
has only substance units: false
name: _AA081045_1_e
type: Species
is encoded by: hsa:AA081045
boundary condition: true
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110042#_5e7ebab0_904c_48c1_ad7e_adc180ac3780
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:1719
has only substance units: false
is: SBO:0000252
type: Species
boundary condition: true
is: P00374
constant: false
name: DHFR

metaR SPODMx
product: MODEL1310110042#
type: Reaction
modifier: MODEL1310110042#
reactant: MODEL1310110042#
name: superoxide dismutase, peroxisome
kinetic law: MODEL1310110042#
is: SBO:0000176
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (6647.1) SUBSYSTEM: ROS detoxification EC Number: 1.15.1.1 Confidence Level: 4 AUTHORS: PMID:1332049,PMID:3889846 NOTES:JLR
fast: false
reversible: false
is version of: http://identifiers.org/ec-code/1.15.1.1

http://identifiers.org/biomodels.db/MODEL1310110042#_3f3c83fd_3114_4682_8e0a_b07174448929
is: Q9BX95
initial concentration: NaN
type: Species
name: SGPP1
is: SBO:0000252
constant: false
initial amount: NaN
is encoded by: hsa:81537
has only substance units: false
boundary condition: true

metaR EX atp LPAREN e RPAREN
kinetic law: MODEL1310110042#
reactant: MODEL1310110042#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: ATP exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110042#_e8ace0f4_2e78_4636_98c2_be5ab470da33
boundary condition: true
constant: false
is: SBO:0000252
has only substance units: false
initial amount: NaN
initial concentration: NaN
is: Q01959
name: SLC6A3
type: Species
is encoded by: hsa:6531

metaR r2538
type: Reaction
is described by: ECO:0000000
name: Utilized transport
fast: false
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:10049700,PMID:10574970,PMID:11389679,PMID:11557028,PMID:11564694,PMID:12824232,PMID:12930836,PMID:14574404,PMID:16288981,PMID:911815 NOTES:
reversible: true
product: MODEL1310110042#
reactant: MODEL1310110042#
kinetic law: MODEL1310110042#

metaR OCTDECCPT2
kinetic law: MODEL1310110042#
product: MODEL1310110042#
reactant: MODEL1310110042#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: transport of Octadecenoyl-CoA into mitochondrial matrix
type: Reaction

metaR FAOXC204C184m
kinetic law: MODEL1310110042#
product: MODEL1310110042#
reactant: MODEL1310110042#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C20:4-->C18:4)m
type: Reaction

metaR S6TASE13ly
fast: false
kinetic law: MODEL1310110042#
type: Reaction
is described by: ECO:0000000
is: SBO:0000176
modifier: MODEL1310110042#
product: MODEL1310110042#
reactant: MODEL1310110042#
reversible: true
name: N-acetylglucosamine-6-sulfatase, lysosomal
is version of: http://identifiers.org/ec-code/3.1.6.14
notes: GENE_ASSOCIATION: (2799.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.1.6.14 Confidence Level: 4 AUTHORS: PMID:3196333,PMID:3689314,PMID:3689315 NOTES:NCD

metaR C161CRNt
reversible: false
is: SBO:0000185
product: MODEL1310110042#
type: Reaction
notes: GENE_ASSOCIATION: (788.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: NOTES:TDV
fast: false
modifier: MODEL1310110042#
kinetic law: MODEL1310110042#
name: C161 transport into the mitochondria
reactant: MODEL1310110042#
is described by: ECO:0000000

metaM adp x
initial concentration: 1.0
initial amount: NaN
boundary condition: false
type: Species
is: HMDB01341
has only substance units: false
is: SBO:0000247
is: CHEBI:456216
notes: FORMULA: C10H12N5O10P2 CHARGE: -3 INCHI: InChI=1S/C10H15N5O10P2/c11-8-5-9(13-2-12-8)15(3-14-5)10-7(17)6(16)4(24-10)1-23-27(21,22)25-26(18,19)20/h2-4,6-7,10,16-17H,1H2,(H,21,22)(H2,11,12,13)(H2,18,19,20)/p-3/t4-,6-,7-,10-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00018 EHMN_ABBREVIATION: C00008
constant: false
name: ADP(3-)

metaR RTOTAL3FATPc
kinetic law: MODEL1310110042#
product: MODEL1310110042#
reactant: MODEL1310110042#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: uptake of Rtotal3 by enterocytes
type: Reaction

metaR PGLer
kinetic law: MODEL1310110042#
notes: GENE_ASSOCIATION: (9563.1) SUBSYSTEM: Pentose phosphate pathway EC Number: 3.1.1.31 Confidence Level: 4 AUTHORS: PMID:10349511,PMID:12831846,PMID:2156506 NOTES:SMP Net reaction same as described in Lehringer 334 NCD
reactant: MODEL1310110042#
type: Reaction
modifier: MODEL1310110042#
product: MODEL1310110042#
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/1.1.1.47
fast: false
name: 6-phosphogluconolactonase, endoplasmic reticulum
is: SBO:0000176
reversible: false

metaM ksii core2 pre5 g
name: keratan sulfate II biosynthesis, precursor 5
is: CHEBI:58053
initial concentration: 1.0
has only substance units: false
notes: FORMULA: C61H99N5O43X CHARGE: -1
is: SBO:0000247
is: HMDB00175
type: Species
initial amount: NaN
constant: false
boundary condition: false
is: C00130

http://identifiers.org/biomodels.db/MODEL1310110042#_157b0153_cc34_4df9_8412_387b5c77e6b5
is: SBO:0000252
initial concentration: NaN
boundary condition: true
name: SLC38A1
constant: false
is encoded by: hsa:81539
type: Species
is: Q9H2H9
has only substance units: false
initial amount: NaN

metaR EX leuktrB4 LPAREN e RPAREN
kinetic law: MODEL1310110042#
reactant: MODEL1310110042#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: leukotriene B4 exchange
type: Reaction

metaM Nacasp c
is: CHEBI:16953
notes: FORMULA: C6H7NO5 CHARGE: -2 INCHI: InChI=1S/C6H9NO5/c1-3(8)7-4(6(11)12)2-5(9)10/h4H,2H2,1H3,(H,7,8)(H,9,10)(H,11,12)/p-2/t4-/m0/s1 EHMN_ABBREVIATION: C01042
initial amount: NaN
is: SBO:0000247
has only substance units: false
boundary condition: false
constant: false
name: N-acetyl-L-aspartate(2-)
type: Species
initial concentration: 1.0
is: HMDB00812

http://identifiers.org/biomodels.db/MODEL1310110042#_405b1070_994a_4aba_b3a2_9401fb04df59
boundary condition: true
constant: false
type: Species
is encoded by: hsa:3420
has only substance units: false
initial amount: NaN
is: SBO:0000252
name: IDH3B
initial concentration: NaN

metaM dcdp c
is: C00705
is: HMDB01245
initial amount: NaN
is: CHEBI:58593
constant: false
notes: FORMULA: C9H12N3O10P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00506 EHMN_ABBREVIATION: C00705
is: SBO:0000247
has only substance units: false
name: dCDP
initial concentration: 1.0
boundary condition: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110042#_e6629752_b4a5_4d9a_9a08_57ca9210aaaa
boundary condition: true
has part: P51553
type: Species
is: SBO:0000297
has part: O43837
is encoded by: hsa:3421
initial concentration: NaN
is encoded by: hsa:3420
constant: false
has only substance units: false
name: IDH3A:IDH3B:IDH3G
initial amount: NaN

metaM sebacid c
name: sebacicacid
initial concentration: 1.0
has only substance units: false
initial amount: NaN
notes: FORMULA: C10H16O4 CHARGE: -2
constant: false
is: C08277
boundary condition: false
type: Species
is: SBO:0000247
is: HMDB00792

metaM cspg e e
is: HMDB00630
name: chondroitin sulfate E (GalNAc4,6diS-GlcA) proteoglycan
type: Species
constant: false
is: CHEBI:16040
initial amount: NaN
notes: FORMULA: C45H63N2O54S6X CHARGE: -8
is: SBO:0000247
initial concentration: 1.0
boundary condition: false
has only substance units: false

metaR r0752
type: Reaction
kinetic law: MODEL1310110042#
reversible: true
modifier: MODEL1310110042#
is: SBO:0000176
reactant: MODEL1310110042#
fast: false
product: MODEL1310110042#
notes: GENE_ASSOCIATION: (30.1) or (10449.1) or (3032.1) or (4645.1) SUBSYSTEM: Unassigned EC Number: 1.2.1.5 Confidence Level: 0 AUTHORS: PMID:10424772,PMID:11958479,PMID:3466164 NOTES:
is version of: http://identifiers.org/ec-code/2.3.1.16
name: 3,4-Dihydroxymandelaldehyde:NAD+ oxidoreductase Tyrosine metabolism EC:1.2.1.5
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110042#_a2e07834_d979_440c_8753_3fb7d4bc66fe
boundary condition: true
is encoded by: hsa:762
name: CA4
type: Species
is: Q6FHI7
is: SBO:0000252
initial concentration: NaN
initial amount: NaN
constant: false
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110042#_64ba293d_1bd2_4a54_89a7_262c8d654ff1
has only substance units: false
constant: false
boundary condition: true
type: Species
initial concentration: NaN
initial amount: NaN
is: SBO:0000252
name: COX3
is encoded by: hsa:4514
is: P00414

http://identifiers.org/biomodels.db/MODEL1310110042#_f0440623_3f10_408f_afee_e60983845f8a
is: P50443
boundary condition: true
initial concentration: NaN
constant: false
name: SLC26A2
is: SBO:0000252
has only substance units: false
is encoded by: hsa:1836
initial amount: NaN
type: Species

metaR HYXNt
notes: GENE_ASSOCIATION: (3177.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12006583,PMID:12838422 NOTES:tv
name: Hypoxanthine transport
fast: false
is described by: ECO:0000269
is: SBO:0000185
type: Reaction
kinetic law: MODEL1310110042#
reversible: true
reactant: MODEL1310110042#
modifier: MODEL1310110042#
product: MODEL1310110042#

metaM strdnc c
is: SBO:0000247
initial concentration: 1.0
initial amount: NaN
notes: FORMULA: C18H27O2 CHARGE: -1 INCHI: InChI=1/C18H28O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20/h3-4,6-7,9-10,12-13H,2,5,8,11,14-17H2,1H3,(H,19,20)/b4-3-,7-6-,10-9-,13-12- HEPATONET_1.0_ABBREVIATION: HC00793
boundary condition: false
name: stearidonic acid C18:4, n-3
type: Species
constant: false
is: http://identifiers.org/pubchem.compound/47205608
is: C16300
has only substance units: false
is: HMDB06547

metaR r2539
is: SBO:0000185
reactant: MODEL1310110042#
kinetic law: MODEL1310110042#
type: Reaction
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:10049700,PMID:10574970,PMID:11389679,PMID:11557028,PMID:11564694,PMID:12824232,PMID:12930836,PMID:14574404,PMID:16288981,PMID:911815 NOTES:
reversible: true
fast: false
product: MODEL1310110042#
name: Postulated transport reaction

metaM ttdca c
has only substance units: false
is: CHEBI:30807
initial concentration: 1.0
initial amount: NaN
boundary condition: false
name: myristate
notes: FORMULA: C14H27O2 CHARGE: -1 INCHI: InChI=1S/C14H28O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14(15)16/h2-13H2,1H3,(H,15,16)/p-1 EHMN_ABBREVIATION: C06424
type: Species
is: SBO:0000247
is: HMDB00806
constant: false

metaM lnlncacoa m
type: Species
initial concentration: 1.0
is: SBO:0000247
initial amount: NaN
has only substance units: false
constant: false
notes: FORMULA: C39H60N7O17P3S CHARGE: -4 INCHI: InChI=1S/C39H64N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-30(48)67-23-22-41-29(47)20-21-42-37(51)34(50)39(2,3)25-60-66(57,58)63-65(55,56)59-24-28-33(62-64(52,53)54)32(49)38(61-28)46-27-45-31-35(40)43-26-44-36(31)46/h5-6,8-9,11-12,26-28,32-34,38,49-50H,4,7,10,13-25H2,1-3H3,(H,41,47)(H,42,51)(H,55,56)(H,57,58)(H2,40,43,44)(H2,52,53,54)/b6-5-,9-8-,12-11-/t28-,32-,33-,34+,38-/m1/s1 EHMN_ABBREVIATION: CE4809
is: HMDB06290
boundary condition: false
name: alpha-Linolenoyl-CoA
is: CHEBI:51985

metaR CHOLt4
name: choline, sodium cotransport
type: Reaction
fast: false
notes: GENE_ASSOCIATION: (60482.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:11027560,PMID:11068039,PMID:12675135 NOTES:NCD
modifier: MODEL1310110042#
reversible: true
kinetic law: MODEL1310110042#
is described by: ECO:0000269
product: MODEL1310110042#
reactant: MODEL1310110042#
is: SBO:0000185

metaR EX pro L LPAREN e RPAREN
kinetic law: MODEL1310110042#
reactant: MODEL1310110042#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: L-Proline exchange
type: Reaction

metaR DMNONCOACRNCPT1
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 2 AUTHORS: PMID:9299016,PMID:9819701 NOTES:
product: MODEL1310110042#
fast: false
is: SBO:0000176
reactant: MODEL1310110042#
reversible: true
type: Reaction
name: DMNONCOACRNCPT1
kinetic law: MODEL1310110042#
is described by: ECO:0000000

metaR r0753
reversible: true
type: Reaction
is version of: http://identifiers.org/ec-code/2.3.1.85
product: MODEL1310110042#
is: SBO:0000176
kinetic law: MODEL1310110042#
modifier: MODEL1310110042#
reactant: MODEL1310110042#
notes: GENE_ASSOCIATION: (2194.1) SUBSYSTEM: Unassigned EC Number: 1.2.1.5 Confidence Level: 0 AUTHORS: PMID:11790142,PMID:12604221 NOTES:
fast: false
is described by: ECO:0000000
name: 3,4-Dihydroxymandelaldehyde:NADP+ oxidoreductase Tyrosine metabolism EC:1.2.1.5

metaM dhf m
notes: FORMULA: C19H19N7O6 CHARGE: -2 INCHI: InChI=1S/C19H21N7O6/c20-19-25-15-14(17(30)26-19)23-11(8-22-15)7-21-10-3-1-9(2-4-10)16(29)24-12(18(31)32)5-6-13(27)28/h1-4,12,21H,5-8H2,(H,24,29)(H,27,28)(H,31,32)(H4,20,22,25,26,30)/p-2/t12-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00340 EHMN_ABBREVIATION: C00415
is: SBO:0000247
initial amount: NaN
constant: false
is: CHEBI:57451
type: Species
initial concentration: 1.0
is: HMDB01056
has only substance units: false
boundary condition: false
name: dihydrofolate(2-)

metaR r0027
kinetic law: MODEL1310110042#
reactant: MODEL1310110042#
is version of: http://identifiers.org/ec-code/1.14.13.39
is: SBO:0000176
product: MODEL1310110042#
fast: false
modifier: MODEL1310110042#
name: NADPH:CoA-glutathione oxidoreductase EC:1.8.1.9
type: Reaction
is described by: ECO:0000000
reversible: true
notes: GENE_ASSOCIATION: (285973.1) or (D29675.1) or (4842.1) or (NOS2A.1) or (4846.1) SUBSYSTEM: Methionine and cysteine metabolism EC Number: 1.8.1.9 Confidence Level: 0 AUTHORS: PMID:18042542 NOTES:

metaM 13dpg c
name: 3-Phospho-D-glyceroyl phosphate
initial amount: NaN
is: CHEBI:57604
is: SBO:0000247
notes: FORMULA: C3H4O10P2 CHARGE: -4 INCHI: 1/C3H8O10P2/c4-2(1-12-14(6,7)8)3(5)13-15(9,10)11/h2,4H,1H2,(H2,6,7,8)(H2,9,10,11)/t2-/m1/s1/f/h6-7,9-10H HEPATONET_1.0_ABBREVIATION: HC00214 EHMN_ABBREVIATION: C00236
is: http://identifiers.org/pubchem.compound/3535
constant: false
type: Species
initial concentration: 1.0
boundary condition: false
is: C00236
is: HMDB01270
has only substance units: false

metaR GAO2g
modifier: MODEL1310110042#
product: MODEL1310110042#
reversible: false
reactant: MODEL1310110042#
is described by: ECO:0000269
name: Ganglioside O-acetylation
notes: GENE_ASSOCIATION: (9197.1) SUBSYSTEM: Sphingolipid metabolism EC Number: Confidence Level: 4 AUTHORS: NOTES:for humans - seq predicted SLC transporters have been found to have O-acetylation activity on gangliosides NJ
kinetic law: MODEL1310110042#
is: SBO:0000176
type: Reaction
fast: false

metaR FAOXC200180m
is described by: ECO:0000000
modifier: MODEL1310110042#
is version of: http://identifiers.org/ec-code/1.3.8.1
notes: GENE_ASSOCIATION: (35.1) or (34.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.74 Confidence Level: 4 AUTHORS: NOTES:c20:0 -> c18:0 4 step FAO lumped also includes EC 1.1.1.35, 1.1.1.211, 1.3.3.6, 4.2.1.17, 4.2.1.74 NJ
name: Beta oxidation of long chain fatty acid
product: MODEL1310110042#
reversible: false
kinetic law: MODEL1310110042#
type: Reaction
fast: false
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.3.99.3
reactant: MODEL1310110042#

metaR THRALANaEx
type: Reaction
is described by: ECO:0000269
reactant: MODEL1310110042#
reversible: false
kinetic law: MODEL1310110042#
fast: false
is: SBO:0000185
product: MODEL1310110042#
modifier: MODEL1310110042#
notes: GENE_ASSOCIATION: (6509.1) or (6510.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14530974 NOTES:SAB see Kanai and Hediger 2004 (2003), PMID 14530974
name: L-alanine/L-threonine Na-dependent exchange (Thr-L in)

metaM cholcoar x
has only substance units: false
notes: FORMULA: C48H76N7O20P3S CHARGE: -4 INCHI: InChI=1S/C48H80N7O20P3S/c1-25(29-10-11-30-36-31(20-34(58)48(29,30)6)47(5)14-12-28(56)18-27(47)19-32(36)57)8-7-9-26(2)45(63)79-17-16-50-35(59)13-15-51-43(62)40(61)46(3,4)22-72-78(69,70)75-77(67,68)71-21-33-39(74-76(64,65)66)38(60)44(73-33)55-24-54-37-41(49)52-23-53-42(37)55/h23-34,36,38-40,44,56-58,60-61H,7-22H2,1-6H3,(H,50,59)(H,51,62)(H,67,68)(H,69,70)(H2,49,52,53)(H2,64,65,66)/p-4/t25-,26-,27+,28-,29-,30+,31+,32-,33-,34+,36+,38-,39-,40+,44-,47+,48-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01348 EHMN_ABBREVIATION: C04760
type: Species
is: CHEBI:58677
boundary condition: false
initial amount: NaN
name: (25R)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-oyl-CoA(4-)
initial concentration: 1.0
is: HMDB02178
is: SBO:0000247
constant: false

metaR RE0944E
notes: GENE_ASSOCIATION: (276.1) or (277.1) or (278.1) or (279.1) or (276.1) or (277.1) or (278.1) or (279.1) or (280.1) or (84569.1) SUBSYSTEM: Starch and sucrose metabolism EC Number: 3.2.1.1 Confidence Level: 0 AUTHORS: PMID:385176,PMID:8528071,PMID:890964 NOTES:
modifier: MODEL1310110042#
name: RE0944
is described by: ECO:0000000
reversible: true
fast: false
product: MODEL1310110042#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.2.1.1
type: Reaction
kinetic law: MODEL1310110042#
reactant: MODEL1310110042#
is version of: http://identifiers.org/ec-code/3.2.1.17

metaR r2052
reversible: false
type: Reaction
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
kinetic law: MODEL1310110042#
is: SBO:0000185
fast: false
is described by: ECO:0000000
reactant: MODEL1310110042#
product: MODEL1310110042#
modifier: MODEL1310110042#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.15

http://identifiers.org/biomodels.db/MODEL1310110042#_bdd733d3_0990_41b6_8c59_ee9bf682a4a2
boundary condition: true
constant: false
has only substance units: false
initial concentration: NaN
name: PYCR1
is encoded by: hsa:5831
is: P32322
initial amount: NaN
type: Species
is: SBO:0000252

metaM C02528 c
is: HMDB00518
has only substance units: false
type: Species
is: CHEBI:36234
name: chenodeoxycholate
is: SBO:0000247
constant: false
initial concentration: 1.0
boundary condition: false
notes: FORMULA: C24H39O4 CHARGE: -1 INCHI: InChI=1S/C24H40O4/c1-14(4-7-21(27)28)17-5-6-18-22-19(9-11-24(17,18)3)23(2)10-8-16(25)12-15(23)13-20(22)26/h14-20,22,25-26H,4-13H2,1-3H3,(H,27,28)/p-1/t14-,15+,16-,17-,18+,19+,20-,22+,23+,24-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00958 EHMN_ABBREVIATION: C02528
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110042#_bd8ffa14_a100_406d_8d8f_ae8c2a1e9477
has part: Q9NS82
boundary condition: true
is: SBO:0000297
name: SLC7A10:SLC3A2
initial amount: NaN
type: Species
is encoded by: hsa:6520
has part: P08195
initial concentration: NaN
is encoded by: hsa:56301
constant: false
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110042#_50f6709e_e39c_4c1d_a1df_894db04d901b
is encoded by: hsa:51102
initial amount: NaN
name: MECR
constant: false
type: Species
boundary condition: true
is: Q9BV79
is: SBO:0000252
initial concentration: NaN
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110042#_1849e44d_8889_4601_8a6c_2d7dd2ad0f30
initial amount: NaN
constant: false
is: O14521
type: Species
boundary condition: true
is: SBO:0000252
is encoded by: hsa:6392
has only substance units: false
name: SDHD
initial concentration: NaN

metaM Asn X Ser Thr l
is: CHEBI:28938
initial concentration: 1.0
constant: false
notes: FORMULA: XH CHARGE: 0
type: Species
has only substance units: false
name: protein-linked asparagine residue (N-glycosylation site)
initial amount: NaN
is: SBO:0000247
is: C01342
is: HMDB00051
boundary condition: false

metaM hpyr c
has only substance units: false
initial concentration: 1.0
type: Species
constant: false
notes: FORMULA: C3H3O4 CHARGE: -1 INCHI: InChI=1S/C3H4O4/c4-1-2(5)3(6)7/h4H,1H2,(H,6,7)/p-1 HEPATONET_1.0_ABBREVIATION: HC00163 EHMN_ABBREVIATION: C00168
is: SBO:0000247
is: HMDB01352
is: CHEBI:17180
boundary condition: false
initial amount: NaN
name: 3-hydroxypyruvate

http://identifiers.org/biomodels.db/MODEL1310110042#_3a1fcea0_ee7f_4470_8e84_d23bbe5ec3a3
initial amount: NaN
boundary condition: true
is encoded by: hsa:1503
name: CTPS1
is: SBO:0000252
is: P17812
type: Species
constant: false
has only substance units: false
initial concentration: NaN

metaR GALASE14ly
product: MODEL1310110042#
is version of: http://identifiers.org/ec-code/3.2.1.18
is version of: http://identifiers.org/ec-code/3.1.6.4
type: Reaction
fast: false
kinetic law: MODEL1310110042#
reversible: false
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) or (5476.1) and (2720.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.23 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD
name: beta-galactosidase, lysosomal
modifier: MODEL1310110042#
is: SBO:0000176
reactant: MODEL1310110042#
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/3.4.16.5
is version of: http://identifiers.org/ec-code/3.2.1.23

metaR r2537
fast: false
name: Utilized transport
is: SBO:0000185
type: Reaction
is described by: ECO:0000000
product: MODEL1310110042#
kinetic law: MODEL1310110042#
reactant: MODEL1310110042#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:10049700,PMID:10574970,PMID:11389679,PMID:11557028,PMID:11564694,PMID:12824232,PMID:12930836,PMID:14574404,PMID:16288981,PMID:911815 NOTES:
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110042#_57b1ad5f_6a5a_4dcd_a438_329b817eb2ae
is encoded by: hsa:10327
initial amount: NaN
constant: false
is: SBO:0000252
name: AKR1A1
has only substance units: false
type: Species
boundary condition: true
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110042#_59658c96_fa87_4f7b_94c7_d59df21f1888
has only substance units: false
initial amount: NaN
constant: false
initial concentration: NaN
is: P16066
is: SBO:0000252
boundary condition: true
is encoded by: hsa:4881
type: Species
name: NPR1

metaR EX HC00250 LPAREN e RPAREN
kinetic law: MODEL1310110042#
reactant: MODEL1310110042#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of hydrosulfide
type: Reaction

metaR EX acnacngalgbside hs LPAREN e RPAREN
kinetic law: MODEL1310110042#
reactant: MODEL1310110042#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: disialyl galactosylgloboside (homo sapiens) exchange
type: Reaction

metaM Rtotal3 c
initial concentration: 1.0
initial amount: NaN
constant: false
name: R total 3 position
is: SBO:0000247
boundary condition: false
notes: FORMULA: CO2FULLR3 CHARGE: -1
is: HMDB01448
type: Species
is: CHEBI:16189
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110042#_b9ba45af_d50b_4f3a_aea8_ae7d23474db8
initial concentration: NaN
is encoded by: hsa:766
is: Q86YU0
name: CA7
boundary condition: true
constant: false
is: SBO:0000252
type: Species
initial amount: NaN
has only substance units: false

metaM grdp x
is: SBO:0000247
has only substance units: false
type: Species
is: CHEBI:58057
initial concentration: 1.0
notes: FORMULA: C10H17O7P2 CHARGE: -3 INCHI: InChI=1S/C10H20O7P2/c1-9(2)5-4-6-10(3)7-8-16-19(14,15)17-18(11,12)13/h5,7H,4,6,8H2,1-3H3,(H,14,15)(H2,11,12,13)/p-3/b10-7+ HEPATONET_1.0_ABBREVIATION: HC00288 EHMN_ABBREVIATION: C00341
is: HMDB01285
name: geranyl diphosphate(3-)
boundary condition: false
initial amount: NaN
constant: false

metaM m4mpdol U r
initial concentration: 1.0
is: CHEBI:37633
constant: false
notes: FORMULA: C1485H2440N20O420P20 CHARGE: -20 INCHI: InChI=1S/C71H122N2O42P2/c1-30(2)13-9-14-31(3)15-10-16-32(4)17-11-18-33(5)19-12-20-34(6)21-22-101-116(96,97)115-117(98,99)114-66-45(73-36(8)81)52(88)60(42(28-79)107-66)109-65-44(72-35(7)80)51(87)61(41(27-78)106-65)110-69-59(95)62(50(86)43(108-69)29-100-67-57(93)53(89)46(82)37(23-74)102-67)111-70-64(56(92)49(85)39(25-76)104-70)113-71-63(55(91)48(84)40(26-77)105-71)112-68-58(94)54(90)47(83)38(24-75)103-68/h13,15,17,19,34,37-71,74-79,82-95H,9-12,14,16,18,20-29H2,1-8H3,(H,72,80)(H,73,81)(H,96,97)(H,98,99)/b31-15+,32-17+,33-19+/t34?,37-,38-,39-,40-,41-,42-,43-,44-,45-,46-,47-,48-,49-,50-,51-,52-,53+,54+,55+,56+,57+,58+,59+,60-,61-,62+,63+,64+,65+,66-,67+,68-,69+,70-,71-/m1/s1
boundary condition: false
type: Species
is: SBO:0000247
initial amount: NaN
has only substance units: false
name: (alpha-D-Mannosyl)4-beta-D-mannosyl-diacetylchitobiosyldiphosphodolichol, human uterine homolog

metaR CORE2GTg
reversible: false
modifier: MODEL1310110042#
reactant: MODEL1310110042#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.4.1.102
kinetic law: MODEL1310110042#
notes: GENE_ASSOCIATION: (9245.1) or (2650.1) or (51301.1) SUBSYSTEM: O-glycan synthesis EC Number: 2.4.1.102 Confidence Level: 0 AUTHORS: PMID:10753916,PMID:9915862 NOTES:NCD
product: MODEL1310110042#
fast: false
is described by: ECO:0000000
name: Core 2 acetylglucosaminyltransferase, Golgi apparatus
type: Reaction

metaR r2534
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:10049700,PMID:10574970,PMID:11389679,PMID:11557028,PMID:11564694,PMID:12824232,PMID:12930836,PMID:14574404,PMID:16288981,PMID:911815 NOTES:
fast: false
kinetic law: MODEL1310110042#
type: Reaction
is described by: ECO:0000000
product: MODEL1310110042#
name: Major Facilitator(MFS) TCDB:2.A.1.44.1
reactant: MODEL1310110042#
is: SBO:0000185
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110042#_21edde94_ed60_4018_a82e_48eaf22d6352
type: Species
is: SBO:0000252
boundary condition: true
initial amount: NaN
has only substance units: false
is: Q5SPY7
name: ENTPD2
initial concentration: NaN
is encoded by: hsa:954
constant: false

metaM 34dhoxmand m
is: CHEBI:27637
initial concentration: 1.0
notes: FORMULA: C8H7O5 CHARGE: -1 INCHI: InChI=1S/C8H8O5/c9-5-2-1-4(3-6(5)10)7(11)8(12)13/h1-3,7,9-11H,(H,12,13) HEPATONET_1.0_ABBREVIATION: HC01517 EHMN_ABBREVIATION: C05580
is: SBO:0000247
initial amount: NaN
name: 3,4-Dihydroxymandelate
type: Species
is: HMDB01866
has only substance units: false
boundary condition: false
constant: false

http://identifiers.org/biomodels.db/MODEL1310110042#_61b6f819_725b_40cd_832f_68855f8c8420
name: B3GNT2
is encoded by: hsa:10678
type: Species
has only substance units: false
initial concentration: NaN
is: SBO:0000252
initial amount: NaN
boundary condition: true
constant: false

metaM C02528 e
notes: FORMULA: C24H39O4 CHARGE: -1 INCHI: InChI=1S/C24H40O4/c1-14(4-7-21(27)28)17-5-6-18-22-19(9-11-24(17,18)3)23(2)10-8-16(25)12-15(23)13-20(22)26/h14-20,22,25-26H,4-13H2,1-3H3,(H,27,28)/p-1/t14-,15+,16-,17-,18+,19+,20-,22+,23+,24-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00958 EHMN_ABBREVIATION: C02528
boundary condition: false
is: CHEBI:36234
has only substance units: false
constant: false
is: SBO:0000247
name: chenodeoxycholate
initial amount: NaN
is: HMDB00518
initial concentration: 1.0
type: Species

http://identifiers.org/biomodels.db/MODEL1310110042#_1af3414b_22c7_4408_9d01_87adf51235fd
name: PTDSS2
constant: false
has only substance units: false
is encoded by: hsa:81490
type: Species
is: Q9BVG9
boundary condition: true
is: SBO:0000252
initial concentration: NaN
initial amount: NaN

metaM hdcea c
notes: FORMULA: C16H29O2 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC01981 EHMN_ABBREVIATION: CE0850
has only substance units: false
type: Species
constant: false
is: HMDB03229
is: SBO:0000247
name: Hexadecenoate (n-C16:1)
boundary condition: false
initial concentration: 1.0
initial amount: NaN
is: CHEBI:32372

metaR r0603
product: MODEL1310110042#
notes: GENE_ASSOCIATION: (AW299740.1) or (1737.1) or (J03866.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 1.3.99.12 Confidence Level: 0 AUTHORS: PMID:6401712 NOTES:
type: Reaction
is: SBO:0000176
is described by: ECO:0000000
modifier: MODEL1310110042#
name: (S)-2-methylbutanoyl-CoA:acceptor 2,3-oxidoreductase Valine, leucine and isoleucine degradation EC:1.3.99.12
reactant: MODEL1310110042#
kinetic law: MODEL1310110042#
is version of: http://identifiers.org/ec-code/2.3.1.12
reversible: true
fast: false

metaR r1538
reversible: false
is described by: ECO:0000000
is: SBO:0000185
product: MODEL1310110042#
reactant: MODEL1310110042#
modifier: MODEL1310110042#
is version of: http://identifiers.org/ec-code/1.17.4.1
notes: GENE_ASSOCIATION: (BE966236.1) or (6240.1) or (6241.1) or (50484.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14722772 NOTES:
type: Reaction
kinetic law: MODEL1310110042#
name: Anion Exchanger (AE) TCDB:2.A.31.2.8
fast: false

metaM ksi pre12 g
boundary condition: false
type: Species
name: keratan sulfate I biosynthesis, precursor 12
is: SBO:0000247
initial amount: NaN
initial concentration: 1.0
notes: FORMULA: C135H218N9O106S3X CHARGE: -4
is: C00130
has only substance units: false
constant: false
is: CHEBI:58053
is: HMDB00175

metaM hdcea e
type: Species
is: CHEBI:32372
boundary condition: false
notes: FORMULA: C16H29O2 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC01981 EHMN_ABBREVIATION: CE0850
constant: false
has only substance units: false
is: HMDB03229
is: SBO:0000247
name: Hexadecenoate (n-C16:1)
initial concentration: 1.0
initial amount: NaN

metaM dag hs e
notes: FORMULA: C3H6OFULLRCO2FULLR2CO2 CHARGE: 0
type: Species
is: CHEBI:18035
initial concentration: 1.0
initial amount: NaN
is: SBO:0000247
has only substance units: false
name: diglyceride
boundary condition: false
constant: false

metaR r2535
fast: false
product: MODEL1310110042#
name: Major Facilitator(MFS) TCDB:2.A.1.44.1
type: Reaction
is described by: ECO:0000000
is: SBO:0000185
reactant: MODEL1310110042#
kinetic law: MODEL1310110042#
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:10049700,PMID:10574970,PMID:11389679,PMID:11557028,PMID:11564694,PMID:12824232,PMID:12930836,PMID:14574404,PMID:16288981,PMID:911815 NOTES:

metaR r1156
product: MODEL1310110042#
is: SBO:0000176
is described by: ECO:0000000
fast: false
kinetic law: MODEL1310110042#
name: dUTP:uridine 5-phosphotransferase Pyrimidine metabolism EC:2.7.1.48
type: Reaction
reversible: true
reactant: MODEL1310110042#
notes: GENE_ASSOCIATION: SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.1.48 Confidence Level: 0 AUTHORS: PMID:11306702,PMID:11494055,PMID:64250,PMID:9923963 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110042#_528e3dfb_c18a_4016_8697_ef8cd8d18f12
initial concentration: NaN
is encoded by: hsa:5319
boundary condition: true
initial amount: NaN
type: Species
name: PLA2G1B
constant: false
has only substance units: false
is: P04054
is: SBO:0000252

metaM 3hexdcrn c
initial amount: NaN
type: Species
boundary condition: false
notes: FORMULA: C23H45NO5 CHARGE: 0
name: 3-hydroxyhexadecanoylcarnitine
has only substance units: false
is: HMDB13336
initial concentration: 1.0
constant: false
is: SBO:0000247

metaM dmnoncrn x
name: 4,8-dimethylnonanoyl carnitine
initial concentration: 1.0
notes: FORMULA: C18H37NO4 CHARGE: 0
is: HMDB06202
is: SBO:0000247
type: Species
constant: false
has only substance units: false
initial amount: NaN
boundary condition: false

metaR C162OHe
kinetic law: MODEL1310110042#
product: MODEL1310110042#
reactant: MODEL1310110042#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: excretion of C16:2OH
type: Reaction

metaM gpi sig r
type: Species
is: HMDB00224
has only substance units: false
name: glycophosphatidylinositol (GPI) signal sequence (C-terminal peptide)
boundary condition: false
is: SBO:0000247
initial concentration: 1.0
constant: false
is: CHEBI:58190
notes: FORMULA: Y CHARGE: 0
initial amount: NaN

metaR EX 10fthf7glu LPAREN e RPAREN
kinetic law: MODEL1310110042#
reactant: MODEL1310110042#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 10-formyltetrahydrofolate-[Glu](7) exchange
type: Reaction

metaM prostge1 c
initial amount: NaN
type: Species
is: HMDB01442
name: prostaglandin E1(1-)
is: SBO:0000247
has only substance units: false
is: CHEBI:57397
initial concentration: 1.0
boundary condition: false
notes: FORMULA: C20H33O5 CHARGE: -1 INCHI: InChI=1S/C20H34O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h12-13,15-17,19,21,23H,2-11,14H2,1H3,(H,24,25)/p-1/b13-12+/t15-,16+,17+,19+/m0/s1 EHMN_ABBREVIATION: C04741
constant: false

metaR FAOXC226C225x
kinetic law: MODEL1310110042#
product: MODEL1310110042#
reactant: MODEL1310110042#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C22:6-->C22:5)x
type: Reaction

metaR DGSNt
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10899995 NOTES:
product: MODEL1310110042#
fast: false
name: deoyguanosine transport via diffusion
type: Reaction
is described by: ECO:0000000
kinetic law: MODEL1310110042#
reactant: MODEL1310110042#
reversible: true

metaM 3htdcoa m
is: HMDB02288
initial amount: NaN
has only substance units: false
constant: false
boundary condition: false
type: Species
name: (S)-3-Hydroxytetradecanoyl-CoA
initial concentration: 1.0
is: SBO:0000247
notes: FORMULA: C35H58N7O18P3S CHARGE: -4

metaR MI1345PP
reversible: false
is version of: http://identifiers.org/ec-code/3.1.3.56
fast: false
is: SBO:0000176
modifier: MODEL1310110042#
type: Reaction
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (3635.1) or (8867.2) or (3636.1) or (27124.2) or (8867.1) or (27124.1) or (3633.1) or (56623.1) or (3632.1) SUBSYSTEM: Inositol phosphate metabolism EC Number: 3.1.3.56 Confidence Level: 4 AUTHORS: PMID:10593988,PMID:10764818,PMID:15261714,PMID:2906139,PMID:7721860,PMID:8006039,PMID:8013665,PMID:8530088,PMID:8769125,PMID:9428629,PMID:9824312 NOTES:NCD
is version of: http://identifiers.org/ec-code/3.1.3.36
kinetic law: MODEL1310110042#
is version of: http://identifiers.org/ec-code/3.1.3.86
reactant: MODEL1310110042#
name: inositol-1,3,4,5-trisphosphate 5-phosphatase
product: MODEL1310110042#

metaR ME2
reversible: false
is: SBO:0000176
fast: false
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (4199.1) SUBSYSTEM: Pyruvate metabolism EC Number: 1.1.1.40 Confidence Level: 0 AUTHORS: PMID:1993674 NOTES:
is version of: http://identifiers.org/ec-code/1.1.1.40
type: Reaction
reactant: MODEL1310110042#
kinetic law: MODEL1310110042#
modifier: MODEL1310110042#
product: MODEL1310110042#
name: malic enzyme (NADP)

metaR r2532
kinetic law: MODEL1310110042#
fast: false
name: Major Facilitator(MFS) TCDB:2.A.1.44.1
product: MODEL1310110042#
type: Reaction
is described by: ECO:0000000
reactant: MODEL1310110042#
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:10049700,PMID:10574970,PMID:11389679,PMID:11557028,PMID:11564694,PMID:12824232,PMID:12930836,PMID:14574404,PMID:16288981,PMID:911815 NOTES:
is: SBO:0000185

metaR LNLNCGCRNt
kinetic law: MODEL1310110042#
reversible: false
reactant: MODEL1310110042#
product: MODEL1310110042#
is described by: ECO:0000269
name: transport into the mitochondria (carnitine)
is: SBO:0000185
fast: false
notes: GENE_ASSOCIATION: (788.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: NOTES:NJ
type: Reaction
modifier: MODEL1310110042#

metaM adp r
constant: false
name: ADP(3-)
type: Species
boundary condition: false
is: HMDB01341
notes: FORMULA: C10H12N5O10P2 CHARGE: -3 INCHI: InChI=1S/C10H15N5O10P2/c11-8-5-9(13-2-12-8)15(3-14-5)10-7(17)6(16)4(24-10)1-23-27(21,22)25-26(18,19)20/h2-4,6-7,10,16-17H,1H2,(H,21,22)(H2,11,12,13)(H2,18,19,20)/p-3/t4-,6-,7-,10-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00018 EHMN_ABBREVIATION: C00008
is: SBO:0000247
has only substance units: false
initial concentration: 1.0
initial amount: NaN
is: CHEBI:456216

metaR GGH 10FTHF5GLUe
fast: false
is version of: http://identifiers.org/ec-code/3.4.19.9
type: Reaction
kinetic law: MODEL1310110042#
modifier: MODEL1310110042#
product: MODEL1310110042#
notes: GENE_ASSOCIATION: (8836.1) SUBSYSTEM: Folate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:11375437,PMID:2867095,PMID:9614206 NOTES:REMOVES EITHER ONE OR TWO GLUTAMYL RESIDUES WITH A REACTION (WILL ONLY REPRESENT 1) - last step from 5-glutamyl to monoglutamyl is in one step IT
name: Gamma-glutamyl hydrolase (10FTHF5GLU), extracellular
reactant: MODEL1310110042#
is described by: ECO:0000000
is: SBO:0000176
reversible: false

metaM gluside hs c
notes: FORMULA: C24H46NO7FULLRCO CHARGE: 0 EHMN_ABBREVIATION: C01190
name: D-glucosyl-N-acylsphingosine
is: CHEBI:18368
constant: false
type: Species
initial amount: NaN
boundary condition: false
has only substance units: false
is: SBO:0000247
initial concentration: 1.0

metaR r0754
reactant: MODEL1310110042#
type: Reaction
modifier: MODEL1310110042#
notes: GENE_ASSOCIATION: (2194.1) SUBSYSTEM: Unassigned EC Number: 1.2.1.5 Confidence Level: 0 AUTHORS: PMID:17379813,PMID:18621017 NOTES:
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.3.1.85
kinetic law: MODEL1310110042#
is described by: ECO:0000000
reversible: true
product: MODEL1310110042#
fast: false
name: 3-Methoxy-4-hydroxyphenylacetaldehyde:NAD+ oxidoreductase Tyrosine metabolism EC:1.2.1.5

metaM eicostetcoa c
is: SBO:0000247
name: eicosatetranoyl coenzyme A
constant: false
initial concentration: 1.0
notes: FORMULA: C41H62N7O17P3S CHARGE: -4 INCHI: InChI=1/C41H66N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-32(50)69-25-24-43-31(49)22-23-44-39(53)36(52)41(2,3)27-62-68(59,60)65-67(57,58)61-26-30-35(64-66(54,55)56)34(51)40(63-30)48-29-47-33-37(42)45-28-46-38(33)48/h5-6,8-9,11-12,14-15,28-30,34-36,40,51-52H,4,7,10,13,16-27H2,1-3H3,(H,43,49)(H,44,53)(H,57,58)(H,59,60)(H2,42,45,46)(H2,54,55,56)/b6-5-,9-8-,12-11-,15-14-/t30-,34-,35-,36?,40-/m1/s1
type: Species
initial amount: NaN
boundary condition: false
has only substance units: false
is: C16164

metaM CE4872 c
initial concentration: 1.0
boundary condition: false
initial amount: NaN
constant: false
name: 3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-27-al
has only substance units: false
notes: FORMULA: C27H46O4 CHARGE: 0 INCHI: InChI=1/C27H46O4/c1-16(15-28)6-5-7-17(2)20-8-9-21-25-22(14-24(31)27(20,21)4)26(3)11-10-19(29)12-18(26)13-23(25)30/h15-25,29-31H,5-14H2,1-4H3/t16u,17-,18-,19+,20-,21-,22-,23+,24-,25-,26?,27-/m1/s1 EHMN_ABBREVIATION: CE4872
is: CHEBI:15748
type: Species
is: HMDB00127
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110042#_8c8e4648_484b_4410_b7ee_c7fcfdd134e9
type: Species
is: P55084
has only substance units: false
initial concentration: NaN
initial amount: NaN
constant: false
is: SBO:0000252
is encoded by: hsa:3032
boundary condition: true
name: HADHB

metaM pro L e
is: CHEBI:17203
type: Species
initial amount: NaN
notes: FORMULA: C5H9NO2 CHARGE: 0 INCHI: InChI=1S/C5H9NO2/c7-5(8)4-2-1-3-6-4/h4,6H,1-3H2,(H,7,8)/t4-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00145
is: HMDB00162
is: SBO:0000247
has only substance units: false
boundary condition: false
initial concentration: 1.0
name: L-proline
constant: false

metaM strdnc e
notes: FORMULA: C18H27O2 CHARGE: -1 INCHI: InChI=1/C18H28O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20/h3-4,6-7,9-10,12-13H,2,5,8,11,14-17H2,1H3,(H,19,20)/b4-3-,7-6-,10-9-,13-12- HEPATONET_1.0_ABBREVIATION: HC00793
initial amount: NaN
name: stearidonic acid C18:4, n-3
boundary condition: false
is: C16300
has only substance units: false
initial concentration: 1.0
type: Species
is: SBO:0000247
is: HMDB06547
constant: false
is: http://identifiers.org/pubchem.compound/47205608

http://identifiers.org/biomodels.db/MODEL1310110042#_420f747f_5c49_428d_8183_18c673a78787
boundary condition: true
has only substance units: false
initial concentration: NaN
constant: false
name: DTYMK
is: SBO:0000252
type: Species
is encoded by: hsa:1841
initial amount: NaN
is: P23919

metaR ITCOAL1m
is described by: ECO:0000304
fast: false
modifier: MODEL1310110042#
product: MODEL1310110042#
reversible: true
type: Reaction
kinetic law: MODEL1310110042#
reactant: MODEL1310110042#
is version of: http://identifiers.org/ec-code/6.2.1.4
name: Itaconate--CoA ligase (GDP-forming), mitochondrial
notes: GENE_ASSOCIATION: (8802.1 and 8801.1) SUBSYSTEM: C5-branched dibasic acid metabolism EC Number: 6.2.1.4 Confidence Level: 2 AUTHORS: PMID:13783048 NOTES:NCD
is: SBO:0000176

metaR OCTDECCPT1
kinetic law: MODEL1310110042#
product: MODEL1310110042#
reactant: MODEL1310110042#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: transport of Octadecenoyl-CoA into mitochondrial matrix
type: Reaction

metaM 3hexdcrn e
initial amount: NaN
type: Species
boundary condition: false
notes: FORMULA: C23H45NO5 CHARGE: 0
is: HMDB13336
name: 3-hydroxyhexadecanoylcarnitine
constant: false
has only substance units: false
is: SBO:0000247
initial concentration: 1.0

metaR C162OHc
kinetic law: MODEL1310110042#
product: MODEL1310110042#
reactant: MODEL1310110042#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: production of 3-hydroxy hexadecadienoyl carnitine
type: Reaction

metaR r0755
reversible: true
type: Reaction
name: 3-Methoxy-4-hydroxyphenylacetaldehyde:NADP+ oxidoreductase Tyrosine metabolism EC:1.2.1.5
kinetic law: MODEL1310110042#
is: SBO:0000176
modifier: MODEL1310110042#
fast: false
reactant: MODEL1310110042#
product: MODEL1310110042#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (27034.1) or (28976.1) or (37.1) SUBSYSTEM: Unassigned EC Number: 1.2.1.5 Confidence Level: 0 AUTHORS: PMID:1898068 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110042#_f5fc50ef_c813_493f_8672_99a4784c3ee9
name: PRDX2
boundary condition: true
is: SBO:0000252
initial amount: NaN
initial concentration: NaN
type: Species
constant: false
has only substance units: false
is encoded by: hsa:7001

metaM ach n
initial concentration: 1.0
name: acetylcholine
initial amount: NaN
is: HMDB00895
constant: false
has only substance units: false
boundary condition: false
notes: FORMULA: C7H16NO2 CHARGE: 1 INCHI: InChI=1S/C7H16NO2/c1-7(9)10-6-5-8(2,3)4/h5-6H2,1-4H3/q+1 HEPATONET_1.0_ABBREVIATION: HC00877 EHMN_ABBREVIATION: C01996
is: SBO:0000247
type: Species
is: CHEBI:15355

metaM dag hs r
boundary condition: false
is: CHEBI:18035
constant: false
initial amount: NaN
type: Species
has only substance units: false
is: SBO:0000247
notes: FORMULA: C3H6OFULLRCO2FULLR2CO2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC02055
initial concentration: 1.0
name: diglyceride

metaM eicostetcoa m
initial amount: NaN
initial concentration: 1.0
notes: FORMULA: C41H62N7O17P3S CHARGE: -4 INCHI: InChI=1/C41H66N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-32(50)69-25-24-43-31(49)22-23-44-39(53)36(52)41(2,3)27-62-68(59,60)65-67(57,58)61-26-30-35(64-66(54,55)56)34(51)40(63-30)48-29-47-33-37(42)45-28-46-38(33)48/h5-6,8-9,11-12,14-15,28-30,34-36,40,51-52H,4,7,10,13,16-27H2,1-3H3,(H,43,49)(H,44,53)(H,57,58)(H,59,60)(H2,42,45,46)(H2,54,55,56)/b6-5-,9-8-,12-11-,15-14-/t30-,34-,35-,36?,40-/m1/s1
boundary condition: false
is: SBO:0000247
is: C16164
name: eicosatetranoyl coenzyme A
has only substance units: false
constant: false
type: Species

metaR r0021
product: MODEL1310110042#
modifier: MODEL1310110042#
is version of: http://identifiers.org/ec-code/3.6.1.5
is: SBO:0000176
kinetic law: MODEL1310110042#
reactant: MODEL1310110042#
name: glutathione:NAD+ oxidoreductase Glutamate metabolism EC:1.8.1.7
fast: false
is described by: ECO:0000000
reversible: true
notes: GENE_ASSOCIATION: (AV717590.1) or (953.1) or (954.1) or (956.1) or (377841.1) SUBSYSTEM: Glutathione metabolism EC Number: 1.8.1.7 Confidence Level: 0 AUTHORS: PMID:10781871,PMID:12821209,PMID:237878,PMID:31912,PMID:4380255,PMID:8981046,PMID:9621574 NOTES:IT - fixed proton
type: Reaction

metaR r2121
product: MODEL1310110042#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
reactant: MODEL1310110042#
modifier: MODEL1310110042#
is described by: ECO:0000000
type: Reaction
kinetic law: MODEL1310110042#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
reversible: true
is: SBO:0000185
fast: false

metaM 34dhpac c
type: Species
boundary condition: false
initial concentration: 1.0
is: HMDB03791
name: 3,4-Dihydroxyphenylacetaldehyde
initial amount: NaN
has only substance units: false
is: SBO:0000247
is: CHEBI:27978
notes: FORMULA: C8H8O3 CHARGE: 0 INCHI: InChI=1S/C8H8O3/c9-4-3-6-1-2-7(10)8(11)5-6/h1-2,4-5,10-11H,3H2 EHMN_ABBREVIATION: C04043
constant: false

metaM 5adtststerone e
has only substance units: false
type: Species
is: HMDB02961
is: SBO:0000247
initial concentration: 1.0
boundary condition: false
initial amount: NaN
notes: FORMULA: C19H30O2 CHARGE: 0 INCHI: InChI=1S/C19H30O2/c1-18-9-7-13(20)11-12(18)3-4-14-15-5-6-17(21)19(15,2)10-8-16(14)18/h12,14-17,21H,3-11H2,1-2H3/t12-,14-,15-,16-,17-,18-,19-/m0/s1 EHMN_ABBREVIATION: C03917
constant: false
name: 17beta-hydroxy-5alpha-androstan-3-one
is: CHEBI:16330

metaM prpncoa m
notes: FORMULA: C24H34N7O17P3S CHARGE: -4 INCHI: InChI=1S/C24H38N7O17P3S/c1-4-15(33)52-8-7-26-14(32)5-6-27-22(36)19(35)24(2,3)10-45-51(42,43)48-50(40,41)44-9-13-18(47-49(37,38)39)17(34)23(46-13)31-12-30-16-20(25)28-11-29-21(16)31/h4,11-13,17-19,23,34-35H,1,5-10H2,2-3H3,(H,26,32)(H,27,36)(H,40,41)(H,42,43)(H2,25,28,29)(H2,37,38,39)/p-4/t13-,17-,18-,19+,23-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00579 EHMN_ABBREVIATION: C00894
constant: false
has only substance units: false
name: acryloyl-CoA(4-)
initial concentration: 1.0
is: HMDB02307
initial amount: NaN
boundary condition: false
is: CHEBI:57367
is: SBO:0000247
type: Species

http://identifiers.org/biomodels.db/MODEL1310110042#_e55c0fc9_7acb_4b3a_ab28_5607b1af8eed
initial amount: NaN
has only substance units: false
is encoded by: hsa:4830
initial concentration: NaN
boundary condition: true
type: Species
is: SBO:0000252
constant: false
name: NME1

metaR SIAASE4ly
kinetic law: MODEL1310110042#
is version of: http://identifiers.org/ec-code/3.2.1.23
is version of: http://identifiers.org/ec-code/3.4.16.5
is version of: http://identifiers.org/ec-code/3.1.6.4
product: MODEL1310110042#
name: sialidase, lysosomal
type: Reaction
fast: false
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.18 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD
reactant: MODEL1310110042#
reversible: false
is version of: http://identifiers.org/ec-code/3.2.1.18
is described by: ECO:0000000
is: SBO:0000176
modifier: MODEL1310110042#

metaR r2347
reversible: true
reactant: MODEL1310110042#
is: SBO:0000185
name: Organic anion transporter 5 Utilized transport
kinetic law: MODEL1310110042#
is described by: ECO:0000000
fast: false
product: MODEL1310110042#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
type: Reaction

metaM CE4872 m
boundary condition: false
constant: false
initial concentration: 1.0
name: 3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-27-al
is: SBO:0000247
notes: FORMULA: C27H46O4 CHARGE: 0 INCHI: InChI=1/C27H46O4/c1-16(15-28)6-5-7-17(2)20-8-9-21-25-22(14-24(31)27(20,21)4)26(3)11-10-19(29)12-18(26)13-23(25)30/h15-25,29-31H,5-14H2,1-4H3/t16u,17-,18-,19+,20-,21-,22-,23+,24-,25-,26?,27-/m1/s1 EHMN_ABBREVIATION: CE4872
is: HMDB00127
type: Species
has only substance units: false
is: CHEBI:15748
initial amount: NaN

metaM dhf c
has only substance units: false
initial concentration: 1.0
is: SBO:0000247
is: C00415
type: Species
initial amount: NaN
is: CHEBI:57451
constant: false
notes: FORMULA: C19H19N7O6 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00340 EHMN_ABBREVIATION: C00415
name: 7,8-Dihydrofolate
is: HMDB01056
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110042#_cef00a64_a3d9_4159_b071_8f07a94acd5d
initial amount: NaN
is: SBO:0000252
initial concentration: NaN
is: P00813
name: ADA
type: Species
is encoded by: hsa:100
has only substance units: false
boundary condition: true
constant: false

metaR r1971
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reactant: MODEL1310110042#
is described by: ECO:0000000
reversible: false
modifier: MODEL1310110042#
type: Reaction
name: Y+LAT2 Utilized transport
kinetic law: MODEL1310110042#
is: SBO:0000185
fast: false
product: MODEL1310110042#

metaM cs e deg1 l
initial concentration: 1.0
is: SBO:0000247
name: chondroitin sulfate E (GalNAc4,6diS-GlcA), degradation product 1
is: CHEBI:57737
is: HMDB00868
initial amount: NaN
type: Species
notes: FORMULA: C45H65N2O52S5 CHARGE: -7
has only substance units: false
boundary condition: false
constant: false

http://identifiers.org/biomodels.db/MODEL1310110042#_b2b8e331_1808_4c6d_a9d0_4c87aea1e0e6
type: Species
is: O00443
constant: false
name: PIK3C2A
is encoded by: hsa:5286
initial concentration: NaN
is: SBO:0000252
initial amount: NaN
boundary condition: true
has only substance units: false

metaM ksii core4 deg3 l
has only substance units: false
is: CHEBI:12936
initial amount: NaN
type: Species
constant: false
is: HMDB00143
initial concentration: 1.0
is: SBO:0000247
boundary condition: false
name: keratan sulfate II (core 4-linked), degradation product 3
notes: FORMULA: C66H107N6O51S2X CHARGE: -2

metaM dhf e
has only substance units: false
is: HMDB01056
constant: false
notes: FORMULA: C19H19N7O6 CHARGE: -2 INCHI: InChI=1S/C19H21N7O6/c20-19-25-15-14(17(30)26-19)23-11(8-22-15)7-21-10-3-1-9(2-4-10)16(29)24-12(18(31)32)5-6-13(27)28/h1-4,12,21H,5-8H2,(H,24,29)(H,27,28)(H,31,32)(H4,20,22,25,26,30)/p-2/t12-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00340 EHMN_ABBREVIATION: C00415
initial amount: NaN
boundary condition: false
name: dihydrofolate(2-)
is: SBO:0000247
initial concentration: 1.0
type: Species
is: CHEBI:57451

metaR RE3245C
reversible: true
product: MODEL1310110042#
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:0 NOTES:IT - fixed proton
is described by: ECO:0000000
fast: false
reactant: MODEL1310110042#
name: RE3245
type: Reaction
is: SBO:0000176
kinetic law: MODEL1310110042#

metaR r2120
reactant: MODEL1310110042#
reversible: true
kinetic law: MODEL1310110042#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
is: SBO:0000185
fast: false
modifier: MODEL1310110042#
is described by: ECO:0000000
type: Reaction
product: MODEL1310110042#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:

metaR r0022
notes: GENE_ASSOCIATION: (AA532636.1) or (2936.1) SUBSYSTEM: Glutathione metabolism EC Number: 1.8.1.7 Confidence Level: 0 AUTHORS: PMID:10781871,PMID:12821209,PMID:237878,PMID:31912,PMID:4380255,PMID:8981046,PMID:9621574 NOTES:
name: glutathione:NAD+ oxidoreductase Glutamate metabolism EC:1.8.1.7
product: MODEL1310110042#
is described by: ECO:0000000
kinetic law: MODEL1310110042#
reversible: true
reactant: MODEL1310110042#
is version of: http://identifiers.org/ec-code/1.8.1.7
type: Reaction
modifier: MODEL1310110042#
fast: false
is: SBO:0000176

metaM udpglcur r
is: CHEBI:58052
is: SBO:0000247
is: HMDB00935
has only substance units: false
name: UDP-D-glucuronate
initial concentration: 1.0
is: C00167
type: Species
constant: false
notes: FORMULA: C15H19N2O18P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00162 EHMN_ABBREVIATION: C00167
initial amount: NaN
boundary condition: false

metaR GCHOLAte
is described by: ECO:0000000
name: bile acid intracellular transport
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:unknown mechanism, however bile acids need to be secreted out of the cell NJ
kinetic law: MODEL1310110042#
reversible: true
is: SBO:0000185
type: Reaction
fast: false
reactant: MODEL1310110042#
product: MODEL1310110042#

metaM pro L c
is: HMDB00162
initial amount: NaN
constant: false
boundary condition: false
initial concentration: 1.0
is: SBO:0000247
is: CHEBI:17203
type: Species
notes: FORMULA: C5H9NO2 CHARGE: 0 INCHI: InChI=1S/C5H9NO2/c7-5(8)4-2-1-3-6-4/h4,6H,1-3H2,(H,7,8)/t4-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00145
has only substance units: false
name: L-proline

metaR ATP2ter
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: NOTES:NCD
reversible: true
fast: false
name: AMP/ATP transporter, endoplasmic reticulum
type: Reaction
is described by: ECO:0000000
product: MODEL1310110042#
kinetic law: MODEL1310110042#
is: SBO:0000185
reactant: MODEL1310110042#

metaR r2346
name: Organic anion transporter 5 Utilized transport
kinetic law: MODEL1310110042#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
type: Reaction
reversible: true
fast: false
product: MODEL1310110042#
is described by: ECO:0000000
reactant: MODEL1310110042#
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110042#_bc498e2d_f9fa_4cd6_b42a_6ac564c0c761
is: SBO:0000252
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:160728
type: Species
is: Q8N695
constant: false
name: SLC5A8
boundary condition: true
has only substance units: false

metaR ARTCOAL3
kinetic law: MODEL1310110042#
is described by: ECO:0000000
fast: false
reactant: MODEL1310110042#
name: R group coenzyme a ligase
notes: GENE_ASSOCIATION: SUBSYSTEM: R group synthesis EC Number: Confidence Level: 0 AUTHORS: NOTES:HR fatty acid metabolism - R groups = acyl groups, Rtotal, Rtotal2, Rtotal3 correspond to three possible acyl groups added to glycerol Carbon stoichiometry normalized wrt C16 R1 - C16 groups R2 - essential FA + associated derivatives R3 - non-essential, dietary FA (C18) R4 - monounsaturated FA R5 -other (C26, C24) NJ
is: SBO:0000176
type: Reaction
reversible: false
product: MODEL1310110042#

metaR r1429
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 0 AUTHORS: PMID:17045662 NOTES:
is described by: ECO:0000000
fast: false
is: SBO:0000185
product: MODEL1310110042#
reactant: MODEL1310110042#
reversible: true
type: Reaction
kinetic law: MODEL1310110042#
name: Free diffusion

http://identifiers.org/biomodels.db/MODEL1310110042#_2c62c082_b934_40cb_9cd0_c8b160857b6e
boundary condition: true
is encoded by: hsa:107
constant: false
type: Species
is: Q08828
name: ADCY1
initial amount: NaN
has only substance units: false
initial concentration: NaN
is: SBO:0000252

metaR FAOXC240200x
modifier: MODEL1310110042#
is version of: http://identifiers.org/ec-code/1.3.3.6
kinetic law: MODEL1310110042#
is version of: http://identifiers.org/ec-code/4.2.1.107
is version of: http://identifiers.org/ec-code/1.1.1.35
product: MODEL1310110042#
is version of: http://identifiers.org/ec-code/2.3.1.16
type: Reaction
name: Beta oxidation of long chain fatty acid
notes: GENE_ASSOCIATION: (51.1 and 3295.1 and 30.1) or (30.1 and 51.2 and 1962.1) or (51.1 and 30.1 and 1962.1) or (3295.1 and 30.1 and 51.2) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.74 Confidence Level: 4 AUTHORS: NOTES:peroxisomal (very long chain FA) - in peroxisome, no fad, 1ste set of beta-ox is by acyl-coa oxidase (passes electrons directly to o2 -> h2o2) c24:0 -> c20:0 4 step FAO lumped for 2 rounds also includes EC 1.1.1.35, 1.1.1.211, 1.3.3.6, 4.2.1.17, 4.2.1.74 NJ
is described by: ECO:0000000
reactant: MODEL1310110042#
fast: false
is: SBO:0000176
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110042#_d0ed28d8_a2ff_421f_a845_b4a6537cc494
has only substance units: false
constant: false
type: Species
initial amount: NaN
initial concentration: NaN
boundary condition: true
is encoded by: hsa:514
is encoded by: hsa:513
is: SBO:0000297
name: ATP5A1:ATP5B:ATP5C1:ATP5D:ATP5E

metaM 3dphb m
constant: false
name: 3-Decaprenyl-4-hydroxybenzoate
is: SBO:0000247
type: Species
initial amount: NaN
notes: FORMULA: C57H85O3 CHARGE: -1 INCHI: InChI=1/C57H86O3/c1-44(2)21-12-22-45(3)23-13-24-46(4)25-14-26-47(5)27-15-28-48(6)29-16-30-49(7)31-17-32-50(8)33-18-34-51(9)35-19-36-52(10)37-20-38-53(11)39-40-54-43-55(57(59)60)41-42-56(54)58/h21,23,25,27,29,31,33,35,37,39,41-43,58H,12-20,22,24,26,28,30,32,34,36,38,40H2,1-11H3,(H,59,60)/b45-23+,46-25+,47-27+,48-29+,49-31+,50-33+,51-35+,52-37+,53-39+
boundary condition: false
has only substance units: false
is: HMDB06251
initial concentration: 1.0

metaR r0758
is version of: http://identifiers.org/ec-code/3.5.4.16
type: Reaction
is: SBO:0000176
fast: false
notes: GENE_ASSOCIATION: (2643.1) SUBSYSTEM: Tryptophan metabolism EC Number: 1.2.1.3 Confidence Level: 0 AUTHORS: PMID:8155713,PMID:8605195 NOTES:
reversible: true
reactant: MODEL1310110042#
kinetic law: MODEL1310110042#
is described by: ECO:0000000
name: 5-Hydroxyindoleacetaldehyde:NAD+ oxidoreductase Tryptophan metabolism EC:1.2.1.3
product: MODEL1310110042#
modifier: MODEL1310110042#

metaR r2123
product: MODEL1310110042#
reactant: MODEL1310110042#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
is described by: ECO:0000000
type: Reaction
modifier: MODEL1310110042#
kinetic law: MODEL1310110042#
is: SBO:0000185
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
fast: false
reversible: true

metaM btamp m
initial amount: NaN
is: SBO:0000247
name: Biotinyl-5'-AMP
notes: FORMULA: C20H27N7O9PS CHARGE: -1 INCHI: InChI=1S/C20H28N7O9PS/c21-17-14-18(23-7-22-17)27(8-24-14)19-16(30)15(29)10(35-19)5-34-37(32,33)36-12(28)4-2-1-3-11-13-9(6-38-11)25-20(31)26-13/h7-11,13,15-16,19,29-30H,1-6H2,(H,32,33)(H2,21,22,23)(H2,25,26,31)/t9-,10+,11-,13-,15+,16+,19+/m0/s1 EHMN_ABBREVIATION: C05921
type: Species
constant: false
is: HMDB04220
initial concentration: 1.0
is: CHEBI:3110
has only substance units: false
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110042#_072a755e_3823_4806_bf1e_03d4069a5a3d
boundary condition: true
is encoded by: hsa:54344
initial concentration: NaN
name: DPM3
is: SBO:0000252
has only substance units: false
type: Species
initial amount: NaN
is: Q86TM7
constant: false

metaM cspg e l
initial concentration: 1.0
name: chondroitin sulfate E (GalNAc4,6diS-GlcA) proteoglycan
is: HMDB02183
has only substance units: false
type: Species
notes: FORMULA: C45H63N2O54S6X CHARGE: -8
constant: false
boundary condition: false
initial amount: NaN
is: CHEBI:36005
is: SBO:0000247

metaM Rtotal3coa c
type: Species
is: SBO:0000247
initial amount: NaN
initial concentration: 1.0
boundary condition: false
has only substance units: false
notes: FORMULA: CO2FULLR3C21H31N7O15P3S CHARGE: -4
is: CHEBI:16189
constant: false
is: HMDB01448
name: R total 3 Coenzyme A

http://identifiers.org/biomodels.db/MODEL1310110042#_4cf9902f_2fcf_449f_a451_c9c430559b7c
is encoded by: hsa:10317
has only substance units: false
initial concentration: NaN
type: Species
is: SBO:0000252
name: B3GALT5
constant: false
boundary condition: true
initial amount: NaN

metaM CE4790 m
initial amount: NaN
has only substance units: false
initial concentration: 1.0
name: (3S)-3-hydroxy-cis-8-tetradecenoyl-CoA
is: CHEBI:57923
type: Species
notes: FORMULA: C35H56N7O18P3S CHARGE: -4 INCHI: InChI=1/C35H60N7O18P3S/c1-4-5-6-7-8-9-10-11-12-13-23(43)18-26(45)64-17-16-37-25(44)14-15-38-33(48)30(47)35(2,3)20-57-63(54,55)60-62(52,53)56-19-24-29(59-61(49,50)51)28(46)34(58-24)42-22-41-27-31(36)39-21-40-32(27)42/h8-9,21-24,28-30,34,43,46-47H,4-7,10-20H2,1-3H3,(H,37,44)(H,38,48)(H,52,53)(H,54,55)(H2,36,39,40)(H2,49,50,51)/p-4/b9-8-/t23-,24-,28+,29+,30u,34-/m0/s1 EHMN_ABBREVIATION: CE4790
is: SBO:0000247
constant: false
boundary condition: false

metaM 5adtststerone c
name: 17beta-hydroxy-5alpha-androstan-3-one
is: SBO:0000247
notes: FORMULA: C19H30O2 CHARGE: 0 INCHI: InChI=1S/C19H30O2/c1-18-9-7-13(20)11-12(18)3-4-14-15-5-6-17(21)19(15,2)10-8-16(14)18/h12,14-17,21H,3-11H2,1-2H3/t12-,14-,15-,16-,17-,18-,19-/m0/s1 EHMN_ABBREVIATION: C03917
constant: false
initial concentration: 1.0
has only substance units: false
is: CHEBI:16330
is: HMDB02961
initial amount: NaN
boundary condition: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110042#_732ce8e5_5678_4fc5_8d44_d55cf0f3d980
initial concentration: NaN
is: SBO:0000252
initial amount: NaN
type: Species
name: INPP5J
constant: false
has only substance units: false
is: Q15735
is encoded by: hsa:27124
boundary condition: true

metaR r1428
type: Reaction
is: SBO:0000185
name: Free diffusion
product: MODEL1310110042#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 0 AUTHORS: PMID:17045662 NOTES:
reactant: MODEL1310110042#
is described by: ECO:0000000
kinetic law: MODEL1310110042#
fast: false
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110042#_ba2df856_2e7a_4c52_9c8a_b5b7d7f4341b
is encoded by: hsa:1609
name: DGKQ
is: P52824
initial concentration: NaN
boundary condition: true
initial amount: NaN
is: SBO:0000252
constant: false
has only substance units: false
type: Species

metaR ADNt4
is described by: ECO:0000269
is: SBO:0000185
product: MODEL1310110042#
type: Reaction
modifier: MODEL1310110042#
name: adenosine transport (Na/Adn cotransport)
notes: GENE_ASSOCIATION: (9154.2) or (9154.1) or (64078.1) or (9153.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12856181 NOTES:MM
kinetic law: MODEL1310110042#
reversible: false
reactant: MODEL1310110042#
fast: false

http://identifiers.org/biomodels.db/MODEL1310110042#_93297ec7_f6eb_4ab0_9e1f_2e1e00c3d259
type: Species
has only substance units: false
name: ATP5F1
initial concentration: NaN
is: SBO:0000252
constant: false
is encoded by: hsa:515
is: P24539
initial amount: NaN
boundary condition: true

metaR APOCFm
fast: false
kinetic law: MODEL1310110042#
is: SBO:0000176
reversible: false
name: Apocarboxylase formation, mitochondrial
type: Reaction
reactant: MODEL1310110042#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Biotin metabolism EC Number: Confidence Level: 2 AUTHORS: NOTES:IT faked reaction to balance reaction in human biotin metabolism
product: MODEL1310110042#

http://identifiers.org/biomodels.db/MODEL1310110042#_1477d582_e74d_4f6d_a8c7_71a67ef898f1
has only substance units: false
initial amount: NaN
initial concentration: NaN
name: _AI972237_1_c
constant: false
is encoded by: hsa:AI972237
boundary condition: true
type: Species
is: SBO:0000252

metaR r2122
reversible: true
kinetic law: MODEL1310110042#
is: SBO:0000185
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
is described by: ECO:0000000
fast: false
type: Reaction
modifier: MODEL1310110042#
product: MODEL1310110042#
reactant: MODEL1310110042#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:

metaR EX dopa LPAREN e RPAREN
kinetic law: MODEL1310110042#
reactant: MODEL1310110042#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Dopamine exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110042#_53e82cf2_c4d5_4eb7_9ec9_e102f2f73713
type: Species
initial amount: NaN
is: SBO:0000252
is: Q96RQ3
constant: false
is encoded by: hsa:56922
name: MCCC1
boundary condition: true
initial concentration: NaN
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110042#_f19a1cbf_9e55_487a_a7af_a32e06c74b83
is: O94777
boundary condition: true
is encoded by: hsa:8818
initial amount: NaN
has only substance units: false
is: SBO:0000252
name: DPM2
constant: false
initial concentration: NaN
type: Species

http://identifiers.org/biomodels.db/MODEL1310110042#_cd1dad58_d957_411d_9934_ff72c067ff4c
is encoded by: hsa:491
type: Species
initial concentration: NaN
is: SBO:0000252
name: ATP2B2
boundary condition: true
constant: false
is: Q4J699
has only substance units: false
initial amount: NaN

metaM hdd2coa x
name: (E)-hexadec-2-enoyl-CoA(4-)
notes: FORMULA: C37H60N7O17P3S CHARGE: -4 INCHI: InChI=1S/C37H64N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-28(46)65-21-20-39-27(45)18-19-40-35(49)32(48)37(2,3)23-58-64(55,56)61-63(53,54)57-22-26-31(60-62(50,51)52)30(47)36(59-26)44-25-43-29-33(38)41-24-42-34(29)44/h16-17,24-26,30-32,36,47-48H,4-15,18-23H2,1-3H3,(H,39,45)(H,40,49)(H,53,54)(H,55,56)(H2,38,41,42)(H2,50,51,52)/p-4/b17-16+/t26-,30-,31-,32+,36-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01411 EHMN_ABBREVIATION: C05272
is: CHEBI:61526
initial amount: NaN
boundary condition: false
is: SBO:0000247
is: HMDB03945
initial concentration: 1.0
constant: false
type: Species
has only substance units: false

metaM prostge1 e
is: HMDB01442
initial concentration: 1.0
is: SBO:0000247
notes: FORMULA: C20H33O5 CHARGE: -1 INCHI: InChI=1S/C20H34O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h12-13,15-17,19,21,23H,2-11,14H2,1H3,(H,24,25)/p-1/b13-12+/t15-,16+,17+,19+/m0/s1 EHMN_ABBREVIATION: C04741
initial amount: NaN
constant: false
type: Species
is: CHEBI:57397
name: prostaglandin E1(1-)
has only substance units: false
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110042#_143287b1_b69e_4a4f_a67a_5bdfbb3dc566
is: O95427
type: Species
initial concentration: NaN
is encoded by: hsa:23556
initial amount: NaN
name: PIGN
constant: false
is: SBO:0000252
has only substance units: false
boundary condition: true

metaM 2dr5p c
boundary condition: false
constant: false
has only substance units: false
initial concentration: 1.0
initial amount: NaN
is: HMDB01031
is: CHEBI:57651
is: SBO:0000247
name: 2-deoxy-D-ribose 5-phosphate(2-)
type: Species
notes: FORMULA: C5H9O7P CHARGE: -2 INCHI: InChI=1S/C5H11O7P/c6-2-1-4(7)5(8)3-12-13(9,10)11/h2,4-5,7-8H,1,3H2,(H2,9,10,11)/p-2/t4-,5+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00490 EHMN_ABBREVIATION: C00673

metaM mlthf m
is: CHEBI:15636
name: 5,10-Methylenetetrahydrofolate
is: SBO:0000247
constant: false
has only substance units: false
notes: FORMULA: C20H21N7O6 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00140 EHMN_ABBREVIATION: C00143
type: Species
boundary condition: false
is: C00143
is: HMDB01533
initial amount: NaN
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110042#_03e5ecff_0309_4074_849c_edb16e69a4bc
constant: false
initial amount: NaN
has only substance units: false
is encoded by: hsa:8760
is: SBO:0000252
initial concentration: NaN
is: O95674
name: CDS2
type: Species
boundary condition: true

metaM dhcholestanate x
is: SBO:0000247
name: 3alpha,7alpha-Dihydroxy-5beta-cholestanate
type: Species
boundary condition: false
notes: FORMULA: C27H45O4 CHARGE: -1 INCHI: InChI=1S/C27H46O4/c1-16(6-5-7-17(2)25(30)31)20-8-9-21-24-22(11-13-27(20,21)4)26(3)12-10-19(28)14-18(26)15-23(24)29/h16-24,28-29H,5-15H2,1-4H3,(H,30,31)/t16-,17?,18+,19-,20-,21+,22+,23-,24+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01313 EHMN_ABBREVIATION: C04554
is: CHEBI:16577
initial amount: NaN
is: HMDB00359
constant: false
has only substance units: false
initial concentration: 1.0

metaM 2maacoa m
type: Species
initial amount: NaN
constant: false
name: 2-methylacetoacetyl-CoA(4-)
boundary condition: false
is: SBO:0000247
is: CHEBI:57335
notes: FORMULA: C26H38N7O18P3S CHARGE: -4 INCHI: InChI=1S/C26H42N7O18P3S/c1-13(14(2)34)25(39)55-8-7-28-16(35)5-6-29-23(38)20(37)26(3,4)10-48-54(45,46)51-53(43,44)47-9-15-19(50-52(40,41)42)18(36)24(49-15)33-12-32-17-21(27)30-11-31-22(17)33/h11-13,15,18-20,24,36-37H,5-10H2,1-4H3,(H,28,35)(H,29,38)(H,43,44)(H,45,46)(H2,27,30,31)(H2,40,41,42)/p-4/t13?,15-,18-,19-,20+,24-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01101 EHMN_ABBREVIATION: C03344
initial concentration: 1.0
is: HMDB01157
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110042#_0b7cace0_f32c_4d47_82d7_163a6f3f521b
is encoded by: hsa:2678
name: GGT1
boundary condition: true
type: Species
has only substance units: false
constant: false
initial concentration: NaN
is: SBO:0000252
initial amount: NaN

metaR XYLTD Dr
is: SBO:0000176
type: Reaction
reversible: true
kinetic law: MODEL1310110042#
name: xylitol dehydrogenase (D-xyulose-forming)
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Pentose phosphate pathway EC Number: 1.1.1.9 Confidence Level: 2 AUTHORS: PMID:6821187 NOTES:
product: MODEL1310110042#
is described by: ECO:0000000
reactant: MODEL1310110042#

metaM xol7ah2al m
initial concentration: 1.0
is: SBO:0000247
boundary condition: false
notes: FORMULA: C27H46O3 CHARGE: 0 INCHI: InChI=1S/C27H46O3/c1-17(16-28)6-5-7-18(2)21-8-9-22-25-23(11-13-27(21,22)4)26(3)12-10-20(29)14-19(26)15-24(25)30/h16-25,29-30H,5-15H2,1-4H3/t17?,18-,19+,20-,21-,22+,23+,24-,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01454 EHMN_ABBREVIATION: C05445
is: HMDB06894
type: Species
initial amount: NaN
name: 3alpha,7alpha-dihydroxy-5beta-cholestan-26-al
has only substance units: false
constant: false
is: CHEBI:27428

metaM HC02180 c
type: Species
is: SBO:0000247
constant: false
is: CHEBI:28728
has only substance units: false
notes: FORMULA: C20H33O6 CHARGE: -1 INCHI: InChI=1S/C20H34O6/c1-2-3-6-9-15(21)12-13-18-16(17(22)14-20(25)26-18)10-7-4-5-8-11-19(23)24/h4,7,12-13,15-18,20-22,25H,2-3,5-6,8-11,14H2,1H3,(H,23,24)/b7-4-,13-12+/t15-,16-,17-,18+,20?/m0/s1 EHMN_ABBREVIATION: C05963
name: thromboxane-b2
initial concentration: 1.0
boundary condition: false
initial amount: NaN

metaM glyc R m
initial amount: NaN
is: SBO:0000247
initial concentration: 1.0
type: Species
is: CHEBI:16659
has only substance units: false
notes: FORMULA: C3H5O4 CHARGE: -1 INCHI: InChI=1S/C3H6O4/c4-1-2(5)3(6)7/h2,4-5H,1H2,(H,6,7)/p-1/t2-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00235
is: HMDB00139
constant: false
boundary condition: false
name: D-glycerate

metaR R group phosphotase 1
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: Confidence Level: AUTHORS: NOTES:
reversible: false
type: Reaction
is described by: ECO:0000000
fast: false
name: R group phosphotase 1
reactant: MODEL1310110042#
product: MODEL1310110042#
kinetic law: MODEL1310110042#

http://identifiers.org/biomodels.db/MODEL1310110042#_d368fa24_e212_41cc_abcd_c69838a6d1ec
is encoded by: hsa:11332
is: SBO:0000252
has only substance units: false
name: ACOT7
initial amount: NaN
is: O00154
boundary condition: true
constant: false
type: Species
initial concentration: NaN

metaR LEUt5m
kinetic law: MODEL1310110042#
reactant: MODEL1310110042#
name: leucine mitochondrial transport
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:11004451 NOTES:MM
reversible: true
fast: false
product: MODEL1310110042#
is described by: ECO:0000000
is: SBO:0000185
type: Reaction

metaR EX lnlncg LPAREN e RPAREN
kinetic law: MODEL1310110042#
reactant: MODEL1310110042#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: gamma-linolenic acid exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110042#_19c74c63_7e52_4467_9c9f_cd460e511a38
is: SBO:0000252
type: Species
is: P08195
initial amount: NaN
is encoded by: hsa:6520
initial concentration: NaN
boundary condition: true
has only substance units: false
constant: false
name: SLC3A2

metaM Rtotal3 e
name: R total 3 position
is: SBO:0000247
is: HMDB00244
initial concentration: 1.0
initial amount: NaN
is: C00255
constant: false
boundary condition: false
is: CHEBI:3554
type: Species
has only substance units: false
notes: FORMULA: CO2FULLR3 CHARGE: -1

metaR ARACHCPT2
reactant: MODEL1310110042#
modifier: MODEL1310110042#
type: Reaction
reversible: false
is described by: ECO:0000000
kinetic law: MODEL1310110042#
product: MODEL1310110042#
fast: false
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.3.1.21
notes: GENE_ASSOCIATION: (1376.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: NOTES:NJ
name: carnitine transferase

metaR ACNAMtn
reactant: MODEL1310110042#
is: SBO:0000185
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD
name: N-acetylneuraminate nuclear import
fast: false
reversible: false
is described by: ECO:0000000
kinetic law: MODEL1310110042#
product: MODEL1310110042#

metaR NACHEX23ly
is version of: http://identifiers.org/ec-code/3.2.1.52
is: SBO:0000176
kinetic law: MODEL1310110042#
is described by: ECO:0000000
name: beta-N-acetylhexosaminidase, lysosomal
fast: false
reactant: MODEL1310110042#
product: MODEL1310110042#
reversible: false
type: Reaction
notes: GENE_ASSOCIATION: (3073.1 and 3074.1) or (3073.1) or (3074.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.52 Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12706724,PMID:8993162 NOTES:NCD
modifier: MODEL1310110042#

metaM 4mzym int1 r
type: Species
notes: FORMULA: C29H46O3 CHARGE: 0 INCHI: InChI=1/C29H46O3/c1-18(2)8-7-9-19(3)21-11-12-22-20-10-13-24-28(5,23(20)14-16-27(21,22)4)17-15-25(30)29(24,6)26(31)32/h8,19,21-22,24-25,30H,7,9-17H2,1-6H3,(H,31,32)/t19-,21?,22?,24?,25-,27+,28+,29-/m0/s1
is: HMDB06927
is: SBO:0000247
constant: false
has only substance units: false
boundary condition: false
name: 4-Methylzymosterol intermediate 1
initial concentration: 1.0
initial amount: NaN

metaR LACZe
reversible: false
type: Reaction
name: b-galactosidase, extracellular
fast: false
product: MODEL1310110042#
notes: GENE_ASSOCIATION: (3938.1) SUBSYSTEM: Galactose metabolism EC Number: 3.2.1.23 Confidence Level: 0 AUTHORS: PMID:5774109 NOTES:Some enzymes in this group hydrolyse a-L-arabinosides; some animal enzymes also hydrolyse b-D-fucosides and b-D-glucosides; cf. EC 3.2.1.108 lactase
is: SBO:0000176
modifier: MODEL1310110042#
reactant: MODEL1310110042#
is version of: http://identifiers.org/ec-code/3.2.1.108
is described by: ECO:0000134
kinetic law: MODEL1310110042#

http://identifiers.org/biomodels.db/MODEL1310110042#_26c17fac_1825_404c_b03b_0acae429c29c
is: SBO:0000252
boundary condition: true
constant: false
initial concentration: NaN
initial amount: NaN
has only substance units: false
is encoded by: hsa:57835
type: Species
name: SLC4A5

http://identifiers.org/biomodels.db/MODEL1310110042#_b0e2d625_cdf6_4a92_83f7_9f80d5e5a8f7
is: Q7Z364
has only substance units: false
initial concentration: NaN
is encoded by: hsa:5153
constant: false
boundary condition: true
type: Species
initial amount: NaN
name: PDE1B
is: SBO:0000252

metaR PYDAMK
modifier: MODEL1310110042#
kinetic law: MODEL1310110042#
name: pyridoxamine kinase
is: SBO:0000176
reversible: false
is version of: http://identifiers.org/ec-code/2.7.1.35
fast: false
product: MODEL1310110042#
notes: GENE_ASSOCIATION: (8566.1) SUBSYSTEM: Vitamin B6 metabolism EC Number: Confidence Level: 4 AUTHORS: NOTES:
type: Reaction
is described by: ECO:0000269
reactant: MODEL1310110042#

metaR PROSTGE1t
notes: GENE_ASSOCIATION: (6578.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12507753,PMID:8787677,PMID:9334206 NOTES:NJ
fast: false
name: prostaglandin transport via bicarbonate countertransport
product: MODEL1310110042#
reactant: MODEL1310110042#
type: Reaction
is: SBO:0000185
is described by: ECO:0000269
modifier: MODEL1310110042#
reversible: true
kinetic law: MODEL1310110042#

metaM ach e
boundary condition: false
has only substance units: false
name: acetylcholine
notes: FORMULA: C7H16NO2 CHARGE: 1 INCHI: InChI=1S/C7H16NO2/c1-7(9)10-6-5-8(2,3)4/h5-6H2,1-4H3/q+1 HEPATONET_1.0_ABBREVIATION: HC00877 EHMN_ABBREVIATION: C01996
initial concentration: 1.0
is: HMDB00895
type: Species
is: SBO:0000247
constant: false
is: CHEBI:15355
initial amount: NaN

metaR PMEVKc
reversible: false
modifier: MODEL1310110042#
is version of: http://identifiers.org/ec-code/2.7.4.2
reactant: MODEL1310110042#
fast: false
type: Reaction
is: SBO:0000176
product: MODEL1310110042#
notes: GENE_ASSOCIATION: (10654.1) SUBSYSTEM: Squalene and cholesterol synthesis EC Number: Confidence Level: 4 AUTHORS: Davidson, N. O., Magun, A. M. and Glickman, R. M. 2011. Enterocyte Lipid Absorption and Secretion. Comprehensive Physiology. 505?526, PMID: 17015489, PMID: 18216769, PMID: 6833883, PMID: 11229876. NOTES:Enterocytes stand next to liver in endogenous cholesterol synthesis. in rats they provide 25% of bodys cholesterol. the crypt epithelial cells synthesize maximum cholesterol when compared to other parts of the GI tract (PMCID: PMC292609). Reactions till farnesyl pyrophosphate operates in cytosol, however, further steps including squalene synthase operates in E.R (Harpers illustrated Biochemistry (2009) 28th edition, Lange medical publications, chapter 26, page 224-227). all the cholesterol synthesis enzymes have also been found in peroxisomes (PMID: 12121718), no evidence for enterocyte sub-cellular sites, so cytosolic reactions have been added according to Harper book. one proton added to substrate for elemental balancing.
is described by: ECO:0000134
kinetic law: MODEL1310110042#
name: phosphomevalonate kinase, cytosol

metaR NDPK4n
type: Reaction
notes: GENE_ASSOCIATION: (4831.1 and 4830.1) or (4830.2 and 4831.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.6 Confidence Level: 4 AUTHORS: PMID:7050910 NOTES:Many nucleoside diphosphates (eight described) can act as acceptors. While many ribo- and deoxyribonucleoside triphosphates can act as donors, only ATP is chosen as a donor to minimize the number of total reactions.. Presence in the nucleus
is version of: http://identifiers.org/ec-code/2.7.4.6
name: nucleoside-diphosphate kinase (ATP:dTDP), nuclear
is: SBO:0000176
reversible: true
modifier: MODEL1310110042#
fast: false
reactant: MODEL1310110042#
is described by: ECO:0000304
kinetic law: MODEL1310110042#
product: MODEL1310110042#

http://identifiers.org/biomodels.db/MODEL1310110042#_179faa24_57ef_45ec_a057_6b55de513042
type: Species
boundary condition: true
initial concentration: NaN
is: SBO:0000252
name: ACADS
is encoded by: hsa:35
has only substance units: false
is: P16219
initial amount: NaN
constant: false

metaR NRPPHRSFt
name: norepinephrine sulfate transport (diffusion)
type: Reaction
fast: false
kinetic law: MODEL1310110042#
is: SBO:0000185
is described by: ECO:0000000
reversible: false
reactant: MODEL1310110042#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 1 AUTHORS: NOTES:SAB
product: MODEL1310110042#

http://identifiers.org/biomodels.db/MODEL1310110042#_771030a8_9641_42bf_9493_78b21b32a9af
initial amount: NaN
is: SBO:0000252
boundary condition: true
name: ST3GAL3
is: Q5T4W8
has only substance units: false
is encoded by: hsa:6487
constant: false
initial concentration: NaN
type: Species

metaM HC02175 e
initial concentration: 1.0
boundary condition: false
constant: false
has only substance units: false
is: CHEBI:27689
name: caprate
is: SBO:0000247
type: Species
initial amount: NaN
notes: FORMULA: C10H19O2 CHARGE: -1 INCHI: InChI=1S/C10H20O2/c1-2-3-4-5-6-7-8-9-10(11)12/h2-9H2,1H3,(H,11,12)/p-1

metaR 4NPHSULT
type: Reaction
modifier: MODEL1310110042#
product: MODEL1310110042#
reversible: false
is: SBO:0000176
name: 4-Nitrophenol Sulfotransferase
notes: GENE_ASSOCIATION: (6799.1) or (6817.3) or (6799.2) or (6818.2) or (6817.2) or (6818.1) or (6817.1) or (6817.4) or (6818.3) or (6817.5) SUBSYSTEM: Cytochrome metabolism EC Number: 2.8.2.1 Confidence Level: 4 AUTHORS: PMID:11535246,PMID:15293241 NOTES:RS/TV (6/14/05)
is described by: ECO:0000269
kinetic law: MODEL1310110042#
is version of: http://identifiers.org/ec-code/2.8.2.1
reactant: MODEL1310110042#
fast: false

metaR APPNNte
is described by: ECO:0000000
fast: false
is: SBO:0000185
reactant: MODEL1310110042#
product: MODEL1310110042#
reversible: true
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:unknown mechanism, xenobiotic transport (original and metabolized) NJ
name: xenobiotic transport
kinetic law: MODEL1310110042#

metaR ARACHCPT1
kinetic law: MODEL1310110042#
name: carnitine transferase
modifier: MODEL1310110042#
fast: false
is version of: http://identifiers.org/ec-code/2.3.1.21
product: MODEL1310110042#
type: Reaction
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (1375.3) or (1374.1) or (1375.2) or (1375.4) or (1375.1) or (126129.1) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.21 Confidence Level: 4 AUTHORS: NOTES:NJ
reactant: MODEL1310110042#
reversible: false
is: SBO:0000176

metaR RE2660C
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Tetrahydrobiopterin metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:9647871 NOTES:
is: SBO:0000176
reactant: MODEL1310110042#
name: RE2660
type: Reaction
fast: false
kinetic law: MODEL1310110042#
is described by: ECO:0000000
product: MODEL1310110042#

metaM vacccoa c
boundary condition: false
is: SBO:0000247
is: HMDB06521
is: http://identifiers.org/pubchem.compound/9543677
initial concentration: 1.0
initial amount: NaN
name: vaccenyl coenzyme A
has only substance units: false
constant: false
notes: FORMULA: C39H64N7O17P3S CHARGE: -4 INCHI: InChI=1/C39H68N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-30(48)67-23-22-41-29(47)20-21-42-37(51)34(50)39(2,3)25-60-66(57,58)63-65(55,56)59-24-28-33(62-64(52,53)54)32(49)38(61-28)46-27-45-31-35(40)43-26-44-36(31)46/h9-10,26-28,32-34,38,49-50H,4-8,11-25H2,1-3H3,(H,41,47)(H,42,51)(H,55,56)(H,57,58)(H2,40,43,44)(H2,52,53,54)/b10-9+/t28-,32-,33?,34+,38-/m1/s1
type: Species

metaM HC02180 e
is: SBO:0000247
constant: false
type: Species
is: CHEBI:28728
name: thromboxane-b2
has only substance units: false
notes: FORMULA: C20H33O6 CHARGE: -1 INCHI: InChI=1S/C20H34O6/c1-2-3-6-9-15(21)12-13-18-16(17(22)14-20(25)26-18)10-7-4-5-8-11-19(23)24/h4,7,12-13,15-18,20-22,25H,2-3,5-6,8-11,14H2,1H3,(H,23,24)/b7-4-,13-12+/t15-,16-,17-,18+,20?/m0/s1 EHMN_ABBREVIATION: C05963
initial amount: NaN
initial concentration: 1.0
boundary condition: false

metaR CLOXAtex2
product: MODEL1310110042#
notes: GENE_ASSOCIATION: (65010.1) or (65010.3) or (65010.2) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:12759755 NOTES:SAB
modifier: MODEL1310110042#
name: chloride transport via oxalate countertransport (2:1)
is described by: ECO:0000304
fast: false
is: SBO:0000185
kinetic law: MODEL1310110042#
reversible: false
type: Reaction
reactant: MODEL1310110042#

metaM taur x
initial amount: NaN
is: SBO:0000247
is: HMDB00251
initial concentration: 1.0
is: CHEBI:15891
constant: false
type: Species
name: taurine
boundary condition: false
has only substance units: false
notes: FORMULA: C2H7NO3S CHARGE: 0 INCHI: InChI=1S/C2H7NO3S/c3-1-2-7(4,5)6/h1-3H2,(H,4,5,6) HEPATONET_1.0_ABBREVIATION: HC00222 EHMN_ABBREVIATION: C00245

http://identifiers.org/biomodels.db/MODEL1310110042#_47a76dab_47e3_4864_8217_3f1bc0f1d42b
is encoded by: hsa:5476
has part: Q99519
type: Species
is: SBO:0000297
name: GALNS:GLB1:NEU1:CTSA
has part: P10619
is encoded by: hsa:2720
constant: false
boundary condition: true
has part: P16278
has part: P34059
initial amount: NaN
has only substance units: false
initial concentration: NaN
is encoded by: hsa:2588
is encoded by: hsa:4758

http://identifiers.org/biomodels.db/MODEL1310110042#_56de284e_4ec0_493e_b9f7_0739ee862754
initial concentration: NaN
is encoded by: hsa:2222
is: SBO:0000252
name: FDFT1
initial amount: NaN
type: Species
has only substance units: false
boundary condition: true
is: P37268
constant: false

metaM n2m2nm l
name: n2m2nmasn (w/o peptide linkage)
initial amount: NaN
notes: FORMULA: C58H97N5O41 CHARGE: 0
constant: false
is: CHEBI:30825
initial concentration: 1.0
boundary condition: false
type: Species
is: HMDB00573
has only substance units: false
is: SBO:0000247

metaM r5p r
constant: false
is: SBO:0000247
boundary condition: false
initial concentration: 1.0
name: alpha-D-Ribose 5-phosphate
type: Species
initial amount: NaN
has only substance units: false
notes: FORMULA: C5H9O8P CHARGE: -2 INCHI: InChI=1S/C5H11O8P/c6-3-2(1-12-14(9,10)11)13-5(8)4(3)7/h2-8H,1H2,(H2,9,10,11)/t2-,3-,4-,5+/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00115 EHMN_ABBREVIATION: C00117
is: CHEBI:18189
is: HMDB00618

http://identifiers.org/biomodels.db/MODEL1310110042#_c4f2f282_7a83_4702_9037_16d364e47f9f
initial concentration: NaN
type: Species
boundary condition: true
has only substance units: false
is: SBO:0000252
constant: false
is encoded by: hsa:23600
initial amount: NaN
is: Q3KT79
name: AMACR

metaR r2055
reactant: MODEL1310110042#
modifier: MODEL1310110042#
is described by: ECO:0000000
reversible: false
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
kinetic law: MODEL1310110042#
product: MODEL1310110042#
is: SBO:0000185
type: Reaction
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.15
fast: false

http://identifiers.org/biomodels.db/MODEL1310110042#_bd917338_533e_4d18_9f0e_43dbbe0d9af8
name: PLA2G5
is encoded by: hsa:5322
initial amount: NaN
boundary condition: true
is: SBO:0000252
constant: false
type: Species
has only substance units: false
is: P39877
initial concentration: NaN

metaR GLNtm
fast: false
product: MODEL1310110042#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: NOTES:TV (6/7/2005) Study in rat liver (Soboll, 1991)
reversible: false
kinetic law: MODEL1310110042#
is described by: ECO:0000000
type: Reaction
is: SBO:0000185
name: L-glutamine transport via electroneutral transporter
reactant: MODEL1310110042#

http://identifiers.org/biomodels.db/MODEL1310110042#_ab1185b5_8138_4b66_9ca6_f680c111ec09
has only substance units: false
initial concentration: NaN
constant: false
name: SLC25A10
is encoded by: hsa:1468
boundary condition: true
initial amount: NaN
is: Q9UBX3
is: SBO:0000252
type: Species

metaR AMETt2m
reversible: true
modifier: MODEL1310110042#
kinetic law: MODEL1310110042#
type: Reaction
is: SBO:0000185
notes: GENE_ASSOCIATION: (115286.3) or (115286.2) or (115286.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14674884 NOTES:Added by RS/TV (6/17/05)
is described by: ECO:0000269
fast: false
name: S-Adenosyl-L-methionine reversible transport, mitochondrial
product: MODEL1310110042#
reactant: MODEL1310110042#

metaM bilirub r
name: bilirubin(2-)
type: Species
has only substance units: false
constant: false
is: CHEBI:57977
initial amount: NaN
is: SBO:0000247
notes: FORMULA: C33H34N4O6 CHARGE: -2 INCHI: InChI=1S/C33H36N4O6/c1-7-20-19(6)32(42)37-27(20)14-25-18(5)23(10-12-31(40)41)29(35-25)15-28-22(9-11-30(38)39)17(4)24(34-28)13-26-16(3)21(8-2)33(43)36-26/h7-8,13-14,34-35H,1-2,9-12,15H2,3-6H3,(H,36,43)(H,37,42)(H,38,39)(H,40,41)/p-2/b26-13-,27-14- HEPATONET_1.0_ABBREVIATION: HC00385 EHMN_ABBREVIATION: C00486
initial concentration: 1.0
boundary condition: false
is: HMDB00054

metaR r2344
is: SBO:0000185
kinetic law: MODEL1310110042#
product: MODEL1310110042#
type: Reaction
reversible: true
fast: false
is described by: ECO:0000000
reactant: MODEL1310110042#
name: Organic anion transporter 5 Utilized transport
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:

metaR DINt
fast: false
name: deoxyinosine transport via diffusion
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10899995 NOTES:
is described by: ECO:0000000
reactant: MODEL1310110042#
product: MODEL1310110042#
type: Reaction
kinetic law: MODEL1310110042#
is: SBO:0000185
reversible: true

metaR r2128
product: MODEL1310110042#
modifier: MODEL1310110042#
reversible: true
kinetic law: MODEL1310110042#
is: SBO:0000185
type: Reaction
is described by: ECO:0000000
fast: false
reactant: MODEL1310110042#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
name: Major Facilitator(MFS) TCDB:2.A.1.13.1

metaR r1433
reactant: MODEL1310110042#
name: NADPH:oxidized-thioredoxin oxidoreductase Pyrimidine metabolism EC:1.8.1.9
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 1.8.1.9 Confidence Level: 0 AUTHORS: PMID:5553404,PMID:5671058 NOTES:
type: Reaction
reversible: false
is: SBO:0000176
is described by: ECO:0000000
product: MODEL1310110042#
kinetic law: MODEL1310110042#
fast: false

metaM leuktrF4 e
notes: FORMULA: C28H42N2O8S CHARGE: -2 INCHI: InChI=1S/C28H44N2O8S/c1-2-3-4-5-6-7-8-9-10-11-12-13-16-24(23(31)15-14-17-26(33)34)39-20-22(28(37)38)30-25(32)19-18-21(29)27(35)36/h6-7,9-13,16,21-24,31H,2-5,8,14-15,17-20,29H2,1H3,(H,30,32)(H,33,34)(H,35,36)(H,37,38)/b7-6-,10-9-,12-11+,16-13+/t21-,22+,23+,24-/m1/s1
constant: false
initial concentration: 1.0
has only substance units: false
is: HMDB06465
type: Species
is: CHEBI:27491
is: SBO:0000247
boundary condition: false
name: leukotriene F4
initial amount: NaN

metaR G14T21g
kinetic law: MODEL1310110042#
is version of: http://identifiers.org/ec-code/2.4.1.22
product: MODEL1310110042#
type: Reaction
reactant: MODEL1310110042#
is version of: http://identifiers.org/ec-code/2.4.1.38
modifier: MODEL1310110042#
name: beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase, Golgi
fast: false
notes: GENE_ASSOCIATION: (8703.1) or (2683.1) or (8704.2) or (8704.1) or (9334.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.38 Confidence Level: 4 AUTHORS: PMID:10747980,PMID:12512857,PMID:3094506,PMID:3144273,PMID:9405390,PMID:9435216 NOTES:Keratan sulfate II biosynthesis NCD
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/2.4.1.90
is: SBO:0000176
reversible: false

metaR LEUKTRF4t
kinetic law: MODEL1310110042#
is: SBO:0000185
reactant: MODEL1310110042#
reversible: true
name: leukotriene F4 transport
fast: false
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:
product: MODEL1310110042#
is described by: ECO:0000000

metaM gluside hs r
type: Species
initial concentration: 1.0
has only substance units: false
is: SBO:0000247
initial amount: NaN
notes: FORMULA: C24H46NO7FULLRCO CHARGE: 0 EHMN_ABBREVIATION: C01190
boundary condition: false
is: CHEBI:18368
name: D-glucosyl-N-acylsphingosine
constant: false

metaM apoC Lys btn c
boundary condition: false
notes: FORMULA: C16H27N4O3SX CHARGE: 0
constant: false
has only substance units: false
type: Species
name: Holocarboxylase (biotin covalent bound to Lys residue of apoC)
initial amount: NaN
is: SBO:0000247
is: HMDB00182
is: CHEBI:32551
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110042#_d25a4bfb_27bf_4b21_ace2_b7514f83a3d8
initial concentration: NaN
has only substance units: false
constant: false
initial amount: NaN
is encoded by: hsa:5152
name: PDE9A
boundary condition: true
is: SBO:0000252
type: Species

metaM adpac x
is: SBO:0000247
initial amount: NaN
has only substance units: false
boundary condition: false
initial concentration: 1.0
name: adipic acid
notes: FORMULA: C6H8O4 CHARGE: -2
constant: false
is: HMDB00448
type: Species

metaR r0480
reactant: MODEL1310110042#
product: MODEL1310110042#
name: S-Adenosyl-L-methionine:ethanolamine-phosphate N-methyltransferase Glycerophospholipid metabolism EC:2.1.1.103
type: Reaction
is: SBO:0000176
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Glycerophospholipid metabolism EC Number: 2.1.1.103 Confidence Level: 0 AUTHORS: PMID:2403362 NOTES:
kinetic law: MODEL1310110042#
reversible: true
fast: false

metaM g1m8masn r
notes: FORMULA: C76H127N2O60X CHARGE: 0
initial amount: NaN
constant: false
is: SBO:0000247
has only substance units: false
is: C05875
boundary condition: false
initial concentration: 1.0
name: (alpha-D-Glucosyl)-(alpha-D-mannosyl)8-beta-D-mannosyl-diacetylchitobiosyl-L-asparagine (protein)
type: Species

http://identifiers.org/biomodels.db/MODEL1310110042#_9109aee5_3dc4_4da2_a4d8_17911ca9b112
has only substance units: false
constant: false
is encoded by: hsa:1632
boundary condition: true
name: ECI1
initial concentration: NaN
type: Species
initial amount: NaN
is: P42126
is: SBO:0000252

metaR MDH
type: Reaction
fast: false
kinetic law: MODEL1310110042#
modifier: MODEL1310110042#
reversible: true
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.1.1.37
is described by: ECO:0000134
notes: GENE_ASSOCIATION: (130752.1) or (4190.1) SUBSYSTEM: Citric acid cycle EC Number: 1.1.1.37 Confidence Level: 0 AUTHORS: PMID:15565635,PMID:9933076 NOTES:Biochemical
product: MODEL1310110042#
name: malate dehydrogenase
reactant: MODEL1310110042#

metaR KSIt
fast: false
reactant: MODEL1310110042#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:NCD
is: SBO:0000185
kinetic law: MODEL1310110042#
product: MODEL1310110042#
reversible: false
name: keratan sulfate I transport, golgi to extracellular
type: Reaction
is described by: ECO:0000000

metaM ddsmsterol r
notes: FORMULA: C27H42O CHARGE: 0 INCHI: InChI=1S/C27H42O/c1-18(2)7-6-8-19(3)23-11-12-24-22-10-9-20-17-21(28)13-15-26(20,4)25(22)14-16-27(23,24)5/h7,9-10,19,21,23-25,28H,6,8,11-17H2,1-5H3/t19-,21+,23-,24+,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01373
has only substance units: false
initial amount: NaN
constant: false
boundary condition: false
initial concentration: 1.0
is: CHEBI:27910
type: Species
is: HMDB03896
is: SBO:0000247
name: 7-dehydrodesmosterol

http://identifiers.org/biomodels.db/MODEL1310110042#_b6ccc04c_41b5_4cc2_b179_435587eee921
is: SBO:0000252
type: Species
initial amount: NaN
has only substance units: false
constant: false
is: P00915
boundary condition: true
name: CA1
initial concentration: NaN
is encoded by: hsa:759

metaM CE0693 m
initial concentration: 1.0
constant: false
initial amount: NaN
notes: FORMULA: C33H50N7O18P3S CHARGE: -4 INCHI: InChI=1/C33H54N7O18P3S/c1-4-5-6-7-8-9-10-11-21(41)16-24(43)62-15-14-35-23(42)12-13-36-31(46)28(45)33(2,3)18-55-61(52,53)58-60(50,51)54-17-22-27(57-59(47,48)49)26(44)32(56-22)40-20-39-25-29(34)37-19-38-30(25)40/h8-9,19-20,22,26-28,32,44-45H,4-7,10-18H2,1-3H3,(H,35,42)(H,36,46)(H,50,51)(H,52,53)(H2,34,37,38)(H2,47,48,49)/p-4/b9-8-/t22-,26+,27+,28u,32-/m0/s1 EHMN_ABBREVIATION: CE0693
boundary condition: false
is: SBO:0000247
has only substance units: false
type: Species
is: CHEBI:28387
name: 3-oxolaur-6-cis-enoyl-CoA
is: HMDB11123

metaR r2129
type: Reaction
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
is described by: ECO:0000000
product: MODEL1310110042#
kinetic law: MODEL1310110042#
is: SBO:0000185
fast: false
modifier: MODEL1310110042#
reversible: true
reactant: MODEL1310110042#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110042#_a8586c19_eed6_454a_a8e2_6942f2d14e6e
has only substance units: false
initial concentration: NaN
constant: false
name: MGAT5
initial amount: NaN
boundary condition: true
is: SBO:0000252
is: Q09328
is encoded by: hsa:4249
type: Species

metaM ksi deg33 l
constant: false
is: SBO:0000247
type: Species
initial concentration: 1.0
is: CHEBI:12936
is: HMDB00143
has only substance units: false
initial amount: NaN
notes: FORMULA: C76H125N5O62S2 CHARGE: -2
name: keratan sulfate I, degradation product 33
boundary condition: false

metaR 3SPYRSPm
reactant: MODEL1310110042#
notes: GENE_ASSOCIATION: SUBSYSTEM: Methionine and cysteine metabolism EC Number: Confidence Level: 2 AUTHORS: PMID:3346220 NOTES:MM
reversible: false
is described by: ECO:0000000
fast: false
is: SBO:0000176
type: Reaction
kinetic law: MODEL1310110042#
product: MODEL1310110042#
name: 3-sulfinopyruvate hydrolase (spotaneous reaction), mitochondrial

metaM hs deg3 l
has only substance units: false
notes: FORMULA: C81H117N5O97S10 CHARGE: -12
initial amount: NaN
type: Species
boundary condition: false
initial concentration: 1.0
is: CHEBI:16126
name: heparan sulfate, degradation product 3
is: SBO:0000247
constant: false

metaR DM dgpi prot hs r
kinetic law: MODEL1310110042#
reactant: MODEL1310110042#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 0 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: false
name: DM dgpi prot hs(r)
type: Reaction

metaR r1434
kinetic law: MODEL1310110042#
fast: false
type: Reaction
name: Transport reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:12930836,PMID:16288981,PMID:911815 NOTES:
is: SBO:0000185
is described by: ECO:0000000
reactant: MODEL1310110042#
reversible: false
product: MODEL1310110042#

http://identifiers.org/biomodels.db/MODEL1310110042#_0da52cbd_93a0_4541_9020_21c080f99d94
is: P10632
is: SBO:0000252
is encoded by: hsa:1558
has only substance units: false
initial concentration: NaN
constant: false
type: Species
name: CYP2C8
boundary condition: true
initial amount: NaN

metaM 6thf e
notes: FORMULA: C44H51N12O21 CHARGE: -7 INCHI: InChI=1/C44H54N12O21/c45-21(36(66)67)5-10-26(57)43(15-30(61)62,27(58)11-6-22(46)37(68)69)44(28(59)12-7-23(47)38(70)71,41(76)77-31(63)14-9-25(49)40(74)75)56(29(60)13-8-24(48)39(72)73)35(65)18-1-3-19(4-2-18)51-16-20-17-52-33-32(53-20)34(64)55-42(50)54-33/h1-4,17,21-25,51H,5-16,45-49H2,(H,61,62)(H,66,67)(H,68,69)(H,70,71)(H,72,73)(H,74,75)(H3,50,52,54,55,64)/p-1/t21u,22u,23u,24u,25u,43u,44-/m1/s1
boundary condition: false
type: Species
initial amount: NaN
is: SBO:0000247
name: hexaglutamyl folate (THF)
is: http://identifiers.org/pubchem.compound/169691
constant: false
has only substance units: false
initial concentration: 1.0

metaR FATP8t
name: fatty acid electroneutral transport
is: SBO:0000185
reversible: true
modifier: MODEL1310110042#
kinetic law: MODEL1310110042#
product: MODEL1310110042#
is version of: http://identifiers.org/ec-code/6.2.1.7
reactant: MODEL1310110042#
type: Reaction
notes: GENE_ASSOCIATION: (10998.1) or (11001.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10479480,PMID:12856180,PMID:15522816 NOTES:electroneutral transport NJ
fast: false
is version of: http://identifiers.org/ec-code/6.2.1.3
is described by: ECO:0000269

http://identifiers.org/biomodels.db/MODEL1310110042#_f8c19c1e_8a6c_4632_8ef0_e7e7092329d2
boundary condition: true
name: PDXK
type: Species
is: SBO:0000252
constant: false
is encoded by: hsa:8566
is: O00764
initial concentration: NaN
has only substance units: false
initial amount: NaN

metaR EX dpcoa LPAREN e RPAREN
kinetic law: MODEL1310110042#
reactant: MODEL1310110042#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for dpcoa
type: Reaction

metaR FAOXC162C162OHm
kinetic law: MODEL1310110042#
product: MODEL1310110042#
reactant: MODEL1310110042#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C16:2-->C16:2OH)m
type: Reaction

metaM HC02175 c
boundary condition: false
name: caprate
type: Species
initial amount: NaN
initial concentration: 1.0
is: SBO:0000247
is: CHEBI:27689
constant: false
notes: FORMULA: C10H19O2 CHARGE: -1 INCHI: InChI=1S/C10H20O2/c1-2-3-4-5-6-7-8-9-10(11)12/h2-9H2,1H3,(H,11,12)/p-1
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110042#_74be7e85_3134_4287_846f_2f82d8702a4e
type: Species
initial amount: NaN
initial concentration: NaN
is: SBO:0000252
has only substance units: false
boundary condition: true
is encoded by: hsa:2194
is: P49327
name: FASN
constant: false

metaR BAMPPALDOX
is: SBO:0000176
kinetic law: MODEL1310110042#
fast: false
type: Reaction
is version of: http://identifiers.org/ec-code/1.2.1.3
is version of: http://identifiers.org/ec-code/1.2.1.36
product: MODEL1310110042#
reactant: MODEL1310110042#
reversible: false
notes: GENE_ASSOCIATION: (8854.2) or (501.1) or (216.1) or (224.1) or (8854.3) or (223.1) or (8854.1) SUBSYSTEM: beta-Alanine metabolism EC Number: 1.2.1.36 Confidence Level: 1 AUTHORS: PMID:12586697 NOTES:SAB
modifier: MODEL1310110042#
is described by: ECO:0000212
name: beta-Aminopropion aldehyde:NAD+ oxidoreductase

metaM ach c
initial concentration: 1.0
constant: false
name: acetylcholine
has only substance units: false
is: CHEBI:15355
initial amount: NaN
boundary condition: false
type: Species
notes: FORMULA: C7H16NO2 CHARGE: 1 INCHI: InChI=1S/C7H16NO2/c1-7(9)10-6-5-8(2,3)4/h5-6H2,1-4H3/q+1 HEPATONET_1.0_ABBREVIATION: HC00877 EHMN_ABBREVIATION: C01996
is: SBO:0000247
is: HMDB00895

metaM leuktrF4 c
has only substance units: false
initial amount: NaN
initial concentration: 1.0
constant: false
is: HMDB06465
type: Species
is: CHEBI:27491
is: SBO:0000247
boundary condition: false
name: leukotriene F4
notes: FORMULA: C28H42N2O8S CHARGE: -2 INCHI: InChI=1S/C28H44N2O8S/c1-2-3-4-5-6-7-8-9-10-11-12-13-16-24(23(31)15-14-17-26(33)34)39-20-22(28(37)38)30-25(32)19-18-21(29)27(35)36/h6-7,9-13,16,21-24,31H,2-5,8,14-15,17-20,29H2,1H3,(H,30,32)(H,33,34)(H,35,36)(H,37,38)/b7-6-,10-9-,12-11+,16-13+/t21-,22+,23+,24-/m1/s1

http://identifiers.org/biomodels.db/MODEL1310110042#_3db8c50d_f933_4b07_ba7c_45672aec2d3b
constant: false
is encoded by: hsa:79143
initial concentration: NaN
name: MBOAT7
is: Q96N66
type: Species
is: SBO:0000252
boundary condition: true
initial amount: NaN
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110042#_3c2b74a0_b3fa_49e2_9e6d_d6437e4074a1
is: O75354
type: Species
is: SBO:0000252
has only substance units: false
constant: false
initial amount: NaN
boundary condition: true
initial concentration: NaN
name: ENTPD6
is encoded by: hsa:955

metaR UPP3S
fast: false
is described by: ECO:0000000
product: MODEL1310110042#
name: uroporphyrinogen-III synthase
reversible: false
modifier: MODEL1310110042#
notes: GENE_ASSOCIATION: (7390.1) SUBSYSTEM: Heme synthesis EC Number: 4.2.1.75 Confidence Level: 0 AUTHORS: PMID:3174619 NOTES:
is: SBO:0000176
reactant: MODEL1310110042#
is version of: http://identifiers.org/ec-code/4.2.1.75
type: Reaction
kinetic law: MODEL1310110042#

metaR EX c3dc
kinetic law: MODEL1310110042#
reactant: MODEL1310110042#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for malonyl carnitine
type: Reaction

metaR IDOURte
type: Reaction
fast: false
reversible: true
product: MODEL1310110042#
kinetic law: MODEL1310110042#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000185
name: L-iduronate transport, extracellular
reactant: MODEL1310110042#

http://identifiers.org/biomodels.db/MODEL1310110042#_3bacc43f_f86b_4957_9ca5_4e540c72fd3d
type: Species
name: HSD17B10
constant: false
initial amount: NaN
is: SBO:0000252
is: Q99714
has only substance units: false
is encoded by: hsa:3028
boundary condition: true
initial concentration: NaN

metaM adp e
is: HMDB01341
is: SBO:0000247
constant: false
has only substance units: false
notes: FORMULA: C10H12N5O10P2 CHARGE: -3 INCHI: InChI=1S/C10H15N5O10P2/c11-8-5-9(13-2-12-8)15(3-14-5)10-7(17)6(16)4(24-10)1-23-27(21,22)25-26(18,19)20/h2-4,6-7,10,16-17H,1H2,(H,21,22)(H2,11,12,13)(H2,18,19,20)/p-3/t4-,6-,7-,10-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00018 EHMN_ABBREVIATION: C00008
is: CHEBI:456216
initial concentration: 1.0
boundary condition: false
type: Species
initial amount: NaN
name: ADP(3-)

http://identifiers.org/biomodels.db/MODEL1310110042#_414444d8_abf7_4fac_abbe_f44632a0c0af
constant: false
type: Species
initial amount: NaN
name: SLC37A4
initial concentration: NaN
boundary condition: true
is encoded by: hsa:2542
has only substance units: false
is: A8K0S7
is: SBO:0000252

metaR BACCLm
reversible: false
is described by: ECO:0000254
product: MODEL1310110042#
notes: GENE_ASSOCIATION: (3141.1) SUBSYSTEM: Biotin metabolism EC Number: 6.3.4.15 Confidence Level: 2 AUTHORS: PMID:12459313,PMID:7842009 NOTES:IT
reactant: MODEL1310110042#
is version of: http://identifiers.org/ec-code/6.3.4.10
type: Reaction
kinetic law: MODEL1310110042#
modifier: MODEL1310110042#
fast: false
name: biotin-[acetyl-CoA-carboxylase] ligase, mitochondrial
is: SBO:0000176

metaR ASCBt
reversible: true
is described by: ECO:0000000
reactant: MODEL1310110042#
type: Reaction
name: L-ascorbate transport via facilitated diffusion
product: MODEL1310110042#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:15705056,PMID:3715892 NOTES:NCD
fast: false
kinetic law: MODEL1310110042#

http://identifiers.org/biomodels.db/MODEL1310110042#_38c9065c_80f3_4972_9887_34b286aa1999
initial concentration: NaN
type: Species
is: Q9NRA2
boundary condition: true
has only substance units: false
is encoded by: hsa:26503
is: SBO:0000252
constant: false
initial amount: NaN
name: SLC17A5

metaR O16G1e
is version of: http://identifiers.org/ec-code/3.2.1.10
name: oligo-1,6-glucosidase (glygn4 -> glygn5), extracellular
fast: false
product: MODEL1310110042#
modifier: MODEL1310110042#
notes: GENE_ASSOCIATION: (6476.1) SUBSYSTEM: Starch and sucrose metabolism EC Number: 3.2.1.10 Confidence Level: 0 AUTHORS: NOTES:NCD
kinetic law: MODEL1310110042#
reversible: false
is described by: ECO:0000000
reactant: MODEL1310110042#
type: Reaction
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110042#_6b36aa41_6798_425a_9fa6_adf156b66d6d
is: Q9NY65
initial amount: NaN
constant: false
boundary condition: true
is: SBO:0000252
type: Species
has only substance units: false
initial concentration: NaN
name: EHHADH
is encoded by: hsa:1962

http://identifiers.org/biomodels.db/MODEL1310110042#_3e681b6e_7002_4d92_bfe7_b57ef5ef3740
is: SBO:0000252
initial concentration: NaN
constant: false
has only substance units: false
is encoded by: hsa:3032
type: Species
is: P55084
initial amount: NaN
boundary condition: true
name: HADHB

metaR r1965
name: Y+LAT2 Utilized transport
is described by: ECO:0000000
type: Reaction
reversible: false
kinetic law: MODEL1310110042#
is: SBO:0000185
reactant: MODEL1310110042#
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
modifier: MODEL1310110042#
fast: false
product: MODEL1310110042#

metaM sphings c
initial amount: NaN
boundary condition: false
has only substance units: false
notes: FORMULA: C18H38NO2 CHARGE: 1 INCHI: InChI=1S/C18H37NO2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-18(21)17(19)16-20/h14-15,17-18,20-21H,2-13,16,19H2,1H3/p+1/b15-14+/t17-,18+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00271 EHMN_ABBREVIATION: C00319
name: sphingosine(1+)
type: Species
initial concentration: 1.0
is: CHEBI:57756
is: SBO:0000247
constant: false
is: HMDB00252

metaM 3ddecdicoa m
constant: false
notes: FORMULA: C33H50N7O17P3S CHARGE: -4
has only substance units: false
initial amount: NaN
is: C05280
boundary condition: false
is: HMDB03952
is: SBO:0000247
type: Species
initial concentration: 1.0
name: 3,6-dodecadienoylcoa

metaM xol7ah2al c
initial concentration: 1.0
constant: false
type: Species
initial amount: NaN
notes: FORMULA: C27H46O3 CHARGE: 0 INCHI: InChI=1S/C27H46O3/c1-17(16-28)6-5-7-18(2)21-8-9-22-25-23(11-13-27(21,22)4)26(3)12-10-20(29)14-19(26)15-24(25)30/h16-25,29-30H,5-15H2,1-4H3/t17?,18-,19+,20-,21-,22+,23+,24-,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01454 EHMN_ABBREVIATION: C05445
is: HMDB06894
name: 3alpha,7alpha-dihydroxy-5beta-cholestan-26-al
is: CHEBI:27428
boundary condition: false
has only substance units: false
is: SBO:0000247

metaR FADH2tru
name: FADH2 transporter, endoplasmic reticulum
reactant: MODEL1310110042#
is: SBO:0000185
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: NOTES:diffusion - but unidirectional uptake into ER (to avoid loops w/ NAD/NADP) NJ
product: MODEL1310110042#
is described by: ECO:0000000
reversible: false
kinetic law: MODEL1310110042#
type: Reaction

metaR FAOXC18C18OHm
kinetic law: MODEL1310110042#
product: MODEL1310110042#
reactant: MODEL1310110042#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C18-->C18OH)m
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110042#_a4f7e352_d515_4ba1_9b7f_985f1157f6b3
boundary condition: true
constant: false
initial concentration: NaN
has only substance units: false
is: H7C5B8
is encoded by: hsa:4708
type: Species
initial amount: NaN
is: SBO:0000252
name: NDUFB2

http://identifiers.org/biomodels.db/MODEL1310110042#_98840593_f0bb_4451_b796_e483857e40f8
initial concentration: NaN
is encoded by: hsa:480
type: Species
is: SBO:0000252
name: ATP1A4
is: Q13733
boundary condition: true
initial amount: NaN
constant: false
has only substance units: false

metaR FAOXC226C225m
kinetic law: MODEL1310110042#
product: MODEL1310110042#
reactant: MODEL1310110042#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C22:6-->C22:5)m
type: Reaction

metaR r2341
kinetic law: MODEL1310110042#
name: Organic anion transporter 5 Utilized transport
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
type: Reaction
is: SBO:0000185
product: MODEL1310110042#
is described by: ECO:0000000
reversible: true
reactant: MODEL1310110042#

http://identifiers.org/biomodels.db/MODEL1310110042#_dec27e6f_2838_4b64_8fd2_5ef76f2b16f3
has only substance units: false
is encoded by: hsa:6307
is: A8MYF6
initial concentration: NaN
name: MSMO1
constant: false
type: Species
boundary condition: true
is: SBO:0000252
initial amount: NaN

metaM 5adtststerones c
initial amount: NaN
boundary condition: false
constant: false
name: 5alpha-Dihydrotestosterone sulfate
initial concentration: 1.0
is: SBO:0000247
type: Species
has only substance units: false
is: HMDB06278
notes: FORMULA: C19H29O5S CHARGE: -1 INCHI: InChI=1/C19H30O5S/c1-18-9-7-13(20)11-12(18)3-4-14-15-5-6-17(24-25(21,22)23)19(15,2)10-8-16(14)18/h12,14-17H,3-11H2,1-2H3,(H,21,22,23)/t12-,14-,15-,16-,17-,18-,19-/m0/s1 EHMN_ABBREVIATION: CE6032

http://identifiers.org/biomodels.db/MODEL1310110042#_ea7cff35_42ce_45e6_a7b9_da838e7370ea
is: Q16836
boundary condition: true
is encoded by: hsa:3033
name: HADH
initial amount: NaN
has only substance units: false
type: Species
is: SBO:0000252
constant: false
initial concentration: NaN

metaM n4m2masn g
type: Species
initial amount: NaN
constant: false
notes: FORMULA: C66H109N6O45X CHARGE: 0
name: ((N-acetyl-D-glucosaminyl)4-(alpha-D-mannosyl)2-beta-D-mannosyl-diacetylchitobiosyl)-L-asparagine (protein)
is: C05881
has only substance units: false
boundary condition: false
is: SBO:0000247
initial concentration: 1.0

metaR DOLPGT2 Ler
is described by: ECO:0000000
reactant: MODEL1310110042#
kinetic law: MODEL1310110042#
name: dolichyl-phosphate-glucose-glycolipid alpha-glucosyltransferase (liver)
notes: GENE_ASSOCIATION: (79053.1) or (79053.3) or (79053.2) SUBSYSTEM: N-glycan synthesis EC Number: Confidence Level: 0 AUTHORS: NOTES:EC 2.4.1.- NCD
is: SBO:0000176
modifier: MODEL1310110042#
product: MODEL1310110042#
type: Reaction
fast: false
is version of: http://identifiers.org/ec-code/2.4.1.265
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110042#_7ed6f4b5_a408_41dd_87ca_78d9b3c87739
is: P21399
has only substance units: false
name: ACO1
constant: false
initial amount: NaN
boundary condition: true
initial concentration: NaN
type: Species
is encoded by: hsa:48
is: SBO:0000252

metaR r2124
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
modifier: MODEL1310110042#
fast: false
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
reactant: MODEL1310110042#
type: Reaction
reversible: true
kinetic law: MODEL1310110042#
is: SBO:0000185
is described by: ECO:0000000
product: MODEL1310110042#

http://identifiers.org/biomodels.db/MODEL1310110042#_98bfd5c0_7356_48e1_88d1_849d50b8ae2f
is encoded by: hsa:8706
has only substance units: false
constant: false
is: Q8TDY1
is: SBO:0000252
boundary condition: true
name: B3GALNT1
initial concentration: NaN
initial amount: NaN
type: Species

metaM m4mpdol U c
boundary condition: false
notes: FORMULA: C1485H2440N20O420P20 CHARGE: -20 INCHI: InChI=1S/C71H122N2O42P2/c1-30(2)13-9-14-31(3)15-10-16-32(4)17-11-18-33(5)19-12-20-34(6)21-22-101-116(96,97)115-117(98,99)114-66-45(73-36(8)81)52(88)60(42(28-79)107-66)109-65-44(72-35(7)80)51(87)61(41(27-78)106-65)110-69-59(95)62(50(86)43(108-69)29-100-67-57(93)53(89)46(82)37(23-74)102-67)111-70-64(56(92)49(85)39(25-76)104-70)113-71-63(55(91)48(84)40(26-77)105-71)112-68-58(94)54(90)47(83)38(24-75)103-68/h13,15,17,19,34,37-71,74-79,82-95H,9-12,14,16,18,20-29H2,1-8H3,(H,72,80)(H,73,81)(H,96,97)(H,98,99)/b31-15+,32-17+,33-19+/t34?,37-,38-,39-,40-,41-,42-,43-,44-,45-,46-,47-,48-,49-,50-,51-,52-,53+,54+,55+,56+,57+,58+,59+,60-,61-,62+,63+,64+,65+,66-,67+,68-,69+,70-,71-/m1/s1
constant: false
name: (alpha-D-Mannosyl)4-beta-D-mannosyl-diacetylchitobiosyldiphosphodolichol, human uterine homolog
initial amount: NaN
initial concentration: 1.0
type: Species
has only substance units: false
is: SBO:0000247
is: CHEBI:37633

metaR DMHPTCRNt
reversible: true
is described by: ECO:0000000
type: Reaction
fast: false
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 1 AUTHORS: NOTES:dmhptcoa is 'special' because its biochemical fat isn't known NJ
reactant: MODEL1310110042#
product: MODEL1310110042#
name: 2,6 dimethylheptanoyl crn transport
kinetic law: MODEL1310110042#

metaR CSNATr
reversible: true
reactant: MODEL1310110042#
type: Reaction
product: MODEL1310110042#
name: carnitine O-acetyltransferase
is: SBO:0000176
kinetic law: MODEL1310110042#
fast: false
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.7 Confidence Level: 4 AUTHORS: PMID:11257506,PMID:7829107 NOTES:IF

metaR TCHOLAte
type: Reaction
fast: false
name: bile acid intracellular transport
reversible: true
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:unknown mechanism, however bile acids need to be secreted out of the cell NJ
is described by: ECO:0000000
reactant: MODEL1310110042#
product: MODEL1310110042#
kinetic law: MODEL1310110042#

metaR RE1532M
kinetic law: MODEL1310110042#
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/4.2.1.17
reversible: true
reactant: MODEL1310110042#
product: MODEL1310110042#
fast: false
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.3.1.16
notes: GENE_ASSOCIATION: (10449.1) or (3032.1) or (3030.1) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.16 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:7775433,PMID:7923814,PMID:9568246,PMID:9920399 NOTES:
modifier: MODEL1310110042#
name: RE1532
type: Reaction

metaR SUCCt4 2
is: SBO:0000185
fast: false
reactant: MODEL1310110042#
type: Reaction
name: succinate transport via sodium symport
reversible: true
modifier: MODEL1310110042#
notes: GENE_ASSOCIATION: (9058.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:8946005,PMID:8967342 NOTES:NCD
kinetic law: MODEL1310110042#
is described by: ECO:0000269
product: MODEL1310110042#

metaM adp c
has only substance units: false
initial concentration: 1.0
boundary condition: false
is: CHEBI:16761
constant: false
is: http://identifiers.org/pubchem.compound/3310
is: C00008
initial amount: NaN
type: Species
is: HMDB01341
name: ADP
is: SBO:0000247

metaR r0596
modifier: MODEL1310110042#
notes: GENE_ASSOCIATION: (6576.1) SUBSYSTEM: CoA synthesis EC Number: 3.1.2.4 Confidence Level: 0 AUTHORS: PMID:10989434,PMID:8188708,PMID:8824301 NOTES:
fast: false
kinetic law: MODEL1310110042#
product: MODEL1310110042#
type: Reaction
name: 3-hydroxyisobutyryl-CoA hydrolase beta-Alanine metabolism / Propanoate metabolism EC:3.1.2.4
is: SBO:0000176
reactant: MODEL1310110042#
is described by: ECO:0000000
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110042#_be7a0055_fef6_4ff1_9eba_73389686e37b
boundary condition: true
type: Species
constant: false
initial concentration: NaN
is: Q8TCT1
name: PHOSPHO1
initial amount: NaN
is encoded by: hsa:162466
has only substance units: false
is: SBO:0000252

metaR UGCG
reactant: MODEL1310110042#
reversible: false
kinetic law: MODEL1310110042#
modifier: MODEL1310110042#
is described by: ECO:0000000
type: Reaction
is: SBO:0000176
name: Ceramide glucosyltransferase
product: MODEL1310110042#
is version of: http://identifiers.org/ec-code/2.4.1.80
notes: GENE_ASSOCIATION: (7357.1) SUBSYSTEM: Sphingolipid metabolism EC Number: 2.4.1.80 Confidence Level: 4 AUTHORS: PMID:8643456 NOTES:NJ
fast: false

metaR r2125
type: Reaction
reversible: true
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
is described by: ECO:0000000
fast: false
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
reactant: MODEL1310110042#
modifier: MODEL1310110042#
kinetic law: MODEL1310110042#
is: SBO:0000185
product: MODEL1310110042#

metaR r1262
kinetic law: MODEL1310110042#
product: MODEL1310110042#
name: EC:6.2.1.3
reversible: false
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 0 AUTHORS: PMID:8584017 NOTES:
fast: false
is: SBO:0000176
reactant: MODEL1310110042#
is described by: ECO:0000000

metaM 5adtststerones e
boundary condition: false
name: 5alpha-Dihydrotestosterone sulfate
has only substance units: false
constant: false
initial concentration: 1.0
type: Species
initial amount: NaN
notes: FORMULA: C19H29O5S CHARGE: -1 INCHI: InChI=1/C19H30O5S/c1-18-9-7-13(20)11-12(18)3-4-14-15-5-6-17(24-25(21,22)23)19(15,2)10-8-16(14)18/h12,14-17H,3-11H2,1-2H3,(H,21,22,23)/t12-,14-,15-,16-,17-,18-,19-/m0/s1 EHMN_ABBREVIATION: CE6032
is: HMDB06278
is: SBO:0000247

metaM mn l
has only substance units: false
boundary condition: false
constant: false
type: Species
initial amount: NaN
notes: FORMULA: C14H25NO11 CHARGE: 0 INCHI: InChI=1/C14H25NO11/c1-4(18)15-7-9(20)12(6(3-17)24-13(7)23)26-14-11(22)10(21)8(19)5(2-16)25-14/h5-14,16-17,19-23H,2-3H2,1H3,(H,15,18)/t5-,6-,7-,8-,9-,10+,11+,12-,13-,14-/m1/s1
is: SBO:0000247
is: HMDB06535
initial concentration: 1.0
name: beta-1,4-mannose-N-acetylglucosamine

http://identifiers.org/biomodels.db/MODEL1310110042#_ff5eeba1_8f64_4210_b648_e3f363000e77
constant: false
is encoded by: hsa:37
has only substance units: false
name: ACADVL
initial amount: NaN
is: SBO:0000252
is: P49748
type: Species
boundary condition: true
initial concentration: NaN

metaR EX pglyc hs LPAREN e RPAREN
kinetic law: MODEL1310110042#
reactant: MODEL1310110042#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: phosphatidylglycerol (homo sapiens) exchange
type: Reaction

metaM lnlccoa m
is: SBO:0000247
is: HMDB01064
notes: FORMULA: C39H62N7O17P3S CHARGE: -4 INCHI: InChI=1/C39H66N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-30(48)67-23-22-41-29(47)20-21-42-37(51)34(50)39(2,3)25-60-66(57,58)63-65(55,56)59-24-28-33(62-64(52,53)54)32(49)38(61-28)46-27-45-31-35(40)43-26-44-36(31)46/h8-9,11-12,26-28,32-34,38,49-50H,4-7,10,13-25H2,1-3H3,(H,41,47)(H,42,51)(H,55,56)(H,57,58)(H2,40,43,44)(H2,52,53,54)/b9-8+,12-11+ HEPATONET_1.0_ABBREVIATION: HC01983
is: http://identifiers.org/pubchem.compound/5462164
type: Species
constant: false
initial concentration: 1.0
has only substance units: false
initial amount: NaN
name: linoleic coenzyme A
boundary condition: false

metaM CE5116 x
initial concentration: 1.0
constant: false
type: Species
initial amount: NaN
is: CHEBI:57923
boundary condition: false
is: SBO:0000247
has only substance units: false
name: trans-3-cis-8,11,14-eicosatetraenoyl-CoA
notes: FORMULA: C41H62N7O17P3S CHARGE: -4 INCHI: InChI=1/C41H66N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-32(50)69-25-24-43-31(49)22-23-44-39(53)36(52)41(2,3)27-62-68(59,60)65-67(57,58)61-26-30-35(64-66(54,55)56)34(51)40(63-30)48-29-47-33-37(42)45-28-46-38(33)48/h8-9,11-12,14-15,19-20,28-30,34-36,40,51-52H,4-7,10,13,16-18,21-27H2,1-3H3,(H,43,49)(H,44,53)(H,57,58)(H,59,60)(H2,42,45,46)(H2,54,55,56)/p-4/b9-8-,12-11-,15-14-,20-19+/t30-,34+,35+,36u,40-/m0/s1 EHMN_ABBREVIATION: CE5116

metaR r0483
reactant: MODEL1310110042#
product: MODEL1310110042#
notes: GENE_ASSOCIATION: SUBSYSTEM: Pyrimidine catabolism EC Number: 2.6.1.22 Confidence Level: 0 AUTHORS: PMID:5773299 NOTES:
type: Reaction
is: SBO:0000176
is described by: ECO:0000000
name: (R)-3-Amino-2-methylpropanoate:2-oxoglutarate aminotransferase EC:2.6.1.22
reversible: true
fast: false
kinetic law: MODEL1310110042#

metaM pheme m
notes: FORMULA: C34H30FeN4O4 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00041 EHMN_ABBREVIATION: C00032
initial concentration: 1.0
boundary condition: false
has only substance units: false
is: SBO:0000247
is: C00032
is: CHEBI:17627
initial amount: NaN
is: HMDB03178
name: Protoheme
type: Species
constant: false

metaR S6T10g
is described by: ECO:0000000
reactant: MODEL1310110042#
modifier: MODEL1310110042#
type: Reaction
reversible: false
name: galactose/N-acetylglucosamine 6-O-sulfotransferase, Golgi apparatus
fast: false
notes: GENE_ASSOCIATION: (23563.2) or (9435.1) or (23563.1) or (10164.1) or (4166.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: Confidence Level: 4 AUTHORS: PMID:10330415,PMID:10491328,PMID:10913333,PMID:11278593,PMID:12403612,PMID:12855678,PMID:9722682 NOTES:NCD
product: MODEL1310110042#
kinetic law: MODEL1310110042#
is: SBO:0000176

metaM ksi pre14 g
boundary condition: false
has only substance units: false
is: CHEBI:28067
name: keratan sulfate I biosynthesis, precursor 14
constant: false
type: Species
initial amount: NaN
notes: FORMULA: C143H230N10O114S4X CHARGE: -5
initial concentration: 1.0
is: SBO:0000247

metaR RE0383C
kinetic law: MODEL1310110042#
notes: GENE_ASSOCIATION: (10327.1) SUBSYSTEM: Miscellaneous EC Number: 1.1.1.2 Confidence Level: 0 AUTHORS: PMID:1748675 NOTES:
is version of: http://identifiers.org/ec-code/1.1.1.2
fast: false
name: RE0383
reactant: MODEL1310110042#
product: MODEL1310110042#
is: SBO:0000176
modifier: MODEL1310110042#
is described by: ECO:0000000
type: Reaction
reversible: true

metaR PCt
is described by: ECO:0000269
kinetic law: MODEL1310110042#
modifier: MODEL1310110042#
is version of: http://identifiers.org/ec-code/3.6.3.44
is: SBO:0000185
fast: false
notes: GENE_ASSOCIATION: (5244.1) or (5244.3) or (5244.2) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:11826283,PMID:7912658 NOTES:for PC secretion into bile NJ
product: MODEL1310110042#
reversible: true
reactant: MODEL1310110042#
type: Reaction
name: phosphatidylcholine transporter

metaR r2126
fast: false
reactant: MODEL1310110042#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
modifier: MODEL1310110042#
type: Reaction
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
is: SBO:0000185
is described by: ECO:0000000
reversible: true
kinetic law: MODEL1310110042#
product: MODEL1310110042#

http://identifiers.org/biomodels.db/MODEL1310110042#_c10c5bfa_eab7_413a_a4d0_d53463fac893
boundary condition: true
is: SBO:0000252
initial concentration: NaN
has only substance units: false
is encoded by: hsa:27430
constant: false
initial amount: NaN
type: Species
name: MAT2B

metaM arachdcoa c
name: arachidonoyl-CoA(4-)
is: SBO:0000247
has only substance units: false
constant: false
type: Species
notes: FORMULA: C41H62N7O17P3S CHARGE: -4 INCHI: InChI=1S/C41H66N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-32(50)69-25-24-43-31(49)22-23-44-39(53)36(52)41(2,3)27-62-68(59,60)65-67(57,58)61-26-30-35(64-66(54,55)56)34(51)40(63-30)48-29-47-33-37(42)45-28-46-38(33)48/h8-9,11-12,14-15,17-18,28-30,34-36,40,51-52H,4-7,10,13,16,19-27H2,1-3H3,(H,43,49)(H,44,53)(H,57,58)(H,59,60)(H2,42,45,46)(H2,54,55,56)/p-4/b9-8-,12-11-,15-14-,18-17-/t30-,34-,35-,36+,40-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01986 EHMN_ABBREVIATION: C02249
initial amount: NaN
initial concentration: 1.0
boundary condition: false
is: HMDB06523
is: CHEBI:57368

metaR GULLACter
reactant: MODEL1310110042#
fast: false
name: gulonolactone endoplasmic reticular transport
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: PMID:11458272 NOTES:NCD
reversible: false
is described by: ECO:0000000
is: SBO:0000185
kinetic law: MODEL1310110042#
product: MODEL1310110042#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110042#_7ecee2ef_1c97_457a_b1f2_5d2a705d4618
initial concentration: NaN
is: Q9GZX3
type: Species
has only substance units: false
boundary condition: true
name: CHST6
constant: false
is: SBO:0000252
is encoded by: hsa:4166
initial amount: NaN

metaR r1435
reversible: false
fast: false
kinetic law: MODEL1310110042#
type: Reaction
reactant: MODEL1310110042#
name: Transport reaction
is described by: ECO:0000000
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:12930836,PMID:16288981,PMID:911815 NOTES:
product: MODEL1310110042#

metaM 2amac c
is: HMDB03609
boundary condition: false
type: Species
name: 2-aminoacrylic acid
notes: FORMULA: C3H5NO2 CHARGE: 0 INCHI: InChI=1S/C3H5NO2/c1-2(4)3(5)6/h1,4H2,(H,5,6) HEPATONET_1.0_ABBREVIATION: HC00906 EHMN_ABBREVIATION: C02218
has only substance units: false
is: CHEBI:17123
is: SBO:0000247
initial amount: NaN
constant: false
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110042#_c11c21ed_b009_4fcc_9715_f33faa8a640a
type: Species
boundary condition: true
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:25769
name: SLC24A2
has only substance units: false
initial amount: NaN
is: Q9UI40
constant: false

metaR MI134PP
kinetic law: MODEL1310110042#
modifier: MODEL1310110042#
product: MODEL1310110042#
is version of: http://identifiers.org/ec-code/3.1.3.57
reactant: MODEL1310110042#
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (3628.1) SUBSYSTEM: Inositol phosphate metabolism EC Number: 3.1.3.61 Confidence Level: 4 AUTHORS: PMID:2906139,PMID:8390685 NOTES:NCD
reversible: false
name: inositol-1,3,4-trisphosphate 1-phosphatase
type: Reaction
fast: false
is: SBO:0000176

metaM spmd c
is: HMDB01257
type: Species
initial amount: NaN
has only substance units: false
is: SBO:0000247
notes: FORMULA: C7H22N3 CHARGE: 3 HEPATONET_1.0_ABBREVIATION: HC00269 EHMN_ABBREVIATION: C00315
constant: false
boundary condition: false
is: C00315
is: CHEBI:57834
name: Spermidine
initial concentration: 1.0

metaR CSNATp
reversible: true
product: MODEL1310110042#
kinetic law: MODEL1310110042#
reactant: MODEL1310110042#
type: Reaction
notes: GENE_ASSOCIATION: (1384.2) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.7 Confidence Level: 2 AUTHORS: PMID:7829107 NOTES:NCD
is: SBO:0000176
is described by: ECO:0000304
fast: false
modifier: MODEL1310110042#
is version of: http://identifiers.org/ec-code/2.3.1.7
name: carnitine O-acetyltransferase, reverse direction, peroxisomal

http://identifiers.org/biomodels.db/MODEL1310110042#_b351ea53_d71e_4030_8448_6211c3198e41
has only substance units: false
is: Q9H0P0
initial concentration: NaN
is encoded by: hsa:51251
type: Species
name: NT5C3
is: SBO:0000252
boundary condition: true
constant: false
initial amount: NaN

metaR TETTET6COAtx
fast: false
is described by: ECO:0000000
type: Reaction
is: SBO:0000185
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: NOTES:interaction between peroxisomes and ER (some enzymes on the outer membrane) NJ
name: fatty acid intracellular transport
kinetic law: MODEL1310110042#
reactant: MODEL1310110042#
product: MODEL1310110042#

metaM ksi deg22 l
is: HMDB00812
type: Species
is: SBO:0000247
constant: false
initial concentration: 1.0
name: keratan sulfate I, degradation product 22
notes: FORMULA: C132H214N9O111S5 CHARGE: -5
initial amount: NaN
boundary condition: false
is: CHEBI:16953
has only substance units: false

metaM spmd e
initial amount: NaN
has only substance units: false
is: HMDB01257
is: CHEBI:57834
notes: FORMULA: C7H22N3 CHARGE: 3 HEPATONET_1.0_ABBREVIATION: HC00269 EHMN_ABBREVIATION: C00315
name: Spermidine
is: C00315
initial concentration: 1.0
type: Species
constant: false
is: SBO:0000247
boundary condition: false

metaR ASCBt4
notes: GENE_ASSOCIATION: (9962.2) or (9963.1) or (9962.1) or (9963.2) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10471399,PMID:10556483,PMID:10556521,PMID:10631088,PMID:15705056 NOTES:NCD
reversible: true
name: L-ascorbate transport via proton symport
modifier: MODEL1310110042#
is described by: ECO:0000269
reactant: MODEL1310110042#
is: SBO:0000185
type: Reaction
fast: false
kinetic law: MODEL1310110042#
product: MODEL1310110042#

http://identifiers.org/biomodels.db/MODEL1310110042#_822c1d9a_96c6_4634_95f0_4b99d93ec1bb
is encoded by: hsa:23057
initial amount: NaN
is: SBO:0000252
type: Species
boundary condition: true
is: Q9BZQ4
constant: false
initial concentration: NaN
has only substance units: false
name: NMNAT2

metaR r2127
type: Reaction
kinetic law: MODEL1310110042#
product: MODEL1310110042#
is described by: ECO:0000000
reversible: true
fast: false
reactant: MODEL1310110042#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
is: SBO:0000185
modifier: MODEL1310110042#

metaM HC01415 m
initial concentration: 1.0
is: CHEBI:27537
type: Species
notes: FORMULA: C29H44N7O17P3S CHARGE: -4 INCHI: InChI=1S/C29H48N7O17P3S/c1-4-5-6-7-8-9-20(38)57-13-12-31-19(37)10-11-32-27(41)24(40)29(2,3)15-50-56(47,48)53-55(45,46)49-14-18-23(52-54(42,43)44)22(39)28(51-18)36-17-35-21-25(30)33-16-34-26(21)36/h8-9,16-18,22-24,28,39-40H,4-7,10-15H2,1-3H3,(H,31,37)(H,32,41)(H,45,46)(H,47,48)(H2,30,33,34)(H2,42,43,44)/b9-8+/t18-,22-,23-,24+,28-/m1/s1 EHMN_ABBREVIATION: C05276
name: (2E)-Octenoyl-CoA
initial amount: NaN
is: SBO:0000247
has only substance units: false
boundary condition: false
constant: false

metaM dcdp n
is: SBO:0000247
boundary condition: false
notes: FORMULA: C9H12N3O10P2 CHARGE: -3 INCHI: InChI=1S/C9H15N3O10P2/c10-7-1-2-12(9(14)11-7)8-3-5(13)6(21-8)4-20-24(18,19)22-23(15,16)17/h1-2,5-6,8,13H,3-4H2,(H,18,19)(H2,10,11,14)(H2,15,16,17)/p-3/t5-,6+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00506 EHMN_ABBREVIATION: C00705
constant: false
is: HMDB01245
initial amount: NaN
initial concentration: 1.0
is: CHEBI:58593
has only substance units: false
name: dCDP(3-)
type: Species

metaM hdcea r
has only substance units: false
type: Species
initial concentration: 1.0
constant: false
is: CHEBI:32372
is: SBO:0000247
is: HMDB03229
name: palmitoleate
boundary condition: false
initial amount: NaN
notes: FORMULA: C16H29O2 CHARGE: -1 INCHI: InChI=1S/C16H30O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16(17)18/h7-8H,2-6,9-15H2,1H3,(H,17,18)/p-1/b8-7- HEPATONET_1.0_ABBREVIATION: HC01981 EHMN_ABBREVIATION: CE0850

metaM gthox m
initial concentration: 1.0
is: SBO:0000247
type: Species
initial amount: NaN
has only substance units: false
boundary condition: false
constant: false
is: HMDB03337
is: CHEBI:58297
notes: FORMULA: C20H30N6O12S2 CHARGE: -2 INCHI: InChI=1S/C20H32N6O12S2/c21-9(19(35)36)1-3-13(27)25-11(17(33)23-5-15(29)30)7-39-40-8-12(18(34)24-6-16(31)32)26-14(28)4-2-10(22)20(37)38/h9-12H,1-8,21-22H2,(H,23,33)(H,24,34)(H,25,27)(H,26,28)(H,29,30)(H,31,32)(H,35,36)(H,37,38)/p-2/t9-,10-,11-,12-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00125 EHMN_ABBREVIATION: C00127

metaM dcdp m
is: HMDB01245
boundary condition: false
notes: FORMULA: C9H12N3O10P2 CHARGE: -3 INCHI: InChI=1S/C9H15N3O10P2/c10-7-1-2-12(9(14)11-7)8-3-5(13)6(21-8)4-20-24(18,19)22-23(15,16)17/h1-2,5-6,8,13H,3-4H2,(H,18,19)(H2,10,11,14)(H2,15,16,17)/p-3/t5-,6+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00506 EHMN_ABBREVIATION: C00705
initial amount: NaN
has only substance units: false
constant: false
name: dCDP(3-)
initial concentration: 1.0
type: Species
is: SBO:0000247
is: CHEBI:58593

metaM glyc R c
name: D-glycerate
is: HMDB00139
is: SBO:0000247
initial amount: NaN
initial concentration: 1.0
constant: false
is: CHEBI:16659
type: Species
has only substance units: false
notes: FORMULA: C3H5O4 CHARGE: -1 INCHI: InChI=1S/C3H6O4/c4-1-2(5)3(6)7/h2,4-5H,1H2,(H,6,7)/p-1/t2-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00235
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110042#_d8416eaf_360a_4444_b7a4_74318183b41c
is encoded by: hsa:3612
is: SBO:0000252
initial concentration: NaN
is: B7Z6Q4
constant: false
initial amount: NaN
type: Species
has only substance units: false
name: IMPA1
boundary condition: true

metaR H7ET2er
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.7.8.1
type: Reaction
reversible: false
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (5281.1) and (54872.1) or (5281.2) and (54872.1) SUBSYSTEM: Phosphatidylinositol phosphate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:15632136 NOTES:NCD
fast: false
name: H7 phosphoethanolaminyl transferase, endoplasmic reticulum
modifier: MODEL1310110042#
kinetic law: MODEL1310110042#
product: MODEL1310110042#
reactant: MODEL1310110042#

http://identifiers.org/biomodels.db/MODEL1310110042#_d3408619_fb29_42fb_a696_f71ee75b0a54
is encoded by: hsa:501
type: Species
has only substance units: false
is: E7EPT3
name: ALDH7A1
boundary condition: true
initial amount: NaN
initial concentration: NaN
is: SBO:0000252
constant: false

http://identifiers.org/biomodels.db/MODEL1310110042#_2159af11_db3e_4c7f_84f1_04157000b4cc
name: ALDOA
is encoded by: hsa:226
type: Species
initial concentration: NaN
initial amount: NaN
constant: false
is: SBO:0000252
has only substance units: false
boundary condition: true

metaR PIPLC
is described by: ECO:0000000
is: SBO:0000176
notes: GENE_ASSOCIATION: (23236.2) or (5336.1) or (23007.1) or (113026.1) or (89869.1) or (84812.1) or (9651.1) or (5335.1) or (51196.1) or (257068.1) or (5332.2) or (5331.1) or (5335.2) or (5334.1) or (5332.1) or (5330.1) or (23236.1) or (5333.1) SUBSYSTEM: Inositol phosphate metabolism EC Number: 3.1.4.3 Confidence Level: 4 AUTHORS: PMID:10702670,PMID:10702683,PMID:10760467,PMID:11022047,PMID:11022048,PMID:11118617,PMID:12117804,PMID:12213492,PMID:12416999,PMID:13333955,PMID:15140260,PMID:1644792,PMID:2167438,PMID:7607669,PMID:7612006,PMID:7633416,PMID:7789993,PMID:7835906,PMID:7849701,PMID:7890667,PMID:8530101,PMID:9345909 NOTES:NCD
modifier: MODEL1310110042#
reactant: MODEL1310110042#
name: phosphatidylinositol phospholipase C
reversible: false
is version of: http://identifiers.org/ec-code/3.1.4.11
product: MODEL1310110042#
kinetic law: MODEL1310110042#
type: Reaction
fast: false

http://identifiers.org/biomodels.db/MODEL1310110042#_c8d075c3_51a6_4c3c_b98f_bd431476136f
name: _R33828_1_c
constant: false
initial concentration: NaN
is encoded by: hsa:R33828
type: Species
has only substance units: false
boundary condition: true
initial amount: NaN
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110042#_1a5eb9ab_fa09_4971_af27_5faca0d142c5
boundary condition: true
is: SBO:0000252
has only substance units: false
is: Q308M7
initial amount: NaN
name: ENPP3
type: Species
constant: false
initial concentration: NaN
is encoded by: hsa:5169

metaR NMNATr
product: MODEL1310110042#
reversible: true
fast: false
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/2.7.7.1
kinetic law: MODEL1310110042#
is: SBO:0000176
modifier: MODEL1310110042#
name: nicotinamide-nucleotide adenylyltransferase
type: Reaction
notes: GENE_ASSOCIATION: (349565.1) or (23057.1) or (23057.2) SUBSYSTEM: NAD metabolism EC Number: Confidence Level: 4 AUTHORS: NOTES:
reactant: MODEL1310110042#

metaM biocyt m
is: HMDB03134
has only substance units: false
initial amount: NaN
constant: false
is: SBO:0000247
boundary condition: false
name: Biocytin
is: http://identifiers.org/pubchem.compound/7886
type: Species
initial concentration: 1.0
is: C05552
notes: FORMULA: C16H28N4O4S CHARGE: 0 INCHI: InChI=1/C16H28N4O4S/c17-10(15(22)23)5-3-4-8-18-13(21)7-2-1-6-12-14-11(9-25-12)19-16(24)20-14/h10-12,14H,1-9,17H2,(H,18,21)(H,22,23)(H2,19,20,24)/t10-,11-,12-,14-/m0/s1 EHMN_ABBREVIATION: C05552

metaM pac c
notes: FORMULA: C8H7O2 CHARGE: -1 INCHI: InChI=1S/C8H8O2/c9-8(10)6-7-4-2-1-3-5-7/h1-5H,6H2,(H,9,10)/p-1 HEPATONET_1.0_ABBREVIATION: HC01781 EHMN_ABBREVIATION: C07086
type: Species
initial concentration: 1.0
has only substance units: false
boundary condition: false
constant: false
is: HMDB00209
initial amount: NaN
is: SBO:0000247
is: CHEBI:18401
name: phenylacetate

http://identifiers.org/biomodels.db/MODEL1310110042#_2772b01e_e5fb_42ad_bdad_b5441d8c3a22
initial concentration: NaN
is: SBO:0000252
boundary condition: true
has only substance units: false
is encoded by: hsa:6487
type: Species
name: ST3GAL3
constant: false
initial amount: NaN

metaR r1546
reactant: MODEL1310110042#
is described by: ECO:0000000
is: SBO:0000185
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
fast: false
product: MODEL1310110042#
reversible: true
kinetic law: MODEL1310110042#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:

metaM pheme c
is: SBO:0000247
initial amount: NaN
notes: FORMULA: C34H30FeN4O4 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00041 EHMN_ABBREVIATION: C00032
initial concentration: 1.0
constant: false
name: Protoheme
type: Species
has only substance units: false
is: HMDB03178
boundary condition: false
is: C00032
is: CHEBI:17627

http://identifiers.org/biomodels.db/MODEL1310110042#_d91cd676_6771_4ee3_b8bf_1336578f971c
constant: false
has only substance units: false
type: Species
initial amount: NaN
boundary condition: true
is: Q96HD9
initial concentration: NaN
name: ACY3
is: SBO:0000252
is encoded by: hsa:91703

metaM arachdcoa m
type: Species
constant: false
initial concentration: 1.0
has only substance units: false
is: HMDB06523
name: arachidonoyl-CoA(4-)
is: CHEBI:57368
notes: FORMULA: C41H62N7O17P3S CHARGE: -4 INCHI: InChI=1S/C41H66N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-32(50)69-25-24-43-31(49)22-23-44-39(53)36(52)41(2,3)27-62-68(59,60)65-67(57,58)61-26-30-35(64-66(54,55)56)34(51)40(63-30)48-29-47-33-37(42)45-28-46-38(33)48/h8-9,11-12,14-15,17-18,28-30,34-36,40,51-52H,4-7,10,13,16,19-27H2,1-3H3,(H,43,49)(H,44,53)(H,57,58)(H,59,60)(H2,42,45,46)(H2,54,55,56)/p-4/b9-8-,12-11-,15-14-,18-17-/t30-,34-,35-,36+,40-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01986 EHMN_ABBREVIATION: C02249
is: SBO:0000247
boundary condition: false
initial amount: NaN

metaR r0488
kinetic law: MODEL1310110042#
fast: false
product: MODEL1310110042#
reversible: true
reactant: MODEL1310110042#
type: Reaction
name: (R)-Mevalonate:NADP+ oxidoreductase (CoA acylating) Biosynthesis of steroids EC:1.1.1.34
notes: GENE_ASSOCIATION: SUBSYSTEM: Cholesterol metabolism EC Number: 1.1.1.34 Confidence Level: 0 AUTHORS: PMID:10698924,PMID:11108725,PMID:12454262,PMID:3745272,PMID:3883347 NOTES:
is: SBO:0000176
is described by: ECO:0000000

metaR NACASPtm
fast: false
name: N-acetyl-L-aspartate transport (mitochondria to cytosol)
reactant: MODEL1310110042#
product: MODEL1310110042#
kinetic law: MODEL1310110042#
type: Reaction
is: SBO:0000185
reversible: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: PMID:11279290 NOTES:MM
is described by: ECO:0000000

metaM 2mp2coa m
initial concentration: 1.0
constant: false
initial amount: NaN
is: SBO:0000247
boundary condition: false
is: HMDB01011
notes: FORMULA: C25H36N7O17P3S CHARGE: -4 INCHI: InChI=1S/C25H40N7O17P3S/c1-13(2)24(37)53-8-7-27-15(33)5-6-28-22(36)19(35)25(3,4)10-46-52(43,44)49-51(41,42)45-9-14-18(48-50(38,39)40)17(34)23(47-14)32-12-31-16-20(26)29-11-30-21(16)32/h11-12,14,17-19,23,34-35H,1,5-10H2,2-4H3,(H,27,33)(H,28,36)(H,41,42)(H,43,44)(H2,26,29,30)(H2,38,39,40)/t14-,17-,18-,19+,23-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01122 EHMN_ABBREVIATION: C03460
is: CHEBI:27754
has only substance units: false
name: 2-Methylprop-2-enoyl-CoA
type: Species

metaM HC00591 m
notes: FORMULA: C5H6NO4 CHARGE: -1 INCHI: InChI=1S/C5H7NO4/c6-4(8)2-1-3(7)5(9)10/h1-2H2,(H2,6,8)(H,9,10)/p-1 EHMN_ABBREVIATION: C00940
boundary condition: false
name: 2-oxoglutaramate
initial concentration: 1.0
has only substance units: false
constant: false
is: CHEBI:16769
type: Species
initial amount: NaN
is: SBO:0000247

metaR EX taur LPAREN e RPAREN
kinetic law: MODEL1310110042#
reactant: MODEL1310110042#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Taurine exchange
type: Reaction

metaM hpdca c
is: SBO:0000247
boundary condition: false
initial concentration: 1.0
constant: false
has only substance units: false
initial amount: NaN
type: Species
name: margarate
notes: FORMULA: C17H33O2 CHARGE: -1 INCHI: InChI=1S/C17H34O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17(18)19/h2-16H2,1H3,(H,18,19)/p-1
is: HMDB02259
is: CHEBI:32366

http://identifiers.org/biomodels.db/MODEL1310110042#_4a3155bb_8623_43d8_87e4_cbf2bc3870bc
is: SBO:0000252
boundary condition: true
initial amount: NaN
is encoded by: hsa:10678
initial concentration: NaN
constant: false
has only substance units: false
name: B3GNT2
is: Q9NY97
type: Species

metaM m7mpdol L r
constant: false
is: SBO:0000247
name: (alpha-D-Mannosyl)7-beta-D-mannosyl-diacetylchitobiosyldiphosphodolichol, human liver homolog
has only substance units: false
type: Species
boundary condition: false
initial concentration: 1.0
is: CHEBI:37636
notes: FORMULA: C1720H2828N20O570P20 CHARGE: -20
initial amount: NaN

metaM HC00460 c
name: 2,5-dihydroxybenzoate
boundary condition: false
is: CHEBI:58044
has only substance units: false
notes: FORMULA: C7H5O4 CHARGE: -1 INCHI: InChI=1S/C7H6O4/c8-4-1-2-6(9)5(3-4)7(10)11/h1-3,8-9H,(H,10,11)/p-1 EHMN_ABBREVIATION: C00628
initial concentration: 1.0
is: SBO:0000247
constant: false
initial amount: NaN
type: Species

metaR LYStiDF
name: L-lysine transport via diffusion (extracellular to cytosol)
fast: false
kinetic law: MODEL1310110042#
modifier: MODEL1310110042#
reactant: MODEL1310110042#
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (6541.1) or (6542.1) or (55089.1) or (84889.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:11342143,PMID:11414754,PMID:11591158,PMID:11891586,PMID:12049641,PMID:1348489,PMID:14770310,PMID:7534987,PMID:8954799 NOTES:SAB
type: Reaction
product: MODEL1310110042#
is: SBO:0000185
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110042#_f411d865_8ee5_477c_95b8_c0a249b04dbf
has only substance units: false
is: SBO:0000252
is encoded by: hsa:2629
initial amount: NaN
name: GBA
initial concentration: NaN
boundary condition: true
is: P04062
type: Species
constant: false

metaR TRIODTHYt2
product: MODEL1310110042#
fast: false
kinetic law: MODEL1310110042#
is: SBO:0000185
modifier: MODEL1310110042#
name: T3 transport via facilitated diffusion
type: Reaction
notes: GENE_ASSOCIATION: (6567.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12871948,PMID:7981683 NOTES:NJ
reversible: true
reactant: MODEL1310110042#
is described by: ECO:0000269

metaR r1547
fast: false
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
product: MODEL1310110042#
is described by: ECO:0000000
kinetic law: MODEL1310110042#
reversible: true
reactant: MODEL1310110042#
is: SBO:0000185
type: Reaction

metaR MACACI
modifier: MODEL1310110042#
is version of: http://identifiers.org/ec-code/2.5.1.18
kinetic law: MODEL1310110042#
is described by: ECO:0000269
is: SBO:0000176
reversible: false
type: Reaction
product: MODEL1310110042#
notes: GENE_ASSOCIATION: (2954.1) or (2954.3) or (2954.2) SUBSYSTEM: Tyrosine metabolism EC Number: 5.2.1.2 Confidence Level: 4 AUTHORS: PMID:10373324 NOTES:NCD
name: maleylacetoacetate isomerase
fast: false
reactant: MODEL1310110042#

metaR r1154
is described by: ECO:0000000
kinetic law: MODEL1310110042#
product: MODEL1310110042#
reactant: MODEL1310110042#
name: EC:1.2.7.2
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Propanoate metabolism EC Number: 1.2.7.2 Confidence Level: 0 AUTHORS: PMID:2649080,PMID:283398,PMID:3718468,PMID:9381974 NOTES:
fast: false
type: Reaction
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110042#_e42265fb_e328_4deb_8342_9417a5e00341
is encoded by: hsa:427
initial concentration: NaN
is: Q13510
initial amount: NaN
boundary condition: true
is: SBO:0000252
name: ASAH1
has only substance units: false
constant: false
type: Species

metaR r1544
type: Reaction
fast: false
kinetic law: MODEL1310110042#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is described by: ECO:0000000
product: MODEL1310110042#
is: SBO:0000185
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reversible: true
reactant: MODEL1310110042#

metaR PYDXDH
product: MODEL1310110042#
name: pyridoxal dehydrogenase
is version of: http://identifiers.org/ec-code/1.2.3.1
is described by: ECO:0000269
kinetic law: MODEL1310110042#
reversible: false
type: Reaction
is: SBO:0000176
reactant: MODEL1310110042#
notes: GENE_ASSOCIATION: (316.1) SUBSYSTEM: Vitamin B6 metabolism EC Number: 1.2.3.1 Confidence Level: 4 AUTHORS: PMID:6380540 NOTES:IT
modifier: MODEL1310110042#
fast: false

metaM dopasf c
is: CHEBI:37946
initial concentration: 1.0
is: SBO:0000247
initial amount: NaN
name: dopamine 3-O-sulfate
type: Species
constant: false
boundary condition: false
is: HMDB06275
has only substance units: false
notes: FORMULA: C8H11NO5S CHARGE: 0 INCHI: InChI=1S/C8H11NO5S/c9-4-3-6-1-2-7(10)8(5-6)14-15(11,12)13/h1-2,5,10H,3-4,9H2,(H,11,12,13) EHMN_ABBREVIATION: C13690

metaM apoC Lys btn m
notes: FORMULA: C16H27N4O3SX CHARGE: 0
name: Holocarboxylase (biotin covalent bound to Lys residue of apoC)
initial amount: NaN
constant: false
type: Species
has only substance units: false
is: HMDB03134
boundary condition: false
is: http://identifiers.org/pubchem.compound/7886
initial concentration: 1.0
is: SBO:0000247
is: C05552

metaM lnlncacoa c
boundary condition: false
notes: FORMULA: C39H60N7O17P3S CHARGE: -4 INCHI: InChI=1S/C39H64N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-30(48)67-23-22-41-29(47)20-21-42-37(51)34(50)39(2,3)25-60-66(57,58)63-65(55,56)59-24-28-33(62-64(52,53)54)32(49)38(61-28)46-27-45-31-35(40)43-26-44-36(31)46/h5-6,8-9,11-12,26-28,32-34,38,49-50H,4,7,10,13-25H2,1-3H3,(H,41,47)(H,42,51)(H,55,56)(H,57,58)(H2,40,43,44)(H2,52,53,54)/b6-5-,9-8-,12-11-/t28-,32-,33-,34+,38-/m1/s1 EHMN_ABBREVIATION: CE4809
is: HMDB06290
initial concentration: 1.0
constant: false
is: CHEBI:51985
initial amount: NaN
name: alpha-Linolenoyl-CoA
is: SBO:0000247
has only substance units: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110042#_774a1f09_773e_4623_a2fa_e60cc3f67d04
is: P57054
is encoded by: hsa:51227
is: SBO:0000252
boundary condition: true
constant: false
initial concentration: NaN
name: PIGP
type: Species
initial amount: NaN
has only substance units: false

metaM dag hs c
initial concentration: 1.0
is: CHEBI:18035
initial amount: NaN
constant: false
name: diglyceride
type: Species
boundary condition: false
notes: FORMULA: C3H6OFULLRCO2FULLR2CO2 CHARGE: 0
is: SBO:0000247
has only substance units: false

metaM adp m
is: C00008
type: Species
name: ADP
is: SBO:0000247
initial concentration: 1.0
initial amount: NaN
is: CHEBI:456216
boundary condition: false
constant: false
is: HMDB01341
has only substance units: false
is: http://identifiers.org/pubchem.compound/3310

metaR CMPSAS
type: Reaction
fast: false
product: MODEL1310110042#
reversible: false
kinetic law: MODEL1310110042#
notes: GENE_ASSOCIATION: (55907.1) SUBSYSTEM: Aminosugar metabolism EC Number: 2.7.7.43 Confidence Level: 2 AUTHORS: PMID:9689047 NOTES:NCD
name: CMP sialic acid synthase
is: SBO:0000176
reactant: MODEL1310110042#
modifier: MODEL1310110042#
is version of: http://identifiers.org/ec-code/2.7.7.43
is described by: ECO:0000304

metaR EX lnlc LPAREN e RPAREN
kinetic law: MODEL1310110042#
reactant: MODEL1310110042#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: linoleic acid (all cis C18:2) exchange
type: Reaction

metaR r1851
reversible: false
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
product: MODEL1310110042#
is: SBO:0000185
kinetic law: MODEL1310110042#
is described by: ECO:0000000
modifier: MODEL1310110042#
fast: false
type: Reaction
name: Y+LAT2 Utilized transport
reactant: MODEL1310110042#

metaM sebacid x
initial concentration: 1.0
initial amount: NaN
is: SBO:0000247
name: sebacicacid
boundary condition: false
constant: false
is: C08277
type: Species
is: HMDB00792
has only substance units: false
notes: FORMULA: C10H16O4 CHARGE: -2

metaM sphings l
is: SBO:0000247
is: CHEBI:57756
initial concentration: 1.0
has only substance units: false
name: sphingosine(1+)
type: Species
is: HMDB00252
constant: false
boundary condition: false
notes: FORMULA: C18H38NO2 CHARGE: 1 INCHI: InChI=1S/C18H37NO2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-18(21)17(19)16-20/h14-15,17-18,20-21H,2-13,16,19H2,1H3/p+1/b15-14+/t17-,18+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00271 EHMN_ABBREVIATION: C00319
initial amount: NaN

metaR r0594
notes: GENE_ASSOCIATION: (AA081045.1) or (AI620219.1) or (219.1) or (217.1) or (224.1) or (501.1) or (223.1) or (AU149534.1) or (T83654.1) SUBSYSTEM: Lysine metabolism EC Number: 1.2.1.31 Confidence Level: 0 AUTHORS: PMID:2160277 NOTES:
reversible: true
kinetic law: MODEL1310110042#
reactant: MODEL1310110042#
product: MODEL1310110042#
name: L-2-Aminoadipate-6-semialdehyde:NAD+ 6-oxidoreductase Lysine degradation EC:1.2.1.31
fast: false
type: Reaction
modifier: MODEL1310110042#
is: SBO:0000176
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/1.2.1.3

http://identifiers.org/biomodels.db/MODEL1310110042#_1805cb92_0b37_4b4f_aa8c_4c25902b0e46
type: Species
is encoded by: hsa:54344
initial amount: NaN
is: SBO:0000297
is encoded by: hsa:8818
name: DPM3:DPM1:DPM2
has only substance units: false
has part: Q9P2X0
initial concentration: NaN
boundary condition: true
constant: false

http://identifiers.org/biomodels.db/MODEL1310110042#_9caa1bf3_f38e_4095_a8c7_57adb8b3b141
has part: P56134
initial concentration: NaN
is: SBO:0000297
boundary condition: true
type: Species
constant: false
is encoded by: hsa:9551
has only substance units: false
initial amount: NaN
name: ATP5H:ATP5L:NSF:ATP5F1:ATP5G3:ATP5I:ATP5J:ATP5J2
is encoded by: hsa:522

metaM gluside hs g
is: CHEBI:18368
notes: FORMULA: C24H46NO7FULLRCO CHARGE: 0 EHMN_ABBREVIATION: C01190
has only substance units: false
initial concentration: 1.0
initial amount: NaN
is: SBO:0000247
constant: false
name: D-glucosyl-N-acylsphingosine
boundary condition: false
type: Species

metaM HC01610 e
is: CHEBI:28607
boundary condition: false
name: CoproporphyrinogenI
constant: false
is: SBO:0000247
has only substance units: false
type: Species
notes: FORMULA: C36H40N4O8 CHARGE: -4 INCHI: InChI=1S/C36H44N4O8/c1-17-21(5-9-33(41)42)29-14-26-19(3)23(7-11-35(45)46)31(39-26)16-28-20(4)24(8-12-36(47)48)32(40-28)15-27-18(2)22(6-10-34(43)44)30(38-27)13-25(17)37-29/h37-40H,5-16H2,1-4H3,(H,41,42)(H,43,44)(H,45,46)(H,47,48) EHMN_ABBREVIATION: C05768
initial amount: NaN
initial concentration: 1.0

metaR DURAD
is described by: ECO:0000269
kinetic law: MODEL1310110042#
name: dihydrouracil dehydrogenase (NADP)
is version of: http://identifiers.org/ec-code/1.3.1.2
reactant: MODEL1310110042#
notes: GENE_ASSOCIATION: (1806.1) SUBSYSTEM: Pyrimidine catabolism EC Number: 1.3.1.2 Confidence Level: 4 AUTHORS: PMID:1512248,PMID:8221682 NOTES:_01-26-05 IT based on Lu et al., JBC,1992,24,17102-17109
product: MODEL1310110042#
modifier: MODEL1310110042#
reversible: true
is: SBO:0000176
type: Reaction
fast: false

metaR BTNt4i
product: MODEL1310110042#
fast: false
name: Biotin uptake (antiport)
is: SBO:0000185
notes: GENE_ASSOCIATION: (80704.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14770311,PMID:15623830 NOTES:IT
reversible: false
reactant: MODEL1310110042#
kinetic law: MODEL1310110042#
is described by: ECO:0000269
type: Reaction
modifier: MODEL1310110042#

metaR THMPPtm
reversible: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:12014993 NOTES:IT
is described by: ECO:0000000
is: SBO:0000185
kinetic law: MODEL1310110042#
product: MODEL1310110042#
type: Reaction
reactant: MODEL1310110042#
name: Thiamine diphosphate transport in via anion antiport, mitochondria
fast: false

metaM CE5786 e
initial concentration: 1.0
is: CHEBI:27485
initial amount: NaN
boundary condition: false
has only substance units: false
is: HMDB02710
constant: false
notes: FORMULA: C56H87N17O11 CHARGE: 2 INCHI: InChI=1/C56H85N17O11/c1-6-32(4)45(57)52(81)66-33(5)46(75)67-38(15-10-22-63-55(58)59)47(76)68-39(16-11-23-64-56(60)61)48(77)71-42(28-36-29-62-30-65-36)53(82)73-24-12-17-44(73)51(80)70-41(27-35-18-20-37(74)21-19-35)49(78)69-40(26-34-13-8-7-9-14-34)50(79)72-43(54(83)84)25-31(2)3/h7-9,13-14,18-21,29-33,38-45,74H,6,10-12,15-17,22-28,57H2,1-5H3,(H,62,65)(H,66,81)(H,67,75)(H,68,76)(H,69,78)(H,70,80)(H,71,77)(H,72,79)(H,83,84)(H4,58,59,63)(H4,60,61,64)/p+2/t32-,33+,38-,39+,40-,41+,42-,43+,44-,45-/m1/s1 EHMN_ABBREVIATION: CE5786
name: kinetensin
is: SBO:0000247
type: Species

http://identifiers.org/biomodels.db/MODEL1310110042#_f64b58a6_e940_4c45_b676_c0f3b6fb2e77
name: SLC6A7
boundary condition: true
initial concentration: NaN
constant: false
is: Q99884
has only substance units: false
type: Species
initial amount: NaN
is: SBO:0000252
is encoded by: hsa:6534

http://identifiers.org/biomodels.db/MODEL1310110042#_36cc4951_0e9b_499f_8787_e93f311ff2ce
constant: false
initial concentration: NaN
is: SBO:0000252
has only substance units: false
initial amount: NaN
name: _AI926493_1_c
boundary condition: true
is encoded by: hsa:AI926493
type: Species

http://identifiers.org/biomodels.db/MODEL1310110042#_f6ba6a39_26c7_42e4_b925_e4081a34d54f
constant: false
is: SBO:0000252
initial amount: NaN
is: Q9P2X0
has only substance units: false
initial concentration: NaN
name: DPM3
is encoded by: hsa:54344
type: Species
boundary condition: true

metaM adp n
boundary condition: false
constant: false
notes: FORMULA: C10H12N5O10P2 CHARGE: -3 INCHI: InChI=1S/C10H15N5O10P2/c11-8-5-9(13-2-12-8)15(3-14-5)10-7(17)6(16)4(24-10)1-23-27(21,22)25-26(18,19)20/h2-4,6-7,10,16-17H,1H2,(H,21,22)(H2,11,12,13)(H2,18,19,20)/p-3/t4-,6-,7-,10-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00018 EHMN_ABBREVIATION: C00008
initial concentration: 1.0
initial amount: NaN
is: CHEBI:456216
name: ADP(3-)
type: Species
has only substance units: false
is: SBO:0000247
is: HMDB01341

http://identifiers.org/biomodels.db/MODEL1310110042#_25ca091b_ec49_43f1_a69f_41e35bc52069
name: LEFTY1
is encoded by: hsa:10637
initial concentration: NaN
type: Species
boundary condition: true
initial amount: NaN
constant: false
is: O75610
has only substance units: false
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110042#_e2ea1da1_a02c_406b_9083_676aa1c454ff
is encoded by: hsa:10317
is: SBO:0000252
type: Species
initial amount: NaN
constant: false
boundary condition: true
name: B3GALT5
has only substance units: false
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110042#_f24a194b_720a_4fc5_a04b_ac11f6b8edb1
type: Species
name: MTR
is: Q99707
initial concentration: NaN
is encoded by: hsa:4548
boundary condition: true
constant: false
has only substance units: false
is: SBO:0000252
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110042#_912f65d2_f98b_4b6c_a926_9eb579244c2d
initial concentration: NaN
name: MPST
boundary condition: true
is encoded by: hsa:4357
initial amount: NaN
has only substance units: false
type: Species
is: SBO:0000252
is: P25325
constant: false

metaR ALDD2y
is version of: http://identifiers.org/ec-code/1.2.1.5
is: SBO:0000176
product: MODEL1310110042#
fast: false
reactant: MODEL1310110042#
notes: GENE_ASSOCIATION: (223.1) or (221.1) or (218.1) or (8854.1) or (8854.3) or (222.1) or (8854.2) or (224.1) SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: 1.2.1.4 Confidence Level: 0 AUTHORS: PMID:12616643 NOTES:See also ALDH1 (1.2.1.3); r0177
type: Reaction
is version of: http://identifiers.org/ec-code/1.2.1.3
is described by: ECO:0000000
modifier: MODEL1310110042#
kinetic law: MODEL1310110042#
name: aldehyde dehydrogenase (acetaldehyde, NADP)
reversible: false
is version of: http://identifiers.org/ec-code/1.2.1.36

metaR MMEm
is: SBO:0000176
reversible: true
reactant: MODEL1310110042#
product: MODEL1310110042#
name: methylmalonyl-CoA epimerase/racemase
is described by: ECO:0000269
type: Reaction
modifier: MODEL1310110042#
notes: GENE_ASSOCIATION: (84693.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 5.1.99.1 Confidence Level: 4 AUTHORS: PMID:11481338 NOTES:TDV
kinetic law: MODEL1310110042#
is version of: http://identifiers.org/ec-code/5.1.99.1
fast: false

http://identifiers.org/biomodels.db/MODEL1310110042#_bb449972_da61_41cb_91c9_478eb6c9273d
initial amount: NaN
boundary condition: true
constant: false
has only substance units: false
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:386757
type: Species
name: SLC6A10P

metaR PPAm
is: SBO:0000176
notes: GENE_ASSOCIATION: (27068.4) or (27068.1) or (27068.3) or (27068.2) SUBSYSTEM: Oxidative phosphorylation EC Number: 3.6.1.1 Confidence Level: 4 AUTHORS: PMID:10542310,PMID:15533045 NOTES:IF
type: Reaction
is described by: ECO:0000269
reversible: false
fast: false
product: MODEL1310110042#
reactant: MODEL1310110042#
modifier: MODEL1310110042#
kinetic law: MODEL1310110042#
name: inorganic diphosphatase
is version of: http://identifiers.org/ec-code/3.6.1.1

metaR NMNATn
name: nicotinamide-nucleotide adenylyltransferase
is version of: http://identifiers.org/ec-code/2.7.7.1
type: Reaction
notes: GENE_ASSOCIATION: (64802.1) SUBSYSTEM: NAD metabolism EC Number: 2.7.7.1 Confidence Level: 4 AUTHORS: PMID:11027696,PMID:11248244,PMID:12574164 NOTES:IT
product: MODEL1310110042#
is: SBO:0000176
kinetic law: MODEL1310110042#
reversible: false
modifier: MODEL1310110042#
fast: false
reactant: MODEL1310110042#
is described by: ECO:0000269

metaM lnlccoa c
initial concentration: 1.0
type: Species
initial amount: NaN
is: SBO:0000247
is: HMDB01064
has only substance units: false
name: linoleic coenzyme A
constant: false
is: http://identifiers.org/pubchem.compound/5462164
boundary condition: false
notes: FORMULA: C39H62N7O17P3S CHARGE: -4 INCHI: InChI=1/C39H66N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-30(48)67-23-22-41-29(47)20-21-42-37(51)34(50)39(2,3)25-60-66(57,58)63-65(55,56)59-24-28-33(62-64(52,53)54)32(49)38(61-28)46-27-45-31-35(40)43-26-44-36(31)46/h8-9,11-12,26-28,32-34,38,49-50H,4-7,10,13-25H2,1-3H3,(H,41,47)(H,42,51)(H,55,56)(H,57,58)(H2,40,43,44)(H2,52,53,54)/b9-8+,12-11+

metaR MERCPLACCYSt
name: 3-mercaptolactate-cysteine disulfide transport, extracellular
is: SBO:0000185
reactant: MODEL1310110042#
fast: false
product: MODEL1310110042#
is described by: ECO:0000000
kinetic law: MODEL1310110042#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:excretion of 3-mercaptolactate-cysteine disulfide (PMID: 6945862) MM
reversible: false

metaR CRVNCtr
type: Reaction
product: MODEL1310110042#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11788354,PMID:12864740 NOTES:NJ
fast: false
is: SBO:0000185
reversible: true
reactant: MODEL1310110042#
name: fatty acid transport via diffusion
kinetic law: MODEL1310110042#

http://identifiers.org/biomodels.db/MODEL1310110042#_788db5c9_1d49_418b_9890_11b4902961bd
is: Q59FD4
name: HK1
type: Species
constant: false
has only substance units: false
initial concentration: NaN
is encoded by: hsa:3098
initial amount: NaN
is: SBO:0000252
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110042#_a3cad8d4_1366_4ffb_b72a_250e079991b6
constant: false
has only substance units: false
is encoded by: hsa:1807
name: DPYS
type: Species
is: SBO:0000252
initial concentration: NaN
boundary condition: true
initial amount: NaN
is: Q14117

metaM dopasf e
boundary condition: false
has only substance units: false
initial amount: NaN
notes: FORMULA: C8H11NO5S CHARGE: 0 INCHI: InChI=1S/C8H11NO5S/c9-4-3-6-1-2-7(10)8(5-6)14-15(11,12)13/h1-2,5,10H,3-4,9H2,(H,11,12,13) EHMN_ABBREVIATION: C13690
type: Species
name: dopamine 3-O-sulfate
is: SBO:0000247
initial concentration: 1.0
constant: false
is: CHEBI:37946
is: HMDB06275

metaM taur e
is: HMDB00251
name: Taurine
initial amount: NaN
initial concentration: 1.0
notes: FORMULA: C2H7NO3S CHARGE: 0
is: CHEBI:3544
boundary condition: false
is: SBO:0000247
constant: false
has only substance units: false
type: Species
is: C00245

http://identifiers.org/biomodels.db/MODEL1310110042#_9872e28d_9186_47bc_9cde_5f6fb22b73ec
name: _AI971036_1_m
boundary condition: true
type: Species
is encoded by: hsa:AI971036
initial amount: NaN
initial concentration: NaN
constant: false
has only substance units: false
is: SBO:0000252

metaM dhdascb e
boundary condition: false
has only substance units: false
name: dehydroascorbide(1-)
initial concentration: 1.0
is: SBO:0000247
initial amount: NaN
is: CHEBI:58070
is: HMDB01264
constant: false
type: Species
notes: FORMULA: C6H6O6 CHARGE: 0 INCHI: InChI=1S/C6H5O6/c7-1-2(8)5-3(9)4(10)6(11)12-5/h2,7-8H,1H2/q-1 EHMN_ABBREVIATION: C00425

metaR ABTD
type: Reaction
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Pentose phosphate pathway EC Number: 1.1.1.12 Confidence Level: 2 AUTHORS: PMID:12359133,PMID:13922173,PMID:15234337 NOTES:NCD
fast: false
kinetic law: MODEL1310110042#
reversible: true
is: SBO:0000176
name: L-arabinitol 4-dehydrogenase
product: MODEL1310110042#
reactant: MODEL1310110042#

metaR ALDD2x
is version of: http://identifiers.org/ec-code/1.2.1.3
is described by: ECO:0000000
modifier: MODEL1310110042#
reactant: MODEL1310110042#
is version of: http://identifiers.org/ec-code/1.2.1.36
is version of: http://identifiers.org/ec-code/1.2.1.5
is: SBO:0000176
name: aldehyde dehydrogenase (acetaldehyde, NAD)
notes: GENE_ASSOCIATION: (218.1) or (501.1) or (8854.2) or (224.1) or (222.1) or (8854.1) or (221.1) or (216.1) or (8854.3) or (223.1) or (220.1) SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: 1.2.1.3 Confidence Level: 0 AUTHORS: PMID:12616643 NOTES:Only acetaldehyde considered for now. See also 1.2.1.4. Wide specificity, including oxidation of D-glucuronolactone to D-glucarate. Formerly EC 1.1.1.70; r0176
kinetic law: MODEL1310110042#
reversible: false
type: Reaction
product: MODEL1310110042#
fast: false

metaR DOLPMT4 Ler
kinetic law: MODEL1310110042#
reversible: false
product: MODEL1310110042#
fast: false
reactant: MODEL1310110042#
name: dolichyl-phosphate-mannose-glycolipid alpha-mannosyltransferase (liver)
is: SBO:0000185
is described by: ECO:0000000
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: N-glycan synthesis EC Number: 2.4.1.130 Confidence Level: 0 AUTHORS: NOTES:

http://identifiers.org/biomodels.db/MODEL1310110042#_83e17358_4dc2_438f_85bf_038671226fe1
boundary condition: true
name: SYNJ1
has only substance units: false
initial concentration: NaN
is: C9JFZ1
is encoded by: hsa:8867
constant: false
is: SBO:0000252
initial amount: NaN
type: Species

metaR PPAn
notes: GENE_ASSOCIATION: SUBSYSTEM: Miscellaneous EC Number: 3.6.1.1 Confidence Level: 1 AUTHORS: NOTES:
fast: false
is: SBO:0000176
name: inorganic diphosphatase, nuclear
reactant: MODEL1310110042#
reversible: false
type: Reaction
product: MODEL1310110042#
is described by: ECO:0000000
kinetic law: MODEL1310110042#

http://identifiers.org/biomodels.db/MODEL1310110042#_d93568ae_bc6d_4d8f_a879_44b03cd83f70
has only substance units: false
type: Species
is encoded by: hsa:2109
initial amount: NaN
constant: false
boundary condition: true
initial concentration: NaN
is: SBO:0000252
name: ETFB
is: P38117

http://identifiers.org/biomodels.db/MODEL1310110042#_9128a699_ac3b_4982_a9b5_5fa293e60177
type: Species
has only substance units: false
boundary condition: true
constant: false
is encoded by: hsa:AA502753
initial amount: NaN
is: SBO:0000252
name: _AA502753_1_m
initial concentration: NaN

metaR VLCS2r
fast: false
is: SBO:0000176
product: MODEL1310110042#
reversible: false
reactant: MODEL1310110042#
is version of: http://identifiers.org/ec-code/6.2.1.3
kinetic law: MODEL1310110042#
type: Reaction
name: Very-long-chain-fatty-acid-CoA ligase
notes: GENE_ASSOCIATION: (11001.1) SUBSYSTEM: Bile acid synthesis EC Number: 6.2.1.7 Confidence Level: 2 AUTHORS: NOTES:from uniprot and lit - see human recon lit refs divalent cation requirement - unclear which one, reaction inhibited in the presence of EDTA (may just be MgATP or MgATP) - see Kelley and Vessey Biochimica et Biophysica Acta (1994) 1209: 51-55 temporarily will have H+ balance reaction NJ
is described by: ECO:0000304
modifier: MODEL1310110042#

metaM btamp c
notes: FORMULA: C20H27N7O9PS CHARGE: -1 INCHI: InChI=1S/C20H28N7O9PS/c21-17-14-18(23-7-22-17)27(8-24-14)19-16(30)15(29)10(35-19)5-34-37(32,33)36-12(28)4-2-1-3-11-13-9(6-38-11)25-20(31)26-13/h7-11,13,15-16,19,29-30H,1-6H2,(H,32,33)(H2,21,22,23)(H2,25,26,31)/t9-,10+,11-,13-,15+,16+,19+/m0/s1 EHMN_ABBREVIATION: C05921
is: HMDB04220
constant: false
type: Species
boundary condition: false
is: CHEBI:3110
has only substance units: false
initial concentration: 1.0
initial amount: NaN
is: SBO:0000247
name: Biotinyl-5'-AMP

http://identifiers.org/biomodels.db/MODEL1310110042#_fe4909b4_1a5b_4781_ad7d_d982b612754b
initial concentration: NaN
type: Species
boundary condition: true
is encoded by: hsa:4143
name: MAT1A
is: Q00266
initial amount: NaN
is: SBO:0000252
constant: false
has only substance units: false

metaR PCm
is described by: ECO:0000269
reactant: MODEL1310110042#
reversible: false
modifier: MODEL1310110042#
name: pyruvate carboxylase
product: MODEL1310110042#
is version of: http://identifiers.org/ec-code/6.4.1.1
type: Reaction
kinetic law: MODEL1310110042#
is: SBO:0000176
fast: false
notes: GENE_ASSOCIATION: (5091.1) or (5091.2) SUBSYSTEM: Pyruvate metabolism EC Number: 6.4.1.1 Confidence Level: 4 AUTHORS: PMID:6548474 NOTES:TV Metabolism at a glance

metaR GLNSERNaEx
kinetic law: MODEL1310110042#
product: MODEL1310110042#
name: L-serine/L-glutamine Na-dependent exchange (Gln-L in)
reactant: MODEL1310110042#
reversible: false
notes: GENE_ASSOCIATION: (6510.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14530974 NOTES:SAB see Kanai and Hediger 2004 (2003), PMID 14530974
is described by: ECO:0000269
type: Reaction
fast: false
modifier: MODEL1310110042#
is: SBO:0000185

metaR r2497
is: SBO:0000185
product: MODEL1310110042#
reactant: MODEL1310110042#
type: Reaction
fast: false
name: ATP-binding Cassette (ABC) TCDB:3.A.1.203.3
kinetic law: MODEL1310110042#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 0 AUTHORS: PMID:18619829 NOTES:
is described by: ECO:0000000
reversible: false

metaR r1540
name: Neurotransmitter:Sodium Symporter (NSS) TCDB:2.A.22.3.3
kinetic law: MODEL1310110042#
type: Reaction
is described by: ECO:0000000
fast: false
reactant: MODEL1310110042#
notes: GENE_ASSOCIATION: (BE966236.1) or (6240.1) or (6241.1) or (50484.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12719981 NOTES:
modifier: MODEL1310110042#
reversible: false
is version of: http://identifiers.org/ec-code/1.17.4.1
is: SBO:0000185
product: MODEL1310110042#

metaR r1150
reactant: MODEL1310110042#
is described by: ECO:0000000
name: Facilitated diffusion
reversible: false
fast: false
is: SBO:0000185
kinetic law: MODEL1310110042#
notes: GENE_ASSOCIATION: (788.1) SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 0 AUTHORS: PMID:8691743 NOTES:
modifier: MODEL1310110042#
type: Reaction
product: MODEL1310110042#

http://identifiers.org/biomodels.db/MODEL1310110042#_9869977e_9dfe_414e_8d18_0b5ce810b0da
is encoded by: hsa:2181
initial concentration: NaN
boundary condition: true
is: SBO:0000252
type: Species
has only substance units: false
is: O95573
name: ACSL3
initial amount: NaN
constant: false

metaR ACSm
reversible: false
is described by: ECO:0000304
modifier: MODEL1310110042#
product: MODEL1310110042#
fast: false
reactant: MODEL1310110042#
type: Reaction
name: acetyl-CoA synthetase
notes: GENE_ASSOCIATION: (84532.1) SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: 6.2.1.1 Confidence Level: 2 AUTHORS: PMID:11150295,PMID:4326157 NOTES:IF
is version of: http://identifiers.org/ec-code/6.2.1.1
is: SBO:0000176
kinetic law: MODEL1310110042#

metaR r0591
is described by: ECO:0000000
product: MODEL1310110042#
name: Dephospho-CoA nucleotidohydrolase Pantothenate and CoA biosynthesis EC:3.6.1.9
reactant: MODEL1310110042#
is version of: http://identifiers.org/ec-code/1.2.1.5
reversible: true
fast: false
notes: GENE_ASSOCIATION: (220.1) or (218.1) or (221.1) or (222.1) or (U37519.1) SUBSYSTEM: CoA synthesis EC Number: 3.6.1.9 Confidence Level: 0 AUTHORS: PMID:11579996,PMID:11946484 NOTES:
type: Reaction
kinetic law: MODEL1310110042#
modifier: MODEL1310110042#
is: SBO:0000176

metaM gm3 hs g
is: CHEBI:60065
constant: false
type: Species
initial concentration: 1.0
boundary condition: false
is: SBO:0000247
initial amount: NaN
name: alpha-N-acetylneuraminosyl-(2->3)-beta-D-galactosyl-(1->4)-beta-D-glucosylceramide(1-)
notes: FORMULA: C41H72N2O20FULLRCO CHARGE: -1 EHMN_ABBREVIATION: C04730
has only substance units: false

metaM 5fthf m
is: SBO:0000247
boundary condition: false
constant: false
is: CHEBI:57457
type: Species
notes: FORMULA: C20H21N7O7 CHARGE: -2 INCHI: InChI=1S/C20H23N7O7/c21-20-25-16-15(18(32)26-20)27(9-28)12(8-23-16)7-22-11-3-1-10(2-4-11)17(31)24-13(19(33)34)5-6-14(29)30/h1-4,9,12-13,22H,5-8H2,(H,24,31)(H,29,30)(H,33,34)(H4,21,23,25,26,32)/p-2/t12-,13-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01125 EHMN_ABBREVIATION: C03479
is: HMDB01562
name: 5-formyltetrahydrofolate(2-)
has only substance units: false
initial concentration: 1.0
initial amount: NaN

metaR MTHFD2m
notes: GENE_ASSOCIATION: (10797.1) SUBSYSTEM: Folate metabolism EC Number: 1.5.1.5 Confidence Level: 2 AUTHORS: PMID:8218174 NOTES:NCD
fast: false
is described by: ECO:0000254
is version of: http://identifiers.org/ec-code/3.5.4.9
is: SBO:0000176
reversible: true
product: MODEL1310110042#
modifier: MODEL1310110042#
type: Reaction
reactant: MODEL1310110042#
name: methylenetetrahydrofolate dehydrogenase (NAD), mitochondrial
kinetic law: MODEL1310110042#

metaM Nacasp m
initial amount: NaN
is: SBO:0000247
is: HMDB00812
notes: FORMULA: C6H7NO5 CHARGE: -2 INCHI: InChI=1S/C6H9NO5/c1-3(8)7-4(6(11)12)2-5(9)10/h4H,2H2,1H3,(H,7,8)(H,9,10)(H,11,12)/p-2/t4-/m0/s1 EHMN_ABBREVIATION: C01042
initial concentration: 1.0
constant: false
is: CHEBI:16953
type: Species
boundary condition: false
has only substance units: false
name: N-acetyl-L-aspartate(2-)

metaM 3hpp m
boundary condition: false
is: HMDB00700
initial amount: NaN
has only substance units: false
type: Species
is: CHEBI:16510
constant: false
name: 3-hydroxypropionate
notes: FORMULA: C3H5O3 CHARGE: -1 INCHI: InChI=1S/C3H6O3/c4-2-1-3(5)6/h4H,1-2H2,(H,5,6)/p-1 HEPATONET_1.0_ABBREVIATION: HC00625 EHMN_ABBREVIATION: C01013
initial concentration: 1.0
is: SBO:0000247

metaM 3ddecdicoa x
has only substance units: false
notes: FORMULA: C33H50N7O17P3S CHARGE: -4
is: HMDB03952
constant: false
is: C05280
boundary condition: false
initial concentration: 1.0
is: SBO:0000247
type: Species
initial amount: NaN
name: 3,6-dodecadienoylcoa

metaM dhdascb c
boundary condition: false
initial concentration: 1.0
name: dehydroascorbide(1-)
is: SBO:0000247
initial amount: NaN
notes: FORMULA: C6H6O6 CHARGE: 0 INCHI: InChI=1S/C6H5O6/c7-1-2(8)5-3(9)4(10)6(11)12-5/h2,7-8H,1H2/q-1 EHMN_ABBREVIATION: C00425
is: CHEBI:58070
type: Species
is: HMDB01264
constant: false
has only substance units: false

metaR GLCAASE7ly
product: MODEL1310110042#
notes: GENE_ASSOCIATION: (2990.1) SUBSYSTEM: Chondroitin sulfate degradation EC Number: 3.2.1.31 Confidence Level: 4 AUTHORS: PMID:3468507,PMID:3924735,PMID:3987656 NOTES:NCD
type: Reaction
reversible: false
kinetic law: MODEL1310110042#
fast: false
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.2.1.31
name: beta-glucuronidase, lysosomal
modifier: MODEL1310110042#
reactant: MODEL1310110042#
is described by: ECO:0000000

metaR EX ha LPAREN e RPAREN
kinetic law: MODEL1310110042#
reactant: MODEL1310110042#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: hyaluronan exchange
type: Reaction

metaM gluside hs l
is: SBO:0000247
type: Species
name: D-glucosyl-N-acylsphingosine
initial amount: NaN
boundary condition: false
is: CHEBI:18368
notes: FORMULA: C24H46NO7FULLRCO CHARGE: 0 EHMN_ABBREVIATION: C01190
has only substance units: false
initial concentration: 1.0
constant: false

http://identifiers.org/biomodels.db/MODEL1310110042#_a91d3420_4816_41a0_95ac_aae02b01f246
initial amount: NaN
name: GK
is: P32189
constant: false
has only substance units: false
is encoded by: hsa:2710
boundary condition: true
type: Species
initial concentration: NaN
is: SBO:0000252

metaM hpdca e
initial amount: NaN
notes: FORMULA: C17H33O2 CHARGE: -1 INCHI: InChI=1S/C17H34O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17(18)19/h2-16H2,1H3,(H,18,19)/p-1
name: margarate
is: CHEBI:32366
initial concentration: 1.0
type: Species
is: SBO:0000247
is: HMDB02259
constant: false
has only substance units: false
boundary condition: false

metaM biocyt n
has only substance units: false
initial concentration: 1.0
is: http://identifiers.org/pubchem.compound/7886
is: SBO:0000247
type: Species
is: HMDB03134
notes: FORMULA: C16H28N4O4S CHARGE: 0 INCHI: InChI=1/C16H28N4O4S/c17-10(15(22)23)5-3-4-8-18-13(21)7-2-1-6-12-14-11(9-25-12)19-16(24)20-14/h10-12,14H,1-9,17H2,(H,18,21)(H,22,23)(H2,19,20,24)/t10-,11-,12-,14-/m0/s1 EHMN_ABBREVIATION: C05552
boundary condition: false
is: C05552
name: Biocytin
initial amount: NaN
constant: false

metaM udpg r
initial amount: NaN
has only substance units: false
name: [(2R,3S,4R,5R)-5-(2,4-dioxo-1,2,3,4-tetrahydropyrimidin-1-yl)-3,4-dihydroxyoxolan-2-yl]methyl {[(3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl phosphonato]oxy}phosphonate
constant: false
initial concentration: 1.0
type: Species
is: SBO:0000247
is: HMDB00286
is: CHEBI:58367
boundary condition: false
notes: FORMULA: C15H22N2O17P2 CHARGE: -2 INCHI: InChI=1S/C15H24N2O17P2/c18-3-5-8(20)10(22)12(24)14(32-5)33-36(28,29)34-35(26,27)30-4-6-9(21)11(23)13(31-6)17-2-1-7(19)16-15(17)25/h1-2,5-6,8-14,18,20-24H,3-4H2,(H,26,27)(H,28,29)(H,16,19,25)/p-2/t5-,6-,8-,9-,10+,11-,12-,13-,14?/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00038 EHMN_ABBREVIATION: C00029

metaM ttdca e
is: C06424
type: Species
initial concentration: 1.0
notes: FORMULA: C14H27O2 CHARGE: -1 EHMN_ABBREVIATION: C06424
name: tetradecanoate (n-C14:0)
constant: false
has only substance units: false
is: SBO:0000247
is: HMDB00806
initial amount: NaN
boundary condition: false
is: CHEBI:30807

metaM pro L m
constant: false
name: L-proline
is: SBO:0000247
initial amount: NaN
type: Species
is: CHEBI:17203
boundary condition: false
notes: FORMULA: C5H9NO2 CHARGE: 0 INCHI: InChI=1S/C5H9NO2/c7-5(8)4-2-1-3-6-4/h4,6H,1-3H2,(H,7,8)/t4-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00145
is: HMDB00162
has only substance units: false
initial concentration: 1.0

metaM 34dhoxmand c
is: SBO:0000247
has only substance units: false
notes: FORMULA: C8H7O5 CHARGE: -1 INCHI: InChI=1S/C8H8O5/c9-5-2-1-4(3-6(5)10)7(11)8(12)13/h1-3,7,9-11H,(H,12,13) HEPATONET_1.0_ABBREVIATION: HC01517 EHMN_ABBREVIATION: C05580
type: Species
is: HMDB01866
initial concentration: 1.0
name: 3,4-Dihydroxymandelate
constant: false
boundary condition: false
initial amount: NaN
is: CHEBI:27637

metaR ALAt4
is: SBO:0000185
product: MODEL1310110042#
reversible: false
type: Reaction
fast: false
name: Alanine-Sodium symporter
kinetic law: MODEL1310110042#
is described by: ECO:0000269
reactant: MODEL1310110042#
notes: GENE_ASSOCIATION: (54407.1) or (6542.1) or (11254.1) or (6541.1) or (81539.1) or (55089.1) or (84889.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10747860,PMID:10891391,PMID:10930503,PMID:11325958,PMID:11342143,PMID:11414754,PMID:11591158,PMID:11891586,PMID:12049641,PMID:1348489,PMID:14770310,PMID:7534987,PMID:8954799 NOTES:tv Mendz pg. 201 Reversibility is unclear.
modifier: MODEL1310110042#

metaR r0590
is version of: http://identifiers.org/ec-code/1.2.1.5
name: ATP:pantetheine-4-phosphate adenylyltransferase Pantothenate and CoA biosynthesis EC:2.7.7.3
reactant: MODEL1310110042#
product: MODEL1310110042#
fast: false
reversible: false
kinetic law: MODEL1310110042#
modifier: MODEL1310110042#
type: Reaction
is: SBO:0000176
notes: GENE_ASSOCIATION: (220.1) or (218.1) or (221.1) or (222.1) or (U37519.1) SUBSYSTEM: CoA synthesis EC Number: 2.7.7.3 Confidence Level: 0 AUTHORS: PMID:11923312,PMID:11994049,PMID:13163064,PMID:15893380 NOTES:
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110042#_7f29d415_cefa_4529_81c1_96ee029faa27
has only substance units: false
type: Species
name: ALDOB
constant: false
is: P05062
initial concentration: NaN
initial amount: NaN
is: SBO:0000252
is encoded by: hsa:229
boundary condition: true

metaR VLCS2p
fast: false
product: MODEL1310110042#
reversible: false
notes: GENE_ASSOCIATION: (11001.1) SUBSYSTEM: Bile acid synthesis EC Number: 6.2.1.7 Confidence Level: 2 AUTHORS: PMID:10479480 NOTES:from uniprot and lit - see human recon lit refs divalent cation requirement - unclear which one, reaction inhibited in the presence of EDTA (may just be MgATP or MgATP) - see Kelley and Vessey Biochimica et Biophysica Acta (1994) 1209: 51-55 temporarily will have H+ balance reaction NJ
is: SBO:0000176
is version of: http://identifiers.org/ec-code/6.2.1.3
kinetic law: MODEL1310110042#
name: Very-long-chain-fatty-acid-CoA ligase
reactant: MODEL1310110042#
modifier: MODEL1310110042#
type: Reaction
is described by: ECO:0000304

metaM hs deg17 l
initial concentration: 1.0
boundary condition: false
constant: false
has only substance units: false
is: CHEBI:21338
name: heparan sulfate, degradation product 17
type: Species
is: HMDB02704
is: SBO:0000247
notes: FORMULA: C43H65N2O48S4 CHARGE: -5
initial amount: NaN

metaR FAOXC163Gm
kinetic law: MODEL1310110042#
product: MODEL1310110042#
reactant: MODEL1310110042#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: isomerization(C16:3)gm
type: Reaction

metaR NRVNCt
product: MODEL1310110042#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11788354,PMID:12864740 NOTES:NJ
name: fatty acid transport via diffusion
reversible: true
is: SBO:0000185
is described by: ECO:0000000
kinetic law: MODEL1310110042#
type: Reaction
reactant: MODEL1310110042#

metaR CYTK1
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: NOTES:
modifier: MODEL1310110042#
type: Reaction
fast: false
is version of: http://identifiers.org/ec-code/2.7.4.14
product: MODEL1310110042#
reactant: MODEL1310110042#
kinetic law: MODEL1310110042#
is: SBO:0000176
is described by: ECO:0000269
reversible: true
name: cytidylate kinase (CMP)

metaR FATP6t
is version of: http://identifiers.org/ec-code/6.2.1.7
product: MODEL1310110042#
type: Reaction
is version of: http://identifiers.org/ec-code/6.2.1.3
reactant: MODEL1310110042#
reversible: true
is described by: ECO:0000269
name: fatty acid electroneutral transport
fast: false
is: SBO:0000185
kinetic law: MODEL1310110042#
modifier: MODEL1310110042#
notes: GENE_ASSOCIATION: (10998.1) or (11001.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10479480,PMID:12856180,PMID:15522816 NOTES:electroneutral transport NJ

metaR EX HC00229 LPAREN e RPAREN
kinetic law: MODEL1310110042#
reactant: MODEL1310110042#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of Isomaltose
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110042#_5c3c3416_8c27_4604_a3ea_6ea101e46e1c
boundary condition: true
has only substance units: false
is encoded by: hsa:2181
type: Species
name: ACSL3
constant: false
is: SBO:0000252
initial concentration: NaN
is: B3KMA6
initial amount: NaN

metaR EX lcts LPAREN e RPAREN
kinetic law: MODEL1310110042#
reactant: MODEL1310110042#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Lactose exchange
type: Reaction

metaR CHATn
type: Reaction
reversible: true
is: SBO:0000176
name: Choline O-acetyltransferase
kinetic law: MODEL1310110042#
is version of: http://identifiers.org/ec-code/2.3.1.6
reactant: MODEL1310110042#
notes: GENE_ASSOCIATION: (1103.4) or (1103.1) or (1103.3) or (1103.2) SUBSYSTEM: Glycerophospholipid metabolism EC Number: 2.3.1.6 Confidence Level: 4 AUTHORS: PMID:10861222 NOTES:NJ
fast: false
modifier: MODEL1310110042#
product: MODEL1310110042#
is described by: ECO:0000269

metaM imp c
boundary condition: false
notes: FORMULA: C10H11N4O8P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00128 EHMN_ABBREVIATION: C00130
is: C00130
initial amount: NaN
type: Species
initial concentration: 1.0
is: HMDB00175
is: SBO:0000247
has only substance units: false
constant: false
name: IMP
is: CHEBI:58053

metaR GLXtm
is: SBO:0000185
fast: false
name: glyoxylate transport, mitochondrial
reversible: true
type: Reaction
product: MODEL1310110042#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 1 AUTHORS: PMID:15240345 NOTES:NCD
reactant: MODEL1310110042#
is described by: ECO:0000000
kinetic law: MODEL1310110042#

http://identifiers.org/biomodels.db/MODEL1310110042#_485ee1c4_be12_47b2_b116_03f8d29a10b9
type: Species
initial concentration: NaN
has only substance units: false
is encoded by: hsa:6547
name: SLC8A3
constant: false
is: B3KU59
initial amount: NaN
boundary condition: true
is: SBO:0000252

metaR A MANASEly
name: alpha-mannosidase, lysosomal
type: Reaction
notes: GENE_ASSOCIATION: (4125.1) SUBSYSTEM: N-glycan degradation EC Number: 3.2.1.24 Confidence Level: 0 AUTHORS: PMID:8910458 NOTES:NCD
kinetic law: MODEL1310110042#
reactant: MODEL1310110042#
is version of: http://identifiers.org/ec-code/3.2.1.24
reversible: false
fast: false
is described by: ECO:0000000
modifier: MODEL1310110042#
is: SBO:0000176
product: MODEL1310110042#

http://identifiers.org/biomodels.db/MODEL1310110042#_80b8df6c_5869_4c8e_98a5_c05ba8e87caf
has only substance units: false
initial amount: NaN
is: SBO:0000252
is: B3KVI7
name: IVD
boundary condition: true
constant: false
is encoded by: hsa:3712
initial concentration: NaN
type: Species

metaR r1147
type: Reaction
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
product: MODEL1310110042#
fast: false
is: SBO:0000185
kinetic law: MODEL1310110042#
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:16919238,PMID:17173541,PMID:18406340,PMID:8132483 NOTES:
is described by: ECO:0000000
reactant: MODEL1310110042#

metaR r2520
is: SBO:0000185
product: MODEL1310110042#
type: Reaction
reactant: MODEL1310110042#
is described by: ECO:0000000
kinetic law: MODEL1310110042#
fast: false
name: Mitochondrial Carrier (MC) TCDB:2.A.29.2.1
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:15845418 NOTES:
reversible: true

metaM ivcoa c
type: Species
initial concentration: 1.0
name: Isovaleryl-CoA
is: HMDB01113
constant: false
is: SBO:0000247
boundary condition: false
notes: FORMULA: C26H40N7O17P3S CHARGE: -4
has only substance units: false
initial amount: NaN

metaR RE0453N
name: RE0453
notes: GENE_ASSOCIATION: (4830.1) or (4831.1) SUBSYSTEM: Pyrimidine synthesis EC Number: 2.7.4.6 Confidence Level: 0 AUTHORS: PMID:3026468 NOTES:
kinetic law: MODEL1310110042#
reactant: MODEL1310110042#
reversible: true
type: Reaction
product: MODEL1310110042#
is described by: ECO:0000000
fast: false
is version of: http://identifiers.org/ec-code/2.7.4.6
modifier: MODEL1310110042#
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110042#_1a074134_ab6f_486f_b9f7_b141f9c3c1f8
constant: false
initial concentration: NaN
type: Species
initial amount: NaN
is: Q13907
has only substance units: false
is encoded by: hsa:3422
is: SBO:0000252
name: IDI1
boundary condition: true

metaM c6crn x
initial concentration: 1.0
name: hexanoyl carnitine
type: Species
initial amount: NaN
has only substance units: false
is: HMDB00705
is: SBO:0000247
constant: false
notes: FORMULA: C13H25NO4 CHARGE: 0
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110042#_28a42e89_a56c_4a3f_bd49_5a1045df577a
has only substance units: false
is encoded by: hsa:100
is: SBO:0000252
initial concentration: NaN
is: P00813
name: ADA
constant: false
type: Species
boundary condition: true
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110042#_0566b721_dc8b_4bb6_bb85_6535141caba8
constant: false
is encoded by: hsa:251
type: Species
is: SBO:0000252
name: ALPPL2
initial amount: NaN
is: P10696
initial concentration: NaN
boundary condition: true
has only substance units: false

metaR r1549
is: SBO:0000185
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
type: Reaction
reversible: true
product: MODEL1310110042#
is described by: ECO:0000000
reactant: MODEL1310110042#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
kinetic law: MODEL1310110042#
fast: false

metaR r0614
reversible: true
is: SBO:0000176
name: N-[(R)-4-Phosphopantothenoyl]-L-cysteine carboxy-lyase Pantothenate and CoA biosynthesis EC:4.1.1.36
type: Reaction
reactant: MODEL1310110042#
is described by: ECO:0000000
kinetic law: MODEL1310110042#
notes: GENE_ASSOCIATION: SUBSYSTEM: CoA synthesis EC Number: 4.1.1.36 Confidence Level: 0 AUTHORS: PMID:11923312,PMID:13630913,PMID:15893380,PMID:4459135,PMID:6061681 NOTES:
product: MODEL1310110042#
fast: false

metaM sphs1p r
boundary condition: false
is: SBO:0000247
constant: false
is: HMDB00277
initial concentration: 1.0
name: sphingosine 1-phosphate(1-)
type: Species
is: CHEBI:60119
has only substance units: false
initial amount: NaN
notes: FORMULA: C18H37NO5P CHARGE: -1 INCHI: InChI=1S/C18H38NO5P/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-18(20)17(19)16-24-25(21,22)23/h14-15,17-18,20H,2-13,16,19H2,1H3,(H2,21,22,23)/p-1/b15-14+/t17-,18+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01702 EHMN_ABBREVIATION: C06124

metaM bilglcur e
constant: false
notes: FORMULA: C39H44N4O12 CHARGE: 0 INCHI: InChI=1S/C39H44N4O12/c1-7-20-19(6)36(50)43-27(20)14-25-18(5)23(10-12-31(46)54-39-34(49)32(47)33(48)35(55-39)38(52)53)29(41-25)15-28-22(9-11-30(44)45)17(4)24(40-28)13-26-16(3)21(8-2)37(51)42-26/h7-8,13-14,32-35,39-41,47-49H,1-2,9-12,15H2,3-6H3,(H,42,51)(H,43,50)(H,44,45)(H,52,53)/p-2/b26-13+,27-14+/t32-,33-,34+,35-,39+/m0/s1 EHMN_ABBREVIATION: C03374
type: Species
name: mono(glucosyluronic acid)bilirubin(2-)
has only substance units: false
is: CHEBI:57767
is: SBO:0000247
initial amount: NaN
boundary condition: false
initial concentration: 1.0

metaR PNTK
name: pantothenate kinase
fast: false
is version of: http://identifiers.org/ec-code/2.7.1.33
reactant: MODEL1310110042#
is described by: ECO:0000269
is: SBO:0000176
notes: GENE_ASSOCIATION: (79646.1) or (80025.2) or (53354.1) or (53354.3) or (80025.1) or (53354.2) or (80025.3) or (80025.4) or (55229.1) SUBSYSTEM: CoA synthesis EC Number: Confidence Level: 4 AUTHORS: NOTES:
product: MODEL1310110042#
modifier: MODEL1310110042#
reversible: false
type: Reaction
kinetic law: MODEL1310110042#

metaM hs deg2 l
initial concentration: 1.0
name: heparan sulfate, degradation product 2
type: Species
constant: false
is: SBO:0000247
is: CHEBI:17180
boundary condition: false
initial amount: NaN
notes: FORMULA: C79H116N5O96S10 CHARGE: -11
has only substance units: false
is: HMDB01352

metaR r2521
kinetic law: MODEL1310110042#
type: Reaction
fast: false
name: Utilized transport
is described by: ECO:0000000
is: SBO:0000185
product: MODEL1310110042#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:8691743 NOTES:
reversible: true
reactant: MODEL1310110042#

metaR r1548
type: Reaction
reactant: MODEL1310110042#
is described by: ECO:0000000
product: MODEL1310110042#
reversible: true
kinetic law: MODEL1310110042#
is: SBO:0000185
fast: false
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:

metaM mmcoa S m
is: CHEBI:57327
constant: false
initial concentration: 1.0
type: Species
has only substance units: false
is: HMDB02310
name: (S)-methylmalonyl-CoA(5-)
boundary condition: false
initial amount: NaN
notes: FORMULA: C25H35N7O19P3S CHARGE: -5 INCHI: InChI=1S/C25H40N7O19P3S/c1-12(23(37)38)24(39)55-7-6-27-14(33)4-5-28-21(36)18(35)25(2,3)9-48-54(45,46)51-53(43,44)47-8-13-17(50-52(40,41)42)16(34)22(49-13)32-11-31-15-19(26)29-10-30-20(15)32/h10-13,16-18,22,34-35H,4-9H2,1-3H3,(H,27,33)(H,28,36)(H,37,38)(H,43,44)(H,45,46)(H2,26,29,30)(H2,40,41,42)/p-5/t12-,13+,16+,17+,18-,22+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00495
is: SBO:0000247

metaR RE0453M
type: Reaction
is described by: ECO:0000000
kinetic law: MODEL1310110042#
notes: GENE_ASSOCIATION: (4833.1) SUBSYSTEM: Pyrimidine synthesis EC Number: 2.7.4.6 Confidence Level: 0 AUTHORS: PMID:3026468 NOTES:
modifier: MODEL1310110042#
product: MODEL1310110042#
reactant: MODEL1310110042#
is version of: http://identifiers.org/ec-code/2.7.4.6
is: SBO:0000176
fast: false
name: RE0453
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110042#_8d7a2abe_2f40_4875_af53_82c58951baf0
initial concentration: NaN
has only substance units: false
type: Species
is encoded by: hsa:641371
is: SBO:0000252
name: ACOT1
boundary condition: true
constant: false
initial amount: NaN
is: E9KL42

metaR DHCRD1
is: SBO:0000176
product: MODEL1310110042#
name: dihydroceramide desaturase
type: Reaction
notes: GENE_ASSOCIATION: (8560.1) or (8560.2) SUBSYSTEM: Sphingolipid metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:9188692 NOTES:NJ
is described by: ECO:0000269
kinetic law: MODEL1310110042#
reversible: false
reactant: MODEL1310110042#
fast: false
modifier: MODEL1310110042#

metaM acald m
initial concentration: 1.0
type: Species
has only substance units: false
notes: FORMULA: C2H4O CHARGE: 0 INCHI: InChI=1S/C2H4O/c1-2-3/h2H,1H3 HEPATONET_1.0_ABBREVIATION: HC00087 EHMN_ABBREVIATION: C00084
is: HMDB00990
is: SBO:0000247
is: CHEBI:15343
name: acetaldehyde
initial amount: NaN
constant: false
boundary condition: false

metaM pyr e
boundary condition: false
is: HMDB00243
has only substance units: false
is: SBO:0000247
constant: false
is: CHEBI:15361
initial concentration: 1.0
type: Species
name: pyruvate
initial amount: NaN
notes: FORMULA: C3H3O3 CHARGE: -1 INCHI: InChI=1S/C3H4O3/c1-2(4)3(5)6/h1H3,(H,5,6)/p-1 HEPATONET_1.0_ABBREVIATION: HC00032 EHMN_ABBREVIATION: C00022

metaR r0615
is version of: http://identifiers.org/ec-code/2.3.1.168
kinetic law: MODEL1310110042#
product: MODEL1310110042#
fast: false
type: Reaction
modifier: MODEL1310110042#
notes: GENE_ASSOCIATION: (1629.1) SUBSYSTEM: Arginine and Proline Metabolism EC Number: 1.5.1.2 Confidence Level: 0 AUTHORS: PMID:12514185,PMID:3768405,PMID:6250440,PMID:675382 NOTES:
is described by: ECO:0000000
reactant: MODEL1310110042#
reversible: true
is: SBO:0000176
name: trans-4-Hydroxy-L-proline:NAD+ 5-oxidoreductase Arginine and proline metabolism EC:1.5.1.2

http://identifiers.org/biomodels.db/MODEL1310110042#_b7c5aaf6_6e7c_4e44_b12a_d9f371d99ca3
is: SBO:0000252
has only substance units: false
constant: false
is encoded by: hsa:5230
initial concentration: NaN
is: P00558
name: PGK1
boundary condition: true
initial amount: NaN
type: Species

metaM arachcoa x
has only substance units: false
type: Species
boundary condition: false
constant: false
notes: FORMULA: C41H70N7O17P3S CHARGE: -4 INCHI: InChI=1S/C41H74N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-32(50)69-25-24-43-31(49)22-23-44-39(53)36(52)41(2,3)27-62-68(59,60)65-67(57,58)61-26-30-35(64-66(54,55)56)34(51)40(63-30)48-29-47-33-37(42)45-28-46-38(33)48/h28-30,34-36,40,51-52H,4-27H2,1-3H3,(H,43,49)(H,44,53)(H,57,58)(H,59,60)(H2,42,45,46)(H2,54,55,56)/t30-,34-,35-,36+,40-/m1/s1 EHMN_ABBREVIATION: C02041
initial amount: NaN
is: SBO:0000247
name: arachidyl coenzyme A
is: HMDB04258
initial concentration: 1.0
is: CHEBI:15527

metaR CGMPt
type: Reaction
name: cGMP transport (ATP-dependent)
is: SBO:0000185
modifier: MODEL1310110042#
kinetic law: MODEL1310110042#
fast: false
notes: GENE_ASSOCIATION: (10257.1) or (10057.2) or (10057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:11447229,PMID:12637526,PMID:12835412,PMID:14507663,PMID:15631998 NOTES:IT
reactant: MODEL1310110042#
is described by: ECO:0000269
reversible: false
product: MODEL1310110042#

metaR GUAPRT
fast: false
is version of: http://identifiers.org/ec-code/2.4.2.8
reversible: false
type: Reaction
notes: GENE_ASSOCIATION: (3251.1) SUBSYSTEM: Nucleotide salvage pathway EC Number: 2.4.2.8 Confidence Level: 4 AUTHORS: PMID:3008106,PMID:6853490 NOTES:Guanine and 6-mercaptopurine can replace hypoxanthine EC added (2.4.2.7 makes the same reaction) IT
product: MODEL1310110042#
name: guanine phosphoribosyltransferase
reactant: MODEL1310110042#
kinetic law: MODEL1310110042#
is described by: ECO:0000269
is: SBO:0000176
modifier: MODEL1310110042#

metaR FAOXC61C4m
kinetic law: MODEL1310110042#
product: MODEL1310110042#
reactant: MODEL1310110042#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C6:1-->C4:0)m
type: Reaction

metaR EX phe L LPAREN e RPAREN
kinetic law: MODEL1310110042#
reactant: MODEL1310110042#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for L-phenylalanine
type: Reaction

metaM 5thf e
constant: false
notes: FORMULA: C39H45N11O18 CHARGE: -6
type: Species
is: SBO:0000247
name: pentaglutamyl folate (THF)
is: HMDB06487
initial amount: NaN
boundary condition: false
initial concentration: 1.0
has only substance units: false

metaR FATP3t
is: SBO:0000185
reactant: MODEL1310110042#
product: MODEL1310110042#
modifier: MODEL1310110042#
reversible: true
fast: false
type: Reaction
is described by: ECO:0000269
kinetic law: MODEL1310110042#
notes: GENE_ASSOCIATION: (376497.1) or (376497.2) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12856180,PMID:15522816 NOTES:electroneutral transport NJ
name: fatty acid electroneutral transport

http://identifiers.org/biomodels.db/MODEL1310110042#_aebe8eac_5991_4c49_9b56_67694b350cfa
type: Species
constant: false
boundary condition: true
has only substance units: false
is encoded by: hsa:9962
initial amount: NaN
is: SBO:0000252
initial concentration: NaN
name: SLC23A2

metaR C3DCe
kinetic law: MODEL1310110042#
product: MODEL1310110042#
reactant: MODEL1310110042#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of malonyl carnitine into extra cellular space
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110042#_02b69a14_cee7_4951_8c14_656a5e775fbc
name: VNN3
boundary condition: true
type: Species
has only substance units: false
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:55350
is: SBO:0000252
constant: false

metaR r0616
is: SBO:0000176
reversible: true
type: Reaction
reactant: MODEL1310110042#
is described by: ECO:0000000
modifier: MODEL1310110042#
notes: GENE_ASSOCIATION: (C7orf24.1) SUBSYSTEM: Arginine and Proline Metabolism EC Number: 1.5.1.2 Confidence Level: 0 AUTHORS: PMID:12514185,PMID:3768405,PMID:6250440,PMID:675382 NOTES:
name: trans-4-Hydroxy-L-proline:NAD+ 5-oxidoreductase Arginine and proline metabolism EC:1.5.1.2
fast: false
kinetic law: MODEL1310110042#
product: MODEL1310110042#

metaR FAOXC185m
kinetic law: MODEL1310110042#
product: MODEL1310110042#
reactant: MODEL1310110042#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: isomerization(C18:5)m
type: Reaction

metaR GLXtp
fast: false
reversible: true
name: glyoxylate transport, peroxisomal
type: Reaction
product: MODEL1310110042#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 1 AUTHORS: PMID:15240345 NOTES:NCD
is: SBO:0000185
kinetic law: MODEL1310110042#
reactant: MODEL1310110042#
is described by: ECO:0000000

metaR r1144
is: SBO:0000185
fast: false
reactant: MODEL1310110042#
product: MODEL1310110042#
type: Reaction
name: Major Facilitator(MFS) TCDB:2.A.18.6.3
kinetic law: MODEL1310110042#
notes: GENE_ASSOCIATION: (788.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:10823827 NOTES:
is described by: ECO:0000000
modifier: MODEL1310110042#
reversible: false

metaR ALATHRNaEx
modifier: MODEL1310110042#
is: SBO:0000185
fast: false
reactant: MODEL1310110042#
reversible: false
notes: GENE_ASSOCIATION: (6509.1) or (6510.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14530974 NOTES:SAB see Kanai and Hediger 2004 (2003), PMID 14530974
kinetic law: MODEL1310110042#
name: L-alanine/L-threonine Na-dependent exchange (Ala-L in)
type: Reaction
product: MODEL1310110042#
is described by: ECO:0000269

metaR r0721
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.17 Confidence Level: 0 AUTHORS: PMID:8012501,PMID:8188243 NOTES:
is described by: ECO:0000000
product: MODEL1310110042#
kinetic law: MODEL1310110042#
reactant: MODEL1310110042#
fast: false
name: (S)-3-Hydroxytetradecanoyl-CoA hydro-lyase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:4.2.1.17
is: SBO:0000176
reversible: false

metaM udpacgal c
type: Species
is: SBO:0000247
is: HMDB00304
notes: FORMULA: C17H25N3O17P2 CHARGE: -2 INCHI: InChI=1S/C17H27N3O17P2/c1-6(22)18-10-13(26)11(24)7(4-21)35-16(10)36-39(31,32)37-38(29,30)33-5-8-12(25)14(27)15(34-8)20-3-2-9(23)19-17(20)28/h2-3,7-8,10-16,21,24-27H,4-5H2,1H3,(H,18,22)(H,29,30)(H,31,32)(H,19,23,28)/p-2/t7-,8-,10-,11+,12-,13-,14-,15-,16?/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00190 EHMN_ABBREVIATION: C00203
boundary condition: false
is: CHEBI:57847
initial amount: NaN
name: UDP-N-acetyl-D-galactosamine(2-)
initial concentration: 1.0
constant: false
has only substance units: false

metaR FORMCOAtx
type: Reaction
reactant: MODEL1310110042#
name: formyl coa transport
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: NOTES:unknown mechanism see Verhoeven 11591435 and clayton 11356171 - added for peroxisomal oxidation of fatty acids NJ
kinetic law: MODEL1310110042#
is: SBO:0000185
is described by: ECO:0000000
reversible: true
fast: false
product: MODEL1310110042#

http://identifiers.org/biomodels.db/MODEL1310110042#_274b9049_8d7f_459b_a5fa_cdc3e112bd0a
type: Species
constant: false
is encoded by: hsa:130367
initial concentration: NaN
initial amount: NaN
is: SBO:0000252
has only substance units: false
is: Q8IWX5
name: SGPP2
boundary condition: true

metaR 34HPPte
reactant: MODEL1310110042#
is: SBO:0000185
is described by: ECO:0000134
fast: false
kinetic law: MODEL1310110042#
name: Transport of 3-(4-hydroxyphenyl)pyruvate
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
reversible: true
product: MODEL1310110042#
type: Reaction

metaM 5oxpro e
is: CHEBI:57606
type: Species
initial amount: NaN
is: SBO:0000247
name: 5-oxoprolinate
is: HMDB00267
notes: FORMULA: C5H6NO3 CHARGE: -1 INCHI: InChI=1S/C5H7NO3/c7-4-2-1-3(6-4)5(8)9/h3H,1-2H2,(H,6,7)(H,8,9)/p-1
boundary condition: false
has only substance units: false
constant: false
initial concentration: 1.0

metaR FAOXTC162TC142m
kinetic law: MODEL1310110042#
product: MODEL1310110042#
reactant: MODEL1310110042#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation trans(C16:2-->C14:2)m
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110042#_c9bc8240_90f8_43d5_a38d_0f2bbf5f83e1
has only substance units: false
is: SBO:0000252
initial amount: NaN
is: B7Z5G2
is encoded by: hsa:2629
name: GBA
type: Species
constant: false
boundary condition: true
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110042#_3c1d08c5_d77d_4dd9_942b_b1c068df16a1
type: Species
is encoded by: hsa:AI345944
name: _AI345944_1_m
initial concentration: NaN
boundary condition: true
has only substance units: false
is: SBO:0000252
constant: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110042#_ecb79ff1_d1ae_43e5_9ffe_b28cd5196149
initial concentration: NaN
type: Species
has only substance units: false
name: EHHADH
is: Q9NY65
constant: false
is encoded by: hsa:1962
initial amount: NaN
is: SBO:0000252
boundary condition: true

metaM dectricoa x
boundary condition: false
initial amount: NaN
has only substance units: false
type: Species
initial concentration: 1.0
is: SBO:0000247
is: http://identifiers.org/pubchem.compound/16019966
constant: false
notes: FORMULA: C31H44N7O17P3S CHARGE: -4
name: 2,4,7-decatrienoylcoa

metaR r0617
kinetic law: MODEL1310110042#
fast: false
type: Reaction
product: MODEL1310110042#
notes: GENE_ASSOCIATION: SUBSYSTEM: Arginine and Proline Metabolism EC Number: 1.5.1.2 Confidence Level: 0 AUTHORS: PMID:12514185,PMID:3768405,PMID:6250440,PMID:675382 NOTES:
is described by: ECO:0000000
reactant: MODEL1310110042#
reversible: true
name: trans-4-Hydroxy-L-proline:NADP+ 5-oxidoreductase Arginine and proline metabolism EC:1.5.1.2
is: SBO:0000176

metaM HC01397 x
notes: FORMULA: C37H62N7O18P3S CHARGE: -4 INCHI: InChI=1S/C37H66N7O18P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-25(45)20-28(47)66-19-18-39-27(46)16-17-40-35(50)32(49)37(2,3)22-59-65(56,57)62-64(54,55)58-21-26-31(61-63(51,52)53)30(48)36(60-26)44-24-43-29-33(38)41-23-42-34(29)44/h23-26,30-32,36,45,48-49H,4-22H2,1-3H3,(H,39,46)(H,40,50)(H,54,55)(H,56,57)(H2,38,41,42)(H2,51,52,53)/t25-,26+,30+,31+,32-,36+/m0/s1 EHMN_ABBREVIATION: C05258
type: Species
boundary condition: false
constant: false
initial amount: NaN
is: CHEBI:27402
initial concentration: 1.0
has only substance units: false
name: (S)-3-Hydroxyhexadecanoyl-CoA
is: SBO:0000247

metaR ST8SIA11
kinetic law: MODEL1310110042#
notes: GENE_ASSOCIATION: (6489.1) SUBSYSTEM: Sphingolipid metabolism EC Number: 2.4.99.8 Confidence Level: 4 AUTHORS: PMID:9199191 NOTES:NJ
is: SBO:0000176
reactant: MODEL1310110042#
reversible: false
modifier: MODEL1310110042#
type: Reaction
name: Beta-galactoside alpha-2,3-sialyltransferase
product: MODEL1310110042#
is described by: ECO:0000000
fast: false
is version of: http://identifiers.org/ec-code/2.4.99.8

metaR ADRNt
is described by: ECO:0000000
fast: false
reactant: MODEL1310110042#
reversible: true
name: fatty acid transport via diffusion
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11788354,PMID:12864740 NOTES:NJ
is: SBO:0000185
kinetic law: MODEL1310110042#
product: MODEL1310110042#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110042#_98b60f9d_8204_4c00_9a3d_479c98ea2517
is: SBO:0000252
has only substance units: false
is: B2RD24
name: MTHFD1L
type: Species
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:25902
constant: false
boundary condition: true

metaM ksi pre28 g
notes: FORMULA: C213H341N15O176S8X CHARGE: -9
type: Species
name: keratan sulfate I biosynthesis, precursor 28
boundary condition: false
initial amount: NaN
is: SBO:0000247
is: C00130
has only substance units: false
constant: false
is: HMDB00175
is: CHEBI:58053
initial concentration: 1.0

metaR 2HCO3 NAt
fast: false
notes: GENE_ASSOCIATION: (57835.3) or (8671.1) or (57835.2) or (57835.1) or (57835.4) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14722772 NOTES:MM
reversible: true
modifier: MODEL1310110042#
type: Reaction
is described by: ECO:0000269
name: bicarbonate transport (Na/HCO3 1:2 cotransport)
kinetic law: MODEL1310110042#
product: MODEL1310110042#
reactant: MODEL1310110042#
is: SBO:0000185

metaM HC01361 e
is: SBO:0000247
is: CHEBI:17001
notes: FORMULA: C9H13N5O4 CHARGE: 0 INCHI: InChI=1S/C9H13N5O4/c10-9-13-7-5(8(18)14-9)12-3(1-11-7)6(17)4(16)2-15/h4,6,15-17H,1-2H2,(H4,10,11,13,14,18)/t4-,6+/m1/s1 EHMN_ABBREVIATION: C04874
type: Species
name: Dihydroneopterin
constant: false
has only substance units: false
boundary condition: false
initial concentration: 1.0
initial amount: NaN

metaM pail45p hs n
is: SBO:0000247
type: Species
notes: FORMULA: C9H14O15P3FULLRCO2FULLR2CO2 CHARGE: -5 EHMN_ABBREVIATION: C04637
has only substance units: false
initial concentration: 1.0
boundary condition: false
constant: false
name: phosphatidylinositol 4,5-bisphosphate
initial amount: NaN
is: CHEBI:28910

metaR EX fad LPAREN e RPAREN
kinetic law: MODEL1310110042#
reactant: MODEL1310110042#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of Flavin adenine dinucleotide oxidized
type: Reaction

metaR BDMT U
is version of: http://identifiers.org/ec-code/2.4.1.142
modifier: MODEL1310110042#
is: SBO:0000176
product: MODEL1310110042#
name: GDPmannose:chitobiosyldiphosphodolichol beta-D-mannosyltransferase (uterus)
kinetic law: MODEL1310110042#
notes: GENE_ASSOCIATION: (56052.1) SUBSYSTEM: N-glycan synthesis EC Number: 2.4.1.142 Confidence Level: 0 AUTHORS: NOTES:NCD
reactant: MODEL1310110042#
is described by: ECO:0000000
fast: false
type: Reaction
reversible: false

metaR UAG4E
reactant: MODEL1310110042#
type: Reaction
fast: false
reversible: true
is described by: ECO:0000304
kinetic law: MODEL1310110042#
product: MODEL1310110042#
name: UDP-N-acetylglucosamine 4-epimerase
modifier: MODEL1310110042#
notes: GENE_ASSOCIATION: (2582.1) or (2582.2) SUBSYSTEM: Aminosugar metabolism EC Number: 5.1.3.7 Confidence Level: 2 AUTHORS: NOTES:NCD
is version of: http://identifiers.org/ec-code/5.1.3.2
is: SBO:0000176

metaR 3DPHBH1
notes: GENE_ASSOCIATION: SUBSYSTEM: Ubiquinone synthesis EC Number: Confidence Level: 2 AUTHORS: PMID:11051212 NOTES:Used to make Ubiquinone-10 enzyme has not been identified yet. IT
name: Hydroxylation of 3-Decaprenyl-4-hydroxybenzoate (NADH)
reactant: MODEL1310110042#
fast: false
is described by: ECO:0000000
product: MODEL1310110042#
type: Reaction
kinetic law: MODEL1310110042#
is: SBO:0000176
reversible: false

metaR 34DHPLACOX NADP
is version of: http://identifiers.org/ec-code/1.2.1.5
kinetic law: MODEL1310110042#
modifier: MODEL1310110042#
name: 3,4-Dihydroxyphenylacetaldehyde:NADP+ oxidoreductase
is: SBO:0000176
notes: GENE_ASSOCIATION: (222.1) or (221.1) or (218.1) SUBSYSTEM: Tyrosine metabolism EC Number: 1.2.1.5 Confidence Level: 4 AUTHORS: PMID:11306106,PMID:2071588 NOTES:SAB
reversible: true
fast: false
is described by: ECO:0000269
reactant: MODEL1310110042#
type: Reaction
product: MODEL1310110042#

metaM dcacoa m
is: SBO:0000247
initial amount: NaN
is: CHEBI:61430
is: C05274
notes: FORMULA: C31H50N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC01413 EHMN_ABBREVIATION: C05274
boundary condition: false
is: HMDB06404
type: Species
name: Decanoyl-CoA (n-C10:0CoA)
has only substance units: false
initial concentration: 1.0
constant: false

metaM 5oxpro c
is: CHEBI:57606
is: SBO:0000247
name: 5-oxoprolinate
notes: FORMULA: C5H6NO3 CHARGE: -1 INCHI: InChI=1S/C5H7NO3/c7-4-2-1-3(6-4)5(8)9/h3H,1-2H2,(H,6,7)(H,8,9)/p-1 HEPATONET_1.0_ABBREVIATION: HC00856 EHMN_ABBREVIATION: C01879
initial amount: NaN
type: Species
boundary condition: false
is: HMDB00267
initial concentration: 1.0
has only substance units: false
constant: false

metaR GLRASE
fast: false
type: Reaction
product: MODEL1310110042#
is described by: ECO:0000000
kinetic law: MODEL1310110042#
name: glucuronolactone reductase
reactant: MODEL1310110042#
notes: GENE_ASSOCIATION: SUBSYSTEM: Vitamin C metabolism EC Number: 1.1.1.20 Confidence Level: 1 AUTHORS: NOTES:NCD
reversible: true
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110042#_198527b3_fda3_4ef6_8648_0cf930023220
has only substance units: false
initial concentration: NaN
is: SBO:0000252
boundary condition: true
is encoded by: hsa:5152
initial amount: NaN
name: PDE9A
type: Species
constant: false

metaR r2525
is: SBO:0000185
name: Major Facilitator(MFS) TCDB:2.A.1.44.1
reactant: MODEL1310110042#
is described by: ECO:0000000
reversible: true
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:10049700,PMID:10574970,PMID:11389679,PMID:11557028,PMID:11564694,PMID:12824232,PMID:12930836,PMID:14574404,PMID:16288981,PMID:911815 NOTES:
kinetic law: MODEL1310110042#
product: MODEL1310110042#
type: Reaction

metaM glyc c
initial amount: NaN
boundary condition: false
is: SBO:0000247
is: HMDB00131
is: C00116
initial concentration: 1.0
type: Species
is: CHEBI:17754
notes: FORMULA: C3H8O3 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00114 EHMN_ABBREVIATION: C00116
has only substance units: false
name: Glycerol
constant: false

http://identifiers.org/biomodels.db/MODEL1310110042#_18141371_c460_4226_b153_46ee4c678c5d
boundary condition: true
has only substance units: false
is: Q16134
initial amount: NaN
name: ETFDH
initial concentration: NaN
is encoded by: hsa:2110
is: SBO:0000252
constant: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110042#_64321238_04a5_45c6_9ba6_9628397e0a6f
is: SBO:0000252
has only substance units: false
is encoded by: hsa:137872
name: ADHFE1
constant: false
initial amount: NaN
type: Species
boundary condition: true
is: Q8IWW8
initial concentration: NaN

metaR NDPK5n
modifier: MODEL1310110042#
type: Reaction
product: MODEL1310110042#
notes: GENE_ASSOCIATION: (4831.1 and 4830.1) or (4830.2 and 4831.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.6 Confidence Level: 4 AUTHORS: PMID:7050910 NOTES:Many nucleoside diphosphates (eight described) can act as acceptors. While many ribo- and deoxyribonucleoside triphosphates can act as donors, only ATP is chosen as a donor to minimize the number of total reactions.. Presence in the nucleus
kinetic law: MODEL1310110042#
reactant: MODEL1310110042#
is described by: ECO:0000304
fast: false
is version of: http://identifiers.org/ec-code/2.7.4.6
name: nucleoside-diphosphate kinase (ATP:dGDP), nuclear
reversible: true
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110042#_64cf3806_a15e_42a1_82a1_4585013dc359
boundary condition: true
is: Q6IBB3
is encoded by: hsa:9551
initial amount: NaN
type: Species
has only substance units: false
initial concentration: NaN
constant: false
name: ATP5J2
is: SBO:0000252

metaR FACOAL226
reactant: MODEL1310110042#
reversible: true
name: fatty-acid--CoA ligase
product: MODEL1310110042#
type: Reaction
modifier: MODEL1310110042#
notes: GENE_ASSOCIATION: (2180.1) SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 4 AUTHORS: PMID:15292367 NOTES:NJ
fast: false
is: SBO:0000176
kinetic law: MODEL1310110042#
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/6.2.1.3

metaR r2526
type: Reaction
fast: false
is described by: ECO:0000000
is: SBO:0000185
name: Major Facilitator(MFS) TCDB:2.A.1.44.1
product: MODEL1310110042#
kinetic law: MODEL1310110042#
reversible: true
reactant: MODEL1310110042#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:10049700,PMID:10574970,PMID:11389679,PMID:11557028,PMID:11564694,PMID:12824232,PMID:12930836,PMID:14574404,PMID:16288981,PMID:911815 NOTES:

metaR EX strch2 LPAREN e RPAREN
kinetic law: MODEL1310110042#
reactant: MODEL1310110042#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for starch, structure 2 (1,6-{2[1,4-Glc], [1,4-Glc]})
type: Reaction

metaM dhcholestanate c
constant: false
has only substance units: false
is: HMDB00359
is: SBO:0000247
initial amount: NaN
is: CHEBI:16577
boundary condition: false
name: 3alpha,7alpha-Dihydroxy-5beta-cholestanate
notes: FORMULA: C27H45O4 CHARGE: -1 INCHI: InChI=1S/C27H46O4/c1-16(6-5-7-17(2)25(30)31)20-8-9-21-24-22(11-13-27(20,21)4)26(3)12-10-19(28)14-18(26)15-23(24)29/h16-24,28-29H,5-15H2,1-4H3,(H,30,31)/t16-,17?,18+,19-,20-,21+,22+,23-,24+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01313 EHMN_ABBREVIATION: C04554
type: Species
initial concentration: 1.0

metaR CO2t
kinetic law: MODEL1310110042#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 1 AUTHORS: NOTES:tv renamed from CO2TPr to CO2t NCD
reactant: MODEL1310110042#
product: MODEL1310110042#
is described by: ECO:0000000
name: CO2 transporter via diffusion
type: Reaction
is: SBO:0000185
reversible: true
fast: false

http://identifiers.org/biomodels.db/MODEL1310110042#_332c9552_6d06_4093_be9e_75c523d4f709
is encoded by: hsa:6561
type: Species
constant: false
initial amount: NaN
is: SBO:0000252
initial concentration: NaN
name: SLC13A1
boundary condition: true
is: Q9BZW2
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110042#_5aba3ae5_4560_47eb_9289_e82d1b2d8384
is: SBO:0000252
boundary condition: true
has only substance units: false
is encoded by: hsa:8659
is: P30038
initial amount: NaN
constant: false
initial concentration: NaN
type: Species
name: ALDH4A1

metaR BTND1n
name: biotinidase (biotin), nuclear
product: MODEL1310110042#
is version of: http://identifiers.org/ec-code/3.5.1.12
fast: false
reversible: false
modifier: MODEL1310110042#
is described by: ECO:0000269
reactant: MODEL1310110042#
type: Reaction
is: SBO:0000176
notes: GENE_ASSOCIATION: (686.1) SUBSYSTEM: Biotin metabolism EC Number: 3.5.1.12 Confidence Level: 4 AUTHORS: PMID:16011464,PMID:5867120,PMID:7758201,PMID:8593541 NOTES:IT
kinetic law: MODEL1310110042#

metaM bilglcur c
constant: false
has only substance units: false
name: mono(glucosyluronic acid)bilirubin(2-)
boundary condition: false
initial concentration: 1.0
is: SBO:0000247
is: CHEBI:57767
type: Species
notes: FORMULA: C39H44N4O12 CHARGE: 0 INCHI: InChI=1S/C39H44N4O12/c1-7-20-19(6)36(50)43-27(20)14-25-18(5)23(10-12-31(46)54-39-34(49)32(47)33(48)35(55-39)38(52)53)29(41-25)15-28-22(9-11-30(44)45)17(4)24(40-28)13-26-16(3)21(8-2)37(51)42-26/h7-8,13-14,32-35,39-41,47-49H,1-2,9-12,15H2,3-6H3,(H,42,51)(H,43,50)(H,44,45)(H,52,53)/p-2/b26-13+,27-14+/t32-,33-,34+,35-,39+/m0/s1 EHMN_ABBREVIATION: C03374
initial amount: NaN

metaR FACOAL224
is described by: ECO:0000000
reversible: true
type: Reaction
is version of: http://identifiers.org/ec-code/6.2.1.3
kinetic law: MODEL1310110042#
fast: false
product: MODEL1310110042#
notes: GENE_ASSOCIATION: (2180.1) SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 4 AUTHORS: PMID:15292367 NOTES:NJ
reactant: MODEL1310110042#
name: fatty-acid--CoA ligase
is: SBO:0000176
modifier: MODEL1310110042#

http://identifiers.org/biomodels.db/MODEL1310110042#_07afabe9_aebf_457f_8b95_e836b3b6ce02
boundary condition: true
type: Species
has only substance units: false
initial concentration: NaN
is encoded by: hsa:23236
initial amount: NaN
name: PLCB1
constant: false
is: SBO:0000252

metaR EX lneldc LPAREN e RPAREN
kinetic law: MODEL1310110042#
reactant: MODEL1310110042#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: linoelaidic acid exchange
type: Reaction

metaR HSD17B42x
kinetic law: MODEL1310110042#
modifier: MODEL1310110042#
is version of: http://identifiers.org/ec-code/4.2.1.107
product: MODEL1310110042#
is described by: ECO:0000269
name: hydroxysteroid (17-beta) dehydrogenase 4
is: SBO:0000176
fast: false
reactant: MODEL1310110042#
type: Reaction
reversible: false
notes: GENE_ASSOCIATION: (3295.1) SUBSYSTEM: Bile acid synthesis EC Number: Confidence Level: 4 AUTHORS: NOTES:see Russell bile acid synthesis review paper in human recon citation db adamanski et al Steroids (1997) 62:159 notes cofactor NADP/NADPH use

metaR PRPPS
is: SBO:0000176
modifier: MODEL1310110042#
fast: false
product: MODEL1310110042#
reversible: true
is version of: http://identifiers.org/ec-code/2.7.6.1
notes: GENE_ASSOCIATION: (221823.2) or (5631.1) or (221823.1) or (5634.1) SUBSYSTEM: Pentose phosphate pathway EC Number: Confidence Level: 0 AUTHORS: NOTES:
type: Reaction
reactant: MODEL1310110042#
name: phosphoribosylpyrophosphate synthetase
kinetic law: MODEL1310110042#
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110042#_d15aae83_e554_4e90_a13c_f82fd1a5fdf6
has only substance units: false
is: SBO:0000252
is encoded by: hsa:5052
boundary condition: true
name: PRDX1
constant: false
initial amount: NaN
initial concentration: NaN
is: Q06830
type: Species

http://identifiers.org/biomodels.db/MODEL1310110042#_060b8bd4_8e64_4458_a318_ae5a6a5d06a7
is encoded by: hsa:8897
is: SBO:0000252
name: MTMR3
initial amount: NaN
type: Species
initial concentration: NaN
constant: false
has only substance units: false
boundary condition: true

metaR NACHEXA21ly
reactant: MODEL1310110042#
type: Reaction
modifier: MODEL1310110042#
notes: GENE_ASSOCIATION: (3073.1) or (3073.1 and 3074.1) SUBSYSTEM: Keratan sulfate degradation EC Number: Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12706724,PMID:8993162 NOTES:Note that this reaction is specific to beta-N-acetylhexosaminidase A and cannot be catalyzed by beta-N-acetylhexosaminidase B (or presumably beta-N-acetylhexosaminidase S). This is also a lumped reaction, representing the cleavage of GalNAc4S or GalNAc6S and N-acetylgalactosamine 4-sulfatase or 6-sulfatase. NCD
name: beta-N-acetylhexosaminidase A, lysosomal
fast: false
product: MODEL1310110042#
is described by: ECO:0000000
reversible: false
is version of: http://identifiers.org/ec-code/3.2.1.52
kinetic law: MODEL1310110042#
is: SBO:0000176

metaR GULN3D
is described by: ECO:0000000
kinetic law: MODEL1310110042#
name: L-gulonate 3-dehydrogenase
notes: GENE_ASSOCIATION: SUBSYSTEM: Pentose phosphate pathway EC Number: 1.1.1.45 Confidence Level: 2 AUTHORS: PMID:6821187 NOTES:NCD
is: SBO:0000176
reversible: true
fast: false
product: MODEL1310110042#
reactant: MODEL1310110042#
type: Reaction

metaR r1148
type: Reaction
reactant: MODEL1310110042#
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:16919238,PMID:17173541,PMID:18406340,PMID:8132483 NOTES:
kinetic law: MODEL1310110042#
fast: false
is: SBO:0000185
product: MODEL1310110042#
name: Active transport
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110042#_472bbc6e_8c6a_449a_8976_86a3f625092e
initial concentration: NaN
boundary condition: true
initial amount: NaN
is: Q96P26
is: SBO:0000252
name: NT5C1B
type: Species
constant: false
is encoded by: hsa:93034
has only substance units: false

metaM CE5867 e
is: SBO:0000247
initial amount: NaN
type: Species
boundary condition: false
initial concentration: 1.0
notes: FORMULA: C20H32N5O9 CHARGE: -1 INCHI: InChI=1/C20H33N5O9/c1-11(27)22-14(10-26)18(31)24-13(9-16(28)29)17(30)23-12(5-2-3-7-21)19(32)25-8-4-6-15(25)20(33)34/h12-15,26H,2-10,21H2,1H3,(H,22,27)(H,23,30)(H,24,31)(H,28,29)(H,33,34)/p-1/t12-,13+,14-,15-/m0/s1 EHMN_ABBREVIATION: CE5867
name: N-acetyl-seryl-aspartyl-lysyl-proline
has only substance units: false
constant: false
is: HMDB02710
is: CHEBI:27485

metaR r2357
product: MODEL1310110042#
kinetic law: MODEL1310110042#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
fast: false
type: Reaction
name: Organic anion transporter 5 Utilized transport
reversible: true
reactant: MODEL1310110042#
is: SBO:0000185
is described by: ECO:0000000

metaM clpndcoa c
is: SBO:0000247
type: Species
initial amount: NaN
has only substance units: false
notes: FORMULA: C43H64N7O17P3S CHARGE: -4 INCHI: InChI=1/C43H68N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-34(52)71-27-26-45-33(51)24-25-46-41(55)38(54)43(2,3)29-64-70(61,62)67-69(59,60)63-28-32-37(66-68(56,57)58)36(53)42(65-32)50-31-49-35-39(44)47-30-48-40(35)50/h5-6,8-9,11-12,14-15,17-18,30-32,36-38,42,53-54H,4,7,10,13,16,19-29H2,1-3H3,(H,45,51)(H,46,55)(H,59,60)(H,61,62)(H2,44,47,48)(H2,56,57,58)/p-4/b6-5-,9-8-,12-11-,15-14-,18-17-/t32-,36+,37+,38?,42-/m0/s1
initial concentration: 1.0
is: HMDB06267
name: clupanodonyl CoA
is: C16166
boundary condition: false
is: http://identifiers.org/pubchem.compound/47205476
constant: false

http://identifiers.org/biomodels.db/MODEL1310110042#_4cbf6462_d4c7_4599_92f3_bc86efc4765b
boundary condition: true
has only substance units: false
initial concentration: NaN
type: Species
initial amount: NaN
name: GLUD2
is encoded by: hsa:2747
is: P49448
constant: false
is: SBO:0000252

metaR PTDCACRNCPT2
reversible: false
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/2.3.1.21
type: Reaction
fast: false
is: SBO:0000176
notes: GENE_ASSOCIATION: (1376.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: PMID:11274214,PMID:1528846,PMID:1988962 NOTES:NJ
reactant: MODEL1310110042#
product: MODEL1310110042#
kinetic law: MODEL1310110042#
name: pentadecanoate transport into the mitochondria
modifier: MODEL1310110042#

metaR LTA4H
notes: GENE_ASSOCIATION: (4048.1) SUBSYSTEM: Eicosanoid metabolism EC Number: 3.3.2.6 Confidence Level: 4 AUTHORS: PMID:7918238 NOTES:NJ
product: MODEL1310110042#
name: Leukotriene A-4 hydrolase
kinetic law: MODEL1310110042#
reactant: MODEL1310110042#
modifier: MODEL1310110042#
reversible: false
is described by: ECO:0000134
is: SBO:0000176
fast: false
is version of: http://identifiers.org/ec-code/3.3.2.6
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110042#_17f40796_d285_4d39_aed5_074878a46d27
initial amount: NaN
type: Species
initial concentration: NaN
has only substance units: false
is encoded by: hsa:2629
boundary condition: true
constant: false
name: GBA
is: SBO:0000252
is: B7Z6S1

http://identifiers.org/biomodels.db/MODEL1310110042#_a365d4c8_8c64_4ae9_9eb0_3573f9e4fbcc
is: SBO:0000252
type: Species
name: HAO2
initial amount: NaN
has only substance units: false
initial concentration: NaN
is encoded by: hsa:51179
constant: false
is: Q9NYQ3
boundary condition: true

metaR r0726
is version of: http://identifiers.org/ec-code/2.7.1.33
kinetic law: MODEL1310110042#
name: (S)-Hydroxydecanoyl-CoA:NAD+ oxidoreductase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:1.1.1.35 EC:1.1.1.211
reversible: true
type: Reaction
notes: GENE_ASSOCIATION: (AI924226.1) or (53354.1) or (80025.1) or (79646.1) or (55229.1) or (100128062.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.1.1.35 Confidence Level: 0 AUTHORS: PMID:10231530,PMID:10329704,PMID:1550553,PMID:1651711,PMID:7150615,PMID:8188243,PMID:8687463,PMID:9553139 NOTES:
product: MODEL1310110042#
is described by: ECO:0000000
modifier: MODEL1310110042#
reactant: MODEL1310110042#
fast: false
is: SBO:0000176

metaR RE1448N
type: Reaction
reversible: true
is described by: ECO:0000000
reactant: MODEL1310110042#
product: MODEL1310110042#
fast: false
is: SBO:0000176
name: RE1448
notes: GENE_ASSOCIATION: SUBSYSTEM: Phosphatidylinositol phosphate metabolism EC Number: 3.1.3.67 Confidence Level: 0 AUTHORS: PMID:7556092,PMID:9367831 NOTES:
kinetic law: MODEL1310110042#

metaR r2020
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reactant: MODEL1310110042#
modifier: MODEL1310110042#
fast: false
kinetic law: MODEL1310110042#
reversible: false
is described by: ECO:0000000
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.15
type: Reaction
product: MODEL1310110042#
is: SBO:0000185

metaM glyc e
has only substance units: false
notes: FORMULA: C3H8O3 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00114 EHMN_ABBREVIATION: C00116
boundary condition: false
is: C00116
constant: false
is: HMDB00131
is: CHEBI:17754
initial amount: NaN
type: Species
initial concentration: 1.0
is: SBO:0000247
name: Glycerol

http://identifiers.org/biomodels.db/MODEL1310110042#_f8c668b8_99b4_448d_8342_873c3a55cf6a
type: Species
name: PIGC
constant: false
is encoded by: hsa:5279
is: SBO:0000252
boundary condition: true
initial amount: NaN
initial concentration: NaN
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110042#_24487c7f_3fd6_47e8_932c_1d0648e0a521
initial concentration: NaN
name: NT5E
type: Species
boundary condition: true
initial amount: NaN
is: P21589
constant: false
has only substance units: false
is encoded by: hsa:4907
is: SBO:0000252

metaR r2131
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
reversible: true
is: SBO:0000185
kinetic law: MODEL1310110042#
product: MODEL1310110042#
fast: false
is described by: ECO:0000000
modifier: MODEL1310110042#
reactant: MODEL1310110042#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110042#_12157a54_01d8_44bf_a1c5_58fdfb85b27a
is: SBO:0000252
has only substance units: false
name: ACADM
type: Species
is: P11310
is encoded by: hsa:34
initial concentration: NaN
boundary condition: true
initial amount: NaN
constant: false

metaR r2356
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
reversible: true
product: MODEL1310110042#
type: Reaction
kinetic law: MODEL1310110042#
name: Organic anion transporter 5 Utilized transport
is described by: ECO:0000000
fast: false
reactant: MODEL1310110042#
is: SBO:0000185

metaM uacgam g
is: HMDB00290
initial amount: NaN
initial concentration: 1.0
has only substance units: false
name: UDP-N-acetyl-alpha-D-glucosamine(2-)
is: CHEBI:57705
boundary condition: false
notes: FORMULA: C17H25N3O17P2 CHARGE: -2 INCHI: InChI=1S/C17H27N3O17P2/c1-6(22)18-10-13(26)11(24)7(4-21)35-16(10)36-39(31,32)37-38(29,30)33-5-8-12(25)14(27)15(34-8)20-3-2-9(23)19-17(20)28/h2-3,7-8,10-16,21,24-27H,4-5H2,1H3,(H,18,22)(H,29,30)(H,31,32)(H,19,23,28)/p-2/t7-,8-,10-,11-,12-,13-,14-,15-,16-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00050 EHMN_ABBREVIATION: C00043
type: Species
is: SBO:0000247
constant: false

http://identifiers.org/biomodels.db/MODEL1310110042#_fc9fe1b6_ca5c_4ed7_a69b_a159cea1d576
is: SBO:0000252
has only substance units: false
type: Species
initial concentration: NaN
boundary condition: true
constant: false
is: Q99624
initial amount: NaN
is encoded by: hsa:10991
name: SLC38A3

metaR PTDCACRNCPT1
name: carnitine fatty-acyl transferase
modifier: MODEL1310110042#
fast: false
is described by: ECO:0000269
reactant: MODEL1310110042#
product: MODEL1310110042#
kinetic law: MODEL1310110042#
notes: GENE_ASSOCIATION: (1375.1) or (1375.4) or (1375.3) or (1374.1) or (126129.1) or (1375.2) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.21 Confidence Level: 4 AUTHORS: PMID:1988962 NOTES:NJ
reversible: false
type: Reaction
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.3.1.21

metaR THMP
name: thiamin phosphatase
fast: false
type: Reaction
is described by: ECO:0000000
is: SBO:0000176
product: MODEL1310110042#
reactant: MODEL1310110042#
reversible: false
kinetic law: MODEL1310110042#
notes: GENE_ASSOCIATION: SUBSYSTEM: Thiamine metabolism EC Number: Confidence Level: 1 AUTHORS: PMID:11997266,PMID:8522961 NOTES:EC 3.1.3.- NCD

metaR r0321
modifier: MODEL1310110042#
product: MODEL1310110042#
reactant: MODEL1310110042#
fast: false
name: Acetoacetate:CoA ligase (AMP-forming) Butanoate metabolism EC:6.2.1.16
reversible: false
kinetic law: MODEL1310110042#
is version of: http://identifiers.org/ec-code/6.3.5.2
notes: GENE_ASSOCIATION: (AA664770.1) or (AI684467.1) or (8833.1) SUBSYSTEM: Cholesterol metabolism EC Number: 6.2.1.16 Confidence Level: 0 AUTHORS: PMID:4073493 NOTES:
is described by: ECO:0000000
is: SBO:0000176
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110042#_3fff1009_333d_4914_8ca6_a48fcdf74709
constant: false
is: E9PDK1
boundary condition: true
initial concentration: NaN
type: Species
has only substance units: false
name: SLC4A9
initial amount: NaN
is: SBO:0000252
is encoded by: hsa:83697

http://identifiers.org/biomodels.db/MODEL1310110042#_58658210_e445_4c6d_b6d6_951aa35afdb2
initial amount: NaN
constant: false
is: P46459
boundary condition: true
is: SBO:0000252
name: NSF
type: Species
has only substance units: false
is encoded by: hsa:4905
initial concentration: NaN

metaM dectricoa m
name: 2,4,7-decatrienoylcoa
is: http://identifiers.org/pubchem.compound/16019966
is: SBO:0000247
has only substance units: false
initial amount: NaN
notes: FORMULA: C31H44N7O17P3S CHARGE: -4
initial concentration: 1.0
boundary condition: false
type: Species
constant: false

http://identifiers.org/biomodels.db/MODEL1310110042#_ca43d6b4_5b91_4184_bcf4_4a52041ba572
boundary condition: true
constant: false
is encoded by: hsa:5198
is: Q6P4B4
type: Species
initial amount: NaN
initial concentration: NaN
name: PFAS
has only substance units: false
is: SBO:0000252

metaR r0727
type: Reaction
reactant: MODEL1310110042#
fast: false
is described by: ECO:0000000
kinetic law: MODEL1310110042#
name: (S)-Hydroxydecanoyl-CoA:NAD+ oxidoreductase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:1.1.1.211 EC:1.1.1.35
product: MODEL1310110042#
is: SBO:0000176
reversible: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: 1.1.1.35 Confidence Level: 0 AUTHORS: PMID:10231530,PMID:10329704,PMID:1550553,PMID:1651711,PMID:7150615,PMID:8188243,PMID:8687463,PMID:9553139 NOTES:

metaM lnlccoa r
notes: FORMULA: C39H62N7O17P3S CHARGE: -4 INCHI: InChI=1/C39H66N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-30(48)67-23-22-41-29(47)20-21-42-37(51)34(50)39(2,3)25-60-66(57,58)63-65(55,56)59-24-28-33(62-64(52,53)54)32(49)38(61-28)46-27-45-31-35(40)43-26-44-36(31)46/h8-9,11-12,26-28,32-34,38,49-50H,4-7,10,13-25H2,1-3H3,(H,41,47)(H,42,51)(H,55,56)(H,57,58)(H2,40,43,44)(H2,52,53,54)/b9-8+,12-11+ HEPATONET_1.0_ABBREVIATION: HC01983
is: SBO:0000247
is: HMDB01064
boundary condition: false
is: http://identifiers.org/pubchem.compound/5462164
has only substance units: false
constant: false
type: Species
initial concentration: 1.0
initial amount: NaN
name: linoleic coenzyme A

metaM arachcoa m
notes: FORMULA: C41H70N7O17P3S CHARGE: -4 INCHI: InChI=1S/C41H74N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-32(50)69-25-24-43-31(49)22-23-44-39(53)36(52)41(2,3)27-62-68(59,60)65-67(57,58)61-26-30-35(64-66(54,55)56)34(51)40(63-30)48-29-47-33-37(42)45-28-46-38(33)48/h28-30,34-36,40,51-52H,4-27H2,1-3H3,(H,43,49)(H,44,53)(H,57,58)(H,59,60)(H2,42,45,46)(H2,54,55,56)/t30-,34-,35-,36+,40-/m1/s1 EHMN_ABBREVIATION: C02041
initial amount: NaN
is: HMDB04258
name: arachidyl coenzyme A
boundary condition: false
has only substance units: false
type: Species
is: SBO:0000247
initial concentration: 1.0
constant: false
is: CHEBI:15527

metaR M13N2Tg
notes: GENE_ASSOCIATION: (4245.1) SUBSYSTEM: N-glycan synthesis EC Number: 2.4.1.101 Confidence Level: 0 AUTHORS: PMID:12621063 NOTES:NCD
name: alpha-1,3-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase
modifier: MODEL1310110042#
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/2.4.1.101
is: SBO:0000176
type: Reaction
reactant: MODEL1310110042#
reversible: false
product: MODEL1310110042#
kinetic law: MODEL1310110042#
fast: false

http://identifiers.org/biomodels.db/MODEL1310110042#_aa967afd_bae3_488d_a745_468216bbb23c
has only substance units: false
type: Species
initial concentration: NaN
boundary condition: true
initial amount: NaN
constant: false
is encoded by: hsa:7296
name: TXNRD1
is: SBO:0000252

metaM sbt D e
is: HMDB00247
constant: false
name: D-glucitol
initial amount: NaN
type: Species
is: SBO:0000247
has only substance units: false
boundary condition: false
initial concentration: 1.0
notes: FORMULA: C6H14O6 CHARGE: 0 INCHI: InChI=1S/C6H14O6/c7-1-3(9)5(11)6(12)4(10)2-8/h3-12H,1-2H2/t3-,4+,5-,6-/m1/s1

metaR r2130
reversible: true
modifier: MODEL1310110042#
fast: false
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
product: MODEL1310110042#
reactant: MODEL1310110042#
is: SBO:0000185
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
type: Reaction
kinetic law: MODEL1310110042#

http://identifiers.org/biomodels.db/MODEL1310110042#_d5367e09_af26_4321_8219_ac79f3e2c1d2
is: Q8IUC8
has only substance units: false
name: GALNT13
initial concentration: NaN
is: SBO:0000252
initial amount: NaN
boundary condition: true
type: Species
is encoded by: hsa:114805
constant: false

metaR TMDPK
kinetic law: MODEL1310110042#
is version of: http://identifiers.org/ec-code/2.7.6.2
product: MODEL1310110042#
name: Thiamin pyrophosphokinase (EC 2.7.6.2)
reactant: MODEL1310110042#
modifier: MODEL1310110042#
is: SBO:0000176
type: Reaction
reversible: false
notes: GENE_ASSOCIATION: (27010.1) SUBSYSTEM: Thiamine metabolism EC Number: Confidence Level: 4 AUTHORS: NOTES:
is described by: ECO:0000269
fast: false

http://identifiers.org/biomodels.db/MODEL1310110042#_4fb034e0_4604_4009_b526_4a526dcd9998
has part: P55084
is encoded by: hsa:3032
boundary condition: true
name: HADHA:HADHB
has only substance units: false
initial concentration: NaN
constant: false
type: Species
has part: E9KL44
initial amount: NaN
is encoded by: hsa:3030
is: SBO:0000297

metaR r2355
product: MODEL1310110042#
kinetic law: MODEL1310110042#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
name: Organic anion transporter 5 Utilized transport
fast: false
reversible: true
type: Reaction
reactant: MODEL1310110042#
is: SBO:0000185
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110042#_cd68fd67_ceda_4d5b_a51d_72487eae4a08
initial amount: NaN
boundary condition: true
constant: false
type: Species
is: SBO:0000252
initial concentration: NaN
is: P20594
is encoded by: hsa:4882
name: NPR2
has only substance units: false

metaR EHGLAT2m
is described by: ECO:0000304
product: MODEL1310110042#
is version of: http://identifiers.org/ec-code/2.6.1.1
notes: GENE_ASSOCIATION: (2806.1) SUBSYSTEM: Arginine and Proline Metabolism EC Number: 2.6.1.21 Confidence Level: 2 AUTHORS: PMID:12660328,PMID:15849464 NOTES:NCD SAB oaa -> asp-L
fast: false
name: L-erythro-4-Hydroxyglutamate:2-oxoglutarate aminotransferase 2, mitochondrial
is: SBO:0000176
modifier: MODEL1310110042#
kinetic law: MODEL1310110042#
reversible: false
reactant: MODEL1310110042#
type: Reaction

metaR AHCYStd
is described by: ECO:0000134
type: Reaction
reversible: true
kinetic law: MODEL1310110042#
is: SBO:0000185
name: diffusion of S-Adenosyl-L-homocysteine
product: MODEL1310110042#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID: 8283303. NOTES:
fast: false
reactant: MODEL1310110042#

metaM ivcoa m
initial concentration: 1.0
boundary condition: false
name: Isovaleryl-CoA
is: CHEBI:57345
constant: false
initial amount: NaN
notes: FORMULA: C26H40N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC01021 EHMN_ABBREVIATION: C02939
is: HMDB01113
has only substance units: false
is: SBO:0000247
type: Species

http://identifiers.org/biomodels.db/MODEL1310110042#_997f0604_f4c9_42bb_bc52_a33e1233d0a1
type: Species
name: SLC16A1
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:6566
constant: false
is: SBO:0000252
is: B4DKS0
boundary condition: true
has only substance units: false

metaR r0728
reactant: MODEL1310110042#
type: Reaction
fast: false
name: (S)-Hydroxydecanoyl-CoA hydro-lyase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:4.2.1.17
is described by: ECO:0000000
product: MODEL1310110042#
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.17 Confidence Level: 0 AUTHORS: PMID:8012501,PMID:8188243 NOTES:
kinetic law: MODEL1310110042#
is: SBO:0000176
reversible: true

metaR AHEXASEly
type: Reaction
is described by: ECO:0000000
name: beta-N-acetylhexosaminidase, lysosomal
notes: GENE_ASSOCIATION: (3073.1) or (3074.1) or (3073.1 and 3074.1) SUBSYSTEM: N-glycan degradation EC Number: 3.2.1.52 Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12706724 NOTES:NCD
product: MODEL1310110042#
reversible: false
reactant: MODEL1310110042#
is version of: http://identifiers.org/ec-code/3.2.1.52
is: SBO:0000176
modifier: MODEL1310110042#
kinetic law: MODEL1310110042#
fast: false

metaR EX prpp LPAREN e RPAREN
kinetic law: MODEL1310110042#
reactant: MODEL1310110042#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of 5-O-phosphonato-alpha-D-ribofuranosyl diphosphate(5-)
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110042#_770211fc_282b_4a56_b063_84ded0f192e3
name: MOGS
is encoded by: hsa:7841
is: SBO:0000252
boundary condition: true
type: Species
initial amount: NaN
initial concentration: NaN
constant: false
has only substance units: false
is: F5H6D0

metaM pyr m
name: pyruvate
notes: FORMULA: C3H3O3 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00032 EHMN_ABBREVIATION: C00022
is: C00022
constant: false
initial concentration: 1.0
type: Species
is: HMDB00243
boundary condition: false
is: http://identifiers.org/pubchem.compound/3324
is: SBO:0000247
initial amount: NaN
is: CHEBI:15361
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110042#_2186595a_cc36_488b_801c_c1fadd507af1
constant: false
initial concentration: NaN
type: Species
boundary condition: true
initial amount: NaN
has only substance units: false
name: _R51273_1_c
is encoded by: hsa:R51273
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110042#_c2fd6ef9_1633_4831_9e57_d76d6ac8f209
is: P22413
boundary condition: true
type: Species
initial amount: NaN
is encoded by: hsa:5167
has only substance units: false
initial concentration: NaN
is: SBO:0000252
name: ENPP1
constant: false

http://identifiers.org/biomodels.db/MODEL1310110042#_443bc662_bf96_43a1_9329_7713d10a89ed
initial amount: NaN
has only substance units: false
initial concentration: NaN
is encoded by: hsa:3948
is: SBO:0000252
is: P07864
name: LDHC
type: Species
constant: false
boundary condition: true

metaM o2 x
is: CHEBI:15379
initial amount: NaN
initial concentration: 1.0
notes: FORMULA: O2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00017 EHMN_ABBREVIATION: C00007
is: SBO:0000247
is: C00007
type: Species
is: HMDB01377
name: O2
constant: false
has only substance units: false
boundary condition: false

metaM pail45p hs m
name: phosphatidylinositol 4,5-bisphosphate
initial amount: NaN
type: Species
is: CHEBI:28910
has only substance units: false
boundary condition: false
initial concentration: 1.0
constant: false
is: SBO:0000247
notes: FORMULA: C9H14O15P3FULLRCO2FULLR2CO2 CHARGE: -5 EHMN_ABBREVIATION: C04637

metaM udpacgal l
is: CHEBI:57847
constant: false
boundary condition: false
type: Species
initial amount: NaN
has only substance units: false
is: HMDB00304
name: UDP-N-acetyl-D-galactosamine(2-)
notes: FORMULA: C17H25N3O17P2 CHARGE: -2 INCHI: InChI=1S/C17H27N3O17P2/c1-6(22)18-10-13(26)11(24)7(4-21)35-16(10)36-39(31,32)37-38(29,30)33-5-8-12(25)14(27)15(34-8)20-3-2-9(23)19-17(20)28/h2-3,7-8,10-16,21,24-27H,4-5H2,1H3,(H,18,22)(H,29,30)(H,31,32)(H,19,23,28)/p-2/t7-,8-,10-,11+,12-,13-,14-,15-,16?/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00190 EHMN_ABBREVIATION: C00203
initial concentration: 1.0
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110042#_232b9dd6_6b6a_4b26_b073_4b316e460ba3
name: _D87002_1_m
constant: false
initial concentration: NaN
type: Species
is encoded by: hsa:D87002
is: SBO:0000252
boundary condition: true
has only substance units: false
initial amount: NaN

metaR HEXDICOAACBP
kinetic law: MODEL1310110042#
product: MODEL1310110042#
reactant: MODEL1310110042#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: transport of hexadecanedioyl coa
type: Reaction

metaR XYLtly
is: SBO:0000185
name: Xylose efflux from lysosome
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 1 AUTHORS: PMID:1751541,PMID:8993166 NOTES:NCD
reversible: false
kinetic law: MODEL1310110042#
reactant: MODEL1310110042#
product: MODEL1310110042#
is described by: ECO:0000000
type: Reaction
fast: false

metaR G3PD1
reactant: MODEL1310110042#
notes: GENE_ASSOCIATION: (2819.1) SUBSYSTEM: Glycerophospholipid metabolism EC Number: 1.1.1.94 Confidence Level: 4 AUTHORS: PMID:11385633,PMID:7772607 NOTES:NAD-specific; see also G3PD2
name: glycerol-3-phosphate dehydrogenase (NAD)
is described by: ECO:0000269
type: Reaction
fast: false
is version of: http://identifiers.org/ec-code/1.1.1.8
product: MODEL1310110042#
kinetic law: MODEL1310110042#
is: SBO:0000176
reversible: true
modifier: MODEL1310110042#

metaR AHCYSte
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
reversible: true
name: Transport of S-adenosyl-L-homocysteine
product: MODEL1310110042#
type: Reaction
fast: false
kinetic law: MODEL1310110042#
is described by: ECO:0000134
reactant: MODEL1310110042#
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110042#_a11af98a_efd2_4943_8225_b5d540c68d07
is encoded by: hsa:8876
initial amount: NaN
is: SBO:0000297
constant: false
has part: A8K7W0
has part: O95497
initial concentration: NaN
boundary condition: true
is encoded by: hsa:8875
is encoded by: hsa:55350
has only substance units: false
type: Species
name: VNN3:VNN2:VNN1

http://identifiers.org/biomodels.db/MODEL1310110042#_e57e986d_5343_4ddf_9507_b04b46a403bd
boundary condition: true
has only substance units: false
type: Species
constant: false
is: SBO:0000252
is encoded by: hsa:65985
initial concentration: NaN
name: AACS
is: Q86V21
initial amount: NaN

metaR ST8SIA12
type: Reaction
is described by: ECO:0000000
kinetic law: MODEL1310110042#
reactant: MODEL1310110042#
modifier: MODEL1310110042#
product: MODEL1310110042#
notes: GENE_ASSOCIATION: (6489.1) SUBSYSTEM: Sphingolipid metabolism EC Number: 2.4.99.8 Confidence Level: 4 AUTHORS: PMID:9199191 NOTES:NJ
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.4.99.8
fast: false
reversible: false
name: Beta-galactoside alpha-2,3-sialyltransferase

metaR r0729
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.17 Confidence Level: 0 AUTHORS: PMID:8012501,PMID:8188243 NOTES:
is described by: ECO:0000000
kinetic law: MODEL1310110042#
reactant: MODEL1310110042#
fast: false
is: SBO:0000176
reversible: false
product: MODEL1310110042#
type: Reaction
name: (S)-Hydroxydecanoyl-CoA hydro-lyase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:4.2.1.17

http://identifiers.org/biomodels.db/MODEL1310110042#_ae3d93ef_6ef8_4fcf_94be_2171b407102e
is: SBO:0000252
type: Species
is: P24310
boundary condition: true
constant: false
has only substance units: false
name: COX7A1
initial amount: NaN
is encoded by: hsa:1346
initial concentration: NaN

metaM sbt D c
notes: FORMULA: C6H14O6 CHARGE: 0 INCHI: InChI=1S/C6H14O6/c7-1-3(9)5(11)6(12)4(10)2-8/h3-12H,1-2H2/t3-,4+,5-,6-/m1/s1
type: Species
boundary condition: false
is: SBO:0000247
initial amount: NaN
constant: false
is: HMDB00247
name: D-glucitol
is: CHEBI:17924
initial concentration: 1.0
has only substance units: false

metaR ANTHte
reversible: true
reactant: MODEL1310110042#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
product: MODEL1310110042#
kinetic law: MODEL1310110042#
type: Reaction
is: SBO:0000185
fast: false
name: Transport of anthranilate

metaM c8dc c
name: suberyl carnitine
type: Species
constant: false
is: HMDB00791
boundary condition: false
initial amount: NaN
has only substance units: false
initial concentration: 1.0
is: SBO:0000247
notes: FORMULA: C15H26NO6 CHARGE: -1
is: C02838

metaM thexddcoa m
is: SBO:0000247
is: HMDB02288
boundary condition: false
name: trans7,10-hexadecadienoylcoa
type: Species
initial concentration: 1.0
constant: false
has only substance units: false
initial amount: NaN
notes: FORMULA: C37H58N7O17P3S CHARGE: -4

metaR r2354
product: MODEL1310110042#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
name: Organic anion transporter 5 Utilized transport
fast: false
is: SBO:0000185
kinetic law: MODEL1310110042#
reactant: MODEL1310110042#
type: Reaction
is described by: ECO:0000000
reversible: true

metaM htaxol c
is: CHEBI:28815
is: SBO:0000247
constant: false
initial amount: NaN
name: 6 alpha hydroxy taxol/ 6 alpha hydroxy paclitaxel
boundary condition: false
has only substance units: false
initial concentration: 1.0
type: Species
notes: FORMULA: C47H31NO15 CHARGE: 0 INCHI: InChI=1/C47H51NO15/c1-24-30(61-43(57)33(51)32(27-16-10-7-11-17-27)48-41(55)28-18-12-8-13-19-28)22-47(58)40(62-42(56)29-20-14-9-15-21-29)36-45(6,38(54)35(60-25(2)49)31(24)44(47,4)5)37(53)34(52)39-46(36,23-59-39)63-26(3)50/h7-21,30,32-37,39-40,51-53,58H,22-23H2,1-6H3,(H,48,55)/t30-,32-,33+,34-,35+,36-,37-,39+,40-,45+,46-,47-/m1/s1

metaM 2dp6mobq me m
type: Species
name: 2-decaprenyl-6-methoxy-3-methyl-1,4-benzoquinone
notes: FORMULA: C58H88O3 CHARGE: 0 INCHI: InChI=1S/C58H88O3/c1-44(2)23-14-24-45(3)25-15-26-46(4)27-16-28-47(5)29-17-30-48(6)31-18-32-49(7)33-19-34-50(8)35-20-36-51(9)37-21-38-52(10)39-22-40-53(11)41-42-55-54(12)56(59)43-57(61-13)58(55)60/h23,25,27,29,31,33,35,37,39,41,43H,14-22,24,26,28,30,32,34,36,38,40,42H2,1-13H3/b45-25+,46-27+,47-29+,48-31+,49-33+,50-35+,51-37+,52-39+,53-41+
constant: false
initial amount: NaN
has only substance units: false
is: CHEBI:50772
is: SBO:0000247
initial concentration: 1.0
boundary condition: false

metaR EX tdcrn
kinetic law: MODEL1310110042#
reactant: MODEL1310110042#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for myristoyl carnitine
type: Reaction

metaR EX so4 LPAREN e RPAREN
kinetic law: MODEL1310110042#
reactant: MODEL1310110042#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Sulfate exchange
type: Reaction

metaM dolglcp L r
is: SBO:0000247
has only substance units: false
boundary condition: false
name: Dolichyl beta-D-glucosyl phosphate, human liver homolog
is: CHEBI:15812
constant: false
initial concentration: 1.0
notes: FORMULA: C1140H1868O90P10 CHARGE: -10 INCHI: InChI=1S/C31H55O9P/c1-22(2)11-7-12-23(3)13-8-14-24(4)15-9-16-25(5)17-10-18-26(6)19-20-38-41(36,37)40-31-30(35)29(34)28(33)27(21-32)39-31/h11,13,15,17,26-35H,7-10,12,14,16,18-21H2,1-6H3,(H,36,37)/b23-13+,24-15+,25-17-/t26?,27-,28-,29+,30-,31+/m1/s1
initial amount: NaN
type: Species

metaR RE0453C
product: MODEL1310110042#
is: SBO:0000176
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Pyrimidine synthesis EC Number: 2.7.4.6 Confidence Level: 0 AUTHORS: PMID:3026468 NOTES:
is described by: ECO:0000000
kinetic law: MODEL1310110042#
fast: false
reactant: MODEL1310110042#
type: Reaction
name: RE0453

http://identifiers.org/biomodels.db/MODEL1310110042#_e93bcd8a_9b8b_4e42_8ea2_96915a92dedb
initial concentration: NaN
has only substance units: false
is encoded by: hsa:517
initial amount: NaN
is: Q06055
boundary condition: true
is: SBO:0000252
type: Species
name: ATP5G2
constant: false

metaM hdd2crn c
name: trans-Hexadec-2-enoyl carnitine
has only substance units: false
initial amount: NaN
is: SBO:0000247
notes: FORMULA: C23H43NO4 CHARGE: 0 INCHI: InChI=1/C23H43NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-23(27)28-21(19-22(25)26)20-24(2,3)4/h17-18,21H,5-16,19-20H2,1-4H3/b18-17+
boundary condition: false
is: HMDB06317
type: Species
constant: false
initial concentration: 1.0

metaM ura c
is: C00106
has only substance units: false
initial amount: NaN
initial concentration: 1.0
type: Species
name: Uracil
boundary condition: false
is: HMDB00300
is: CHEBI:17568
is: SBO:0000247
notes: FORMULA: C4H4N2O2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00106 EHMN_ABBREVIATION: C00106
constant: false

metaR LEUt4
kinetic law: MODEL1310110042#
type: Reaction
fast: false
product: MODEL1310110042#
name: L-leucine transport in via sodium symport
modifier: MODEL1310110042#
is: SBO:0000185
reversible: false
notes: GENE_ASSOCIATION: (81539.1) or (84889.1) or (6520.1) or (6542.1) or (6541.1) or (11254.1) or (55089.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10391915,PMID:10891391,PMID:11325958,PMID:11342143,PMID:11414754,PMID:11591158,PMID:11891586,PMID:12049641,PMID:1348489,PMID:1376926,PMID:14770310,PMID:7534987,PMID:8954799 NOTES:SAB
is described by: ECO:0000269
reactant: MODEL1310110042#

metaR EX citr L LPAREN e RPAREN
kinetic law: MODEL1310110042#
reactant: MODEL1310110042#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: L-citrulline exchange
type: Reaction

metaR FAOXC184C164m
kinetic law: MODEL1310110042#
product: MODEL1310110042#
reactant: MODEL1310110042#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C18:4-->C16:4)m
type: Reaction

metaR r0055
is described by: ECO:0000000
fast: false
reversible: true
reactant: MODEL1310110042#
notes: GENE_ASSOCIATION: (353.1) or (3251.1) SUBSYSTEM: Pyruvate metabolism EC Number: 1.2.1.49 Confidence Level: 0 AUTHORS: PMID:20958,PMID:4383524,PMID:4391087,PMID:6014,PMID:7107625,PMID:7107626,PMID:7144586,PMID:7763257,PMID:7993370 NOTES:IT added 2 protons (are there really 2 protons produced?)
is version of: http://identifiers.org/ec-code/2.4.2.8
modifier: MODEL1310110042#
is version of: http://identifiers.org/ec-code/2.4.2.7
is: SBO:0000176
name: 2-Oxopropanal:NADP+ oxidoreductase Pyruvate metabolism EC:1.2.1.49
kinetic law: MODEL1310110042#
type: Reaction
product: MODEL1310110042#

http://identifiers.org/biomodels.db/MODEL1310110042#_a5f24ed6_59aa_46af_8678_1ff7d35e2f29
is: SBO:0000252
name: _206_1_c
is encoded by: hsa:206
has only substance units: false
initial concentration: NaN
boundary condition: true
constant: false
initial amount: NaN
type: Species

metaR r0722
is version of: http://identifiers.org/ec-code/4.2.3.12
is: SBO:0000176
notes: GENE_ASSOCIATION: (5805.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.1.1.35 Confidence Level: 0 AUTHORS: PMID:10231530,PMID:10329704,PMID:1550553,PMID:1651711,PMID:7150615,PMID:8188243,PMID:8687463,PMID:9553139 NOTES:
reactant: MODEL1310110042#
modifier: MODEL1310110042#
fast: false
type: Reaction
kinetic law: MODEL1310110042#
is described by: ECO:0000000
reversible: true
name: (S)-3-Hydroxydodecanoyl-CoA:NAD+ oxidoreductase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:1.1.1.35 EC:1.1.1.211
product: MODEL1310110042#

http://identifiers.org/biomodels.db/MODEL1310110042#_5305158a_2c87_454e_9f19_3df648f440d1
constant: false
is encoded by: hsa:1798
initial amount: NaN
name: DPAGT1
initial concentration: NaN
is: SBO:0000252
has only substance units: false
type: Species
boundary condition: true

metaR EX HC01609 LPAREN e RPAREN
kinetic law: MODEL1310110042#
reactant: MODEL1310110042#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of UroporphyrinogenI
type: Reaction

metaR r2024
kinetic law: MODEL1310110042#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.15
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
product: MODEL1310110042#
reversible: false
modifier: MODEL1310110042#
reactant: MODEL1310110042#
is: SBO:0000185
is described by: ECO:0000000
fast: false
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110042#_857924c1_09fe_4a1d_bd12_595a6de69426
initial amount: NaN
is encoded by: hsa:6547
constant: false
name: SLC8A3
is: Q96QG2
boundary condition: true
initial concentration: NaN
type: Species
is: SBO:0000252
has only substance units: false

metaR DOLGLCP Lter
reactant: MODEL1310110042#
product: MODEL1310110042#
notes: GENE_ASSOCIATION: SUBSYSTEM: N-glycan synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:12137737 NOTES:
fast: false
reversible: false
is: SBO:0000185
type: Reaction
is described by: ECO:0000000
kinetic law: MODEL1310110042#
name: Dolichyl beta-D-glucosyl phosphate flippase (liver)

metaR IDPtn
name: IDP nuclear transport
is: SBO:0000185
type: Reaction
reversible: true
product: MODEL1310110042#
fast: false
is described by: ECO:0000000
kinetic law: MODEL1310110042#
reactant: MODEL1310110042#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: NOTES:IT

http://identifiers.org/biomodels.db/MODEL1310110042#_a42b4f7d_37ee_4f45_92e8_87dfc8cc4b76
initial amount: NaN
is: SBO:0000252
boundary condition: true
name: CA13
constant: false
type: Species
is: Q8N1Q1
is encoded by: hsa:377677
has only substance units: false
initial concentration: NaN

metaR UAGDP
modifier: MODEL1310110042#
is: SBO:0000176
reactant: MODEL1310110042#
notes: GENE_ASSOCIATION: (6675.1) or (91373.1) SUBSYSTEM: Aminosugar metabolism EC Number: 2.7.7.23 Confidence Level: 4 AUTHORS: PMID:9603950 NOTES:
kinetic law: MODEL1310110042#
product: MODEL1310110042#
fast: false
is version of: http://identifiers.org/ec-code/2.7.7.23
type: Reaction
is described by: ECO:0000269
name: UDP-N-acetylglucosamine diphosphorylase
reversible: false

metaR HEXCOAACBP
kinetic law: MODEL1310110042#
product: MODEL1310110042#
reactant: MODEL1310110042#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of Hexanoyl-CoA (n-C6:0CoA) from mitochondria into cytosol
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110042#_aa3321dd_9e06_4abc_95b4_030c8ace99f1
boundary condition: true
type: Species
has only substance units: false
name: ELOVL1
is: SBO:0000252
is encoded by: hsa:64834
constant: false
initial amount: NaN
is: Q9BW60
initial concentration: NaN

metaM tetdecdicoa m
notes: FORMULA: C35H54N7O17P3S CHARGE: -4
is: HMDB02288
has only substance units: false
constant: false
is: SBO:0000247
type: Species
initial amount: NaN
name: 5,8-tetradecadienoylcoa
initial concentration: 1.0
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110042#_477d2ef4_be89_4c05_8818_b3f323201d37
boundary condition: true
constant: false
is encoded by: hsa:278
initial concentration: NaN
initial amount: NaN
is: SBO:0000252
has only substance units: false
type: Species
name: AMY1C
is: P04745

metaR BDMT L
reversible: false
notes: GENE_ASSOCIATION: (56052.1) SUBSYSTEM: N-glycan synthesis EC Number: 2.4.1.142 Confidence Level: 0 AUTHORS: NOTES:NCD
is: SBO:0000176
product: MODEL1310110042#
fast: false
modifier: MODEL1310110042#
kinetic law: MODEL1310110042#
type: Reaction
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/2.4.1.142
name: GDPmannose:chitobiosyldiphosphodolichol beta-D-mannosyltransferase (liver)
reactant: MODEL1310110042#

metaM uacgam c
is: HMDB00290
name: UDP-N-acetyl-alpha-D-glucosamine(2-)
notes: FORMULA: C17H25N3O17P2 CHARGE: -2 INCHI: InChI=1S/C17H27N3O17P2/c1-6(22)18-10-13(26)11(24)7(4-21)35-16(10)36-39(31,32)37-38(29,30)33-5-8-12(25)14(27)15(34-8)20-3-2-9(23)19-17(20)28/h2-3,7-8,10-16,21,24-27H,4-5H2,1H3,(H,18,22)(H,29,30)(H,31,32)(H,19,23,28)/p-2/t7-,8-,10-,11-,12-,13-,14-,15-,16-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00050 EHMN_ABBREVIATION: C00043
is: SBO:0000247
constant: false
type: Species
is: CHEBI:57705
boundary condition: false
has only substance units: false
initial amount: NaN
initial concentration: 1.0

metaM cs e deg7 l
type: Species
initial amount: NaN
name: chondroitin sulfate E (GalNAc4,6diS-GlcA), degradation product 7
boundary condition: false
is: CHEBI:15936
is: SBO:0000247
has only substance units: false
notes: FORMULA: C23H35O27S2 CHARGE: -3
constant: false
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110042#_5de0cc82_c045_403d_9448_eace8d4f817c
is: A0PJK1
name: SLC5A10
is: SBO:0000252
has only substance units: false
boundary condition: true
initial amount: NaN
type: Species
initial concentration: NaN
is encoded by: hsa:125206
constant: false

metaR CRNCAR3tp
is described by: ECO:0000000
product: MODEL1310110042#
is: SBO:0000185
reversible: false
type: Reaction
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 0 AUTHORS: NOTES:copied from NCD's CRNCARtp NJ
reactant: MODEL1310110042#
name: carnitine-propcarnitine carrier, peroxisomal
kinetic law: MODEL1310110042#

metaM sphs1p e
initial amount: NaN
name: sphingosine 1-phosphate(1-)
is: CHEBI:60119
constant: false
notes: FORMULA: C18H37NO5P CHARGE: -1 INCHI: InChI=1S/C18H38NO5P/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-18(20)17(19)16-24-25(21,22)23/h14-15,17-18,20H,2-13,16,19H2,1H3,(H2,21,22,23)/p-1/b15-14+/t17-,18+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01702 EHMN_ABBREVIATION: C06124
is: SBO:0000247
type: Species
initial concentration: 1.0
is: HMDB00277
boundary condition: false
has only substance units: false

metaM 6dhf e
boundary condition: false
initial concentration: 1.0
is: SBO:0000247
type: Species
name: hexaglutamyl folate (DHF)
is: HMDB06563
has only substance units: false
initial amount: NaN
constant: false
notes: FORMULA: C44H49N12O21 CHARGE: -7 INCHI: InChI=1/C44H54N12O21/c45-21(36(66)67)5-10-26(57)43(15-30(61)62,27(58)11-6-22(46)37(68)69)44(28(59)12-7-23(47)38(70)71,41(76)77-31(63)14-9-25(49)40(74)75)56(29(60)13-8-24(48)39(72)73)35(65)18-1-3-19(4-2-18)51-16-20-17-52-33-32(53-20)34(64)55-42(50)54-33/h1-4,17,21-25,51H,5-16,45-49H2,(H,61,62)(H,66,67)(H,68,69)(H,70,71)(H,72,73)(H,74,75)(H3,50,52,54,55,64)/t21-,22-,23-,24-,25-,44+/m0/s1

metaR r0723
modifier: MODEL1310110042#
type: Reaction
product: MODEL1310110042#
is described by: ECO:0000000
reversible: false
notes: GENE_ASSOCIATION: (AA177072.1) or (2194.1) or (54995.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.1.1.35 Confidence Level: 0 AUTHORS: PMID:10231530,PMID:10329704,PMID:1550553,PMID:1651711,PMID:7150615,PMID:8188243,PMID:8687463,PMID:9553139 NOTES:
reactant: MODEL1310110042#
is version of: http://identifiers.org/ec-code/2.3.1.41
name: (S)-3-Hydroxydodecanoyl-CoA:NAD+ oxidoreductase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:1.1.1.211 EC:1.1.1.35
fast: false
kinetic law: MODEL1310110042#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.3.1.85

metaR r0610
reactant: MODEL1310110042#
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 2.7.1.11 Confidence Level: 0 AUTHORS: PMID:131802,PMID:1810251,PMID:193556,PMID:2987258,PMID:6091737 NOTES:
is: SBO:0000176
reversible: true
fast: false
type: Reaction
name: CTP:D-Tagatose 6-phosphate 1-phosphotransferase Galactose metabolism EC:2.7.1.11
is described by: ECO:0000000
kinetic law: MODEL1310110042#
product: MODEL1310110042#

metaR 4MOPte
is described by: ECO:0000134
product: MODEL1310110042#
name: Transport of 4-methyl-2-oxopentanoate
reversible: true
kinetic law: MODEL1310110042#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
is: SBO:0000185
reactant: MODEL1310110042#
fast: false

metaM htaxol e
initial amount: NaN
name: 6 alpha hydroxy taxol/ 6 alpha hydroxy paclitaxel
is: CHEBI:32366
has only substance units: false
boundary condition: false
constant: false
is: SBO:0000247
is: HMDB02259
type: Species
notes: FORMULA: C47H31NO15 CHARGE: 0 INCHI: InChI=1/C47H51NO15/c1-24-30(61-43(57)33(51)32(27-16-10-7-11-17-27)48-41(55)28-18-12-8-13-19-28)22-47(58)40(62-42(56)29-20-14-9-15-21-29)36-45(6,38(54)35(60-25(2)49)31(24)44(47,4)5)37(53)34(52)39-46(36,23-59-39)63-26(3)50/h7-21,30,32-37,39-40,51-53,58H,22-23H2,1-6H3,(H,48,55)/t30-,32-,33+,34-,35+,36-,37-,39+,40-,45+,46-,47-/m1/s1
initial concentration: 1.0

metaM dolp U c
name: dolichyl phosphate(2-)
boundary condition: false
is: SBO:0000247
notes: FORMULA: C1025H1670O40P10 CHARGE: -20 INCHI: InChI=1S/C25H45O4P/c1-21(2)11-7-12-22(3)13-8-14-23(4)15-9-16-24(5)17-10-18-25(6)19-20-29-30(26,27)28/h11,13,15,17,25H,7-10,12,14,16,18-20H2,1-6H3,(H2,26,27,28)/p-2/b22-13+,23-15+,24-17- EHMN_ABBREVIATION: C00110
initial amount: NaN
has only substance units: false
is: CHEBI:57683
type: Species
initial concentration: 1.0
constant: false

http://identifiers.org/biomodels.db/MODEL1310110042#_7b159c29_45df_449c_a16e_13d978e82904
has only substance units: false
boundary condition: true
is: SBO:0000252
is: Q16762
is encoded by: hsa:7263
constant: false
name: TST
initial amount: NaN
type: Species
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110042#_5094ac33_06eb_435a_a989_546be19add1f
has part: B3KT19
initial concentration: NaN
name: PIK3CB:PIK3R1
type: Species
is encoded by: hsa:5291
has part: B4DER4
constant: false
has only substance units: false
is: SBO:0000297
initial amount: NaN
is encoded by: hsa:5295
boundary condition: true

metaR CH25H
reactant: MODEL1310110042#
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/1.14.99.38
kinetic law: MODEL1310110042#
reversible: false
product: MODEL1310110042#
is: SBO:0000176
modifier: MODEL1310110042#
name: cholesterol 25-hydroxylase
type: Reaction
notes: GENE_ASSOCIATION: (9023.1) SUBSYSTEM: Bile acid synthesis EC Number: Confidence Level: 4 AUTHORS: NOTES:NJ
fast: false

metaM ura e
initial amount: NaN
type: Species
has only substance units: false
initial concentration: 1.0
is: HMDB00300
notes: FORMULA: C4H4N2O2 CHARGE: 0 INCHI: InChI=1S/C4H4N2O2/c7-3-1-2-5-4(8)6-3/h1-2H,(H2,5,6,7,8) HEPATONET_1.0_ABBREVIATION: HC00106 EHMN_ABBREVIATION: C00106
name: uracil
is: SBO:0000247
boundary condition: false
is: CHEBI:17568
constant: false

http://identifiers.org/biomodels.db/MODEL1310110042#_8f5ab192_3a8b_4a90_ba91_bca6395c8bc4
name: COQ6
boundary condition: true
type: Species
initial amount: NaN
initial concentration: NaN
constant: false
has only substance units: false
is encoded by: hsa:51004
is: Q9Y2Z9
is: SBO:0000252

metaR r2359
reactant: MODEL1310110042#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
reversible: true
name: Organic anion transporter 5 Utilized transport
product: MODEL1310110042#
is: SBO:0000185
type: Reaction
fast: false
kinetic law: MODEL1310110042#
is described by: ECO:0000000

metaM dmnoncrn c
name: 4,8-dimethylnonanoyl carnitine
has only substance units: false
type: Species
is: HMDB06202
boundary condition: false
constant: false
notes: FORMULA: C18H37NO4 CHARGE: 0
is: SBO:0000247
initial concentration: 1.0
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110042#_ddd904c6_3074_4247_a388_7b9a2c684473
has only substance units: false
is: P42765
is encoded by: hsa:10449
name: ACAA2
is: SBO:0000252
constant: false
boundary condition: true
type: Species
initial concentration: NaN
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110042#_324bfcad_8572_49e9_936a_9c3fdc68b4b3
type: Species
constant: false
has only substance units: false
is: G5E9C5
is: SBO:0000252
name: PDE5A
initial concentration: NaN
boundary condition: true
initial amount: NaN
is encoded by: hsa:8654

metaR r0611
is: SBO:0000176
product: MODEL1310110042#
kinetic law: MODEL1310110042#
reversible: true
reactant: MODEL1310110042#
type: Reaction
is version of: http://identifiers.org/ec-code/1.2.3.1
is described by: ECO:0000000
modifier: MODEL1310110042#
name: ITP:D-Tagatose 6-phosphate 1-phosphotransferase Galactose metabolism EC:2.7.1.11
notes: GENE_ASSOCIATION: (316.1) SUBSYSTEM: Unassigned EC Number: 2.7.1.11 Confidence Level: 0 AUTHORS: PMID:131802,PMID:1810251 NOTES:
fast: false

metaR r2133
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
is: SBO:0000185
reversible: true
kinetic law: MODEL1310110042#
fast: false
modifier: MODEL1310110042#
is described by: ECO:0000000
product: MODEL1310110042#
reactant: MODEL1310110042#
type: Reaction
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:

metaM imp e
has only substance units: false
is: SBO:0000247
constant: false
notes: FORMULA: C10H11N4O8P CHARGE: -2 INCHI: InChI=1S/C10H13N4O8P/c15-6-4(1-21-23(18,19)20)22-10(7(6)16)14-3-13-5-8(14)11-2-12-9(5)17/h2-4,6-7,10,15-16H,1H2,(H,11,12,17)(H2,18,19,20)/p-2/t4-,6-,7-,10-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00128 EHMN_ABBREVIATION: C00130
is: CHEBI:58053
is: HMDB00175
type: Species
initial amount: NaN
initial concentration: 1.0
name: IMP(2-)
boundary condition: false

metaR EX hdcea LPAREN e RPAREN
kinetic law: MODEL1310110042#
reactant: MODEL1310110042#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for Hexadecenoate (n-C16:1)
type: Reaction

metaR r0724
kinetic law: MODEL1310110042#
product: MODEL1310110042#
name: Decanoyl-CoA:acetyl-CoA C-acyltransferase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:2.3.1.16
reversible: true
type: Reaction
notes: GENE_ASSOCIATION: (AI924226.1) or (53354.1) or (80025.1) or (79646.1) or (55229.1) or (100128062.1) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.16 Confidence Level: 0 AUTHORS: PMID:1121274,PMID:1679347,PMID:3194209,PMID:6378901,PMID:8241273 NOTES:
is described by: ECO:0000000
modifier: MODEL1310110042#
reactant: MODEL1310110042#
is version of: http://identifiers.org/ec-code/2.7.1.33
fast: false
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110042#_5a5b46fa_97d6_4524_b922_b5022f643aa0
is: B2RDZ2
boundary condition: true
type: Species
name: RFK
constant: false
has only substance units: false
initial amount: NaN
is: SBO:0000252
is encoded by: hsa:55312
initial concentration: NaN

metaR CSNATm
reversible: true
reactant: MODEL1310110042#
name: carnitine O-aceyltransferase, mitochondrial
is: SBO:0000176
kinetic law: MODEL1310110042#
is version of: http://identifiers.org/ec-code/2.3.1.7
fast: false
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (1384.1) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.7 Confidence Level: 4 AUTHORS: PMID:3759988 NOTES:TDV
modifier: MODEL1310110042#
type: Reaction
product: MODEL1310110042#

metaM HC01609 e
is: CHEBI:28766
initial amount: NaN
name: UroporphyrinogenI
type: Species
notes: FORMULA: C40H36N4O16 CHARGE: -8 INCHI: InChI=1S/C40H44N4O16/c45-33(46)5-1-17-21(9-37(53)54)29-14-26-19(3-7-35(49)50)23(11-39(57)58)31(43-26)16-28-20(4-8-36(51)52)24(12-40(59)60)32(44-28)15-27-18(2-6-34(47)48)22(10-38(55)56)30(42-27)13-25(17)41-29/h41-44H,1-16H2,(H,45,46)(H,47,48)(H,49,50)(H,51,52)(H,53,54)(H,55,56)(H,57,58)(H,59,60) EHMN_ABBREVIATION: C05766
initial concentration: 1.0
has only substance units: false
constant: false
is: SBO:0000247
boundary condition: false

metaR r2358
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
reversible: true
kinetic law: MODEL1310110042#
type: Reaction
product: MODEL1310110042#
fast: false
is described by: ECO:0000000
name: Organic anion transporter 5 Utilized transport
is: SBO:0000185
reactant: MODEL1310110042#

metaM udpacgal g
name: UDP-N-acetyl-D-galactosamine(2-)
is: HMDB00304
is: CHEBI:57847
initial amount: NaN
constant: false
type: Species
boundary condition: false
notes: FORMULA: C17H25N3O17P2 CHARGE: -2 INCHI: InChI=1S/C17H27N3O17P2/c1-6(22)18-10-13(26)11(24)7(4-21)35-16(10)36-39(31,32)37-38(29,30)33-5-8-12(25)14(27)15(34-8)20-3-2-9(23)19-17(20)28/h2-3,7-8,10-16,21,24-27H,4-5H2,1H3,(H,18,22)(H,29,30)(H,31,32)(H,19,23,28)/p-2/t7-,8-,10-,11+,12-,13-,14-,15-,16?/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00190 EHMN_ABBREVIATION: C00203
has only substance units: false
initial concentration: 1.0
is: SBO:0000247

metaR RE1518M
name: RE1518
is version of: http://identifiers.org/ec-code/1.3.99.13
type: Reaction
is: SBO:0000176
modifier: MODEL1310110042#
is version of: http://identifiers.org/ec-code/1.3.3.6
is described by: ECO:0000000
fast: false
notes: GENE_ASSOCIATION: (33.1) or (51.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.99.13 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:11356167,PMID:8973539 NOTES:
reactant: MODEL1310110042#
reversible: true
kinetic law: MODEL1310110042#
product: MODEL1310110042#

metaR AG13T1g
is: SBO:0000176
notes: GENE_ASSOCIATION: (11041.1) or (10678.1) or (93010.1) or (374907.2) or (374907.1) or (146712.1) or (10331.1) or (10678.2) or (79369.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.149 Confidence Level: 4 AUTHORS: PMID:10747980,PMID:11042166,PMID:12061784,PMID:12512857,PMID:15560372,PMID:15620693,PMID:9405606 NOTES:NCD
product: MODEL1310110042#
is described by: ECO:0000000
type: Reaction
name: N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase, Golgi apparatus
reactant: MODEL1310110042#
fast: false
reversible: false
kinetic law: MODEL1310110042#
is version of: http://identifiers.org/ec-code/2.4.1.149
modifier: MODEL1310110042#

metaR FAOXC16080x
product: MODEL1310110042#
type: Reaction
is: SBO:0000176
kinetic law: MODEL1310110042#
modifier: MODEL1310110042#
is version of: http://identifiers.org/ec-code/2.3.1.16
name: Beta oxidation of long chain fatty acid
reactant: MODEL1310110042#
is version of: http://identifiers.org/ec-code/1.3.3.6
notes: GENE_ASSOCIATION: (51.1 and 3295.1 and 30.1) or (51.1 and 30.1 and 1962.1) or (30.1 and 51.2 and 1962.1) or (3295.1 and 30.1 and 51.2) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.74 Confidence Level: 4 AUTHORS: NOTES:_4 rounds of beta ox - in peroxisome, no fad, 1ste set of beta-ox is by acyl-coa oxidase (passes electrons directly to o2 -> h2o2) c16:0 -> c8:0, 4 step FAO lumped for 2 rounds also includes EC 1.1.1.35, 1.1.1.211, 1.3.3.6, 4.2.1.17, 4.2.1.74 NJ
is version of: http://identifiers.org/ec-code/4.2.1.107
fast: false
is version of: http://identifiers.org/ec-code/1.1.1.35
is described by: ECO:0000269
reversible: false

metaR r2132
reversible: true
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
reactant: MODEL1310110042#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
modifier: MODEL1310110042#
kinetic law: MODEL1310110042#
is: SBO:0000185
is described by: ECO:0000000
type: Reaction
product: MODEL1310110042#
fast: false

metaR DOLGPP Uer
reactant: MODEL1310110042#
is: SBO:0000176
reversible: false
notes: GENE_ASSOCIATION: SUBSYSTEM: N-glycan synthesis EC Number: 3.1.4.48 Confidence Level: 0 AUTHORS: PMID:12137737 NOTES:
kinetic law: MODEL1310110042#
product: MODEL1310110042#
name: Dolichyl-beta-D-glucosyl-phosphate dolichylphosphohydrolase (uterus)
is described by: ECO:0000000
type: Reaction
fast: false

metaM HC00342 c
name: cis-aconitate(3-)
is: SBO:0000247
has only substance units: false
constant: false
notes: FORMULA: C6H3O6 CHARGE: -3 INCHI: InChI=1S/C6H6O6/c7-4(8)1-3(6(11)12)2-5(9)10/h1H,2H2,(H,7,8)(H,9,10)(H,11,12)/p-3/b3-1- EHMN_ABBREVIATION: C00417
initial concentration: 1.0
initial amount: NaN
boundary condition: false
type: Species
is: CHEBI:16383

metaR TETHEX3COAtx
name: fatty acid intracellular transport
kinetic law: MODEL1310110042#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: NOTES:interaction between peroxisomes and ER (some enzymes on the outer membrane) NJ
product: MODEL1310110042#
fast: false
reactant: MODEL1310110042#
type: Reaction
reversible: true
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110042#_752b48d8_d558_403b_9edb_1bff9f860cb6
type: Species
is encoded by: hsa:23396
boundary condition: true
is: O60331
initial amount: NaN
is: SBO:0000252
initial concentration: NaN
constant: false
name: PIP5K1C
has only substance units: false

metaR EX ribflv LPAREN e RPAREN
kinetic law: MODEL1310110042#
reactant: MODEL1310110042#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for Riboflavin
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110042#_7d399c57_9361_4ab7_9484_17970867a555
is: SBO:0000297
has part: Q53G02
has only substance units: false
initial amount: NaN
has part: P04843
has part: P39656
name: DAD1:DDOST:RPN1:RPN2
is encoded by: hsa:1603
is encoded by: hsa:6184
constant: false
initial concentration: NaN
is encoded by: hsa:1650
has part: P04844
type: Species
boundary condition: true
is encoded by: hsa:6185

http://identifiers.org/biomodels.db/MODEL1310110042#_9b63218e_5445_4dc6_8390_ae35928d6c85
initial amount: NaN
initial concentration: NaN
name: ALDH2
type: Species
is encoded by: hsa:217
constant: false
boundary condition: true
has only substance units: false
is: P05091
is: SBO:0000252

metaR HEXDIACTD
kinetic law: MODEL1310110042#
product: MODEL1310110042#
reactant: MODEL1310110042#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: transport of hexadecanedioc acid by diffusion
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110042#_58bc7c86_da00_42af_b470_c2ca749efe69
is: Q9Y6K8
constant: false
is encoded by: hsa:26289
initial amount: NaN
type: Species
initial concentration: NaN
name: AK5
boundary condition: true
is: SBO:0000252
has only substance units: false

metaR r0193
type: Reaction
reversible: true
reactant: MODEL1310110042#
product: MODEL1310110042#
fast: false
is: SBO:0000176
is described by: ECO:0000000
name: L-Cysteine L-homocysteine-lyase (deaminating) Cysteine metabolism EC:4.4.1.1
kinetic law: MODEL1310110042#
notes: GENE_ASSOCIATION: SUBSYSTEM: Cysteine Metabolism EC Number: 4.4.1.1 Confidence Level: 0 AUTHORS: PMID:10212249,PMID:629532 NOTES:

metaM prostgf2 c
initial concentration: 1.0
type: Species
is: CHEBI:57404
is: SBO:0000247
constant: false
boundary condition: false
is: HMDB01139
has only substance units: false
name: prostaglandin F2alpha(1-)
initial amount: NaN
notes: FORMULA: C20H33O5 CHARGE: -1 INCHI: InChI=1S/C20H34O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h4,7,12-13,15-19,21-23H,2-3,5-6,8-11,14H2,1H3,(H,24,25)/p-1/b7-4-,13-12+/t15-,16+,17+,18-,19+/m0/s1 EHMN_ABBREVIATION: C00639

http://identifiers.org/biomodels.db/MODEL1310110042#_c5ffa172_cd43_4af1_9689_e73bb6dc88e8
has only substance units: false
name: MANBA
initial concentration: NaN
is encoded by: hsa:4126
is: O00462
is: SBO:0000252
initial amount: NaN
boundary condition: true
constant: false
type: Species

metaR r1570
type: Reaction
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reactant: MODEL1310110042#
product: MODEL1310110042#
fast: false
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is: SBO:0000185
kinetic law: MODEL1310110042#
is described by: ECO:0000000

metaM dhcholestanate r
is: HMDB00359
initial concentration: 1.0
name: 3alpha,7alpha-Dihydroxy-5beta-cholestanate
initial amount: NaN
notes: FORMULA: C27H45O4 CHARGE: -1 INCHI: InChI=1S/C27H46O4/c1-16(6-5-7-17(2)25(30)31)20-8-9-21-24-22(11-13-27(20,21)4)26(3)12-10-19(28)14-18(26)15-23(24)29/h16-24,28-29H,5-15H2,1-4H3,(H,30,31)/t16-,17?,18+,19-,20-,21+,22+,23-,24+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01313 EHMN_ABBREVIATION: C04554
boundary condition: false
has only substance units: false
type: Species
constant: false
is: SBO:0000247
is: CHEBI:16577

metaR HSPGtly
product: MODEL1310110042#
kinetic law: MODEL1310110042#
name: heparan sulfate transport, extracellular to lysosome
is described by: ECO:0000000
fast: false
reactant: MODEL1310110042#
is: SBO:0000185
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 2 AUTHORS: NOTES:NCD
reversible: false

metaM dmhptcrn c
boundary condition: false
is: HMDB06320
initial concentration: 1.0
is: SBO:0000247
notes: FORMULA: C16H35NO4 CHARGE: 0 INCHI: InChI=1/C16H31NO4/c1-12(2)8-7-9-13(3)16(20)21-14(10-15(18)19)11-17(4,5)6/h12-14H,7-11H2,1-6H3
type: Species
constant: false
has only substance units: false
initial amount: NaN
name: 2,6 dimethylheptanoyl carnitine

metaM 3thexddcoacrn c
name: 3-hydroxy trans7,10-hexadecadienoyl carnitine
notes: FORMULA: C23H41NO5 CHARGE: 0
initial concentration: 1.0
initial amount: NaN
boundary condition: false
constant: false
is: SBO:0000247
has only substance units: false
is: HMDB02014
type: Species

metaM anth c
boundary condition: false
name: anthranilate
is: SBO:0000247
type: Species
is: CHEBI:16567
has only substance units: false
notes: FORMULA: C7H6NO2 CHARGE: -1 INCHI: InChI=1S/C7H7NO2/c8-6-4-2-1-3-5(6)7(9)10/h1-4H,8H2,(H,9,10)/p-1 HEPATONET_1.0_ABBREVIATION: HC00107 EHMN_ABBREVIATION: C00108
initial concentration: 1.0
is: HMDB01123
constant: false
initial amount: NaN

metaM biliverd c
name: biliverdin(2-)
has only substance units: false
is: HMDB01008
is: CHEBI:57991
type: Species
initial concentration: 1.0
initial amount: NaN
notes: FORMULA: C33H32N4O6 CHARGE: -2 INCHI: InChI=1S/C33H34N4O6/c1-7-20-19(6)32(42)37-27(20)14-25-18(5)23(10-12-31(40)41)29(35-25)15-28-22(9-11-30(38)39)17(4)24(34-28)13-26-16(3)21(8-2)33(43)36-26/h7-8,13-15,35H,1-2,9-12H2,3-6H3,(H,36,43)(H,37,42)(H,38,39)(H,40,41)/p-2/b26-13-,27-14-,28-15- EHMN_ABBREVIATION: C00500
is: SBO:0000247
constant: false
boundary condition: false

metaM pan4p m
is: SBO:0000247
notes: FORMULA: C11H21N2O7PS CHARGE: -2 INCHI: InChI=1S/C11H23N2O7PS/c1-11(2,7-20-21(17,18)19)9(15)10(16)13-4-3-8(14)12-5-6-22/h9,15,22H,3-7H2,1-2H3,(H,12,14)(H,13,16)(H2,17,18,19)/p-2 HEPATONET_1.0_ABBREVIATION: HC00681 EHMN_ABBREVIATION: C01134
initial amount: NaN
type: Species
boundary condition: false
is: CHEBI:47942
has only substance units: false
constant: false
name: pantetheine 4'-phosphate(2-)
initial concentration: 1.0
is: HMDB01416

http://identifiers.org/biomodels.db/MODEL1310110042#_db74cafb_2184_4908_a503_dffc6ff6a12a
boundary condition: true
initial amount: NaN
is encoded by: hsa:NM 013421
has only substance units: false
type: Species
initial concentration: NaN
name: _NM_013421_1_m
constant: false
is: SBO:0000252

metaM crvnc c
is: SBO:0000247
has only substance units: false
notes: FORMULA: C22H31O2 CHARGE: -1
name: cervonic acid, C22:6 n-3
is: HMDB02183
constant: false
boundary condition: false
is: CHEBI:36005
initial concentration: 1.0
type: Species
initial amount: NaN

metaR r0317
modifier: MODEL1310110042#
is version of: http://identifiers.org/ec-code/1.8.1.4
kinetic law: MODEL1310110042#
product: MODEL1310110042#
is version of: http://identifiers.org/ec-code/2.1.2.10
reversible: true
name: citrate hydro-lyase Citrate cycle (TCA cycle) / Glyoxylate and dicarboxylate metabolism EC:4.2.1.4
is described by: ECO:0000000
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.4.4.2
type: Reaction
notes: GENE_ASSOCIATION: (AI761708.1) or (275.1) or (1738.1) or (2731.1) SUBSYSTEM: Unassigned EC Number: 4.2.1.4 Confidence Level: 0 AUTHORS: PMID:15263083,PMID:16511074 NOTES:
reactant: MODEL1310110042#
fast: false

metaM glyc m
type: Species
name: Glycerol
is: C00116
initial concentration: 1.0
boundary condition: false
notes: FORMULA: C3H8O3 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00114 EHMN_ABBREVIATION: C00116
is: CHEBI:17754
has only substance units: false
constant: false
initial amount: NaN
is: SBO:0000247
is: HMDB00131

metaR URAt
product: MODEL1310110042#
reversible: true
reactant: MODEL1310110042#
name: uracil transport via facilated diffusion
type: Reaction
modifier: MODEL1310110042#
is: SBO:0000185
fast: false
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (3177.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12006583,PMID:12838422 NOTES:IT
kinetic law: MODEL1310110042#

metaR r0474
is described by: ECO:0000000
fast: false
is: SBO:0000176
name: 2-Deoxyadenosine 5-diphosphate:oxidized-thioredoxin 2-oxidoreductase Purine metabolism EC:1.17.4.1
reactant: MODEL1310110042#
product: MODEL1310110042#
type: Reaction
kinetic law: MODEL1310110042#
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Nucleotide interconversion EC Number: 1.17.4.1 Confidence Level: 0 AUTHORS: PMID:6121703,PMID:8074691 NOTES:

metaR PGISr
reactant: MODEL1310110042#
fast: false
product: MODEL1310110042#
is version of: http://identifiers.org/ec-code/5.3.99.4
name: Prostaglandin I2 synthase
reversible: true
modifier: MODEL1310110042#
is described by: ECO:0000134
notes: GENE_ASSOCIATION: (5740.1) SUBSYSTEM: Eicosanoid metabolism EC Number: 5.3.99.4 Confidence Level: 4 AUTHORS: PMID:2120373,PMID:2491846 NOTES:NJ
is: SBO:0000176
type: Reaction
kinetic law: MODEL1310110042#

metaM mercplac c
initial concentration: 1.0
is: http://identifiers.org/pubchem.compound/8118
notes: FORMULA: C3H5O3S CHARGE: -1 INCHI: InChI=1/C3H6O3S/c4-2(1-7)3(5)6/h2,4,7H,1H2,(H,5,6) EHMN_ABBREVIATION: C05823
initial amount: NaN
has only substance units: false
is: HMDB02127
boundary condition: false
constant: false
is: SBO:0000247
type: Species
is: C05823
name: 3-Mercaptolactate

metaR FRUt4
is described by: ECO:0000269
reversible: true
name: D-fructose transport via sodium cotransport
product: MODEL1310110042#
is: SBO:0000185
fast: false
kinetic law: MODEL1310110042#
notes: GENE_ASSOCIATION: (200010.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12748858,PMID:15607332 NOTES:NCD
reactant: MODEL1310110042#
type: Reaction
modifier: MODEL1310110042#

http://identifiers.org/biomodels.db/MODEL1310110042#_93111268_be67_4b98_be35_85825e1871a8
name: _AI620219_1_m
is encoded by: hsa:AI620219
type: Species
is: SBO:0000252
has only substance units: false
constant: false
boundary condition: true
initial amount: NaN
initial concentration: NaN

metaR SUBEACTD
kinetic law: MODEL1310110042#
product: MODEL1310110042#
reactant: MODEL1310110042#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: transport of suberic acid into cytosol (diffusion)
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110042#_eb8c6d53_9fc7_4417_b9df_1490e7260234
boundary condition: true
is: O00757
is: SBO:0000252
is encoded by: hsa:8789
name: FBP2
initial concentration: NaN
type: Species
initial amount: NaN
constant: false
has only substance units: false

metaR r1571
is: SBO:0000185
kinetic law: MODEL1310110042#
reversible: true
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reactant: MODEL1310110042#
product: MODEL1310110042#
is described by: ECO:0000000
fast: false
type: Reaction

metaR DTMPK
is described by: ECO:0000269
type: Reaction
product: MODEL1310110042#
notes: GENE_ASSOCIATION: (1841.1) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: NOTES:
fast: false
name: dTMP kinase
kinetic law: MODEL1310110042#
reversible: true
is version of: http://identifiers.org/ec-code/2.7.4.9
reactant: MODEL1310110042#
modifier: MODEL1310110042#
is: SBO:0000176

metaR r0051
product: MODEL1310110042#
name: AMP:pyrophosphate phosphoribosyltransferase Purine metabolism EC:2.4.2.7
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/3.1.3.5
reversible: true
kinetic law: MODEL1310110042#
notes: GENE_ASSOCIATION: (AI769281.1) or (30833.1) or (93034.1) or (22978.1) or (51251.1) or (4907.1) or (56953.1) or (57786.1) or (57665.1) SUBSYSTEM: Purine catabolism EC Number: 2.4.2.7 Confidence Level: 0 AUTHORS: PMID:6778226,PMID:692402 NOTES:
fast: false
is: SBO:0000176
reactant: MODEL1310110042#
type: Reaction
modifier: MODEL1310110042#

http://identifiers.org/biomodels.db/MODEL1310110042#_678d0074_89c6_4b99_ba8a_5cf6058edbf4
constant: false
name: SLC17A2
boundary condition: true
is: SBO:0000252
type: Species
has only substance units: false
initial concentration: NaN
is: O00624
initial amount: NaN
is encoded by: hsa:10246

metaR HEX10
is version of: http://identifiers.org/ec-code/2.7.1.2
kinetic law: MODEL1310110042#
is described by: ECO:0000212
name: hexokinase (D-glucosamine:ATP)
modifier: MODEL1310110042#
type: Reaction
fast: false
notes: GENE_ASSOCIATION: (2645.1) or (3099.1) or (3098.3) or (2645.2) or (80201.1) or (3098.2) or (2645.3) or (3098.1) or (3098.4) or (3101.1) or (3098.5) SUBSYSTEM: Aminosugar metabolism EC Number: 2.7.1.1 Confidence Level: 1 AUTHORS: NOTES:D-Glucose, D-mannose, D-fructose, sorbitol and D-glucosamine can act as acceptors; ITP and dATP can act as donors. The liver isoenzyme has sometimes been called glucokinase.
is version of: http://identifiers.org/ec-code/2.7.1.1
reactant: MODEL1310110042#
reversible: false
product: MODEL1310110042#
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110042#_461fbc89_d643_4c62_be22_4976f1e2c261
name: OGDHL
type: Species
boundary condition: true
has only substance units: false
is encoded by: hsa:55753
initial amount: NaN
constant: false
initial concentration: NaN
is: SBO:0000252
is: Q9ULD0

metaM mi1345p c
notes: FORMULA: C6H8O18P4 CHARGE: -8 INCHI: InChI=1S/C6H16O18P4/c7-1-3(21-25(9,10)11)2(8)5(23-27(15,16)17)6(24-28(18,19)20)4(1)22-26(12,13)14/h1-8H,(H2,9,10,11)(H2,12,13,14)(H2,15,16,17)(H2,18,19,20)/p-8/t1-,2-,3-,4+,5-,6-/m0/s1 EHMN_ABBREVIATION: C01272
is: CHEBI:57895
is: SBO:0000247
initial amount: NaN
is: HMDB01059
constant: false
type: Species
name: 1D-myo-inositol 1,3,4,5-tetrakisphosphate(8-)
has only substance units: false
boundary condition: false
initial concentration: 1.0

metaM HC01401 m
initial amount: NaN
notes: FORMULA: C33H54N7O18P3S CHARGE: -4 INCHI: InChI=1S/C33H58N7O18P3S/c1-4-5-6-7-8-9-10-11-21(41)16-24(43)62-15-14-35-23(42)12-13-36-31(46)28(45)33(2,3)18-55-61(52,53)58-60(50,51)54-17-22-27(57-59(47,48)49)26(44)32(56-22)40-20-39-25-29(34)37-19-38-30(25)40/h19-22,26-28,32,41,44-45H,4-18H2,1-3H3,(H,35,42)(H,36,46)(H,50,51)(H,52,53)(H2,34,37,38)(H2,47,48,49)/t21-,22+,26+,27+,28-,32+/m0/s1 EHMN_ABBREVIATION: C05262
constant: false
type: Species
boundary condition: false
name: (S)-3-Hydroxydodecanoyl-CoA
initial concentration: 1.0
has only substance units: false
is: SBO:0000247
is: CHEBI:27668

http://identifiers.org/biomodels.db/MODEL1310110042#_83e1e0c8_bafe_4fa0_bcbc_d07a26253c96
name: _AI348006_1_c
has only substance units: false
type: Species
initial amount: NaN
is encoded by: hsa:AI348006
constant: false
initial concentration: NaN
is: SBO:0000252
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110042#_dcc42e50_c62a_400d_a03c_6cf73dac5bc7
boundary condition: true
initial concentration: NaN
name: SLC7A8:SLC3A2
constant: false
type: Species
initial amount: NaN
has only substance units: false
is: SBO:0000297
has part: Q9UHI5
is encoded by: hsa:23428

http://identifiers.org/biomodels.db/MODEL1310110042#_10900c88_d675_4d65_b3d0_cc7a4f172d76
boundary condition: true
is: P30043
has only substance units: false
initial concentration: NaN
is: SBO:0000252
constant: false
type: Species
name: BLVRB
is encoded by: hsa:645
initial amount: NaN

metaR r2139
modifier: MODEL1310110042#
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.14
reactant: MODEL1310110042#
reversible: true
kinetic law: MODEL1310110042#
is described by: ECO:0000000
type: Reaction
fast: false
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
product: MODEL1310110042#
is: SBO:0000185

metaM mlthf c
is: CHEBI:15636
name: 5,10-Methylenetetrahydrofolate
has only substance units: false
is: C00143
initial amount: NaN
type: Species
boundary condition: false
is: SBO:0000247
initial concentration: 1.0
notes: FORMULA: C20H21N7O6 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00140 EHMN_ABBREVIATION: C00143
constant: false
is: HMDB01533

metaM c8crn e
initial amount: NaN
initial concentration: 1.0
has only substance units: false
name: octanoyl carnitine
type: Species
constant: false
notes: FORMULA: C15H29NO4 CHARGE: 0
boundary condition: false
is: SBO:0000247
is: HMDB00791
is: C02838

metaR r2028
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
product: MODEL1310110042#
fast: false
reversible: false
kinetic law: MODEL1310110042#
type: Reaction
is described by: ECO:0000000
is: SBO:0000185
modifier: MODEL1310110042#
reactant: MODEL1310110042#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.15

metaM HC02179 c
is: SBO:0000247
has only substance units: false
notes: FORMULA: C20H31O3 CHARGE: -1 INCHI: InChI=1S/C20H32O3/c21-19-17-15-13-11-9-7-5-3-1-2-4-6-8-10-12-14-16-18-20(22)23/h1,3-4,6-7,9-10,12,21H,2,5,8,11,13-19H2,(H,22,23)/b3-1-,6-4-,9-7-,12-10- EHMN_ABBREVIATION: C14748
boundary condition: false
constant: false
type: Species
is: CHEBI:34306
initial amount: NaN
initial concentration: 1.0
name: 20-hydroxy-arachidonate

metaR 3MOX4HOXPGALDOX
reactant: MODEL1310110042#
reversible: false
fast: false
is described by: ECO:0000304
name: 3-Methoxy-4-hydroxyphenylglycolaldehyde:NAD+ oxidoreductase
notes: GENE_ASSOCIATION: (222.1) or (220.1) or (221.1) or (218.1) SUBSYSTEM: Tyrosine metabolism EC Number: 1.2.1.5 Confidence Level: 2 AUTHORS: NOTES:SAB
is version of: http://identifiers.org/ec-code/1.2.1.5
is: SBO:0000176
kinetic law: MODEL1310110042#
type: Reaction
product: MODEL1310110042#
modifier: MODEL1310110042#

metaM dmhptcrn e
constant: false
name: 2,6 dimethylheptanoyl carnitine
initial concentration: 1.0
has only substance units: false
initial amount: NaN
is: SBO:0000247
notes: FORMULA: C16H35NO4 CHARGE: 0 INCHI: InChI=1/C16H31NO4/c1-12(2)8-7-9-13(3)16(20)21-14(10-15(18)19)11-17(4,5)6/h12-14H,7-11H2,1-6H3
is: HMDB06320
boundary condition: false
type: Species

metaR GLCNACASE1ly
name: alpha-N-acetylglucosaminidase, lysosomal
kinetic law: MODEL1310110042#
modifier: MODEL1310110042#
product: MODEL1310110042#
fast: false
type: Reaction
reversible: false
notes: GENE_ASSOCIATION: (4669.1) SUBSYSTEM: Heparan sulfate degradation EC Number: 3.2.1.50 Confidence Level: 4 AUTHORS: PMID:1783617,PMID:8776591,PMID:8993162 NOTES:NCD
reactant: MODEL1310110042#
is described by: ECO:0000000
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.2.1.50

metaR RTOTAL2t
reactant: MODEL1310110042#
is: SBO:0000185
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:14598172 NOTES:
reversible: true
kinetic law: MODEL1310110042#
product: MODEL1310110042#
name: RTOTAL2 transport
type: Reaction
is described by: ECO:0000000

metaR r0472
name: 2-Deoxyadenosine 5-diphosphate:oxidized-thioredoxin 2-oxidoreductase Purine metabolism EC:1.17.4.1
is described by: ECO:0000000
reversible: true
reactant: MODEL1310110042#
product: MODEL1310110042#
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Nucleotide interconversion EC Number: 1.17.4.1 Confidence Level: 0 AUTHORS: PMID:6121703,PMID:8074691 NOTES:
fast: false
kinetic law: MODEL1310110042#
type: Reaction

metaR 5MTAte
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
name: Transport of 5-S-methyl-5-thioadenosine
product: MODEL1310110042#
is: SBO:0000185
kinetic law: MODEL1310110042#
reactant: MODEL1310110042#
reversible: true
is described by: ECO:0000134
type: Reaction

metaR DNDPt41m
reactant: MODEL1310110042#
notes: GENE_ASSOCIATION: (60386.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:11226231 NOTES:IT
is described by: ECO:0000269
type: Reaction
product: MODEL1310110042#
kinetic law: MODEL1310110042#
fast: false
is: SBO:0000185
reversible: false
modifier: MODEL1310110042#
name: dUTP transport via dCDP antiport

metaR 4NPHte
is described by: ECO:0000000
name: xenobiotic transport
kinetic law: MODEL1310110042#
is: SBO:0000185
reactant: MODEL1310110042#
reversible: true
product: MODEL1310110042#
fast: false
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:8385949,PMID:9219629 NOTES:unknown mechanism, related cyp P450 metabolism reactions NJ. Physiological, Rat

metaM 3thexddcoacrn e
initial amount: NaN
notes: FORMULA: C23H41NO5 CHARGE: 0
constant: false
initial concentration: 1.0
name: 3-hydroxy trans7,10-hexadecadienoyl carnitine
boundary condition: false
is: SBO:0000247
is: HMDB02014
has only substance units: false
type: Species

metaM 3dsphgn c
name: (2S)-1-hydroxy-3-oxooctadecan-2-aminium
initial concentration: 1.0
boundary condition: false
notes: FORMULA: C18H38NO2 CHARGE: 1 INCHI: InChI=1S/C18H37NO2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-18(21)17(19)16-20/h17,20H,2-16,19H2,1H3/p+1/t17-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01019 EHMN_ABBREVIATION: C02934
initial amount: NaN
constant: false
is: SBO:0000247
type: Species
has only substance units: false
is: CHEBI:58299
is: HMDB01480

metaR PHEACGLNt
reversible: true
kinetic law: MODEL1310110042#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14681857 NOTES:SAB
is described by: ECO:0000000
type: Reaction
name: PHEACGLN extracellular transport via diffusion
is: SBO:0000185
reactant: MODEL1310110042#
product: MODEL1310110042#

metaM sphs1p c
name: sphingosine 1-phosphate(1-)
is: HMDB00277
type: Species
initial concentration: 1.0
has only substance units: false
is: CHEBI:60119
initial amount: NaN
notes: FORMULA: C18H37NO5P CHARGE: -1 INCHI: InChI=1S/C18H38NO5P/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-18(20)17(19)16-24-25(21,22)23/h14-15,17-18,20H,2-13,16,19H2,1H3,(H2,21,22,23)/p-1/b15-14+/t17-,18+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01702 EHMN_ABBREVIATION: C06124
boundary condition: false
constant: false
is: SBO:0000247

metaR r1401
reactant: MODEL1310110042#
is described by: ECO:0000000
is: SBO:0000185
type: Reaction
is version of: http://identifiers.org/ec-code/2.7.10.1
is version of: http://identifiers.org/ec-code/3.2.1.35
is version of: http://identifiers.org/ec-code/2.3.1.51
kinetic law: MODEL1310110042#
product: MODEL1310110042#
notes: GENE_ASSOCIATION: (AA177072.1) or (AA203143.1) or (56894.1) or (56895.1) or (AGPAT7.1) or (AI818585.1) or (AI971023.1) or (1956.1) or (54898.1) or (60481.1) or (79071.1) or (114799.1) or (157570.1) or (8372.1) or (LOC647190.1) or (9926.1) or (129642.1) or (MBOAT5.1) or (79143.1) or (N63787.1) or (54995.1) or (80339.1) or (9197.1) or (6901.1) or (W87865.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:6361812,PMID:8132483 NOTES:
is version of: http://identifiers.org/ec-code/2.3.1.41
is version of: http://identifiers.org/ec-code/3.1.1.3
reversible: false
fast: false
name: Facilitated diffusion
modifier: MODEL1310110042#

metaM crvnc e
is: HMDB02183
constant: false
has only substance units: false
notes: FORMULA: C22H31O2 CHARGE: -1
name: cervonic acid, C22:6 n-3
boundary condition: false
is: CHEBI:36005
type: Species
initial amount: NaN
initial concentration: 1.0
is: SBO:0000247

metaR r2136
reversible: false
reactant: MODEL1310110042#
fast: false
is: SBO:0000185
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12811560 NOTES:
is described by: ECO:0000000
type: Reaction
modifier: MODEL1310110042#
product: MODEL1310110042#
kinetic law: MODEL1310110042#
name: Major Facilitator(MFS) TCDB:2.A.1.14.6

http://identifiers.org/biomodels.db/MODEL1310110042#_659737a2_b3c9_43b5_9916_06e16e969005
is: D3DX95
type: Species
boundary condition: true
is: SBO:0000252
constant: false
name: CHAT
has only substance units: false
is encoded by: hsa:1103
initial amount: NaN
initial concentration: NaN

metaR FAOXC163x
kinetic law: MODEL1310110042#
product: MODEL1310110042#
reactant: MODEL1310110042#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: isomerization(C16:3)x
type: Reaction

metaM malthp e
is: C01936
has only substance units: false
boundary condition: false
notes: FORMULA: C42H72O36 CHARGE: 0 INCHI: InChI=1/C42H72O36/c43-1-8-15(50)16(51)24(59)37(67-8)74-31-10(3-45)69-39(26(61)18(31)53)76-33-12(5-47)71-41(28(63)20(33)55)78-35-14(7-49)72-42(29(64)22(35)57)77-34-13(6-48)70-40(27(62)21(34)56)75-32-11(4-46)68-38(25(60)19(32)54)73-30-9(2-44)66-36(65)23(58)17(30)52/h8-65H,1-7H2/t8-,9-,10-,11-,12-,13-,14-,15+,16+,17-,18-,19-,20-,21-,22-,23+,24+,25+,26+,27+,28+,29+,30+,31+,32+,33+,34+,35+,36u,37+,38+,39+,40+,41+,42+/m1/s1 EHMN_ABBREVIATION: CE2837
is: http://identifiers.org/pubchem.compound/5041
type: Species
name: maltoheptaose
is: SBO:0000247
constant: false
initial concentration: 1.0
initial amount: NaN

metaR r1998
fast: false
type: Reaction
product: MODEL1310110042#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.15
reversible: false
is: SBO:0000185
is described by: ECO:0000000
modifier: MODEL1310110042#
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reactant: MODEL1310110042#
kinetic law: MODEL1310110042#

metaM prostgf2 e
is: CHEBI:57404
is: HMDB01139
has only substance units: false
initial concentration: 1.0
type: Species
constant: false
is: SBO:0000247
notes: FORMULA: C20H33O5 CHARGE: -1 INCHI: InChI=1S/C20H34O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h4,7,12-13,15-19,21-23H,2-3,5-6,8-11,14H2,1H3,(H,24,25)/p-1/b7-4-,13-12+/t15-,16+,17+,18-,19+/m0/s1 EHMN_ABBREVIATION: C00639
initial amount: NaN
name: prostaglandin F2alpha(1-)
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110042#_cde0dcf6_145a_47d1_baa8_e781c7d13d63
name: SLCO1A2
initial amount: NaN
constant: false
type: Species
boundary condition: true
is: P46721
is encoded by: hsa:6579
initial concentration: NaN
is: SBO:0000252
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110042#_0d4f55ae_bbbe_4c67_9f6a_13fb818ccf00
initial amount: NaN
is: SBO:0000252
initial concentration: NaN
boundary condition: true
is: Q9BYV1
constant: false
name: AGXT2
type: Species
has only substance units: false
is encoded by: hsa:64902

metaM gpi hs r
initial concentration: 1.0
name: {[PE-Man-],[PE-]Man},{PE-}Man-GlcN-acylPI
initial amount: NaN
is: CHEBI:16240
is: SBO:0000247
boundary condition: false
is: HMDB03125
has only substance units: false
constant: false
type: Species
notes: FORMULA: C55H106N4O38P4FULLRCO2FULLR2CO2 CHARGE: 0

metaM o2 n
is: HMDB01377
initial amount: NaN
name: dioxygen
type: Species
initial concentration: 1.0
is: CHEBI:15379
has only substance units: false
is: SBO:0000247
boundary condition: false
constant: false
notes: FORMULA: O2 CHARGE: 0 INCHI: InChI=1S/O2/c1-2 HEPATONET_1.0_ABBREVIATION: HC00017 EHMN_ABBREVIATION: C00007

metaM c8crn c
initial concentration: 1.0
boundary condition: false
notes: FORMULA: C15H29NO4 CHARGE: 0
constant: false
type: Species
is: HMDB00791
is: C02838
initial amount: NaN
is: SBO:0000247
has only substance units: false
name: octanoyl carnitine

metaR r2137
reactant: MODEL1310110042#
modifier: MODEL1310110042#
fast: false
is: SBO:0000185
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12811560 NOTES:
is described by: ECO:0000000
type: Reaction
product: MODEL1310110042#
kinetic law: MODEL1310110042#
reversible: true
name: Major Facilitator(MFS) TCDB:2.A.1.14.6

http://identifiers.org/biomodels.db/MODEL1310110042#_162a712f_08f1_4322_b2a8_3ca6d1d0d7bc
boundary condition: true
type: Species
is: SBO:0000252
is: Q8TCD5
has only substance units: false
constant: false
is encoded by: hsa:30833
name: NT5C
initial amount: NaN
initial concentration: NaN

metaR BPNT
kinetic law: MODEL1310110042#
product: MODEL1310110042#
modifier: MODEL1310110042#
type: Reaction
notes: GENE_ASSOCIATION: (10380.1) SUBSYSTEM: Nucleotide interconversion EC Number: 3.1.3.7 Confidence Level: 4 AUTHORS: PMID:10224133 NOTES:
name: 3',5'-bisphosphate nucleotidase
reversible: false
is version of: http://identifiers.org/ec-code/3.1.3.7
is: SBO:0000176
fast: false
reactant: MODEL1310110042#
is described by: ECO:0000269

metaM HC01397 m
initial amount: NaN
initial concentration: 1.0
is: SBO:0000247
type: Species
constant: false
has only substance units: false
notes: FORMULA: C37H62N7O18P3S CHARGE: -4 INCHI: InChI=1S/C37H66N7O18P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-25(45)20-28(47)66-19-18-39-27(46)16-17-40-35(50)32(49)37(2,3)22-59-65(56,57)62-64(54,55)58-21-26-31(61-63(51,52)53)30(48)36(60-26)44-24-43-29-33(38)41-23-42-34(29)44/h23-26,30-32,36,45,48-49H,4-22H2,1-3H3,(H,39,46)(H,40,50)(H,54,55)(H,56,57)(H2,38,41,42)(H2,51,52,53)/t25-,26+,30+,31+,32-,36+/m0/s1 EHMN_ABBREVIATION: C05258
is: CHEBI:27402
boundary condition: false
name: (S)-3-Hydroxyhexadecanoyl-CoA

metaR r2352
kinetic law: MODEL1310110042#
fast: false
product: MODEL1310110042#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
name: Organic anion transporter 5 Utilized transport
reactant: MODEL1310110042#
type: Reaction
is described by: ECO:0000000
reversible: true
is: SBO:0000185

metaM HC00342 m
type: Species
is: CHEBI:16383
notes: FORMULA: C6H3O6 CHARGE: -3 INCHI: InChI=1S/C6H6O6/c7-4(8)1-3(6(11)12)2-5(9)10/h1H,2H2,(H,7,8)(H,9,10)(H,11,12)/p-3/b3-1- EHMN_ABBREVIATION: C00417
initial concentration: 1.0
initial amount: NaN
constant: false
name: cis-aconitate(3-)
is: SBO:0000247
has only substance units: false
boundary condition: false

metaR MM5cg
reversible: false
product: MODEL1310110042#
notes: GENE_ASSOCIATION: (4121.1) or (57134.1) or (10905.1) SUBSYSTEM: N-glycan synthesis EC Number: 3.2.1.113 Confidence Level: 0 AUTHORS: PMID:10915796,PMID:9592125 NOTES:NCD
fast: false
is: SBO:0000176
reactant: MODEL1310110042#
kinetic law: MODEL1310110042#
type: Reaction
is version of: http://identifiers.org/ec-code/3.2.1.113
modifier: MODEL1310110042#
is described by: ECO:0000000
name: mannosyl-oligosaccharide 1,2-alpha-mannosidase, Golgi apparatus

metaR S3TASE2ly
product: MODEL1310110042#
type: Reaction
fast: false
kinetic law: MODEL1310110042#
reversible: true
name: N-acetylglucosamine-3-sulfatase, lysosomal
is: SBO:0000176
is described by: ECO:0000000
reactant: MODEL1310110042#
notes: GENE_ASSOCIATION: SUBSYSTEM: Heparan sulfate degradation EC Number: 3.1.6.15 Confidence Level: 4 AUTHORS: PMID:7396957,PMID:8993162 NOTES:NCD

http://identifiers.org/biomodels.db/MODEL1310110042#_388f5f61_510f_4d76_baa8_b7a050551aa1
boundary condition: true
is: Q8NBL9
type: Species
has only substance units: false
is encoded by: hsa:94005
initial concentration: NaN
name: PIGS
initial amount: NaN
constant: false
is: SBO:0000252

metaM bilirub e
is: CHEBI:57977
is: SBO:0000247
boundary condition: false
name: bilirubin(2-)
constant: false
type: Species
is: HMDB00054
notes: FORMULA: C33H34N4O6 CHARGE: -2 INCHI: InChI=1S/C33H36N4O6/c1-7-20-19(6)32(42)37-27(20)14-25-18(5)23(10-12-31(40)41)29(35-25)15-28-22(9-11-30(38)39)17(4)24(34-28)13-26-16(3)21(8-2)33(43)36-26/h7-8,13-14,34-35H,1-2,9-12,15H2,3-6H3,(H,36,43)(H,37,42)(H,38,39)(H,40,41)/p-2/b26-13-,27-14- HEPATONET_1.0_ABBREVIATION: HC00385 EHMN_ABBREVIATION: C00486
initial concentration: 1.0
has only substance units: false
initial amount: NaN

metaR 34HPLFM
type: Reaction
is: SBO:0000176
name: 3-(4-hydroxyphenyl-)lactate formation
fast: false
is described by: ECO:0000000
product: MODEL1310110042#
reactant: MODEL1310110042#
reversible: false
kinetic law: MODEL1310110042#
notes: GENE_ASSOCIATION: SUBSYSTEM: Ubiquinone synthesis EC Number: Confidence Level: 2 AUTHORS: PMID:11583838,PMID:12232327 NOTES:IT reaction involved in formation of 4-hydroxybenzoate from tyrosine.

metaR r1574
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reactant: MODEL1310110042#
is: SBO:0000185
type: Reaction
kinetic law: MODEL1310110042#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
product: MODEL1310110042#
is described by: ECO:0000000
fast: false

metaR EX ksi LPAREN e RPAREN
kinetic law: MODEL1310110042#
reactant: MODEL1310110042#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: keratan sulfate I exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110042#_f47e2b35_ad19_4f23_8660_3b5e1f97e24e
initial concentration: NaN
constant: false
is encoded by: hsa:376497
type: Species
boundary condition: true
initial amount: NaN
has only substance units: false
is: SBO:0000252
name: SLC27A1

http://identifiers.org/biomodels.db/MODEL1310110042#_ab499165_531e_452a_b525_2c4435a9c06b
is: SBO:0000252
initial concentration: NaN
is encoded by: hsa:1103
type: Species
has only substance units: false
constant: false
initial amount: NaN
name: CHAT
is: Q6LEN6
boundary condition: true

metaR ILETA
is: SBO:0000176
modifier: MODEL1310110042#
fast: false
product: MODEL1310110042#
name: isoleucine transaminase
type: Reaction
is described by: ECO:0000269
kinetic law: MODEL1310110042#
reactant: MODEL1310110042#
notes: GENE_ASSOCIATION: (586.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 2.6.1.42 Confidence Level: 4 AUTHORS: PMID:6933702,PMID:9165094 NOTES:
reversible: true
is version of: http://identifiers.org/ec-code/2.6.1.42

metaR EX CE4722 LPAREN e RPAREN
kinetic law: MODEL1310110042#
reactant: MODEL1310110042#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: beta-casomorphin (1-6) exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110042#_72d5eb89_3a2f_4a23_8ceb_4b811ade85ce
name: _AL048840_1_c
constant: false
boundary condition: true
initial concentration: NaN
is encoded by: hsa:AL048840
initial amount: NaN
type: Species
has only substance units: false
is: SBO:0000252

metaR r2353
reversible: true
product: MODEL1310110042#
reactant: MODEL1310110042#
name: Organic anion transporter 5 Utilized transport
is: SBO:0000185
type: Reaction
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
is described by: ECO:0000000
kinetic law: MODEL1310110042#

metaM ptth c
initial amount: NaN
notes: FORMULA: C11H22N2O4S CHARGE: 0 INCHI: InChI=1S/C11H22N2O4S/c1-11(2,7-14)9(16)10(17)13-4-3-8(15)12-5-6-18/h9,14,16,18H,3-7H2,1-2H3,(H,12,15)(H,13,17)/t9-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00554 EHMN_ABBREVIATION: C00831
is: HMDB03426
type: Species
boundary condition: false
is: SBO:0000247
constant: false
initial concentration: 1.0
has only substance units: false
name: pantetheine
is: CHEBI:16753

metaM bilglcur r
initial concentration: 1.0
constant: false
initial amount: NaN
is: SBO:0000247
type: Species
name: mono(glucosyluronic acid)bilirubin(2-)
notes: FORMULA: C39H44N4O12 CHARGE: 0 INCHI: InChI=1S/C39H44N4O12/c1-7-20-19(6)36(50)43-27(20)14-25-18(5)23(10-12-31(46)54-39-34(49)32(47)33(48)35(55-39)38(52)53)29(41-25)15-28-22(9-11-30(44)45)17(4)24(40-28)13-26-16(3)21(8-2)37(51)42-26/h7-8,13-14,32-35,39-41,47-49H,1-2,9-12,15H2,3-6H3,(H,42,51)(H,43,50)(H,44,45)(H,52,53)/p-2/b26-13+,27-14+/t32-,33-,34+,35-,39+/m0/s1 EHMN_ABBREVIATION: C03374
has only substance units: false
boundary condition: false
is: CHEBI:57767

metaM 2dodtricoa m
initial concentration: 1.0
is: SBO:0000247
type: Species
notes: FORMULA: C33H48N7O17P3S CHARGE: -4
boundary condition: false
has only substance units: false
name: 2,6,9-dodecatrienoylcoa
is: HMDB11123
constant: false
is: C05279
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110042#_df1448d7_33b6_426a_b0c0_5f264f5559aa
is encoded by: hsa:130752
initial concentration: NaN
constant: false
is: SBO:0000252
is: Q5I0G3
initial amount: NaN
boundary condition: true
type: Species
name: MDH1B
has only substance units: false

metaR r0196
reactant: MODEL1310110042#
is version of: http://identifiers.org/ec-code/3.6.1.5
fast: false
is: SBO:0000176
is described by: ECO:0000000
kinetic law: MODEL1310110042#
notes: GENE_ASSOCIATION: (AV717590.1) or (953.1) or (956.1) or (377841.1) SUBSYSTEM: Unassigned EC Number: 2.3.1.37 Confidence Level: 0 AUTHORS: PMID:7592562 NOTES:
reversible: true
modifier: MODEL1310110042#
type: Reaction
product: MODEL1310110042#
name: Succinyl-CoA:glycine C-succinyl-transferase(decarboxylating) EC:2.3.1.37

metaM ppp9 m
has only substance units: false
constant: false
initial amount: NaN
name: Protoporphyrin
boundary condition: false
notes: FORMULA: C34H32N4O4 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00905 EHMN_ABBREVIATION: C02191
is: CHEBI:36159
is: HMDB00241
type: Species
is: SBO:0000247
initial concentration: 1.0

metaR DM n5m2masn g
kinetic law: MODEL1310110042#
reactant: MODEL1310110042#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 0 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: false
name: DM n5m2masn(g)
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110042#_2f14a4f4_8d07_42c4_a13e_4b814be2cc4c
constant: false
type: Species
is: SBO:0000252
has only substance units: false
initial amount: NaN
name: LDHB
initial concentration: NaN
is encoded by: hsa:3945
boundary condition: true
is: P07195

metaR r1575
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
product: MODEL1310110042#
fast: false
type: Reaction
is described by: ECO:0000000
reactant: MODEL1310110042#
is: SBO:0000185
reversible: true
kinetic law: MODEL1310110042#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1

metaR FATP9t
name: fatty acid electroneutral transport
is version of: http://identifiers.org/ec-code/6.2.1.3
is: SBO:0000185
notes: GENE_ASSOCIATION: (10998.1) or (11001.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10479480,PMID:12856180,PMID:15522816 NOTES:electroneutral transport NJ
reactant: MODEL1310110042#
product: MODEL1310110042#
reversible: true
fast: false
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/6.2.1.7
type: Reaction
modifier: MODEL1310110042#
kinetic law: MODEL1310110042#

metaM dec47dicoa x
initial amount: NaN
type: Species
notes: FORMULA: C31H46N7O17P3S CHARGE: -4
initial concentration: 1.0
is: http://identifiers.org/pubchem.compound/16019966
boundary condition: false
has only substance units: false
is: SBO:0000247
constant: false
name: 4,7-decadienoylcoa

metaM ser L e
is: CHEBI:17115
initial concentration: 1.0
is: HMDB00187
is: SBO:0000247
boundary condition: false
name: L-serine
notes: FORMULA: C3H7NO3 CHARGE: 0 INCHI: InChI=1S/C3H7NO3/c4-2(1-5)3(6)7/h2,5H,1,4H2,(H,6,7)/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00068
constant: false
initial amount: NaN
has only substance units: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110042#_9a8c0bf3_3c4c_4fea_be58_ac9b55e8c750
is encoded by: hsa:6898
boundary condition: true
is: P17735
constant: false
initial concentration: NaN
name: TAT
has only substance units: false
is: SBO:0000252
initial amount: NaN
type: Species

http://identifiers.org/biomodels.db/MODEL1310110042#_129a21ae_5913_4b78_8a10_247a20f31982
initial concentration: NaN
is encoded by: hsa:80025
has only substance units: false
name: PANK2
initial amount: NaN
type: Species
is: Q9BZ23
constant: false
boundary condition: true
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110042#_9cf26bda_a653_4d7e_99bb_6c2d09cc9e4c
type: Species
initial amount: NaN
name: ALDH3B2
constant: false
is: P48448
has only substance units: false
initial concentration: NaN
is: SBO:0000252
boundary condition: true
is encoded by: hsa:222

http://identifiers.org/biomodels.db/MODEL1310110042#_cbaccbb8_de52_45ef_bb47_b225ed20cf7d
is encoded by: hsa:5331
constant: false
initial amount: NaN
is: SBO:0000252
type: Species
name: PLCB3
boundary condition: true
has only substance units: false
initial concentration: NaN
is: G5E960

metaM pyr x
boundary condition: false
is: http://identifiers.org/pubchem.compound/3324
is: C00022
initial concentration: 1.0
is: SBO:0000247
name: pyruvate
constant: false
type: Species
initial amount: NaN
is: HMDB00243
has only substance units: false
notes: FORMULA: C3H3O3 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00032 EHMN_ABBREVIATION: C00022
is: CHEBI:15361

metaR EX tdchola LPAREN e RPAREN
kinetic law: MODEL1310110042#
reactant: MODEL1310110042#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: taurochenodeoxycholate exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110042#_23036f12_4dd8_49c4_8f43_450aa4bcd9b8
has only substance units: false
constant: false
is encoded by: hsa:AI824319
name: _AI824319_1_r
boundary condition: true
initial amount: NaN
initial concentration: NaN
is: SBO:0000252
type: Species

metaM acald c
boundary condition: false
initial concentration: 1.0
constant: false
is: SBO:0000247
is: HMDB00990
notes: FORMULA: C2H4O CHARGE: 0 INCHI: InChI=1S/C2H4O/c1-2-3/h2H,1H3 HEPATONET_1.0_ABBREVIATION: HC00087 EHMN_ABBREVIATION: C00084
name: acetaldehyde
initial amount: NaN
type: Species
is: CHEBI:15343
has only substance units: false

metaR NACHEX19ly
modifier: MODEL1310110042#
name: beta-N-acetylhexosaminidase, lysosomal
fast: false
product: MODEL1310110042#
kinetic law: MODEL1310110042#
notes: GENE_ASSOCIATION: (3074.1) or (3073.1 and 3074.1) or (3073.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.52 Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12706724,PMID:8993162 NOTES:NCD
is: SBO:0000176
reactant: MODEL1310110042#
reversible: false
type: Reaction
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/3.2.1.52

http://identifiers.org/biomodels.db/MODEL1310110042#_6800c48c_0841_4376_a00b_f9869160244d
is encoded by: hsa:8704
initial concentration: NaN
has only substance units: false
type: Species
boundary condition: true
name: B4GALT2
constant: false
is: SBO:0000252
initial amount: NaN

metaR r1551
kinetic law: MODEL1310110042#
product: MODEL1310110042#
is: SBO:0000185
reactant: MODEL1310110042#
is described by: ECO:0000000
type: Reaction
fast: false
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1

metaM o2 r
is: HMDB01377
is: SBO:0000247
type: Species
is: C00007
notes: FORMULA: O2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00017 EHMN_ABBREVIATION: C00007
has only substance units: false
boundary condition: false
initial amount: NaN
constant: false
initial concentration: 1.0
name: O2
is: CHEBI:15379

metaR r1573
kinetic law: MODEL1310110042#
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reactant: MODEL1310110042#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
fast: false
is described by: ECO:0000000
type: Reaction
product: MODEL1310110042#
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110042#_aa811dd1_61e8_4378_b98e_e6b046c71882
is: SBO:0000252
boundary condition: true
initial amount: NaN
is: F5GZG6
initial concentration: NaN
name: TPK1
type: Species
has only substance units: false
constant: false
is encoded by: hsa:27010

metaM cit m
initial concentration: 1.0
is: C00158
is: SBO:0000247
boundary condition: false
is: CHEBI:16947
constant: false
initial amount: NaN
name: Citrate
notes: FORMULA: C6H5O7 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00153 EHMN_ABBREVIATION: C00158
type: Species
has only substance units: false
is: HMDB00094

http://identifiers.org/biomodels.db/MODEL1310110042#_c35d337b_051d_489c_b749_76e85799f2a3
is: SBO:0000252
constant: false
has only substance units: false
boundary condition: true
type: Species
name: _642502_1_c
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:642502

metaM T antigen g
initial concentration: 1.0
is: CHEBI:22783
has only substance units: false
name: T antigen (core 1)
notes: FORMULA: C14H24NO10X CHARGE: 0
boundary condition: false
type: Species
constant: false
initial amount: NaN
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110042#_2ea743b4_eddf_48b7_a218_2f5cdb72b92b
initial amount: NaN
constant: false
is: SBO:0000252
is encoded by: hsa:218
boundary condition: true
name: ALDH3A1
type: Species
initial concentration: NaN
is: P30838
has only substance units: false

metaM HC02179 e
has only substance units: false
initial concentration: 1.0
boundary condition: false
is: CHEBI:34306
notes: FORMULA: C20H31O3 CHARGE: -1 INCHI: InChI=1S/C20H32O3/c21-19-17-15-13-11-9-7-5-3-1-2-4-6-8-10-12-14-16-18-20(22)23/h1,3-4,6-7,9-10,12,21H,2,5,8,11,13-19H2,(H,22,23)/b3-1-,6-4-,9-7-,12-10- EHMN_ABBREVIATION: C14748
is: SBO:0000247
initial amount: NaN
name: 20-hydroxy-arachidonate
type: Species
constant: false

metaM ser L c
type: Species
is: CHEBI:17115
is: HMDB00187
is: SBO:0000247
boundary condition: false
name: L-serine
notes: FORMULA: C3H7NO3 CHARGE: 0 INCHI: InChI=1S/C3H7NO3/c4-2(1-5)3(6)7/h2,5H,1,4H2,(H,6,7)/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00068
has only substance units: false
constant: false
initial amount: NaN
initial concentration: 1.0

metaM CE0713 m
is: SBO:0000247
boundary condition: false
is: HMDB02329
is: CHEBI:30623
initial concentration: 1.0
has only substance units: false
name: 3-oxolinoleoyl-CoA
constant: false
notes: FORMULA: C39H60N7O18P3S CHARGE: -4 INCHI: InChI=1/C39H64N7O18P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-27(47)22-30(49)68-21-20-41-29(48)18-19-42-37(52)34(51)39(2,3)24-61-67(58,59)64-66(56,57)60-23-28-33(63-65(53,54)55)32(50)38(62-28)46-26-45-31-35(40)43-25-44-36(31)46/h8-9,11-12,25-26,28,32-34,38,50-51H,4-7,10,13-24H2,1-3H3,(H,41,48)(H,42,52)(H,56,57)(H,58,59)(H2,40,43,44)(H2,53,54,55)/p-4/b9-8-,12-11-/t28-,32+,33+,34u,38-/m0/s1 EHMN_ABBREVIATION: CE0713
type: Species
initial amount: NaN

metaM hdd2crn m
has only substance units: false
is: HMDB06317
notes: FORMULA: C23H43NO4 CHARGE: 0 INCHI: InChI=1/C23H43NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-23(27)28-21(19-22(25)26)20-24(2,3)4/h17-18,21H,5-16,19-20H2,1-4H3/b18-17+
is: SBO:0000247
type: Species
constant: false
initial concentration: 1.0
boundary condition: false
initial amount: NaN
name: trans-Hexadec-2-enoyl carnitine

metaR C180CRNt
reversible: false
product: MODEL1310110042#
notes: GENE_ASSOCIATION: (788.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: PMID:14598172 NOTES:TV
fast: false
kinetic law: MODEL1310110042#
is: SBO:0000185
reactant: MODEL1310110042#
modifier: MODEL1310110042#
name: C180 transport into the mitochondria
is described by: ECO:0000269
type: Reaction

metaR r1552
is: SBO:0000185
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reversible: true
reactant: MODEL1310110042#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
type: Reaction
product: MODEL1310110042#
is described by: ECO:0000000
fast: false
kinetic law: MODEL1310110042#

metaR G6PDH2rer
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.1.1.47
name: glucose 6-phosphate dehydrogenase, endoplasmic reticulum
is described by: ECO:0000269
fast: false
reversible: true
kinetic law: MODEL1310110042#
notes: GENE_ASSOCIATION: (9563.1) SUBSYSTEM: Pentose phosphate pathway EC Number: 1.1.1.47 Confidence Level: 4 AUTHORS: PMID:10349511,PMID:12831846,PMID:2156506 NOTES:NCD
reactant: MODEL1310110042#
product: MODEL1310110042#
modifier: MODEL1310110042#
type: Reaction

metaM mpdol L c
type: Species
has only substance units: false
initial concentration: 1.0
boundary condition: false
initial amount: NaN
is: CHEBI:18396
notes: FORMULA: C1300H2128N20O220P20 CHARGE: -20 INCHI: InChI=1S/C47H82N2O22P2/c1-26(2)13-9-14-27(3)15-10-16-28(4)17-11-18-29(5)19-12-20-30(6)21-22-64-72(60,61)71-73(62,63)70-46-37(49-32(8)54)40(57)43(35(25-52)67-46)68-45-36(48-31(7)53)39(56)44(34(24-51)66-45)69-47-42(59)41(58)38(55)33(23-50)65-47/h13,15,17,19,30,33-47,50-52,55-59H,9-12,14,16,18,20-25H2,1-8H3,(H,48,53)(H,49,54)(H,60,61)(H,62,63)/b27-15+,28-17+,29-19+/t30?,33-,34-,35-,36-,37-,38-,39-,40-,41+,42+,43-,44-,45+,46-,47+/m1/s1
is: SBO:0000247
name: beta-D-Mannosyldiacetylchitobiosyldiphosphodolichol, human liver homolog
constant: false

metaM CE2838 e
name: maltononaose
has only substance units: false
type: Species
is: C01936
boundary condition: false
initial amount: NaN
is: http://identifiers.org/pubchem.compound/5041
constant: false
is: SBO:0000247
initial concentration: 1.0
notes: FORMULA: C54H92O46 CHARGE: 0 INCHI: InChI=1/C54H92O46/c55-1-10-19(64)20(65)30(75)47(85-10)94-39-12(3-57)87-49(32(77)22(39)67)96-41-14(5-59)89-51(34(79)24(41)69)98-43-16(7-61)91-53(36(81)26(43)71)100-45-18(9-63)92-54(37(82)28(45)73)99-44-17(8-62)90-52(35(80)27(44)72)97-42-15(6-60)88-50(33(78)25(42)70)95-40-13(4-58)86-48(31(76)23(40)68)93-38-11(2-56)84-46(83)29(74)21(38)66/h10-83H,1-9H2/t10-,11-,12-,13-,14-,15-,16-,17-,18-,19+,20+,21-,22-,23-,24-,25-,26-,27-,28-,29+,30+,31+,32+,33+,34+,35+,36+,37+,38+,39+,40+,41+,42+,43+,44+,45+,46u,47+,48+,49+,50+,51+,52+,53+,54+/m1/s1 EHMN_ABBREVIATION: CE2838

metaR r1578
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
fast: false
is: SBO:0000185
type: Reaction
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
product: MODEL1310110042#
reversible: true
reactant: MODEL1310110042#
is described by: ECO:0000000
kinetic law: MODEL1310110042#

metaR FAOXC184C163x
kinetic law: MODEL1310110042#
product: MODEL1310110042#
reactant: MODEL1310110042#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C18:4-->C16:3)x
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110042#_bf254439_0f94_4100_8419_361dce0c1df1
initial amount: NaN
has only substance units: false
is: SBO:0000252
initial concentration: NaN
type: Species
boundary condition: true
constant: false
is encoded by: hsa:NOS2A
name: _NOS2A_1_e

http://identifiers.org/biomodels.db/MODEL1310110042#_c08acc82_6b11_4d99_ad1a_16dca5836a53
initial concentration: NaN
type: Species
boundary condition: true
initial amount: NaN
is encoded by: hsa:259230
is: D3DWC4
name: SGMS1
is: SBO:0000252
constant: false
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110042#_66f340c6_ac7e_4b69_9491_5707022e9c0e
name: _AA854479_1_m
initial amount: NaN
constant: false
has only substance units: false
initial concentration: NaN
boundary condition: true
type: Species
is encoded by: hsa:AA854479
is: SBO:0000252

metaR LNLNCGt
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11788354,PMID:12864740 NOTES:NJ
reversible: true
is described by: ECO:0000000
reactant: MODEL1310110042#
product: MODEL1310110042#
fast: false
name: fatty acid transport via diffusion
type: Reaction
is: SBO:0000185
kinetic law: MODEL1310110042#

metaM pmtcoa c
boundary condition: false
initial amount: NaN
has only substance units: false
is: HMDB01338
constant: false
type: Species
notes: FORMULA: C37H62N7O17P3S CHARGE: -4
is: SBO:0000247
is: CHEBI:3454
name: Palmitoyl-CoA (n-C16:0CoA)
is: C00154
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110042#_8d653d74_1926_44bc_83a7_a770ed02b9fa
is encoded by: hsa:1636
is: B4DKH4
constant: false
has only substance units: false
initial concentration: NaN
name: ACE
boundary condition: true
type: Species
is: SBO:0000252
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110042#_b6e72765_0aa2_41fa_bc9d_8d0654c24d49
boundary condition: true
name: ABAT
is encoded by: hsa:18
initial amount: NaN
type: Species
initial concentration: NaN
is: SBO:0000252
has only substance units: false
constant: false
is: P80404

metaM 5dpmev c
boundary condition: false
is: HMDB01090
notes: FORMULA: C6H10O10P2 CHARGE: -4 INCHI: InChI=1S/C6H14O10P2/c1-6(9,4-5(7)8)2-3-15-18(13,14)16-17(10,11)12/h9H,2-4H2,1H3,(H,7,8)(H,13,14)(H2,10,11,12)/t6-/m1/s1
has only substance units: false
is: SBO:0000247
name: (R)-5-Diphosphomevalonate
initial amount: NaN
initial concentration: 1.0
type: Species
constant: false

metaR r1291
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: 6.2.1.3 Confidence Level: 0 AUTHORS: PMID:8584017 NOTES:
is: SBO:0000185
is described by: ECO:0000000
reversible: true
type: Reaction
kinetic law: MODEL1310110042#
fast: false
name: Postulated transport reaction
product: MODEL1310110042#
reactant: MODEL1310110042#

metaR CYSSNAT5tc
kinetic law: MODEL1310110042#
product: MODEL1310110042#
reactant: MODEL1310110042#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: transport of L-Cysteine into the cell coupled with co-transport with Sodium and counter transport with proton by SNAT5 transporter.
type: Reaction

metaR EX biocyt LPAREN e RPAREN
kinetic law: MODEL1310110042#
reactant: MODEL1310110042#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Biocytin exchange
type: Reaction

metaM mi1p D c
is: SBO:0000247
name: 1D-myo-inositol 1-phosphate(2-)
type: Species
constant: false
is: CHEBI:58433
is: HMDB02985
notes: FORMULA: C6H11O9P CHARGE: -2 INCHI: InChI=1S/C6H13O9P/c7-1-2(8)4(10)6(5(11)3(1)9)15-16(12,13)14/h1-11H,(H2,12,13,14)/p-2/t1-,2-,3+,4-,5-,6-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00698
has only substance units: false
initial concentration: 1.0
boundary condition: false
initial amount: NaN

metaR r2516
is described by: ECO:0000000
reactant: MODEL1310110042#
kinetic law: MODEL1310110042#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 0 AUTHORS: PMID:12739169,PMID:18305372 NOTES:
fast: false
type: Reaction
product: MODEL1310110042#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
reversible: true

metaR r1553
product: MODEL1310110042#
fast: false
kinetic law: MODEL1310110042#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is: SBO:0000185
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
type: Reaction
is described by: ECO:0000000
reactant: MODEL1310110042#
reversible: true

metaR DOLMANP Lter
kinetic law: MODEL1310110042#
fast: false
product: MODEL1310110042#
notes: GENE_ASSOCIATION: SUBSYSTEM: N-glycan synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:12137737 NOTES:
name: dolichol-phosphate mannose flippase (liver)
is described by: ECO:0000000
reversible: false
is: SBO:0000185
type: Reaction
reactant: MODEL1310110042#

metaM gua c
type: Species
notes: FORMULA: C5H5N5O CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00219 EHMN_ABBREVIATION: C00242
is: C00242
is: SBO:0000247
initial amount: NaN
has only substance units: false
boundary condition: false
is: HMDB00132
initial concentration: 1.0
name: Guanine
is: CHEBI:16235
constant: false

metaR EX tetdece1crn
kinetic law: MODEL1310110042#
reactant: MODEL1310110042#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for tetradecenoyl carnitine
type: Reaction

metaR r1844
name: Y+LAT2 Utilized transport
reversible: false
type: Reaction
kinetic law: MODEL1310110042#
is described by: ECO:0000000
reactant: MODEL1310110042#
is: SBO:0000185
modifier: MODEL1310110042#
product: MODEL1310110042#
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
fast: false

metaM dmnoncrn m
initial amount: NaN
type: Species
notes: FORMULA: C18H37NO4 CHARGE: 0 INCHI: InChI=1/C18H35NO4/c1-14(2)8-7-9-15(3)10-11-18(22)23-16(12-17(20)21)13-19(4,5)6/h14-16H,7-13H2,1-6H3
is: HMDB06202
is: SBO:0000247
name: 4,8 dimethylnonanoyl carnitine
boundary condition: false
constant: false
initial concentration: 1.0
has only substance units: false

metaR r1579
kinetic law: MODEL1310110042#
type: Reaction
reversible: true
is described by: ECO:0000000
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is: SBO:0000185
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
product: MODEL1310110042#
reactant: MODEL1310110042#

metaR EX abt LPAREN e RPAREN
kinetic law: MODEL1310110042#
reactant: MODEL1310110042#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: L-Arabinitol exchange
type: Reaction

metaM cholcoa c
constant: false
is: HMDB01374
boundary condition: false
type: Species
initial concentration: 1.0
name: choloyl-CoA(4-)
has only substance units: false
is: SBO:0000247
is: CHEBI:57373
notes: FORMULA: C45H70N7O20P3S CHARGE: -4 INCHI: InChI=1S/C45H74N7O20P3S/c1-23(26-7-8-27-34-28(18-31(55)45(26,27)5)44(4)12-10-25(53)16-24(44)17-29(34)54)6-9-33(57)76-15-14-47-32(56)11-13-48-41(60)38(59)43(2,3)20-69-75(66,67)72-74(64,65)68-19-30-37(71-73(61,62)63)36(58)42(70-30)52-22-51-35-39(46)49-21-50-40(35)52/h21-31,34,36-38,42,53-55,58-59H,6-20H2,1-5H3,(H,47,56)(H,48,60)(H,64,65)(H,66,67)(H2,46,49,50)(H2,61,62,63)/p-4/t23-,24+,25-,26-,27+,28+,29-,30-,31+,34+,36-,37-,38+,42-,44+,45-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00844 EHMN_ABBREVIATION: C01794
initial amount: NaN

metaR EX prostgh2 LPAREN e RPAREN
kinetic law: MODEL1310110042#
reactant: MODEL1310110042#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: prostaglandin H2(1-) exchange
type: Reaction

metaR ACCOAgt
is: SBO:0000185
reversible: true
modifier: MODEL1310110042#
kinetic law: MODEL1310110042#
reactant: MODEL1310110042#
is described by: ECO:0000269
fast: false
type: Reaction
name: acetyl-coa transport
product: MODEL1310110042#
notes: GENE_ASSOCIATION: (9197.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12739170 NOTES:transport between cytosol and Golgi/ER presumed presumed facilitated transport, but unknown co-substrates, see PMID: 12739170, Hirabayashi et al NJ

metaR GGLUCT
name: gamma-glutamylcyclotransferase
is: SBO:0000185
reactant: MODEL1310110042#
modifier: MODEL1310110042#
kinetic law: MODEL1310110042#
fast: false
reversible: false
is version of: http://identifiers.org/ec-code/2.3.2.4
product: MODEL1310110042#
notes: GENE_ASSOCIATION: (79017.1) SUBSYSTEM: Glutathione metabolism EC Number: 2.3.2.4 Confidence Level: 4 AUTHORS: PMID:2570694 NOTES:SAB
type: Reaction
is described by: ECO:0000269

metaR r1292
product: MODEL1310110042#
is described by: ECO:0000000
reversible: true
reactant: MODEL1310110042#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: 6.2.1.3 Confidence Level: 0 AUTHORS: PMID:8584017 NOTES:
name: Postulated transport reaction
is: SBO:0000185
kinetic law: MODEL1310110042#
fast: false

metaR DOPAt4 2 r
reactant: MODEL1310110042#
notes: GENE_ASSOCIATION: (6530.1) or (6531.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12719981 NOTES:SAB
is described by: ECO:0000269
product: MODEL1310110042#
kinetic law: MODEL1310110042#
reversible: true
type: Reaction
modifier: MODEL1310110042#
fast: false
name: Dopamine reversible transport in via sodium symport (1:2)
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110042#_9db6dae8_2a52_42af_800f_2c0d98d6d919
has only substance units: false
is encoded by: hsa:248
is: SBO:0000252
type: Species
initial amount: NaN
initial concentration: NaN
name: ALPI
is: P09923
constant: false
boundary condition: true

metaR DOLGLCP Uter
name: Dolichyl beta-D-glucosyl phosphate flippase (uterus)
kinetic law: MODEL1310110042#
notes: GENE_ASSOCIATION: SUBSYSTEM: N-glycan synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:12137737 NOTES:
is: SBO:0000185
type: Reaction
fast: false
reversible: false
is described by: ECO:0000000
product: MODEL1310110042#
reactant: MODEL1310110042#

metaR r1554
kinetic law: MODEL1310110042#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reactant: MODEL1310110042#
reversible: true
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is described by: ECO:0000000
fast: false
product: MODEL1310110042#
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110042#_f341bb06_6f8a_4004_ba24_7789323832cd
has only substance units: false
type: Species
initial amount: NaN
name: GUCY1A2:GUCY1B3
boundary condition: true
has part: Q02153
has part: P33402
is encoded by: hsa:2977
is: SBO:0000297
initial concentration: NaN
is encoded by: hsa:2983
constant: false

metaR S6T13g
type: Reaction
name: galactose/N-acetylglucosamine 6-O-sulfotransferase, Golgi apparatus
modifier: MODEL1310110042#
is described by: ECO:0000000
is: SBO:0000176
notes: GENE_ASSOCIATION: (4166.1) or (10164.1) or (23563.2) or (23563.1) or (9435.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: Confidence Level: 4 AUTHORS: PMID:10330415,PMID:10491328,PMID:10913333,PMID:11278593,PMID:12403612,PMID:12855678,PMID:9722682 NOTES:NCD
product: MODEL1310110042#
reactant: MODEL1310110042#
kinetic law: MODEL1310110042#
fast: false
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110042#_0bc24919_9a34_48a3_aa1f_f9caced4ef9f
name: SLC22A1
type: Species
has only substance units: false
is encoded by: hsa:6580
initial concentration: NaN
boundary condition: true
is: O15245
initial amount: NaN
constant: false
is: SBO:0000252

metaM dmhptcrn m
has only substance units: false
name: 2,6 dimethylheptanoyl carnitine
is: HMDB06320
initial concentration: 1.0
initial amount: NaN
notes: FORMULA: C16H35NO4 CHARGE: 0 INCHI: InChI=1/C16H31NO4/c1-12(2)8-7-9-13(3)16(20)21-14(10-15(18)19)11-17(4,5)6/h12-14H,7-11H2,1-6H3
constant: false
type: Species
is: SBO:0000247
boundary condition: false

metaR r2519
is described by: ECO:0000000
name: Utilized transport
reactant: MODEL1310110042#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:16611737,PMID:18307097 NOTES:
type: Reaction
fast: false
kinetic law: MODEL1310110042#
product: MODEL1310110042#
is: SBO:0000185
reversible: true

metaR r1576
kinetic law: MODEL1310110042#
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reactant: MODEL1310110042#
product: MODEL1310110042#
is: SBO:0000185
type: Reaction
fast: false
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110042#_a20e69a1_c571_4e6d_a6c9_9c224f8c9c26
boundary condition: true
is: Q96RN1
has only substance units: false
is: SBO:0000252
type: Species
initial amount: NaN
is encoded by: hsa:116369
name: SLC26A8
constant: false
initial concentration: NaN

metaM 2dodtricoa x
type: Species
notes: FORMULA: C33H48N7O17P3S CHARGE: -4
initial concentration: 1.0
boundary condition: false
is: C05279
initial amount: NaN
name: 2,6,9-dodecatrienoylcoa
constant: false
is: SBO:0000247
is: HMDB11123
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110042#_5168c5df_5693_43d7_8dc0_fe147a2d2cfd
name: ACOX1
initial amount: NaN
type: Species
is: SBO:0000252
is: B4DK61
boundary condition: true
is encoded by: hsa:51
constant: false
has only substance units: false
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110042#_2ec602d2_f600_4862_a248_972fa5ac2fc2
is: SBO:0000252
is: Q9UPY5
has only substance units: false
name: SLC7A11
initial concentration: NaN
boundary condition: true
constant: false
is encoded by: hsa:23657
type: Species
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110042#_4fb469ee_3d52_418d_a582_14d1b079d529
initial amount: NaN
is encoded by: hsa:57134
has only substance units: false
is: Q9NR34
is: SBO:0000252
type: Species
boundary condition: true
name: MAN1C1
initial concentration: NaN
constant: false

metaM sphgn c
is: CHEBI:57817
initial amount: NaN
type: Species
is: HMDB00269
boundary condition: false
has only substance units: false
initial concentration: 1.0
notes: FORMULA: C18H40NO2 CHARGE: 1 INCHI: InChI=1S/C18H39NO2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-18(21)17(19)16-20/h17-18,20-21H,2-16,19H2,1H3/p+1/t17-,18+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00556 EHMN_ABBREVIATION: C00836
constant: false
name: sphinganine(1+)
is: SBO:0000247

metaM bilirub c
name: bilirubin(2-)
is: HMDB00054
is: SBO:0000247
has only substance units: false
notes: FORMULA: C33H34N4O6 CHARGE: -2 INCHI: InChI=1S/C33H36N4O6/c1-7-20-19(6)32(42)37-27(20)14-25-18(5)23(10-12-31(40)41)29(35-25)15-28-22(9-11-30(38)39)17(4)24(34-28)13-26-16(3)21(8-2)33(43)36-26/h7-8,13-14,34-35H,1-2,9-12,15H2,3-6H3,(H,36,43)(H,37,42)(H,38,39)(H,40,41)/p-2/b26-13-,27-14- HEPATONET_1.0_ABBREVIATION: HC00385 EHMN_ABBREVIATION: C00486
initial concentration: 1.0
constant: false
initial amount: NaN
is: CHEBI:57977
boundary condition: false
type: Species

metaR SUCCOAPET
kinetic law: MODEL1310110042#
product: MODEL1310110042#
reactant: MODEL1310110042#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: thioesterification of succinyl coa for release into cytosol
type: Reaction

metaR GAL3ST11
is described by: ECO:0000000
modifier: MODEL1310110042#
is version of: http://identifiers.org/ec-code/2.8.2.11
is: SBO:0000176
type: Reaction
reactant: MODEL1310110042#
reversible: false
kinetic law: MODEL1310110042#
fast: false
product: MODEL1310110042#
name: Galactosylceramide sulfotransferase
notes: GENE_ASSOCIATION: (9514.1) SUBSYSTEM: Sphingolipid metabolism EC Number: 2.8.2.11 Confidence Level: 4 AUTHORS: PMID:9030544 NOTES:NJ

metaM hepcoa m
is: SBO:0000247
type: Species
notes: FORMULA: C28H44N7O17P3S CHARGE: -4
initial amount: NaN
has only substance units: false
is: HMDB12969
constant: false
boundary condition: false
name: heptanoylcoa
initial concentration: 1.0

metaR ILEt5m
reversible: true
type: Reaction
fast: false
name: Isoleucine mitochondrial transport
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:11004451 NOTES:MM
is described by: ECO:0000000
product: MODEL1310110042#
reactant: MODEL1310110042#
is: SBO:0000185
kinetic law: MODEL1310110042#

metaR GLCURtly
type: Reaction
name: glucuronate transport into lysososme
product: MODEL1310110042#
kinetic law: MODEL1310110042#
reactant: MODEL1310110042#
notes: GENE_ASSOCIATION: (26503.1) SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 4 AUTHORS: PMID:10581036,PMID:2768261 NOTES:H symport into lysososome. See PMID: 2768261 and PMID: 10581036 ( for human evidence). Sialic acid storage disorders (due to transporter mutations) require import and export e.g. PMID: 2768266 NJ renamed from GLCURlt to GLCURtly - NCD
is described by: ECO:0000269
fast: false
reversible: true
is: SBO:0000185
modifier: MODEL1310110042#

http://identifiers.org/biomodels.db/MODEL1310110042#_035c1aec_6c1c_41af_8919_b423de2b868e
has only substance units: false
is encoded by: hsa:5295
constant: false
is: SBO:0000297
has part: P27986
initial concentration: NaN
initial amount: NaN
type: Species
name: PIK3CA:PIK3R1
boundary condition: true

metaM ksi pre11 g
constant: false
initial concentration: 1.0
has only substance units: false
notes: FORMULA: C129H208N9O101S3X CHARGE: -4
initial amount: NaN
is: SBO:0000247
boundary condition: false
type: Species
name: keratan sulfate I biosynthesis, precursor 11
is: CHEBI:28067

http://identifiers.org/biomodels.db/MODEL1310110042#_c22c4685_1f87_4cdc_a531_2e5f90adc47c
constant: false
is: P14618
initial concentration: NaN
is encoded by: hsa:5315
name: PKM2
has only substance units: false
is: SBO:0000252
initial amount: NaN
boundary condition: true
type: Species

metaR GALt1r
modifier: MODEL1310110042#
fast: false
kinetic law: MODEL1310110042#
notes: GENE_ASSOCIATION: (29988.1) or (6513.1) or (6515.1) or (6514.1) or (81031.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10421229,PMID:10821868,PMID:10860996,PMID:11247674,PMID:11592815,PMID:11882499,PMID:12135767,PMID:12750891,PMID:1701966,PMID:2182619,PMID:3103217,PMID:3170580,PMID:3399500,PMID:3839598,PMID:7926364,PMID:8504756,PMID:9230074,PMID:9770484 NOTES:NCD
is: SBO:0000185
reversible: true
reactant: MODEL1310110042#
is described by: ECO:0000269
type: Reaction
product: MODEL1310110042#
name: galactose transport (uniport)

metaM c51crn c
is: HMDB02366
initial amount: NaN
is: SBO:0000247
has only substance units: false
constant: false
name: tiglyl carnitine
notes: FORMULA: C12H21NO4 CHARGE: 0
boundary condition: false
initial concentration: 1.0
type: Species

metaM CE2418 m
name: (3S)-3-hydroxy-cis,cis-palmito-7,10-dienoyl-CoA
is: CHEBI:28387
initial concentration: 1.0
type: Species
notes: FORMULA: C37H58N7O18P3S CHARGE: -4 INCHI: InChI=1/C37H62N7O18P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-25(45)20-28(47)66-19-18-39-27(46)16-17-40-35(50)32(49)37(2,3)22-59-65(56,57)62-64(54,55)58-21-26-31(61-63(51,52)53)30(48)36(60-26)44-24-43-29-33(38)41-23-42-34(29)44/h8-9,11-12,23-26,30-32,36,45,48-49H,4-7,10,13-22H2,1-3H3,(H,39,46)(H,40,50)(H,54,55)(H,56,57)(H2,38,41,42)(H2,51,52,53)/p-4/b9-8-,12-11-/t25-,26-,30+,31+,32u,36-/m0/s1 EHMN_ABBREVIATION: CE2418
constant: false
is: SBO:0000247
initial amount: NaN
has only substance units: false
is: HMDB11123
boundary condition: false

metaR PHCDm
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.5.1.12
modifier: MODEL1310110042#
fast: false
name: L-1-pyrroline-3-hydroxy-5-carboxylate dehydrogenase
type: Reaction
reactant: MODEL1310110042#
notes: GENE_ASSOCIATION: (8659.1) or (8659.2) SUBSYSTEM: Arginine and Proline Metabolism EC Number: 1.5.1.12 Confidence Level: 2 AUTHORS: PMID:12660328,PMID:15849464,PMID:500817 NOTES:NCD
reversible: false
is described by: ECO:0000304
kinetic law: MODEL1310110042#
product: MODEL1310110042#

metaR L LACt2r
reversible: true
product: MODEL1310110042#
reactant: MODEL1310110042#
is: SBO:0000185
modifier: MODEL1310110042#
is described by: ECO:0000269
kinetic law: MODEL1310110042#
notes: GENE_ASSOCIATION: (9194.1) or (23539.1) or (6566.1) or (9123.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10493836,PMID:10510291,PMID:11101640,PMID:11827462,PMID:12739169,PMID:7835905,PMID:8476015,PMID:9425115,PMID:9508842,PMID:9649795,PMID:9786900,PMID:9824713 NOTES:NCD
type: Reaction
name: L-lactate reversible transport via proton symport
fast: false

metaM gua e
initial amount: NaN
notes: FORMULA: C5H5N5O CHARGE: 0 INCHI: InChI=1S/C5H5N5O/c6-5-9-3-2(4(11)10-5)7-1-8-3/h1H,(H4,6,7,8,9,10,11) HEPATONET_1.0_ABBREVIATION: HC00219 EHMN_ABBREVIATION: C00242
is: HMDB00132
is: CHEBI:16235
is: SBO:0000247
type: Species
boundary condition: false
has only substance units: false
initial concentration: 1.0
name: guanine
constant: false

metaM sT antigen g
is: CHEBI:16565
initial amount: NaN
is: SBO:0000247
notes: FORMULA: C25H40N2O18X CHARGE: -1
boundary condition: false
initial concentration: 1.0
name: sialyl-T antigen
type: Species
has only substance units: false
constant: false

metaR ATPS4m
reactant: MODEL1310110042#
is version of: http://identifiers.org/ec-code/3.6.4.6
is described by: ECO:0000134
product: MODEL1310110042#
is: SBO:0000185
fast: false
notes: GENE_ASSOCIATION: (513.1 and 498.2 and 506.1 and 509.2 and 514.1 or 498.2 and 513.2 and 514.2 and 506.1 and 509.2 or 513.1 and 509.1 and 498.1 and 514.2 and 506.1 or 498.2 and 513.2 and 506.1 and 509.2 and 514.1 or 513.2 and 498.1 and 514.2 and 506.1 and 509.2 or 513.1 and 498.1 and 506.1 and 509.2 and 514.1 or 513.1 and 498.2 and 514.2 and 506.1 and 509.2 or 513.1 and 498.2 and 509.1 and 506.1 and 514.1 or 498.2 and 509.1 and 513.2 and 506.1 and 514.1 or 513.2 and 498.1 and 506.1 and 509.2 and 514.1 or 513.2 and 514.2 and 506.1 and 509.2 and 498.3 or 513.2 and 506.1 and 509.2 and 498.3 and 514.1 or 513.1 and 509.1 and 506.1 and 498.3 and 514.1 or 509.1 and 513.2 and 514.2 and 506.1 and 498.3 or 513.1 and 498.2 and 509.1 and 514.2 and 506.1 or 513.1 and 498.1 and 514.2 and 506.1 and 509.2 or 513.1 and 509.1 and 498.1 and 506.1 and 514.1 or 513.1 and 506.1 and 509.2 and 498.3 and 514.1 or 509.1 and 513.2 and 506.1 and 498.3 and 514.1 or 513.1 and 514.2 and 506.1 and 509.2 and 498.3 or 509.1 and 513.2 and 498.1 and 506.1 and 514.1 or 513.1 and 509.1 and 514.2 and 506.1 and 498.3 or 498.2 and 509.1 and 513.2 and 514.2 and 506.1 or 509.1 and 513.2 and 498.1 and 514.2 and 506.1) and (10632.1 and 4905.1 and 10476.1 and 9551.3 and 522.5 and 516.2 and 521.1 and 515.1 or 518.3 and 4905.1 and 515.2 and 10476.2 and 521.1 and 10632.1 and 9551.3 and 522.3 or 4905.1 and 515.2 and 10476.2 and 521.1 and 10632.1 and 517.2 and 9551.2 and 522.3 or 10632.1 and 4905.1 and 10476.1 and 522.5 and 9551.2 and 518.2 and 521.1 and 515.1 or 4905.1 and 515.2 and 10476.2 and 516.2 and 521.1 and 10632.1 and 9551.3 and 522.5 or 518.3 and 4905.1 and 9551.1 and 515.2 and 10476.2 and 521.1 and 10632.1 and 522.4 or 10632.1 and 4905.1 and 10476.1 and 9551.1 and 522.2 and 515.2 and 518.2 and 521.1 or 518.3 and 10632.1 and 4905.1 and 10476.1 and 515.3 and 9551.2 and 522.4 and 521.1 or 10632.1 and 4905.1 and 10476.1 and 515.3 and 522.2 and 9551.3 and 518.2 and 521.1 or 4905.1 and 9551.1 and 10476.2 and 522…
is version of: http://identifiers.org/ec-code/3.6.3.14
is version of: http://identifiers.org/ec-code/3.6.1.14
reversible: false
kinetic law: MODEL1310110042#
modifier: MODEL1310110042#
type: Reaction
name: ATP synthase (four protons for one ATP)

metaR XYLUR
name: xylulose reductase
kinetic law: MODEL1310110042#
type: Reaction
product: MODEL1310110042#
reactant: MODEL1310110042#
modifier: MODEL1310110042#
is: SBO:0000176
reversible: true
notes: GENE_ASSOCIATION: (51181.1) SUBSYSTEM: Pentose phosphate pathway EC Number: 1.1.1.10 Confidence Level: 4 AUTHORS: PMID:11882650,PMID:6821187 NOTES:
is version of: http://identifiers.org/ec-code/1.1.1.10
fast: false
is described by: ECO:0000269

metaM nadph c
constant: false
is: C00005
type: Species
initial concentration: 1.0
is: HMDB00221
is: SBO:0000247
boundary condition: false
initial amount: NaN
notes: FORMULA: C21H26N7O17P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00015 EHMN_ABBREVIATION: C00005
has only substance units: false
name: Nicotinamide adenine dinucleotide phosphate - reduced
is: CHEBI:57783

http://identifiers.org/biomodels.db/MODEL1310110042#_f07272d1_3fba_4607_bd21_5c8732d1f0af
initial amount: NaN
boundary condition: true
name: CHAT
constant: false
type: Species
is: SBO:0000252
has only substance units: false
is encoded by: hsa:1103
initial concentration: NaN
is: Q6LEN5

http://identifiers.org/biomodels.db/MODEL1310110042#_31dcef57_72ec_4cfb_a2c6_f572402a709f
type: Species
constant: false
has only substance units: false
name: _AV713053_1_m
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:AV713053
boundary condition: true
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110042#_39773008_eade_4265_b4b2_893215c7e5b1
has part: P15954
has part: P12074
has part: P00414
has part: Q96KJ9
has part: Q8TF08
has part: P13073
has only substance units: false
is encoded by: hsa:4512
has part: Q6FGA0
has part: P14854
is encoded by: hsa:4513
is encoded by: hsa:1337
initial concentration: NaN
has part: Q53XN1
is encoded by: hsa:1349
is encoded by: hsa:1351
is encoded by: hsa:84701
has part: Q7GXY8
is encoded by: hsa:1329
is encoded by: hsa:170712
has part: P20674
is encoded by: hsa:125965
is encoded by: hsa:1345
has part: Q02221
has part: P24311
is encoded by: hsa:4514
has part: P09669
has part: H0UI06
has part: Q7Z4L0
is encoded by: hsa:1327
is encoded by: hsa:1340
has part: Q7GXZ8
type: Species
is encoded by: hsa:1339
is encoded by: hsa:1347
is encoded by: hsa:9377
initial amount: NaN
boundary condition: true
constant: false
is encoded by: hsa:341947
name: COX6B2:COX4I1:COX5B:COX6A1:COX6A2:COX6B1:COX6C:COX7A1:COX7A2:COX7B:COX7C:COX8A:COX7B2:COX8C:COX1:COX2:COX3:COX4I2:COX7A2L:COX5A
is: SBO:0000297
has part: P24310
is encoded by: hsa:9167
has part: Q6YFQ2
is encoded by: hsa:1346
is encoded by: hsa:1350
has part: Q53YB7

metaR COQ7m
product: MODEL1310110042#
fast: false
notes: GENE_ASSOCIATION: (10229.1) SUBSYSTEM: Ubiquinone synthesis EC Number: Confidence Level: 4 AUTHORS: PMID:11051212,PMID:1965190,PMID:7380842 NOTES:_1.14.13.- IT
kinetic law: MODEL1310110042#
type: Reaction
reversible: false
is: SBO:0000176
reactant: MODEL1310110042#
is described by: ECO:0000269
name: Ubiquinone biosynthesis COQ7
modifier: MODEL1310110042#

metaR SUCCtp
product: MODEL1310110042#
type: Reaction
fast: false
kinetic law: MODEL1310110042#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 0 AUTHORS: NOTES:unknown mechanism NJ
is described by: ECO:0000000
is: SBO:0000185
reactant: MODEL1310110042#
reversible: true
name: succinate transporter, peroxisome

metaR PPPGOm
is version of: http://identifiers.org/ec-code/1.3.3.4
is described by: ECO:0000304
name: protoporphyrinogen oxidase, mitochondrial
is: SBO:0000176
type: Reaction
reactant: MODEL1310110042#
kinetic law: MODEL1310110042#
notes: GENE_ASSOCIATION: (5498.1) SUBSYSTEM: Heme synthesis EC Number: 1.3.3.4 Confidence Level: 2 AUTHORS: PMID:8771201 NOTES:NCD
modifier: MODEL1310110042#
fast: false
reversible: false
product: MODEL1310110042#

metaR 10FTHFtm
reversible: true
type: Reaction
is described by: ECO:0000000
kinetic law: MODEL1310110042#
product: MODEL1310110042#
name: 10-Formyltetrahydrofolate mitochondrial transport via diffusion
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: PMID:11375437 NOTES:NCD
fast: false
reactant: MODEL1310110042#

http://identifiers.org/biomodels.db/MODEL1310110042#_8b10726f_0a75_48c1_8d73_e587677fda42
has only substance units: false
is: SBO:0000252
initial amount: NaN
constant: false
is encoded by: hsa:AI656480
boundary condition: true
name: _AI656480_1_m
type: Species
initial concentration: NaN

metaR r1556
product: MODEL1310110042#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
kinetic law: MODEL1310110042#
type: Reaction
is described by: ECO:0000000
is: SBO:0000185
reactant: MODEL1310110042#
reversible: true
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1

metaR H2O2t
is described by: ECO:0000000
type: Reaction
reactant: MODEL1310110042#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:2989289 NOTES:AMF
name: hydrogen peroxide transport via diffusion
reversible: true
fast: false
kinetic law: MODEL1310110042#
product: MODEL1310110042#
is: SBO:0000185

metaM perillyl e
boundary condition: false
is: HMDB03634
is: CHEBI:15420
initial concentration: 1.0
type: Species
constant: false
notes: FORMULA: C10H16O CHARGE: 0 INCHI: InChI=1S/C10H16O/c1-8(2)10-5-3-9(7-11)4-6-10/h3,10-11H,1,4-7H2,2H3 EHMN_ABBREVIATION: C02452
name: perillyl alcohol
initial amount: NaN
is: SBO:0000247
has only substance units: false

metaR MI14PP
is: SBO:0000176
name: inositol-1,4-bisphosphate 1-phosphatase
product: MODEL1310110042#
type: Reaction
notes: GENE_ASSOCIATION: (3628.1) SUBSYSTEM: Inositol phosphate metabolism EC Number: 3.1.3.61 Confidence Level: 4 AUTHORS: PMID:2906139,PMID:8390685 NOTES:NCD
reactant: MODEL1310110042#
kinetic law: MODEL1310110042#
is version of: http://identifiers.org/ec-code/3.1.3.57
is described by: ECO:0000269
fast: false
reversible: false
modifier: MODEL1310110042#

metaR EX htaxol LPAREN e RPAREN
kinetic law: MODEL1310110042#
reactant: MODEL1310110042#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: hydroxylated taxol exchange
type: Reaction

metaM o2 m
notes: FORMULA: O2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00017 EHMN_ABBREVIATION: C00007
is: C00007
is: CHEBI:15379
is: SBO:0000247
type: Species
is: HMDB01377
initial concentration: 1.0
name: O2
constant: false
boundary condition: false
has only substance units: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110042#_785e2aa7_8290_49bf_87b9_3f194a47999f
constant: false
name: CLYBL
is: SBO:0000252
type: Species
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:171425
has only substance units: false
boundary condition: true

metaR PGMT
reversible: true
is: SBO:0000176
is version of: http://identifiers.org/ec-code/5.4.2.2
is described by: ECO:0000134
product: MODEL1310110042#
type: Reaction
reactant: MODEL1310110042#
notes: GENE_ASSOCIATION: (5236.1) or (55276.1) SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: 5.4.2.2 Confidence Level: 0 AUTHORS: PMID:4829444 NOTES:
modifier: MODEL1310110042#
fast: false
kinetic law: MODEL1310110042#
name: phosphoglucomutase

metaM 4mzym int2 r
initial concentration: 1.0
has only substance units: false
type: Species
notes: FORMULA: C28H44O CHARGE: 0 INCHI: InChI=1/C28H44O/c1-18(2)8-7-9-19(3)22-12-13-24-21-10-11-23-20(4)26(29)15-17-28(23,6)25(21)14-16-27(22,24)5/h8,19-20,22-24H,7,9-17H2,1-6H3/t19-,20?,22?,23?,24?,27-,28+/m1/s1
is: HMDB06838
boundary condition: false
is: SBO:0000247
initial amount: NaN
constant: false
name: 4-Methylzymosterol intermediate 2

http://identifiers.org/biomodels.db/MODEL1310110042#_a2241aa1_a435_4fce_9a02_eeaab64dc71a
initial amount: NaN
constant: false
name: ALG6
type: Species
is: SBO:0000252
has only substance units: false
is encoded by: hsa:29929
boundary condition: true
is: Q9Y672
initial concentration: NaN

metaM cit c
is: HMDB00094
notes: FORMULA: C6H5O7 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00153 EHMN_ABBREVIATION: C00158
initial concentration: 1.0
has only substance units: false
is: C00158
name: Citrate
is: CHEBI:16947
type: Species
boundary condition: false
constant: false
initial amount: NaN
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110042#_39893bf9_8490_4913_b113_456e706f136f
has only substance units: false
initial amount: NaN
is: SBO:0000252
is: P21953
constant: false
type: Species
is encoded by: hsa:594
name: BCKDHB
initial concentration: NaN
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110042#_7475004b_e3c2_449a_85e1_0a6256e5e6c1
has only substance units: false
initial concentration: NaN
is: SBO:0000252
is: Q6IBK2
constant: false
boundary condition: true
name: KHK
initial amount: NaN
is encoded by: hsa:3795
type: Species

metaR r1557
reactant: MODEL1310110042#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
type: Reaction
product: MODEL1310110042#
is described by: ECO:0000000
fast: false
reversible: true
kinetic law: MODEL1310110042#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is: SBO:0000185

metaR r1143
kinetic law: MODEL1310110042#
name: Major Facilitator(MFS) TCDB:2.A.18.6.3
product: MODEL1310110042#
type: Reaction
reversible: false
is: SBO:0000185
reactant: MODEL1310110042#
fast: false
notes: GENE_ASSOCIATION: (788.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:10823827 NOTES:
modifier: MODEL1310110042#
is described by: ECO:0000000

metaR DM dttp m
kinetic law: MODEL1310110042#
reactant: MODEL1310110042#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 0 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: false
name: dTTP demand
type: Reaction

metaM dhcholestanate m
type: Species
constant: false
is: HMDB00359
initial amount: NaN
boundary condition: false
is: CHEBI:16577
name: 3alpha,7alpha-Dihydroxy-5beta-cholestanate
has only substance units: false
notes: FORMULA: C27H45O4 CHARGE: -1 INCHI: InChI=1S/C27H46O4/c1-16(6-5-7-17(2)25(30)31)20-8-9-21-24-22(11-13-27(20,21)4)26(3)12-10-19(28)14-18(26)15-23(24)29/h16-24,28-29H,5-15H2,1-4H3,(H,30,31)/t16-,17?,18+,19-,20-,21+,22+,23-,24+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01313 EHMN_ABBREVIATION: C04554
is: SBO:0000247
initial concentration: 1.0

metaM c51crn e
type: Species
name: tiglyl carnitine
is: HMDB02366
boundary condition: false
is: SBO:0000247
constant: false
notes: FORMULA: C12H21NO4 CHARGE: 0
initial concentration: 1.0
initial amount: NaN
has only substance units: false

metaM xolest2 hs e
initial concentration: 1.0
is: CHEBI:17002
has only substance units: false
is: SBO:0000247
notes: FORMULA: C27H45FULLR2CO2 CHARGE: 0
name: cholesterol ester
type: Species
boundary condition: false
constant: false
initial amount: NaN

metaR FAOXC61C4x
kinetic law: MODEL1310110042#
product: MODEL1310110042#
reactant: MODEL1310110042#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C6:1-->C4:0)x
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110042#_3fff0fca_3d99_4fd3_8051_b2af04021aae
is: P50213
boundary condition: true
initial concentration: NaN
initial amount: NaN
type: Species
constant: false
is encoded by: hsa:3419
has only substance units: false
name: IDH3A
is: SBO:0000252

metaR r1841
type: Reaction
is: SBO:0000185
name: Y+LAT2 Utilized transport
is described by: ECO:0000000
reactant: MODEL1310110042#
modifier: MODEL1310110042#
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
product: MODEL1310110042#
reversible: false
kinetic law: MODEL1310110042#
fast: false

metaR C4x
kinetic law: MODEL1310110042#
product: MODEL1310110042#
reactant: MODEL1310110042#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: esterification of butyrylcoa to butyrylcarnitine for transport
type: Reaction

metaR RE0452M
type: Reaction
product: MODEL1310110042#
is described by: ECO:0000000
reactant: MODEL1310110042#
kinetic law: MODEL1310110042#
name: RE0452
fast: false
is: SBO:0000176
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Pyrimidine synthesis EC Number: 2.7.4.9 Confidence Level: 0 AUTHORS: PMID:8024690 NOTES:

metaR O2St
name: superoxide anion transport via diffusion (extracellular)
is described by: ECO:0000000
reversible: true
reactant: MODEL1310110042#
product: MODEL1310110042#
kinetic law: MODEL1310110042#
type: Reaction
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:12939409 NOTES:
fast: false

metaM tetd7ecoa m
initial concentration: 1.0
constant: false
type: Species
name: 7-tetradecenoylcoa
has only substance units: false
boundary condition: false
initial amount: NaN
is: HMDB13109
notes: FORMULA: C35H56N7O17P3S CHARGE: -4
is: SBO:0000247

metaM anth e
type: Species
initial amount: NaN
is: HMDB01123
is: SBO:0000247
has only substance units: false
is: CHEBI:16567
name: anthranilate
boundary condition: false
constant: false
notes: FORMULA: C7H6NO2 CHARGE: -1 INCHI: InChI=1S/C7H7NO2/c8-6-4-2-1-3-5(6)7(9)10/h1-4H,8H2,(H,9,10)/p-1
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110042#_44c39bd5_6dae_43c4_8385_756b351c5f2a
type: Species
is: SBO:0000252
initial amount: NaN
has only substance units: false
initial concentration: NaN
boundary condition: true
is encoded by: hsa:6509
constant: false
name: SLC1A4
is: P43007

metaM perillyl c
is: SBO:0000247
boundary condition: false
is: CHEBI:15420
is: HMDB03634
initial concentration: 1.0
notes: FORMULA: C10H16O CHARGE: 0 INCHI: InChI=1S/C10H16O/c1-8(2)10-5-3-9(7-11)4-6-10/h3,10-11H,1,4-7H2,2H3 EHMN_ABBREVIATION: C02452
type: Species
name: perillyl alcohol
has only substance units: false
constant: false
initial amount: NaN

metaM mi134p c
boundary condition: false
has only substance units: false
is: HMDB01143
is: CHEBI:58414
name: 1D-myo-inositol 1,3,4-trisphosphate(6-)
constant: false
type: Species
is: SBO:0000247
initial amount: NaN
initial concentration: 1.0
notes: FORMULA: C6H9O15P3 CHARGE: -6 INCHI: InChI=1S/C6H15O15P3/c7-1-2(8)5(20-23(13,14)15)6(21-24(16,17)18)3(9)4(1)19-22(10,11)12/h1-9H,(H2,10,11,12)(H2,13,14,15)(H2,16,17,18)/p-6/t1-,2-,3+,4+,5+,6+/m1/s1 EHMN_ABBREVIATION: C01243

http://identifiers.org/biomodels.db/MODEL1310110042#_35bc3e83_a507_44a2_a08f_e16485e6fecc
is: SBO:0000252
type: Species
name: _LOC728997_1_c
constant: false
boundary condition: true
is encoded by: hsa:LOC728997
has only substance units: false
initial amount: NaN
initial concentration: NaN

metaR r0191
name: UTP:D-fructose-6-phosphate 1-phosphotransferase EC:2.7.1.11
kinetic law: MODEL1310110042#
reactant: MODEL1310110042#
is: SBO:0000176
is described by: ECO:0000000
modifier: MODEL1310110042#
fast: false
product: MODEL1310110042#
notes: GENE_ASSOCIATION: (7915.1) or (9856.1) SUBSYSTEM: Fructose and mannose metabolism EC Number: 2.7.1.11 Confidence Level: 0 AUTHORS: PMID:11945275,PMID:4276999 NOTES:
reversible: false
type: Reaction
is version of: http://identifiers.org/ec-code/1.2.1.24

http://identifiers.org/biomodels.db/MODEL1310110042#_923abb04_1085_4f93_a1c5_fa1e98a4c864
boundary condition: true
has only substance units: false
name: ACSL4
constant: false
is encoded by: hsa:2182
is: SBO:0000252
initial amount: NaN
initial concentration: NaN
type: Species
is: Q5JWV8

metaR r0475
name: 2-Deoxyadenosine 5-diphosphate:oxidized-thioredoxin 2-oxidoreductase Purine metabolism EC:1.17.4.1
kinetic law: MODEL1310110042#
is: SBO:0000176
reversible: true
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Nucleotide interconversion EC Number: 1.17.4.1 Confidence Level: 0 AUTHORS: PMID:6121703,PMID:8074691 NOTES:
product: MODEL1310110042#
type: Reaction
reactant: MODEL1310110042#
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110042#_415093ea_e16a_4860_8850_efc00bca8425
boundary condition: true
is encoded by: hsa:11320
has only substance units: false
initial concentration: NaN
is: E9PEN2
constant: false
is: SBO:0000252
initial amount: NaN
name: MGAT4A
type: Species

metaM cit e
constant: false
type: Species
is: SBO:0000247
initial concentration: 1.0
has only substance units: false
notes: FORMULA: C6H5O7 CHARGE: -3 INCHI: InChI=1S/C6H8O7/c7-3(8)1-6(13,5(11)12)2-4(9)10/h13H,1-2H2,(H,7,8)(H,9,10)(H,11,12)/p-3 HEPATONET_1.0_ABBREVIATION: HC00153 EHMN_ABBREVIATION: C00158
boundary condition: false
is: HMDB00094
initial amount: NaN
name: citrate(3-)
is: CHEBI:16947

metaR RE3244R
modifier: MODEL1310110042#
reversible: true
fast: false
reactant: MODEL1310110042#
is: SBO:0000176
kinetic law: MODEL1310110042#
name: RE3244
type: Reaction
product: MODEL1310110042#
notes: GENE_ASSOCIATION: (64834.1) SUBSYSTEM: Fatty acid synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:10970790 NOTES:
is described by: ECO:0000000

metaM hs deg13 l
type: Species
initial concentration: 1.0
constant: false
is: SBO:0000247
notes: FORMULA: C55H83N3O61S5 CHARGE: -6
is: CHEBI:17180
boundary condition: false
initial amount: NaN
is: HMDB01352
name: heparan sulfate, degradation product 13
has only substance units: false

metaR r1559
type: Reaction
is described by: ECO:0000000
fast: false
product: MODEL1310110042#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reversible: true
is: SBO:0000185
reactant: MODEL1310110042#
kinetic law: MODEL1310110042#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:

metaM ksi deg20 l
is: HMDB00143
notes: FORMULA: C138H223N9O119S6 CHARGE: -6
constant: false
type: Species
has only substance units: false
is: SBO:0000247
initial concentration: 1.0
is: CHEBI:12936
name: keratan sulfate I, degradation product 20
initial amount: NaN
boundary condition: false

metaM tmndnccoa x
initial amount: NaN
boundary condition: false
initial concentration: 1.0
has only substance units: false
constant: false
is: SBO:0000247
type: Species
notes: FORMULA: C41H60N7O17P3S CHARGE: -4 INCHI: InChI=1/C41H64N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-32(50)69-25-24-43-31(49)22-23-44-39(53)36(52)41(2,3)27-62-68(59,60)65-67(57,58)61-26-30-35(64-66(54,55)56)34(51)40(63-30)48-29-47-33-37(42)45-28-46-38(33)48/h5-6,8-9,11-12,14-15,17-18,28-30,34-36,40,51-52H,4,7,10,13,16,19-27H2,1-3H3,(H,43,49)(H,44,53)(H,57,58)(H,59,60)(H2,42,45,46)(H2,54,55,56)/b6-5-,9-8-,12-11-,15-14-,18-17-/t30-,34-,35?,36+,40-/m1/s1
name: timnodonyl coenzyme A
is: HMDB06514

http://identifiers.org/biomodels.db/MODEL1310110042#_cc96dc6a_2c3c_4307_8477_ceb233d51f60
has only substance units: false
name: SLC16A2
initial concentration: NaN
is: SBO:0000252
type: Species
constant: false
boundary condition: true
is encoded by: hsa:6567
initial amount: NaN
is: P36021

metaM dcacoa x
boundary condition: false
constant: false
is: HMDB06404
is: C05274
has only substance units: false
is: CHEBI:61430
is: SBO:0000247
initial concentration: 1.0
notes: FORMULA: C31H50N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC01413 EHMN_ABBREVIATION: C05274
type: Species
name: Decanoyl-CoA (n-C10:0CoA)
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110042#_91528e0b_cd07_47cb_9cd4_435ac9bbe32b
initial concentration: NaN
boundary condition: true
type: Species
initial amount: NaN
has only substance units: false
constant: false
is encoded by: hsa:AI769281
is: SBO:0000252
name: _AI769281_1_e

http://identifiers.org/biomodels.db/MODEL1310110042#_0e5651b3_1117_4040_9cfd_a57c5105bd7d
is encoded by: hsa:276
name: AMY1A
constant: false
type: Species
boundary condition: true
has only substance units: false
initial concentration: NaN
is: SBO:0000252
is: Q6NSB3
initial amount: NaN

metaM dec47dicoa m
is: http://identifiers.org/pubchem.compound/16019966
initial concentration: 1.0
boundary condition: false
notes: FORMULA: C31H46N7O17P3S CHARGE: -4
constant: false
initial amount: NaN
name: 4,7-decadienoylcoa
type: Species
has only substance units: false
is: SBO:0000247

metaR q10h2tc
kinetic law: MODEL1310110042#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: NOTES:
is described by: ECO:0000134
product: MODEL1310110042#
type: Reaction
is: SBO:0000185
reactant: MODEL1310110042#
name: transport of ubiquinol into cytosol
reversible: true
fast: false

http://identifiers.org/biomodels.db/MODEL1310110042#_5e4cfac8_25cb_4268_8d03_8fc961606378
is encoded by: hsa:3030
initial amount: NaN
initial concentration: NaN
type: Species
has only substance units: false
name: HADHA
constant: false
is: SBO:0000252
is: E9KL44
boundary condition: true

metaR r0732
name: Hexanoyl-CoA:acetyl-CoA C-acyltransferase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:2.3.1.16
kinetic law: MODEL1310110042#
is: SBO:0000176
product: MODEL1310110042#
reactant: MODEL1310110042#
fast: false
is described by: ECO:0000000
type: Reaction
reversible: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.16 Confidence Level: 0 AUTHORS: PMID:1121274,PMID:1679347,PMID:3194209,PMID:6378901,PMID:8241273 NOTES:

metaR ACOAO7p
fast: false
reactant: MODEL1310110042#
product: MODEL1310110042#
reversible: false
name: acyl-CoA oxidase (hexadecanoyl-CoA), peroxisomal
type: Reaction
is version of: http://identifiers.org/ec-code/1.3.3.6
kinetic law: MODEL1310110042#
modifier: MODEL1310110042#
is described by: ECO:0000269
is: SBO:0000176
notes: GENE_ASSOCIATION: (51.1) or (51.2) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.3.6 Confidence Level: 4 AUTHORS: PMID:7876265,PMID:8159712 NOTES:NCD

metaR r0627
reactant: MODEL1310110042#
name: Galactosylglycerol galactohydrolase Galactose metabolism EC:3.2.1.22 EC:3.2.1.23
is: SBO:0000176
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 3.2.1.23 Confidence Level: 0 AUTHORS: PMID:3569296 NOTES:
fast: false
kinetic law: MODEL1310110042#
is described by: ECO:0000000
type: Reaction
product: MODEL1310110042#

metaR RE0577C
notes: GENE_ASSOCIATION: (641372.1) or (641371.1) or (570.1) SUBSYSTEM: Fatty acid synthesis EC Number: 3.1.2.2 Confidence Level: 0 AUTHORS: PMID:10092594,PMID:10578051,PMID:16103133,PMID:16940157,PMID:9153233 NOTES:
modifier: MODEL1310110042#
reversible: true
kinetic law: MODEL1310110042#
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/2.3.1.65
type: Reaction
is version of: http://identifiers.org/ec-code/3.1.2.2
product: MODEL1310110042#
reactant: MODEL1310110042#
is: SBO:0000176
fast: false
name: RE0577

metaR EX dha LPAREN e RPAREN
kinetic law: MODEL1310110042#
reactant: MODEL1310110042#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of glycerone
type: Reaction

metaM mi145p c
notes: FORMULA: C6H9O15P3 CHARGE: -6 INCHI: InChI=1S/C6H15O15P3/c7-1-2(8)5(20-23(13,14)15)6(21-24(16,17)18)3(9)4(1)19-22(10,11)12/h1-9H,(H2,10,11,12)(H2,13,14,15)(H2,16,17,18)/p-6/t1-,2+,3+,4-,5-,6-/m1/s1 EHMN_ABBREVIATION: C01245
type: Species
initial concentration: 1.0
constant: false
boundary condition: false
is: CHEBI:203600
is: SBO:0000247
name: 1D-myo-inositol 1,4,5-trisphosphate(6-)
has only substance units: false
initial amount: NaN
is: HMDB01498

http://identifiers.org/biomodels.db/MODEL1310110042#_b6c73dee_0a75_486b_a1d5_b8a418c2e324
boundary condition: true
has only substance units: false
initial concentration: NaN
type: Species
constant: false
is: Q9H999
initial amount: NaN
is encoded by: hsa:79646
name: PANK3
is: SBO:0000252

metaM pmtcoa x
is: HMDB01338
boundary condition: false
initial concentration: 1.0
notes: FORMULA: C37H62N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00150 EHMN_ABBREVIATION: C00154
has only substance units: false
is: C00154
is: CHEBI:57379
is: SBO:0000247
name: Palmitoyl-CoA (n-C16:0CoA)
type: Species
initial amount: NaN
constant: false

metaR FAOXC163C142x
kinetic law: MODEL1310110042#
product: MODEL1310110042#
reactant: MODEL1310110042#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C16:3-->C14:2)x
type: Reaction

metaR PDE4n
is: SBO:0000176
name: 3',5'-cyclic-nucleotide phosphodiesterase, Nucleus
modifier: MODEL1310110042#
is described by: ECO:0000269
reactant: MODEL1310110042#
product: MODEL1310110042#
fast: false
type: Reaction
reversible: false
notes: GENE_ASSOCIATION: (5152.1) SUBSYSTEM: Nucleotide interconversion EC Number: 3.1.4.17 Confidence Level: 4 AUTHORS: PMID:12565835,PMID:14527714,PMID:9624146 NOTES:NCD. IT
is version of: http://identifiers.org/ec-code/3.1.4.35
kinetic law: MODEL1310110042#

metaR r0733
fast: false
product: MODEL1310110042#
name: (S)-Hydroxyhexanoyl-CoA:NAD+ oxidoreductase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:1.1.1.211 EC:1.1.1.35
is: SBO:0000176
modifier: MODEL1310110042#
notes: GENE_ASSOCIATION: (8659.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.1.1.35 Confidence Level: 0 AUTHORS: PMID:10231530,PMID:10329704,PMID:1550553,PMID:1651711,PMID:7150615,PMID:8188243,PMID:8687463,PMID:9553139 NOTES:
reversible: false
is described by: ECO:0000000
type: Reaction
is version of: http://identifiers.org/ec-code/1.5.1.12
kinetic law: MODEL1310110042#
reactant: MODEL1310110042#

metaM b2coa m
name: crotonoyl-CoA(4-)
is: HMDB02009
is: CHEBI:57332
initial concentration: 1.0
has only substance units: false
boundary condition: false
type: Species
constant: false
notes: FORMULA: C25H36N7O17P3S CHARGE: -4 INCHI: InChI=1S/C25H40N7O17P3S/c1-4-5-16(34)53-9-8-27-15(33)6-7-28-23(37)20(36)25(2,3)11-46-52(43,44)49-51(41,42)45-10-14-19(48-50(38,39)40)18(35)24(47-14)32-13-31-17-21(26)29-12-30-22(17)32/h4-5,12-14,18-20,24,35-36H,6-11H2,1-3H3,(H,27,33)(H,28,37)(H,41,42)(H,43,44)(H2,26,29,30)(H2,38,39,40)/p-4/b5-4+/t14-,18-,19-,20+,24-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00572 EHMN_ABBREVIATION: C00877
initial amount: NaN
is: SBO:0000247

metaR EX dmhptcrn LPAREN e RPAREN
kinetic law: MODEL1310110042#
reactant: MODEL1310110042#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 2,6 dimethylheptanoyl carnitine exchange
type: Reaction

metaR DCSPTN1t
kinetic law: MODEL1310110042#
type: Reaction
reactant: MODEL1310110042#
is described by: ECO:0000000
product: MODEL1310110042#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11788354,PMID:12864740 NOTES:NJ
is: SBO:0000185
name: fatty acid transport via diffusion
fast: false
reversible: true

metaM ha e
is: SBO:0000247
initial amount: NaN
boundary condition: false
has only substance units: false
constant: false
notes: FORMULA: C28H40N2O22 CHARGE: -2 EHMN_ABBREVIATION: C00518
initial concentration: 1.0
type: Species
name: hyaluronan
is: CHEBI:16336

http://identifiers.org/biomodels.db/MODEL1310110042#_02385aa6_19b1_4b22_92bb_1f501d59e680
boundary condition: true
is encoded by: hsa:57835
initial concentration: NaN
name: SLC4A5
initial amount: NaN
has only substance units: false
constant: false
type: Species
is: SBO:0000252

metaR P45011A1m
kinetic law: MODEL1310110042#
is version of: http://identifiers.org/ec-code/1.14.15.6
name: Cytochrome P450 11A1, mitochondrial [Precursor]
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (1583.1) SUBSYSTEM: Steroid metabolism EC Number: 1.14.15.67 Confidence Level: 4 AUTHORS: PMID:16232916 NOTES:reaction sequence mx steps, grouped into single reaction uses adrenal ferredoxin NJ
is: SBO:0000176
fast: false
modifier: MODEL1310110042#
product: MODEL1310110042#
type: Reaction
reversible: false
reactant: MODEL1310110042#

metaR NDPK6m
reversible: true
is: SBO:0000176
reactant: MODEL1310110042#
modifier: MODEL1310110042#
type: Reaction
fast: false
notes: GENE_ASSOCIATION: (4833.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.6 Confidence Level: 2 AUTHORS: PMID:9099850 NOTES:Many nucleoside diphosphates (eight described) can act as acceptors. While many ribo- and deoxyribonucleoside triphosphates can act as donors, only ATP is chosen as a donor to minimize the number of total reactions.
is version of: http://identifiers.org/ec-code/2.7.4.6
name: nucleoside-diphosphate kinase (ATP:dUDP), mitochondrial
is described by: ECO:0000254
product: MODEL1310110042#
kinetic law: MODEL1310110042#

metaR HEXDCRNe
kinetic law: MODEL1310110042#
product: MODEL1310110042#
reactant: MODEL1310110042#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of 3-hydroxyhexadecanoyl carnitine into extra cellular space
type: Reaction

metaM acnam c
has only substance units: false
name: N-acetylneuraminate
initial concentration: 1.0
is: CHEBI:35418
type: Species
boundary condition: false
notes: FORMULA: C11H18NO9 CHARGE: -1 INCHI: InChI=1S/C11H19NO9/c1-4(14)12-7-5(15)2-11(20,10(18)19)21-9(7)8(17)6(16)3-13/h5-9,13,15-17,20H,2-3H2,1H3,(H,12,14)(H,18,19)/p-1/t5-,6+,7+,8+,9+,11?/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00244 EHMN_ABBREVIATION: C00270
initial amount: NaN
is: HMDB00230
constant: false
is: SBO:0000247

metaM 3bcrn e
is: C14143
has only substance units: false
is: HMDB04047
constant: false
type: Species
boundary condition: false
notes: FORMULA: C11H21NO5 CHARGE: 0
is: SBO:0000247
initial concentration: 1.0
name: 3-hydroxy butyryl carnitine
initial amount: NaN

metaR EX ocdca LPAREN e RPAREN
kinetic law: MODEL1310110042#
reactant: MODEL1310110042#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: echange reaction for octadecanoate (n-C18:0)
type: Reaction

metaR VITD3t2
product: MODEL1310110042#
name: Vitamin D3 uptake
type: Reaction
is described by: ECO:0000000
fast: false
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:I am not sure how vitamin D3 is taken up from peripheral cells based on Vitamins, G.F.M. Ball,2004, Blackwell publishing, 1st ed (book) pg.193 IT
reversible: false
reactant: MODEL1310110042#
kinetic law: MODEL1310110042#

http://identifiers.org/biomodels.db/MODEL1310110042#_f21be94b_fe92_4e71_a387_2d7996264133
is encoded by: hsa:1809
initial concentration: NaN
type: Species
initial amount: NaN
constant: false
is: Q8IXW6
name: DPYSL3
has only substance units: false
is: SBO:0000252
boundary condition: true

metaR PFK
product: MODEL1310110042#
kinetic law: MODEL1310110042#
is described by: ECO:0000304
reversible: false
notes: GENE_ASSOCIATION: (5214.1) or (5211.2) or (5214.1 and 5211.1) or (5214.1 and 5213.1) or (5213.1) or (5214.1 and 5211.2) or (5211.1) or (5211.1 and 5213.1) or (5213.1 and 5211.2) SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: Confidence Level: 2 AUTHORS: NOTES:
is version of: http://identifiers.org/ec-code/2.7.1.11
is: SBO:0000176
modifier: MODEL1310110042#
type: Reaction
name: phosphofructokinase
fast: false
reactant: MODEL1310110042#

metaR C226COAtx
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: NOTES:interaction between peroxisomes and ER (some enzymes on the outer membrane) NJ
is: SBO:0000185
reactant: MODEL1310110042#
fast: false
kinetic law: MODEL1310110042#
type: Reaction
product: MODEL1310110042#
reversible: true
is described by: ECO:0000000
name: fatty acid intracellular transport

metaR r2511
name: Utilized transport
fast: false
is described by: ECO:0000000
is: SBO:0000185
kinetic law: MODEL1310110042#
product: MODEL1310110042#
reactant: MODEL1310110042#
reversible: true
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:17466261 NOTES:

metaM m6masnB2 g
constant: false
boundary condition: false
notes: FORMULA: C58H97N2O45X CHARGE: 0
initial amount: NaN
is: CHEBI:30825
name: (alpha-D-mannosyl)6-beta-D-mannosyl-diacetylchitobiosyl-L-asparagine (protein)
is: HMDB00573
is: SBO:0000247
initial concentration: 1.0
type: Species
has only substance units: false

metaR PI4P3K
product: MODEL1310110042#
reversible: false
name: phosphatidylinositol 4-phosphate 3-kinase
is version of: http://identifiers.org/ec-code/2.7.11.1
is: SBO:0000176
reactant: MODEL1310110042#
is described by: ECO:0000000
modifier: MODEL1310110042#
notes: GENE_ASSOCIATION: (5291.1 and 5295.3) or (5296.1 and 5290.1) or (5293.1 and 5296.1) or (5287.1) or (5286.1) or (5293.1 and 8503.1) or (5293.1 and 5295.3) or (5291.1 and 8503.1) or (5295.2 and 5290.1) or (5288.1) or (5291.1 and 5295.1) or (5296.1 and 5291.1) or (23533.1 and 5294.1) or (5293.1 and 5295.1) or (5295.2 and 5293.1) or (5290.1 and 8503.1) or (5290.1 and 5295.3) or (10870.1 and 5294.1) or (5295.2 and 5291.1) or (5290.1 and 5295.1) SUBSYSTEM: Inositol phosphate metabolism EC Number: 2.7.1.68 Confidence Level: 4 AUTHORS: PMID:7624799,PMID:7713498,PMID:8246984,PMID:9113989,PMID:9337861,PMID:9830063,PMID:9878262 NOTES:NCD Notice that contrary to some standards in texts, KEGG, etc, the Rtotal group accounts for the whole fatty acyl CoA (so the CHO only accounts for the core backbone), manner in which Rtotal was produced accounts for O and H balances. Formation of the Rtotal group (rxn flux)accounted for mass balance for CoA NJ changed EC from 2.7.1.149 (pail5p) to 2.7.1.68 (pail4p) - NCD
is version of: http://identifiers.org/ec-code/2.7.1.154
fast: false
is version of: http://identifiers.org/ec-code/2.7.1.153
kinetic law: MODEL1310110042#
type: Reaction

metaR r0730
reactant: MODEL1310110042#
product: MODEL1310110042#
is version of: http://identifiers.org/ec-code/1.3.99.3
is: SBO:0000176
kinetic law: MODEL1310110042#
name: (S)-Hydroxyoctanoyl-CoA:NAD+ oxidoreductase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:1.1.1.211
notes: GENE_ASSOCIATION: (34.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.1.1.211 Confidence Level: 0 AUTHORS: PMID:10231530,PMID:10329704,PMID:1550553,PMID:1651711,PMID:7150615,PMID:8188243,PMID:8687463,PMID:9553139 NOTES:
is described by: ECO:0000000
type: Reaction
modifier: MODEL1310110042#
reversible: false
fast: false

metaR FOAXC122C101x
kinetic law: MODEL1310110042#
product: MODEL1310110042#
reactant: MODEL1310110042#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C12:2-->C10:1)x
type: Reaction

metaR CITL
modifier: MODEL1310110042#
reactant: MODEL1310110042#
fast: false
notes: GENE_ASSOCIATION: (171425.1) or (171425.2) SUBSYSTEM: Citric acid cycle EC Number: 4.1.3.6 Confidence Level: 0 AUTHORS: PMID:11741334 NOTES:JLR
reversible: false
name: Citrate lyase
type: Reaction
kinetic law: MODEL1310110042#
is described by: ECO:0000000
product: MODEL1310110042#
is: SBO:0000176

metaM cspg a e
constant: false
is: HMDB00630
boundary condition: false
name: chondroitin sulfate A (GalNAc4S-GlcA) proteoglycan
has only substance units: false
initial amount: NaN
is: SBO:0000247
is: CHEBI:16040
type: Species
initial concentration: 1.0
notes: FORMULA: C45H66N2O45S3X CHARGE: -5

metaR EX ttdca LPAREN e RPAREN
kinetic law: MODEL1310110042#
reactant: MODEL1310110042#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for tetradecanoate (n-C14:0)
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110042#_1f66f230_9150_4c6c_ae45_2e73aa13c509
name: _D87002_1_e
is: SBO:0000252
initial amount: NaN
has only substance units: false
boundary condition: true
initial concentration: NaN
constant: false
is encoded by: hsa:D87002
type: Species

http://identifiers.org/biomodels.db/MODEL1310110042#_930ed8bc_6d29_4bb7_a198_6fe106e2d54c
has only substance units: false
initial concentration: NaN
is encoded by: hsa:8398
boundary condition: true
constant: false
initial amount: NaN
type: Species
is: A8K460
is: SBO:0000252
name: PLA2G6

http://identifiers.org/biomodels.db/MODEL1310110042#_0ecd99fd_13df_4985_b86c_51fed1413dc9
initial concentration: NaN
is: Q99808
is: SBO:0000252
boundary condition: true
is encoded by: hsa:2030
constant: false
type: Species
name: SLC29A1
has only substance units: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110042#_e07a2518_3848_4b1e_ab17_9a4a72f08d6f
type: Species
is encoded by: hsa:7001
constant: false
initial amount: NaN
initial concentration: NaN
has only substance units: false
name: PRDX2
is: SBO:0000252
boundary condition: true

metaM ade c
is: C00147
boundary condition: false
has only substance units: false
notes: FORMULA: C5H5N5 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00144 EHMN_ABBREVIATION: C00147
name: Adenine
initial concentration: 1.0
is: CHEBI:16708
initial amount: NaN
is: SBO:0000247
constant: false
is: HMDB00034
type: Species

metaM tmndnccoa m
initial amount: NaN
notes: FORMULA: C41H60N7O17P3S CHARGE: -4 INCHI: InChI=1/C41H64N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-32(50)69-25-24-43-31(49)22-23-44-39(53)36(52)41(2,3)27-62-68(59,60)65-67(57,58)61-26-30-35(64-66(54,55)56)34(51)40(63-30)48-29-47-33-37(42)45-28-46-38(33)48/h5-6,8-9,11-12,14-15,17-18,28-30,34-36,40,51-52H,4,7,10,13,16,19-27H2,1-3H3,(H,43,49)(H,44,53)(H,57,58)(H,59,60)(H2,42,45,46)(H2,54,55,56)/b6-5-,9-8-,12-11-,15-14-,18-17-/t30-,34-,35?,36+,40-/m1/s1
is: SBO:0000247
boundary condition: false
type: Species
is: HMDB06514
initial concentration: 1.0
name: timnodonyl coenzyme A
constant: false
has only substance units: false

metaM cs a deg1 l
name: chondroitin sulfate A (GalNAc4S-GlcA), degradation product 1
is: SBO:0000247
initial concentration: 1.0
has only substance units: false
type: Species
initial amount: NaN
notes: FORMULA: C45H68N2O43S2 CHARGE: -4
is: CHEBI:16953
is: HMDB00812
constant: false
boundary condition: false

metaR EX sprm LPAREN e RPAREN
kinetic law: MODEL1310110042#
reactant: MODEL1310110042#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: PMID:10049700,PMID:10574970,PMID:11389679,PMID:11557028,PMID:11564694,PMID:12824232,PMID:12930836,PMID:14574404,PMID:16288981,PMID:911815 NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: EX_sprm(e)
type: Reaction

metaR GLNALANaEx
type: Reaction
name: L-alanine/L-glutamine Na-dependent exchange (Gln-L in)
product: MODEL1310110042#
modifier: MODEL1310110042#
fast: false
reversible: false
notes: GENE_ASSOCIATION: (6510.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14530974 NOTES:SAB see Kanai and Hediger 2004 (2003), PMID 14530974
is: SBO:0000185
reactant: MODEL1310110042#
is described by: ECO:0000269
kinetic law: MODEL1310110042#

metaM amet m
type: Species
has only substance units: false
name: S-Adenosyl-L-methionine
constant: false
initial amount: NaN
boundary condition: false
is: C00019
notes: FORMULA: C15H23N6O5S CHARGE: 1 HEPATONET_1.0_ABBREVIATION: HC00029 EHMN_ABBREVIATION: C00019
is: CHEBI:15414
is: SBO:0000247
is: HMDB01185
initial concentration: 1.0

metaR FAOXC184m
kinetic law: MODEL1310110042#
product: MODEL1310110042#
reactant: MODEL1310110042#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: isomerization of (C18:4)m
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110042#_1aad0f46_fdc7_4eef_9ee3_6a5de94a31e6
constant: false
is: Q6P9G0
name: CYB5D1
is encoded by: hsa:124637
has only substance units: false
type: Species
is: SBO:0000252
initial concentration: NaN
initial amount: NaN
boundary condition: true

metaR r0731
product: MODEL1310110042#
fast: false
reactant: MODEL1310110042#
reversible: false
is: SBO:0000176
name: (S)-Hydroxyoctanoyl-CoA hydro-lyase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:4.2.1.17
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.17 Confidence Level: 0 AUTHORS: PMID:8012501,PMID:8188243 NOTES:
type: Reaction
is described by: ECO:0000000
kinetic law: MODEL1310110042#

metaR PYDXNtr
is: SBO:0000185
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:6380540 NOTES:IT
name: pyridoxine transport via diffusion
type: Reaction
reversible: true
reactant: MODEL1310110042#
product: MODEL1310110042#
fast: false
kinetic law: MODEL1310110042#

metaM ade e
has only substance units: false
initial concentration: 1.0
constant: false
is: SBO:0000247
is: CHEBI:16708
initial amount: NaN
notes: FORMULA: C5H5N5 CHARGE: 0 INCHI: InChI=1S/C5H5N5/c6-4-3-5(9-1-7-3)10-2-8-4/h1-2H,(H3,6,7,8,9,10) HEPATONET_1.0_ABBREVIATION: HC00144 EHMN_ABBREVIATION: C00147
boundary condition: false
type: Species
name: adenine
is: HMDB00034

metaR EX CE5868 LPAREN e RPAREN
kinetic law: MODEL1310110042#
reactant: MODEL1310110042#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: N-acetyl-seryl-aspartate exchange
type: Reaction

metaR EX acetone LPAREN e RPAREN
kinetic law: MODEL1310110042#
reactant: MODEL1310110042#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Acetone exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110042#_f275df52_8b90_484a_96d6_72d9ba49cdef
type: Species
is encoded by: hsa:3037
initial concentration: NaN
initial amount: NaN
name: HAS2
is: SBO:0000252
is: Q92819
boundary condition: true
constant: false
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110042#_02c215df_ad0c_477e_81d2_ffd427a69c74
type: Species
initial amount: NaN
name: _AI024818_1_c
is encoded by: hsa:AI024818
initial concentration: NaN
constant: false
is: SBO:0000252
boundary condition: true
has only substance units: false

metaR FAOXC180
is described by: ECO:0000269
name: Beta oxidation of long chain fatty acid
product: MODEL1310110042#
kinetic law: MODEL1310110042#
notes: GENE_ASSOCIATION: (34.1) or (34.1) or (35.1) or (35.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.99.3 Confidence Level: 4 AUTHORS: PMID:2565344,PMID:3035565 NOTES:TV Other enzymes: 1.3.3.6, 4.2.1.74, 4.2.1.17, 1.1.1.35, 1.1.1.211
fast: false
type: Reaction
modifier: MODEL1310110042#
is version of: http://identifiers.org/ec-code/1.3.99.3
reversible: false
reactant: MODEL1310110042#
is version of: http://identifiers.org/ec-code/1.3.8.1
is: SBO:0000176

metaR r2030
type: Reaction
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
kinetic law: MODEL1310110042#
modifier: MODEL1310110042#
reactant: MODEL1310110042#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.15
fast: false
reversible: false
product: MODEL1310110042#
is: SBO:0000185
is described by: ECO:0000000

metaM nadph x
is: CHEBI:57783
name: Nicotinamide adenine dinucleotide phosphate - reduced
is: C00005
type: Species
constant: false
is: SBO:0000247
is: HMDB00221
has only substance units: false
initial concentration: 1.0
initial amount: NaN
boundary condition: false
notes: FORMULA: C21H26N7O17P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00015 EHMN_ABBREVIATION: C00005

metaM ksi pre31 g
constant: false
initial concentration: 1.0
is: HMDB00175
initial amount: NaN
boundary condition: false
is: SBO:0000247
is: CHEBI:58053
has only substance units: false
type: Species
name: keratan sulfate I biosynthesis, precursor 31
notes: FORMULA: C227H363N16O189S9X CHARGE: -10
is: C00130

metaR 2MB2COAc
kinetic law: MODEL1310110042#
product: MODEL1310110042#
reactant: MODEL1310110042#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: transport of 2-methylcrotonoyl-CoA into cytosol
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110042#_0c1236a4_b65e_4a05_9170_2af832324057
has only substance units: false
is: P23434
is encoded by: hsa:2653
initial concentration: NaN
initial amount: NaN
constant: false
name: GCSH
boundary condition: true
is: SBO:0000252
type: Species

metaR r2514
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:17466261 NOTES:
kinetic law: MODEL1310110042#
reversible: true
reactant: MODEL1310110042#
is: SBO:0000185
name: Utilized transport
type: Reaction
fast: false
product: MODEL1310110042#
is described by: ECO:0000000

metaM lnlncg c
initial amount: NaN
name: gamma-linolenate
is: CHEBI:32391
has only substance units: false
initial concentration: 1.0
boundary condition: false
type: Species
is: SBO:0000247
constant: false
notes: FORMULA: C18H29O2 CHARGE: -1 INCHI: InChI=1S/C18H30O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20/h6-7,9-10,12-13H,2-5,8,11,14-17H2,1H3,(H,19,20)/p-1/b7-6-,10-9-,13-12-
is: HMDB03073

http://identifiers.org/biomodels.db/MODEL1310110042#_474f0cc8_eafc_43a1_b0a4_d32b3b6ad49f
type: Species
constant: false
is encoded by: hsa:518
has only substance units: false
name: ATP5G3
is: SBO:0000252
initial amount: NaN
boundary condition: true
initial concentration: NaN

metaR GLCtg
reversible: true
notes: GENE_ASSOCIATION: (6513.1) SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 4 AUTHORS: PMID:15384581 NOTES:NCD
is: SBO:0000185
is described by: ECO:0000269
type: Reaction
product: MODEL1310110042#
fast: false
reactant: MODEL1310110042#
modifier: MODEL1310110042#
name: glucose transport, Golgi apparatus
kinetic law: MODEL1310110042#

metaM HC01401 x
is: CHEBI:27668
notes: FORMULA: C33H54N7O18P3S CHARGE: -4 INCHI: InChI=1S/C33H58N7O18P3S/c1-4-5-6-7-8-9-10-11-21(41)16-24(43)62-15-14-35-23(42)12-13-36-31(46)28(45)33(2,3)18-55-61(52,53)58-60(50,51)54-17-22-27(57-59(47,48)49)26(44)32(56-22)40-20-39-25-29(34)37-19-38-30(25)40/h19-22,26-28,32,41,44-45H,4-18H2,1-3H3,(H,35,42)(H,36,46)(H,50,51)(H,52,53)(H2,34,37,38)(H2,47,48,49)/t21-,22+,26+,27+,28-,32+/m0/s1 EHMN_ABBREVIATION: C05262
initial concentration: 1.0
type: Species
constant: false
initial amount: NaN
is: SBO:0000247
name: (S)-3-Hydroxydodecanoyl-CoA
boundary condition: false
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110042#_7d91e420_3b31_4f88_bc9d_4fac16a0fed1
is: SBO:0000252
type: Species
name: GLRX2
initial amount: NaN
has only substance units: false
constant: false
initial concentration: NaN
is encoded by: hsa:51022
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110042#_861376e5_e4d5_4c9a_8027_661656d55660
has only substance units: false
is encoded by: hsa:3163
initial amount: NaN
initial concentration: NaN
is: P30519
is: SBO:0000252
boundary condition: true
constant: false
name: HMOX2
type: Species

metaM C05279 m
has only substance units: false
name: trans,cis-Lauro-2,6-dienoyl-CoA
type: Species
constant: false
is: HMDB11123
initial amount: NaN
initial concentration: 1.0
notes: FORMULA: C33H50N7O17P3S CHARGE: -4 INCHI: InChI=1S/C33H54N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-24(42)61-17-16-35-23(41)14-15-36-31(45)28(44)33(2,3)19-54-60(51,52)57-59(49,50)53-18-22-27(56-58(46,47)48)26(43)32(55-22)40-21-39-25-29(34)37-20-38-30(25)40/h8-9,12-13,20-22,26-28,32,43-44H,4-7,10-11,14-19H2,1-3H3,(H,35,41)(H,36,45)(H,49,50)(H,51,52)(H2,34,37,38)(H2,46,47,48)/b9-8-,13-12+/t22-,26-,27-,28+,32-/m1/s1 EHMN_ABBREVIATION: C05279
is: CHEBI:28387
boundary condition: false
is: SBO:0000247

metaR EX dag hs LPAREN e RPAREN
kinetic law: MODEL1310110042#
reactant: MODEL1310110042#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for diglyceride
type: Reaction

metaR C226CPT1
is version of: http://identifiers.org/ec-code/2.3.1.21
is described by: ECO:0000000
is: SBO:0000176
reversible: false
product: MODEL1310110042#
notes: GENE_ASSOCIATION: (126129.1) or (1375.3) or (1374.1) or (1375.2) or (1375.1) or (1375.4) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.21 Confidence Level: 4 AUTHORS: PMID:1988962 NOTES:TDV
fast: false
type: Reaction
kinetic law: MODEL1310110042#
name: carnitine C22:6 transferase
reactant: MODEL1310110042#
modifier: MODEL1310110042#

metaM 5hoxindoa c
name: 5-Hydroxyindoleacetate
boundary condition: false
is: CHEBI:27823
has only substance units: false
notes: FORMULA: C10H8NO3 CHARGE: -1 INCHI: InChI=1S/C10H9NO3/c12-7-1-2-9-8(4-7)6(5-11-9)3-10(13)14/h1-2,4-5,11-12H,3H2,(H,13,14) HEPATONET_1.0_ABBREVIATION: HC01537 EHMN_ABBREVIATION: C05635
initial concentration: 1.0
is: HMDB00763
initial amount: NaN
constant: false
is: SBO:0000247
type: Species

metaR ALAGLNexR
notes: GENE_ASSOCIATION: (6520.1) and (56301.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10734121,PMID:10863037,PMID:14770310 NOTES:
type: Reaction
fast: false
is described by: ECO:0000304
reversible: true
name: L-alanine/glutamine reversible exchange
reactant: MODEL1310110042#
product: MODEL1310110042#
is: SBO:0000185
modifier: MODEL1310110042#
kinetic law: MODEL1310110042#

http://identifiers.org/biomodels.db/MODEL1310110042#_187965f0_6a53_4cca_87ab_7a72605e76c7
is encoded by: hsa:29920
initial amount: NaN
has only substance units: false
type: Species
is: Q96C36
name: PYCR2
initial concentration: NaN
is: SBO:0000252
boundary condition: true
constant: false

metaM 4hglusa m
constant: false
initial amount: NaN
is: CHEBI:27809
is: SBO:0000247
name: L-4-hydroxyglutamic semialdehyde
type: Species
notes: FORMULA: C5H9NO4 CHARGE: 0 INCHI: InChI=1S/C5H9NO4/c6-4(5(9)10)1-3(8)2-7/h2-4,8H,1,6H2,(H,9,10)/t3-,4+/m1/s1 EHMN_ABBREVIATION: C05938
is: HMDB06556
has only substance units: false
boundary condition: false
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110042#_53bc07c1_3af8_40ed_b662_7dc96cb9921b
has only substance units: false
boundary condition: true
initial amount: NaN
name: PKM2
is encoded by: hsa:5315
constant: false
type: Species
is: SBO:0000252
initial concentration: NaN

metaR GCCbim
is version of: http://identifiers.org/ec-code/1.4.4.2
reactant: MODEL1310110042#
is version of: http://identifiers.org/ec-code/1.8.1.4
kinetic law: MODEL1310110042#
is: SBO:0000176
notes: GENE_ASSOCIATION: (275.1) and (1738.1) and (2731.1) and (2653.1) SUBSYSTEM: Glycine, serine, alanine and threonine metabolism EC Number: 1.8.1.4 Confidence Level: 4 AUTHORS: PMID:15355973 NOTES:NCD
is version of: http://identifiers.org/ec-code/2.1.2.10
reversible: false
modifier: MODEL1310110042#
type: Reaction
name: glycine-cleavage complex (lipoylprotein) irreversible, mitochondrial
fast: false
product: MODEL1310110042#
is described by: ECO:0000269

metaR r0629
reversible: true
product: MODEL1310110042#
kinetic law: MODEL1310110042#
is version of: http://identifiers.org/ec-code/3.1.4.1
is version of: http://identifiers.org/ec-code/3.6.1.22
is: SBO:0000176
reactant: MODEL1310110042#
is described by: ECO:0000000
type: Reaction
name: Choloyl-CoA:glycine N-choloyltransferase Bile acid biosynthesis / Taurine and hypotaurine metabolism EC:2.3.1.65
modifier: MODEL1310110042#
fast: false
notes: GENE_ASSOCIATION: (AI926493.1) or (5167.1) or (5169.1) or (83594.1) SUBSYSTEM: Bile acid synthesis EC Number: 2.3.1.65 Confidence Level: 0 AUTHORS: PMID:10884298,PMID:12239217,PMID:12543708,PMID:15026425,PMID:3741411,PMID:6884990 NOTES:

metaR NDPK6n
reactant: MODEL1310110042#
fast: false
is version of: http://identifiers.org/ec-code/2.7.4.6
reversible: true
name: nucleoside-diphosphate kinase (ATP:dUDP), nuclear
modifier: MODEL1310110042#
is: SBO:0000176
kinetic law: MODEL1310110042#
type: Reaction
notes: GENE_ASSOCIATION: (4831.1 and 4830.1) or (4830.2 and 4831.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.6 Confidence Level: 4 AUTHORS: PMID:7050910 NOTES:Many nucleoside diphosphates (eight described) can act as acceptors. While many ribo- and deoxyribonucleoside triphosphates can act as donors, only ATP is chosen as a donor to minimize the number of total reactions.. Presence in the nucleus
product: MODEL1310110042#
is described by: ECO:0000304

metaR CHOLtu
modifier: MODEL1310110042#
fast: false
type: Reaction
name: Choline uniport
notes: GENE_ASSOCIATION: (6582.1) or (6584.1) or (6582.2) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12883891 NOTES:SAB electrogenic, Na indepdendent & rev
product: MODEL1310110042#
is described by: ECO:0000269
reactant: MODEL1310110042#
kinetic law: MODEL1310110042#
reversible: true
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110042#_75e40a46_7dc4_4bb2_aaa5_61747a84403a
is encoded by: hsa:8574
has only substance units: false
is: SBO:0000252
boundary condition: true
type: Species
constant: false
initial amount: NaN
name: AKR7A2
initial concentration: NaN
is: O43488

metaR FAOXC142C142OHm
kinetic law: MODEL1310110042#
product: MODEL1310110042#
reactant: MODEL1310110042#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C14:2-->C14:2OH)m
type: Reaction

metaR CHAT
is described by: ECO:0000269
reactant: MODEL1310110042#
product: MODEL1310110042#
is: SBO:0000176
name: Choline O-acetyltransferase
is version of: http://identifiers.org/ec-code/2.3.1.6
notes: GENE_ASSOCIATION: (1103.4) or (1103.2) or (1103.3) or (1103.1) SUBSYSTEM: Glycerophospholipid metabolism EC Number: 2.3.1.6 Confidence Level: 4 AUTHORS: PMID:10861222 NOTES:rev by uniprot NJ
fast: false
kinetic law: MODEL1310110042#
reversible: true
type: Reaction
modifier: MODEL1310110042#

metaM fn2m2masn g
notes: FORMULA: C56H93N4O39X CHARGE: 0 INCHI: InChI=1S/C60H100N6O42/c1-14-32(77)42(87)45(90)57(96-14)94-13-26-48(40(85)28(62-15(2)72)52(97-26)66-27(76)6-19(61)53(92)93)104-56-31(65-18(5)75)41(86)47(24(11-71)102-56)105-58-46(91)49(106-60-51(44(89)36(81)23(10-70)101-60)108-55-30(64-17(4)74)39(84)34(79)21(8-68)99-55)37(82)25(103-58)12-95-59-50(43(88)35(80)22(9-69)100-59)107-54-29(63-16(3)73)38(83)33(78)20(7-67)98-54/h14,19-26,28-52,54-60,67-71,77-91H,6-13,61H2,1-5H3,(H,62,72)(H,63,73)(H,64,74)(H,65,75)(H,66,76)(H,92,93)/t14-,19-,20+,21+,22+,23+,24+,25+,26+,28+,29+,30+,31+,32+,33+,34+,35+,36+,37+,38+,39+,40+,41+,42+,43-,44-,45-,46-,47+,48+,49-,50-,51-,52+,54-,55-,56-,57+,58-,59-,60+/m0/s1
constant: false
initial amount: NaN
has only substance units: false
initial concentration: 1.0
is: SBO:0000247
type: Species
is: CHEBI:32984
boundary condition: false
name: N4-{N-Acetyl-beta-D-glucosaminyl-(1,2)-alpha-D-mannosyl-(1,3)-[N-acetyl-beta-D-glucosaminyl-(1,2)-alpha-D-mannosyl-(1,6)]-beta-D-mannosyl-(1,4)-N-acetyl-beta-D-glucosaminyl-(1,4)-[alpha-L-fucosyl-(1,6)]-N-acetyl-beta-D-glucosaminyl}asparagine

http://identifiers.org/biomodels.db/MODEL1310110042#_9ab9b242_41ed_4145_acee_12fd4af82c6f
type: Species
initial amount: NaN
has only substance units: false
is: P09848
is: SBO:0000252
is encoded by: hsa:3938
initial concentration: NaN
name: LCT
boundary condition: true
constant: false

metaR NMNtn
fast: false
type: Reaction
product: MODEL1310110042#
is described by: ECO:0000000
reactant: MODEL1310110042#
is: SBO:0000185
kinetic law: MODEL1310110042#
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: NOTES:it
name: NMN transport, nuclear trhough pore

http://identifiers.org/biomodels.db/MODEL1310110042#_7e6981ff_58e8_4419_a72d_42e7d92b8e89
has part: P31350
type: Species
has only substance units: false
constant: false
is encoded by: hsa:6241
boundary condition: true
is encoded by: hsa:6240
has part: P23921
is: SBO:0000297
initial amount: NaN
name: RRM1:RRM2
initial concentration: NaN

metaR ADPCOACROT
kinetic law: MODEL1310110042#
product: MODEL1310110042#
reactant: MODEL1310110042#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: production of adipoyl carnitine
type: Reaction

metaR OCTDECCACT
kinetic law: MODEL1310110042#
product: MODEL1310110042#
reactant: MODEL1310110042#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: transport of Octadecenoyl-CoA into mitochondrial matrix
type: Reaction

metaR EX 4nphsf LPAREN e RPAREN
kinetic law: MODEL1310110042#
reactant: MODEL1310110042#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 4-Nitrophenyl sulfate exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110042#_dcddaf95_1dc9_4981_94c7_5743c2ab623a
constant: false
boundary condition: true
type: Species
has part: P31153
has only substance units: false
is encoded by: hsa:4144
is: SBO:0000297
initial amount: NaN
is encoded by: hsa:27430
initial concentration: NaN
name: MAT2B:MAT2A

metaR C226CPT2
fast: false
is described by: ECO:0000000
name: C226 transport into the mitochondria
is: SBO:0000176
kinetic law: MODEL1310110042#
reactant: MODEL1310110042#
is version of: http://identifiers.org/ec-code/2.3.1.21
type: Reaction
product: MODEL1310110042#
reversible: false
modifier: MODEL1310110042#
notes: GENE_ASSOCIATION: (1376.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: PMID:11274214,PMID:1528846,PMID:1988962 NOTES:TDV

metaM etfox m
boundary condition: false
is: HMDB00573
notes: FORMULA: R CHARGE: 0
constant: false
name: Electron transfer flavoprotein oxidized
initial concentration: 1.0
initial amount: NaN
type: Species
is: CHEBI:30825
has only substance units: false
is: SBO:0000247

metaM pyam5p c
is: SBO:0000247
initial concentration: 1.0
initial amount: NaN
constant: false
has only substance units: false
type: Species
name: Pyridoxamine 5'-phosphate
is: C00647
boundary condition: false
notes: FORMULA: C8H12N2O5P CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00475 EHMN_ABBREVIATION: C00647
is: HMDB01555
is: CHEBI:58451

metaR r1090
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:10049700,PMID:10574970,PMID:11389679,PMID:11557028,PMID:11564694,PMID:12824232,PMID:12930836,PMID:14574404,PMID:16288981,PMID:911815 NOTES:
name: TCDB:2.A.47.1.9 TCDB:2.A.29.7.2
is described by: ECO:0000000
reactant: MODEL1310110042#
fast: false
reversible: false
is: SBO:0000185
kinetic law: MODEL1310110042#
product: MODEL1310110042#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110042#_53b906af_7fdf_497e_9718_8bfd3cf71a0d
boundary condition: true
is: SBO:0000252
type: Species
initial amount: NaN
is: P22102
initial concentration: NaN
is encoded by: hsa:2618
has only substance units: false
name: GART
constant: false

metaM gdpmann c
type: Species
notes: FORMULA: C16H23N5O16P2 CHARGE: -2 INCHI: InChI=1S/C16H25N5O16P2/c17-16-19-12-6(13(28)20-16)18-3-21(12)14-10(26)8(24)5(34-14)2-33-38(29,30)37-39(31,32)36-15-11(27)9(25)7(23)4(1-22)35-15/h3-5,7-11,14-15,22-27H,1-2H2,(H,29,30)(H,31,32)(H3,17,19,20,28)/p-2/t4-,5-,7-,8-,9+,10-,11+,14-,15-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00098 EHMN_ABBREVIATION: C00096
initial concentration: 1.0
constant: false
is: CHEBI:57527
boundary condition: false
name: GDP-alpha-D-mannose(2-)
is: SBO:0000247
initial amount: NaN
is: HMDB01163
has only substance units: false

metaR DOLPMT2 Uer
name: dolichyl-phosphate-mannose-glycolipid alpha-mannosyltransferase (uterus)
reactant: MODEL1310110042#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: N-glycan synthesis EC Number: 2.4.1.130 Confidence Level: 0 AUTHORS: NOTES:
product: MODEL1310110042#
is: SBO:0000176
is described by: ECO:0000000
fast: false
reversible: false
kinetic law: MODEL1310110042#

metaR LCADi D
is version of: http://identifiers.org/ec-code/1.2.1.3
fast: false
modifier: MODEL1310110042#
reversible: false
is version of: http://identifiers.org/ec-code/1.2.1.36
product: MODEL1310110042#
notes: GENE_ASSOCIATION: (218.1) or (223.1) or (8854.2) or (224.1) or (222.1) or (8854.1) or (221.1) or (216.1) or (8854.3) or (501.1) or (220.1) SUBSYSTEM: Pyruvate metabolism EC Number: 1.2.1.21 Confidence Level: 2 AUTHORS: PMID:15987839,PMID:2296157,PMID:6487654 NOTES:JLR- added irreversible form of LCAD
is version of: http://identifiers.org/ec-code/1.2.1.5
is described by: ECO:0000304
reactant: MODEL1310110042#
type: Reaction
is: SBO:0000176
kinetic law: MODEL1310110042#
name: lactaldehyde dehydrogenase

metaR EX strdnc LPAREN e RPAREN
kinetic law: MODEL1310110042#
reactant: MODEL1310110042#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: stearidonic acid exchange
type: Reaction

metaM 3octdece1coa m
initial amount: NaN
has only substance units: false
name: 3-hydroxyoctadecenoylcoa
constant: false
type: Species
notes: FORMULA: C39H64N7O18P3S CHARGE: -4
initial concentration: 1.0
boundary condition: false
is: http://identifiers.org/pubchem.compound/5280355
is: SBO:0000247

metaR DRPA
reactant: MODEL1310110042#
type: Reaction
is described by: ECO:0000000
reversible: false
product: MODEL1310110042#
kinetic law: MODEL1310110042#
is: SBO:0000176
name: deoxyribose-phosphate aldolase
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Pentose phosphate pathway EC Number: 4.1.2.4 Confidence Level: 2 AUTHORS: NOTES:

metaM prgnlones c
name: pregnenolone sulfate
is: SBO:0000247
boundary condition: false
is: HMDB00774
initial amount: NaN
type: Species
is: CHEBI:35420
notes: FORMULA: C21H31O5S CHARGE: -1 INCHI: InChI=1S/C21H32O5S/c1-13(22)17-6-7-18-16-5-4-14-12-15(26-27(23,24)25)8-10-20(14,2)19(16)9-11-21(17,18)3/h4,15-19H,5-12H2,1-3H3,(H,23,24,25)/t15-,16-,17+,18-,19-,20-,21+/m0/s1 EHMN_ABBREVIATION: CE4764
constant: false
has only substance units: false
initial concentration: 1.0

metaM 3bcrn c
has only substance units: false
is: C14143
initial amount: NaN
boundary condition: false
notes: FORMULA: C11H21NO5 CHARGE: 0
is: HMDB04047
constant: false
initial concentration: 1.0
type: Species
is: SBO:0000247
name: 3-hydroxy butyryl carnitine

http://identifiers.org/biomodels.db/MODEL1310110042#_a8ef1c3c_27d3_428e_bcdb_750fce7ee708
boundary condition: true
initial concentration: NaN
is: P00918
is: SBO:0000252
has only substance units: false
is encoded by: hsa:760
type: Species
constant: false
name: CA2
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110042#_78a8d949_6985_4140_861c_ad3a28559c34
is encoded by: hsa:10195
initial concentration: NaN
boundary condition: true
type: Species
is: SBO:0000252
constant: false
has only substance units: false
initial amount: NaN
name: ALG3

http://identifiers.org/biomodels.db/MODEL1310110042#_430b38b4_6bb5_4671_baa3_8f0d155143cf
name: _100128062_1_m
constant: false
initial amount: NaN
initial concentration: NaN
type: Species
is: SBO:0000252
has only substance units: false
is encoded by: hsa:100128062
boundary condition: true

metaM CE5132 c
has only substance units: false
initial amount: NaN
boundary condition: false
notes: FORMULA: C11H14O19P3R2 CHARGE: -5 EHMN_ABBREVIATION: CE5132
initial concentration: 1.0
constant: false
type: Species
name: 1-phosphatidyl-1D-myo-inositol 3,5-bisphosphate(5-)
is: CHEBI:57923
is: SBO:0000247

metaM mthgxl c
initial amount: NaN
initial concentration: 1.0
is: CHEBI:17158
boundary condition: false
is: SBO:0000247
type: Species
name: methylglyoxal
constant: false
has only substance units: false
notes: FORMULA: C3H4O2 CHARGE: 0 INCHI: InChI=1S/C3H4O2/c1-3(5)2-4/h2H,1H3 HEPATONET_1.0_ABBREVIATION: HC00425 EHMN_ABBREVIATION: C00546
is: HMDB01167

metaR r2367
kinetic law: MODEL1310110042#
product: MODEL1310110042#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
fast: false
reversible: true
name: Organic anion transporter 5 Utilized transport
type: Reaction
is: SBO:0000185
reactant: MODEL1310110042#
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110042#_d299d8f4_951f_4f6b_b5b1_e260bd0defd6
boundary condition: true
name: B3GALT5
has only substance units: false
initial concentration: NaN
constant: false
type: Species
is encoded by: hsa:10317
is: SBO:0000252
initial amount: NaN

metaR r2141
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.14
type: Reaction
fast: false
is: SBO:0000185
product: MODEL1310110042#
reactant: MODEL1310110042#
reversible: true
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
kinetic law: MODEL1310110042#
modifier: MODEL1310110042#
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110042#_14105641_d024_426d_b4ec_e2f9f0356669
initial amount: NaN
initial concentration: NaN
boundary condition: true
has only substance units: false
name: ADSSL1
is: SBO:0000252
is encoded by: hsa:122622
is: Q8N142
type: Species
constant: false

http://identifiers.org/biomodels.db/MODEL1310110042#_f5953685_d1be_4f8b_b2b8_211121b362f1
name: ALDH2
boundary condition: true
type: Species
is: SBO:0000252
is encoded by: hsa:217
is: P05091
initial amount: NaN
constant: false
initial concentration: NaN
has only substance units: false

metaM ei11ecoa x
constant: false
initial amount: NaN
is: http://identifiers.org/pubchem.compound/24892790
type: Species
boundary condition: false
initial concentration: 1.0
notes: FORMULA: C41H68N7O17P3S CHARGE: -4
name: 11-eicosenoylcoa
is: SBO:0000247
has only substance units: false

metaM tmndnccoa c
name: timnodonyl coenzyme A
notes: FORMULA: C41H60N7O17P3S CHARGE: -4 INCHI: InChI=1/C41H64N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-32(50)69-25-24-43-31(49)22-23-44-39(53)36(52)41(2,3)27-62-68(59,60)65-67(57,58)61-26-30-35(64-66(54,55)56)34(51)40(63-30)48-29-47-33-37(42)45-28-46-38(33)48/h5-6,8-9,11-12,14-15,17-18,28-30,34-36,40,51-52H,4,7,10,13,16,19-27H2,1-3H3,(H,43,49)(H,44,53)(H,57,58)(H,59,60)(H2,42,45,46)(H2,54,55,56)/b6-5-,9-8-,12-11-,15-14-,18-17-/t30-,34-,35?,36+,40-/m1/s1
is: SBO:0000247
has only substance units: false
boundary condition: false
is: HMDB06514
constant: false
initial amount: NaN
initial concentration: 1.0
type: Species

metaR FAOXC204C205x
kinetic law: MODEL1310110042#
product: MODEL1310110042#
reactant: MODEL1310110042#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C20:4-->C20:5)x
type: Reaction

metaM ptth m
is: SBO:0000247
type: Species
has only substance units: false
is: CHEBI:16753
name: pantetheine
is: HMDB03426
notes: FORMULA: C11H22N2O4S CHARGE: 0 INCHI: InChI=1S/C11H22N2O4S/c1-11(2,7-14)9(16)10(17)13-4-3-8(15)12-5-6-18/h9,14,16,18H,3-7H2,1-2H3,(H,12,15)(H,13,17)/t9-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00554 EHMN_ABBREVIATION: C00831
initial concentration: 1.0
boundary condition: false
constant: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110042#_7c2ac0c0_4a33_4fc7_ab50_b52cadd90937
has only substance units: false
is: SBO:0000252
is encoded by: hsa:AI469183
initial concentration: NaN
type: Species
boundary condition: true
name: _AI469183_1_x
constant: false
initial amount: NaN

metaM 3aib D m
initial concentration: 1.0
has only substance units: false
is: C03265
is: SBO:0000247
type: Species
is: HMDB02299
constant: false
name: D-3-Amino-isobutanoate
initial amount: NaN
boundary condition: false
notes: FORMULA: C4H9NO2 CHARGE: 0 INCHI: InChI=1/C4H9NO2/c1-3(2-5)4(6)7/h3H,2,5H2,1H3,(H,6,7)/t3-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00715

metaM pan4p c
is: SBO:0000247
initial concentration: 1.0
notes: FORMULA: C11H21N2O7PS CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00681 EHMN_ABBREVIATION: C01134
initial amount: NaN
is: C01134
is: CHEBI:47942
has only substance units: false
type: Species
is: HMDB01416
boundary condition: false
name: Pantetheine 4'-phosphate
constant: false

http://identifiers.org/biomodels.db/MODEL1310110042#_530be0e5_205b_4dc4_9616_e9fb1ea67796
is: SBO:0000252
type: Species
initial amount: NaN
initial concentration: NaN
is: P14618
constant: false
boundary condition: true
has only substance units: false
is encoded by: hsa:5315
name: PKM2

metaR AKGtp
type: Reaction
reversible: true
kinetic law: MODEL1310110042#
product: MODEL1310110042#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 0 AUTHORS: NOTES:unknown mechanism NJ
is described by: ECO:0000000
reactant: MODEL1310110042#
name: AKG transporter, peroxisome
fast: false

metaM nadph m
boundary condition: false
type: Species
constant: false
is: C00005
name: Nicotinamide adenine dinucleotide phosphate - reduced
is: SBO:0000247
is: CHEBI:57783
initial concentration: 1.0
is: HMDB00221
notes: FORMULA: C21H26N7O17P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00015 EHMN_ABBREVIATION: C00005
has only substance units: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110042#_3079ef29_bab9_4600_984f_eafed980c92f
has only substance units: false
type: Species
is: O95992
boundary condition: true
is: SBO:0000252
is encoded by: hsa:9023
name: CH25H
initial concentration: NaN
initial amount: NaN
constant: false

metaM ksi pre27 g
initial concentration: 1.0
initial amount: NaN
is: C00130
has only substance units: false
boundary condition: false
is: CHEBI:58053
type: Species
notes: FORMULA: C205H328N14O171S8X CHARGE: -9
is: HMDB00175
constant: false
is: SBO:0000247
name: keratan sulfate I biosynthesis, precursor 27

http://identifiers.org/biomodels.db/MODEL1310110042#_5fc0babd_7c42_4e0d_bbf6_1fdbd6ee7c73
constant: false
boundary condition: true
name: EGFR
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:1956
has only substance units: false
is: SBO:0000252
is: P00533
type: Species

metaR r2366
fast: false
name: Organic anion transporter 5 Utilized transport
is described by: ECO:0000000
is: SBO:0000185
reactant: MODEL1310110042#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
reversible: true
kinetic law: MODEL1310110042#
product: MODEL1310110042#
type: Reaction

metaR r2140
is described by: ECO:0000000
is: SBO:0000185
product: MODEL1310110042#
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.14
reactant: MODEL1310110042#
kinetic law: MODEL1310110042#
type: Reaction
fast: false
reversible: true
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
modifier: MODEL1310110042#

metaM cspg a l
constant: false
has only substance units: false
initial concentration: 1.0
initial amount: NaN
boundary condition: false
notes: FORMULA: C45H66N2O45S3X CHARGE: -5
type: Species
name: chondroitin sulfate A (GalNAc4S-GlcA) proteoglycan
is: CHEBI:36005
is: HMDB02183
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110042#_75ce681b_440c_4c34_8f6c_798b4d8ee4e0
is: SBO:0000252
is encoded by: hsa:10861
constant: false
initial amount: NaN
initial concentration: NaN
type: Species
name: SLC26A1
has only substance units: false
boundary condition: true

metaR DOLPMT L
fast: false
type: Reaction
is described by: ECO:0000000
modifier: MODEL1310110042#
kinetic law: MODEL1310110042#
notes: GENE_ASSOCIATION: (54344.2 and 8818.1 and 8813.1) or (8818.2 and 54344.1 and 8813.1) or (8818.1 and 54344.1 and 8813.1) or (54344.2 and 8818.2 and 8813.1) SUBSYSTEM: N-glycan synthesis EC Number: 2.4.1.83 Confidence Level: 0 AUTHORS: PMID:11420690 NOTES:NCD
product: MODEL1310110042#
is version of: http://identifiers.org/ec-code/2.4.1.83
is: SBO:0000176
reversible: false
reactant: MODEL1310110042#
name: Dolichyl-phosphate D-mannosyltransferase (liver)

metaM amet c
boundary condition: false
initial concentration: 1.0
has only substance units: false
is: C00019
type: Species
is: CHEBI:15414
constant: false
initial amount: NaN
is: SBO:0000247
is: HMDB01185
name: S-Adenosyl-L-methionine
notes: FORMULA: C15H23N6O5S CHARGE: 1 HEPATONET_1.0_ABBREVIATION: HC00029 EHMN_ABBREVIATION: C00019

metaR RE2814M
type: Reaction
name: RE2814
reversible: true
kinetic law: MODEL1310110042#
is described by: ECO:0000000
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Bile acid synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:0 NOTES:
fast: false
product: MODEL1310110042#
reactant: MODEL1310110042#

http://identifiers.org/biomodels.db/MODEL1310110042#_55af8f47_79e3_485f_bc6a_9e11836e2ab0
boundary condition: true
name: SUCLA2
has only substance units: false
initial amount: NaN
is: SBO:0000252
is encoded by: hsa:8803
is: E5KS60
initial concentration: NaN
constant: false
type: Species

metaR DTDPtn
is: SBO:0000185
reactant: MODEL1310110042#
type: Reaction
is described by: ECO:0000000
kinetic law: MODEL1310110042#
fast: false
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: NOTES:NCD
product: MODEL1310110042#
name: dTDP nuclear transport

metaM T4hcinnm m
constant: false
is: SBO:0000247
is: CHEBI:12876
has only substance units: false
name: trans-4-coumarate
boundary condition: false
is: HMDB02035
initial concentration: 1.0
type: Species
initial amount: NaN
notes: FORMULA: C9H7O3 CHARGE: -1 INCHI: InChI=1S/C9H8O3/c10-8-4-1-7(2-5-8)3-6-9(11)12/h1-6,10H,(H,11,12)/p-1/b6-3+ EHMN_ABBREVIATION: C00811

metaR EX xyl D LPAREN e RPAREN
kinetic law: MODEL1310110042#
reactant: MODEL1310110042#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: D-Xylose exchange
type: Reaction

metaM lnlncg e
is: CHEBI:32391
has only substance units: false
notes: FORMULA: C18H29O2 CHARGE: -1 INCHI: InChI=1S/C18H30O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20/h6-7,9-10,12-13H,2-5,8,11,14-17H2,1H3,(H,19,20)/p-1/b7-6-,10-9-,13-12-
is: HMDB03073
type: Species
initial amount: NaN
constant: false
name: gamma-linolenate
initial concentration: 1.0
is: SBO:0000247
boundary condition: false

metaM pmtcoa r
boundary condition: false
constant: false
is: SBO:0000247
is: CHEBI:3454
is: HMDB01338
notes: FORMULA: C37H62N7O17P3S CHARGE: -4
initial concentration: 1.0
has only substance units: false
name: Palmitoyl-CoA (n-C16:0CoA)
initial amount: NaN
is: C00154
type: Species

metaR S6TASE17ly
type: Reaction
kinetic law: MODEL1310110042#
reactant: MODEL1310110042#
reversible: true
is version of: http://identifiers.org/ec-code/3.1.6.14
product: MODEL1310110042#
modifier: MODEL1310110042#
notes: GENE_ASSOCIATION: (2799.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.1.6.14 Confidence Level: 4 AUTHORS: PMID:3196333,PMID:3689314,PMID:3689315 NOTES:NCD
fast: false
is: SBO:0000176
is described by: ECO:0000000
name: N-acetylglucosamine-6-sulfatase, lysosomal

metaR r2369
kinetic law: MODEL1310110042#
product: MODEL1310110042#
fast: false
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
type: Reaction
is: SBO:0000185
name: Organic anion transporter 5 Utilized transport
reactant: MODEL1310110042#
is described by: ECO:0000000

metaM ksi pre1 g
name: keratan sulfate I biosynthesis, precursor 1
boundary condition: false
is: CHEBI:58053
is: C00130
type: Species
constant: false
initial concentration: 1.0
initial amount: NaN
is: HMDB00175
is: SBO:0000247
has only substance units: false
notes: FORMULA: C79H129N5O57X CHARGE: -1

http://identifiers.org/biomodels.db/MODEL1310110042#_3019a47e_42e0_4ff3_8a5f_5ed4b90b58d4
initial concentration: NaN
initial amount: NaN
has only substance units: false
boundary condition: true
constant: false
name: SLC7A5
is encoded by: hsa:8140
is: Q8IV97
is: SBO:0000252
type: Species

metaR URCN
is version of: http://identifiers.org/ec-code/4.2.1.49
notes: GENE_ASSOCIATION: (131669.1) SUBSYSTEM: Histidine metabolism EC Number: Confidence Level: 4 AUTHORS: NOTES:
is described by: ECO:0000269
is: SBO:0000176
name: URCN
type: Reaction
modifier: MODEL1310110042#
fast: false
kinetic law: MODEL1310110042#
reactant: MODEL1310110042#
product: MODEL1310110042#
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110042#_bd69796c_4124_4a55_a58b_33d936b3116f
initial amount: NaN
name: GART
is: Q59HH3
initial concentration: NaN
constant: false
boundary condition: true
is: SBO:0000252
has only substance units: false
type: Species
is encoded by: hsa:2618

metaM ha l
initial concentration: 1.0
initial amount: NaN
has only substance units: false
name: hyaluronan
is: CHEBI:16336
notes: FORMULA: C28H40N2O22 CHARGE: -2 EHMN_ABBREVIATION: C00518
boundary condition: false
constant: false
type: Species
is: SBO:0000247

metaR GTHRDt
reactant: MODEL1310110042#
name: Glutathione transport into mitochondria
is described by: ECO:0000000
is: SBO:0000185
fast: false
product: MODEL1310110042#
kinetic law: MODEL1310110042#
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Glutathione metabolism EC Number: Confidence Level: 2 AUTHORS: NOTES:TV (8-15-2003) Meister, A, Mitochondrial changes associated with glutathione deficiency, Biochimica et Biophysica Acta 1271 (1995) 35-42. The article reports that this is an active transport but doesn't not specify if it uses atp.
type: Reaction

metaR EX tettet6 LPAREN e RPAREN
kinetic law: MODEL1310110042#
reactant: MODEL1310110042#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: tetracosatetraenoic acid n-6 exchange
type: Reaction

metaR ELAIDCRNt
notes: GENE_ASSOCIATION: (788.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: NOTES:NJ
fast: false
reversible: false
product: MODEL1310110042#
kinetic law: MODEL1310110042#
type: Reaction
is: SBO:0000185
reactant: MODEL1310110042#
modifier: MODEL1310110042#
name: transport into the mitochondria (carnitine)
is described by: ECO:0000000

metaR C51CPT1
kinetic law: MODEL1310110042#
product: MODEL1310110042#
reactant: MODEL1310110042#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: production of tiglylcarnitine
type: Reaction

metaR FACOAL140i
is version of: http://identifiers.org/ec-code/6.2.1.3
modifier: MODEL1310110042#
reactant: MODEL1310110042#
is described by: ECO:0000269
reversible: false
product: MODEL1310110042#
is: SBO:0000176
name: fatty-acid--CoA ligase (tetradecanoate)
kinetic law: MODEL1310110042#
fast: false
notes: GENE_ASSOCIATION: (2181.1) SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 4 AUTHORS: NOTES:JLR
type: Reaction

metaR C12DCTD
kinetic law: MODEL1310110042#
product: MODEL1310110042#
reactant: MODEL1310110042#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: transport of Dodecanedioic acid by diffusion
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110042#_1a4dcc75_7d2c_4120_8dac_e93713762b73
boundary condition: true
type: Species
initial amount: NaN
name: PANK2
is encoded by: hsa:80025
initial concentration: NaN
is: Q6P1K9
has only substance units: false
is: SBO:0000252
constant: false

metaM pan4p e
name: Pantetheine 4'-phosphate
initial concentration: 1.0
initial amount: NaN
is: C01134
is: CHEBI:47942
type: Species
notes: FORMULA: C11H21N2O7PS CHARGE: -2
is: HMDB01416
constant: false
has only substance units: false
is: SBO:0000247
boundary condition: false

metaM glac r
notes: FORMULA: C6H8O6 CHARGE: 0 INCHI: InChI=1S/C6H8O6/c7-1-2(8)5-3(9)4(10)6(11)12-5/h1-5,8-10H/t2-,3+,4-,5+/m0/s1
constant: false
name: D-glucurono-6,3-lactone
boundary condition: false
is: HMDB06355
has only substance units: false
initial amount: NaN
initial concentration: 1.0
is: CHEBI:18268
type: Species
is: SBO:0000247

metaR r2368
is: SBO:0000185
name: Organic anion transporter 5 Utilized transport
reactant: MODEL1310110042#
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
type: Reaction
kinetic law: MODEL1310110042#
is described by: ECO:0000000
product: MODEL1310110042#
fast: false

metaR TCYNTtm
is: SBO:0000185
reversible: false
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: PMID:6351723 NOTES:thiocyanate is found excreted in urine (PMID: 6351723) MM
type: Reaction
name: Thiocyanate transport via diffusion (mitochondrial)
fast: false
product: MODEL1310110042#
kinetic law: MODEL1310110042#
reactant: MODEL1310110042#

metaR LINKDEG1ly
is described by: ECO:0000000
is: SBO:0000176
type: Reaction
name: degradation of proteoglycan linkage region, lysosomal
reactant: MODEL1310110042#
kinetic law: MODEL1310110042#
reversible: false
product: MODEL1310110042#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Heparan sulfate degradation EC Number: Confidence Level: 2 AUTHORS: PMID:8993162 NOTES:NCD

metaM m8masn r
notes: FORMULA: C70H117N2O55X CHARGE: 0
has only substance units: false
constant: false
is: C05876
initial concentration: 1.0
is: SBO:0000247
type: Species
name: (alpha-D-mannosyl)8-beta-D-mannosyl-diacetylchitobiosyl-L-asparagine (protein)
initial amount: NaN
boundary condition: false

metaR r2142
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.14
kinetic law: MODEL1310110042#
modifier: MODEL1310110042#
fast: false
type: Reaction
product: MODEL1310110042#
reversible: true
reactant: MODEL1310110042#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110042#_1e57976d_8786_4a82_babe_e086b9d95eb9
type: Species
initial amount: NaN
is: O75355
is encoded by: hsa:956
constant: false
is: SBO:0000252
boundary condition: true
initial concentration: NaN
has only substance units: false
name: ENTPD3

metaM od2coa m
name: trans-Octadec-2-enoyl-CoA
initial amount: NaN
is: CHEBI:50570
constant: false
boundary condition: false
has only substance units: false
type: Species
initial concentration: 1.0
notes: FORMULA: C39H64N7O17P3S CHARGE: -4 INCHI: InChI=1S/C39H68N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-30(48)67-23-22-41-29(47)20-21-42-37(51)34(50)39(2,3)25-60-66(57,58)63-65(55,56)59-24-28-33(62-64(52,53)54)32(49)38(61-28)46-27-45-31-35(40)43-26-44-36(31)46/h18-19,26-28,32-34,38,49-50H,4-17,20-25H2,1-3H3,(H,41,47)(H,42,51)(H,55,56)(H,57,58)(H2,40,43,44)(H2,52,53,54)/b19-18+/t28-,32-,33-,34+,38-/m1/s1 EHMN_ABBREVIATION: CE2244
is: HMDB06529
is: SBO:0000247

metaR NDP8ex
is: SBO:0000176
kinetic law: MODEL1310110042#
modifier: MODEL1310110042#
reversible: false
product: MODEL1310110042#
is described by: ECO:0000269
name: nucleoside-diphosphatase (UTP), extracellular
fast: false
reactant: MODEL1310110042#
notes: GENE_ASSOCIATION: (124583.1) SUBSYSTEM: Nucleotide interconversion EC Number: 3.6.1.6 Confidence Level: 4 AUTHORS: PMID:12234496,PMID:12600208 NOTES:
type: Reaction
is version of: http://identifiers.org/ec-code/3.6.1.6

metaR FAOXC181C181OHm
kinetic law: MODEL1310110042#
product: MODEL1310110042#
reactant: MODEL1310110042#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C18:1-->C18:1OH)m
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110042#_47d6f638_7d83_48f2_af51_00c6fb826282
boundary condition: true
constant: false
is: SBO:0000252
initial concentration: NaN
has only substance units: false
name: SLC2A2
type: Species
is: P11168
initial amount: NaN
is encoded by: hsa:6514

http://identifiers.org/biomodels.db/MODEL1310110042#_2cb8081d_4a36_4e76_9b21_31911535c37a
is: O75251
is: SBO:0000252
initial amount: NaN
name: NDUFS7
type: Species
boundary condition: true
initial concentration: NaN
is encoded by: hsa:374291
constant: false
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110042#_620643c1_6026_4479_9e6c_a70f15a8475d
is: Q59EH3
is: SBO:0000252
type: Species
initial amount: NaN
initial concentration: NaN
constant: false
has only substance units: false
is encoded by: hsa:52
name: ACP1
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110042#_a04c4e5b_f805_4cfe_b56d_28ce8cc74c98
initial amount: NaN
boundary condition: true
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:2679
constant: false
name: GGT3P
type: Species
has only substance units: false

metaR CHOLtn
fast: false
name: Choline transport, nuclear through pores
reactant: MODEL1310110042#
is: SBO:0000185
kinetic law: MODEL1310110042#
is described by: ECO:0000000
product: MODEL1310110042#
type: Reaction
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: NOTES:it

metaR RE2814R
is described by: ECO:0000000
is: SBO:0000176
name: RE2814
reversible: true
reactant: MODEL1310110042#
fast: false
type: Reaction
product: MODEL1310110042#
kinetic law: MODEL1310110042#
notes: GENE_ASSOCIATION: SUBSYSTEM: Bile acid synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:0 NOTES:

metaR GLCAASE4ly
reversible: false
name: beta-glucuronidase, lysosomal
notes: GENE_ASSOCIATION: (2990.1) SUBSYSTEM: Chondroitin sulfate degradation EC Number: 3.2.1.31 Confidence Level: 4 AUTHORS: PMID:3468507,PMID:3924735,PMID:3987656 NOTES:NCD
product: MODEL1310110042#
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/3.2.1.31
type: Reaction
modifier: MODEL1310110042#
is: SBO:0000176
kinetic law: MODEL1310110042#
fast: false
reactant: MODEL1310110042#

metaM HC01104 e
type: Species
boundary condition: false
is: CHEBI:61146
has only substance units: false
constant: false
name: 4-nitrophenyl phosphate(2-)
notes: FORMULA: C6H4NO6P CHARGE: -2 INCHI: InChI=1S/C6H6NO6P/c8-7(9)5-1-3-6(4-2-5)13-14(10,11)12/h1-4H,(H2,10,11,12)/p-2 EHMN_ABBREVIATION: C03360
is: SBO:0000247
initial amount: NaN
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110042#_d367dee7_5a83_49ee_8e77_58bb78b566db
is: SBO:0000252
is encoded by: hsa:6528
has only substance units: false
is: Q92911
initial concentration: NaN
constant: false
name: SLC5A5
boundary condition: true
initial amount: NaN
type: Species

metaR EX tcynt LPAREN e RPAREN
kinetic law: MODEL1310110042#
reactant: MODEL1310110042#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Thiocyanate exchange
type: Reaction

metaM hpdcacrn c
initial concentration: 1.0
notes: FORMULA: C24H47NO4 CHARGE: 0 INCHI: InChI=1/C24H47NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-24(28)29-22(20-23(26)27)21-25(2,3)4/h22H,5-21H2,1-4H3
is: HMDB06210
constant: false
initial amount: NaN
is: SBO:0000247
boundary condition: false
has only substance units: false
type: Species
name: heptadecanoyl carnitine

metaM 3octdece1coa c
initial concentration: 1.0
has only substance units: false
notes: FORMULA: C39H64N7O18P3S CHARGE: -4
initial amount: NaN
is: HMDB13336
is: SBO:0000247
name: 3-hydroxyoctadecenoylcoa
constant: false
type: Species
boundary condition: false

metaM hs deg24 l
is: CHEBI:16126
type: Species
has only substance units: false
name: GlcNAc-GlcA-(Gal)2-Xyl
boundary condition: false
initial concentration: 1.0
initial amount: NaN
notes: FORMULA: C31H50NO26 CHARGE: -1
constant: false
is: SBO:0000247

metaM HC02204 e
boundary condition: false
is: SBO:0000247
type: Species
is: CHEBI:27624
constant: false
has only substance units: false
name: prostaglandin-b1
initial concentration: 1.0
notes: FORMULA: C20H31O4 CHARGE: -1 INCHI: InChI=1S/C20H32O4/c1-2-3-6-9-17(21)14-12-16-13-15-19(22)18(16)10-7-4-5-8-11-20(23)24/h12,14,17,21H,2-11,13,15H2,1H3,(H,23,24)/b14-12+/t17-/m0/s1 EHMN_ABBREVIATION: C00959
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110042#_7ae8b8ed_debc_4cad_a12b_113daeb10e50
name: B3GNT7
type: Species
is: Q8NFL0
has only substance units: false
is encoded by: hsa:93010
constant: false
initial amount: NaN
boundary condition: true
initial concentration: NaN
is: SBO:0000252

metaR MI145PK
is described by: ECO:0000269
fast: false
is: SBO:0000176
product: MODEL1310110042#
modifier: MODEL1310110042#
notes: GENE_ASSOCIATION: (3706.1) or (80271.1) or (3707.1) SUBSYSTEM: Inositol phosphate metabolism EC Number: 2.7.1.127 Confidence Level: 4 AUTHORS: PMID:11085927,PMID:1654894,PMID:2906139 NOTES:NCD
reversible: false
name: inositol-1,4,5-trisphosphate 3-kinase
type: Reaction
is version of: http://identifiers.org/ec-code/2.7.1.127
reactant: MODEL1310110042#
kinetic law: MODEL1310110042#

metaR ACACT1rm
is version of: http://identifiers.org/ec-code/2.3.1.9
fast: false
is version of: http://identifiers.org/ec-code/2.3.1.16
reversible: true
type: Reaction
product: MODEL1310110042#
kinetic law: MODEL1310110042#
modifier: MODEL1310110042#
is: SBO:0000176
reactant: MODEL1310110042#
name: acetyl-CoA C-acetyltransferase, mitochondrial
notes: GENE_ASSOCIATION: (3030.1) and (3032.1) or (38.1) SUBSYSTEM: Tryptophan metabolism EC Number: 2.3.1.9 Confidence Level: 0 AUTHORS: NOTES:TDV
is version of: http://identifiers.org/ec-code/4.2.1.17
is described by: ECO:0000000

metaM pmtcoa m
type: Species
is: SBO:0000247
is: CHEBI:57379
has only substance units: false
constant: false
initial concentration: 1.0
is: C00154
is: HMDB01338
initial amount: NaN
notes: FORMULA: C37H62N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00150 EHMN_ABBREVIATION: C00154
name: Palmitoyl-CoA (n-C16:0CoA)
boundary condition: false

metaR FAOXC184x
kinetic law: MODEL1310110042#
product: MODEL1310110042#
reactant: MODEL1310110042#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: isomerization(C18:4)x
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110042#_5133ae6f_4848_4316_a3d8_742b45801f7e
initial concentration: NaN
is encoded by: hsa:291
is: P12235
boundary condition: true
has only substance units: false
is: SBO:0000252
name: SLC25A4
type: Species
initial amount: NaN
constant: false

metaM frdp c
boundary condition: false
has only substance units: false
notes: FORMULA: C15H25O7P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00362 EHMN_ABBREVIATION: C00448
is: CHEBI:175763
is: HMDB00961
constant: false
type: Species
initial amount: NaN
name: Farnesyl diphosphate
initial concentration: 1.0
is: SBO:0000247
is: C00448

metaR r0311
modifier: MODEL1310110042#
reactant: MODEL1310110042#
fast: false
notes: GENE_ASSOCIATION: (30.1) or (10449.1) or (38.1) or (39.1) or (3032.1) or (4645.1) SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 0 AUTHORS: PMID:8584017 NOTES:
product: MODEL1310110042#
is version of: http://identifiers.org/ec-code/2.3.1.9
is version of: http://identifiers.org/ec-code/2.3.1.16
reversible: false
kinetic law: MODEL1310110042#
name: Palmitate:CoA ligase (AMP-forming) Fatty acid metabolism EC:6.2.1.3
is: SBO:0000176
type: Reaction
is described by: ECO:0000000

metaR FADH2tx
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 1 AUTHORS: NOTES:most likely NOT physiological - detailed information about the peroxisomal transporters has not yet been achieved - this transport is most likely dependent on a concomitant energy consuming reaction (human ABC peroxisomal transporters: PEX family - check in future for new research articles describing biochemistry and stoichiometry) NJ
is described by: ECO:0000000
reversible: true
fast: false
product: MODEL1310110042#
reactant: MODEL1310110042#
name: FADH2 transporter, peroxisomal
is: SBO:0000185
kinetic law: MODEL1310110042#

metaR HPACtr
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:3753983 NOTES:SAB
name: hydroxyphenylacetate transport via diffusion
product: MODEL1310110042#
kinetic law: MODEL1310110042#
reactant: MODEL1310110042#
fast: false
type: Reaction
is described by: ECO:0000000
is: SBO:0000185
reversible: true

metaR C4tmc
kinetic law: MODEL1310110042#
product: MODEL1310110042#
reactant: MODEL1310110042#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: transport of bytyrylcarnitine into mitochondrial matrix
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110042#_af305b9a_6ccc_4474_88f8_15f655563fdd
type: Species
constant: false
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:29926
is: SBO:0000252
name: GMPPA
has only substance units: false
is: Q96IJ6
boundary condition: true

metaR GASNASEly
kinetic law: MODEL1310110042#
reactant: MODEL1310110042#
is: SBO:0000176
is described by: ECO:0000000
reversible: false
product: MODEL1310110042#
is version of: http://identifiers.org/ec-code/3.5.1.26
notes: GENE_ASSOCIATION: (175.1) SUBSYSTEM: N-glycan degradation EC Number: 3.5.1.26 Confidence Level: 0 AUTHORS: NOTES:NCD
modifier: MODEL1310110042#
fast: false
name: glycosylasparaginase, lysosomal
type: Reaction

metaM lnlnca e
type: Species
is: HMDB01388
is: SBO:0000247
name: alpha-linolenate
initial amount: NaN
constant: false
initial concentration: 1.0
has only substance units: false
boundary condition: false
is: CHEBI:32387
notes: FORMULA: C18H29O2 CHARGE: -1 INCHI: InChI=1S/C18H30O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20/h3-4,6-7,9-10H,2,5,8,11-17H2,1H3,(H,19,20)/p-1/b4-3-,7-6-,10-9-

http://identifiers.org/biomodels.db/MODEL1310110042#_8e055608_4911_4168_97d1_931f9255fb7f
is: GO:0005615
is: SBO:0000290
constant: false
size: 1.0
spatial dimensions: 3.0
name: extracellular space
type: Compartment

metaM HC00250 c
type: Species
has only substance units: false
notes: FORMULA: HS CHARGE: -1 INCHI: InChI=1S/H2S/h1H2/p-1 EHMN_ABBREVIATION: C00283
is: SBO:0000247
initial amount: NaN
initial concentration: 1.0
name: hydrosulfide
constant: false
is: CHEBI:29919
boundary condition: false

metaR PHEMEtm
type: Reaction
is: SBO:0000185
name: Heme transport to cytosol
reversible: true
kinetic law: MODEL1310110042#
reactant: MODEL1310110042#
product: MODEL1310110042#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: NOTES:TDV changed name to"tm" to indicate mitochondrial transport NCD
fast: false
is described by: ECO:0000000

metaR FAOXC122C101m
kinetic law: MODEL1310110042#
product: MODEL1310110042#
reactant: MODEL1310110042#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C12:2-->C10:1)m
type: Reaction

metaR PAPStg
modifier: MODEL1310110042#
product: MODEL1310110042#
reactant: MODEL1310110042#
kinetic law: MODEL1310110042#
type: Reaction
is: SBO:0000185
reversible: true
name: 3'-Phosphoadenylyl sufate Golgi transport
notes: GENE_ASSOCIATION: (347734.1) SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 4 AUTHORS: PMID:12716889 NOTES:NCD
fast: false
is described by: ECO:0000269

metaR r1993
kinetic law: MODEL1310110042#
type: Reaction
fast: false
reversible: false
modifier: MODEL1310110042#
product: MODEL1310110042#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.15
is: SBO:0000185
reactant: MODEL1310110042#

metaR EX CE2839 LPAREN e RPAREN
kinetic law: MODEL1310110042#
reactant: MODEL1310110042#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: maltodecaose exchange
type: Reaction

metaR URIt5le
modifier: MODEL1310110042#
product: MODEL1310110042#
notes: GENE_ASSOCIATION: (64078.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
reactant: MODEL1310110042#
kinetic law: MODEL1310110042#
is: SBO:0000185
fast: false
is described by: ECO:0000134
name: uridine transport in via sodium symport (1:2)
reversible: false
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110042#_3ec79f4d_a9b3_4d67_8345_8260fbebc80d
constant: false
initial concentration: NaN
has only substance units: false
initial amount: NaN
name: GLS
boundary condition: true
is: O94925
type: Species
is encoded by: hsa:2744
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110042#_605acaa2_57fd_40e2_bbd5_dab54d4d531f
is: SBO:0000252
boundary condition: true
constant: false
type: Species
initial amount: NaN
initial concentration: NaN
name: DGKE
is: A1L4Q0
is encoded by: hsa:8526
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110042#_2563ddb5_fdcb_4714_a83e_8ba2acda124b
name: B4GALT2
constant: false
is: O60909
initial concentration: NaN
has only substance units: false
type: Species
initial amount: NaN
boundary condition: true
is: SBO:0000252
is encoded by: hsa:8704

metaM nadph r
is: HMDB00221
is: CHEBI:57783
name: Nicotinamide adenine dinucleotide phosphate - reduced
is: SBO:0000247
notes: FORMULA: C21H26N7O17P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00015 EHMN_ABBREVIATION: C00005
has only substance units: false
is: C00005
constant: false
initial amount: NaN
type: Species
initial concentration: 1.0
boundary condition: false

metaR r0734
reversible: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.17 Confidence Level: 0 AUTHORS: PMID:8012501,PMID:8188243 NOTES:
is: SBO:0000176
name: (S)-Hydroxyhexanoyl-CoA hydro-lyase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:4.2.1.17
fast: false
reactant: MODEL1310110042#
kinetic law: MODEL1310110042#
is described by: ECO:0000000
type: Reaction
product: MODEL1310110042#

metaM HC02204 c
boundary condition: false
initial amount: NaN
type: Species
is: CHEBI:27624
is: SBO:0000247
has only substance units: false
constant: false
name: prostaglandin-b1
initial concentration: 1.0
notes: FORMULA: C20H31O4 CHARGE: -1 INCHI: InChI=1S/C20H32O4/c1-2-3-6-9-17(21)14-12-16-13-15-19(22)18(16)10-7-4-5-8-11-20(23)24/h12,14,17,21H,2-11,13,15H2,1H3,(H,23,24)/b14-12+/t17-/m0/s1 EHMN_ABBREVIATION: C00959

metaR DPHMBDCm
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Ubiquinone synthesis EC Number: Confidence Level: 2 AUTHORS: PMID:11051212,PMID:7380842 NOTES:enzyme has not been identified yet IT
product: MODEL1310110042#
is described by: ECO:0000000
kinetic law: MODEL1310110042#
reversible: false
type: Reaction
reactant: MODEL1310110042#
name: 3-Decaprenyl-4-hydroxy-5-methoxybenzoate decarboxylation
is: SBO:0000176

metaM HC00250 e
boundary condition: false
name: hydrosulfide
notes: FORMULA: HS CHARGE: -1 INCHI: InChI=1S/H2S/h1H2/p-1 EHMN_ABBREVIATION: C00283
is: SBO:0000247
type: Species
initial amount: NaN
is: CHEBI:29919
has only substance units: false
initial concentration: 1.0
constant: false

metaM 2dp6mep m
boundary condition: false
is: SBO:0000247
initial concentration: 1.0
notes: FORMULA: C57H88O2 CHARGE: 0 INCHI: InChI=1S/C57H88O2/c1-45(2)23-13-24-46(3)25-14-26-47(4)27-15-28-48(5)29-16-30-49(6)31-17-32-50(7)33-18-34-51(8)35-19-36-52(9)37-20-38-53(10)39-21-40-54(11)43-44-55-41-22-42-56(59-12)57(55)58/h22-23,25,27,29,31,33,35,37,39,41-43,58H,13-21,24,26,28,30,32,34,36,38,40,44H2,1-12H3/b46-25+,47-27+,48-29+,49-31+,50-33+,51-35+,52-37+,53-39+,54-43+
constant: false
type: Species
initial amount: NaN
is: CHEBI:50774
name: 2-Decaprenyl-6-methoxyphenol
has only substance units: false

metaM CE5869 e
constant: false
is: HMDB02710
is: SBO:0000247
initial amount: NaN
is: CHEBI:27485
type: Species
boundary condition: false
notes: FORMULA: C11H22N3O3 CHARGE: 1 INCHI: InChI=1/C11H21N3O3/c12-6-2-1-4-8(13)10(15)14-7-3-5-9(14)11(16)17/h8-9H,1-7,12-13H2,(H,16,17)/p+1/t8-,9-/m1/s1 EHMN_ABBREVIATION: CE5869
initial concentration: 1.0
name: lysyl-proline
has only substance units: false

metaM CE4723 e
initial concentration: 1.0
notes: FORMULA: C29H40N5O9 CHARGE: -1 INCHI: InChI=1/C29H41N5O9/c1-16(2)24(26(39)31-20(11-12-23(36)37)28(41)34-14-4-6-22(34)29(42)43)32-25(38)21-5-3-13-33(21)27(40)19(30)15-17-7-9-18(35)10-8-17/h7-10,16,19-22,24,35H,3-6,11-15,30H2,1-2H3,(H,31,39)(H,32,38)(H,36,37)(H,42,43)/p-1/t19-,20-,21-,22-,24+/m1/s1 EHMN_ABBREVIATION: CE4723
initial amount: NaN
constant: false
has only substance units: false
is: http://identifiers.org/pubchem.compound/5041
is: SBO:0000247
is: C01936
boundary condition: false
name: neocasomorphin (1-5)
type: Species

http://identifiers.org/biomodels.db/MODEL1310110042#_f06e5fe6_050e_4ee3_be87_fbed57ba28ef
type: Species
boundary condition: true
is: P49902
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:22978
name: NT5C2
initial concentration: NaN
constant: false
has only substance units: false

metaR SERDGLNexR
modifier: MODEL1310110042#
is: SBO:0000185
kinetic law: MODEL1310110042#
reversible: true
notes: GENE_ASSOCIATION: (56301.1) and (6520.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10734121,PMID:10863037,PMID:14770310 NOTES:
type: Reaction
fast: false
is described by: ECO:0000304
reactant: MODEL1310110042#
product: MODEL1310110042#
name: D-Serine/Glutamine reversible exchange

metaR r0735
product: MODEL1310110042#
is version of: http://identifiers.org/ec-code/1.2.1.3
notes: GENE_ASSOCIATION: (AA081045.1) or (AI620219.1) or (219.1) or (217.1) or (224.1) or (501.1) or (223.1) or (AU149534.1) or (T83654.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.1.38 Confidence Level: 0 AUTHORS: PMID:12654921 NOTES:
is: SBO:0000176
reversible: true
fast: false
is described by: ECO:0000000
type: Reaction
reactant: MODEL1310110042#
name: trans-Dec-2-enoyl-CoA reductase Fatty acid elongation in mitochondria EC:1.3.1.38
kinetic law: MODEL1310110042#
modifier: MODEL1310110042#

http://identifiers.org/biomodels.db/MODEL1310110042#_ac6d9bdc_d535_4e15_a718_6e125870433c
is: P25092
type: Species
initial concentration: NaN
name: GUCY2C
is: SBO:0000252
boundary condition: true
has only substance units: false
constant: false
is encoded by: hsa:2984
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110042#_bb44806f_54b3_459a_be0c_875bcda12b19
is: SBO:0000252
initial amount: NaN
has only substance units: false
initial concentration: NaN
name: NDUFB7
boundary condition: true
is: P17568
constant: false
is encoded by: hsa:4713
type: Species

http://identifiers.org/biomodels.db/MODEL1310110042#_c845131a_5c06_48f4_aa6c_113564368692
type: Species
is: SBO:0000252
initial concentration: NaN
constant: false
has only substance units: false
boundary condition: true
is: B2RB13
is encoded by: hsa:23305
name: ACSL6
initial amount: NaN

metaM lnlnca c
type: Species
name: alpha-linolenate
is: HMDB01388
is: SBO:0000247
initial amount: NaN
has only substance units: false
initial concentration: 1.0
notes: FORMULA: C18H29O2 CHARGE: -1 INCHI: InChI=1S/C18H30O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20/h3-4,6-7,9-10H,2,5,8,11-17H2,1H3,(H,19,20)/p-1/b4-3-,7-6-,10-9-
boundary condition: false
is: CHEBI:32387
constant: false

metaR AG13T2g
product: MODEL1310110042#
name: N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase, Golgi apparatus
fast: false
reversible: false
kinetic law: MODEL1310110042#
is version of: http://identifiers.org/ec-code/2.4.1.149
type: Reaction
reactant: MODEL1310110042#
modifier: MODEL1310110042#
notes: GENE_ASSOCIATION: (79369.1) or (374907.1) or (11041.1) or (146712.1) or (374907.2) or (93010.1) or (10331.1) or (10678.1) or (10678.2) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.149 Confidence Level: 4 AUTHORS: PMID:10747980,PMID:11042166,PMID:12061784,PMID:12512857,PMID:15560372,PMID:15620693,PMID:9405606 NOTES:NCD
is: SBO:0000176
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110042#_49413f47_97b0_4693_bb03_e4b713a8baea
initial concentration: NaN
constant: false
initial amount: NaN
is: SBO:0000252
name: ATP5G2
is encoded by: hsa:517
boundary condition: true
has only substance units: false
type: Species

metaR RE1517M
is version of: http://identifiers.org/ec-code/1.3.3.6
reactant: MODEL1310110042#
notes: GENE_ASSOCIATION: (33.1) or (51.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.99.13 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:11356167,PMID:8973539 NOTES:
is described by: ECO:0000000
product: MODEL1310110042#
fast: false
reversible: true
kinetic law: MODEL1310110042#
name: RE1517
type: Reaction
is: SBO:0000176
modifier: MODEL1310110042#
is version of: http://identifiers.org/ec-code/1.3.99.13

http://identifiers.org/biomodels.db/MODEL1310110042#_4032f8f3_b7fa_42c8_899d_60d486eeb5bf
boundary condition: true
type: Species
is: SBO:0000252
is: Q9BTY2
name: FUCA2
initial concentration: NaN
has only substance units: false
is encoded by: hsa:2519
constant: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110042#_5bd2abc5_ae98_4d34_a57a_bfdc477fde36
constant: false
initial amount: NaN
boundary condition: true
has only substance units: false
type: Species
is encoded by: hsa:2629
is: P04062
initial concentration: NaN
is: SBO:0000252
name: GBA

metaR r1088
product: MODEL1310110042#
reactant: MODEL1310110042#
is described by: ECO:0000000
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:10049700,PMID:10574970,PMID:11389679,PMID:11557028,PMID:11564694,PMID:12824232,PMID:12930836,PMID:14574404,PMID:16288981,PMID:911815 NOTES:
name: Active transport
type: Reaction
is: SBO:0000185
kinetic law: MODEL1310110042#
reversible: true

metaM pglyc hs c
initial amount: NaN
has only substance units: false
name: phosphatidylglycerol(1-)
is: SBO:0000247
initial concentration: 1.0
type: Species
constant: false
notes: FORMULA: C6H12O6PFULLRCO2FULLR2CO2 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC02096
is: CHEBI:60523
boundary condition: false

metaM mev R x
notes: FORMULA: C6H11O4 CHARGE: -1 INCHI: InChI=1S/C6H12O4/c1-6(10,2-3-7)4-5(8)9/h7,10H,2-4H2,1H3,(H,8,9)/p-1/t6-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00343
constant: false
initial concentration: 1.0
has only substance units: false
is: CHEBI:36464
name: (R)-mevalonate
type: Species
is: SBO:0000247
boundary condition: false
is: HMDB00227
initial amount: NaN

metaR EX lac L LPAREN e RPAREN
kinetic law: MODEL1310110042#
reactant: MODEL1310110042#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: L-Lactate exchange
type: Reaction

metaR r1580
reactant: MODEL1310110042#
is described by: ECO:0000000
kinetic law: MODEL1310110042#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
type: Reaction
product: MODEL1310110042#
reversible: true
is: SBO:0000185
fast: false

http://identifiers.org/biomodels.db/MODEL1310110042#_3db7ba18_c3f3_4a8c_8ad5_db3d09b5cabc
type: Species
is encoded by: hsa:3145
is: SBO:0000252
boundary condition: true
is: P08397
has only substance units: false
constant: false
initial concentration: NaN
initial amount: NaN
name: HMBS

metaM pydx5p e
is: CHEBI:597326
has only substance units: false
is: HMDB01491
initial amount: NaN
type: Species
name: pyridoxal 5'-phosphate(2-)
is: SBO:0000247
initial concentration: 1.0
boundary condition: false
notes: FORMULA: C8H8NO6P CHARGE: -2 INCHI: InChI=1S/C8H10NO6P/c1-5-8(11)7(3-10)6(2-9-5)4-15-16(12,13)14/h2-3,11H,4H2,1H3,(H2,12,13,14)/p-2 HEPATONET_1.0_ABBREVIATION: HC00028 EHMN_ABBREVIATION: C00018
constant: false

metaM HC01434 m
initial concentration: 1.0
notes: FORMULA: C6H3O7 CHARGE: -3 INCHI: InChI=1S/C6H6O7/c7-3(8)1-2(5(10)11)4(9)6(12)13/h2H,1H2,(H,7,8)(H,10,11)(H,12,13)/p-3 EHMN_ABBREVIATION: C05379
is: CHEBI:58931
initial amount: NaN
is: SBO:0000247
constant: false
boundary condition: false
name: oxalatosuccinate(3-)
has only substance units: false
type: Species

metaM ak2lgchol hs e
is: C04317
notes: FORMULA: C10H21O5NPFULLR CHARGE: 0 EHMN_ABBREVIATION: C04317
is: SBO:0000247
constant: false
has only substance units: false
initial amount: NaN
initial concentration: 1.0
name: 1-alkyl 2-lysoglycerol 3-phosphocholine
is: http://identifiers.org/pubchem.compound/6975
boundary condition: false
type: Species

metaM frdp x
has only substance units: false
is: CHEBI:175763
boundary condition: false
is: HMDB00961
initial concentration: 1.0
name: farnesyl pyrophosphate(3-)
constant: false
type: Species
is: SBO:0000247
initial amount: NaN
notes: FORMULA: C15H25O7P2 CHARGE: -3 INCHI: InChI=1S/C15H28O7P2/c1-13(2)7-5-8-14(3)9-6-10-15(4)11-12-21-24(19,20)22-23(16,17)18/h7,9,11H,5-6,8,10,12H2,1-4H3,(H,19,20)(H2,16,17,18)/p-3/b14-9+,15-11+ HEPATONET_1.0_ABBREVIATION: HC00362 EHMN_ABBREVIATION: C00448

http://identifiers.org/biomodels.db/MODEL1310110042#_aae5b4b4_b94f_41a5_bb9f_95b62bbf0166
is: SBO:0000252
constant: false
initial concentration: NaN
is: Q13093
name: PLA2G7
boundary condition: true
is encoded by: hsa:7941
has only substance units: false
type: Species
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110042#_76b49c72_8d9b_45ce_ad49_34dd15345bfa
initial amount: NaN
is encoded by: hsa:AA629629
name: _AA629629_1_m
initial concentration: NaN
constant: false
is: SBO:0000252
boundary condition: true
has only substance units: false
type: Species

metaR FAOXC201C181x
kinetic law: MODEL1310110042#
product: MODEL1310110042#
reactant: MODEL1310110042#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta xoidation(C20:1-->C18:1)x
type: Reaction

metaR DOLPGT1 Ler
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (29929.1) SUBSYSTEM: N-glycan synthesis EC Number: Confidence Level: 0 AUTHORS: NOTES:EC 2.4.1.- NCD
modifier: MODEL1310110042#
name: dolichyl-phosphate-glucose-glycolipid alpha-glucosyltransferase (liver)
reversible: false
reactant: MODEL1310110042#
product: MODEL1310110042#
is version of: http://identifiers.org/ec-code/2.4.1.267
type: Reaction
fast: false
kinetic law: MODEL1310110042#
is: SBO:0000176

metaR r1581
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
fast: false
reactant: MODEL1310110042#
is described by: ECO:0000000
product: MODEL1310110042#
type: Reaction
kinetic law: MODEL1310110042#
is: SBO:0000185
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110042#_c2915489_0144_4278_8c12_1d322958d4f9
has only substance units: false
is encoded by: hsa:6391
initial amount: NaN
initial concentration: NaN
boundary condition: true
is encoded by: hsa:6392
has part: P21912
constant: false
has part: O14521
has part: Q99643
is: SBO:0000297
has part: P31040
name: SDHA:SDHB:SDHC:SDHD
is encoded by: hsa:6389
type: Species
is encoded by: hsa:6390

http://identifiers.org/biomodels.db/MODEL1310110042#_d7200fd4_90f7_470f_8220_dce31011db6e
initial amount: NaN
type: Species
is: P06132
is: SBO:0000252
is encoded by: hsa:7389
initial concentration: NaN
has only substance units: false
constant: false
boundary condition: true
name: UROD

metaR LNLCCRNt
reversible: false
name: transport into the mitochondria (carnitine)
type: Reaction
modifier: MODEL1310110042#
is: SBO:0000185
fast: false
product: MODEL1310110042#
notes: GENE_ASSOCIATION: (788.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: NOTES:NJ
is described by: ECO:0000269
kinetic law: MODEL1310110042#
reactant: MODEL1310110042#

metaR NACHEX17ly
fast: false
kinetic law: MODEL1310110042#
reactant: MODEL1310110042#
is version of: http://identifiers.org/ec-code/3.2.1.52
is described by: ECO:0000000
type: Reaction
name: beta-N-acetylhexosaminidase, lysosomal
modifier: MODEL1310110042#
notes: GENE_ASSOCIATION: (3074.1) or (3073.1) or (3073.1 and 3074.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.52 Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12706724,PMID:8993162 NOTES:NCD
reversible: false
product: MODEL1310110042#
is: SBO:0000176

metaR r1987
reactant: MODEL1310110042#
modifier: MODEL1310110042#
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
kinetic law: MODEL1310110042#
is described by: ECO:0000000
product: MODEL1310110042#
fast: false
type: Reaction
reversible: false
name: Y+LAT2 Utilized transport
is: SBO:0000185

metaM CE2839 e
boundary condition: false
is: http://identifiers.org/pubchem.compound/5041
name: maltodecaose
is: C01936
initial concentration: 1.0
constant: false
initial amount: NaN
is: SBO:0000247
notes: FORMULA: C60H102O51 CHARGE: 0 INCHI: InChI=1/C60H102O51/c61-1-11-21(71)22(72)33(83)52(94-11)104-43-13(3-63)96-54(35(85)24(43)74)106-45-15(5-65)98-56(37(87)26(45)76)108-47-17(7-67)100-58(39(89)28(47)78)110-49-19(9-69)102-60(41(91)30(49)80)111-50-20(10-70)101-59(40(90)31(50)81)109-48-18(8-68)99-57(38(88)29(48)79)107-46-16(6-66)97-55(36(86)27(46)77)105-44-14(4-64)95-53(34(84)25(44)75)103-42-12(2-62)93-51(92)32(82)23(42)73/h11-92H,1-10H2/t11-,12-,13-,14-,15-,16-,17-,18-,19-,20-,21+,22+,23-,24-,25-,26-,27-,28-,29-,30-,31-,32+,33+,34+,35+,36+,37+,38+,39+,40+,41+,42+,43+,44+,45+,46+,47+,48+,49+,50+,51u,52+,53+,54+,55+,56+,57+,58+,59+,60+/m1/s1 EHMN_ABBREVIATION: CE2839
type: Species
has only substance units: false

metaM tetdece1crn c
has only substance units: false
type: Species
notes: FORMULA: C21H39NO4 CHARGE: 0
constant: false
initial amount: NaN
is: SBO:0000247
is: HMDB02014
initial concentration: 1.0
boundary condition: false
name: tetradecenoyl carnitine

http://identifiers.org/biomodels.db/MODEL1310110042#_22e56117_bf0d_4666_9115_3d94608a1c75
has only substance units: false
initial concentration: NaN
initial amount: NaN
is: SBO:0000252
boundary condition: true
type: Species
is encoded by: hsa:3948
name: LDHC
constant: false

metaM ak2lgchol hs c
is: SBO:0000247
is: http://identifiers.org/pubchem.compound/6975
has only substance units: false
notes: FORMULA: C10H21O5NPFULLR CHARGE: 0 EHMN_ABBREVIATION: C04317
initial concentration: 1.0
name: 1-alkyl 2-lysoglycerol 3-phosphocholine
type: Species
constant: false
is: C04317
boundary condition: false
initial amount: NaN

metaR r2360
fast: false
is described by: ECO:0000000
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
name: Organic anion transporter 5 Utilized transport
is: SBO:0000185
reversible: true
product: MODEL1310110042#
reactant: MODEL1310110042#
kinetic law: MODEL1310110042#

metaR r2039
kinetic law: MODEL1310110042#
modifier: MODEL1310110042#
is: SBO:0000185
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.15
reactant: MODEL1310110042#
is described by: ECO:0000000
type: Reaction
fast: false
reversible: false
product: MODEL1310110042#

metaM hs deg14 l
has only substance units: false
type: Species
is: SBO:0000247
is: CHEBI:16126
name: heparan sulfate, degradation product 14
constant: false
initial concentration: 1.0
initial amount: NaN
boundary condition: false
notes: FORMULA: C57H84N3O62S5 CHARGE: -7

metaR ACACtx
reversible: true
product: MODEL1310110042#
name: acetoacetate intracellular transport unknown mechanism
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 1 AUTHORS: NOTES:unknown mechanism NJ
type: Reaction
fast: false
kinetic law: MODEL1310110042#
reactant: MODEL1310110042#
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110042#_54b13b27_788b_4342_a55c_16ec7c47a097
initial amount: NaN
has only substance units: false
is: B3KXK1
initial concentration: NaN
is encoded by: hsa:115019
type: Species
name: SLC26A9
is: SBO:0000252
boundary condition: true
constant: false

metaM pydx5p c
is: C00018
boundary condition: false
is: CHEBI:597326
name: Pyridoxal 5'-phosphate
is: SBO:0000247
notes: FORMULA: C8H8NO6P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00028 EHMN_ABBREVIATION: C00018
initial amount: NaN
initial concentration: 1.0
has only substance units: false
constant: false
is: HMDB01491
type: Species

http://identifiers.org/biomodels.db/MODEL1310110042#_61273b91_01a5_4ec8_a48d_e75a4772ffa6
type: Species
name: PCBD1
initial concentration: NaN
initial amount: NaN
boundary condition: true
is: SBO:0000252
has only substance units: false
constant: false
is encoded by: hsa:5092

metaR MI145PP
reactant: MODEL1310110042#
is version of: http://identifiers.org/ec-code/3.1.3.56
is version of: http://identifiers.org/ec-code/3.1.3.36
name: inositol-1,4,5-trisphosphate 5-phosphatase
product: MODEL1310110042#
kinetic law: MODEL1310110042#
modifier: MODEL1310110042#
reversible: false
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (3635.1) or (8867.2) or (3636.1) or (27124.2) or (8867.1) or (27124.1) or (3633.1) or (56623.1) or (3632.1) SUBSYSTEM: Inositol phosphate metabolism EC Number: 3.1.3.56 Confidence Level: 4 AUTHORS: PMID:10593988,PMID:10764818,PMID:15261714,PMID:2906139,PMID:7721860,PMID:8006039,PMID:8013665,PMID:8530088,PMID:8769125,PMID:9428629,PMID:9824312 NOTES:NCD
is version of: http://identifiers.org/ec-code/3.1.3.86
type: Reaction
is: SBO:0000176
fast: false

metaM eipencoa x
constant: false
initial concentration: 1.0
name: 2,5,8,11,14-eicosapentaenoylcoa
notes: FORMULA: C41H60N7O17P3S CHARGE: -4
has only substance units: false
is: http://identifiers.org/pubchem.compound/24892790
boundary condition: false
is: SBO:0000247
type: Species
initial amount: NaN

metaR FAOXC226C227m
kinetic law: MODEL1310110042#
product: MODEL1310110042#
reactant: MODEL1310110042#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C22:6-->C22:7)m
type: Reaction

metaR DOLPMT U
is: SBO:0000176
fast: false
name: Dolichyl-phosphate D-mannosyltransferase (uterus)
kinetic law: MODEL1310110042#
is version of: http://identifiers.org/ec-code/2.4.1.83
reversible: false
is described by: ECO:0000000
type: Reaction
reactant: MODEL1310110042#
product: MODEL1310110042#
modifier: MODEL1310110042#
notes: GENE_ASSOCIATION: (54344.2 and 8818.1 and 8813.1) or (8818.2 and 54344.1 and 8813.1) or (8818.1 and 54344.1 and 8813.1) or (54344.2 and 8818.2 and 8813.1) SUBSYSTEM: N-glycan synthesis EC Number: 2.4.1.83 Confidence Level: 0 AUTHORS: PMID:11420690 NOTES:NCD

metaM hpdcacrn m
notes: FORMULA: C24H47NO4 CHARGE: 0 INCHI: InChI=1/C24H47NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-24(28)29-22(20-23(26)27)21-25(2,3)4/h22H,5-21H2,1-4H3
has only substance units: false
is: SBO:0000247
initial concentration: 1.0
initial amount: NaN
constant: false
boundary condition: false
type: Species
is: HMDB06210
name: heptadecanoyl carnitine

metaR FAOXC16DCr
kinetic law: MODEL1310110042#
product: MODEL1310110042#
reactant: MODEL1310110042#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid activation(C16DC)er
type: Reaction

metaR r2361
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
kinetic law: MODEL1310110042#
reversible: true
fast: false
name: Organic anion transporter 5 Utilized transport
is described by: ECO:0000000
is: SBO:0000185
type: Reaction
product: MODEL1310110042#
reactant: MODEL1310110042#

metaM fdp c
constant: false
initial concentration: 1.0
is: HMDB01058
has only substance units: false
initial amount: NaN
is: CHEBI:16905
is: http://identifiers.org/pubchem.compound/3647
is: SBO:0000247
boundary condition: false
is: C00354
name: D-Fructose 1,6-bisphosphate
notes: FORMULA: C6H10O12P2 CHARGE: -4 INCHI: " HEPATONET_1.0_ABBREVIATION: HC00300 EHMN_ABBREVIATION: C00354
type: Species

metaR NAIt
is: SBO:0000185
notes: GENE_ASSOCIATION: (6528.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10893432,PMID:11034615,PMID:12679487,PMID:12748858,PMID:15546855,PMID:8559252,PMID:8806637,PMID:9341168 NOTES:NCD
product: MODEL1310110042#
type: Reaction
name: Na+ / iodide cotransport
is described by: ECO:0000269
reversible: true
fast: false
kinetic law: MODEL1310110042#
reactant: MODEL1310110042#
modifier: MODEL1310110042#

metaR r1583
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
type: Reaction
product: MODEL1310110042#
is: SBO:0000185
kinetic law: MODEL1310110042#
reversible: true
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reactant: MODEL1310110042#
is described by: ECO:0000000

metaM hs l
name: heparan sulfate, free chain
boundary condition: false
type: Species
has only substance units: false
notes: FORMULA: C79H114N5O102S12 CHARGE: -13
is: SBO:0000247
initial concentration: 1.0
is: CHEBI:28815
constant: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110042#_f07dcfc5_27f2_4ec7_b2c9_bb6a379c4d1f
is: SBO:0000252
is encoded by: hsa:51809
initial concentration: NaN
constant: false
boundary condition: true
type: Species
has only substance units: false
name: GALNT7
initial amount: NaN
is: Q86SF2

http://identifiers.org/biomodels.db/MODEL1310110042#_3695d81c_d167_423e_aa57_4818315d5650
name: DGKZ
is encoded by: hsa:8525
type: Species
initial concentration: NaN
has only substance units: false
constant: false
is: SBO:0000252
initial amount: NaN
boundary condition: true
is: G3V0F6

http://identifiers.org/biomodels.db/MODEL1310110042#_71833719_20b8_4134_bc2f_a9da73695f32
boundary condition: true
is: SBO:0000252
initial amount: NaN
name: SGPL1
is: O95470
initial concentration: NaN
has only substance units: false
constant: false
type: Species
is encoded by: hsa:8879

http://identifiers.org/biomodels.db/MODEL1310110042#_6fe32598_d7d5_47a9_a77c_685cf3880ab1
is: P14555
type: Species
is: SBO:0000252
is encoded by: hsa:5320
constant: false
initial concentration: NaN
name: PLA2G2A
has only substance units: false
boundary condition: true
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110042#_faa6426b_d928_4bc5_b062_392249dfad11
initial amount: NaN
has only substance units: false
initial concentration: NaN
type: Species
is: SBO:0000252
constant: false
is encoded by: hsa:4121
is: P33908
name: MAN1A1
boundary condition: true

metaM phytcoa x
initial amount: NaN
has only substance units: false
name: phytanoyl-CoA(4-)
is: CHEBI:57391
boundary condition: false
constant: false
is: HMDB01359
is: SBO:0000247
initial concentration: 1.0
type: Species
notes: FORMULA: C41H70N7O17P3S CHARGE: -4 INCHI: InChI=1S/C41H74N7O17P3S/c1-26(2)11-8-12-27(3)13-9-14-28(4)15-10-16-29(5)21-32(50)69-20-19-43-31(49)17-18-44-39(53)36(52)41(6,7)23-62-68(59,60)65-67(57,58)61-22-30-35(64-66(54,55)56)34(51)40(63-30)48-25-47-33-37(42)45-24-46-38(33)48/h24-30,34-36,40,51-52H,8-23H2,1-7H3,(H,43,49)(H,44,53)(H,57,58)(H,59,60)(H2,42,45,46)(H2,54,55,56)/p-4/t27?,28?,29?,30-,34-,35-,36+,40-/m1/s1

metaR GALASE17ly
kinetic law: MODEL1310110042#
reversible: false
is version of: http://identifiers.org/ec-code/3.2.1.18
is version of: http://identifiers.org/ec-code/3.2.1.23
reactant: MODEL1310110042#
is: SBO:0000176
is described by: ECO:0000000
type: Reaction
is version of: http://identifiers.org/ec-code/3.4.16.5
modifier: MODEL1310110042#
product: MODEL1310110042#
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) or (5476.1) and (2720.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.23 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD
is version of: http://identifiers.org/ec-code/3.1.6.4
name: beta-galactosidase, lysosomal
fast: false

metaR ACETONEt2
notes: GENE_ASSOCIATION: (6566.1) or (9123.1) or (9194.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10510291,PMID:11101640,PMID:12739169,PMID:7835905,PMID:8476015,PMID:9425115,PMID:9508842,PMID:9649795,PMID:9786900,PMID:9824713 NOTES:NCD
fast: false
name: acetone transport via proton symport
reactant: MODEL1310110042#
product: MODEL1310110042#
modifier: MODEL1310110042#
reversible: true
type: Reaction
kinetic law: MODEL1310110042#
is: SBO:0000185
is described by: ECO:0000269

metaR HSD3A1r
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/1.1.1.225
kinetic law: MODEL1310110042#
modifier: MODEL1310110042#
notes: GENE_ASSOCIATION: (1109.1) SUBSYSTEM: Steroid metabolism EC Number: 1.1.1.225 Confidence Level: 4 AUTHORS: PMID:14643063,PMID:7650035 NOTES:Microsomal rxn see PMID: 14643063 substrate specificity still not clear (nad vs nadp) NJ
product: MODEL1310110042#
is: SBO:0000176
type: Reaction
fast: false
reactant: MODEL1310110042#
reversible: true
name: 3 alpha-hydroxysteroid dehydrogenase (type 3)

metaM acngalgbside hs g
name: sialyl galactosylgloboside
type: Species
notes: FORMULA: C61H105N3O35FULLRCO CHARGE: -1
has only substance units: false
constant: false
initial amount: NaN
boundary condition: false
is: CHEBI:16523
is: SBO:0000247
is: HMDB03406
initial concentration: 1.0

metaM od2coa c
has only substance units: false
is: SBO:0000247
constant: false
boundary condition: false
is: CHEBI:50570
is: HMDB06529
initial amount: NaN
name: trans-Octadec-2-enoyl-CoA
is: C16218
initial concentration: 1.0
type: Species
notes: FORMULA: C39H64N7O17P3S CHARGE: -4 EHMN_ABBREVIATION: CE2244

http://identifiers.org/biomodels.db/MODEL1310110042#_616faae8_2fd5_4a1c_9a36_9b3d22f4e946
is: SBO:0000252
type: Species
constant: false
is encoded by: hsa:6487
has only substance units: false
initial amount: NaN
name: ST3GAL3
initial concentration: NaN
boundary condition: true

metaR EX ump LPAREN e RPAREN
kinetic law: MODEL1310110042#
reactant: MODEL1310110042#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: UMP exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110042#_8efcd35b_b922_4972_befa_e0863c58e80a
is: E7EPT3
initial amount: NaN
initial concentration: NaN
name: ALDH7A1
boundary condition: true
constant: false
is encoded by: hsa:501
is: SBO:0000252
type: Species
has only substance units: false

metaR r1584
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
type: Reaction
fast: false
reactant: MODEL1310110042#
reversible: true
is: SBO:0000185
kinetic law: MODEL1310110042#
product: MODEL1310110042#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is described by: ECO:0000000

metaR CTPtn
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: NOTES:IT
is: SBO:0000185
reactant: MODEL1310110042#
type: Reaction
is described by: ECO:0000000
product: MODEL1310110042#
reversible: true
name: CTP diffusion in nucleus
kinetic law: MODEL1310110042#
fast: false

metaR 3AIBt
reversible: false
type: Reaction
fast: false
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:HOW? IT
kinetic law: MODEL1310110042#
is described by: ECO:0000000
product: MODEL1310110042#
name: 3-amino-isobutyrate transport
reactant: MODEL1310110042#

metaR r1562
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reactant: MODEL1310110042#
fast: false
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is described by: ECO:0000000
kinetic law: MODEL1310110042#
is: SBO:0000185
reversible: true
product: MODEL1310110042#
type: Reaction

metaM c6crn e
type: Species
notes: FORMULA: C13H25NO4 CHARGE: 0
initial amount: NaN
is: SBO:0000247
boundary condition: false
constant: false
is: HMDB00705
name: hexanoyl carnitine
has only substance units: false
initial concentration: 1.0

metaR r2362
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
name: Organic anion transporter 5 Utilized transport
reactant: MODEL1310110042#
is described by: ECO:0000000
type: Reaction
reversible: true
kinetic law: MODEL1310110042#
is: SBO:0000185
fast: false
product: MODEL1310110042#

metaR ODECOAtx
fast: false
is described by: ECO:0000000
type: Reaction
reactant: MODEL1310110042#
product: MODEL1310110042#
reversible: true
kinetic law: MODEL1310110042#
name: fatty acid intracellular transport
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: NOTES:interaction between peroxisomes and ER (some enzymes on the outer membrane) NJ

http://identifiers.org/biomodels.db/MODEL1310110042#_5b506463_141b_428c_ae07_5ce3c9d8c4b4
name: GALNT10
is: SBO:0000252
has only substance units: false
initial concentration: NaN
type: Species
boundary condition: true
is: Q86SR1
is encoded by: hsa:55568
initial amount: NaN
constant: false

http://identifiers.org/biomodels.db/MODEL1310110042#_0cc1d46c_e665_4fc4_a444_c6b926ac8fba
initial amount: NaN
is encoded by: hsa:1666
name: DECR1
is: Q16698
constant: false
boundary condition: true
is: SBO:0000252
has only substance units: false
initial concentration: NaN
type: Species

metaM ksii core4 pre9 g
notes: FORMULA: C83H133N7O64S2X CHARGE: -3
is: CHEBI:28067
constant: false
type: Species
initial amount: NaN
has only substance units: false
initial concentration: 1.0
boundary condition: false
is: SBO:0000247
name: keratan sulfate II biosynthesis, precursor 9

metaM acnam n
type: Species
initial concentration: 1.0
is: SBO:0000247
initial amount: NaN
name: N-acetylneuraminate
constant: false
has only substance units: false
is: CHEBI:35418
is: HMDB00230
boundary condition: false
notes: FORMULA: C11H18NO9 CHARGE: -1 INCHI: InChI=1S/C11H19NO9/c1-4(14)12-7-5(15)2-11(20,10(18)19)21-9(7)8(17)6(16)3-13/h5-9,13,15-17,20H,2-3H2,1H3,(H,12,14)(H,18,19)/p-1/t5-,6+,7+,8+,9+,11?/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00244 EHMN_ABBREVIATION: C00270

metaR r2363
product: MODEL1310110042#
name: Organic anion transporter 5 Utilized transport
reactant: MODEL1310110042#
kinetic law: MODEL1310110042#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
fast: false
is described by: ECO:0000000
type: Reaction
reversible: true

metaR EX gln L LPAREN e RPAREN
kinetic law: MODEL1310110042#
reactant: MODEL1310110042#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for L-glutamine
type: Reaction

metaM tetdecdicoa x
is: HMDB02288
type: Species
constant: false
initial concentration: 1.0
name: 5,8-tetradecadienoylcoa
boundary condition: false
is: SBO:0000247
initial amount: NaN
has only substance units: false
notes: FORMULA: C35H54N7O17P3S CHARGE: -4

metaM thm c
type: Species
notes: FORMULA: C12H17N4OS CHARGE: 1
boundary condition: false
constant: false
initial amount: NaN
is: CHEBI:0
has only substance units: false
is: SBO:0000247
name: Thiamin
is: C00378
initial concentration: 1.0
is: HMDB00235

metaR S6TASE3ly
modifier: MODEL1310110042#
reversible: true
is described by: ECO:0000000
type: Reaction
fast: false
notes: GENE_ASSOCIATION: (2799.1) SUBSYSTEM: Heparan sulfate degradation EC Number: 3.1.6.14 Confidence Level: 4 AUTHORS: PMID:3196333,PMID:3689314,PMID:3689315 NOTES:NCD
is version of: http://identifiers.org/ec-code/3.1.6.14
reactant: MODEL1310110042#
is: SBO:0000176
kinetic law: MODEL1310110042#
name: N-acetylglucosamine-6-sulfatase, lysosomal
product: MODEL1310110042#

metaR C8CRNe
kinetic law: MODEL1310110042#
product: MODEL1310110042#
reactant: MODEL1310110042#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of octanoyl carnitine into the extra cellular space
type: Reaction

metaR r1563
reactant: MODEL1310110042#
kinetic law: MODEL1310110042#
is: SBO:0000185
fast: false
reversible: true
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is described by: ECO:0000000
type: Reaction
product: MODEL1310110042#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:

metaR EX CE5867 LPAREN e RPAREN
kinetic law: MODEL1310110042#
reactant: MODEL1310110042#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: N-acetyl-seryl-aspartyl-lysyl-proline exchange
type: Reaction

metaR r1585
type: Reaction
is described by: ECO:0000000
is: SBO:0000185
reversible: true
reactant: MODEL1310110042#
kinetic law: MODEL1310110042#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
product: MODEL1310110042#

metaM cholcoaone x
initial concentration: 1.0
initial amount: NaN
has only substance units: false
constant: false
is: SBO:0000247
is: HMDB06891
is: CHEBI:58507
boundary condition: false
notes: FORMULA: C48H74N7O21P3S CHARGE: -4 INCHI: InChI=1S/C48H78N7O21P3S/c1-24(28-8-9-29-36-30(19-34(59)48(28,29)6)47(5)13-11-27(56)17-26(47)18-32(36)58)7-10-31(57)25(2)45(64)80-16-15-50-35(60)12-14-51-43(63)40(62)46(3,4)21-73-79(70,71)76-78(68,69)72-20-33-39(75-77(65,66)67)38(61)44(74-33)55-23-54-37-41(49)52-22-53-42(37)55/h22-30,32-34,36,38-40,44,56,58-59,61-62H,7-21H2,1-6H3,(H,50,60)(H,51,63)(H,68,69)(H,70,71)(H2,49,52,53)(H2,65,66,67)/p-4/t24-,25?,26+,27-,28-,29+,30+,32-,33-,34+,36+,38-,39-,40+,44-,47+,48-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01473 EHMN_ABBREVIATION: C05467
name: 3alpha,7alpha,12alpha-trihydroxy-24-oxo-5beta-cholestan-26-oyl-CoA(4-)
type: Species

metaR PROt2r
notes: GENE_ASSOCIATION: (206358.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11390972,PMID:11959859 NOTES:NCD
is: SBO:0000185
modifier: MODEL1310110042#
reactant: MODEL1310110042#
is described by: ECO:0000304
kinetic law: MODEL1310110042#
product: MODEL1310110042#
fast: false
reversible: true
type: Reaction
name: L-proline reversible transport via proton symport

metaM pglyc hs e
boundary condition: false
type: Species
name: phosphatidylglycerol(1-)
is: SBO:0000247
constant: false
has only substance units: false
is: CHEBI:60523
notes: FORMULA: C6H12O6PFULLRCO2FULLR2CO2 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC02096
initial concentration: 1.0
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110042#_1ef45b4c_f9c4_4754_b0b3_e2e601eacc88
constant: false
is: P54868
boundary condition: true
has only substance units: false
type: Species
initial amount: NaN
name: HMGCS2
is encoded by: hsa:3158
is: SBO:0000252
initial concentration: NaN

metaM c6crn c
notes: FORMULA: C13H25NO4 CHARGE: 0
type: Species
boundary condition: false
initial amount: NaN
is: SBO:0000247
constant: false
has only substance units: false
is: HMDB00705
name: hexanoyl carnitine
initial concentration: 1.0

metaR r2364
product: MODEL1310110042#
reactant: MODEL1310110042#
is described by: ECO:0000000
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
name: Organic anion transporter 5 Utilized transport
is: SBO:0000185
reversible: true
fast: false
kinetic law: MODEL1310110042#

metaR r1560
type: Reaction
fast: false
reactant: MODEL1310110042#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
kinetic law: MODEL1310110042#
reversible: true
is described by: ECO:0000000
product: MODEL1310110042#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110042#_ffe68c09_9f8f_4bb4_9eb0_4ddbdfb05c6d
initial amount: NaN
constant: false
is: SBO:0000252
type: Species
has only substance units: false
name: SLC25A26
boundary condition: true
initial concentration: NaN
is encoded by: hsa:115286

metaM dgchol x
is: CHEBI:36252
notes: FORMULA: C26H43NO5 CHARGE: 0 INCHI: InChI=1S/C26H43NO5/c1-15(4-7-22(30)27-14-23(31)32)18-5-6-19-24-20(9-11-26(18,19)3)25(2)10-8-17(28)12-16(25)13-21(24)29/h15-21,24,28-29H,4-14H2,1-3H3,(H,27,30)(H,31,32)/p-1/t15-,16+,17-,18-,19+,20+,21-,24+,25+,26-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01472
name: glycochenodeoxycholate
has only substance units: false
is: SBO:0000247
type: Species
initial concentration: 1.0
is: HMDB00637
initial amount: NaN
constant: false
boundary condition: false

metaM hs deg9 l
is: HMDB06355
type: Species
initial amount: NaN
initial concentration: 1.0
name: heparan sulfate, degradation product 9
has only substance units: false
constant: false
boundary condition: false
is: CHEBI:18268
notes: FORMULA: C61H87N3O76S8 CHARGE: -10
is: SBO:0000247

metaR r1586
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reactant: MODEL1310110042#
kinetic law: MODEL1310110042#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
type: Reaction
is described by: ECO:0000000
fast: false
product: MODEL1310110042#
reversible: true

metaM ksi pre10 g
is: SBO:0000247
initial concentration: 1.0
is: CHEBI:58053
type: Species
notes: FORMULA: C129H209N9O98S2X CHARGE: -3
name: keratan sulfate I biosynthesis, precursor 10
initial amount: NaN
boundary condition: false
constant: false
is: HMDB00175
is: C00130
has only substance units: false

metaR PEt
product: MODEL1310110042#
fast: false
reactant: MODEL1310110042#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11591435,PMID:12814641,PMID:15599942,PMID:1679347,PMID:7487879,PMID:8188243 NOTES:
is described by: ECO:0000000
name: phosphatidylethanolamine transport
kinetic law: MODEL1310110042#
is: SBO:0000185
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110042#_574eff45_afa8_4c83_92ec_809238c92a68
has only substance units: false
is encoded by: hsa:8802
initial amount: NaN
boundary condition: true
has part: Q96I99
has part: P53597
is: SBO:0000297
initial concentration: NaN
type: Species
is encoded by: hsa:8801
constant: false
name: SUCLG2:SUCLG1

http://identifiers.org/biomodels.db/MODEL1310110042#_39b8e77f_7f6f_4137_af78_c34a9499332f
is: SBO:0000297
name: PIGF:PIGO
initial amount: NaN
has only substance units: false
initial concentration: NaN
has part: Q6IB04
type: Species
is encoded by: hsa:84720
constant: false
boundary condition: true
is encoded by: hsa:5281

metaR HISCAT1
kinetic law: MODEL1310110042#
product: MODEL1310110042#
reactant: MODEL1310110042#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: Transport of L-Histidine by y+ transporter
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110042#_7d120f7e_8c3c_45f2_88af_237d6b8fbb97
boundary condition: true
is: SBO:0000252
constant: false
initial concentration: NaN
name: _H17063_1_m
initial amount: NaN
is encoded by: hsa:H17063
has only substance units: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110042#_a1c644a9_1bdb_40b3_87d2_8f2b5c36c4fc
is: A8K3J4
has only substance units: false
initial concentration: NaN
boundary condition: true
constant: false
name: CA14
type: Species
is encoded by: hsa:23632
initial amount: NaN
is: SBO:0000252

metaR r2365
reversible: true
product: MODEL1310110042#
reactant: MODEL1310110042#
name: Organic anion transporter 5 Utilized transport
is: SBO:0000185
fast: false
is described by: ECO:0000000
type: Reaction
kinetic law: MODEL1310110042#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110042#_5db41a52_3576_4aa6_8d3c_79f7d9034fad
name: _AI091231_1_c
is: SBO:0000252
type: Species
boundary condition: true
initial concentration: NaN
has only substance units: false
initial amount: NaN
constant: false
is encoded by: hsa:AI091231

metaR EX ctp LPAREN e RPAREN
kinetic law: MODEL1310110042#
reactant: MODEL1310110042#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of CTP(4-)
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110042#_54403562_bdd1_457b_9665_851f1b08c1ab
has only substance units: false
constant: false
has part: O43292
is encoded by: hsa:10026
is encoded by: hsa:8733
is encoded by: hsa:128869
initial concentration: NaN
is encoded by: hsa:94005
is encoded by: hsa:51604
has part: Q969N2
type: Species
initial amount: NaN
has part: Q9H490
has part: Q92643
has part: Q8NBL9
boundary condition: true
name: PIGK:PIGU:PIGT:GPAA1:PIGS
is: SBO:0000297

metaR r1561
reactant: MODEL1310110042#
reversible: true
type: Reaction
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
kinetic law: MODEL1310110042#
is: SBO:0000185
product: MODEL1310110042#
is described by: ECO:0000000
fast: false

metaR TCYNTt
reactant: MODEL1310110042#
kinetic law: MODEL1310110042#
is: SBO:0000185
type: Reaction
fast: false
reversible: false
name: Thiocyanate transport via diffusion (cytosol to extracellular)
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:6351723 NOTES:thiocyanate is found excreted in urine (PMID: 6351723) MM
product: MODEL1310110042#

metaM 5dpmev x
type: Species
is: CHEBI:15899
is: HMDB01090
has only substance units: false
initial amount: NaN
boundary condition: false
initial concentration: 1.0
notes: FORMULA: C6H10O10P2 CHARGE: -4 INCHI: InChI=1S/C6H14O10P2/c1-6(9,4-5(7)8)2-3-15-18(13,14)16-17(10,11)12/h9H,2-4H2,1H3,(H,7,8)(H,13,14)(H2,10,11,12)/t6-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00685 EHMN_ABBREVIATION: C01143
name: (R)-5-Diphosphomevalonate
constant: false
is: SBO:0000247

metaM tetdece1crn e
initial concentration: 1.0
constant: false
boundary condition: false
has only substance units: false
initial amount: NaN
notes: FORMULA: C21H39NO4 CHARGE: 0
is: SBO:0000247
is: HMDB02014
type: Species
name: tetradecenoyl carnitine

metaR r0308
reactant: MODEL1310110042#
fast: false
is: SBO:0000176
type: Reaction
kinetic law: MODEL1310110042#
reversible: false
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (6576.1) SUBSYSTEM: Fatty acid oxidation EC Number: 3.1.2.22 Confidence Level: 0 AUTHORS: PMID:10092594,PMID:6151837 NOTES:
modifier: MODEL1310110042#
name: Palmitoyl-CoA hydrolase Fatty acid elongation in mitochondria EC:3.1.2.22 EC:3.1.2.2
product: MODEL1310110042#

http://identifiers.org/biomodels.db/MODEL1310110042#_a24c8577_e1bf_4a71_b151_7351da6ea6d7
initial amount: NaN
is: SBO:0000252
type: Species
name: GALT
initial concentration: NaN
constant: false
boundary condition: true
is: B2RAT6
is encoded by: hsa:2592
has only substance units: false

metaR r1587
reactant: MODEL1310110042#
reversible: true
kinetic law: MODEL1310110042#
fast: false
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
product: MODEL1310110042#
type: Reaction
is described by: ECO:0000000
is: SBO:0000185

metaR M7MASNBterg
name: m7masnB transport from endoplasmic reticulum to Golgi apparatus
is described by: ECO:0000000
kinetic law: MODEL1310110042#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: N-glycan synthesis EC Number: Confidence Level: 0 AUTHORS: NOTES:NCD
product: MODEL1310110042#
is: SBO:0000185
reactant: MODEL1310110042#
reversible: false
type: Reaction

metaR r2507
product: MODEL1310110042#
type: Reaction
kinetic law: MODEL1310110042#
reversible: true
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:17466261 NOTES:
is: SBO:0000185
name: Utilized transport
is described by: ECO:0000000
reactant: MODEL1310110042#

metaR FAOXC184C164x
kinetic law: MODEL1310110042#
product: MODEL1310110042#
reactant: MODEL1310110042#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C18:4-->C16:4)x
type: Reaction

metaM leuktrC4 c
is: SBO:0000247
is: HMDB01198
has only substance units: false
initial concentration: 1.0
is: CHEBI:57973
type: Species
boundary condition: false
initial amount: NaN
name: leukotriene C4(2-)
constant: false
notes: FORMULA: C30H45N3O9S CHARGE: -2 INCHI: InChI=1S/C30H47N3O9S/c1-2-3-4-5-6-7-8-9-10-11-12-13-16-25(24(34)15-14-17-27(36)37)43-21-23(29(40)32-20-28(38)39)33-26(35)19-18-22(31)30(41)42/h6-7,9-13,16,22-25,34H,2-5,8,14-15,17-21,31H2,1H3,(H,32,40)(H,33,35)(H,36,37)(H,38,39)(H,41,42)/p-2/b7-6-,10-9-,12-11+,16-13+/t22-,23-,24-,25+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00898 EHMN_ABBREVIATION: C02166

metaR r1588
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reactant: MODEL1310110042#
is: SBO:0000185
product: MODEL1310110042#
fast: false
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
type: Reaction
is described by: ECO:0000000
reversible: true
kinetic law: MODEL1310110042#

metaM zymst r
notes: FORMULA: C27H44O CHARGE: 0 INCHI: InChI=1S/C27H44O/c1-18(2)7-6-8-19(3)23-11-12-24-22-10-9-20-17-21(28)13-15-26(20,4)25(22)14-16-27(23,24)5/h7,19-21,23-24,28H,6,8-17H2,1-5H3/t19-,20+,21+,23-,24+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01451 EHMN_ABBREVIATION: C05437
initial amount: NaN
name: zymosterol
constant: false
is: CHEBI:18252
has only substance units: false
initial concentration: 1.0
is: SBO:0000247
boundary condition: false
type: Species
is: HMDB06271

metaM ppa c
notes: FORMULA: C3H5O2 CHARGE: -1 INCHI: InChI=1S/C3H6O2/c1-2-3(4)5/h2H2,1H3,(H,4,5)/p-1 HEPATONET_1.0_ABBREVIATION: HC00158 EHMN_ABBREVIATION: C00163
name: propionate
is: CHEBI:17272
initial concentration: 1.0
has only substance units: false
type: Species
boundary condition: false
initial amount: NaN
is: SBO:0000247
constant: false
is: HMDB00237

metaR RE3568C
name: RE3568
product: MODEL1310110042#
kinetic law: MODEL1310110042#
reactant: MODEL1310110042#
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Eicosanoid metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:234423 NOTES:
reversible: true
type: Reaction
fast: false
is described by: ECO:0000000

metaR GUACYC
reversible: false
kinetic law: MODEL1310110042#
modifier: MODEL1310110042#
notes: GENE_ASSOCIATION: (2977.1 and 2983.1) or (4882.2) or (2982.1 and 2974.1) or (2986.1) or (4882.1) or (2984.1) or (4881.1) or (2977.1 and 2974.1) or (3000.1) or (2982.1 and 2983.1) SUBSYSTEM: Nucleotide interconversion EC Number: 4.6.1.2 Confidence Level: 4 AUTHORS: PMID:10449911,PMID:10777682,PMID:11565546,PMID:11851379,PMID:1352257,PMID:14748740,PMID:15371450,PMID:7601467,PMID:7761400,PMID:7777544,PMID:7954658,PMID:8838319,PMID:9097965,PMID:9742212 NOTES:IT
is: SBO:0000176
is version of: http://identifiers.org/ec-code/4.6.1.2
reactant: MODEL1310110042#
name: guanylate cyclase
product: MODEL1310110042#
is described by: ECO:0000269
fast: false
type: Reaction

metaR r1566
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reversible: true
reactant: MODEL1310110042#
is described by: ECO:0000000
type: Reaction
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is: SBO:0000185
product: MODEL1310110042#
kinetic law: MODEL1310110042#

metaR GK1
reversible: true
fast: false
product: MODEL1310110042#
is described by: ECO:0000269
type: Reaction
kinetic law: MODEL1310110042#
reactant: MODEL1310110042#
notes: GENE_ASSOCIATION: (2987.1) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: NOTES:
name: guanylate kinase (GMP:ATP)
modifier: MODEL1310110042#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.7.4.8

http://identifiers.org/biomodels.db/MODEL1310110042#_99dfcbb7_2db9_443e_8a2a_ad812d5a110f
initial concentration: NaN
has part: B7Z3U6
boundary condition: true
is encoded by: hsa:483
type: Species
is: SBO:0000297
name: ATP1A1:ATP1B3
is encoded by: hsa:476
initial amount: NaN
constant: false
has only substance units: false
has part: P54709

metaR EX gly LPAREN e RPAREN
kinetic law: MODEL1310110042#
reactant: MODEL1310110042#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for Glycine
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110042#_956f7f66_fcf0_416d_bd86_11e1e538fc31
is encoded by: hsa:6390
name: SDHB
boundary condition: true
constant: false
type: Species
is: SBO:0000252
initial concentration: NaN
has only substance units: false
initial amount: NaN
is: P21912

metaR RE1573M
modifier: MODEL1310110042#
name: RE1573
is version of: http://identifiers.org/ec-code/1.1.1.35
kinetic law: MODEL1310110042#
is described by: ECO:0000000
type: Reaction
fast: false
is: SBO:0000176
reactant: MODEL1310110042#
is version of: http://identifiers.org/ec-code/5.3.3.8
notes: GENE_ASSOCIATION: (1632.1) or (10455.1) or (1962.1) SUBSYSTEM: Fatty acid oxidation EC Number: 5.3.3.8 Confidence Level: 0 AUTHORS: PMID:10407780 NOTES:
product: MODEL1310110042#
reversible: true

metaR r2471
is: SBO:0000185
kinetic law: MODEL1310110042#
fast: false
product: MODEL1310110042#
reactant: MODEL1310110042#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12748860 NOTES:
reversible: false
type: Reaction
is described by: ECO:0000000
name: Major Facilitator(MFS) TCDB:2.A.18.8.1

metaM glac c
notes: FORMULA: C6H8O6 CHARGE: 0 INCHI: InChI=1S/C6H8O6/c7-1-2(8)5-3(9)4(10)6(11)12-5/h1-5,8-10H/t2-,3+,4-,5+/m0/s1
constant: false
name: D-glucurono-6,3-lactone
boundary condition: false
is: HMDB06355
has only substance units: false
initial amount: NaN
type: Species
is: SBO:0000247
initial concentration: 1.0
is: CHEBI:18268

http://identifiers.org/biomodels.db/MODEL1310110042#_b5857264_a20d_444e_9afc_0b8284d1cef8
type: Species
constant: false
is: P04075
initial concentration: NaN
initial amount: NaN
name: ALDOA
is: SBO:0000252
has only substance units: false
is encoded by: hsa:226
boundary condition: true

metaM lac L e
type: Species
notes: FORMULA: C3H5O3 CHARGE: -1 INCHI: InChI=1S/C3H6O3/c1-2(4)3(5)6/h2,4H,1H3,(H,5,6)/p-1/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00177
name: (S)-lactate
initial amount: NaN
constant: false
is: SBO:0000247
initial concentration: 1.0
boundary condition: false
is: HMDB00190
has only substance units: false
is: CHEBI:16651

metaR r1589
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
kinetic law: MODEL1310110042#
product: MODEL1310110042#
reactant: MODEL1310110042#
fast: false
reversible: true
type: Reaction
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110042#_99499e49_0e07_4407_a517_4be5c8c388e4
boundary condition: true
is: P42336
type: Species
initial concentration: NaN
constant: false
has only substance units: false
initial amount: NaN
is encoded by: hsa:5290
is: SBO:0000252
name: PIK3CA

http://identifiers.org/biomodels.db/MODEL1310110042#_4e0ee35c_bb82_4941_94f1_8434f6041edd
name: RDH5
boundary condition: true
has only substance units: false
initial concentration: NaN
is: SBO:0000252
is: Q92781
is encoded by: hsa:5959
type: Species
initial amount: NaN
constant: false

metaR r2506
kinetic law: MODEL1310110042#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:17466261 NOTES:
is: SBO:0000185
name: Utilized transport
type: Reaction
reactant: MODEL1310110042#
reversible: true
product: MODEL1310110042#
is described by: ECO:0000000

metaR ACHEe
name: Acetylcholinesterase
reactant: MODEL1310110042#
fast: false
modifier: MODEL1310110042#
is version of: http://identifiers.org/ec-code/3.1.1.7
is: SBO:0000176
kinetic law: MODEL1310110042#
notes: GENE_ASSOCIATION: (43.1) or (43.2) SUBSYSTEM: Glycerophospholipid metabolism EC Number: 3.1.1.7 Confidence Level: 4 AUTHORS: PMID:11283752,PMID:1517212 NOTES:NJ
product: MODEL1310110042#
reversible: false
type: Reaction
is described by: ECO:0000269

metaR TYRTA
type: Reaction
is: SBO:0000176
name: tyrosine transaminase
product: MODEL1310110042#
reversible: true
is version of: http://identifiers.org/ec-code/2.6.1.1
kinetic law: MODEL1310110042#
is described by: ECO:0000269
modifier: MODEL1310110042#
fast: false
reactant: MODEL1310110042#
notes: GENE_ASSOCIATION: (2805.1) SUBSYSTEM: Tyrosine metabolism EC Number: 2.6.1.5 Confidence Level: 4 AUTHORS: NOTES:

http://identifiers.org/biomodels.db/MODEL1310110042#_377d9549_4098_4aa9_951b_2ed6e73ca4e4
is: SBO:0000252
is: E7EML0
type: Species
constant: false
initial concentration: NaN
boundary condition: true
initial amount: NaN
has only substance units: false
name: SLC4A8
is encoded by: hsa:9498

metaR r1567
reversible: true
kinetic law: MODEL1310110042#
is: SBO:0000185
reactant: MODEL1310110042#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is described by: ECO:0000000
type: Reaction
fast: false
product: MODEL1310110042#

metaR OLEICFATPtc
kinetic law: MODEL1310110042#
product: MODEL1310110042#
reactant: MODEL1310110042#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: uptake of octadecenoate by the enterocytes
type: Reaction

metaR C161CRN2t
product: MODEL1310110042#
kinetic law: MODEL1310110042#
is: SBO:0000185
reactant: MODEL1310110042#
reversible: false
modifier: MODEL1310110042#
type: Reaction
fast: false
notes: GENE_ASSOCIATION: (788.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: NOTES:NJ
is described by: ECO:0000269
name: C161 transport into the mitochondria

metaM gcald c
is: CHEBI:17071
initial amount: NaN
initial concentration: 1.0
is: SBO:0000247
has only substance units: false
notes: FORMULA: C2H4O2 CHARGE: 0 INCHI: InChI=1S/C2H4O2/c3-1-2-4/h1,4H,2H2 EHMN_ABBREVIATION: C00266
type: Species
name: glycolaldehyde
constant: false
is: HMDB03344
boundary condition: false

metaM cspg b l
boundary condition: false
constant: false
type: Species
initial concentration: 1.0
is: HMDB02183
has only substance units: false
initial amount: NaN
is: CHEBI:36005
name: chondroitin sulfate B / dermatan sulfate (IdoA2S-GalNAc4S) proteoglycan
is: SBO:0000247
notes: FORMULA: C45H65N2O48S4X CHARGE: -6

http://identifiers.org/biomodels.db/MODEL1310110042#_05705cf8_e4e7_4d43_9410_d1c0fb43c71e
type: Species
name: DGKI
constant: false
has only substance units: false
is: SBO:0000252
initial amount: NaN
boundary condition: true
initial concentration: NaN
is encoded by: hsa:9162
is: O75912

metaR C5DCe
kinetic law: MODEL1310110042#
product: MODEL1310110042#
reactant: MODEL1310110042#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of glutaryl carnitine into the extra cellular fluid
type: Reaction

metaM cs e deg4 l
notes: FORMULA: C31H46NO38S4 CHARGE: -5
type: Species
is: SBO:0000247
is: HMDB00127
initial amount: NaN
constant: false
is: CHEBI:15748
has only substance units: false
initial concentration: 1.0
boundary condition: false
name: chondroitin sulfate E (GalNAc4,6diS-GlcA), degradation product 4

http://identifiers.org/biomodels.db/MODEL1310110042#_7ffd08f5_3ea0_490a_9042_4293ef167d71
initial amount: NaN
constant: false
is: SBO:0000252
has only substance units: false
type: Species
initial concentration: NaN
boundary condition: true
is encoded by: hsa:956
name: ENTPD3
is: O75355

metaR LYStn
fast: false
name: L-lysine transport, nuclear
type: Reaction
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: NOTES:IT
product: MODEL1310110042#
reactant: MODEL1310110042#
is: SBO:0000185
kinetic law: MODEL1310110042#
reversible: true

metaR EX Rtotal3 LPAREN e RPAREN
kinetic law: MODEL1310110042#
reactant: MODEL1310110042#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: R total 3 position exchange
type: Reaction

metaM ppa e
notes: FORMULA: C3H5O2 CHARGE: -1 INCHI: InChI=1S/C3H6O2/c1-2-3(4)5/h2H2,1H3,(H,4,5)/p-1 HEPATONET_1.0_ABBREVIATION: HC00158 EHMN_ABBREVIATION: C00163
initial concentration: 1.0
name: propionate
type: Species
initial amount: NaN
has only substance units: false
is: SBO:0000247
boundary condition: false
constant: false
is: HMDB00237
is: CHEBI:17272

metaM leuktrC4 e
is: CHEBI:57973
type: Species
has only substance units: false
initial concentration: 1.0
initial amount: NaN
boundary condition: false
constant: false
name: leukotriene C4(2-)
is: SBO:0000247
is: HMDB01198
notes: FORMULA: C30H45N3O9S CHARGE: -2 INCHI: InChI=1S/C30H47N3O9S/c1-2-3-4-5-6-7-8-9-10-11-12-13-16-25(24(34)15-14-17-27(36)37)43-21-23(29(40)32-20-28(38)39)33-26(35)19-18-22(31)30(41)42/h6-7,9-13,16,22-25,34H,2-5,8,14-15,17-21,31H2,1H3,(H,32,40)(H,33,35)(H,36,37)(H,38,39)(H,41,42)/p-2/b7-6-,10-9-,12-11+,16-13+/t22-,23-,24-,25+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00898 EHMN_ABBREVIATION: C02166

metaR G3PD2m
reactant: MODEL1310110042#
notes: GENE_ASSOCIATION: (2820.1) SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: 1.1.99.5 Confidence Level: 2 AUTHORS: PMID:11385633,PMID:8549872 NOTES:replaces old version which contains redundant metabolite (gly3p) NCD split compartmentation NJ
kinetic law: MODEL1310110042#
type: Reaction
is: SBO:0000185
is version of: http://identifiers.org/ec-code/1.1.5.3
fast: false
modifier: MODEL1310110042#
product: MODEL1310110042#
is described by: ECO:0000304
reversible: false
name: glycerol-3-phosphate dehydrogenase (FAD), mitochondrial

http://identifiers.org/biomodels.db/MODEL1310110042#_dd73ef73_019e_4732_b5eb_387f14841ab9
constant: false
initial concentration: NaN
is: SBO:0000252
is: B4DYG5
has only substance units: false
name: PI4KA
initial amount: NaN
boundary condition: true
type: Species
is encoded by: hsa:5297

metaR r1564
reversible: true
reactant: MODEL1310110042#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is described by: ECO:0000000
fast: false
type: Reaction
kinetic law: MODEL1310110042#
product: MODEL1310110042#
is: SBO:0000185
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1

metaM HC01434 c
has only substance units: false
constant: false
initial amount: NaN
is: CHEBI:58931
type: Species
initial concentration: 1.0
boundary condition: false
is: SBO:0000247
name: oxalatosuccinate(3-)
notes: FORMULA: C6H3O7 CHARGE: -3 INCHI: InChI=1S/C6H6O7/c7-3(8)1-2(5(10)11)4(9)6(12)13/h2H,1H2,(H,7,8)(H,10,11)(H,12,13)/p-3 EHMN_ABBREVIATION: C05379

http://identifiers.org/biomodels.db/MODEL1310110042#_f5a8a0e4_61db_4f77_affd_d0942df3c92f
is encoded by: hsa:U52111
name: _U52111_1_c
initial amount: NaN
has only substance units: false
initial concentration: NaN
type: Species
is: SBO:0000252
constant: false
boundary condition: true

metaM lac L c
boundary condition: false
constant: false
name: (S)-lactate
is: SBO:0000247
has only substance units: false
is: CHEBI:16651
notes: FORMULA: C3H5O3 CHARGE: -1 INCHI: InChI=1S/C3H6O3/c1-2(4)3(5)6/h2,4H,1H3,(H,5,6)/p-1/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00177
initial concentration: 1.0
initial amount: NaN
type: Species
is: HMDB00190

http://identifiers.org/biomodels.db/MODEL1310110042#_abae4272_bb27_4d54_a8f8_e630d1578c28
name: DPYSL2
is: B4DR31
type: Species
initial concentration: NaN
has only substance units: false
is encoded by: hsa:1808
constant: false
boundary condition: true
initial amount: NaN
is: SBO:0000252

metaR ARACHt
is described by: ECO:0000000
product: MODEL1310110042#
fast: false
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11788354,PMID:12864740 NOTES:NJ
reversible: true
type: Reaction
kinetic law: MODEL1310110042#
reactant: MODEL1310110042#
name: fatty acid transport via diffusion

metaR r1565
reactant: MODEL1310110042#
fast: false
reversible: true
is: SBO:0000185
kinetic law: MODEL1310110042#
product: MODEL1310110042#
is described by: ECO:0000000
type: Reaction
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110042#_20cc30a4_cc29_4f25_8850_59fe72de58db
name: _H77542_1_c
initial concentration: NaN
type: Species
is: SBO:0000252
is encoded by: hsa:H77542
has only substance units: false
initial amount: NaN
constant: false
boundary condition: true

metaM frdp r
is: CHEBI:175763
notes: FORMULA: C15H25O7P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00362 EHMN_ABBREVIATION: C00448
boundary condition: false
constant: false
is: C00448
name: Farnesyl diphosphate
type: Species
initial concentration: 1.0
is: HMDB00961
is: SBO:0000247
initial amount: NaN
has only substance units: false

metaM ksii core4 pre5 g
initial concentration: 1.0
constant: false
name: keratan sulfate II biosynthesis, precursor 5
is: CHEBI:58053
boundary condition: false
is: SBO:0000247
type: Species
has only substance units: false
notes: FORMULA: C69H112N6O48X CHARGE: -1
is: HMDB00175
is: C00130
initial amount: NaN

metaM acnam l
boundary condition: false
notes: FORMULA: C11H18NO9 CHARGE: -1 INCHI: InChI=1S/C11H19NO9/c1-4(14)12-7-5(15)2-11(20,10(18)19)21-9(7)8(17)6(16)3-13/h5-9,13,15-17,20H,2-3H2,1H3,(H,12,14)(H,18,19)/p-1/t5-,6+,7+,8+,9+,11?/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00244 EHMN_ABBREVIATION: C00270
is: HMDB00230
initial amount: NaN
constant: false
has only substance units: false
name: N-acetylneuraminate
is: SBO:0000247
is: CHEBI:35418
type: Species
initial concentration: 1.0

metaM glygn4 e
constant: false
notes: FORMULA: C18H31O16X CHARGE: 0
initial amount: NaN
type: Species
initial concentration: 1.0
has only substance units: false
name: glycogen, structure 4 (glycogenin-1,6-{2[1,4-Glc], [1,4-Glc]})
is: CHEBI:4167
is: HMDB00122
is: SBO:0000247
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110042#_896860bd_a48b_49f8_a685_f0bc828ecd91
name: ST3GAL3
initial concentration: NaN
is: SBO:0000252
constant: false
boundary condition: true
is encoded by: hsa:6487
type: Species
initial amount: NaN
is: Q5T4Y1
has only substance units: false

metaM arachcoa c
boundary condition: false
is: CHEBI:15527
constant: false
type: Species
initial concentration: 1.0
is: SBO:0000247
notes: FORMULA: C41H70N7O17P3S CHARGE: -4 INCHI: InChI=1S/C41H74N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-32(50)69-25-24-43-31(49)22-23-44-39(53)36(52)41(2,3)27-62-68(59,60)65-67(57,58)61-26-30-35(64-66(54,55)56)34(51)40(63-30)48-29-47-33-37(42)45-28-46-38(33)48/h28-30,34-36,40,51-52H,4-27H2,1-3H3,(H,43,49)(H,44,53)(H,57,58)(H,59,60)(H2,42,45,46)(H2,54,55,56)/t30-,34-,35-,36+,40-/m1/s1 EHMN_ABBREVIATION: C02041
name: arachidyl coenzyme A
is: HMDB04258
initial amount: NaN
has only substance units: false

metaR r0464
reversible: true
type: Reaction
kinetic law: MODEL1310110042#
notes: GENE_ASSOCIATION: SUBSYSTEM: Glutamate metabolism EC Number: 1.2.1.3 Confidence Level: 0 AUTHORS: PMID:10467734,PMID:11790142,PMID:4817964,PMID:8155713,PMID:8645224,PMID:8786138 NOTES:
product: MODEL1310110042#
fast: false
is: SBO:0000176
is described by: ECO:0000000
name: 4-Aminobutyraldehyde:NAD+ oxidoreductase Urea cycle and metabolism of amino groups EC:1.2.1.3
reactant: MODEL1310110042#

http://identifiers.org/biomodels.db/MODEL1310110042#_05cd86c1_beea_4d2a_8614_142bce89e0e2
name: ME1
is: SBO:0000252
has only substance units: false
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:4199
constant: false
type: Species
boundary condition: true
is: P48163

http://identifiers.org/biomodels.db/MODEL1310110042#_dfb69ebf_8cea_4db7_ab3b_3a68667b486e
is: Q86SK9
initial amount: NaN
is: SBO:0000252
initial concentration: NaN
boundary condition: true
is encoded by: hsa:79966
constant: false
type: Species
has only substance units: false
name: SCD5

metaR Ser Thrtg
fast: false
kinetic law: MODEL1310110042#
name: Ser/Thr transport (from golgi to lysosome)
is: SBO:0000185
reactant: MODEL1310110042#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 1 AUTHORS: PMID:10811962,PMID:11161786 NOTES:
is described by: ECO:0000269
reversible: true
product: MODEL1310110042#

metaR 5ADTSTSTERONESte
reactant: MODEL1310110042#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 1 AUTHORS: NOTES:unknown mechanism - presumed excretion of sulfonated testosterone NJ
product: MODEL1310110042#
is: SBO:0000185
type: Reaction
fast: false
kinetic law: MODEL1310110042#
is described by: ECO:0000000
name: sulfonated testosterone transport
reversible: true

metaM clpndcoa x
is: HMDB06267
boundary condition: false
initial amount: NaN
type: Species
has only substance units: false
initial concentration: 1.0
is: SBO:0000247
name: clupanodonyl CoA
is: C16166
is: http://identifiers.org/pubchem.compound/47205476
constant: false
notes: FORMULA: C43H64N7O17P3S CHARGE: -4 INCHI: InChI=1/C43H68N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-34(52)71-27-26-45-33(51)24-25-46-41(55)38(54)43(2,3)29-64-70(61,62)67-69(59,60)63-28-32-37(66-68(56,57)58)36(53)42(65-32)50-31-49-35-39(44)47-30-48-40(35)50/h5-6,8-9,11-12,14-15,17-18,30-32,36-38,42,53-54H,4,7,10,13,16,19-29H2,1-3H3,(H,45,51)(H,46,55)(H,59,60)(H,61,62)(H2,44,47,48)(H2,56,57,58)/p-4/b6-5-,9-8-,12-11-,15-14-,18-17-/t32-,36+,37+,38?,42-/m0/s1

metaR GLNS
is version of: http://identifiers.org/ec-code/4.1.1.15
is: SBO:0000176
kinetic law: MODEL1310110042#
name: glutamine synthetase
reactant: MODEL1310110042#
fast: false
is described by: ECO:0000254
product: MODEL1310110042#
reversible: false
notes: GENE_ASSOCIATION: (2752.1) or (51557.1) SUBSYSTEM: Glutamate metabolism EC Number: Confidence Level: 2 AUTHORS: NOTES:
modifier: MODEL1310110042#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110042#_0a1ef23f_5421_433b_8722_83da5cb0f520
is: SBO:0000252
boundary condition: true
is encoded by: hsa:290
name: ANPEP
has only substance units: false
initial amount: NaN
initial concentration: NaN
constant: false
is: Q59E93
type: Species

metaR RE3624M
reactant: MODEL1310110042#
reversible: false
modifier: MODEL1310110042#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (51.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.3.6 Confidence Level: 0 AUTHORS: PMID:11356164,PMID:7775433 NOTES:
product: MODEL1310110042#
kinetic law: MODEL1310110042#
fast: false
type: Reaction
is: SBO:0000176
name: RE3624
is version of: http://identifiers.org/ec-code/1.3.3.6

metaR GLNLASEer
reversible: true
reactant: MODEL1310110042#
is described by: ECO:0000000
name: gluconolactonase, endoplasmic reticulum
is: SBO:0000176
product: MODEL1310110042#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Vitamin C metabolism EC Number: 3.1.1.17 Confidence Level: 2 AUTHORS: PMID:9296457 NOTES:NCD
fast: false
kinetic law: MODEL1310110042#

http://identifiers.org/biomodels.db/MODEL1310110042#_1a542938_c6f2_4cae_ae72_e1e1f1c18f04
initial concentration: NaN
initial amount: NaN
name: PIGT
constant: false
is: Q969N2
is: SBO:0000252
has only substance units: false
boundary condition: true
is encoded by: hsa:51604
type: Species

metaR DSAT
type: Reaction
reactant: MODEL1310110042#
fast: false
is: SBO:0000176
kinetic law: MODEL1310110042#
is described by: ECO:0000000
product: MODEL1310110042#
name: dihydrosphingosine N-acyltransferase
notes: GENE_ASSOCIATION: SUBSYSTEM: Sphingolipid metabolism EC Number: Confidence Level: 2 AUTHORS: NOTES:CoA transfer not explicitly in rxn (accounted for in Rtotal rxn -> ARTF) NJ
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110042#_a56f88a5_4895_4106_9618_be782d5fb05c
initial amount: NaN
boundary condition: true
constant: false
is encoded by: hsa:W74642
initial concentration: NaN
name: _W74642_1_c
type: Species
is: SBO:0000252
has only substance units: false

metaR r0463
is: SBO:0000176
is described by: ECO:0000000
kinetic law: MODEL1310110042#
product: MODEL1310110042#
reversible: true
type: Reaction
fast: false
name: (S)-3-Hydroxy-3-methylglutaryl-CoA acetoacetyl-CoA-lyase (CoA-acetylating) Synthesis and degradation of ketone bodies / Valine, leucine and isoleucine degradation / Butanoate metabolism EC:2.3.3.10
reactant: MODEL1310110042#
notes: GENE_ASSOCIATION: SUBSYSTEM: Cholesterol metabolism EC Number: 2.3.3.10 Confidence Level: 0 AUTHORS: PMID:11087424,PMID:11108725,PMID:1358203,PMID:7893153 NOTES:

metaM memgacpail hs r
is: SBO:0000247
initial amount: NaN
initial concentration: 1.0
notes: FORMULA: C45H84N2O27P2FULLRCO2FULLR2CO2 CHARGE: 0
has only substance units: false
constant: false
is: CHEBI:15809
boundary condition: false
name: (mannosyl),(phosphoethanolaminyl)-mannosyl-glucosylaminyl-acylphosphatidylinositol (B)
type: Species

metaM noncoa m
name: nonanoylcoa
is: HMDB13028
initial concentration: 1.0
notes: FORMULA: C30H48N7O17P3S CHARGE: -4
is: SBO:0000247
constant: false
boundary condition: false
has only substance units: false
is: C01942
type: Species
initial amount: NaN

metaR PTPATe
reactant: MODEL1310110042#
is: SBO:0000176
name: PTPATe
type: Reaction
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
product: MODEL1310110042#
kinetic law: MODEL1310110042#
fast: false
is described by: ECO:0000134

http://identifiers.org/biomodels.db/MODEL1310110042#_7b7de082_8d12_459d_afcc_cb148bad7ac8
is: Q92535
initial amount: NaN
is encoded by: hsa:5279
type: Species
boundary condition: true
initial concentration: NaN
name: PIGC
is: SBO:0000252
has only substance units: false
constant: false

metaR S6T12g
modifier: MODEL1310110042#
name: galactose/N-acetylglucosamine 6-O-sulfotransferase, Golgi apparatus
is: SBO:0000176
reactant: MODEL1310110042#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (23563.1) or (9435.1) or (10164.1) or (4166.1) or (23563.2) SUBSYSTEM: Keratan sulfate synthesis EC Number: Confidence Level: 4 AUTHORS: PMID:10330415,PMID:10491328,PMID:10913333,PMID:11278593,PMID:12403612,PMID:12855678,PMID:9722682 NOTES:NCD
product: MODEL1310110042#
kinetic law: MODEL1310110042#
fast: false
reversible: false
type: Reaction

metaR r1568
fast: false
product: MODEL1310110042#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
kinetic law: MODEL1310110042#
is described by: ECO:0000000
type: Reaction
is: SBO:0000185
reversible: true
reactant: MODEL1310110042#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1

metaR ALDD21
notes: GENE_ASSOCIATION: (224.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 2 AUTHORS: PMID:11591435,PMID:8528251 NOTES:NJ
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.2.1.3
modifier: MODEL1310110042#
reversible: false
reactant: MODEL1310110042#
type: Reaction
kinetic law: MODEL1310110042#
name: aldehyde dehydrogenase (pristanal, NAD)
fast: false
is described by: ECO:0000304
product: MODEL1310110042#

metaM cyan c
is: CHEBI:18407
is: SBO:0000247
initial amount: NaN
notes: FORMULA: CHN CHARGE: 0 INCHI: InChI=1S/CHN/c1-2/h1H EHMN_ABBREVIATION: C01326
initial concentration: 1.0
boundary condition: false
has only substance units: false
type: Species
constant: false
is: HMDB02084
name: hydrogen cyanide

metaR PI45P5P
is described by: ECO:0000000
fast: false
modifier: MODEL1310110042#
is: SBO:0000176
notes: GENE_ASSOCIATION: (8867.1) or (56623.1) or (4952.1) or (8871.1) or (8867.2) or (4952.2) or (3633.1) SUBSYSTEM: Inositol phosphate metabolism EC Number: 3.1.3.36 Confidence Level: 4 AUTHORS: PMID:10764818,PMID:12915445,PMID:7721860,PMID:7761412 NOTES:NCD
is version of: http://identifiers.org/ec-code/3.1.3.36
product: MODEL1310110042#
name: phosphatidylinositol-4,5-bisphosphate 5-phosphatase
reversible: false
reactant: MODEL1310110042#
type: Reaction
kinetic law: MODEL1310110042#

metaR RE1530C
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Pyrimidine synthesis EC Number: 2.7.1.21 Confidence Level: 0 AUTHORS: PMID:11812127 NOTES:
is described by: ECO:0000000
kinetic law: MODEL1310110042#
reactant: MODEL1310110042#
product: MODEL1310110042#
name: RE1530
is: SBO:0000176
type: Reaction
reversible: true

metaR TSULt4 3
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (6561.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10811962,PMID:11161786 NOTES:NCD
reactant: MODEL1310110042#
modifier: MODEL1310110042#
product: MODEL1310110042#
type: Reaction
fast: false
reversible: true
is: SBO:0000185
kinetic law: MODEL1310110042#
name: thiosulfate transport via sodium symport

http://identifiers.org/biomodels.db/MODEL1310110042#_6f13e7f8_02b6_433f_b29a_46f74fdc4cd2
type: Species
initial concentration: NaN
is: SBO:0000252
constant: false
name: TM7SF2
is encoded by: hsa:7108
is: O76062
initial amount: NaN
boundary condition: true
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110042#_7737336a_0ec3_4a72_93c3_ac0a137dd2e2
boundary condition: true
name: INPP5E
has only substance units: false
initial concentration: NaN
initial amount: NaN
is: SBO:0000252
is: Q9NRR6
constant: false
is encoded by: hsa:56623
type: Species

http://identifiers.org/biomodels.db/MODEL1310110042#_2bde93eb_0306_41b4_bd3f_78ea4d149315
boundary condition: true
initial amount: NaN
has only substance units: false
constant: false
is: SBO:0000252
type: Species
name: HMGCR
is encoded by: hsa:3156
is: P04035
initial concentration: NaN

metaR r2509
reactant: MODEL1310110042#
type: Reaction
kinetic law: MODEL1310110042#
is: SBO:0000185
product: MODEL1310110042#
reversible: true
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:17466261 NOTES:
is described by: ECO:0000000
name: Utilized transport

metaR LYStm
modifier: MODEL1310110042#
is described by: ECO:0000269
reversible: true
notes: GENE_ASSOCIATION: (83884.1) or (10166.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172 NOTES:TDV
type: Reaction
product: MODEL1310110042#
reactant: MODEL1310110042#
name: Lysine mitochondrial transport via ornithine carrier
is: SBO:0000185
fast: false
kinetic law: MODEL1310110042#

metaR DCK2n
fast: false
is: SBO:0000176
is described by: ECO:0000269
modifier: MODEL1310110042#
type: Reaction
reversible: true
is version of: http://identifiers.org/ec-code/2.7.1.74
kinetic law: MODEL1310110042#
reactant: MODEL1310110042#
name: Deoxycytidine kinase, nuclear (UTP)
notes: GENE_ASSOCIATION: (1633.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.1.74 Confidence Level: 4 AUTHORS: PMID:10387103,PMID:12535661,PMID:9342341 NOTES:IT (2.7.1.74)
product: MODEL1310110042#

http://identifiers.org/biomodels.db/MODEL1310110042#_821a56db_045e_481d_8d06_afd261c74137
constant: false
is: B4DPV0
name: PGM1
initial amount: NaN
is: SBO:0000252
has only substance units: false
boundary condition: true
is encoded by: hsa:5236
initial concentration: NaN
type: Species

http://identifiers.org/biomodels.db/MODEL1310110042#_5e05085c_9c21_4730_82d2_deb2e65386ec
name: HKDC1
type: Species
has only substance units: false
is: B3KT70
is: SBO:0000252
initial concentration: NaN
constant: false
is encoded by: hsa:80201
initial amount: NaN
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110042#_294b6df0_cb02_41dd_8d0e_2f3b3d82cb3d
type: Species
constant: false
is: SBO:0000252
is encoded by: hsa:AGPAT7
initial amount: NaN
name: _AGPAT7_1_c
boundary condition: true
initial concentration: NaN
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110042#_9820e15b_5575_41b2_a904_a33e3d05eea0
initial concentration: NaN
constant: false
type: Species
initial amount: NaN
name: NME2
is: SBO:0000252
is encoded by: hsa:4831
boundary condition: true
is: P22392
has only substance units: false

metaM dolp U r
type: Species
has only substance units: false
initial concentration: 1.0
boundary condition: false
initial amount: NaN
notes: FORMULA: C1025H1670O40P10 CHARGE: -20 INCHI: InChI=1S/C25H45O4P/c1-21(2)11-7-12-22(3)13-8-14-23(4)15-9-16-24(5)17-10-18-25(6)19-20-29-30(26,27)28/h11,13,15,17,25H,7-10,12,14,16,18-20H2,1-6H3,(H2,26,27,28)/p-2/b22-13+,23-15+,24-17- EHMN_ABBREVIATION: C00110
is: CHEBI:57683
constant: false
name: dolichyl phosphate(2-)
is: SBO:0000247

metaR MANt1r
notes: GENE_ASSOCIATION: (6513.1) or (6515.1) or (6514.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:11882499,PMID:12135767,PMID:12750891,PMID:1701966,PMID:2182619,PMID:3103217,PMID:3399500,PMID:3839598,PMID:7926364,PMID:9770484 NOTES:NCD
is: SBO:0000185
reactant: MODEL1310110042#
name: mannose transport (uniport)
kinetic law: MODEL1310110042#
type: Reaction
fast: false
reversible: true
is described by: ECO:0000269
product: MODEL1310110042#
modifier: MODEL1310110042#

metaR r1569
product: MODEL1310110042#
reversible: true
is: SBO:0000185
kinetic law: MODEL1310110042#
reactant: MODEL1310110042#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is described by: ECO:0000000
fast: false
type: Reaction
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1

metaR RE3243R
name: RE3243
notes: GENE_ASSOCIATION: (64834.1) SUBSYSTEM: Fatty acid synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:10970790,PMID:11567032,PMID:2114179 NOTES:
modifier: MODEL1310110042#
reactant: MODEL1310110042#
is: SBO:0000176
fast: false
reversible: true
type: Reaction
kinetic law: MODEL1310110042#
is described by: ECO:0000000
product: MODEL1310110042#

metaR FUCASE2ly
is version of: http://identifiers.org/ec-code/3.2.1.51
is described by: ECO:0000000
reactant: MODEL1310110042#
name: alpha-fucosidase, lysosomal
type: Reaction
product: MODEL1310110042#
kinetic law: MODEL1310110042#
modifier: MODEL1310110042#
reversible: false
notes: GENE_ASSOCIATION: (2517.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.51 Confidence Level: 4 AUTHORS: PMID:11870229,PMID:1769200,PMID:2803312,PMID:2983333 NOTES:NCD
is: SBO:0000176
fast: false

metaR r2508
kinetic law: MODEL1310110042#
is described by: ECO:0000000
product: MODEL1310110042#
is: SBO:0000185
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:17466261 NOTES:
type: Reaction
name: Utilized transport
reactant: MODEL1310110042#
reversible: true

metaR SFGTH
name: S-Formylglutathione hydralase
kinetic law: MODEL1310110042#
is: SBO:0000176
reversible: true
modifier: MODEL1310110042#
notes: GENE_ASSOCIATION: (2098.1) SUBSYSTEM: Tyrosine metabolism EC Number: 3.1.2.12 Confidence Level: 4 AUTHORS: PMID:4436331,PMID:8460164 NOTES:NCD
fast: false
product: MODEL1310110042#
is described by: ECO:0000269
type: Reaction
reactant: MODEL1310110042#
is version of: http://identifiers.org/ec-code/3.1.2.12

http://identifiers.org/biomodels.db/MODEL1310110042#_b518dde7_572f_4a6d_8e2c_49c70432719c
is: P00338
is encoded by: hsa:3939
constant: false
name: LDHA
type: Species
initial concentration: NaN
has only substance units: false
boundary condition: true
is: SBO:0000252
initial amount: NaN

metaM pyr c
constant: false
is: C00022
is: http://identifiers.org/pubchem.compound/3324
boundary condition: false
initial concentration: 1.0
notes: FORMULA: C3H3O3 CHARGE: -1
is: HMDB00243
type: Species
initial amount: NaN
is: SBO:0000247
name: pyruvate
has only substance units: false
is: CHEBI:15361

metaR PRO Dtde
type: Reaction
is: SBO:0000185
is described by: ECO:0000134
fast: false
reactant: MODEL1310110042#
kinetic law: MODEL1310110042#
reversible: true
name: D-proline transport, extracellular
product: MODEL1310110042#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 1 AUTHORS: added during gap-filling. Diffusion into the blood is assumed. NOTES:added during gap-filling. Diffusion into the blood is assumed.

metaR APOC LYS BTNPm
is described by: ECO:0000000
reactant: MODEL1310110042#
name: proteolysis of apoC-Lys-btn, mitochondrial
notes: GENE_ASSOCIATION: SUBSYSTEM: Biotin metabolism EC Number: Confidence Level: 2 AUTHORS: NOTES:
fast: false
product: MODEL1310110042#
reversible: false
is: SBO:0000176
kinetic law: MODEL1310110042#
type: Reaction

metaR GLYCt
product: MODEL1310110042#
type: Reaction
fast: false
is: SBO:0000185
kinetic law: MODEL1310110042#
name: glycerol transport via channel
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:9405233 NOTES:NCD
is described by: ECO:0000000
reactant: MODEL1310110042#
reversible: true

metaR FUCASEe
notes: GENE_ASSOCIATION: (2519.1) SUBSYSTEM: N-glycan degradation EC Number: 3.2.1.51 Confidence Level: 0 AUTHORS: NOTES:NCD
modifier: MODEL1310110042#
product: MODEL1310110042#
reactant: MODEL1310110042#
name: alpha-fucosidase, extracellular
is version of: http://identifiers.org/ec-code/3.2.1.51
is described by: ECO:0000000
type: Reaction
reversible: false
kinetic law: MODEL1310110042#
fast: false
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110042#_bc343b41_fcf9_4b1b_97a4_30b167d23400
name: AFMID
is encoded by: hsa:125061
initial amount: NaN
is: SBO:0000252
initial concentration: NaN
has only substance units: false
type: Species
boundary condition: true
is: Q63HM1
constant: false

http://identifiers.org/biomodels.db/MODEL1310110042#_31041b21_074f_42af_9c2a_b5f5485d9bad
is: SBO:0000252
has only substance units: false
is: Q02221
is encoded by: hsa:1339
initial concentration: NaN
boundary condition: true
name: COX6A2
type: Species
constant: false
initial amount: NaN

metaM gly c
boundary condition: false
type: Species
is: SBO:0000247
is: C00037
is: HMDB00123
initial concentration: 1.0
name: Glycine
is: CHEBI:3339
initial amount: NaN
has only substance units: false
constant: false
notes: FORMULA: C2H5NO2 CHARGE: 0

metaM malt c
is: C00208
has only substance units: false
notes: FORMULA: C12H22O11 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00194 EHMN_ABBREVIATION: C00208
is: SBO:0000247
is: CHEBI:17306
boundary condition: false
initial concentration: 1.0
type: Species
name: Maltose
is: HMDB00163
initial amount: NaN
constant: false

metaR EX lpchol hs LPAREN e RPAREN
kinetic law: MODEL1310110042#
reactant: MODEL1310110042#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for lysophosphatidylcholine
type: Reaction

metaR RE3074X
reversible: true
type: Reaction
is version of: http://identifiers.org/ec-code/6.2.1.3
notes: GENE_ASSOCIATION: (11001.1) or (2182.1) or (2181.1) or (2180.1) or (51703.1) or (23305.1) SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 0 AUTHORS: PMID:11060359,PMID:11356164 NOTES:IT - fixed proton
modifier: MODEL1310110042#
reactant: MODEL1310110042#
is: SBO:0000176
fast: false
product: MODEL1310110042#
name: RE3074
is described by: ECO:0000000
kinetic law: MODEL1310110042#

http://identifiers.org/biomodels.db/MODEL1310110042#_cabb8b76_0ae7_4c4a_9bf1_9320deb51d06
is: Q9NX14
name: NDUFB11
initial concentration: NaN
has only substance units: false
boundary condition: true
is: SBO:0000252
is encoded by: hsa:54539
initial amount: NaN
type: Species
constant: false

metaR L LACt4r
reversible: true
name: L-lactate reversible transport via sodium symport
is described by: ECO:0000000
is: SBO:0000185
reactant: MODEL1310110042#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:8476015,PMID:9425115 NOTES:
fast: false
kinetic law: MODEL1310110042#
product: MODEL1310110042#

metaM dcmp c
is: C00239
is: CHEBI:57566
constant: false
name: dCMP
is: HMDB01202
notes: FORMULA: C9H12N3O7P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00217 EHMN_ABBREVIATION: C00239
is: SBO:0000247
has only substance units: false
initial concentration: 1.0
type: Species
initial amount: NaN
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110042#_29618de9_38e2_4e77_8f97_abea3db176aa
has only substance units: false
type: Species
constant: false
initial amount: NaN
is: P36542
is: SBO:0000252
is encoded by: hsa:509
name: ATP5C1
initial concentration: NaN
boundary condition: true

metaM ppi n
is: CHEBI:33019
constant: false
initial amount: NaN
boundary condition: false
type: Species
is: HMDB00250
has only substance units: false
notes: FORMULA: HO7P2 CHARGE: -3 INCHI: InChI=1S/H4O7P2/c1-8(2,3)7-9(4,5)6/h(H2,1,2,3)(H2,4,5,6)/p-3 HEPATONET_1.0_ABBREVIATION: HC00023 EHMN_ABBREVIATION: C00013
is: SBO:0000247
initial concentration: 1.0
name: diphosphate(3-)

metaR FAOXC246226x
product: MODEL1310110042#
is version of: http://identifiers.org/ec-code/2.3.1.16
is: SBO:0000176
is described by: ECO:0000000
kinetic law: MODEL1310110042#
reactant: MODEL1310110042#
type: Reaction
notes: GENE_ASSOCIATION: (3295.1 and 30.1 and 51.2) or (51.1 and 3295.1 and 30.1) or (30.1 and 51.2 and 1962.1) or (51.1 and 30.1 and 1962.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.74 Confidence Level: 4 AUTHORS: NOTES:peroxisomal (very long chain FA) - - in peroxisome, no fad, 1ste set of beta-ox is by acyl-coa oxidase (passes electrons directly to o2 -> h2o2) c24:6 -> c22:6 4 step FAO lumped also includes EC 1.1.1.35, 1.1.1.211, 1.3.3.6, 4.2.1.17, 4.2.1.74 NJ
is version of: http://identifiers.org/ec-code/4.2.1.107
modifier: MODEL1310110042#
is version of: http://identifiers.org/ec-code/1.1.1.35
fast: false
is version of: http://identifiers.org/ec-code/1.3.3.6
name: Beta oxidation of long chain fatty acid
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110042#_a1db3747_bcc5_4785_8d62_727889922f2a
initial concentration: NaN
has only substance units: false
boundary condition: true
is: P30084
is: SBO:0000252
type: Species
name: ECHS1
is encoded by: hsa:1892
constant: false
initial amount: NaN

metaR S4TASE4ly
is: SBO:0000176
type: Reaction
fast: false
reversible: true
is version of: http://identifiers.org/ec-code/3.1.6.12
product: MODEL1310110042#
name: N-acetylgalactosamine-4-sulfatase, lysosomal
reactant: MODEL1310110042#
notes: GENE_ASSOCIATION: (411.1) or (411.2) SUBSYSTEM: Chondroitin sulfate degradation EC Number: 3.1.6.12 Confidence Level: 4 AUTHORS: PMID:1968043,PMID:2303452 NOTES:NCD
kinetic law: MODEL1310110042#
modifier: MODEL1310110042#
is described by: ECO:0000000

metaM CE2416 x
type: Species
initial concentration: 1.0
is: SBO:0000247
notes: FORMULA: C19H37O2 CHARGE: -1 INCHI: InChI=1/C19H38O2/c1-15(2)9-6-10-16(3)11-7-12-17(4)13-8-14-18(5)19(20)21/h15-18H,6-14H2,1-5H3,(H,20,21)/p-1/t16-,17-,18+/m0/s1 EHMN_ABBREVIATION: CE2416
is: CHEBI:57923
boundary condition: false
has only substance units: false
name: (2R,6S,10S)-pristanate
initial amount: NaN
constant: false

metaM pail hs c
initial amount: NaN
constant: false
initial concentration: 1.0
notes: FORMULA: C9H16O9PFULLRCO2FULLR2CO2 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC02009 EHMN_ABBREVIATION: C01194
has only substance units: false
name: 1-phosphatidyl-1D-myo-inositol(1-)
is: SBO:0000247
type: Species
boundary condition: false
is: CHEBI:57880

metaM 3hpcoa m
has only substance units: false
initial concentration: 1.0
name: 3-hydroxypropanoyl-CoA(4-)
notes: FORMULA: C24H36N7O18P3S CHARGE: -4 INCHI: InChI=1S/C24H40N7O18P3S/c1-24(2,19(36)22(37)27-5-3-14(33)26-6-8-53-15(34)4-7-32)10-46-52(43,44)49-51(41,42)45-9-13-18(48-50(38,39)40)17(35)23(47-13)31-12-30-16-20(25)28-11-29-21(16)31/h11-13,17-19,23,32,35-36H,3-10H2,1-2H3,(H,26,33)(H,27,37)(H,41,42)(H,43,44)(H2,25,28,29)(H2,38,39,40)/p-4/t13-,17-,18-,19+,23-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01557 EHMN_ABBREVIATION: C05668
is: HMDB06807
is: CHEBI:58528
constant: false
boundary condition: false
is: SBO:0000247
type: Species
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110042#_4817afcb_5e1d_4267_9e38_c26ab8f2ae34
has only substance units: false
initial amount: NaN
initial concentration: NaN
constant: false
is: SBO:0000252
type: Species
name: ALDH1L1
is: O75891
boundary condition: true
is encoded by: hsa:10840

http://identifiers.org/biomodels.db/MODEL1310110042#_6367c45a_c9d8_4ebe_bb6c_efdabd06e7a3
has only substance units: false
boundary condition: true
is encoded by: hsa:10317
is: SBO:0000252
constant: false
initial concentration: NaN
initial amount: NaN
type: Species
name: B3GALT5

metaR PYDXNK
fast: false
modifier: MODEL1310110042#
reactant: MODEL1310110042#
notes: GENE_ASSOCIATION: (8566.1) SUBSYSTEM: Vitamin B6 metabolism EC Number: Confidence Level: 4 AUTHORS: NOTES:
is: SBO:0000176
product: MODEL1310110042#
is version of: http://identifiers.org/ec-code/2.7.1.35
reversible: false
name: pyridoxine kinase
is described by: ECO:0000269
type: Reaction
kinetic law: MODEL1310110042#

metaM ddcacoa x
constant: false
type: Species
is: HMDB03571
initial concentration: 1.0
has only substance units: false
name: Dodecanoyl-CoA (n-C12:0CoA)
is: C01832
boundary condition: false
notes: FORMULA: C33H54N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00850 EHMN_ABBREVIATION: C01832
is: SBO:0000247
is: CHEBI:57375
initial amount: NaN

metaR 4ABUTtm
reactant: MODEL1310110042#
fast: false
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: PMID:10407778 NOTES:NCD
product: MODEL1310110042#
is described by: ECO:0000000
reversible: true
kinetic law: MODEL1310110042#
type: Reaction
name: 4-aminobutanoate mitochondrial transport via diffusion

metaM ppi m
initial amount: NaN
boundary condition: false
notes: FORMULA: HO7P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00023 EHMN_ABBREVIATION: C00013
is: SBO:0000247
name: Diphosphate
initial concentration: 1.0
has only substance units: false
is: CHEBI:33019
is: C00013
type: Species
constant: false
is: HMDB00250

metaR FAOXC163C143m
kinetic law: MODEL1310110042#
product: MODEL1310110042#
reactant: MODEL1310110042#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C16:3-->C14:3)m
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110042#_2adca915_d751_4e58_b81a_f33d0eaea0ec
initial concentration: NaN
boundary condition: true
has only substance units: false
name: COX4I2
constant: false
is encoded by: hsa:84701
type: Species
is: SBO:0000252
initial amount: NaN
is: Q96KJ9

metaR r0280
reversible: false
is: SBO:0000176
name: dATP:pyruvate O2-phosphotransferase Purine metabolism EC:2.7.1.40
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (6576.1) SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: 2.7.1.40 Confidence Level: 0 AUTHORS: PMID:1009117,PMID:7154942 NOTES:
reactant: MODEL1310110042#
modifier: MODEL1310110042#
product: MODEL1310110042#
kinetic law: MODEL1310110042#
type: Reaction
fast: false

http://identifiers.org/biomodels.db/MODEL1310110042#_3b6e1830_5668_4532_aa67_f9bd476366b4
is: SBO:0000252
boundary condition: true
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:AI640625
type: Species
constant: false
name: _AI640625_1_c
has only substance units: false

metaM prostgh2 c
boundary condition: false
is: CHEBI:57405
notes: FORMULA: C20H31O5 CHARGE: -1 INCHI: InChI=1S/C20H32O5/c1-2-3-6-9-15(21)12-13-17-16(18-14-19(17)25-24-18)10-7-4-5-8-11-20(22)23/h4,7,12-13,15-19,21H,2-3,5-6,8-11,14H2,1H3,(H,22,23)/p-1/b7-4-,13-12+/t15-,16+,17+,18-,19+/m0/s1 EHMN_ABBREVIATION: C00427
name: prostaglandin H2(1-)
initial concentration: 1.0
is: SBO:0000247
is: HMDB01381
constant: false
has only substance units: false
type: Species
initial amount: NaN

metaM inost c
is: SBO:0000247
is: HMDB00211
boundary condition: false
type: Species
is: CHEBI:17268
has only substance units: false
initial amount: NaN
notes: FORMULA: C6H12O6 CHARGE: 0 INCHI: InChI=1S/C6H12O6/c7-1-2(8)4(10)6(12)5(11)3(1)9/h1-12H/t1-,2-,3-,4+,5-,6- HEPATONET_1.0_ABBREVIATION: HC00135 EHMN_ABBREVIATION: C00137
constant: false
initial concentration: 1.0
name: myo-inositol

metaM apoC c
is: CHEBI:29060
boundary condition: false
notes: FORMULA: XH CHARGE: 0
name: Apocarboxlase (no lys residue)
constant: false
is: HMDB03667
initial amount: NaN
initial concentration: 1.0
is: SBO:0000247
has only substance units: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110042#_1a6296d1_cc5b_47d4_af02_f955e4193c4e
initial concentration: NaN
constant: false
initial amount: NaN
is encoded by: hsa:10599
type: Species
is: SBO:0000252
name: SLCO1B1
has only substance units: false
boundary condition: true
is: Q9Y6L6

metaM caro e
is: HMDB00561
notes: FORMULA: C40H56 CHARGE: 0 INCHI: InChI=1S/C40H56/c1-31(19-13-21-33(3)25-27-37-35(5)23-15-29-39(37,7)8)17-11-12-18-32(2)20-14-22-34(4)26-28-38-36(6)24-16-30-40(38,9)10/h11-14,17-22,25-28H,15-16,23-24,29-30H2,1-10H3/b12-11+,19-13+,20-14+,27-25+,28-26+,31-17+,32-18+,33-21+,34-22+ EHMN_ABBREVIATION: C02094
is: SBO:0000247
name: beta-carotene
has only substance units: false
is: CHEBI:17579
boundary condition: false
initial amount: NaN
type: Species
initial concentration: 1.0
constant: false

metaR NaKt
reactant: MODEL1310110042#
name: Na+/K+ exchanging ATPase
fast: false
product: MODEL1310110042#
notes: GENE_ASSOCIATION: (481.1 and 478.1) or (477.1 and 23439.1) or (483.1 and 476.1) or (481.1 and 480.1) or (482.1 and 478.1) or (482.1 and 476.1) or (482.1 and 477.1) or (481.1 and 476.1) or (23439.1 and 476.1) or (480.1 and 23439.1) or (481.1 and 477.1) SUBSYSTEM: Transport, extracellular EC Number: 3.6.3.9 Confidence Level: 4 AUTHORS: PMID:10456317,PMID:8833915,PMID:9159180 NOTES:AMF TDV (8/25/2005, stoichiometry changed)
kinetic law: MODEL1310110042#
reversible: false
is version of: http://identifiers.org/ec-code/3.6.3.9
type: Reaction
is: SBO:0000185
modifier: MODEL1310110042#
is described by: ECO:0000269

http://identifiers.org/biomodels.db/MODEL1310110042#_2685338e_3031_4365_892f_f55db8d13a34
has only substance units: false
name: SLC28A3
initial amount: NaN
initial concentration: NaN
boundary condition: true
constant: false
is: Q9HAS3
is encoded by: hsa:64078
is: SBO:0000252
type: Species

metaR C161CPT22
reversible: false
name: C161 transport into the mitochondria
is version of: http://identifiers.org/ec-code/2.3.1.21
reactant: MODEL1310110042#
modifier: MODEL1310110042#
is described by: ECO:0000269
type: Reaction
is: SBO:0000176
kinetic law: MODEL1310110042#
product: MODEL1310110042#
notes: GENE_ASSOCIATION: (1376.1) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.21 Confidence Level: 4 AUTHORS: NOTES:NJ
fast: false

metaM hyptaur c
name: Hypotaurine
notes: FORMULA: C2H7NO2S CHARGE: 0 INCHI: InChI=1S/C2H7NO2S/c3-1-2-6(4)5/h1-3H2,(H,4,5) HEPATONET_1.0_ABBREVIATION: HC00406 EHMN_ABBREVIATION: C00519
has only substance units: false
is: SBO:0000247
constant: false
boundary condition: false
initial amount: NaN
type: Species
is: CHEBI:16668
is: HMDB00965
initial concentration: 1.0

metaR FAOXC16080m
modifier: MODEL1310110042#
notes: GENE_ASSOCIATION: (35.1) or (34.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.74 Confidence Level: 4 AUTHORS: NOTES:_4 rounds of beta ox c16:0 -> c8:0, 4 step FAO lumped for 2 rounds also includes EC 1.1.1.35, 1.1.1.211, 1.3.3.6, 4.2.1.17, 4.2.1.74 NJ
is: SBO:0000176
reversible: false
product: MODEL1310110042#
type: Reaction
is version of: http://identifiers.org/ec-code/1.3.8.1
kinetic law: MODEL1310110042#
name: Beta oxidation of long chain fatty acid
is described by: ECO:0000269
fast: false
is version of: http://identifiers.org/ec-code/1.3.99.3
reactant: MODEL1310110042#

metaR MELATNOX
modifier: MODEL1310110042#
is described by: ECO:0000269
fast: false
name: Melatonin:NADP oxidoreductase
kinetic law: MODEL1310110042#
reactant: MODEL1310110042#
reversible: false
is version of: http://identifiers.org/ec-code/1.14.13.48
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.14.14.1
product: MODEL1310110042#
notes: GENE_ASSOCIATION: (1557.1) or (1543.1) or (1545.1) or (1544.1) SUBSYSTEM: Tryptophan metabolism EC Number: 1.14.14.1 Confidence Level: 4 AUTHORS: PMID:15616152 NOTES:SAB made up name
type: Reaction

metaM gullac r
notes: FORMULA: C6H10O6 CHARGE: 0 INCHI: InChI=1S/C6H10O6/c7-1-2(8)5-3(9)4(10)6(11)12-5/h2-5,7-10H,1H2/t2-,3+,4-,5+/m0/s1
has only substance units: false
is: SBO:0000247
initial amount: NaN
is: CHEBI:17587
constant: false
is: HMDB03466
name: L-gulono-1,4-lactone
initial concentration: 1.0
type: Species
boundary condition: false

metaR GLB1
is version of: http://identifiers.org/ec-code/3.2.1.23
is described by: ECO:0000000
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.2.1.18
reactant: MODEL1310110042#
modifier: MODEL1310110042#
is version of: http://identifiers.org/ec-code/3.4.16.5
type: Reaction
reversible: false
is version of: http://identifiers.org/ec-code/3.1.6.4
fast: false
product: MODEL1310110042#
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) or (5476.1) and (2720.1) SUBSYSTEM: Sphingolipid metabolism EC Number: 3.2.1.23 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NJ
kinetic law: MODEL1310110042#
name: Beta-galactosidase

metaM 4hbz m
notes: FORMULA: C7H5O3 CHARGE: -1 INCHI: InChI=1S/C7H6O3/c8-6-3-1-5(2-4-6)7(9)10/h1-4,8H,(H,9,10)/p-1
boundary condition: false
type: Species
is: CHEBI:17879
is: HMDB00500
initial concentration: 1.0
is: SBO:0000247
constant: false
initial amount: NaN
name: 4-hydroxybenzoate
has only substance units: false

metaR FUMtm
kinetic law: MODEL1310110042#
product: MODEL1310110042#
reactant: MODEL1310110042#
is: SBO:0000185
name: fumarate transport, mitochondrial
is described by: ECO:0000269
type: Reaction
modifier: MODEL1310110042#
notes: GENE_ASSOCIATION: (1468.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172,PMID:3587497 NOTES:TDV
fast: false
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110042#_32ac3c87_ea51_4aa0_95d3_7f7c282ccf37
type: Species
boundary condition: true
initial amount: NaN
constant: false
initial concentration: NaN
has only substance units: false
is: SBO:0000252
name: ALDH4A1
is encoded by: hsa:8659

metaR PROSTGH2t
reactant: MODEL1310110042#
is described by: ECO:0000269
type: Reaction
reversible: true
kinetic law: MODEL1310110042#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:12827517,PMID:12883891,PMID:9187257 NOTES:
product: MODEL1310110042#
name: Prostaglandin H2 transport
is: SBO:0000185

metaR CEPTE
kinetic law: MODEL1310110042#
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (10390.1) SUBSYSTEM: Glycerophospholipid metabolism EC Number: Confidence Level: 4 AUTHORS: NOTES:NJ
name: ethanolamine phosphotransferase
reversible: false
type: Reaction
is version of: http://identifiers.org/ec-code/2.7.8.2
is: SBO:0000176
fast: false
product: MODEL1310110042#
modifier: MODEL1310110042#
reactant: MODEL1310110042#

metaM accoa g
notes: FORMULA: C23H34N7O17P3S CHARGE: -4 INCHI: InChI=1S/C23H38N7O17P3S/c1-12(31)51-7-6-25-14(32)4-5-26-21(35)18(34)23(2,3)9-44-50(41,42)47-49(39,40)43-8-13-17(46-48(36,37)38)16(33)22(45-13)30-11-29-15-19(24)27-10-28-20(15)30/h10-11,13,16-18,22,33-34H,4-9H2,1-3H3,(H,25,32)(H,26,35)(H,39,40)(H,41,42)(H2,24,27,28)(H2,36,37,38)/p-4/t13-,16-,17-,18+,22-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00033 EHMN_ABBREVIATION: C00024
has only substance units: false
is: HMDB01206
initial amount: NaN
boundary condition: false
is: CHEBI:57288
initial concentration: 1.0
type: Species
name: acetyl-CoA(4-)
constant: false
is: SBO:0000247

metaR sink dd2coa LPAREN c RPAREN
kinetic law: MODEL1310110042#
reactant: MODEL1310110042#
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: DD2COASINK
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110042#_050a496a_3b17_427b_835a_75d3fc28e348
is: SBO:0000252
initial amount: NaN
constant: false
boundary condition: true
type: Species
is encoded by: hsa:8802
has only substance units: false
name: SUCLG1
initial concentration: NaN
is: P53597

metaR FCOAH
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 2 AUTHORS: PMID:11341778,PMID:11591435 NOTES:Note - formcoa formula is uncharged - the correct is FACOAH2 w/ forcoa NJ
fast: false
name: formyl coa hydrolase
is described by: ECO:0000000
reversible: false
reactant: MODEL1310110042#
type: Reaction
is: SBO:0000176
product: MODEL1310110042#
kinetic law: MODEL1310110042#

metaM xyl D e
notes: FORMULA: C5H10O5 CHARGE: 0 INCHI: InChI=1S/C5H10O5/c6-1-3(8)5(10)4(9)2-7/h1,3-5,7-10H,2H2/t3-,4+,5+/m0/s1
initial concentration: 1.0
has only substance units: false
type: Species
name: aldehydo-D-xylose
constant: false
is: SBO:0000247
initial amount: NaN
is: CHEBI:15936
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110042#_123ec670_a94d_493b_ab24_2bf84dc23258
constant: false
is: SBO:0000252
is encoded by: hsa:55089
boundary condition: true
initial concentration: NaN
is: Q969I6
type: Species
has only substance units: false
initial amount: NaN
name: SLC38A4

metaR S23T2g
kinetic law: MODEL1310110042#
name: beta-galactoside alpha-2,3-sialyltransferase (core 2)
fast: false
notes: GENE_ASSOCIATION: (6484.1) or (6482.1) or (6483.1) or (6482.2) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.99.4 Confidence Level: 4 AUTHORS: PMID:10504389,PMID:7901202,PMID:8027041,PMID:8288606,PMID:8920913 NOTES:NCD
is: SBO:0000176
reactant: MODEL1310110042#
type: Reaction
is version of: http://identifiers.org/ec-code/2.4.99.4
product: MODEL1310110042#
modifier: MODEL1310110042#
reversible: false
is described by: ECO:0000000

metaM prostgh2 e
boundary condition: false
is: CHEBI:57405
notes: FORMULA: C20H31O5 CHARGE: -1 INCHI: InChI=1S/C20H32O5/c1-2-3-6-9-15(21)12-13-17-16(18-14-19(17)25-24-18)10-7-4-5-8-11-20(22)23/h4,7,12-13,15-19,21H,2-3,5-6,8-11,14H2,1H3,(H,22,23)/p-1/b7-4-,13-12+/t15-,16+,17+,18-,19+/m0/s1 EHMN_ABBREVIATION: C00427
is: SBO:0000247
is: HMDB01381
initial concentration: 1.0
name: prostaglandin H2(1-)
constant: false
type: Species
initial amount: NaN
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110042#_07bb29b8_288a_4bac_99cd_c926937e54ff
name: SLC26A1
has only substance units: false
constant: false
is: SBO:0000252
initial concentration: NaN
initial amount: NaN
type: Species
boundary condition: true
is encoded by: hsa:10861

metaR EX caro LPAREN e RPAREN
kinetic law: MODEL1310110042#
reactant: MODEL1310110042#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: beta-Carotene exchange
type: Reaction

metaM inost e
is: HMDB00211
has only substance units: false
constant: false
notes: FORMULA: C6H12O6 CHARGE: 0 INCHI: InChI=1S/C6H12O6/c7-1-2(8)4(10)6(12)5(11)3(1)9/h1-12H/t1-,2-,3-,4+,5-,6- HEPATONET_1.0_ABBREVIATION: HC00135 EHMN_ABBREVIATION: C00137
is: CHEBI:17268
initial amount: NaN
is: SBO:0000247
type: Species
initial concentration: 1.0
boundary condition: false
name: myo-inositol

metaM din e
notes: FORMULA: C10H12N4O4 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC01493 EHMN_ABBREVIATION: C05512
initial concentration: 1.0
initial amount: NaN
boundary condition: false
has only substance units: false
type: Species
is: HMDB00071
is: C05512
constant: false
is: CHEBI:28997
is: SBO:0000247
name: Deoxyinosine

metaM acetone e
has only substance units: false
boundary condition: false
is: CHEBI:15347
type: Species
constant: false
is: SBO:0000247
name: acetone
notes: FORMULA: C3H6O CHARGE: 0 INCHI: InChI=1S/C3H6O/c1-3(2)4/h1-2H3 HEPATONET_1.0_ABBREVIATION: HC00193 EHMN_ABBREVIATION: C00207
initial concentration: 1.0
is: HMDB01659
initial amount: NaN

metaR SUCCt2m
notes: GENE_ASSOCIATION: (1468.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172 NOTES:TDV
reactant: MODEL1310110042#
reversible: true
is: SBO:0000185
name: succinate transport, mitochondrial
is described by: ECO:0000269
type: Reaction
kinetic law: MODEL1310110042#
modifier: MODEL1310110042#
product: MODEL1310110042#
fast: false

metaM 2hb e
is: HMDB00008
constant: false
initial amount: NaN
initial concentration: 1.0
type: Species
is: SBO:0000247
boundary condition: false
name: 2-Hydroxybutyrate
is: CHEBI:1148
has only substance units: false
notes: FORMULA: C4H7O3 CHARGE: -1 INCHI: InChI=1S/C4H8O3/c1-2-3(5)4(6)7/h3,5H,2H2,1H3,(H,6,7) HEPATONET_1.0_ABBREVIATION: HC01669 EHMN_ABBREVIATION: C05984

http://identifiers.org/biomodels.db/MODEL1310110042#_dddfc343_a509_4617_9b01_5b4715da46a7
is: P14854
name: COX6B1
has only substance units: false
type: Species
is encoded by: hsa:1340
is: SBO:0000252
constant: false
initial concentration: NaN
initial amount: NaN
boundary condition: true

metaR EX nrpphrsf LPAREN e RPAREN
kinetic law: MODEL1310110042#
reactant: MODEL1310110042#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Sulfate derivative of norepinephrine exchange
type: Reaction

metaM 5dhf e
is: SBO:0000247
constant: false
notes: FORMULA: C39H43N11O18 CHARGE: -6 INCHI: InChI=1/C39H47N11O18/c40-39-49-31-30(33(58)50-39)43-19(16-42-31)15-41-18-3-1-17(2-4-18)32(57)48-24(38(67)68)8-13-28(54)46-22(36(63)64)6-11-26(52)44-20(34(59)60)5-10-25(51)45-21(35(61)62)7-12-27(53)47-23(37(65)66)9-14-29(55)56/h1-4,16,20-24,41H,5-15H2,(H,44,52)(H,45,51)(H,46,54)(H,47,53)(H,48,57)(H,55,56)(H,59,60)(H,61,62)(H,63,64)(H,65,66)(H,67,68)(H3,40,42,49,50,58)/t20-,21-,22-,23-,24-/m0/s1
name: pentaglutamyl folate (DHF)
type: Species
boundary condition: false
initial concentration: 1.0
has only substance units: false
is: HMDB06487
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110042#_f3fca59c_fa37_4920_a3c6_bfec01d70ef9
initial amount: NaN
has only substance units: false
constant: false
is: SBO:0000252
type: Species
boundary condition: true
name: IDH1
is: O75874
initial concentration: NaN
is encoded by: hsa:3417

http://identifiers.org/biomodels.db/MODEL1310110042#_5b9537b4_a5be_4f1c_8896_bdd53774ddb3
initial amount: NaN
is: SBO:0000252
has only substance units: false
name: _LOC647190_1_c
constant: false
is encoded by: hsa:LOC647190
initial concentration: NaN
boundary condition: true
type: Species

metaM 3ivcoa m
is: http://identifiers.org/pubchem.compound/11966188
is: SBO:0000247
is: C05998
notes: FORMULA: C26H40N7O18P3S CHARGE: -4
initial amount: NaN
initial concentration: 1.0
is: HMDB06870
has only substance units: false
boundary condition: false
type: Species
constant: false
name: 3-hydroxyisovalerylcoa

metaM xyl D l
initial concentration: 1.0
initial amount: NaN
notes: FORMULA: C5H10O5 CHARGE: 0 INCHI: InChI=1S/C5H10O5/c6-1-3(8)5(10)4(9)2-7/h1,3-5,7-10H,2H2/t3-,4+,5+/m0/s1
is: CHEBI:15936
boundary condition: false
name: aldehydo-D-xylose
constant: false
has only substance units: false
type: Species
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110042#_a6dc5daf_1a2d_4e32_99a1_30f011f2de20
constant: false
name: ATP5G1
is: Q6FIH7
has only substance units: false
type: Species
initial amount: NaN
boundary condition: true
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:516

metaM ppi r
initial amount: NaN
notes: FORMULA: HO7P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00023 EHMN_ABBREVIATION: C00013
is: SBO:0000247
initial concentration: 1.0
boundary condition: false
constant: false
has only substance units: false
type: Species
name: Diphosphate
is: HMDB00250
is: CHEBI:33019
is: C00013

metaR C141CPT1
kinetic law: MODEL1310110042#
product: MODEL1310110042#
reactant: MODEL1310110042#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: production of tetradecenoylcarnitine
type: Reaction

metaM CE1944 c
has only substance units: false
notes: FORMULA: C4H8N CHARGE: 1 INCHI: InChI=1S/C4H7N/c1-2-4-5-3-1/h3H,1-2,4H2/p+1 EHMN_ABBREVIATION: CE1944
constant: false
boundary condition: false
initial amount: NaN
initial concentration: 1.0
type: Species
is: CHEBI:36781
is: SBO:0000247
name: 1-pyrrolinium

metaR FAOXC121C101m
kinetic law: MODEL1310110042#
product: MODEL1310110042#
reactant: MODEL1310110042#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C12:1-->C10:1)m
type: Reaction

metaR PSDm hs
notes: GENE_ASSOCIATION: (23761.1) SUBSYSTEM: Glycerophospholipid metabolism EC Number: 4.1.1.65 Confidence Level: 4 AUTHORS: PMID:15052331,PMID:9370338 NOTES:modified from TV version for hs NJ
name: Phosphatidylserine decarboxylase
product: MODEL1310110042#
kinetic law: MODEL1310110042#
is version of: http://identifiers.org/ec-code/4.1.1.65
type: Reaction
reactant: MODEL1310110042#
reversible: false
modifier: MODEL1310110042#
is: SBO:0000176
fast: false
is described by: ECO:0000269

metaR EX ach LPAREN e RPAREN
kinetic law: MODEL1310110042#
reactant: MODEL1310110042#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Acetylcholine exchange
type: Reaction

metaR FAOXC102C81x
kinetic law: MODEL1310110042#
product: MODEL1310110042#
reactant: MODEL1310110042#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C10:2-->C8:1)x
type: Reaction

metaR DIGALSIDEtl
kinetic law: MODEL1310110042#
name: digalside hs intracellular transport
product: MODEL1310110042#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 1 AUTHORS: NOTES:unknown mechanism for transport - however must get to other intracellular compartments (e.g. lysosome for degradation) NJ
reactant: MODEL1310110042#
is described by: ECO:0000000
fast: false
reversible: true
type: Reaction

metaM urcan c
is: HMDB00301
type: Species
name: Urocanate
initial concentration: 1.0
boundary condition: false
constant: false
is: C00785
is: SBO:0000247
is: CHEBI:17771
initial amount: NaN
has only substance units: false
notes: FORMULA: C6H5N2O2 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00534 EHMN_ABBREVIATION: C00785

metaR GLXO1
reactant: MODEL1310110042#
is version of: http://identifiers.org/ec-code/1.1.2.4
is: SBO:0000176
reversible: false
kinetic law: MODEL1310110042#
name: glyoxylate oxidase
fast: false
modifier: MODEL1310110042#
product: MODEL1310110042#
is version of: http://identifiers.org/ec-code/1.1.1.27
notes: GENE_ASSOCIATION: (3939.1) or (55293.1) or (3945.1 and 3939.1) or (197257.1) or (92483.1) or (3945.1) or (160287.1) or (3948.1) or (197257.2) or (3948.2) SUBSYSTEM: Glyoxylate and dicarboxylate metabolism EC Number: 1.2.3.5 Confidence Level: 4 AUTHORS: PMID:12768081,PMID:9038835,PMID:9604807,PMID:9783918 NOTES:NCD
is described by: ECO:0000269
type: Reaction

metaR r1459
reactant: MODEL1310110042#
reversible: true
type: Reaction
name: Transport reaction
is described by: ECO:0000000
product: MODEL1310110042#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: 1.3.1.27 Confidence Level: 0 AUTHORS: NOTES:
kinetic law: MODEL1310110042#
fast: false

http://identifiers.org/biomodels.db/MODEL1310110042#_94afbdbb_721c_4ec5_98e0_a8c6d8ac728f
boundary condition: true
is: P61457
constant: false
has only substance units: false
is: SBO:0000252
type: Species
name: PCBD1
initial concentration: NaN
is encoded by: hsa:5092
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110042#_6fdc4b3a_08d1_4761_96d5_362908f6d0a6
name: GAL3ST1
boundary condition: true
is encoded by: hsa:9514
has only substance units: false
initial amount: NaN
type: Species
is: Q99999
is: SBO:0000252
constant: false
initial concentration: NaN

metaR FAOXC164x
kinetic law: MODEL1310110042#
product: MODEL1310110042#
reactant: MODEL1310110042#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: isomerization(C16:4)x
type: Reaction

metaM tetdec2crn c
is: SBO:0000247
constant: false
type: Species
name: tetradecadienoyl carnitine
boundary condition: false
has only substance units: false
is: HMDB02014
initial concentration: 1.0
notes: FORMULA: C21H37NO4 CHARGE: 0
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110042#_a791485b_df79_4868_9062_8675bb5261ee
type: Species
initial amount: NaN
constant: false
is: SBO:0000252
is encoded by: hsa:55512
has only substance units: false
name: SMPD3
boundary condition: true
is: Q9NY59
initial concentration: NaN

metaM malt e
is: SBO:0000247
initial concentration: 1.0
is: C00208
notes: FORMULA: C12H22O11 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00194 EHMN_ABBREVIATION: C00208
constant: false
is: HMDB00163
boundary condition: false
initial amount: NaN
is: CHEBI:17306
name: Maltose
has only substance units: false
type: Species

metaM acetone c
boundary condition: false
type: Species
is: CHEBI:15347
name: acetone
notes: FORMULA: C3H6O CHARGE: 0 INCHI: InChI=1S/C3H6O/c1-3(2)4/h1-2H3 HEPATONET_1.0_ABBREVIATION: HC00193 EHMN_ABBREVIATION: C00207
initial concentration: 1.0
constant: false
is: SBO:0000247
is: HMDB01659
has only substance units: false
initial amount: NaN

metaR G6PDH1rer
notes: GENE_ASSOCIATION: (9563.1) SUBSYSTEM: Pentose phosphate pathway EC Number: 1.1.1.47 Confidence Level: 4 AUTHORS: PMID:10349511,PMID:12831846,PMID:2156506 NOTES:tv, jp NCD
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/1.1.1.47
reactant: MODEL1310110042#
kinetic law: MODEL1310110042#
reversible: true
modifier: MODEL1310110042#
product: MODEL1310110042#
type: Reaction
fast: false
is: SBO:0000176
name: glucose-6-phosphate dehydrogenase, endoplasmic reticulum

http://identifiers.org/biomodels.db/MODEL1310110042#_e5d65c66_edf6_46da_a42a_ae2a47091032
is: SBO:0000252
initial concentration: NaN
initial amount: NaN
constant: false
type: Species
is encoded by: hsa:3290
boundary condition: true
has only substance units: false
name: HSD11B1

http://identifiers.org/biomodels.db/MODEL1310110042#_a904944c_2a22_49eb_8960_47b1eb2fc8e8
constant: false
is: SBO:0000252
initial amount: NaN
has only substance units: false
type: Species
initial concentration: NaN
boundary condition: true
name: GNPDA2
is encoded by: hsa:132789
is: Q8TDQ7

metaM gly e
notes: FORMULA: C2H5NO2 CHARGE: 0
is: C00037
is: SBO:0000247
boundary condition: false
is: HMDB00123
initial amount: NaN
constant: false
is: CHEBI:3339
initial concentration: 1.0
type: Species
name: Glycine
has only substance units: false

metaR NDPK9n
notes: GENE_ASSOCIATION: (4831.1 and 4830.1) or (4830.2 and 4831.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.6 Confidence Level: 4 AUTHORS: NOTES:NCD
is described by: ECO:0000269
fast: false
type: Reaction
product: MODEL1310110042#
reactant: MODEL1310110042#
is: SBO:0000176
name: nucleoside-diphosphate kinase (ATP:IDP), nuclear
reversible: true
kinetic law: MODEL1310110042#
modifier: MODEL1310110042#
is version of: http://identifiers.org/ec-code/2.7.4.6

http://identifiers.org/biomodels.db/MODEL1310110042#_836c0876_39d7_4761_a4cb_cfaf6415a572
type: Species
is: P48448
is encoded by: hsa:222
constant: false
is: SBO:0000252
initial concentration: NaN
name: ALDH3B2
initial amount: NaN
has only substance units: false
boundary condition: true

metaR EX glc LPAREN e RPAREN
kinetic law: MODEL1310110042#
reactant: MODEL1310110042#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: D-Glucose exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110042#_b82464f0_403b_451f_83ee_796d6766aeac
name: _AV727634_1_c
initial concentration: NaN
type: Species
constant: false
boundary condition: true
is: SBO:0000252
is encoded by: hsa:AV727634
has only substance units: false
initial amount: NaN

metaR EX tethex3 LPAREN e RPAREN
kinetic law: MODEL1310110042#
reactant: MODEL1310110042#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: tetracosahexaenoic acid, n-3 exchange
type: Reaction

metaR PAIL4P HStn
is: SBO:0000185
kinetic law: MODEL1310110042#
product: MODEL1310110042#
name: phosphatidylinositol 4-phosphate nuclear transport (diffusion)
reactant: MODEL1310110042#
type: Reaction
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
fast: false

metaM lnlncgcrn m
is: SBO:0000247
constant: false
initial amount: NaN
has only substance units: false
type: Species
is: HMDB06318
name: gamma-linolenyl carnitine
initial concentration: 1.0
boundary condition: false
notes: FORMULA: C25H43NO4 CHARGE: 0 INCHI: InChI=1/C25H43NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-25(29)30-23(26(2,3)4)21-22-24(27)28/h9-10,12-13,15-16,23H,5-8,11,14,17-22H2,1-4H3/b10-9-,13-12-,16-15-/t23-/m0/s1

metaM ksi deg25 l
notes: FORMULA: C118H192N8O98S4 CHARGE: -4
name: keratan sulfate I, degradation product 25
constant: false
is: HMDB00812
initial concentration: 1.0
is: CHEBI:16953
has only substance units: false
boundary condition: false
type: Species
initial amount: NaN
is: SBO:0000247

metaR GLCt4
is: SBO:0000185
fast: false
reversible: true
kinetic law: MODEL1310110042#
is described by: ECO:0000269
modifier: MODEL1310110042#
product: MODEL1310110042#
name: glucose transport via sodium symport
reactant: MODEL1310110042#
type: Reaction
notes: GENE_ASSOCIATION: (200010.1) or (159963.1) or (6526.1) or (125206.1) or (6524.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:11133510,PMID:12436245,PMID:12748858,PMID:1372904,PMID:1415574,PMID:15546855,PMID:7537337,PMID:7789985,PMID:8282810 NOTES:NCD

metaM 3hdcoa c
constant: false
initial amount: NaN
name: (S)-3-Hydroxydecanoyl-CoA
type: Species
is: SBO:0000247
notes: FORMULA: C31H50N7O18P3S CHARGE: -4
initial concentration: 1.0
is: HMDB13325
has only substance units: false
boundary condition: false

metaR EX creat LPAREN e RPAREN
kinetic law: MODEL1310110042#
reactant: MODEL1310110042#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Creatine exchange
type: Reaction

metaR ADSK
is: SBO:0000176
modifier: MODEL1310110042#
name: adenylyl-sulfate kinase
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/2.7.1.25
reactant: MODEL1310110042#
kinetic law: MODEL1310110042#
fast: false
product: MODEL1310110042#
reversible: false
notes: GENE_ASSOCIATION: (9060.1) or (9061.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.1.25 Confidence Level: 4 AUTHORS: PMID:11931637,PMID:12716056 NOTES:
type: Reaction

metaR COQ6m
modifier: MODEL1310110042#
kinetic law: MODEL1310110042#
fast: false
product: MODEL1310110042#
reversible: false
is: SBO:0000176
notes: GENE_ASSOCIATION: (51004.1) or (51004.2) SUBSYSTEM: Ubiquinone synthesis EC Number: Confidence Level: 4 AUTHORS: PMID:11051212,PMID:1965190,PMID:7380842 NOTES:_1.13.12.- IT
type: Reaction
name: Ubiquinone biosynthesis monooxgenase COQ6
reactant: MODEL1310110042#
is described by: ECO:0000269

metaR GALASE16ly
fast: false
type: Reaction
is version of: http://identifiers.org/ec-code/3.4.16.5
reactant: MODEL1310110042#
product: MODEL1310110042#
is described by: ECO:0000000
kinetic law: MODEL1310110042#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.1.6.4
modifier: MODEL1310110042#
name: beta-galactosidase, lysosomal
reversible: false
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) or (5476.1) and (2720.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.23 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD
is version of: http://identifiers.org/ec-code/3.2.1.23
is version of: http://identifiers.org/ec-code/3.2.1.18

metaM ac m
is: HMDB00042
notes: FORMULA: C2H3O2 CHARGE: -1 INCHI: InChI=1S/C2H4O2/c1-2(3)4/h1H3,(H,3,4)/p-1 HEPATONET_1.0_ABBREVIATION: HC00042 EHMN_ABBREVIATION: C00033
has only substance units: false
type: Species
is: CHEBI:30089
initial amount: NaN
name: acetate
constant: false
boundary condition: false
is: SBO:0000247
initial concentration: 1.0

metaM 5HPET c
constant: false
boundary condition: false
initial amount: NaN
type: Species
is: HMDB01193
name: 5(S)-HPETE(1-)
is: CHEBI:57450
has only substance units: false
notes: FORMULA: C20H31O4 CHARGE: -1 INCHI: InChI=1S/C20H32O4/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-16-19(24-23)17-15-18-20(21)22/h6-7,9-10,12-14,16,19,23H,2-5,8,11,15,17-18H2,1H3,(H,21,22)/p-1/b7-6-,10-9-,13-12-,16-14+/t19-/m1/s1
is: SBO:0000247
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110042#_b1875039_73c5_4a2a_a109_f21750cc06bc
constant: false
has only substance units: false
is encoded by: hsa:115286
initial concentration: NaN
type: Species
initial amount: NaN
name: SLC25A26
boundary condition: true
is: SBO:0000252
is: Q70HW3

http://identifiers.org/biomodels.db/MODEL1310110042#_2babeba7_49e3_4a04_a284_36a3b7c77192
constant: false
initial amount: NaN
is: SBO:0000252
boundary condition: true
name: _AA576959_1_c
type: Species
has only substance units: false
initial concentration: NaN
is encoded by: hsa:AA576959

metaM h2o2 x
notes: FORMULA: H2O2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00036 EHMN_ABBREVIATION: C00027
is: SBO:0000247
is: CHEBI:16240
is: HMDB03125
initial concentration: 1.0
has only substance units: false
is: C00027
initial amount: NaN
boundary condition: false
name: Hydrogen peroxide
constant: false
type: Species

metaM accoa c
has only substance units: false
notes: FORMULA: C23H34N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00033 EHMN_ABBREVIATION: C00024
is: CHEBI:57288
initial amount: NaN
is: C00024
type: Species
is: SBO:0000247
name: Acetyl-CoA
is: HMDB01206
boundary condition: false
constant: false
initial concentration: 1.0

metaR DDCRNe
kinetic law: MODEL1310110042#
product: MODEL1310110042#
reactant: MODEL1310110042#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of 3-hydroxydodecanoyl carnitine into extra cellular space
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110042#_bea049bb_ab49_43b6_ae17_c0e988e14dd5
is: GO:0005777
is: SBO:0000290
constant: false
size: 1.0
spatial dimensions: 3.0
name: peroxisome
type: Compartment

metaR EX apnnox LPAREN e RPAREN
kinetic law: MODEL1310110042#
reactant: MODEL1310110042#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: alpha-Pinene-oxide exchange
type: Reaction

metaR EX ahdt LPAREN e RPAREN
kinetic law: MODEL1310110042#
reactant: MODEL1310110042#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of 7,8-dihydroneopterin 3-triphosphate(4-)
type: Reaction

metaM 3hodcoa c
type: Species
is: HMDB13336
initial amount: NaN
boundary condition: false
initial concentration: 1.0
notes: FORMULA: C39H66N7O18P3S CHARGE: -4
is: SBO:0000247
has only substance units: false
constant: false
name: (S)-3-Hydroxyoctadecanoyl-CoA

http://identifiers.org/biomodels.db/MODEL1310110042#_35f7f9b9_bc1c_4113_9869_f90666ca9f76
name: SULT2B1
type: Species
is encoded by: hsa:6820
constant: false
initial concentration: NaN
has only substance units: false
is: SBO:0000252
boundary condition: true
initial amount: NaN

metaM m5masnB2 g
initial concentration: 1.0
initial amount: NaN
type: Species
is: CHEBI:58401
constant: false
is: SBO:0000247
has only substance units: false
boundary condition: false
name: (alpha-D-mannosyl)5-beta-D-mannosyl-diacetylchitobiosyl-L-asparagine (protein)
notes: FORMULA: C52H87N2O40X CHARGE: 0
is: HMDB06814

http://identifiers.org/biomodels.db/MODEL1310110042#_d09b7532_0bef_411c_925c_09bda415c89f
boundary condition: true
type: Species
is: P06744
has only substance units: false
initial amount: NaN
is: SBO:0000252
is encoded by: hsa:2821
initial concentration: NaN
constant: false
name: GPI

http://identifiers.org/biomodels.db/MODEL1310110042#_da5422e8_0f54_446e_8081_558927ff3a10
is encoded by: hsa:D29675
initial amount: NaN
initial concentration: NaN
boundary condition: true
type: Species
is: SBO:0000252
constant: false
name: _D29675_1_c
has only substance units: false

metaR HIBDm
reversible: true
notes: GENE_ASSOCIATION: (11112.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 1.1.1.31 Confidence Level: 4 AUTHORS: PMID:7527207 NOTES:MM
fast: false
kinetic law: MODEL1310110042#
name: 3-hydroxyisobutyrate dehydrogenase, mitochondrial
modifier: MODEL1310110042#
product: MODEL1310110042#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.1.1.31
reactant: MODEL1310110042#
type: Reaction
is described by: ECO:0000269

metaM h2o g
has only substance units: false
name: water
boundary condition: false
is: SBO:0000247
constant: false
initial amount: NaN
is: HMDB02111
initial concentration: 1.0
is: CHEBI:15377
notes: FORMULA: H2O CHARGE: 0 INCHI: InChI=1S/H2O/h1H2 HEPATONET_1.0_ABBREVIATION: HC00011 EHMN_ABBREVIATION: C00001
type: Species

metaR ILETAm
modifier: MODEL1310110042#
is: SBO:0000176
fast: false
reversible: true
is described by: ECO:0000269
product: MODEL1310110042#
is version of: http://identifiers.org/ec-code/2.6.1.42
type: Reaction
reactant: MODEL1310110042#
notes: GENE_ASSOCIATION: (587.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 2.6.1.42 Confidence Level: 4 AUTHORS: PMID:6933702,PMID:9165094 NOTES:NCD
kinetic law: MODEL1310110042#
name: isoleucine transaminase, mitochondrial

http://identifiers.org/biomodels.db/MODEL1310110042#_a4ad10ea_fd6d_445e_89be_337c6f767b47
has only substance units: false
boundary condition: true
initial concentration: NaN
is: P32019
is encoded by: hsa:3633
initial amount: NaN
type: Species
name: INPP5B
is: SBO:0000252
constant: false

metaM xol7ah2 m
is: SBO:0000247
has only substance units: false
boundary condition: false
constant: false
name: 5beta-cholestane-3alpha,7alpha-diol
is: CHEBI:28047
notes: FORMULA: C27H48O2 CHARGE: 0 INCHI: InChI=1S/C27H48O2/c1-17(2)7-6-8-18(3)21-9-10-22-25-23(12-14-27(21,22)5)26(4)13-11-20(28)15-19(26)16-24(25)29/h17-25,28-29H,6-16H2,1-5H3/t18-,19+,20-,21-,22+,23+,24-,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01461 EHMN_ABBREVIATION: C05452
type: Species
is: HMDB06893
initial amount: NaN
initial concentration: 1.0

metaR r0932
reversible: true
type: Reaction
kinetic law: MODEL1310110042#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
fast: false
product: MODEL1310110042#
is described by: ECO:0000000
reactant: MODEL1310110042#
is: SBO:0000185
name: Transport reaction

metaR CBASPte
reversible: true
product: MODEL1310110042#
is described by: ECO:0000134
name: Transport of N-carbamoyl-L-aspartate
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
kinetic law: MODEL1310110042#
reactant: MODEL1310110042#
is: SBO:0000185
type: Reaction
fast: false

metaR GTHP
modifier: MODEL1310110042#
is described by: ECO:0000134
type: Reaction
kinetic law: MODEL1310110042#
name: glutathione peroxidase
product: MODEL1310110042#
reversible: true
is version of: http://identifiers.org/ec-code/1.11.1.15
is version of: http://identifiers.org/ec-code/1.11.1.12
reactant: MODEL1310110042#
notes: GENE_ASSOCIATION: (7001.3) or (5052.3) or (2877.1) or (2876.2) or (5052.2) or (2876.1) or (5052.1) or (7001.1) or (2879.1) or (7001.2) SUBSYSTEM: Glutathione metabolism EC Number: 1.11.1.9 Confidence Level: 4 AUTHORS: PMID:15802613,PMID:17015272,PMID:17015273 NOTES:NCD
is: SBO:0000176
fast: false
is version of: http://identifiers.org/ec-code/1.11.1.9

metaR C80CPT1
kinetic law: MODEL1310110042#
product: MODEL1310110042#
reactant: MODEL1310110042#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: production of octanoylcarnitine
type: Reaction

metaM ppbng c
is: HMDB00245
initial concentration: 1.0
notes: FORMULA: C10H13N2O4 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00588 EHMN_ABBREVIATION: C00931
constant: false
type: Species
initial amount: NaN
is: C00931
is: CHEBI:58126
name: Porphobilinogen
is: SBO:0000247
has only substance units: false
boundary condition: false

metaR AKR1D2
is described by: ECO:0000269
name: aldo-keto reductase family 1, member D1 (delta 4-3-ketosteroid-5-beta-reductase)
kinetic law: MODEL1310110042#
is version of: http://identifiers.org/ec-code/1.3.1.3
is: SBO:0000176
modifier: MODEL1310110042#
type: Reaction
reactant: MODEL1310110042#
fast: false
notes: GENE_ASSOCIATION: (6718.1) SUBSYSTEM: Bile acid synthesis EC Number: 1.3.99.6 Confidence Level: 4 AUTHORS: NOTES:refs: uniprot, KEGG DW Russell bile acid synthesis review paper (see human recon journal citations) NJ
reversible: false
product: MODEL1310110042#

metaR r1692
name: Y+LAT2 Utilized transport
reversible: false
fast: false
product: MODEL1310110042#
kinetic law: MODEL1310110042#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is: SBO:0000185
type: Reaction
reactant: MODEL1310110042#
modifier: MODEL1310110042#

metaR DOLDPP Ler
type: Reaction
modifier: MODEL1310110042#
is described by: ECO:0000000
reactant: MODEL1310110042#
is version of: http://identifiers.org/ec-code/3.6.1.43
kinetic law: MODEL1310110042#
product: MODEL1310110042#
is: SBO:0000176
name: Dolichyl-diphosphate phosphohydrolase, human (liver)
notes: GENE_ASSOCIATION: (57171.1) SUBSYSTEM: N-glycan synthesis EC Number: 3.6.1.43 Confidence Level: 0 AUTHORS: PMID:12137737 NOTES:NCD
reversible: false
fast: false

http://identifiers.org/biomodels.db/MODEL1310110042#_e5612e3b_8181_4339_8901_bd2e3d02c909
is encoded by: hsa:54872
is: Q8NCI4
has only substance units: false
initial amount: NaN
type: Species
initial concentration: NaN
constant: false
is: SBO:0000252
name: PIGG
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110042#_a6eeebdb_540d_48af_b0d6_90e2aef5613e
constant: false
type: Species
initial concentration: NaN
initial amount: NaN
is: Q5JRA6
is encoded by: hsa:375056
is: SBO:0000252
name: MIA3
boundary condition: true
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110042#_953235d6_9b98_4f1f_a6c8_b874a5ba69b4
is encoded by: hsa:T83654
name: _T83654_1_e
initial amount: NaN
is: SBO:0000252
type: Species
initial concentration: NaN
constant: false
has only substance units: false
boundary condition: true

metaM ribflv c
constant: false
name: Riboflavin
initial concentration: 1.0
has only substance units: false
type: Species
initial amount: NaN
is: SBO:0000247
notes: FORMULA: C17H20N4O6 CHARGE: 0
is: C00255
boundary condition: false
is: CHEBI:3554
is: HMDB00244

metaR EX C04849 LPAREN e RPAREN
kinetic law: MODEL1310110042#
reactant: MODEL1310110042#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: (5Z,9E,14Z)-(8xi,11R,12S)-11,12-epoxy-8-hydroxyicosa-5,9,14-trienoate exchange
type: Reaction

metaR APNNOXte
fast: false
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 1 AUTHORS: NOTES:unknown mechanism, xenobiotic transport (original and metabolized) NJ
is described by: ECO:0000000
kinetic law: MODEL1310110042#
name: xenobiotic transport
reactant: MODEL1310110042#
product: MODEL1310110042#
type: Reaction
is: SBO:0000185

metaR r0074
notes: GENE_ASSOCIATION: (84532.1) or (55902.1) SUBSYSTEM: Urea cycle EC Number: 1.5.1.12 Confidence Level: 0 AUTHORS: PMID:1286669,PMID:2211729 NOTES:
modifier: MODEL1310110042#
reversible: true
kinetic law: MODEL1310110042#
type: Reaction
is: SBO:0000176
fast: false
name: L-Glutamate 5-semialdehyde:NAD+ oxidoreductase Arginine and proline metabolism EC:1.5.1.12
product: MODEL1310110042#
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/6.2.1.1
reactant: MODEL1310110042#

metaM asp L m
has only substance units: false
is: HMDB00191
boundary condition: false
name: L-aspartate(1-)
type: Species
notes: FORMULA: C4H6NO4 CHARGE: -1 INCHI: InChI=1S/C4H7NO4/c5-2(4(8)9)1-3(6)7/h2H,1,5H2,(H,6,7)(H,8,9)/p-1/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00055
constant: false
initial concentration: 1.0
is: SBO:0000247
initial amount: NaN
is: CHEBI:29991

metaM ksi pre32 g
initial concentration: 1.0
initial amount: NaN
is: SBO:0000247
notes: FORMULA: C227H362N16O192S10X CHARGE: -11
type: Species
constant: false
boundary condition: false
name: keratan sulfate I biosynthesis, precursor 32
is: CHEBI:28067
has only substance units: false

metaR FAOXC102C81m
kinetic law: MODEL1310110042#
product: MODEL1310110042#
reactant: MODEL1310110042#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C10:2-->C8:1)m
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110042#_ae1d91f1_12e0_499f_832e_eab986efc5a2
is encoded by: hsa:85365
boundary condition: true
initial amount: NaN
has only substance units: false
is: SBO:0000252
type: Species
constant: false
is: Q9H553
name: ALG2
initial concentration: NaN

metaM 35cgmp n
boundary condition: false
is: CHEBI:57746
is: HMDB01314
initial amount: NaN
is: SBO:0000247
has only substance units: false
constant: false
initial concentration: 1.0
notes: FORMULA: C10H11N5O7P CHARGE: -1 INCHI: InChI=1S/C10H12N5O7P/c11-10-13-7-4(8(17)14-10)12-2-15(7)9-5(16)6-3(21-9)1-20-23(18,19)22-6/h2-3,5-6,9,16H,1H2,(H,18,19)(H3,11,13,14,17)/p-1/t3-,5-,6-,9-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00592 EHMN_ABBREVIATION: C00942
type: Species
name: 3',5'-cyclic GMP(1-)

http://identifiers.org/biomodels.db/MODEL1310110042#_41271ccf_ea4e_4252_be39_23227f53d44b
is: SBO:0000252
initial concentration: NaN
name: SLC25A26
type: Species
constant: false
has only substance units: false
initial amount: NaN
boundary condition: true
is encoded by: hsa:115286
is: F8WAB8

metaR 3HBCOAHLm
kinetic law: MODEL1310110042#
is: SBO:0000176
name: 3-hydroxyisobutyryl-CoA hydrolase, mitochondrial
is described by: ECO:0000000
product: MODEL1310110042#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 3.1.2.4 Confidence Level: 2 AUTHORS: PMID:8824301 NOTES:MM
type: Reaction
reactant: MODEL1310110042#
reversible: false

metaM stcrn m
has only substance units: false
is: SBO:0000247
notes: FORMULA: C25H49NO4 CHARGE: 0 INCHI: InChI=1/C25H49NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-25(29)30-23(21-24(27)28)22-26(2,3)4/h23H,5-22H2,1-4H3
initial concentration: 1.0
constant: false
is: HMDB00848
name: stearoylcarnitine
initial amount: NaN
type: Species
boundary condition: false

metaR C161OHc
kinetic law: MODEL1310110042#
product: MODEL1310110042#
reactant: MODEL1310110042#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: production of 3-hydroxyhexadecenoylcarnitine
type: Reaction

metaR GGH 5DHFe
modifier: MODEL1310110042#
is version of: http://identifiers.org/ec-code/3.4.19.9
notes: GENE_ASSOCIATION: (8836.1) SUBSYSTEM: Folate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:11375437,PMID:2867095,PMID:9614206 NOTES:REMOVES EITHER ONE OR TWO GLUTAMYL RESIDUES WITH A REACTION (WILL ONLY REPRESENT 1) - last step from 5-glutamyl to monoglutamyl is in one step IT
reversible: false
is: SBO:0000176
kinetic law: MODEL1310110042#
type: Reaction
is described by: ECO:0000000
reactant: MODEL1310110042#
product: MODEL1310110042#
fast: false
name: Gamma-glutamyl hydrolase (5DHF), extracellular

http://identifiers.org/biomodels.db/MODEL1310110042#_faf3a999_529f_4266_a037_5ca804351e25
constant: false
is: Q9HBH5
boundary condition: true
is encoded by: hsa:57665
name: RDH14
initial concentration: NaN
has only substance units: false
is: SBO:0000252
type: Species
initial amount: NaN

metaM din c
notes: FORMULA: C10H12N4O4 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC01493 EHMN_ABBREVIATION: C05512
is: HMDB00071
is: SBO:0000247
constant: false
type: Species
has only substance units: false
boundary condition: false
name: Deoxyinosine
is: C05512
is: CHEBI:28997
initial concentration: 1.0
initial amount: NaN

metaR GCCcm
modifier: MODEL1310110042#
reactant: MODEL1310110042#
fast: false
notes: GENE_ASSOCIATION: (275.1) and (1738.1) and (2731.1) and (2653.1) SUBSYSTEM: Glycine, serine, alanine and threonine metabolism EC Number: 2.1.2.10 Confidence Level: 4 AUTHORS: PMID:15355973 NOTES:NCD
reversible: true
product: MODEL1310110042#
is version of: http://identifiers.org/ec-code/2.1.2.10
kinetic law: MODEL1310110042#
is version of: http://identifiers.org/ec-code/1.8.1.4
is version of: http://identifiers.org/ec-code/1.4.4.2
is described by: ECO:0000269
is: SBO:0000176
name: glycine-cleavage complex (lipoylprotein), mitochondrial
type: Reaction

metaM glcur c
boundary condition: false
is: CHEBI:15748
initial concentration: 1.0
is: SBO:0000247
constant: false
is: HMDB00127
has only substance units: false
type: Species
name: D-glucuronate
initial amount: NaN
notes: FORMULA: C6H9O7 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00182 EHMN_ABBREVIATION: C00191

http://identifiers.org/biomodels.db/MODEL1310110042#_e2d18b73_22eb_43c2_8279_12d5c9b7c0ce
is: SBO:0000252
name: SLC26A7
boundary condition: true
initial concentration: NaN
constant: false
is encoded by: hsa:115111
has only substance units: false
initial amount: NaN
type: Species

http://identifiers.org/biomodels.db/MODEL1310110042#_cd7ddca0_24df_4017_96b7_4b8d4d8a7b45
is encoded by: hsa:6510
boundary condition: true
has only substance units: false
is: Q15758
is: SBO:0000252
name: SLC1A5
constant: false
initial concentration: NaN
initial amount: NaN
type: Species

metaR r0399
reversible: true
modifier: MODEL1310110042#
is: SBO:0000176
name: L-Phenylalanine,tetrahydrobiopterin:oxygen oxidoreductase (4-hydroxylating) Phenylalanine, tyrosine and tryptophan biosynthesis EC:1.14.16.1
product: MODEL1310110042#
reactant: MODEL1310110042#
is version of: http://identifiers.org/ec-code/1.2.4.2
kinetic law: MODEL1310110042#
fast: false
type: Reaction
notes: GENE_ASSOCIATION: (4967.1) or (55753.1) SUBSYSTEM: Tetrahydrobiopterin metabolism EC Number: 1.14.16.1 Confidence Level: 0 AUTHORS: PMID:3298976,PMID:4074362 NOTES:
is described by: ECO:0000000

metaM pail hs n
constant: false
name: 1-phosphatidyl-1D-myo-inositol(1-)
notes: FORMULA: C9H16O9PFULLRCO2FULLR2CO2 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC02009 EHMN_ABBREVIATION: C01194
initial amount: NaN
initial concentration: 1.0
type: Species
has only substance units: false
is: SBO:0000247
boundary condition: false
is: CHEBI:57880

metaM ddcacoa m
boundary condition: false
is: HMDB03571
has only substance units: false
is: CHEBI:57375
notes: FORMULA: C33H54N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00850 EHMN_ABBREVIATION: C01832
constant: false
type: Species
name: Dodecanoyl-CoA (n-C12:0CoA)
is: SBO:0000247
is: C01832
initial concentration: 1.0
initial amount: NaN

metaM pi x
boundary condition: false
type: Species
is: SBO:0000247
notes: FORMULA: HO4P CHARGE: -2 INCHI: InChI=1S/H3O4P/c1-5(2,3)4/h(H3,1,2,3,4)/p-2 HEPATONET_1.0_ABBREVIATION: HC00019 EHMN_ABBREVIATION: C00009
initial concentration: 1.0
has only substance units: false
initial amount: NaN
is: CHEBI:43474
name: hydrogenphosphate
is: HMDB00973
constant: false

metaR S6TASE2ly
is described by: ECO:0000000
reactant: MODEL1310110042#
reversible: true
name: N-acetylglucosamine-6-sulfatase, lysosomal
kinetic law: MODEL1310110042#
fast: false
is: SBO:0000176
product: MODEL1310110042#
modifier: MODEL1310110042#
type: Reaction
is version of: http://identifiers.org/ec-code/3.1.6.14
notes: GENE_ASSOCIATION: (2799.1) SUBSYSTEM: Heparan sulfate degradation EC Number: 3.1.6.14 Confidence Level: 4 AUTHORS: PMID:3196333,PMID:3689314,PMID:3689315 NOTES:NCD

metaR H2ETer
product: MODEL1310110042#
reactant: MODEL1310110042#
kinetic law: MODEL1310110042#
is described by: ECO:0000304
reversible: false
name: H2 phosphoethanolaminyl transferase, endoplasmic reticulum
modifier: MODEL1310110042#
type: Reaction
notes: GENE_ASSOCIATION: (23556.1) or (23556.2) SUBSYSTEM: Phosphatidylinositol phosphate metabolism EC Number: Confidence Level: 2 AUTHORS: PMID:10574991 NOTES:NCD
fast: false
is: SBO:0000176

metaR GTHO
reversible: false
is version of: http://identifiers.org/ec-code/1.8.1.7
type: Reaction
reactant: MODEL1310110042#
name: glutathione oxidoreductase
fast: false
kinetic law: MODEL1310110042#
is described by: ECO:0000254
notes: GENE_ASSOCIATION: (2936.1) SUBSYSTEM: Glutamate metabolism EC Number: 1.8.1.7 Confidence Level: 2 AUTHORS: PMID:10708558 NOTES:NCD, TV This EC (1.6.4.2) is obsolete. The new EC is 1.8.1.7. http://www.genome.ad.jp/dbget-bin/www_bget?ec:1.6.4.2
modifier: MODEL1310110042#
product: MODEL1310110042#
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110042#_34a46c7d_513f_4ba4_9336_bb9e5574411e
initial concentration: NaN
type: Species
constant: false
name: PEMT
is encoded by: hsa:10400
initial amount: NaN
boundary condition: true
has only substance units: false
is: Q9UBM1
is: SBO:0000252

metaM ribflv e
constant: false
is: CHEBI:3554
initial amount: NaN
boundary condition: false
notes: FORMULA: C17H20N4O6 CHARGE: 0
initial concentration: 1.0
type: Species
name: Riboflavin
is: C00255
has only substance units: false
is: SBO:0000247
is: HMDB00244

http://identifiers.org/biomodels.db/MODEL1310110042#_8114f2f7_2c58_4ae3_a99a_8d7031819132
is encoded by: hsa:23530
initial amount: NaN
boundary condition: true
initial concentration: NaN
type: Species
name: NNT
has only substance units: false
constant: false
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110042#_f456f942_2311_4b50_9878_274f431bb281
constant: false
initial concentration: NaN
has only substance units: false
is: Q38G75
boundary condition: true
is encoded by: hsa:2582
name: GALE
initial amount: NaN
is: SBO:0000252
type: Species

metaR r0173
fast: false
is version of: http://identifiers.org/ec-code/3.6.1.19
name: (S)-Lactate:NAD+ oxidoreductase Glycolysis / Gluconeogenesis / Pyruvate metabolism EC:1.1.1.27
type: Reaction
is: SBO:0000176
reactant: MODEL1310110042#
product: MODEL1310110042#
notes: GENE_ASSOCIATION: (3704.1) SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: 1.1.1.27 Confidence Level: 0 AUTHORS: PMID:12042361,PMID:17045662,PMID:7449128,PMID:9927705 NOTES:
is described by: ECO:0000000
reversible: true
kinetic law: MODEL1310110042#
modifier: MODEL1310110042#

metaM h2o2 m
is: C00027
notes: FORMULA: H2O2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00036 EHMN_ABBREVIATION: C00027
is: CHEBI:16240
is: SBO:0000247
has only substance units: false
boundary condition: false
name: Hydrogen peroxide
initial concentration: 1.0
constant: false
initial amount: NaN
type: Species
is: HMDB03125

metaR EX tsul LPAREN e RPAREN
kinetic law: MODEL1310110042#
reactant: MODEL1310110042#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Thiosulfate exchange
type: Reaction

metaM lnlncgcrn c
constant: false
name: gamma-linolenyl carnitine
type: Species
boundary condition: false
is: SBO:0000247
initial amount: NaN
initial concentration: 1.0
is: HMDB06318
notes: FORMULA: C25H43NO4 CHARGE: 0 INCHI: InChI=1/C25H43NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-25(29)30-23(26(2,3)4)21-22-24(27)28/h9-10,12-13,15-16,23H,5-8,11,14,17-22H2,1-4H3/b10-9-,13-12-,16-15-/t23-/m0/s1
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110042#_b9f71b5a_0cfa_4a9e_908c_312f551bdd8d
initial amount: NaN
name: CPOX
boundary condition: true
type: Species
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:1371
is: P36551
constant: false
has only substance units: false

metaM h2o c
initial amount: NaN
name: H2O
has only substance units: false
is: SBO:0000247
boundary condition: false
is: C00001
notes: FORMULA: H2O CHARGE: 0
is: HMDB02111
initial concentration: 1.0
constant: false
type: Species
is: CHEBI:3303

metaM m3mpdol U c
notes: FORMULA: C1425H2340N20O370P20 CHARGE: -20
has only substance units: false
type: Species
initial amount: NaN
name: (alpha-D-mannosyl)3-beta-D-mannosyl-diacetylchitodiphosphodolichol, human uterine homolog
boundary condition: false
is: SBO:0000247
is: CHEBI:37632
initial concentration: 1.0
constant: false

http://identifiers.org/biomodels.db/MODEL1310110042#_5971bacf_6e36_4b35_a657_4e81311672a3
initial amount: NaN
type: Species
name: ADH4
constant: false
has only substance units: false
initial concentration: NaN
boundary condition: true
is: P08319
is encoded by: hsa:127
is: SBO:0000252

metaR r0170
type: Reaction
notes: GENE_ASSOCIATION: (H77542.1) or (5313.1) or (5315.1) SUBSYSTEM: Cholesterol metabolism EC Number: 2.5.1.21 Confidence Level: 0 AUTHORS: PMID:11108725,PMID:1527001,PMID:17180682,PMID:7864626,PMID:8509416 NOTES:
is version of: http://identifiers.org/ec-code/2.7.1.40
is: SBO:0000176
reactant: MODEL1310110042#
product: MODEL1310110042#
kinetic law: MODEL1310110042#
name: Farnesyl-diphosphate:farnesyl-diphosphate farnesyltransferase Biosynthesis of steroids EC:2.5.1.21
is described by: ECO:0000000
modifier: MODEL1310110042#
fast: false
reversible: true

metaM HC01603 c
initial concentration: 1.0
is: C00234
notes: FORMULA: C20H21N7O7 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00212 EHMN_ABBREVIATION: C00234
boundary condition: false
type: Species
has only substance units: false
name: 10-Formyltetrahydrofolate
is: SBO:0000247
constant: false
is: CHEBI:57454
initial amount: NaN

metaM ametam c
has only substance units: false
notes: FORMULA: C14H24N6O3S CHARGE: 2 HEPATONET_1.0_ABBREVIATION: HC00683 EHMN_ABBREVIATION: C01137
is: HMDB00988
initial amount: NaN
is: C01137
constant: false
type: Species
is: CHEBI:57443
is: SBO:0000247
initial concentration: 1.0
name: S-Adenosylmethioninamine
boundary condition: false

metaM gullac c
boundary condition: false
is: SBO:0000247
initial amount: NaN
constant: false
is: CHEBI:17587
type: Species
is: HMDB03466
has only substance units: false
name: L-gulono-1,4-lactone
initial concentration: 1.0
notes: FORMULA: C6H10O6 CHARGE: 0 INCHI: InChI=1S/C6H10O6/c7-1-2(8)5-3(9)4(10)6(11)12-5/h2-5,7-10H,1H2/t2-,3+,4-,5+/m0/s1

metaM acetone m
is: CHEBI:15347
constant: false
notes: FORMULA: C3H6O CHARGE: 0 INCHI: InChI=1S/C3H6O/c1-3(2)4/h1-2H3 HEPATONET_1.0_ABBREVIATION: HC00193 EHMN_ABBREVIATION: C00207
initial concentration: 1.0
initial amount: NaN
boundary condition: false
is: SBO:0000247
has only substance units: false
name: acetone
is: HMDB01659
type: Species

metaM glcur e
has only substance units: false
notes: FORMULA: C6H9O7 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00182 EHMN_ABBREVIATION: C00191
name: D-glucuronate
is: HMDB00127
is: CHEBI:15748
initial amount: NaN
initial concentration: 1.0
type: Species
constant: false
is: SBO:0000247
boundary condition: false

metaM 4hbzcoa m
is: SBO:0000247
type: Species
constant: false
boundary condition: false
has only substance units: false
notes: FORMULA: C28H36N7O18P3S CHARGE: -4 INCHI: InChI=1/C28H40N7O18P3S/c1-28(2,22(39)25(40)31-8-7-18(37)30-9-10-57-27(41)15-3-5-16(36)6-4-15)12-50-56(47,48)53-55(45,46)49-11-17-21(52-54(42,43)44)20(38)26(51-17)35-14-34-19-23(29)32-13-33-24(19)35/h3-6,13-14,17,20-22,26,36,38-39H,7-12H2,1-2H3,(H,30,37)(H,31,40)(H,45,46)(H,47,48)(H2,29,32,33)(H2,42,43,44)/t17-,20?,21-,22+,26-/m1/s1
initial concentration: 1.0
initial amount: NaN
is: HMDB06467
name: 4-hydroxybenoyl-CoA

metaM h2o2 n
notes: FORMULA: H2O2 CHARGE: 0 INCHI: InChI=1S/H2O2/c1-2/h1-2H HEPATONET_1.0_ABBREVIATION: HC00036 EHMN_ABBREVIATION: C00027
boundary condition: false
initial concentration: 1.0
is: CHEBI:16240
name: hydrogen peroxide
is: SBO:0000247
is: HMDB03125
constant: false
has only substance units: false
initial amount: NaN
type: Species

metaR EX no LPAREN e RPAREN
kinetic law: MODEL1310110042#
reactant: MODEL1310110042#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for NO
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110042#_b72f9d22_316d_442e_b701_5b36121922cd
initial concentration: NaN
name: PPA2
initial amount: NaN
type: Species
is encoded by: hsa:27068
is: SBO:0000252
has only substance units: false
constant: false
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110042#_8a0c0981_4d08_4609_8d4b_b9167e074e95
is encoded by: hsa:51004
constant: false
is: B7Z3K8
initial amount: NaN
type: Species
has only substance units: false
initial concentration: NaN
name: COQ6
is: SBO:0000252
boundary condition: true

metaR r0719
fast: false
product: MODEL1310110042#
is: SBO:0000176
modifier: MODEL1310110042#
is version of: http://identifiers.org/ec-code/1.1.1.153
reversible: false
name: (S)-3-Hydroxytetradecanoyl-CoA:NAD+ oxidoreductase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:1.1.1.35 EC:1.1.1.211
is described by: ECO:0000000
type: Reaction
kinetic law: MODEL1310110042#
reactant: MODEL1310110042#
notes: GENE_ASSOCIATION: (6697.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.1.1.35 Confidence Level: 0 AUTHORS: PMID:10231530,PMID:10329704,PMID:1550553,PMID:1651711,PMID:7150615,PMID:8188243,PMID:8687463,PMID:9553139 NOTES:

metaR DLNLCGCPT2
type: Reaction
is described by: ECO:0000000
name: carnitine transferase
is version of: http://identifiers.org/ec-code/2.3.1.21
notes: GENE_ASSOCIATION: (1376.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: NOTES:NJ
kinetic law: MODEL1310110042#
reactant: MODEL1310110042#
fast: false
product: MODEL1310110042#
is: SBO:0000176
modifier: MODEL1310110042#
reversible: false

metaM pheacgln e
initial amount: NaN
notes: FORMULA: C13H16N2O4 CHARGE: 0 INCHI: InChI=1S/C13H16N2O4/c14-11(16)7-6-10(13(18)19)15-12(17)8-9-4-2-1-3-5-9/h1-5,10H,6-8H2,(H2,14,16)(H,15,17)(H,18,19)/p-1/t10-/m0/s1
has only substance units: false
is: CHEBI:58310
type: Species
is: HMDB06344
initial concentration: 1.0
name: (2S)-4-carbamoyl-2-(2-phenylacetamido)butanoate
constant: false
is: SBO:0000247
boundary condition: false

metaM 3hodcoa m
boundary condition: false
type: Species
has only substance units: false
is: SBO:0000247
initial concentration: 1.0
name: (S)-3-Hydroxyoctadecanoyl-CoA
notes: FORMULA: C39H66N7O18P3S CHARGE: -4
constant: false
is: http://identifiers.org/pubchem.compound/5280355
initial amount: NaN

metaM 3ivcoa c
is: HMDB06870
is: SBO:0000247
type: Species
constant: false
is: C05998
is: http://identifiers.org/pubchem.compound/11966188
notes: FORMULA: C26H40N7O18P3S CHARGE: -4
name: 3-hydroxyisovalerylcoa
initial amount: NaN
boundary condition: false
initial concentration: 1.0
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110042#_b2841e34_35fb_41d5_b674_1f191f660dff
is: SBO:0000252
initial amount: NaN
type: Species
is: P53602
constant: false
boundary condition: true
initial concentration: NaN
name: MVD
has only substance units: false
is encoded by: hsa:4597

metaR r1454
kinetic law: MODEL1310110042#
product: MODEL1310110042#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:17603022,PMID:6240978,PMID:7876265 NOTES:
is: SBO:0000185
name: TCDB:2.A.1.13.5 TCDB:2.A.1.13.1
reversible: false
reactant: MODEL1310110042#
fast: false
type: Reaction
is described by: ECO:0000000

metaM h2o e
is: SBO:0000247
is: C00001
is: HMDB02111
boundary condition: false
name: H2O
has only substance units: false
constant: false
is: CHEBI:15377
initial concentration: 1.0
notes: FORMULA: H2O CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00011 EHMN_ABBREVIATION: C00001
type: Species
initial amount: NaN

metaM 4hexdtricoa m
boundary condition: false
notes: FORMULA: C37H56N7O17P3S CHARGE: -4
initial amount: NaN
name: 4,7,10-hexadecatrienoylcoa
is: SBO:0000247
initial concentration: 1.0
constant: false
is: HMDB02288
has only substance units: false
type: Species

metaM ppi x
boundary condition: false
is: SBO:0000247
name: Diphosphate
has only substance units: false
is: CHEBI:33019
is: HMDB00250
notes: FORMULA: HO7P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00023 EHMN_ABBREVIATION: C00013
type: Species
initial amount: NaN
initial concentration: 1.0
constant: false
is: C00013

metaR FAOXC226C205m
kinetic law: MODEL1310110042#
product: MODEL1310110042#
reactant: MODEL1310110042#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C22:6-->C20:5)m
type: Reaction

metaR HOMt4
fast: false
notes: GENE_ASSOCIATION: (6541.1) or (84889.1) or (6542.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:11591158,PMID:11891586,PMID:12049641,PMID:1348489,PMID:14770310,PMID:7534987,PMID:8954799 NOTES:SAB
kinetic law: MODEL1310110042#
reactant: MODEL1310110042#
is: SBO:0000185
modifier: MODEL1310110042#
name: L-homoserine via sodium symport
is described by: ECO:0000269
reversible: false
product: MODEL1310110042#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110042#_0ebda5c7_9bfb_4485_a160_9c629ad3ad4a
is: SBO:0000252
type: Species
initial concentration: NaN
is encoded by: hsa:6547
constant: false
boundary condition: true
has only substance units: false
name: SLC8A3
initial amount: NaN

metaR G14T19g
is described by: ECO:0000000
reversible: false
notes: GENE_ASSOCIATION: (9334.1) or (8704.1) or (8703.1) or (8704.2) or (2683.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.38 Confidence Level: 4 AUTHORS: PMID:10747980,PMID:12512857,PMID:1903938,PMID:3094506,PMID:3144273,PMID:9405390,PMID:9435216 NOTES:Keratan sulfate II biosynthesis NCD
product: MODEL1310110042#
kinetic law: MODEL1310110042#
is version of: http://identifiers.org/ec-code/2.4.1.90
fast: false
reactant: MODEL1310110042#
is version of: http://identifiers.org/ec-code/2.4.1.22
type: Reaction
is: SBO:0000176
name: beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase, Golgi
modifier: MODEL1310110042#
is version of: http://identifiers.org/ec-code/2.4.1.38

http://identifiers.org/biomodels.db/MODEL1310110042#_382ce77d_a6bc_418a_8eff_578b331cf018
initial amount: NaN
type: Species
is: P00491
is: SBO:0000252
is encoded by: hsa:4860
has only substance units: false
initial concentration: NaN
name: PNP
constant: false
boundary condition: true

metaM HC01231 c
initial amount: NaN
is: SBO:0000247
is: CHEBI:58480
boundary condition: false
notes: FORMULA: C12H21N2O6S CHARGE: -1 INCHI: InChI=1S/C12H22N2O6S/c1-12(2,6-15)9(17)10(18)13-4-3-8(16)14-7(5-21)11(19)20/h7,9,15,17,21H,3-6H2,1-2H3,(H,13,18)(H,14,16)(H,19,20)/p-1/t7-,9-/m0/s1 EHMN_ABBREVIATION: C04079
initial concentration: 1.0
has only substance units: false
type: Species
constant: false
name: N-[(R)-pantothenoyl]-L-cysteinate

metaR EX 10fthf5glu LPAREN e RPAREN
kinetic law: MODEL1310110042#
reactant: MODEL1310110042#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 10-formyltetrahydrofolate-[Glu](5) exchange
type: Reaction

metaR r0394
product: MODEL1310110042#
kinetic law: MODEL1310110042#
type: Reaction
name: Xanthine:NAD+ oxidoreductase Purine metabolism EC:1.17.1.4
is: SBO:0000176
reversible: true
reactant: MODEL1310110042#
notes: GENE_ASSOCIATION: SUBSYSTEM: Nucleotide interconversion EC Number: 1.17.1.4 Confidence Level: 0 AUTHORS: PMID:2713424,PMID:8248161 NOTES:
fast: false
is described by: ECO:0000000

metaR DLNLCGCPT1
reversible: false
is version of: http://identifiers.org/ec-code/2.3.1.21
modifier: MODEL1310110042#
kinetic law: MODEL1310110042#
notes: GENE_ASSOCIATION: (1375.1) or (1375.3) or (1375.4) or (126129.1) or (1374.1) or (1375.2) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.21 Confidence Level: 4 AUTHORS: NOTES:NJ
name: carnitine O-palmitoyltransferase
is: SBO:0000176
reactant: MODEL1310110042#
is described by: ECO:0000000
product: MODEL1310110042#
type: Reaction
fast: false

http://identifiers.org/biomodels.db/MODEL1310110042#_438245ef_15f1_48d2_a2da_86645e4bccd8
is encoded by: hsa:AA081045
initial concentration: NaN
initial amount: NaN
has only substance units: false
type: Species
name: _AA081045_1_c
boundary condition: true
is: SBO:0000252
constant: false

metaM eicostetcrn c
initial amount: NaN
is: SBO:0000247
initial concentration: 1.0
notes: FORMULA: C27H45NO4 CHARGE: 0 INCHI: InChI=1/C27H46NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-27(31)32-25(23-26(29)30)24-28(2,3)4/h9-10,12-13,15-16,18-19,25H,5-8,11,14,17,20-24H2,1-4H3,(H,29,30)/q+1/p-1
constant: false
boundary condition: false
name: Eicosatetranoyl carnitine
is: HMDB01356
type: Species
is: CHEBI:57312
has only substance units: false

metaR r1453
product: MODEL1310110042#
name: L-proline:(acceptor) oxidoreductase Arginine and proline metabolism EC:1.5.99.8
type: Reaction
is described by: ECO:0000000
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: Confidence Level: 0 AUTHORS: PMID:18506409 NOTES:
reactant: MODEL1310110042#
fast: false
is: SBO:0000176
kinetic law: MODEL1310110042#

metaM caro c
notes: FORMULA: C40H56 CHARGE: 0 INCHI: InChI=1S/C40H56/c1-31(19-13-21-33(3)25-27-37-35(5)23-15-29-39(37,7)8)17-11-12-18-32(2)20-14-22-34(4)26-28-38-36(6)24-16-30-40(38,9)10/h11-14,17-22,25-28H,15-16,23-24,29-30H2,1-10H3/b12-11+,19-13+,20-14+,27-25+,28-26+,31-17+,32-18+,33-21+,34-22+ EHMN_ABBREVIATION: C02094
has only substance units: false
initial amount: NaN
type: Species
initial concentration: 1.0
is: HMDB00561
constant: false
is: SBO:0000247
boundary condition: false
name: beta-carotene
is: CHEBI:17579

http://identifiers.org/biomodels.db/MODEL1310110042#_1453c8b6_c13c_45a8_a95d_a5103dcf62c4
initial amount: NaN
is: SBO:0000252
boundary condition: true
is: D3DX95
constant: false
has only substance units: false
type: Species
initial concentration: NaN
name: CHAT
is encoded by: hsa:1103

metaM dcmp n
has only substance units: false
initial concentration: 1.0
constant: false
initial amount: NaN
name: dCMP(2-)
notes: FORMULA: C9H12N3O7P CHARGE: -2 INCHI: InChI=1S/C9H14N3O7P/c10-7-1-2-12(9(14)11-7)8-3-5(13)6(19-8)4-18-20(15,16)17/h1-2,5-6,8,13H,3-4H2,(H2,10,11,14)(H2,15,16,17)/p-2/t5-,6+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00217 EHMN_ABBREVIATION: C00239
boundary condition: false
is: SBO:0000247
is: CHEBI:57566
is: HMDB01202
type: Species

metaM 3tetd7ecoa c
constant: false
type: Species
is: HMDB05066
initial amount: NaN
name: 3-hydroxy tetradecenoyl-7-coa
has only substance units: false
initial concentration: 1.0
is: SBO:0000247
boundary condition: false
notes: FORMULA: C35H56N7O18P3S CHARGE: -4

metaM crn c
type: Species
is: HMDB00062
notes: FORMULA: C7H15NO3 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00270 EHMN_ABBREVIATION: C00318
name: L-Carnitine
is: CHEBI:16347
is: SBO:0000247
is: C00318
constant: false
initial amount: NaN
initial concentration: 1.0
has only substance units: false
boundary condition: false

metaR TDPm
fast: false
reversible: false
product: MODEL1310110042#
is described by: ECO:0000000
name: thiamin pyrophosphatase, mitochondrial
kinetic law: MODEL1310110042#
is: SBO:0000176
type: Reaction
reactant: MODEL1310110042#
notes: GENE_ASSOCIATION: SUBSYSTEM: Thiamine metabolism EC Number: 3.6.1.15 Confidence Level: 2 AUTHORS: PMID:9755848 NOTES:_01-25-05 IT

metaR r0395
is described by: ECO:0000000
reactant: MODEL1310110042#
type: Reaction
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Nucleotide interconversion EC Number: 1.17.3.2 Confidence Level: 0 AUTHORS: PMID:11993848,PMID:1643670,PMID:3010873,PMID:8343533 NOTES:
is: SBO:0000176
name: Hypoxanthine:oxygen oxidoreductase Purine metabolism EC:1.17.3.2
reversible: true
product: MODEL1310110042#
kinetic law: MODEL1310110042#

metaR FTCD
kinetic law: MODEL1310110042#
modifier: MODEL1310110042#
reactant: MODEL1310110042#
is: SBO:0000176
fast: false
type: Reaction
product: MODEL1310110042#
is described by: ECO:0000134
reversible: false
name: formimidoyltransferase cyclodeaminase
is version of: http://identifiers.org/ec-code/2.1.2.5
notes: GENE_ASSOCIATION: (10841.1) or (10841.2) SUBSYSTEM: Folate metabolism EC Number: 4.3.1.4 Confidence Level: 4 AUTHORS: PMID:14697341 NOTES:IT

metaR DESAT16 2
is described by: ECO:0000000
fast: false
modifier: MODEL1310110042#
notes: GENE_ASSOCIATION: (6319.1) SUBSYSTEM: Fatty acid synthesis EC Number: 1.14.19.1 Confidence Level: 4 AUTHORS: PMID:14967823 NOTES:for homo sapiens, noted to actually be NADH-cyt b5, using NADH at present NJ
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.14.19.1
reversible: false
product: MODEL1310110042#
kinetic law: MODEL1310110042#
type: Reaction
name: palmitoyl-CoA desaturase (n-C16:0CoA -> n-C16:1CoA)
reactant: MODEL1310110042#

http://identifiers.org/biomodels.db/MODEL1310110042#_3dcdf40a_03a2_4e6b_851d_206f880c6c4b
is: P05177
name: CYP1A2
boundary condition: true
constant: false
is encoded by: hsa:1544
is: SBO:0000252
has only substance units: false
initial amount: NaN
type: Species
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110042#_dee3c6ad_6da0_4f80_a628_12e503b0e85e
type: Species
boundary condition: true
initial concentration: NaN
is encoded by: hsa:5151
name: PDE8A
constant: false
is: SBO:0000252
has only substance units: false
initial amount: NaN

metaM ksi deg36 l
name: keratan sulfate I, degradation product 36
initial concentration: 1.0
has only substance units: false
is: SBO:0000247
boundary condition: false
constant: false
is: CHEBI:12936
is: HMDB00143
type: Species
initial amount: NaN
notes: FORMULA: C62H103N4O49S1 CHARGE: -1

metaR DHCHOLESTANATEtm
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: PMID:12840657 NOTES:cholesterol precursor, transport by "diffusion" -> actually beleived to be flip-flop mechanism (PMID: 12840657). NJ
reversible: true
product: MODEL1310110042#
reactant: MODEL1310110042#
name: lipid, flip-flop intracellular transport
is: SBO:0000185
type: Reaction
kinetic law: MODEL1310110042#
fast: false
is described by: ECO:0000000

metaR r0931
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
product: MODEL1310110042#
reactant: MODEL1310110042#
fast: false
name: Transport reaction
type: Reaction
kinetic law: MODEL1310110042#
reversible: false
is: SBO:0000185
is described by: ECO:0000000

metaR RE3002X
product: MODEL1310110042#
fast: false
reactant: MODEL1310110042#
notes: GENE_ASSOCIATION: (10455.1) or (1962.1) SUBSYSTEM: Fatty acid oxidation EC Number: 5.3.3.8 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:7775433 NOTES:
is version of: http://identifiers.org/ec-code/1.1.1.35
is: SBO:0000176
reversible: true
type: Reaction
modifier: MODEL1310110042#
kinetic law: MODEL1310110042#
is version of: http://identifiers.org/ec-code/5.3.3.8
name: RE3002
is described by: ECO:0000000

metaM decdicrn c
name: decadienoyl carnitine
constant: false
is: SBO:0000247
notes: FORMULA: C17H29NO4 CHARGE: 0
is: HMDB13325
has only substance units: false
initial amount: NaN
boundary condition: false
initial concentration: 1.0
type: Species

metaM pheacgln c
constant: false
is: SBO:0000247
notes: FORMULA: C13H16N2O4 CHARGE: 0 INCHI: InChI=1S/C13H16N2O4/c14-11(16)7-6-10(13(18)19)15-12(17)8-9-4-2-1-3-5-9/h1-5,10H,6-8H2,(H2,14,16)(H,15,17)(H,18,19)/p-1/t10-/m0/s1
has only substance units: false
initial amount: NaN
is: CHEBI:58310
name: (2S)-4-carbamoyl-2-(2-phenylacetamido)butanoate
type: Species
initial concentration: 1.0
is: HMDB06344
boundary condition: false

metaM decdicrn e
boundary condition: false
name: decadienoyl carnitine
is: SBO:0000247
initial concentration: 1.0
has only substance units: false
is: HMDB13325
type: Species
notes: FORMULA: C17H29NO4 CHARGE: 0
constant: false
initial amount: NaN

metaM ac c
notes: FORMULA: C2H3O2 CHARGE: -1 INCHI: InChI=1S/C2H4O2/c1-2(3)4/h1H3,(H,3,4)/p-1 HEPATONET_1.0_ABBREVIATION: HC00042 EHMN_ABBREVIATION: C00033
initial amount: NaN
has only substance units: false
is: HMDB00042
type: Species
is: CHEBI:30089
initial concentration: 1.0
constant: false
boundary condition: false
name: acetate
is: SBO:0000247

metaR M16N4Tg
reactant: MODEL1310110042#
kinetic law: MODEL1310110042#
product: MODEL1310110042#
name: alpha-1,6-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase
is: SBO:0000176
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: N-glycan synthesis EC Number: 2.4.1.201 Confidence Level: 0 AUTHORS: NOTES:NCD
is described by: ECO:0000000
reversible: false
type: Reaction

metaR GTHOm
name: glutathione oxidoreductase
fast: false
is described by: ECO:0000254
notes: GENE_ASSOCIATION: (2936.1) SUBSYSTEM: Glutamate metabolism EC Number: 1.8.1.7 Confidence Level: 2 AUTHORS: PMID:10708558,PMID:15149466 NOTES:NCD, TV This EC (1.6.4.2) is obsolete. The new EC is 1.8.1.7. http://www.genome.ad.jp/dbget-bin/www_bget?ec:1.6.4.2
type: Reaction
reactant: MODEL1310110042#
kinetic law: MODEL1310110042#
is: SBO:0000176
modifier: MODEL1310110042#
reversible: false
is version of: http://identifiers.org/ec-code/1.8.1.7
product: MODEL1310110042#

metaM CE5236 c
is: CHEBI:28002
name: O2'-4a-cyclic-tetrahydrobiopterin
constant: false
is: HMDB03952
type: Species
notes: FORMULA: C9H13N5O3 CHARGE: 0 INCHI: InChI=1/C9H13N5O3/c1-3-5(15)4-2-11-6-9(14-4,17-3)7(16)13-8(10)12-6/h3-5,14-15H,2H2,1H3,(H3,10,11,12,13,16)/p+1/t3-,4u,5+,9u/m0/s1 EHMN_ABBREVIATION: CE5236
is: SBO:0000247
initial amount: NaN
initial concentration: 1.0
has only substance units: false
boundary condition: false

metaM didp c
is: CHEBI:28823
notes: FORMULA: C10H11N4O10P2 CHARGE: -3 INCHI: InChI=1S/C10H14N4O10P2/c15-5-1-7(14-4-13-8-9(14)11-3-12-10(8)16)23-6(5)2-22-26(20,21)24-25(17,18)19/h3-7,15H,1-2H2,(H,20,21)(H,11,12,16)(H2,17,18,19)/t5-,6+,7+/m0/s1 EHMN_ABBREVIATION: C01344
is: HMDB03536
name: dIDP
initial amount: NaN
type: Species
has only substance units: false
initial concentration: 1.0
constant: false
boundary condition: false
is: SBO:0000247

metaR r0393
reactant: MODEL1310110042#
notes: GENE_ASSOCIATION: (1633.1) SUBSYSTEM: Unassigned EC Number: 1.2.1.3 Confidence Level: 0 AUTHORS: PMID:12705826,PMID:170276,PMID:6189823,PMID:6285247,PMID:8155713 NOTES:
type: Reaction
product: MODEL1310110042#
fast: false
is: SBO:0000176
kinetic law: MODEL1310110042#
reversible: false
modifier: MODEL1310110042#
name: D-Glyceraldehyde:NAD+ oxidoreductase Glycerolipid metabolism EC:1.2.1.3
is version of: http://identifiers.org/ec-code/2.7.1.74
is described by: ECO:0000000

metaR r0715
is: SBO:0000176
reversible: false
product: MODEL1310110042#
reactant: MODEL1310110042#
kinetic law: MODEL1310110042#
notes: GENE_ASSOCIATION: (AI435857.1) or (79717.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.1.1.35 Confidence Level: 0 AUTHORS: PMID:10231530,PMID:10329704,PMID:1550553,PMID:1651711,PMID:7150615,PMID:8188243,PMID:8687463,PMID:9553139 NOTES:
is described by: ECO:0000000
fast: false
type: Reaction
modifier: MODEL1310110042#
is version of: http://identifiers.org/ec-code/6.3.2.5
name: (S)-3-Hydroxyhexadecanoyl-CoA:NAD+ oxidoreductase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:1.1.1.35 EC:1.1.1.211

metaM 3octdeccrn c
name: 3-hydroxyoctadecanoyl carnitine
is: SBO:0000247
type: Species
initial amount: NaN
has only substance units: false
notes: FORMULA: C25H49NO5 CHARGE: 0
initial concentration: 1.0
boundary condition: false
constant: false
is: HMDB13336

http://identifiers.org/biomodels.db/MODEL1310110042#_bc7e5c89_73a1_418c_9cf6_9698e73a988c
is encoded by: hsa:79751
is: SBO:0000252
boundary condition: true
initial amount: NaN
is: Q9H936
has only substance units: false
name: SLC25A22
constant: false
initial concentration: NaN
type: Species

metaM pi r
notes: FORMULA: HO4P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00019 EHMN_ABBREVIATION: C00009
is: SBO:0000247
is: C00009
is: HMDB00973
type: Species
initial amount: NaN
is: CHEBI:43474
boundary condition: false
initial concentration: 1.0
has only substance units: false
name: hydrogenphosphate
constant: false

metaM crn e
notes: FORMULA: C7H15NO3 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00270 EHMN_ABBREVIATION: C00318
initial amount: NaN
initial concentration: 1.0
is: C00318
constant: false
is: SBO:0000247
is: HMDB00062
boundary condition: false
name: L-Carnitine
is: CHEBI:16347
has only substance units: false
type: Species

metaR CITt4 4
reactant: MODEL1310110042#
product: MODEL1310110042#
kinetic law: MODEL1310110042#
name: citrate transport via sodium symport
is described by: ECO:0000006
modifier: MODEL1310110042#
reversible: true
fast: false
is: SBO:0000185
notes: GENE_ASSOCIATION: (284111.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12177002,PMID:12445824 NOTES:NCD
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110042#_16bc5394_c1e1_4dcd_9115_0f75f0e4377f
constant: false
has only substance units: false
type: Species
is: P27144
boundary condition: true
is encoded by: hsa:205
name: AK4
is: SBO:0000252
initial concentration: NaN
initial amount: NaN

metaR EX c101crn
kinetic law: MODEL1310110042#
reactant: MODEL1310110042#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for decenoyl carnitine
type: Reaction

metaR FAOXC8C6m
kinetic law: MODEL1310110042#
product: MODEL1310110042#
reactant: MODEL1310110042#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C8-->C6)m
type: Reaction

metaM cs a l
is: SBO:0000247
initial concentration: 1.0
name: chondroitin sulfate A (GalNAc4S-GlcA), free chain
constant: false
boundary condition: false
notes: FORMULA: C45H67N2O46S3 CHARGE: -5
has only substance units: false
is: CHEBI:36005
is: HMDB02183
type: Species
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110042#_f9ef31f8_f1fa_48ab_bcd6_c2a8a26ec349
initial amount: NaN
is: SBO:0000252
is encoded by: hsa:5277
boundary condition: true
constant: false
type: Species
has only substance units: false
initial concentration: NaN
name: PIGA

metaM cmpacna c
initial concentration: 1.0
is: CHEBI:57812
boundary condition: false
name: CMP-N-acetyl-beta-neuraminate(2-)
notes: FORMULA: C20H29N4O16P CHARGE: -2 INCHI: InChI=1S/C20H31N4O16P/c1-7(26)22-12-8(27)4-20(18(32)33,39-16(12)13(29)9(28)5-25)40-41(35,36)37-6-10-14(30)15(31)17(38-10)24-3-2-11(21)23-19(24)34/h2-3,8-10,12-17,25,27-31H,4-6H2,1H3,(H,22,26)(H,32,33)(H,35,36)(H2,21,23,34)/p-2/t8-,9+,10+,12+,13+,14+,15+,16+,17+,20+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00126 EHMN_ABBREVIATION: C00128
initial amount: NaN
is: HMDB01176
type: Species
constant: false
has only substance units: false
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110042#_156a49e8_252e_4eb2_8660_6c21e01a1a4a
constant: false
type: Species
initial concentration: NaN
initial amount: NaN
is: SBO:0000252
is encoded by: hsa:79623
has only substance units: false
boundary condition: true
name: GALNT14
is: Q96FL9

metaR 5MTHFt2le
kinetic law: MODEL1310110042#
reversible: true
type: Reaction
is described by: ECO:0000134
is: SBO:0000185
reactant: MODEL1310110042#
name: 5-methyltetrahydrofolate transport via anion exchange
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
product: MODEL1310110042#
fast: false

metaR r0714
fast: false
is: SBO:0000176
reversible: false
name: (S)-3-Hydroxyhexadecanoyl-CoA:NAD+ oxidoreductase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:1.1.1.211 EC:1.1.1.35
product: MODEL1310110042#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: 1.1.1.35 Confidence Level: 0 AUTHORS: PMID:10231530,PMID:10329704,PMID:1550553,PMID:1651711,PMID:7150615,PMID:8188243,PMID:8687463,PMID:9553139 NOTES:
type: Reaction
kinetic law: MODEL1310110042#
reactant: MODEL1310110042#

metaM met L c
notes: FORMULA: C5H11NO2S CHARGE: 0 INCHI: InChI=1S/C5H11NO2S/c1-9-3-2-4(6)5(7)8/h4H,2-3,6H2,1H3,(H,7,8)/t4-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00075
constant: false
is: SBO:0000247
name: L-methionine
is: HMDB00696
type: Species
initial amount: NaN
initial concentration: 1.0
is: CHEBI:16643
boundary condition: false
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110042#_80f103d9_fdc9_4952_ac36_0c34deabdd1f
is: P24666
type: Species
initial concentration: NaN
initial amount: NaN
boundary condition: true
has only substance units: false
is: SBO:0000252
constant: false
is encoded by: hsa:52
name: ACP1

metaR r0392
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 1.2.1.3 Confidence Level: 0 AUTHORS: PMID:12705826,PMID:170276,PMID:6189823,PMID:6285247,PMID:8155713 NOTES:
kinetic law: MODEL1310110042#
fast: false
is: SBO:0000176
product: MODEL1310110042#
name: D-Glyceraldehyde:NAD+ oxidoreductase Glycerolipid metabolism EC:1.2.1.3
reversible: true
is described by: ECO:0000000
reactant: MODEL1310110042#

metaR G14T18g
is version of: http://identifiers.org/ec-code/2.4.1.22
kinetic law: MODEL1310110042#
is version of: http://identifiers.org/ec-code/2.4.1.38
is version of: http://identifiers.org/ec-code/2.4.1.90
reactant: MODEL1310110042#
notes: GENE_ASSOCIATION: (8703.1) or (8704.2) or (8704.1) or (2683.1) or (9334.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.38 Confidence Level: 4 AUTHORS: PMID:10747980,PMID:12512857,PMID:1903938,PMID:3094506,PMID:3144273,PMID:9405390,PMID:9435216 NOTES:Keratan sulfate II biosynthesis NCD
type: Reaction
is: SBO:0000176
product: MODEL1310110042#
modifier: MODEL1310110042#
name: beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase, Golgi
is described by: ECO:0000000
reversible: false
fast: false

metaM hs deg22 l
is: SBO:0000247
initial concentration: 1.0
boundary condition: false
type: Species
is: CHEBI:21338
has only substance units: false
is: HMDB02704
initial amount: NaN
notes: FORMULA: C37H56NO35S CHARGE: -3
constant: false
name: IdoA-beta-1,4-GlcNAc(3S)-alpha-1,4-GlcA-beta-1,3-Gal-beta-1,3-Gal-beta-1,4-Xylose

metaM sprm c
initial concentration: 1.0
is: HMDB01256
name: spermine(4+)
type: Species
boundary condition: false
constant: false
notes: FORMULA: C10H30N4 CHARGE: 4 INCHI: InChI=1S/C10H26N4/c11-5-3-9-13-7-1-2-8-14-10-4-6-12/h13-14H,1-12H2 HEPATONET_1.0_ABBREVIATION: HC00525 EHMN_ABBREVIATION: C00750
initial amount: NaN
is: SBO:0000247
has only substance units: false
is: CHEBI:45725

http://identifiers.org/biomodels.db/MODEL1310110042#_a9c9e14f_02a4_4142_be4f_187f7797910b
name: SLC28A2
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:9153
is: SBO:0000252
has only substance units: false
type: Species
is: O43868
constant: false
boundary condition: true

metaR THRGLNexR
is described by: ECO:0000304
product: MODEL1310110042#
is: SBO:0000185
kinetic law: MODEL1310110042#
fast: false
name: L-threonine/glycine reversible exchange
reversible: true
reactant: MODEL1310110042#
modifier: MODEL1310110042#
type: Reaction
notes: GENE_ASSOCIATION: (56301.1) and (6520.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10734121,PMID:10863037,PMID:14770310 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110042#_f1ae4fee_fe00_4599_84cd_e9342e5c77e7
is: Q6IB54
is encoded by: hsa:522
initial concentration: NaN
type: Species
name: ATP5J
constant: false
initial amount: NaN
has only substance units: false
boundary condition: true
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110042#_0bd4ebf2_5886_4bb3_aa5a_9d0b29109f31
name: UCK1
is: Q5JT09
has only substance units: false
constant: false
boundary condition: true
type: Species
initial concentration: NaN
is encoded by: hsa:83549
is: SBO:0000252
initial amount: NaN

metaM clpn hs c
initial concentration: 1.0
constant: false
is: SBO:0000247
notes: FORMULA: C9H16O9P2FULLRCO2FULLR2CO2FULLRCO2FULLR2CO2 CHARGE: -2
name: cardiolipin
is: CHEBI:28494
boundary condition: false
type: Species
has only substance units: false
initial amount: NaN

metaR FAOXC221C201x
kinetic law: MODEL1310110042#
product: MODEL1310110042#
reactant: MODEL1310110042#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C22:1-->C20:1)x
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110042#_0c972037_3aee_4be8_87f4_44227642c142
is: P31939
constant: false
type: Species
is encoded by: hsa:471
boundary condition: true
initial concentration: NaN
initial amount: NaN
has only substance units: false
is: SBO:0000252
name: ATIC

metaR FAOXC14C12m
kinetic law: MODEL1310110042#
product: MODEL1310110042#
reactant: MODEL1310110042#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C14-->C12)m
type: Reaction

metaM h2o r
name: H2O
is: SBO:0000247
type: Species
is: C00001
is: CHEBI:15377
initial amount: NaN
is: HMDB02111
boundary condition: false
initial concentration: 1.0
has only substance units: false
constant: false
notes: FORMULA: H2O CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00011 EHMN_ABBREVIATION: C00001

metaR r0717
reversible: false
name: (S)-3-Hydroxyhexadecanoyl-CoA hydro-lyase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:4.2.1.17
is: SBO:0000176
fast: false
kinetic law: MODEL1310110042#
product: MODEL1310110042#
is described by: ECO:0000000
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.17 Confidence Level: 0 AUTHORS: PMID:8012501,PMID:8188243 NOTES:
reactant: MODEL1310110042#

metaR FAOXC121x
kinetic law: MODEL1310110042#
product: MODEL1310110042#
reactant: MODEL1310110042#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: isomerization(C12:1)x
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110042#_75134f52_7ad8_4cb2_8bad_cee1dffa231a
name: ADH5
has only substance units: false
boundary condition: true
constant: false
initial amount: NaN
is: SBO:0000252
is: Q6IRT1
type: Species
initial concentration: NaN
is encoded by: hsa:128

http://identifiers.org/biomodels.db/MODEL1310110042#_59aebc61_c7c2_4366_bd7e_c661acdd747f
is: SBO:0000252
type: Species
initial amount: NaN
name: ACP2
has only substance units: false
constant: false
initial concentration: NaN
is encoded by: hsa:53
is: E9PCI1
boundary condition: true

metaM 3octdeccrn e
initial amount: NaN
name: 3-hydroxyoctadecanoyl carnitine
type: Species
notes: FORMULA: C25H49NO5 CHARGE: 0
has only substance units: false
constant: false
is: HMDB13336
initial concentration: 1.0
boundary condition: false
is: SBO:0000247

metaR ARGtm
name: arginine mitochondrial transport via ornithine carrier
product: MODEL1310110042#
type: Reaction
reversible: true
fast: false
is: SBO:0000185
modifier: MODEL1310110042#
notes: GENE_ASSOCIATION: (83884.1) or (10166.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172 NOTES:TDV
is described by: ECO:0000269
kinetic law: MODEL1310110042#
reactant: MODEL1310110042#

http://identifiers.org/biomodels.db/MODEL1310110042#_5d752933_d5e1_48c0_aa62_0ad20dda836f
is: P51648
is encoded by: hsa:224
constant: false
has only substance units: false
initial concentration: NaN
type: Species
initial amount: NaN
boundary condition: true
is: SBO:0000252
name: ALDH3A2

metaR GTMLTe
reversible: false
name: g-glutamyltransferase (e)
is version of: http://identifiers.org/ec-code/2.3.2.2
product: MODEL1310110042#
fast: false
is: SBO:0000185
reactant: MODEL1310110042#
kinetic law: MODEL1310110042#
modifier: MODEL1310110042#
type: Reaction
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (2679.1) or (2678.1) or (2678.3) or (2678.2) SUBSYSTEM: Glutathione metabolism EC Number: 2.3.2.2 Confidence Level: 4 AUTHORS: PMID:15469854 NOTES:NCD SAB e see Disussion section of PMID 15469854

metaM stcrn c
boundary condition: false
is: HMDB00848
type: Species
has only substance units: false
is: SBO:0000247
notes: FORMULA: C25H49NO4 CHARGE: 0 INCHI: InChI=1/C25H49NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-25(29)30-23(21-24(27)28)22-26(2,3)4/h23H,5-22H2,1-4H3
name: stearoylcarnitine
initial amount: NaN
initial concentration: 1.0
constant: false

metaR ECOAH12m
notes: GENE_ASSOCIATION: (1892.1) or (3030.1) and (3032.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 4.2.1.17 Confidence Level: 2 AUTHORS: PMID:9073515 NOTES:MM. based on assigned short chain enoyl-CoA hydratase activity
fast: false
is described by: ECO:0000304
is version of: http://identifiers.org/ec-code/4.2.1.17
is: SBO:0000176
modifier: MODEL1310110042#
type: Reaction
name: 3-hydroxyacyl-CoA dehydratase (3-hydroxyisobutyryl-CoA) (mitochondria)
kinetic law: MODEL1310110042#
product: MODEL1310110042#
reversible: true
reactant: MODEL1310110042#
is version of: http://identifiers.org/ec-code/2.3.1.16

http://identifiers.org/biomodels.db/MODEL1310110042#_835025dc_eeae_4943_805e_fb33ffb6a019
is encoded by: hsa:10380
constant: false
name: BPNT1
boundary condition: true
is: SBO:0000252
initial amount: NaN
initial concentration: NaN
is: O95861
type: Species
has only substance units: false

metaR RADH2
type: Reaction
kinetic law: MODEL1310110042#
name: retinal dehydrogenase (NADPH)
is described by: ECO:0000000
fast: false
is: SBO:0000176
reactant: MODEL1310110042#
reversible: true
product: MODEL1310110042#
notes: GENE_ASSOCIATION: SUBSYSTEM: Vitamin A metabolism EC Number: Confidence Level: 2 AUTHORS: PMID:1503811 NOTES:IT

http://identifiers.org/biomodels.db/MODEL1310110042#_5a466804_066d_47e1_b506_e6400f55120d
initial amount: NaN
initial concentration: NaN
boundary condition: true
has only substance units: false
is: A8K7J7
name: HK1
is encoded by: hsa:3098
constant: false
type: Species
is: SBO:0000252

metaM ksii core4 pre3 g
name: keratan sulfate II biosynthesis, precursor 3
type: Species
is: HMDB00175
initial amount: NaN
boundary condition: false
initial concentration: 1.0
constant: false
notes: FORMULA: C55H89N5O38X CHARGE: -1
is: C00130
has only substance units: false
is: CHEBI:58053
is: SBO:0000247

metaR r0390
is described by: ECO:0000000
reactant: MODEL1310110042#
type: Reaction
fast: false
product: MODEL1310110042#
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 3.2.1.10 Confidence Level: 0 AUTHORS: PMID:17194452 NOTES:
is: SBO:0000176
reversible: true
name: Isomaltose 6-alpha-D-glucanohydrolase Starch and sucrose metabolism EC:3.2.1.10
kinetic law: MODEL1310110042#

metaR r0716
fast: false
is described by: ECO:0000000
type: Reaction
reversible: false
product: MODEL1310110042#
reactant: MODEL1310110042#
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 4.2.1.17 Confidence Level: 0 AUTHORS: PMID:8012501,PMID:8188243 NOTES:
name: (S)-3-Hydroxyhexadecanoyl-CoA hydro-lyase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:4.2.1.17
kinetic law: MODEL1310110042#
is: SBO:0000176

metaM met L e
boundary condition: false
is: SBO:0000247
has only substance units: false
notes: FORMULA: C5H11NO2S CHARGE: 0 INCHI: InChI=1S/C5H11NO2S/c1-9-3-2-4(6)5(7)8/h4H,2-3,6H2,1H3,(H,7,8)/t4-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00075
is: HMDB00696
type: Species
initial amount: NaN
name: L-methionine
is: CHEBI:16643
initial concentration: 1.0
constant: false

http://identifiers.org/biomodels.db/MODEL1310110042#_4a96705e_802a_4a02_901b_f77aa844a811
initial concentration: NaN
is: SBO:0000252
constant: false
has only substance units: false
name: LYZL1
boundary condition: true
is: Q6UWQ5
initial amount: NaN
is encoded by: hsa:84569
type: Species

metaR HIVCRNe
kinetic law: MODEL1310110042#
product: MODEL1310110042#
reactant: MODEL1310110042#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of 3-hydroxy-isovaleryl carnitine into extra cellular space
type: Reaction

metaM sprm e
is: SBO:0000247
initial concentration: 1.0
is: CHEBI:45725
name: spermine(4+)
initial amount: NaN
has only substance units: false
type: Species
constant: false
notes: FORMULA: C10H30N4 CHARGE: 4 INCHI: InChI=1S/C10H26N4/c11-5-3-9-13-7-1-2-8-14-10-4-6-12/h13-14H,1-12H2 HEPATONET_1.0_ABBREVIATION: HC00525 EHMN_ABBREVIATION: C00750
boundary condition: false
is: HMDB01256

metaR EX h2o LPAREN e RPAREN
kinetic law: MODEL1310110042#
reactant: MODEL1310110042#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: H2O exchange
type: Reaction

metaM Rtotal2 c
initial concentration: 1.0
is: CHEBI:57876
is: HMDB01564
is: SBO:0000247
constant: false
boundary condition: false
name: R total 2 position
notes: FORMULA: CO2FULLR2 CHARGE: -1
type: Species
has only substance units: false
initial amount: NaN

metaM g1p c
has only substance units: false
is: HMDB01586
is: CHEBI:58601
boundary condition: false
notes: FORMULA: C6H11O9P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00103 EHMN_ABBREVIATION: C00103
initial concentration: 1.0
initial amount: NaN
type: Species
is: C00103
constant: false
is: SBO:0000247
name: D-Glucose 1-phosphate

metaR SPHS1Pte
type: Reaction
reactant: MODEL1310110042#
is described by: ECO:0000000
fast: false
product: MODEL1310110042#
kinetic law: MODEL1310110042#
is: SBO:0000185
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10751414 NOTES:unknown mechanism, however sphs1p is known to have intracellular and extracellular activity and signal transduction functions (PMID: 10751414). NJ
name: sphingosine-1-phosphate transport

metaM dmnoncoa m
initial amount: NaN
type: Species
name: 4,8 dimethylnonanoyl-CoA
has only substance units: false
notes: FORMULA: C32H54N7O17P3S CHARGE: -4 INCHI: InChI=1/C32H56N7O17P3S/c1-19(2)7-6-8-20(3)9-10-23(41)60-14-13-34-22(40)11-12-35-30(44)27(43)32(4,5)16-53-59(50,51)56-58(48,49)52-15-21-26(55-57(45,46)47)25(42)31(54-21)39-18-38-24-28(33)36-17-37-29(24)39/h17-21,25-27,31,42-43H,6-16H2,1-5H3,(H,34,40)(H,35,44)(H,48,49)(H,50,51)(H2,33,36,37)(H2,45,46,47)/t20?,21-,25-,26-,27?,31-/m1/s1
is: HMDB11604
is: SBO:0000247
constant: false
boundary condition: false
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110042#_7cfec381_3550_43bf_80ae_6768faa546c9
constant: false
is: SBO:0000252
boundary condition: true
is encoded by: hsa:513
has only substance units: false
name: ATP5D
initial concentration: NaN
type: Species
initial amount: NaN

metaM glcur l
name: D-glucuronate
constant: false
type: Species
is: SBO:0000247
initial concentration: 1.0
has only substance units: false
boundary condition: false
is: CHEBI:15748
is: HMDB00127
initial amount: NaN
notes: FORMULA: C6H9O7 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00182 EHMN_ABBREVIATION: C00191

http://identifiers.org/biomodels.db/MODEL1310110042#_eb479782_2e32_4a8a_af82_1f7d04069731
has part: P22392
constant: false
boundary condition: true
is: SBO:0000297
initial concentration: NaN
initial amount: NaN
has only substance units: false
has part: P15531
name: NME1:NME2
is encoded by: hsa:4830
type: Species
is encoded by: hsa:4831

http://identifiers.org/biomodels.db/MODEL1310110042#_3c9fca46_2b5b_4eb7_b771_305e4bbeeb3f
is: SBO:0000252
boundary condition: true
type: Species
name: OGDH
initial concentration: NaN
constant: false
is: Q02218
is encoded by: hsa:4967
initial amount: NaN
has only substance units: false

metaR TETTET6t
type: Reaction
is: SBO:0000185
reversible: true
kinetic law: MODEL1310110042#
product: MODEL1310110042#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11788354,PMID:12864740 NOTES:NJ
name: fatty acid transport via diffusion
is described by: ECO:0000000
fast: false
reactant: MODEL1310110042#

metaR FUMAC
kinetic law: MODEL1310110042#
reversible: false
is described by: ECO:0000269
product: MODEL1310110042#
is version of: http://identifiers.org/ec-code/3.7.1.2
name: fumarylacetoacetase
modifier: MODEL1310110042#
reactant: MODEL1310110042#
notes: GENE_ASSOCIATION: (2184.1) SUBSYSTEM: Tyrosine metabolism EC Number: 3.7.1.2 Confidence Level: 4 AUTHORS: NOTES:NCD
fast: false
is: SBO:0000176
type: Reaction

metaR AG13T3g
modifier: MODEL1310110042#
reactant: MODEL1310110042#
notes: GENE_ASSOCIATION: (10331.1) or (11041.1) or (374907.2) or (10678.1) or (79369.1) or (374907.1) or (10678.2) or (93010.1) or (146712.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.149 Confidence Level: 4 AUTHORS: PMID:10747980,PMID:11042166,PMID:12061784,PMID:12512857,PMID:15560372,PMID:15620693,PMID:9405606 NOTES:NCD
kinetic law: MODEL1310110042#
product: MODEL1310110042#
is described by: ECO:0000000
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.4.1.149
type: Reaction
name: N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase, Golgi apparatus
fast: false
reversible: false

metaR KSII CORE4tly
name: keratan sulfate II (core 4) transport, extracellular to lysosome
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 2 AUTHORS: NOTES:
reversible: false
fast: false
kinetic law: MODEL1310110042#
reactant: MODEL1310110042#
product: MODEL1310110042#
is described by: ECO:0000000
type: Reaction

metaM pnto R e
type: Species
boundary condition: false
name: (R)-Pantothenate
is: HMDB00210
is: SBO:0000247
notes: FORMULA: C9H16NO5 CHARGE: -1 INCHI: InChI=1S/C9H17NO5/c1-9(2,5-11)7(14)8(15)10-4-3-6(12)13/h7,11,14H,3-5H2,1-2H3,(H,10,15)(H,12,13) HEPATONET_1.0_ABBREVIATION: HC00568
has only substance units: false
initial amount: NaN
constant: false
is: CHEBI:7916
initial concentration: 1.0

metaR RE1796M
reversible: true
is described by: ECO:0000000
is: SBO:0000176
reactant: MODEL1310110042#
fast: false
product: MODEL1310110042#
is version of: http://identifiers.org/ec-code/1.1.1.145
type: Reaction
kinetic law: MODEL1310110042#
modifier: MODEL1310110042#
notes: GENE_ASSOCIATION: (3283.1) or (3284.1) SUBSYSTEM: Bile acid synthesis EC Number: 5.3.3.1 Confidence Level: 0 AUTHORS: PMID:10599696,PMID:11067870,PMID:11454857,PMID:1401999 NOTES:
name: RE1796

metaR EX nh4 LPAREN e RPAREN
kinetic law: MODEL1310110042#
reactant: MODEL1310110042#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Ammonia exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110042#_b4cba781_6029_4ed2_8fde_6281a94a9456
constant: false
initial amount: NaN
has only substance units: false
type: Species
is: Q16836
is: SBO:0000252
boundary condition: true
name: HADH
is encoded by: hsa:3033
initial concentration: NaN

metaR r0179
is: SBO:0000176
reversible: true
name: Succinate-semialdehyde:NADP+ oxidoreductase Glutamate metabolism / Tyrosine metabolism / Butanoate metabolism EC:1.2.1.16
kinetic law: MODEL1310110042#
modifier: MODEL1310110042#
fast: false
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/1.1.1.27
product: MODEL1310110042#
notes: GENE_ASSOCIATION: (AI656480.1) or (BE042354.1) or (3939.1) or (92483.1) or (3945.1) or (3948.1) SUBSYSTEM: Glutamate metabolism EC Number: 1.2.1.16 Confidence Level: 0 AUTHORS: PMID:4066712,PMID:7814412 NOTES:
reactant: MODEL1310110042#
type: Reaction

metaM docohepcoa m
initial amount: NaN
notes: FORMULA: C43H60N7O17P3S CHARGE: -4
is: SBO:0000247
name: 2,4,7,10,13,16,19-docosaheptenoylcoa
initial concentration: 1.0
is: http://identifiers.org/pubchem.compound/24892790
constant: false
has only substance units: false
type: Species
boundary condition: false

metaM h2o l
notes: FORMULA: H2O CHARGE: 0 INCHI: InChI=1S/H2O/h1H2 HEPATONET_1.0_ABBREVIATION: HC00011 EHMN_ABBREVIATION: C00001
initial concentration: 1.0
name: water
has only substance units: false
is: CHEBI:15377
is: SBO:0000247
boundary condition: false
constant: false
type: Species
initial amount: NaN
is: HMDB02111

http://identifiers.org/biomodels.db/MODEL1310110042#_e7af56fd_aaf6_489c_a773_002536723c14
initial concentration: NaN
is: Q53Y25
initial amount: NaN
type: Species
is: SBO:0000252
has only substance units: false
constant: false
is encoded by: hsa:2645
boundary condition: true
name: GCK

http://identifiers.org/biomodels.db/MODEL1310110042#_7e454d06_4a3a_4a09_b598_b406b5a88c3b
constant: false
type: Species
boundary condition: true
initial concentration: NaN
name: TPH1
initial amount: NaN
is encoded by: hsa:7166
is: SBO:0000252
is: P17752
has only substance units: false

metaM cmpacna g
constant: false
initial amount: NaN
boundary condition: false
is: SBO:0000247
initial concentration: 1.0
is: CHEBI:57812
has only substance units: false
type: Species
notes: FORMULA: C20H29N4O16P CHARGE: -2 INCHI: InChI=1S/C20H31N4O16P/c1-7(26)22-12-8(27)4-20(18(32)33,39-16(12)13(29)9(28)5-25)40-41(35,36)37-6-10-14(30)15(31)17(38-10)24-3-2-11(21)23-19(24)34/h2-3,8-10,12-17,25,27-31H,4-6H2,1H3,(H,22,26)(H,32,33)(H,35,36)(H2,21,23,34)/p-2/t8-,9+,10+,12+,13+,14+,15+,16+,17+,20+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00126 EHMN_ABBREVIATION: C00128
is: HMDB01176
name: CMP-N-acetyl-beta-neuraminate(2-)

http://identifiers.org/biomodels.db/MODEL1310110042#_9a4399cd_3134_4c7e_b927_2f47bbfa5300
has only substance units: false
initial amount: NaN
type: Species
boundary condition: true
name: ALAS1
is: SBO:0000252
initial concentration: NaN
constant: false
is: P13196
is encoded by: hsa:211

http://identifiers.org/biomodels.db/MODEL1310110042#_e0a7ab77_31f2_453c_909b_94b471f63164
is: SBO:0000252
is encoded by: hsa:29920
has only substance units: false
is: Q96C36
type: Species
constant: false
initial amount: NaN
boundary condition: true
initial concentration: NaN
name: PYCR2

metaR BMTer U
is: SBO:0000176
kinetic law: MODEL1310110042#
name: B mannosyltransferase, endoplasmic reticulum
product: MODEL1310110042#
type: Reaction
notes: GENE_ASSOCIATION: (9488.1) SUBSYSTEM: Phosphatidylinositol phosphate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:8861954 NOTES:NCD
is described by: ECO:0000000
reactant: MODEL1310110042#
fast: false
modifier: MODEL1310110042#
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110042#_f9a83d93_3e55_4635_9f7c_6b2b834dac9c
is: SBO:0000252
type: Species
initial concentration: NaN
name: ALAS1
is: Q5JAM2
boundary condition: true
has only substance units: false
initial amount: NaN
constant: false
is encoded by: hsa:211

metaR S6TASE15ly
is version of: http://identifiers.org/ec-code/3.1.6.14
is described by: ECO:0000000
modifier: MODEL1310110042#
fast: false
notes: GENE_ASSOCIATION: (2799.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.1.6.14 Confidence Level: 4 AUTHORS: PMID:3196333,PMID:3689314,PMID:3689315 NOTES:NCD
type: Reaction
is: SBO:0000176
kinetic law: MODEL1310110042#
reversible: true
reactant: MODEL1310110042#
product: MODEL1310110042#
name: N-acetylglucosamine-6-sulfatase, lysosomal

http://identifiers.org/biomodels.db/MODEL1310110042#_63fc8ab8_0624_4cdc_a38c_0b778a613776
is: SBO:0000252
name: PDE9A
initial amount: NaN
constant: false
initial concentration: NaN
boundary condition: true
has only substance units: false
is encoded by: hsa:5152
type: Species

http://identifiers.org/biomodels.db/MODEL1310110042#_ee8de7bd_6eef_42b7_abf2_0269c3dd0b9e
initial concentration: NaN
is encoded by: hsa:1375
name: CPT1B
boundary condition: true
type: Species
constant: false
is: SBO:0000252
has only substance units: false
is: E9PCP2
initial amount: NaN

metaR EX orn LPAREN e RPAREN
kinetic law: MODEL1310110042#
reactant: MODEL1310110042#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Ornithine exchange
type: Reaction

metaM glyb m
is: SBO:0000247
is: HMDB00043
has only substance units: false
name: glycine betaine
constant: false
is: CHEBI:17750
type: Species
initial concentration: 1.0
initial amount: NaN
boundary condition: false
notes: FORMULA: C5H11NO2 CHARGE: 0 INCHI: InChI=1S/C5H11NO2/c1-6(2,3)4-5(7)8/h4H2,1-3H3 HEPATONET_1.0_ABBREVIATION: HC00515 EHMN_ABBREVIATION: C00719

metaR C161CPT2
fast: false
product: MODEL1310110042#
type: Reaction
modifier: MODEL1310110042#
notes: GENE_ASSOCIATION: (1376.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: NOTES:TDV
kinetic law: MODEL1310110042#
is: SBO:0000176
name: transport of Hexadecenoyl-CoA into mitochondrial matrix
is version of: http://identifiers.org/ec-code/2.3.1.21
reactant: MODEL1310110042#
is described by: ECO:0000000
reversible: false

metaM Rtotal2 e
is: CHEBI:3554
is: C00255
constant: false
is: HMDB00244
initial concentration: 1.0
is: SBO:0000247
type: Species
name: R total 2 position
initial amount: NaN
boundary condition: false
notes: FORMULA: CO2FULLR2 CHARGE: -1
has only substance units: false

metaR r0178
reversible: true
reactant: MODEL1310110042#
modifier: MODEL1310110042#
is: SBO:0000176
name: Succinate-semialdehyde:NAD+ oxidoreductase Glutamate metabolism / Tyrosine metabolism / Butanoate metabolism EC:1.2.1.24 EC:1.2.1.16
is described by: ECO:0000000
kinetic law: MODEL1310110042#
is version of: http://identifiers.org/ec-code/2.5.1.21
product: MODEL1310110042#
type: Reaction
notes: GENE_ASSOCIATION: (2222.1) SUBSYSTEM: Glutamate metabolism EC Number: 1.2.1.24 Confidence Level: 0 AUTHORS: PMID:3190233,PMID:656447,PMID:7616245,PMID:7814412 NOTES:
fast: false

metaR SCPx
type: Reaction
kinetic law: MODEL1310110042#
reversible: false
modifier: MODEL1310110042#
name: peroxisomal thiolase 2
notes: GENE_ASSOCIATION: (6342.1) SUBSYSTEM: Bile acid synthesis EC Number: Confidence Level: 4 AUTHORS: NOTES:SCP has two transcripts, second isoform specific to peroxisomes, first is specific for cyt and mit need to double check stoichiometry - reaction cofactors (additional coa + release of prop coa) from BM (Roche) Biochemical Pathways NJ
reactant: MODEL1310110042#
is described by: ECO:0000269
fast: false
product: MODEL1310110042#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.3.1.176

metaM tststerones c
has only substance units: false
initial concentration: 1.0
is: SBO:0000247
boundary condition: false
type: Species
is: HMDB02833
notes: FORMULA: C19H27O5S CHARGE: -1 INCHI: InChI=1/C19H28O5S/c1-18-9-7-13(20)11-12(18)3-4-14-15-5-6-17(24-25(21,22)23)19(15,2)10-8-16(14)18/h11,14-17H,3-10H2,1-2H3,(H,21,22,23)/t14-,15-,16-,17-,18-,19-/m0/s1
name: testosterone sulfate
initial amount: NaN
constant: false

http://identifiers.org/biomodels.db/MODEL1310110042#_4f859534_137c_47bb_8fee_e6e4174ee3a5
is: Q9BWD1
initial amount: NaN
initial concentration: NaN
boundary condition: true
constant: false
has only substance units: false
is encoded by: hsa:39
type: Species
is: SBO:0000252
name: ACAT2

metaM lanost r
initial concentration: 1.0
boundary condition: false
is: CHEBI:16521
constant: false
notes: FORMULA: C30H50O CHARGE: 0 INCHI: InChI=1S/C30H50O/c1-20(2)10-9-11-21(3)22-14-18-30(8)24-12-13-25-27(4,5)26(31)16-17-28(25,6)23(24)15-19-29(22,30)7/h10,21-22,25-26,31H,9,11-19H2,1-8H3/t21-,22-,25+,26+,28-,29-,30+/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00833 EHMN_ABBREVIATION: C01724
initial amount: NaN
is: HMDB01251
name: lanosterol
type: Species
has only substance units: false
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110042#_8669a5cd_958c_4534_ada3_070c788e5857
initial concentration: NaN
boundary condition: true
is: SBO:0000252
has only substance units: false
constant: false
initial amount: NaN
is: Q8WXF9
name: SLC2A11
type: Species
is encoded by: hsa:66035

metaR AG13T16g
is: SBO:0000176
modifier: MODEL1310110042#
name: N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase, Golgi apparatus
reversible: false
product: MODEL1310110042#
is version of: http://identifiers.org/ec-code/2.4.1.149
type: Reaction
reactant: MODEL1310110042#
notes: GENE_ASSOCIATION: (79369.1) or (10678.1) or (11041.1) or (146712.1) or (374907.1) or (93010.1) or (374907.2) or (10678.2) or (10331.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.149 Confidence Level: 4 AUTHORS: PMID:10747980,PMID:11042166,PMID:12061784,PMID:12512857,PMID:15560372,PMID:15620693,PMID:9405606 NOTES:NCD
kinetic law: MODEL1310110042#
is described by: ECO:0000000
fast: false

http://identifiers.org/biomodels.db/MODEL1310110042#_d21a50b5_1b91_48e5_b2e7_03cd0d9d4724
name: SLC26A6
initial amount: NaN
is encoded by: hsa:65010
type: Species
constant: false
is: Q9NQU1
initial concentration: NaN
has only substance units: false
boundary condition: true
is: SBO:0000252

metaM apoC m
boundary condition: false
constant: false
is: SBO:0000247
notes: FORMULA: XH CHARGE: 0
name: Apocarboxlase (no lys residue)
is: CHEBI:32551
has only substance units: false
type: Species
is: HMDB00182
initial concentration: 1.0
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110042#_a86554cc_73cb_4972_8b93_311b4d8dd32d
type: Species
constant: false
initial concentration: NaN
boundary condition: true
has only substance units: false
name: GPX2
is encoded by: hsa:2877
initial amount: NaN
is: SBO:0000252
is: P18283

metaR MECOALm
is: SBO:0000176
product: MODEL1310110042#
is described by: ECO:0000212
type: Reaction
modifier: MODEL1310110042#
kinetic law: MODEL1310110042#
reversible: true
name: mesaconate--CoA ligase (ADP-forming), mitochondrial
is version of: http://identifiers.org/ec-code/6.2.1.5
fast: false
reactant: MODEL1310110042#
is version of: http://identifiers.org/ec-code/6.2.1.4
notes: GENE_ASSOCIATION: (8802.1 and 8803.1) SUBSYSTEM: C5-branched dibasic acid metabolism EC Number: 6.2.1.5 Confidence Level: 1 AUTHORS: PMID:13783048 NOTES:NCD

http://identifiers.org/biomodels.db/MODEL1310110042#_cf2b5f07_cc6c_4ae5_9e71_87d7c0f4d66f
type: Species
is encoded by: hsa:2954
constant: false
has only substance units: false
name: GSTZ1
initial concentration: NaN
initial amount: NaN
is: SBO:0000252
is: A6NED0
boundary condition: true

metaR GLCt2 2
kinetic law: MODEL1310110042#
notes: GENE_ASSOCIATION: (6523.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:11024018,PMID:11034615,PMID:12748858,PMID:2490366,PMID:8063771 NOTES:
reversible: true
product: MODEL1310110042#
reactant: MODEL1310110042#
type: Reaction
is: SBO:0000185
modifier: MODEL1310110042#
name: D-glucose transport in via proton symport
is described by: ECO:0000269
fast: false

http://identifiers.org/biomodels.db/MODEL1310110042#_8d85850b_df7d_4333_ad1b_407d324f8e9b
initial amount: NaN
boundary condition: true
is: Q10472
constant: false
has only substance units: false
is: SBO:0000252
is encoded by: hsa:2589
type: Species
initial concentration: NaN
name: GALNT1

metaR SIAT9g
fast: false
is version of: http://identifiers.org/ec-code/2.4.99.9
kinetic law: MODEL1310110042#
modifier: MODEL1310110042#
is: SBO:0000176
reversible: false
notes: GENE_ASSOCIATION: (8869.1) SUBSYSTEM: Sphingolipid metabolism EC Number: 2.4.99.9 Confidence Level: 4 AUTHORS: PMID:9822625 NOTES:NJ
name: Lactosylceramide alpha-2,3-sialyltransferase, Golgi apparatus
type: Reaction
is described by: ECO:0000000
product: MODEL1310110042#
reactant: MODEL1310110042#

metaM eicostetcrn m
is: SBO:0000247
boundary condition: false
notes: FORMULA: C27H45NO4 CHARGE: 0 INCHI: InChI=1/C27H46NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-27(31)32-25(23-26(29)30)24-28(2,3)4/h9-10,12-13,15-16,18-19,25H,5-8,11,14,17,20-24H2,1-4H3,(H,29,30)/q+1/p-1
name: Eicosatetranoyl carnitine
is: CHEBI:57312
type: Species
constant: false
initial concentration: 1.0
is: HMDB01356
has only substance units: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110042#_8af04959_d7a7_413c_b0a0_a058d939d202
name: PIP4K2C
constant: false
is: SBO:0000252
is encoded by: hsa:79837
is: B3KQV3
initial concentration: NaN
boundary condition: true
type: Species
initial amount: NaN
has only substance units: false

metaM h2o n
has only substance units: false
type: Species
boundary condition: false
initial concentration: 1.0
name: water
is: HMDB02111
is: SBO:0000247
notes: FORMULA: H2O CHARGE: 0 INCHI: InChI=1S/H2O/h1H2 HEPATONET_1.0_ABBREVIATION: HC00011 EHMN_ABBREVIATION: C00001
is: CHEBI:15377
initial amount: NaN
constant: false

metaR RE2541E
is: SBO:0000176
name: RE2541
modifier: MODEL1310110042#
reactant: MODEL1310110042#
product: MODEL1310110042#
fast: false
type: Reaction
kinetic law: MODEL1310110042#
is version of: http://identifiers.org/ec-code/3.2.1.31
is described by: ECO:0000000
reversible: true
notes: GENE_ASSOCIATION: (9365.1) SUBSYSTEM: Miscellaneous EC Number: 3.2.1.31 Confidence Level: 0 AUTHORS: PMID:10191290 NOTES:

metaM pnto R c
is: HMDB00210
notes: FORMULA: C9H16NO5 CHARGE: -1 INCHI: InChI=1S/C9H17NO5/c1-9(2,5-11)7(14)8(15)10-4-3-6(12)13/h7,11,14H,3-5H2,1-2H3,(H,10,15)(H,12,13) HEPATONET_1.0_ABBREVIATION: HC00568
is: SBO:0000247
name: (R)-Pantothenate
constant: false
is: CHEBI:7916
boundary condition: false
type: Species
initial amount: NaN
initial concentration: 1.0
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110042#_c56e619e_3d2e_47df_9d70_e69ee28c8010
name: NDUFB5
is: SBO:0000252
is encoded by: hsa:4711
initial amount: NaN
is: O43674
initial concentration: NaN
boundary condition: true
type: Species
constant: false
has only substance units: false

metaR C161CPT1
product: MODEL1310110042#
is described by: ECO:0000000
kinetic law: MODEL1310110042#
is version of: http://identifiers.org/ec-code/2.3.1.21
modifier: MODEL1310110042#
name: production of palmitoleoylcarnitine
type: Reaction
reversible: false
reactant: MODEL1310110042#
notes: GENE_ASSOCIATION: (1375.1) or (1375.3) or (1375.4) or (126129.1) or (1374.1) or (1375.2) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.21 Confidence Level: 4 AUTHORS: NOTES:TDV
fast: false
is: SBO:0000176

metaM 3tetd7ecoa m
boundary condition: false
name: 3-hydroxy tetradecenoyl-7-coa
initial concentration: 1.0
constant: false
notes: FORMULA: C35H56N7O18P3S CHARGE: -4
is: SBO:0000247
is: HMDB05066
initial amount: NaN
type: Species
has only substance units: false

metaR 4HPRO LTte
kinetic law: MODEL1310110042#
fast: false
product: MODEL1310110042#
reactant: MODEL1310110042#
reversible: true
is described by: ECO:0000134
is: SBO:0000185
name: Transport of trans-4-hydroxy-L-proline
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
type: Reaction

metaM arg L m
is: CHEBI:32682
is: SBO:0000247
initial amount: NaN
is: HMDB00517
notes: FORMULA: C6H15N4O2 CHARGE: 1 INCHI: InChI=1S/C6H14N4O2/c7-4(5(11)12)2-1-3-10-6(8)9/h4H,1-3,7H2,(H,11,12)(H4,8,9,10)/p+1/t4-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00065
initial concentration: 1.0
has only substance units: false
boundary condition: false
name: L-argininium(1+)
constant: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110042#_ccd65621_de8c_43ba_a4ef_db2be124561c
has only substance units: false
constant: false
type: Species
boundary condition: true
is: SBO:0000252
initial concentration: NaN
is encoded by: hsa:4718
initial amount: NaN
is: Q549M5
name: NDUFC2

metaM gdpfuc g
type: Species
is: HMDB01095
name: GDP-L-fucose(2-)
is: CHEBI:57984
initial amount: NaN
is: SBO:0000247
notes: FORMULA: C16H23N5O15P2 CHARGE: -2 INCHI: InChI=1S/C16H25N5O15P2/c1-4-7(22)9(24)11(26)15(33-4)35-38(30,31)36-37(28,29)32-2-5-8(23)10(25)14(34-5)21-3-18-6-12(21)19-16(17)20-13(6)27/h3-5,7-11,14-15,22-26H,2H2,1H3,(H,28,29)(H,30,31)(H3,17,19,20,27)/p-2/t4-,5+,7+,8+,9+,10+,11-,14+,15?/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00275 EHMN_ABBREVIATION: C00325
constant: false
boundary condition: false
initial concentration: 1.0
has only substance units: false

metaR HMGLm
product: MODEL1310110042#
fast: false
type: Reaction
notes: GENE_ASSOCIATION: (3155.1) or (54511.1) SUBSYSTEM: Cholesterol metabolism EC Number: 4.1.3.4 Confidence Level: 4 AUTHORS: PMID:11129331 NOTES:TV
name: hydroxymethylglutaryl-CoA lyase
modifier: MODEL1310110042#
is: SBO:0000176
reactant: MODEL1310110042#
kinetic law: MODEL1310110042#
is described by: ECO:0000134
is version of: http://identifiers.org/ec-code/4.1.3.4
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110042#_7c927541_c637_460d_8192_10d925b83bb0
is: SBO:0000252
constant: false
boundary condition: true
is encoded by: hsa:3632
initial amount: NaN
type: Species
initial concentration: NaN
name: INPP5A
has only substance units: false
is: Q14642

metaM tststerones e
is: SBO:0000247
has only substance units: false
initial concentration: 1.0
type: Species
is: HMDB02833
boundary condition: false
initial amount: NaN
constant: false
name: testosterone sulfate
notes: FORMULA: C19H27O5S CHARGE: -1 INCHI: InChI=1/C19H28O5S/c1-18-9-7-13(20)11-12(18)3-4-14-15-5-6-17(24-25(21,22)23)19(15,2)10-8-16(14)18/h11,14-17H,3-10H2,1-2H3,(H,21,22,23)/t14-,15-,16-,17-,18-,19-/m0/s1

metaR GLYOX
name: hydroxyacylglutathione hydrolase
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.1.2.6
kinetic law: MODEL1310110042#
notes: GENE_ASSOCIATION: (3029.1) or (84264.2) or (84264.1) SUBSYSTEM: Pyruvate metabolism EC Number: 3.1.2.6 Confidence Level: 4 AUTHORS: PMID:15117945,PMID:8550579 NOTES:IF
product: MODEL1310110042#
modifier: MODEL1310110042#
reversible: false
fast: false
reactant: MODEL1310110042#
type: Reaction
is described by: ECO:0000269

metaM ksi pre13 g
is: CHEBI:58053
boundary condition: false
notes: FORMULA: C143H231N10O111S3X CHARGE: -4
is: C00130
initial concentration: 1.0
is: SBO:0000247
initial amount: NaN
constant: false
has only substance units: false
name: keratan sulfate I biosynthesis, precursor 13
is: HMDB00175
type: Species

metaM h2o m
is: HMDB02111
has only substance units: false
is: SBO:0000247
name: H2O
initial concentration: 1.0
constant: false
is: C00001
type: Species
is: CHEBI:15377
notes: FORMULA: H2O CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00011 EHMN_ABBREVIATION: C00001
initial amount: NaN
boundary condition: false

metaR r2014
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
type: Reaction
reactant: MODEL1310110042#
product: MODEL1310110042#
reversible: false
kinetic law: MODEL1310110042#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.15
fast: false
is: SBO:0000185
modifier: MODEL1310110042#
is described by: ECO:0000000

metaM triodthy e
notes: FORMULA: C15H12I3NO4 CHARGE: 0 INCHI: InChI=1S/C15H12I3NO4/c16-9-6-8(1-2-13(9)20)23-14-10(17)3-7(4-11(14)18)5-12(19)15(21)22/h1-4,6,12,20H,5,19H2,(H,21,22)/t12-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00943 EHMN_ABBREVIATION: C02465
is: HMDB00265
name: 3,3',5-triiodo-L-thyronine
is: SBO:0000247
type: Species
boundary condition: false
is: CHEBI:18258
initial amount: NaN
constant: false
has only substance units: false
initial concentration: 1.0

metaM glyc3p c
initial amount: NaN
is: HMDB00126
has only substance units: false
initial concentration: 1.0
type: Species
notes: FORMULA: C3H7O6P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00095 EHMN_ABBREVIATION: C00093
is: C00093
boundary condition: false
is: CHEBI:57597
constant: false
is: SBO:0000247
name: Glycerol 3-phosphate

http://identifiers.org/biomodels.db/MODEL1310110042#_25c490b0_bb2a_4e1a_9129_d0b21bdd6466
has only substance units: false
is: P06865
initial amount: NaN
boundary condition: true
type: Species
initial concentration: NaN
constant: false
is: SBO:0000252
is encoded by: hsa:3073
name: HEXA

metaR LNLCCPT1
is version of: http://identifiers.org/ec-code/2.3.1.21
is: SBO:0000176
reversible: false
product: MODEL1310110042#
is described by: ECO:0000269
kinetic law: MODEL1310110042#
notes: GENE_ASSOCIATION: (1375.1) or (1375.3) or (1375.4) or (126129.1) or (1374.1) or (1375.2) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.21 Confidence Level: 4 AUTHORS: NOTES:NJ
type: Reaction
fast: false
name: carnitine O-palmitoyltransferase
reactant: MODEL1310110042#
modifier: MODEL1310110042#

http://identifiers.org/biomodels.db/MODEL1310110042#_093283be_4a96_4feb_8a25_f330abba7d69
boundary condition: true
type: Species
constant: false
is: SBO:0000252
is: B3KT84
initial amount: NaN
has only substance units: false
initial concentration: NaN
name: SDR16C5
is encoded by: hsa:195814

metaR EX maltpt LPAREN e RPAREN
kinetic law: MODEL1310110042#
reactant: MODEL1310110042#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: maltopentaose exchange
type: Reaction

metaR CITtbm
fast: false
notes: GENE_ASSOCIATION: (6576.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172 NOTES:antiport with PEP IF
kinetic law: MODEL1310110042#
is described by: ECO:0000269
reactant: MODEL1310110042#
type: Reaction
name: citrate transport, mitochondrial
modifier: MODEL1310110042#
product: MODEL1310110042#
reversible: true
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110042#_f1ac36ce_1b76_4b67_b021_d504f0c2ee1b
boundary condition: true
is: P00505
type: Species
is encoded by: hsa:2806
initial amount: NaN
name: GOT2
has only substance units: false
initial concentration: NaN
constant: false
is: SBO:0000252

metaM CE2432 m
notes: FORMULA: C35H52N7O17P3S CHARGE: -4 INCHI: InChI=1/C35H56N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-26(44)63-19-18-37-25(43)16-17-38-33(47)30(46)35(2,3)21-56-62(53,54)59-61(51,52)55-20-24-29(58-60(48,49)50)28(45)34(57-24)42-23-41-27-31(36)39-22-40-32(27)42/h8-9,11-12,14-15,22-24,28-30,34,45-46H,4-7,10,13,16-21H2,1-3H3,(H,37,43)(H,38,47)(H,51,52)(H,53,54)(H2,36,39,40)(H2,48,49,50)/p-4/b9-8-,12-11-,15-14+/t24-,28+,29+,30u,34-/m0/s1 EHMN_ABBREVIATION: CE2432
is: CHEBI:57795
type: Species
boundary condition: false
initial amount: NaN
constant: false
initial concentration: 1.0
name: trans-2-cis,cis-5,8-tetradecatrienoyl-CoA
has only substance units: false
is: SBO:0000247

metaM ppi e
constant: false
has only substance units: false
is: CHEBI:33019
initial concentration: 1.0
type: Species
notes: FORMULA: HO7P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00023 EHMN_ABBREVIATION: C00013
is: SBO:0000247
initial amount: NaN
name: Diphosphate
is: C00013
is: HMDB00250
boundary condition: false

metaR PGI
kinetic law: MODEL1310110042#
reversible: true
is version of: http://identifiers.org/ec-code/5.3.1.9
reactant: MODEL1310110042#
is: SBO:0000176
is described by: ECO:0000134
name: glucose-6-phosphate isomerase
modifier: MODEL1310110042#
type: Reaction
product: MODEL1310110042#
notes: GENE_ASSOCIATION: (2821.1) SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: 5.3.1.9 Confidence Level: 0 AUTHORS: PMID:19064002,PMID:2241164,PMID:8530082 NOTES:
fast: false

http://identifiers.org/biomodels.db/MODEL1310110042#_a929e960_78bf_48d1_807b_4f37d090ee64
type: Species
constant: false
initial amount: NaN
is encoded by: hsa:9187
initial concentration: NaN
name: SLC24A1
is: B4DUG1
is: SBO:0000252
has only substance units: false
boundary condition: true

metaR P4507A1r
fast: false
is: SBO:0000176
reactant: MODEL1310110042#
kinetic law: MODEL1310110042#
reversible: false
is version of: http://identifiers.org/ec-code/1.14.13.17
type: Reaction
is described by: ECO:0000269
modifier: MODEL1310110042#
product: MODEL1310110042#
name: cytochrome P450, family 7, subfamily A, polypeptide 1
notes: GENE_ASSOCIATION: (1581.1) SUBSYSTEM: Bile acid synthesis EC Number: 1.14.13.17 Confidence Level: 4 AUTHORS: NOTES:

metaM h2o x
is: SBO:0000247
is: HMDB02111
is: C00001
is: CHEBI:15377
constant: false
initial concentration: 1.0
type: Species
boundary condition: false
name: H2O
initial amount: NaN
notes: FORMULA: H2O CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00011 EHMN_ABBREVIATION: C00001
has only substance units: false

metaR ARACHDCOAtx
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: NOTES:interaction between peroxisomes and ER (some enzymes on the outer membrane) NJ
type: Reaction
name: fatty acid intracellular transport
reactant: MODEL1310110042#
is: SBO:0000185
reversible: true
product: MODEL1310110042#
kinetic law: MODEL1310110042#
is described by: ECO:0000000
fast: false

metaM tdchola e
notes: FORMULA: C26H45NO6S CHARGE: 0 INCHI: InChI=1S/C26H45NO6S/c1-16(4-7-23(30)27-12-13-34(31,32)33)19-5-6-20-24-21(9-11-26(19,20)3)25(2)10-8-18(28)14-17(25)15-22(24)29/h16-22,24,28-29H,4-15H2,1-3H3,(H,27,30)(H,31,32,33)/p-1/t16-,17+,18-,19-,20+,21+,22-,24+,25+,26-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01471 EHMN_ABBREVIATION: C05465
is: CHEBI:9407
has only substance units: false
is: SBO:0000247
is: HMDB00951
name: taurochenodeoxycholate
initial amount: NaN
constant: false
type: Species
boundary condition: false
initial concentration: 1.0

metaR SUCCCROT
kinetic law: MODEL1310110042#
product: MODEL1310110042#
reactant: MODEL1310110042#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: production of succinyl carnitine
type: Reaction

metaR 3AIBTm
is described by: ECO:0000304
reversible: true
notes: GENE_ASSOCIATION: (18.1) or (18.2) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 2.6.19.4 Confidence Level: 2 AUTHORS: NOTES:NCD
is: SBO:0000176
fast: false
product: MODEL1310110042#
is version of: http://identifiers.org/ec-code/2.6.1.19
modifier: MODEL1310110042#
kinetic law: MODEL1310110042#
reactant: MODEL1310110042#
type: Reaction
name: L-3-aminoisobutyrate transaminase, mitochondrial

metaR r0287
reactant: MODEL1310110042#
name: Acetyl-CoA:acetyl-CoA C-acetyltransferase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:2.3.1.16
is: SBO:0000176
reversible: false
is described by: ECO:0000000
fast: false
modifier: MODEL1310110042#
kinetic law: MODEL1310110042#
type: Reaction
product: MODEL1310110042#
notes: GENE_ASSOCIATION: (6576.1) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.16 Confidence Level: 0 AUTHORS: PMID:10806397,PMID:1121274,PMID:1679347,PMID:1735445,PMID:1979337,PMID:2048733,PMID:3194209,PMID:6378901,PMID:8241273 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110042#_9dd9fb65_d183_42c2_8fc6_f6309c817288
boundary condition: true
initial amount: NaN
initial concentration: NaN
has only substance units: false
type: Species
is: P00441
is: SBO:0000252
is encoded by: hsa:6647
constant: false
name: SOD1

metaR ADSS
kinetic law: MODEL1310110042#
product: MODEL1310110042#
modifier: MODEL1310110042#
is version of: http://identifiers.org/ec-code/6.3.4.4
is described by: ECO:0000134
name: adenylosuccinate synthase
notes: GENE_ASSOCIATION: (159.1) or (122622.1) or (122622.2) SUBSYSTEM: Nucleotide interconversion EC Number: 6.3.4.4 Confidence Level: 2 AUTHORS: PMID:1592113 NOTES:r0277
is: SBO:0000176
reversible: false
fast: false
reactant: MODEL1310110042#
type: Reaction

metaR C40CPT1
kinetic law: MODEL1310110042#
product: MODEL1310110042#
reactant: MODEL1310110042#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: production of butyrylcarnitine
type: Reaction

metaM glcur r
notes: FORMULA: C6H9O7 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00182 EHMN_ABBREVIATION: C00191
initial concentration: 1.0
boundary condition: false
is: SBO:0000247
constant: false
has only substance units: false
type: Species
is: HMDB00127
initial amount: NaN
name: D-glucuronate
is: CHEBI:15748

metaR FAOXTC182TC162m
kinetic law: MODEL1310110042#
product: MODEL1310110042#
reactant: MODEL1310110042#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation trans(C18:2-->C16:2)m
type: Reaction

metaR UMPK5n
name: UMP kinase (dATP),nuclear
modifier: MODEL1310110042#
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
product: MODEL1310110042#
fast: false
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/2.7.4.14
kinetic law: MODEL1310110042#
reversible: true
type: Reaction
reactant: MODEL1310110042#
is: SBO:0000176

metaM rbt e
is: HMDB00508
is: SBO:0000247
is: CHEBI:15963
initial amount: NaN
has only substance units: false
type: Species
constant: false
boundary condition: false
initial concentration: 1.0
notes: FORMULA: C5H12O5 CHARGE: 0 INCHI: InChI=1S/C5H12O5/c6-1-3(8)5(10)4(9)2-7/h3-10H,1-2H2/t3-,4+,5- HEPATONET_1.0_ABBREVIATION: HC00380
name: D-ribitol

metaM crn m
initial amount: NaN
is: CHEBI:16347
notes: FORMULA: C7H15NO3 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00270 EHMN_ABBREVIATION: C00318
constant: false
is: C00318
is: HMDB00062
boundary condition: false
initial concentration: 1.0
name: L-Carnitine
has only substance units: false
type: Species
is: SBO:0000247

metaM 4h2oglt m
is: CHEBI:17742
boundary condition: false
initial amount: NaN
constant: false
name: 4-hydroxy-2-oxoglutarate(2-)
initial concentration: 1.0
type: Species
has only substance units: false
notes: FORMULA: C5H4O6 CHARGE: -2 INCHI: InChI=1S/C5H6O6/c6-2(4(8)9)1-3(7)5(10)11/h2,6H,1H2,(H,8,9)(H,10,11)/p-2
is: HMDB02070
is: SBO:0000247

metaR CSNAT3x
is version of: http://identifiers.org/ec-code/2.3.1.7
kinetic law: MODEL1310110042#
name: carnitine O-aceyltransferase, peroxisomal
is: SBO:0000176
type: Reaction
product: MODEL1310110042#
notes: GENE_ASSOCIATION: (1384.2) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.7 Confidence Level: 4 AUTHORS: PMID:7654220,PMID:7829107 NOTES:NJ
modifier: MODEL1310110042#
reactant: MODEL1310110042#
fast: false
reversible: true
is described by: ECO:0000269

metaR NDPK8n
reactant: MODEL1310110042#
reversible: true
product: MODEL1310110042#
type: Reaction
modifier: MODEL1310110042#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.7.4.6
notes: GENE_ASSOCIATION: (4831.1 and 4830.1) or (4830.2 and 4831.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.6 Confidence Level: 4 AUTHORS: PMID:7050910 NOTES:Many nucleoside diphosphates (eight described) can act as acceptors. While many ribo- and deoxyribonucleoside triphosphates can act as donors, only ATP is chosen as a donor to minimize the number of total reactions.. Presence in the nucleus
kinetic law: MODEL1310110042#
is described by: ECO:0000304
fast: false
name: nucleoside-diphosphate kinase (ATP:dADP), nuclear

http://identifiers.org/biomodels.db/MODEL1310110042#_45d95024_bb7b_4726_969b_3c3d5328b183
type: Species
is encoded by: hsa:10257
constant: false
is: SBO:0000252
name: ABCC4
boundary condition: true
initial amount: NaN
initial concentration: NaN
is: O15439
has only substance units: false

metaR ACOX2x
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.17.99.3
is described by: ECO:0000269
name: acyl-Coenzyme A oxidase 2, branched chain
kinetic law: MODEL1310110042#
product: MODEL1310110042#
notes: GENE_ASSOCIATION: (8309.1) SUBSYSTEM: Bile acid synthesis EC Number: 1.3.3.6 Confidence Level: 4 AUTHORS: NOTES:noted in uniprot to have FAD as cofactor - further reaction specific lit evidence not found to support or contradict, see Baumgart et al PNAS (1996) 93: 13748-13753 NJ
reversible: false
type: Reaction
reactant: MODEL1310110042#
fast: false
modifier: MODEL1310110042#

metaM tetdec2crn e
is: SBO:0000247
is: HMDB05066
initial amount: NaN
constant: false
name: tetradecadienoyl carnitine
notes: FORMULA: C21H37NO4 CHARGE: 0
boundary condition: false
type: Species
has only substance units: false
initial concentration: 1.0

metaM didp n
initial amount: NaN
boundary condition: false
notes: FORMULA: C10H11N4O10P2 CHARGE: -3 INCHI: InChI=1S/C10H14N4O10P2/c15-5-1-7(14-4-13-8-9(14)11-3-12-10(8)16)23-6(5)2-22-26(20,21)24-25(17,18)19/h3-7,15H,1-2H2,(H,20,21)(H,11,12,16)(H2,17,18,19)/t5-,6+,7+/m0/s1 EHMN_ABBREVIATION: C01344
has only substance units: false
initial concentration: 1.0
name: dIDP
is: CHEBI:28823
is: HMDB03536
is: SBO:0000247
constant: false
type: Species

metaR FAOXC11C9m
kinetic law: MODEL1310110042#
product: MODEL1310110042#
reactant: MODEL1310110042#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C11-->C9)m
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110042#_cdce4674_e4ec_4226_809c_641526b97730
has only substance units: false
initial concentration: NaN
constant: false
boundary condition: true
initial amount: NaN
is encoded by: hsa:2109
is: SBO:0000297
type: Species
has part: P38117
name: ETFA:ETFB

http://identifiers.org/biomodels.db/MODEL1310110042#_1b717a0e_f2b8_42eb_8fb2_ed942765261c
initial amount: NaN
constant: false
type: Species
is: SBO:0000252
has only substance units: false
name: NDUFA2
is encoded by: hsa:4695
initial concentration: NaN
boundary condition: true
is: O43678

http://identifiers.org/biomodels.db/MODEL1310110042#_57f96b99_295c_4ebc_8ea6_423545b76546
initial concentration: NaN
has only substance units: false
initial amount: NaN
constant: false
is: SBO:0000252
is: B3KQH0
boundary condition: true
is encoded by: hsa:55343
type: Species
name: SLC35C1

metaM ppi c
initial concentration: 1.0
notes: FORMULA: HO7P2 CHARGE: -3
type: Species
constant: false
is: SBO:0000247
initial amount: NaN
name: Diphosphate
is: C00013
boundary condition: false
is: HMDB00250
has only substance units: false
is: CHEBI:0

http://identifiers.org/biomodels.db/MODEL1310110042#_a71ef95c_bcac_4adb_83e0_e867322c0a74
is encoded by: hsa:93183
is: Q9H3S5
constant: false
initial amount: NaN
type: Species
has only substance units: false
boundary condition: true
initial concentration: NaN
name: PIGM
is: SBO:0000252

metaM dmnoncoa c
initial amount: NaN
notes: FORMULA: C32H54N7O17P3S CHARGE: -4 INCHI: InChI=1/C32H56N7O17P3S/c1-19(2)7-6-8-20(3)9-10-23(41)60-14-13-34-22(40)11-12-35-30(44)27(43)32(4,5)16-53-59(50,51)56-58(48,49)52-15-21-26(55-57(45,46)47)25(42)31(54-21)39-18-38-24-28(33)36-17-37-29(24)39/h17-21,25-27,31,42-43H,6-16H2,1-5H3,(H,34,40)(H,35,44)(H,48,49)(H,50,51)(H2,33,36,37)(H2,45,46,47)/t20?,21-,25-,26-,27?,31-/m1/s1
initial concentration: 1.0
constant: false
has only substance units: false
type: Species
is: SBO:0000247
is: HMDB11604
boundary condition: false
name: 4,8 dimethylnonanoyl-CoA

http://identifiers.org/biomodels.db/MODEL1310110042#_c2b334d9_d43a_4971_baee_2bda51aa6ff4
constant: false
name: TBXAS1
is encoded by: hsa:6916
has only substance units: false
is: SBO:0000252
boundary condition: true
initial amount: NaN
initial concentration: NaN
is: Q53F23
type: Species

http://identifiers.org/biomodels.db/MODEL1310110042#_b68f8c1a_76bc_4d2d_bdea_2e9f595dfdec
boundary condition: true
constant: false
initial concentration: NaN
type: Species
has only substance units: false
is encoded by: hsa:4705
is: SBO:0000252
initial amount: NaN
name: NDUFA10
is: O95299

metaM triodthy c
type: Species
boundary condition: false
has only substance units: false
is: HMDB00265
is: CHEBI:18258
initial concentration: 1.0
constant: false
notes: FORMULA: C15H12I3NO4 CHARGE: 0 INCHI: InChI=1S/C15H12I3NO4/c16-9-6-8(1-2-13(9)20)23-14-10(17)3-7(4-11(14)18)5-12(19)15(21)22/h1-4,6,12,20H,5,19H2,(H,21,22)/t12-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00943 EHMN_ABBREVIATION: C02465
initial amount: NaN
name: 3,3',5-triiodo-L-thyronine
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110042#_360eb212_8f6b_4cf8_a9f2_7c5f84b47510
type: Species
is: SBO:0000252
name: PEMT
initial concentration: NaN
constant: false
has only substance units: false
is encoded by: hsa:10400
initial amount: NaN
boundary condition: true

metaR ALCD2yf
reversible: false
notes: GENE_ASSOCIATION: (10327.1) or (10327.2) SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: 1.1.1.2 Confidence Level: 0 AUTHORS: PMID:11003211,PMID:14576493,PMID:19382904,PMID:19382905 NOTES:NCD
modifier: MODEL1310110042#
reactant: MODEL1310110042#
kinetic law: MODEL1310110042#
fast: false
is described by: ECO:0000134
is version of: http://identifiers.org/ec-code/1.1.1.2
type: Reaction
name: alcohol dehydrogenase (ethanol, NADP), forward reaction
is: SBO:0000176
product: MODEL1310110042#

metaM tdchola c
is: SBO:0000247
is: CHEBI:9407
is: HMDB00951
boundary condition: false
notes: FORMULA: C26H45NO6S CHARGE: 0 INCHI: InChI=1S/C26H45NO6S/c1-16(4-7-23(30)27-12-13-34(31,32)33)19-5-6-20-24-21(9-11-26(19,20)3)25(2)10-8-18(28)14-17(25)15-22(24)29/h16-22,24,28-29H,4-15H2,1-3H3,(H,27,30)(H,31,32,33)/p-1/t16-,17+,18-,19-,20+,21+,22-,24+,25+,26-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01471 EHMN_ABBREVIATION: C05465
constant: false
type: Species
has only substance units: false
name: taurochenodeoxycholate
initial amount: NaN
initial concentration: 1.0

metaR C12DCACOT
kinetic law: MODEL1310110042#
product: MODEL1310110042#
reactant: MODEL1310110042#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: thioesterification of dodecanedioyl coa for release into cytosol
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110042#_b0e1a4d0_d1d2_451f_9c88_f474fb4718c1
initial concentration: NaN
constant: false
is encoded by: hsa:515
boundary condition: true
has only substance units: false
initial amount: NaN
is: Q08ET0
is: SBO:0000252
type: Species
name: ATP5F1

metaM lgnccoa x
initial concentration: 1.0
notes: FORMULA: C45H78N7O17P3S CHARGE: -4 INCHI: InChI=1/C45H82N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-24-25-36(54)73-29-28-47-35(53)26-27-48-43(57)40(56)45(2,3)31-66-72(63,64)69-71(61,62)65-30-34-39(68-70(58,59)60)38(55)44(67-34)52-33-51-37-41(46)49-32-50-42(37)52/h32-34,38-40,44,55-56H,4-31H2,1-3H3,(H,47,53)(H,48,57)(H,61,62)(H,63,64)(H2,46,49,50)(H2,58,59,60)/t34-,38?,39-,40+,44-/m1/s1
is: SBO:0000247
is: HMDB06526
name: lignocericyl coenzyme A
boundary condition: false
initial amount: NaN
constant: false
has only substance units: false
type: Species

metaR LNLCCPT2
is: SBO:0000176
notes: GENE_ASSOCIATION: (1376.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: NOTES:NJ
type: Reaction
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/2.3.1.21
product: MODEL1310110042#
reversible: false
name: carnitine transferase
modifier: MODEL1310110042#
kinetic law: MODEL1310110042#
fast: false
reactant: MODEL1310110042#

metaM 3hbcoa m
notes: FORMULA: C25H38N7O18P3S CHARGE: -4 INCHI: InChI=1S/C25H42N7O18P3S/c1-13(33)8-16(35)54-7-6-27-15(34)4-5-28-23(38)20(37)25(2,3)10-47-53(44,45)50-52(42,43)46-9-14-19(49-51(39,40)41)18(36)24(48-14)32-12-31-17-21(26)29-11-30-22(17)32/h11-14,18-20,24,33,36-37H,4-10H2,1-3H3,(H,27,34)(H,28,38)(H,42,43)(H,44,45)(H2,26,29,30)(H2,39,40,41)/p-4/t13-,14+,18+,19+,20-,24+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00686 EHMN_ABBREVIATION: C01144
is: HMDB01166
is: SBO:0000247
constant: false
initial amount: NaN
boundary condition: false
has only substance units: false
name: (S)-3-hydroxybutanoyl-CoA(4-)
type: Species
initial concentration: 1.0
is: CHEBI:57316

metaM gdpfuc c
constant: false
has only substance units: false
is: CHEBI:57984
is: HMDB01095
initial amount: NaN
boundary condition: false
name: GDP-L-fucose(2-)
notes: FORMULA: C16H23N5O15P2 CHARGE: -2 INCHI: InChI=1S/C16H25N5O15P2/c1-4-7(22)9(24)11(26)15(33-4)35-38(30,31)36-37(28,29)32-2-5-8(23)10(25)14(34-5)21-3-18-6-12(21)19-16(17)20-13(6)27/h3-5,7-11,14-15,22-26H,2H2,1H3,(H,28,29)(H,30,31)(H3,17,19,20,27)/p-2/t4-,5+,7+,8+,9+,10+,11-,14+,15?/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00275 EHMN_ABBREVIATION: C00325
type: Species
initial concentration: 1.0
is: SBO:0000247

metaM pi g
boundary condition: false
has only substance units: false
type: Species
is: HMDB00973
is: SBO:0000247
notes: FORMULA: HO4P CHARGE: -2 INCHI: InChI=1S/H3O4P/c1-5(2,3)4/h(H3,1,2,3,4)/p-2 HEPATONET_1.0_ABBREVIATION: HC00019 EHMN_ABBREVIATION: C00009
name: hydrogenphosphate
is: CHEBI:43474
constant: false
initial concentration: 1.0
initial amount: NaN

metaM xylu L c
is: HMDB00751
initial amount: NaN
constant: false
has only substance units: false
initial concentration: 1.0
notes: FORMULA: C5H10O5 CHARGE: 0 INCHI: InChI=1S/C5H10O5/c6-1-3(8)5(10)4(9)2-7/h3,5-8,10H,1-2H2/t3-,5+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00267
is: SBO:0000247
type: Species
is: CHEBI:17399
boundary condition: false
name: L-xylulose

metaR SBT Dtde
reversible: true
is: SBO:0000185
is described by: ECO:0000134
type: Reaction
product: MODEL1310110042#
reactant: MODEL1310110042#
kinetic law: MODEL1310110042#
fast: false
name: D-sorbitol transport, extracellular
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: added during gap-filling. Diffusion into the blood is assumed. NOTES:added during gap-filling. Diffusion into the blood is assumed.

metaR DCMPDA
is described by: ECO:0000254
is version of: http://identifiers.org/ec-code/3.5.4.12
kinetic law: MODEL1310110042#
fast: false
notes: GENE_ASSOCIATION: (1635.1) SUBSYSTEM: Pyrimidine catabolism EC Number: 3.5.4.12 Confidence Level: 2 AUTHORS: PMID:7642519,PMID:7685356 NOTES:NCD
reactant: MODEL1310110042#
is: SBO:0000176
product: MODEL1310110042#
name: dCMP deaminase
reversible: true
modifier: MODEL1310110042#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110042#_295fb51b_8bde_4cde_a9c6_62aed7846b9d
is: P51648
type: Species
is encoded by: hsa:224
initial amount: NaN
has only substance units: false
initial concentration: NaN
name: ALDH3A2
boundary condition: true
is: SBO:0000252
constant: false

metaM 7dhf e
boundary condition: false
is: HMDB06559
name: heptaglutamyl folate (DHF)
constant: false
is: SBO:0000247
type: Species
initial concentration: 1.0
notes: FORMULA: C49H55N13O24 CHARGE: -8 INCHI: InChI=1/C54H68N14O27/c55-24(5-12-31(69)70)39(83)52(49(92)93,40(84)25(56)6-13-32(71)72)53(41(85)26(57)7-14-33(73)74,42(86)27(58)8-15-34(75)76)54(43(87)28(59)9-16-35(77)78,50(94)95-48(91)30(61)11-18-37(81)82)68(47(90)29(60)10-17-36(79)80)46(89)21-1-3-22(4-2-21)63-19-23-20-64-44-38(65-23)45(88)67-51(62)66-44/h1-4,20,24-30,63H,5-19,55-61H2,(H,69,70)(H,71,72)(H,73,74)(H,75,76)(H,77,78)(H,79,80)(H,81,82)(H,92,93)(H3,62,64,66,67,88)/t24-,25-,26-,27-,28-,29-,30-,54?/m0/s1
initial amount: NaN
has only substance units: false

metaR EX aicar LPAREN e RPAREN
kinetic law: MODEL1310110042#
reactant: MODEL1310110042#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: Exchange of 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide(2-)
type: Reaction

metaR ARSA
reactant: MODEL1310110042#
modifier: MODEL1310110042#
notes: GENE_ASSOCIATION: (410.1) SUBSYSTEM: Sphingolipid metabolism EC Number: 3.1.6.8 Confidence Level: 4 AUTHORS: PMID:2562955 NOTES:NJ
is version of: http://identifiers.org/ec-code/3.1.6.8
is described by: ECO:0000000
is: SBO:0000176
name: Arylsulfatase A
type: Reaction
fast: false
product: MODEL1310110042#
reversible: false
kinetic law: MODEL1310110042#

http://identifiers.org/biomodels.db/MODEL1310110042#_b474a34e_84d8_4677_82d8_217b532af4df
constant: false
type: Species
is encoded by: hsa:5143
boundary condition: true
is: Q7KYS4
is: SBO:0000252
name: PDE4C
initial concentration: NaN
initial amount: NaN
has only substance units: false

metaM ksi deg8 l
has only substance units: false
constant: false
is: CHEBI:12936
boundary condition: false
initial concentration: 1.0
name: keratan sulfate I, degradation product 8
initial amount: NaN
notes: FORMULA: C194H311N13O171S10 CHARGE: -10
type: Species
is: SBO:0000247
is: HMDB00143

metaR r2443
is described by: ECO:0000000
is: SBO:0000185
reversible: false
fast: false
product: MODEL1310110042#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
name: Proposed Fatty Acid Transporter (FAT) TCDB:4.C.1.1.5
reactant: MODEL1310110042#
type: Reaction
kinetic law: MODEL1310110042#

http://identifiers.org/biomodels.db/MODEL1310110042#_88c959b2_c972_4531_90bb_ca0221c51698
type: Species
is: Q9BYZ2
initial amount: NaN
name: LDHAL6B
constant: false
initial concentration: NaN
has only substance units: false
boundary condition: true
is: SBO:0000252
is encoded by: hsa:92483

metaR EX 3tdcrn
kinetic law: MODEL1310110042#
reactant: MODEL1310110042#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for 3-hydroxy-tetradecanoyl carnitine
type: Reaction

metaM 35cgmp e
initial concentration: 1.0
boundary condition: false
constant: false
initial amount: NaN
name: 3',5'-cyclic GMP(1-)
has only substance units: false
is: HMDB01314
is: SBO:0000247
type: Species
notes: FORMULA: C10H11N5O7P CHARGE: -1 INCHI: InChI=1S/C10H12N5O7P/c11-10-13-7-4(8(17)14-10)12-2-15(7)9-5(16)6-3(21-9)1-20-23(18,19)22-6/h2-3,5-6,9,16H,1H2,(H,18,19)(H3,11,13,14,17)/p-1/t3-,5-,6-,9-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00592 EHMN_ABBREVIATION: C00942
is: CHEBI:57746

http://identifiers.org/biomodels.db/MODEL1310110042#_aeb785c3_5cb7_489a_bb5e_b163f8dcb767
initial amount: NaN
name: HPRT1
constant: false
is: SBO:0000252
type: Species
is: P00492
boundary condition: true
is encoded by: hsa:3251
has only substance units: false
initial concentration: NaN

metaR EX pect LPAREN e RPAREN
kinetic law: MODEL1310110042#
reactant: MODEL1310110042#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for pectins
type: Reaction

metaM HC01162 c
name: (2R,4S,5R,6R)-2-[({[(2R,3S,4R,5R)-5-(4-amino-2-oxo-1,2-dihydropyrimidin-1-yl)-3,4-dihydroxyoxolan-2-yl]methoxy}phosphinato)oxy]-4-hydroxy-5-(2-hydroxyacetamido)-6-[(1R,2R)-1,2,3-trihydroxypropyl]oxane-2-carboxylate
is: CHEBI:58376
boundary condition: false
initial concentration: 1.0
has only substance units: false
constant: false
type: Species
initial amount: NaN
notes: FORMULA: C20H29N4O17P CHARGE: -2 INCHI: InChI=1S/C20H31N4O17P/c21-10-1-2-24(19(35)22-10)17-15(32)14(31)9(39-17)6-38-42(36,37)41-20(18(33)34)3-7(27)12(23-11(29)5-26)16(40-20)13(30)8(28)4-25/h1-2,7-9,12-17,25-28,30-32H,3-6H2,(H,23,29)(H,33,34)(H,36,37)(H2,21,22,35)/p-2/t7-,8+,9+,12+,13+,14+,15+,16+,17+,20+/m0/s1 EHMN_ABBREVIATION: C03691
is: SBO:0000247

metaM mi14p c
notes: FORMULA: C6H10O12P2 CHARGE: -4 INCHI: InChI=1S/C6H14O12P2/c7-1-2(8)6(18-20(14,15)16)4(10)3(9)5(1)17-19(11,12)13/h1-10H,(H2,11,12,13)(H2,14,15,16)/p-4/t1-,2-,3-,4+,5+,6+/m1/s1 EHMN_ABBREVIATION: C01220
name: (1R,2R,3R,4R,5R,6S)-2,3,5,6-tetrahydroxy-4-(phosphonatooxy)cyclohexyl phosphate
type: Species
is: HMDB00968
initial amount: NaN
is: SBO:0000247
is: CHEBI:58282
initial concentration: 1.0
constant: false
boundary condition: false
has only substance units: false

metaR GLYt7 311 r
product: MODEL1310110042#
name: glycine reversible transport via sodium and chloride symport (3:1:1)
is: SBO:0000185
reversible: true
type: Reaction
reactant: MODEL1310110042#
kinetic law: MODEL1310110042#
notes: GENE_ASSOCIATION: (9152.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12719981 NOTES:SAB
modifier: MODEL1310110042#
fast: false
is described by: ECO:0000006

metaM nrvnccoa x
initial concentration: 1.0
boundary condition: false
has only substance units: false
is: C16532
constant: false
notes: FORMULA: C45H76N7O17P3S CHARGE: -4 INCHI: InChI=1/C45H80N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-24-25-36(54)73-29-28-47-35(53)26-27-48-43(57)40(56)45(2,3)31-66-72(63,64)69-71(61,62)65-30-34-39(68-70(58,59)60)38(55)44(67-34)52-33-51-37-41(46)49-32-50-42(37)52/h11-12,32-34,38-40,44,55-56H,4-10,13-31H2,1-3H3,(H,47,53)(H,48,57)(H,61,62)(H,63,64)(H2,46,49,50)(H2,58,59,60)/b12-11-/t34-,38-,39-,40?,44-/m1/s1
name: nervonyl coenzyme A
initial amount: NaN
type: Species
is: SBO:0000247

metaR SPRMS
type: Reaction
fast: false
reactant: MODEL1310110042#
is: SBO:0000176
kinetic law: MODEL1310110042#
product: MODEL1310110042#
notes: GENE_ASSOCIATION: (6611.1) SUBSYSTEM: Urea cycle EC Number: 2.5.1.22 Confidence Level: 4 AUTHORS: PMID:7546290 NOTES:NCD
name: spermine synthase
is version of: http://identifiers.org/ec-code/2.5.1.22
reversible: false
is described by: ECO:0000269
modifier: MODEL1310110042#

metaM cspg b e
is: CHEBI:16040
name: chondroitin sulfate B / dermatan sulfate (IdoA2S-GalNAc4S) proteoglycan
notes: FORMULA: C45H65N2O48S4X CHARGE: -6
initial concentration: 1.0
type: Species
is: SBO:0000247
initial amount: NaN
is: HMDB00630
has only substance units: false
boundary condition: false
constant: false

metaM xyl D c
notes: FORMULA: C5H10O5 CHARGE: 0 INCHI: InChI=1S/C5H10O5/c6-1-3(8)5(10)4(9)2-7/h1,3-5,7-10H,2H2/t3-,4+,5+/m0/s1
boundary condition: false
is: SBO:0000247
has only substance units: false
type: Species
name: aldehydo-D-xylose
constant: false
is: CHEBI:15936
initial amount: NaN
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110042#_e37dc26a_2844_465b_ae1b_a88c51d799cc
is: SBO:0000252
is: Q9Y345
constant: false
initial amount: NaN
boundary condition: true
is encoded by: hsa:9152
type: Species
name: SLC6A5
has only substance units: false
initial concentration: NaN

metaR LCTStg
is described by: ECO:0000000
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:this reaciton is only found in lactating mammary cells NCD
name: lactose transport from Golgi to extracellular (via vesicle)
kinetic law: MODEL1310110042#
reactant: MODEL1310110042#
type: Reaction
reversible: false
product: MODEL1310110042#
fast: false

metaM pi n
notes: FORMULA: HO4P CHARGE: -2 INCHI: InChI=1S/H3O4P/c1-5(2,3)4/h(H3,1,2,3,4)/p-2 HEPATONET_1.0_ABBREVIATION: HC00019 EHMN_ABBREVIATION: C00009
has only substance units: false
initial concentration: 1.0
is: SBO:0000247
constant: false
initial amount: NaN
is: HMDB00973
boundary condition: false
is: CHEBI:43474
type: Species
name: hydrogenphosphate

metaR HOXG
kinetic law: MODEL1310110042#
product: MODEL1310110042#
reactant: MODEL1310110042#
fast: false
notes: GENE_ASSOCIATION: (3162.1) or (3163.1) SUBSYSTEM: Heme degradation EC Number: 1.14.99.3 Confidence Level: 0 AUTHORS: PMID:16356137 NOTES:TDV (4/28/2004) There are conflicting data on how many moles of NADPH consumed per mole of Biliverdine (Tenhunen 1969, Ryter, 2000). Heme oxygenase is a well known enzyme
is version of: http://identifiers.org/ec-code/1.14.99.3
name: Heme oxygenase 1
type: Reaction
modifier: MODEL1310110042#
is described by: ECO:0000134
is: SBO:0000176
reversible: false

metaR HOCDACBP
kinetic law: MODEL1310110042#
product: MODEL1310110042#
reactant: MODEL1310110042#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: transport of (S)-3-Hydroxyoctadecanoyl-CoA from mitochondria into the cytosol
type: Reaction

metaM glyb c
has only substance units: false
name: glycine betaine
boundary condition: false
type: Species
is: SBO:0000247
constant: false
initial amount: NaN
is: CHEBI:17750
notes: FORMULA: C5H11NO2 CHARGE: 0 INCHI: InChI=1S/C5H11NO2/c1-6(2,3)4-5(7)8/h4H2,1-3H3 HEPATONET_1.0_ABBREVIATION: HC00515 EHMN_ABBREVIATION: C00719
is: HMDB00043
initial concentration: 1.0

metaR PROSTGD2t
is described by: ECO:0000269
reversible: true
name: prostaglandin transport via bicarbonate countertransport
type: Reaction
product: MODEL1310110042#
fast: false
kinetic law: MODEL1310110042#
notes: GENE_ASSOCIATION: (6578.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12507753,PMID:8787677,PMID:9334206 NOTES:NJ
is: SBO:0000185
modifier: MODEL1310110042#
reactant: MODEL1310110042#

metaM crn r
name: (R)-carnitine
type: Species
is: HMDB00062
is: CHEBI:16347
boundary condition: false
is: SBO:0000247
constant: false
initial amount: NaN
initial concentration: 1.0
notes: FORMULA: C7H15NO3 CHARGE: 0 INCHI: InChI=1S/C7H15NO3/c1-8(2,3)5-6(9)4-7(10)11/h6,9H,4-5H2,1-3H3/t6-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00270 EHMN_ABBREVIATION: C00318
has only substance units: false

metaR S6T3g
type: Reaction
fast: false
reversible: false
modifier: MODEL1310110042#
reactant: MODEL1310110042#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.8.2.21
name: galactose/N-acetylglucosamine 6-O-sulfotransferase, Golgi apparatus
is version of: http://identifiers.org/ec-code/2.8.2.17
product: MODEL1310110042#
kinetic law: MODEL1310110042#
notes: GENE_ASSOCIATION: (8534.1) or (9469.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: Confidence Level: 4 AUTHORS: PMID:12403612,PMID:8991509,PMID:9405439,PMID:9714738 NOTES:NCD
is described by: ECO:0000000

metaR ACGAMPM
type: Reaction
notes: GENE_ASSOCIATION: (5238.1) SUBSYSTEM: Aminosugar metabolism EC Number: 5.4.2.3 Confidence Level: 4 AUTHORS: PMID:11004509 NOTES:NCD
name: phosphoacetylglucosamine mutase
is described by: ECO:0000269
reactant: MODEL1310110042#
fast: false
is version of: http://identifiers.org/ec-code/5.4.2.3
product: MODEL1310110042#
reversible: true
modifier: MODEL1310110042#
is: SBO:0000176
kinetic law: MODEL1310110042#

http://identifiers.org/biomodels.db/MODEL1310110042#_35d14da0_1e4f_4136_bab8_4f94e244a5e3
is encoded by: hsa:3098
constant: false
name: HK1
initial amount: NaN
is: P19367
is: SBO:0000252
type: Species
has only substance units: false
initial concentration: NaN
boundary condition: true

metaR 3MOX4HOXPGALDOX NADP
modifier: MODEL1310110042#
fast: false
notes: GENE_ASSOCIATION: (222.1) or (220.1) or (221.1) or (218.1) SUBSYSTEM: Tyrosine metabolism EC Number: 1.2.1.5 Confidence Level: 2 AUTHORS: NOTES:SAB
kinetic law: MODEL1310110042#
is described by: ECO:0000304
is: SBO:0000176
type: Reaction
reversible: true
is version of: http://identifiers.org/ec-code/1.2.1.5
name: 3-Methoxy-4-hydroxyphenylglycolaldehyde:NADP+ oxidoreductase
product: MODEL1310110042#
reactant: MODEL1310110042#

http://identifiers.org/biomodels.db/MODEL1310110042#_fe00ad39_193e_429c_8575_82f0bb482afe
is: SBO:0000252
boundary condition: true
has only substance units: false
is: Q9UNP4
name: ST3GAL5
constant: false
type: Species
initial concentration: NaN
is encoded by: hsa:8869
initial amount: NaN

metaR ELAIDCPT1
product: MODEL1310110042#
modifier: MODEL1310110042#
name: carnitine O-palmitoyltransferase
notes: GENE_ASSOCIATION: (1375.1) or (1375.3) or (1375.4) or (126129.1) or (1374.1) or (1375.2) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.21 Confidence Level: 4 AUTHORS: NOTES:NJ
is described by: ECO:0000269
kinetic law: MODEL1310110042#
type: Reaction
fast: false
reactant: MODEL1310110042#
reversible: false
is version of: http://identifiers.org/ec-code/2.3.1.21
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110042#_ddc0c0dc_18ed_4f82_b10c_95a37110a6ea
initial amount: NaN
constant: false
has only substance units: false
name: B3GALNT1
initial concentration: NaN
is: Q49AT3
type: Species
boundary condition: true
is: SBO:0000252
is encoded by: hsa:8706

http://identifiers.org/biomodels.db/MODEL1310110042#_f6b2858f_ebdd_48a0_a761_93e5b6b4393c
name: CMPK1
boundary condition: true
initial amount: NaN
has only substance units: false
is: SBO:0000252
is: B2R6S5
constant: false
is encoded by: hsa:51727
type: Species
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110042#_b191428a_3cc6_460c_9f50_7afd7e591939
name: ADSS
type: Species
is: P30520
has only substance units: false
is: SBO:0000252
boundary condition: true
initial amount: NaN
constant: false
is encoded by: hsa:159
initial concentration: NaN

metaR MTHFD
name: methylenetetrahydrofolate dehydrogenase (NADP)
fast: false
reversible: true
is version of: http://identifiers.org/ec-code/1.5.1.5
is: SBO:0000176
notes: GENE_ASSOCIATION: (4522.1) SUBSYSTEM: Folate metabolism EC Number: 1.5.1.5 Confidence Level: 4 AUTHORS: PMID:2786332 NOTES:Human Y/N: Y
kinetic law: MODEL1310110042#
modifier: MODEL1310110042#
is described by: ECO:0000134
product: MODEL1310110042#
type: Reaction
reactant: MODEL1310110042#

metaM pi m
name: hydrogenphosphate
is: C00009
is: SBO:0000247
notes: FORMULA: HO4P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00019 EHMN_ABBREVIATION: C00009
is: CHEBI:43474
initial concentration: 1.0
initial amount: NaN
constant: false
has only substance units: false
boundary condition: false
type: Species
is: HMDB00973

http://identifiers.org/biomodels.db/MODEL1310110042#_3382df39_3374_405d_8f4f_c36fe8e98ce8
constant: false
is: SBO:0000252
is: Q6ZMR3
has only substance units: false
is encoded by: hsa:160287
initial concentration: NaN
initial amount: NaN
name: LDHAL6A
type: Species
boundary condition: true

metaM cpppg3 c
constant: false
is: SBO:0000247
has only substance units: false
is: CHEBI:57309
initial amount: NaN
initial concentration: 1.0
is: HMDB01261
type: Species
boundary condition: false
is: C03263
notes: FORMULA: C36H40N4O8 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC01085 EHMN_ABBREVIATION: C03263
name: Coproporphyrinogen III

metaM hexdpencoa x
initial amount: NaN
name: 2,4,7,10,13-hexadecapentaenoylcoa
type: Species
initial concentration: 1.0
is: SBO:0000247
is: HMDB02288
has only substance units: false
boundary condition: false
constant: false
notes: FORMULA: C37H52N7O17P3S CHARGE: -4

metaR S6TASE16ly
notes: GENE_ASSOCIATION: (2799.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.1.6.14 Confidence Level: 4 AUTHORS: PMID:3196333,PMID:3689314,PMID:3689315 NOTES:NCD
is described by: ECO:0000000
fast: false
product: MODEL1310110042#
type: Reaction
is: SBO:0000176
reactant: MODEL1310110042#
modifier: MODEL1310110042#
kinetic law: MODEL1310110042#
reversible: true
name: N-acetylglucosamine-6-sulfatase, lysosomal
is version of: http://identifiers.org/ec-code/3.1.6.14

http://identifiers.org/biomodels.db/MODEL1310110042#_9e19bf4b_4afb_4c6a_9129_f2cda505d634
name: _BE966236_1_c
has only substance units: false
is: SBO:0000252
initial concentration: NaN
is encoded by: hsa:BE966236
boundary condition: true
type: Species
initial amount: NaN
constant: false

metaM 35cgmp c
name: 3',5'-cyclic GMP(1-)
initial concentration: 1.0
is: HMDB01314
type: Species
is: SBO:0000247
initial amount: NaN
boundary condition: false
is: CHEBI:57746
has only substance units: false
notes: FORMULA: C10H11N5O7P CHARGE: -1 INCHI: InChI=1S/C10H12N5O7P/c11-10-13-7-4(8(17)14-10)12-2-15(7)9-5(16)6-3(21-9)1-20-23(18,19)22-6/h2-3,5-6,9,16H,1H2,(H,18,19)(H3,11,13,14,17)/p-1/t3-,5-,6-,9-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00592 EHMN_ABBREVIATION: C00942
constant: false

metaR PGK
product: MODEL1310110042#
fast: false
is described by: ECO:0000134
reversible: true
modifier: MODEL1310110042#
type: Reaction
reactant: MODEL1310110042#
kinetic law: MODEL1310110042#
is: SBO:0000176
notes: GENE_ASSOCIATION: (5230.1) or (375056.1) or (5232.1) SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: Confidence Level: 0 AUTHORS: NOTES:
name: phosphoglycerate kinase
is version of: http://identifiers.org/ec-code/2.7.2.3

http://identifiers.org/biomodels.db/MODEL1310110042#_1be5716c_4a92_49c0_9ad4_86244a4e5bb1
constant: false
has only substance units: false
is: SBO:0000252
is: P47989
boundary condition: true
type: Species
is encoded by: hsa:7498
name: XDH
initial amount: NaN
initial concentration: NaN

metaR ELAIDCPT2
reversible: false
modifier: MODEL1310110042#
is version of: http://identifiers.org/ec-code/2.3.1.21
is described by: ECO:0000000
name: carnitine transferase
product: MODEL1310110042#
type: Reaction
notes: GENE_ASSOCIATION: (1376.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: NOTES:NJ
is: SBO:0000176
kinetic law: MODEL1310110042#
reactant: MODEL1310110042#
fast: false

http://identifiers.org/biomodels.db/MODEL1310110042#_bcaf7d77_2df1_4c6a_81d9_46d21ae923f8
type: Species
boundary condition: true
constant: false
name: _AI378339_1_m
is encoded by: hsa:AI378339
is: SBO:0000252
initial concentration: NaN
initial amount: NaN
has only substance units: false

metaM ksi deg10 l
is: SBO:0000247
boundary condition: false
initial amount: NaN
notes: FORMULA: C188H302N13O163S9 CHARGE: -9
constant: false
type: Species
is: HMDB00812
has only substance units: false
initial concentration: 1.0
is: CHEBI:16953
name: keratan sulfate I, degradation product 10

metaR CYTK4n
type: Reaction
is: SBO:0000176
is described by: ECO:0000269
kinetic law: MODEL1310110042#
reversible: true
reactant: MODEL1310110042#
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
fast: false
product: MODEL1310110042#
modifier: MODEL1310110042#
is version of: http://identifiers.org/ec-code/2.7.4.14
name: cytidylate kinase (dCMP,GTP),nuclear

metaM pi l
initial concentration: 1.0
is: SBO:0000247
boundary condition: false
constant: false
initial amount: NaN
is: HMDB00973
notes: FORMULA: HO4P CHARGE: -2 INCHI: InChI=1S/H3O4P/c1-5(2,3)4/h(H3,1,2,3,4)/p-2 HEPATONET_1.0_ABBREVIATION: HC00019 EHMN_ABBREVIATION: C00009
has only substance units: false
name: hydrogenphosphate
is: CHEBI:43474
type: Species

metaR RE1447M
notes: GENE_ASSOCIATION: (54995.1) SUBSYSTEM: Phosphatidylinositol phosphate metabolism EC Number: 3.1.3.66 Confidence Level: 0 AUTHORS: PMID:11756679,PMID:7556092,PMID:7567999,PMID:9295334,PMID:9356448 NOTES:
is: SBO:0000176
reactant: MODEL1310110042#
product: MODEL1310110042#
reversible: true
name: RE1447
modifier: MODEL1310110042#
fast: false
is version of: http://identifiers.org/ec-code/2.3.1.41
kinetic law: MODEL1310110042#
is described by: ECO:0000000
type: Reaction

metaR MTHFC
reactant: MODEL1310110042#
kinetic law: MODEL1310110042#
fast: false
modifier: MODEL1310110042#
product: MODEL1310110042#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.5.4.9
is version of: http://identifiers.org/ec-code/1.5.1.5
reversible: true
name: methenyltetrahydrofolate cyclohydrolase
type: Reaction
is described by: ECO:0000134
notes: GENE_ASSOCIATION: (4522.1) or (100287639.1) or (441024.1) SUBSYSTEM: Folate metabolism EC Number: 3.5.4.9 Confidence Level: 4 AUTHORS: PMID:2786332 NOTES:Human Y/N: Y

metaM CE2917 e
constant: false
has only substance units: false
type: Species
notes: FORMULA: C69H114N23O16S CHARGE: 3 INCHI: InChI=1/C69H111N23O16S/c1-39(2)32-47(86-58(98)44(17-9-26-78-68(73)74)83-63(103)52-20-12-29-91(52)65(105)45(18-10-27-79-69(75)76)84-56(96)42(71)22-23-54(72)94)59(99)89-50(37-93)61(101)87-48(34-41-35-77-38-81-41)60(100)82-43(16-7-8-25-70)57(97)80-36-55(95)90-28-11-19-51(90)62(102)85-46(24-31-109-3)66(106)92-30-13-21-53(92)64(104)88-49(67(107)108)33-40-14-5-4-6-15-40/h4-6,14-15,35,38-39,42-53,93H,7-13,16-34,36-37,70-71H2,1-3H3,(H2,72,94)(H,77,81)(H,80,97)(H,82,100)(H,83,103)(H,84,96)(H,85,102)(H,86,98)(H,87,101)(H,88,104)(H,89,99)(H,107,108)(H4,73,74,78)(H4,75,76,79)/p+3/t42-,43-,44-,45+,46-,47+,48+,49+,50-,51+,52+,53-/m1/s1 EHMN_ABBREVIATION: CE2917
is: C01936
name: apelin-13
initial amount: NaN
is: SBO:0000247
is: http://identifiers.org/pubchem.compound/5041
boundary condition: false
initial concentration: 1.0

metaR FAOXC8C6x
kinetic law: MODEL1310110042#
product: MODEL1310110042#
reactant: MODEL1310110042#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C8-->C6)x
type: Reaction

metaR EX 5dhf LPAREN e RPAREN
kinetic law: MODEL1310110042#
reactant: MODEL1310110042#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: pentaglutamyl folate (DHF) exchange
type: Reaction

metaR FAOXC164m
kinetic law: MODEL1310110042#
product: MODEL1310110042#
reactant: MODEL1310110042#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: isomerization(C16:4)m
type: Reaction

metaM glyb e
initial concentration: 1.0
has only substance units: false
is: SBO:0000247
constant: false
type: Species
name: glycine betaine
boundary condition: false
initial amount: NaN
is: CHEBI:17750
is: HMDB00043
notes: FORMULA: C5H11NO2 CHARGE: 0 INCHI: InChI=1S/C5H11NO2/c1-6(2,3)4-5(7)8/h4H2,1-3H3 HEPATONET_1.0_ABBREVIATION: HC00515 EHMN_ABBREVIATION: C00719

metaM ac e
notes: FORMULA: C2H3O2 CHARGE: -1 INCHI: InChI=1S/C2H4O2/c1-2(3)4/h1H3,(H,3,4)/p-1 HEPATONET_1.0_ABBREVIATION: HC00042 EHMN_ABBREVIATION: C00033
is: CHEBI:30089
initial amount: NaN
has only substance units: false
is: HMDB00042
type: Species
boundary condition: false
is: SBO:0000247
initial concentration: 1.0
name: acetate
constant: false

metaR ORNTArm
modifier: MODEL1310110042#
kinetic law: MODEL1310110042#
is: SBO:0000176
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (4942.1) SUBSYSTEM: Urea cycle EC Number: 2.6.1.13 Confidence Level: 4 AUTHORS: PMID:9514741 NOTES:kh 1/7/03 SAB m
product: MODEL1310110042#
reactant: MODEL1310110042#
reversible: true
name: ornithine transaminase reversible (m)
fast: false
is version of: http://identifiers.org/ec-code/2.6.1.13
type: Reaction

metaR PYK
fast: false
reversible: false
product: MODEL1310110042#
kinetic law: MODEL1310110042#
name: pyruvate kinase
is version of: http://identifiers.org/ec-code/2.7.1.40
modifier: MODEL1310110042#
reactant: MODEL1310110042#
notes: GENE_ASSOCIATION: (5315.2) or (5313.2) or (5315.3) or (5313.1) or (113452.1) or (5315.1) SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: Confidence Level: 0 AUTHORS: NOTES:
type: Reaction
is: SBO:0000176
is described by: ECO:0000134

metaM xol7ah2 c
is: HMDB06893
boundary condition: false
constant: false
has only substance units: false
name: 5beta-cholestane-3alpha,7alpha-diol
is: SBO:0000247
notes: FORMULA: C27H48O2 CHARGE: 0 INCHI: InChI=1S/C27H48O2/c1-17(2)7-6-8-18(3)21-9-10-22-25-23(12-14-27(21,22)5)26(4)13-11-20(28)15-19(26)16-24(25)29/h17-25,28-29H,6-16H2,1-5H3/t18-,19+,20-,21-,22+,23+,24-,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01461 EHMN_ABBREVIATION: C05452
initial amount: NaN
is: CHEBI:28047
type: Species
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110042#_0b4b3a59_5a83_4006_a15c_00b22646f9e8
type: Species
is: P48201
initial amount: NaN
boundary condition: true
is encoded by: hsa:518
name: ATP5G3
constant: false
initial concentration: NaN
is: SBO:0000252
has only substance units: false

metaR RE1447N
fast: false
product: MODEL1310110042#
is: SBO:0000176
name: RE1447
kinetic law: MODEL1310110042#
reversible: true
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Phosphatidylinositol phosphate metabolism EC Number: 3.1.3.66 Confidence Level: 0 AUTHORS: PMID:11756679,PMID:7556092,PMID:7567999,PMID:9295334,PMID:9356448 NOTES:
type: Reaction
reactant: MODEL1310110042#

http://identifiers.org/biomodels.db/MODEL1310110042#_120d2cc3_4973_4203_b485_243f359a7f7c
initial concentration: NaN
boundary condition: true
initial amount: NaN
is encoded by: hsa:54407
has only substance units: false
is: SBO:0000252
name: SLC38A2
constant: false
is: Q96QD8
type: Species

metaR CYSASNNaEx
is: SBO:0000185
is described by: ECO:0000269
type: Reaction
kinetic law: MODEL1310110042#
modifier: MODEL1310110042#
reactant: MODEL1310110042#
name: L-cysteine/L-asparagine Na-dependent exchange (Cys-L in)
product: MODEL1310110042#
reversible: false
notes: GENE_ASSOCIATION: (6510.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14530974 NOTES:SAB see Kanai and Hediger 2004 (2003), PMID 14530974
fast: false

metaR EX CE2838 LPAREN e RPAREN
kinetic law: MODEL1310110042#
reactant: MODEL1310110042#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: maltononaose exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110042#_3e618451_012e_4256_b263_c135259b4802
has only substance units: false
name: VNN2
is encoded by: hsa:8875
constant: false
is: O95498
type: Species
initial amount: NaN
initial concentration: NaN
boundary condition: true
is: SBO:0000252

metaM rbt c
is: SBO:0000247
has only substance units: false
is: HMDB00508
is: CHEBI:15963
boundary condition: false
initial concentration: 1.0
initial amount: NaN
type: Species
constant: false
notes: FORMULA: C5H12O5 CHARGE: 0 INCHI: InChI=1S/C5H12O5/c6-1-3(8)5(10)4(9)2-7/h3-10H,1-2H2/t3-,4+,5- HEPATONET_1.0_ABBREVIATION: HC00380
name: D-ribitol

metaM fadh2 c
boundary condition: false
name: FADH2(2-)
constant: false
initial concentration: 1.0
is: HMDB01197
type: Species
is: SBO:0000247
notes: FORMULA: C27H33N9O15P2 CHARGE: -2 INCHI: InChI=1S/C27H35N9O15P2/c1-10-3-12-13(4-11(10)2)35(24-18(32-12)25(42)34-27(43)33-24)5-14(37)19(39)15(38)6-48-52(44,45)51-53(46,47)49-7-16-20(40)21(41)26(50-16)36-9-31-17-22(28)29-8-30-23(17)36/h3-4,8-9,14-16,19-21,26,32,37-41H,5-7H2,1-2H3,(H,44,45)(H,46,47)(H2,28,29,30)(H2,33,34,42,43)/p-2/t14-,15+,16+,19-,20+,21+,26+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00770 EHMN_ABBREVIATION: C01352
has only substance units: false
initial amount: NaN
is: CHEBI:58307

metaR TSTSTERONESte
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 1 AUTHORS: NOTES:unknown mechanism - presumed excretion of sulfonated testosterone NJ
fast: false
reversible: true
is: SBO:0000185
kinetic law: MODEL1310110042#
product: MODEL1310110042#
reactant: MODEL1310110042#
type: Reaction
name: sulfonated testosterone transport
is described by: ECO:0000000

metaR S3TASE1ly
fast: false
name: N-acetylglucosamine-3-sulfatase, lysosomal
reversible: true
kinetic law: MODEL1310110042#
product: MODEL1310110042#
is described by: ECO:0000000
reactant: MODEL1310110042#
is: SBO:0000176
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Heparan sulfate degradation EC Number: 3.1.6.15 Confidence Level: 4 AUTHORS: PMID:7396957,PMID:8993162 NOTES:NCD

metaM ksi deg27 l
constant: false
name: keratan sulfate I, degradation product 27
is: HMDB00143
boundary condition: false
has only substance units: false
is: SBO:0000247
notes: FORMULA: C104H169N7O88S4 CHARGE: -4
initial concentration: 1.0
type: Species
is: CHEBI:12936
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110042#_b572eff9_23bb_445d_af67_0844366e4b8a
has only substance units: false
is: Q14435
constant: false
initial amount: NaN
is encoded by: hsa:2591
type: Species
is: SBO:0000252
initial concentration: NaN
name: GALNT3
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110042#_cace178c_75c4_45df_9f76_0fc614a9937e
has only substance units: false
type: Species
is encoded by: hsa:6513
boundary condition: true
initial amount: NaN
constant: false
is: P11166
initial concentration: NaN
name: SLC2A1
is: SBO:0000252

metaM glyald c
has only substance units: false
constant: false
is: SBO:0000247
initial amount: NaN
is: CHEBI:17378
initial concentration: 1.0
type: Species
notes: FORMULA: C3H6O3 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00436 EHMN_ABBREVIATION: C00577
is: C00577
boundary condition: false
name: D-Glyceraldehyde
is: HMDB01051

metaR r1446
reactant: MODEL1310110042#
product: MODEL1310110042#
kinetic law: MODEL1310110042#
is: SBO:0000176
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 1.3.3.6 Confidence Level: 0 AUTHORS: PMID:17603022,PMID:1774065,PMID:3597357,PMID:6240978,PMID:7876265 NOTES:
name: EC:1.3.3.6
type: Reaction
is described by: ECO:0000000
reversible: false

metaR C180CPT2
fast: false
is described by: ECO:0000269
modifier: MODEL1310110042#
type: Reaction
reversible: false
reactant: MODEL1310110042#
product: MODEL1310110042#
is: SBO:0000176
name: carnitine O-stearoyl transferase
kinetic law: MODEL1310110042#
is version of: http://identifiers.org/ec-code/2.3.1.21
notes: GENE_ASSOCIATION: (1376.1) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.21 Confidence Level: 4 AUTHORS: PMID:1528846,PMID:1988962 NOTES:TV

metaM lthstrl r
is: CHEBI:17168
boundary condition: false
initial amount: NaN
has only substance units: false
initial concentration: 1.0
is: SBO:0000247
notes: FORMULA: C27H46O CHARGE: 0 INCHI: InChI=1S/C27H46O/c1-18(2)7-6-8-19(3)23-11-12-24-22-10-9-20-17-21(28)13-15-26(20,4)25(22)14-16-27(23,24)5/h10,18-21,23-25,28H,6-9,11-17H2,1-5H3/t19-,20+,21+,23-,24+,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00706 EHMN_ABBREVIATION: C01189
constant: false
is: HMDB01170
type: Species
name: 5alpha-cholest-7-en-3beta-ol

http://identifiers.org/biomodels.db/MODEL1310110042#_088f060f_132c_4bc1_b0ee_25c99517c09d
boundary condition: true
name: CPT2
is encoded by: hsa:1376
initial concentration: NaN
is: P23786
initial amount: NaN
constant: false
has only substance units: false
is: SBO:0000252
type: Species

metaR FAOXC123C102m
kinetic law: MODEL1310110042#
product: MODEL1310110042#
reactant: MODEL1310110042#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C12:3-->C10:2)m
type: Reaction

metaR DOLPMT4 Uer
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: N-glycan synthesis EC Number: 2.4.1.130 Confidence Level: 0 AUTHORS: NOTES:
name: dolichyl-phosphate-mannose-glycolipid alpha-mannosyltransferase (uterus)
reversible: false
type: Reaction
kinetic law: MODEL1310110042#
fast: false
is described by: ECO:0000000
product: MODEL1310110042#
reactant: MODEL1310110042#

metaR PI45P3K
notes: GENE_ASSOCIATION: (5291.1 and 5295.3) or (5293.1 and 8503.1) or (5296.1 and 5290.1) or (5293.1 and 5295.1) or (5293.1 and 5295.3) or (5291.1 and 5295.1) or (5296.1 and 5291.1) or (5295.2 and 5290.1) or (10870.1 and 5294.1) or (23533.1 and 5294.1) or (5295.2 and 5293.1) or (5290.1 and 5295.1) or (5290.1 and 8503.1) or (5290.1 and 5295.3) or (5291.1 and 8503.1) or (5293.1 and 5296.1) or (5295.2 and 5291.1) SUBSYSTEM: Inositol phosphate metabolism EC Number: 2.7.1.153 Confidence Level: 4 AUTHORS: PMID:12507995,PMID:15780590,PMID:2174051,PMID:7624799,PMID:7713498,PMID:8246984,PMID:9113989 NOTES:NCD
is version of: http://identifiers.org/ec-code/2.7.11.1
kinetic law: MODEL1310110042#
fast: false
reversible: false
type: Reaction
is described by: ECO:0000000
is: SBO:0000176
reactant: MODEL1310110042#
product: MODEL1310110042#
name: phosphatidylinositol 4,5-bisphosphate 3-kinase
modifier: MODEL1310110042#
is version of: http://identifiers.org/ec-code/2.7.1.153

http://identifiers.org/biomodels.db/MODEL1310110042#_38d80cb1_652b_4d9e_a3d0_e2d4a0b26dac
constant: false
is: SBO:0000252
type: Species
initial amount: NaN
is: Q5TDP6
boundary condition: true
name: LGSN
is encoded by: hsa:51557
has only substance units: false
initial concentration: NaN

metaR DOLPGT2 Uer
fast: false
type: Reaction
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/2.4.1.265
notes: GENE_ASSOCIATION: (79053.1) or (79053.3) or (79053.2) SUBSYSTEM: N-glycan synthesis EC Number: Confidence Level: 0 AUTHORS: NOTES:EC 2.4.1.- NCD
is: SBO:0000176
name: dolichyl-phosphate-glucose-glycolipid alpha-glucosyltransferase (uterus)
kinetic law: MODEL1310110042#
reactant: MODEL1310110042#
modifier: MODEL1310110042#
reversible: false
product: MODEL1310110042#

metaR 3SALAASPm
is: SBO:0000185
notes: GENE_ASSOCIATION: (10165.1) or (8604.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: PMID:14598172 NOTES:PMID:486467 MM
type: Reaction
reactant: MODEL1310110042#
product: MODEL1310110042#
is described by: ECO:0000304
modifier: MODEL1310110042#
reversible: true
fast: false
kinetic law: MODEL1310110042#
name: cysteinesulfinate-aspartate mitochondrial shuttle

metaR LNELDCt
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11788354,PMID:12864740 NOTES:NJ
type: Reaction
product: MODEL1310110042#
kinetic law: MODEL1310110042#
fast: false
name: fatty acid transport via diffusion
reactant: MODEL1310110042#
is described by: ECO:0000000
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110042#_a0ab13d9_ea2f_4084_9f14_b9a371452c9f
type: Species
initial amount: NaN
is: SBO:0000252
constant: false
name: SULT1A1
has only substance units: false
initial concentration: NaN
is encoded by: hsa:6817
boundary condition: true

metaR S6TASE10ly
reversible: true
reactant: MODEL1310110042#
type: Reaction
is: SBO:0000176
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.1.6.4 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/3.2.1.23
name: galactose-6-sulfate sulfatase, lysosomal
is version of: http://identifiers.org/ec-code/3.4.16.5
modifier: MODEL1310110042#
kinetic law: MODEL1310110042#
is version of: http://identifiers.org/ec-code/3.2.1.18
is version of: http://identifiers.org/ec-code/3.1.6.4
fast: false
product: MODEL1310110042#

metaR EX pe hs LPAREN e RPAREN
kinetic law: MODEL1310110042#
reactant: MODEL1310110042#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for phosphatidylethanolamine
type: Reaction

metaR r1445
reactant: MODEL1310110042#
is: SBO:0000176
name: EC:1.3.3.6
fast: false
product: MODEL1310110042#
reversible: false
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 0 AUTHORS: PMID:17603022,PMID:6240978,PMID:7876265 NOTES:
kinetic law: MODEL1310110042#
is described by: ECO:0000000

metaR C180CPT1
notes: GENE_ASSOCIATION: (1375.4) or (1375.2) or (126129.1) or (1375.1) or (1374.1) or (1375.3) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.21 Confidence Level: 4 AUTHORS: PMID:1988962 NOTES:TV (see C160CRN)
type: Reaction
fast: false
is described by: ECO:0000269
reversible: false
is: SBO:0000176
reactant: MODEL1310110042#
name: production of stearoylcarnitine
product: MODEL1310110042#
modifier: MODEL1310110042#
kinetic law: MODEL1310110042#
is version of: http://identifiers.org/ec-code/2.3.1.21

metaM itaccoa m
name: itaconyl-CoA(5-)
boundary condition: false
type: Species
is: CHEBI:57381
initial amount: NaN
constant: false
has only substance units: false
notes: FORMULA: C26H35N7O19P3S CHARGE: -5 INCHI: InChI=1S/C26H40N7O19P3S/c1-13(25(39)40)8-16(35)56-7-6-28-15(34)4-5-29-23(38)20(37)26(2,3)10-49-55(46,47)52-54(44,45)48-9-14-19(51-53(41,42)43)18(36)24(50-14)33-12-32-17-21(27)30-11-31-22(17)33/h11-12,14,18-20,24,36-37H,1,4-10H2,2-3H3,(H,28,34)(H,29,38)(H,39,40)(H,44,45)(H,46,47)(H2,27,30,31)(H2,41,42,43)/p-5/t14-,18-,19-,20+,24-/m1/s1 EHMN_ABBREVIATION: C00531
is: HMDB03377
initial concentration: 1.0
is: SBO:0000247

metaR M16N6Tg
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/2.4.1.155
notes: GENE_ASSOCIATION: (4249.1) SUBSYSTEM: N-glycan synthesis EC Number: 2.4.1.155 Confidence Level: 0 AUTHORS: NOTES:NCD
is: SBO:0000176
reversible: false
kinetic law: MODEL1310110042#
reactant: MODEL1310110042#
modifier: MODEL1310110042#
product: MODEL1310110042#
type: Reaction
fast: false
name: alpha-1,6-mannosyl-glycoprotein 6-beta-N-acetylglucosaminyltransferase

metaM 3pg c
name: 3-Phospho-D-glycerate
is: C00197
is: SBO:0000247
boundary condition: false
is: http://identifiers.org/pubchem.compound/3497
initial concentration: 1.0
has only substance units: false
is: HMDB00807
initial amount: NaN
constant: false
is: CHEBI:58272
type: Species

http://identifiers.org/biomodels.db/MODEL1310110042#_c4a70301_6282_4541_a413_2e4978cfc67f
is encoded by: hsa:230
initial amount: NaN
boundary condition: true
name: ALDOC
type: Species
is: SBO:0000252
is: P09972
has only substance units: false
initial concentration: NaN
constant: false

metaM vacccrn c
initial amount: NaN
initial concentration: 1.0
has only substance units: false
constant: false
boundary condition: false
is: HMDB06351
is: SBO:0000247
name: Vaccenyl carnitine
notes: FORMULA: C25H47NO4 CHARGE: 0 INCHI: InChI=1/C25H47NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-25(29)30-23(26(2,3)4)21-22-24(27)28/h10-11,23H,5-9,12-22H2,1-4H3/b11-10+/t23-/m0/s1
type: Species

http://identifiers.org/biomodels.db/MODEL1310110042#_957635be_dd30_4133_bfd2_862eb70601cb
is: Q16831
initial concentration: NaN
boundary condition: true
constant: false
is encoded by: hsa:7378
name: UPP1
has only substance units: false
initial amount: NaN
type: Species
is: SBO:0000252

metaR SBCOAACOTx
kinetic law: MODEL1310110042#
product: MODEL1310110042#
reactant: MODEL1310110042#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: thioesterification of suberyl coa for release into cytosol
type: Reaction

metaR FAOXC150m
kinetic law: MODEL1310110042#
product: MODEL1310110042#
reversible: false
is version of: http://identifiers.org/ec-code/1.3.99.3
type: Reaction
fast: false
modifier: MODEL1310110042#
notes: GENE_ASSOCIATION: (35.1) or (34.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.99.3 Confidence Level: 4 AUTHORS: PMID:2565344 NOTES:by extension from even chain lumped FAO - should double-check stoich in future NJ
reactant: MODEL1310110042#
is described by: ECO:0000269
name: Beta oxidation of long chain fatty acid (odd chain)
is version of: http://identifiers.org/ec-code/1.3.8.1
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110042#_81ab106c_e3fd_4560_9a63_1469f1e75d51
is encoded by: hsa:1723
boundary condition: true
is: Q02127
initial amount: NaN
has only substance units: false
type: Species
is: SBO:0000252
name: DHODH
initial concentration: NaN
constant: false

http://identifiers.org/biomodels.db/MODEL1310110042#_fd8df62e_acb5_4d6c_9e1f_6ba803a2f7a1
has only substance units: false
initial amount: NaN
type: Species
initial concentration: NaN
is: SBO:0000297
is encoded by: hsa:4830
constant: false
boundary condition: true
name: NME1:NME2

metaR METLEUex
modifier: MODEL1310110042#
kinetic law: MODEL1310110042#
product: MODEL1310110042#
is: SBO:0000185
reactant: MODEL1310110042#
type: Reaction
notes: GENE_ASSOCIATION: (6520.1 and 8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14770310 NOTES:SAB see PMID 14770310
is described by: ECO:0000269
reversible: false
fast: false
name: Methionine/Leucine exchange (Met in)

metaM HC02202 c
initial concentration: 1.0
has only substance units: false
is: CHEBI:57398
constant: false
type: Species
notes: FORMULA: C20H31O4 CHARGE: -1 INCHI: InChI=1S/C20H32O4/c1-2-3-6-9-17(21)14-12-16-13-15-19(22)18(16)10-7-4-5-8-11-20(23)24/h12-18,21H,2-11H2,1H3,(H,23,24)/p-1/b14-12+/t16-,17-,18+/m0/s1 EHMN_ABBREVIATION: C04685
is: SBO:0000247
boundary condition: false
name: prostaglandin A1(1-)
initial amount: NaN

metaR r1444
product: MODEL1310110042#
is described by: ECO:0000000
reversible: false
name: EC:1.3.3.6
is: SBO:0000176
kinetic law: MODEL1310110042#
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 0 AUTHORS: PMID:17603022,PMID:6240978,PMID:7876265 NOTES:
reactant: MODEL1310110042#
type: Reaction
fast: false

metaR RE1233C
is version of: http://identifiers.org/ec-code/2.6.1.64
type: Reaction
fast: false
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (883.1) SUBSYSTEM: Tryptophan metabolism EC Number: 2.6.1.7 Confidence Level: 0 AUTHORS: PMID:10756023 NOTES:IT - removed H[c] on right hand side
kinetic law: MODEL1310110042#
product: MODEL1310110042#
name: RE1233
reversible: true
modifier: MODEL1310110042#
reactant: MODEL1310110042#
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110042#_f6e8781b_8047_49d2_9660_fe061329c079
type: Species
is: SBO:0000252
constant: false
name: _AI934540_1_c
has only substance units: false
boundary condition: true
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:AI934540

metaR DM dsT antigen g
kinetic law: MODEL1310110042#
reactant: MODEL1310110042#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 0 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: false
name: DM dsT antigen(g)
type: Reaction

metaM hexe3coa m
is: HMDB06522
constant: false
has only substance units: false
initial amount: NaN
boundary condition: false
initial concentration: 1.0
notes: FORMULA: C27H40N7O17P3S CHARGE: -4
type: Species
is: SBO:0000247
name: 3-hexenoylcoa

metaM atp e
type: Species
boundary condition: false
constant: false
initial amount: NaN
name: ATP(4-)
is: C00002
is: CHEBI:57299
is: SBO:0000247
is: HMDB00538
initial concentration: 1.0
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110042#_d394bd55_25b0_437f_b54b_ee4d20f3e6b2
initial concentration: NaN
type: Species
is: SBO:0000252
is encoded by: hsa:284098
has only substance units: false
name: PIGW
initial amount: NaN
constant: false
boundary condition: true
is: Q7Z7B1

metaR r1792
fast: false
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
type: Reaction
kinetic law: MODEL1310110042#
product: MODEL1310110042#
name: Y+LAT2 Utilized transport
reversible: false
is: SBO:0000185
modifier: MODEL1310110042#
reactant: MODEL1310110042#

http://identifiers.org/biomodels.db/MODEL1310110042#_54eefb0c_bdc2_4d60_92e4_399cec3ebf00
has only substance units: false
is: Q9UIG8
name: SLCO3A1
is: SBO:0000252
constant: false
initial concentration: NaN
type: Species
initial amount: NaN
is encoded by: hsa:28232
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110042#_bbbd3148_89f6_420a_923b_84de9b044523
boundary condition: true
has only substance units: false
is encoded by: hsa:10050
is: Q9Y2C5
constant: false
type: Species
is: SBO:0000252
initial amount: NaN
name: SLC17A4
initial concentration: NaN

metaM ksii core4 pre8 g
is: C00130
boundary condition: false
is: SBO:0000247
is: CHEBI:58053
is: HMDB00175
constant: false
initial amount: NaN
notes: FORMULA: C83H134N7O61SX CHARGE: -2
has only substance units: false
name: keratan sulfate II biosynthesis, precursor 8
type: Species
initial concentration: 1.0

metaR CYTK10n
product: MODEL1310110042#
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
kinetic law: MODEL1310110042#
reversible: true
type: Reaction
modifier: MODEL1310110042#
reactant: MODEL1310110042#
fast: false
name: cytidylate kinase (CMP,dGTP),nuclear
is version of: http://identifiers.org/ec-code/2.7.4.14
is described by: ECO:0000269
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110042#_3ae2840b_fa1e_44fe_9b8e_bc887cf9d1dc
name: NDUFS8
is: SBO:0000252
constant: false
boundary condition: true
is: O00217
initial amount: NaN
is encoded by: hsa:4728
type: Species
initial concentration: NaN
has only substance units: false

metaR 7DHCHSTEROLtr
kinetic law: MODEL1310110042#
type: Reaction
is: SBO:0000185
name: cholesterol precursor intracellular transport
fast: false
reactant: MODEL1310110042#
product: MODEL1310110042#
is described by: ECO:0000000
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: NOTES:specific mechanism not known, proton dependence for trans-mit transport has been suggested, however directionality and stoichiometry has not yet been elucidated. see PMID: 12770731 and others NJ

metaM c8dc x
initial amount: NaN
constant: false
boundary condition: false
has only substance units: false
type: Species
is: SBO:0000247
is: HMDB00893
name: suberyl carnitine
notes: FORMULA: C15H26NO6 CHARGE: -1
initial concentration: 1.0

metaM HC01410 m
initial amount: NaN
name: (2E)-Hexenoyl-CoA
initial concentration: 1.0
type: Species
is: CHEBI:28706
is: SBO:0000247
has only substance units: false
constant: false
boundary condition: false
notes: FORMULA: C27H40N7O17P3S CHARGE: -4 INCHI: InChI=1S/C27H44N7O17P3S/c1-4-5-6-7-18(36)55-11-10-29-17(35)8-9-30-25(39)22(38)27(2,3)13-48-54(45,46)51-53(43,44)47-12-16-21(50-52(40,41)42)20(37)26(49-16)34-15-33-19-23(28)31-14-32-24(19)34/h6-7,14-16,20-22,26,37-38H,4-5,8-13H2,1-3H3,(H,29,35)(H,30,39)(H,43,44)(H,45,46)(H2,28,31,32)(H2,40,41,42)/b7-6+/t16-,20-,21-,22+,26-/m1/s1 EHMN_ABBREVIATION: C05271

metaR C181OHc
kinetic law: MODEL1310110042#
product: MODEL1310110042#
reactant: MODEL1310110042#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: production of 3-hydroxyoctadecenoylcarnitinec
type: Reaction

metaR COQ5m
name: Ubiquinone biosynthesis methyltransferase COQ5
kinetic law: MODEL1310110042#
fast: false
reversible: false
is: SBO:0000176
product: MODEL1310110042#
type: Reaction
is described by: ECO:0000000
reactant: MODEL1310110042#
notes: GENE_ASSOCIATION: SUBSYSTEM: Ubiquinone synthesis EC Number: Confidence Level: 2 AUTHORS: PMID:10777520,PMID:1965190,PMID:7380842 NOTES:_2.1.1.- IT

http://identifiers.org/biomodels.db/MODEL1310110042#_28d722d8_d245_4b4f_a53f_be08e9697575
constant: false
boundary condition: true
name: MTMR3
type: Species
is encoded by: hsa:8897
initial amount: NaN
initial concentration: NaN
has only substance units: false
is: SBO:0000252

metaM bildglcur c
type: Species
initial amount: NaN
is: HMDB03325
constant: false
has only substance units: false
name: bis(beta-glucosyluronate)bilirubin
is: CHEBI:58471
is: SBO:0000247
boundary condition: false
initial concentration: 1.0
notes: FORMULA: C45H50N4O18 CHARGE: -2 INCHI: InChI=1S/C45H52N4O18/c1-7-20-19(6)40(58)49-27(20)14-25-18(5)23(10-12-31(51)65-45-37(57)33(53)35(55)39(67-45)43(62)63)29(47-25)15-28-22(17(4)24(46-28)13-26-16(3)21(8-2)41(59)48-26)9-11-30(50)64-44-36(56)32(52)34(54)38(66-44)42(60)61/h7-8,13-14,32-39,44-47,52-57H,1-2,9-12,15H2,3-6H3,(H,48,59)(H,49,58)(H,60,61)(H,62,63)/p-2/b26-13+,27-14+/t32-,33-,34-,35-,36+,37+,38-,39-,44+,45+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01616 EHMN_ABBREVIATION: C05787

metaR r1443
is described by: ECO:0000000
reactant: MODEL1310110042#
product: MODEL1310110042#
fast: false
is: SBO:0000176
reversible: false
kinetic law: MODEL1310110042#
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 0 AUTHORS: PMID:17603022,PMID:6240978,PMID:7876265 NOTES:
type: Reaction
name: EC:1.3.3.6

metaR STCOAtx
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: NOTES:interaction between peroxisomes and ER (some enzymes on the outer membrane) NJ
is: SBO:0000185
reversible: true
kinetic law: MODEL1310110042#
product: MODEL1310110042#
is described by: ECO:0000000
fast: false
reactant: MODEL1310110042#
name: fatty acid intracellular transport

metaM arg L c
initial amount: NaN
boundary condition: false
type: Species
is: SBO:0000247
notes: FORMULA: C6H15N4O2 CHARGE: 1 INCHI: InChI=1S/C6H14N4O2/c7-4(5(11)12)2-1-3-10-6(8)9/h4H,1-3,7H2,(H,11,12)(H4,8,9,10)/p+1/t4-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00065
is: HMDB00517
has only substance units: false
is: CHEBI:32682
constant: false
initial concentration: 1.0
name: L-argininium(1+)

metaR P4502C94
fast: false
is described by: ECO:0000269
modifier: MODEL1310110042#
name: cytochrome P450 2C9
reversible: false
is version of: http://identifiers.org/ec-code/1.14.13.48
is: SBO:0000176
kinetic law: MODEL1310110042#
reactant: MODEL1310110042#
product: MODEL1310110042#
type: Reaction
notes: GENE_ASSOCIATION: (1559.1) or (1557.1) SUBSYSTEM: Limonene and pinene degradation EC Number: 1.14.14.1 Confidence Level: 4 AUTHORS: PMID:11950794,PMID:11996015 NOTES:assumed to take place on outer membrane NJ

metaR NADPHtxu
kinetic law: MODEL1310110042#
name: NADPH transporter, peroxisome
reactant: MODEL1310110042#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 1 AUTHORS: PMID:10521434 NOTES:diffusion - unidirectional to avoid NADP/NAD loops w/ free hydrogens NJ
is: SBO:0000185
type: Reaction
fast: false
is described by: ECO:0000000
reversible: false
product: MODEL1310110042#

http://identifiers.org/biomodels.db/MODEL1310110042#_f18e4321_c2f4_4b8f_bb31_af175df7680e
type: Species
has only substance units: false
name: PDE7A
boundary condition: true
initial amount: NaN
is: Q13946
is: SBO:0000252
is encoded by: hsa:5150
constant: false
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110042#_a9474231_73c1_4999_be1c_0fee59da4472
constant: false
name: PDE9A
is: SBO:0000252
initial concentration: NaN
type: Species
is encoded by: hsa:5152
boundary condition: true
has only substance units: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110042#_11abd327_2fe9_4960_b975_c1843e614df9
boundary condition: true
initial concentration: NaN
initial amount: NaN
is: SBO:0000252
name: ADSL
is encoded by: hsa:158
constant: false
type: Species
has only substance units: false

metaR 4NPHSFte
reactant: MODEL1310110042#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:9344226 NOTES:unknown mechanism, related cyp P450 metabolism reactions NJ. Biochemical, Rat
fast: false
kinetic law: MODEL1310110042#
reversible: true
type: Reaction
product: MODEL1310110042#
is: SBO:0000185
is described by: ECO:0000000
name: xenobiotic transport

http://identifiers.org/biomodels.db/MODEL1310110042#_67f11bc8_e940_422b_8993_2177d09c6b42
name: PIGP:PIGA:PIGC:PIGH:DPM2:PIGQ
initial concentration: NaN
constant: false
boundary condition: true
is: SBO:0000297
is encoded by: hsa:5277
has part: P37287
is encoded by: hsa:8818
type: Species
has only substance units: false
initial amount: NaN

metaR SPHS1Ptr
product: MODEL1310110042#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: PMID:15052333,PMID:15585321 NOTES:unknown mechanism, however sphs1p is known to have intracellular and extracellular activity and signal transduction functions (PMID: 10751414 or PMID: 15585321). NJ
type: Reaction
fast: false
kinetic law: MODEL1310110042#
reactant: MODEL1310110042#
name: sphingosine-1-phosphate transport
is: SBO:0000185
reversible: true

metaR IPDPtx
is: SBO:0000185
fast: false
reversible: true
name: Isopentenyl diphosphate transport (peroxisome)
reactant: MODEL1310110042#
kinetic law: MODEL1310110042#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: 5.3.3.2 Confidence Level: 1 AUTHORS: PMID:11111079 NOTES:
product: MODEL1310110042#
type: Reaction
is described by: ECO:0000134

metaM atp c
boundary condition: false
name: ATP(4-)
type: Species
constant: false
initial concentration: 1.0
is: SBO:0000247
initial amount: NaN
is: CHEBI:30616
has only substance units: false
is: HMDB00538
is: C00002

metaR EX CLPND LPAREN e RPAREN
kinetic law: MODEL1310110042#
reactant: MODEL1310110042#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: clupanodonic acid (docosapentaenoic (n-3)) exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110042#_e03df014_521e_4c9c_9d6e_ce53df785bd9
has only substance units: false
boundary condition: true
constant: false
initial concentration: NaN
initial amount: NaN
name: DCXR
is encoded by: hsa:51181
is: Q7Z4W1
is: SBO:0000252
type: Species

http://identifiers.org/biomodels.db/MODEL1310110042#_0aff69a9_c34a_4769_99d3_88a0a9f93df8
type: Species
is encoded by: hsa:AA278423
has only substance units: false
initial amount: NaN
boundary condition: true
initial concentration: NaN
is: SBO:0000252
constant: false
name: _AA278423_1_c

metaM odecrn m
has only substance units: false
initial concentration: 1.0
notes: FORMULA: C25H47NO4 CHARGE: 0 INCHI: InChI=1/C25H47NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-25(29)30-23(21-24(27)28)22-26(2,3)4/h12-13,23H,5-11,14-22H2,1-4H3/t23-/m0/s1
is: HMDB01114
is: C00412
constant: false
initial amount: NaN
type: Species
is: CHEBI:57394
boundary condition: false
name: octadecenoyl carnitine
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110042#_c1841adb_d16e_4f7d_96da_7eb25a9fbf2d
initial amount: NaN
constant: false
is: SBO:0000252
initial concentration: NaN
has only substance units: false
is: P05062
is encoded by: hsa:229
name: ALDOB
type: Species
boundary condition: true

metaM taxol e
notes: FORMULA: C47H31NO14 CHARGE: 0 INCHI: InChI=1S/C47H51NO14/c1-25-31(60-43(56)36(52)35(28-16-10-7-11-17-28)48-41(54)29-18-12-8-13-19-29)23-47(57)40(61-42(55)30-20-14-9-15-21-30)38-45(6,32(51)22-33-46(38,24-58-33)62-27(3)50)39(53)37(59-26(2)49)34(25)44(47,4)5/h7-21,31-33,35-38,40,51-52,57H,22-24H2,1-6H3,(H,48,54)/t31-,32-,33+,35-,36+,37+,38-,40-,45+,46-,47+/m0/s1
is: SBO:0000247
boundary condition: false
constant: false
initial amount: NaN
initial concentration: 1.0
has only substance units: false
name: paclitaxel
type: Species
is: CHEBI:45863
is: C07394

http://identifiers.org/biomodels.db/MODEL1310110042#_33b0741b_a960_4e50_a33e_bcb0023f50aa
name: SLC34A1
boundary condition: true
constant: false
is encoded by: hsa:6569
has only substance units: false
type: Species
initial amount: NaN
initial concentration: NaN
is: SBO:0000252
is: Q7Z725

metaR ADA
notes: GENE_ASSOCIATION: (100.1) SUBSYSTEM: Purine catabolism EC Number: 3.5.4.4 Confidence Level: 4 AUTHORS: PMID:12381379,PMID:15016824 NOTES:Added EC- JLR
fast: false
is: SBO:0000176
name: Adenosine deaminase
is version of: http://identifiers.org/ec-code/3.5.4.4
modifier: MODEL1310110042#
reversible: false
is described by: ECO:0000269
reactant: MODEL1310110042#
product: MODEL1310110042#
kinetic law: MODEL1310110042#
type: Reaction

metaM octdececrn c
is: HMDB06351
type: Species
initial amount: NaN
is: SBO:0000247
notes: FORMULA: C25H47NO4 CHARGE: 0
initial concentration: 1.0
name: octadecenoyl carnitine (hypothetical, position of double bond unknown)
boundary condition: false
has only substance units: false
constant: false

http://identifiers.org/biomodels.db/MODEL1310110042#_4cb863e9_62b9_48ef_a489_7834e2f4b5ff
is encoded by: hsa:U37519
has only substance units: false
constant: false
name: _U37519_1_c
boundary condition: true
initial concentration: NaN
is: SBO:0000252
initial amount: NaN
type: Species

metaR LEUKTRB4t
reversible: true
reactant: MODEL1310110042#
kinetic law: MODEL1310110042#
type: Reaction
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:
is: SBO:0000185
fast: false
name: leukotriene B4 transport
product: MODEL1310110042#

metaR RE3001M
is described by: ECO:0000000
fast: false
modifier: MODEL1310110042#
name: RE3001
product: MODEL1310110042#
type: Reaction
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.3.1.34
notes: GENE_ASSOCIATION: (1666.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.1.34 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:7775433 NOTES:
kinetic law: MODEL1310110042#
reversible: true
reactant: MODEL1310110042#

metaR r1449
is: SBO:0000176
reversible: false
reactant: MODEL1310110042#
kinetic law: MODEL1310110042#
name: EC:1.3.3.6
type: Reaction
fast: false
product: MODEL1310110042#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.3.6 Confidence Level: 0 AUTHORS: PMID:17603022,PMID:1774065,PMID:3597357,PMID:6240978,PMID:7876265 NOTES:

metaM s7p c
has only substance units: false
is: SBO:0000247
notes: FORMULA: C7H13O10P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC01436 EHMN_ABBREVIATION: C05382
initial amount: NaN
is: C05382
boundary condition: false
is: HMDB01068
initial concentration: 1.0
type: Species
is: CHEBI:57483
constant: false
name: Sedoheptulose 7-phosphate

metaM xtsn c
is: SBO:0000247
name: xanthosine
has only substance units: false
notes: FORMULA: C10H12N4O6 CHARGE: 0 INCHI: InChI=1S/C10H12N4O6/c15-1-3-5(16)6(17)9(20-3)14-2-11-4-7(14)12-10(19)13-8(4)18/h2-3,5-6,9,15-17H,1H2,(H2,12,13,18,19)/t3-,5-,6-,9-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00838 EHMN_ABBREVIATION: C01762
is: CHEBI:18107
is: HMDB00299
initial amount: NaN
type: Species
initial concentration: 1.0
constant: false
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110042#_04158f52_91f6_4483_a57b_841a132b37bb
boundary condition: true
initial concentration: NaN
initial amount: NaN
constant: false
has only substance units: false
is: Q3MHC9
is: SBO:0000252
type: Species
name: SKIV2L2
is encoded by: hsa:23517

http://identifiers.org/biomodels.db/MODEL1310110042#_ca56b1f0_71f1_42d6_bd8a_55cf68509aa9
has part: P24539
is encoded by: hsa:522
has only substance units: false
name: ATP5H:ATP5L:NSF:ATP5F1:ATP5G3:ATP5I:ATP5J:ATP5J2
has part: P18859
boundary condition: true
type: Species
is: SBO:0000297
initial amount: NaN
is encoded by: hsa:515
has part: O75947
is encoded by: hsa:518
constant: false
is encoded by: hsa:10476
initial concentration: NaN

metaM ditp c
is: CHEBI:61382
notes: FORMULA: C10H11N4O13P3 CHARGE: -4 INCHI: InChI=1S/C10H15N4O13P3/c15-5-1-7(14-4-13-8-9(14)11-3-12-10(8)16)25-6(5)2-24-29(20,21)27-30(22,23)26-28(17,18)19/h3-7,15H,1-2H2,(H,20,21)(H,22,23)(H,11,12,16)(H2,17,18,19)/p-4/t5-,6+,7+/m0/s1 EHMN_ABBREVIATION: C01345
boundary condition: false
initial concentration: 1.0
is: HMDB03537
is: SBO:0000247
has only substance units: false
type: Species
name: dITP(4-)
initial amount: NaN
constant: false

metaR SERCYSNaEx
product: MODEL1310110042#
fast: false
name: L-serine/L-cysteine Na-dependent exchange (Ser-L in)
is described by: ECO:0000269
is: SBO:0000185
kinetic law: MODEL1310110042#
type: Reaction
reversible: false
notes: GENE_ASSOCIATION: (6509.1) or (6510.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14530974 NOTES:SAB see Kanai and Hediger 2004 (2003), PMID 14530974
modifier: MODEL1310110042#
reactant: MODEL1310110042#

metaM decdp m
initial amount: NaN
initial concentration: 1.0
has only substance units: false
notes: FORMULA: C50H81O7P2 CHARGE: -3 INCHI: InChI=1/C50H90O7P2/c1-41(2)21-31-53-58(51,54-32-22-42(3)4)57-59(52,35-25-45(9)10,36-26-46(11)12,37-27-47(13)14,38-28-48(15)16,39-29-49(17)18,40-30-50(19)20,55-33-23-43(5)6)56-34-24-44(7)8/h21-30H,31-40H2,1-20H3
type: Species
name: all trans Decaprenyl diphosphate
is: HMDB06288
boundary condition: false
constant: false
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110042#_24730a2b_e715_47f6_a3c8_65a34642265c
is encoded by: hsa:10841
initial amount: NaN
is: O95954
type: Species
initial concentration: NaN
constant: false
name: FTCD
has only substance units: false
is: SBO:0000252
boundary condition: true

metaR CYOOm3
reversible: false
type: Reaction
is: SBO:0000185
is described by: ECO:0000134
fast: false
reactant: MODEL1310110042#
notes: GENE_ASSOCIATION: (1351.1) and (1347.1) and (1329.1) and (1327.1) and (341947.1) and (9167.1) and (1350.1) and (4512.1) and (1349.1) and (1339.1) and (1345.1) and (4513.1) and (9377.1) and (125965.1) and (4514.1) and (170712.1) and (1346.1) and (1340.1) and (84701.1) and (1337.1) SUBSYSTEM: Oxidative phosphorylation EC Number: Confidence Level: 4 AUTHORS: PMID:10869362,PMID:12241082 NOTES:TV, 2% O2 lost in O2-
name: cytochrome c oxidase, mitochondrial Complex IV
kinetic law: MODEL1310110042#
is version of: http://identifiers.org/ec-code/1.9.3.1
modifier: MODEL1310110042#
product: MODEL1310110042#

http://identifiers.org/biomodels.db/MODEL1310110042#_e6f752ff_7511_47d7_b57c_fd1e59f72069
name: INPP5J
type: Species
is: SBO:0000252
constant: false
is encoded by: hsa:27124
boundary condition: true
initial amount: NaN
initial concentration: NaN
has only substance units: false

metaR CO2ter
is: SBO:0000185
reversible: true
type: Reaction
is described by: ECO:0000000
reactant: MODEL1310110042#
fast: false
product: MODEL1310110042#
name: CO2 endoplasmic reticular transport via diffusion
kinetic law: MODEL1310110042#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD

http://identifiers.org/biomodels.db/MODEL1310110042#_26ecee38_2250_47d2_b176_0f3514b4002d
type: Species
has only substance units: false
is encoded by: hsa:3295
name: HSD17B4
is: SBO:0000252
boundary condition: true
initial amount: NaN
initial concentration: NaN
constant: false
is: E9PB82

http://identifiers.org/biomodels.db/MODEL1310110042#_27ceaae3_c87d_4f4c_be6b_33143318a19f
name: PCBD2
has only substance units: false
boundary condition: true
type: Species
initial amount: NaN
is: Q9H0N5
is: SBO:0000252
initial concentration: NaN
is encoded by: hsa:84105
constant: false

metaM taxol c
is: CHEBI:45863
is: C07394
boundary condition: false
is: SBO:0000247
constant: false
initial concentration: 1.0
initial amount: NaN
has only substance units: false
name: paclitaxel
type: Species
notes: FORMULA: C47H31NO14 CHARGE: 0 INCHI: InChI=1S/C47H51NO14/c1-25-31(60-43(56)36(52)35(28-16-10-7-11-17-28)48-41(54)29-18-12-8-13-19-29)23-47(57)40(61-42(55)30-20-14-9-15-21-30)38-45(6,32(51)22-33-46(38,24-58-33)62-27(3)50)39(53)37(59-26(2)49)34(25)44(47,4)5/h7-21,31-33,35-38,40,51-52,57H,22-24H2,1-6H3,(H,48,54)/t31-,32-,33+,35-,36+,37+,38-,40-,45+,46-,47+/m0/s1

metaR AIRCr
reactant: MODEL1310110042#
reversible: true
product: MODEL1310110042#
kinetic law: MODEL1310110042#
notes: GENE_ASSOCIATION: (10606.1) SUBSYSTEM: Purine synthesis EC Number: Confidence Level: 4 AUTHORS: NOTES:
is: SBO:0000176
name: phosphoribosylaminoimidazole carboxylase
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/6.3.2.6
fast: false
modifier: MODEL1310110042#
type: Reaction

metaR DAGt
product: MODEL1310110042#
kinetic law: MODEL1310110042#
is described by: ECO:0000269
reversible: true
name: diacylglycerol transport
reactant: MODEL1310110042#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: 2.7.1.107 Confidence Level: 2 AUTHORS: NOTES:
fast: false
is: SBO:0000185
type: Reaction

metaM pcrn x
name: propionyl-carnitine
is: HMDB00824
is: SBO:0000247
boundary condition: false
initial concentration: 1.0
is: http://identifiers.org/pubchem.compound/107738
constant: false
initial amount: NaN
has only substance units: false
notes: FORMULA: C10H19NO4 CHARGE: 0 INCHI: InChI=1/C10H19NO4/c1-5-10(14)15-8(6-9(12)13)7-11(2,3)4/h8H,5-7H2,1-4H3
type: Species

http://identifiers.org/biomodels.db/MODEL1310110042#_d3e7f564_c5bd_495b_8654_29b010dbba6d
is: Q548A7
is: SBO:0000252
constant: false
is encoded by: hsa:65010
name: SLC26A6
initial concentration: NaN
initial amount: NaN
type: Species
boundary condition: true
has only substance units: false

metaR GluForTx
reversible: false
kinetic law: MODEL1310110042#
notes: GENE_ASSOCIATION: (10841.1) or (10841.2) SUBSYSTEM: Histidine metabolism EC Number: 2.1.2.5 Confidence Level: 4 AUTHORS: PMID:12815595 NOTES:SAB
is version of: http://identifiers.org/ec-code/2.1.2.5
reactant: MODEL1310110042#
product: MODEL1310110042#
type: Reaction
fast: false
is: SBO:0000176
modifier: MODEL1310110042#
is described by: ECO:0000269
name: Glutamate formimidoyltransferase

http://identifiers.org/biomodels.db/MODEL1310110042#_dd4c6d66_d4f5_412a_a399_8503a40e7a63
boundary condition: true
constant: false
initial amount: NaN
is: SBO:0000252
type: Species
initial concentration: NaN
name: _BG035985_1_c
is encoded by: hsa:BG035985
has only substance units: false

metaR CBR2
fast: false
type: Reaction
name: Carbonyl reductase [NADPH] 1
reactant: MODEL1310110042#
is version of: http://identifiers.org/ec-code/1.1.1.189
kinetic law: MODEL1310110042#
product: MODEL1310110042#
is: SBO:0000176
is described by: ECO:0000269
reversible: false
notes: GENE_ASSOCIATION: (873.1) SUBSYSTEM: Eicosanoid metabolism EC Number: 1.1.1.197 Confidence Level: 4 AUTHORS: PMID:8740524,PMID:9740676 NOTES:multiple EC EC 1.1.1.189 EC 1.1.1.197 NJ
modifier: MODEL1310110042#

metaR ADAe
notes: GENE_ASSOCIATION: (100.1) SUBSYSTEM: Purine catabolism EC Number: 3.5.4.4 Confidence Level: 4 AUTHORS: PMID:12381379,PMID:15016824 NOTES:adenosine deaminase has been found on cell surface in human (Gonzales-Gronow et al, JBC, 2004,279,20993-20998). IT
kinetic law: MODEL1310110042#
is described by: ECO:0000269
name: Adenosine deaminase, extracellular
fast: false
is version of: http://identifiers.org/ec-code/3.5.4.4
type: Reaction
product: MODEL1310110042#
is: SBO:0000176
modifier: MODEL1310110042#
reactant: MODEL1310110042#
reversible: false

metaR LTD4DP
type: Reaction
is: SBO:0000176
name: Leukotriene D4 dipeptidase
is described by: ECO:0000000
product: MODEL1310110042#
reactant: MODEL1310110042#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Eicosanoid metabolism EC Number: 2.3.2.2 Confidence Level: 4 AUTHORS: PMID:11160764,PMID:3001504 NOTES:Converts leukotriene D4 (LTD4) to leukotriene E4 (LTE4). unknown compartmentalization, cytosolic by default NJ
reversible: true
kinetic law: MODEL1310110042#

metaR DHPM1
fast: false
notes: GENE_ASSOCIATION: (1807.1) or (1809.1) or (1808.1) SUBSYSTEM: Pyrimidine catabolism EC Number: 3.5.2.2 Confidence Level: 4 AUTHORS: PMID:8973361 NOTES:
modifier: MODEL1310110042#
reactant: MODEL1310110042#
kinetic law: MODEL1310110042#
name: dihydropyrimidinase (5,6-dihydrouracil)
is described by: ECO:0000269
type: Reaction
is version of: http://identifiers.org/ec-code/3.5.2.2
reversible: false
product: MODEL1310110042#
is: SBO:0000176

metaR C162ACBP
kinetic law: MODEL1310110042#
product: MODEL1310110042#
reactant: MODEL1310110042#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: transport of 3-hydroxy trans7,10-hexadecadienoylcoa from mitochondria into cytosol
type: Reaction

metaR GGH 7DHFe
is version of: http://identifiers.org/ec-code/3.4.19.9
type: Reaction
fast: false
is described by: ECO:0000000
modifier: MODEL1310110042#
reactant: MODEL1310110042#
kinetic law: MODEL1310110042#
is: SBO:0000176
reversible: false
name: Gamma-glutamyl hydrolase (7DHF), extracellular
notes: GENE_ASSOCIATION: (8836.1) SUBSYSTEM: Folate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:11375437,PMID:2867095,PMID:9614206 NOTES:REMOVES EITHER ONE OR TWO GLUTAMYL RESIDUES WITH A REACTION (WILL ONLY REPRESENT 1) IT
product: MODEL1310110042#

http://identifiers.org/biomodels.db/MODEL1310110042#_66b08222_3772_4095_9d01_43f67e132ddd
boundary condition: true
is encoded by: hsa:226
has only substance units: false
initial amount: NaN
initial concentration: NaN
type: Species
constant: false
name: ALDOA
is: SBO:0000252

metaM m2emgacpail hs r
constant: false
name: (dimannosyl),(phosphoethanolaminyl)-mannosyl-glucosylaminyl-acylphosphatidylinositol (H6)
is: C00080
boundary condition: false
has only substance units: false
initial amount: NaN
is: http://identifiers.org/pubchem.compound/3380
is: CHEBI:24636
type: Species
initial concentration: 1.0
notes: FORMULA: C51H94N2O32P2FULLRCO2FULLR2CO2 CHARGE: 0
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110042#_162894f7_ff9c_41ea_9084_4dec992bb7ea
initial amount: NaN
boundary condition: true
initial concentration: NaN
type: Species
is: SBO:0000252
has only substance units: false
is: O15270
constant: false
is encoded by: hsa:9517
name: SPTLC2

http://identifiers.org/biomodels.db/MODEL1310110042#_f40b2c46_9490_4c16_a58f_43c437451b93
is: P49189
name: ALDH9A1
constant: false
type: Species
initial amount: NaN
has only substance units: false
initial concentration: NaN
boundary condition: true
is encoded by: hsa:223
is: SBO:0000252

metaR IVCOAACBP
kinetic law: MODEL1310110042#
product: MODEL1310110042#
reactant: MODEL1310110042#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of Isovaleryl-CoA from mitochondria into cytosol
type: Reaction

metaR CMPACNAtn
name: CMP-Sia nuclear export
reversible: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: NOTES:NCD
product: MODEL1310110042#
reactant: MODEL1310110042#
type: Reaction
is: SBO:0000185
kinetic law: MODEL1310110042#
is described by: ECO:0000000
fast: false

metaM cmpacna n
is: SBO:0000247
has only substance units: false
type: Species
notes: FORMULA: C20H29N4O16P CHARGE: -2 INCHI: InChI=1S/C20H31N4O16P/c1-7(26)22-12-8(27)4-20(18(32)33,39-16(12)13(29)9(28)5-25)40-41(35,36)37-6-10-14(30)15(31)17(38-10)24-3-2-11(21)23-19(24)34/h2-3,8-10,12-17,25,27-31H,4-6H2,1H3,(H,22,26)(H,32,33)(H,35,36)(H2,21,23,34)/p-2/t8-,9+,10+,12+,13+,14+,15+,16+,17+,20+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00126 EHMN_ABBREVIATION: C00128
initial amount: NaN
initial concentration: 1.0
constant: false
is: CHEBI:57812
name: CMP-N-acetyl-beta-neuraminate(2-)
boundary condition: false
is: HMDB01176

metaR r1799
product: MODEL1310110042#
fast: false
reversible: false
kinetic law: MODEL1310110042#
name: Y+LAT2 Utilized transport
type: Reaction
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is: SBO:0000185
reactant: MODEL1310110042#
modifier: MODEL1310110042#
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110042#_3cf41aea_5e29_4a66_91e4_65fe89a97154
initial concentration: NaN
type: Species
is encoded by: hsa:9488
is: Q92521
constant: false
initial amount: NaN
has only substance units: false
name: PIGB
boundary condition: true
is: SBO:0000252

metaM pail4p hs c
is: CHEBI:58178
has only substance units: false
initial amount: NaN
constant: false
name: 1-phosphatidyl-1D-myo-inositol 4-phosphate(3-)
is: SBO:0000247
type: Species
notes: FORMULA: C9H15O12P2FULLRCO2FULLR2CO2 CHARGE: -3 EHMN_ABBREVIATION: C01277
initial concentration: 1.0
boundary condition: false

metaR FAOXC2452256x
kinetic law: MODEL1310110042#
name: Beta oxidation of long chain fatty acid
is version of: http://identifiers.org/ec-code/4.2.1.107
is version of: http://identifiers.org/ec-code/1.3.3.6
reactant: MODEL1310110042#
fast: false
modifier: MODEL1310110042#
reversible: false
is version of: http://identifiers.org/ec-code/1.1.1.35
product: MODEL1310110042#
is: SBO:0000176
is described by: ECO:0000000
type: Reaction
is version of: http://identifiers.org/ec-code/2.3.1.16
notes: GENE_ASSOCIATION: (3295.1 and 30.1 and 51.2) or (51.1 and 3295.1 and 30.1) or (30.1 and 51.2 and 1962.1) or (51.1 and 30.1 and 1962.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.74 Confidence Level: 4 AUTHORS: NOTES:peroxisomal (very long chain FA) - - in peroxisome, no fad, 1ste set of beta-ox is by acyl-coa oxidase (passes electrons directly to o2 -> h2o2) c24:5,n-6 -> c22:5, n-6 4 step FAO lumped also includes EC 1.1.1.35, 1.1.1.211, 1.3.3.6, 4.2.1.17, 4.2.1.74 NJ

metaR THRGLYexR
is described by: ECO:0000304
type: Reaction
notes: GENE_ASSOCIATION: (56301.1) and (6520.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10734121,PMID:10863037,PMID:14770310 NOTES:
modifier: MODEL1310110042#
is: SBO:0000185
name: L-threonine/glycine reversible exchange
fast: false
reactant: MODEL1310110042#
product: MODEL1310110042#
reversible: true
kinetic law: MODEL1310110042#

http://identifiers.org/biomodels.db/MODEL1310110042#_e51dadd1_3634_499c_ae9d_c795f668b00d
type: Species
initial concentration: NaN
is: SBO:0000252
boundary condition: true
name: GLUD1
is: E9KL48
is encoded by: hsa:2746
has only substance units: false
initial amount: NaN
constant: false

metaR ASNTHRNaEx
type: Reaction
reactant: MODEL1310110042#
product: MODEL1310110042#
is: SBO:0000185
reversible: false
name: L-threonine/L-asparagine Na-dependent exchange (Asn-L in)
modifier: MODEL1310110042#
is described by: ECO:0000269
kinetic law: MODEL1310110042#
notes: GENE_ASSOCIATION: (6510.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14530974 NOTES:SAB see Kanai and Hediger 2004 (2003), PMID 14530974
fast: false

http://identifiers.org/biomodels.db/MODEL1310110042#_0cd28001_d953_4e0f_b783_04925acbfeb1
initial concentration: NaN
initial amount: NaN
type: Species
constant: false
is encoded by: hsa:3029
has only substance units: false
name: HAGH
is: SBO:0000252
is: Q16775
boundary condition: true

metaM malttr e
notes: FORMULA: C18H32O16 CHARGE: 0 INCHI: InChI=1S/C18H32O16/c19-1-4-7(22)8(23)12(27)17(31-4)34-15-6(3-21)32-18(13(28)10(15)25)33-14-5(2-20)30-16(29)11(26)9(14)24/h4-29H,1-3H2/t4-,5-,6-,7-,8+,9-,10-,11-,12-,13-,14-,15-,16+,17-,18-/m1/s1 EHMN_ABBREVIATION: C01835
is: CHEBI:27931
name: maltotriose
initial amount: NaN
type: Species
is: HMDB01262
constant: false
is: SBO:0000247
boundary condition: false
initial concentration: 1.0
is: C01835
has only substance units: false

metaR METS
name: methionine synthase
product: MODEL1310110042#
is described by: ECO:0000134
type: Reaction
is: SBO:0000176
notes: GENE_ASSOCIATION: (4548.1) SUBSYSTEM: Methionine and cysteine metabolism EC Number: 2.1.1.13 Confidence Level: 4 AUTHORS: PMID:8968736,PMID:9013615 NOTES:Human Y/N: Y
is version of: http://identifiers.org/ec-code/2.1.1.13
modifier: MODEL1310110042#
kinetic law: MODEL1310110042#
reversible: false
reactant: MODEL1310110042#
fast: false

metaM lald L c
type: Species
name: (S)-lactaldehyde
notes: FORMULA: C3H6O2 CHARGE: 0 INCHI: InChI=1S/C3H6O2/c1-3(5)2-4/h2-3,5H,1H3/t3-/m0/s1
initial concentration: 1.0
is: SBO:0000247
initial amount: NaN
is: HMDB03052
boundary condition: false
has only substance units: false
is: CHEBI:18041
constant: false

metaM ksi pre3 g
is: HMDB00175
notes: FORMULA: C93H152N6O67X CHARGE: -1
initial amount: NaN
is: CHEBI:58053
is: SBO:0000247
boundary condition: false
initial concentration: 1.0
is: C00130
name: keratan sulfate I biosynthesis, precursor 3
has only substance units: false
type: Species
constant: false

metaR NACHEX18ly
notes: GENE_ASSOCIATION: (3073.1) or (3073.1 and 3074.1) or (3074.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.52 Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12706724,PMID:8993162 NOTES:NCD
is version of: http://identifiers.org/ec-code/3.2.1.52
kinetic law: MODEL1310110042#
fast: false
type: Reaction
reactant: MODEL1310110042#
product: MODEL1310110042#
modifier: MODEL1310110042#
is: SBO:0000176
reversible: false
is described by: ECO:0000000
name: beta-N-acetylhexosaminidase, lysosomal

metaM fadh2 m
type: Species
is: SBO:0000247
initial amount: NaN
has only substance units: false
notes: FORMULA: C27H33N9O15P2 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00770 EHMN_ABBREVIATION: C01352
is: CHEBI:58307
is: HMDB01197
boundary condition: false
is: C01352
initial concentration: 1.0
constant: false
name: Flavin adenine dinucleotide reduced

metaM glyald m
constant: false
has only substance units: false
initial concentration: 1.0
is: CHEBI:17378
boundary condition: false
type: Species
is: HMDB01051
is: SBO:0000247
notes: FORMULA: C3H6O3 CHARGE: 0 INCHI: InChI=1S/C3H6O3/c4-1-3(6)2-5/h1,3,5-6H,2H2/t3-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00436 EHMN_ABBREVIATION: C00577
initial amount: NaN
name: D-glyceraldehyde

metaR r0186
is version of: http://identifiers.org/ec-code/1.2.1.5
reactant: MODEL1310110042#
modifier: MODEL1310110042#
name: Ethanolamine-phosphate phospho-lyase (deaminating) EC:4.2.3.2
type: Reaction
product: MODEL1310110042#
fast: false
reversible: false
is: SBO:0000176
kinetic law: MODEL1310110042#
notes: GENE_ASSOCIATION: (220.1) or (218.1) or (221.1) or (222.1) or (U37519.1) SUBSYSTEM: Glycerophospholipid metabolism EC Number: 4.2.3.2 Confidence Level: 0 AUTHORS: PMID:5498429 NOTES:
is described by: ECO:0000000

metaM atp n
has only substance units: false
initial concentration: 1.0
is: HMDB00538
name: ATP(3-)
notes: FORMULA: C10H12N5O13P3 CHARGE: -4 INCHI: InChI=1S/C10H16N5O13P3/c11-8-5-9(13-2-12-8)15(3-14-5)10-7(17)6(16)4(26-10)1-25-30(21,22)28-31(23,24)27-29(18,19)20/h2-4,6-7,10,16-17H,1H2,(H,21,22)(H,23,24)(H2,11,12,13)(H2,18,19,20)/p-3/t4-,6-,7-,10-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00012 EHMN_ABBREVIATION: C00002
initial amount: NaN
is: CHEBI:57299
boundary condition: false
type: Species
is: SBO:0000247
constant: false

metaR LEULEUPEPT1tc
kinetic law: MODEL1310110042#
product: MODEL1310110042#
reactant: MODEL1310110042#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of Leucylleucine by the apical PEPT1 amino acid transporters across the brush border cells of the enterocytes of the intestine and renal cells
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110042#_f89424e4_f1bd_453b_83a7_fb8362fa2801
is encoded by: hsa:10020
initial amount: NaN
has only substance units: false
is: B7Z428
initial concentration: NaN
boundary condition: true
constant: false
type: Species
is: SBO:0000252
name: GNE

metaR C60CPT1
kinetic law: MODEL1310110042#
product: MODEL1310110042#
reactant: MODEL1310110042#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: production of hexanoylcarnitine
type: Reaction

metaR FAOXC164C165m
kinetic law: MODEL1310110042#
product: MODEL1310110042#
reactant: MODEL1310110042#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C16:4-->C16:5)m
type: Reaction

metaM ksi deg21 l
is: HMDB00143
constant: false
is: SBO:0000247
name: keratan sulfate I, degradation product 21
notes: FORMULA: C132H213N9O114S6 CHARGE: -6
initial amount: NaN
boundary condition: false
has only substance units: false
is: CHEBI:12936
type: Species
initial concentration: 1.0

metaM octdececrn m
is: SBO:0000247
notes: FORMULA: C25H47NO4 CHARGE: 0
has only substance units: false
is: HMDB06351
initial concentration: 1.0
name: octadecenoyl carnitine (hypothetical, position of double bond unknown)
boundary condition: false
type: Species
constant: false
initial amount: NaN

metaR FAOXC16BRx
kinetic law: MODEL1310110042#
product: MODEL1310110042#
reactant: MODEL1310110042#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid activation(C16br)x
type: Reaction

metaR TETPENT3COAtx
is described by: ECO:0000000
product: MODEL1310110042#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 0 AUTHORS: NOTES:interaction between peroxisomes and ER (some enzymes on the outer membrane) NJ
reactant: MODEL1310110042#
reversible: true
name: fatty acid intracellular transport
is: SBO:0000185
kinetic law: MODEL1310110042#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110042#_ee0c750e_3457_45ad_9a23_fc2456cc677e
constant: false
initial amount: NaN
is: SBO:0000252
type: Species
is: Q16842
initial concentration: NaN
boundary condition: true
has only substance units: false
name: ST3GAL2
is encoded by: hsa:6483

http://identifiers.org/biomodels.db/MODEL1310110042#_5ffea739_9a7d_4a0c_8f36_2757720885a0
is encoded by: hsa:U37519
type: Species
initial amount: NaN
initial concentration: NaN
boundary condition: true
constant: false
is: SBO:0000252
has only substance units: false
name: _U37519_1_m

metaR r2003
is described by: ECO:0000000
type: Reaction
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.15
fast: false
reactant: MODEL1310110042#
is: SBO:0000185
reversible: false
modifier: MODEL1310110042#
product: MODEL1310110042#
kinetic law: MODEL1310110042#

metaR DGCHOLte
reversible: true
name: bile acid intracellular transport
reactant: MODEL1310110042#
kinetic law: MODEL1310110042#
is described by: ECO:0000000
is: SBO:0000185
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 1 AUTHORS: NOTES:unknown mechanism, however bile acids need to be secreted out of the cell NJ
product: MODEL1310110042#
fast: false

metaM atp m
has only substance units: false
is: HMDB00538
initial concentration: 1.0
name: ATP(4-)
type: Species
is: C00002
is: SBO:0000247
boundary condition: false
initial amount: NaN
constant: false
is: CHEBI:57299

metaR FAOXC12DCTc
kinetic law: MODEL1310110042#
product: MODEL1310110042#
reactant: MODEL1310110042#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: transport of dodecanedioyl carnitine into cytosol
type: Reaction

metaR GCC2cm
reactant: MODEL1310110042#
is version of: http://identifiers.org/ec-code/1.4.4.2
name: glycine-cleavage complex (lipoamide), mitochondrial
modifier: MODEL1310110042#
reversible: true
is version of: http://identifiers.org/ec-code/2.1.2.10
is: SBO:0000176
product: MODEL1310110042#
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (275.1) and (1738.1) and (2731.1) and (2653.1) SUBSYSTEM: Glycine, serine, alanine and threonine metabolism EC Number: 2.1.2.10 Confidence Level: 4 AUTHORS: PMID:15355973 NOTES:NCD
fast: false
kinetic law: MODEL1310110042#
type: Reaction
is version of: http://identifiers.org/ec-code/1.8.1.4

metaR r1078
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:10049700,PMID:10574970,PMID:11389679,PMID:11557028,PMID:11564694,PMID:12824232,PMID:12930836,PMID:14574404,PMID:16288981,PMID:911815 NOTES:
is described by: ECO:0000000
product: MODEL1310110042#
fast: false
name: Vesicular transport
kinetic law: MODEL1310110042#
reversible: false
type: Reaction
is: SBO:0000185
reactant: MODEL1310110042#

metaR FAOXC123C102x
kinetic law: MODEL1310110042#
product: MODEL1310110042#
reactant: MODEL1310110042#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C12:3-->C10:2)x
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110042#_a33c0b04_39d8_4f3f_89c9_34e073cee2ed
constant: false
initial concentration: NaN
is: SBO:0000252
is: Q11201
name: ST3GAL1
is encoded by: hsa:6482
boundary condition: true
initial amount: NaN
type: Species
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110042#_6e9f94c9_0043_411e_88fd_02f8a9d120ae
constant: false
has only substance units: false
is encoded by: hsa:11136
is: SBO:0000252
initial concentration: NaN
name: SLC7A9
type: Species
boundary condition: true
is: P82251
initial amount: NaN

metaR P4502C93
kinetic law: MODEL1310110042#
product: MODEL1310110042#
is described by: ECO:0000269
is: SBO:0000176
type: Reaction
is version of: http://identifiers.org/ec-code/1.14.13.48
reactant: MODEL1310110042#
notes: GENE_ASSOCIATION: (1559.1) or (1557.1) SUBSYSTEM: Limonene and pinene degradation EC Number: 1.14.14.1 Confidence Level: 4 AUTHORS: PMID:11950794,PMID:11996015 NOTES:assumed to take place on outer membrane NJ
modifier: MODEL1310110042#
name: cytochrome P450 2C9
reversible: false
fast: false

metaR PYAM5POr
name: pyridoxamine 5'-phosphate oxidase
is described by: ECO:0000269
reactant: MODEL1310110042#
fast: false
notes: GENE_ASSOCIATION: (55163.1) SUBSYSTEM: Vitamin B6 metabolism EC Number: 1.4.3.5 Confidence Level: 4 AUTHORS: PMID:6380540 NOTES:NCD IT
is: SBO:0000176
product: MODEL1310110042#
modifier: MODEL1310110042#
kinetic law: MODEL1310110042#
reversible: true
is version of: http://identifiers.org/ec-code/1.4.3.5
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110042#_c2c0dd1b_8d90_4e8c_b0f6_fae99cbff4a1
initial amount: NaN
constant: false
is: E9PAY8
boundary condition: true
is: SBO:0000252
name: PPAP2C
is encoded by: hsa:8612
type: Species
has only substance units: false
initial concentration: NaN

metaM tyr L m
is: CHEBI:17895
notes: FORMULA: C9H11NO3 CHARGE: 0 INCHI: InChI=1S/C9H11NO3/c10-8(9(12)13)5-6-1-3-7(11)4-2-6/h1-4,8,11H,5,10H2,(H,12,13)/t8-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00085
is: SBO:0000247
has only substance units: false
initial concentration: 1.0
is: HMDB00158
constant: false
boundary condition: false
initial amount: NaN
type: Species
name: L-tyrosine

metaM CE5236 n
is: CHEBI:28002
is: HMDB03952
initial concentration: 1.0
initial amount: NaN
has only substance units: false
boundary condition: false
constant: false
is: SBO:0000247
type: Species
name: O2'-4a-cyclic-tetrahydrobiopterin
notes: FORMULA: C9H13N5O3 CHARGE: 0 INCHI: InChI=1/C9H13N5O3/c1-3-5(15)4-2-11-6-9(14-4,17-3)7(16)13-8(10)12-6/h3-5,14-15H,2H2,1H3,(H3,10,11,12,13,16)/p+1/t3-,4u,5+,9u/m0/s1 EHMN_ABBREVIATION: CE5236

metaM vacccrn m
constant: false
boundary condition: false
has only substance units: false
name: Vaccenyl carnitine
initial concentration: 1.0
is: HMDB06351
type: Species
notes: FORMULA: C25H47NO4 CHARGE: 0 INCHI: InChI=1/C25H47NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-25(29)30-23(26(2,3)4)21-22-24(27)28/h10-11,23H,5-9,12-22H2,1-4H3/b11-10+/t23-/m0/s1
initial amount: NaN
is: SBO:0000247

metaM HC02202 e
has only substance units: false
boundary condition: false
is: CHEBI:57398
initial amount: NaN
type: Species
constant: false
name: prostaglandin A1(1-)
initial concentration: 1.0
is: SBO:0000247
notes: FORMULA: C20H31O4 CHARGE: -1 INCHI: InChI=1S/C20H32O4/c1-2-3-6-9-17(21)14-12-16-13-15-19(22)18(16)10-7-4-5-8-11-20(23)24/h12-18,21H,2-11H2,1H3,(H,23,24)/p-1/b14-12+/t16-,17-,18+/m0/s1 EHMN_ABBREVIATION: C04685

metaM arg L e
is: HMDB00517
notes: FORMULA: C6H15N4O2 CHARGE: 1 INCHI: InChI=1S/C6H14N4O2/c7-4(5(11)12)2-1-3-10-6(8)9/h4H,1-3,7H2,(H,11,12)(H4,8,9,10)/p+1/t4-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00065
boundary condition: false
type: Species
initial amount: NaN
is: CHEBI:32682
has only substance units: false
initial concentration: 1.0
is: SBO:0000247
name: L-argininium(1+)
constant: false

metaR FACOAL80i
reactant: MODEL1310110042#
notes: GENE_ASSOCIATION: (2181.1) or (2181.2) SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.2 Confidence Level: 4 AUTHORS: NOTES:JLR Also 6.2.1.3
is described by: ECO:0000269
type: Reaction
is version of: http://identifiers.org/ec-code/6.2.1.3
reversible: false
is: SBO:0000176
kinetic law: MODEL1310110042#
modifier: MODEL1310110042#
name: fatty-acid--CoA ligase (octanoate)
fast: false
product: MODEL1310110042#

metaR HDDACBP
kinetic law: MODEL1310110042#
product: MODEL1310110042#
reactant: MODEL1310110042#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: transport of (S)-3-Hydroxydodecanoyl-CoA from mitochondria into the cytosol
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110042#_801451a2_5f2d_4515_b62c_59c3c1b05735
constant: false
name: _LOC374569_1_e
initial amount: NaN
initial concentration: NaN
boundary condition: true
type: Species
is: SBO:0000252
is encoded by: hsa:LOC374569
has only substance units: false

metaR CITt4 2
fast: false
reversible: true
product: MODEL1310110042#
reactant: MODEL1310110042#
type: Reaction
kinetic law: MODEL1310110042#
is described by: ECO:0000269
name: citrate transport via sodium symport
modifier: MODEL1310110042#
notes: GENE_ASSOCIATION: (9058.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:8946005,PMID:8967342 NOTES:NCD
is: SBO:0000185

metaM fadh2 r
constant: false
boundary condition: false
name: FADH2(2-)
type: Species
is: HMDB01197
is: SBO:0000247
has only substance units: false
notes: FORMULA: C27H33N9O15P2 CHARGE: -2 INCHI: InChI=1S/C27H35N9O15P2/c1-10-3-12-13(4-11(10)2)35(24-18(32-12)25(42)34-27(43)33-24)5-14(37)19(39)15(38)6-48-52(44,45)51-53(46,47)49-7-16-20(40)21(41)26(50-16)36-9-31-17-22(28)29-8-30-23(17)36/h3-4,8-9,14-16,19-21,26,32,37-41H,5-7H2,1-2H3,(H,44,45)(H,46,47)(H2,28,29,30)(H2,33,34,42,43)/p-2/t14-,15+,16+,19-,20+,21+,26+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00770 EHMN_ABBREVIATION: C01352
initial concentration: 1.0
initial amount: NaN
is: CHEBI:58307

metaR CYSSERNaEx
is described by: ECO:0000269
kinetic law: MODEL1310110042#
product: MODEL1310110042#
is: SBO:0000185
reactant: MODEL1310110042#
type: Reaction
fast: false
notes: GENE_ASSOCIATION: (6509.1) or (6510.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14530974 NOTES:SAB see Kanai and Hediger 2004 (2003), PMID 14530974
modifier: MODEL1310110042#
name: L-serine/L-cysteine Na-dependent exchange (Cys-L in)
reversible: false

metaR EX gam LPAREN e RPAREN
kinetic law: MODEL1310110042#
reactant: MODEL1310110042#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for D-Glucosamine
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110042#_931ed2b1_6e32_47a9_a2c1_cf8a6a8cbfb3
type: Species
has only substance units: false
boundary condition: true
initial amount: NaN
name: PKLR
constant: false
is: P30613
is encoded by: hsa:5313
is: SBO:0000252
initial concentration: NaN

metaR C204CPT2
kinetic law: MODEL1310110042#
is described by: ECO:0000000
fast: false
name: arachidonic acid transport into the mitochondria
modifier: MODEL1310110042#
is version of: http://identifiers.org/ec-code/2.3.1.21
reversible: false
reactant: MODEL1310110042#
notes: GENE_ASSOCIATION: (1376.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: PMID:1528846,PMID:1988962 NOTES:TDV C20:4 transport
type: Reaction
product: MODEL1310110042#
is: SBO:0000176

metaM bildglcur e
initial concentration: 1.0
is: HMDB03325
is: CHEBI:58471
type: Species
is: SBO:0000247
initial amount: NaN
has only substance units: false
constant: false
name: bis(beta-glucosyluronate)bilirubin
boundary condition: false
notes: FORMULA: C45H50N4O18 CHARGE: -2 INCHI: InChI=1S/C45H52N4O18/c1-7-20-19(6)40(58)49-27(20)14-25-18(5)23(10-12-31(51)65-45-37(57)33(53)35(55)39(67-45)43(62)63)29(47-25)15-28-22(17(4)24(46-28)13-26-16(3)21(8-2)41(59)48-26)9-11-30(50)64-44-36(56)32(52)34(54)38(66-44)42(60)61/h7-8,13-14,32-39,44-47,52-57H,1-2,9-12,15H2,3-6H3,(H,48,59)(H,49,58)(H,60,61)(H,62,63)/p-2/b26-13+,27-14+/t32-,33-,34-,35-,36+,37+,38-,39-,44+,45+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01616 EHMN_ABBREVIATION: C05787

http://identifiers.org/biomodels.db/MODEL1310110042#_26a3290d_75de_40f8_a309_932c8ce0ff0f
constant: false
initial concentration: NaN
boundary condition: true
has only substance units: false
is encoded by: hsa:790
name: CAD
initial amount: NaN
is: P27708
type: Species
is: SBO:0000252

metaM glx c
name: glyoxylate
is: SBO:0000247
is: CHEBI:36655
boundary condition: false
initial amount: NaN
has only substance units: false
notes: FORMULA: C2H1O3 CHARGE: -1 INCHI: InChI=1S/C2H2O3/c3-1-2(4)5/h1H,(H,4,5)/p-1 EHMN_ABBREVIATION: C00048
is: HMDB00119
constant: false
initial concentration: 1.0
type: Species

metaR METAT
kinetic law: MODEL1310110042#
product: MODEL1310110042#
name: methionine adenosyltransferase
modifier: MODEL1310110042#
is: SBO:0000176
reversible: false
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/2.5.1.6
reactant: MODEL1310110042#
type: Reaction
fast: false
notes: GENE_ASSOCIATION: (4143.1) or (27430.2 and 4144.1) or (27430.1 and 4144.1) SUBSYSTEM: Methionine and cysteine metabolism EC Number: Confidence Level: 4 AUTHORS: NOTES:

http://identifiers.org/biomodels.db/MODEL1310110042#_77f4af62_a2d4_41a7_9605_d2aee18ea42c
type: Species
boundary condition: true
name: PLCG2
is: P16885
initial concentration: NaN
is: SBO:0000252
has only substance units: false
initial amount: NaN
is encoded by: hsa:5336
constant: false

http://identifiers.org/biomodels.db/MODEL1310110042#_1b526bd7_4e59_463f_80e0_1c3e85efaa17
initial concentration: NaN
is encoded by: hsa:286016
constant: false
is: SBO:0000252
initial amount: NaN
boundary condition: true
has only substance units: false
name: TPI1P2
type: Species

metaR DCSPTN1CRNt
kinetic law: MODEL1310110042#
notes: GENE_ASSOCIATION: (788.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: NOTES:NJ
is: SBO:0000185
reactant: MODEL1310110042#
type: Reaction
fast: false
is described by: ECO:0000269
product: MODEL1310110042#
reversible: false
modifier: MODEL1310110042#
name: transport into the mitochondria (carnitine)

metaM ditp n
is: HMDB03537
is: SBO:0000247
is: CHEBI:61382
name: dITP(4-)
has only substance units: false
notes: FORMULA: C10H11N4O13P3 CHARGE: -4 INCHI: InChI=1S/C10H15N4O13P3/c15-5-1-7(14-4-13-8-9(14)11-3-12-10(8)16)25-6(5)2-24-29(20,21)27-30(22,23)26-28(17,18)19/h3-7,15H,1-2H2,(H,20,21)(H,22,23)(H,11,12,16)(H2,17,18,19)/p-4/t5-,6+,7+/m0/s1 EHMN_ABBREVIATION: C01345
boundary condition: false
initial amount: NaN
constant: false
type: Species
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110042#_aaddf3c0_f4c4_4a80_b315_351fec49850c
initial concentration: NaN
is: SBO:0000252
is: Q6ZWP6
type: Species
boundary condition: true
initial amount: NaN
has only substance units: false
name: ACAD8
constant: false
is encoded by: hsa:27034

metaR C4STMO2Pr
reversible: false
reactant: MODEL1310110042#
type: Reaction
product: MODEL1310110042#
is described by: ECO:0000000
is: SBO:0000176
notes: GENE_ASSOCIATION: (50814.1) SUBSYSTEM: Cholesterol metabolism EC Number: Confidence Level: 4 AUTHORS: NOTES:double check rxn specifics - see lit ref: Marijanovic, Molecular Endocrinology 2003 17:1715-1725 ER version NJ
kinetic law: MODEL1310110042#
name: C-4 methyl sterol oxidase
modifier: MODEL1310110042#
is version of: http://identifiers.org/ec-code/1.1.1.170
fast: false

http://identifiers.org/biomodels.db/MODEL1310110042#_3ba729fa_76a0_40bf_ba7b_1bfdb7c0f922
is: SBO:0000297
boundary condition: true
type: Species
has part: Q8WYR1
initial concentration: NaN
has only substance units: false
constant: false
initial amount: NaN
is encoded by: hsa:23533
name: PIK3R5:PIK3CG

metaR r0181
notes: GENE_ASSOCIATION: (AA081045.1) or (AI620219.1) or (220.1) or (219.1) or (217.1) or (218.1) or (224.1) or (221.1) or (222.1) or (501.1) or (223.1) or (AU149534.1) or (T83654.1) or (U37519.1) SUBSYSTEM: Purine catabolism EC Number: 3.6.1.5 Confidence Level: 0 AUTHORS: PMID:15652174,PMID:16752921,PMID:17095758 NOTES:
reversible: true
kinetic law: MODEL1310110042#
reactant: MODEL1310110042#
product: MODEL1310110042#
is version of: http://identifiers.org/ec-code/1.2.1.5
type: Reaction
fast: false
name: ITP diphosphohydrolase Purine metabolism EC:3.6.1.5
is: SBO:0000176
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/1.2.1.3
modifier: MODEL1310110042#

metaR ACNMLr
reversible: true
product: MODEL1310110042#
notes: GENE_ASSOCIATION: SUBSYSTEM: Aminosugar metabolism EC Number: 4.1.3.3 Confidence Level: 2 AUTHORS: NOTES:JLR
reactant: MODEL1310110042#
is described by: ECO:0000000
is: SBO:0000176
type: Reaction
kinetic law: MODEL1310110042#
name: N-Acetylneuraminate lyase (reversible)
fast: false

metaR r1681
reactant: MODEL1310110042#
reversible: false
modifier: MODEL1310110042#
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is described by: ECO:0000000
kinetic law: MODEL1310110042#
type: Reaction
fast: false
product: MODEL1310110042#
name: Y+LAT2 Utilized transport
is: SBO:0000185

metaR EX 4hphac LPAREN e RPAREN
kinetic law: MODEL1310110042#
reactant: MODEL1310110042#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 4-Hydroxyphenylacetate exchange
type: Reaction

metaR FAOXC181C161x
kinetic law: MODEL1310110042#
product: MODEL1310110042#
reactant: MODEL1310110042#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta xoidation(C18:1-->C16:1)x
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110042#_367ac9b1_f21d_4b1c_8ed4_fa7c4bf64b6c
initial amount: NaN
is: SBO:0000297
has only substance units: false
initial concentration: NaN
type: Species
constant: false
name: SUCLG1:SUCLA2
has part: E5KS60
is encoded by: hsa:8803
boundary condition: true

metaR r0706
kinetic law: MODEL1310110042#
is: SBO:0000176
reactant: MODEL1310110042#
product: MODEL1310110042#
notes: GENE_ASSOCIATION: (34.1) or (3712.1) or (R14373.1) SUBSYSTEM: Bile acid synthesis EC Number: 1.3.3.6 Confidence Level: 0 AUTHORS: PMID:11356170,PMID:8943006 NOTES:RE1814X
is version of: http://identifiers.org/ec-code/1.3.99.3
type: Reaction
fast: false
is described by: ECO:0000000
reversible: false
is version of: http://identifiers.org/ec-code/1.3.99.10
name: acyl-Coenzyme A dehydrogenase family, member 9 Bile acid biosynthesis EC:1.3.3.6
modifier: MODEL1310110042#

metaR MCCCrm
reactant: MODEL1310110042#
reversible: true
is described by: ECO:0000269
modifier: MODEL1310110042#
name: methylcrotonoyl-CoA carboxylase, mitochondrial
fast: false
kinetic law: MODEL1310110042#
is version of: http://identifiers.org/ec-code/6.4.1.4
notes: GENE_ASSOCIATION: (56922.1 and 64087.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 6.4.1.4 Confidence Level: 4 AUTHORS: PMID:11181649,PMID:11406611 NOTES:MM
product: MODEL1310110042#
is: SBO:0000176
type: Reaction

metaM hs deg16 l
initial concentration: 1.0
initial amount: NaN
is: HMDB02704
constant: false
notes: FORMULA: C49H72N2O54S4 CHARGE: -6
boundary condition: false
is: SBO:0000247
has only substance units: false
type: Species
is: CHEBI:21338
name: heparan sulfate, degradation product 16

http://identifiers.org/biomodels.db/MODEL1310110042#_706c391e_b7d1_4763_8301_909c328a13ad
initial amount: NaN
has only substance units: false
name: GALT
initial concentration: NaN
is: SBO:0000252
is: E7ET32
type: Species
is encoded by: hsa:2592
constant: false
boundary condition: true

metaR NRVNCCOAtx
reactant: MODEL1310110042#
product: MODEL1310110042#
is described by: ECO:0000000
is: SBO:0000185
reversible: true
type: Reaction
fast: false
name: fatty acid intracellular transport
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: NOTES:interaction between peroxisomes and ER (some enzymes on the outer membrane) NJ
kinetic law: MODEL1310110042#

metaR EX ahcys LPAREN e RPAREN
kinetic law: MODEL1310110042#
reactant: MODEL1310110042#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: Exchange of S-adenosyl-L-homocysteine
type: Reaction

metaR EX amp LPAREN e RPAREN
kinetic law: MODEL1310110042#
reactant: MODEL1310110042#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: AMP exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110042#_8a299c6f_8c49_4c58_86be_6aaa0f7e5d7c
is encoded by: hsa:4726
is: Q6IBC4
type: Species
initial amount: NaN
has only substance units: false
name: NDUFS6
initial concentration: NaN
is: SBO:0000252
constant: false
boundary condition: true

metaM 3pg m
is: SBO:0000247
is: CHEBI:58272
has only substance units: false
notes: FORMULA: C3H4O7P CHARGE: -3 INCHI: InChI=1S/C3H7O7P/c4-2(3(5)6)1-10-11(7,8)9/h2,4H,1H2,(H,5,6)(H2,7,8,9)/p-3/t2-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00186 EHMN_ABBREVIATION: C00197
boundary condition: false
initial amount: NaN
name: (2R)-2-hydroxy-3-(phosphonatooxy)propanoate
type: Species
constant: false
initial concentration: 1.0
is: HMDB00807

metaR G12MT1 L
notes: GENE_ASSOCIATION: SUBSYSTEM: N-glycan synthesis EC Number: 2.4.1.131 Confidence Level: 0 AUTHORS: NOTES:
is described by: ECO:0000000
kinetic law: MODEL1310110042#
reactant: MODEL1310110042#
fast: false
reversible: false
name: Glycolipid 1,2-alpha-D-mannosyltransferase (liver)
is: SBO:0000176
type: Reaction
product: MODEL1310110042#

metaM odecrn c
is: C00412
type: Species
is: HMDB01114
is: SBO:0000247
constant: false
initial concentration: 1.0
initial amount: NaN
has only substance units: false
boundary condition: false
notes: FORMULA: C25H47NO4 CHARGE: 0 INCHI: InChI=1/C25H47NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-25(29)30-23(21-24(27)28)22-26(2,3)4/h12-13,23H,5-11,14-22H2,1-4H3/t23-/m0/s1
is: CHEBI:57394
name: octadecenoyl carnitine

http://identifiers.org/biomodels.db/MODEL1310110042#_ff407f39_821d_478c_a31b_ff78a7d5c535
is: SBO:0000252
initial amount: NaN
has only substance units: false
boundary condition: true
name: FOLR1
constant: false
type: Species
is encoded by: hsa:2348
initial concentration: NaN

metaM CE2417 m
constant: false
notes: FORMULA: C35H54N7O18P3S CHARGE: -4 INCHI: InChI=1/C35H58N7O18P3S/c1-4-5-6-7-8-9-10-11-12-13-23(43)18-26(45)64-17-16-37-25(44)14-15-38-33(48)30(47)35(2,3)20-57-63(54,55)60-62(52,53)56-19-24-29(59-61(49,50)51)28(46)34(58-24)42-22-41-27-31(36)39-21-40-32(27)42/h8-9,11-12,21-24,28-30,34,43,46-47H,4-7,10,13-20H2,1-3H3,(H,37,44)(H,38,48)(H,52,53)(H,54,55)(H2,36,39,40)(H2,49,50,51)/p-4/b9-8-,12-11-/t23-,24-,28+,29+,30u,34-/m0/s1 EHMN_ABBREVIATION: CE2417
boundary condition: false
initial amount: NaN
initial concentration: 1.0
type: Species
name: 3(S)-hydroxy-5Z,8Z-tetradecadienoyl-CoA
has only substance units: false
is: SBO:0000247
is: HMDB11123
is: CHEBI:28387

metaR r0707
type: Reaction
is described by: ECO:0000000
kinetic law: MODEL1310110042#
reactant: MODEL1310110042#
product: MODEL1310110042#
reversible: true
name: 2-Amino-4-hydroxy-6-(erythro-1,2,3-trihydroxypropyl) dihydropteridine triphosphate phosphohydrolase (alkaline optimum) Folate biosynthesis EC:3.1.3.1
modifier: MODEL1310110042#
is: SBO:0000176
fast: false
is version of: http://identifiers.org/ec-code/2.3.1.168
notes: GENE_ASSOCIATION: (1629.1) SUBSYSTEM: Unassigned EC Number: 3.1.3.1 Confidence Level: 0 AUTHORS: PMID:1730777 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110042#_e7a6588f_d153_41e2_a720_b36903e7ec0d
constant: false
is: SBO:0000252
boundary condition: true
is: Q15181
is encoded by: hsa:5464
has only substance units: false
initial amount: NaN
name: PPA1
initial concentration: NaN
type: Species

metaR CMPACNAtg
modifier: MODEL1310110042#
fast: false
product: MODEL1310110042#
is: SBO:0000185
type: Reaction
name: CMP-Sia Golgi transport via CMP antiport
reversible: true
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (10559.1) SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 4 AUTHORS: PMID:12759756,PMID:9010752,PMID:9644260 NOTES:NCD
kinetic law: MODEL1310110042#
reactant: MODEL1310110042#

metaR GTHPm
is: SBO:0000176
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (10935.1) or (10935.2) or (2879.1) SUBSYSTEM: Glutathione metabolism EC Number: 1.11.1.9 Confidence Level: 4 AUTHORS: PMID:12427732 NOTES:TV (8-15-2003)
fast: false
name: glutathione peroxidase, mitochondria
is version of: http://identifiers.org/ec-code/1.11.1.15
is version of: http://identifiers.org/ec-code/1.11.1.12
kinetic law: MODEL1310110042#
modifier: MODEL1310110042#
reversible: true
type: Reaction
reactant: MODEL1310110042#
product: MODEL1310110042#

http://identifiers.org/biomodels.db/MODEL1310110042#_4ceaa79f_3a87_46a6_8974_6236330b9f59
has only substance units: false
boundary condition: true
initial concentration: NaN
constant: false
type: Species
initial amount: NaN
is encoded by: hsa:6487
is: SBO:0000252
name: ST3GAL3

metaR biomass reaction
fast: false
reactant: MODEL1310110042#
is: SBO:0000185
product: MODEL1310110042#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
kinetic law: MODEL1310110042#
reversible: false
is described by: ECO:0000134
type: Reaction
name: Generic human biomass reaction

metaR ACNAMPH
reversible: false
fast: false
is described by: ECO:0000000
is: SBO:0000176
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Aminosugar metabolism EC Number: 3.1.3.29 Confidence Level: 2 AUTHORS: NOTES:NCD
product: MODEL1310110042#
kinetic law: MODEL1310110042#
name: N-Acetylneuraminate 9-phosphate phosphohydrolase
reactant: MODEL1310110042#

http://identifiers.org/biomodels.db/MODEL1310110042#_50878c83_c02e_4f53_b0bf_8cee4602fa1f
is: P30825
boundary condition: true
type: Species
has only substance units: false
is encoded by: hsa:6541
constant: false
name: SLC7A1
is: SBO:0000252
initial concentration: NaN
initial amount: NaN

metaM accoa x
name: Acetyl-CoA
is: C00024
boundary condition: false
constant: false
is: SBO:0000247
is: CHEBI:57288
initial concentration: 1.0
is: HMDB01206
notes: FORMULA: C23H34N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00033 EHMN_ABBREVIATION: C00024
has only substance units: false
type: Species
initial amount: NaN

metaM asp L c
is: SBO:0000247
initial amount: NaN
is: CHEBI:29991
type: Species
constant: false
initial concentration: 1.0
boundary condition: false
has only substance units: false
is: HMDB00191
name: L-aspartate(1-)
notes: FORMULA: C4H6NO4 CHARGE: -1 INCHI: InChI=1S/C4H7NO4/c5-2(4(8)9)1-3(6)7/h2H,1,5H2,(H,6,7)(H,8,9)/p-1/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00055